title: Results of patient specific quality assurance for patients undergoing stereotactic ablative radiotherapy for lung lesions.
abstract: Hypofractionated image guided radiotherapy of extracranial targets has become increasingly popular as a treatment modality for inoperable patients with one or more small lesions, often referred to as stereotactic ablative body radiotherapy (SABR). This report details the results of the physical quality assurance (QA) program used for the first 33 lung cancer SABR radiotherapy 3D conformal treatment plans in our centre. SABR involves one or few fractions of high radiation dose delivered in many small fields or arcs with tight margins to mobile targets often delivered through heterogeneous media with non-coplanar beams. We have conducted patient-specific QA similar to the more common intensity modulated radiotherapy QA with particular reference to motion management. Individual patient QA was performed in a Perspex phantom using point dose verification with an ionisation chamber and radiochromic film for verification of the dose distribution both with static and moving detectors to verify motion management strategies. While individual beams could vary by up to 7%, the total dose in the target was found to be within ±2% of the prescribed dose for all 33 plans. Film measurements showed qualitative and quantitative agreement between planned and measured isodose line shapes and dimensions. The QA process highlighted the need to account for couch transmission and demonstrated that the ITV construction was appropriate for the treatment technique used. QA is essential for complex radiotherapy deliveries such as SABR. We found individual patient QA helpful in setting up the technique and understanding potential weaknesses in SABR workflow, thus providing confidence in SABR delivery.
authors.affiliation: Department of Physical Sciences, Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, VIC, 3002, Australia, nicholas.hardcastle@petermac.org.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Hardcastle
authors.forename: Natalie
authors.initials: N
authors.lastname: Clements
authors.forename: Brent
authors.initials: B
authors.lastname: Chesson
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Aarons
authors.forename: Jim
authors.initials: J
authors.lastname: Cramb
authors.forename: Shankar
authors.initials: S
authors.lastname: Siva
authors.forename: Derrick M
authors.initials: DM
authors.lastname: Wanigaratne
authors.forename: David
authors.initials: D
authors.lastname: Ball
authors.forename: Tomas
authors.initials: T
authors.lastname: Kron
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D019047:Phantoms, Imaging; D011785:Quality Assurance, Health Care / Q000706:statistics & numerical data*; D016634:Radiosurgery / Q000295:instrumentation / Q000379:methods*; D014057:Tomography, X-Ray Computed