title: Nonlinear trajectory of GFR in children before RRT.
abstract: GFR decline in patients with CKD has been widely approximated using linear models, but this linearity assumption is not well validated. We conducted a matched case-control study in children from the Chronic Kidney Disease in Children (CKiD) cohort ages 1-16 years with mild to moderate CKD to assess whether GFR decline follows a nonlinear trajectory as CKD approaches ESRD. Children (n=125) who initiated RRT (cases) during follow-up were individually matched by CKD stage at baseline and glomerular/nonglomerular diagnosis with children (n=125) who remained RRT-free when the corresponding case initiated RRT (controls). GFR trajectories were compared using log-linear and piecewise log-linear mixed effects models adjusted for baseline characteristics. From study entry to 18 months before RRT, GFR declined 7% faster among cases compared with controls. However, GFR declined 26% faster among cases compared with controls (P<0.001) during the 18 months before RRT. Nonlinearity in the rate of kidney function loss, which was shown in this cohort, may preclude accurate clinical prediction of the timing of RRT and adequate patient preparation. This study should prompt the characterization of predictive factors that may contribute to an acceleration of kidney function decline.
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;
authors.forename: Yichen
authors.initials: Y
authors.lastname: Zhong
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;
authors.forename: Alvaro
authors.initials: A
authors.lastname: Muñoz
authors.affiliation: Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York;
authors.forename: George J
authors.initials: GJ
authors.lastname: Schwartz
authors.affiliation: Department of Pediatrics, Children's Mercy Hospital and Clinics, Kansas City, Missouri; and.
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Warady
authors.affiliation: Departments of Pediatrics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Susan L
authors.initials: SL
authors.lastname: Furth
authors.affiliation: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland; aabraham@jhsph.edu.
authors.forename: Alison G
authors.initials: AG
authors.lastname: Abraham
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D018450:Disease Progression; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D016014:Linear Models; D008297:Male; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology* / Q000628:therapy*; D017582:Renal Replacement Therapy / Q000379:methods* / Q000639:trends