title: Targeting the host hemostatic system function in bacterial infection for antimicrobial therapies.
abstract: The hemostatic system is an important player in host's response to infection. It has been shown that host hemostatic factors as well as platelets, interact with various proteins from bacteria and play important roles in host defense against infections. This review summarizes studies of function of host hemostatic system in host defense against bacterial infections and efforts to target hemostatic system interaction with pathogens to develop potential antimicrobial therapies.
authors.affiliation: Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO, USA.
authors.forename: Yuanxi
authors.initials: Y
authors.lastname: Xu
authors.forename: Haiqing
authors.initials: H
authors.lastname: Yu
authors.forename: Hongmin
authors.initials: H
authors.lastname: Sun
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D006487:Hemostasis / Q000187:drug effects* / Q000502:physiology; D006801:Humans
chemical_list: D000890:Anti-Infective Agents