title: [Therapeutic strategy for neuroendocrine tumor of the rectum].
abstract: The clinicopathological features of neuroendocrine tumor (NET) of the rectum were retrospectively analyzed in 25 patients( 17 men and 8 women; mean age, 57 years[ 30-78 years]) at Tohoku University Hospital from January 1998 to December 2012. The average diameter of 25 tumors was 15 mm (5-70 mm). Local resections and rectal resections with lymph node dissection were performed in 16 and 9 tumors, respectively. Three of the 9 tumors had lymph node metastases (33%), including 2 tumors with a diameter of 10 mm. In a median follow-up of 48 months, tumor recurrence was observed in 3 of 25 patients( 12%); local recurrence was observed in 1 patient; and liver metastasis was observed in 2 patients. Of the 2 patients with liver metastasis, liver metastasis recurred in a patient whose primary tumor, with a diameter of 10 mm, had been locally resected 40 months ago. According to histopathological analysis, 3 primary tumors with local recurrence or liver metastasis were categorized as G2 or G3 according to the World Health Organization (WHO) classification. Tumors with a diameter of ≥10 mm, in principle, may be removed by rectal resection with lymph node dissection. However, histopathological findings such as a proliferation of tumor cells should also be taken into consideration when deciding the treatment strategy for rectal NET.
authors.affiliation: Division of Gastrointestinal Surgery, Tohoku University Graduate School of Medicine.
authors.forename: Shinobu
authors.initials: S
authors.lastname: Ohnuma
authors.forename: Takeshi
authors.initials: T
authors.lastname: Naitoh
authors.forename: Sho
authors.initials: S
authors.lastname: Haneda
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Kudoh
authors.forename: Atushi
authors.initials: A
authors.lastname: Kohyama
authors.forename: Munenori
authors.initials: M
authors.lastname: Nagao
authors.forename: Naoki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sasaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Aoki
authors.forename: Tomoya
authors.initials: T
authors.lastname: Abe
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Musha
authors.forename: Takanori
authors.initials: T
authors.lastname: Morikawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Motoi
authors.forename: Yu
authors.initials: Y
authors.lastname: Katayose
authors.forename: Chikashi
authors.initials: C
authors.lastname: Shibata
authors.forename: Michiaki
authors.initials: M
authors.lastname: Unno
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000601:surgery*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D012008:Recurrence