title: Study the effect of s-methyl L-cysteine on lipid metabolism in an experimental model of diet induced obesity.
abstract: BACKGROUND
  S-methyl L-cysteine (SMC) is a hydrophilic cysteine-containing compound naturally found in Alium plants such as, garlic and onion.
  
  
  OBJECTIVE
  The present study was aimed to evaluate the hypoglycemic and antihyperlipidemic properties of SMC in high fructose induced diabetic rats.
  
  
  METHODS
  The present study was designed to evaluate the hypoglycemic and antihyperlipidemic properties of SMC in high fructose induced diabetic rats. Blood samples were collected and the fasting plasma glucose, lipid profile, total antioxidant status (TAS) aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were estimated using standard procedures. Differences between the groups were assessed by using One way Analysis of Variance with (ANOVA) Tukey post hoc test.
  
  
  RESULTS
  Oral administration of SMC at a dose of 100 mg/kg bodyweight/day to HFD-treated rats for a period of 60 days showed significant reduction in the animal weight, fasting plasma glucose, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), VLDL-C and elevation in the level of high-density lipoprotein cholesterol (HDL-C) and TAS compared with fructose fed group. The effects of SMC was compared with metformin; a well-known antihyperglycemic drug.
  
  
  CONCLUSIONS
  In conclusion, SMC found to be effective in improving the high fructose induced hyperglycemia and dyslipidemia. It may possibly provide a potential adjuvant for the treatment and management of diabetes.
authors.affiliation: Lecturer, Department of Biochemistry, JIPMER , Pondicherry- 605 006, India .
authors.forename: Senthilkumar
authors.initials: S
authors.lastname: G P
authors.affiliation: Post Graduate, Medical Biochemistry Student, JIPMER , Pondicherry- 605 006, India .
authors.forename: Sithara
authors.initials: S
authors.lastname: Thomas
authors.affiliation: Post Graduate, Medical Biochemistry Student, JIPMER , Pondicherry- 605 006, India .
authors.forename: Sivaraman
authors.initials: S
authors.lastname: K
authors.affiliation: Research Scholar, Department of Biochemistry, JIPMER , Pondicherry- 605 006, India .
authors.forename: P
authors.initials: P
authors.lastname: Sankar
authors.affiliation: Additional Professor, Department of Biochemistry, JIPMER , Pondicherry- 605 006, India .
authors.forename: Zachariah
authors.initials: Z
authors.lastname: Bobby
keywords: High fructose diet; Hypoglycemic; Hypolipidemic; S-methyl L-cysteine; Total antioxidant status