title: Human papilloma virus--role in precancerous and cancerous oral lesions of tobacco chewers.
abstract: Human papilloma viruses (HPV), members of the papillomaviridae family, infects squamous epithelial cells of cevix, lower genitalia, and oral cavity. The association of HPV with oropharyngeal carcinogenesis is well documented.The incidence of oral cancer ranks second in Karachi South in both genders according to World Health Organization (WHO) statistics. This is attributed to the popularity of chewable tobacco products among the general population. Studies on Gutka-eaters in a set population of Karachi showed high frequency of HPV (17%) and high prevalence of HPV in squamous cell carcinoma in Pakistani patients (68%). The exposure of oral mucosa to chewable tobacco causes abrasions making it susceptible to HPV. This review strives to summarise the role of HPV in chewable tobacco-related precancerous and cancerous lesions. The literature of about a decade was retrieved from Google and pubMed with the under mentioned key words. It was found that the use of chewable tobacco products, especially Gutka, may increase the risk of oral squamous cell carcinoma (OSCC).
authors.affiliation: Biochemistry Department, Ziauddin Medical College, Ziauddin University, Karachi. zile_rubab@hotmail.com
authors.lastname: Zil-A-Rubab
authors.affiliation: Biochemistry Department, Ziauddin Medical College, Ziauddin University, Karachi.
authors.forename: Saeeda
authors.initials: S
authors.lastname: Baig
authors.affiliation: Ziauddin Medical College, Ziauddin University, Karachi.
authors.forename: Ayesha
authors.initials: A
authors.lastname: Siddiqui
authors.affiliation: Ziauddin Medical College, Ziauddin University, Karachi.
authors.forename: Amena
authors.initials: A
authors.lastname: Nayeem
authors.affiliation: Ziauddin Medical College, Ziauddin University, Karachi.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Salman
authors.affiliation: Ziauddin Medical College, Ziauddin University, Karachi.
authors.forename: Moiz Ahmed
authors.initials: MA
authors.lastname: Qidwai
authors.affiliation: Ziauddin Medical College, Ziauddin University, Karachi.
authors.forename: Raiya
authors.initials: R
authors.lastname: Mallick
authors.affiliation: Ziauddin Medical College, Ziauddin University, Karachi.
authors.forename: Samrah
authors.initials: S
authors.lastname: Qidwai
mesh_terms: D052685:Alphapapillomavirus / Q000302:isolation & purification; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D006258:Head and Neck Neoplasms / Q000821:virology*; D006801:Humans; D009061:Mouth Mucosa / Q000821:virology; D009062:Mouth Neoplasms / Q000821:virology*; D009361:Neoplasm Invasiveness; D030361:Papillomavirus Infections / Q000150:complications*; D011230:Precancerous Conditions / Q000821:virology*; D000077195:Squamous Cell Carcinoma of Head and Neck; D064424:Tobacco Use