title: Regulation of lipoprotein lipase by Angptl4.
abstract: Triglyceride (TG)-rich chylomicrons and very low density lipoproteins (VLDL) distribute fatty acids (FA) to various tissues by interacting with the enzyme lipoprotein lipase (LPL). The protein angiopoietin-like 4 (Angptl4) is under sensitive transcriptional control by FA and the FA-activated peroxisome proliferator activated receptors (PPARs), and its tissue expression largely overlaps with that of LPL. Growing evidence indicates that Angptl4 mediates the physiological fluctuations in LPL activity, including the decrease in adipose tissue LPL activity during fasting. This review focuses on the major ambiguities concerning the mechanism of LPL inhibition by Angptl4, as well as on the physiological role of Angptl4 in lipid metabolism, highlighting its function in a variety of tissues, and uses this information to make suggestions for further research.
authors.affiliation: Nutrition, Metabolism, and Genomics group, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands.
authors.forename: Wieneke
authors.initials: W
authors.lastname: Dijk
authors.affiliation: Nutrition, Metabolism, and Genomics group, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands. Electronic address: sander.kersten@wur.nl.
authors.forename: Sander
authors.initials: S
authors.lastname: Kersten
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins / Q000235:genetics / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D043484:Proprotein Convertases / Q000235:genetics / Q000378:metabolism
chemical_list: C474772:ANGPTL4 protein, human; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins; D005227:Fatty Acids; D047492:Peroxisome Proliferator-Activated Receptors; D008071:Lipoprotein Lipase; D043484:Proprotein Convertases
keywords: angiopoietin-like 4; glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein; hypertriglyceridemia; lipoprotein lipase; proprotein convertases