title: A study on the extracts of Cuscuta reflexa Roxb. in treatment of cyclophosphamide induced alopecia.
abstract: BACKGROUND
  Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. Hair loss is one of the most feared side effects of chemotherapy. Plants have been widely used for hair growth promotion since ancient times in Ayurveda, Chinese and Unani systems of medicine. The effect of extracts of Cuscuta reflexa Roxb. in testosterone induced alopecia was reported.
  
  
  OBJECTIVE
  In the present study, the efficacies of the extracts of Cuscuta reflexa in promoting hair growth in cyclophosphamide-induced hair loss have been determined.
  
  
  METHODS
  The study was performed by treated with petroleum ether and ethanolic extract of Cuscuta reflexa at the dose 250 mg/kg in male swiss albino rats. Cyclophosphamide (125 mg/kg) was used to induce alopecia.
  
  
  RESULTS
  Groups treated with extracts of plant showed hair regrowth. Histopathology and gross morphologic observations for hair regrowth at shaved sites revealed active follicular proliferation.
  
  
  CONCLUSIONS
  It concluded that extracts of Cuscuta reflexa shown to be capable of promoting follicular proliferation or preventing hair loss in cyclophosphamide-induced hair fall.
authors.forename: Satish
authors.initials: S
authors.lastname: Patel
authors.forename: Vikas
authors.initials: V
authors.lastname: Sharma
authors.forename: Nagendra S
authors.initials: NS
authors.lastname: Chauhan
authors.affiliation: Department of Pharmaceutical Sciences, Doctor Hari Singh Gour Vishwavidyalaya, Sagar 470 003, M,P, India. vkdixit2011@rediffmail.com.
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Dixit