title: Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents.
abstract: Series of 2-pyridineformamide thiosemicarbazones were synthesized. Their preferential cytotoxicity in nutrient deprived medium (NDM) was evaluated using PANC-1 human pancreatic cancer cells by employing an antiausterity strategy. 2-Pyridineformamide thiosemicarbazones induced apoptosis and exhibited preferential cytotoxic activity toward PANC-1 cells in NDM, with potencies in the submicromolar range. These compounds are potential candidates for the development of therapeutics against pancreatic cancer.
authors.affiliation: Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
authors.forename: Bhushan
authors.initials: B
authors.lastname: Shakya
authors.affiliation: Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
authors.forename: Paras Nath
authors.initials: PN
authors.lastname: Yadav
authors.affiliation: Frontier Research Core for Life Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
authors.forename: Jun-ya
authors.initials: JY
authors.lastname: Ueda
authors.affiliation: Frontier Research Core for Life Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. Electronic address: suresh@inm.u-toyama.ac.jp.
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005559:Formamides / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011725:Pyridines / Q000737:chemistry* / Q000627:therapeutic use; D013882:Thiosemicarbazones / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: C532279:2-pyridineformamide; D000970:Antineoplastic Agents; D005559:Formamides; D011725:Pyridines; D013882:Thiosemicarbazones
keywords: 2-Pyridineformamide thiosemicarbazones; Antiausterity agents; Apoptosis; Nutrition starvation; Pancreatic cancer