title: PER3, a novel target of miR-103, plays a suppressive role in colorectal cancer in vitro.
abstract: Colorectal cancer has become the third most common cancer and leads to high mortality worldwide. Although colorectal cancer has been studied widely, the underlying molecular mechanism remains unclear. PER3 is related to tumor differentiation and the progression of colorectal cancer. High expression of miR-103 is associated with poor prognosis in patients with colorectal cancer. However, the relationship between miR-103 and PER3 in CRC cells remains unclear. In this study, we found that PER3 was downregulated in CRC tissues and CRC cell lines, whereas miR-103 was upregulated in CRC cell lines. We also found that PER3 promoted CRC cells apoptosis. These results indicate that PER3 plays a suppressive role in CRC cells. Moreover, we found that PER3 was targeted, at least partially, by miR-103. Taken together, we provide evidence to characterize the role of PER3 in CRC, which may be a new therapeutic target for CRC.
authors.affiliation: The Nurse Department of Organ Transplantation, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 41008.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Hong
authors.affiliation: Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China, 410013.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 41008.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Sai
authors.affiliation: Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China, 41008.
authors.forename: Su
authors.initials: S
authors.lastname: Tao
mesh_terms: D020413:3' Untranslated Regions; D017209:Apoptosis; D018938:Caco-2 Cells; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology; D015536:Down-Regulation; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D009367:Neoplasm Staging; D056950:Period Circadian Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D020413:3' Untranslated Regions; C544749:MIRN103 microRNA, human; D035683:MicroRNAs; C512644:PER3 protein, human; D056950:Period Circadian Proteins; D016159:Tumor Suppressor Protein p53