title: [A case of surgical resection of a combined hepatocellular and cholangiocarcinoma after transarterial chemoembolization].
abstract: A 48-year-old woman was admitted to our hospital for the treatment of a liver tumor (diameter, 10 cm), which was detected by abdominal contrast-enhanced computed tomography. The tumor occupied mainly the left medial segment and caudate lobe, invaded the left and right hepatic arteries, and obstructed the left portal vein. The tumor was diagnosed as an unresectable intrahepatic cholangiocarcinoma, and chemotherapy (a combination of gemcitabine and S-1) was initiated. Because the tumor continued to grow despite the chemotherapy, we performed transarterial chemoembolization(TACE)as a second-line treatment, which successfully reduced tumor size to 7 cm. Thereafter, surgical resection was performed. Histopathological examination indicated the presence of intrahepatic cholangiocarcinoma, which formed the main component, combined with hepatocellular carcinoma. This tumor was diagnosed as a combined hepatocellular and cholangiocarcinoma. Although adjuvant chemotherapy was not administered because of prolonged pancytopenia, currently, at 5 years after the operation, the patient is alive and has not experienced any recurrence.
authors.affiliation: Dept. of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Yakoshi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Toyoki
authors.forename: Keinosuke
authors.initials: K
authors.lastname: Ishido
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kudo
authors.forename: Norihisa
authors.initials: N
authors.lastname: Kimura
authors.forename: Taiichi
authors.initials: T
authors.lastname: Wakiya
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
mesh_terms: D001650:Bile Duct Neoplasms / Q000601:surgery* / Q000628:therapy; D001653:Bile Ducts, Intrahepatic / Q000601:surgery*; D006528:Carcinoma, Hepatocellular / Q000601:surgery* / Q000628:therapy; D016461:Chemoembolization, Therapeutic; D018281:Cholangiocarcinoma / Q000601:surgery* / Q000628:therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery* / Q000628:therapy; D008875:Middle Aged; D016896:Treatment Outcome