title: Copper immobilized on nanosilica triazine dendrimer (Cu(II)-TD@nSiO2)-catalyzed regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles and bis- and tris-triazoles via a one-pot multicomponent click reaction.
abstract: An efficient, atom-economical, and regioselective synthesis of a wide range of 1,4-disubstituted 1,2,3-triazoles in excellent yields has been achieved via a one-pot three-component reaction of alkynes and sodium azide with organic halides or α-bromo ketones catalyzed by Cu(II)-TD@nSiO2/sodium ascorbate at room temperature. This catalytic system also showed excellent activity in the synthesis of bis- and tris-1,4-substituted 1,2,3-triazoles. Moreover, the catalyst could be recycled and reused for seven cycles without any loss in its catalytic activity.
authors.affiliation: Department of Chemistry, Catalysis Division, University of Isfahan , Isfahan 81746-73441, Iran.
authors.forename: Mahboobeh
authors.initials: M
authors.lastname: Nasr-Esfahani
authors.forename: Iraj
authors.initials: I
authors.lastname: Mohammadpoor-Baltork
authors.forename: Ahmad R
authors.initials: AR
authors.lastname: Khosropour
authors.forename: Majid
authors.initials: M
authors.lastname: Moghadam
authors.forename: Valiollah
authors.initials: V
authors.lastname: Mirkhani
authors.forename: Shahram
authors.initials: S
authors.lastname: Tangestaninejad
authors.forename: Hadi
authors.initials: H
authors.lastname: Amiri Rudbari