title: Evaluation of total adiponectin, adipocyte fatty acid binding protein and fibroblast growth factor 21 levels in individuals with metabolic syndrome.
abstract: Although many studies have investigated the relationships of several adipokines to metabolic syndrome (MetS), the interrelationships of adiponectin (ADP), adipocyte fatty acid binding protein (A-FABP) and fibroblast growth factor 21 (FGF 21) have not been described in detail. We examined 209 asymptomatic dyslipidemic patients divided into MetS+ (n=73) and MetS- (n=136) groups. The aim of study was to evaluate the relationships between observed adipokines, to compare the levels of total ADP, A-FABP and FGF 21 in individuals with and without MetS, and to elucidate the relationships of individual adipokines to lipid parameters, markers of insulin resistance and endothelial hemostatic markers in these groups. In MetS+ group, we found the independent positive association ADP with A-FABP (beta=0.4888, p=0.0382), A-FABP with FGF 21 (beta=0.3811, p=0.0002) and von Willebrand factor (beta=0.4502, p=0.0013), and FGF 21 with A-FABP (beta=0.4422, p=0.0002). Our study has confirmed the well-established risk profile of subjects with MetS, although clinically asymptomatic. MetS+ patients had also lower levels of ADP and higher levels of A-FABP and FGF 21. Our study evaluated the interrelationships of ADP, A-FABP and FGF 21 in asymptomatic dyslipidemic subjects with diagnosis of MetS. Especially strong association between A-FABP and FGF 21 needs to be clarified in further studies.
authors.affiliation: Department of Clinical Biochemistry, University Hospital Olomouc, Olomouc, Czech Republic. dalibor.novotny@fnol.cz.
authors.forename: D
authors.initials: D
authors.lastname: Novotny
authors.forename: H
authors.initials: H
authors.lastname: Vaverkova
authors.forename: D
authors.initials: D
authors.lastname: Karasek
authors.forename: J
authors.initials: J
authors.lastname: Lukes
authors.forename: L
authors.initials: L
authors.lastname: Slavik
authors.forename: P
authors.initials: P
authors.lastname: Malina
authors.forename: J
authors.initials: J
authors.lastname: Orsag
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood*; D050171:Dyslipidemias / Q000097:blood* / Q000175:diagnosis; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000175:diagnosis; D008875:Middle Aged
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors