title: Behçet's disease with severe destructive arthritis.
abstract: Abstract Behçet's disease is a systemic disease characterized by oral aphta, genital ulcers, and ocular lesions, and arthritic manifestations also appear to be common. However, this disease rarely produces loss of function or deformity in arthritic joints. We report the case of a 52-year-old woman with Behçet's disease who had a history of recurrent oral aphta, genital ulcerations, and intestinal lesions for almost 30 years. When she was about 30 years old, she began to notice significant morning stiffness and polyarthritis, and progressive destructive arthritic changes in the bilateral fingers, wrists, and left ankle. Behçet's disease with severe destructive arthritic changes is rare, and the underlying mechanism is still unknown.
authors.affiliation: Department of Orthopaedic Surgery, Institute of Rheumatology, Tokyo Women's Medical University , 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054 , Japan.
authors.forename: S
authors.initials: S
authors.lastname: Momohara
authors.forename: M
authors.initials: M
authors.lastname: Kuwahara
authors.forename: K
authors.initials: K
authors.lastname: Kawamura
authors.forename: T
authors.initials: T
authors.lastname: Mizumura
authors.forename: R
authors.initials: R
authors.lastname: Morimoto
authors.forename: T
authors.initials: T
authors.lastname: Tomatsu