title: [A case of advanced colorectal carcinoma with aggressively growing liver metastases successfully managed with the induction of cetuximab single-agent therapy].
abstract: Chemotherapy for advanced colorectal cancer has developed remarkably in recent years. However, medical practitioners are occasionally unwilling to initiate a standard multi-agent chemotherapy regimen for patients whose general condition is poor. We report the case of a patient with aggressively growing liver metastases and impending organ failure and symptoms who was successfully treated with the induction of anti-epidermal growth factor receptor( EGFR) antibody single- agent therapy. With the selection of some biomarkers, induction with anti-EGFR antibody single-agent therapy might be a beneficial therapeutic option for the treatment of colorectal cancer in patients with imminent organ failure and severe symptoms caused by local tumor progression.
authors.affiliation: Dept. of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University.
authors.forename: Naoki
authors.initials: N
authors.lastname: Tanimine
authors.forename: Takao
authors.initials: T
authors.lastname: Hinoi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Egi
authors.forename: Manabu
authors.initials: M
authors.lastname: Shimomura
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Adachi
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Saito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sawada
authors.forename: Masashi
authors.initials: M
authors.lastname: Miguchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Niitsu
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Mukai
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohdan
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000068818:Cetuximab; D018450:Disease Progression; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068818:Cetuximab