title: [Everolimus and azoospermia, a causal relationship? About one case in a renal transplant patient].
abstract: Adverse effects of mTOR inhibitors on spermatogenesis are poorly evaluated but hypogonadism is described under sirolimus. We report the case of a renal transplant 30 years old patient in whom azoospermia was discovered while he was being treated by everolimus.
authors.affiliation: Service de néphrologie, CHU d'Amiens, avenue Laënnec, 80480 Salouel, France. Electronic address: morganewetzstein@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Wetzstein
authors.affiliation: Service de néphrologie, CHU d'Amiens, avenue Laënnec, 80480 Salouel, France.
authors.forename: P-F
authors.initials: PF
authors.lastname: Weestel
authors.affiliation: Service de néphrologie, CHU d'Amiens, avenue Laënnec, 80480 Salouel, France.
authors.forename: G
authors.initials: G
authors.lastname: Choukroun
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D053713:Azoospermia / Q000139:chemically induced*; D000077552:Basiliximab; D015984:Causality; D016572:Cyclosporine / Q000627:therapeutic use; D057915:Drug Substitution; D000068338:Everolimus; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D007248:Infertility, Male / Q000139:chemically induced; D016030:Kidney Transplantation; D008297:Male; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011993:Recombinant Fusion Proteins / Q000627:therapeutic use; D020123:Sirolimus / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D013091:Spermatogenesis / Q000187:drug effects; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000502:physiology
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents; D011993:Recombinant Fusion Proteins; D016572:Cyclosporine; D000077552:Basiliximab; D000068338:Everolimus; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D009173:Mycophenolic Acid; D020123:Sirolimus
keywords: Azoospermia; Azoospermie; Fertility; Fertilité; Immunosuppressive treatment; Inhibiteurs de mTOR; Renal transplant; Traitement immunosuppresseur; Transplantation rénale; mTOR inhibitors