title: Antidyslipidemic and Antioxidant Activities of Hibiscus rosa sinensis Root Extract in Alloxan Induced Diabetic Rats.
abstract: The antidyslipidemic activity of Hibiscus rosa sinensis (Malvaceae) root extract has been studied in alloxan induced diabetic rats. In this model, oral administration of root extract (500 mg/kg bw. p.o.) for 15 days resulted in significant decreased in the levels of blood glucose, plasma lipids and reactivated post heparin lipoprotein lipase activity in alloxan induced diabetic rats. Furthermore, the root extract (50-500 μg) when tested for its antioxidant activity, inhibited the generation of super oxide anions and hydroxyl radicals, in both enzymic and non enzymic systems in vitro. The results of the present study demonstrated antidyslipidemic and antioxidant activities in root extract of H. rosa sinensis which could be used in prevention of diabetic-dyslipidemia and related complications.
authors.affiliation: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Sarfarazganj, Hardoi Road, Lucknow, 226003 India.
authors.forename: Vishnu
authors.initials: V
authors.lastname: Kumar
authors.affiliation: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Sarfarazganj, Hardoi Road, Lucknow, 226003 India.
authors.forename: Farzana
authors.initials: F
authors.lastname: Mahdi
authors.affiliation: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Khanna
authors.affiliation: Department of Biochemistry, C.S.M. Medical University, Lucknow, India.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, Era's Lucknow Medical College & Hospital, Sarfarazganj, Hardoi Road, Lucknow, 226003 India.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Chander
authors.affiliation: Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: Jitendra Kumar
authors.initials: JK
authors.lastname: Saxena
authors.affiliation: Department of Biochemistry, C.S.M. Medical University, Lucknow, India.
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Mahdi
authors.affiliation: Department of Biochemistry, Shri Guru Ram Rai Institute of Medical & Health Sciences, Dehradun, India.
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Singh
keywords: Alloxan induced-diabetes; Anti-dyslipidemic agent; Hibiscus rosa sinensis; Hypoglycemic agent; Natural antioxidants; Post heparin lipolytic activity