title: [Recent progress on SELEX and its applications].
abstract: SELEX technology (Systematic Evolution of Ligand by Exponential Enrichment) is a new in vitro screening technology appeared and developed in the past 20 years. SELEX integrate library technology and screening techniques, screening a nucleic acid molecule from nucleic acid library by ligand-aptamer interaction. Similar to the antibodies, aptamers bind with the specific target substance. SELEX screening technology develops rapidly, and aptamer have been widely applied in biomedical field. This article briefly-overviewed the progress and its applications of SELEX technology in recent years.
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China. zhanboyang@sina.com
authors.forename: Shao-bing
authors.initials: SB
authors.lastname: Zhan
authors.affiliation: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100052, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D000818:Animals; D015723:Gene Library; D006801:Humans; D009841:Oligonucleotides / Q000235:genetics*; D052156:SELEX Aptamer Technique / Q000379:methods*
chemical_list: D009841:Oligonucleotides