title: Implementing the Jadelle implant for women living with HIV in a resource-limited setting: concerns for drug interactions leading to unintended pregnancies.
abstract: An analysis of 570 HIV-infected women in Swaziland using the Jadelle implant showed that age, condom use, the provider who placed the implant, and CD4 cell count had no effect on unintentional pregnancy rates. Antiretroviral regimen at the time of pregnancy, however, correlated with pregnancy outcomes (P < 0.001). None of the women on nevirapine or lopinavir/ritonavir-based regimens (n = 208 and 13, respectively) became pregnant, whereas 15 women on efavirenz (n = 121; 12.4%) became pregnant.
authors.affiliation: aBaylor College of Medicine, Baylor International Pediatric AIDS Initiative, Children's Foundation bDepartment of Pediatrics, Baylor College of Medicine/Texas Children's Hospital cBaylor Bristol-Myers Squibb Children's Clinical Center of Excellence-Swaziland dKingdom of Swaziland Ministry of Health, Sexual and Reproductive Health Unit, Mbabane, Swaziland.
authors.forename: Sarah H
authors.initials: SH
authors.lastname: Perry
authors.forename: Padma
authors.initials: P
authors.lastname: Swamy
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Preidis
authors.forename: Anne
authors.initials: A
authors.lastname: Mwanyumba
authors.forename: Nozipho
authors.initials: N
authors.lastname: Motsa
authors.forename: Hailu N
authors.initials: HN
authors.lastname: Sarero
mesh_terms: D000293:Adolescent; D000328:Adult; D000480:Alkynes; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D048588:Benzoxazines / Q000627:therapeutic use; D003271:Contraceptive Agents, Female / Q000627:therapeutic use*; D003521:Cyclopropanes; D004347:Drug Interactions; D013541:Eswatini; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D061466:Lopinavir / Q000627:therapeutic use; D008875:Middle Aged; D019829:Nevirapine / Q000627:therapeutic use; D011247:Pregnancy; D049168:Pregnancy, Unplanned; D019438:Ritonavir / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000480:Alkynes; D044966:Anti-Retroviral Agents; D048588:Benzoxazines; D003271:Contraceptive Agents, Female; D003521:Cyclopropanes; D061466:Lopinavir; D019829:Nevirapine; C098320:efavirenz; D019438:Ritonavir