title: Long-term Effect of Sodium Oxybate (Xyrem®) in Spasmodic Dysphonia with Vocal Tremor.
abstract: BACKGROUND
  Symptoms of spasmodic dysphonia (SD) are usually managed successfully with botulinum toxin injections. Vocal tremor (VT), which accompanies SD, has a poor response to this treatment.
  
  
  METHODS
  We report a case of a female with SD and VT who became symptom-free for 10 months after the intake of a single dose of sodium oxybate (Xyrem®). The long-term treatment effect correlated with attenuated brain activity in the key regions of dystonic brain network.
  
  
  CONCLUSIONS
  Our case demonstrates that the novel treatment of sodium oxybate may hold promise for SD patients, especially those who have associated VT.
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, , United States of America ; Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, NY, , United States of America.
authors.forename: Kristina
authors.initials: K
authors.lastname: Simonyan
authors.affiliation: Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, , United States of America.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Frucht
keywords: Focal dystonia; brain modulation; treatment