title: Clinical aggression of prolactinomas: correlations with invasion and recurrence.
abstract: Some hypophyseal adenomas are discrete, well-marked lesions, which can be curatively removed by surgical resection, while others seem aggressive, invasive, recidive-prone, most often progressing in spite of any pharmacological, surgical or radiotherapeutical interventions. There is also a great variability within the incidence of aggression and invasion among the various types of hypophyseal immunotypes. Despite their well-differentiated nature and their "benign" constitution, an important number of hypophyseal tumors will be surely invasive within the sclerous, osseous and neural structures. Because the aggressive behavior of invasive adenomas is generally resolved by surgical treatment, this aspect of their biology does not perfectly reflect within their histopathological aspect. In fact, the invasive tumors with local extreme aggression are most often deceiving due to their relatively harmless histopathological aspect. The usual morphological signs of tumor aggression, namely pleomorphism, nuclear atypia, hemorrhage, high cellular and mitotic activity, poorly correlate with the invasive potential of pituitary tumors, with their proliferation capacity, their tendency of post-surgical recurrence or with their global biological behavior.
authors.affiliation: Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania; mihaelavoica123@yahoo.co.uk, elena.ionesc@yahoo.com.
authors.forename: Mihaela N
authors.initials: MN
authors.lastname: Popescu
authors.forename: Elena
authors.initials: E
authors.lastname: Ionescu
authors.forename: L C
authors.initials: LC
authors.lastname: Iovănescu
authors.forename: B V
authors.initials: BV
authors.lastname: Cotoi
authors.forename: A I
authors.initials: AI
authors.lastname: Popescu
authors.forename: Anca Elena
authors.initials: AE
authors.lastname: Gănescu
authors.forename: Adina
authors.initials: A
authors.lastname: Glodeanu
authors.forename: Cristiana
authors.initials: C
authors.lastname: Geormăneanu
authors.forename: Andreiana
authors.initials: A
authors.lastname: Moraru
authors.forename: Anca
authors.initials: A
authors.lastname: Pătraşcu
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002648:Child; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000378:metabolism / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology; D011388:Prolactin / Q000378:metabolism; D015175:Prolactinoma / Q000378:metabolism / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D047368:Tumor Burden; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D055815:Young Adult
chemical_list: D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53; D011388:Prolactin