title: ε-Caprolactone in micro-chambered ceramic beads--a new carrier for gentamicin.
abstract: OBJECTIVE
  The purpose of this preliminary and descriptive study was to evaluate a biodegradable drug delivery system in combination with an innovative ceramic implant.
  
  
  METHODS
  The delivery of gentamicin of standardized samples was measured in the laboratory using ultra-high-performance liquid chromatography. Biocompatibility and biodegradation of the materials was investigated in an animal experiment in sheep up to 14 months. As carrier ε-caprolactone, 1:1 mixed with gentamicin, intruded into micro-chambered β-tricalcium-phosphate beads (MCB®) was studied.
  
  
  CONCLUSIONS
  Gentamicin was released in calculable concentrations during the first 30 days. The release from ε-caprolactone was higher than that from polymethylmethacrylate and more predictable. The caprolactone carrier was reabsorbed by osteoclasts.
authors.affiliation: Clinic for Restorative Dentistry and Periodontology, Ludwig-Maximilian University of Munich, Germany.
authors.forename: Miriam E
authors.initials: ME
authors.lastname: Draenert
authors.forename: Reinhard
authors.initials: R
authors.lastname: Hickel
authors.forename: Yvette
authors.initials: Y
authors.lastname: Draenert
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002208:Caproates / Q000737:chemistry* / Q000378:metabolism; D002516:Ceramics / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000737:chemistry*; D007719:Knee Joint / Q000473:pathology; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism; D012756:Sheep; D013203:Staphylococcal Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002208:Caproates; D004337:Drug Carriers; D005839:Gentamicins; D007783:Lactones; C121056:caprolactone