title: Development of thiadiazole as an antidiabetic agent- a review.
abstract: This review provides a brief summary of thiadiazole ring containing compounds as antidiabetic agents. It covers the most active thiadiazole derivatives selected from reported literature of thiadiazole system as antidiabetic drug substance in the form of synthesis and structural activity relationship study reports. Some of the promising thiadiazole compounds interacting with targets such as sodium-glucose linked transporter, peroxisome proliferator-activated receptor, protein tyrosine phosphatase, c-Jun N-terminal kinase, dipeptidyl peptidase-4 and cannabinoid-1 receptor have been collected with their biological potency. The information provided in this review acts as important overview for medicinal chemist to develop a new chemical entity possessing antidiabetic activity.
authors.forename: Prasanna A
authors.initials: PA
authors.lastname: Datar
authors.affiliation: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, Narhe, Pune-400041, India. d_pras_anna@rediffmail.com.
authors.forename: Tejashree A
authors.initials: TA
authors.lastname: Deokule
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors / Q000378:metabolism; D018819:Dipeptidyl Peptidase 4 / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D015394:Molecular Structure; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism; D022702:Receptors, Adrenergic, beta-3 / Q000378:metabolism; D018100:Receptors, Histamine H3 / Q000378:metabolism; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D047492:Peroxisome Proliferator-Activated Receptors; D022702:Receptors, Adrenergic, beta-3; D018100:Receptors, Histamine H3; D013830:Thiadiazoles; D051048:Diacylglycerol O-Acyltransferase; D048031:JNK Mitogen-Activated Protein Kinases; D017027:Protein Tyrosine Phosphatases; D018819:Dipeptidyl Peptidase 4