title: Genetic polymorphism of ITGA2 C807T can increase the risk of ischemic stroke.
abstract: BACKGROUND
  The role of genetic variants in the pathogenesis of stroke has not been fully elucidated. Several studies have been examined the association of the Integrin alpha2 (ITGA2) gene-C807T (rs1126643) polymorphism with ischemic stroke susceptibility. However, the results of these studies are inconsistent. In order to explore this association more deeply, we performed a meta-analysis.
  
  
  METHODS
  We collected case-control studies concerning the relationship between the C807T polymorphism and ischemic stroke, and odd ratios (OR) with corresponding 95% confidence intervals (CI) were used to describe the relationships. Inconsistency index (I(2)) and Cochran's Q statistic were used to check heterogeneity. Publication bias was tested by funnel plots and Egger's test.
  
  
  RESULTS
  Fifteen studies with 2242 cases and 2408 controls were included. Our meta-analysis results indicated an association between the C807T polymorphism and the risk of ischemic stroke in the overall population, Asians and the subgroup of hospital-based people. However, statistically association was not observed for Caucasians and non-hospitalized individuals.
  
  
  CONCLUSIONS
  The ITGA2 gene C807T polymorphism may be a susceptible predictor of the risk of ischemic stroke. More data are needed to elucidate the relationship further.
authors.affiliation: 1Department of Internal Neurology, First Affiliated Hospital, Guangxi University of Chinese Medicine, Nanning, Guangxi, China.
authors.forename: Guangliang
authors.initials: G
authors.lastname: Wu
authors.forename: Yujing
authors.initials: Y
authors.lastname: Xi
authors.forename: Li
authors.initials: L
authors.lastname: Yao
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.forename: Yan
authors.initials: Y
authors.lastname: Yan
authors.forename: Minzhi
authors.initials: M
authors.lastname: Li
authors.forename: Lian
authors.initials: L
authors.lastname: Gu
mesh_terms: D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D039421:Integrin alpha2 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias / Q000706:statistics & numerical data; D020521:Stroke / Q000150:complications / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D039421:Integrin alpha2
keywords: C807T Polymorphism; ITGA2; ischemic stroke; meta-analysis