title: Acyl-homoserine lactone quorum sensing in the Roseobacter clade.
abstract: Members of the Roseobacter clade are ecologically important and numerically abundant in coastal environments and can associate with marine invertebrates and nutrient-rich marine snow or organic particles, on which quorum sensing (QS) may play an important role. In this review, we summarize current research progress on roseobacterial acyl-homoserine lactone-based QS, particularly focusing on three relatively well-studied representatives, Phaeobacter inhibens DSM17395, the marine sponge symbiont Ruegeria sp. KLH11 and the dinoflagellate symbiont Dinoroseobacter shibae. Bioinformatic survey of luxI homologues revealed that over 80% of available roseobacterial genomes encode at least one luxI homologue, reflecting the significance of QS controlled regulatory pathways in adapting to the relevant marine environments. We also discuss several areas that warrant further investigation, including studies on the ecological role of these diverse QS pathways in natural environments.
authors.affiliation: Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Science, 701 E Pratt St., Baltimore, MD 21202, USA. jzan@wisc.edu.
authors.forename: Jindong
authors.initials: J
authors.lastname: Zan
authors.affiliation: Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Science, 701 E Pratt St., Baltimore, MD 21202, USA. yliu@chem.wisc.edu.
authors.forename: Yue
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Science, 701 E Pratt St., Baltimore, MD 21202, USA. cfuqua@indiana.edu.
authors.forename: Clay
authors.initials: C
authors.lastname: Fuqua
authors.affiliation: Institute of Marine and Environmental Technology, University of Maryland Center for Environmental Science, 701 E Pratt St., Baltimore, MD 21202, USA. hill@umces.edu.
authors.forename: Russell T
authors.initials: RT
authors.lastname: Hill
mesh_terms: D054742:Acyl-Butyrolactones / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D019295:Computational Biology; D004141:Dinoflagellida / Q000502:physiology; D011161:Porifera / Q000502:physiology; D053038:Quorum Sensing; D012097:Repressor Proteins / Q000378:metabolism; D041904:Roseobacter / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D054742:Acyl-Butyrolactones; D001426:Bacterial Proteins; C085427:LuxI protein, Bacteria; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D037521:Virulence Factors; C064778:LuxR autoinducer binding proteins