title: New biological treatments for gynecological tumors: focus on angiogenesis.
abstract: BACKGROUND
  Gynecological tumors are a group of heterogeneous malignancies, with only modest results having been observed thus far with chemotherapy in advanced disease. New insights from pathobiology of these tumors have shed new light on potential new therapeutic targets. Angiogenesis is one of the most important processes involved in tumorigenesis, and effective treatments targeting the angiogenic machinery are now available.
  
  
  METHODS
  In this review, we will focus on angiogenesis as a therapeutic target in gynecological cancer patients. After a brief introduction on the angiogenesis machinery involvement in these malignancies, the most recent clinical data will be discussed.
  
  
  CONCLUSIONS
  Although clinical data with antiangiogenics are groundbreaking in several tumors such as ovarian epithelial cancer, overall efficacy of these agents is far from what was initially envisaged. As with other molecular targeted agents, selection of patients who may benefit from these agents will surely contribute to demonstrating better results. However, this does not diminish the clinical relevance of the above-mentioned results in a difficult field such as gynecological malignancies.
authors.affiliation: Istituto Nazionale per lo Studio e la Cura dei Tumori "Fondazione Giovanni Pascale", IRCCS, Clinical Trials Unit , Via M. Semmola, 80131, Napoli , Italy +39 081 593 571 ; +39 081 770 2938 ; f.perrone@istitutotumori.na.it , francesco.perrone@usc-intnapoli.net.
authors.forename: Gennaro
authors.initials: G
authors.lastname: Daniele
authors.forename: Massimo
authors.initials: M
authors.lastname: Di Maio
authors.forename: Maria Carmela
authors.initials: MC
authors.lastname: Piccirillo
authors.forename: Pasqualina
authors.initials: P
authors.lastname: Giordano
authors.forename: Ida
authors.initials: I
authors.lastname: Capuano
authors.forename: Sabrina Chiara
authors.initials: SC
authors.lastname: Cecere
authors.forename: Jane Claire
authors.initials: JC
authors.lastname: Bryce
authors.forename: Sandro
authors.initials: S
authors.lastname: Pignata
authors.forename: Francesco
authors.initials: F
authors.lastname: Perrone
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001688:Biological Products / Q000627:therapeutic use*; D000077216:Carcinoma, Ovarian Epithelial; D002986:Clinical Trials as Topic / Q000639:trends; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000175:diagnosis / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000188:drug therapy*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D020533:Angiogenesis Inhibitors; D001688:Biological Products