title: Truncated norzoanthamine exhibiting similar collagen protection activity, toward a promising anti-osteoporotic drug.
abstract: The marine alkaloid, norzoanthamine, is considered to be a promising drug for osteoporosis treatment. Due to its rarity and complicated structure, a practical supply method must be developed. Here, we designed a truncated norzoanthamine, which has two-thirds of the original structure, and found that it exhibited similar collagen protection activity.
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Inoue
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hidaka
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: seketsuf@chem.s.u-tokyo.ac.jp.
authors.forename: Seketsu
authors.initials: S
authors.lastname: Fukuzawa
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tachibana
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D000818:Animals; D001381:Azepines / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D010024:Osteoporosis / Q000188:drug therapy / Q000378:metabolism; D011161:Porifera; D011804:Quinolines / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D001381:Azepines; D006576:Heterocyclic Compounds, 4 or More Rings; D011804:Quinolines; C400280:norzoanthamine; D003094:Collagen
keywords: Alkaloid; Collagen; Norzoanthamine; Osteoporosis