title: [Research progress of heme oxygenase 1 in bone tissue engineering].
abstract: OBJECTIVE
  To review the latest research progress of heme oxygenase 1 (HO-1), to thoroughly understand different functions of HO-1 and its influence on osteogenesis and angiogenesis of stem cells, and to analyze HO-1 application in bone tissue engineering.
  
  
  METHODS
  Domestic and international literature on HO-1 in recent years was extensively reviewed and analyzed.
  
  
  RESULTS
  The activity of HO-1 and its enzymatic products not only have the properties of anti-inflammatory, anti-apoptosis, and cytoprotection, but also can promote angiogenesis combined with other growth factors and protect the vessel which already exist. Moreover, HO-1 has an effect on the proliferation, paracrine signaling, osteoblastic differentiation, and anti-apoptosis of stem cells.
  
  
  CONCLUSIONS
  HO-1 can be used as a multi-function growth factor in bone tissue engineering, but more investigation should emphasis on synergistic effect of each function so as to improve bone repair.
authors.affiliation: Graduate Department of Tianjin Medical University, Tianjin 300070, PR China.
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Bone and Soft Tissue Tumor, Tianjin Hospital, PR China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Graduate Department of Tianjin Medical University, Tianjin 300070, PR China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Fang
authors.affiliation: Graduate Department of Tianjin Medical University, Tianjin 300070, PR China.
authors.forename: Rongxin
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Graduate Department of Tianjin Medical University, Tianjin 300070, PR China.
authors.forename: Han
authors.initials: H
authors.lastname: Wang
authors.affiliation: Graduate Department of Tianjin Medical University, Tianjin 300070, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: He
authors.affiliation: Graduate Department of Tianjin Medical University, Tianjin 300070, PR China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Yuan
mesh_terms: D000818:Animals; D017209:Apoptosis; D001664:Biliverdine / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002248:Carbon Monoxide / Q000378:metabolism*; D002454:Cell Differentiation; D002478:Cells, Cultured; D051547:Heme Oxygenase-1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D018919:Neovascularization, Physiologic; D010012:Osteogenesis / Q000187:drug effects*; D023822:Tissue Engineering; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D042461:Vascular Endothelial Growth Factor A; D002248:Carbon Monoxide; D051547:Heme Oxygenase-1; D001664:Biliverdine