title: [Effects of melaxen and valdoxan on the activity of glutathione antioxidant system and NADPH-producing enzymes in rat heart under experimental hyperthyroidism conditions].
abstract: The effects of melaxen and valdoxan on the activity of glutathione antioxidant system and some NADPH-producing enzymes have been studied under conditions of experimental hyperthyroidism in rat heart. Under the action of these drugs, reduced glutathione (GSH) content increased as compared to values observed under the conditions of pathology. It has been established that the activities of glutathione reductase (GR), glutathione peroxidase (GP), glucose-6-phosphate dehydrogenase, and NADP isocitrate dehydrogenase (increased under pathological conditions) change toward the intact control values upon the introduction of both drugs. The influence of melaxen and valdoxan, capable of producing antioxidant effect, leads apparently to the inhibition of free-radical oxidation processes and, as a consequence, the reduction of mobilization degree of the glutathione antioxidant system.
authors.forename: M V
authors.initials: MV
authors.lastname: Gorbenko
authors.forename: T N
authors.initials: TN
authors.lastname: Popova
authors.forename: K K
authors.initials: KK
authors.lastname: Shul'gin
authors.forename: S S
authors.initials: SS
authors.lastname: Popov
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000819:agonists / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006980:Hyperthyroidism / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D009249:NADP / Q000378:metabolism*; D051381:Rats; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism; D014284:Triiodothyronine; D009281:Naphthalenes
chemical_list: D000081:Acetamides; D000975:Antioxidants; D005954:Glucosephosphate Dehydrogenase; D005978:Glutathione; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D007521:Isocitrate Dehydrogenase; D008550:Melatonin; D009249:NADP; D017382:Reactive Oxygen Species; D014284:Triiodothyronine; C084711:agomelatine; D009281:Naphthalenes; C039355:isocitrate dehydrogenase (NADP+)