title: Association between interleukin-10 -1082A/G, -819C/T and -592C/A polymorphisms with deep venous thrombosis.
abstract: BACKGROUND
  Deep venous thrombosis (DVT) and inflammation are two closely related entities. The objective of this study was to evaluate a possible association between interleukin-10 (IL-10) -1082A/G, -819C/T and -592C/A polymorphisms with DVT.
  
  
  METHODS
  A case-control study was carried out in 660 patients with DVT and 660 age- and gender-matched healthy controls. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to identify the polymorphisms mentioned.
  
  
  RESULTS
  Patients with DVT had a significantly lower frequency of IL-10 -1082GG genotype [odds ratio (OR)=0.59, 95% confidence interval (CI)=0.39, 0.89; P=0.01] than healthy controls. When stratifying by family history of DVT, it was found that patients with positive family history of DVT had a significantly lower frequency of IL-10 -1082GG genotype (OR=0.13, 95% CI=0.02, 0.95; P=0.04). When stratifying by smoking status, presence of varicose veins, type 2 diabetes mellitus and any hormone administration before, no significant differences were found in any groups.
  
  
  CONCLUSIONS
  This study provides evidence that IL-10 -1082A/G polymorphism associated with risk of DVT. However, no association of the IL-10 -592C/A or -819C/T polymorphism with DVT risk was found. Additional well-designed large studies were required for the validation of our results.
authors.affiliation: Department of Vascular Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China.
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
authors.affiliation: Department of Vascular Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China.
authors.forename: Yi-Kuan
authors.initials: YK
authors.lastname: Chen
authors.affiliation: Department of Vascular Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China.
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Luo
authors.affiliation: Department of Vascular Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Fu
authors.affiliation: Department of Vascular Surgery, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, PR China. Electronic address: jianmingsun@live.cn.
authors.forename: Jian-Ming
authors.initials: JM
authors.lastname: Sun
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D020246:Venous Thrombosis / Q000235:genetics / Q000276:immunology*
chemical_list: D016753:Interleukin-10