title: [Surgical outcomes and prognostic factors of primary colorectal cancer with peritoneal dissemination].
abstract: We evaluated the surgical outcomes and prognostic factors of primary colorectal cancer with peritoneal dissemination. Between 1990 and 2012, a total of 81 cases of operated primary colorectal cancer with peritoneal dissemination were reviewed. According to the classification by the degree of peritoneal dissemination, the 3-year overall survival rate of patients with P1, P2, and P3 were 22%, 14%, and 16%, respectively. A significant difference was not observed between these 3 groups. According to the degree of surgical curability, the 1-year and 3-year overall survival rates of the patients with curability B were 75% and 30%, respectively. The overall survival rate of patients with curability B was higher than those of curability C (p< 0.01). Multivariate analysis showed that the curability of operation (p=0.03) and the existence of hepatic metastases (p=0.01) were significant prognostic factors affecting overall survival. The median relapse-free survival time of patients with curability B was 7.8 months. Nevertheless, long-term survivor cases existed in this group. These findings suggest that complete resection of the primary tumor and metastatic lesions is important to prolong survival term.
authors.affiliation: Dept. of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine.
authors.forename: Seiji
authors.initials: S
authors.lastname: Takahashi
authors.forename: Eri
authors.initials: E
authors.lastname: Yoshida
authors.forename: Hajime
authors.initials: H
authors.lastname: Morohashi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Motoi
authors.initials: M
authors.lastname: Koyama
authors.forename: Akihiko
authors.initials: A
authors.lastname: Murata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000556:secondary*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome