title: Iron and aluminum in Alzheimer's disease.
abstract: In this case presentation, a woman with high serum levels of aluminum was treated with chelation therapy with deferoxamine and ascorbic acid. This patient was initially bedridden and the clinical situation was complicated by epileptic seizures. After the chelation therapy, the clinical condition was ameliorated and the therapy continued without the correlation to aluminum serum levels. The role of metals in neurodegenerative disorders and the correlation between iron metabolism and amyloid beta peptide are described. This case suggests chelation therapy could represent a promising therapeutic option for this dramatic disease.
authors.affiliation: "Ambulatorio Privato di Scienze Mediche", Valenzano, Bari, Italy. f.dilorenzo@email.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Lorenzo
authors.affiliation: "Ambulatorio Privato di Scienze Mediche", Valenzano, Bari, Italy.
authors.forename: Berardino
authors.initials: B
authors.lastname: Di Lorenzo
mesh_terms: D000368:Aged; D000535:Aluminum / Q000097:blood*; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism*; D000975:Antioxidants / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D015913:Chelation Therapy / Q000379:methods*; D003676:Deferoxamine / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood*; D017262:Siderophores / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D017262:Siderophores; D000535:Aluminum; D007501:Iron; D003676:Deferoxamine; D001205:Ascorbic Acid