title: Self-consumption: the interplay of autophagy and apoptosis.
abstract: Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of cells within organisms, respectively, and many stress pathways sequentially elicit autophagy, and apoptosis within the same cell. Generally autophagy blocks the induction of apoptosis, and apoptosis-associated caspase activation shuts off the autophagic process. However, in special cases, autophagy or autophagy-relevant proteins may help to induce apoptosis or necrosis, and autophagy has been shown to degrade the cytoplasm excessively, leading to 'autophagic cell death'. The dialogue between autophagy and cell death pathways influences the normal clearance of dying cells, as well as immune recognition of dead cell antigens. Therefore, the disruption of the relationship between autophagy and apoptosis has important pathophysiological consequences.
authors.affiliation: 1] Institut national de la santé et de la recherche médicale (INSERM), U1138, F-94805 Villejuif, France. [2] Université Paris Descartes/Paris V, Sorbonne Paris Cité, F-75006 Paris, France.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Mariño
authors.affiliation: 1] Institut national de la santé et de la recherche médicale (INSERM), U1138, F-94805 Villejuif, France. [2] Université Paris Descartes/Paris V, Sorbonne Paris Cité, F-75006 Paris, France.
authors.forename: Mireia
authors.initials: M
authors.lastname: Niso-Santano
authors.affiliation: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
authors.forename: Eric H
authors.initials: EH
authors.lastname: Baehrecke
authors.affiliation: 1] Institut national de la santé et de la recherche médicale (INSERM), U1138, F-94805 Villejuif, France. [2] Université Paris Descartes/Paris V, Sorbonne Paris Cité, F-75006 Paris, France. [3] Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, F-75006 Paris, France. [4] Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, F-75015 Paris. [5] Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, F-94805 Villejuif, France.
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer
mesh_terms: D017209:Apoptosis / Q000235:genetics*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism*; D001343:Autophagy / Q000235:genetics*; D020169:Caspases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009336:Necrosis / Q000235:genetics; D015388:Organelles / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D051017:Apoptosis Regulatory Proteins; D020169:Caspases