title: Pathogenic and therapeutic role of miRNAs in breast cancer.
abstract: MicroRNAs (miRNAs) are small noncoding RNA molecules present in all cell types, with sizes that vary from 18 to 28 nucleotides. miRNAs play significant roles in several biological processes, including development, differentiation, metabolism, initiation, and progression of cancer. In recent years, considerable research has been directed towards identifying miRNAs in peripheral blood from circulating tumor cells and disseminating tumor cells. Because these circulatory miRNAs are very stable and reproducible, their identification could be useful as prognostic markers as well as therapeutic agents for many cancers such as breast cancer. In this article, we review the role of specific circulatory miRNAs in breast cancer, with particular emphasis on their clinical importance.
authors.affiliation: Center of Excellence in Cancer Research, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University, Health Sciences Center, El Paso, TX 79905.
authors.forename: Vittal Venkatasatya
authors.initials: VV
authors.lastname: Kurisetty
authors.affiliation: Center of Excellence in Cancer Research, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University, Health Sciences Center, El Paso, TX 79905.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Lakshmanaswamy
authors.affiliation: Center of Excellence in Cancer Research, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University, Health Sciences Center, El Paso, TX 79905.
authors.forename: Chendil
authors.initials: C
authors.lastname: Damodaran
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics / Q000502:physiology*
chemical_list: D035683:MicroRNAs