title: Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives.
abstract: A series of 17 selected natural and semisynthetic 1,4-naphthoquinones were synthesized, and their growth inhibitory activity was evaluated in vitro. The compounds were tested on six human cancer cell lines using the MTT colorimetric assay. The data revealed that of the chemicals under study only lapachol, its acetate and 3-geranyllawsone displayed the highest activity, recording mean IC50 values ranging from 15 to 22 μM.
authors.affiliation: Dipartimento di Farmacia, Università 'G. D'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy.
authors.forename: Serena
authors.initials: S
authors.lastname: Fiorito
authors.affiliation: Dipartimento di Farmacia, Università 'G. D'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy. Electronic address: fepifano@unich.it.
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.affiliation: Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles, 1050 Brussels, Belgium.
authors.forename: Céline
authors.initials: C
authors.lastname: Bruyère
authors.affiliation: Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles, 1050 Brussels, Belgium.
authors.forename: Véronique
authors.initials: V
authors.lastname: Mathieu
authors.affiliation: Laboratoire de Cancérologie et de Toxicologie Expérimentale, Faculté de Pharmacie, Université Libre de Bruxelles, 1050 Brussels, Belgium.
authors.forename: Robert
authors.initials: R
authors.lastname: Kiss
authors.affiliation: Dipartimento di Farmacia, Università 'G. D'Annunzio' Chieti-Pescara, Via dei Vestini 31, 66100 Chieti Scalo (CH), Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Genovese
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003124:Colorimetry / Q000379:methods; D006131:Growth Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D009285:Naphthoquinones / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006131:Growth Inhibitors; D009285:Naphthoquinones; D010936:Plant Extracts; C008252:lapachol
keywords: 1,4-Naphthoquinones; Cancer; In vitro growth inhibition; Lapachol