title: Touch imprint cytology of core needle biopsy specimens for the breast and quick stain procedure for immediate diagnosis.
abstract: OBJECTIVE
  To investigate the validity and reproducibility of touch imprint cytology (TIC) of core needle biopsies (CNBs) in the assessment of conspicuous breast findings.
  
  
  METHODS
  One hundred and fifty-eight conspicuous breast findings were assessed by CNB during a two-year period in this prospective study. TIC of the CNBs was used for cytological analysis. The performance of this technique was evaluated by comparing the results with the histology of the CNB, and in cases of a subsequent surgery, with the final histology. In addition, inter-observer reproducibility was analyzed.
  
  
  RESULTS
  The inter-observer variability was very high (kappa-value of 0.8508; excluding inadequate imprints, 0.9502). Inadequate cellularity for cytological analysis was found in 11.4% (18/158) of findings. Compared with CNB histology, the sensitivity, specificity, positive predictive value, negative predictive value and overall accuracy of TIC was 99%, 100%, 100%, 94%, and 99%, respectively.
  
  
  CONCLUSIONS
  TIC of CNB specimens of the breast may be a valid option for providing a diagnosis without delay for a histological procedure, assuming good quality of the specimen.
authors.affiliation: Department of Obstetrics and Gynaecology University Medical Centre Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. sven.kehl@gmail.com.
authors.forename: Sven
authors.initials: S
authors.lastname: Kehl
authors.forename: Christina
authors.initials: C
authors.lastname: Mechler
authors.forename: Susanne
authors.initials: S
authors.lastname: Menton
authors.forename: Christel
authors.initials: C
authors.lastname: Weiss
authors.forename: Sabine
authors.initials: S
authors.lastname: Wasgindt
authors.forename: Marc
authors.initials: M
authors.lastname: Sütterlin
authors.forename: Marcus
authors.initials: M
authors.lastname: Trunk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D062005:Biopsy, Large-Core Needle / Q000379:methods*; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000145:classification* / Q000175:diagnosis*; D016022:Case-Control Studies; D004396:Coloring Agents; D003581:Cytodiagnosis; D003584:Cytological Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D004396:Coloring Agents
keywords: Touch imprint; breast cancer; core nedle biopsy; cytology; quick stain