title: Mixed ligand complex via zinc(II)-mediated in situ oxidative heterocyclization of hydrochloride salt of 2-chlorobenzaldehyde hydralazine hydrazone as potential of antihypertensive agent.
abstract: An unusual tetrahedral mixed ligand Zn(II) complex ZnT(L)Cl, where L = 2-chlorobenzaldehyde hydralazine hydrazone and T = in situ generated 3-(2-chlorophenyl)-1,2,4-triazolo[3,4-a]phthalazine is reported. Structure of the fused triazole has been confirmed by single crystal X-ray diffraction studies. Structure of Co(II), Ni(II), Cu(II) and Zn(II) complexes has been confirmed by spectral and analytical methods. Metal complexes have exhibited better activity in the fructose induced hypertension studies in animal model and are comparable with the standard.
authors.affiliation: Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, Karnataka, India.
authors.forename: Raghavendra P
authors.initials: RP
authors.lastname: Bakale
authors.affiliation: Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, Karnataka, India.
authors.forename: Ganesh N
authors.initials: GN
authors.lastname: Naik
authors.affiliation: H.S.K. College of Pharmacy, Bagalkot 587101, Karnataka, India.
authors.forename: Chandrashekhar V
authors.initials: CV
authors.lastname: Mangannavar
authors.affiliation: H.S.K. College of Pharmacy, Bagalkot 587101, Karnataka, India.
authors.forename: Iranna S
authors.initials: IS
authors.lastname: Muchchandi
authors.affiliation: Southern Federal University, Rostov-on-Don, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: Shcherbakov
authors.affiliation: SAFC Pharmorphix, A Sigma-Aldrich Company, 250 Cambridge Science Park, Milton Road, Cambridge CB4 0WE, UK.
authors.forename: Chris
authors.initials: C
authors.lastname: Frampton
authors.affiliation: Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad 580003, Karnataka, India. Electronic address: kbgudasi@gmail.com.
authors.forename: Kalagouda B
authors.initials: KB
authors.lastname: Gudasi
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001547:Benzaldehydes / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D003300:Copper / Q000737:chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D005632:Fructose / Q000494:pharmacology; D006830:Hydralazine / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy; D008024:Ligands; D008297:Male; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry; D010084:Oxidation-Reduction; D051381:Rats; D017207:Rats, Sprague-Dawley; D013818:Thermogravimetry; D015032:Zinc / Q000737:chemistry*
chemical_list: D000959:Antihypertensive Agents; D001547:Benzaldehydes; D056831:Coordination Complexes; D006835:Hydrazones; D008024:Ligands; D006830:Hydralazine; D005632:Fructose; D003035:Cobalt; D003300:Copper; D009532:Nickel; C059341:2-chlorobenzaldehyde; D015032:Zinc
keywords: 1,2,4-Triazole; Antihypertensive activity; Hydralazine; Hydrazone; Metal complex