title: Chronic myelogenous leukemia after postoperative adjuvant S-1 therapy for rectal cancer: a case report.
abstract: We report a case in which chronic myelogenous leukemia (CML) developed after postoperative adjuvant S-1 therapy for rectal cancer. A 56-year-old man was diagnosed with rectal adenocarcinoma, which was treated with abdominoperineal resection followed by a year of adjuvant S-1 therapy. At 39 postoperative months, he was diagnosed with CML. Although it remains unclear that CML that develops after treatment involving cytotoxic agents is treatment-related, clinicians should be aware of the possibility of CML developing after S-1 therapy.
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Manabe
authors.affiliation: Department of Surgery, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Nishii
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Junya
authors.initials: J
authors.lastname: Okita
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Johji
authors.initials: J
authors.lastname: Nagasaki
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Naonori
authors.initials: N
authors.lastname: Harada
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Aoyama
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Takeo
authors.initials: T
authors.lastname: Kumura
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Ohta
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Furukawa
authors.affiliation: Department of Surgery, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takeuchi
authors.affiliation: Department of Hematology, Seichokai Fuchu Hospital 1-10-17 Hiko-cho, Izumi, Osaka 594-0076, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Mugitani
keywords: Chronic myelogenous leukemia; S-1; fluoropyrimidine; rectal cancer