title: [Non-neuromeningeal cryptococcosis in patients with AIDS in Bamako, Mali: 2 case reports].
abstract: Non-neuromeningeal cryptococcosis forms resulting from disseminated infection are rarely reported in African literature and are non-documented in Malian medical ward. We report two clinical observations. Case 1: a 26-year-old patient, carrying the HIV-1 infection, in which the clinical examination revealed skin lesions simulating molluscum contagiosum and functional impairment of the lower limbs. Radiography of the lumbar spine showed vertebral osteolysis on L4-L5. Cryptococcal research remained negative in the CSF but positive at histological examination of the skin lesions and in pathological products of lumbosacral drainage. The treatment with fluconazole and ARV led to a favorable outcome. Case 2: a 42-year-old patient, admitted for fever cough, known for his non-compliance to ARVs and in which the examination found a syndrome of pleural condensation and a painful swelling of the outer third of the right clavicle (around the acromio-clavicular joint). Paraclinical investigations concluded in osteolysis of the acromial end of the right clavicle and an image of the right lung with abundant effusion. Cryptococcal research was positive in the pleural effusion and in the product of aspiration of acromio-clavicular tumefaction, negative in CSF. It seems important to think of a cryptococcal etiology even in the absence of clinical meningeal signs in front of any cutaneous sign and any fluctuating swelling in HIV+ patient.
authors.affiliation: Service des maladies infectieuses, CHU du Point G, Bamako, Mali. Electronic address: minta_daouda@yahoo.fr.
authors.forename: D K
authors.initials: DK
authors.lastname: Minta
authors.affiliation: Service des maladies infectieuses, CHU du Point G, Bamako, Mali.
authors.forename: A M
authors.initials: AM
authors.lastname: Traoré
authors.affiliation: Service des maladies infectieuses, CHU du Point G, Bamako, Mali.
authors.forename: I
authors.initials: I
authors.lastname: Coulibaly
authors.affiliation: Service des maladies infectieuses, CHU du Point G, Bamako, Mali.
authors.forename: K
authors.initials: K
authors.lastname: Diallo
authors.affiliation: Service de médecine interne, CHU du Point G, Bamako, Mali.
authors.forename: A
authors.initials: A
authors.lastname: Soukho-Kaya
authors.affiliation: Laboratoire de parasito-mycologie DEAP/FM, Bamako, Mali.
authors.forename: A
authors.initials: A
authors.lastname: Dolo
authors.affiliation: Laboratoire d'anatomie-cytologie pathologie, CHU du Point G, Bamako, Mali.
authors.forename: B
authors.initials: B
authors.lastname: Kamaté
authors.affiliation: Service des maladies infectieuses, CHU du Point G, Bamako, Mali.
authors.forename: D S
authors.initials: DS
authors.lastname: Ouologuem
authors.affiliation: Service de médecine interne, CHU du Point G, Bamako, Mali.
authors.forename: M
authors.initials: M
authors.lastname: Dembélé
authors.affiliation: Service de médecine interne, CHU du Point G, Bamako, Mali.
authors.forename: H A
authors.initials: HA
authors.lastname: Traoré
authors.affiliation: Laboratoire de parasito-mycologie, CHU d'Angers, Angers, France.
authors.forename: D
authors.initials: D
authors.lastname: Chabasse
authors.affiliation: Service des maladies infectieuses, CHU d'Angers, Angers, France.
authors.forename: E
authors.initials: E
authors.lastname: Pichard
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D000328:Adult; D044966:Anti-Retroviral Agents / Q000008:administration & dosage; D003453:Cryptococcosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D015725:Fluconazole / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008302:Mali
chemical_list: D044966:Anti-Retroviral Agents; D015725:Fluconazole
keywords: Bone; Cryptococcose; Cutanée; Disseminated; Disséminée; Extra-neuroméningée; Non-neuromeningeal; Osseuse; Pleural; Pleurale; Skin; VIH