title: Reducing survey burden: feasibility and validity of PROMIS measures in multiple sclerosis.
abstract: Patient-reported outcomes are important for clinical research and care, yet administering and scoring the questionnaires requires considerable effort and time. The Patient Reported Outcomes Measurement Information System (PROMIS) could considerably reduce administrative obstacles and lessen survey burden for participants.
  
  
  
  Assess the feasibility and validity of PROMIS, compared to commonly-used legacy measures for multiple sclerosis (MS).
  
  
  
  In this cross-sectional survey, 133 participants with confirmed MS completed legacy surveys and PROMIS Computerized Adaptive Tests (CATs) for depression, anxiety, pain, fatigue and physical function. We conducted a multi-trait, multi-method analysis and verified results with confirmatory factor analysis.
  
  
  
  The correlations between PROMIS and the corresponding legacy measures were large (0.67 to 0.87). The multi-trait, multi-method criteria were generally well met, providing good evidence of the validity of PROMIS measures. PROMIS surveys asked fewer questions and required substantially less time to complete than the legacy scales.
  
  
  
  Our results provide evidence of the construct validity of PROMIS for use with MS patients. Several aspects of the PROMIS CATs made them an important resource, including: (a) less time was required to complete them; (b) missing data was reduced; and (c) the automatic scoring referenced the general population. Our findings support the use of PROMIS in MS research and may have broader implications for clinical care, as well.
authors.affiliation: Department of Neurology, Oregon Health and Science University, Portland, OR, USA Helfgott Research Institute, National College of Natural Medicine, Portland, OR, USA senders@ohsu.edu.
authors.forename: Angela
authors.initials: A
authors.lastname: Senders
authors.affiliation: Helfgott Research Institute, National College of Natural Medicine, Portland, OR, USA.
authors.forename: Douglas
authors.initials: D
authors.lastname: Hanes
authors.affiliation: Department of Neurology, Oregon Health and Science University, Portland, OR, USA Department of Neurology, Portland Veterans Affairs Medical Center, OR, USA.
authors.forename: Dennis
authors.initials: D
authors.lastname: Bourdette
authors.affiliation: Department of Neurology, Oregon Health and Science University, Portland, OR, USA Department of Neurology, Portland Veterans Affairs Medical Center, OR, USA.
authors.forename: Ruth
authors.initials: R
authors.lastname: Whitham
authors.affiliation: Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
authors.forename: Lynne
authors.initials: L
authors.lastname: Shinto
mesh_terms: D000328:Adult; D000368:Aged; D001007:Anxiety / Q000175:diagnosis / Q000523:psychology; D003430:Cross-Sectional Studies; D003863:Depression / Q000175:diagnosis / Q000523:psychology; D005240:Feasibility Studies; D005260:Female; D019538:Health Care Surveys; D006304:Health Status; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D010146:Pain / Q000175:diagnosis / Q000523:psychology; D010147:Pain Measurement; D000071066:Patient Reported Outcome Measures; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013997:Time Factors; D057188:Workflow
keywords: Computerized Adaptive Test; PROMIS; multiple sclerosis; outcome measurement; self-reporting; survey design; validation