title: Chlorogenic acid-phospholipid complex improve protection against UVA induced oxidative stress.
abstract: The mammalian skin is prone to oxidative damage when exposed to ultraviolet (UV) rays from the sun light. The antioxidants like chlorogenic acid (CA) can protect the skin from the ill effects of UV radiation when applied topically. But conventional topical formulations of these phytomolecules could not protect the skin for long duration owing to their rapid distribution in the systemic circulation. Therefore the aim of the present investigation was to prepare a novel topical formulation of CA which can exert its protective effect for long time after its application. The phospholipid complex of the CA was prepared and evaluated against oxidative stress produced in the rat skin due to UVA exposure. Compared to the conventional formulation, the complex exerted improved protection when UVA irradiation was performed after 4h of topical application. Thus the results ascertain the superiority of CA-phospholipid complex over conventional formulation in terms of protection against UVA radiation for long duration.
authors.affiliation: School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address: souvikool@gmail.com.
authors.forename: Sauvik
authors.initials: S
authors.lastname: Bhattacharyya
authors.affiliation: School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address: soma.ncpt@gmail.com.
authors.forename: Soma
authors.initials: S
authors.lastname: Majhi
authors.affiliation: School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address: drbpsaha@yahoo.com.
authors.forename: Bishnu Pada
authors.initials: BP
authors.lastname: Saha
authors.affiliation: School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address: naturalproductm@gmail.com.
authors.forename: Pulok K
authors.initials: PK
authors.lastname: Mukherjee
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D002726:Chlorogenic Acid / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D010743:Phospholipids / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D012869:Skin Absorption; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D010743:Phospholipids; D011837:Radiation-Protective Agents; D017392:Thiobarbituric Acid Reactive Substances; D002726:Chlorogenic Acid; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Chlorogenic acid; Phospholipid complex; Skin; Topical delivery; UVA irradiation