title: IgE anti Hepatitis B virus surface antigen antibodies detected in serum from inner city asthmatic and non asthmatic children.
abstract: Viral Hepatitis type B (HBV) is a public health concern, but has not been linked to asthma. Immunoglobulin (Ig) G is involved in HBV immune responses; less is known about IgE antibodies (Abs) against HBV in asthma. Given the importance of HBV, we sought to determine whether HBV vaccine contributes to asthma in children, by stimulating specific IgE production. Total IgE, IgE- or IgG-anti-HBVs Abs were studied in vaccinated pediatric asthmatics and non asthmatics. We found: (1) total IgE was higher in asthmatics; (2) total IgE did not correlate with IgE anti-HBVs; (3) IgE anti-HBVs did correlate with IgG-anti-HBVs in all subjects; (4)IgE- and IgG-HBVs Abs were similar in both groups; (5) IgE- or IgG anti-HBVs Abs did not correlate with age. Our findings indicate that HBV vaccination induces IgE responses in asthmatics and non asthmatics.
authors.affiliation: Department of Pediatrics, Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY 11203, United States. Electronic address: tamar.smith-norowitz@downstate.edu.
authors.forename: Tamar A
authors.initials: TA
authors.lastname: Smith-Norowitz
authors.affiliation: Department of Pediatrics, Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY 11203, United States.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Tam
authors.affiliation: Department of Pediatrics, Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY 11203, United States.
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Norowitz
authors.affiliation: Department of Pediatrics, Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY 11203, United States.
authors.forename: Kobkul
authors.initials: K
authors.lastname: Chotikanatis
authors.affiliation: Department of Pediatrics, Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY 11203, United States.
authors.forename: Diana
authors.initials: D
authors.lastname: Weaver
authors.affiliation: Department of Pathology, Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY 11203, United States.
authors.forename: Helen G
authors.initials: HG
authors.lastname: Durkin
authors.affiliation: Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, United States.
authors.forename: Martin H
authors.initials: MH
authors.lastname: Bluth
authors.affiliation: Department of Pediatrics, Center for Allergy and Asthma Research, S.U.N.Y. Downstate Medical Center, Brooklyn, NY 11203, United States.
authors.forename: Stephan
authors.initials: S
authors.lastname: Kohlhoff
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000097:blood / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008297:Male; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D007074:Immunoglobulin G; D007073:Immunoglobulin E