title: [Factors related to HIV-associated lipodystrophy among patients on antiretroviral therapy].
abstract: To describe the distribution and related risk factors of lipodystrophy (LD)among AIDS patients treated with antiretroviral drugs.
  
  
  METHODS
  A cross-sectional study was performed on 261 AIDS patients treated with antiretroviral drugs. All the subjects were followed in the Center for Disease Control and Prevention of two counties in northern Anhui province from May 25 to 30, 2012. Data related to demography, physical examination, history of antiretroviral treatment, HIV plasma viral load, and CD4 + T cell count were collected. Clinical examination was based on an assessment of changes in face, legs, arms, buttocks(peripheral sites), back, chest, neck or abdomen or change in waist size (central sites)as quoted by the clinicians.
  
  
  RESULTS
  LD was observed in 147 (56.3%) patients. The differences of age , gender, quality of sleep, weight and time of treatment between LD and non-lipodystrophy (NLD)groups were statistically significant (P < 0.05). Results from the Multivariate logistic regression analysis showed that the risk of women suffering from LD was 1.894 times of thd males (95%CI:1.075-3.338). The risk of those with LD showed an 1.448-fold increase regarding the time of treatment for each additional year (95%CI:1.267-1.654). Patients with poor quality of sleep were prone to LD with 11.901 times more than those with good quality of sleep (95%CI:2.701-52.441).
  
  
  CONCLUSIONS
  LD was commonly observed in AIDS patients who were under antiretroviral therapy. Gender, tine of treatment and the quality of sleep appeared the main factors related to the results of observation.
authors.affiliation: School of Public Health, Anhui Medical University, Hefei 230032, China.
authors.forename: An-ran
authors.initials: AR
authors.lastname: Jiang
authors.affiliation: School of Public Health, Anhui Medical University, Hefei 230032, China.
authors.forename: Qing-yan
authors.initials: QY
authors.lastname: Li
authors.affiliation: Linquan Center for Disease Control and Prevention of Anhui Province.
authors.forename: Jian-sheng
authors.initials: JS
authors.lastname: Chen
authors.affiliation: Anhui Provincial Center for Disease Control and Prevention.
authors.forename: Ai-wen
authors.initials: AW
authors.lastname: Liu
authors.affiliation: School of Public Health, Anhui Medical University, Hefei 230032, China.
authors.forename: Xing-yong
authors.initials: XY
authors.lastname: Tao
authors.affiliation: Anhui Provincial Center for Disease Control and Prevention.
authors.forename: Guo-ping
authors.initials: GP
authors.lastname: Ji
authors.affiliation: School of Public Health, Anhui Medical University, Hefei 230032, China. Email: lyc6266@163.com.
authors.forename: Ying-chun
authors.initials: YC
authors.lastname: Li
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000453:epidemiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D039682:HIV-Associated Lipodystrophy Syndrome / Q000453:epidemiology*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors