title: Beneficial effects of mangiferin isolated from Salacia chinensis on biochemical and hematological parameters in rats with streptozotocin-induced diabetes.
abstract: Salacia chinensis L. is a traditional Southeast Asian herbal medicine and used in the treatment of diabetes. To investigate the antidiabetic properties of mangiferin from Salacia chinensis and its beneficial effect on toxicological and hematological parameters in streptozotocin induced diabetic rats. Mangiferin was orally treated with the dose of 40 mg/kg body weight/day for 30 days to diabetic rats. Biochemical (blood glucose, uric acid, urea and creatinine), toxicological (AST, ALT and ALP) and hematological parameters (red and white blood cells) and their functional indices were evaluated in diabetic treated groups with mangiferin and glibenclamide. Mangiferin treated diabetic rats significantly (p<0.05) lowered the level of blood glucose, in addition, altered the levels of biochemical parameters including urea, uric acid, and creatinine. Toxicological parameters including AST, ALT and ALP were also significantly reduced after treatment with mangiferin in diabetic rats. Similarly, the levels of red blood, white blood cells and their functional indices were significantly improved through the administration of mangiferin. Thus, our results indicate that mangiferin present in S. chinensis possesses antidiabetic properties and nontoxic nature against chemically induced diabetic rats. Further experimental investigations are warrant to make use of its relevant therapeutic effect to substantiate its ethno-medicinal usage.
authors.affiliation: Lab No.102, Centre for Advanced studies in Botany, University of Madras, Chennai, Tamilnadu, India/Department of Food Process Engineering, School of Bio-Engineering, SRM University, Kattankulathur, Tamilnadu, India.
authors.forename: Periyar Selvam
authors.initials: PS
authors.lastname: Sellamuthu
authors.affiliation: Laboratory of Vaccines & Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Arulselvan
authors.affiliation: Laboratory of Vaccines & Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia.
authors.forename: Sharida
authors.initials: S
authors.lastname: Fakurazi
authors.affiliation: Lab No.102, Centre for Advanced studies in Botany, University of Madras, Chennai, Tamilnadu, India.
authors.forename: Murugesan
authors.initials: M
authors.lastname: Kandasamy
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D051381:Rats; D017208:Rats, Wistar; D049918:Salacia / Q000737:chemistry*; D013311:Streptozocin; D014527:Uric Acid / Q000097:blood; D044004:Xanthones / Q000627:therapeutic use*
chemical_list: D001786:Blood Glucose; D044004:Xanthones; C013592:mangiferin; D014527:Uric Acid; D013311:Streptozocin; D003404:Creatinine