title: Esthesioneuroblastoma in children and adolescent: experience on 11 cases with literature review.
abstract: Esthesioneuroblastoma is a rare tumor of the olfactory epithelium. This report analyzed 11 children and adolescents treated in a single institution between 1982 and 2002. For 9 patients, therapy consisted of an initial course of chemotherapy before surgical resection and postoperative radiotherapy, for 1 patient an initial course of chemotherapy before radiotherapy and for another resection before radiotherapy with no chemotherapy. Response to chemotherapy was assessed in 9 patients of whom 6 achieved a complete or a partial remission. Ten patients are long-term survivors. The 5-year actuarial disease-free survival and overall survival rate was 91% (95% confidence interval, 62%-98%). Our study indicates that esthesioneuroblastoma is sensitive to chemotherapy and supports the role of combined modalities including neoadjuvant chemotherapy, surgery, and radiation therapy.
authors.affiliation: Departments of *Pediatric and Adolescent Oncology ‡Radiation Oncology, Institut Gustave Roussy, Villejuif, France †Unit of Pediatric Hematology and Oncology, Children Hospital of Rabat, University of Mohammed V-Souissi, Rabat, Morocco.
authors.forename: Maria
authors.initials: M
authors.lastname: El Kababri
authors.forename: Jean L
authors.initials: JL
authors.lastname: Habrand
authors.forename: Dominique
authors.initials: D
authors.lastname: Valteau-Couanet
authors.forename: Nathalie
authors.initials: N
authors.lastname: Gaspar
authors.forename: Christelle
authors.initials: C
authors.lastname: Dufour
authors.forename: Odile
authors.initials: O
authors.lastname: Oberlin
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D018304:Esthesioneuroblastoma, Olfactory / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D008297:Male; D009296:Nasal Cavity / Q000473:pathology*; D009669:Nose Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome