title: [Efficacy of combined local therapy especially with hepatic arterial infusion for liver metastasis from gastric cancer].
abstract: Herein, we report four cases of a single liver metastasis after gastric cancer resection. Initially, we chose to perform hepatic arterial infusion( HAI) with high-dose 5-fluorouracil( 5-FU)( 6,000 mg/week) or weekly 500-750 mg of 5-FU. Three patients showed a partial response (PR) and one patient showed no change (NC). Therefore, we performed hepatectomy or radiofrequency ablation( RFA) 300-350 days after HAI. All four patients received postoperative HAI. Two patients survived without recurrence for 12 and 21 months. One patient developed prostate cancer but survived for 22 months as an outpatient. Finally, one patient experienced recurrence in the residual liver, but at a site not supplied by the hepatic artery. This patient survived for 36 months as an outpatient. In conclusion, HAI, liver resection, and RFA are effective in the management of single liver metastasis from gastric cancer.
authors.affiliation: Dept. of Surgery, Nishinomiya Watanabe Hospital.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Hasuike
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Iwagami
authors.forename: Taisuke
authors.initials: T
authors.lastname: Toyomasu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yoshikawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirao
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Koshino
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Ishida
authors.forename: Kaname
authors.initials: K
authors.lastname: Tomoda
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D017115:Catheter Ablation; D003131:Combined Modality Therapy; D004338:Drug Combinations; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D012008:Recurrence; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid