title: Health Technology Assessment of CEM Pulpotomy in Permanent Molars with Irreversible Pulpitis.
abstract: BACKGROUND
  Teeth with irreversible pulpitis usually undergo root canal therapy (RCT). This treatment modality is often considered disadvantageous as it removes vital pulp tissue and weakens the tooth structure. A relatively new concept has risen which suggests vital pulp therapy (VPT) for irreversible pulpitis. VPT with calcium enriched mixture (VPT/CEM) has demonstrated favorable treatment outcomes when treating permanent molars with irreversible pulpitis. This study aims to compare patient related factors, safety and organizational consideration as parts of health technology assessment (HTA) of the new VPT/CEM biotechnology when compared with RCT.
  
  
  METHODS
  Patient related factors were assessed by looking at short- and long-term clinical success; safety related factors were evaluated by a specialist committee and discussion board involved in formulating healthcare policies. Organizational evaluation was performed and the social implications were assessed by estimating the costs, availability, accessibility and acceptability. The impact of VPT/CEM biotechnology was assessed by investigating the incidence of irreversible pulpitis and the effect of this treatment on reducing the burden of disease.
  
  
  RESULTS
  VPT/CEM biotechnology was deemed feasible and acceptable like RCT; however, it was more successful, accessible, affordable, available and also safer than RCT.
  
  
  CONCLUSIONS
  When considering socioeconomic implications on oral health status and oral health-related quality of life of VPT/CEM, the novel biotechnology can be more effective and more efficient than RCT in mature permanent molars with irreversible pulpitis.
authors.affiliation: Educational Development Center (EDC), Shahid Beheshti University of Medical Sciences, Tehran, Iran;
authors.forename: Shahram
authors.initials: S
authors.lastname: Yazdani
authors.affiliation: Department of Community Oral Health, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
authors.forename: Mohammad-Pooyan
authors.initials: MP
authors.lastname: Jadidfard
authors.affiliation: Department of Oral Public Health, Dental School, Isfahan University of Medical Science, Isfahan, Iran;
authors.forename: Bahareh
authors.initials: B
authors.lastname: Tahani
authors.affiliation: Department of Community Oral Health, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
authors.forename: Ali
authors.initials: A
authors.lastname: Kazemian
authors.affiliation: Department of Endodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran; ; Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran;
authors.forename: Omid
authors.initials: O
authors.lastname: Dianat
authors.affiliation: Iranian Center for Endodontic Research, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Laleh
authors.initials: L
authors.lastname: Alim Marvasti
keywords: CEM Cement; Calcium Enriched Mixture; Endodontics; Health Technology; Pulpitis; Pulpotomy; Root Canal Therapy; Vital Pulp Therapy