title: Detection of drug effects on gastric emptying and contractility using a wireless motility capsule.
abstract: BACKGROUND
  A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility.
  
  
  METHODS
  15 healthy adults were administered in random order saline, erythromycin IV 150 mg, or morphine IV 0.05 mg/kg BW. Subjects ate a standard meal after each infusion, and subsequently ingested the motility capsule. Data were recorded for 8 hours, and the results were analyzed using the manufacturer's software.
  
  
  RESULTS
  GET was significantly faster after erythromycin than either saline or morphine. Morphine tended to delay emptying of the capsule compared to saline. There was a trend toward a greater frequency of gastric contractions with erythromycin and a reduced frequency of gastric contractions with morphine that did not reach statistical significance.
  
  
  CONCLUSIONS
  A wireless motility capsule successfully detected acceleration of gastric emptying induced by erythromycin, and retardation of gastric motility caused by morphine. These results indicate that a wireless motility capsule is a promising technique to assess pharmacologic effects on gastric transit and contractility and aid in development of drugs for gastric motor disorders.
authors.forename: Inna
authors.initials: I
authors.lastname: Rozov-Ung
authors.forename: Amjad
authors.initials: A
authors.lastname: Mreyoud
authors.forename: John
authors.initials: J
authors.lastname: Moore
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Wilding
authors.forename: Elias
authors.initials: E
authors.lastname: Khawam
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Lackner
authors.forename: John R
authors.initials: JR
authors.lastname: Semler
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, University at Buffalo, State University of New York, 462 Grider, Rm 132-7, Buffalo, NY 14215, USA. mdsitrin@buffalo.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Sitrin
mesh_terms: D000328:Adult; D000368:Aged; D001831:Body Temperature; D053704:Capsule Endoscopy / Q000379:methods*; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation*; D009020:Morphine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D011312:Pressure; D012965:Sodium Chloride / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D059015:Wireless Technology; D055815:Young Adult
chemical_list: D012965:Sodium Chloride; D004917:Erythromycin; D009020:Morphine