title: Studies of macrophage cellular response to the extracellular hydrogen peroxide by tilapia model.
abstract: Reactive oxygen species (ROS) may act as signaling molecules in the physiology responses and the present study aims to investigate the effect of extracellular hydrogen peroxide on macrophages cellular response. The results obtained in the present study showed that the extracellular hydrogen peroxide affectively alter the membrane potential of the cell membrane and ion exchange channels in the cell membrane through intracellular NAD turnover that may lead to an intracellular calcium ion concentration alteration and subsequently induce the downstream signal activation.
authors.affiliation: Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Wu
authors.affiliation: Department of Aquaculture, National Taiwan Ocean University, Keelung 20248, Taiwan.
authors.forename: Fan-Hua
authors.initials: FH
authors.lastname: Nan
authors.affiliation: Freshwater Aquaculture Research Center, Fisheries Research Institute, Council of Agriculture, Changhua 50562, Taiwan.
authors.forename: Shih-Ling
authors.initials: SL
authors.lastname: Huang
authors.affiliation: Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Chien-Mei
authors.initials: CM
authors.lastname: Hsiao
authors.affiliation: Department of Life Science, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Kam-Chiu
authors.initials: KC
authors.lastname: Lai
authors.affiliation: Department of Life Science, National Taiwan University, Taipei 10617, Taiwan.
authors.forename: Chung-Lun
authors.initials: CL
authors.lastname: Lu
authors.affiliation: Institute of Fisheries Science, National Taiwan University, Taipei 10617, Taiwan; Department of Life Science, National Taiwan University, Taipei 10617, Taiwan. Electronic address: snchen@ntu.edu.tw.
authors.forename: Shiu-Nan
authors.initials: SN
authors.lastname: Chen
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007249:Inflammation; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000494:pharmacology*; D017210:Tilapia / Q000378:metabolism*
chemical_list: D007473:Ion Channels; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide
keywords: Cellular physiology; Hydrogen peroxide; Inflammation; Macrophage