title: Maintenance of a healthy trajectory of the intestinal microbiome during aging: a dietary approach.
abstract: Sharing an intense transgenomic metabolism with the host, the intestinal microbiota is an essential factor for several aspects of the human physiology. However, several age-related factors, such as changes diet, lifestyle, inflammation and frailty, force the deterioration of this intestinal microbiota-host mutualistic interaction, compromising the possibility to reach longevity. In this scenario, the NU-AGE project involves the development of dietary interventions specifically tailored to the maintenance of a healthy trajectory of the intestinal microbiome, counteracting all processes connected to the pathophysiology of the human aging.
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy. Electronic address: marco.candela@unibo.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Candela
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Biagi
authors.affiliation: Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Brigidi
authors.affiliation: Department of Microbiology & Alimentary Pharmabiotic Centre, University College Cork, Ireland.
authors.forename: Paul W
authors.initials: PW
authors.lastname: O'Toole
authors.affiliation: Laboratory of Microbiology, Wageningen University, The Netherlands, and Departments of Veterinary Biosciences and Bacteriology & Immunology, Helsinki University, Finland.
authors.forename: Willem M
authors.initials: WM
authors.lastname: De Vos
mesh_terms: D000368:Aged; D000375:Aging; D004032:Diet; D005060:Europe; D023281:Genomics; D006262:Health; D006706:Homeostasis; D006801:Humans; D007249:Inflammation; D007422:Intestines / Q000382:microbiology*; D008136:Longevity; D064307:Microbiota; D008954:Models, Biological; D019076:Transgenes
keywords: Diet; Frailty; Healthy aging; Inflammation; Intestinal microbiota