title: [Response to neoadjuvant chemotherapy in breast cancer as assessed by subtype].
abstract: The aim of this study was to investigate the responses to neoadjuvant chemotherapy (NAC) in breast cancer according to subtype. The study included 69 women who received NAC at our hospital between January 2004 and January 2013. Complete response( CR) was achieved in 14 patients( 20.3%) and partial response( PR) was achieved in 37 patients (53.6%).CR and PR rates according to subtype were as follows: 0% and 57.1% for the luminal type, 0% and 66.7% for the luminal-human epidermal growth factor receptor (HER)-2 type, 16% and 56% for the triple negative type, and 58.8% and 41.2% for the HER2 type, respectively. The CR rate was the highest among patients with HER2-type breast cancer. Trastuzumab was additionally administered to 12 patients with HER2-type breast cancer, and the CR rate among these patients was significantly higher after trastuzumab treatment( 75%).Thus, it is important to select a treatment strategy for breast cancer on the basis of the subtype diagnosed.
authors.affiliation: Dept. of Surgery, Hyogo Prefectural Nishinomiya Hospital.
authors.forename: Muneharu
authors.initials: M
authors.lastname: Konishi
authors.forename: Junya
authors.initials: J
authors.lastname: Minohata
authors.forename: Sachiko
authors.initials: S
authors.lastname: Mizumoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kubo
authors.forename: Tomoki
authors.initials: T
authors.lastname: Hata
authors.forename: Kei
authors.initials: K
authors.lastname: Asukai
authors.forename: Kozo
authors.initials: K
authors.lastname: Noguchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takiuchi
authors.forename: Rie
authors.initials: R
authors.lastname: Hamano
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Masaki
authors.initials: M
authors.lastname: Kashiwazaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Miki
authors.forename: Masaki
authors.initials: M
authors.lastname: Tsujie
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yano
mesh_terms: D000328:Adult; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D000068878:Trastuzumab; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D018719:Erb-b2 Receptor Tyrosine Kinases; D000068878:Trastuzumab