title: CT and PET-CT of a dog with multiple pulmonary adenocarcinoma.
abstract: A 10-year-old, intact female Yorkshire terrier had multiple pulmonary nodules on thoracic radiography and ultrasonography with no lesions elsewhere. Computed tomography (CT) and positron emission tomography and computed tomography (PET-CT) using 18F-fluorodeoxyglucose (FDG) were performed to identify metastasis and undetected primary tumors. On CT examination, pulmonary nodules had a hypoattenuating center with thin peripheral enhancement, suggesting ischemic or necrotizing lesion. In PET-CT at 47 min after intravenous injection of 11.1 MBq/kg of FDG, the maximum standardized uptake value of each pulmonary nodule was about from 3.8 to 6.4. There were no abnormal lesions except for four pulmonary nodules on the CT and PET-CT. Primary lung tumor was tentatively diagnosed, and palliative therapy using 2 mg/kg tramadol and 2.2 mg/kg carprofen twice per day was applied. After the dog's euthanasia due to deteriorated clinical signs and poor prognosis, undifferentiated pulmonary adenocarcinoma was diagnosed through histopathologic and immunochemistry examination. To the best of the authors' knowledge, this is the first study of CT and PET-CT features of canine pulmonary adenocarcinoma. In this case, multiple pulmonary adenocarcinoma could be determined on the basis of FDG PET-CT through screening the obvious distant metastasis and/or lymph node invasions and excluding unknown primary tumors.
authors.affiliation: College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea.
authors.forename: Jisun
authors.initials: J
authors.lastname: Kim
authors.forename: Seong Young
authors.initials: SY
authors.lastname: Kwon
authors.forename: Rohani
authors.initials: R
authors.lastname: Cena
authors.forename: Seungjo
authors.initials: S
authors.lastname: Park
authors.forename: Juyeon
authors.initials: J
authors.lastname: Oh
authors.forename: Heejin
authors.initials: H
authors.lastname: Oui
authors.forename: Kyoung-Oh
authors.initials: KO
authors.lastname: Cho
authors.forename: Jung-Joon
authors.initials: JJ
authors.lastname: Min
authors.forename: Jihye
authors.initials: J
authors.lastname: Choi
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000662:veterinary*; D000077192:Adenocarcinoma of Lung; D000818:Animals; D002227:Carbazoles; D004283:Dog Diseases / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000662:veterinary*; D055613:Multiple Pulmonary Nodules / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000662:veterinary*; D010166:Palliative Care / Q000379:methods*; D049268:Positron-Emission Tomography / Q000662:veterinary; D014057:Tomography, X-Ray Computed / Q000662:veterinary; D014147:Tramadol
chemical_list: D002227:Carbazoles; D014147:Tramadol; C007005:carprofen