title: Serum melatonin is an alternative index of Parkinson's disease severity.
abstract: The protective potential of melatonin (MLT) in Parkinson's disease (PD) is the subject of considerable controversy. The purpose of the present study was to investigate serum MLT levels in unilateral 6-hydroxydopamine (6-OHDA) lesion rats and patients with PD. Blood samples were collected from rats at 10:00 am and from patients with PD and healthy subjects between 8:00 and 10:00 am. Serum MLT levels were measured using the enzyme-linked immunosorbent assay. Our results revealed that the morning serum MLT levels either in 6-OHDA-induced hemi-parkinsonian rats or patients with PD were significantly higher than that of control group. Our results also demonstrate that serum MLT levels are correlated with severity of PD according to H & Y scale.
authors.affiliation: Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou 350108, China; Department of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Lin
authors.affiliation: Department of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350108, China.
authors.forename: Yuequn
authors.initials: Y
authors.lastname: Du
authors.affiliation: Department of Neurosurgery, Fujian Provincial Hospital, #134 East Street, Fuzhou 350001, China.
authors.forename: Sutao
authors.initials: S
authors.lastname: Yuan
authors.affiliation: Department of Geriatrics, Union Hospital of Fujian Medical University, #29 Xinquan Road, Fuzhou 350001, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Shen
authors.affiliation: Department of Neurology, Fujian Provincial Geriatrics Hospital, #147 Beihuan Road, Fuzhou 350003, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Lin
authors.affiliation: Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Medical University, Fuzhou 350108, China; Department of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350108, China. Electronic address: zhzheng@mail.fjmu.edu.cn.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zheng
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D015415:Biomarkers; D018491:Dopamine Agonists / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008550:Melatonin / Q000097:blood*; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D016627:Oxidopamine / Q000633:toxicity; D010300:Parkinson Disease / Q000097:blood* / Q000175:diagnosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012720:Severity of Illness Index; D013997:Time Factors
chemical_list: D015415:Biomarkers; D018491:Dopamine Agonists; D016627:Oxidopamine; D008550:Melatonin; D001058:Apomorphine
keywords: 6-Hydroxydopamin; 6-OHDA; 6-hydroxydopamine; APO; H & Y; Hoehn and Yahr; Hoehn and Yahr scale; MLT; PD; Parkinson's disease; SEM; Serum melatonin; apomorphine; melatonin; standard error of mean.