title: A natural meliorate: revolutionary tissue engineering in endodontics.
abstract: Platelet-Rich Fibrin (PRF) was first described by Choukroun et al., (2001). It has been referred to as a second-generation platelet concentrate, which has been shown to have several advantages over traditionally prepared platelet-rich plasma. PRF has a physiologic architecture that is very favourable to the healing process, obtained due to the slow polymerization process. The development of platelet concentrate as bioactive surgical additives that are applied locally to promote wound healing stems from the use of fibrin adhesive. Developments in the field of tissue engineering have made the generation of artificial substitutes in several areas of medicine. Various clinical applications in endodontics include Periapical surgeries, Revascularisationprocedures, Regenerative pulpotomy, Perforation repair. This article aims to discuss the various applications of PRF in the field of Endodontics with few case reports.
authors.affiliation: Professor and HOD, Department of Conservative Dentistry and Endodontics, Rajarajeswari Dental College , Bangalore, Karnataka, India .
authors.forename: I B
authors.initials: IB
authors.lastname: Geeta
authors.affiliation: Professor and HOD, Department of Prosthodonics Including Crown and Bridge, Navodaya Dental College , Raichur, Karnataka, India .
authors.forename: Girish
authors.initials: G
authors.lastname: Galagali
authors.affiliation: Senior Lecturer, Department of Conservative Dentistry and Endodontics, Al Badad Dental College , Gulbarga, Karnataka, India .
authors.forename: Sangeeta
authors.initials: S
authors.lastname: Kulkarni
authors.affiliation: Reader, Department of Conservative Dentistry and Endodontics, Government Dental College , Bellary, Karnataka, India .
authors.forename: Pushpa
authors.initials: P
authors.lastname: Suran
authors.affiliation: Post Graduate, Department of Conservative Dentistry And Endodontics, Rajarajeswari Dental College , Bangalore, Karnataka, India .
authors.forename: Faizal
authors.initials: F
authors.lastname: Noushin
keywords: Apexification; Platelet rich fibrin; Pulpotomy; Tissue engineering