title: Synthesis of primary amides via copper-catalyzed aerobic decarboxylative ammoxidation of phenylacetic acids and α-hydroxyphenylacetic acids with ammonia in water.
abstract: A Cu2O-catalyzed aerobic oxidative decarboxylative ammoxidation to primary benzamides from phenylacetic acids and α-hydroxyphenylacetic acids is developed. A variety of primary benzamides could be prepared smoothly, in good to excellent yields, by means of a one-pot domino protocol combining decarboxylation, dioxygen activation, oxidative C-H bond functionalization, and amidation reactions.
authors.affiliation: Institute of Next Generation Matter Transformation, College of Chemical Engineering at Huaqiao University , 668 Jimei Boulevard, Xiamen, Fujian, 361021, P. R. China.
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Song
authors.forename: Qiang
authors.initials: Q
authors.lastname: Feng
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000641:Ammonia / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003653:Decarboxylation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry; D010648:Phenylacetates / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000577:Amides; D001549:Benzamides; D010648:Phenylacetates; D014867:Water; D000641:Ammonia; D003300:Copper; D010100:Oxygen