title: MGMT Leu84Phe gene polymorphism and lung cancer risk: a meta-analysis.
abstract: Many studies have examined the association between the MGMT Leu84Phe polymorphism gene polymorphisms and lung cancer risk in various populations, but their results have been inconsistent. To assess this relationship more precisely, a meta-analysis was performed. The PubMed and CNKI database was searched for case-control studies published up to Nov. 2013. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. Ultimately, 7 studies, comprising 3,094 lung cancer cases and 4,216 controls, were included. Overall, for (Phe/Phe+Phe/Leu) versus Leu/Leu, the pooled OR for all studies was 1.08 (95% CI = 0.97-1.21 P = 0.518 for heterogeneity); for Phe/Phe versus Leu/Leu and Phe versus Leu, the pooled OR was 1.10 (95% CI = 0.99-1.21 P = 0.445 for heterogeneity) and 1.46 (95% CI = 1.05-2.02 P = 0.352 for heterogeneity), respectively. In the stratified analysis by ethnicity, significantly risks were found among Caucasians not in Asians. This meta-analysis suggests that the MGMT Leu84Phe polymorphisms are associated with lung cancer risk among Caucasians not in Asians.
authors.affiliation: Department of Emergency, Jiangyin Hospital of Traditional Chinese Medicine, Nanjing Traditional Chinese Medicine University, No. 130 Renmingzhong Road, Jiangyin, 214400, Jiangsu, China.
authors.forename: Zhi-xiong
authors.initials: ZX
authors.lastname: Qiu
authors.forename: Fei
authors.initials: F
authors.lastname: Xue
authors.forename: Xuan-feng
authors.initials: XF
authors.lastname: Shi
authors.forename: Xiao
authors.initials: X
authors.lastname: He
authors.forename: Hui-ni
authors.initials: HN
authors.lastname: Ma
authors.forename: Lan
authors.initials: L
authors.lastname: Chen
authors.forename: Pin-zhong
authors.initials: PZ
authors.lastname: Chen
mesh_terms: D044466:Asian People; D016022:Case-Control Studies; D015254:DNA Modification Methylases / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012306:Risk; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D044465:White People
chemical_list: D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes