title: Cortical spreading depression in traumatic brain injuries: is there a role for astrocytes?
abstract: Cortical spreading depression (CSD) is a presumably pathophysiological phenomenon that interrupts local cortical function for periods of minutes to hours. This phenomenon is important due to its association with different neurological disorders such as migraine, malignant stroke and traumatic brain injury (TBI). Glial cells, especially astrocytes, play an important role in the regulation of CSD and in the protection of neurons under brain trauma. The correlation of TBI with CSD and the astrocytic function under these conditions remain unclear. This review discusses the possible link of TBI and CSD and its implication for neuronal survival. Additionally, we highlight the importance of astrocytic function for brain protection, and suggest possible therapeutic strategies targeting astrocytes to improve the outcome following TBI-associated CSD.
authors.affiliation: Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
authors.forename: Daniel
authors.initials: D
authors.lastname: Torrente
authors.affiliation: Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Cabezas
authors.affiliation: Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
authors.forename: Marco Fidel
authors.initials: MF
authors.lastname: Avila
authors.affiliation: Instituto Cajal, CSIC, Avenida Doctor Arce 37, 28002 Madrid, Spain.
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: García-Segura
authors.affiliation: Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
authors.forename: George E
authors.initials: GE
authors.lastname: Barreto
authors.affiliation: Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, Recife, PE, Brazil. Electronic address: guedes.rca@gmail.com.
authors.forename: Rubem Carlos Araújo
authors.initials: RC
authors.lastname: Guedes
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D001930:Brain Injuries / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D002470:Cell Survival; D013181:Cortical Spreading Depression; D004734:Energy Metabolism; D018846:Excitatory Amino Acids / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000473:pathology / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D018846:Excitatory Amino Acids; D017382:Reactive Oxygen Species
keywords: Astrocytes; CSD; Neurons; TBI