title: Cyclic dipeptides from lactic acid bacteria inhibit the proliferation of pathogenic fungi.
abstract: Lactobacillus plantarum LBP-K10 was identified to be the most potent antifungal strain from Korean traditional fermented vegetables. The culture filtrate of this strain showed remarkable antifungal activity against Ganoderma boninense. Five fractions from the culture filtrate were observed to have an inhibitory effect against G. boninense. Also, the electron ionization and chemical ionization indicated that these compounds might be cyclic dipeptides. Of the five active fractions, two fractions showed the most significant anti-Ganoderma activity, and one of these fractions inhibited the growth of Candida albicans. These compounds were identified to be cis-cyclo(L-Val-L-Pro) and cis-cyclo(L-Phe-L-Pro), as confirmed by X-ray crystallography.
authors.affiliation: Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University, Seoul, 151-747, Republic of Korea.
authors.forename: Min-Kyu
authors.initials: MK
authors.lastname: Kwak
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Min-Kyu
authors.initials: MK
authors.lastname: Kim
authors.forename: Dohyun
authors.initials: D
authors.lastname: Moon
authors.forename: Andrew Hyoungjin
authors.initials: AH
authors.lastname: Kim
authors.forename: Sung-Hyun
authors.initials: SH
authors.lastname: Song
authors.forename: Sa-Ouk
authors.initials: SO
authors.lastname: Kang
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D018360:Crystallography, X-Ray; D004151:Dipeptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D032902:Ganoderma / Q000187:drug effects* / Q000254:growth & development; D048191:Lactiplantibacillus plantarum / Q000737:chemistry / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004151:Dipeptides; D010456:Peptides, Cyclic