title: Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats.
abstract: Sulfur dioxide (SO2) regulates many physiological processes. Little is known about its roles in neurological disorders. In this study, we investigated the role of endogenous SO2 in the development of febrile seizures (FS) and related brain damages. In the rat model of recurrent FS, we found that endogenous SO2 in the plasma and hippocampus was increased, accompanied by upregulation of aspartate amino-transferase 1 (AAT1) and AAT2, and neuronal apoptosis and mossy fiber sprouting (MFS) in the hippocampus. Preconditioning with low concentration of SO2 (1-10 μmol/kg) alleviated the neuronal damage, and attenuated neuronal apoptosis and MFS, whereas preconditioning with high concentration of SO2 (100 μmol/kg) or inhibition of AAT aggravated the neuronal damage, and promoted neuronal apoptosis and MFS in hippocampus of rats with recurrent FS. These data indicate that endogenous SO2 is involved in the development of FS and related brain damage. Preconditioning with low concentration of SO2 may protect neurons from toxicity caused by FS.
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Wenxia
authors.initials: W
authors.lastname: Yi
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. Electronic address: qinjiong@263.net.
authors.forename: Jiong
authors.initials: J
authors.lastname: Qin
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
authors.forename: Xingzhi
authors.initials: X
authors.lastname: Chang
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D024443:Aspartate Aminotransferase, Cytoplasmic / Q000378:metabolism; D024442:Aspartate Aminotransferase, Mitochondrial / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D017207:Rats, Sprague-Dawley; D012008:Recurrence; D003294:Seizures, Febrile / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D013458:Sulfur Dioxide / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D013458:Sulfur Dioxide; D024443:Aspartate Aminotransferase, Cytoplasmic; D024442:Aspartate Aminotransferase, Mitochondrial
keywords: Aspartate aminotransferase; Brain damage; Febrile seizures; Sulfur dioxide