title: Sleep deprivation during a specific 3-hour time window post-training impairs hippocampal synaptic plasticity and memory.
abstract: Sleep deprivation disrupts hippocampal function and plasticity. In particular, long-term memory consolidation is impaired by sleep deprivation, suggesting that a specific critical period exists following learning during which sleep is necessary. To elucidate the impact of sleep deprivation on long-term memory consolidation and synaptic plasticity, long-term memory was assessed when mice were sleep deprived following training in the hippocampus-dependent object place recognition task. We found that 3h of sleep deprivation significantly impaired memory when deprivation began 1h after training. In contrast, 3 h of deprivation beginning immediately post-training did not impair spatial memory. Furthermore, a 3-h sleep deprivation beginning 1h after training impaired hippocampal long-term potentiation (LTP), whereas sleep deprivation immediately after training did not affect LTP. Together, our findings define a specific 3-h critical period, extending from 1 to 4h after training, during which sleep deprivation impairs hippocampal function.
authors.affiliation: Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Toni-Moi
authors.initials: TM
authors.lastname: Prince
authors.affiliation: Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Wimmer
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Choi
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Robbert
authors.initials: R
authors.lastname: Havekes
authors.affiliation: Department of Molecular, Cellular & Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Aton
authors.affiliation: Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: abele@sas.upenn.edu.
authors.forename: Ted
authors.initials: T
authors.lastname: Abel
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000503:physiopathology*; D017774:Long-Term Potentiation; D008297:Male; D057567:Memory, Long-Term / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D021641:Recognition, Psychology / Q000502:physiology; D012892:Sleep Deprivation / Q000503:physiopathology*; D013028:Space Perception / Q000502:physiology; D013997:Time Factors
keywords: Hippocampus; Long-term potentiation; Sleep loss; Spatial memory