title: Fatal metastatic cutaneous squamous cell carcinoma evolving from a localized verrucous epidermal nevus.
abstract: A malignant transformation is known to occur in many nevi such as a sebaceous nevus or a basal cell nevus, but a verrucous epidermal nevus has only rarely been associated with neoplastic changes. Keratoacanthoma, multifocal papillary apocrine adenoma, multiple malignant eccrine poroma, basal cell carcinoma and cutaneous squamous cell carcinoma (CSCC) have all been reported to develop from a verrucous epidermal nevus. CSCC has also been reported to arise from other nevoid lesions like a nevus comedonicus, porokeratosis, a sebaceous nevus, an oral sponge nevus and an ichthyosiform nevus with CHILD syndrome. Here we report a case of progressive poorly differentiated CSCC arising from a localized verrucous epidermal nevus, which caused both spinal cord and brain metastasis.
authors.affiliation: Rumailah Hospital, Doha, Qatar.
authors.forename: Hassan
authors.initials: H
authors.lastname: Riad
authors.affiliation: Rumailah Hospital, Doha, Qatar.
authors.forename: Khaled
authors.initials: K
authors.lastname: Mansour
authors.affiliation: Rumailah Hospital, Doha, Qatar.
authors.forename: Hussein Al
authors.initials: HA
authors.lastname: Sada
authors.affiliation: Rumailah Hospital, Doha, Qatar.
authors.forename: Khalifa Al
authors.initials: KA
authors.lastname: Naama
authors.affiliation: Rumailah Hospital, Doha, Qatar.
authors.forename: Amal Al
authors.initials: AA
authors.lastname: Shaigy
authors.affiliation: Rumailah Hospital, Doha, Qatar.
authors.forename: Khairunnisa
authors.initials: K
authors.lastname: Hussain
keywords: Cutaneous squamous cell carcinoma; Epidermal nevus; Fatal metastatic cutaneous squamous cell carcinoma; Localized verrucous epidermal nevus; Metastasis