title: Renal cell carcinoma with venous neoplastic thrombosis: a ten years review.
abstract: OBJECTIVE
  To review the 10-year experience of our urological unit in the surgical management of renal cell carcinoma (RCC) with neoplastic tumor thrombosis focusing on postoperative survival.
  
  
  METHODS
  We underwent a retrospective analysis of the patients treated for this pathology during the last decade 2002-2012, stratifying them by tumor thrombus level and histological subtype. Kaplan-Meyer curves were used to assess survival.
  
  
  RESULTS
  Overall, 67 patients underwent surgery for RCC with neoplastic tumoral thrombosis in the period under review. 60 were clear cell RCC, 4 were urothelial papillary tumors of the renal pelvis and 3 were rare histotypes, as a nefroblastoma, a spinocellular tumor of the renal pelvis and an unclassifiable renal carcinoma. Thrombus level was I in 40 cases, II in 17, III in 2 and IV in 8 patients. We report the main postoperative complications and our survival data, with mean follow up of 36 months. Tumor stage is the most important variable in predicting survival. Patients with N0M0 disease had 70% survival at 36 months, instead of 20% for those with primitive metastatic tumor.
  
  
  CONCLUSIONS
  Our survival results fit with the main reports in literature and our surgical management was completely in keeping with international guidelines. We did not observe relevany post-operative complications, except of hemorrhagic ones that occurred in 6 patients (9% of total) and were always successfully managed. Eighteen patients (26.87% of total) underwent caval filter positioning, without evidence of complications during its positioning or removal. Life expectancy was particularly low for the cases of RCC without clear cell histotype (7 cases in our series, 10.4% of total) that always was less than one year from surgery.
authors.affiliation: Urology Unit, Ospedale di Circolo e Fondazione Macchi, Varese. gmo.pirola@gmail.com.
authors.forename: Giacomo Maria
authors.initials: GM
authors.lastname: Pirola
authors.forename: Giovanni
authors.initials: G
authors.lastname: Saredi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Damiano
authors.forename: Alberto Mario
authors.initials: AM
authors.lastname: Marconi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D020246:Venous Thrombosis / Q000209:etiology*; D055815:Young Adult