title: Increased bile resistance in Salmonella enterica mutants lacking Prc periplasmic protease.
abstract: Prc is a periplasmic protease involved in processing of penicillin-binding protein 3 (PBP3). Lack of Prc suppresses bile sensitivity in Dam-, Wec-, PhoP-, DamX-, and SeqA- mutants of Salmonella enterica, and increases bile resistance in the wild type. Changes in the activity of penicillin binding proteins PBP3, PBP4, PBP5/6 and PBP7 are detected in a Prc- background, suggesting that peptidoglycan remodeling might contribute to bile resistance.
authors.affiliation: Department of Genetics, School of Biology, University of Sevilla, Sevilla, Spain.
authors.forename: Sara B
authors.initials: SB
authors.lastname: Hernández
authors.affiliation: Center of Molecular Biology Severo Ochoa, CSIC-Autonomous University of Madrid, Cantoblanco, Spain.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Ayala
authors.affiliation: National Center of Biotechnology (CNB)-CSIC, Madrid, Spain.
authors.forename: Gadea
authors.initials: G
authors.lastname: Rico-Pérez
authors.affiliation: National Center of Biotechnology (CNB)-CSIC, Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: García-del Portillo
authors.affiliation: Department of Genetics, School of Biology, University of Sevilla, Sevilla, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Casadesús
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001646:Bile / Q000737:chemistry; D001647:Bile Acids and Salts / Q000494:pharmacology*; D006801:Humans; D009154:Mutation; D046915:Penicillin-Binding Proteins / Q000235:genetics / Q000378:metabolism; D010447:Peptide Hydrolases / Q000172:deficiency* / Q000235:genetics; D019897:Periplasm / Q000201:enzymology* / Q000235:genetics; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001647:Bile Acids and Salts; D046915:Penicillin-Binding Proteins; D010447:Peptide Hydrolases