title: Circulating galanin and IL-6 concentrations in gestational diabetes mellitus.
abstract: OBJECTIVE
  The aim of this study is to compare galanin and IL-6 levels in pregnant women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT). Also association of insulin resistance markers, galanin and IL-6 was investigated.
  
  
  METHODS
  The study registered 30 pregnant women with GDM and 30 pregnant women with NGT. Fasting venous blood samples were collected from all patients. Galanin and IL-6 levels were measured by an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Galanin and IL-6 levels were found higher in pregnant women with GDM (p < 0.001). A significant positive correlation was determined between galanin concentrations and glucose (r = 0.240, p = 0.065), insulin (r = 0.681, p < 0.001), HbA1c (r = -0.644, p < 0.001), IL-6 (r = 0.783, p < 0.05) and oral glucose challenge test results (r = 0.745, p < 0.001) in pregnant women included in study, whereas no significant association was determined between galanin and gestational age (r = 0.058, p = 0.662), body mass index (r = -0.019, p = 0.886).
  
  
  CONCLUSIONS
  Galanin and IL-6 were found to be significantly associated with insulin resistance markers in GDM, thus may play important roles in regulation of glucose hemostasis.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Adnan Menderes University , Aydin , Turkey.
authors.forename: Sümeyra
authors.initials: S
authors.lastname: Nergiz
authors.forename: Özlem Sündüz
authors.initials: ÖS
authors.lastname: Altınkaya
authors.forename: Mert
authors.initials: M
authors.lastname: Küçük
authors.forename: Hasan
authors.initials: H
authors.lastname: Yüksel
authors.forename: Selda Demircan
authors.initials: SD
authors.lastname: Sezer
authors.forename: İmran
authors.initials: İ
authors.lastname: Kurt Ömürlü
authors.forename: Ali Rıza
authors.initials: AR
authors.lastname: Odabaşı
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016640:Diabetes, Gestational / Q000097:blood* / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019004:Galanin / Q000097:blood*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood*; D018384:Oxidative Stress; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D019004:Galanin; D006442:Glycated Hemoglobin; D007328:Insulin; D015850:Interleukin-6; C508600:IL6 protein, human; C517652:hemoglobin A1c protein, human