title: The inflammatory cellular constituents of foetal and infant leptomeninges: a survey of hospital-based autopsies without trauma.
abstract: OBJECTIVE
  Notwithstanding the lack of definitive evidence from studies conducted to date, inflammatory infiltrates and iron deposition in the leptomeninges are routinely used as forensic markers of traumatic brain injury. We investigated the presence of these forensic markers of trauma in neonates and infants, with the objective of determining their suitability for use in forensic cases.
  
  
  METHODS
  Leptomeninges derived from non-traumatic deaths were studied. Thirty-three cases were divided into groups 1 and 2, according to set age groups. Inflammatory cells and iron in these groups were quantified.
  
  
  RESULTS
  CD45, CD68 and CD163 positive inflammatory cells were identified in the leptomeninges of sections of the cerebellum, brain stem and cortex of all 33 cases of non-traumatic infant deaths surveyed in this study. There were no significant differences between the two groups. Iron was found in the leptomeninges in several cases, even those without recent haemorrhage. Overall within the two subgroups, the numbers of inflammatory cells and iron containing cells were not significantly different.
  
  
  CONCLUSIONS
  These findings demonstrate that inflammatory cells and iron in the leptomeninges can be found in natural and non-traumatic conditions. Further, two cases with no reported neuropathology demonstrated the presence of inflammatory cells and iron. Thus, cautious interpretation of the presence of inflammatory cells and iron containing cells in forensic paediatric cases is recommended.
authors.affiliation: Our Lady of Lourdes Hospital, Drogheda, Ireland, estherjack@rcsi.ie.
authors.forename: Esther
authors.initials: E
authors.lastname: Jack
authors.forename: Neil K
authors.initials: NK
authors.lastname: Fennelly
authors.forename: Terri
authors.initials: T
authors.lastname: Haddix
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D001930:Brain Injuries / Q000150:complications; D004660:Encephalitis / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007501:Iron / Q000378:metabolism; D008297:Male; D008578:Meninges / Q000378:metabolism / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D015703:Antigens, CD; D007501:Iron