title: Duplex sonography of cerebral blood flow after cardiac arrest--a prospective observational study.
abstract: OBJECTIVE
  Despite successful resuscitation, cardiac arrest (CA) often has a poor clinical prognosis. Different diagnostic tools have been established to predict patients' outcome. However, their sensitivity remains low. Assessment of cerebral perfusion by duplex ultrasound might provide additional information regarding the extent of neuronal damage. The aim of the present study was to analyse the changes of global cerebral blood flow (CBF) and intracranial blood flow parameters in the acute stage after CA and its correlation with patients' outcome.
  
  
  METHODS
  We investigated 54 patients (17-85 years, mean age: 63±17 years) after CA with return of spontaneous circulation on an intensive care unit. All patients received therapeutic hypothermia (TH) for 24 h after CA and reanimation. Serial measurements of CBF as well as intracranial blood flow velocities and pulsatility indices of the middle cerebral artery and the basal vein of Rosenthal were performed within the first 10 days using duplex ultrasound. Clinical outcome was measured using the Cerebral Performance Category.
  
  
  RESULTS
  Measurements were successful in 53 patients. CBF values differed between 210 and 1100 ml/min. 24 patients (45%) attained a good outcome. No correlation between CBF or intracranial blood flow characteristics and outcome was found. Neither cerebral hypo- nor hyperperfusion was associated with a fatal outcome.
  
  
  CONCLUSIONS
  Cerebral perfusion varies widely after CA. Neither hypo- nor hyperperfusion seems to be an independent risk factor for poor outcome. Duplex ultrasound of cerebral haemodynamics after CA is suitable but probably of limited prognostic value.
authors.affiliation: Department of Neurology, University Hospital Charité, Berlin, Germany. Electronic address: florian.connolly@charite.de.
authors.forename: Florian
authors.initials: F
authors.lastname: Doepp Connolly
authors.affiliation: Department of Neurology, University Hospital Charité, Berlin, Germany.
authors.forename: Johanna
authors.initials: J
authors.lastname: Reitemeier
authors.affiliation: Department of Internal Medicine, University Hospital Charité, Berlin, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Storm
authors.affiliation: Department of Internal Medicine, University Hospital Charité, Berlin, Germany.
authors.forename: Dietrich
authors.initials: D
authors.lastname: Hasper
authors.affiliation: Department of Neurology, University Hospital Charité, Berlin, Germany.
authors.forename: Stephan J
authors.initials: SJ
authors.lastname: Schreiber
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D002550:Cerebral Veins / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006323:Heart Arrest / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000503:physiopathology; D011379:Prognosis; D011446:Prospective Studies; D011673:Pulsatile Flow / Q000502:physiology; D017585:Ultrasonography, Doppler, Transcranial; D055815:Young Adult
keywords: Basal vein of Rosenthal; Cardiac arrest; Cerebral blood flow; Duplexsonography; Middle cerebral artery; Therapeutic hypothermia