title: Recent advances in clinical practice challenges and opportunities in the management of obesity.
abstract: Despite advances in understanding the roles of adiposity, food intake, GI and adipocyte-related hormones, inflammatory mediators, the gut-brain axis and the hypothalamic nervous system in the pathophysiology of obesity, the effects of different therapeutic interventions on those pathophysiological mechanisms are controversial. There are still no low-cost, safe, effective treatments for obesity and its complications. Currently, bariatric surgical approaches targeting the GI tract are more effective than non-surgical approaches in inducing weight reduction and resolving obesity-related comorbidities. However, current guidelines emphasise non-surgical approaches through lifestyle modification and medications to achieve slow weight loss, which is not usually sustained and may be associated with medication-related side effects. This review analyses current central, peripheral or hormonal targets to treat obesity and addresses challenges and opportunities to develop novel approaches for obesity.
authors.affiliation: Division of Gastroenterology and Hepatology, Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), , Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
authors.forename: Andres
authors.initials: A
authors.lastname: Acosta
authors.forename: Barham K
authors.initials: BK
authors.lastname: Abu Dayyeh
authors.forename: John D
authors.initials: JD
authors.lastname: Port
authors.forename: Michael
authors.initials: M
authors.lastname: Camilleri
mesh_terms: D050110:Bariatric Surgery / Q000379:methods; D002490:Central Nervous System / Q000503:physiopathology; D006801:Humans; D054795:Incretins / Q000502:physiology; D064307:Microbiota / Q000502:physiology; D009765:Obesity / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D061217:Weight Reduction Programs
chemical_list: D054795:Incretins
keywords: BRAIN/GUT INTERACTION; GASTROINTESTINAL HORMONES; OBESITY