title: [The role of miRNAs in androgen-independent progression of prostate cancer].
abstract: MicroRNAs are a kind of small non-coding single-stranded RNA molecules that negatively regulate the gene expression by binding to imperfect complementary sites in the 3' untranslated region of targeted mRNAs at the post-transcriptional level. Aberrant expressions of some miRNAs like miR-221/222, miR-146a and miR-125b have been found to be significantly associated with androgen-independent progression of prostate cancer. By analyzing the aberrant expressions and regulation mechanisms of miRNAs in cell lines, tissues and peripheral blood samples, we hope to provide a new theoretic base for the clinical diagnosis and treatment of androgen-independent prostate cancer.
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Zhang
authors.affiliation: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Ning-Hong
authors.initials: NH
authors.lastname: Song
mesh_terms: D000728:Androgens / Q000494:pharmacology; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism
chemical_list: D000728:Androgens; D035683:MicroRNAs