title: Endothelial caveolin-1 plays a major role in the development of atherosclerosis.
abstract: Clinical studies have established the important impact of atherosclerotic disease in Western societies. This disease is characterized by the accumulation of lipids and the migration of various cell types in the sub-endothelial space of blood vessels. As demonstrated by many studies, endothelial cells play an essential role in the development of this disease. The endothelium acts as a gatekeeper of blood vessel integrity and cardiovascular health status. For instance, the transfer of lipids via the transport of lipoproteins in the arterial intima is believed to be mediated by endothelial cells through a process termed transcytosis. In addition, lipoproteins that accumulate in the sub-endothelial space may also be modified, in a process that can direct the activation of endothelial cells. These steps are essential for the initiation of an atherosclerotic plaque and may be mediated, at least in part, by caveolae and their associated protein caveolin-1. In the present study, we evaluate the role of caveolin-1/caveolae in the regulation of these two steps in endothelial cells. Our data clearly demonstrate that caveolin-1 is involved in the regulation of lipoprotein transcytosis across endothelial cells and in the regulation of vascular inflammation.
authors.affiliation: Manchester Breast Centre & Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; Institute of Cancer Sciences; Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
authors.forename: Stephanos
authors.initials: S
authors.lastname: Pavlides
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Gutierrez-Pajares
authors.forename: Jeannette
authors.initials: J
authors.lastname: Iturrieta
authors.forename: Michael P
authors.initials: MP
authors.lastname: Lisanti
authors.forename: Philippe G
authors.initials: PG
authors.lastname: Frank
mesh_terms: D000418:Albumins / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000378:metabolism / Q000473:pathology; D050197:Atherosclerosis / Q000378:metabolism* / Q000473:pathology*; D021941:Caveolae / Q000378:metabolism; D051242:Caveolin 1 / Q000378:metabolism*; D015536:Down-Regulation; D004705:Endocytosis; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D020868:Gene Silencing; D061307:Human Umbilical Vein Endothelial Cells / Q000378:metabolism / Q000473:pathology; D007249:Inflammation / Q000473:pathology; D008077:Lipoproteins, LDL / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D016328:NF-kappa B / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000418:Albumins; D051242:Caveolin 1; D008077:Lipoproteins, LDL; D016328:NF-kappa B; D034741:RNA, Small Interfering