title: Receptor status of tumor as prognostic factor in patients with bilateral breast cancer.
abstract: OBJECTIVE
  To determine the receptor status of tumors as prognostic factor in development of bilateral breast cancer (BBC) and factor of prognosis of disease.
  
  
  METHODS
  272 cases of BBC during the period from 1995 to 2011 in different oncological institutions of Ukraine have been analyzed.
  
  
  RESULTS
  Patients with metachronous BBC with positive status of hormone receptors (HR) of tumors have significantly better indices of overall and progression-free survival (three-years - 95%, five-years - 72%), than patients with HR-negative status (among them nobody has survived over 5 years). In patients with synchronous BBC, the receptor status of tumors has similar influence on the prognosis of survival. Nevertheless, indices of overall survival (65%) and progression-free survival (66%) in HR-positive patients were lower than that at metachronous BBC (overall survival and progression-free survival - 72%).
  
  
  CONCLUSIONS
  Synchronous breast cancer has more aggressive clinical course than metachronous one. It was determined significant influence of receptor status of tumors on the overall survival and progression-free survival in patients with BBC.
authors.affiliation: Uzhgorod National University, Uzhgorod 88000, Ukraine.
authors.forename: D Y
authors.initials: DY
authors.lastname: Tsyhyka
authors.affiliation: Uzhgorod National University, Uzhgorod 88000, Ukraine.
authors.forename: Y S
authors.initials: YS
authors.lastname: Hotko
authors.affiliation: Uzhgorod National University, Uzhgorod 88000, Ukraine.
authors.forename: O T
authors.initials: OT
authors.lastname: Devinyak
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D012307:Risk Factors
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone