title: [A case of pathologically complete response of local recurrence in the mesorectum after multidisciplinary therapy].
abstract: The patient was a 68-year-old man who had undergone sigmoidectomy 1 year previously. Adjuvant therapy with tegafur- uraci(l UFT) and Leucovorin( UZEL) was administered. Seven months later, the carcinoembryonic antigen( CEA) level increased to 7.5 ng/mL. Enhanced computed tomography (CT) revealed a 4-cm mass in the mesorectum, and the patient was diagnosed as having local recurrence. Chemotherapy with oxaliplatin, 5-fluorouracil, and Leucovorin( mFOLFOX6) and radiation therapy( 60 Gy) were administered. As the tumor could not be detected after chemoradiotherapy, abdominoperineal resection was performed. Pathological examination showed no cancer and indicated a complete response. The patients CEA level has not increased and no recurrence has been detected on enhanced CT for 3.5 years. The tumor could be decreased in size by chemoradiotherapy and the operation could be safely performed without resecting other organs. Although surgery is generally performed for local recurrence, multidisciplinary therapy could be useful in performing such surgery safely.
authors.affiliation: Dept. of Surgical Oncology, Graduate School, Tokyo Medical and Dental University.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ishiba
authors.forename: Shunro
authors.initials: S
authors.lastname: Ohtsukasa
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kato
authors.forename: Hiroto
authors.initials: H
authors.lastname: Nagano
authors.forename: Susumu
authors.initials: S
authors.lastname: Takamatsu
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Taki
authors.forename: Yuu
authors.initials: Y
authors.lastname: Hiraoka
authors.forename: Hideaki
authors.initials: H
authors.lastname: Murase
authors.forename: Megumi
authors.initials: M
authors.lastname: Enjoji
authors.forename: Shinya
authors.initials: S
authors.lastname: Ishimaru
authors.forename: Ryo
authors.initials: R
authors.lastname: Ono
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kawachi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D006801:Humans; D008297:Male; D012004:Rectal Neoplasms / Q000556:secondary / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction; D012811:Sigmoid Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery