title: Homocysteine is associated with plasma high-sensitivity cardiac troponin T levels in a community-dwelling population.
abstract: OBJECTIVE
  Homocysteine (HCY) is associated with an increased risk for cardiovascular disease, possibly leading to myocardial damage. Cardiac troponin T (TnT), a marker of cardiomyocyte injury, can be detected by high-sensitivity TnT (hsTnT) assay. The current study investigated the relationship between plasma HCY and hsTnT levels in a community-based population.
  
  
  METHODS
  We related plasma levels of hsTnT to HCY levels in 1,497 participants (mean age, 62.4 years; 629 men, 868 women) from a community-based population in Beijing, People's Republic of China.
  
  
  RESULTS
  In multiple logistic regression models, serum HCY was associated with a higher likelihood of detectable hsTnT (odds ratio 1.5; 95% confidence interval 1.07-2.10; P=0.018). A subsequent subgroup analysis found that in subjects aged 65 years and older, the association between hsTnT levels and HCY levels was strengthened. The association between hsTnT and HCY was not present in the younger subgroup (<65 years old).
  
  
  CONCLUSIONS
  Levels of serum HCY are associated with hsTnT levels in the elderly, indicating a relationship between HCY and subclinical myocardial damage.
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Ruihua
authors.initials: R
authors.lastname: Cao
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Yongyi
authors.initials: Y
authors.lastname: Bai
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Ruyi
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D009202:Cardiomyopathies / Q000097:blood / Q000503:physiopathology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006710:Homocysteine / Q000097:blood* / Q000502:physiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020107:Troponin T / Q000097:blood* / Q000502:physiology
chemical_list: D015415:Biomarkers; D020107:Troponin T; D006710:Homocysteine; D002097:C-Reactive Protein
keywords: epidemiology; markers; myocardial damage; relationship; subclinical