title: Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly complicated by the onset of acute myeloid leukemia.
abstract: We herein describe the case of a 62-year-old woman who presented with anemia and an 8-month history of weight loss. Bone marrow aspiration showed increased myeloblasts. The histopathology findings of biopsy specimens of the right cervical lymph node and intestinal mass indicated B-lymphoproliferative disorder (B-LPD) with Hodgkin lymphoma-like morphologic features and polymorphous diffuse large B-cell lymphoma (DLBCL), respectively. In addition, both types of lymphoma cells were positive for Epstein-Barr virus (EBV)-encoded small RNA-1. The patient was diagnosed with EBV-associated B-LPD and simultaneous acute myeloid leukemia (AML). This is the first case of a patient diagnosed with simultaneous EBV-positive DLBCL of the elderly and AML.
authors.affiliation: Department of Hematology and Oncology, Kurashiki Central Hospital, Japan.
authors.forename: Akane
authors.initials: A
authors.lastname: Kunitomi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kotani
authors.forename: Naoya
authors.initials: N
authors.lastname: Ukyo
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ono
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nakamine
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nohgawa
mesh_terms: D000367:Age Factors; D000368:Aged; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000175:diagnosis*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000175:diagnosis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000175:diagnosis*