title: External validation of a model for periconceptional prediction of recurrent early-onset preeclampsia.
abstract: OBJECTIVE
  To validate a previously published prediction model for recurrent early-onset preeclampsia (PE).
  
  
  METHODS
  We included 229 pregnant women with a history of early-onset PE and computed their risk using the prediction model, compared the predicted risk to their pregnancy outcomes and assessed performance of the model.
  
  
  RESULTS
  Early-onset PE recurred in 6.6% of participants. The area under the receiver operating characteristic curve was 59% (95% CI: 45-73). The model created groups that were only moderately different in terms of their risk.
  
  
  CONCLUSIONS
  The model's discriminate ability was poor and predictive performance insufficient to classify women into relevant risk groups.
authors.affiliation: Department of Obstetrics and Gynaecology, Maastricht University Medical Centre , Maastricht , the Netherlands .
authors.forename: S M
authors.initials: SM
authors.lastname: van Kuijk
authors.forename: D H
authors.initials: DH
authors.lastname: Delahaije
authors.forename: C D
authors.initials: CD
authors.lastname: Dirksen
authors.forename: H C
authors.initials: HC
authors.lastname: Scheepers
authors.forename: M E
authors.initials: ME
authors.lastname: Spaanderman
authors.forename: W
authors.initials: W
authors.lastname: Ganzevoort
authors.forename: J J
authors.initials: JJ
authors.lastname: Duvekot
authors.forename: M A
authors.initials: MA
authors.lastname: Oudijk
authors.forename: M G
authors.initials: MG
authors.lastname: van Pampus
authors.forename: P
authors.initials: P
authors.lastname: von Dadelszen
authors.forename: L L
authors.initials: LL
authors.lastname: Peeters
authors.forename: L J
authors.initials: LJ
authors.lastname: Smits
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008962:Models, Theoretical; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011247:Pregnancy; D012008:Recurrence; D012042:Registries; D018570:Risk Assessment
keywords: Early-onset; External validation; Prediction; Preeclampsia; Recurrence.