title: Emerging principles for the therapeutic exploitation of glycosylation.
abstract: Glycosylation plays a key role in a wide range of biological processes. Specific modification to a glycan's structure can directly modulate its biological function. Glycans are not only essential to glycoprotein folding, cellular homeostasis, and immune regulation but are involved in multiple disease conditions. An increased molecular and structural understanding of the mechanistic role that glycans play in these pathological processes has driven the development of therapeutics and illuminated novel targets for drug design. This knowledge has enabled the treatment of metabolic disorders and the development of antivirals and shaped cancer and viral vaccine strategies. Furthermore, an understanding of glycosylation has led to the development of specific drug glycoforms, for example, monoclonal antibodies, with enhanced potency.
authors.affiliation: Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Dalziel
authors.forename: Max
authors.initials: M
authors.lastname: Crispin
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Scanlan
authors.forename: Nicole
authors.initials: N
authors.lastname: Zitzmann
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Dwek
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry; D000998:Antiviral Agents / Q000737:chemistry; D019496:Cancer Vaccines / Q000737:chemistry; D015195:Drug Design; D006017:Glycolipids / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use*; D006023:Glycoproteins / Q000737:chemistry* / Q000378:metabolism / Q000627:therapeutic use*; D006031:Glycosylation; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy; D011134:Polysaccharides / Q000096:biosynthesis / Q000737:chemistry / Q000145:classification; D014765:Viral Vaccines / Q000737:chemistry
chemical_list: D000911:Antibodies, Monoclonal; D000998:Antiviral Agents; D019496:Cancer Vaccines; D006017:Glycolipids; D006023:Glycoproteins; D011134:Polysaccharides; D014765:Viral Vaccines