title: Volume localized spin echo correlation spectroscopy with suppression of 'diagonal' peaks.
abstract: Two dimensional homonuclear (1)H correlation spectroscopy is of considerable interest for volume localized spectral studies, both in vivo and in vitro, of biological as well as material objects. The information principally sought from correlation spectra resides in the cross-peaks, which are often masked however by the presence of diagonal peaks in COSY, or 'pseudo-diagonal' peaks at F1=0 in SECSY. It has therefore been a concern to suppress these diagonal or 'pseudo-diagonal' peaks, in order to ensure that cross-peak information is fully discernible. We present here a report of our work on volume localized DIagonal Suppressed Spin Echo Correlation specTroscopy (LDISSECT) and demonstrate its performance in comparison to the standard volume localized SECSY experiment, employing brain metabolite phantoms in a gel. The sequence works in the inhomogeneous, multi-component environment by exploiting the short acquisition time to suppress undesired information by employing an additional rf pulse. A brief description of the pulse sequence, its theory, and simulations are also included, besides experimental benchmarking on two brain metabolite phantoms in gel phase.
authors.affiliation: MRI-MRS Centre, Department of Chemistry, Indian Institute of Technology-Madras, Chennai 600036, Tamil Nadu, India.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Banerjee
authors.affiliation: MRI-MRS Centre, Department of Chemistry, Indian Institute of Technology-Madras, Chennai 600036, Tamil Nadu, India. Electronic address: chandrakumar.iitm@gmail.com.
authors.forename: N
authors.initials: N
authors.lastname: Chandrakumar
mesh_terms: D000596:Amino Acids / Q000032:analysis; D001923:Brain Chemistry; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D005782:Gels; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging
chemical_list: D000596:Amino Acids; D005782:Gels
keywords: LDISSECT; LSECSY; MRS; Suppression of diagonal or pseudo diagonal peaks; Volume localized correlation spectroscopy; Volume localized spectroscopy