title: Spatial frequency analysis of high-density lipoprotein and iron-oxide nanoparticle transmission electron microscope image structure for pattern recognition in heterogeneous fields.
abstract: The optical spatial frequencies of tumor interstitial fluid (TIF) are investigated. As a concentrated colloidal suspension of interacting native nanoparticles, the TIF can develop internal ordering under shear stress that may hinder delivery of antitumor agents within tumors. A systematic method is presented to characterize the TIF nanometer-scale microstructure in a model suspension of superparamagnetic iron-oxide nanoparticles and reconstituted high-density lipoprotein by Fourier spatial frequency (FSF) analysis so as to differentiate between jammed and fluid structural features in static transmission electron microscope images. The FSF method addresses one obstacle faced in achieving quantitative dosimetry to neoplastic tissue, that of detecting these nanoscale barriers to transport, such as would occur in the extravascular space immediately surrounding target cells.
authors.affiliation: City College of New York, Mechanical Engineering Department, New York, New York 10031dThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755.
authors.forename: Stewart
authors.initials: S
authors.lastname: Russell
authors.affiliation: City College of New York, Institute for Ultrafast Spectroscopy and Lasers, Physics Department, New York, New York 10031.
authors.forename: Thien An
authors.initials: TA
authors.lastname: Nguyen
authors.affiliation: City College of New York, Mechanical Engineering Department, New York, New York 10031.
authors.forename: Clyde Rey
authors.initials: CR
authors.lastname: Torres
authors.affiliation: City College of New York, Institute for Ultrafast Spectroscopy and Lasers, Physics Department, New York, New York 10031.
authors.forename: Stephen
authors.initials: S
authors.lastname: Bhagroo
authors.affiliation: City College of New York, Chemistry Department, New York, New York 10031.
authors.forename: Milo J
authors.initials: MJ
authors.lastname: Russell
authors.affiliation: City College of New York, Institute for Ultrafast Spectroscopy and Lasers, Physics Department, New York, New York 10031.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Alfano
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D003102:Colloids / Q000737:chemistry; D004337:Drug Carriers; D005290:Ferric Compounds / Q000737:chemistry*; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008075:Lipoproteins, HDL / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy; D055095:Optics and Photonics; D010363:Pattern Recognition, Automated; D033081:Shear Strength; D013314:Stress, Mechanical
chemical_list: D000970:Antineoplastic Agents; D003102:Colloids; D004337:Drug Carriers; D005290:Ferric Compounds; D008075:Lipoproteins, HDL; C000499:ferric oxide