title: Evaluation of the wound-healing effect of a novel Hypericum perforatum ointment in skin injury.
abstract: The present experiment aims to formulate and characterize a new phytotherapy ointment based on a total extract of Hypericum perforatum included in a novel ointment base. In order to investigate the healing properties of the ointment, in vivo experimental wound models of linear incision, circular excision and thermal burn were performed on Wistar rats. Topical treatment was achieved daily, for 21 days. Clinical and macroscopic evaluation, determination of wound contraction rate, period of re-epithelialization, and histopathological examination were achieved, along with the determination of the particle diameter and particle size distribution of the ointment. The results demonstrate that the tested novel ointment has significant wound healing effect in skin injuries and reveals to be safe for use.
authors.affiliation: Discipline of Anatomy and Embryology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, Iassy, Romania; dr_anca_sava@yahoo.com.
authors.forename: Anca Irina
authors.initials: AI
authors.lastname: Prisăcaru
authors.forename: C V
authors.initials: CV
authors.lastname: Andriţoiu
authors.forename: Corina
authors.initials: C
authors.lastname: Andriescu
authors.forename: E C
authors.initials: EC
authors.lastname: Hăvârneanu
authors.forename: M
authors.initials: M
authors.lastname: Popa
authors.forename: A G M
authors.initials: AG
authors.lastname: Motoc
authors.forename: Anca
authors.initials: A
authors.lastname: Sava
mesh_terms: D000818:Animals; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D020902:Hypericum / Q000737:chemistry*; D007834:Lasers; D008297:Male; D009824:Ointments / Q000494:pharmacology*; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects / Q000293:injuries* / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D009824:Ointments