title: GABAergic dysfunction in pediatric neuro-developmental disorders.
abstract: The GABAergic system is central to the development and functional maturation of the nervous system. Emerging evidence support the role of GABAergic dysfunction in neuro-developmental disorders. This review presents the molecules and mechanisms that underlie GABA system dysfunction in several neuro-developmental disorders presenting in childhood. The impact on synaptic plasticity, neuronal circuit function and behavior, followed by targeted treatment strategies are discussed.
authors.affiliation: Neurology, Kennedy Krieger Institute Baltimore, MD, USA ; Neurology, Johns Hopkins School of Medicine Baltimore, MD, USA.
authors.forename: Constance L
authors.initials: CL
authors.lastname: Smith-Hicks
keywords: PV interneurons; circuits; critical period; disease; synaptic plasticity