title: MTP gene polymorphisms and postprandial lipemia in familial combined hyperlipidemia: effects of treatment with atorvastatin.
abstract: BACKGROUND
  The microsomal triglyceride transfer protein (MTP) is involved in hepatic and intestinal apoB secretion. We studied the effect of the functional MTP-493G/T polymorphism on fasting and postprandial lipoproteins in patients with familial combined hyperlipidemia (FCH) before and after treatment with atorvastatin.
  
  
  METHODS
  Eight FCH heterozygote carriers of the rare -493T allele were compared to 9 matched FCH homozygotes for the wild-type allele in a pilot study. Oral fat loading tests were carried out to measure triglycerides (TG) and apo B48 and B100 in the different fractions of triglyceride-rich lipoproteins (TRLs) before and after treatment with atorvastatin.
  
  
  RESULTS
  Before treatment, TG were similar between the -493T allele carriers and non-carriers. In the T-allele carriers, a trend was observed for increased postprandial apo B48 and B100 concentrations in Sf >400 and Sf 60-400 compared to non-carriers. After treatment, fasting and postprandial TG were significantly lowered in carriers of the T allele, but atorvastatin had no effect on postprandial TG in non-carriers. Atorvastatin resulted in similar reductions of apo B48 and B100 in TRLs in both groups.
  
  
  CONCLUSIONS
  The MTP-493G/T polymorphism modulates postprandial apo B48 and apo B100 of TRLs in FCH. Atorvastatin decreases postprandial TG in T-allele carriers with FCH.
authors.affiliation: Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands.
authors.forename: Boudewijn
authors.initials: B
authors.lastname: Klop
authors.affiliation: Tytgat Institute for Liver and Intestinal Research, Amsterdam Medical Centre, Amsterdam, The Netherlands.
authors.forename: Caroline
authors.initials: C
authors.lastname: Verseyden
authors.affiliation: Unitat de Recerca en Lípids i Arteriosclerosi, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Ribalta
authors.affiliation: Unitat de Recerca en Lípids i Arteriosclerosi, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain; U-705 CIBERER, Barcelona, Spain.
authors.forename: Juliana
authors.initials: J
authors.lastname: Salazar
authors.affiliation: Unitat de Recerca en Lípids i Arteriosclerosi, CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Masana
authors.affiliation: Department of Internal Medicine, Sint Franciscus Gasthuis, Rotterdam, The Netherlands. Electronic address: m.castrocabezas@sfg.nl.
authors.forename: Manuel Castro
authors.initials: MC
authors.lastname: Cabezas
mesh_terms: D000328:Adult; D000483:Alleles; D001055:Apolipoproteins B / Q000378:metabolism; D000069059:Atorvastatin; D002352:Carrier Proteins / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D006950:Hyperlipidemia, Familial Combined / Q000188:drug therapy* / Q000235:genetics; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D019518:Postprandial Period; D011758:Pyrroles / Q000008:administration & dosage / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D001055:Apolipoproteins B; D002352:Carrier Proteins; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008074:Lipoproteins; D011758:Pyrroles; D014280:Triglycerides; C106092:microsomal triglyceride transfer protein; D000069059:Atorvastatin
keywords: Atorvastatin; Atorvastatina; Familial combined hyperlipidemia; Hiperlipemia familiar combinada; Microsomal triglyceride transfer protein (MTP)