title: Application of C18-functional magnetic nanoparticles for extraction of aromatic amines from human urine.
abstract: In this paper, a novel method using C18-functional ultrafine magnetic silica nanoparticles (C18-UMS NPs) as adsorbents was developed for rapid extraction and enrichment of aromatic amines from urine. C18-UMS NPs were prepared by chemical coprecipitation, silanization and alkylation. The aromatic amines can be adsorbed on C18-UMS NPs and isolated easily from the matrix with an external magnetic field. After desorption with acetonitrile, the aromatic amines were determined by ultra fast liquid chromatography. The experimental parameters, such as pH value of sample solution, amount of C18-UMS NPs, extraction time, type and volume of desorption solvent, and desorption time were optimized. The analytical performances of the present method were also evaluated. The limits of detection for 1-aminonaphthalene, 4-aminobiphenyl, 4,4'-diaminodiphenylmethane and 4-aminophenylthioether were 1.3, 0.88, 1.1 and 1.1 ng mL(-1), respectively. The results showed that the present method was simple, highly efficient and rapid for the extraction and enrichment of aromatic amines from urine.
authors.affiliation: College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, PR China.
authors.forename: Chunzhu
authors.initials: C
authors.lastname: Jiang
authors.affiliation: College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, PR China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.affiliation: College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, PR China.
authors.forename: Xi
authors.initials: X
authors.lastname: Yu
authors.affiliation: College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gao
authors.affiliation: College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, PR China.
authors.forename: Yuanpeng
authors.initials: Y
authors.lastname: Wang
authors.affiliation: College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, PR China.
authors.forename: Hanqi
authors.initials: H
authors.lastname: Zhang
authors.affiliation: College of Chemistry, Jilin University, Qianjin Street 2699, Changchun 130012, PR China. Electronic address: songdq@jlu.edu.cn.
authors.forename: Daqian
authors.initials: D
authors.lastname: Song
mesh_terms: D000328:Adult; D000588:Amines / Q000302:isolation & purification* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D008297:Male; D052616:Solid Phase Extraction / Q000295:instrumentation / Q000379:methods*
chemical_list: D000588:Amines; D058185:Magnetite Nanoparticles
keywords: Aromatic amines; C(18)-functional ultrafine magnetic silica nanoparticles; Human urine; Magnetic solid-phase extraction; Ultra fast liquid chromatography