title: Atopic eczema: a disease modulated by gene and environment.
abstract: Atopic eczema (AE) is a chronic inflammatory skin disease that is mainly characterized by pruritus and epidermal barrier dysfunction. Between 15% and 20% of children and 1%-3% of adults are affected worldwide. AE is a complex disease triggered by multiple triggers, including gene and environmental factors. Impaired skin barrier function, modifications of the immune system, and hyper-reactivity to environmental stimulation directly cause and aggravate AE. In this review, we provide an overview of the recent developments and future directions in the pathogenesis of AE.
authors.affiliation: Department of Dermatology, Shanghai Seventh People's Hospital, Shanghai, China;
authors.forename: Weian
authors.initials: W
authors.lastname: Mao
authors.affiliation: Shanghai University of Traditional Chinese Medicine, Shanghai, China.
authors.forename: Jingyi
authors.initials: J
authors.lastname: Mao
authors.affiliation: Department of Dermatology, Shanghai Seventh People's Hospital, 358 Datong Road, Pudong New Area, Shanghai 200137, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Dermatology, Shanghai Seventh People's Hospital, 358 Datong Road, Pudong New Area, Shanghai 200137, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Dermatology, Shanghai Seventh People's Hospital, 358 Datong Road, Pudong New Area, Shanghai 200137, China.
authors.forename: Dilian
authors.initials: D
authors.lastname: Cao
authors.affiliation: Department of Dermatology, Shanghai Seventh People's Hospital, 358 Datong Road, Pudong New Area, Shanghai 200137, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Qu
mesh_terms: D003876:Dermatitis, Atopic / Q000235:genetics*; D059647:Gene-Environment Interaction; D006801:Humans