title: A comparative study of antitumor activities and DNA cleavage on a class of dehydroabietylamine derivatives.
abstract: A series of novel dehydroabietylamine derivatives containing tricyclic diterpene structures were synthesized. The antitumor activities of these compounds against L02, Hey-1B and HepG2 cells were investigated. Significant activity was discovered forfourteen analogs. Meanwhile these compounds exhibit DNA cleavage activities on plasmid DNA (Escherichia coli), which depend on the Schiff base structure and the substituent of the aromatic moiety. Our findings present further information on the relationship between the chemical structure, biological function and DNA cleavage characteristics.
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
authors.forename: Chao-Xiang
authors.initials: CX
authors.lastname: Liu
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
authors.forename: Zhong-Xiang
authors.initials: ZX
authors.lastname: Lin
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Yu
authors.affiliation: College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Department of Chemistry, Cleveland State University, Cleveland, USA.
authors.forename: Ai-Min
authors.initials: AM
authors.lastname: Zhou
authors.affiliation: School of Life Sciences, Northeast Normal University, Changchun, China.
authors.forename: Yong-Li
authors.initials: YL
authors.lastname: Bao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D053837:DNA Cleavage / Q000187:drug effects*; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D007501:Iron / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D007202:Indicators and Reagents; D007501:Iron