title: TET family proteins: new players in gliomas.
abstract: DNA methylation at the 5-position of cytosine (5mC) in the mammalian genome has emerged as a pivotal epigenetic event that plays important roles in development, aging and disease. The three members of the TET protein family, which convert 5mC to 5-hydroxymethylcytosine, has provided a potential mechanism resulting in DNA demethylation and maintaining cellular identity. Recent studies have shown that epigenetic modifications play a key role in the regulation of the molecular pathogenesis of gliomas. In this review we focus on demonstrating the TET proteins in DNA demethylation and transcriptional regulation of different target genes. In addition, we address the role of TET proteins in gliomas. This review will provide valuable insights into the potential targets of gliomas, and may open the possibility of novel therapeutic approaches to this fatal disease.
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
authors.forename: Er-Bao
authors.initials: EB
authors.lastname: Bian
authors.forename: Gang
authors.initials: G
authors.lastname: Zong
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Xie
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Meng
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism*; D019175:DNA Methylation; D004268:DNA-Binding Proteins; D049308:Dioxygenases; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D006899:Mixed Function Oxygenases; D011518:Proto-Oncogene Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D006899:Mixed Function Oxygenases; C462539:TET1 protein, human; C578792:TET3 protein, human; D049308:Dioxygenases; C541081:TET2 protein, human