title: On locating the obstruction in the upper airway via numerical simulation.
abstract: The fluid dynamical properties of the air flow in the upper airway (UA) are not fully understood at present due to the three-dimensional (3D) patient-specific complex geometry of the airway, flow transition from laminar to turbulent and flow-structure interaction during the breathing cycle. It is quite difficult at present to experimentally measure the instantaneous velocity and pressure at specific points in the human airway. On the other hand, direct numerical simulation (DNS) can predict all the flow properties and resolve all its relevant length- and time-scales. We developed a DNS solver with the state-of-the-art lattice Boltzmann method (LBM), and used it to investigate the flow in two patient-specific UAs reconstructed from CT scan data. Inspiration and expiration flows through these two airways are studied. The time-averaged first spatial derivative of pressure (pressure gradient), ∂p/∂z, is used to locate the region of the UA obstruction. But the time-averaged second spatial derivative, ∂(2)p/∂z(2), is used to pinpoint the exact location of the obstruction. The present results show that the DNS-LBM solver can be used to obtain accurate flow details in the UA and is a powerful tool to locate its obstruction.
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of California, Irvine, CA 92697, USA.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Mechanical and Aerospace Engineering, University of California, Irvine, CA 92697, USA. Electronic address: selghoba@uci.edu.
authors.forename: S
authors.initials: S
authors.lastname: Elghobashi
mesh_terms: D000402:Airway Obstruction / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002648:Child; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D045853:Exhalation / Q000502:physiology; D006801:Humans; D006984:Hypertrophy / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D001239:Inhalation / Q000502:physiology; D007830:Larynx / Q000000981:diagnostic imaging / Q000503:physiopathology; D008953:Models, Anatomic; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000503:physiopathology; D009305:Nasopharynx / Q000000981:diagnostic imaging / Q000503:physiopathology; D009960:Oropharynx / Q000000981:diagnostic imaging / Q000503:physiopathology; D011312:Pressure; D012137:Respiratory System / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013997:Time Factors; D014057:Tomography, X-Ray Computed
keywords: Direct numerical simulation; Lattice Boltzmann; Obstruction; Second derivative of pressure; Turbulent; Upper airway