title: Endocytic pH-triggered degradation of nanoengineered multilayer capsules.
abstract: The synthesis of cross-linker free layer-by-layer (LbL) capsules that solely utilize cellular pH variations as a trigger to specifically deconstruct and subsequently release cargo in cells is reported. These capsules demonstrate retention of water-soluble therapeutic molecules as small as 500 Da at extracellular pH. Triggered capsule degradation and release of cargo is observed within 30 min of cell uptake.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Kang
authors.initials: K
authors.lastname: Liang
authors.forename: Georgina K
authors.initials: GK
authors.lastname: Such
authors.forename: Angus P R
authors.initials: AP
authors.lastname: Johnston
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Zhu
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ejima
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Richardson
authors.forename: Jiwei
authors.initials: J
authors.lastname: Cui
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D057846:Cell-Penetrating Peptides / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D005110:Extracellular Space / Q000737:chemistry; D005240:Feasibility Studies; D005434:Flow Cytometry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D042541:Intracellular Space / Q000737:chemistry*; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D008970:Molecular Weight; D053769:Nanocapsules / Q000737:chemistry*; D010767:Phosphorylcholine / Q000031:analogs & derivatives / Q000737:chemistry; D011109:Polymethacrylic Acids / Q000737:chemistry; D013997:Time Factors
chemical_list: D057846:Cell-Penetrating Peptides; D004337:Drug Carriers; D053769:Nanocapsules; D011109:Polymethacrylic Acids; C511861:poly(2-(diisopropylamino)ethyl methacrylate); C500651:poly(MPC-co-MA); D010767:Phosphorylcholine
keywords: biomaterials; drug delivery; layer-by-layer; nanotechnology; polymer capsules