title: Cholesterol's aliphatic side chain modulates membrane properties.
abstract: The influence of cholesterol's alkyl side chain on membrane properties was studied using a series of synthetic cholesterol derivatives without a side chain or with a branched side chain consisting of 5 to 14 carbon atoms. Cholesterol's side chain is crucial for all membrane properties investigated and therefore essential for the membrane properties of eukaryotic cells.
authors.affiliation: Institut für Medizinische Physik und Biophysik, Universität Leipzig, Härtelstrasse 16-18, 04107 Leipzig (Germany).
authors.forename: Holger A
authors.initials: HA
authors.lastname: Scheidt
authors.forename: Thomas
authors.initials: T
authors.lastname: Meyer
authors.forename: Jörg
authors.initials: J
authors.lastname: Nikolaus
authors.forename: Dong Jae
authors.initials: DJ
authors.lastname: Baek
authors.forename: Ivan
authors.initials: I
authors.lastname: Haralampiev
authors.forename: Lars
authors.initials: L
authors.lastname: Thomas
authors.forename: Robert
authors.initials: R
authors.lastname: Bittman
authors.forename: Peter
authors.initials: P
authors.lastname: Müller
authors.forename: Andreas
authors.initials: A
authors.lastname: Herrmann
authors.forename: Daniel
authors.initials: D
authors.lastname: Huster
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D002462:Cell Membrane / Q000737:chemistry; D002784:Cholesterol / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010713:Phosphatidylcholines / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D015060:1,2-Dipalmitoylphosphatidylcholine; D002784:Cholesterol; C028694:1-palmitoyl-2-oleoylphosphatidylcholine
keywords: diffusion; domain formation; lipids; membranes; permeability