title: [Simultaneous determination of 11 quinolones in hotpot ingredients by dispersive solid-phase extraction and ultra performance liquid chromatography-tandem mass spectrometry].
abstract: A method for the simultaneous determination of the residues of 11 quinolones in hotpot ingredients by quick, easy, cheap, effective, rugged and safe (QuEChERS) extraction and ultra performance liquid chromatography-tandem mass spectrometric method (UPLC-MS/MS) was established. The sample was extracted with acetonitrile (containing 5% formic acid) and followed by stratifying with a salting-out agent. Clean-up of the extracts was processed by C18 and PSA, a modified QuEChERS procedure. The analytes were then separated on a Poroshell 120 EC-C18 column, and finally detected by tandem mass spectrometry in positive ESI mode. The linearity of all the 11 quinolones in the range from 1.0 to 100.0 microg/kg had correlation coefficients greater than 0.998. The limits of detection (LOD) of the method were from 1.8 to 3.1 microg/kg and the limits of quantification (LOQ) were from 6.0 to 10.3 microg/kg. The average recoveries of the 11 quinolones were in the range from 70.1% to 100.3%, with relative standard deviations from 2.42% to 10.88%. The established method is sensitive and of good recoveries. It can be applied as a rapid and reliable method for the determination of the 11 quinolones in hotpot ingredients.
authors.affiliation: Yantai Entry-Exit Inspection and Quarantine Bureau, Yantai 264000, China. sdytcp@163.com
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.affiliation: Yantai Entry-Exit Inspection and Quarantine Bureau, Yantai 264000, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Mou
authors.affiliation: Qingdao Entry-Exit Inspection and Quarantine Bureau, Qingdao 266000, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.affiliation: Yantai Entry-Exit Inspection and Quarantine Bureau, Yantai 264000, China.
authors.forename: Jinpei
authors.initials: J
authors.lastname: Geng
authors.affiliation: Yantai Jieke Inspection Service Co., Ltd., Laiyang 265231, China.
authors.forename: Xiqing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Yantai Entry-Exit Inspection and Quarantine Bureau, Yantai 264000, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Sui
authors.affiliation: Yantai Entry-Exit Inspection and Quarantine Bureau, Yantai 264000, China.
authors.forename: Junni
authors.initials: J
authors.lastname: Liang
authors.affiliation: Yantai Entry-Exit Inspection and Quarantine Bureau, Yantai 264000, China.
authors.forename: Meilan
authors.initials: M
authors.lastname: Sha
authors.affiliation: Yantai Entry-Exit Inspection and Quarantine Bureau, Yantai 264000, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Guan
mesh_terms: D002851:Chromatography, High Pressure Liquid; D005506:Food Contamination / Q000032:analysis*; D057230:Limit of Detection; D015363:Quinolones / Q000032:analysis*; D052616:Solid Phase Extraction; D053719:Tandem Mass Spectrometry
chemical_list: D015363:Quinolones