title: Birth of cone bipolar cells, but not rod bipolar cells, is associated with existing RGCs.
abstract: Retinal ganglion cells (RGCs) play important roles in retinogenesis. They are required for normal retinal histogenesis and retinal cell number balance. Developmental RGC loss is typically characterized by initial retinal neuronal number imbalance and subsequent loss of retinal neurons. However, it is not clear whether loss of a specific non-RGC cell type in the RGC-depleted retina is due to reduced cell production or subsequent degeneration. Taking advantage of three knockout mice with varying degrees of RGC depletion, we re-examined bipolar cell production in these retinas from various aspects. Results show that generation of the cone bipolar cells is correlated with the existing number of RGCs. However, generation of the rod bipolar cells is unaffected by RGC shortage. Results report the first observation that RGCs selectively influence the genesis of subsequent retinal cell types.
authors.affiliation: Department of Ophthalmology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Bai
authors.affiliation: Department of Ophthalmology and Visual Science, University of Texas Health Science Center at Houston Medical School, Houston, Texas, United States of America.
authors.forename: Takae
authors.initials: T
authors.lastname: Kiyama
authors.affiliation: Department of Ophthalmology and Visual Science, University of Texas Health Science Center at Houston Medical School, Houston, Texas, United States of America.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Ophthalmology and Visual Science, University of Texas Health Science Center at Houston Medical School, Houston, Texas, United States of America.
authors.forename: Steven W
authors.initials: SW
authors.lastname: Wang
mesh_terms: D000367:Age Factors; D000818:Animals; D017209:Apoptosis / Q000235:genetics; D051792:Basic Helix-Loop-Helix Proteins / Q000172:deficiency; D002452:Cell Count; D049109:Cell Proliferation; D005136:Eye Proteins / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000172:deficiency; D012160:Retina / Q000196:embryology / Q000378:metabolism / Q000473:pathology; D051245:Retinal Bipolar Cells / Q000378:metabolism* / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000378:metabolism* / Q000473:pathology
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; C117638:Atoh7 protein, mouse; C491582:Vsx1 protein, mouse