title: EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium.
authors.affiliation: Faculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Matsuzawa
authors.affiliation: Faculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan. Electronic address: tkawa@yamanashi.ac.jp.
authors.forename: Tatsuyoshi
authors.initials: T
authors.lastname: Kawamura
authors.affiliation: Faculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Youichi
authors.initials: Y
authors.lastname: Ogawa
authors.affiliation: Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Kenji
authors.initials: K
authors.lastname: Maeda
authors.affiliation: Department of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Nakata
authors.affiliation: Faculty of Medicine, Department of Microbiology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Kohji
authors.initials: K
authors.lastname: Moriishi
authors.affiliation: Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Koyanagi
authors.affiliation: AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Gatanaga
authors.affiliation: Faculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Shimada
authors.affiliation: Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA; Department of Infectious Diseases and Hematology, Kumamoto University School of Medicine, Kumamoto, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mitsuya
mesh_terms: D000287:Administration, Topical; D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects; D018920:Coculture Techniques; D003979:Diazonium Compounds / Q000008:administration & dosage / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects* / Q000378:metabolism; D005204:Farnesol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D015658:HIV Infections / Q000517:prevention & control*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007801:Langerhans Cells / Q000166:cytology / Q000187:drug effects* / Q000821:virology; D051379:Mice; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000378:metabolism
chemical_list: D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D003979:Diazonium Compounds; D018894:Reverse Transcriptase Inhibitors; C040772:epoxyfarnesyl diazoacetate; D005204:Farnesol