title: p-Stat3 and bcr/abl gene expression in chronic myeloid leukemia and their relation to imatinib therapy.
abstract: Flowcytometry analysis was carried out to evaluate the expression of the p-Stat3 in 50 CML patients and 20 age-matched healthy controls. p-Stat3 expression was increased in advanced stages of CML. Imatinib treatment was found to suppress the expression of p-Stat3 in bone marrow cells. The level of p-Stat3 was found to be higher in resistant cases than in responsive cases, which suggest the beneficial use of p-Stat3 as an indicator to follow the clinical course and the treatment response.
authors.affiliation: Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Egypt. Electronic address: douaa_sayed@hotmail.com.
authors.forename: Douaa
authors.initials: D
authors.lastname: Sayed
authors.affiliation: Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Egypt.
authors.forename: Hosny
authors.initials: H
authors.lastname: Badrawy
authors.affiliation: Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Egypt.
authors.forename: Noha
authors.initials: N
authors.lastname: Gaber
authors.affiliation: Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Egypt.
authors.forename: Muhammed R
authors.initials: MR
authors.lastname: Khalaf
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D016022:Case-Control Studies; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010766:Phosphorylation; D010879:Piperazines / Q000627:therapeutic use*; D011494:Protein Kinases / Q000378:metabolism*; D011743:Pyrimidines / Q000627:therapeutic use*; D050796:STAT3 Transcription Factor / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D000068877:Imatinib Mesylate; D011494:Protein Kinases; D016044:Fusion Proteins, bcr-abl
keywords: Chronic myeloid leukemia; Imatinib; Stat3; bcr-abl