title: Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases.
abstract: Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates.
authors.affiliation: School of Pharmacy, University of Wisconsin-Madison, WI 53705, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Gan
authors.affiliation: School of Pharmacy, University of Wisconsin-Madison, WI 53705, USA; Waisman Center, University of Wisconsin-Madison, WI 53705, USA; Molecular and Environmental Toxicology Center, University of Wisconsin-Madison, WI 53705, USA; Center of Neuroscience, University of Wisconsin-Madison, WI 53705, USA. Electronic address: jajohnson@pharmacy.wisc.edu.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Johnson
mesh_terms: D000818:Animals; D061745:Antioxidant Response Elements / Q000235:genetics*; D006801:Humans; D051267:NF-E2-Related Factor 2 / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D051267:NF-E2-Related Factor 2; D018696:Neuroprotective Agents
keywords: Misfolded proteins; Neurodegenerative diseases; Nrf2-ARE pathway; Oxidative stress