title: FXYD6 is a new biomarker of cholangiocarcinoma.
abstract: Members of the FXYD domain-containing ion transport regulator protein family, including FXYD3 and FXYD5, play an important role in the pathogenesis of numerous tumors. However, the correlation between the expression of FXYD6 and tumors remains poorly understood. In the current study, the expression of FXYD6 was examined immunohistochemically in 72 cholangiocarcinoma tissues and 30 distal normal bile duct tissues matched with the tumors. The results show that the positive expression rate of FXYD6 was significantly higher in cholangiocarcinoma than that in normal bile duct tissue (69 vs. 33.3%; P=0.002). Furthermore, the positive expression rate of FXYD6 in well- and moderately-differentiated cholangiocarcinoma was clearly higher than that in poorly-differentiated and mucinous cholangiocarcinoma (85.7 vs. 40%; P=0.000). However, there was no significant correlation between the expression of FXYD6 and gender (P=0.393), age (P=0.174), histological type (P=0.123), T stage (P=0.164), lymph node metastasis (P=0.343), perineural invasion (P=0.088) and tumor location (P=0.238). The results of this study indicate that FXYD6 may be a new biomarker for cholangiocarcinoma and may be associated with a favorable prognosis in this malignant disease.
authors.affiliation: Medical College of Soochow University, Industrial Park, Suzhou, Jiangsu 215123, P.R. China.
authors.forename: Xiongfei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Pathology, General Hospital of PLA Second Artillery, Beijing 100888, P.R. China.
authors.forename: Mingzhu
authors.initials: M
authors.lastname: Sun
authors.affiliation: Institute of Geriatrics, PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Yazhuo
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Institute of Geriatrics, PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Honghong
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Pathology, PLA General Hospital, Beijing 100853, P.R. China.
authors.forename: Zhanbo
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Institute of Hepatobiliary Gastrointestinal Disease, General Hospital of PLA Second Artillery, Beijing 100088, P.R. China.
authors.forename: Ningxin
authors.initials: N
authors.lastname: Zhou
authors.affiliation: Key Laboratory of Protein and Peptide Pharmaceuticals, CAS-University of Tokyo Joint Laboratory of Structural Virology and Immunology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, P.R. China.
authors.forename: Xinyun
authors.initials: X
authors.lastname: Yan
keywords: FXYD6; cholangiocarcinoma; differentiation; immunohistochemistry