title: Trinorditerpenes from the roots of Flueggea virosa.
abstract: Two trinorditerpenes, flueggrenes A and B (1 and 2), have been isolated from the roots of Flueggea virosa. Their structures were established by extensive analyses of spectroscopic data. The isolates were evaluated for anti-HCV activity, as well as the inhibition of superoxide anion generation and elastase release in response to FMLP/cytochalasin B.
authors.affiliation: School of Pharmacy, China Medical University, Taichung 404, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan. Electronic address: chaochihhua@hotmail.com.
authors.forename: Chih-Hua
authors.initials: CH
authors.lastname: Chao
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan.
authors.forename: Ju-Chien
authors.initials: JC
authors.lastname: Cheng
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: De-Yang
authors.initials: DY
authors.lastname: Shen
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. Electronic address: tswu@mail.ncku.edu.tw.
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019665:Euphorbiaceae; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots
chemical_list: D004224:Diterpenes; D010936:Plant Extracts
keywords: Anti-HCV; Flueggea virosa; Flueggrene A; Flueggrene B