title: Severe fever with thrombocytopenia syndrome, Shandong Province, China, 2011.
abstract: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China. The incidence and clinical and laboratory characteristics of SFTS are not clearly defined. During May 22-October 2, 2011, a total of 24 patients with fever, thrombocytopenia, and leukopenia were clinically diagnosed as having SFTS in Yiyuan County, Shandong Province, China. We conducted laboratory tests for these SFTS patients. SFTS virus (SFTSV) infection was confirmed in 22 patients by using reverse transcription PCR and ELISA by acute-phase and convalescent-phase serum samples. Clinical and laboratory manifestations included fever (100%), gastrointestinal symptoms (91%), myalgia (55%), chills (41%), thrombocytopenia (100%), and leukopenia (95%).
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Wen
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Shenyong
authors.initials: S
authors.lastname: Zhai
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Chi
authors.forename: Feng
authors.initials: F
authors.lastname: Cui
authors.forename: Dongxu
authors.initials: D
authors.lastname: Wang
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Wang
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Shoufeng
authors.initials: S
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.forename: Xue-Jie
authors.initials: XJ
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000266:history; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000821:virology; D062306:Geography, Medical; D049674:History, 21st Century; D006801:Humans; D007970:Leukopenia / Q000453:epidemiology / Q000821:virology; D008297:Male; D008875:Middle Aged; D058889:Molecular Typing; D010217:Phlebotomus Fever / Q000453:epidemiology* / Q000266:history; D016856:Phlebovirus / Q000145:classification* / Q000235:genetics; D012621:Seasons; D018571:Sentinel Surveillance; D012703:Serotyping; D013921:Thrombocytopenia / Q000453:epidemiology / Q000821:virology
keywords: China; SFTS; SFTSV; Shandong Province; bunyavirus; clinical characteristics; epidemiology; laboratory characteristics; severe fever with thrombocytopenia syndrome; severe fever with thrombocytopenia syndrome virus; viruses