title: Alcohol-induced severe acute pancreatitis followed by hemolytic uremic syndrome managed with continuous renal replacement therapy.
abstract: BACKGROUND
  Acute kidney injury in patients with acute pancreatitis carries a poor prognosis. Hemolytic uremic syndrome (HUS) is characterized by non-immune hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney, and though rare in adults it is associated with high mortality and a high rate of chronic renal failure.
  
  
  METHODS
  Herein, we report a case of alcohol-induced acute pancreatitis in a 38-year-old Chinese female complicated by HUS. Her renal function progressively deteriorated in 2 days, and daily continuous renal replacement therapy (CRRT) was thus performed for a total of 13 treatments. She also received intermittent transfusions of fresh frozen plasma. Her renal failure was successfully managed, with subsequent return of normal renal function. She was discharged 1 month after admission and follow-up at 3 months revealed normal urea and creatinine.
  
  
  CONCLUSIONS
  CRRT was shown to be useful for the treatment of HUS following acute pancreatitis. Prior case reports and our case should remind clinicians that HUS is a possible complication of acute pancreatitis. This study highlights the importance of early diagnosis and prompt initiation of CRRT to prevent mortality and improve outcomes.
authors.affiliation: Department of Nephrology, Tongji Hospital, Tongji University, Alley 578, Xiangyin Road, Wujiaochang Town, 200433 Shanghai, China. fupeng1966@qq.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.forename: Ai-hong
authors.initials: AH
authors.lastname: Yuan
authors.forename: Chun-hua
authors.initials: CH
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Hai-yang
authors.initials: HY
authors.lastname: Wu
mesh_terms: D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications* / Q000175:diagnosis / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D019512:Pancreatitis, Alcoholic / Q000150:complications* / Q000209:etiology*; D010951:Plasma Exchange; D017582:Renal Replacement Therapy; D016896:Treatment Outcome