title: Fabrication and cyto-compatibility of Fe3O4/SiO2/graphene-CdTe QDs/CS nanocomposites for drug delivery.
abstract: Synthesis of magnetic Fe3O4/SiO2/graphene-CdTe QDs/chitosan nanocomposites (FGQCs) is investigated with respect to their potential of improving the drug loading content above that of magnetic/fluorescent bifunctional nanocomposites. To evaluate the performance of the FGQCs, their surface morphology was thoroughly assessed. The in vitro interaction between the FGQCs and heptoma cell line smmc-7721 cells was observed for the first time by TEM ultrathin section imaging. At an excitation wavelength of 365 nm, the graphene-QDs exhibit a strong luminescence in aqueous environments. The loading content and entrapment efficiency of the FGQCs were 70% and 50%, respectively. The cytotoxicity of this novel drug delivery system was evaluated in vitro using heptoma cell line smmc-7721 and quantified by the 3-(4,5-dimethylthiazol-z-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results show that FGQCs are a promising new multifunctional material for drug delivery in biological and medical applications.
authors.affiliation: Materials Science and Engineering College, Guilin University of Technology, Guilin 541004, China; Ministry-Province Jointly-Constructed Cultivation Base for State Key Laboratory of Processing for Non-ferrous Metal and Featured Materials, Guangxi Zhuang Autonomous Region, Guilin, China. Electronic address: gloujun123@gmail.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Ou
authors.affiliation: Materials Science and Engineering College, Guilin University of Technology, Guilin 541004, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.affiliation: Guangxi Medical University, Experimental Center of Medical Sciences, Nanning 530021, China.
authors.forename: Yuanjie
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Materials Science and Engineering College, Nanchang Hangkong University, Nanchang 330063, China.
authors.forename: Duosheng
authors.initials: D
authors.lastname: Li
authors.affiliation: Materials Science and Engineering College, Guilin University of Technology, Guilin 541004, China.
authors.forename: Yuming
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Research School of Engineering, Australian National University, Canberra 0200, ACT, Australia.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Qin
authors.affiliation: Research School of Engineering, Australian National University, Canberra 0200, ACT, Australia.
authors.forename: Z H
authors.initials: ZH
authors.lastname: Stachurski
authors.affiliation: Research School of Engineering, Australian National University, Canberra 0200, ACT, Australia.
authors.forename: Antonio
authors.initials: A
authors.lastname: Tricoli
authors.affiliation: Research School of Engineering, Australian National University, Canberra 0200, ACT, Australia.
authors.forename: Tina
authors.initials: T
authors.lastname: Zhang
mesh_terms: D001672:Biocompatible Materials / Q000494:pharmacology*; D019187:Cadmium Compounds / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D048271:Chitosan / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000494:pharmacology*; D006108:Graphite / Q000494:pharmacology*; D006801:Humans; D060328:Magnetic Phenomena; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D045663:Quantum Dots / Q000737:chemistry*; D012822:Silicon Dioxide / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence; D013691:Tellurium / Q000494:pharmacology
chemical_list: D001672:Biocompatible Materials; D019187:Cadmium Compounds; D005290:Ferric Compounds; C000499:ferric oxide; D012822:Silicon Dioxide; D006108:Graphite; D048271:Chitosan; D013691:Tellurium; C028337:cadmium telluride
keywords: CdTe QDs; Drug delivery; Graphene cytotocity; Luminescence; Multifunctional