title: Modulation of adipose tissue thermogenesis as a method for increasing energy expenditure.
abstract: There is a renewed interest in the role of adipose tissue in energy utilization and thermogenesis and its potential application in the treatment of metabolic disorders such as obesity and diabetes. The last few years have seen the identification of brown adipose tissue capable of metabolic activation in adult humans, the possibility of recruiting 'beige' adipocytes to increase energy expenditure, and the implication of molecules such as FGF21 and irisin in inducing increases in energy expenditure in adipose tissue. The translation of these findings into human trials to deliver safe, efficacious medicines remains a challenge.
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer, Inc., 620 Memorial Dr., Cambridge, MA 02139, USA. Electronic address: matthew.sammons@pfizer.com.
authors.forename: Matthew F
authors.initials: MF
authors.lastname: Sammons
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer, Inc., 620 Memorial Dr., Cambridge, MA 02139, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Price
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D022722:Thermogenesis / Q000187:drug effects / Q000502:physiology*
chemical_list: D000318:Adrenergic beta-Agonists
keywords: Beige adipose; Brown adipose tissue; Thermogenesis