title: HMGCR is necessary for the tumorigenecity of esophageal squamous cell carcinoma and is regulated by Myc.
abstract: Hydroxymethylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme of mevalonate pathway, has been involved in the tumorigenesis of several tumor types. Our previous study has showed that statin, the inhibitor of HMGCR, inhibited the tumorigenecity of esophageal squamous cell carcinoma (ESCC) in vitro and in vivo. However, the function of HMGCR in the carcinogenesis of ESCC cells remains unknown. In this study, we have observed the up-regulation of HMGCR in ESCC tissues compared with the paired normal tissues. Over-expression of HMGCR in ESCC cells promoted cell growth and migration, while knockdown of the expression of HMGCR inhibited the growth, migration and colony formation of ESCC cells in vitro and in vivo. Furthermore, we found that oncogene Myc positively regulated the expression of HMGCR. Taken together, our study revealed the pivotal function of HMGCR and mevalonate pathway in the progression of ESCC and supported the clinical application of statin.
authors.affiliation: Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.
authors.forename: Chenxi
authors.initials: C
authors.lastname: Zhong
authors.forename: Limin
authors.initials: L
authors.lastname: Fan
authors.forename: Feng
authors.initials: F
authors.lastname: Yao
authors.forename: Jianxin
authors.initials: J
authors.lastname: Shi
authors.forename: Wentao
authors.initials: W
authors.lastname: Fang
authors.forename: Heng
authors.initials: H
authors.lastname: Zhao
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D004938:Esophageal Neoplasms / Q000209:etiology*; D000077277:Esophageal Squamous Cell Carcinoma; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D016259:Genes, myc / Q000502:physiology*; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000502:physiology*; D008798:Mevalonic Acid / Q000378:metabolism
chemical_list: C553220:HMGCR protein, human; D006903:Hydroxymethylglutaryl CoA Reductases; D048049:Extracellular Signal-Regulated MAP Kinases; D008798:Mevalonic Acid