title: Clinical outcome of autologous bone marrow aspirates concentrate (BMAC) injection in degenerative arthritis of the knee.
abstract: OBJECTIVE
  As a treatment method of degenerative arthritis of knee, this study evaluated the clinical efficacy of the intra-articular injection of autologous bone marrow aspirates concentrate (BMAC) with adipose tissue.
  
  
  METHODS
  Between April 2011 and May 2012, 41 patients (75 knees) who were diagnosed as a degenerative knee arthritis and underwent the BMAC injection with adipose tissue were included in this study. Mean age was 60.7 years old (ranged 53-80). Kellgren-Lawrence grade was used for assessing radiologic degree of osteoarthritis; there were each 12, 24, 33, and 6 cases of grade I, II, III, and IV. At preoperative and postoperative 3, 6, and 12 months, pain score using visual analogue scale (VAS) and functional scales were used for evaluation.
  
  
  RESULTS
  After the procedure, mean VAS score was decreased from 7.0 preoperatively to 4.1, 3.5, and 3.3 postoperatively 3, 6, and 12 months. And functional scores were also improved; International Knee Documentation Committee score (from 37.7 preoperatively to 59.3, 66.3, 69.3 postoperatively), SF-36 health score (from 31.5 to 43.5, 45.6, 47.7), knee and osteoarthritis outcome score (from 43.1 to 64.9, 68.5, 70.6), Lysholm Knee Questionnaire (from 37.3 to 65.4, 68.6, 71.0) were all increased after the procedure. When classified according to K-L grade, the improvement of VAS score in grade IV group was 8.2 preoperatively to 5.5, 5.3, and 5.7 postoperatively, which was significantly poorer than those of grade I-III groups. In the knee functional scales, similar pattern was checked.
  
  
  CONCLUSIONS
  BMAC injection significantly improved both knee pain and functions in the patients with degenerative arthritis of knee. Also, the injection would be more effective in early to moderate phases.
authors.affiliation: Department of Orthopaedic Surgery, Kosin University Gospel Hospital, 34 Am-nam Dong, Seo Gu, Pusan, 602-030, Republic of Korea, jdkim207@hanmail.net.
authors.forename: Jae-Do
authors.initials: JD
authors.lastname: Kim
authors.forename: Gun Woo
authors.initials: GW
authors.lastname: Lee
authors.forename: Gu Hee
authors.initials: GH
authors.lastname: Jung
authors.forename: Cheung Kue
authors.initials: CK
authors.lastname: Kim
authors.forename: Taehun
authors.initials: T
authors.lastname: Kim
authors.forename: Jin Hyung
authors.initials: JH
authors.lastname: Park
authors.forename: Seong Sook
authors.initials: SS
authors.lastname: Cha
authors.forename: Young-Bin
authors.initials: YB
authors.lastname: You
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018771:Arthralgia / Q000601:surgery; D016026:Bone Marrow Transplantation / Q000379:methods*; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular / Q000379:methods; D007719:Knee Joint / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000601:surgery; D016896:Treatment Outcome