title: BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease.
abstract: Brain-derived neurotrophic factor (BDNF) is a neurotrophin widely expressed in the mammalian brain, regulating neuronal survival and known to influence dopaminergic neurons and cognitive processes. The present study investigated the BDNF Val66Met polymorphism associations with PD risk, and cognitive impairment in PD. A total of 486 study subjects (244 PD and 242 age and sex matched controls) were included in the study. UPDRS score, Hoehn-Yahr staging and the Schwab-England scale were used to assess motor abilities and activity during daily life. The patients were classified into groups with dementia (PDD, n=69) and without it (nPDD, n=166) on the basis of neuropsychological assessment. The most common functional polymorphism in BDNF Val66Met (rs6265, G196A) gene was determined using TaqMan real-time PCR assay. Frequencies of evaluated BDNF alleles and genotypes were similar in PD and the controls. The mean age of disease onset among BDNF Met/Met carriers was later (65.00±6.13) in comparison to Val/Val (57.45±10.68) and Val/Met (56.33±10.91) subjects (p=0.077). The studied BDNF polymorphism was not associated with cognitive status in PD patients. However, patients with Met/Met alleles demonstrated better delayed recall of information than patients with Val/Val alleles. The results of multivariate logistic regression analysis revealed age (p=0.0003) and the disease stage (p=0.002) as independent risk factors predisposing to PD dementia.
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstańców Wlkp 72, 70-111 Szczecin, Poland. Electronic address: monika-bialecka@post.pl.
authors.forename: Monika
authors.initials: M
authors.lastname: Białecka
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstańców Wlkp 72, 70-111 Szczecin, Poland. Electronic address: mkurz@pum.edu.pl.
authors.forename: Mateusz
authors.initials: M
authors.lastname: Kurzawski
authors.affiliation: Department of Neurological-Psychiatric Nursing, Medical University of Gdańsk, Al. Jana Pawła II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawła II 50, 80-462 Gdańsk, Poland. Electronic address: annaroszmann@gmail.com.
authors.forename: Anna
authors.initials: A
authors.lastname: Roszmann
authors.affiliation: Department of Neurological-Psychiatric Nursing, Medical University of Gdańsk, Al. Jana Pawła II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawła II 50, 80-462 Gdańsk, Poland. Electronic address: piotr.amg@wp.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Robowski
authors.affiliation: Department of Neurological-Psychiatric Nursing, Medical University of Gdańsk, Al. Jana Pawła II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawła II 50, 80-462 Gdańsk, Poland. Electronic address: emsitek@gmail.com.
authors.forename: Emilia J
authors.initials: EJ
authors.lastname: Sitek
authors.affiliation: Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-251 Szczecin, Poland. Electronic address: khonczar@pum.edu.pl.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Honczarenko
authors.affiliation: Clinic of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland. Electronic address: monika.mak@gmail.com.
authors.forename: Monika
authors.initials: M
authors.lastname: Mak
authors.affiliation: Department of Neurology, Marie Curie Regional Hospital, Arkońska 4, 71-455 Szczecin, Poland. Electronic address: jaroszki@interia.pl.
authors.forename: Monika
authors.initials: M
authors.lastname: Deptuła-Jarosz
authors.affiliation: Clinic of Neurology, Pomeranian Medical University, Unii Lubelskiej 1, 71-251 Szczecin, Poland. Electronic address: monikagj@op.pl.
authors.forename: Monika
authors.initials: M
authors.lastname: Gołąb-Janowska
authors.affiliation: Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Powstańców Wlkp 72, 70-111 Szczecin, Poland. Electronic address: drozdzik@pum.edu.pl.
authors.forename: Marek
authors.initials: M
authors.lastname: Droździk
authors.affiliation: Department of Neurological-Psychiatric Nursing, Medical University of Gdańsk, Al. Jana Pawła II 50, 80-462, Poland; Department of Neurology, St. Adalbert Hospital, Al. Jana Pawła II 50, 80-462 Gdańsk, Poland. Electronic address: jaroslawek@gumed.edu.pl.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Sławek
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics* / Q000523:psychology; D011110:Polymorphism, Genetic
chemical_list: D019208:Brain-Derived Neurotrophic Factor
keywords: BDNF; Dementia; Genetic polymorphism; Parkinson's disease