title: Midtreatment evaluation of lymphoma response to chemotherapy by volume perfusion computed tomography.
abstract: OBJECTIVE
  The aim of this study was to search for chemotherapy-induced perfusion changes of diffuse large B-cell lymphoma, follicular lymphoma, and Hodgkin lymphoma at midtreatment versus baseline volume perfusion computed tomography (VPCT).
  
  
  METHODS
  Forty-five consecutive patients with untreated diffuse large B-cell lymphoma, follicular lymphoma, and Hodgkin lymphoma received VPCT examinations of the tumor bulk at baseline and during chemotherapy (midtreatment). Blood flow (BF), blood volume (BV), and transit constant (K-trans) were determined. Treatment response was categorized according to the Cheson criteria into complete or partial remission and stable or relapsed/progressive disease.
  
  
  RESULTS
  Midtreatment follow-up showed a reduction in BF, BV, and K-trans in all lymphoma subtypes compared with baseline. The reduction in BV was less pronounced in larger tumors. Notably, BF, BV, and K-trans decreased in the responders (complete remission/partial remission) when compared with the nonresponders (stable or relapsed/progressive disease). Less than 10% reduction in BF was shown to be the best VPCT criterion for the identification of nonresponse.
  
  
  CONCLUSIONS
  Chemotherapy-induced perfusion changes in responders are recognizable at midtreatment VPCT.
authors.affiliation: From the *Department of Diagnostic and Interventional Radiology, and †Department of Oncology and Hematology, Eberhard-Karls-University, Tübingen, Germany; and ‡Finance Department, HEC Paris, Jouy en Josas, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Spira
authors.forename: Leonard
authors.initials: L
authors.lastname: Grünwald
authors.forename: Wichard
authors.initials: W
authors.lastname: Vogel
authors.forename: Alexander
authors.initials: A
authors.lastname: Sauter
authors.forename: Sven Michael
authors.initials: SM
authors.lastname: Spira
authors.forename: Claus Detlef
authors.initials: CD
authors.lastname: Claussen
authors.forename: Marius
authors.initials: M
authors.lastname: Horger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D001810:Blood Volume; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D003287:Contrast Media; D005260:Female; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide