title: Cerebrospinal fluid biomarkers in clinical subtypes of early-onset Alzheimer's disease.
abstract: OBJECTIVE
  Accurate diagnosis of sporadic early-onset Alzheimer's disease (EOAD) can be challenging, and cerebrospinal fluid (CSF) biomarkers may assist in this process. We compared CSF indices between three EOAD subtypes: amnestic, logopenic progressive aphasia (LPA), and posterior cortical atrophy (PCA).
  
  
  METHODS
  We identified 21 amnestic EOAD, 20 LPA, and 12 PCA patients with CSF data, which included amyloid β1-42 (Aβ42), total tau (t-tau), phospho-tau181 (p-tau), and Aβ42/t-tau index (ATI) levels.
  
  
  RESULTS
  Aβ42 and ATI levels were similar across groups, but t-tau and p-tau levels were significantly lower in PCA patients.
  
  
  CONCLUSIONS
  The Aβ42 and ATI data confirm the commonality of the Aβ pathology in EOAD. The lower tau indices in PCA patients may reflect differences in the distribution of neurofibrillary tangles or rates of neurodegeneration.
authors.affiliation: Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Calif., USA.
authors.forename: Edmond
authors.initials: E
authors.lastname: Teng
authors.forename: Tritia R
authors.initials: TR
authors.lastname: Yamasaki
authors.forename: Michelle
authors.initials: M
authors.lastname: Tran
authors.forename: Julia J
authors.initials: JJ
authors.lastname: Hsiao
authors.forename: David L
authors.initials: DL
authors.lastname: Sultzer
authors.forename: Mario F
authors.initials: MF
authors.lastname: Mendez
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000145:classification; D016229:Amyloid beta-Peptides; D015415:Biomarkers / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments; D010766:Phosphorylation; D012189:Retrospective Studies; D016875:tau Proteins
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; C054369:MAPT protein, human; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins