title: Predictors of hypotension associated with propofol in trauma patients.
abstract: Propofol use may lead to hypotension in trauma patients intubated in the emergency department. In this study, predictors of hypotension were identified. We hypothesized that demographic variables could be associated with hypotension. Hypotension occurred in 33 of 200 patients. In the multivariate analysis, hypotension was associated with patient age greater than 55 years (odds ratios [OR], 3.61; 95% confidence interval [CI], 1.32-9.86; P = .012), obesity (OR, 2.66; 95% CI, 1.08-6.55; P = .034), and lower baseline blood pressure (OR, 1.59 [per 10-mm Hg decrease]; 95% CI, 1.29-1.96; P = .000). Age greater than 55 years, obesity, and lower baseline systolic blood pressure are associated with a higher risk of propofol-induced hypotension in trauma patients.
authors.affiliation: Department of Pharmacy Practice and Science, College of Pharmacy, University of Arizona, Tucson, Arizona (Drs Shearin, Patanwala, and Erstad); and Department of Surgery, College of Medicine, University of Arizona, Tucson, Arizona (Dr Tang).
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Shearin
authors.forename: Asad E
authors.initials: AE
authors.lastname: Patanwala
authors.forename: Andrew
authors.initials: A
authors.lastname: Tang
authors.forename: Brian L
authors.initials: BL
authors.lastname: Erstad
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D015331:Cohort Studies; D016001:Confidence Intervals; D005260:Female; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000453:epidemiology* / Q000503:physiopathology; D015994:Incidence; D007262:Infusions, Intravenous; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D015996:Survival Rate; D014193:Trauma Centers; D015599:Trauma Severity Indices; D014947:Wounds and Injuries / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality
chemical_list: D015742:Propofol