title: The challenge of pancreatic cancer therapy and novel treatment strategy using engineered mesenchymal stem cells.
abstract: Mesenchymal stem cells (MSCs) have attracted significant attention in cancer research as a result of their accessibility, tumor-oriented homing capacity, and the feasibility of auto-transplantation. This review provides a comprehensive overview of current challenges in pancreatic cancer therapy, and we propose a novel strategy for using MSCs as means of delivering anticancer genes to the site of pancreas. We aim to provide a practical platform for the development of MSC-based therapy for pancreatic cancer.
authors.affiliation: Department of Surgery, University of British Columbia, Vancouver BC, Canada.
authors.forename: M R
authors.identifier: 0000000341727348
authors.initials: MR
authors.lastname: Moniri
authors.affiliation: 1] Department of Surgery, University of British Columbia, Vancouver BC, Canada [2] Hubei Key Laboratory of Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.
authors.forename: L-J
authors.initials: LJ
authors.lastname: Dai
authors.affiliation: Department of Surgery, University of British Columbia, Vancouver BC, Canada.
authors.forename: G L
authors.initials: GL
authors.lastname: Warnock
mesh_terms: D000818:Animals; D058750:Epithelial-Mesenchymal Transition; D015316:Genetic Therapy; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D015398:Signal Transduction; D060449:Wnt Signaling Pathway