title: MicroRNAs -the next generation therapeutic targets in human diseases.
abstract: MicroRNAs (miRNAs), an abundant class of ~22-nucleotide non-coding RNAs, regulate the expression of genes at post transcriptional level. MiRNAs are important regulators of eukaryotic gene expression and therefore implicated in a wide range of biological processes. The miRNA-related genetic alterations are possibly more implicated human diseases than currently appreciated. Genetic variants in miRNA target sites, called miRNA genes are identified to be associated with human diseases. This review discusses about the role of micro-RNA genes in various human diseases such as neurodegenerative disorders, cardio-vascular diseases, and metabolic disorders, and how they can be targeted as a new therapeutic tool in future with reference to drug discoveries/ development.
authors.affiliation: 1. Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, X-Frontier Block, Singapore-637553.
authors.forename: Sakthivel
authors.initials: S
authors.lastname: Srinivasan
authors.affiliation: 2. Institute of Materials Research and Engineering, 3 Research Link, Singapore-117602.
authors.forename: Subramanian Tamil
authors.initials: ST
authors.lastname: Selvan
authors.affiliation: 3. Centre for Pheromone Technology (CPT), Department of Animal Science, Bharathidasan University, Tiruchirappalli- 620 024, India.
authors.forename: Govindaraju
authors.initials: G
authors.lastname: Archunan
authors.affiliation: 1. Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, X-Frontier Block, Singapore-637553.
authors.forename: Balazs
authors.initials: B
authors.lastname: Gulyas
authors.affiliation: 1. Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Research Techno Plaza, Level 4, X-Frontier Block, Singapore-637553.
authors.forename: Parasuraman
authors.initials: P
authors.lastname: Padmanabhan
mesh_terms: D002318:Cardiovascular Diseases / Q000628:therapy; D005786:Gene Expression Regulation; D006801:Humans; D008659:Metabolic Diseases / Q000628:therapy; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D062346:Molecular Medicine / Q000379:methods*; D058990:Molecular Targeted Therapy / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000628:therapy
chemical_list: D035683:MicroRNAs
keywords: Cardio-vascular diseases and metabolic disorders; Neurodegenerative disorders; miRNA therapy; novel therapeutics