title: Physical activity versus sedentary behavior: associations with lipoprotein particle subclass concentrations in healthy adults.
abstract: BACKGROUND
  Physical activity (PA) and sedentary behavior (SED) may have independent effects on health and disease. This might be due to PA and SED having distinct effects on lipoprotein metabolism. The aim of this study was to determine associations between lipoprotein subclass particle concentrations (-P) and accelerometer-measured SED and moderate-to-vigorous PA (MVPA) in a sample of healthy adult subjects.
  
  
  METHODS
  Lipoprotein subclass particle concentrations were determined by proton nuclear magnetic resonance spectroscopy, whereas SED and MVPA were measured using Agtigraph GT1M and GT3X+ accelerometers. We obtained valid data in 73 subjects (30 men and 43 women, age 40.5 ± 10.6 years; body mass index 24.0 ± 2.8). Multiple regression analysis was used to determine associations (partial correlations) with lipoproteins.
  
  
  RESULTS
  Positive associations were detected between SED and small VLDL-P, large LDL-P and TG (partial r = 0.24 to 0.25, p < .047). Corresponding associations were non-significant for MVPA (partial r = -0.12 to 0.04, p > .355). On the contrary, MVPA was positively associated with large HDL-P, average HDL size, Apo A1 and HDL-cholesterol (partial r = 0.28 to 0.50, p < .027), whereas SED was not (partial r = -0.06 to 0.07, p > .607).
  
  
  CONCLUSIONS
  There might be a specific effect of SED versus MVPA on lipoprotein metabolism. However, our results must be interpreted carefully due to possible effect-modification by gender and a low sample size. Thus, our findings should be viewed as preliminary.
authors.affiliation: Faculty of Health Studies, Sogn og Fjordane University College, Førde, Norway.
authors.forename: Eivind
authors.initials: E
authors.lastname: Aadland
authors.affiliation: Faculty of Health Studies, Sogn og Fjordane University College, Førde, Norway ; Department of Surgery, Førde Central Hospital, Førde, Norway.
authors.forename: John Roger
authors.initials: JR
authors.lastname: Andersen
authors.affiliation: Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway ; Faculty of Teacher Education and Sports, Sogn og Fjordane University College, Sogndal, Norway.
authors.forename: Sigmund Alfred
authors.initials: SA
authors.lastname: Anderssen
authors.affiliation: Faculty of Health Studies, Sogn og Fjordane University College, Førde, Norway ; Department of Chemistry, University of Bergen, Bergen, Norway.
authors.forename: Olav Martin
authors.initials: OM
authors.lastname: Kvalheim
mesh_terms: D000293:Adolescent; D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D057185:Sedentary Behavior
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL