title: Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction.
abstract: Like other CNS neurons, mature retinal ganglion cells (RGCs) cannot regenerate their axons after nerve injury due to loss of regenerative capacity. One of the reasons why they lose their capacity seems to be a dramatic shift in gene expression of RGCs under epigenetic modulation. In here, we found that levels of histone H3 lysine 9 acetylation decreased after birth in RGCs. This decrease showed good correlation with restriction of retinoic acid receptor β (RARβ) expression in RGCs after birth. Furthermore, we demonstrated that a histone deacetylase inhibitor, trichostatin A, induced axonal regeneration of adult rat RGCs through RARβ induction.
authors.affiliation: Department of Molecular Neurobiology, Graduate School of Medicine, Kanazawa University, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Koriyama
authors.forename: Kayo
authors.initials: K
authors.lastname: Sugitani
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ogai
authors.forename: Satoru
authors.initials: S
authors.lastname: Kato
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000818:Animals; D001369:Axons / Q000502:physiology*; D002478:Cells, Cultured; D015870:Gene Expression / Q000187:drug effects*; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology*; D006657:Histones / Q000378:metabolism*; D006877:Hydroxamic Acids / Q000494:pharmacology*; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects* / Q000235:genetics*; D055495:Neurogenesis / Q000187:drug effects* / Q000235:genetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018168:Receptors, Retinoic Acid / Q000235:genetics* / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism / Q000502:physiology*
chemical_list: D056572:Histone Deacetylase Inhibitors; D006657:Histones; D006877:Hydroxamic Acids; D018168:Receptors, Retinoic Acid; C082925:retinoic acid receptor beta; C012589:trichostatin A