title: Diffuse pulmonary neuroendocrine cell hyperplasia involving the chest wall.
abstract: Diffuse pulmonary neuroendocrine cell hyperplasia (DIPNECH) is characterized by a diffuse hypertrophy of neuroendocrine cells along the distal bronchioles. This condition is characterized by obstructive lung physiology and the development of small carcinoid tumors. We present a case of DIPNECH in a patient undergoing surgery for a primary lung adenocarcinoma. Interestingly, the chest wall also demonstrated involvement of DIPNECH indicated by the presence of small carcinoid tumors. The absence of any lung carcinoid tumor greater than 5 mm and the absence of lymph node metastases render the chest wall involvement unlikely to represent metastatic disease.
authors.affiliation: Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Adnan M
authors.initials: AM
authors.lastname: Al-Ayoubi
authors.affiliation: Division of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: Jonathan S
authors.initials: JS
authors.lastname: Ralston
authors.affiliation: Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina.
authors.forename: S Russ
authors.initials: SR
authors.lastname: Richardson
authors.affiliation: Division of Cardiothoracic Surgery, Medical University of South Carolina, Charleston, South Carolina. Electronic address: denlinge@musc.edu.
authors.forename: Chadrick E
authors.initials: CE
authors.lastname: Denlinger
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000601:surgery; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002276:Carcinoid Tumor / Q000175:diagnosis* / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia / Q000473:pathology / Q000601:surgery; D007150:Immunohistochemistry; D033162:Incidental Findings; D008175:Lung Neoplasms / Q000175:diagnosis / Q000601:surgery; D055099:Neuroendocrine Cells / Q000473:pathology*; D011013:Pneumonectomy / Q000379:methods; D018570:Risk Assessment; D020775:Thoracic Surgery, Video-Assisted / Q000379:methods; D035441:Thoracic Wall / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome
keywords: 5