title: [Alveolar proteinosis: a cause of immunodeficiency].
abstract: Alveolar proteinosis is a rare disease, characterized by accumulation of surfactant in alveoli. Various forms have been identified (congenital, secondary or auto-immune). Treatment is to be reserved for patients that experience moderate to severe symptoms. It requires whole lung lavages, in order to clear the alveoli from the proteinaceous material. Macrophages dysfunction plays a crucial role in the development of the disease and causes immunodeficiency, which in turn can promote opportunistic infections, in patients a priori thought to be immunocompetent.
authors.affiliation: Service de médecine interne générale, HUG, Genève. leila.bennhammoud@gmail.com
authors.forename: Leila
authors.initials: L
authors.lastname: Ben Hammoud
authors.affiliation: Département de médecine interne, Centre hospitalier du Valais romand, Sierre.
authors.forename: Cédric
authors.initials: C
authors.lastname: Dessimoz
authors.affiliation: Département d'anesthésiologiew et réanimation, Centre hospitalier du Valais romand, Sion.
authors.forename: Daniel
authors.initials: D
authors.lastname: Rudaz
authors.affiliation: Département d'anesthésiologiew et réanimation, Centre hospitalier du Valais romand, Sion.
authors.forename: Patrick
authors.initials: P
authors.lastname: Ravussin
authors.affiliation: Médecine générale FMH.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Oggier
authors.affiliation: Département d'anesthésiologiew et réanimation, Centre hospitalier du Valais romand, Sion.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Tschopp
mesh_terms: D018893:Bronchoalveolar Lavage / Q000379:methods*; D006801:Humans; D016867:Immunocompromised Host; D008264:Macrophages / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009894:Opportunistic Infections / Q000209:etiology; D011649:Pulmonary Alveolar Proteinosis / Q000150:complications / Q000276:immunology / Q000628:therapy*; D012720:Severity of Illness Index