title: Interbirth interval and history of previous preeclampsia: a case-control study among multiparous women.
abstract: BACKGROUND
  Preeclampsia is a disorder with a reported incidence of 2%-8% among all pregnancies, accounting for more than 50,000 deaths worldwide each year. In low- and middle- income countries maternal/perinatal morbidity and mortality associated with preeclampsia are high due to the lack of proper prenatal and hospital care and limited access to neonatal intensive care. The objectives of our study were to determine the association of long interbirth interval (IBI) and preeclampsia and to investigate the interactions between long IBI and other risk factors among multiparous women in Yerevan, Armenia.
  
  
  METHODS
  We conducted a hospital-based case-control study among 36 multiparous women with preeclampsia (cases) and 148 without preeclampsia (controls) during their last pregnancy, selected from the two largest maternity hospitals in Armenia. The data were collected through telephone-based structured interviews and analyzed using STATA software. The study applied univariate and multivariate logistic regression analyses.
  
  
  RESULTS
  The study found a significant interaction between IBI and previous history of preeclampsia. Among women without a history of previous preeclampsia, the odds of having preeclampsia among women with long IBI (greater than or equal to five years) was 6.88 time higher compared to those with short IBI (CI: 1.75-27.05; p = 0.006) after adjusting for confounders; among women with a history of previous preeclampsia the odds ratio was 0.60 (CI: 0.07-4.99; p = 0.638). The final fitted model for preeclampsia among multiparous women who had planned their pregnancies included IBI, time to pregnancy, Body Mass Index, method of contraception and household monthly income.
  
  
  CONCLUSIONS
  Long IBI appeared to be a strong risk factor for preeclampsia development only among women without a history of previous preeclampsia. This finding may contribute to a new approach in understanding the etiology of preeclampsia and may be useful for developing further recommendations for this particular subgroup of women that are at higher risk for preeclampsia development in subsequent pregnancies.
authors.affiliation: American University of Armenia, College of Health Sciences, Baghramyan 40, Yerevan, Armenia. aharutyunyan@aua.am.
authors.forename: Arusyak
authors.initials: A
authors.lastname: Harutyunyan
authors.forename: Haroutune
authors.initials: H
authors.lastname: Armenian
authors.forename: Varduhi
authors.initials: V
authors.lastname: Petrosyan
mesh_terms: D000328:Adult; D001136:Armenia / Q000453:epidemiology; D001721:Birth Intervals; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010298:Parity; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D012008:Recurrence; D017584:Reproductive History; D012307:Risk Factors; D061685:Time-to-Pregnancy; D055815:Young Adult