title: Primary squamous cell carcinoma of the breast: A rare case report.
abstract: BACKGROUND
  Squamous cells are normally not found inside the breast. Therefore, a primary squamous cell carcinoma of the breast is an exceptional phenomenon and the management of this type of disease is still debated.
  
  
  OBJECTIVE
  Clinical outcome assessment of a patient with squamous cell carcinoma of the breast.
  
  
  METHODS
  We report a case of primary squamous cell carcinoma of the breast (T1cN0M0) in a 51-years-old woman who underwent breast conserving surgery plus adjuvant chemotherapy and radiation therapy (RT).
  
  
  RESULTS
  With a follow up of 43 months, the patient is alive with no evidence of local or distant recurrence. The patient had Grade 2 acute skin toxicity. No late skin or respiratory toxicity was observed.
  
  
  CONCLUSIONS
  Pure primary squamous cell carcinoma of the breast is a rare and aggressive disease, often treatment-refractory. Our case shows that the addition of RT after breast conserving surgery, allows to achieve a high local control without adding severe toxicity. A multidisciplinary approach seems to be the optimal management for early stages in this rare disease.
authors.affiliation: Department of Radiation Oncology, Instituto Madrileño de Oncologia/Grupo IMO, Madrid, Spain.
authors.forename: Stefania
authors.initials: S
authors.lastname: Carbone
authors.affiliation: Department of Radiation Oncology, Instituto Oncologico de Castilla La Mancha/Grupo IMO, Toledo, Spain.
authors.forename: Rosabel
authors.initials: R
authors.lastname: Lobo Alvarez
authors.affiliation: Department of Radiation Oncology, Instituto Madrileño de Oncologia/Grupo IMO, Madrid, Spain ; Department of Radiation Oncology, University of Bari, Bari, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Lamacchia
authors.affiliation: Department of Radiology, Hospital Virgen de la Salud, Toledo, Spain.
authors.forename: Asuncion
authors.initials: A
authors.lastname: Almenar Gil
authors.affiliation: Department of Pathology, Hospital Virgen de la Salud, Toledo, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Martin Hernandez
authors.affiliation: Department of Radiation Oncology, Instituto Madrileño de Oncologia/Grupo IMO, Madrid, Spain.
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Lopez Guerra
authors.affiliation: Department of Radiation Oncology, Instituto Madrileño de Oncologia/Grupo IMO, Madrid, Spain ; Department of Radiation Oncology, Institut de cancérologie Gustave Roussy, Villejuif, Paris, France.
authors.forename: Hugo
authors.initials: H
authors.lastname: Marsiglia
keywords: Breast cancer; Outcome; Squamous cell carcinoma