title: Shared mechanisms in stemness and carcinogenesis: lessons from oncogenic viruses.
abstract: A rise in technologies for epigenetic reprogramming of cells to pluripotency, highlights the potential of understanding and manipulating cellular plasticity in unprecedented ways. Increasing evidence points to shared mechanisms between cellular reprogramming and the carcinogenic process, with the emerging possibility to harness these parallels in future therapeutics. In this review, we present a synopsis of recent work from oncogenic viruses which contributes to this body of knowledge, establishing a nexus between infection, cancer, and stemness.
authors.affiliation: Department of Biological Sciences, University of Cyprus Nicosia, Cyprus.
authors.forename: Demetris
authors.initials: D
authors.lastname: Iacovides
authors.affiliation: Department of Biological Sciences, University of Cyprus Nicosia, Cyprus.
authors.forename: Stella
authors.initials: S
authors.lastname: Michael
authors.affiliation: Department of Biological Sciences, University of Cyprus Nicosia, Cyprus.
authors.forename: Charis
authors.initials: C
authors.lastname: Achilleos
authors.affiliation: Department of Biological Sciences, University of Cyprus Nicosia, Cyprus.
authors.forename: Katerina
authors.initials: K
authors.lastname: Strati
mesh_terms: D000818:Animals; D063646:Carcinogenesis; D044127:Epigenesis, Genetic; D005786:Gene Expression Regulation; D006801:Humans; D009858:Oncogenic Viruses / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000502:physiology*
keywords: EBV; HBV; HCV; HPV; KSHV; cancer; reprogramming; stemness