title: A selective molecularly imprinted polymer-carbon nanotube sensor for cotinine sensing.
abstract: Conductive composite films comprised of single-walled carbon nanotubes coated with molecularly imprinted poly-4-vinylphenol are produced and characterized using ultraviolet and infrared spectroscopies, confirming the successful molecular imprinting of the film with cotinine. The electrical resistance of the imprinted film changes significantly upon binding cotinine, by more than 30 kΩ, while the unimprinted film in comparison elicits little response. Additionally, once the cotinine template desorbs from the film, the resistance of the imprinted film returns to a value close to the pre-adsorption baseline. Scanning electron microscopy is used to study the morphology of the film compared with the unimprinted control, and gas chromatography quantitatively confirms that the imprinted film selectively detects cotinine while discriminating against the structurally similar alkaloid, nicotine.
authors.affiliation: Department of Chemistry, Dartmouth College, Hanover, NH, 03755, USA.
authors.forename: Sadik
authors.initials: S
authors.lastname: Antwi-Boampong
authors.forename: Kristina S
authors.initials: KS
authors.lastname: Mani
authors.forename: Jean
authors.initials: J
authors.lastname: Carlan
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: BelBruno
mesh_terms: D000327:Adsorption; D015374:Biosensing Techniques / Q000379:methods*; D002849:Chromatography, Gas; D003367:Cotinine / Q000032:analysis*; D004563:Electrochemistry; D008855:Microscopy, Electron, Scanning; D054802:Molecular Imprinting; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D037742:Nanotubes, Carbon; D010636:Phenols; D011108:Polymers; D003367:Cotinine; C030626:4-vinylphenol
keywords: carbon nanotube composite; conductive sensor; cotinine; molecularly imprinted polymer; poly-4-vinylphenol; thin films