title: Synthesis of novel indenoquinoxaline derivatives as potent α-glucosidase inhibitors.
abstract: A series of new N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazide derivatives (3a-3p) were synthesized and evaluated for their α-glucosidase inhibitory activity. The synthesized compounds 3d, 3f, 3g, 3k, 3n, 3p and 4 showed significant α-glucosidase inhibitory activity as compared to acrabose, a standard drug used to treat type II diabetes. Structures of the synthesized compounds were determined by using FT-IR, (1)H NMR, (13)C NMR, mass spectrometry and elemental analysis techniques.
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
authors.forename: Madiha Sahar
authors.initials: MS
authors.lastname: Khan
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan. Electronic address: mamunawar.chem@pu.edu.pk.
authors.forename: Munawar Ali
authors.initials: MA
authors.lastname: Munawar
authors.affiliation: Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ashraf
authors.affiliation: Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
authors.forename: Umber
authors.initials: U
authors.lastname: Alam
authors.affiliation: Department of Chemistry, University of Winnipeg, 515 Portage Avenue, Winnipeg MB R3B 2E9, Canada.
authors.forename: Athar
authors.initials: A
authors.lastname: Ata
authors.affiliation: Centre of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, PO Box 80203, Jeddah 21589, Saudi Arabia.
authors.forename: Abdullah Mohamed
authors.initials: AM
authors.lastname: Asiri
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan.
authors.forename: Samina
authors.initials: S
authors.lastname: Kousar
authors.affiliation: Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan; Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
authors.forename: Misbahul Ain
authors.initials: MA
authors.lastname: Khan
mesh_terms: D020909:Acarbose / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007093:Imidazoles / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D007093:Imidazoles; C490207:oxaline; D020909:Acarbose
keywords: 1,2-Di(11H-indeno[2,1-b]quioxalin-11-ylidene)hydrazine; 11H-Indeno[1,2-b]quinoxalin-11-one; N-(11H-Indeno[1,2-b]quinoxalin-11-ylidene)benzohydrazides; α-Glucosidase inhibitors