title: How we manage the haematological aspects of major obstetric haemorrhage.
abstract: Major obstetric haemorrhage (MOH) remains an important medical challenge worldwide, contributing to significant maternal morbidity and mortality. Prompt and appropriate management is essential if we are to improve outcomes and reduce substandard care that may result in adverse consequences. This review describes the current understanding of the pathophysiological aspects of MOH together with the principles of transfusion and haemostatic therapy, with emphasis on a coordinated multidisciplinary approach. We also highlight the current lack of evidence available from randomized controlled trials to inform best practice and the need to prioritize research in this key clinical area.
authors.affiliation: Barts Health NHS Trust & NHS Blood and Transplant, London, UK.
authors.forename: Shubha
authors.initials: S
authors.lastname: Allard
authors.forename: Laura
authors.initials: L
authors.lastname: Green
authors.forename: Beverley J
authors.initials: BJ
authors.lastname: Hunt
mesh_terms: D001777:Blood Coagulation; D019033:Delivery of Health Care, Integrated; D004909:Erythrocyte Indices; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006473:Postpartum Hemorrhage / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D011247:Pregnancy; D012307:Risk Factors; D013916:Thrombelastography
chemical_list: D006454:Hemoglobins
keywords: haemorrhage; pregnancy; transfusion