title: Epidemiological trends of dengue disease in Brazil (2000-2010): a systematic literature search and analysis.
abstract: A literature survey and analysis was conducted to describe the epidemiology of dengue disease in Brazil reported between 2000 and 2010. The protocol was registered on PROSPERO (CRD42011001826: http://www.crd.york.ac.uk/prospero/display_record.asp?ID=CRD42011001826). Between 31 July and 4 August 2011, the published literature was searched for epidemiological studies of dengue disease, using specific search strategies for each electronic database. A total of 714 relevant citations were identified, 51 of which fulfilled the inclusion criteria. The epidemiology of dengue disease in Brazil, in this period, was characterized by increases in the geographical spread and incidence of reported cases. The overall increase in dengue disease was accompanied by a rise in the proportion of severe cases. The epidemiological pattern of dengue disease in Brazil is complex and the changes observed during this review period are likely to have been influenced by multiple factors. Several gaps in epidemiological knowledge regarding dengue disease in Brazil were identified that provide avenues for future research, in particular, studies of regional differences, genotype evolution, and age-stratified seroprevalence.
  
  
  BACKGROUND
  PROSPERO registration number: CRD42011001826.
authors.affiliation: Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, Brazil.
authors.forename: Maria Glória
authors.initials: MG
authors.lastname: Teixeira
authors.affiliation: Universidade Federal de Goiás, Goiânia, Brazil.
authors.forename: João Bosco
authors.initials: JB
authors.lastname: Siqueira
authors.affiliation: Sanofi Pasteur, Global Epidemiology, Lyon, France.
authors.forename: Germano L C
authors.initials: GL
authors.lastname: Ferreira
authors.affiliation: Sanofi Pasteur, São Paulo, Brazil.
authors.forename: Lucia
authors.initials: L
authors.lastname: Bricks
authors.affiliation: Communigen Ltd., The Magdalen Centre, Oxford Science Park, Oxford, United Kingdom.
authors.forename: Graham
authors.initials: G
authors.lastname: Joint
mesh_terms: D001938:Brazil / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D015994:Incidence; D019371:Topography, Medical