title: Primary sclerosing cholangitis and its relationship to the colon in a black cohort of inflammatory bowel disease patients.
abstract: BACKGROUND
  Recent studies have identified subgroups of inflammatory bowel disease (IBD) patients at increased likelihood for developing primary sclerosing cholangitis (PSC). Most studies look at predominantly white populations.
  
  
  OBJECTIVE
  The aim of our study was to determine the characteristics of PSC in a black cohort of patients and its relationship to disease location in IBD.
  
  
  METHODS
  A retrospective analysis was performed on IBD patients over the age of 18 years.
  
  
  RESULTS
  Of the 209 black patients identified as having IBD, 7 (3.5%) had a concomitant diagnosis of PSC; 5/138 (3.6%) ulcerative colitis (UC) patients, and 2/71 (2.8%) Crohn's disease patients (CD). Numerically, more males developed PSC in both the UC and CD subgroups. Age at diagnosis of IBD tended to be younger among PSC cohorts. All PSC-UC patients had pancolitis (P<0.0001), and all PSC-CD patients had a colonic component to their disease. In the UC cohort, PSC patients were statistically more likely to be on immunosuppressive therapy (P<0.0001).
  
  
  CONCLUSIONS
  With greater research, physicians will better recognize IBD phenotypes at highest risk of PSC and hopefully identify complications of PSC, including cholangiocarcinoma.
authors.affiliation: *Department of Gastroenterology, SUNY Downstate Medical Center †Department of Gastroenterology, Brooklyn Campus of the VA NY Harbor Healthcare System, Brooklyn ‡Department of Rheumatology, Columbia Presbyterian Medical Center, New York, NY.
authors.forename: Charles P
authors.initials: CP
authors.lastname: Koczka
authors.forename: Laura B
authors.initials: LB
authors.lastname: Geraldino-Pardilla
authors.forename: Garrett
authors.initials: G
authors.lastname: Lawlor
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001741:Black or African American; D017668:Age of Onset; D015209:Cholangitis, Sclerosing / Q000175:diagnosis / Q000208:ethnology*; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000208:ethnology*; D003424:Crohn Disease / Q000208:ethnology*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D007155:Immunologic Factors