title: Speciation studies of diorganotin(IV) complexes with 3,3-bis(1-methylimidazol-2-yl)propionate--displacement reaction by DNA constituents.
abstract: The interaction of 3,3-bis(1-methylimidazol-2-yl)propionate (BIMP) with dimethyltin(IV) dichloride (DMT), dibutyltin(IV) dichloride (DBT), and diphenyltin(IV) dichloride (DPT) is investigated at 25°C and 0.1 M ionic strength in water for dimethyltin(IV), and in a 50% dioxane-water mixture for dibutyltin(IV) and diphenyltin(IV). The stepwise formation constants of the 1 : 1 and 1 : 2 complexes formed in solution are calculated from potentiometric measurements using the nonlinear least-square program MINIQUAD-75. The concentration distribution of the various complex species is evaluated as a function of pH. Displacement reactions of the coordinated 3,3-bis(1-methylimidazol-2-yl)propionate by inosine and inosine-5'-monophosphate are investigated from calculations based upon equilibrium properties.
authors.affiliation: Department of Chemistry, Faculty of Science, Islamic University, Madina 170, Saudi Arabia ; Depatment of Chemistry, Faculty of Science, Cairo University, Cairo 12613, Egypt.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Shoukry
authors.affiliation: Depatment of Chemistry, Faculty of Science, Cairo University, Cairo 12613, Egypt.
authors.forename: Safaa S
authors.initials: SS
authors.lastname: Hassan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D007289:Cyclic IMP / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D004146:Dioxanes / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007093:Imidazoles / Q000737:chemistry*; D007288:Inosine / Q000737:chemistry; D016018:Least-Squares Analysis; D008024:Ligands; D009947:Organotin Compounds / Q000737:chemistry; D011199:Potentiometry; D011422:Propionates / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D002712:Chlorides; D004146:Dioxanes; D007093:Imidazoles; D008024:Ligands; D009947:Organotin Compounds; D011422:Propionates; D014867:Water; C056189:di-n-butyltin; C063612:diphenyltin; C039760:dimethyltin; D007289:Cyclic IMP; D007288:Inosine; D004247:DNA