title: Efficacy and mechanism of action of yin lai tang (lung-stomach treatment) in dyspepsia mouse infected by FM1 virus.
abstract: The aim of this study was to assess the efficacy and elaborate the mechanism of action of Yin Lai Tang (Lung-Stomach Treatment) on dyspepsia mouse infected by FM1 virus. Ninety male, 4 week old Kunming mouse with 12-14 g weight, were randomly divided into 9 groups, i.e., normal, infected, dyspepsia, ribavirin, Shuanghuanglian, Children's indigestion tablet, YinLaiTang high dose, YinLaiTang middle dose and YinLaiTang low dose, and these groups had been treated by according drugs to get objectives. Compared with normal group, lung index significantly (p < 0.01) increased in all groups except ribavirin group where lung index obviously (p < 0.05) increased. There was non-significant (p > 0.05) difference in the values of lung homogenate virus titer between dyspepsia group and other groups. Compared to normal group, there was variable degree of inflammatory cell infiltrations in respiratory tract structures in the animals of other groups, and there was a significant (p < 0.01) increase in the level of serum IL-6, IL-10, and TNF-alpha in infected and dyspepsia group and significant (p < 0.01) decrease in the level of serum IFN-gamma was observed. Compared with single clearing stomach method and single clearing lung approach, lung-stomach treatment reduced the level of IL-6 with non-significant difference (p > 0.05) and increased the level of IL-10 obviously, and compared with the single clearing lung method, there was a significant difference (p < 0.05). Compared with the single clearing stomach method and the single clearing lung method, the lung-stomach treatment method had a better efficacy and showed effects on the expression of pro-inflammatory factor and anti-inflammatory factor.
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China.
authors.forename: Tiegang
authors.initials: T
authors.lastname: Liu
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China.
authors.forename: He
authors.initials: H
authors.lastname: Yu
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China.
authors.forename: Wang
authors.initials: W
authors.lastname: Zhang
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhen
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Li
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China.
authors.forename: Guokai
authors.initials: G
authors.lastname: Lv
authors.affiliation: School of Basic Medical Sciences, Beijing University of Chinese Medicine, Beijing 100029, PR China.
authors.forename: Hong-Xiao
authors.initials: HX
authors.lastname: Gu
authors.affiliation: Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004415:Dyspepsia / Q000188:drug therapy* / Q000276:immunology; D018836:Inflammation Mediators / Q000378:metabolism; D009980:Influenza A virus / Q000472:pathogenicity*; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000473:pathology / Q000821:virology; D008297:Male; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000821:virology; D013270:Stomach / Q000187:drug effects* / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D016207:Cytokines; D004365:Drugs, Chinese Herbal; D018836:Inflammation Mediators; C586196:yin lai tang