title: Calysolins V-IX, resin glycosides from Calystegia soldanella and their antiviral activity toward herpes.
abstract: Five new resin glycosides having macrolactone structures (jalapins), named calysolins V-IX (1-5), were isolated from the leaves, stems, and roots of Calystegia soldanella ROEM. et SCHULT. (Convolvulaceae). Their structures were determined on the basis of spectroscopic data as well as chemical evidence. The isolated compounds could be classified into two macrolactone types-one having a 22-membered ring (1-4) and the other with a 27-membered ring (5). The sugar moieties of 1-5 were found to exist in partially acylated forms comprising 2S-methylbutyric acid and tiglic acid. Compounds 4 and 5 are the first representatives of the calysolic acid C as the component glycosidic acid. Additionally, the antiviral activity of 1-5, together with calysolins I-IV and soldanelline B, which are previously isolated jalapins from this plant, toward herpes simplex virus type 1 was evaluated. All the compounds showed antiviral activity.
authors.affiliation: School of Agriculture, Tokai University.
authors.forename: Masateru
authors.initials: M
authors.lastname: Ono
authors.forename: Ayako
authors.initials: A
authors.lastname: Takigawa
authors.forename: Yukiyo
authors.initials: Y
authors.lastname: Kanemaru
authors.forename: Gen
authors.initials: G
authors.lastname: Kawakami
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kabata
authors.forename: Masafumi
authors.initials: M
authors.lastname: Okawa
authors.forename: Junei
authors.initials: J
authors.lastname: Kinjo
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yokomizo
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Yoshimitsu
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Nohara
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D031253:Calystegia / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology; D012116:Resins, Plant / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D006027:Glycosides; D007783:Lactones; D012116:Resins, Plant