title: Parallel evolution of IDH2 gene in cetaceans, primates and bats.
abstract: Cetaceans and primates both have large brains that require large amounts of aerobic energy metabolism. In bats, the cost of flight makes locomotion energetically demanding. These mammalian groups may represent three independent evolutionary origins of an energy-demanding lifestyle in mammals. IDH2 encodes an enzyme in the tricarboxylic acid cycle in the mitochondrion, which plays a key role in aerobic energy metabolism. In this study, we cloned and sequenced this gene in two cetaceans, and 19 bat species, and compared the data with available primate sequences to test its evolution. We found significant signals of parallel evolution in this gene among these three groups. Parallel evolution of this gene may reflect their parallel evolution towards a higher demand for energy.
authors.affiliation: Department of Marine Science, School of Life Science, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Ai
authors.affiliation: Department of Marine Science, School of Life Science, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Shao-Bo
authors.initials: SB
authors.lastname: Chen
authors.affiliation: Department of Marine Science, School of Life Science, Wenzhou Medical College, Wenzhou 325035, China; Guangxi Key Lab for Mangrove Conservation and Utilization, Guangxi Mangrove Research Center, Beihai 536000, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Chen
authors.affiliation: Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College, Shantou 515041, China.
authors.forename: Xue-Juan
authors.initials: XJ
authors.lastname: Shen
authors.affiliation: Joint Influenza Research Centre (SUMC/HKU), Shantou University Medical College, Shantou 515041, China; State Key Laboratory of Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China. Electronic address: shenyy@mail.kiz.ac.cn.
authors.forename: Yong-Yi
authors.initials: YY
authors.lastname: Shen
mesh_terms: D000818:Animals; D001483:Base Sequence; D002591:Cetacea / Q000235:genetics*; D002685:Chiroptera / Q000235:genetics*; D003001:Cloning, Molecular; D019143:Evolution, Molecular; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D010802:Phylogeny; D011323:Primates / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase
keywords: Adaptive evolution; Bat; Dolphin; Energy metabolism; Parallel evolution