title: Pharmacotherapy of essential tremor.
abstract: Essential tremor (ET) is a common movement disorder but its pathogenesis remains poorly understood. This has limited the development of effective pharmacotherapy. The current therapeutic armamentaria for ET represent the product of careful clinical observation rather than targeted molecular modeling. Here we review their pharmacokinetics, metabolism, dosing, and adverse effect profiles and propose a treatment algorithm. We also discuss the concept of medically refractory tremor, as therapeutic trials should be limited unless invasive therapy is contraindicated or not desired by patients.
authors.affiliation: Department of Neurology, Vanderbilt University, Nashville, TN.
authors.forename: Peter
authors.initials: P
authors.lastname: Hedera
authors.affiliation: Department of Neurology, Slovak Medical University and University Hospital Bratislava, Slovakia.
authors.forename: František
authors.initials: F
authors.lastname: Cibulčík
authors.affiliation: Department of Neurology, Vanderbilt University, Nashville, TN.
authors.forename: Thomas L
authors.initials: TL
authors.lastname: Davis
keywords: essential tremor; gabapentin; pathogenesis; pregabalin; primidone; propranolol; topiramate