title: Efficacy of combination treatment with cyclosporin A and corticosteroids for acute interstitial pneumonitis associated with dermatomyositis.
abstract: Abstract Interstitial pneumonitis (IP) associated with polymyositis and dermatomyositis (PM/DM) is a serious complication that affects prognosis. We therefore undertook a retrospective multicenter study to examine the efficacy of a combination treatment with cyclosporin A (CsA) and corticosteroids. Fifty-three IP patients with PM/DM (9 PM, 44 DM) were analyzed. Thirty-two patients treated with CsA plus corticosteroids (9 PM, 23 DM) were included in the study. Four parameters, i.e., subjective symptoms, ausculatory sound, chest radiographs, and respiratory index, were serially evaluated. A general evaluation was performed 4 weeks after the start of the combination treatment. All patients with PM and chronic IP with DM, and 52% of those with acute IP with DM were graded as better than "partially effective" in the general evaluation. In contrast, all patients graded as "progressive" in the general evaluation had acute IP with DM. It is of note that in acute IP with DM, the survival rate of the group primarily treated with CsA and corticosteroids from the early stage of their disease was significantly higher than that of the group initially treated with corticosteroids alone (P = 0.049). In conclusion, a combination treatment of CsA and corticosteroids from the early stage of disease may be advantageous for patients with IP with PM/DM, especially acute IP with DM.
authors.affiliation: Department of Bioregulatory Medicine and Rheumatology, Graduate School, Tokyo Medical and Dental University , 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519 , Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Nagasaka
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Harigai
authors.forename: Mutsuto
authors.initials: M
authors.lastname: Tateishi
authors.forename: Masako
authors.initials: M
authors.lastname: Hara
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: Takao
authors.initials: T
authors.lastname: Koike
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Miyasaka