title: Novel inhibitors of the Plasmodium falciparum electron transport chain.
abstract: Due to an increased need for new antimalarial chemotherapies that show potency against Plasmodium falciparum, researchers are targeting new processes within the parasite in an effort to circumvent or delay the onset of drug resistance. One such promising area for antimalarial drug development has been the parasite mitochondrial electron transport chain (ETC). Efforts have been focused on targeting key processes along the parasite ETC specifically the dihydroorotate dehydrogenase (DHOD) enzyme, the cytochrome bc 1 enzyme and the NADH type II oxidoreductase (PfNDH2) pathway. This review summarizes the most recent efforts in antimalarial drug development reported in the literature and describes the evolution of these compounds.
authors.affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
authors.forename: P A
authors.initials: PA
authors.lastname: Stocks
authors.affiliation: Department of Chemistry, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, UK.
authors.forename: V
authors.initials: V
authors.lastname: Barton
authors.affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
authors.forename: T
authors.initials: T
authors.lastname: Antoine
authors.affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
authors.forename: G A
authors.initials: GA
authors.lastname: Biagini
authors.affiliation: Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Ward
authors.affiliation: Department of Chemistry, University of Liverpool, P.O. Box 147, Liverpool, L69 3BX, UK.
authors.forename: P M
authors.initials: PM
authors.lastname: O'Neill
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D000090722:Dihydroorotate Dehydrogenase; D004579:Electron Transport / Q000187:drug effects*; D014450:Electron Transport Complex III / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology; D062105:Molecular Docking Simulation; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000201:enzymology; D015800:Protozoan Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D000090722:Dihydroorotate Dehydrogenase; D004791:Enzyme Inhibitors; D015800:Protozoan Proteins; D044925:Oxidoreductases Acting on CH-CH Group Donors; D009247:NADH, NADPH Oxidoreductases; D014450:Electron Transport Complex III