title: Comparison of creatine supplementation before versus after supervised resistance training in healthy older adults.
abstract: This study was performed to compare the effects of creatine supplementation (CR) before vs. after supervised resistance training (RT) in healthy older adults. Participants were randomized to one of two groups: CR-Before (0.1g•kg(-1) creatine before + 0.1g•kg(-1) placebo [rice flour] after RT, n = 11) or CR-After (placebo before + creatine after RT, n = 11). Resistance training (RT) was performed 3 days/week, on nonconsecutive days, for 12 weeks. Prior to and following the study, measures were taken for body composition, maximum strength, muscle protein catabolism, and kidney function. Over the 12-week training period, both groups experienced a significant increase in whole-body lean tissue mass, limb muscle thickness, and upper and lower body strength and a decrease in muscle protein catabolism (p < 0.001), with no differences between groups. There was no change in kidney function over time. Changes in muscle mass or strength are similar when creatine is ingested before or after supervised resistance training in older adults.
authors.affiliation: a Faculty of Kinesiology and Health Studies, University of Regina , Regina , Saskatchewan , Canada.
authors.forename: Darren G
authors.initials: DG
authors.lastname: Candow
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Zello
authors.forename: Binbing
authors.initials: B
authors.lastname: Ling
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Farthing
authors.forename: Philip D
authors.initials: PD
authors.lastname: Chilibeck
authors.forename: Katherine
authors.initials: K
authors.lastname: McLeod
authors.forename: Jonathan
authors.initials: J
authors.lastname: Harris
authors.forename: Shanthi
authors.initials: S
authors.lastname: Johnson
mesh_terms: D003401:Creatine / Q000008:administration & dosage*; D019587:Dietary Supplements; D004144:Diosgenin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000187:drug effects*; D005082:Physical Exertion / Q000187:drug effects*; D010840:Phytosterols / Q000008:administration & dosage*; D055070:Resistance Training / Q000379:methods*
chemical_list: D010840:Phytosterols; C404755:dietary supplement, SPORT; D004144:Diosgenin; D003401:Creatine