title: German psoriasis registry PsoBest: objectives, methodology and baseline data.
abstract: BACKGROUND
  The German psoriasis registry PsoBest records the long-term efficacy, safety, patient benefit and treatment regimens of psoriasis.
  
  
  METHODS
  Patients with moderate or severe psoriasis are included in PsoBest when treatment with a conventional systemic agent or biologic is started for the first time. Observation time is five years. Standardized physician and patient case report forms are obtained every three to six months. Baseline data of patients included by 31 December 2012 are presented and compared to the national health care study PsoHealth 2007 (n = 2,009).
  
  
  RESULTS
  602 dermatology practices and clinics have been registered and 199 have recruited n = 2,556 patients (63 % by practices, 37 % by clinics). Initially, n = 808 received biologics (316 adalimumab, 34 efalizumab, 209 etanercept, 75 infliximab, 22 golimumab, 152 ustekinumab) and n = 1,651 conventional systemic therapy (928 fumaric acid esters, 518 methotrexate, 161 cyclosporine A, 191 other drugs or UV treatment). Compared to PsoHealth, patients in PsoBest had on average a higher disease severity (PASI 14.7 vs. 10.1; DLQI 11.0 vs. 7.5; EQ-5D VAS 54.0 vs. 64.5), shorter disease duration (18.2 vs. 21.3 yrs.), lower age (47.3 vs. 51.5), higher rates of psoriatic arthritis (20.5 vs. 19.1 %) and nail psoriasis (55.0 vs. 35.6 %). On average patients receiving biologics were younger, more often male and had higher disease severity and comorbidity.
  
  
  CONCLUSIONS
  Patients in PsoBest represent patients with a high burden of disease.
authors.affiliation: IVDP - Institute for Health Services Research in Dermatology and Nursing, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Augustin
authors.forename: Christina
authors.initials: C
authors.lastname: Spehr
authors.forename: Marc A
authors.initials: MA
authors.lastname: Radtke
authors.forename: Wolf-Henning
authors.initials: WH
authors.lastname: Boehncke
authors.forename: Thomas
authors.initials: T
authors.lastname: Luger
authors.forename: Ulrich
authors.initials: U
authors.lastname: Mrowietz
authors.forename: Michael
authors.initials: M
authors.lastname: Reusch
authors.forename: Klaus
authors.initials: K
authors.lastname: Strömer
authors.forename: Gottfried
authors.initials: G
authors.lastname: Wozel
authors.forename: Ralph
authors.initials: R
authors.lastname: von Kiedrowski
authors.forename: Stephan J
authors.initials: SJ
authors.lastname: Rustenbach
authors.forename: Sandra
authors.initials: S
authors.lastname: Purwins
authors.forename: Kristian
authors.initials: K
authors.lastname: Reich
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001688:Biological Products / Q000627:therapeutic use; D003880:Dermatology / Q000706:statistics & numerical data; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D015995:Prevalence; D011565:Psoriasis / Q000453:epidemiology* / Q000628:therapy*; D012042:Registries; D012307:Risk Factors; D017678:Sex Distribution; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products