title: Treatment of nail psoriasis with intralesional triamcinolone acetonide using a needle-free jet injector: a prospective trial.
abstract: BACKGROUND
  Treating nail psoriasis is challenging. Corticosteroid matrix injection with needle is a conventional treatment but pain is often a limitation.
  
  
  OBJECTIVE
  Evaluate efficacy and safety of triamcinolone acetonide needle-free injection with the Med-Jet MBX in psoriatic fingernail.
  
  
  METHODS
  Seventeen patients were enrolled between January 2012 and January 2013. Four treatments sessions were scheduled every 4 ± 1 weeks. Clinical efficacy was evaluated according to Nail Psoriasis Severity Index (NAPSI) score of target nail differences before and after the treatment.
  
  
  RESULTS
  Mean baseline NAPSI score was 6.5 on an 8-point scale (95% confidence interval [CI] 5.652-7.348) and mean final NAPSI score was 2.8 on an 8-point scale (95% CI 1.859-3.741), demonstrating statistically significant treatment efficacy (p = .0007). NAPSI score for target nail from baseline to end of treatment was decreased by 46.25%.
  
  
  CONCLUSIONS
  Treatment with triamcinolone acetonide delivered by Med-Jet MBX is a safe, minimally painful and effective treatment for nail psoriasis.
authors.forename: Melissa
authors.initials: M
authors.lastname: Nantel-Battista
authors.forename: Vincent
authors.initials: V
authors.lastname: Richer
authors.forename: Isabelle
authors.initials: I
authors.lastname: Marcil
authors.forename: Antranik
authors.initials: A
authors.lastname: Benohanian
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007271:Injections, Intradermal; D008297:Male; D008875:Middle Aged; D009260:Nail Diseases / Q000188:drug therapy* / Q000473:pathology; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D014222:Triamcinolone Acetonide / Q000008:administration & dosage
chemical_list: D007166:Immunosuppressive Agents; D014222:Triamcinolone Acetonide