title: [Multicenter randomized clinical study of high-intensity focused ultrasound and cortical hormone in the treatment of non-neoplastic epithelial disorders of vulva].
abstract: OBJECTIVE
  To evaluate the efficacy of high-intensity focused ultrasound (HIFU) and cortical hormone in the treatment of non-neoplastic epithelial disorders of vulva.
  
  
  METHODS
  A total of 268 cases with pathologically diagnosed non-neoplastic epithelial disorders of vulva were randomly allocated into two groups of high-intensity focused ultrasound (HIFU) (n = 119) and cortical hormone (n = 124). And 25 cases became lost to follow-ups. Their signs, symptoms and quality-of-life were assessed before treatment, 1 month post-treatment and 3 months post-treatment. And the relationship was analyzed between pathologic type, age, course and efficacies.
  
  
  RESULTS
  Their signs, symptoms and quality-of-life improved in both groups after 1 and 3 month. Compared with drug therapy, HIFU showed superior results in lesion amelioration at 1 month with significantly statistical difference and so did lesion amelioration and therapeutic effect at 3 month. And the efficacy of HIFU was better in those with >10-year disease course and pathologically diagnosed lichen sclerosus in 3 months.
  
  
  CONCLUSIONS
  HIFU is both safe and effective in the treatment of non-neoplastic epithelial disorders of vulva.
authors.affiliation: Department of Obstetrics & Gynecology, Peking Union Medical College Hospital & Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Hong-hui
authors.initials: HH
authors.lastname: Shi
authors.affiliation: Email: zhu_julie@sina.com.
authors.forename: Lan
authors.initials: L
authors.lastname: Zhu
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Hang-mei
authors.initials: HM
authors.lastname: Jin
authors.forename: Rui-zhen
authors.initials: RZ
authors.lastname: Li
authors.forename: Zhi-qing
authors.initials: ZQ
authors.lastname: Liang
authors.forename: Jing-he
authors.initials: JH
authors.lastname: Lang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006206:Halcinonide / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000379:methods; D014845:Vulvar Diseases / Q000628:therapy*; D055815:Young Adult
chemical_list: D006206:Halcinonide