title: [Immunotherapy and hyperthermia for the treatment of patients with advanced or recurrent colorectal cancer].
abstract: We treated 226 patients with advanced or recurrent colorectal cancer using hyperthermia or immunotherapy between July 2005 and September 2012. Clinical benefit (complete response [CR], partial response [PR], and long stable disease [SD] for more than 6 months) was observed in 30 patients (13.3%), including CR in 5 patients. The effective rate of immunotherapy increased from 14.3% to 16.1% using hyperthermia. The effective rate of hyperthermia was 3.9%. Of the 30 effectively treated patients, liver metastases disappeared in 2 patients treated with hyperthermia alone, and lung metastases disappeared in 2 patients treated with immunotherapy alone. In the remaining 26 effectively treated patients, multiple metastases were observed in solid organs. Both hyperthermia and immunotherapy were administered and were found to be effective in the treatment of patients with advanced or recurrent colorectal cancer.
authors.affiliation: Osaka Cancer Immuno-Chemotherapy Center.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takeda
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Akita
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeda
authors.forename: Kana
authors.initials: K
authors.lastname: Nakamura
authors.forename: Shogo
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Takeda
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D003713:Dendritic Cells / Q000276:immunology; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012008:Recurrence