title: Synthesis and antimicrobial activity of (1,4-phenylene)bis(arylsulfonylpyrazoles and isoxazoles).
abstract: A new class of (1,4-phenylene)bis(arylsufonylpyrazoles and isoxazoles) were synthesized by 1,3-dipolar cycloaddition of nitrile imines and nitrile oxides to the 1,4-bis((E)-2-(arylsulfonyl)vinyl)benzenes in the presence of chloramine-T. Compound 7f exhibited pronounced antimicrobial activity.
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: G
authors.initials: G
authors.lastname: Lavanya
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: L
authors.initials: L
authors.lastname: Mallikarjuna Reddy
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India.
authors.forename: V
authors.initials: V
authors.lastname: Padmavathi
authors.affiliation: Department of Chemistry, Sri Venkateswara University, Tirupati 517 502, Andhra Pradesh, India. Electronic address: adivireddyp@yahoo.co.in.
authors.forename: A
authors.initials: A
authors.lastname: Padmaja
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects / Q000254:growth & development; D061565:Cycloaddition Reaction; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000254:growth & development; D007097:Imines / Q000737:chemistry; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D010408:Penicillium chrysogenum / Q000187:drug effects / Q000254:growth & development; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007097:Imines; D007555:Isoxazoles; D009570:Nitriles; D010087:Oxides; D011720:Pyrazoles
keywords: Antimicrobial activity; Bis(isoxazoles); Bis(pyrazoles); Nitrile imines; Nitrile oxides