title: Asymmetric reduction of diynones and the total synthesis of (S)-panaxjapyne A.
abstract: The asymmetric transfer hydrogenation of a series of diynones has been achieved in high conversion and enantiomeric induction. When R(1) is a phenyl group, a competing alkyne reduction takes place; however, when R(1) is an alkyl group, this side-reaction is not observed. The application of the reduction to the total synthesis of the natural product (S)-panaxjapyne A in high enantiomeric excess is described.
authors.affiliation: Department of Chemistry, The University of Warwick , Coventry, CV4 7AL, U.K.
authors.forename: Zhijia
authors.initials: Z
authors.lastname: Fang
authors.forename: Martin
authors.initials: M
authors.lastname: Wills
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D053279:Polyynes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; C552292:panaxjapyne A; D053279:Polyynes