title: An approach to pleomorphic sarcomas: can we subclassify, and does it matter?
abstract: The term malignant fibrous histiocytoma (MFH) has been supplanted by undifferentiated pleomorphic sarcoma (UPS). Even now, however, a number of pleomorphic neoplasms are classified as UPSs when in fact at least a subgroup of these can be more precisely classified as a pleomorphic sarcoma with a specific line of differentiation. Still others are pseudosarcomas, most commonly sarcomatoid carcinomas. This review will discuss historical aspects of MFH/UPS as well as provide an approach to the pleomorphic malignant neoplasm with a discussion of useful ancillary techniques in the evaluation of such cases.
authors.affiliation: Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Goldblum
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D054337:Cell Dedifferentiation; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D011237:Predictive Value of Tests; D011379:Prognosis; D012509:Sarcoma / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000473:pathology; D009626:Terminology as Topic
chemical_list: D014408:Biomarkers, Tumor