title: The effect of Beta-aminopropionitrile and prednisolone on the prevention of fibrosis in alkali esophageal burns: an experimental study.
abstract: Objective. The aim of this study was to investigate the efficacy of beta-aminopropionitrile (BAPN) and prednisolone on the prevention of esophageal damage and stricture formation after caustic esophageal burn. Method. Twenty-eight rats were divided into four equal groups. In groups 1, 2, and 3, caustic esophageal burns were generated by applying NaOH to the 1.5 cm segment of the abdominal esophagus. Group 4 was for the sham. Normal saline to group 1, BAPN to group 2, and prednisolone to group 3 were administered intraperitoneally as a single daily dose. Results. Treatment with BAPN decreased the stenosis index (SI) and histopathologic damage score (HDS) seen in caustic esophageal burn rats. The SI in group 4 was significantly lower compared with groups 1, 2, and 3. Group 2 had the minimum SI value in corrosive burn groups. The differences related to SI between groups 1, 2, and 3 were not statistically significant. The HDS was significantly lower in group 4 compared with groups 1, 2, and 3. The HDS in group 2 was significantly lower compared with groups 1 and 3. Conclusion. This study demonstrated that BAPN was able to decrease the development of stenosis and tissue damage better than prednisolone.
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Istanbul Bilim University, 34394 Istanbul, Turkey.
authors.forename: Kurtulus
authors.initials: K
authors.lastname: Aciksari
authors.affiliation: Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Hakan Teoman
authors.initials: HT
authors.lastname: Yanar
authors.affiliation: Department of General Surgery, MoH Bagcilar Research and Training Hospital, 34200 Istanbul, Turkey.
authors.forename: Gulcin
authors.initials: G
authors.lastname: Hepgul
authors.affiliation: Department of Emergency Medicine, MoH Bakirkoy Dr. Sadi Konuk Research and Training Hospital, 34147 Istanbul, Turkey.
authors.forename: Dogac Niyazi
authors.initials: DN
authors.lastname: Ozucelik
authors.affiliation: Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Yanar
authors.affiliation: Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Orhan
authors.initials: O
authors.lastname: Agcaoglu
authors.affiliation: Department of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University, 34098 Istanbul, Turkey.
authors.forename: Mediha
authors.initials: M
authors.lastname: Eser
authors.affiliation: Department of Histology and Embryology, Cerrahpasa Faculty of Medicine, Istanbul University, 34098 Istanbul, Turkey.
authors.forename: Gamze
authors.initials: G
authors.lastname: Tanriverdi
authors.affiliation: Department of Emergency Medicine, MoH Istanbul Research and Training Hospital, 34098 Istanbul, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Topacoglu
authors.affiliation: Department of Emergency Medicine, MoH Okmeydani Research and Training Hospital, 34384 Istanbul, Turkey.
authors.forename: Baris Murat
authors.initials: BM
authors.lastname: Ayvaci
authors.affiliation: Department of Emergency, MoH Avcilar State Hospital, 34320 Istanbul, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Dogan
authors.affiliation: Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Kayihan
authors.initials: K
authors.lastname: Gunay
authors.affiliation: Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, 34093 Istanbul, Turkey.
authors.forename: Cemalettin
authors.initials: C
authors.lastname: Ertekin
authors.affiliation: Department of Emergency Medicine, MoH Kartal Lutfi Kırdar Research and Training Hospital, 34880 Istanbul, Turkey.
authors.forename: Ferudun
authors.initials: F
authors.lastname: Celikmen