title: Serum 25-hydroxyvitamin D level and extent and complexity of coronary artery disease.
abstract: BACKGROUND
  There are limited number of studies about relationship between serum vitamin D level and presence and severity of coronary artery disease (CAD). We assessed the relationship between the extent and complexity of CAD assessed by SYNTAX score and 25-hydroxyvitamin D level in patients with stable CAD.
  
  
  METHODS
  In the study, 209 consecutive patients with stable CAD (age: 63.1 ± 10.0 years) and 102 healthy control subjects (age 61.3 ± 13.7 years) were included. Serum 25-hydroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay and other biochemical markers were measured in all subjects. All subjects underwent coronary angiography and SS was calculated.
  
  
  RESULTS
  The mean serum 25-hydroxyvitamin D level of CAD group was lower than the control group (P < 0,001). Multivariate regression analysis showed that serum 25-hydroxyvitamin D level was independently associated with SYNTAX score (β = -0.396, P < 0.001), hypertension (β = -0.183, P = 0.003), high sensitive C-reactive protein (β = -0.141, P = 0.014), and body mass index (β = -0.135, P = 0.023) in patient group.
  
  
  CONCLUSIONS
  25-Hydroxyvitamin D level was associated with extent and complexity of CAD. 25-Hydroxyvitamin D may play a role in pathogenesis and severity of coronary atherosclerosis.
authors.affiliation: Adana Numune Training and Research Hospital, Department of Cardiology, Adana, Turkey.
authors.forename: Taner
authors.initials: T
authors.lastname: Seker
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Gülhan
authors.initials: G
authors.lastname: Yüksel Kalkan
authors.forename: Osman
authors.initials: O
authors.lastname: Kuloğlu
authors.forename: Nermin
authors.initials: N
authors.lastname: Yıldız Koyunsever
authors.forename: Durmuş
authors.initials: D
authors.lastname: Yıldıray Şahin
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.forename: Selahattin
authors.initials: S
authors.lastname: Akyol
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Hazar
authors.initials: H
authors.lastname: Harbalıoğlu
authors.forename: Murat
authors.initials: M
authors.lastname: Caylı
mesh_terms: D002118:Calcium / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010281:Parathyroid Hormone / Q000097:blood; D014463:Ultrasonography; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium
keywords: SYNTAX; artery; coronary; severity; vitamin D