title: Genomic lens on neuroglobin transcription.
abstract: Neuroglobin is a brain globin with neuroprotective effects against ischemia and related pathological processes, acting as O2 sensor and antiapoptotic pathway transducer. Here, we survey data on neuroanatomical coexpression of transcription factors, epigenetic signature and predictive transcription factor binding sites at the neuroglobin gene locus to find hints of pathways to neuroglobin transcriptional regulation. These data provide a glimpse of how neuroglobin expression may translate into neuronal diversity and function, as well as disease.
authors.affiliation: Center for Molecular Systems Biology, University of Turin, Orbassano, Turin, Italy; Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy.
authors.forename: Santina
authors.initials: S
authors.lastname: Cutrupi
authors.forename: Giulio
authors.initials: G
authors.lastname: Ferrero
authors.forename: Stefania
authors.initials: S
authors.lastname: Reineri
authors.forename: Francesca
authors.initials: F
authors.lastname: Cordero
authors.forename: Michele
authors.initials: M
authors.lastname: De Bortoli
mesh_terms: D001921:Brain / Q000378:metabolism*; D057890:Epigenomics; D005786:Gene Expression Regulation; D023281:Genomics; D005914:Globins / Q000235:genetics*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000235:genetics*; D000078787:Neuroglobin; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D000078787:Neuroglobin; D014157:Transcription Factors; D005914:Globins
keywords: genomics; neuroglobin; transcriptional regulation