title: The role of PGRN in musculoskeletal development and disease.
abstract: Progranulin (PGRN) is a growth factor that has been implicated in wound healing, inflammation, infection, tumorigenesis, and is most known for its neuroprotective and proliferative properties in neurodegenerative disease. This pleiotropic growth factor has been found to be a key player and regulator of a diverse spectrum of multi-systemic functions. Its critical anti-inflammatory role in rheumatoid arthritis and other inflammatory disease models has allowed for the propulsion of research to establish its significance in musculoskeletal diseases, including inflammatory conditions involving bone and cartilage pathology. In this review, we aim to elaborate on the emerging role of PGRN in the musculoskeletal system, reviewing its particular mechanisms described in various musculoskeletal diseases, with special focus on osteoarthritis and inflammatory joint disease patho-mechanisms and potential therapeutic applications of PGRN and its derivatives in these and other musculoskeletal diseases.
authors.affiliation: Department of Orthopaedic Surgery, New York University Medical Center, New York, NY, 10003.
authors.forename: Jessica
authors.initials: J
authors.lastname: Konopka
authors.affiliation: Department of Orthopaedic Surgery, New York University Medical Center, 301 East 17th Street, New York, NY 10003.
authors.forename: Brendon
authors.initials: B
authors.lastname: Richbourgh
authors.affiliation: Department of Orthopaedic Surgery, New York University Medical Center, 301 East 17th Street, New York, NY 10003.
authors.forename: Chuanju
authors.initials: C
authors.lastname: Liu
mesh_terms: D000818:Animals; D000077155:Granulins; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D051379:Mice; D041641:Musculoskeletal Development; D009140:Musculoskeletal Diseases / Q000503:physiopathology*; D000077153:Progranulins
chemical_list: D000077155:Granulins; C120204:Grn protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; D000077153:Progranulins