title: [A case of carcinoma associated with anal fistula effectively treated with preoperative chemoradiotherapy].
abstract: A 60-year-old man presented with anal pain. He was diagnosed as having perianal abscess and carcinoma associated with anal fistula. We performed chemoradiotherapy (radiation, total 50.4 Gy; capecitabine 2,000 mg/m2) followed by chemotherapy( XELOX, 2 courses: capecitabine 2,000 mg/m2, oxaliplatin 130 mg/m2). After chemoradiotherapy, the tumor significantly reduced in size. Laparoscopic abdominoperineal resection of the rectum, extended resection of the perianal region, and reconstruction of the perianal skin defect using a rectus abdominis musculocutaneous flap were performed. Histopathologically, the tumor was classified as tub2, pMP, ly0, v0, pN0 (0/3), pStage I, and the therapeutic efficacy was classified as Grade 2. Chemoradiation appears to be effective for the treatment of carcinomas associated with anal fistula.
authors.affiliation: Dept. of Surgery, Suita Municipal Hospital.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Nishigaki
authors.forename: Kohei
authors.initials: K
authors.lastname: Murata
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Okubo
authors.forename: Koji
authors.initials: K
authors.lastname: Mikami
authors.forename: Syu
authors.initials: S
authors.lastname: Okamura
authors.forename: Yuma
authors.initials: Y
authors.lastname: Wada
authors.forename: Ryo
authors.initials: R
authors.lastname: Kato
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Makino
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Okada
authors.forename: Nariaki
authors.initials: N
authors.lastname: Fukuchi
authors.forename: Chikara
authors.initials: C
authors.lastname: Ebisui
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Kinuta
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012003:Rectal Fistula / Q000209:etiology / Q000601:surgery*; D012004:Rectal Neoplasms / Q000150:complications / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents