title: Metal-free cascade radical cyclization of 1,6-enynes with aldehydes.
abstract: A new and efficient metal-free cascade cyclization of 1,6-enynes with aldehydes is developed for the synthesis of tricyclic fluorene derivatives. The reaction involves a radical process and one C(sp(2))-C(sp(2)) and two C(sp(2))-C(sp(3)) bonds are formed simultaneously in one pot by using PivOH and TBHP.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, and State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, P.R. China. liangym@lzu.edu.cn.
authors.forename: Jian-Yi
authors.initials: JY
authors.lastname: Luo
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Hua
authors.forename: Zi-Sheng
authors.initials: ZS
authors.lastname: Chen
authors.forename: Zhao-Zhao
authors.initials: ZZ
authors.lastname: Zhou
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Yang
authors.forename: Ping-Xin
authors.initials: PX
authors.lastname: Zhou
authors.forename: Yu-Tao
authors.initials: YT
authors.lastname: He
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D003500:Cyclization; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000475:Alkenes; D000480:Alkynes; D005449:Fluorenes; D005609:Free Radicals