title: Quality control of positron emission tomography radiopharmaceuticals: An institutional experience.
abstract: OBJECTIVE
  To study quality control parameters of routinely prepared positron emission tomography (PET) radiopharmaceuticals.
  
  
  METHODS
  Three PET radiopharmaceuticals fluorine-18 fluorodeoxyglucose (F-18 FDG), N-13 ammonia (N-13 NH3), and Ga-68 DOTATATE (n = 25 each), prepared by standardized protocols were used. The radionuclide purity, radiochemical purity, residual solvents, pH, endotoxins, and sterility of these radiopharmaceuticals were determined.
  
  
  RESULTS
  The physical half-life of radionuclide in radiopharmaceuticals, determined by both graphical and formula method, demonstrated purity of radionuclides used. pH of all PET radiopharmaceuticals used was in the range of 5-6.5. No microbial growth was observed in radiopharmaceutical preparations. The residual solvents, chemical impurity, and pyrogens were within the permissible limits.
  
  
  CONCLUSIONS
  All three PET radiopharmaceuticals were safe for intravenous administration.
authors.affiliation: Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
authors.forename: Jaya
authors.initials: J
authors.lastname: Shukla
authors.affiliation: Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
authors.forename: Rakhee
authors.initials: R
authors.lastname: Vatsa
authors.affiliation: Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
authors.forename: Nitasha
authors.initials: N
authors.lastname: Garg
authors.affiliation: Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
authors.forename: Priya
authors.initials: P
authors.lastname: Bhusari
authors.affiliation: Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
authors.forename: Ankit
authors.initials: A
authors.lastname: Watts
authors.affiliation: Department of Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India.
authors.forename: Bhagwant R
authors.initials: BR
authors.lastname: Mittal
keywords: Gas chromatography; half-life; multichannel analyzer; pyrogen; sterility