title: The triple power of D³: protein intrinsic disorder in degenerative diseases.
abstract: This review is an update of an article published four years ago (Uversky V.N. (2009) Intrinsically disordered proteins in neurodegenerative diseases: another illustration of the D² concept. Frontiers in Bioscience 14, 5188-5238). The major goal of this review is to show the interconnections between intrinsically disordered proteins (IDPs) and human neurodegeneration. This brings to existence a new D³ concept: protein intrinsic Disorder in neuroDegenerative Diseases. An important aspect of the D³ concept is that it deals with three D³'s, emphasizing that intrinsically Disordered proteins are abundantly found in various neuroDegenerative Diseases (the first D³), that these IDPs provoke neuroDegeneration due to their Dysfunctionality (the second D³), and that neuroDegeneration-related IDPs are often controlled by other Disordered proteins (the third D³).
authors.affiliation: Department of Molecular Medicine, University of South Florida, Morsani College of Medicine, 12901 Bruce B. Downs Blvd, MDC07, Tampa, Florida 33612.
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Uversky
mesh_terms: D006801:Humans; D064267:Intrinsically Disordered Proteins / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000503:physiopathology*
chemical_list: D064267:Intrinsically Disordered Proteins