title: The interaction between DAP1 and autophagy in the context of human carcinogenesis.
abstract: Autophagy is an evolutionarily-conserved catabolic process which furthers cell survival, especially in times of nutritional stress. Whilst being by itself a pro-survival mechanism, it has many areas of overlap with apoptosis. Autophagic cell death is recognised as a subset of programmed cell death, with features more typical of autophagy rather than classical apoptosis. The mechanisms preventing autophagy from unravelling into autophagic cell death are still the subject of much controversy. We discuss the current understanding of these mechanisms, including recent research regarding the role of death-associated protein-1 in autophagy and apoptosis.
authors.affiliation: London Breast Institute, The Princess Grace Hospital, 45 Nottingham Place, London W1U 5NY, U.K. kefahmokbel@hotmail.com.
authors.forename: Umar
authors.initials: U
authors.lastname: Wazir
authors.forename: Zubair S
authors.initials: ZS
authors.lastname: Khanzada
authors.forename: Wen G
authors.initials: WG
authors.lastname: Jiang
authors.forename: Anup K
authors.initials: AK
authors.lastname: Sharma
authors.forename: Abdul
authors.initials: A
authors.lastname: Kasem
authors.forename: Kefah
authors.initials: K
authors.lastname: Mokbel
mesh_terms: D051017:Apoptosis Regulatory Proteins / Q000378:metabolism*; D001343:Autophagy; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology*; D006801:Humans
chemical_list: D051017:Apoptosis Regulatory Proteins; C091572:DAP protein, human
keywords: Autophagy; apoptosis; breast cancer; carcinogenesis; death-associated protein 1; macroautophagy; oncogenesis; review