title: Signaling pathways bridging fate determination of neural crest cells to glial lineages in the developing peripheral nervous system.
abstract: Fate determination of neural crest cells is an essential step for the development of different crest cell derivatives. Peripheral glia development is marked by the choice of the neural crest cells to differentiate along glial lineages. The molecular mechanism underlying fate acquisition is poorly understood. However, recent advances have identified different transcription factors and genes required for the complex instructive signaling process that comprise both local environmental and cell intrinsic cues. Among others, at least the roles of Sox10, Notch, and neuregulin 1 have been documented in both in vivo and in vitro models. Cooperative interactions of such factors appear to be necessary for the switch from multipotent neural crest cells to glial lineage precursors in the peripheral nervous system. This review summarizes recent advances in the understanding of fate determination of neural crest cells into different glia subtypes, together with the potential implications in regenerative medicine.
authors.affiliation: Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Sokoine University of Agriculture, P.O. Box 3016, Chuo Kikuu, Morogoro, Tanzania. Electronic address: kipanyula@suanet.ac.tz.
authors.forename: Maulilio John
authors.initials: MJ
authors.lastname: Kipanyula
authors.affiliation: Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Sokoine University of Agriculture, P.O. Box 3016, Chuo Kikuu, Morogoro, Tanzania.
authors.forename: Wahabu Hamisi
authors.initials: WH
authors.lastname: Kimaro
authors.affiliation: Neurology Department, Yaoundé Central Hospital, Department of Internal Medicine and Specialties, University of Yaoundé I, P.O. Box 1937, Yaoundé, Cameroon.
authors.forename: Faustin N
authors.initials: FN
authors.lastname: Yepnjio
authors.affiliation: Department of Optometry, College of Applied Medical Sciences, Qassim University, 51452 Buraydah, Saudi Arabia.
authors.forename: Yousef H
authors.initials: YH
authors.lastname: Aldebasi
authors.affiliation: Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, 51452 Buraydah, Saudi Arabia.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Farahna
authors.affiliation: Department of Medicine, University of Ngaoundéré, P.O. Box 454, Ngaoundéré, Cameroon.
authors.forename: Armel Herve
authors.initials: AH
authors.lastname: Nwabo Kamdje
authors.affiliation: Department of Anatomy and Histology, College of Medicine, Qassim University, 51452 Buraydah, Saudi Arabia.
authors.forename: Eltuhami M
authors.initials: EM
authors.lastname: Abdel-Magied
authors.affiliation: Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, 51452 Buraydah, Saudi Arabia. Electronic address: paul.seke@gmail.com.
authors.forename: Paul Faustin
authors.initials: PF
authors.lastname: Seke Etet
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D009432:Neural Crest / Q000166:cytology / Q000378:metabolism*; D020890:Neuregulin-1 / Q000378:metabolism; D009457:Neuroglia / Q000166:cytology / Q000378:metabolism*; D017933:Peripheral Nervous System / Q000378:metabolism*; D051880:Receptors, Notch / Q000378:metabolism; D055757:SOXE Transcription Factors / Q000378:metabolism; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D020890:Neuregulin-1; D051880:Receptors, Notch; D055757:SOXE Transcription Factors
keywords: Embryonic stem cells; Glia development; Neural crest cells; Neuregulin-1; Notch; Sox 10