title: Faulty ECM signaling facilitates autoimmune lymphomagenesis.
abstract: The contribution of the extracellular matrix (ECM) to the microenvironment of solid tumors is appreciated although not completely understood; however, the contribution of the ECM to the development of hematopoietic tumors has not been investigated in depth. A new study by Sangaletti and colleagues demonstrates that faulty ECM signaling can facilitate malignant lymphoproliferation in mice predisposed to autoimmunity. Similar changes in ECM construction, consistent with a loss of inhibitory ECM signaling, were identified in the transition from reactive lymphoid hyperplasia to malignant chronic lymphocytic leukemia in patients. These results reveal a critical contribution of reduced collagen signaling in lymphoma and highlight the importance of appropriate ECM construction for maintenance of tissue homeostasis.
authors.affiliation: Hamon Center for Therapeutic Oncology Research, Division of Surgical Oncology and Departments of Surgery and Pharmacology, UT Southwestern Medical Center, Dallas, Texas.
authors.forename: Rolf A
authors.initials: RA
authors.lastname: Brekken
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism; D015676:Osteonectin / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015676:Osteonectin; D003094:Collagen