title: Association between lean mass, fat mass, and bone mineral density: a meta-analysis.
abstract: BACKGROUND
  Body weight is the most important anthropometric determinant of bone mineral density (BMD). Body weight is mainly made up of lean mass (LM) and fat mass (FM), and which component is more important to BMD has been a controversial issue.
  
  
  OBJECTIVE
  This study sought to compare the magnitude of association between LM, FM, and BMD by using a meta-analytic approach.
  
  
  METHODS
  Using an electronic and manual search, we identified 44 studies that had examined the correlation between LM, FM, and BMD between 1989 and 2013. These studies involved 20,226 men and women (4966 men and 15,260 women) aged between 18 and 92 years. We extracted the correlations between LM, FM, and BMD at the lumbar spine, femoral neck, and whole body. The synthesis of correlation coefficients was done by the random-effects meta-analysis model.
  
  
  RESULTS
  The overall correlation between LM and femoral neck BMD (FNBMD) was 0.39 (95% confidence interval, 0.34 to 0.43), which was significantly higher than the correlation between FM and FNBMD (0.28; 95% confidence interval, 0.22 to 0.33). The effect of LM on FNBMD in men (r=0.43) was greater than that in women (r=0.38). In premenopausal women, the effect of LM on BMD was greater than the effect of FM (r=0.45 vs r=0.30); however, in postmenopausal women, the effects of LM and FM on BMD were comparable (r=0.33 vs r=0.31).
  
  
  CONCLUSIONS
  LM exerts a greater effect on BMD than FM in men and women combined. This finding underlines the concept that physical activity is an important component in the prevention of bone loss and osteoporosis in the population.
authors.affiliation: Department of Internal Medicine (L.T.H.-P., U.D.T.N.), Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam; Department of Rheumatology (L.T.H.-P.), People's Hospital 115, Ho Chi Minh City, Vietnam; Osteoporosis and Bone Biology Program (T.V.N.), Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW 2010, Australia; Bone and Muscle Research Group (T.V.N.), Ton Duc Thang University, Ho Chin Minh City, Vietnam; and St Vincent's Clinical School (T.V.N.), and School of Public Health and Community Medicine (T.V.N.), UNSW Medicine, University of New South Wales, Sydney, NSW 2010, Australia.
authors.forename: Lan T
authors.initials: LT
authors.lastname: Ho-Pham
authors.forename: Uyen D T
authors.initials: UD
authors.lastname: Nguyen
authors.forename: Tuan V
authors.initials: TV
authors.lastname: Nguyen
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D013851:Thinness / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D055815:Young Adult