title: Impact of Clinical and Histo-Pathological Prognostic Factors on T1-2N0-1 Oral Tongue Carcinoma.
abstract: To determine predictive factors which affect local and regional recurrence of T1-2N0-1M0 oral tongue carcinoma (OTC). Records of 42 patients with T1-2N0-1 M0 OTC were reviewed. The clinical characteristics, histo-pathological data, disease recurrence and survival rate were analyzed. Descriptive statistics and Kaplan-Meier survival analysis were used. The median follow up was 38 months. The 2-year overall survival and disease-free survival rates were 85.7 and 55.6 % respectively. At the 2 year analysis, there were surgical margin <5 mm (p value = 0.01), tumor thickness >7 mm (p value = 0.03), perivascular and perilymphatic invasion (p value = 0.01) affected on local recurrence and perivascular and perilymphatic invasion were also predictors for regional recurrence (p value = 0.04). The surgical margin status, tumor thickness, perivascular and perilymphatic invasion represented significant predictive factors for local recurrent OTC. Postoperative adjuvant therapy should be considered in these groups.
authors.affiliation: Head and Neck Surgery Unit, Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Pichit
authors.initials: P
authors.lastname: Sittitrai
authors.affiliation: Head and Neck Surgery Unit, Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Chonticha
authors.initials: C
authors.lastname: Srivanitchapoom
authors.affiliation: Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Pongsak
authors.initials: P
authors.lastname: Mahanupab
authors.affiliation: Head and Neck Surgery Unit, Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Thienchai
authors.initials: T
authors.lastname: Pattarasakulchai
authors.affiliation: Head and Neck Surgery Unit, Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Rak
authors.initials: R
authors.lastname: Tananuvat
authors.affiliation: Head and Neck Surgery Unit, Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Warat
authors.initials: W
authors.lastname: Unejanum
keywords: Clinical prognostic factor; Early stage; Histo-pathological prognostic factor; Tongue carcinoma