title: Introduction of a mathematical model for optimizing the drug release in the patient's body.
abstract: BACKGROUND
  Drug release in a patient's body is of particular interest to the pharmaceutical industry. One of the most essential types of drug release is the gradual release based on a behavior, which is called a profile or modified release. The investigation of the time-oriented quality characteristic is one of the newest topics in the area of product design. There are already several approaches addressing this issue. In this paper, a mathematical model is proposed to find the suitable values of the controllable factors in a drug to achieve the profile of the drug release in the patient's body.
  
  
  RESULTS
  The proposed method has several advantages over the existing methods.
  
  
  CONCLUSIONS
  The authors feel that by adjusting the control factors during the production process the drug release profile become closer to the reference profile.
authors.affiliation: Department of Industrial Engineering, K,N, Toosi University of Technology, No 7, Pardis St,, Mollasadra Ave,, Tehran, Iran. mrnabatchian@dena.kntu.ac.ir.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Nabatchian
authors.forename: Hamid
authors.initials: H
authors.lastname: Shahriari
authors.forename: Mona
authors.initials: M
authors.lastname: Shahriari