title: Primary breast peripheral T-cell lymphoma not otherwise specified: report of a case.
abstract: Malignant lymphomas of the breast are rare and primary breast lymphoma comprises <0.5 % of breast malignancies, within which T-cell lymphomas are an even rarer subset. We report a case of primary breast peripheral T-cell lymphoma not otherwise specified (PTCL-NOS). Histology of the biopsied specimen revealed CD2(+), CD3(+), CD4(+), CD5(-), CD7(+), CD8(-), CD20(-), CD25(-), CD30(+), CD56(-), bcl-2(-), EBV-ISH(-), TIA-I(-), and ATLA negative. The patient was treated with six cycles of the CHOP regimen and died 17 months after the diagnosis was made, despite complete remission after conventional chemotherapy. To our knowledge, only 18 cases of primary peripheral T-cell lymphoma of the breast and just one previous case of primary PTCL-NOS of the breast have been reported in Japan.
authors.affiliation: Department of Surgery, University of Kurume Faculty of Medicine, 67 Asahi-machi, Kurume, Fukuoka, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Muroya
authors.forename: Uhi
authors.initials: U
authors.lastname: Toh
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Iwakuma
authors.forename: Shino
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Mai
authors.initials: M
authors.lastname: Mishima
authors.forename: Ryuji
authors.initials: R
authors.lastname: Takahashi
authors.forename: Miki
authors.initials: M
authors.lastname: Takenaka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shirouzu
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Agaki
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D003952:Diagnostic Imaging; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016411:Lymphoma, T-Cell, Peripheral / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone