title: Cytological characteristics of lung washings from children in depleted uranium stroked region.
abstract: The study was based on theoretical interpretation of authentic findings of Lupus Erythematosus Cells (LEC) in bronchoalveolar lavage (BAL) samples of children who underwent flexible bronchoscopy for clinical symptoms and radiological changes consistent with persistent pulmonary infiltrates during the first year after the bombing of Serbia in 1999. Differential cell counts were compared and statistical significance of differences for estimated cell population percentages calculated in groups of LEC positive (LEC+) and LEC negative (LEC-) BAL specimens. Significant increase of percentages of neutrophils and eosinophils and decreased percentages of macrophages were found in the group of LEC+ in comparison with LEC- BAL specimens (p less than 0.05, p less than 0.001, p less than 0.001, respectively). Presence of decreased percentages of cells of monocyte-macrophage lineage with consequent expansion of white blood cells in BAL, argue for understanding the nature of LEC+ alveolitis as a possible nonspecific finding of radiation-induced biological response of pulmonary tissue. LEC phenomenon may be understood as an early radio adaptive tissue response. Depleted uranium (DU) radiotoxic effect with concomitant alpha particles radiation, has been associated with unpredictable and everlasting biological effects. The emission of radiation in the course of several decades due to corrosion of scattered remnants of DU armaments, which has been potentiated by the repeated bombing of the regions within range of the transfer of radioactive particles by air, strikes a broad territory and numerous populations, and unavoidably leads to in vivoPetkau effect. Except the war, peacetime nuclear disasters in various parts of the world, such as Fukushima, Chernobyl and others, contribute to this effect too. In this way, the Petkau effect is a challenge for science to declare the future health strategy with the main goal focused on minimizing the early, as well as delayed in vivo effects of depleted uranium.
authors.affiliation: Clinical Center of Serbia, Center of Nuclear Medicine, Belgrade, Serbia.
authors.forename: S
authors.initials: S
authors.lastname: Zunic
mesh_terms: D000512:Alpha Particles / Q000009:adverse effects; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D001999:Bronchoscopy; D002450:Cell Communication; D002648:Child; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology*; D011650:Pulmonary Alveoli / Q000473:pathology / Q000528:radiation effects*; D011832:Radiation Injuries / Q000097:blood* / Q000150:complications; D011848:Radioactive Pollutants / Q000009:adverse effects*; D014501:Uranium / Q000009:adverse effects*
chemical_list: D011848:Radioactive Pollutants; D014501:Uranium