title: Antidiabetic and Antioxidant Activity of Scoparia dulcis Linn.
abstract: The hypoglycaemic activity of methanol extract of Scoparia dulcis was performed on both in vitro and in vivo models along with determination of total extractable polyphenol. Methanol extract of Scoparia dulcis contains 4.9% and water extract contains 3.2% of total extractable polyphenol. The antioxidant activity showed very promising result in both the tested methods that is 2,2-diphenyl-1-picrylhydrazyl and ferric ion reducing capacity. The antioxidant activity is directly correlated to the antidiabetic potential of drug. The two enzymes (amylase and glycosidase) found in intestine are responsible for the increasing postprandial glucose in body. In vitro model was performed on these enzymes and the results showed that methanol extract of Scoparia dulcis was effective to check the postprandial glucose level. The in vivo hypoglycaemic activity of methanol extract of Scoparia dulcis was performed on streptozotocin-induced diabetes mellitus showed significant inhibition of blood glucose level as compared to control and similar to that of standard glibenclamide. The overall data potentiates the traditional value of Scoparia dulcis as an antidiabetic drug.
authors.affiliation: Gayatri College of Pharmacy, Jamadarpali, Sambalpur-768 200, India.
authors.forename: M R
authors.initials: MR
authors.lastname: Mishra
authors.affiliation: Gayatri College of Pharmacy, Jamadarpali, Sambalpur-768 200, India.
authors.forename: A
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Gayatri College of Pharmacy, Jamadarpali, Sambalpur-768 200, India.
authors.forename: D K
authors.initials: DK
authors.lastname: Pradhan
authors.affiliation: School of Chemistry, Sambalpur University, Burla, Sambalpur-768 019, India.
authors.forename: A K
authors.initials: AK
authors.lastname: Panda
authors.affiliation: School of Chemistry, Sambalpur University, Burla, Sambalpur-768 019, India.
authors.forename: R K
authors.initials: RK
authors.lastname: Behera
authors.affiliation: Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835 215, India.
authors.forename: S
authors.initials: S
authors.lastname: Jha
keywords: Hypoglycaemic; antioxidant; polyphenol; postprandial