title: Murraya koenigii (L.) Spreng. ameliorates insulin resistance in dexamethasone-treated mice by enhancing peripheral insulin sensitivity.
abstract: BACKGROUND
  Murraya koenigii (L.) Spreng. is an important medicinal plant used traditionally as an antiemetic, antidiarrhoeal agent and blood purifier and as a medicine for a variety of ailments. This study investigated the effects of ethanolic extract of M. koenigii (MK) on diabetes-associated insulin resistance induced in mice by chronic low-dose injection of dexamethasone.
  
  
  RESULTS
  Mice treated with dexamethasone exhibited hyperglycaemia and impaired glucose tolerance. Treatment with MK reduced the extent of dexamethasone-induced hyperglycaemia and decreased insulin resistance as indicated by improved glucose tolerance and increased insulin-stimulated AKT phosphorylation in skeletal muscle tissue. Further evaluation in clonal skeletal muscle cell lines suggested that MK increased glucose uptake in L6 skeletal muscle cells by increasing cell surface GLUT4 density via an AKT-mediated pathway.
  
  
  CONCLUSIONS
  MK can ameliorate dexamethasone-induced hyperglycaemia and insulin resistance in part by increasing glucose disposal into skeletal muscle.
authors.affiliation: Division of Biochemistry, CSIR-Central Drug Research Institute, Lucknow, 226001, India.
authors.forename: Jyotsana
authors.initials: J
authors.lastname: Pandey
authors.forename: Ranjani
authors.initials: R
authors.lastname: Maurya
authors.forename: Rahul
authors.initials: R
authors.lastname: Raykhera
authors.forename: Mahendra N
authors.initials: MN
authors.lastname: Srivastava
authors.forename: Prem P
authors.initials: PP
authors.lastname: Yadav
authors.forename: Akhilesh K
authors.initials: AK
authors.lastname: Tamrakar
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003907:Dexamethasone; D018149:Glucose Intolerance / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D051379:Mice; D032101:Murraya; D018485:Muscle Fibers, Skeletal / Q000187:drug effects* / Q000378:metabolism; D010766:Phosphorylation; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D051275:Glucose Transporter Type 4; D007328:Insulin; D010936:Plant Extracts; D003907:Dexamethasone; D051057:Proto-Oncogene Proteins c-akt
keywords: Murraya koenigii; dexamethasone; glucose uptake; insulin resistance