title: Effects of pistachio nuts on body composition, metabolic, inflammatory and oxidative stress parameters in Asian Indians with metabolic syndrome: a 24-wk, randomized control trial.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effects of pistachio nuts as an adjunct to diet and exercise on body composition, metabolic, inflammatory, and oxidative stress parameters in Asian Indians with metabolic syndrome.
  
  
  METHODS
  In this 24-wk randomized control trial, 60 individuals with the metabolic syndrome were randomized to either pistachio (intervention group) or control group (diet as per weight and physical activity profile, modulated according to dietary guidelines for Asian Indians) after 3 wk of a diet and exercise run in. In the first group, unsalted pistachios (20% energy) were given daily. A standard diet and exercise protocol was followed for both groups. Body weight, waist circumference (WC), magnetic resonance imaging estimation of intraabdominal adipose tissue and subcutaneous abdominal adipose tissue, fasting blood glucose (FBG), fasting serum insulin, glycosylated hemoglobin, lipid profile, high-sensitivity C-reactive protein (hs-CRP), adiponectin, free fatty acids (FFAs), tumor necrosis factor (TNF)-α, leptin, and thiobarbituric acid reactive substances (TBARS) were assessed before and after the intervention.
  
  
  RESULTS
  Statistically significant improvement in mean values for various parameters in the intervention group compared with control group were as follows: WC (P < 0.02), FBG (P < 0.04), total cholesterol (P < 0.02), low-density lipoprotein cholesterol (P < 0.006), hs-CRP (P < 0.05), TNF-α (P < 0.03), FFAs (P < 0.001), TBARS (P < 0.01), and adiponectin levels (P < 0.001).
  
  
  CONCLUSIONS
  A single food intervention with pistachios leads to beneficial effects on the cardiometabolic profile of Asian Indians with metabolic syndrome.
authors.affiliation: Diabetes Foundation (India), SDA, New Delhi, India; National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Center of Nutrition & Metabolic Research (C-NET), SDA, New Delhi, India.
authors.forename: Seema
authors.initials: S
authors.lastname: Gulati
authors.affiliation: Diabetes Foundation (India), SDA, New Delhi, India; National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Center of Nutrition & Metabolic Research (C-NET), SDA, New Delhi, India; Fortis C-DOC Center of Excellence for Diabetes, Metabolic Disease and Endocrinology, New Delhi, India; Fortis Flt. Lt. Rajan Dhall Hospital, Vasant Kunj, New Delhi, India. Electronic address: anoopmisra@metabolicresearchindia.com.
authors.forename: Anoop
authors.initials: A
authors.lastname: Misra
authors.affiliation: All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Ravindra Mohan
authors.initials: RM
authors.lastname: Pandey
authors.affiliation: All India Institute of Medical Sciences (AIIMS), New Delhi, India.
authors.forename: Surya Prakash
authors.initials: SP
authors.lastname: Bhatt
authors.affiliation: Diabetes Foundation (India), SDA, New Delhi, India; National Diabetes, Obesity and Cholesterol Foundation (N-DOC), SDA, New Delhi, India; Center of Nutrition & Metabolic Research (C-NET), SDA, New Delhi, India.
authors.forename: Shelza
authors.initials: S
authors.lastname: Saluja
mesh_terms: D052242:Adiponectin / Q000097:blood; D050154:Adiposity; D000328:Adult; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D015444:Exercise; D005215:Fasting; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000178:diet therapy*; D008875:Middle Aged; D009754:Nuts / Q000737:chemistry*; D018384:Oxidative Stress / Q000502:physiology*; D010349:Patient Compliance; D027927:Pistacia / Q000737:chemistry*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D008078:Cholesterol, LDL; D005227:Fatty Acids; D006454:Hemoglobins; D007328:Insulin; D020738:Leptin; D017392:Thiobarbituric Acid Reactive Substances; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
keywords: Metabolic syndrome; Pistachio nut