title: Intravascular photoacoustics for image-guidance and temperature monitoring during plasmonic photothermal therapy of atherosclerotic plaques: a feasibility study.
abstract: Recently, combined intravascular ultrasound and photoacoustic (IVUS/IVPA) imaging has been demonstrated as a novel imaging modality capable of visualizing both morphology (via IVUS) and cellular/molecular composition (via IVPA) of atherosclerotic plaques, using both endogenous tissue absorbers and exogenous contrast agents. Plasmonic gold nanoparticles were previously utilized as IVPA contrast agents which co-localize with atherosclerotic plaques, particularly phagocytically active macrophages. The present work demonstrates the use of IVUS/IVPA imaging as a tool for localized temperature monitoring during laser heating. The temperature dependent change in IVPA signal intensity of silica-coated gold nanorod contrast agents absorbing within the near-infrared optical wavelength range is evaluated and shown to have a linear relationship, with a slope greater than that of endogenous tissue. A continuous wave laser was subsequently incorporated into the IVUS/IVPA integrated catheter and utilized to selectively heat the nanoparticles with simultaneous IVPA temperature monitoring. IVUS/IVPA, therefore, provides a platform for detection and temperature monitoring of atherosclerotic plaques through the selective heating of plasmonic gold nanoparticle contrast agents.
authors.affiliation: 1. Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA 78712;
authors.forename: Doug
authors.initials: D
authors.lastname: Yeager
authors.affiliation: 1. Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA 78712; ; 2. Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX, USA 78712;
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Chen
authors.affiliation: 3. Department of Pathology, University of Alabama Birmingham, Birmingham, AL, USA 35249.
authors.forename: Silvio
authors.initials: S
authors.lastname: Litovsky
authors.affiliation: 1. Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA 78712; ; 2. Department of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX, USA 78712;
authors.forename: Stanislav
authors.initials: S
authors.lastname: Emelianov
mesh_terms: D000368:Aged; D000818:Animals; D050197:Atherosclerosis / Q000175:diagnosis / Q000188:drug therapy*; D002478:Cells, Cultured; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000188:drug therapy*; D003331:Coronary Vessels / Q000473:pathology; D005240:Feasibility Studies; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D051379:Mice; D043942:Nanotubes / Q000737:chemistry; D061088:Photoacoustic Techniques / Q000379:methods*; D010778:Photochemotherapy / Q000379:methods*; D058226:Plaque, Atherosclerotic / Q000188:drug therapy* / Q000473:pathology*; D020349:Surface Plasmon Resonance; D062125:Thermometry / Q000379:methods*
chemical_list: D006046:Gold
keywords: atherosclerosis; gold nanorods; intravascular.; photoacoustic; photothermal; temperature monitoring