title: Markers of epithelial-mesenchymal transition in renal cell carcinoma.
abstract: OBJECTIVE
  To study the influence of markers of epithelial-mesenchymal transition (EMT) on a renal cell carcinoma (RCC) prognosis.
  
  
  METHODS
  The surgical material of 47 RCC patients who underwent nephrectomy was studied. RCC patients were distributed in two groups: a short-term survival group (3-6 months) and a long-term survival group (17-24 months). EMT markers expression was assessed by immunohistochemical methods.
  
  
  RESULTS
  It was determined that the rate of spindle-cell EMT was 96.4% in a short-term survival group and 42.1% in a long-term survival group. High rate Furhman's nuclear atypia, i.e. degree 3-4 occurred in 100% of cases in a short-term survival group versus 68.4% in a long-term survival group.
  
  
  CONCLUSIONS
  The rate of spindle-cell EMT in RCC may serve a more sensible prognostic factor than the degree of Furhman's nuclear atypia.
authors.affiliation: Department of Oncology, Maksim Gorky National Medical University, Donetsk 83092, Ukraine.
authors.forename: Y V
authors.initials: YV
authors.lastname: Dumanskiy
authors.affiliation: Department of Oncology, Maksim Gorky National Medical University, Donetsk 83092, Ukraine.
authors.forename: A G
authors.initials: AG
authors.lastname: Kudriashov
authors.affiliation: Department of Pathology, Maksim Gorky National Medical University, Donetsk 83003, Ukraine.
authors.forename: I V
authors.initials: IV
authors.lastname: Vasilenko
authors.affiliation: Department of Pathology, Maksim Gorky National Medical University, Donetsk 83003, Ukraine.
authors.forename: R B
authors.initials: RB
authors.lastname: Kondratyuk
authors.affiliation: Department of Pathology, Maksim Gorky National Medical University, Donetsk 83003, Ukraine.
authors.forename: Y K
authors.initials: YK
authors.lastname: Gulkov
authors.affiliation: Donetsk Regional Anticancer Center, Donetsk 83092, Ukraine.
authors.forename: R S
authors.initials: RS
authors.lastname: Cyrillichystiakov
mesh_terms: D014408:Biomarkers, Tumor; D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000473:pathology*; D060787:Neoplasm Grading
chemical_list: D014408:Biomarkers, Tumor