title: Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility.
abstract: Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
authors.affiliation: Drug Delivery, Disposition and Dynamics, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. chris.porter@monash.edu.
authors.forename: Hywel D
authors.initials: HD
authors.lastname: Williams
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Sahbaz
authors.forename: Leigh
authors.initials: L
authors.lastname: Ford
authors.forename: Tri-Hung
authors.initials: TH
authors.lastname: Nguyen
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Scammells
authors.forename: Christopher J H
authors.initials: CJ
authors.lastname: Porter
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D003613:Danazol / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D052578:Ionic Liquids / Q000737:chemistry*; D051381:Rats; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D052578:Ionic Liquids; D014867:Water; D003613:Danazol