title: [Calcium supplementation in healthy subjects: benefits and risks].
abstract: Over recent years the cardiovascular safety of calcium supplementation, taken by millions on a daily basis, has raised concerns. Despite the borderline benefit of calcium supplementation in regards to fracture risk reduction, osteoporosis guidelines continue to advocate daily calcium supplementation assuming that calcium does no harm. However, reanalysis of large randomised controlled trials (RCTs) and observational studies consistently show a modest, but significant increased cardiovascular risk in healthy individuals taking calcium supplementation. The aim of this review is summarise recent data demonstrating elevated cardiovascular risk possibly attributable to oral calcium supplementation in healthy individuals.
authors.forename: Michael
authors.initials: M
authors.lastname: Drozd
authors.forename: Klaus
authors.initials: K
authors.lastname: Witte
mesh_terms: D002118:Calcium / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D019587:Dietary Supplements / Q000009:adverse effects*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment
chemical_list: D002118:Calcium