title: Severe aplastic anemia preceding acute monocytic leukemia in an adult with acquired trisomy 21: A case report.
abstract: The current case report presents a patient with acute monocytic leukemia (AML-M5) occurring 14 years following the successful treatment of severe aplastic anemia (SAA) with immunosuppressants and androgens. The patient was treated with induction chemotherapy, but did not achieve remission. The patient succumbed to central nervous system bleeding 2 weeks following the first cycle of chemotherapy. Chromosomal examination revealed 47,XX,+21[10]/46,XX[1]. To the best of our knowledge the present case is the first to be reported of SAA 14 years preceding AML-M5 with acquired trisomy 21.
authors.affiliation: Department of Hematology, The Central Hospital of Taian, Taian, Shandong 271000, P.R. China.
authors.forename: Dongmei
authors.initials: D
authors.lastname: Guo
authors.affiliation: Department of Hematology, The Central Hospital of Taian, Taian, Shandong 271000, P.R. China.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Hematology, The Central Hospital of Taian, Taian, Shandong 271000, P.R. China.
authors.forename: Banban
authors.initials: B
authors.lastname: Li
authors.affiliation: Department of Hematology, The Central Hospital of Taian, Taian, Shandong 271000, P.R. China.
authors.forename: Qingliang
authors.initials: Q
authors.lastname: Teng
keywords: leukemia; severe aplastic anemia; trisomy 21