title: A Dynamic Dosimetry System for Prostate Brachytherapy.
abstract: The lack of dynamic dosimetry tools for permanent prostate brachytherapy causes otherwise avoidable problems in prostate cancer patient care. The goal of this work is to satisfy this need in a readily adoptable manner. Using the ubiquitous ultrasound scanner and mobile non-isocentric C-arm, we show that dynamic dosimetry is now possible with only the addition of an arbitrarily configured marker-based fiducial. Not only is the system easily configured from accessible hardware, but it is also simple and convenient, requiring little training from technicians. Furthermore, the proposed system is built upon robust algorithms of seed segmentation, fiducial detection, seed reconstruction, and image registration. All individual steps of the pipeline have been thoroughly tested, and the system as a whole has been validated on a study of 25 patients. The system has shown excellent results of accurately computing dose, and does so with minimal manual intervention, therefore showing promise for widespread adoption of dynamic dosimetry.
authors.affiliation: Dept. of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Nathanael
authors.initials: N
authors.lastname: Kuo
authors.affiliation: Philips Research North America, Briarcliff Manor, NY, USA.
authors.forename: Ehsan
authors.initials: E
authors.lastname: Dehghan
authors.affiliation: Dept. of Computer Science, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Anton
authors.initials: A
authors.lastname: Deguet
authors.affiliation: Dept. of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Danny Y
authors.initials: DY
authors.lastname: Song
authors.affiliation: Dept. of Electrical and Computer Engineering, Johns Hopkins University, MD, USA.
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Prince
authors.affiliation: Dept. of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, USA ; Dept. of Electrical and Computer Engineering, Johns Hopkins University, MD, USA.
authors.forename: Junghoon
authors.initials: J
authors.lastname: Lee
keywords: dynamic dosimetry; mobile non-isocentric C-arm; prostate brachytherapy; transrectal ultrasound