title: [A case of small-sized lung cancer complicated by sarcoidosis].
abstract: A woman in her seventies presented with bilateral hilar and mediastinal lymphadenopathy with high fluorodeoxyglucose (FDG) uptake by positron emission tomography (PET)-computed tomography (CT), small lung nodules, and uveitis. Mediastinoscopic biopsy yielded a histological finding of epithelioid granuloma and a diagnosis of sarcoidosis. A nodule, 1 cm in diameter, in the right middle lobe with moderate FDG uptake was deemed to be a sarcoidosis lesion. Steroid therapy for uveitis resulted in shrinkage of the hilar and mediastinal lymph nodes; however, 1 year later the nodule in the right middle lobe had enlarged to 2 cm in diameter. Right middle lobectomy was performed, and a histological diagnosis of lung squamous cell carcinoma was made. Six months later, right pretracheal lymphadenopathy with high FDG uptake was noted and was proved to be a metastatic squamous cell carcinoma by endobronchial ultrasound-guided transbronchial needle aspiration( EBUS-TBNA). After 7 courses of chemotherapy with docetaxel, the target lesion shrank and its abnormal FDG uptake disappeared. Small-sized lung cancer could be missed when complicated by sarcoidosis because the latter produces a background of multiple lesions, so careful diagnostic imaging and follow-up should be performed in patients diagnosed as having sarcoidosis.
authors.affiliation: Dept. of Surgery, Suita Municipal Hospital.
authors.forename: Hideoki
authors.initials: H
authors.lastname: Yokouchi
authors.forename: Masaki
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Takeaki
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Fumio
authors.initials: F
authors.lastname: Tsuji
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Tamai
authors.forename: Yuma
authors.initials: Y
authors.lastname: Wada
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Makino
authors.forename: Chikara
authors.initials: C
authors.lastname: Ebisui
authors.forename: Kohei
authors.initials: K
authors.lastname: Murata
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000188:drug therapy; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D012507:Sarcoidosis / Q000150:complications*; D043823:Taxoids / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel