title: Assembly of an injectable noncytotoxic peptide-based hydrogelator for sustained release of drugs.
abstract: A new synthetic tripeptide-based hydrogel has been discovered at physiological pH and temperature. This hydrogel has been thoroughly characterized using different techniques including field emission scanning electron microscopic (FE-SEM) and high-resolution transmission electron microscopic (HR-TEM) imaging, small- and wide-angle X-ray diffraction analyses, FT-IR, circular dichroism, and rheometric analyses. Moreover, this gel exhibits thixotropy and injectability. This hydrogel has been used for entrapment and sustained release of an antibiotic vancomycin and vitamin B12 at physiological pH and temperature for about 2 days. Interestingly, MTT assay of these gelator molecules shows almost 100% cell viability of this peptide gelator, indicating its noncytotoxicity.
authors.affiliation: Department of Biological Chemistry, Indian Association for the Cultivation of Science , Jadavpur, Kolkata 700032, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Baral
authors.forename: Subhasish
authors.initials: S
authors.lastname: Roy
authors.forename: Ashkan
authors.initials: A
authors.lastname: Dehsorkhi
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hamley
authors.forename: Saswat
authors.initials: S
authors.lastname: Mohapatra
authors.forename: Surajit
authors.initials: S
authors.lastname: Ghosh
authors.forename: Arindam
authors.initials: A
authors.lastname: Banerjee
mesh_terms: D002470:Cell Survival; D016503:Drug Delivery Systems; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D061986:MCF-7 Cells; D015394:Molecular Structure; D009842:Oligopeptides / Q000737:chemistry*; D013696:Temperature; D014640:Vancomycin / Q000737:chemistry*; D014805:Vitamin B 12 / Q000737:chemistry*
chemical_list: D009842:Oligopeptides; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D014640:Vancomycin; D014805:Vitamin B 12