title: Severe skin ulceration associated with Wegener's granulomatosis: successful treatment with hyperbaric oxygen and prostaglandin E1.
abstract: Abstract A 36-year-old woman patient with intractable skin ulcers associated with Wegener's granulomatosis was successfully cured by combination therapy with hyperbaric oxygenation therapy (HBO) and intravenous prostaglandin E1 (PGE1). Treatment for 4 months with prednisolone, intravenous PGE1, and cyclophosphamide did not result in healing of the multiple skin lesions on her legs. Repeated HBO with intravenous PGE1 therapy over 6 months resulted in a complete healing of the skin ulcers. We recommend the use of HBO combined with PGE1 for severe cutaneous lesions associated with generalized vasculitis.
authors.affiliation: First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine , 1-1 Iseigaoka, Yahatanishi-ku, Kita-kyushu 807-8555 , Japan.
authors.forename: Keisuke
authors.initials: K
authors.lastname: Nakatsuka
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Saito
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kohshi
authors.forename: Ikuhide
authors.initials: I
authors.lastname: Konda
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Tanaka