title: Role of lipid peroxide in the neurodegenerative disorders.
abstract: Nervous system controls all the organs in the living like a symphony. In this chapter, the mechanism of neuronal death in aged is discussed in relation to oxidative stress. Polyunsaturated fatty acid (PUFA) is known to be rich in the membranous component of the neurons and plays an important role in maintaining the neuronal functions. Recent reports revealed that oxidation of omega-3 and omega-6 PUFAs, such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), are potent antioxidant but simultaneously, their oxidation products are potentially toxic. In this chapter, the existence of early oxidation products of PUFA is examined in the samples from neurodegenerative disorders and the cellular model. Accumulation of proteins with abnormal conformation is suggested to induce neuronal death by disturbance of proteolysis and mitochondrial function. The role of lipid peroxide and lipid-derived aldehyde adduct proteins is discussed in relation to brain ageing and age-related neurodegeneration.
authors.affiliation: Department of Cognitive Brain Science, National Institute for Geriatrics and Gerontology, 35 Morioka, Obu, Aichi, 474-8511, Japan, maruyama@ncgg.go.jp.
authors.forename: Wakako
authors.initials: W
authors.lastname: Maruyama
authors.forename: Masayo
authors.initials: M
authors.lastname: Shaomoto-Nagai
authors.forename: Yoji
authors.initials: Y
authors.lastname: Kato
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Hisaka
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Osawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Naoi
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology; D015525:Fatty Acids, Omega-3 / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000378:metabolism; D018384:Oxidative Stress; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D051844:alpha-Synuclein