title: [Evaluation of dialysis in patients with end-stage renal disease by salivary urea, creatinine and uric acid].
abstract: OBJECTIVE
  To explore the changes of saliva urea, creatinine (Cr), and uric acid (UA) before and after hemodialysis in patients with end-stage renal disease (ESRD), and to evaluate the clearing effect of Urea, Cr, and UA.
  
  
  METHODS
  Saliva and serum (2 mL) were collected from the dialysis patients. The concentrations of Urea, Cr, and UA in both samples were measured by biochemical analyzer. The concentrations of Urea, Cr, and UA in the saliva and the serum, and their correlation were analyzed. Before and after the hemodialysis, the reduction ratio (RR) of Urea, Cr, and UA in the saliva and the serum was calculated.
  
  
  RESULTS
  In ESRD dialysis patients, the levels of Urea, Cr, and UA in the saliva and the serum were highly correlated (correlation coefficients were 0.979, 0.973, and 0.948, respectively). The concentrations of Urea, Cr, and UA in the saliva and the serum before the dialysis were lower than those after the dialysis, with significant difference (P<0.05). The RR of Urea, Cr, and UA in the saliva and the serum did not differ statistically (P>0.05).
  
  
  CONCLUSIONS
  The clearing effect of salivar Urea, Cr, and UA is similar to that of the serum. Saliva is expected to replace the serum to evaluate hemodialysis efficacy and monitor the renal disease in ESRD patients.
authors.affiliation: Institute of Nephrology, Second Xiangya Hospital, Changsha 410011; Department of Clinical Laboratory, Second Xiangya Hospital, Changsha 410011,China.
authors.forename: Ping
authors.initials: P
authors.lastname: Cheng
authors.forename: Yuncheng
authors.initials: Y
authors.lastname: Xia
authors.forename: Canhui
authors.initials: C
authors.lastname: Peng
authors.forename: Zhifang
authors.initials: Z
authors.lastname: Zhou
mesh_terms: D003404:Creatinine / Q000032:analysis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000628:therapy*; D012463:Saliva / Q000737:chemistry*; D014508:Urea / Q000032:analysis; D014527:Uric Acid / Q000032:analysis
chemical_list: D014527:Uric Acid; D014508:Urea; D003404:Creatinine