title: Myocardial blood flow measurement with a conventional dual-head SPECT/CT with spatiotemporal iterative reconstructions - a clinical feasibility study.
abstract: Cardiac single photon emission computed tomography (SPECT) cameras typically rotate too slowly around a patient to capture changes in the blood pool activity distribution and provide accurate kinetic parameters. A spatiotemporal iterative reconstruction method to overcome these limitations was investigated. Dynamic rest/stress (99m)Tc-methoxyisobutylisonitrile ((99m)Tc-MIBI) SPECT/CT was performed along with reference standard rest/stress dynamic positron emission tomography (PET/CT) (13)N-NH3 in five patients. The SPECT data were reconstructed using conventional and spatiotemporal iterative reconstruction methods. The spatiotemporal reconstruction yielded improved image quality, defined here as a statistically significant (p<0.01) 50% contrast enhancement. We did not observe a statistically significant difference between the correlations of the conventional and spatiotemporal SPECT myocardial uptake K 1 values with PET K 1 values (r=0.25, 0.88, respectively) (p<0.17). These results indicate the clinical feasibility of quantitative, dynamic SPECT/CT using (99m)Tc-MIBI and warrant further investigation. Spatiotemporal reconstruction clearly provides an advantage over a conventional reconstruction in computing K 1.
authors.affiliation: Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
authors.forename: Fares
authors.initials: F
authors.lastname: Alhassen
authors.affiliation: Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA ; Nuclear Medicine Service, San Francisco Veterans Affairs Medical Center San Francisco, CA, USA.
authors.forename: Nhan
authors.initials: N
authors.lastname: Nguyen
authors.affiliation: Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
authors.forename: Sukhkarn
authors.initials: S
authors.lastname: Bains
authors.affiliation: Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
authors.forename: Robert G
authors.initials: RG
authors.lastname: Gould
authors.affiliation: Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
authors.forename: Youngho
authors.initials: Y
authors.lastname: Seo
authors.affiliation: Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Bacharach
authors.affiliation: Philips Healthcare San Jose, CA, USA.
authors.forename: Xiyun
authors.initials: X
authors.lastname: Song
authors.affiliation: Philips Healthcare San Jose, CA, USA.
authors.forename: Lingxiong
authors.initials: L
authors.lastname: Shao
authors.affiliation: Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA ; Department of Radiotracer Development & Imaging Technology, Lawrence Berkeley National Laboratory Berkeley, CA, USA.
authors.forename: Grant T
authors.initials: GT
authors.lastname: Gullberg
authors.affiliation: Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California San Francisco, CA, USA ; Department of Radiotracer Development & Imaging Technology, Lawrence Berkeley National Laboratory Berkeley, CA, USA.
authors.forename: Carina Mari
authors.initials: CM
authors.lastname: Aparici
keywords: 99mTc-MIBI; Dynamic SPECT; SPECT/CT; myocardial perfusion imaging; spatiotemporal reconstruction; uptake rate constant