title: hTERT deficiency in naïve T cells affects lymphocyte homeostasis in myelodysplastic syndrome patients.
abstract: Myelodysplastic syndromes (MDSs) are hematopoietic stem cell disorders with a high potential to develop into acute myeloid leukemia (AML). We have recently demonstrated that naïve T cells, but not memory T cells, from MDS patients exhibit a pronounced deficiency in the mRNA coding for the catalytic subunit of telomerase (hTERT). We discuss the importance of this finding for lymphocytic homeostasis in MDS patients.
authors.affiliation: Department of Immunology; Tianjin Cancer Institute and Hospital; Tianjin Medical University; Tianjin, China ; Key Laboratory of Cancer Immunology and Biotherapy; Tianjin, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Yang
authors.affiliation: Immunology Program at the H. Lee Moffitt Cancer Center; Tampa, FL USA.
authors.forename: Erika A
authors.initials: EA
authors.lastname: Eksioglu
authors.affiliation: Immunology Program at the H. Lee Moffitt Cancer Center; Tampa, FL USA.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wei
keywords: T lymphocyte; bone marrow failure; myelodysplastic syndrome; telomere