title: Introduction to focus issue: rhythms and dynamic transitions in neurological disease: modeling, computation, and experiment.
abstract: Rhythmic neuronal oscillations across a broad range of frequencies, as well as spatiotemporal phenomena, such as waves and bumps, have been observed in various areas of the brain and proposed as critical to brain function. While there is a long and distinguished history of studying rhythms in nerve cells and neuronal networks in healthy organisms, the association and analysis of rhythms to diseases are more recent developments. Indeed, it is now thought that certain aspects of diseases of the nervous system, such as epilepsy, schizophrenia, Parkinson's, and sleep disorders, are associated with transitions or disruptions of neurological rhythms. This focus issue brings together articles presenting modeling, computational, analytical, and experimental perspectives about rhythms and dynamic transitions between them that are associated to various diseases.
authors.affiliation: Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA.
authors.forename: Tasso J
authors.initials: TJ
authors.lastname: Kaper
authors.affiliation: Department of Mathematics and Statistics, Boston University, Boston, Massachusetts 02215, USA.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Kramer
authors.affiliation: Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, New Jersey 07102, USA.
authors.forename: Horacio G
authors.initials: HG
authors.lastname: Rotstein
mesh_terms: D001683:Biological Clocks; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology*; D012559:Schizophrenia / Q000503:physiopathology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*