title: Nodal Melanoma Metastasis under Infliximab Therapy in a Patient with Nevoid Melanoma First Misdiagnosed as Benign Nevus: A Potentially Dangerous Diagnostic Pitfall in the Era of Biologic Therapies.
abstract: We report the case of a 53-year-old Caucasian woman who developed nodal melanoma metastasis under infliximab therapy 2 years after the removal of a nevoid melanoma, which was initially misdiagnosed as a benign compound nevus. This case illustrates the potential link between tumor necrosis factor (TNF)-α inhibition and the reactivation of latent melanoma. Furthermore, this case highlights the need for a complete skin examination before using anti-TNF-α therapy to rule out atypical malignant lesions or melanomas that can easily be missed because of presentations such as nevoid melanoma.
authors.affiliation: Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Safa
authors.affiliation: Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Fromentoux
authors.affiliation: Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
authors.forename: Laure
authors.initials: L
authors.lastname: Darrieux
authors.affiliation: Armor Pathology Laboratory, Plérin, France.
authors.forename: Jean-Anastase
authors.initials: JA
authors.lastname: Hogenhuis
authors.affiliation: Armor Pathology Laboratory, Plérin, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Tisseau
keywords: Diagnostic pitfalls; Infliximab; Metastasis; Nevoid melanoma; Tumor necrosis factor-α