title: The effect of lidocaine on reducing the tracheal mucosal damage following tracheal intubation.
abstract: BACKGROUND
  The aim of this study was to investigate the efficacy of lidocaine solution in the cuff of the endotracheal tube in reducing mucosal damage following tracheal intubation.
  
  
  METHODS
  This was a randomized controlled trial study undertaken in the intensive care unit patients. Participants, who met all eligibility criteria, were randomly assigned to one of two groups of patients, according to whether lidocaine or air was used to fill the tracheal tube cuff. The tracheal mucosa at the site of cuff inflation was inspected by fiberoptic bronchoscopy and scored at the 24 h and 48 h after intubation.
  
  
  RESULTS
  In all, 51 patients (26 patients in the lidocaine group and 25 patients in the control group) completed the study. After 24 h, erythema and/or edema of tracheal mucosa were seen in 2 patients (7.7%) of lidocaine group and 6 patients (24%) of air group (P = 0.109). Binary logistic regression analysis showed that lidocaine has a significant protective effect against mucosal damage (odds ratio = 0.72, confidence interval = 0.60-0.87).
  
  
  CONCLUSIONS
  The inflation of the tracheal tube cuff with lidocaine was superior to air in decreasing the incidence of mucosal damage in the 24 h and 48 h post intubation.
authors.affiliation: Department of Anesthesiology and Intensive Care, Anesthesiology and Critical Care Research Center, Alzahra University Hospital, Isfahan, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Abbasi
authors.affiliation: Department of Anesthesiology and Intensive Care, Anesthesiology and Critical Care Research Center, Alzahra University Hospital, Isfahan, Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Mahjobipoor
authors.affiliation: Department of Anesthesiology and Intensive Care, Anesthesiology and Critical Care Research Center, Alzahra University Hospital, Isfahan, Iran.
authors.forename: Parviz
authors.initials: P
authors.lastname: Kashefi
authors.affiliation: Department of Anesthesiology and Intensive Care, Anesthesiology and Critical Care Research Center, Alzahra University Hospital, Isfahan, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Massumi
authors.affiliation: Department of Anesthesiology and Intensive Care, Anesthesiology and Critical Care Research Center, Alzahra University Hospital, Isfahan, Iran.
authors.forename: Omid
authors.initials: O
authors.lastname: Aghadavoudi
authors.affiliation: Department of Community Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ziba
authors.initials: Z
authors.lastname: Farajzadegan
authors.affiliation: Department of Anesthesiology and Intensive Care, Anesthesiology and Critical Care Research Center, Alzahra University Hospital, Isfahan, Iran.
authors.forename: Parvin
authors.initials: P
authors.lastname: Sajedi
keywords: Intubation; lidocaine; mechanical ventilation; mucosal damage