title: Anticomplement monoterpenoid glucosides from the root bark of Paeonia suffruticosa.
abstract: Six new (1-6) and 19 known monoterpenoid glucosides were isolated from the root bark of Paeonia suffruticosa. The monoterpenoid glucosides 1, 2, 7, 10-19, and 22 exhibited anticomplement effects with CH50 and AP50 values ranging from 0.14 to 2.67 mM and 0.25 to 3.67 mM, respectively. In a mechanistic study, suffrupaeoniflorin A (1) interacted with C1q, C3, C5, and C9, while galloylpaeoniflorin (12) and galloyloxypaeoniflorin (19) acted on C1q, C3, and C5 components in the complement activation cascade.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University , Shanghai 201203, People's Republic of China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Song
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Cheng
authors.forename: Dao-Feng
authors.initials: DF
authors.lastname: Chen
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic; D015922:Complement C1q / Q000187:drug effects; D003176:Complement C3 / Q000187:drug effects; D003182:Complement C5 / Q000187:drug effects; D003186:Complement C9 / Q000187:drug effects; D003165:Complement System Proteins / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029596:Paeonia / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D003176:Complement C3; D003182:Complement C5; D003186:Complement C9; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D039821:Monoterpenes; C119233:galloylpaeoniflorin; C587336:suffrupaeoniflorin A; C077821:galloyloxypaeoniflorin; D005707:Gallic Acid; D015922:Complement C1q; D003165:Complement System Proteins