title: Downregulation of CD4+LAP+ and CD4+CD25+ regulatory T cells in acute coronary syndromes.
abstract: BACKGROUND
  Regulatory T (Treg) cells play a protective role in atherosclerosis prone models and are related to the onset of acute coronary syndromes (ACS, including non-ST-elevation ACS (NSTEACS) and ST-elevation acute myocardial infarction (STEAMI)). CD4+LAP+ Treg cells are a novel subset of Tregs that have been found to ameliorate atherosclerosis in ApoE(-/-) mice, and these cells also exist in humans. The present study was designed to investigate whether CD4+LAP+ Treg cells are involved in the onset of ACS.
  
  
  METHODS
  The frequencies of CD4+LAP+ and CD4+CD25+ Treg cells were detected using flow cytometric analysis, and the plasma IL-10 and TGF- β 1 levels were measured using an ELISA in 29 stable angina (SA) patients, 30 NSTEACS patients, 27 STEAMI patients, and a control group (30 cases).
  
  
  RESULTS
  The results revealed a significant decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells and in the levels of IL-10 and TGF- β 1 in patients with ACS compared with those in the SA and control groups.
  
  
  CONCLUSIONS
  The decrease in the frequencies of CD4+LAP+ and CD4+CD25+ Treg cells may play a role in the onset of ACS.
authors.affiliation: Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Ying-zhong
authors.initials: YZ
authors.lastname: Lin
authors.affiliation: Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Shan-he
authors.initials: SH
authors.lastname: Lu
authors.affiliation: Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Zheng-de
authors.initials: ZD
authors.lastname: Lu
authors.affiliation: Department of Ultrasound, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Ultrasound, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Wang
authors.affiliation: Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
authors.forename: Qing-wei
authors.initials: QW
authors.lastname: Ji
mesh_terms: D054058:Acute Coronary Syndrome / Q000276:immunology* / Q000503:physiopathology; D000368:Aged; D015536:Down-Regulation; D005260:Female; D051858:Forkhead Transcription Factors / Q000502:physiology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000502:physiology*; D011498:Protein Precursors / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000502:physiology*; D053773:Transforming Growth Factor beta1 / Q000097:blood; D016277:Ventricular Function, Left
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D010455:Peptides; D011498:Protein Precursors; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; C472416:latency-associated propeptide, TGF-beta; D016753:Interleukin-10