title: Sex difference in the effects of alcohol on gastric emptying in healthy volunteers: a study using the (13)C breath test.
abstract: Several studies on alcohol and gastric emptying using the (13)C breath test showed that alcohol consumption delayed gastric emptying of meals in healthy male subjects. However, they did not employ female subjects, and the retention time of alcoholic beverages in the stomach has not been examined, yet. We examined the retention time (= gastric emptying rate) of alcoholic beverages in the stomach in healthy male and female subjects. We also examined whether the congeners (nonalcoholic components) of red wine have any effect on gastric emptying. The retention time of 60 mL of red wine, vodka, congeners of red wine, or mineral water, was measured using a (13)C labeled acetic acid breath test. In male subjects, the retention time of wine and vodka was significantly longer than that of congeners and mineral water. In female subjects, although the (13)C content in the breath was slightly but significantly decreased by wine and congeners, but not by vodka, and the parameters for gastric emptying did not differ significantly among the 4 drinks. That is, alcohol hardly influenced the retention time in female subjects. In conclusion, there are sex differences in the gastric emptying rate of alcohol.
authors.affiliation: Department of Physiology, Tokyo Kasei University Graduate School of Human Life, Tokyo 173-8602, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Horikoshi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Funakoshi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Miyasaka
authors.forename: Ayako
authors.initials: A
authors.lastname: Sekime
mesh_terms: D001944:Breath Tests; D002247:Carbon Isotopes; D018592:Cross-Over Studies; D000431:Ethanol / Q000378:metabolism / Q000493:pharmacokinetics*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D008297:Male; D008900:Mineral Waters / Q000008:administration & dosage*; D012737:Sex Factors; D013270:Stomach / Q000502:physiology*; D014920:Wine / Q000032:analysis; D055815:Young Adult
chemical_list: D002247:Carbon Isotopes; D008900:Mineral Waters; D000431:Ethanol