title: Encapsulation of a catalytic imidazolium salt into avidin: towards the development of a biohybrid catalyst active in ionic liquids.
abstract: Herein, we report the development of biohybrid catalysts that are capable of catalyzing the aldol reaction. The use of biotinylated imidazolium salts in combination with racemic or enantiomerically pure catalytic anions allowed us to study the adaptive and cooperative positioning of the anionic catalyst inside the protein. Supramolecular encapsulation of the biotinylated catalyst into avidin resulted in good selectivity for the aldol reaction performed in ionic liquid/water mixtures.
authors.affiliation: Departement de Chimie, Université de Montréal, C. P. 6128 Succursale Centre-Ville, Montréal, Québec H3C 3 J7 (Canada).
authors.forename: Vincent
authors.initials: V
authors.lastname: Gauchot
authors.forename: Mathieu
authors.initials: M
authors.lastname: Branca
authors.forename: Andreea
authors.initials: A
authors.lastname: Schmitzer
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001360:Avidin / Q000737:chemistry*; D019921:Biotinylation; D002384:Catalysis; D007093:Imidazoles / Q000737:chemistry*; D052578:Ionic Liquids / Q000737:chemistry*; D012492:Salts / Q000737:chemistry
chemical_list: D000447:Aldehydes; D007093:Imidazoles; D052578:Ionic Liquids; D012492:Salts; D001360:Avidin; C029899:imidazole; C116609:3-hydroxybutanal
keywords: aldol reaction; biotin-avidin; ionic liquids; supramolecular catalysis