title: Transformation of a primitive myxoid mesenchymal tumor of infancy to an undifferentiated sarcoma: a first reported case.
abstract: An 8-month-old girl underwent surgical resection of a cervical mass with histologic diagnosis of a primitive myxoid mesenchymal tumor of infancy (PMMTI). More than 5 years after the initial surgical intervention, the tumor recurred locally, with numerous distant metastases. The histologic morphology of this tumor was compatible with a diagnosis of an undifferentiated high-grade sarcoma. PMMTI is a recently described poorly differentiated fibroblastic soft-tissue tumor of infancy, of at least borderline biological behavior, characterized by local recurrence and a potential to metastasize. We present here the first case of a transformation of a PMMTI into an undifferentiated high-grade sarcoma.
authors.affiliation: Departments of *Pathology ∥Surgery, CHU Sainte-Justine §Department of Pediatrics, Division of Hematology-Oncology, CHU Ste-Justine †Department of Pathology and Cellular Biology, Université de Montréal ¶Department of Surgery, Hôpital du Sacré-Coeur de Montréal, Montréal, QC, Canada ‡Division of Clinical Pathology, Hôpitaux Universitaires de Genève, Switzerland.
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Guilbert
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Rougemont
authors.forename: Yvan
authors.initials: Y
authors.lastname: Samson
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Mac-Thiong
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Fournet
authors.forename: Dorothee Bouron-Dal
authors.initials: DB
authors.lastname: Soglio
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007223:Infant; D008637:Mesenchymoma / Q000188:drug therapy / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology*; D011379:Prognosis; D012509:Sarcoma / Q000188:drug therapy / Q000556:secondary*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000473:pathology*