title: Luteolin inhibits mast cell-mediated allergic inflammation.
abstract: Mast cells are ubiquitous in the body and multifunctional immune cells; they are known to be primary responders in allergic reactions, orchestrating strong responses to minute amounts of allergens. Mature mast cells perform important beneficial roles in host defense, both in IgE-dependent immune responses to certain parasites and in natural immunity to bacterial infection. In IgE-associated biological responses, the crosslinking of Fc&#949;RI-bound IgE with multivalent antigens initiate the activation of mast cells by promoting aggregation of FceRI. This cross-linking receptor-bound IgE by multivalent Ag initiates a cascade of intracellular reactions leading to mediator release such as proinflammatory mediators, chemokines and cytokines. Luteolin belongs to a flavone group of compounds called flavonoids, it has anti-oxidant properties, inhibits some cancer cell proliferation and exerts a regulatory effect on mast cell-mediated inflammatory diseases and allergy. Here we report the impact of luteolin on mast cell activation.
authors.affiliation: Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Macedonia, Greece.
authors.forename: S K
authors.initials: SK
authors.lastname: Kritas
authors.affiliation: Department of Dermatology, University of Rome Tor Vergata, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Saggini
authors.affiliation: Dental School, University of Chieti-Pescara, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Varvara
authors.affiliation: Dental School, University of Chieti-Pescara, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Murmura
authors.affiliation: Orthopedic Division, University of Perugia, Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.affiliation: Orthopedic Division, University of Perugia, Perugia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.affiliation: Immunology Division, Medical School, University of Chieti-Pescara, Chieti, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Toniato
authors.affiliation: Orthopedic Division, University of Chieti-Pescara, Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pantalone
authors.affiliation: Department of Neurosciences and Imaging, Faculty of Medicine and Surgery, G. d'Annunzio University Chieti-Pescara, Chieti, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Neri
authors.affiliation: Department of Parasitology, School of Veterinary Medicine, University of Thessaloniki, Macedonia, Greece.
authors.forename: S
authors.initials: S
authors.lastname: Frydas
authors.affiliation: Gynecology Clinic, Pescara Hospital, Pescara, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rosati
authors.affiliation: Nicolas Foundation, Onlus, Arezzo, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tei
authors.affiliation: Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Speziali
authors.affiliation: Department of Neurosciences and Imaging, Faculty of Medicine and Surgery, G. d'Annunzio University Chieti-Pescara, Chieti, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Saggini
authors.affiliation: Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Pandolfi
authors.affiliation: Nicolas Foundation, Onlus, Arezzo, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cerulli
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Biochemistry and Internal Medicine Tufts University School of Medicine, Tufts-New England Medi-cal Center, Boston, MA, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Theoharides
authors.affiliation: Immunology Division, Medical School, University of Chieti-Pescara, Chieti, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Conti
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D047311:Luteolin / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects* / Q000502:physiology
chemical_list: D018926:Anti-Allergic Agents; D000893:Anti-Inflammatory Agents; D007073:Immunoglobulin E; D047311:Luteolin