title: Reconstruction of the human cerebral cortex robust to white matter lesions: method and validation.
abstract: Cortical atrophy has been reported in a number of diseases, such as multiple sclerosis and Alzheimer's disease, that are also associated with white matter (WM) lesions. However, most cortical reconstruction techniques do not account for these pathologies, thereby requiring additional processing to correct for the effect of WM lesions. In this work, we introduce CRUISE(+), an automated process for cortical reconstruction from magnetic resonance brain images with WM lesions. The process extends previously well validated methods to allow for multichannel input images and to accommodate for the presence of WM lesions. We provide new validation data and tools for measuring the accuracy of cortical reconstruction methods on healthy brains as well as brains with multiple sclerosis lesions. Using this data, we validate the accuracy of CRUISE(+) and compare it to another state-of-the-art cortical reconstruction tool. Our results demonstrate that CRUISE(+) has superior performance in the cortical regions near WM lesions, and similar performance in other regions.
authors.affiliation: Image Analysis and Communication Laboratory, Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland; Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for Advancement of Military Medicine, Bethesda, Maryland.
authors.forename: Navid
authors.initials: N
authors.lastname: Shiee
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Bazin
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Cuzzocreo
authors.forename: Chuyang
authors.initials: C
authors.lastname: Ye
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Kishore
authors.forename: Aaron
authors.initials: A
authors.lastname: Carass
authors.forename: Peter A
authors.initials: PA
authors.lastname: Calabresi
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Reich
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Prince
authors.forename: Dzung L
authors.initials: DL
authors.lastname: Pham
mesh_terms: D000328:Adult; D001284:Atrophy; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D056784:Leukoencephalopathies / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012984:Software
keywords: WM lesions; cortical reconstruction; cortical thickness; lesion segmentation; multiple sclerosis