title: [Radiation therapy for pleomorphic adenoma of the parotid].
abstract: Parotid pleomorphic adenoma is the most frequent tumor of salivary glands. The prognosis depends on the recurrences because they could lead to iatrogenic events (facial paralysis). Moreover the risk of malignant transformation increases with the number of local relapses. This article aims at reviewing histological and radiological criteria and the surgical techniques. To improve local control, adjuvant irradiation (in first intention or after recurrence) may be useful but is still controversial for benign tumors in young patients with a risk of radio-induced cancer. We listed studies in which adjuvant radiotherapy was used so as to define its place in the treatment strategy. Prognostic factors were found by some authors. Other studies have to be done before strong evidence-based recommendations are issued.
authors.affiliation: Service d'oncologie radiothérapie, PRC, CHU de Poitiers, 2, rue de la Milétrie, BP577, 86021 Poitiers, France.
authors.forename: P
authors.initials: P
authors.lastname: Jardel
authors.affiliation: Service d'ORL et chirurgie cervicofaciale, hôpital de La Timone Adultes, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.
authors.forename: N
authors.initials: N
authors.lastname: Fakhry
authors.affiliation: Département d'ORL et chirurgie cervicofaciale, hôpital Gui-de-Chauliac, CHRU de Montpellier, 34295 Montpellier cedex 5, France.
authors.forename: M
authors.initials: M
authors.lastname: Makeieff
authors.affiliation: Service d'imagerie médicale, CHU de Poitiers, 2, rue de la Milétrie, BP577, 86021 Poitiers, France.
authors.forename: J-C
authors.initials: JC
authors.lastname: Ferrie
authors.affiliation: Service de cytologie et d'anatomie pathologiques, CHU de Poitiers, 2, rue de la Milétrie, BP577, 86021 Poitiers, France.
authors.forename: S
authors.initials: S
authors.lastname: Milin
authors.affiliation: Clinique universitaire d'ORL, pôle tête et cou et chirurgie réparatrice, CHU de Grenoble, boulevard de la Chantourne, 38700 La Tronche, France.
authors.forename: C
authors.initials: C
authors.lastname: Righini
authors.affiliation: Service d'imagerie, clinique du Pont-Rouge, 15000 Aurillac, France.
authors.forename: A
authors.initials: A
authors.lastname: Lacout
authors.affiliation: Service d'anatomie et cytologie pathologiques, hôpital Gui-de-Chauliac, CHRU de Montpellier, 34295 Montpellier cedex 5, France.
authors.forename: V
authors.initials: V
authors.lastname: Costes
authors.affiliation: Service d'ORL et chirurgie cervicofaciale, CHU de Nantes, 1, place Alexis-Ricordeau, 44093 Nantes, France.
authors.forename: O
authors.initials: O
authors.lastname: Malard
authors.affiliation: Service d'imagerie, centre François-Baclesse, 3, avenue du Général-Harris, 14000 Caen, France.
authors.forename: P-Y
authors.initials: PY
authors.lastname: Marcy
authors.affiliation: Service d'ORL et chirurgie cervicofaciale, institut universitaire de la face et du cou, 33, avenue Valombrose, 06189 Nice, France.
authors.forename: N
authors.initials: N
authors.lastname: Guevara
authors.affiliation: Service d'oncologie radiothérapie, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice, France; Institut universitaire de la face et du cou, 33, avenue Valombrose, 06189 Nice, France; Université Nice-Sophia-Antipolis, 33, avenue Valombrose, 06189 Nice, France.
authors.forename: G
authors.initials: G
authors.lastname: Odin
authors.affiliation: Service d'oncologie radiothérapie, PRC, CHU de Poitiers, 2, rue de la Milétrie, BP577, 86021 Poitiers, France.
authors.forename: R-J
authors.initials: RJ
authors.lastname: Bensadoun
authors.affiliation: Service d'oncologie radiothérapie, centre Antoine-Lacassagne, 33, avenue Valombrose, 06189 Nice, France; Institut universitaire de la face et du cou, 33, avenue Valombrose, 06189 Nice, France; Université Nice-Sophia-Antipolis, 33, avenue Valombrose, 06189 Nice, France. Electronic address: jthariat@hotmail.com.
authors.forename: J
authors.initials: J
authors.lastname: Thariat
mesh_terms: D008949:Adenoma, Pleomorphic / Q000175:diagnosis / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery; D000367:Age Factors; D020220:Facial Nerve Injuries / Q000517:prevention & control; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control; D059351:Organ Sparing Treatments; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000532:radiotherapy* / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D011379:Prognosis; D011832:Radiation Injuries / Q000517:prevention & control; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant
keywords: Adulte jeune; Adénome pléomorphe; Cancer radio-induit; Chirurgie; Facial palsy; Paralysie faciale; Pleomorphic adenoma; Radiation therapy; Radio-induced cancer; Radiothérapie; Recurrence; Récidive; Tumeur mixte; Young adults