title: Heritability of DUI convictions: a twin study of driving under the influence of alcohol.
abstract: BACKGROUND
  The study was undertaken to assess the relative contributions of genetic and environmental influences on drunk-driving.
  
  
  METHODS
  Driving records of a cohort of male and female twins (N = 17,360) from the Mid-Atlantic Twin Registry were examined. Structural equation models were used to estimate the magnitude of genetic and environmental effects on male and female phenotypes, and test for gender differences.
  
  
  RESULTS
  There were significant gender and age effects. Compared with females, males were five times more likely to engage in driving under the influence. Among persons aged 21-49 years, the risk for drunk-driving was eight times that for those aged 50+ years and five times greater than those ≤20 years. In both males and females, aged 21-49 years, a large proportion (57%) of the variance in drunk-driving was due to genetic factors and the remaining 43% due to individual specific environmental influences.
  
  
  CONCLUSIONS
  Drunk-driving is under significant genetic influence in both males and females. Our findings suggest that a different set of genes influence DUIs in men and women.
authors.affiliation: Wellpoint Inc., 120 Monument Circle, Indianapolis, IN, USA.
authors.forename: Emmanuel A
authors.initials: EA
authors.lastname: Anum
authors.affiliation: Department of Human and Molecular Genetics, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Judy
authors.initials: J
authors.lastname: Silberg
authors.affiliation: Department of Internal Medicine, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Sheldon M
authors.initials: SM
authors.lastname: Retchin
mesh_terms: D000328:Adult; D001334:Automobile Driving / Q000523:psychology*; D004327:Drinking Behavior; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D014429:Twins, Dizygotic / Q000235:genetics* / Q000523:psychology; D014430:Twins, Monozygotic / Q000235:genetics* / Q000523:psychology