title: Prognostic value of CtIP/RBBP8 expression in breast cancer.
abstract: CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination and the G1 and G2 checkpoints. Its multiple roles are controlled by its interaction with several specific factors, including the tumor suppressor proteins BRCA1 and retinoblastoma. Both its functions and interactors point to a putative oncogenic potential of CtIP/RBBP8 loss. However, CtIP/RBBP8 relevance in breast tumor appearance, development, and prognosis has yet to be established. We performed a retrospective analysis of CtIP/RBBP8 and RB1 levels by immunohistochemistry using 384 paraffin-embedded breast cancer biopsies obtained during tumor removal surgery. We have observed that low or no expression of CtIP/RBBP8 correlates with high-grade breast cancer and with nodal metastasis. Reduction on CtIP/RBBP8 is most common in hormone receptor (HR)-negative, HER2-positive, and basal-like tumors. We observed lower levels of RB1 on those tumors with reduced CtIP/RBBP8 levels. On luminal tumors, decreased but not absence of CtIP/RBBP8 levels correlate with increased disease-free survival when treated with a combination of hormone, radio, and chemo therapies.
authors.affiliation: Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Av. Americo Vespucio s/n, Sevilla, 41092, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Soria-Bretones
authors.forename: Carmen
authors.initials: C
authors.lastname: Sáez
authors.forename: Manuel
authors.initials: M
authors.lastname: Ruíz-Borrego
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Japón
authors.forename: Pablo
authors.initials: P
authors.lastname: Huertas
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D004706:Endodeoxyribonucleases; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000378:metabolism*; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D004706:Endodeoxyribonucleases; D019394:Ki-67 Antigen; D009687:Nuclear Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D016160:Retinoblastoma Protein; C508053:ERBB2 protein, human; C410741:RBBP8 protein, human
keywords: Breast cancer; CtIP/RBBP8; DNA repair; retinoblastoma