title: Full-genome analysis of a canine pneumovirus causing acute respiratory disease in dogs, Italy.
abstract: An outbreak of canine infectious respiratory disease (CIRD) associated to canine pneumovirus (CnPnV) infection is reported. The outbreak occurred in a shelter of the Apulia region and involved 37 out of 350 dogs that displayed cough and/or nasal discharge with no evidence of fever. The full-genomic characterisation showed that the causative agent (strain Bari/100-12) was closely related to CnPnVs that have been recently isolated in the USA, as well as to murine pneumovirus, which is responsible for respiratory disease in mice. The present study represents a useful contribution to the knowledge of the pathogenic potential of CnPnV and its association with CIRD in dogs. Further studies will elucidate the pathogenicity and epidemiology of this novel pneumovirus, thus addressing the eventual need for specific vaccines.
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Pinto
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Viviana
authors.initials: V
authors.lastname: Mari
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Elia
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Larocca
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Camero
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Terio
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Losurdo
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.affiliation: Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D001483:Base Sequence; D004196:Disease Outbreaks; D004283:Dog Diseases / Q000453:epidemiology* / Q000821:virology*; D004285:Dogs; D005260:Female; D023061:Gene Order; D016679:Genome, Viral; D007558:Italy / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D018111:Pneumovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D018186:Pneumovirus Infections / Q000662:veterinary*; D016415:Sequence Alignment