title: Inhibition of SATB1 by shRNA suppresses the proliferation of cutaneous malignant melanoma.
abstract: Overexpression of special AT-rich sequence binding protein 1 (SATB1), a global genome organizer, as a predictor of poor prognosis in cutaneous malignant melanoma (CMM) attracted great interest in previous research. In this article, upregulated SATB1 was observed in three melanoma cell lines and in eight CMM tissues. After downregulating SATB1 by RNAi, proliferation of A375 was suppressed in vitro and in vivo. In summary, the proliferation of CMM could be related closely to the SATB1 gene. Interference of this gene may be a promising method for CMM therapy.
authors.affiliation: 1 Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College , Nanjing, China .
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Cheng
authors.forename: Runzhi
authors.initials: R
authors.lastname: He
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Jianfang
authors.initials: J
authors.lastname: Sun
mesh_terms: D000818:Animals; D048708:Cell Growth Processes / Q000235:genetics; D045744:Cell Line, Tumor; D015536:Down-Regulation; D005260:Female; D020868:Gene Silencing; D006801:Humans; D036961:Matrix Attachment Region Binding Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics; D008545:Melanoma / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008819:Mice, Nude; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000235:genetics; D011897:Random Allocation; D012878:Skin Neoplasms; D014162:Transfection; D015854:Up-Regulation; D023041:Xenograft Model Antitumor Assays; D000096142:Cutaneous Malignant Melanoma
chemical_list: D036961:Matrix Attachment Region Binding Proteins; D034741:RNA, Small Interfering; C076189:SATB1 protein, human