title: Use of dietary saturated fatty acids and vitamin E in the treatment of alcoholic liver disease.
abstract: Several lines of evidence indicate that dietary fat has the potential to affect the severity of alcohol-induced liver injury. Aside from altering the threshold for alcoholic liver injury, saturated fats can be used to treat experimental alcoholic liver disease. Diets enriched in saturated fatty acids (palm oil and medium chain triglycerides) inhibit cytochrome P450 2E1 and lipid peroxidation and ameliorate established alcoholic liver disease. Vitamin E may also play a role in modulating lipid peroxidation and liver injury. Additionally, plasma levels of endotoxin and liver mRNAs for pro-inflammatory cytokines are also downregulated after treatment with saturated fatty acids. Thus saturated fatty acids are a potential therapeutic intervention in inflammatory liver injury.
authors.affiliation: Dept of Pathology, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: A A
authors.initials: AA
authors.lastname: Nanji