title: Boron neutron capture therapy as new treatment for clear cell sarcoma: trial on different animal model.
abstract: Clear cell sarcoma (CCS) is a rare malignant tumor with a poor prognosis. In our previous study, the tumor disappeared under boron neutron capture therapy (BNCT) on subcutaneously-transplanted CCS-bearing animals. In the present study, the tumor disappeared under this therapy on model mice intramuscularly implanted with three different human CCS cells. BNCT led to the suppression of tumor-growth in each of the different model mice, suggesting its potentiality as an alternative to, or integrative option for, the treatment of CCS.
authors.affiliation: Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
authors.forename: Tooru
authors.initials: T
authors.lastname: Andoh
authors.affiliation: Department of Orthopaedic Surgery, Hyogo Cancer Center, Akashi 673-8558, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Fujimoto
authors.affiliation: Section of Translational Research, Hyogo Cancer Center, Akashi 673-8558, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sudo
authors.affiliation: Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Division of Radiation Life Science, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.affiliation: Department of Pathology, Hyogo Cancer Center, Akashi 673-8558, Japan.
authors.forename: Toshiko
authors.initials: T
authors.lastname: Sakuma
authors.affiliation: Division of Pediatrics, University of Miyazaki, Miyazaki 889-1692, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moritake
authors.affiliation: Department of Pediatrics, Saiseikai Shigaken Hospital, Ritto 520-3046, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Sugimoto
authors.affiliation: Department of Immunopathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Takeuchi
authors.affiliation: Department of Clinical Laboratory, Chugoku Central Hospital, Fukuyama 720-0001, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sonobe
authors.affiliation: Department of Pathology, USC Keck School of Medicine, Los Angeles, CA 90033, USA.
authors.forename: Alan L
authors.initials: AL
authors.lastname: Epstein
authors.affiliation: Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Fukumori
authors.affiliation: Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Sennan-gun 590-0494, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.affiliation: Faculty of Pharmaceutical Sciences and Cooperative Research Center of Life Sciences, Kobe Gakuin University, Kobe 650-8586, Japan. Electronic address: ichikawa@pharm.kobegakuin.ac.jp.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ichikawa
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D008657:Metabolic Clearance Rate; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D019042:Muscle Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*; D009928:Organ Specificity; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D018227:Sarcoma, Clear Cell / Q000378:metabolism* / Q000532:radiotherapy*; D014018:Tissue Distribution; D016896:Treatment Outcome
chemical_list: D001896:Boron Compounds; D010649:Phenylalanine; C033685:4-boronophenylalanine
keywords: Biodistribution; Boron neutron capture therapy (BNCT); Clear cell sarcoma (CCS); Neutron irradiation; p-Borono-l-phenylalanine (l-BPA)