title: Bioavailability of two different formulations of coenzyme Q10 in healthy subjects.
abstract: The bioavailability of coenzyme Q10 (ubiquinone) formulated as an emulsion in a soft gelatin capsule (Ensorb(TM), NDS Pty Ltd, Sydney, Australia) was compared with a hard gelatin powder-filled capsule. The study design was a randomized cross-over trial with a 3-week wash-out period. The study population comprised 23 apparently healthy adults (12 men and 11 women), aged 20-43 years. Each participant took two 50 mg capsules, and blood samples were taken over a period of 36 h. The plasma concentration of coenzyme Q10 peaked between 3 and 4 h after administration of both preparations. The area under the curve (AUC) of Ensorb™ was 927% higher than that observed with the powder-filled capsule (P < 0.0001), suggesting that this emulsion preparation has a higher bioavailability.
authors.affiliation: Monash University, Department of Medicine, Australia.
authors.forename: M L
authors.initials: ML
authors.lastname: Wahlqvist
authors.forename: N
authors.initials: N
authors.lastname: Wattanapenpaiboon
authors.forename: G S
authors.initials: GS
authors.lastname: Savige
authors.forename: D
authors.initials: D
authors.lastname: Kannar