title: Auditory neuropathy: a challenge for diagnosis and treatment.
abstract: In current terminology, auditory neuropathy spectrum disorder (ANSD) is a disease involving the disruption of the temporal coding of acoustic signals in auditory nerve fibres, resulting in the impairment of auditory perceptions that rely on temporal cues. There is debate about almost every aspect of the disorder, including aetiology, lesion sites, and the terminology used to describe it. ANSD is a heterogeneous disease despite similar audiological findings. The absence of an auditory brainstem response (ABR) and the presence of otoacoustic emissions (OAE) suggest an ANSD profile. However, to determine the exact anatomical site of the disorder, more in-depth audiological and electrophysiological tests must be combined with imaging, genetics and neurological examinations. Greater diagnostic specificity is therefore needed to provide these patients with more adequate treatment.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, and Communication Disorders, University of Antwerp, Antwerp, Belgium. frank.declau@telenet.be
authors.forename: F
authors.initials: F
authors.lastname: Declau
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, and Communication Disorders, University of Antwerp, Antwerp, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Boudewyns
authors.affiliation: Department of Medical Genetics, University of Antwerp, Antwerp, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Van den Ende
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, and Communication Disorders, University of Antwerp, Antwerp, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: van de Heyning
mesh_terms: D001309:Auditory Threshold / Q000502:physiology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006310:Hearing Aids; D006313:Hearing Loss, Central / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D006320:Hearing Tests; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015997:Neonatal Screening; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology; D012307:Risk Factors