title: Hoarding disorder and obsessive-compulsive disorder show different patterns of neural activity during response inhibition.
abstract: Although hoarding disorder (HD) has been historically conceptualized as a subtype or dimension of obsessive-compulsive disorder (OCD), preliminary evidence suggests that these two disorders have distinct neural underpinnings. The aim of the present study was to compare the hemodynamic responses of HD patients, OCD patients, and healthy controls (HC) during response inhibition on a high-conflict Go/NoGo task that has previously proved sensitive to OCD. Participants comprised 24 HD patients, 24 OCD patients, and 24 HCs who completed a Go/NoGo task during functional magnetic resonance imaging (fMRI). Although behavioral data showed no difference among the groups in Go/NoGo task performance, significant differences in hemodynamic activity were noted. During correct rejects (successful response inhibition), HD patients showed greater right precentral gyrus activation, whereas OCD patients exhibited greater right orbitofrontal activation, as assessed using a region of interest approach. During errors of commission (response inhibition failures), OCD patients, but not HD patients, were characterized by excessive activity in left and right orbitofrontal gyrus. The present results lend further support to the biological distinction between HD and OCD, and they are consistent with previous research suggesting frontal hypoactivity in HD patients during hoarding-unrelated tasks.
authors.affiliation: The Institute of Living and Yale University School of Medicine, 200 Retreat Avenue, Hartford, CT 06106, USA. Electronic address: david.tolin@hhchealth.org.
authors.forename: David F
authors.initials: DF
authors.lastname: Tolin
authors.affiliation: The Institute of Living and Yale University School of Medicine, 200 Retreat Avenue, Hartford, CT 06106, USA.
authors.forename: Suzanne T
authors.initials: ST
authors.lastname: Witt
authors.affiliation: The Institute of Living and Yale University School of Medicine, 200 Retreat Avenue, Hartford, CT 06106, USA.
authors.forename: Michael C
authors.initials: MC
authors.lastname: Stevens
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006439:Hemodynamics; D000067836:Hoarding Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology*; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology
keywords: Functional magnetic resonance imaging (fMRI); Hoarding; Inhibition; Neuroimaging; Obsessive–compulsive disorder