title: [Peculiarities of sexual behavior of female rats with hyperandrogenia in pubertal and postpubertal periods].
abstract: The parameters of female and male sexual behavior in 3- and 6- month old female rats which were exposed to an androgen excess (subcutaneous implantation of Silastic capsules containing 5 mg of crystalline testosterone) from the beginning of pubertal period (at the age of 35 days), or within postpubertal period (at the age of 4 months). Hyperandrogenia in pubertal period had no effect on female sexual behavior formation, but it led to appearance of male behavior components in 100% of animals. In female rats which were implanted with testosterone capsules in postpubertal period, sexual disturbances were more pronounced and were characterized by masculinization and defeminization, which was due to a higher degree of androgenic saturation. The data obtained suggest a leading role of hyperandrogenemia in the pathogenesis of sexual behavior disturbances in female rats in different periods of individual development.
authors.forename: N D
authors.initials: ND
authors.lastname: Nosenko
authors.forename: A A
authors.initials: AA
authors.lastname: Lymarieva
mesh_terms: D000367:Age Factors; D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D003692:Delayed-Action Preparations; D005260:Female; D017588:Hyperandrogenism / Q000139:chemically induced / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012741:Sexual Maturation / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D000728:Androgens; D003692:Delayed-Action Preparations; D013739:Testosterone