title: Vigabatrin induced Cell loss in the Cerebellar Cortex of Albino Rats.
abstract: BACKGROUND
  Vigabatrin is used as the drug of choice in resistant epilepsy and infantile spasms. Ataxia, tremors and abnormal gait have been frequently reported following the use of this drug, indicating an involvement of the cerebellum.
  
  
  OBJECTIVE
  The present study was designed to study the histopathological effects of Vigabatrin on the cerebellum of albino rats.
  
  
  METHODS
  Albino Rats were divided into an experimental and a control group. Vigabatrin was administered intra-peritoneally to the experimental group in graded doses for a period of 4 weeks. At the end of the treatment period, rats were sacrificed and brains were dissected out. The cerebellum was separated and fixed. Slides were prepared for histological examination.
  
  
  RESULTS
  Decreased cell counts in the cerebellar cortex secondary to toxic injury were found. Severity increased with increasing doses.
  
  
  CONCLUSIONS
  Vigabatrin may be neurotoxic and should be used with caution, assessing cerebellar function at regular intervals.
authors.affiliation: Assistant Professor, Department of Anatomy, Himalayan Institute of Medical Sciences , Dehradun Uttarakhand, 248140, India .
authors.forename: Deepa
authors.initials: D
authors.lastname: Singh
authors.affiliation: Professor and Head, Department of Anatomy, Himalayan Institute of Medical Sciences , Dehradun Uttarakhand, 248140, India .
authors.forename: Sunder Lal
authors.initials: SL
authors.lastname: Jethani
authors.affiliation: Assistant Professor, Department of Anatomy, Himalayan Institute of Medical Sciences , Dehradun Uttarakhand, 248140, India .
authors.forename: Aksh
authors.initials: A
authors.lastname: Dubey
keywords: Albino rats; Cell loss; Cerebellum; GABA; Vigabatrin