title: [Indoleamine 2, 3-dioxygenase activity for breast cancer patients with recurrence 5 or more years after surgery].
abstract: We evaluated the significance of indoleamine 2, 3-dioxygenase( IDO) in breast cancer patients with recurrence 5 or more years after surgery. IDO activity can be measured by the tryptophan (Trp)/kynurenine (Kyn) ratio. Trp and Kyn were measured by high-performance liquid chromatography( HPLC). We encountered 32 patients in whom breast cancer recurred 5 or more years after surgery. The mean age of the patients was 56.8 years. The mean duration of years since the initial treatment for breast cancer was 9.3±3.8 years. The rate of hormone receptor positivity was 93.8%. Twelve patients were suitable for locoregional therapy and the remaining 20 patients required chemotherapy. The patients suitable for locoregional therapy had a better prognosis than those who required chemotherapy. The correlation of the Trp/Kyn ratio between these 2 groups (locoregional therapy group and chemotherapy group) was studied. The Trp/Kyn ratio was higher in patients suitable for locoregional therapy than in those who received chemotherapy. The prognosis was better in patients with a high Trp/Kyn ratio than in those with a low Trp/Kyn ratio. These results suggest that determining the Trp/Kyn ratio was useful in the prognosis of patients with breast cancer that recurred 5 or more years after surgery.
authors.affiliation: Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakurai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujisaki
authors.forename: Saki
authors.initials: S
authors.lastname: Nagashima
authors.forename: Tetsuyo
authors.initials: T
authors.lastname: Maeda
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Tomita
authors.forename: Shuhei
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Enomoto
authors.forename: Sadao
authors.initials: S
authors.lastname: Amano
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000737:chemistry / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D007737:Kynurenine / Q000032:analysis; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D013997:Time Factors
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007737:Kynurenine