title: Synthesis and characterization of 4-(2-aminoethyl)aniline imprinted polymer as a highly effective sorbent of dopamine.
abstract: The aim of the study was to develop an efficient sorbent for the separation of dopamine. 4-(2-Aminoethyl)aniline was chosen as a pseudo-template to produce the imprinted polymers from seven different functional monomers in the presence of ethylene glycol dimethacrylate as a cross-linker. The binding capacity showed that the highest binding specificity towards dopamine was achieved when methacrylic acid was used as the monomer in methanol solution to form a polymer matrix. The imprinting factor value was equal to 22.96. Other biogenic amines were bound much more weakly. A simple theoretical model was used to give an insight into the imprinting process and the selectivity of polymer matrix. Two artificial urine samples were used as the complex matrices to show the usefulness of the new sorbent for bioanalysis.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
authors.forename: Piotr
authors.initials: P
authors.lastname: Luliński
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Dana
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland. Electronic address: dorota.maciejewska@wum.edu.pl.
authors.forename: Dorota
authors.initials: D
authors.lastname: Maciejewska
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001665:Binding Sites; D004298:Dopamine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D054802:Molecular Imprinting; D011108:Polymers / Q000737:chemistry*; D013818:Thermogravimetry
chemical_list: D000814:Aniline Compounds; D011108:Polymers; D004298:Dopamine
keywords: 4-(2-Aminoethyl)aniline; Binding properties; Dopamine; Molecular modeling; Molecularly imprinted polymers