title: Peptide-tunable drug cytotoxicity via one-step assembled polymer nanoparticles.
abstract: A novel class of nanoparticles is developed for the co-delivery of a short cell penetrating peptide and a chemotherapeutic drug to achieve enhanced cytotoxicity. Tunable cytotoxicity is achieved through non-toxic peptide-facilitated gating. The strategy relies on a one-step blending process from polymer building blocks to form monodisperse, PEGylated particles that are sensitive to cellular pH variations. By varying the amount of peptide loading, the chemotherapeutic effects can be enhanced by up to 30-fold.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: Kang
authors.initials: K
authors.lastname: Liang
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Richardson
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ejima
authors.forename: Georgina K
authors.initials: GK
authors.lastname: Such
authors.forename: Jiwei
authors.initials: J
authors.lastname: Cui
authors.forename: Frank
authors.initials: F
authors.lastname: Caruso
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D010455:Peptides; D011108:Polymers; D011109:Polymethacrylic Acids; C511861:poly(2-(diisopropylamino)ethyl methacrylate); D011092:Polyethylene Glycols; D004317:Doxorubicin
keywords: biomaterials; co-delivery; drug delivery; peptide; self-assembly