title: Decision making during interneuron migration in the developing cerebral cortex.
abstract: Appropriate interneuron migration and distribution is essential for the construction of functional neuronal circuitry and the maintenance of excitatory/inhibitory balance in the brain. Gamma-aminobutyric acid (GABA)ergic interneurons originating from the ventral telencephalon choreograph a complex pattern of migration to reach their target destinations within the developing brain. This review examines the cellular and molecular underpinnings of the major decision-making steps involved in this process of oriental navigation of cortical interneurons.
authors.affiliation: UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
authors.forename: Jiami
authors.initials: J
authors.lastname: Guo
authors.affiliation: UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Department of Cell Biology and Physiology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address: anton@med.unc.edu.
authors.forename: E S
authors.initials: ES
authors.lastname: Anton
mesh_terms: D000818:Animals; D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology / Q000254:growth & development*; D006801:Humans; D007395:Interneurons / Q000166:cytology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005680:gamma-Aminobutyric Acid
keywords: cerebral cortex; interneurons; laminar organization; migration; neural circuitry