title: Asymmetric radical addition of TEMPO to titanium enolates.
abstract: A mild method for α-hydroxylation of N-acyl oxazolidinones by asymmetric radical addition of the 2,2,6,6-tetramethylpiperidine N-oxy (TEMPO) radical to titanium enolates was developed. The high diastereoselectivity and broad scope of the reaction show synthetic utility for the α-hydroxylation of substrates that are not tolerant to strongly basic conditions.
authors.affiliation: Department of Chemistry and Biochemistry, University of California , Santa Barbara, California 93106-9510, United States.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Mabe
authors.forename: Armen
authors.initials: A
authors.lastname: Zakarian