title: Long-term follow up of endoscopic resection for type 3 gastric NET.
abstract: OBJECTIVE
  To clarify the short and long-term results and to prove the usefulness of endoscopic resection in type 3 gastric neuroendocrine tumors (NETs).
  
  
  METHODS
  Of the 119 type 3 gastric NETs diagnosed from January 1996 to September 2011, 50 patients treated with endoscopic resection were enrolled in this study. For endoscopic resection, endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) was used. Therapeutic efficacy, complications, and follow-up results were evaluated retrospectively.
  
  
  RESULTS
  EMR was performed in 41 cases and ESD in 9 cases. Pathologically complete resection was performed in 40 cases (80.0%) and incomplete resection specimens were observed in 10 cases (7 vs 3 patients in the EMR vs ESD group, P = 0.249). Upon analysis of the incomplete resection group, lateral or vertical margin invasion was found in six cases (14.6%) in the EMR group and in one case in the ESD group (11.1%). Lymphovascular invasions were observed in two cases (22.2%) in the ESD group and in one case (2.4%) in the EMR group (P = 0.080). During the follow-up period (43.73; 13-60 mo), there was no evidence of tumor recurrence in either the pathologically complete resection group or the incomplete resection group. No recurrence was reported during follow-up. In addition, no mortality was reported in either the complete resection group or the incomplete resection group for the duration of the follow-up period.
  
  
  CONCLUSIONS
  Less than 2 cm sized confined submucosal layer type 3 gastric NET with no evidence of lymphovascular invasion, endoscopic treatment could be considered at initial treatment.
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Yong Hwan
authors.initials: YH
authors.lastname: Kwon
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Seong Woo
authors.initials: SW
authors.lastname: Jeon
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Gwang Ha
authors.initials: GH
authors.lastname: Kim
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Jin Il
authors.initials: JI
authors.lastname: Kim
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Il-Kwun
authors.initials: IK
authors.lastname: Chung
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Sam Ryong
authors.initials: SR
authors.lastname: Jee
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Heung Up
authors.initials: HU
authors.lastname: Kim
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Geom Seog
authors.initials: GS
authors.lastname: Seo
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Gwang Ho
authors.initials: GH
authors.lastname: Baik
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Kee Don
authors.initials: KD
authors.lastname: Choi
authors.affiliation: Yong Hwan Kwon, Seong Woo Jeon, Department of Internal Medicine, Kyungpook National University Hospital, Daegu 702-210, South Korea.
authors.forename: Jeong Seop
authors.initials: JS
authors.lastname: Moon
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002276:Carcinoid Tumor / Q000145:classification / Q000473:pathology / Q000601:surgery*; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D018579:Patient Selection; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000145:classification / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D047368:Tumor Burden
keywords: Carcinoid; Endoscopic resection; Neuroendocrine tumor; Stomach; Treatment