title: The effect of probiotics on fecal calprotectin in patients with cystic fibrosis.
abstract: Cystic fibrosis (CF) is a common autosomal recessive disorder with different clinical manifestations, mainly in the gastrointestinal and respiratory tracts. This study was performed to access the effect of probiotics in the status of intestinal inflammation in a group of children with CF by measuring the calprotectin level in the fecal samples. Forty-seven patients with CF were enrolled in this study. The fecal calprotectin levels were measured by enzyme linked immunosorbent assay. In a randomized systematic method, the children were divided into two groups - one group received probiotic powder and another received placebo for four weeks. After this period, fecal calprotectin was re-measured. Thirty-one of 47 enrolled patients (65.9%) had abnormal fecal calprotectin levels (>50 g/g). After the intervention, the fecal calprotectin levels decreased in 29 patients (21 patients in the drug group, and only 8 patients in the placebo group; p<0.001). This study showed that about two-thirds of patients with CF had intestinal inflammation based on fecal calprotectin levels. Probiotic administration was shown to decrease calprotectin concentrations and subsequently intestinal inflammation in CF patients.
authors.affiliation: Department of Pediatric Gastroenterology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. dra_yusefi@yahoo.com.
authors.forename: Gholamhossein
authors.initials: G
authors.lastname: Fallahi
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Motamed
authors.forename: Azizollah
authors.initials: A
authors.lastname: Yousefi
authors.forename: Arezoo
authors.initials: A
authors.lastname: Shafieyoun
authors.forename: Mehri
authors.initials: M
authors.lastname: Najafi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Khodadad
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Farhmand
authors.forename: Alireza
authors.initials: A
authors.lastname: Ahmadvand
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D003550:Cystic Fibrosis / Q000188:drug therapy*; D004311:Double-Blind Method; D005243:Feces / Q000737:chemistry*; D006801:Humans; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D019936:Probiotics / Q000627:therapeutic use*
chemical_list: D039841:Leukocyte L1 Antigen Complex