title: Meta-analysis of the MDM2 T309G polymorphism and gastric cancer risk.
abstract: BACKGROUND
  Mdm2 binds to the amino-terminus of p53 to induce its degradation and a single nucleotide polymorphism in the MDM2 promoter region (T309G) has been reported to increase the risk of several carcinomas, such as gastric cancer. However, the results of published studies to analyze the association between MDM2 T309G and gastric cancer havve often conflicted.
  
  
  METHODS
  To better illustrate the filiation between MDM2 T309G and gastric cancer, we performed a meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the relationship. The pooled ORs were performed for 4 models, additive, recessive, co-dominant model, and dominant.
  
  
  RESULTS
  Nine published case-control studies including 3,225 gastric cancer cases and 4,118 controls were identified. The MDM2 T309G polymorphism was associated with a significantly increased risk of gastric cancer risk when all studies were pooled into the meta-analysis (GG versus TT, OR=1.57; 95%CI=1.57-2.12; p=0.003) and GG versus GT/TT, OR=1.52; 95%CI=1.217-1.90; p<0.001). Furthermore, Egger<s test did not show any evidence of publication bias (P = 0.608 for GG versus TT).
  
  
  CONCLUSIONS
  Our results suggest that the MDM2 T309G polymorphism is indeed associated with a significantly increased risk of gastric cancer.
authors.affiliation: Department of General Surgery, The Fourth Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China E-mail : luokaiyuanyunnan@163.com.
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.forename: Zhong-Yu
authors.initials: ZY
authors.lastname: Duan
authors.forename: Yun-Hua
authors.initials: YH
authors.lastname: Zhong
authors.forename: Na
authors.initials: N
authors.lastname: Lei
authors.forename: Yu-Qing
authors.initials: YQ
authors.lastname: Yang
authors.forename: Kai-Yuan
authors.initials: KY
authors.lastname: Luo
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000209:etiology*
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2