title: Highly N2-selective coupling of 1,2,3-triazoles with indole and pyrrole.
abstract: Hydrogen-bond mediated coupling of 1,2,3-triazoles to indoles and pyrroles results in N2 selective functionalization of the triazole moiety in moderate to excellent yields. The reaction was tolerant of un-, mono- and disubstituted triazoles and was applied to synthesize tryptophan derived fluorescent amino acids.
authors.affiliation: Department of Chemistry, Renmin University of China, 59 Zhongguanchun street, Haidian District, Beijing 100872 (P. R. China), Fax: (+86) 10-62516660.
authors.forename: Jian
authors.initials: J
authors.lastname: Wen
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Zhu
authors.forename: Qing-Wei
authors.initials: QW
authors.lastname: Bi
authors.forename: Zhu-Qing
authors.initials: ZQ
authors.lastname: Shen
authors.forename: Xiao-Xiao
authors.initials: XX
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Zili
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis; D002384:Catalysis; D054879:Halogenation; D007211:Indoles / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D007211:Indoles; D011758:Pyrroles; D014230:Triazoles; C030374:indole
keywords: 1,2,3-triazole; heterocycles; indole-triazole conjugates; iodination mediated reaction; pyrrole-triazole conjugates; regioselectivity