title: Phenotypic heterogeneity of asian Indian inversion deletions gγ(aγδβ)0 breakpoint a and breakpoint B.
abstract: Asian Indian inversion deletion Gγ (Aγδβ)0-thalassemia is a rare entities characterized by high HbF. Due to interaction with various genetic factors, patients with Gγ (Aγδβ)0-thalassemia showed clinical variability. Here we are presenting the phenotypic expression of Gγ(Aγδβ)0 thalassemia under influence of various co-inherited factors. Patient with α-globin gene deletion had mild phenotype than the patient with β-globin mutations. Patient with alpha gene deletion were presenting clinical character like thalassemia intermedia while Gγ (Aγδβ)0-thalassemia patients with co- presence of beta thalssemia mutation clinically behaved like thalassemia major.
authors.affiliation: Department of Haematology, All India Institute of Medical Sciences, New Pvt. Ward (2nd Floor), Ansari Nagar, New Delhi, 110 029 India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Pandey
authors.affiliation: Department of Haematology, All India Institute of Medical Sciences, New Pvt. Ward (2nd Floor), Ansari Nagar, New Delhi, 110 029 India.
authors.forename: Sweta
authors.initials: S
authors.lastname: Pandey
authors.affiliation: Department of Haematology, All India Institute of Medical Sciences, New Pvt. Ward (2nd Floor), Ansari Nagar, New Delhi, 110 029 India.
authors.forename: Ravi
authors.initials: R
authors.lastname: Ranjan
authors.affiliation: Department of Environmental Biology, APS University Rewa, Rewa, India.
authors.forename: Rahasyamani
authors.initials: R
authors.lastname: Mishra
authors.affiliation: Department of Haematology, All India Institute of Medical Sciences, New Pvt. Ward (2nd Floor), Ansari Nagar, New Delhi, 110 029 India.
authors.forename: Monica
authors.initials: M
authors.lastname: Sharma
authors.affiliation: Department of Haematology, All India Institute of Medical Sciences, New Pvt. Ward (2nd Floor), Ansari Nagar, New Delhi, 110 029 India.
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena
keywords: Delta beta thalassemia; Gap-PCR; PCR; Thalassemia