title: OTX1 promotes colorectal cancer progression through epithelial-mesenchymal transition.
abstract: Orthodenticle homeobox 1 (OTX1), a transcription factor containing a bicoid-like homeodomain, plays a role in brain and sensory organ development. In this study, we report that OTX1 is overexpressed in human colorectal cancer (CRC) and OTX1 overexpression is associated with higher stage. Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro. Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
authors.affiliation: Department of Colorectal Cancer Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Yu
authors.affiliation: Department of Colorectal Cancer Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Xin-Yi
authors.initials: XY
authors.lastname: Cai
authors.affiliation: Department of Colorectal Cancer Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Colorectal Cancer Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Zhi-Bin
authors.initials: ZB
authors.lastname: Yang
authors.affiliation: Department of Colorectal Cancer Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.affiliation: Department of Colorectal Cancer Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Shen
authors.affiliation: Department of Colorectal Cancer Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.
authors.forename: Wei-Ya
authors.initials: WY
authors.lastname: Wang
authors.affiliation: Department of Colorectal Cancer Surgery, Yunnan Tumor Hospital, The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China. Electronic address: ynsliyunfeng@163.com.
authors.forename: Yun-Feng
authors.initials: YF
authors.lastname: Li
mesh_terms: D063646:Carcinogenesis / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D018450:Disease Progression; D058750:Epithelial-Mesenchymal Transition / Q000235:genetics* / Q000502:physiology*; D045325:HCT116 Cells; D006801:Humans; D009857:Oncogenes; D051857:Otx Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics; D015854:Up-Regulation
chemical_list: C497655:OTX1 protein, human; D051857:Otx Transcription Factors; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D034741:RNA, Small Interfering
keywords: Colorectal cancer; Epithelial-mesenchymal; Invasion; OTX1; Proliferation