title: Palladium-catalyzed double C-H activation: one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones from 5-pyrazolones and aryl iodides.
abstract: A palladium-catalyzed dual C-H activation to construct C-C/C-N bonds for one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones is successfully developed. This approach involves using a pyrazolone moiety as an internal directing group for C-H activation, and provides a flexible strategy to access this polycyclic skeleton.
authors.affiliation: CAS Key Laboratory of Receptor Research, and Synthetic Organic & Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences, Shanghai 201203, China. aozhang@simm.ac.cn.
authors.forename: Zhoulong
authors.initials: Z
authors.lastname: Fan
authors.forename: Kui
authors.initials: K
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Xing
authors.forename: Qizheng
authors.initials: Q
authors.lastname: Yao
authors.forename: Ao
authors.initials: A
authors.lastname: Zhang
mesh_terms: D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic; D006859:Hydrogen / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D047069:Pyrazolones / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D047069:Pyrazolones; C038362:pyrazolone; D010165:Palladium; D002244:Carbon; D006859:Hydrogen; D007455:Iodine