title: Electrochemical analysis in a liposome suspension using lapachol as a hydrophobic electro active species.
abstract: This study demonstrated that the electro-chemical analysis of hydrophobic quinones can be performed in liposome suspension systems. We prepared and analyzed liposome suspensions containing lapachol, which is a quinone-based anti-tumor activity compound. In this suspension system, a simple one redox couple of lapachol is observed. These results are quite different from those obtained in organic solvents. In addition, the pH dependence of redox behaviors of lapachol could be observed in multilamellar vesicle (MLV) suspension system. This MLV suspension system method may approximate the electrochemical behavior of hydrophobic compounds in aqueous conditions. A benefit of this liposome suspension system for electrochemical analysis is that it enables to observe water-insoluble compounds without using organic solvents.
authors.affiliation: Department of Pharmacy, Kinjo Gakuin University.
authors.forename: Noriko
authors.initials: N
authors.lastname: Okumura
authors.forename: Shiori
authors.initials: S
authors.lastname: Wakamatsu
authors.forename: Bunji
authors.initials: B
authors.lastname: Uno
mesh_terms: D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry*; D009285:Naphthoquinones / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013535:Suspensions / Q000737:chemistry*
chemical_list: D008081:Liposomes; D009285:Naphthoquinones; D011809:Quinones; D012997:Solvents; D013535:Suspensions; C008252:lapachol