title: Immunohistochemical Expression of PCNA in Epithelial Linings of Selected Odontogenic Lesions.
abstract: OBJECTIVE
  Though odontogenic lesions have in common origin from the primitive odontogenic epithelium , there is a diversity in their initiation behavior and growth. The aggressive nature of odontogenic keratocyst similar to ameloblastoma in comparision with the other common odontogenic (dentigerous and radicular) cyst could be due to possible differences in their epithelial linings. PCNA (Proliferating cell nuclear antigen) is a cell cycle related antigen, used in the study of cell kinetics of these epithelial linings, to corelate the biological behaviour among these common odontogenic lesions.
  
  
  OBJECTIVE
  This paper has intended to study the cell kinetics of 4 selected odontogenic lesions (dentigerous cyst, radicular cyst,odontogenic keratocyst and ameloblastoma) to demonstrate differences in their epithelial linings.
  
  
  METHODS
  Sixty samples of paraffin embedded tissue specimens (archival tissues) were included (15 radicularcysts, 15 odontogenic keratocysts; 15 dentigerous cysts and15 Ameloblastoma.
  
  
  RESULTS
  Among cyst OKC had higher values than DC and RC. When staining results of all the cyst were compared individually with ameloblastoma ,the staining results of OKC was similar to ameloblastoma ,and ameloblastoma presented higher values than OKC (p=0.000).
  
  
  CONCLUSIONS
  The results of this study show 1) Though OKC and DC are developmental in origin and radicular cyst is inflammatory, OKC has intrinsic growth potential among these cyst 2). Ameloblastoma has similar proliferative potential as OKC and hence it has been reinforced as KCOT(Keratocystic odontogenic tumour) in the recent classification.
authors.affiliation: Senior Lecturer, Department of Oral Pathology, Sri Sai College of Dental Sugery , Vikarabad, India .
authors.forename: Tanveer
authors.initials: T
authors.lastname: Shahela
authors.affiliation: Senior Lecturer, Department of Oral Pathology, Chettinad Dental College , Chennai, India .
authors.forename: Syeda
authors.initials: S
authors.lastname: Aesha
authors.affiliation: Professor and Head of Department, Department of Oral Pathology, Ragas Dental College and Hospital , Chennai, India .
authors.forename: Kannan
authors.initials: K
authors.lastname: Ranganathan
authors.affiliation: Assistant Professor, Department of Oral Pathology, Ragas Dental College and Hospital , Chennai, India .
authors.forename: Rooban
authors.initials: R
authors.lastname: T
authors.affiliation: Professor, Department of Oral Pathology, Ragas Dental College and Hospital , Chennai, India .
authors.forename: Uma Devi
authors.initials: UD
authors.lastname: Roa K
authors.affiliation: Professor, Department of Oral Pathology, Ragas Dental College and Hospital , Chennai, India .
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Joshua
authors.affiliation: Professor and Head of Department, Department of Oral Pathology, Sri Sai College of Dental Surgery , Vikarabad, India .
authors.forename: Afroz Syed
authors.initials: AS
authors.lastname: Ahmed
authors.affiliation: Senior Lecturer, Department of Oral Pathology, Sri Sai College of Dental Surgery , Vikarabad, India .
authors.forename: Harika
authors.initials: H
authors.lastname: Chittamsetty
keywords: Cell kinetics; Immunohistochemistry; Odontogenic tumours; PCNA