title: [Swimming training enhances muscle growth and potentiates p70s6k, rpS6 protein expression in rat skeletal muscle].
abstract: OBJECTIVE
  To illustrate the molecular mechanism of skeletal muscle growth by examining the effect of swimming training on skeletal muscle growth and p70s6k, rpS6 protein expression.
  
  
  METHODS
  Twenty four male SD rats were used to establish swimming training models with a 15% body mass load. The training protocol adopted interval swimming training (every other day with 8 weeks). The gastrocnemius and soleus muscle were collected and weighed after training, and the protein expression of p70s6k, rpS6 and their phosphorylated forms were examined.
  
  
  RESULTS
  After 8 weeks treatment, no significant change was observed in skeletal muscle mass between training group (T) and control group (C) (P > 0.05), but muscle mass in training rapamycin (TR) group has a significantly decrease compared with that in T and C groups (P < 0.05). Soleus and gastrocnemius muscle mass index in T group increased significantly compared with C group (P < 0.05). Compared with the C group, the ratio of P-p70s6k/p70s6k in T group increased with significant difference (P < 0.05), but the ratio in TR group was significantly reduced (P < 0.05). The ratio of P-rpS6/rpS6 had a significant difference between TR and T group (P < 0.05).
  
  
  CONCLUSIONS
  These results suggest that the interval training protocol is helpful to increase the relative muscle hypertrophy, and has a role in promoting the expression of p70s6k and rpS6.
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China. rfshi@sus.edu.cn
authors.forename: Reng-Fei
authors.initials: RF
authors.lastname: Shi
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
authors.forename: Shun-Li
authors.initials: SL
authors.lastname: Wang
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
authors.forename: An-Kui
authors.initials: AK
authors.lastname: Wei
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
authors.forename: Hai-Ping
authors.initials: HP
authors.lastname: Yuan
authors.affiliation: School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
mesh_terms: D000818:Animals; D008297:Male; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism* / Q000502:physiology; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D038762:Ribosomal Protein S6 Kinases, 70-kDa / Q000378:metabolism*; D013550:Swimming
chemical_list: D038762:Ribosomal Protein S6 Kinases, 70-kDa