title: Heat-shock protein-70 and regulatory T cell-mediated protection from ischemic injury.
abstract: Heat preconditioning induces heat-shock protein-70 upregulation and protects from renal ischemia/reperfusion injury. Kim et al. report that heat-shock protein-70 and regulatory T cells play a key role in protective heat preconditioning. This work reinforces the utility of inducing heat-shock protein-70 expression by pharmacological agents as a novel therapy for the prevention and treatment of ischemic kidney injury.
authors.affiliation: MRC Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: O'Neill
authors.affiliation: MRC Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.
authors.forename: Jeremy
authors.initials: J
authors.lastname: Hughes
mesh_terms: D058186:Acute Kidney Injury / Q000276:immunology*; D000818:Animals; D018840:HSP70 Heat-Shock Proteins / Q000502:physiology*; D008297:Male; D015427:Reperfusion Injury / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
chemical_list: D018840:HSP70 Heat-Shock Proteins