title: The selective cyclooxygenase-2 inhibitor, the compound 11b improves haloperidol induced catatonia by enhancing the striatum dopaminergic neurotransmission.
abstract: A substantial amount of evidence has proposed an important role for Cyclooxygenase-2 (COX-2) enzyme in brain diseases and affiliate disorders. The purpose of this research was studying the effects of COX-2 selective inhibition on haloperidol-induced catatonia in an animal model of drug overdose and Parkinson's disease (PD). In this study, the effect of acute and Sub-chronic oral administration of a new selective COX-2 inhibitor, i.e. the compound 11b or 1-(Phenyl)-5-(4-methylsulfonylphenyl)-2-ethylthioimidazole, in a dosage of 2, 4 and 8 mg/kg on haloperidol-induced catatonia was evaluated and compared to the standard drug scopolamine (1 mg/kg) by microanalysis of Striatum dopaminergic neurotransmission. The results showed a very high potency for 11b in improving the catalepsy by enhancing the dopaminergic neurotranmission (p < 0.05). In addition, statistical analysis showed the dose- and time-dependent behavior of the observed protective effect of 11b against the haloperidol-induced catatonia and enhancement of the dopaminergic neurotransmission. These findings are additional pharmacological data that suggest the effectiveness of COX-2 inhibition in treatment of schizophreny-associated rigidity.
authors.affiliation: Depattment of Physiology and Physiology Research Center, School of Medicine, Jondishapour University of Medical Sciences, Ahwaz, Iran.
authors.forename: Hadi
authors.initials: H
authors.lastname: Fathi-Moghaddam
authors.affiliation: Department of Pharmacology, Razi institute for drug research, College of Medicine, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Shafiee Ardestani
authors.affiliation: Department of Medicinal Chemistry and Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran .
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saffari
authors.affiliation: Depattment of Physiology and Physiology Research Center, School of Medicine, Jondishapour University of Medical Sciences, Ahwaz, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Jabbari Arabzadeh
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mitra
authors.initials: M
authors.lastname: Elmi
keywords: Catalepsy; Compound 11b; Dopaminergic neurotransmission; Nigrostriatal