title: The evaluation of the biomedical effectiveness of poly(amido)amine dendrimers generation 4.0 as a drug and as drug carriers: a systematic review and meta-analysis.
abstract: The purpose of this study was to investigate the evaluation of the biomedical effectiveness of poly(amido)amine dendrimers generation 4.0 (PAMAM G4) as a drug and as drug carriers by a systematic review of literature and meta-analysis. The results obtained from meta-analysis concluded that drug therapy reduces the change of parameters in relation to the control. The impact of the drug administered to change the test parameters are dependent on the type of tissue. PAMAM G4 may be effective in vitro and in vivo as a drug and drug carriers and may have appropriate applications in various fields of medicine. PAMAM G4 dendrimers hold promises for nanomedicine.
authors.affiliation: Department of Mathematic and Biostatistic, Medical University of Lublin, 4 Jaczewskiego Street, 20-090 Lublin, Poland.
authors.forename: Marian
authors.initials: M
authors.lastname: Jędrych
authors.affiliation: Department of Cosmetology, University of Information Technology and Management in Rzeszów, 2 Sucharskiego Street, 35-325 Rzeszów, Poland. Electronic address: k_borowska@wp.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Borowska
authors.affiliation: Department of Histology and Embryology, Center for Biostructure, Medical University of Warsaw, Chałubinskiego 5 Street, 02-004 Warsaw, Poland.
authors.forename: Ryszard
authors.initials: R
authors.lastname: Galus
authors.affiliation: Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, 11 Radziwiłowska Street, 20-080 Lublin, Poland.
authors.forename: Barbara
authors.initials: B
authors.lastname: Jodłowska-Jędrych
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D050997:Nanomedicine; D009757:Nylons / Q000737:chemistry / Q000494:pharmacology
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D009757:Nylons; C520550:PAMAM-G4
keywords: Generation 4.0; Meta-analysis; PAMAM G4; Poly(amido)amine dendrimers; Review