title: [Safety and feasibility of gastrectomy after neoadjuvant chemotherapy for gastric cancer].
abstract: OBJECTIVE
  The aim of this study was to evaluate the safety and feasibility of gastrectomy after neoadjuvant chemotherapy in patients with gastric cancer.
  
  
  METHODS
  Forty-five patients received neoadjuvant chemotherapy and curative gastrectomy between December 2002 and May 2011. Surgical complications were evaluated according to the Clavien- Dindo classification.
  
  
  RESULTS
  The median age of the patients was 63 years. Twenty-three patients received a PTX and CDDP regimen, 20 received an S-1 and CDDP regimen, 1 received an S-1 regimen, and 1 received an CPT-11 and CDDP regimen as neoadjuvant chemotherapy. Distal gastrectomy was performed in 6 patients, and total gastrectomy was performed in 39 patients. The median operation time was 268 minutes, and the median blood loss was 249.5 mL. Complications more severe than grade 2 were observed in 10 patients: anatomic bleeding( grade 3a) was observed in 2 patients; abdominal abscess( grade 2), in 1 patient; and pancreatic fistula( grade 2), in 7 patients. No surgical mortality was observed.
  
  
  CONCLUSIONS
  The results of our study suggest that gastrectomy after neoadjuvant chemotherapy for the treatment of patients with gastric cancer is safe and feasible.
authors.affiliation: Dept. of Gastrointestinal Surgery, Kanagawa Cancer Center.
authors.forename: Toru
authors.initials: T
authors.lastname: Aoyama
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Hayashi
authors.forename: Hirohito
authors.initials: H
authors.lastname: Fujikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogata
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Cho
authors.forename: Hiroo
authors.initials: H
authors.lastname: Wada
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kitani
authors.forename: Norio
authors.initials: N
authors.lastname: Yukawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Oshima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Ozawa
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.forename: Takaki
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011183:Postoperative Complications; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000601:surgery*; D016896:Treatment Outcome