title: Influence of deceased donor hemodynamic factors in transplant recipients renal function.
abstract: BACKGROUND
  The incidence of delayed graft function (DGF) and unsatisfactory creatinine clearance (UCC) after renal transplantation is significantly higher in Brazil, when compared with that observed in United States or Europe. Deceased donor (DD) characteristics should directly influence the occurrence of these two outcomes.
  
  
  OBJECTIVE
  This study aim to evaluate the influence of DD characteristics on DGF and UCC incidence in Brazil.
  
  
  METHODS
  DD clinical and laboratory variables were correlated with outcome's incidence.
  
  
  RESULTS
  We evaluated 787 DD whose organs were transplanted in 1298 patients. We noted a high prevalence of vasoactive drugs use (90.2%), hypernatremia (66.6%) and renal dysfunction (34.8%). The incidence of DGF and UCC was 60.6% and 55.2%, respectively. We observed a progressive increase in DGF risk for age groups over 30 years and for cold ischemia time (CIT) greater than 24 hours. DGF risk was two times higher in recipients of donor kidney final serum creatinine (Cr) over than 1.5 mg/dl. Hypertension and CIT over 36 hours was associated with an increasing of 82% and 99% in UCC risk, respectively. Donor age above 40 years was associated with a progressive increase in UCC risk.
  
  
  CONCLUSIONS
  DD age, renal function, hypertension and prolonged CIT were associated with increased risk DGF and UCC.
authors.forename: Ana Paula Maia
authors.initials: AP
authors.lastname: Baptista
authors.forename: Hélio Tedesco
authors.initials: HT
authors.lastname: Silva
authors.forename: José Osmar Medina
authors.initials: JO
authors.lastname: Pestana
mesh_terms: D000293:Adolescent; D000328:Adult; D002102:Cadaver; D002648:Child; D003404:Creatinine / Q000378:metabolism*; D051799:Delayed Graft Function / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D003404:Creatinine