title: Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings.
abstract: OBJECTIVE
  The aim of this study was to calculate the horizontal growth rate of melanoma in vivo and to correlate it with morphologic findings.
  
  
  METHODS
  We searched our database for melanomas for which sequential dermatoscopic images and histopathologic slides were available. The final sample consisted of 50 melanomas of 48 patients (mean age: 50 ± 15 years, 62% females). We calculated the horizontal growth rate in mm(2) per year by morphometric analysis of digital dermatoscopic images. Dermatoscopic and dermatopathologic findings were assessed according to predefined criteria and correlated with the horizontal growth rate.
  
  
  RESULTS
  The median time interval between baseline and follow-up image was 12 months (range: 2-100 months). The majority of melanomas were in situ (n=28, 56%). The mean horizontal growth rate of all melanomas was 5.3 mm(2)/year (SD: ± 5.8 mm(2)/year). The histopathologic findings of numerous and large epidermal nests were associated with rapid growth. This histopathologic pattern corresponded to a pattern of clods ("globules") dermatoscopically. From a dermatoscopic point of view, melanomas with a main pattern of clods grew significantly faster (mean horizontal growth rate: 10.4 mm(2)/year, 95% CI: 6.4-14.4 mm(2)/year) than melanomas with mainly a reticular pattern (4.8 mm(2)/year, 95% CI: 2.7-7.0 mm(2)/year) or with other patterns (2.6 mm(2)/year, 95% CI: -0.5-5.6 mm(2)/ year, p=0.01).
  
  
  CONCLUSIONS
  Morphologic characteristics of melanoma are associated with biologic behavior. Large and numerous epidermal nests (corresponding to a pattern of clods dermatoscopically) indicate more rapid growth.
authors.affiliation: Department of Dermatology, Division of General Dermatology, Medical University of Vienna, Austria.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Beer
authors.affiliation: Department of Dermatology, Division of General Dermatology, Medical University of Vienna, Austria.
authors.forename: Lina
authors.initials: L
authors.lastname: Xu
authors.affiliation: Department of Dermatology, Division of General Dermatology, Medical University of Vienna, Austria.
authors.forename: Philipp
authors.initials: P
authors.lastname: Tschandl
authors.affiliation: Department of Dermatology, Division of General Dermatology, Medical University of Vienna, Austria.
authors.forename: Harald
authors.initials: H
authors.lastname: Kittler
keywords: dermotoscopy; horizontal growth rate; melanoma in vivo