title: Salt as a catalyst in the mitochondria: returning cytochrome c to its native state after it misfolds on the surface of cardiolipin containing membranes.
abstract: Cytochrome c binding to cardiolipin receptors on the surface of TOCL/DOPC(20% : 80%) liposomes induces a conformational change, which is not reversible after the protein's dissociation at low ionic strength. Addition of 100 mM NaCl switches the protein back to its native state.
authors.affiliation: Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, PA, USA. rschweitzer-stenner@drexel.edu.
authors.forename: Leah A
authors.initials: LA
authors.lastname: Pandiscia
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schweitzer-Stenner
mesh_terms: D002308:Cardiolipins / Q000737:chemistry*; D002384:Catalysis; D002462:Cell Membrane; D045304:Cytochromes c / Q000737:chemistry*; D008081:Liposomes; D008928:Mitochondria; D010713:Phosphatidylcholines / Q000737:chemistry*; D017510:Protein Folding; D012965:Sodium Chloride / Q000737:chemistry*
chemical_list: C519576:1,1',2,2'-tetraoleoylcardiolipin; D002308:Cardiolipins; D008081:Liposomes; D010713:Phosphatidylcholines; D012965:Sodium Chloride; D045304:Cytochromes c; C017251:1,2-oleoylphosphatidylcholine