title: Identification and determination of ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method.
abstract: Conditions for determination of: ketotifen hydrogen fumarate, azelastine hydrochloride, dimetindene maleate and promethazine hydrochloride by densitometric method in substances and pharmaceuticals were provided. Maximum wavelenghts were: 228 nm for ketotifen hydrogen fumarate, 295 nm for azelastine hydrochloride, 265 nm for dimetindene maleate and 255 nm for promethazine hydrochloride. The limits of quantification were in the ranges of 0.2-5 microg/spot. The statistical data showed adequate accuracy and precision of developed methods.
authors.affiliation: Department of Basic and Applied Pharmacy, National Medicines Institute, 30/34 Chełmska St. 00-725 Warszawa, Poland. ewyszomirska@il.waw.pl
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Wyszomirska
authors.affiliation: Department of Basic and Applied Pharmacy, National Medicines Institute, 30/34 Chełmska St. 00-725 Warszawa, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Czerwińska
authors.affiliation: Department of Basic and Applied Pharmacy, National Medicines Institute, 30/34 Chełmska St. 00-725 Warszawa, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Kublin
authors.affiliation: Department of Basic and Applied Pharmacy, National Medicines Institute, 30/34 Chełmska St. 00-725 Warszawa, Poland.
authors.forename: Aleksander P
authors.initials: AP
authors.lastname: Mazurek
mesh_terms: D002138:Calibration; D002855:Chromatography, Thin Layer / Q000592:standards; D003720:Densitometry / Q000592:standards; D004115:Dimethindene / Q000032:analysis*; D006634:Histamine H1 Antagonists / Q000032:analysis*; D007665:Ketotifen / Q000032:analysis; D057230:Limit of Detection; D010793:Phthalazines / Q000032:analysis*; D011398:Promethazine / Q000032:analysis*; D012044:Regression Analysis; D015203:Reproducibility of Results
chemical_list: D006634:Histamine H1 Antagonists; D010793:Phthalazines; D004115:Dimethindene; D011398:Promethazine; D007665:Ketotifen; C020976:azelastine