title: Linezolid-induced near-fatal serotonin syndrome during escitalopram therapy: case report and review of literature.
abstract: Linezolid is a synthetic antimicrobial agent of the oxazolidinone class with weak, nonspecific inhibitor of monoamine oxidase enzymes. Concomitant therapy with an adrenergic or serotonergic agent or consuming tyramine (>100 mg/day) may induce serotonin syndrome (SS). We present a case report of near-fatal adverse interaction between linezolid and escitalopram inducing SS in a 65-year-old woman with sepsis, under empirical antibiotic treatment. This report also summarizes the current relevant literature as identified via PubMed, EMBASE, and PsycINFO, supplemented with a manual search of cross references.
authors.affiliation: Department of Psychiatry, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India.
authors.forename: Ranganath R
authors.initials: RR
authors.lastname: Kulkarni
authors.affiliation: Department of Forensic Medicine and Toxicology, SDM College of Medical Sciences and Hospital, Dharwad, Karnataka, India.
authors.forename: Pratibha R
authors.initials: PR
authors.lastname: Kulkarni
keywords: Adverse event; escitalopram; linezolid; serotonin syndrome