title: Involvement of IL-23 in enteropathic arthritis patients with inflammatory bowel disease: preliminary results.
abstract: The role of interleukin (IL)-23 in the pathogenesis of inflammatory bowel disease (IBD) remains unclear. The aim of this work was to study the serum level of IL-23 in IBD with and without arthritis and determine its relation to the subsets and clinical features of the disease. Thirty-seven patients with IBD including 11 with arthritis were included in the study with a mean age of 30.86 ± 4.66 years. Twenty healthy subjects served as control. Seronegative spondyloarthropathy was present in 11 (29.73 %) of the IBD patients; Crohn's disease (CD) was present in 23 and 14 had ulcerative colitis (UC). Serum level of IL-23 was measured in all patients and control by ELISA. IL-23 was significantly higher in IBD patients (46.24 ± 27.19 pg/ml) compared to control (24.1 ± 2.31 pg/ml) (p < 0.0001) being higher in CD patients (52.57 ± 32.78 pg/ml) compared to those with UC (35.86 ± 6.41 pg/ml) (p = 0.026). Furthermore, it was significantly higher in those with peripheral and/or axial arthritis (67.73 ± 40.85 pg/ml) compared to patients without (37.15 ± 10.37 pg/ml) (p = 0.03). There was a tendency to a higher level in males (49.15 ± 30.97 pg/ml) compared to females (38.4 ± 9.54 pg/ml). Serum IL-23 is increased in IBD especially those with CD associated with arthritis and sacroiliitis. The IL-23 could be added to the biomarkers of development of arthritis in IBD patients. These results also confirm the findings of previous studies on the critical role played by IL-23 in the pathogenesis of IBD making it an important new therapeutic target for these patients.
authors.affiliation: Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt, gheitamer@hotmail.com.
authors.forename: Tamer A
authors.initials: TA
authors.lastname: Gheita
authors.forename: Iman I
authors.initials: II
authors.lastname: El Gazzar
authors.forename: Hussein S
authors.initials: HS
authors.lastname: El-Fishawy
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Aboul-Ezz
authors.forename: Sanaa A
authors.initials: SA
authors.lastname: Kenawy
mesh_terms: D000328:Adult; D001168:Arthritis / Q000097:blood* / Q000150:complications*; D015415:Biomarkers / Q000097:blood; D003093:Colitis, Ulcerative / Q000097:blood* / Q000150:complications; D003424:Crohn Disease / Q000097:blood* / Q000150:complications; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood / Q000150:complications; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000150:complications*; D053759:Interleukin-23 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D025242:Spondylarthropathies / Q000097:blood / Q000150:complications; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053759:Interleukin-23