title: Designing a simple organic salt-based supramolecular topical gel capable of displaying in vivo self-delivery application.
abstract: The supramolecular synthon approach has been exploited to design simple salt-based supramolecular gelators derived from a non-steroidal anti-inflammatory drug (NSAID) - naproxen; one such biocompatible anti-inflammatory gelator salt was converted into a topical gel that showed excellent in vivo self-delivery application in treating imiquimod (IMQ)-induced skin inflammation in mice.
authors.affiliation: Department of Organic Chemistry, Indian Association for the Cultivation of Science (IACS), 2A & 2B Raja S. C. Mullick Road, Jadavpur, Kolkata - 700032, West Bengal, India.
authors.forename: Joydeb
authors.initials: J
authors.lastname: Majumder
authors.forename: Jolly
authors.initials: J
authors.lastname: Deb
authors.forename: Mahua Rani
authors.initials: MR
authors.lastname: Das
authors.forename: Siddhartha Sankar
authors.initials: SS
authors.lastname: Jana
authors.forename: Parthasarathi
authors.initials: P
authors.lastname: Dastidar
mesh_terms: D000287:Administration, Topical; D000634:Aminoquinolines / Q000009:adverse effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D005782:Gels; D000077271:Imiquimod; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D009288:Naproxen / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use; D010455:Peptides / Q000737:chemistry; D012492:Salts / Q000737:chemistry*
chemical_list: D000634:Aminoquinolines; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005782:Gels; D010455:Peptides; D012492:Salts; D009288:Naproxen; D000077271:Imiquimod