title: Local injection of botulinum toxin A: an alternative therapy for axillary osmidrosis.
abstract: The objective of this study was to investigate the efficacy of local injection of botulinum toxin A for treating axillary osmidrosis. One hundred and fifty patients with axillary osmidrosis were randomly divided to receive botulinum toxin A injection treatment (50 U of botulinum toxin A was injected intracutaneously into 6-20 different sites within each axilla, n = 74) or surgical excision of the apocrine glands (n = 76). The patients were followed up for 1-3 months to analyze the therapeutic effect and complications of the two methods. The curative effect in patients with mild and moderate axillary osmidrosis was not significantly different between the botulinum toxin A injection group and operation group. However, for patients with severe axillary osmidrosis, surgery treatment seemed to be superior to botulinum toxin A treatment (P = 0.005). There was also no significant difference in the modified Dermatology Life Quality Index between the two treatments. Two cases showed complications related to hemorrhage and incision infection in the operation group. In conclusion, local injection of botulinum toxin A is a safe, fast and effective treatment for mild and moderate axillary osmidrosis, but the long-term effect remains to be further investigated.
authors.affiliation: Department of Plastic Surgery, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Aiguo
authors.initials: A
authors.lastname: Xie
authors.forename: Lanjun
authors.initials: L
authors.lastname: Nie
authors.forename: Qian
authors.initials: Q
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000328:Adult; D001050:Apocrine Glands / Q000187:drug effects* / Q000601:surgery; D001365:Axilla / Q000601:surgery*; D019274:Botulinum Toxins, Type A / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D013543:Sweat Gland Diseases / Q000188:drug therapy* / Q000601:surgery; D055815:Young Adult
chemical_list: D009498:Neurotoxins; D019274:Botulinum Toxins, Type A
keywords: Dermatology Life Quality Index; axillary osmidrosis; botulinum toxin A; therapeutic effect