title: Magnolia extract (BL153) ameliorates kidney damage in a high fat diet-induced obesity mouse model.
abstract: Accumulating evidence demonstrated that obesity is a risk factor for renal structural and functional changes, leading to the end-stage renal disease which imposes a heavy economic burden on the community. However, no effective therapeutic method for obesity-associated kidney disease is available. In the present study, we explored the therapeutic potential of a magnolia extract (BL153) for treating obesity-associated kidney damage in a high fat diet- (HFD-) induced mouse model. The results showed that inflammation markers (tumor necrosis factor- α and plasminogen activator inhibitor-1) and oxidative stress markers (3-nitrotyrosine and 4-hydroxy-2-nonenal) were all significantly increased in the kidney of HFD-fed mice compared to mice fed with a low fat diet (LFD). Additionally, proteinuria and renal structure changes in HFD-fed mice were much more severe than that in LFD-fed mice. However, all these alterations were attenuated by BL153 treatment, accompanied by upregulation of peroxisome proliferator-activated receptor- γ coactivator-1 α (PGC-1 α ) and hexokinase II (HK II) expression in the kidney. The present study indicates that BL153 administration may be a novel approach for renoprotection in obese individuals by antiinflammation and anti-oxidative stress most likely via upregulation of PGC-1 α and HK II signal in the kidney.
authors.affiliation: The Second Hospital of Jilin University, Changchun 130041, China ; The Kosair Children's Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA.
authors.forename: Wenpeng
authors.initials: W
authors.lastname: Cui
authors.affiliation: The Second Hospital of Jilin University, Changchun 130041, China ; The Kosair Children's Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA.
authors.forename: Yangwei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The Kosair Children's Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA ; School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Chen
authors.affiliation: The Kosair Children's Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA ; The First Hospital of Jilin University, Changchun 130021, China.
authors.forename: Weixia
authors.initials: W
authors.lastname: Sun
authors.affiliation: The Kosair Children's Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Cai
authors.affiliation: The Kosair Children's Hospital Research Institute, Department of Pediatrics of the University of Louisville, Louisville, KY 20202, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tan
authors.affiliation: Bioland Biotec Co., Ltd., Zhangjiang Modern Medical Device Park, Pudong, Shanghai 201201, China.
authors.forename: Ki-Soo
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Bioland R&D Center, 59 Songjeongni 2-gil, Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea.
authors.forename: Ki Ho
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Bioland R&D Center, 59 Songjeongni 2-gil, Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea.
authors.forename: Young Heui
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D059305:Diet, High-Fat; D004195:Disease Models, Animal; D006593:Hexokinase / Q000378:metabolism; D007249:Inflammation / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology; D007677:Kidney Function Tests; D031566:Magnolia / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D009765:Obesity / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects; D047495:PPAR gamma / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use; D015854:Up-Regulation / Q000187:drug effects
chemical_list: C000593973:BL153 extract; D047495:PPAR gamma; D010936:Plant Extracts; D020011:Protective Agents; D016660:NAD(P)H Dehydrogenase (Quinone); C491732:Nqo1 protein, mouse; D006593:Hexokinase