title: Disposable gendine antimicrobial gloves for preventing transmission of pathogens in health care settings.
abstract: BACKGROUND
  Transmission of organisms by contact of gloves with surfaces following contact with a pathogen source has been recognized as an important vector for pathogenesis of health care-associated infections. In these cases, the gloves protect the wearer from contact with the pathogenic organisms; however, this personal protection can facilitate the wearer unwittingly becoming a carrier of the pathogens from one location to another. A novel gendine (combination of chlorhexidine and gentian violet) antiseptic coating for the external surface of the glove was developed as a potential intervention to prevent this mode of transmission.
  
  
  METHODS
  We characterized the ability of the coating to rapidly kill bacterial and fungal pathogens within 1 minute of contact with the glove surface. The International Organization of Standardization 22196 concentrated inoculum contact testing methodology was followed.
  
  
  RESULTS
  The gendine-coated gloves were able to fully eradicate multidrug-resistant organisms included methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterocci, multidrug-resistant Pseudomonas aeruginosa, and Klebsiella pneumoniae carbapenemase producing. In addition, Candida albicans, Candida glabarata, and 2 pathogenic Escherichia coli strains commonly associated with invasive gastroenteritis were also fully eradicated within 1 minute of contact. The gendine coating did not adversely impact the finish or integrity of the disposable gloves.
  
  
  CONCLUSIONS
  The highly efficacious gendine-coated antimicrobial gloves potentially provide an additional means of protection against horizontal transmission of common pathogens in a hospital setting.
authors.affiliation: Department of Infectious Disease, Infection Control, Employee Health, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Ruth
authors.initials: R
authors.lastname: Reitzel
authors.affiliation: Department of Infectious Disease, Infection Control, Employee Health, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: jsrosenblatt@mdanderson.org.
authors.forename: Joel
authors.initials: J
authors.lastname: Rosenblatt
authors.affiliation: Department of Infectious Disease, Infection Control, Employee Health, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Infectious Disease, Infection Control, Employee Health, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Ray
authors.initials: R
authors.lastname: Hachem
authors.affiliation: Department of Infectious Disease, Infection Control, Employee Health, University of Texas MD Anderson Cancer Center, Houston, TX.
authors.forename: Issam
authors.initials: I
authors.lastname: Raad
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002710:Chlorhexidine / Q000494:pharmacology; D003428:Cross Infection / Q000517:prevention & control* / Q000635:transmission; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D004209:Disposable Equipment; D005658:Fungi / Q000187:drug effects; D005840:Gentian Violet / Q000494:pharmacology; D017575:Gloves, Protective; D006801:Humans; D017053:Infection Control / Q000379:methods*; D050296:Microbial Viability / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D005840:Gentian Violet; D002710:Chlorhexidine
keywords: Antiseptic; Health care-associated infections; Horizontal transmission; Multidrug resistant