title: Copper-catalyzed aerobic oxidative coupling of aromatic alcohols and acetonitrile to β-ketonitriles.
abstract: A practical, convenient, and cheap copper-catalyzed aerobic oxidative coupling of aromatic alcohols and acetonitrile to β-ketonitriles has been developed. The green C-C bond formation involving the loss of two hydrogen atoms from the corresponding two carbons, respectively, unlocks opportunities for markedly different synthetic strategies.
authors.affiliation: School of Pharmacy, East China University of Science and Technology , Meilong Road 130, Shanghai 200237, China.
authors.forename: Jiaxuan
authors.initials: J
authors.lastname: Shen
authors.forename: Dejun
authors.initials: D
authors.lastname: Yang
authors.forename: Yuxiao
authors.initials: Y
authors.lastname: Liu
authors.forename: Shuangshuang
authors.initials: S
authors.lastname: Qin
authors.forename: Jingwu
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiangkai
authors.initials: J
authors.lastname: Sun
authors.forename: Chunhui
authors.initials: C
authors.lastname: Liu
authors.forename: Chaoyang
authors.initials: C
authors.lastname: Liu
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Zhao
authors.forename: Changhu
authors.initials: C
authors.lastname: Chu
authors.forename: Renhua
authors.initials: R
authors.lastname: Liu
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006859:Hydrogen; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D058451:Oxidative Coupling
chemical_list: D000438:Alcohols; D007659:Ketones; D009570:Nitriles; D003300:Copper; D006859:Hydrogen; C029892:cupric chloride