title: Hormesis of glyceollin I, an induced phytoalexin from soybean, on budding yeast chronological lifespan extension.
abstract: Glyceollin I, an induced phytoalexin isolated from soybean, has been reported to have various bioactivities, including anti-bacterial, anti-nematode, anti-fungal, anti-estrogenic and anti-cancer, anti-oxidant, anti-inflammatory, insulin sensitivity enhancing, and attenuation of vascular contractions. Here we show that glyceollin I has hormesis and extends yeast life span at low (nM) doses in a calorie restriction (CR)-dependent manner, while it reduces life span and inhibits yeast cell proliferation at higher (μM) doses. In contrast, the other two isomers (glyceollin II and III) cannot extend yeast life span and only show life span reduction and antiproliferation at higher doses. Our results in anti-aging activity indicate that glyceollin I might be a promising calorie restriction mimetic candidate, and the high content of glyceollins could improve the bioactivity of soybean as functional food ingredients.
authors.affiliation: Hubei Key Laboratory of TCM Based Functional Food Quality and Safety, Jing Brand Company, Daye 435100, Hubei, China. lyc@jingpai.com.
authors.forename: Yuancai
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Hubei Key Laboratory of TCM Based Functional Food Quality and Safety, Jing Brand Company, Daye 435100, Hubei, China. wuziyun@gmail.com.
authors.forename: Ziyun
authors.initials: Z
authors.lastname: Wu
authors.affiliation: Hubei Key Laboratory of TCM Based Functional Food Quality and Safety, Jing Brand Company, Daye 435100, Hubei, China. fsb@jingpai.com.
authors.forename: Shengbao
authors.initials: S
authors.lastname: Feng
authors.affiliation: Hubei Key Laboratory of TCM Based Functional Food Quality and Safety, Jing Brand Company, Daye 435100, Hubei, China. yangxna@hotmail.com.
authors.forename: Xuena
authors.initials: X
authors.lastname: Yang
authors.affiliation: Hubei Key Laboratory of TCM Based Functional Food Quality and Safety, Jing Brand Company, Daye 435100, Hubei, China. chmhdj@nus.edu.sg.
authors.forename: Dejian
authors.initials: D
authors.lastname: Huang
mesh_terms: D049109:Cell Proliferation / Q000187:drug effects; D016922:Cellular Senescence / Q000187:drug effects; D059165:Hormesis / Q000187:drug effects*; D036343:Pterocarpans / Q000737:chemistry / Q000494:pharmacology*; D004718:Saccharomycetales / Q000187:drug effects* / Q000502:physiology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013025:Glycine max / Q000737:chemistry*; D000094162:Phytoalexins
chemical_list: D036343:Pterocarpans; D012717:Sesquiterpenes; C017343:glyceollin; D000094162:Phytoalexins