title: The effects of resveratrol on chronic constriction injury of sciatic nerve in rats.
abstract: The aim of this study was to investigate the effects of resveratrol (RVT) in chronic constriction injury (CCI) of sciatic nerve by behavioral, histomorphological and immunohistochemical evaluations in rats. In this study, male Wistar rats were divided into three groups: sham (n=7), CCI+saline (n=7) and CCI+RVT (n=7). After inducing CCI, treatment with 10mg/kg/day of RVT or saline for 14 days was given. Locomotor function was assessed with rota-rod and open field tests. Morphologic alterations of sciatic nerve were assessed histologically by light and electron microscopy. Immunohistochemistry for insulin-like growth factor-1 (IGF-1) were performed. RVT treatment prevented motor impairment and histomorphological alterations caused by chronic constriction injury of sciatic nerve. IGF-1 immunoreactivity was significantly higher in RVT treated group then CCI induced group and positive correlated with morphometric parameters. These results indicate that RVT may reduce CCI induced damage and this effect may be mediated through the restoration of IGF-1 immunoreactivity.
authors.affiliation: Department of Histology & Embryology, Dokuz Eylul University Medical School, Balcova, Izmir, Turkey.
authors.forename: H A
authors.initials: HA
authors.lastname: Bagriyanik
authors.affiliation: Department of Histology & Embryology, Dokuz Eylul University Medical School, Balcova, Izmir, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Ersoy
authors.affiliation: Department of Physiology, Dokuz Eylul University Medical School, Balcova, Izmir, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Cetinkaya
authors.affiliation: Dokuz Eylul University Medical School, Balcova, Izmir, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Ikizoglu
authors.affiliation: Dokuz Eylul University Medical School, Balcova, Izmir, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Kutri
authors.affiliation: Dokuz Eylul University Medical School, Balcova, Izmir, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Ozcana
authors.affiliation: Dokuz Eylul University Medical School, Balcova, Izmir, Turkey.
authors.forename: L G
authors.initials: LG
authors.lastname: Kamanga
authors.affiliation: Department of Physiology, Dokuz Eylul University Medical School, Balcova, Izmir, Turkey; Division of Behavioral Physiology, Department of Physiology, Dokuz Eylul University Medical School, Balcova, Izmir, Turkey. Electronic address: muge.kiray@deu.edu.tr.
authors.forename: M
authors.initials: M
authors.lastname: Kiray
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002908:Chronic Disease; D003251:Constriction, Pathologic; D007150:Immunohistochemistry; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology*; D059348:Peripheral Nerve Injuries / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology; D017208:Rats, Wistar; D000077185:Resveratrol; D012584:Sciatic Nerve / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D013267:Stilbenes; D007334:Insulin-Like Growth Factor I; D000077185:Resveratrol
keywords: Chronic constriction injury; Insulin-like growth factor 1; Locomotor function; Morphometry; Rat sciatic nerve; Resveratrol