title: Update in systemic therapy of urologic malignancies.
abstract: Systemic therapy of advanced prostate and renal cancers has gained several recent additions to the therapeutic armamentarium. Treatment of patients with castration-resistant prostate cancer now includes additional immunotherapy (sipuleucel-T), chemotherapy (cabazitaxel), androgen-signaling inhibitors (abiraterone acetate, enzalutamide), and a radiopharmaceutical (alpharadin), based on extension of patient survival. Similarly, therapy for patients with renal cell carcinoma, a chemoresistant malignancy, has undergone dramatic changes based on an understanding of the role of angiogenesis. Multiple vascular endothelial growth factor inhibitors (sorafenib, sunitinib, pazopanib, axitinib, bevacizumab) and mammalian target of rapamycin inhibitors (temsirolimus, everolimus) have been added to the therapeutic arsenal. Additionally, immunotherapy retains an important treatment role, with a continuing application of high-dose interleukin-2 in select patients and the emergence of novel immunotherapeutic agents that may have significant benefit. Other major urologic malignancies, including urothelial, testicular, and penile cancers, have witnessed relatively few or no recent advances in therapy, although testicular germ cell tumors are one of the most curable malignancies. An agent for treatment of advanced urothelial cancer now has commercial approval, the chemotherapeutic agent, vinflunine, as second-line therapy in multiple countries-but not in the United States. Our review summarizes and updates the field of systemic therapy for advanced urologic malignancies, with a focus on castration-resistant prostate cancer and renal cell carcinoma.
authors.affiliation: University of Alabama, Birmingham (UAB) Comprehensive Cancer Center, Birmingham, AL.
authors.forename: David
authors.initials: D
authors.lastname: Mooney
authors.forename: Ravikumar
authors.initials: R
authors.lastname: Paluri
authors.forename: Amitkumar
authors.initials: A
authors.lastname: Mehta
authors.forename: Jatinder
authors.initials: J
authors.lastname: Goyal
authors.forename: Guru
authors.initials: G
authors.lastname: Sonpavde
mesh_terms: D000726:Androgen Antagonists / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008870:Microtubules / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors
chemical_list: D000726:Androgen Antagonists; D000970:Antineoplastic Agents; D019275:Radiopharmaceuticals; D042461:Vascular Endothelial Growth Factor A; D058570:TOR Serine-Threonine Kinases