title: [Preoperative chemotherapy for advanced gastric cancer].
abstract: In the present study, we evaluated the outcome of preoperative treatment with S-1 and CDDP for the treatment of advanced gastric cancer. Fifty-five cases of advanced gastric cancer received pre-operative treatment with S-1 and CDDP. The tumor control rate( PR and CR according to RECIST criteria) was 55%. The clinical response and histological response to the treatment and curative resection were closely related to favorable postoperative survival. We noted that patients who demonstrated CR or PR received S-1 as postoperative treatment, whereas those with SD or PD were more likely to receive paclitaxel as postoperative treatment. Preoperative treatment with S-1 and CDDP was not only an effective initial treatment, but also demonstrated favorable results in a S-1 in vivo sensitivity test.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation Toshima Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagahama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ando
authors.forename: Ryota
authors.initials: R
authors.lastname: Seki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiya
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Amagasa
authors.forename: Jun
authors.initials: J
authors.lastname: Takasaki
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kamikozuru
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ganno
authors.forename: Katsunori
authors.initials: K
authors.lastname: Ami
authors.forename: Akira
authors.initials: A
authors.lastname: Fukuda
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Arai
authors.forename: Shikofumi
authors.initials: S
authors.lastname: Tei
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D006801:Humans; D020360:Neoadjuvant Therapy; D009362:Neoplasm Metastasis; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000627:therapeutic use; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel; D002945:Cisplatin