title: Nickel hydroxide nanoparticles-reduced graphene oxide nanosheets film: layer-by-layer electrochemical preparation, characterization and rifampicin sensory application.
abstract: Electrochemical deposition, as a well-controlled synthesis procedure, has been used for subsequently layer-by-layer preparation of nickel hydroxide nanoparticle-reduced graphene oxide nanosheets (Ni(OH)2-RGO) on a graphene oxide (GO) film pre-cast on a glassy carbon electrode surface. The surface morphology and nature of the nano-hybrid film (Ni(OH)2-RGO) was thoroughly characterized by scanning electron and atomic force microscopy, spectroscopy and electrochemical techniques. The modified electrode appeared as an effective electro-catalytic model for analysis of rifampicin (RIF) by using linear sweep voltammetry (LSV). The prepared modified electrode exhibited a distinctly higher activity for electro-oxidation of RIF than either GO, RGO nanosheets or Ni(OH)2 nanoparticles. Enhancement of peak currents is ascribed to the fast heterogeneous electron transfer kinetics that arise from the synergistic coupling between the excellent properties of RGO nanosheets (such as high density of edge plane sites, subtle electronic characteristics and attractive π-π interaction) and unique properties of metal nanoparticles. Under the optimized analysis conditions, the modified electrode showed two oxidation processes for rifampicin at potentials about 0.08 V (peak I) and 0.69 V (peak II) in buffer solution of pH 7.0 with a wide linear dynamic range of 0.006-10.0 µmol L(-1) and 0.04-10 µmol L(-1) with a detection limit of 4.16 nmol L(-1) and 2.34 nmol L(-1) considering peaks I and II as an analytical signal, respectively. The results proved the efficacy of the fabricated modified electrode for simple, low cost and highly sensitive medicine sensor well suited for the accurate determinations of trace amounts of rifampicin in the pharmaceutical and clinical preparations.
authors.affiliation: Department of Chemistry, Sharif University of Technology, Tehran 11155-9516, Iran.
authors.forename: Shokoufeh
authors.initials: S
authors.lastname: Rastgar
authors.affiliation: Department of Chemistry, Sharif University of Technology, Tehran 11155-9516, Iran; Institute for Nanoscience and Technology, Sharif University of Technology, Tehran, Iran. Electronic address: shahrokhian@sharif.edu.
authors.forename: Saeed
authors.initials: S
authors.lastname: Shahrokhian
mesh_terms: D000904:Antibiotics, Antitubercular / Q000032:analysis*; D055664:Electrochemical Techniques / Q000379:methods*; D006108:Graphite / Q000737:chemistry*; D053768:Metal Nanoparticles; D008855:Microscopy, Electron, Scanning; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D012293:Rifampin / Q000032:analysis*
chemical_list: D000904:Antibiotics, Antitubercular; D006108:Graphite; D009532:Nickel; C028007:nickel monoxide; D012293:Rifampin
keywords: Graphene oxide; Nickel hydroxide nanoparticles; Reduced graphene oxide; Rifampicin