title: Partially dissociable roles of OFC and ACC in stimulus-guided and action-guided decision making.
abstract: Recently, the functional specialization of prefrontal areas of the brain, and, specifically, the functional dissociation of the orbitofrontal cortex (OFC) and the anterior cingulate cortex (ACC), during decision making have become a particular focus of research. A number of neuropsychological and lesion studies have shown that the OFC and ACC have dissociable functions in various dimensions of decision making, which are supported by their different anatomical connections. A recent single-neuron study, however, described a more complex picture of the functional dissociation between these two frontal regions during decision making. Here, I discuss the results of that study and consider alternative interpretations in connection with other findings.
authors.affiliation: Visual Cognition Laboratory, Department of Medicine, University of Fribourg, Fribourg, Switzerland; and Center for Cognition, University of Fribourg, Fribourg, Switzerland.
authors.forename: Abbas
authors.initials: A
authors.lastname: Khani
mesh_terms: D000818:Animals; D003657:Decision Making; D006179:Gyrus Cinguli / Q000166:cytology / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*
keywords: action; anterior cingulate cortex; decision making; dissociation; orbitofrontal cortex; outcome; single neuron; stimulus