title: Evaluation of WO2013116562A, an orally active PI3Kδ inhibitor for the treatment of asthma.
abstract: (S)-4-amino-6-((1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile is claimed as a highly selective, PI3Kδ inhibitor. It is claimed to be useful in the treatment of asthma and appears intended for oral administration. It is shown to be well absorbed after oral administration and to have reasonable metabolic stability.
authors.affiliation: Norman Consulting , 18 Pink Lane, Burnham, Bucks, SL1 8JW , UK peter.norman2@btinternet.com.
authors.forename: Peter
authors.initials: P
authors.lastname: Norman
mesh_terms: D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D018501:Antirheumatic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D058534:Class I Phosphatidylinositol 3-Kinases / Q000037:antagonists & inhibitors*; D006801:Humans; D010330:Patents as Topic; D047428:Protein Kinase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D052999:Quinazolinones / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: C000593533:4-amino-6-((1-(5-chloro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile; D018927:Anti-Asthmatic Agents; D018501:Antirheumatic Agents; D047428:Protein Kinase Inhibitors; D052999:Quinazolinones; D058534:Class I Phosphatidylinositol 3-Kinases; C486018:PIK3CD protein, human