title: [Neoadjuvant chemotherapy with capecitabine plus oxaliplatin and bevacizumab for the treatment of patients with resectable metastatic colorectal cancer].
abstract: We analyzed the clinical efficacy and safety of capecitabine plus oxaliplatin( XELOX) and bevacizumab( BV) as neoadjuvant chemotherapy, administered for the treatment of patients with resectable metastatic colorectal cancer between October 2009 and December 2012. Of the 15 patients who received chemotherapy, 9 received XELOX plus BV and 6 patients received XELOX alone. The median number of therapy courses was 4. The overall response rate was 73.3%. All patients underwent R0 resection. The median disease-free survival was 522 days. The median follow-up time was 607 days. No major Grade 3 or 4 adverse events occurred during chemotherapy and no perioperative complications were noted. Our findings suggest that XELOX (plus BV) as neoadjuvant therapy is useful for the prevention of early recurrence and is clinically efficacious and safe for the treatment of colorectal cancer with resectable metastases.
authors.affiliation: Dept. of Gastroenterology, Saiseikai Yokohamashi Tobu Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kemmochi
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Egawa
authors.forename: Koki
authors.initials: K
authors.lastname: Mihara
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Ohkubo
authors.forename: Takayuki
authors.initials: T
authors.lastname: Mori
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagashima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Makino
authors.forename: Wataru
authors.initials: W
authors.lastname: Yamamuro
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000069287:Capecitabine; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D010071:Oxaloacetates
chemical_list: D010071:Oxaloacetates; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil