title: [A case of gastric carcinosarcoma treated with surgical resection and irinotecan and mitomycin C combination therapy].
abstract: A 59-year-old man was admitted following episodes of melena. Upper gastrointestinal endoscopy revealed a type 2 carcinoid-like tumor in the cardium of the stomach. Histopathological analysis of a biopsy specimen revealed adenocarcinoma. Although hepatic metastases were detected, total gastrectomy was initially performed for hemorrhage control. The final histopathological diagnosis of the resected primary tumor was gastric carcinosarcoma with an osteosarcoma component. After ineffective first-line combination therapy with S-1 (tegafur, gimeracil, and oteracil) and cisplatin, irinotecan and mitomycin C chemotherapy was introduced. Although the hepatic metastases showed shrinkage after three courses of the chemotherapy, the patient succumbed seven months after surgery. This case report suggests that systemic chemotherapy using irinotecan and mitomycin C may be effective in the treatment of gastric carcinosarcoma with an osteosarcoma component and distant metastases.
authors.affiliation: Department of Gastroenterology, Asahi General Hospital.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Miyakawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Ayumi
authors.initials: A
authors.lastname: Takashina
authors.forename: Kazunaga
authors.initials: K
authors.lastname: Ishigaki
authors.forename: Yu
authors.initials: Y
authors.lastname: Iwai
authors.forename: Hiromi
authors.initials: H
authors.lastname: Abe
authors.forename: Tomoko
authors.initials: T
authors.lastname: Katagiri
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sakaguchi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Matsushima
authors.forename: Toshihide
authors.initials: T
authors.lastname: Tamura
authors.forename: Seiichi
authors.initials: S
authors.lastname: Komata
authors.forename: Manabu
authors.initials: M
authors.lastname: Kubota
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Akira
authors.initials: A
authors.lastname: Nakamura
authors.forename: Ei
authors.initials: E
authors.lastname: Itobayashi
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Shimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Shimura
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D002296:Carcinosarcoma / Q000628:therapy*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009362:Neoplasm Metastasis; D013274:Stomach Neoplasms / Q000628:therapy*
chemical_list: D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D016685:Mitomycin; D000077146:Irinotecan; D002166:Camptothecin