title: New topical treatments for psoriasis.
abstract: BACKGROUND
  Psoriasis is a common immune-mediated disorder that in 70% of cases appears in mild or mild-to-moderate form. Psoriasis is usually treated with topical medications and/or phototherapy with variable efficacy in controlling the disease.
  
  
  METHODS
  For the past three decades, research has been focused on systemic agents for the treatment of moderate-to-severe psoriasis, particularly with the introduction of biologic agents or 'small molecules'. In parallel, novel advances in topical antipsoriatic agents have been made, experiencing a 'new era', with the development of new formulations and the identification of new therapeutic targets. These agents, having a different spectrum of action from traditional agents, are actually being tested in pre-marketing clinical trials and they may potentially represent promising treatment options that could enlarge the therapeutic armamentarium for the treatment of psoriasis.
  
  
  CONCLUSIONS
  Future antipsoriatic topical agents show new modality of action in blocking the pathogenic process leading to psoriatic plaque formation.
authors.affiliation: University of Rome Tor Vergata, Department of Dermatology , Via Montpellier 1, 00133 Rome , Italy +39 339 566 8320 ; +39 062 090 2742 ; chimenti@dermatologica.it.
authors.forename: Andrea
authors.initials: A
authors.lastname: Chiricozzi
authors.forename: Rossella
authors.initials: R
authors.lastname: Pitocco
authors.forename: Rosita
authors.initials: R
authors.lastname: Saraceno
authors.forename: Steven Paul
authors.initials: SP
authors.lastname: Nistico
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giunta
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
mesh_terms: D000287:Administration, Topical; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
chemical_list: D003879:Dermatologic Agents