title: Development of a consumer product ingredient database for chemical exposure screening and prioritization.
abstract: Consumer products are a primary source of chemical exposures, yet little structured information is available on the chemical ingredients of these products and the concentrations at which ingredients are present. To address this data gap, we created a database of chemicals in consumer products using product Material Safety Data Sheets (MSDSs) publicly provided by a large retailer. The resulting database represents 1797 unique chemicals mapped to 8921 consumer products and a hierarchy of 353 consumer product "use categories" within a total of 15 top-level categories. We examine the utility of this database and discuss ways in which it will support (i) exposure screening and prioritization, (ii) generic or framework formulations for several indoor/consumer product exposure modeling initiatives, (iii) candidate chemical selection for monitoring near field exposure from proximal sources, and (iv) as activity tracers or ubiquitous exposure sources using "chemical space" map analyses. Chemicals present at high concentrations and across multiple consumer products and use categories that hold high exposure potential are identified. Our database is publicly available to serve regulators, retailers, manufacturers, and the public for predictive screening of chemicals in new and existing consumer products on the basis of exposure and risk.
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States. Electronic address: goldsmith.rocky@epa.gov.
authors.forename: M-R
authors.initials: MR
authors.lastname: Goldsmith
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: C M
authors.initials: CM
authors.lastname: Grulke
authors.affiliation: Student Services Contractor at U.S. EPA, RTP, NC, United States.
authors.forename: R D
authors.initials: RD
authors.lastname: Brooks
authors.affiliation: Lockheed-Martin Information Technology, RTP, NC 27711, United States.
authors.forename: T R
authors.initials: TR
authors.lastname: Transue
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States. Electronic address: tan.cecilia@epa.gov.
authors.forename: Y M
authors.initials: YM
authors.lastname: Tan
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States; Oak Ridge Institute for Science and Education Fellow, United States.
authors.forename: A
authors.initials: A
authors.lastname: Frame
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: P P
authors.initials: PP
authors.lastname: Egeghy
authors.affiliation: North Carolina State University, 2200 Hillsborough St., Raleigh, NC 27695, United States.
authors.forename: R
authors.initials: R
authors.lastname: Edwards
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: D T
authors.initials: DT
authors.lastname: Chang
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: R
authors.initials: R
authors.lastname: Tornero-Velez
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States. Electronic address: isaacs.kristin@epa.gov.
authors.forename: K
authors.initials: K
authors.lastname: Isaacs
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States; Oak Ridge Institute for Science and Education Fellow, United States.
authors.forename: A
authors.initials: A
authors.lastname: Wang
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: J
authors.initials: J
authors.lastname: Johnson
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: K
authors.initials: K
authors.lastname: Holm
authors.affiliation: University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, United States.
authors.forename: M
authors.initials: M
authors.lastname: Reich
authors.affiliation: Biosystems and Agricultural Engineering, Michigan State University, E. Lansing, MI 48824, United States.
authors.forename: J
authors.initials: J
authors.lastname: Mitchell
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: D A
authors.initials: DA
authors.lastname: Vallero
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: L
authors.initials: L
authors.lastname: Phillips
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: M
authors.initials: M
authors.lastname: Phillips
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: J F
authors.initials: JF
authors.lastname: Wambaugh
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: R S
authors.initials: RS
authors.lastname: Judson
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: T J
authors.initials: TJ
authors.lastname: Buckley
authors.affiliation: United States Environmental Protection Agency (U.S. EPA), Office of Research and Development, RTP, NC 27711, United States.
authors.forename: C C
authors.initials: CC
authors.lastname: Dary
mesh_terms: D003257:Consumer Product Safety; D003628:Database Management Systems; D004781:Environmental Exposure
keywords: Chemical exposure; Consumer products; Exposure prioritization; Ingredients; Near field exposure; Product formulation