title: A review of economic impact of targeted oral anticancer medications.
abstract: There has been a rapid increase in the use of targeted oral anticancer medications (OAMs) in the past decade. As OAMs are often expensive, economic consideration play a significant role in the decision to prescribe, receive or cover them. This paper performs a systematic review of costs or budgetary impact of targeted OAMs to better understand their economic impact on the healthcare system, patients as well as payers. We present our review in a summary table that describes the method and main findings, take into account multiple factors, such as country, analytical approach, cost type, study perspective, timeframe, data sources, study population and care setting when we interpret the results from different papers, and discuss the policy and clinical implications. Our review raises a concern regarding the role of sponsorship on findings of economic analyses as the vast majority of pharmaceutical company-sponsored studies reported cost advantages toward the sponsor's drugs.
authors.affiliation: Departments of Health Services Research and Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Chan
authors.initials: C
authors.lastname: Shen
authors.forename: Chun-Ru
authors.initials: CR
authors.lastname: Chien
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Geynisman
authors.forename: Fabrice
authors.initials: F
authors.lastname: Smieliauskas
authors.forename: Ya-Chen T
authors.initials: YC
authors.lastname: Shih
mesh_terms: D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D003657:Decision Making; D003695:Delivery of Health Care / Q000191:economics; D016503:Drug Delivery Systems; D004345:Drug Industry / Q000191:economics; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000191:economics; D012109:Research Support as Topic / Q000191:economics
chemical_list: D000970:Antineoplastic Agents