title: Corticosteroid-resistant multiple colonic ulcers in a patient with systemic lupus erythematosus/systemic sclerosis overlap syndrome effectively treated with intravenous cyclophosphamide pulse therapy.
abstract: Abstract We report a rare case of a 17-year-old female with overlap syndrome (systemic lupus erythematosus and systemic sclerosis) who developed severe abdominal pain and bloody diarrhea accompanied by central nervous system lupus. Colonoscopy revealed multiple irregular and linear ulcers throughout the colon, which were resistant to corticosteroid pulse therapy and plasma exchange. The patient finally recovered after treatment with a relatively low dose of monthly intravenous cyclophosphamide (250 mg/m(2)) pulse therapy.
authors.affiliation: Third Department of Internal Medicine, Hamamatsu University School of Medicine , 1-20-1 Handayama, Hamamatsu 431-3192 , Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ota
authors.forename: Norio
authors.initials: N
authors.lastname: Nozue
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Dei
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kondo
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohashi