title: 2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography initial staging impacts on survival in Hodgkin lymphoma.
abstract: OBJECTIVE
  To assess the prognostic value and risk classification improvement of metabolic staging (MS) with Initial 2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography (FDG-PET) in initial staging of Hodgkin's Lymphoma (HL) patients to predict 5 years overall survival (5y-OS) and event free survival (EFS).
  
  
  METHODS
  A total of 275 patients were included in this retrospective study, 155 patients were staged with conventional anatomical staging (AS), and 120 also submitted to MS (FDG-PET). Prognostic analysis compared 5y-OS and 5y-EFS of patients staged with AS and MS. Risk-adjusted models incorporated clinical risk factors, computed tomography and FDG-PET staging.
  
  
  RESULTS
  During the follow up of 267 evaluated patients, 220 (122 AS and 98 MS) achieved complete remission after first-line therapy (median follow-up: 70 ± 29 mo), treatment failure occurred in 79 patients and 34 died. The 5y-EFS for early vs advanced disease in AS patients was 79.3% and 66.7%, and 85.6% and 53.6% in MS patients, respectively (P < 0.01). The 5y-OS for early and advanced disease with AS was 91.3% and 81.5%, and 97.5% and 80.7% for patients staged with MS, respectively. Cox proportional hazards analysis demonstrated that FDG-PET added signiﬁcant prognostic information and improved risk prediction (P = 0.02).
  
  
  CONCLUSIONS
  Initial staging FDG-PET could be used as an accurate and independent predictor of OS and EFS in HL, with impact in 5y-EFS and OS.
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: Juliano J
authors.initials: JJ
authors.lastname: Cerci
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: Camila C G
authors.initials: CC
authors.lastname: Linardi
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: Luís F
authors.initials: LF
authors.lastname: Pracchia
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: José Soares
authors.initials: JS
authors.lastname: Junior
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: Evelinda
authors.initials: E
authors.lastname: Trindade
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: Dominique
authors.initials: D
authors.lastname: Delbeke
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: Rodrigo J
authors.initials: RJ
authors.lastname: Cerci
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: Robert
authors.initials: R
authors.lastname: Carr
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: José C
authors.initials: JC
authors.lastname: Meneghetti
authors.affiliation: Juliano J Cerci, José Soares Junior, José C Meneghetti, Department of Nuclear Medicine, Heart Institute (InCor), University of São Paulo Medical School, São Paulo 05403-900, Brazil.
authors.forename: Valeria
authors.initials: V
authors.lastname: Buccheri
keywords: 2-[18F]-fluoro-2-desoxy-D-glucose positron emission tomography; Hodgkin disease; Neoplasm staging; Positron-emission tomography; Prognosis