title: Increasing incidence of melanoma among middle-aged adults: an epidemiologic study in Olmsted County, Minnesota.
abstract: OBJECTIVE
  To identify changes in the incidence of cutaneous melanoma over time in the fastest-growing segment of the US population-middle-aged adults.
  
  
  METHODS
  By using the Rochester Epidemiology Project resource, we identified patients aged 40 to 60 years who had a first lifetime diagnosis of melanoma between January 1, 1970, and December 31, 2009, in Olmsted County, Minnesota. The incidence of melanoma and overall and disease-specific survival rates were compared by age, sex, year of diagnosis, and stage of disease.
  
  
  RESULTS
  Between 1970 and 2009, age- and sex-adjusted incidence increased significantly over time (P<.001) from 7.9 to 60.0 per 100,000 person-years, with a 24-fold increase in women and a 4.5-fold increase in men. Although not significant (P=.06), the incidence of melanoma increased with age. Overall and disease-specific survival improved over time, with hazard ratios of 0.94 (P<.001) and 0.93 (P<.001) for each 1-year increase in the year of diagnosis, respectively. Each 1-year increase in the age at diagnosis was associated with an increased risk of death from any cause (hazard ratio, 1.07; P=.01) but was not significantly associated with disease-specific death (P=.98). Sex was not significantly associated with death from any cause (P=.81) or death from disease (P=.23). No patient with malignant melanoma in situ died from disease. Patients with stage II, III, and IV disease were more than 14 times more likely to die from disease than were patients with stage 0 or I disease (P<.001).
  
  
  CONCLUSIONS
  The incidence of cutaneous melanoma among middle-aged adults increased over the past 4 decades, especially in middle-aged women, whereas mortality decreased.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN.
authors.forename: Garrett C
authors.initials: GC
authors.lastname: Lowe
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Saavedra
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN.
authors.forename: Kurtis B
authors.initials: KB
authors.lastname: Reed
authors.affiliation: Division of Medical Oncology, Mayo Clinic, Rochester, MN.
authors.forename: Ana I
authors.initials: AI
authors.lastname: Velazquez
authors.affiliation: Division of Medical Oncology, Mayo Clinic, Rochester, MN.
authors.forename: Roxana S
authors.initials: RS
authors.lastname: Dronca
authors.affiliation: Division of Medical Oncology, Mayo Clinic, Rochester, MN; Division of Hematology, Mayo Clinic, Rochester, MN; Division of Clinical Immunology and Immunotherapeutics, Mayo Clinic, Rochester, MN.
authors.forename: Svetomir N
authors.initials: SN
authors.lastname: Markovic
authors.affiliation: Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN.
authors.forename: Christine M
authors.initials: CM
authors.lastname: Lohse
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN. Electronic address: brewer.jerry@mayo.edu.
authors.forename: Jerry D
authors.initials: JD
authors.lastname: Brewer
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008545:Melanoma / Q000453:epidemiology*; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D017678:Sex Distribution; D012737:Sex Factors; D012878:Skin Neoplasms; D015996:Survival Rate; D000096142:Cutaneous Malignant Melanoma
keywords: REP; Rochester Epidemiology Project