title: Total synthesis of (+)-seimatopolide A.
abstract: Total synthesis of 10-membered lactone (+)-seimatopolide A is presented from furfural. Key reactions in the present strategy include the effective use of furan as a E-but-2-ene-1,4-dione surrogate, Nagao acetate aldol reaction, and Shiina lactonization.
authors.affiliation: Department of Organic Chemistry, Indian Institute of Science , Bangalore 560012, Karnataka, India.
authors.forename: Kavirayani R
authors.initials: KR
authors.lastname: Prasad
authors.forename: Omkar
authors.initials: O
authors.lastname: Revu
mesh_terms: D005663:Furans / Q000737:chemistry*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D005663:Furans; D007783:Lactones; D018942:Macrolides; C573610:seimatopolide A; C039281:furan