title: Bisphenol A and human chronic diseases: current evidences, possible mechanisms, and future perspectives.
abstract: Bisphenol-A (BPA) is one of the highest volume chemicals produced worldwide, with over 6billion pounds produced and over 100t released into the atmosphere each year. Recent extensive literature has raised concerns about its possible implication in the etiology of some human chronic diseases such as diabetes, obesity, reproductive disorders, cardiovascular diseases, birth defects, chronic respiratory and kidney diseases and breast cancer. In this review, we present the highlighted evidences on the relationship between BPA exposure and human chronic diseases and we discuss its eventual mechanisms of action, especially genetic, epigenetic and endocrine disruption mechanisms with the possible involvement of oxidative stress, mitochondrial dysfunction and cell signaling.
authors.affiliation: University of Tunis El Manar, Faculty of Sciences of Tunis, Laboratory of Physiology of the Aggressions, Tunisia; University of Monastir, High Institute of Biotechnology of Monastir, Department of Biology, Tunisia. Electronic address: raja.rezg@laposte.net.
authors.forename: Raja
authors.initials: R
authors.lastname: Rezg
authors.affiliation: University of Tunis El Manar, Faculty of Sciences of Tunis, Laboratory of Physiology of the Aggressions, Tunisia.
authors.forename: Saloua
authors.initials: S
authors.lastname: El-Fazaa
authors.affiliation: University of Tunis El Manar, Faculty of Sciences of Tunis, Laboratory of Physiology of the Aggressions, Tunisia.
authors.forename: Najoua
authors.initials: N
authors.lastname: Gharbi
authors.affiliation: University of Tunis El Manar, Faculty of Sciences of Tunis, Laboratory of Physiology of the Aggressions, Tunisia; University of Gabes, Faculty of Sciences of Gabes, Department of Life Sciences, Tunisia.
authors.forename: Bessem
authors.initials: B
authors.lastname: Mornagui
mesh_terms: D001559:Benzhydryl Compounds / Q000009:adverse effects*; D064419:Chemically-Induced Disorders; D002908:Chronic Disease; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects*; D006801:Humans; D010636:Phenols / Q000009:adverse effects*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Chronic human diseases; Etiology; Mechanisms