title: LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins.
abstract: The LIM-only subclass of LIM proteins is a family of nuclear transcription co-regulators that are characterized by the exclusive presence of two tandem LIM domains and no other functional domains. To date, four LIM-domain-only (LMO) proteins (LMO1-LMO4) have been identified. They regulate gene transcription by functioning as "linker" or "scaffolding" proteins with a remarkable potential to mediate protein-protein interactions. These proteins play important roles in cell fate determination, cell growth and differentiation, tissues patterning, and organ development. In this review, we briefly described the functions of LMO proteins in the organ development and diseases. We also summarized the interaction proteins of each LMO family member, which may contribute to elucidating the functions of these mysterious and important linker proteins.
authors.affiliation: Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050017, Hebei, People's Republic of China.
authors.forename: Meixiang
authors.initials: M
authors.lastname: Sang
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Meijie
authors.initials: M
authors.lastname: Sang
authors.forename: Xinliang
authors.initials: X
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Cuizhi
authors.initials: C
authors.lastname: Geng
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D060588:LIM Domain Proteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D004268:DNA-Binding Proteins; D060588:LIM Domain Proteins; C065072:LMO1 protein, human; C085117:LMO2 protein, human; C502335:LMO3 protein, human; C114905:LMO4 protein, human; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors