title: Comparison of mastectomy with breast-conserving surgery in invasive lobular carcinoma: 15-Year results.
abstract: BACKGROUND
  Invasive lobular cancer (ILC) is biologically distinct from invasive ductal cancer and there is disagreement regarding appropriate local management of this disease.
  
  
  OBJECTIVE
  The current study reports long term results comparing mastectomy with breast-conserving surgery (BCS) in the treatment of ILC.
  
  
  METHODS
  Study includes 235 women with ILC treated between 1983 and 1987. All of them underwent axillary dissection and either mastectomy (n = 163) or BCS (n = 72). 50 Gy adjuvant radiotherapy (RT) was given for 53 BCS and 81 mastectomy patients. The BCS group was compared with the mastectomy group.
  
  
  RESULTS
  Patients treated with mastectomy or BCS had a similar outcome at 15 years with regard to distant metastasis-free (62% vs. 70%; p, 0.2017) and breast cancer-specific (62% vs. 70%; p, 0.1728) survival. In the BCS group the actuarial rate of ipsilateral in breast recurrences was 10% with and 53% without RT at 15 years (relative risk [RR], 0.10; p < 0.0001). In the mastectomy group the actuarial rate of chest wall recurrences was 16% with and 13% without RT at 15 years (RR, 1.45; p, 0.3965). Isolated ipsilateral in breast recurrence did not (RR, 1.73; p, 0.2767) but isolated chest-wall recurrence did (RR, 2.65; p, 0.0089) adversely affect cause-specific survival.
  
  
  CONCLUSIONS
  Breast cancer specific survival is not affected by the type of surgical treatment. BCS and RT is a safe option to control local disease in patients with ILC.
authors.affiliation: Department of Radiotherapy, National Institute of Oncology, Ráth Gy. u. 7-9, Budapest H-1122, Hungary.
authors.forename: János
authors.initials: J
authors.lastname: Fodor
authors.affiliation: Department of Radiotherapy, National Institute of Oncology, Ráth Gy. u. 7-9, Budapest H-1122, Hungary.
authors.forename: Tibor
authors.initials: T
authors.lastname: Major
authors.affiliation: Department of Pathology, National Institute of Oncology, Budapest, Hungary.
authors.forename: József
authors.initials: J
authors.lastname: Tóth
authors.affiliation: Department of Surgery, National Institute of Oncology, Budapest, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Sulyok
authors.affiliation: Department of Radiotherapy, National Institute of Oncology, Ráth Gy. u. 7-9, Budapest H-1122, Hungary.
authors.forename: Csaba
authors.initials: C
authors.lastname: Polgár
keywords: Breast-conserving therapy; Invasive lobular breast cancer; Mastectomy