title: Large solvation effect in the optical rotatory dispersion of norbornenone.
abstract: The anomalously large chiroptical response of (1R,4R)-norbornenone has been probed under complementary vapor-phase and solution-phase conditions to assess the putative roles of environmental perturbations. Measurements of the specific rotation for isolated (gas-phase) molecules could not be reproduced quantitatively by comprehensive quantum-chemical calculations based on density-functional or coupled-cluster levels of linear-response theory, which suggests that higher-order treatments may be needed to accurately predict such intrinsic behavior. A substantial, yet unexpected, dependence of the dispersive optical activity on the nature (phase) of the surrounding medium has been uncovered, with the venerable Lorentz local-field correction reproducing solvent-mediated trends in rotatory dispersion surprisingly well, whereas more modern polarizable continuum models for implicit solvation performed less satisfactorily.
authors.affiliation: Department of Chemistry, Yale University, New Haven, CT 06520-8107 (USA).
authors.forename: Priyanka
authors.initials: P
authors.lastname: Lahiri
authors.forename: Kenneth B
authors.initials: KB
authors.lastname: Wiberg
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Vaccaro
authors.forename: Marco
authors.initials: M
authors.lastname: Caricato
authors.forename: T Daniel
authors.initials: TD
authors.lastname: Crawford
keywords: ab initio calculations; chirality; chiroptical spectroscopy; optical activity; solvent effects