title: Effect of gestational diabetes on blood sugar, liver and renal function tests.
abstract: OBJECTIVE
  Type 2 diabetes adversely affects the liver and kidney function tests. This study was conducted to determine that either the liver and kidney functions are disturbed in the patients having gestational diabetes mellitus (GDM).
  
  
  METHODS
  One hundred and three women with GDM, and 97 healthy pregnant women (HPW) in their third trimester were registered in the Obs/Gyn Unit of Khyber Teaching Hospital, Peshawar in the time period Apr-Sep 2012. Blood sugar level, glycosylated haemoglobin status HbAlc, haemoglobin concentration, platelet count, liver function tests including alanine amino transferase (ALT), alkaline phosphatase (ALP) and bilirubin, renal function tests including urea and creatinine were determined.
  
  
  RESULTS
  Blood glucose level and HbAlc of GDM was significantly higher (p < 0.001) than HPW. Fasting and random blood glucose and HbA1c of GDM and HPW were 110.90 +/- 9.10 vs 84.68 +/- 7.01 mg/dl, 148.53 +/- 7.21 vs 124.42 +/- 9.46 mg/dl and 6.49 +/- 1.20 vs 4.99 +/- 0.55 respectively. Haemoglobin percentage, platelet count, ALT, ALP, serum bilirubin and urea were not significantly different among the two groups. However, mean serum creatinine (0.82 +/- 0.32 mg/dl) in GDM was significantly higher (p < 0.05) than in HPW (0.74 +/- 0.15 mg/dl).
  
  
  CONCLUSIONS
  In gestational diabetes the LFTs may not be disturbed, however serum creatinine value is increased.
authors.affiliation: Department of Biochemistry, Khyber Girls Medical College, Pakistan. radhiakhan@yahoo.com
authors.forename: Radhia
authors.initials: R
authors.lastname: Khan
authors.affiliation: Department of Gynaecology, Khyber Teaching Hospital, Pakistan.
authors.forename: Zakkia
authors.initials: Z
authors.lastname: Khan
authors.affiliation: Department of Pathology, Khyber Girls Medical College, Pakistan.
authors.forename: Khalid
authors.initials: K
authors.lastname: Javed
authors.affiliation: lnstitute of Chemical Sciences, University of Peshawar, Pakistan.
authors.forename: Khurshid
authors.initials: K
authors.lastname: Ali
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D016022:Case-Control Studies; D003404:Creatinine / Q000378:metabolism; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007677:Kidney Function Tests; D008111:Liver Function Tests; D010976:Platelet Count; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin