title: Recyclable heparin and chitosan conjugated magnetic nanocomposites for selective removal of low-density lipoprotein from plasma.
abstract: A new fabrication protocol is described to obtain heparin and chitosan conjugated magnetic nanocomposite as a blood purification material for removal of low-density lipoprotein (LDL) from blood plasma. The adsorbent could be easily separated with an external magnet for recyclable use since it had a magnetic core. The LDL level of plasma decreased by 67.3 % after hemoperfusion for 2 h. Moreover, the adsorbent could be recycled simply washing with NaCl solution. After eight cycles, the removal efficiency of the adsorbent was still above 50 %. The recyclable magnetic adsorbent had good blood compatibility due to the conjugation of heparin to the chitosan-coated magnetic nanocomposites. The fabricated magnetic adsorbent could be applied for LDL apheresis without side effects.
authors.affiliation: Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, 400044, People's Republic of China.
authors.forename: Jinghua
authors.initials: J
authors.lastname: Li
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Hou
authors.forename: Xiuyong
authors.initials: X
authors.lastname: Chen
authors.forename: Xingwei
authors.initials: X
authors.lastname: Ding
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Xinkun
authors.initials: X
authors.lastname: Shen
authors.forename: Kaiyong
authors.initials: K
authors.lastname: Cai
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry; D001781:Blood Component Removal; D048271:Chitosan / Q000737:chemistry*; D006493:Heparin / Q000737:chemistry*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000628:therapy; D008077:Lipoproteins, LDL / Q000097:blood* / Q000302:isolation & purification*; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D059027:Recycling
chemical_list: D001672:Biocompatible Materials; D008077:Lipoproteins, LDL; D058185:Magnetite Nanoparticles; D006493:Heparin; D048271:Chitosan