title: Role of OmpA in the multidrug resistance phenotype of Acinetobacter baumannii.
abstract: Acinetobacter baumannii has emerged as a nosocomial pathogen with an increased prevalence of multidrug-resistant strains. The role of the outer membrane protein A (OmpA) in antimicrobial resistance remains poorly understood. In this report, disruption of the ompA gene led to decreased MICs of chloramphenicol, aztreonam, and nalidixic acid. We have characterized, for the first time, the contribution of OmpA in the antimicrobial resistance phenotype of A. baumannii.
authors.affiliation: Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Clinic Unit of Infectious Diseases, Microbiology and Preventive Medicine, Seville, Spain.
authors.forename: Younes
authors.initials: Y
authors.lastname: Smani
authors.forename: Anna
authors.initials: A
authors.lastname: Fàbrega
authors.forename: Ignasi
authors.initials: I
authors.lastname: Roca
authors.forename: Viviana
authors.initials: V
authors.lastname: Sánchez-Encinales
authors.forename: Jordi
authors.initials: J
authors.lastname: Vila
authors.forename: Jerónimo
authors.initials: J
authors.lastname: Pachón
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000502:physiology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; C078167:OMPA outer membrane proteins