title: Executive functioning complaints and escitalopram treatment response in late-life depression.
abstract: OBJECTIVE
  Executive dysfunction may play a key role in the pathophysiology of late-life depression. Executive dysfunction can be assessed with cognitive tests and subjective report of difficulties with executive skills. The present study investigated the association between subjective report of executive functioning complaints and time to escitalopram treatment response in older adults with major depressive disorder (MDD).
  
  
  METHODS
  100 older adults with MDD (58 with executive functioning complaints and 42 without executive functioning complaints) completed a 12-week trial of escitalopram. Treatment response over 12 weeks, as measured by repeated Hamilton Depression Rating Scale scores, was compared for adults with and without executive complaints using mixed-effects modeling.
  
  
  RESULTS
  Mixed effects analysis revealed a significant group × time interaction, F(1, 523.34) = 6.00, p = 0.01. Depressed older adults who reported executive functioning complaints at baseline demonstrated a slower response to escitalopram treatment than those without executive functioning complaints.
  
  
  CONCLUSIONS
  Self-report of executive functioning difficulties may be a useful prognostic indicator for subsequent speed of response to antidepressant medication.
authors.affiliation: Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY. Electronic address: kem9085@nyp.org.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Manning
authors.affiliation: Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY.
authors.forename: George S
authors.initials: GS
authors.lastname: Alexopoulos
authors.affiliation: Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY.
authors.forename: Samprit
authors.initials: S
authors.lastname: Banerjee
authors.affiliation: Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY.
authors.forename: Sarah Shizuko
authors.initials: SS
authors.lastname: Morimoto
authors.affiliation: Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY.
authors.forename: Joanna K
authors.initials: JK
authors.lastname: Seirup
authors.affiliation: Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY.
authors.forename: Sibel A
authors.initials: SA
authors.lastname: Klimstra
authors.affiliation: Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY.
authors.forename: Genevieve
authors.initials: G
authors.lastname: Yuen
authors.affiliation: Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY.
authors.forename: Theodora
authors.initials: T
authors.lastname: Kanellopoulos
authors.affiliation: Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY.
authors.forename: Faith
authors.initials: F
authors.lastname: Gunning-Dixon
mesh_terms: D000328:Adult; D000368:Aged; D000554:Ambulatory Care Facilities; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage; D015283:Citalopram / Q000008:administration & dosage*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D016903:Drug Monitoring / Q000379:methods; D056344:Executive Function / Q000187:drug effects*; D005260:Female; D006801:Humans; D000067562:Late Onset Disorders; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011569:Psychiatric Status Rating Scales; D057566:Self Report; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D015283:Citalopram
keywords: Depression; aging; executive functioning