title: Risk factors of CMV infection in patients after umbilical cord blood transplantation: a multicenter study in China.
abstract: OBJECTIVE
  This retrospective study examined risk factors for cytomegalovirus (CMV) infection after umbilical cord blood transplantation (UCBT) and the impact of CMV infection on patient survival.
  
  
  METHODS
  In all 176 patients, plasma CMV DNA was negative prior to the transplantation, and examined twice a week for 100 d, and then once weekly for additional 300 d. Preemptive antiviral therapy (ganciclovir or foscarnet) was started in patients with >1,000/mL copies of CMV DNA but no full-blown CMV disease, and was discontinued upon two consecutive negative reports of blood CMV DNA test. The survival and risk factors for CMV infection or disease were examined using logistic regression.
  
  
  RESULTS
  CMV infection developed in 71% (125/176) of the patients, with a median onset of 32 d. Four patients (2.3%) developed CMV disease. Neither the 5-year overall survival (OS) nor event-free survival (EFS) differed significantly in infected patients vs. those with no infection (59.4% vs. 64.8%, P=0.194; 53.4% vs. 59.1%, P=0.226). A stepwise multivariate analysis indicated an association of CMV infection with age, high-dose glucocorticoids, the number of transplanted CD34(+) cells, and the number of platelet transfusion, but not with gender, the conditioning regimen, and the day of neutrophil recovery and chronic graft-versus-host disease (cGVHD).
  
  
  CONCLUSIONS
  CMV infection is very common after UCBT, but does not seem to affect long-term survival with preemptive antiviral treatment.
authors.affiliation: Shandong University, School of Medicine, Jinan 250012, China; ; Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Tong
authors.affiliation: Shandong University, School of Medicine, Jinan 250012, China; ; Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Zimin
authors.initials: Z
authors.lastname: Sun
authors.affiliation: Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Huilan
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Liangquan
authors.initials: L
authors.lastname: Geng
authors.affiliation: Shandong University, School of Medicine, Jinan 250012, China; ; Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Changcheng
authors.initials: C
authors.lastname: Zheng
authors.affiliation: Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Baolin
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Kaidi
authors.initials: K
authors.lastname: Song
authors.affiliation: Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Yao
authors.affiliation: Department of Hematology, Anhui Provincial Hospital, Anhui Medical University, Hefei 230001, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
keywords: Cytomegalovirus (CMV); risk factor; umbilical cord blood transplantation (UCBT)