title: Primary angiosarcoma of bone. A case report.
abstract: BACKGROUND
  Primary malignant vascular tumors of bone are very rare accounting for less than 1% of primary bone malignancies. They are characterized by unknown etiology, variable biologic behavior and histological appearance. Angiosarcoma is an aggressive malignant vascular tumor derived from mesenchymal cells with endothelial differentiation.
  
  
  METHODS
  We present a rare case of angiosarcoma of bone in a 47-year-old male operated for a lumbar disk herniation. During his transportation from the operation theater, a pathological intertrochanteric fracture of the right hip occured. The magnetic resonance imaging (MRI) revealed a bone lytic lesion located into the great trochanter of the right femur. Open surgical biopsy of the lesion was performed and the histological examination showed primary angiosarcoma of bone. The treatment included radiotherapy (300 cGy per fraction in 13 days) followed by excision of the proximal femur and custom made total hip arthroplasty. The diagnosis was confirmed on the surgical specimen.
authors.affiliation: Department of Pathology, Cancer Hospital of Thessaloniki "Theagenio"
authors.forename: A
authors.initials: A
authors.lastname: Baliaka
authors.affiliation: Department of Pathology, Cancer Hospital of Thessaloniki "Theagenio"
authors.forename: Gc
authors.initials: G
authors.lastname: Balis
authors.affiliation: Department of Pathology, Cancer Hospital of Thessaloniki "Theagenio"
authors.forename: E
authors.initials: E
authors.lastname: Michalopoulou-Manoloutsiou
authors.affiliation: Department of Pathology, General Hospital of Thessaloniki "G.Gennimatas", Thessaloniki, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Papanikolaou
authors.affiliation: Department of Pathology, Cancer Hospital of Thessaloniki "Theagenio"
authors.forename: A
authors.initials: A
authors.lastname: Nikolaidou
keywords: Primary angiosarcoma; bone; vascular tumor