title: Morbidity of Chagas heart disease in the microregion of Rio Negro, Amazonian Brazil: a case-control study.
abstract: A case-control study on the morbidity of Chagas heart disease was carried out in the municipality of Barcelos in the microregion of the Rio Negro, state of Amazonas. One hundred and six individuals, who were serologically positive for Trypanosoma cruzi infection, as confirmed by at least two techniques with different principles, were matched according to age and sex with an equal number of seronegative individuals. The cases and controls were evaluated using an epidemiological questionnaire and clinical, electrocardiograph and echocardiograph examinations. In the seroepidemiological evaluation, 62% of the interviewees recognised triatomines and most of them confirmed that they had seen these insects in the piassava plantations of the riverside communities of the Negro River tributaries. Of the seropositive patients, 25.8% affirmed that they had been stung by the triatomines and 11.7% denied having been stung. The principal clinical manifestations of the seropositive individuals were palpitations, chest pain and dyspnoea upon effort. Cardiac auscultation revealed extrasystoles, bradycardia and systolic murmurs. The electrocardiographic alterations were ventricular extrasystoles, left and right bundle branch block, atrioventricular block and primary T wave alterations. The echocardiogram was altered in 22.6% of the seropositive individuals and in 8.5% of the seronegative individuals.
authors.affiliation: Laboratório de Doenças Parasitárias, Instituto Oswaldo Cruz.
authors.forename: José Rodrigues
authors.initials: JR
authors.lastname: Coura
authors.affiliation: Department of Neglected Tropical Disease, World Health Organization, Switzerland, Geneva.
authors.forename: Pedro Albajar
authors.initials: PA
authors.lastname: Viñas
authors.affiliation: Médicos sem Fronteiras, Brasil.
authors.forename: Lucia Maria
authors.initials: LM
authors.lastname: Brum-Soares
authors.affiliation: Instituto de Pesquisa Clínica-Fiocruz, Brasil, Rio de JaneiroRJ.
authors.forename: Andréa Silvestre de
authors.initials: AS
authors.lastname: Sousa
authors.affiliation: Instituto de Pesquisa Clínica-Fiocruz, Brasil, Rio de JaneiroRJ.
authors.forename: Sérgio Salles
authors.initials: SS
authors.lastname: Xavier
mesh_terms: D000818:Animals; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D002598:Chagas Cardiomyopathy / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D004452:Echocardiography; D004562:Electrocardiography; D006801:Humans; D007303:Insect Vectors / Q000145:classification; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology