title: [Influence of ethnicity on the pharmacokinetics of amikacin].
abstract: OBJECTIVE
  Despite the increasing ethnic diversity, there are few studies of its influence on the pharmacokinetics of amikacin. The objective of this study was to compare the pharmacokinetics of amikacin in different populations: Asian, Hispanic, North Africans and Caucasian.
  
  
  METHODS
  A retrospective observational study was performed in a tertiary teaching hospital during eight years. It was included all patients with intravenous amikacin treatment in extended interval dosing regimen with therapeutic drug monitoring of amikacin. Pharmacokinetic parameters were analysed. A bivariate and multiple linear regression statistical analysis were carried out.
  
  
  RESULTS
  164 patients were included: 7 asians, 135 Caucasians, 11 Hispanics and 11 from North Africa. It was shown a lower plasma concentrations of amikacin in North Africa population due to its greater clearance.
  
  
  CONCLUSIONS
  Amikacin plasma concentrations monitoring is advisable in patients from North Africa in order to avoid subtherapeutic concentrations.
authors.affiliation: Melisa Barrantes-González, Departamento de Farmacia. Hospital del Mar. Universidad Autónoma de Barcelona. Passeig Marítim 25-29, 08003, Barcelona, Spain. melbarrantes@gmail.com.
authors.forename: Melisa
authors.initials: M
authors.lastname: Barrantes-González
authors.forename: Santiago
authors.initials: S
authors.lastname: Grau
authors.forename: David
authors.initials: D
authors.lastname: Conde-Estévez
authors.forename: Esther
authors.initials: E
authors.lastname: Salas
authors.forename: Mónica
authors.initials: M
authors.lastname: Marín-Casino
mesh_terms: D000328:Adult; D000352:Africa, Northern; D000367:Age Factors; D000368:Aged; D000583:Amikacin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D044466:Asian People; D044383:Black People; D003401:Creatine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005006:Ethnicity; D005260:Female; D006207:Half-Life; D006630:Hispanic or Latino; D006801:Humans; D007275:Injections, Intravenous; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012737:Sex Factors; D044465:White People
chemical_list: D000900:Anti-Bacterial Agents; D000583:Amikacin; D003401:Creatine