title: Once-daily topical treatment for psoriasis: calcipotriene + betamethasone two-compound topical formulation.
abstract: BACKGROUND
  Topical treatments are usually effective in mild psoriasis. However, the complexity of their use may result in low patient adherence with treatment. Combination of a vitamin D analog and a corticosteroid into a two-compound topical formulation has increased efficacy compared with either drug administered alone. Once-daily application of such a product would likely improve adherence. The purpose of this study was to determine whether twice-daily application of a calcipotriene + betamethasone topical formulation can provide improved clinical outcomes compared with once-daily treatment with the same product.
  
  
  METHODS
  A review of the literature was performed seeking clinical trials comparing once-daily versus twice-daily application of calcipotriene + betamethasone topical formulations for the treatment of psoriasis.
  
  
  RESULTS
  We found only one relevant clinical trial. This study showed similar efficacy and safety with once-daily versus twice-daily application of a topical calcipotriene + betamethasone formulation in the treatment of psoriasis vulgaris.
  
  
  CONCLUSIONS
  Once-daily application of a topical calcipotriene + betamethasone formulation may offer increased patient convenience and potentially increased patient adherence with long-term treatment, compared with twice-daily use, without reducing the efficacy. In order to enhance adherence, patient preference regarding frequency of application of topical treatments should be considered when prescribing medications.
authors.affiliation: Center for Dermatology Research, Department of Dermatology, Winston-Salem, NC, USA.
authors.forename: Jonisha
authors.initials: J
authors.lastname: Shepherd
authors.affiliation: Center for Dermatology Research, Department of Dermatology, Winston-Salem, NC, USA.
authors.forename: Arash
authors.initials: A
authors.lastname: Taheri
authors.affiliation: Center for Dermatology Research, Department of Dermatology, Winston-Salem, NC, USA ; Department of Pathology, Winston-Salem, NC, USA ; Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Feldman
keywords: betamethasone; calcipotriene; combination product; once daily; psoriasis; twice daily