title: Inflammation and human cerebral aneurysms: current and future treatment prospects.
abstract: The formation of cerebral aneurysms and their rupture propensity is of immediate clinical importance. Current management includes observation with expectant management, microsurgical clipping and/or endovascular coiling. The surgical options are invasive and are not without increased risk despite the technological advances. Recent human and animal studies have shown that inflammation plays a critical role in aneurysm formation and progression to rupture. Modulating this inflammatory process may prove to be clinically significant. This review will discuss cerebral aneurysm pathogenesis with a focus on current and future research of potential use of pharmaceutical agents that attenuate inflammation in the aneurysm wall leading to decreased risk of aneurysm rupture.
authors.affiliation: University of Iowa, Iowa City IA, USA.
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Hudson
authors.affiliation: Department of Otolaryngology University of Iowa Carver College of Medicine, Iowa City, IA, USA.
authors.forename: Danielle S
authors.initials: DS
authors.lastname: Hoyne
authors.affiliation: Department of Neurosurgery, University of Iowa Hospitals & Clinics, 200 Hawkins Drive, Iowa City, IA 52240, USA.
authors.forename: David M
authors.initials: DM
authors.lastname: Hasan
keywords: cerebral aneurysm; ferumoxytol; inflammation; macrophages; subarachnoid hemorrhage