title: CD157 at the intersection between leukocyte trafficking and epithelial ovarian cancer invasion.
abstract: CD157 is a member of the ADP-ribosyl cyclase gene family that is involved in the metabolism of NAD. CD157 behaves both as an ectoenzyme and as a receptor. Though CD157 is anchored to the membrane by a glycosylphosphatidylinositol moiety, which makes it unsuitable to transduce signals on its own, it exploits its localization in selected membrane microdomains and its proclivity to interact with integrins to accomplish receptor functions. Initially characterized as a stromal and myeloid antigen involved in the control of leukocyte adhesion, migration and diapedesis, CD157 was subsequently found to have a far wider distribution. In particular, CD157 was found to be expressed by epithelial ovarian cancer cells where it is involved in interactions among tumor cells, extracellular matrix proteins and mesothelium. The overall picture inferred from experimental and clinical observations is that CD157 is a critical player both in leukocyte trafficking and in ovarian cancer invasion and metastasis formation. In this review, we will discuss the biological mechanisms underpinning the role of CD157 in the control of leukocyte migration and ovarian cancer dissemination.
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
authors.forename: Nicola
authors.initials: N
authors.lastname: Lo Buono
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Morone
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
authors.forename: Alice
authors.initials: A
authors.lastname: Giacomino
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
authors.forename: Rossella
authors.initials: R
authors.lastname: Parrotta
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
authors.forename: Enza
authors.initials: E
authors.lastname: Ferrero
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Malavasi
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
authors.forename: Erika
authors.initials: E
authors.lastname: Ortolan
authors.affiliation: Laboratory of Immunogenetics, Department of Medical Sciences, University of Torino, Via Santena 19, 10126 Torino, Italy.
authors.forename: Ada
authors.initials: A
authors.lastname: Funaro
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology*; D005260:Female; D058851:GPI-Linked Proteins / Q000276:immunology; D006801:Humans; D007962:Leukocytes / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009375:Neoplasms, Glandular and Epithelial / Q000276:immunology / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D036541:ADP-ribosyl Cyclase; C087521:ADP-ribosyl cyclase 2