title: HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan.
abstract: The human leukocyte antigen (HLA) system has a major role in the regulation of the immune response as it is involved in the defense against pathogens. Some studies have reported that HLA class II genes play a strong role in severe cases of pulmonary tuberculosis (PTB) in several populations. Thus the aim of the study was to compare the HLA-class II alleles of patients with drug resistant tuberculosis with those of healthy controls from the same ethnic group in Kazakhstan. The aim of the present study was to evaluate the correlation of HLA-class II alleles by patients with drug resistant tuberculosis and the healthy controls of the same ethnic group in Kazakhstan. The HLA-class II alleles of 76 patients with tuberculosis (TB) and 157 healthy volunteers were investigated using sequence-based typing (SBT)-method. HLA-DQA1*03:02 HLA-DRB1*08:01 and DRB1*08:03 occurred more frequently (P = 0.05) in patients with drug resistant tuberculosis than in controls. We observed a possible association between certain HLA alleles and TB that are specific for the Kazakh population. Further studies are needed to confirm our findings using a larger number of patients with drug resistant tuberculosis.
authors.affiliation: National Center for Biotechnology, Astana, Kazakhstan.
authors.forename: A B
authors.initials: AB
authors.lastname: Kuranov
authors.forename: U A
authors.initials: UA
authors.lastname: Kozhamkulov
authors.forename: M N
authors.initials: MN
authors.lastname: Vavilov
authors.forename: E S
authors.initials: ES
authors.lastname: Belova
authors.forename: V L
authors.initials: VL
authors.lastname: Bismilda
authors.forename: A H
authors.initials: AH
authors.lastname: Alenova
authors.forename: S S
authors.initials: SS
authors.lastname: Ismailov
authors.forename: K T
authors.initials: KT
authors.lastname: Momynaliev
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D059848:HLA-DQ alpha-Chains / Q000145:classification / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains / Q000145:classification / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D007623:Kazakhstan; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000276:immunology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D059811:HLA-DRB1 Chains
keywords: Kazakhstan; human leukocyte antigen; tuberculosis