title: New routes towards reutericyclin analogues.
abstract: A range of N-acylpyrrolo[3,4-c]isoxazoles and derived N-acyltetramides has been prepared via a nitrile oxide dipolar cycloaddition approach, as analogues of the acyltetramic acid metabolite reutericyclin, of interest for its antibiotic potential against Gram-positive bacteria including hospital-acquired infections of resistant Clostridium difficile.
authors.affiliation: Department of Chemistry, Loughborough University, Leicester, LE11 3TU, UK. r.c.f.jones@lboro.ac.uk.
authors.forename: Raymond C F
authors.initials: RC
authors.lastname: Jones
authors.forename: James P
authors.initials: JP
authors.lastname: Bullous
authors.forename: Carole C M
authors.initials: CC
authors.lastname: Law
authors.forename: Mark R J
authors.initials: MR
authors.lastname: Elsegood
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry*; D016360:Clostridioides difficile / Q000187:drug effects; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry; D007778:Lactobacillus / Q000737:chemistry; D008958:Models, Molecular; D013720:Tenuazonic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D007555:Isoxazoles; C416127:reutericyclin; D013720:Tenuazonic Acid