title: Nanocarriers for vascular delivery of anti-inflammatory agents.
abstract: There is a need for improved treatment of acute vascular inflammation in conditions such as ischemia-reperfusion injury, acute lung injury, sepsis, and stroke. The vascular endothelium represents an important therapeutic target in these conditions. Furthermore, some anti-inflammatory agents (AIAs) (e.g., biotherapeutics) require precise delivery into subcellular compartments. In theory, optimized delivery to the desired site of action may improve the effects and enable new mechanisms of action of these AIAs. Diverse nanocarriers (NCs) and strategies for targeting them to endothelial cells have been designed and explored for this purpose. Studies in animal models suggest that delivery of AIAs using NCs may provide potent and specific molecular interventions in inflammatory pathways. However, the industrial development and clinical translation of complex NC-AIA formulations are challenging. Rigorous analysis of therapeutic/side effect and benefit/cost ratios is necessary to identify and optimize the approaches that may find clinical utility in the management of acute inflammation.
authors.affiliation: Department of Pharmacology and Center for Targeted Therapeutics and Translational Nanomedicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email: muzykant@mail.med.upenn.edu.
authors.forename: Melissa D
authors.initials: MD
authors.lastname: Howard
authors.forename: Elizabeth D
authors.initials: ED
authors.lastname: Hood
authors.forename: Blaine
authors.initials: B
authors.lastname: Zern
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Shuvaev
authors.forename: Tilo
authors.initials: T
authors.lastname: Grosser
authors.forename: Vladimir R
authors.initials: VR
authors.lastname: Muzykantov
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D016503:Drug Delivery Systems / Q000379:methods*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D049329:Nanostructures / Q000737:chemistry*; D014652:Vascular Diseases / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents