title: [Influence of intranasal administration of dopamine on realization of cognitive processes and locomotor activity of rats during stress].
abstract: In spontanepously hypertensive rats (SHR) we studied the influence of intranasal administration of dopamine (DA) on realization of food operant conditioned reflex (OCR) and motor activity (locomotion, bars, stopping beating, grooming) in a interstimulation period in a norm and in the conditions of stressed influences. The state of sharp stress was caused by application of intensive acoustic irritation is a loud sound operating during realization ofOCR. Stress caused a brake of conditioned reflex activity, immobilization ofanimals, weakening of attention to the conditional stimulus. On a background intranasal application DA (0.15 mgs/of kg) the effect of stress on voice irritation was eliminated, not rendering brake influence on OCR and motor activity. DA via oppressing the reactions of alarm and fear strengthened the focused attention that assisted the improvement of integrative function in the concrete situation of realization of OCR.
authors.forename: Zh O
authors.initials: ZhO
authors.lastname: Kruchenko
authors.forename: N O
authors.initials: NO
authors.lastname: Pil'kevych
mesh_terms: D000161:Acoustic Stimulation; D000281:Administration, Intranasal; D000818:Animals; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D003216:Conditioning, Operant / Q000187:drug effects* / Q000502:physiology; D004298:Dopamine / Q000494:pharmacology*; D005239:Fear / Q000187:drug effects*; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D013315:Stress, Psychological / Q000503:physiopathology
chemical_list: D004298:Dopamine