title: Taking the lymphatic route: dendritic cell migration to draining lymph nodes.
abstract: In contrast to leukocyte migration through blood vessels, trafficking via lymphatic vessels (LVs) is much less well characterized. An important cell type migrating via this route is antigen-presenting dendritic cells (DCs), which are key for the induction of protective immunity as well as for the maintenance of immunological tolerance. In this review, we will summarize and discuss current knowledge of the cellular and molecular events that control DC migration from the skin towards, into, and within LVs, followed by DC arrival and migration in draining lymph nodes. Finally, we will discuss potential strategies to therapeutically target this migratory step to modulate immune responses.
authors.affiliation: Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang-Pauli Str. 10, HCI H413, 8093, Zurich, Switzerland.
authors.forename: Alvaro
authors.initials: A
authors.lastname: Teijeira
authors.forename: Erica
authors.initials: E
authors.lastname: Russo
authors.forename: Cornelia
authors.initials: C
authors.lastname: Halin
mesh_terms: D000818:Animals; D002465:Cell Movement; D003713:Dendritic Cells / Q000502:physiology*; D004729:Endothelium, Lymphatic / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000628:therapy; D008198:Lymph Nodes / Q000502:physiology*; D042601:Lymphatic Vessels / Q000502:physiology*; D057705:Transendothelial and Transepithelial Migration