title: Prevalence of drug resistance in human immunodeficiency virus type 1-infected treatment-naive children in Pune, India.
abstract: Abstract We report the presence of drug resistance mutations in 7.4% (2/27) of the treatment-naive, HIV-1-infected children in Pune, India, who had HIV-1 RNA levels >1,000 copies/ml. Nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations, namely A98G and K103N, were observed in two separate sequences. In addition, three study sequences displayed three separate HIV-1 protease minor resistance mutations-L10I, A71T, and T74S. These preliminary data from Pune, India, reporting the presence of HIVDR in treatment-naive, HIV-1-infected children, reinforces the need to conduct large-scale studies to assess the prevalence of primary HIVDR in the pediatric population, which in turn will aid in planning protocols and policies related to antiretroviral treatment for the pediatric population.
authors.affiliation: 1 Department of Microbiology, Government Medical College , Haldwani, India .
authors.forename: Mukesh
authors.initials: M
authors.lastname: Kumar
authors.forename: Sourav
authors.initials: S
authors.lastname: Sen
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Gupta
authors.forename: Devidas
authors.initials: D
authors.lastname: Chaturbhuj
authors.forename: Srikanth P
authors.initials: SP
authors.lastname: Tripathy
authors.forename: Ramesh S
authors.initials: RS
authors.lastname: Paranjape
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D015995:Prevalence; D017422:Sequence Analysis, DNA