title: Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling.
abstract: The development of B cells is dependent on the sequential DNA rearrangement of immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a crucial checkpoint that ensures expression of a signalling-competent immunoglobulin heavy chain before commitment to rearrangement and expression of an immunoglobulin light chain. The checkpoint segregates proliferation of pre-B cells from immunoglobulin light chain recombination and their differentiation into B cells. Recent advances have revealed the molecular circuitry that controls two rival signalling systems, namely the interleukin-7 (IL-7) receptor and the pre-B cell receptor, to ensure that proliferation and immunoglobulin recombination are mutually exclusive, thereby maintaining genomic integrity during B cell development.
authors.affiliation: Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA.
authors.forename: Marcus R
authors.initials: MR
authors.lastname: Clark
authors.affiliation: Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA.
authors.forename: Malay
authors.initials: M
authors.lastname: Mandal
authors.affiliation: Department of Biochemistry, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ochiai
authors.affiliation: 1] Department of Discovery Immunology, Genentech Inc. [2] Division of Immunobiology and the Center for Systems Immunology, Cincinnati Children's Hospital Medical Center, Ohio 45229-3039, USA.
authors.forename: Harinder
authors.initials: H
authors.lastname: Singh
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D001853:Bone Marrow / Q000502:physiology; D056742:Cyclin D2 / Q000502:physiology; D056743:Cyclin D3 / Q000502:physiology; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D038041:Lymphopoiesis; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D054420:Pre-B Cell Receptors / Q000502:physiology*; D020395:Receptors, Interleukin-7 / Q000502:physiology*; D050799:STAT5 Transcription Factor / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D056742:Cyclin D2; D056743:Cyclin D3; D007143:Immunoglobulin Heavy Chains; D054420:Pre-B Cell Receptors; D020395:Receptors, Interleukin-7; D050799:STAT5 Transcription Factor; D019869:Phosphatidylinositol 3-Kinases