title: Clinical significance of combined detection of serum tumor markers in diagnosis of patients with ovarian cancer.
abstract: OBJECTIVE
  To explore the predictive value of tumor markers, including cancer antigen 72-4 (CA72-4), cancer antigen 15-3 (CA15-3) and cancer antigen 125 (CA125), in single or combined detection, for the diagnosis of ovarian cancer.
  
  
  METHODS
  120 patients diagnosed with ovarian cancer from August 2011 to March 2013 and 80 patients diagnosed with benign ovarian tumors were enrolled in this test, along with 50 health examination women randomly selected from the database as controls. Serum levels of CA72-4, CA15-3 and CA125 in this study were determined by electrochemiluminescence (ECL).
  
  
  RESULTS
  Serum levels of CA72-4, CA15-3 and CA125 in ovarian cancer were higher than those in healthy group and benign group (P<0.01).The sensitivity of combined detection of those three tumor markers for diagnosis of ovarian cancer was obviously higher than with single detection with each marker (P<0.01).
  
  
  CONCLUSIONS
  CA72-4, CA15-3 and CA125 could be a good combination in the diagnosis of ovarian cancer. Patients whose tumor markers continue to increase should be highly suspected of malignancy.
authors.affiliation: Department of Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China E-mail : shallyvans@hotmail.com, shallyvans@126.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Bian
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Xian-Juan
authors.initials: XJ
authors.lastname: Kou
authors.forename: Tian-Zhou
authors.initials: TZ
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Ming
mesh_terms: D000368:Aged; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D010051:Ovarian Neoplasms / Q000097:blood*
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; C083825:CA-72-4 antigen; D018396:Mucin-1