title: The effect of safflower yellow on spinal cord ischemia reperfusion injury in rabbits.
abstract: Safflower yellow (SY) is the safflower extract and is the one of traditional Chinese medicine. The aim of the present work was to investigate the effect of SY on spinal cord ischemia reperfusion injury (SCIRI) in rabbits. The models of spinal cord ischemia reperfusion (SI/R) were constructed, and the degree of the post-ischemic injury was assessed by means of the neurological deficit scores and plasma levels of lipid peroxidation reactioin and neuronal morphologic changes. SCIRI remarkably affected the functional activities of the hind limbs and activated lipid peroxidation reaction. SY could attenuate apoptosis and SCIRI by enhancing Bcl-2 expression and inhibiting Bax and caspase-3 activation.
authors.affiliation: Department of Anesthesiology, Guangdong No. 2 Provincial People's Hospital, Guangdong Provincial Emergency Hospital, Guangzhou, Guangdong Province 0086 510317, China.
authors.forename: Daiwei
authors.initials: D
authors.lastname: Zhou
authors.affiliation: Department of Anesthesiology, Guangdong No. 2 Provincial People's Hospital, Guangdong Provincial Emergency Hospital, Guangzhou, Guangdong Province 0086 510317, China.
authors.forename: Bingbing
authors.initials: B
authors.lastname: Liu
authors.affiliation: Department of Anesthesiology, Guangdong No. 2 Provincial People's Hospital, Guangdong Provincial Emergency Hospital, Guangzhou, Guangdong Province 0086 510317, China.
authors.forename: Xiaoshan
authors.initials: X
authors.lastname: Xiao
authors.affiliation: Department of Anesthesiology, Foshan First People's Hospital, Guangdong Province 0086 510317, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Dai
authors.affiliation: Department of Anesthesiology, Guangdong No. 2 Provincial People's Hospital, Guangdong Provincial Emergency Hospital, Guangzhou, Guangdong Province 0086 510317, China.
authors.forename: Songmei
authors.initials: S
authors.lastname: Ma
authors.affiliation: Department of Anesthesiology, Guangdong No. 2 Provincial People's Hospital, Guangdong Provincial Emergency Hospital, Guangzhou, Guangdong Province 0086 510317, China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Huang
mesh_terms: D000818:Animals; D000870:Anterior Horn Cells / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D048430:Cell Shape / Q000187:drug effects; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D006614:Hindlimb / Q000187:drug effects / Q000503:physiopathology; D020287:In Situ Nick-End Labeling; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008517:Phytotherapy; D011817:Rabbits; D015427:Reperfusion Injury / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000201:enzymology; D020760:Spinal Cord Ischemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy* / Q000201:enzymology; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D055986:Vital Signs / Q000187:drug effects; D051028:bcl-2-Associated X Protein / Q000378:metabolism
chemical_list: D016209:Interleukin-8; D051028:bcl-2-Associated X Protein; C076422:safflower yellow; D008315:Malondialdehyde; D002599:Chalcone; D013482:Superoxide Dismutase; D053148:Caspase 3