title: Light regulation of cadmium-induced cell death in Arabidopsis.
abstract: Cadmium is an environmental pollutant with deleterious effects on both prokaryotic and eukaryotic organisms. In plants, the effects of cadmium toxicity are concentration dependent; lower doses destabilize many physiological processes and inhibit cell growth and multiplication, while higher doses evoke a more severe response that triggers activation of cell death. We recently investigated the effects of light on cadmium toxicity in Arabidopsis using a cell suspension culture system. Although not affecting the inhibitory effects on cell multiplication, we found that light is a powerful regulator of Cd-induced cell death. A very specific proteomic response, which was clearly controlled by light, preceded cell death. Here we discuss the implications of these findings and highlight similarities between the regulation of cell death triggered by Cd and fumonisin B1. We consider how both compounds could be useful tools in dissecting plant cell death signaling.
authors.affiliation: School of Biological and Biomedical Sciences; Durham University; Durham, UK.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Smith
authors.affiliation: School of Food and Biological Engineering; Jiangsu University; Zhenjiang, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: School of Biological and Biomedical Sciences; Durham University; Durham, UK.
authors.forename: Antoni R
authors.initials: AR
authors.lastname: Slabas
authors.affiliation: School of Biological and Biomedical Sciences; Durham University; Durham, UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Chivasa
mesh_terms: D017360:Arabidopsis / Q000187:drug effects* / Q000528:radiation effects; D002104:Cadmium / Q000633:toxicity*; D016923:Cell Death / Q000187:drug effects; D008027:Light
chemical_list: D002104:Cadmium
keywords: Arabidopsis thaliana; Fumonisin B1; cadmium; cell death; light regulation