title: [Purification and identification of impurities in vinorelbine bitartrate].
abstract: OBJECTIVE
  To investigate the chemical constituents of impurities in Vinorelbine Bitartrate.
  
  
  METHODS
  The impurities were isolated and purified by silica gel column chromatographies, and their structures were identified on the basis of their physicochemical properties and spectroscopic data.
  
  
  RESULTS
  Three compounds were isolated from Vinorelbine Bitartrate, and their structures were identified as Vinorelbine Bitartrate 3',4'-epoxy vinorelbine (1), 3',4'-oxidevinoerlbine (2) and 6'-N-mthyl-17-bormovinoerlbine (3).
  
  
  CONCLUSIONS
  Compounds 2 and 3 are obtained as the impurities in Vinorelbine Bitartrate for the first time.
authors.affiliation: Guangzhou Baiyunshan Hanfang Pharmaceutical Company Limited, Guangzhou 510970, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Huang
authors.affiliation: Guangzhou Baiyunshan Hanfang Pharmaceutical Company Limited, Guangzhou 510970, China.
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Chen
authors.affiliation: Guangzhou Baiyunshan Hanfang Pharmaceutical Company Limited, Guangzhou 510970, China.
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Huang
authors.affiliation: Guangzhou Baiyunshan Hanfang Pharmaceutical Company Limited, Guangzhou 510970, China.
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D004340:Drug Contamination; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine