title: Clear cell papillary renal cell carcinoma is an indolent and low-grade neoplasm with overexpression of cyclin-D1.
abstract: OBJECTIVE
  Several entities have been individualized recently within the family of renal neoplasms with papillary features. Clear cell papillary renal cell carcinoma (CCPRCC) was first described in patients with end-stage renal disease, but is also observed in patients with normal renal function. The objective of this study was to document the clinicopathological and immunohistochemical characteristics of CCPRCC, with a special emphasis on cyclin D1 expression.
  
  
  RESULTS
  The patients were 25 men and 17 women, mean age 60.7 years. Seventeen patients had a chronic renal disease. All tumours were stage pT1, with a mean diameter of 2 cm. Six tumours were multifocal. Tumours cells were mainly cuboidal, with clear cytoplasm and low-grade nuclei apically aligned. In all cases, Fuhrman nuclear grade was one or two. No necrosis or vascular invasion was seen. During follow-up (10-72 months), no metastasis or death related to the disease was observed. Immunohistochemistry showed strong and diffuse cytokeratin 7 immunoreactivity in all cases, but no labelling for AMACR or TFE3. There was diffuse nuclear cyclin D1 immunoreactivity in 83% of cases.
  
  
  CONCLUSIONS
  CCPRCC is now a well-characterized entity. This tumour is an indolent and very low-grade neoplasm. Here we report the first study, to our knowledge, demonstrating the overexpression of cyclin D1 immunostaining by this tumour.
authors.affiliation: Department of Pathology, University Hospitals CHRU, Lille, France; University Lille Nord de France, Lille, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.forename: Philippe
authors.initials: P
authors.lastname: Camparo
authors.forename: Viviane
authors.initials: V
authors.lastname: Gnemmi
authors.forename: Sebastien
authors.initials: S
authors.lastname: Aubert
authors.forename: Vincent
authors.initials: V
authors.lastname: Flamand
authors.forename: Morgan
authors.initials: M
authors.lastname: Roupret
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Fantoni
authors.forename: Eva
authors.initials: E
authors.lastname: Comperat
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading
chemical_list: D014408:Biomarkers, Tumor; C530104:CCND1 protein, human; D019938:Cyclin D1
keywords: clear cell papillary carcinoma; cyclin D1; immunohistochemistry; kidney