title: New cytotoxic alkylated anthraquinone analogues from a soil actinomycete Streptomyces sp. WS-13394.
abstract: Four new alkylated anthraquinone analogues (1-4) were isolated from a soil actimomycete Streptomyces sp. WS-13394. The structures of compounds 1-4 were elucidated to be 1,4,6-trihydroxy-8-alkylanthraquinones by means of spectroscopic methods, including UV, one dimensional (1D), 2D-NMR and MS spectrometry. All compounds showed activities against BGC-823 and MCF-7 with IC50 from 0.99 to 3.54 µg/mL, while 2 exhibited cytotoxicity against HepG2, A875, BGC-823 and MCF-7 with IC50 2.29, 4.90, 0.99, and 1.66 µg/mL, respectively.
authors.affiliation: Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences.
authors.forename: Zhao-Yuan
authors.initials: ZY
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Fang
authors.forename: Li-Qiao
authors.initials: LQ
authors.lastname: Shi
authors.forename: Zhong-Yi
authors.initials: ZY
authors.lastname: Wan
authors.forename: Yong
authors.initials: Y
authors.lastname: Min
authors.forename: Kai-Mei
authors.initials: KM
authors.lastname: Wang
mesh_terms: D039903:Actinobacteria / Q000737:chemistry*; D000478:Alkylation; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D012987:Soil / Q000737:chemistry*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D012987:Soil