title: Nanoparticles with dual responses to oxidative stress and reduced ph for drug release and anti-inflammatory applications.
abstract: Oxidative stress and reduced pH are involved in many inflammatory diseases. This study describes a nanoparticle-based system that is responsive to both oxidative stress and reduced pH in an inflammatory environment to effectively release its encapsulated curcumin, an immune-modulatory agent with potent anti-inflammatory and antioxidant capabilities. Because of the presence of Förster resonance energy transfer between curcumin and the carrier, this system also allowed us to monitor the intracellular release behavior. The curcumin released upon triggering could efficiently reduce the excess oxidants produced by the lipopolysaccharide (LPS)-stimulated macrophages. The feasibility of using the curcumin-loaded nanoparticles for anti-inflammatory applications was further validated in a mouse model with ankle inflammation induced by LPS. The results of these studies demonstrate that the proposed nanoparticle system is promising for treating oxidative stress-related diseases.
authors.affiliation: Department of Chemical Engineering and Institute of Biomedical Engineering, National Tsing Hua University , Hsinchu 30013, Taiwan (ROC).
authors.forename: Hsiao-Lan
authors.initials: HL
authors.lastname: Pu
authors.forename: Wei-Lun
authors.initials: WL
authors.lastname: Chiang
authors.forename: Barnali
authors.initials: B
authors.lastname: Maiti
authors.forename: Zi-Xian
authors.initials: ZX
authors.lastname: Liao
authors.forename: Yi-Cheng
authors.initials: YC
authors.lastname: Ho
authors.forename: Min Suk
authors.initials: MS
authors.lastname: Shim
authors.forename: Er-Yuan
authors.initials: EY
authors.lastname: Chuang
authors.forename: Younan
authors.initials: Y
authors.lastname: Xia
authors.forename: Hsing-Wen
authors.initials: HW
authors.lastname: Sung
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D006863:Hydrogen-Ion Concentration; D053758:Nanoparticles; D018384:Oxidative Stress
chemical_list: D000893:Anti-Inflammatory Agents; D004337:Drug Carriers