title: Modular automated solid phase synthesis of dermatan sulfate oligosaccharides.
abstract: Dermatan sulfates are glycosaminoglycan polysaccharides that serve a multitude of biological roles as part of the extracellular matrix. Orthogonally protected D-galactosamine and L-iduronic acid building blocks and a photo-cleavable linker are instrumental for the automated synthesis of dermatan sulfate oligosaccharides. Conjugation-ready oligosaccharides were obtained in good yield.
authors.affiliation: Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany. peter.seeberger@mpikg.mpg.de.
authors.forename: Jeyakumar
authors.initials: J
authors.lastname: Kandasamy
authors.forename: Frank
authors.initials: F
authors.lastname: Schuhmacher
authors.forename: Heung Sik
authors.initials: HS
authors.lastname: Hahm
authors.forename: James C
authors.initials: JC
authors.lastname: Klein
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
mesh_terms: D001331:Automation; D002240:Carbohydrate Sequence; D003871:Dermatan Sulfate / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D060327:Solid-Phase Synthesis Techniques
chemical_list: D009844:Oligosaccharides; D003871:Dermatan Sulfate