title: Treatment of cancer in a child with ocular xeroderma pigmentosa (XP) in Malawi.
abstract: A 3-year-old girl presented to the Eye Hospital, Blantyre, Malawi, with multiple ulcerating lesions on her face and in her eyes. Her skin was freckled, with hypopigmented and hyperpigmented areas (poikilodermia) typical of xeroderma pigmentosa. The tumors on the conjunctiva of the right eye and the lower eyelid of the left eye appeared to be squamous cell carcinomas. Chemotherapy with intravenous 5-flourouracil (1000 mg/m) for 5 days and cisplatin (50 mg/m) for 2 days for 3 cycles every 3 weeks was well tolerated. Good response occurred after 1 cycle and after 2 more courses the tumors had resolved.
authors.forename: Markus
authors.initials: M
authors.lastname: Schulze Schwering
authors.affiliation: *Department of Ophthalmology, College of Medicine ‡Department of Pediatric Oncology, College of Medicine, University of Malawi, Blantyre, Malawi †University Eye Hospital Tübingen, Tübingen, Germany.
authors.forename: Markus S
authors.initials: MS
authors.lastname: Schwering
authors.forename: George
authors.initials: G
authors.lastname: Chagaluka
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Molyneux
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000188:drug therapy / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D002675:Child, Preschool; D002945:Cisplatin / Q000627:therapeutic use*; D005142:Eyelid Neoplasms / Q000188:drug therapy / Q000473:pathology; D005153:Facial Neoplasms / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D008295:Malawi; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy* / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014983:Xeroderma Pigmentosum / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000964:Antimetabolites, Antineoplastic; D002945:Cisplatin; D005472:Fluorouracil