title: Combined corticospinal and reticulospinal effects on upper limb muscles.
abstract: Both the reticulospinal and corticospinal systems are known to control recruitment of upper limb muscles, yet no known studies have attempted to assess their combined effects in the same experiment in the awake, behaving primate. The purpose of this study is to present an approach for the analysis of the cooperative control from these two motor systems. Muscle responses to electrical stimulation in the reticulospinal system and corticospinal system alone or in combination were studied. The responses were categorized based on simple neural circuits that could explain the interactions of these systems. Five such circuits were identified that could explain 86% of the observed patterns of combined recruitment during stimulation. Improved understanding of the cooperation between these motor systems could provide insight for development of better rehabilitation approaches for stroke patients and others with movement disorders.
authors.affiliation: School of Health and Rehabilitation Sciences, Physical Therapy Division, The Ohio State University, Columbus, OH, United States; Biomedical Engineering, The Ohio State University, Columbus, OH, United States.
authors.forename: Alexis
authors.initials: A
authors.lastname: Ortiz-Rosario
authors.affiliation: Biomedical Engineering, The Ohio State University, Columbus, OH, United States.
authors.forename: Ioannisely
authors.initials: I
authors.lastname: Berrios-Torres
authors.affiliation: Biomedical Engineering, The Ohio State University, Columbus, OH, United States.
authors.forename: Hojjat
authors.initials: H
authors.lastname: Adeli
authors.affiliation: School of Health and Rehabilitation Sciences, Physical Therapy Division, The Ohio State University, Columbus, OH, United States; Biomedical Engineering, The Ohio State University, Columbus, OH, United States; Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, OH, United States. Electronic address: buford.5@osu.edu.
authors.forename: John A
authors.initials: JA
authors.lastname: Buford
mesh_terms: D000818:Animals; D004525:Efferent Pathways / Q000502:physiology; D008252:Macaca fascicularis; D008297:Male; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D011712:Pyramidal Tracts / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology*; D034941:Upper Extremity / Q000294:innervation / Q000502:physiology*
keywords: Corticospinal system; Electrical stimulation; Neural circuits; Reticulospinal system; Upper limb