title: A brief history of epigenetics.
abstract: The term "epigenetics" was originally used to denote the poorly understood processes by which a fertilized zygote developed into a mature, complex organism. With the understanding that all cells of an organism carry the same DNA, and with increased knowledge of mechanisms of gene expression, the definition was changed to focus on ways in which heritable traits can be associated not with changes in nucleotide sequence, but with chemical modifications of DNA, or of the structural and regulatory proteins bound to it. Recent discoveries about the role of these mechanisms in early development may make it desirable to return to the original definition of epigenetics.
authors.affiliation: National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0540.
authors.forename: Gary
authors.initials: G
authors.lastname: Felsenfeld
mesh_terms: D002843:Chromatin / Q000502:physiology; D004247:DNA / Q000235:genetics; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D049673:History, 20th Century; D049674:History, 21st Century
chemical_list: D002843:Chromatin; D004247:DNA