title: BAIAP2 exhibits association to childhood ADHD especially predominantly inattentive subtype in Chinese Han subjects.
abstract: BACKGROUND
  Attention-deficit/hyperactivity disorder (ADHD) is a common chronic neurodevelopmental disorder with a high heritability. Much evidence of hemisphere asymmetry has been found for ADHD probands from behavioral level, electrophysiological level and brain morphology. One previous research has reported possible association between BAIAP2, which is asymmetrically expressed in the two cerebral hemispheres, with ADHD in European population. The present study aimed to investigate the association between BAIAP2 and ADHD in Chinese Han subjects.
  
  
  METHODS
  A total of 1,397 ADHD trios comprised of one ADHD proband and their parents were included for family-based association tests. Independent 569 ADHD cases and 957 normal controls were included for case-control studies. Diagnosis was performed according to the DSM-IV criteria. Nine single nucleotide polymorphisms (SNPs) of BAIAP2 were chosen and performed genotyping for both family-based and case-control association studies.
  
  
  RESULTS
  Transmission disequilibrium tests (TDTs) for family-based association studies showed significant association between the CA haplotype comprised by rs3934492 and rs9901648 with predominantly inattentive type (ADHD-I). For case-control study, chi-square tests provided evidence for the contribution of SNP rs4969239, rs3934492 and rs4969385 to ADHD and its two clinical subtypes, ADHD-I and ADHD-C. However, only the associations for ADHD and ADHD-I retained significant after corrections for multiplicity or logistic regression analyses adjusting the potential confounding effect of gender and age.
  
  
  CONCLUSIONS
  These above results indicated the possible involvement of BAIAP2 in the etiology of ADHD, especially ADHD-I.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Ze-Hua
authors.initials: ZH
authors.lastname: Li
authors.forename: Hai-Mei
authors.initials: HM
authors.lastname: Li
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Wei
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Peking University Sixth Hospital/Institute of Mental Health, Beijing 100191, China. qianqiujin@bjmu.edu.cn.
authors.forename: Qiu-Jin
authors.initials: QJ
authors.lastname: Qian
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics* / Q000706:statistics & numerical data*; D001289:Attention Deficit Disorder with Hyperactivity / Q000208:ethnology* / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D007839:Functional Laterality / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: C119539:BAIAP2 protein, human; D005819:Genetic Markers; D009419:Nerve Tissue Proteins