title: Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions.
abstract: A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two-step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2-aminoquinoxalines in high yields.
authors.affiliation: Department of Chemistry, Korea University , Anam-ro, Seongbuk-gu, Seoul 136701, Republic of Korea.
authors.forename: Yeon-Ho
authors.initials: YH
authors.lastname: Cho
authors.forename: Kyung-Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Cheol-Hong
authors.initials: CH
authors.lastname: Cheon
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011810:Quinoxalines / Q000138:chemical synthesis*
chemical_list: C403606:2-aminoquinoxaline; D000447:Aldehydes; D003486:Cyanides; D011810:Quinoxalines