title: A case of acquired hemophilia caused by factor VIII inhibitor with rheumatoid arthritis, successfully treated with immunosuppressive treatment and recombinant activated factor VII.
abstract: Abstract We report the case of a patient who presented with acquired hemophilia associated with rheumatoid arthritis. The patient's factor VIII activity was less than 1% and factor VIII inhibitor was detected. Based on the blood analysis, the patient was diagnosed as having the factor VIII inhibitor. She was successfully treated with prednisolone, cyclophosphamide, and gammaglobulin to suppress the factor VIII inhibitor, and the administration of recombinant activated factor VII was effective in controlling severe bleeding episodes.
authors.affiliation: Department of Allergy and Rheumatology, Japanese Red Cross Medical Center , 4-1-22 Hiroo, Shibuya-ku, Tokyo 150-8935 , Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Sato
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Hagiwara
authors.forename: Junnichi
authors.initials: J
authors.lastname: Chikazoe
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Akiyama