title: Rhodium, iridium, and ruthenium half-sandwich picolinamide complexes as anticancer agents.
abstract: Novel rhodium, iridium, and ruthenium half-sandwich complexes containing (N,N)-bound picolinamide ligands have been prepared for use as anticancer agents. The complexes show promising cytotoxicities, with the presence, position, and number of halides having a significant effect on the corresponding IC50 values. One ruthenium complex was found to be more cytotoxic than cisplatin on HT-29 and MCF-7 cells after 5 days and 1 h, respectively, and it remains active with MCF-7 cells even under hypoxic conditions, making it a promising candidate for in vivo studies.
authors.affiliation: School of Chemistry, University of Leeds , Leeds, LS2 9JT, United Kingdom.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Almodares
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lucas
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Crossley
authors.forename: Aida M
authors.initials: AM
authors.lastname: Basri
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Pask
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Hebden
authors.forename: Roger M
authors.initials: RM
authors.lastname: Phillips
authors.forename: Patrick C
authors.initials: PC
authors.lastname: McGowan
mesh_terms: D000577:Amides / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015687:Cell Hypoxia; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007495:Iridium / Q000737:chemistry; D061986:MCF-7 Cells; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010848:Picolinic Acids / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry
chemical_list: D000577:Amides; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D010848:Picolinic Acids; D007495:Iridium; D012428:Ruthenium; D012238:Rhodium; C003142:picolinamide