title: The many faces of mitophagy.
abstract: Failure to maintain mitochondrial integrity is linked to age‐related conditions, such as neurodegeneration. Two genes linked to Parkinson's disease, PINK1 and Parkin, play a key role in targeting the degradation of dysfunctional mitochondria (mitophagy). However, the mechanisms regulating the PINK1/Parkin pathway and other processes that impinge on mitochondrial turnover are poorly understood. Two articles in EMBO reports, by the Przedborski and Ganley groups, shed light on a new role for processed, cytoplasmic PINK1, and show that depletion of cellular iron levels stimulates PINK1/Parkin‐independent mitophagy.
authors.affiliation: Department of Biomedical Science MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK.
authors.forename: Rachael M
authors.initials: RM
authors.lastname: Ivatt
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Whitworth
mesh_terms: D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D063306:Mitophagy; D011494:Protein Kinases / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D000099202:PTEN-Induced Putative Kinase
chemical_list: D011494:Protein Kinases; D044767:Ubiquitin-Protein Ligases; D000099202:PTEN-Induced Putative Kinase; C111567:parkin protein