title: UDP-glucuronosyltransferase promoter polymorphism in Iranian neonates with idiopathic hyperbilirubinemia.
abstract: To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) less than 15mg/dl enrolled in this study. Thymine-adenine (TA)  repeats in the promoter region of UGT1A1 gene investigated by means of  polymerase- chain reaction (PCR) DNA sequencing. Demographic characteristics did not differ significantly between groups while STB was higher in case group (17.5±1.9 vs. 10.4±1.8, p value<0.001). Among one hundred neonates evaluated in this study, TA6/6, TA6/7 and TA7/7 genotypes found in 52%, 42% and 6%, totally. TA6/7 and TA7/7 genotypes observed in case group more than the control group (P<0.001). STB levels were significantly higher in cases with TA6/7 and TA7/7 genotype pattern (P<0.001). Heterozygous and variant homozygous genotypes of the promoter region of UGT1A1 gene in healthy Iranian neonates with idiopathic hyperbilirubinemia should be considered.
authors.affiliation: Department of Neonatology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. pedkaveh2000@yahoo.com.
authors.forename: Mahbod
authors.initials: M
authors.lastname: Kaveh
authors.forename: Tahereh
authors.initials: T
authors.lastname: Esmailnia
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Nayeri
authors.forename: Firoozeh
authors.initials: F
authors.lastname: Nili
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Davari Tanha
authors.forename: Mahsa
authors.initials: M
authors.lastname: Ghajarzdeh
mesh_terms: D005260:Female; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D006932:Hyperbilirubinemia / Q000235:genetics*; D007231:Infant, Newborn; D007492:Iran; D008297:Male; D011401:Promoter Regions, Genetic; D000099148:UGT1A1 Enzyme
chemical_list: D014453:Glucuronosyltransferase; D000099148:UGT1A1 Enzyme