title: Post-vaccine glomerulonephritis in an infant with hereditary C2 complement deficiency: case study.
abstract: We describe a case of a post vaccine immune complex-mediated glomerulonephritis in an infant with compound heterozygous mutations of C2 complement component gene, which is the first such case in the literature. The three and a half months old boy presented with clinical and laboratory signs of nephritic syndrome and was successfully treated with methylprednisolone. An explanation of such a clinical picture may lie in the interaction between C2 deficiency and vaccination.
authors.affiliation: Tanja Kersnik Levart, Department of Pediatric Nephrology, University Medical Centre, Bohoriceva 20, 1000 Ljubljana, Slovenia, tanja.kersnik@guest.arnes.si.
authors.forename: Tanja
authors.initials: T
authors.lastname: Kersnik Levart
mesh_terms: D000936:Antigen-Antibody Complex / Q000276:immunology*; D003175:Complement C2 / Q000172:deficiency* / Q000235:genetics; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D014611:Vaccination / Q000009:adverse effects*
chemical_list: D000936:Antigen-Antibody Complex; D003175:Complement C2; D008775:Methylprednisolone