title: In vitro characterization and mechanical properties of β-calcium silicate/POC composite as a bone fixation device.
abstract: Calcium silicate (CS, CaSiO3 ) is a bioactive, degradable, and biocompatible ceramic and has been considered for its potential in the field of orthopedic surgery. The objective of this study is the fabrication and characterization of the β-CS/poly(1.8-octanediol citrate) (POC) biocomposite, with the goals of controlling its weight loss and improving its biological and mechanical properties. POC is one of the most biocompatible polymers, and it is widely used in biomedical engineering applications. The degradation and bioactivity of the composites were determined by soaking the composites in phosphate-buffered saline and simulated body fluid, respectively. Human osteoblast cells were cultured on the composites to determine their cell proliferation and adhesion. The results illustrated that the flexural and compressive strengths were significantly enhanced by a modification of 40% POC. It was also concluded that the degradation bioactivity and amelioration of cell proliferation increased significantly with an increasing β-CS content.
authors.affiliation: Department of Mechanical Engineering and Advanced Material Research Center, University of Malaya, 50603, Kuala Lumpur, Malaysia.
authors.forename: F S
authors.initials: FS
authors.lastname: Shirazi
authors.forename: E
authors.initials: E
authors.lastname: Moghaddam
authors.forename: M
authors.initials: M
authors.lastname: Mehrali
authors.forename: A A
authors.initials: AA
authors.lastname: Oshkour
authors.forename: H S C
authors.initials: HS
authors.lastname: Metselaar
authors.forename: N A
authors.initials: NA
authors.lastname: Kadri
authors.forename: K
authors.initials: K
authors.lastname: Zandi
authors.forename: N A
authors.initials: NA
authors.lastname: Abu
mesh_terms: D017610:Calcium Compounds / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D002951:Citrates; D003188:Composite Resins / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D011108:Polymers; D017640:Silicates / Q000737:chemistry / Q000494:pharmacology
chemical_list: D017610:Calcium Compounds; D002951:Citrates; D003188:Composite Resins; D011108:Polymers; D017640:Silicates; C513817:poly(1,8-octanediol citrate); C031293:calcium silicate
keywords: biocompatibility; elastomer polymer; human osteoblast cell cultures; mechanical properties; β-calcium silicate