title: Comparison of RECIST version 1.0 and 1.1 in assessment of tumor response by computed tomography in advanced gastric cancer.
abstract: OBJECTIVE
  Response Evaluation Criteria in Solid Tumors (RECIST) guideline version 1.0 (RECIST 1.0) was proposed as a new guideline for evaluating tumor response and has been widely accepted as a standardized measure. With a number of issues being raised on RECIST 1.0, however, a revised RECIST guideline version 1.1 (RECIST 1.1) was proposed by the RECIST Working Group in 2009. This study was conducted to compare CT tumor response based on RECIST 1.1 vs. RECIST 1.0 in patients with advanced gastric cancer (AGC).
  
  
  METHODS
  We reviewed 61 AGC patients with measurable diseases by RECIST 1.0 who were enrolled in other clinical trials between 2008 and 2010. These patients were retrospectively re-analyzed to determine the concordance between the two response criteria using the κ statistic.
  
  
  RESULTS
  The number and sum of tumor diameters of the target lesions by RECIST 1.1 were significantly lower than those by RECIST 1.0 (P<0.0001). However, there was excellent agreement in tumor response between RECIST 1.1 and RECIST 1.0 (κ=0.844). The overall response rates (ORRs) according to RECIST 1.0 and RECIST 1.1 were 32.7% (20/61) and 34.5% (20/58), respectively. One patient with partial response (PR) based on RECIST 1.0 was reclassified as stable disease (SD) by RECIST 1.1. Of two patients with SD by RECIST 1.0, one was downgraded to progressive disease and the other was upgraded to PR by RECIST 1.1.
  
  
  CONCLUSIONS
  RECIST 1.1 provided almost perfect agreement with RECIST 1.0 in the CT assessment of tumor response of AGC.
authors.affiliation: Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 431-070, South Korea;
authors.forename: Gil-Su
authors.initials: GS
authors.lastname: Jang
authors.affiliation: Department of Diagnostic Radiology, Hallym University Sacred Heart Hospital, Anyang 431-070, South Korea;
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Diagnostic Radiology, Hallym University Sacred Heart Hospital, Anyang 431-070, South Korea;
authors.forename: Hong-Il
authors.initials: HI
authors.lastname: Ha
authors.affiliation: Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul 136-705, South Korea.
authors.forename: Jung Han
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul 136-705, South Korea.
authors.forename: Hyeong Su
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul 136-705, South Korea.
authors.forename: Sung Bae
authors.initials: SB
authors.lastname: Ju
authors.affiliation: Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang 431-070, South Korea;
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Zang
keywords: Response Evaluation Criteria in Solid Tumors guideline version 1.0 (RECIST 1.0); Response Evaluation Criteria in Solid Tumors guideline version 1.1 (RECIST 1.1); gastric cancer; tumor response