title: Role of IL-10 in the progression of kidney disease.
abstract: Interleukin-10 (IL-10), a cytokine with anti-inflammatory and immunomodulatory functions, regulates the biology of B and T cells. The present review describes the role of IL-10 in normal renal physiology, during acute kidney injury and in the development of chronic renal failure. We further discuss IL-10-induced cellular and molecular pathways and their link to the progression of kidney injury.
authors.affiliation: Inna Sinuani, Judith Sandbank, Pathology Department, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, 70300, Israel.
authors.forename: Inna
authors.initials: I
authors.lastname: Sinuani
authors.affiliation: Inna Sinuani, Judith Sandbank, Pathology Department, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, 70300, Israel.
authors.forename: Ilia
authors.initials: I
authors.lastname: Beberashvili
authors.affiliation: Inna Sinuani, Judith Sandbank, Pathology Department, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, 70300, Israel.
authors.forename: Zhan
authors.initials: Z
authors.lastname: Averbukh
authors.affiliation: Inna Sinuani, Judith Sandbank, Pathology Department, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Zerifin, 70300, Israel.
authors.forename: Judith
authors.initials: J
authors.lastname: Sandbank
keywords: Allograft rejection; Cystatin C; End-stage renal disease; Epithelial-to-mesenchymal transition; Interleukin-10 receptor; Mesangial cell proliferation; Transforming growth factor-β