title: [Multiple primary cancers of the esophagus and hepatocellular carcinoma-a report of 4 cases].
abstract: Esophageal cancer (EC) often occurs synchronously or metachronously with other primary cancers; however, the occurrence of multiple primary cancers (MPC) of the esophagus and hepatocellular carcinoma (HCC) is relatively rare. We reviewed the records of patients with MPC of the esophagus and HCC treated at our hospital during the past decade. Of the 537 EC patients, 126 (23.5%) had MPC. Of these 126 patients, 4 (3.2%) had MPC of the esophagus and HCC. MPC of the esophagus was synchronous in 1 patient and metachronous in the other 3. HCC was diagnosed by liver biopsy in 2 patients and by imaging studies in the other cases. The patient with synchronous MPC underwent surgery for MPC and HCC simultaneously and was alive 34 months later. We believe that liver tumors occurring with EC should be evaluated carefully by liver biopsy or imaging studies, and simultaneous surgery could be considered for the treatment of synchronous MPC of the esophagus and HCC.
authors.affiliation: Division of Digestive Surgery, Dept. of Surgery, Kyoto Prefectural University of Medicine.
authors.forename: Michihiro
authors.initials: M
authors.lastname: Kudou
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shiozaki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Konishi
authors.forename: Ryo
authors.initials: R
authors.lastname: Morimura
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Murayama
authors.forename: Shuhei
authors.initials: S
authors.lastname: Komatsu
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kuriu
authors.forename: Hisashi
authors.initials: H
authors.lastname: Ikoma
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kubota
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Chouhei
authors.initials: C
authors.lastname: Sakakura
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
mesh_terms: D000368:Aged; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome