title: Lipid hydroperoxide-derived modification of proteins in gastrointestinal tract.
abstract: Role of lipid peroxidation in the pathogenesis of gastrointestinal diseases has been evaluated by measuring the tissue levels of lipid peroxides as thiobarbituric acid-reactive substances in the animal models as well as human. Recently, N (ε)-(hexanoyl)lysine (HEL) and 4-hydroxy-2-nonenal (HNE) are recognized as reliable and sensitive biomarkers for the early phase and the late phase of lipid peroxidation, respectively. The presence of HNE- and HEL-modified proteins has been demonstrated in in vivo models of several gastrointestinal diseases. In the present review, we introduced HNE-modification of TRPV1 channel in esophageal epithelial cells, HEL-modification of tropomyosin 1 (TMP1) in gastric cancer cells, and HEL-modification of gastrokine 1 in the healing of gastric ulcer.
authors.affiliation: Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kamigyo-ku, Kyoto, 602-8566, Japan, ynaito@koto.kpu-m.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Takagi
authors.forename: Osamu
authors.initials: O
authors.lastname: Handa
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism*; D015415:Biomarkers; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000473:pathology; D000441:Hexanols / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000737:chemistry / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D018384:Oxidative Stress; D011506:Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D000447:Aldehydes; D015415:Biomarkers; D000441:Hexanols; D008054:Lipid Peroxides; D011506:Proteins; C027576:4-hydroxy-2-nonenal; D008239:Lysine