title: Clinical features and management of BRCA1 and BRCA2-associated prostate cancer.
abstract: It is thought that over forty percent of an individual's risk of developing prostate cancer (PCa) is related to familial and genetic factors. Although multiple genes have been implicated in the development of PCa, few confer as high a risk as mutations in the genes associated with early-onset breast cancer (BRCA1 and BRCA2). Not only do mutations in BRCA genes increase the risk of PCa, but they have also been related to adverse disease characteristics and outcomes. Therefore, a better understanding of the association between BRCA gene mutations and PCa may provide the backdrop for individualized management of patients with PCa who are carriers of a gene mutation. Such management may include an individualized approach to screening and treatment including chemotherapeutic regimens targeted to the underlying genetic mechanism of disease. In this paper, we review the evidence relating BRCA gene mutations to the risk of PCa, as well as outcomes and response to therapy, and suggest an approach to the management of such patients.
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY.
authors.forename: Shaheen R
authors.initials: SR
authors.lastname: Alanee
authors.affiliation: Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY.
authors.forename: Emily A
authors.initials: EA
authors.lastname: Glogowski
authors.affiliation: Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY.
authors.forename: Kasmintan A
authors.initials: KA
authors.lastname: Schrader
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY.
authors.forename: James A
authors.initials: JA
authors.lastname: Eastham
authors.affiliation: Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY.
authors.forename: Kenneth
authors.initials: K
authors.lastname: Offit
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein / Q000235:genetics*; D063646:Carcinogenesis / Q000235:genetics*; D005817:Genetic Counseling / Q000379:methods / Q000639:trends; D005820:Genetic Testing / Q000379:methods / Q000639:trends; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000628:therapy*; D012017:Referral and Consultation / Q000639:trends; D018570:Risk Assessment / Q000379:methods
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D024682:BRCA2 Protein; C551750:BRCA2 protein, human