title: Emergence of molecular imaging of aortic aneurysm: implications for risk stratification and management.
abstract: Imaging cellular and molecular processes associated with aneurysm expansion, dissection, and rupture can potentially transform the management of patients with thoracic and abdominal aortic aneurysm. Here, we review recent advances in molecular imaging of aortic aneurysm, focusing on imaging modalities with the greatest potential for clinical translation and application, PET, SPECT, and MRI. Inflammation (e.g., with (18)F-FDG, nanoparticles) and matrix remodeling (e.g., with matrix metalloproteinase-targeted tracers) are highlighted as promising targets for molecular imaging of aneurysm. Potential alternative or complementary approaches to molecular imaging for aneurysm risk stratification are briefly discussed.
authors.affiliation: Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine and Yale Cardiovascular Research Center, Yale University School of Medicine, New Haven, CT, USA.
authors.forename: Reza
authors.initials: R
authors.lastname: Golestani
authors.forename: Mehran M
authors.initials: MM
authors.lastname: Sadeghi
mesh_terms: D001014:Aortic Aneurysm / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy; D015415:Biomarkers / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D007155:Immunologic Factors / Q000378:metabolism*; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends; D018570:Risk Assessment
chemical_list: D015415:Biomarkers; D016207:Cytokines; D007155:Immunologic Factors