title: [Indoleamine 2, 3-dioxygenase activity during neoadjuvant chemotherapy in patients with breast cancer].
abstract: We evaluated the significance of indoleamine 2, 3-dioxygenase (IDO) in breast cancer patients during neoadjuvant chemotherapy. IDO activity can be determined by the tryptophan( Trp)/kynurenine( Kyn) ratio. Trp and Kyn were measured by high performance liquid chromatography (HPLC). The correlations between the Trp/Kyn ratios in the pre-chemotherapy, post-chemotherapy, and post-surgery phases of treatment and the effects of chemotherapy were studied. The Trp/ Kyn ratios were significantly lower in the post-epirubicin and cyclophosphamide( EC) chemotherapy phase and post- weekly paclitaxel( wPac) chemotherapy phase than in the pre-chemotherapy phase and post-chemotherapy phase, respectively. There was no significant correlation between the Trp/Kyn ratio in any phase and the response rate. These results suggest that measurement of the Trp/Kyn ratio is not useful for predicting the rate of response to chemotherapy in patients with breast cancer.
authors.affiliation: Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakurai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujisaki
authors.forename: Saki
authors.initials: S
authors.lastname: Nagashima
authors.forename: Tetsuyo
authors.initials: T
authors.lastname: Maeda
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Tomita
authors.forename: Shuhei
authors.initials: S
authors.lastname: Suzuki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Hirano
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Enomoto
authors.forename: Sadao
authors.initials: S
authors.lastname: Amano
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D007737:Kynurenine / Q000032:analysis; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D014364:Tryptophan / Q000032:analysis
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D007737:Kynurenine; D014364:Tryptophan