title: Lack of evidence for predictive and prognostic value of cyclin D1 gene polymorphism CCND1 G870A for oral squamous cell carcinoma.
abstract: OBJECTIVE
  Cyclin D1 gene (CCND1) has a G to A polymorphism at the splice donor site of exon 4, position 870. The A allele codes for a truncated variant, cyclin D1b, which may have higher transforming activity. Data regarding the predictive and prognostic value of the CCND1 G870A polymorphism in tumors are controversial. We aimed to examine this polymorphism in patients with oral carcinoma.
  
  
  METHODS
  Genotyping of CCND1 G870A was determined by means of direct sequencing in 83 patients with oral carcinomas and in 102 healthy controls. Association with clinical outcomes was evaluated statistically.
  
  
  RESULTS
  We failed to find any significant association of CCND1 G870A with risk of oral carcinomas in this German population, with clinical and pathological features of the tumours or with overall survival of the patients.
  
  
  CONCLUSIONS
  Our results suggest that CCND1 G870A has no, or only very limited, predictive and prognostic value for oral carcinoma.
authors.affiliation: DMD, Department of Oral Maxillofacial Surgery, Building O10, University Medical Center Hamburg-Eppendorf, Martinistr. 52, D-20246 Hamburg, Germany. r.friedrich@uke.de.
authors.forename: Artun
authors.initials: A
authors.lastname: Atac
authors.forename: Björn
authors.initials: B
authors.lastname: Riecke
authors.forename: Alexandre T
authors.initials: AT
authors.lastname: Assaf
authors.forename: Alexander
authors.initials: A
authors.lastname: Gröbe
authors.forename: Reinhard E
authors.initials: RE
authors.lastname: Friedrich
authors.forename: Max
authors.initials: M
authors.lastname: Heiland
authors.forename: Jakob R
authors.initials: JR
authors.lastname: Izbicki
authors.forename: Lan
authors.initials: L
authors.lastname: Kluwe
authors.forename: Marco
authors.initials: M
authors.lastname: Blessmann
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D016022:Case-Control Studies; D019938:Cyclin D1 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000401:mortality* / Q000473:pathology; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D015996:Survival Rate
chemical_list: C530104:CCND1 protein, human; D019938:Cyclin D1
keywords: CCND1 polymorphism G870A; OSCC; prognostic marker