title: Tissue engineering considerations in dental pulp regeneration.
abstract: Regenerative endodontic procedure is introduced as a biologically based treatment for immature teeth with pulp necrosis. Successful clinical and radiographic outcomes following regenerative procedures have been reported in landmark case reports. Retrospective studies have shown that this conservative treatment allows for continued root development and increases success and survival rate of the treated teeth compared to other treatment options. Although the goal of treatment is regeneration of a functional pulp tissue, histological analyses show a different outcome. Developing predictable protocols would require the use of key elements for tissue engineering: stem cells, bioactive scaffolds, and growth factors. In this study we will review the evidence based steps and outcomes of regenerative endodontics.
authors.affiliation: Department of Endodontics, Prosthodontics and Operative Dentistry, School of Dentistry, University of Maryland, Baltimore, MD, USA; ; Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Nosrat
authors.affiliation: Department of Endodontics, Prosthodontics and Operative Dentistry, School of Dentistry, University of Maryland, Baltimore, MD, USA;
authors.forename: Jong
authors.initials: J
authors.lastname: Ryul Kim
authors.affiliation: Department of Endodontics, Prosthodontics and Operative Dentistry, School of Dentistry, University of Maryland, Baltimore, MD, USA;
authors.forename: Prashant
authors.initials: P
authors.lastname: Verma
authors.affiliation: Department of Endodontics, Prosthodontics and Operative Dentistry, School of Dentistry, University of Maryland, Baltimore, MD, USA;
authors.forename: Priya
authors.initials: P
authors.lastname: S Chand
keywords: Growth Factor; Progenitor Cells; Pulp Regeneration; Scaffold; Stem Cell; Tissue Engineering; Transplantation