title: [Spontaneous regression of breast cancer after biopsy. About two cases].
abstract: We report two cases of spontaneous regression of breast cancer occurred in our institution. It was about a 34- and an 82-year-old patient. The examination revealed a palpable nodule. In both cases, biopsy revealed a negative immunohistochemical staining for estrogen and progesterone receptors, and HER-2 negative. Histological analysis of the surgical specimen found fibrous tissue rearrangement without carcinoma. In the first case, a sarcoidosis was diagnosed at the same time, the mediastinal nodes mimicked a metastatic cancer. These cases illustrate a rare phenomenon. The main hypothesis is a carcinoma- directed immune response triggered by the biopsy.
authors.affiliation: Centre Léon-Bérard, département de chirurgie oncologique, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Maillet
authors.affiliation: Centre Léon-Bérard, département de chirurgie oncologique, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France.
authors.forename: N
authors.initials: N
authors.lastname: Chopin
authors.affiliation: Centre Léon-Bérard, département d'anatomopathologie, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France.
authors.forename: I
authors.initials: I
authors.lastname: Treilleux
authors.affiliation: Centre Léon-Bérard, département d'oncologie médicale, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France.
authors.forename: T
authors.initials: T
authors.lastname: Bachelot
authors.affiliation: Centre Léon-Bérard, département d'oncologie médicale, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France.
authors.forename: O
authors.initials: O
authors.lastname: Tredan
authors.affiliation: Centre Léon-Bérard, département de chirurgie oncologique, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Faure
authors.affiliation: Université de Lyon, 69000 Lyon, France; Université Lyon-1, ISPB, Lyon, 69622, 69000 Lyon, France; Inserm U1052, centre de recherche en cancérologie de Lyon, 69000 Lyon, France; CNRS UMR5286, centre de recherche en cancérologie de Lyon, 69000 Lyon, France; Centre Léon Bérard, plateforme d'innovation en immunomonitoring et immunothérapie, 69008 Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Caux
authors.affiliation: Centre Léon-Bérard, département de chirurgie oncologique, université de Lyon 1, 28, rue Laennec, 69008 Lyon, France. Electronic address: frederic.beurrier@lyon.unicancer.fr.
authors.forename: F
authors.initials: F
authors.lastname: Beurrier
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D001706:Biopsy; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008327:Mammography; D009365:Neoplasm Regression, Spontaneous; D012507:Sarcoidosis / Q000473:pathology
keywords: Breast cancer; Cancer du sein; Régression spontanée; Sarcoidosis; Sarcoïdose; Spontaneous regression