title: Mechanism of resistance to an antitubercular 2-thiopyridine derivative that is also active against Burkholderia cenocepacia.
abstract: The discovery of new compounds that are able to inhibit the growth of Burkholderia cenocepacia is of primary importance for cystic fibrosis patients. Here, the mechanism of resistance to a new pyridine derivative already shown to be effective against Mycobacterium tuberculosis and to have good activity toward B. cenocepacia was investigated. Increased expression of a resistance-nodulation-cell division (RND) efflux system was detected in the resistant mutants, thus confirming their important roles in B. cenocepacia antibiotic resistance.
authors.affiliation: Dipartimento di Biologia e Biotecnologie L. Spallanzani, Università degli Studi di Pavia, Pavia, Italy.
authors.forename: Viola C
authors.initials: VC
authors.lastname: Scoffone
authors.forename: Francesca
authors.initials: F
authors.lastname: Spadaro
authors.forename: Claudia
authors.initials: C
authors.lastname: Udine
authors.forename: Vadim
authors.initials: V
authors.lastname: Makarov
authors.forename: Marco
authors.initials: M
authors.lastname: Fondi
authors.forename: Renato
authors.initials: R
authors.lastname: Fani
authors.forename: Edda
authors.initials: E
authors.lastname: De Rossi
authors.forename: Giovanna
authors.initials: G
authors.lastname: Riccardi
authors.forename: Silvia
authors.initials: S
authors.lastname: Buroni
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D057508:Burkholderia cenocepacia / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000235:genetics; D011725:Pyridines / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D001426:Bacterial Proteins; D011725:Pyridines; C029347:2-thiopyridine