title: Association of IL-8 (-251 a/t) gene polymorphism with clinical parameters and chronic periodontitis.
abstract: OBJECTIVE
  To investigate the correlation between IL-8 (-251 A/T) gene polymorphism and susceptibility to chronic periodontitis as well as different clinical parameters and severity of the condition in patients referred to dental school, Shiraz University of Medical Sciences, Shiraz, Iran.
  
  
  METHODS
  In this randomized cross sectional study, 227 non-smoking patients with chronic periodontitis (test) and 40 healthy individuals (control) were enrolled in this experiment and the following clinical parameters were employed in the study: Periodontal Pocket Depth (PPD), Clinical Attachment Level (CAL) and Bone Loss (BL). All participants underwent the PCR (Polymerase Chain Reaction) test to detect 251 A/T Single Nucleotide Polymorphism of IL8 gene.
  
  
  RESULTS
  No significant correlation was perceived between different genotypes of IL-8 and the severity of the periodontal condition (P= 0.164), neither did we detect any substantial association between different IL-8 genotypes and the mean PPD (P=0.525), CAL (P=0.151), BL (P=0.255), PI (P=0.087), BOP (P=0.265) and the average number of teeth (P=0.931).
  
  
  CONCLUSIONS
  The results implied that there was no explicit correlation between 251 (A/T) IL-8 gene polymorphism and the severity of the chronic periodontal disease or to the susceptibility to it.
authors.affiliation: Assistant Professor, Department of Periodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Hengameh
authors.initials: H
authors.lastname: Khosropanah
authors.affiliation: Professor, Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Eskandar Kamali
authors.initials: EK
authors.lastname: Sarvestani
authors.affiliation: Assistant Professor, Department of Periodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Ashkan
authors.initials: A
authors.lastname: Mahmoodi
authors.affiliation: Resident of Periodontology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Golshah
keywords: Chronic Periodontitis; Genetic polymorphism; Interleukin-8