title: Local plasticity of dendritic excitability can be autonomous of synaptic plasticity and regulated by activity-based phosphorylation of Kv4.2.
abstract: While plasticity is typically associated with persistent modifications of synaptic strengths, recent studies indicated that modulations of dendritic excitability may form the other part of the engram and dynamically affect computational processing and output of neuronal circuits. However it remains unknown whether modulation of dendritic excitability is controlled by synaptic changes or whether it can be distinct from them. Here we report the first observation of the induction of a persistent plastic decrease in dendritic excitability decoupled from synaptic stimulation, which is localized and purely activity-based. In rats this local plasticity decrease is conferred by CamKII mediated phosphorylation of A-type potassium channels upon interaction of a back propagating action potential (bAP) with dendritic depolarization.
authors.affiliation: Nano-scale Science and Engineering Center, Berkeley, California, United States of America ; Biophysics Program, University of California Berkeley, California, United States of America.
authors.forename: Anna
authors.initials: A
authors.lastname: Labno
authors.affiliation: Nano-scale Science and Engineering Center, Berkeley, California, United States of America.
authors.forename: Ajithkumar
authors.initials: A
authors.lastname: Warrier
authors.affiliation: Nano-scale Science and Engineering Center, Berkeley, California, United States of America.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.affiliation: Nano-scale Science and Engineering Center, Berkeley, California, United States of America.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism; D003712:Dendrites / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005260:Female; D006624:Hippocampus / Q000502:physiology; D036881:Long-Term Synaptic Depression; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D010766:Phosphorylation; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D051672:Shal Potassium Channels / Q000378:metabolism*; D013569:Synapses / Q000502:physiology*; D055366:Synaptic Potentials
chemical_list: D051672:Shal Potassium Channels; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D048049:Extracellular Signal-Regulated MAP Kinases