title: Study of GOLPH3: a potential stress-inducible protein from Golgi apparatus.
abstract: Although the Golgi apparatus has been studied extensively for over 100 years, the complex structure-function relationships have yet to be elucidated. It is well known that the Golgi complex plays an important role in the transport, processing, sorting, and targeting of numerous proteins and lipids destined for secretion, plasma membrane, and lysosomes. Increasing evidence suggests that the Golgi apparatus is a sensor and common downstream effector of stress signals in cell death pathways. It undergoes disassembly and fragmentation in several neurological disorders. Recent studies indicate that Golgi phosphoprotein 3 (GOLPH3 also known as GPP34/GMx33/MIDAS), a peripheral membrane protein of trans-Golgi network, represents an exciting new class of oncoproteins involved in cell signal transduction and is potentially mobilized by stress. In this review, we focus on the importance of GOLPH3 in vesicular trafficking, Golgi architecture maintenance, receptor sorting, protein glycosylation, and further discuss its potential in signal sensing in stress response.
authors.affiliation: Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, 410011, People's Republic of China, lilisten2011@163.com.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: You
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoye
authors.initials: X
authors.lastname: Mo
authors.forename: Wenfang
authors.initials: W
authors.lastname: He
authors.forename: Yang
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiangqi
authors.initials: X
authors.lastname: Tang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiang
authors.forename: Ranran
authors.initials: R
authors.lastname: Tu
authors.forename: Liuwang
authors.initials: L
authors.lastname: Zeng
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Hu
mesh_terms: D000818:Animals; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology*; D015513:Oncogene Proteins / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
chemical_list: C429024:GOLPH3 protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins