title: TNF-α 308 G/A polymorphism and cervical intraepithelial neoplasia.
abstract: OBJECTIVE
  The purpose of the present study was the analysis of the relationship between tumor necrosis factor-α (TNF-α) -308 G/A and cervical intraepithelial neoplasia (CIN).
  
  
  METHODS
  A prospective case-control study was performed, enrolling 78 cases of cervical intraepithelial neoplasia and 107 controls. Every patient had a complete gynecological examination with cervical sampling and colposcopy and TNF-α 308 G/A genotyping.
  
  
  RESULTS
  The homozygous AA genotype was extremely rare in the study group. The GG genotype was the one most frequently encountered in all classes of cervical intraepithelial neoplasia (CIN) and controls. No statistical differences were found in global comparison between cases and controls [odds ratio (OR)=3, p=0.09], nor between well-documented cases of more evolved high-grade squamous cervical intraepithelial lesion versus controls (OR=1.2, p=0.68). However, the results were significant for invasive carcinoma (OR=10.8261, 95% confidence interval=1.0748-109.0511, p=0.0433).
  
  
  CONCLUSIONS
  The presence of an A allele at -308 TNF-α represents a risk for invasive carcinoma.
authors.affiliation: First Clinic of Obstetrics and Gynecology, County Emergency Hospital, Clinicilor 3-5, 400006 Cluj Napoca, Romania. cristina.rotar@umfcluj.ro.
authors.forename: Ioana Cristina
authors.initials: IC
authors.lastname: Rotar
authors.forename: Daniel
authors.initials: D
authors.lastname: Muresan
authors.forename: Popp
authors.initials: P
authors.lastname: Radu
authors.forename: Felicia
authors.initials: F
authors.lastname: Petrisor
authors.forename: Silvana
authors.initials: S
authors.lastname: Apostol
authors.forename: Tanc
authors.initials: T
authors.lastname: Mariana
authors.forename: Cristina
authors.initials: C
authors.lastname: Butuza
authors.forename: Florin
authors.initials: F
authors.lastname: Stamatian
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D003127:Colposcopy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D011446:Prospective Studies; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: TNF-α; cervical intraepithelial neoplasia; genetic polymorphism