title: Investigation on reference intervals and regional differences of platelet indices in healthy Chinese Han adults.
abstract: BACKGROUND
  Reference intervals are important for interpretation of clinical laboratory tests. The platelet (PLT) indices such as the mean platelet volume (MPV) and platelet distribution width (PDW) are newer hematological parameters, which have been recently reported as clinically valuable biomarkers. However, there are not many studies that have estimated the reference intervals for these parameters in healthy Chinese Han adults.
  
  
  OBJECTIVE
  The objectives of this study were to establish reference values of PLT indices [including PLT count, MPV, PDW, platelet-large cell ratio (P-LCR), and plateletcrit (Pct)] for healthy Chinese Han adults. We also aimed to determine the region-based differences of PLT indices in China.
  
  
  METHODS
  A total of 4,642 volunteers with a mean age of 43 were recruited from six regions of China. PLT indices were performed on Sysmex XE-2100 hematology analyzers, whose traceability was well verified.
  
  
  RESULTS
  There were significant region-based differences for all PLT indices. Reference people in Chengdu had the lowest mean PLT count and Pct, but the highest MPV, PDW, and P-LCR among the six regions. Therefore, we derived the reference intervals in Chinese Han population excluding Chengdu reference people for PLT indices as PLT count: (127-341) × 10(9)/l; MPV: (9.20-13.30) fl; PDW: 9.90-19.00%; P-LCR: 18.10-52.00%; Pct: 16.00-41.00%.
  
  
  CONCLUSIONS
  Region-specific reference intervals are essential as there were statistically significant region-related differences in the PLT parameters. The reference intervals established in this study differed from the existing reference values. Chengdu region may need proper specific reference ranges, which apply to their people, for all PLT parameters.
authors.affiliation: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Jiang
authors.initials: J
authors.lastname: Hong
authors.forename: Zhao
authors.initials: Z
authors.lastname: Min
authors.forename: Pan
authors.initials: P
authors.lastname: Bai-shen
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jie
authors.forename: Peng
authors.initials: P
authors.lastname: Ming-ting
authors.forename: Huang
authors.initials: H
authors.lastname: Xian-zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Xiao-ke
authors.forename: Wang
authors.initials: W
authors.lastname: Lan-lan
authors.forename: Zhang
authors.initials: Z
authors.lastname: Xin
authors.forename: Guo
authors.initials: G
authors.lastname: Wei
authors.forename: Qiao
authors.initials: Q
authors.lastname: Rui
authors.forename: Chen
authors.initials: C
authors.lastname: Wen-xiang
authors.forename: Wu
authors.initials: W
authors.lastname: Xin-zhong
authors.forename: Ma
authors.initials: M
authors.lastname: Yue-yun
authors.forename: Shang
authors.initials: S
authors.lastname: Hong
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D044466:Asian People / Q000208:ethnology; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D003710:Demography; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D010976:Platelet Count / Q000379:methods / Q000592:standards; D012016:Reference Values; D015203:Reproducibility of Results; D055815:Young Adult
keywords: MPV; P-LCR; PDW; PLT count; Pct; platelet indices; reference intervals