title: Is statin-induced diabetes clinically relevant? A comprehensive review of the literature.
abstract: In those predisposed to the development of diabetes (the insulin resistant, obese and older patients) statins may increase the risk of developing diabetes. Despite the fact that the conversion to diabetes is generated from post hoc analyses, it seems to be a class effect with a dose-response relationship. However, statins have not been clearly shown to increase diabetic microvascular complications (retinopathy, nephropathy and neuropathy). Thus, the clinical significance of increased glucose levels in patients treated on statins is uncertain. While the exact mechanism for how statins increase the risk of diabetes is unknown, a possible explanation is through a reduction in adiponectin levels. Despite the fact that higher statin doses are more likely to lead to new-onset diabetes, for every case of diabetes caused, there are approximately three cardiovascular events reduced with high dose versus moderate dose statin therapy. Overall, the small risk of developing type 2 diabetes with statin therapy is far outweighed by the potential of statins to decrease cardiac events.
authors.affiliation: Southside Endocrinology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: D S H
authors.initials: DS
authors.lastname: Bell
authors.forename: J J
authors.initials: JJ
authors.lastname: DiNicolantonio
authors.forename: J H
authors.initials: JH
authors.lastname: O'Keefe
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced* / Q000150:complications / Q000453:epidemiology; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D019317:Evidence-Based Medicine; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D011236:Prediabetic State / Q000150:complications; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: diabetes mellitus; drug mechanism; drug utilization