title: Analysis of short-term change in subfoveal choroidal thickness in eyes with age-related macular degeneration using optical coherence tomography.
abstract: OBJECTIVE
  To measure the subfoveal choroidal thickness in patients with age-related macular degeneration (AMD) over 6 months.
  
  
  METHODS
  A retrospective, observational study of patients with AMD followed up for 6 months at the New England Eye Center. Baseline and 6-month follow-up subfoveal choroidal thickness was measured using spectral-domain OCT and compared.
  
  
  RESULTS
  For the entire cohort, there was statistically significant thinning of the subfoveal choroidal thickness at 6 months compared to baseline that was driven by the cohort of patients with neovascular AMD (181.2 ± 75 μm to 173.4 ± 63 μm; P = .049).
  
  
  CONCLUSIONS
  There was a statistically significant decrease in subfoveal choroidal thickness observed in this cohort of patients with AMD over 6 months, but it was driven by the subgroup of patients with neovascular age-related macular degeneration.
authors.forename: Jordana G
authors.initials: JG
authors.lastname: Fein
authors.forename: Lauren A
authors.initials: LA
authors.lastname: Branchini
authors.forename: Varsha
authors.initials: V
authors.lastname: Manjunath
authors.forename: Caio V
authors.initials: CV
authors.lastname: Regatieri
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.forename: Jay S
authors.initials: JS
authors.lastname: Duker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D002829:Choroid / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D005584:Fovea Centralis; D057092:Geographic Atrophy / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D057135:Wet Macular Degeneration / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D020533:Angiogenesis Inhibitors