title: Synthesis and Characterization of New Palladium(II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines.
abstract: The palladium(II) bis-chelate complexes of the type [Pd(TSC(1-5))2] (6-10), with their corresponding ligands 4-phenyl-1-(acetone)-thiosemicarbazone, HTSC(1) (1), 4-phenyl-1-(2'-chloro-benzaldehyde)-thiosemicarbazone, HTSC(2) (2), 4-phenyl-1-(3'-hydroxy-benzaldehyde)-thiosemicarbazone, HTSC(3) (3), 4-phenyl-1-(2'-naphthaldehyde)-thiosemicarbazone, HTSC(4) (4), and 4-phenyl-1-(1'-nitro-2'-naphthaldehyde)-thiosemicarbazone, HTSC(5) (5), were synthesized and characterized by elemental analysis and spectroscopic techniques (IR and (1)H- and (13)C-NMR). The molecular structure of HTSC(3), HTSC(4), and [Pd(TSC(1))2] (6) have been determined by single crystal X-ray crystallography. Complex 6 shows a square planar geometry with two deprotonated ligands coordinated to Pd(II) through the azomethine nitrogen and thione sulfur atoms in a cis arrangement. The in vitro cytotoxic activity measurements indicate that the palladium(II) complexes (IC50 = 0.01-9.87 μM) exhibited higher antiproliferative activity than their free ligands (IC50 = 23.48-70.86 and >250 μM) against different types of human tumor cell lines. Among all the studied palladium(II) complexes, the [Pd(TSC(3))2] (8) complex exhibited high antitumor activity on the DU145 prostate carcinoma and K562 chronic myelogenous leukemia cells, with low values of the inhibitory concentration (0.01 and 0.02 μM, resp.).
authors.affiliation: Facultad de Ingeniería Industrial, Universidad de Lima, Avenida Javier Prado Este Cuadra 46, Urbanización Monterrico, Lima 33, Peru.
authors.forename: Wilfredo
authors.initials: W
authors.lastname: Hernández
authors.affiliation: Facultad de Ingeniería Industrial, Universidad de Lima, Avenida Javier Prado Este Cuadra 46, Urbanización Monterrico, Lima 33, Peru.
authors.forename: Juan
authors.initials: J
authors.lastname: Paz
authors.affiliation: Facultad de Ciencias Naturales y Matemática, Universidad Nacional Federico Villarreal, Jr. Río Chepén s/n, El Agustino; Lima, Peru.
authors.forename: Fernando
authors.initials: F
authors.lastname: Carrasco
authors.affiliation: Laboratorio de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Avenida Honorio Delgado 430, Urbanización Ingeniería-San Martin de Porras, Lima 31, Peru.
authors.forename: Abraham
authors.initials: A
authors.lastname: Vaisberg
authors.affiliation: Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, CEDENNA, Olivos 1007, Casilla 233, Independencia, 8330492 Santiago, Chile.
authors.forename: Evgenia
authors.initials: E
authors.lastname: Spodine
authors.affiliation: Facultad de Ciencias Físicas y Matemáticas, Universidad de Chile, CEDENNA, 8370448 Santiago, Chile.
authors.forename: Jorge
authors.initials: J
authors.lastname: Manzur
authors.affiliation: Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.
authors.forename: Lothar
authors.initials: L
authors.lastname: Hennig
authors.affiliation: Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Sieler
authors.affiliation: Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.
authors.forename: Steffen
authors.initials: S
authors.lastname: Blaurock
authors.affiliation: Fakultät für Chemie und Mineralogie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.
authors.forename: Lothar
authors.initials: L
authors.lastname: Beyer