title: [Study on propofol and fentanyl administrated via common carotid artery in rabbits].
abstract: OBJECTIVE
  To compare the pharmacodynamic differences of common carotid artery administration with ear vein administration of propofol and fentanyl in rabbits.
  
  
  METHODS
  Sixty New Zealand white rabbits were randomly divided into four groups(n = 15):PvFv, PvFa, PaFv and PaFa groups. Propofol 30 mg×kg(-1)×h(-1) and fentanyl 2 µg×kg(-1)×h(-1)were administrated via the ear vein or the common carotid artery. The outcomes were recorded, including the time of consciousness loss and recovery, to electrocerebral silence, dose of propofol and fentanyl, mean arterial pressure, heart rate, respiration rate and SpO2.
  
  
  RESULTS
  (1) None of rabbits appeared breathing to be depressed seriously in group PaFa, while respiratory in the other groups were significantly depressed. (2) The dosage of propofol and fentanyl of group PaFa was significantly less than the other groups (P < 0.05). (3) The time of consciousness loss and recovery of group PaFa were shorter than the other three groups.
  
  
  CONCLUSIONS
  Compared to drugs infusion via the ear vein, infusion of propol and fentanyl via the common carotid artery is more advantageous in some aspects, such as rapid anesthesia induction and recovery, smaller dose, and smaller impact on the hemodynamic and respiratory.
authors.affiliation: Department of Anesthesiology, Hebei Medical University, Shijiazhuang 050051, China.
authors.forename: Zhi-hua
authors.initials: ZH
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Hebei Medical University, Shijiazhuang 050051, China.
authors.forename: Fu-qiang
authors.initials: FQ
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Hebei Medical University, Shijiazhuang 050051, China.
authors.forename: Guan-jie
authors.initials: GJ
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, Hebei Medical University, Shijiazhuang 050051, China. Email:mzlzh2013@163.com.
authors.forename: Shun-suo
authors.initials: SS
authors.lastname: Liu
mesh_terms: D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous; D000818:Animals; D017536:Carotid Artery, Common; D004569:Electroencephalography; D005240:Feasibility Studies; D005283:Fentanyl / Q000008:administration & dosage*; D015742:Propofol / Q000008:administration & dosage*; D011817:Rabbits
chemical_list: D018686:Anesthetics, Intravenous; D005283:Fentanyl; D015742:Propofol