title: Body composition in 98 patients awaiting kidney transplantation.
abstract: OBJECTIVE
  Recent data suggest that the nutritional status of patients who are on the waiting list for kidney transplantation, influence outcomes after renal transplantation. Body composition (BC) analysis is rarely included in pretransplant evaluation. The aim of this study was to determine how alteration of the BC of these patients could influence pretransplant and post-transplant care.
  
  
  METHODS
  We compared the BC of French patients on a waiting list for kidney transplantation to a sex- and age-matched healthy, European control population. Patients were included when listed for kidney grafting in a prospective longitudinal study (CORPOS). Biological nutritional parameters, fat free mass (FFM) and fat mass (FM) estimated by dual-energy x-ray absorptiometry (DXA) were assessed on the day of wait-list registration. FFM and FM index (FFMi - FMi) are the ratio of FFM and FM to height squared. Results are expressed as median (range). These indexes were compared with previous study values used as a normal range in nutritional assessment and clinical practice.
  
  
  RESULTS
  The study included 28 women and 70 men aged 25.3 to 65.9 y. Body mass index ranged from 16.8 kg/m² to 39.4 kg/m². Compared with controls, FMi was higher in women (10.6 kg/m² [3.7-18.6 kg/m²]) than in men (8.1 kg/m² [3.5-13.3 kg/m²] in M) and FFMi was lower in women (14.3 kg/m² [11.8-21.4 kg/m²]) than in men (17.9 kg/m² [13.9-24.2 kg/m²]) (P < 0.01), reflecting an abnormal distribution of body compartments. All biological parameters were within the normal range.
  
  
  CONCLUSIONS
  BC abnormalities, which can only be detected with the use of DXA, are present in patients on a kidney transplantation waiting list. Detection of these abnormalities could influence the post-transplantation survey in order to prevent the frequent risk for developing metabolic complications after the procedure.
authors.affiliation: Renal Transplant Unit, Pellegrin Hospital, Bordeaux, France. Electronic address: karine.moreau@chu-bordeaux.fr.
authors.forename: Karine
authors.initials: K
authors.lastname: Moreau
authors.affiliation: Renal Transplant Unit, Pellegrin Hospital, Bordeaux, France.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Desseix
authors.affiliation: Clinical Epidemiology Unit, Bordeaux University Hospital, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Germain
authors.affiliation: Laboratory of Nuclear Medicine, Pellegrin Hospital, Bordeaux, France.
authors.forename: Nicole
authors.initials: N
authors.lastname: Barthe
authors.affiliation: Renal Transplant Unit, Pellegrin Hospital, Bordeaux, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Bachelet
authors.affiliation: Renal Transplant Unit, Pellegrin Hospital, Bordeaux, France.
authors.forename: Delphine
authors.initials: D
authors.lastname: Morel
authors.affiliation: Renal Transplant Unit, Pellegrin Hospital, Bordeaux, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Merville
authors.affiliation: Renal Transplant Unit, Pellegrin Hospital, Bordeaux, France.
authors.forename: Lionel
authors.initials: L
authors.lastname: Couzi
authors.affiliation: Clinical Epidemiology Unit, Bordeaux University Hospital, France; INSERM U897, Bordeaux, France.
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Thiebaut
authors.affiliation: AURAD Aquitaine, Gradignan, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Chauveau
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods; D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005602:France; D006801:Humans; D016030:Kidney Transplantation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D011184:Postoperative Period; D057234:Preoperative Period; D011446:Prospective Studies; D012016:Reference Values; D014280:Triglycerides / Q000097:blood; D014850:Waiting Lists
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: Body composition; DXA; Fat mass; Fat-free mass; Kidney transplantation candidates