title: Co-localization of L-type voltage dependent calcium channel alpha 1D subunit (Ca(v)1.3) and calbindin (CB) in the mouse central nervous system.
abstract: Previous study has shown that the co-localization of calbindin (CB) with L-type voltage dependent Ca(2+) channel (VDCC) alpha 1C subunit (Ca(v)1.2) in the rat insulinoma 1046-38 (RIN) beta cells may play an important regulatory role in Ca(2+) influx and exocytosis of insulin granules. In the present study, L-type voltage dependent Ca(2+) channel (VDCC) and calbindin (CB) were demonstrated in different regions of the mouse central nervous system (CNS). Double labeling immunofluorescence staining showed a co-localization of Ca(v)1.3 and CB. The co-localization of Ca(v)1.3 and CB in certain brain regions such as the hippocampus suggests their important roles in neuroplasticity. The relative high percentages of co-localization of Ca(v)1.3 with CB in the laminae II of the dorsal horn of the spinal cord indicate that the regulation mechanism of nociceptive transmission may be related with both VDCC and Ca(2+) binding protein.
authors.affiliation: Department of Anatomy and Histology, Xi'an Jiaotong University College of Medicine, Xi'an 710061, People's Republic of China.
authors.forename: Jie Hua
authors.initials: JH
authors.lastname: Xu
authors.affiliation: Department of Orthopedics, The First Hospital of Yulin, Yulin 71900, People's Republic of China.
authors.forename: Zhen Bang
authors.initials: ZB
authors.lastname: Yang
authors.affiliation: Department of Anatomy and Histology, Xi'an Jiaotong University College of Medicine, Xi'an 710061, People's Republic of China; Center for Human Assisted Reproduction, Maternity and Child Healthcare Hospital of Shaanxi Province, Xi'an, Shaanxi 710003, People's Republic of China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Temasek Laboratories, National University of Singapore, Singapore, Singapore; Medical School of Yangtze University, People's Republic of China. Electronic address: tangfr@gmail.com.
authors.forename: Feng-Ru
authors.initials: FR
authors.lastname: Tang
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D064026:Calbindins / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: C485995:Cacna1d protein, mouse; D064026:Calbindins; D020746:Calcium Channels, L-Type
keywords: CB; Ca(v)1.3; Central nervous system; Co-localization