title: Locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of colon.
abstract: Apocrine carcinoma is a rare malignant adnexal neoplasm. The differential diagnosis between apocrine carcinoma and cutaneous metastasis is often difficult. Here, we report a case of locally recurrent penile apocrine carcinoma initially diagnosed as metastatic adenocarcinoma of the colon. A 75-year-old man with a history of surgical resection due to sigmoid colon cancer and penile metastasis two years prior to this study presented with a nodule at the left penile base. He underwent a wide local resection of the penile mass under a suggested preoperative diagnosis of extra-mammary Paget's disease (EMPD) associated with previous sigmoid colon cancer. However, the previously and currently resected penile masses were identified as primary apocrine carcinoma upon hematoxylin and eosin (H&E) staining and immunohistochemical staining. Although the incidence is extremely rare, both clinicians and pathologists should be alert to the possibility of synchronous double primary apocrine carcinoma in cancer patients with malignant cutaneous lesions.
authors.affiliation: Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Ok-Jun
authors.initials: OJ
authors.lastname: Lee
authors.affiliation: Department of Urology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Seok-Joong
authors.initials: SJ
authors.lastname: Yun
authors.affiliation: Department of Urology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Wun-Jae
authors.initials: WJ
authors.lastname: Kim
authors.affiliation: Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Song-Yi
authors.initials: SY
authors.lastname: Choi
authors.affiliation: Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Ho-Chang
authors.initials: HC
authors.lastname: Lee
authors.affiliation: Department of Pathology, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Hyung-Geun
authors.initials: HG
authors.lastname: Song
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Sung-Nam
authors.initials: SN
authors.lastname: Lim
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Ki-Hyeong
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Seung-Taik
authors.initials: ST
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju 361-711, South Korea.
authors.forename: Hye-Suk
authors.initials: HS
authors.lastname: Han
keywords: Apocrine glands; carcinoma; colon cancer; penis