title: Primary mucosal sinonasal melanoma-Case report and review of the literature. The role of complex treatment-surgery and adjuvant radiotherapy.
abstract: OBJECTIVE
  The place of adjuvant radiotherapy in the treatment of sinonasal melanoma.
  
  
  BACKGROUND
  Sinonasal mucosal melanoma is a rare disease with poor prognosis and requires a complex treatment. Elective neck dissection in patients with N0 and adjuvant radiotherapy has been a source of controversy. High late regional recurrence rates rise questions about elective irradiation of the neck nodes in patients with N0 stage disease.
  
  
  METHODS
  We present our two years' follow up in a case of locally advanced sinonasal melanoma and literature review of the treatment options for mucosal melanoma.
  
  
  RESULTS
  In locally advanced sinonasal melanoma treated with surgical resection, postoperative radiotherapy and chemotherapy we had local tumor control. Two years later, a regional contralateral recurrence without distant metastasis occurred.
  
  
  CONCLUSIONS
  Literature data for frequent neck lymph nodes recurrences justify elective neck dissection. Postoperative elective neck radiotherapy for patients with locally advanced sinonasal melanoma and clinically N0 appears to decrease the rate of late regional recurrences.
authors.affiliation: Radiotherapy Department, Oncology Hospital, Medical University - Varna, Varna, Bulgaria.
authors.forename: Lena
authors.initials: L
authors.lastname: Marinova
authors.affiliation: Radiotherapy Department, Oncology Hospital, Medical University - Varna, Varna, Bulgaria.
authors.forename: Kaloyan
authors.initials: K
authors.lastname: Yordanov
authors.affiliation: Oto-rhyno-laryngology Department, University Hospital "Sveta Marina", Medical University - Varna, Varna, Bulgaria.
authors.forename: Nikolay
authors.initials: N
authors.lastname: Sapundgiev
keywords: Complex treatment; Mucosal melanoma; Radiotherapy; Sinonasal melanoma; Surgery