title: Synthesis and determination of chronic and acute thermal and chemical pain activities of a new derivative of phencyclidine in rats.
abstract: Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with Ketamine and PCP. The results indicated a marked anti-nociception 2-25 min after ketamine injection, but the analgesic effect remained for 40 min following PCP-OCH3-tetralyl application in tail immersion test. However, the data obtained from formalin test showed that the chronic anti-nociception effect of ketamine was higher than PCP and PCP-OCH3-tetralyl exhibited almost similar analgesic effect.
authors.affiliation: epartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Ahmadi
authors.affiliation: Department of Physiology, School of Medicine, Shahed University, Tehran, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Khalili
authors.affiliation: epartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Hajikhani
authors.affiliation: epartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
authors.forename: Leila
authors.initials: L
authors.lastname: Barghi
authors.affiliation: epartment of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
authors.forename: Farnaz
authors.initials: F
authors.lastname: Mihandoust
keywords: 1-Tetralone derivatives; Acute and chronic pain; Formalin test; Ketamine; Phencyclidine; Tail immersion test