title: Pharmacokinetics and pharmacodynamics of febuxostat under fasting conditions in healthy individuals.
abstract: The aim of the present study was to investigate the pharmacokinetic and pharmacodynamic characteristics of febuxostat following the administration of single and multiple oral doses under fasting conditions to healthy individuals. Thirty-six healthy subjects were randomly divided into three groups, each containing 12 subjects (six male and six female) as follows: Group A, treated with a single oral dose of febuxostat (40 mg); group B, treated with a single oral dose of febuxostat (80 mg) followed by multiple oral doses of febuxostat for 7 days; and group C, treated with a single oral dose of febuxostat (120 mg). Blood samples were collected, and the plasma drug levels and serum uric acid (UA) concentrations were determined by clinical laboratory testing. Febuxostat displayed a linear pharmacokinetic profile for oral doses of 40 to 120 mg. Drug accumulation was not detected following multiple oral doses. When febuxostat was administered as single doses of 40, 80 and 120 mg, the 24-h UA concentration (UA24) values displayed a linear correlation with the dosage. The relationship between UA24 and the three single dose levels (40, 80 and 120 mg) was analyzed. The difference in UA24 between every single dose was significant (P<0.05). After 3 and 7 days of dosing, reductions of 46.67 and 52.69%, respectively, were observed in UA24. On day 7 of dosing, the mean reduction in the UA concentration was 51.83±7.00%. This study demonstrates that febuxostat reduces serum UA concentrations in a dose-linear manner.
authors.affiliation: Department of Pharmacology, General Hospital of Beijing Military Command, Beijing 100700, P.R. China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.affiliation: Department of Pharmacology, General Hospital of Beijing Military Command, Beijing 100700, P.R. China.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: DI
authors.affiliation: Department of Pharmacology, General Hospital of Beijing Military Command, Beijing 100700, P.R. China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Pharmacology, General Hospital of Beijing Military Command, Beijing 100700, P.R. China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Pharmacology, General Hospital of Beijing Military Command, Beijing 100700, P.R. China.
authors.forename: Yongge
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Pharmacology, General Hospital of Beijing Military Command, Beijing 100700, P.R. China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Department of Pharmacology, General Hospital of Beijing Military Command, Beijing 100700, P.R. China.
authors.forename: Lixue
authors.initials: L
authors.lastname: Song
authors.affiliation: Department of Pharmacology, General Hospital of Beijing Military Command, Beijing 100700, P.R. China.
authors.forename: Xueting
authors.initials: X
authors.lastname: Xu
keywords: febuxostat; pharmacodynamics; pharmacokinetics; serum uric acid