title: [The effect of two methods guided fluid therapy to the patient undergoing open gastrointestinal surgery].
abstract: OBJECTIVE
  To investigate the effect of central venous blood oxygen saturation (ScvO2) and venous-arterial PCO2 (P(cv-a)CO2) guided fluid therapy on tissue perfusion, gastrointestinal function recovering and outcome of the patients who undergoing open gastrointestinal surgery.
  
  
  METHODS
  Forty patients undergoing open gastrointestinal surgery were randomly divided into 2 groups (n = 20 each): ScvO2 guided fluid therapy (group S) and P(cv-a) CO2 guided fluid therapy (group P). All the patients were infused 10 ml/kg lactated Ringer's (LR) solution before anesthesia induction, they were all also given a continuous lactated Ringer's (LR) solution's infusion at the speed of 2 ml·kg(-1)·h(-1) during the operation. While, 6%HES 130/0.4 (free flex 6%HES 130/0.4, Fresenius Kabi) infusion was different between the 2 groups, when the patients of group S's central venous blood oxygen saturation < 75% or venous-arterial PCO2 in the patients of P group ≥6 mm Hg, then infused 6%HES 130/0.4. Arterial and central venous blood gas analyses were performed every 20 minutes after skin incision, measure the venous and arterial lactate value, and record the anal exhaust time after surgery, postoperative complications and mortality in 28 days.
  
  
  RESULTS
  Compared with group S, the arterial lactate value in T4 (after operation began 80 min) were significantly decreased in group P (P = 0.013), and venous lactate value in T5 (after operation began 100 min) were also lower (P = 0.044), other lactate value were not different (P > 0.05) . The anal exhaust time was not different between the two groups (P = 0.673). All the patients were survival, and there were no obvious postoperative complications.
  
  
  CONCLUSIONS
  Compared to group S, there was a transient improvement in tissue perfusion in group P, but there were no difference in complications and mortality.
authors.affiliation: Department of Anesthesiology, First Affiliate Hospital of Zhejiang University, Hangzhou 310003, Medical Center of Ningbo Li Huili Hospital, Ningbo 315040, China.
authors.forename: Zheng-yuan
authors.initials: ZY
authors.lastname: Liu
authors.forename: Guo-hao
authors.initials: GH
authors.lastname: Xie
authors.forename: Shui-jing
authors.initials: SJ
authors.lastname: Wu
authors.forename: Zhi-hao
authors.initials: ZH
authors.lastname: Pan
authors.affiliation: Email: xinagming_fang@163.com.
authors.forename: Xiang-ming
authors.initials: XM
authors.lastname: Fang
mesh_terms: D000368:Aged; D001784:Blood Gas Analysis; D013505:Digestive System Surgical Procedures; D005260:Female; D005440:Fluid Therapy / Q000379:methods*; D006801:Humans; D007813:Laparotomy; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period