title: Correlations between tumor stroma characters and dynamic enhanced MDCT findings in nodular pulmonary adenocarcinoma.
abstract: OBJECTIVE
  This study aimed to evaluate correlations between tumor stroma characters and dynamic contrast-enhanced computed tomographic (CT) findings in nodular pulmonary adenocarcinoma.
  
  
  METHODS
  Thirty-three patients with nodular pulmonary adenocarcinoma underwent dynamic contrast-enhancement CT scan before surgery. CT findings include wash-in, wash-out, and distribution of enhancement. The proportion of invasive and noninvasive stroma in tumor was calculated.
  
  
  RESULTS
  Invasive and noninvasive stroma proportion in tumor was correlated positively with wash-in and wash-out enhancement, respectively.
  
  
  CONCLUSIONS
  Tumor stroma proliferation may explain the pathologic basis of CT dynamic enhancement and be a useful prognostic factor of pulmonary adenocarcinoma.
authors.affiliation: From the *Department of Radiology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian Province; and †Department of Radiology, The 5th Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guang Dong Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Jin-an
authors.initials: JA
authors.lastname: Wang
authors.forename: Kun-ru
authors.initials: KR
authors.lastname: Liang
authors.forename: Ming-zhu
authors.initials: MZ
authors.lastname: Liang
authors.forename: Xue-guo
authors.initials: XG
authors.lastname: Liu
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000473:pathology; D000328:Adult; D000368:Aged; D003287:Contrast Media; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007472:Iohexol / Q000031:analogs & derivatives; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography / Q000379:methods*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging* / Q000473:pathology
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide