title: [Characteristics of antiischemic and nootropic properties of ademol in a rat model of acute brain ischemia].
abstract: In experiments with the rat model of acute disorder of encephalic circulation (bilateral carotid occlusion) it was found that introduction of derivate of adamantan 1-adamantiloxy-3-morfolino-2 propanol (under conventional name ademol) in the dose 2 mg/kg intraabdominal in treatment regimen (in an hour after reconstruction of insult and further 1 time every 24 hours during 21 days) was accompanied by a recovery of mnemotropic properties and is more effective than cytikolin, resulting in a decreased lethality and neurological deficiency in acute and recovery periods of insults. The data received proved the usefulness of development of ademol based cerebroprotective remedy.
authors.forename: O A
authors.initials: OA
authors.lastname: Khodakivs'kyĭ
mesh_terms: D000208:Acute Disease; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001581:Benzothiadiazines / Q000494:pharmacology*; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D002339:Carotid Arteries / Q000601:surgery; D054059:Coronary Occlusion / Q000150:complications; D007274:Injections, Intraperitoneal; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D016019:Survival Analysis
chemical_list: D001581:Benzothiadiazines; D018696:Neuroprotective Agents; D018697:Nootropic Agents; C511328:flumethiazide