title: Mycosynthesis: antibacterial, antioxidant and antiproliferative activities of silver nanoparticles synthesized from Inonotus obliquus (Chaga mushroom) extract.
abstract: In the present study, silver nanoparticles (AgNPs) were rapidly synthesized from silver nitrate solution at room temperature using Inonotus obliquus extract. The mycogenic synthesized AgNPs were characterized by UV-Visible absorption spectroscopy, Fourier transform infrared (FTIR), scanning electron microscopy (SEM) with energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM) and atomic force microscopy (AFM). SEM revealed mostly spherical nanoparticles ranging from 14.7 to 35.2nm in size. All AgNPs concentrations showed good ABT radical scavenging activity. Further, AgNPs showed effective antibacterial activity against both gram negative and gram positive bacteria and antiproliferative activity toward A549 human lung cancer (CCL-185) and MCF-7 human breast cancer (HTB-22) cell lines. The samples demonstrated considerably high antibacterial, and antiproliferative activities against bacterial strains and cell lines.
authors.affiliation: Department of Physiology, College of Oriental Medicine, Dongguk University, Gyeongju, South Korea.
authors.forename: P C
authors.initials: PC
authors.lastname: Nagajyothi
authors.affiliation: Department of Life Chemistry, Catholic University of Daegu, Gyeongsan 712-702, South Korea.
authors.forename: T V M
authors.initials: TV
authors.lastname: Sreekanth
authors.affiliation: Department of Nanomaterial Chemistry, Dongguk University, Gyeongju, South Korea.
authors.forename: Jae-il
authors.initials: JI
authors.lastname: Lee
authors.affiliation: Department of Nanomaterial Chemistry, Dongguk University, Gyeongju, South Korea. Electronic address: kdlee@dongguk.ac.kr.
authors.forename: Kap Duk
authors.initials: KD
authors.lastname: Lee
mesh_terms: D000363:Agaricales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D052160:Benzothiazoles / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D052160:Benzothiazoles; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; D012834:Silver
keywords: AgNPs; Antibacterial; Antiproliferative; Inonotus obliquus; Mycogenicsynthesis; TEM