title: Evaluation of the pharmacological properties of salicylic acid-derivative organoselenium: 2-hydroxy-5-selenocyanatobenzoic acid as an anti-inflammatory and antinociceptive compound.
abstract: The present study evaluated the antinociceptive and anti-inflammatory effects of per oral (p.o.) administration of salicylic acid-derivative organoselenium compounds in chemical models of nociception in mice. The compounds (50 mg/kg; p.o.) were administered 30 and 60 min before the nociceptive behavior and compared to the positive-control, acetylsalicylic acid (ASA; 200 mg/kg; p.o.). In addition, a dose-response curve (25-100 mg/kg) for compounds was carried out in the formalin test. When assessed in the chemical models, acetic acid-induced writhing behavior, formalin and glutamate tests, the compounds showed the following antinociceptive profile 1B>2B>1A>2A, suggesting a chemical structure-dependent relationship. Then, the anti-inflammatory properties and toxicological potential of compound 1B were investigated. Compound 1B, similar to the positive-control, ASA, diminished the edema formation and decreased the myeloperoxidase activity induced by croton oil (2.5%) in the ear tissue. The results also indicate that a single oral administration of 1B caused neither signs of acute toxicity nor those of gastrointestinal injury. The administration of 1B did not alter the water and food intakes, plasma alanine and aspartate aminotransferase activities or urea levels and cerebral or hepatic δ-aminolevulinate dehydratase activity. Salicylic acid-derivative organoseleniums, mainly compound 1B, have been found to be novel compounds with antinociceptive/anti-inflammatory properties; nevertheless, more studies are required to examine their therapeutic potential for pain treatment.
authors.affiliation: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Universidade Federal de Santa Maria, CEP 97105-900 Santa Maria, RS, Brazil.
authors.forename: Pietro Maria
authors.initials: PM
authors.lastname: Chagas
authors.affiliation: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Universidade Federal de Santa Maria, CEP 97105-900 Santa Maria, RS, Brazil.
authors.forename: Suzan Gonçalves
authors.initials: SG
authors.lastname: Rosa
authors.affiliation: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Universidade Federal de Santa Maria, CEP 97105-900 Santa Maria, RS, Brazil.
authors.forename: Marcel Henrique Marcondes
authors.initials: MH
authors.lastname: Sari
authors.affiliation: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Universidade Federal de Santa Maria, CEP 97105-900 Santa Maria, RS, Brazil.
authors.forename: Carla Elena Sartori
authors.initials: CE
authors.lastname: Oliveira
authors.affiliation: Departamento de Química, Universidade Federal de Santa Catarina, CEP 88040-900 Florianópolis, SC, Brazil.
authors.forename: Rômulo Faria Santos
authors.initials: RF
authors.lastname: Canto
authors.affiliation: Departamento de Patologia, Universidade Federal de Santa Maria, CEP 97105-900 Santa Maria, RS, Brazil.
authors.forename: Sônia Cristina Almeida
authors.initials: SC
authors.lastname: da Luz
authors.affiliation: Departamento de Química, Universidade Federal de Santa Catarina, CEP 88040-900 Florianópolis, SC, Brazil.
authors.forename: Antonio Luiz
authors.initials: AL
authors.lastname: Braga
authors.affiliation: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Universidade Federal de Santa Maria, CEP 97105-900 Santa Maria, RS, Brazil. Electronic address: criswn@quimica.ufsm.br.
authors.forename: Cristina Wayne
authors.initials: CW
authors.lastname: Nogueira
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D016566:Organoselenium Compounds / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D010147:Pain Measurement; D009195:Peroxidase / Q000378:metabolism; D026361:Reactive Nitrogen Species / Q000378:metabolism; D012459:Salicylates / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity
chemical_list: C000592693:2-hydroxy-5-selenocyanatobenzoic acid; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016566:Organoselenium Compounds; D026361:Reactive Nitrogen Species; D012459:Salicylates; D009195:Peroxidase; D001241:Aspirin
keywords: Inflammation; Mice; Nociception; Salicylate; Selenium; Toxicity