title: An algebraic view of bacterial genome evolution.
abstract: Rearrangements of bacterial chromosomes can be studied mathematically at several levels, most prominently at a local, or sequence level, as well as at a topological level. The biological changes involved locally are inversions, deletions, and transpositions, while topologically they are knotting and catenation. These two modelling approaches share some surprising algebraic features related to braid groups and Coxeter groups. The structural approach that is at the core of algebra has long found applications in sciences such as physics and analytical chemistry, but only in a small number of ways so far in biology. And yet there are examples where an algebraic viewpoint may capture a deeper structure behind biological phenomena. This article discusses a family of biological problems in bacterial genome evolution for which this may be the case, and raises the prospect that the tools developed by algebraists over the last century might provide insight to this area of evolutionary biology.
authors.affiliation: Centre for Research in Mathematics, School of Computing, Engineering and Mathematics, University of Western Sydney, Sydney, Australia, a.francis@uws.edu.au.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Francis
mesh_terms: D005075:Biological Evolution; D026942:DNA Topoisomerases / Q000378:metabolism; D004269:DNA, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial / Q000235:genetics*; D009154:Mutation / Q000235:genetics*; D045522:Recombinases / Q000378:metabolism
chemical_list: D004269:DNA, Bacterial; D045522:Recombinases; D026942:DNA Topoisomerases