title: Does omethoate have the potential to cause insulin resistance?
abstract: Persistent organic pollutant exposure is strongly associated with the development of diabetes. The development of diabetes or alteration in blood glucose levels is associated with insulin resistance that precedes diabetes for many years. Omethoate is a commonly used insecticide in most developing countries. The present study was designed to elucidate the potent role of omethoate in developing insulin resistance in rats. Male Wistar rats were exposed to omethoate at the concentration of 1.5mg/kg body weight (1/40 LD₅₀), 3 mg/kg body weight (1/20 LD₅₀) and 6 mg/kg body weight (1/10 LD₅₀) through gastric injection for 60 days; control group rats received PBS through gastric injection. The results showed that the levels of MDA, TNF-α and IL-6 were increased and the activities of SOD and GSH-Px were decreased in the right thigh muscles of rats exposed to omethoate. However, JNK, p38 MAPK and NF-κB in right thigh muscles of rats exposed to omethoate were activated. This study suggested that omethoate had a potential to cause insulin resistance.
authors.affiliation: Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Yunjian
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Ren
authors.affiliation: Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Wei
authors.affiliation: Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Zhixing
authors.initials: Z
authors.lastname: Ren
authors.affiliation: Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Jingmao
authors.initials: J
authors.lastname: Lv
authors.affiliation: Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Fenglan
authors.initials: F
authors.lastname: Niu
authors.affiliation: Department of Toxicology, School of Public Health, Jilin University, Changchun 130021, China. Electronic address: rensp@jlu.edu.cn.
authors.forename: Shuping
authors.initials: S
authors.lastname: Ren
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004117:Dimethoate / Q000031:analogs & derivatives* / Q000633:toxicity; D005979:Glutathione Peroxidase / Q000378:metabolism; D007306:Insecticides / Q000633:toxicity*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007306:Insecticides; D007328:Insulin; D015850:Interleukin-6; D016328:NF-kappa B; D014409:Tumor Necrosis Factor-alpha; C002302:dimethoxon; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D048031:JNK Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases; D004117:Dimethoate
keywords: IL-6; Insulin resistance; JNK; NF-κB; Omethoate; TNF-α