title: [Relationship between CNTF gene polymorphism and athletes training adaptation of muscle tissue].
abstract: OBJECTIVE
  To explore the relationship between CNTF gene polymorphism and athletes training adaptation of muscle tissue.
  
  
  METHODS
  A total of 215 new students without a training history CNTF genotype were recruited from a sports college. During training, the changes in test object biceps muscle belly cross-sectional area, muscle fatigue and muscle damage related biochemical indices were detected. And the impact of gene polymorphism was analyzed on the detection results.
  
  
  RESULTS
  After training, biceps brachii muscle cross-sectional areas showed different degrees of growth and the GG gene type growth was greater than other genotypes (P < 0.05) . At post-training physical examination, all subjects of muscle fatigue and muscle damage index were higher than those of the control group, but no obvious difference existed between examination groups.In basic training at the end of physical examination, the related indices of each group were higher than those of the control group, but the values of lactic acid, blood urea nitrogen and serum CK value were lower for object type GG than those for the other groups [ (234.7±57.5) vs (84.7±24.7) U, (5.8±0.8) vs (4.3±0.6) mmol/L, (271.5±98.7) vs (59.2±35.6) U] (P < 0.05).
  
  
  CONCLUSIONS
  During training, muscle cross-sectional area of GG genotype grows more while the serum levels of muscle injury are significantly lower than those of other groups. In summary, GG genotype has better muscle training adaptation than GA and AA.
authors.affiliation: All-army Military Drill Research Institute of Medicine, No.150 PLA Hospital, Luoyang 100842, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhang
authors.affiliation: All-army Military Drill Research Institute of Medicine, No.150 PLA Hospital, Luoyang 100842, China. Email: huangchanglin1945@263.net.
authors.forename: Chang-lin
authors.initials: CL
authors.lastname: Huang
authors.affiliation: All-army Military Drill Research Institute of Medicine, No.150 PLA Hospital, Luoyang 100842, China.
authors.forename: Yu-xuan
authors.initials: YX
authors.lastname: Chen
mesh_terms: D000222:Adaptation, Physiological; D000293:Adolescent; D056352:Athletes; D020934:Ciliary Neurotrophic Factor / Q000235:genetics*; D015444:Exercise; D005838:Genotype; D006801:Humans; D008297:Male; D009132:Muscles / Q000502:physiology*; D011110:Polymorphism, Genetic
chemical_list: D020934:Ciliary Neurotrophic Factor