title: [CD4+, CD8+ AND CD19+ cells in individuals with dyslipidemia].
abstract: BACKGROUND
  The past decade has witnessed an increasing recognition that inflammatory mechanisms play a central role in the pathogenesis of atherosclerosis and its complications. Recently, attention was focused on the potential role of plasma markers of inflammation as risk predictors among those at risk for cardiovascular events. Of these potential markers, C-reactive protein (CRP), IL6, metalloproteinases, ICAM, VCAM and other molecules, have been extensively studied. On the other hand, to our knowledge, there are only a few studies on the role of inflammatory cells, like T and B lymphocytes in the atherosclerosis.
  
  
  METHODS
  By flow cytometry analysis we have determined on dyslipidemic people and on a control group, the percentage of some peripheral inflammatory cells, like CD3+, CD4+, CD8+, CD19+, CD56+, CD56CD8+, DN, CD25+, CD26+, CD25CD3+, CD26CD3+, CD25CD26CD3+, CCR5+, CCR5CD3+, CCR5CD4+, HLADR+, HLADRCD4+, HLADRCD8h+, HLADRCD8low+, HLADRCD8+, CD95+, CD95CD95L+, CD3CD95+, CD3CD95L+, CD62L+, CD3CD62L+, CD69+, CD69CD3+ e CD69CD4+.
  
  
  RESULTS
  In the present study we have particularly studied the percentage of CD4+, CD8+ and CD19+ cells. The CD4+ cells have been significantly reduced in the people with dyslipidemia.
  
  
  CONCLUSIONS
  We do not know the peripheral numbers of the subtype Th1 and Th2, neither the percentage of CD4+CD25+ cells (regulatory T cells). We have not find any differences on the percentage from the CD8+ and CD19+ cells.
  
  
  CONCLUSIONS
  In spite of the identified limitations resulting from the small-sized samples, it was possible to show a reduction of some molecules after application of acetylsalicylic acid.
authors.affiliation: Serviço de Medicina Interna. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
authors.forename: Jose
authors.initials: J
authors.lastname: Pereira de Moura
authors.affiliation: Laboratório de Imunologia. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.
authors.forename: Manuel
authors.initials: M
authors.lastname: Santos Rosa
authors.affiliation: Laboratório de Imunologia. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.
authors.forename: Vera
authors.initials: V
authors.lastname: Alves
authors.affiliation: Laboratório de Patologia Geral. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.
authors.forename: Anabela
authors.initials: A
authors.lastname: Mota Pinto
authors.affiliation: Instituto de Higiene e Medicina Social. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.
authors.forename: Victor
authors.initials: V
authors.lastname: Rodrigues
authors.affiliation: Serviço de Medicina Interna. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Silva
authors.affiliation: Serviço de Medicina Interna. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
authors.forename: J J
authors.initials: JJ
authors.lastname: Alves de Moura
mesh_terms: D018941:Antigens, CD19; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D050171:Dyslipidemias / Q000097:blood* / Q000276:immunology*; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets
chemical_list: D018941:Antigens, CD19