title: Translational strategies for neuroprotection in ischemic stroke--focusing on acid-sensing ion channel 1a.
abstract: Ischemic stroke contributes to the majority of brain injuries and remains to be a leading cause of death and long-term disability. Despite the devastating pathology and high incidence of disease, there remain only few treatment options (TPA and endovascular procedures), which may be hampered by time-dependent administration among a variety of other factors. Promising research of glutamate receptor antagonists has been unsuccessful in clinical trial. But, the mechanism by which glutamate receptors initiate injury by excessive calcium overload has spurred investigation of new and potentially successful candidates for stroke therapy. Acid-sensing ion channels (ASICs) may contribute to poor stroke prognosis due to localized drop in brain pH, resulting in excessive calcium overload, independent of glutamate activation. Accumulating studies targeting ASICs have underscored the importance of understanding inhibition, regulation, desensitization, and trafficking of this channel and its role in disease. This review will discuss potential directions in translational ASIC research for future stroke therapies.
authors.affiliation: Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr. SW, Atlanta, GA, 30310, USA.
authors.forename: Zaven
authors.initials: Z
authors.lastname: O'Bryant
authors.forename: Kiara T
authors.initials: KT
authors.lastname: Vann
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Xiong
mesh_terms: D062646:Acid Sensing Ion Channel Blockers / Q000627:therapeutic use; D062565:Acid Sensing Ion Channels / Q000378:metabolism*; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D018696:Neuroprotective Agents / Q000627:therapeutic use; D020521:Stroke / Q000378:metabolism*; D057170:Translational Research, Biomedical
chemical_list: D062646:Acid Sensing Ion Channel Blockers; D062565:Acid Sensing Ion Channels; D018696:Neuroprotective Agents