title: Overexpression of Jazf1 reduces body weight gain and regulates lipid metabolism in high fat diet.
abstract: Jazf1 is a 27 kDa nuclear protein containing three putative zinc finger motifs that is associated with diabetes mellitus and prostate cancer; however, little is known about the role that this gene plays in regulation of metabolism. Recent evidence indicates that Jazf1 transcription factors bind to the nuclear orphan receptor TR4. This receptor regulates PEPCK, the key enzyme involved in gluconeogenesis. To elucidate Jazf1's role in metabolism, we fed a 60% fat diet for up to 15 weeks. In Jazf1 overexpression mice, weight gain was found to be significantly decreased. The expression of Jazf1 in the liver also suppressed lipid accumulation and decreased droplet size. These results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes.
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Woo Young
authors.initials: WY
authors.lastname: Jang
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Ki Beom
authors.initials: KB
authors.lastname: Bae
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Sung Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Yu
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Hei Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Young Rae
authors.initials: YR
authors.lastname: Ji
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Seo Jin
authors.initials: SJ
authors.lastname: Park
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Si Jun
authors.initials: SJ
authors.lastname: Park
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Min-Cheol
authors.initials: MC
authors.lastname: Kang
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Ja In
authors.initials: JI
authors.lastname: Jeong
authors.affiliation: College of Veterinary Medicine, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Sang-Joon
authors.initials: SJ
authors.lastname: Park
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea.
authors.forename: Sang Gyu
authors.initials: SG
authors.lastname: Lee
authors.affiliation: School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 700-842, Republic of Korea.
authors.forename: Inkyu
authors.initials: I
authors.lastname: Lee
authors.affiliation: School of Animal BT Sciences, Sangju Campus, Kyungpook National University, 386 Gajang-dong, Sangju, Gyeongsangbuk-do 742-211, Republic of Korea.
authors.forename: Myoung Ok
authors.initials: MO
authors.lastname: Kim
authors.affiliation: School of Animal BT Sciences, Sangju Campus, Kyungpook National University, 386 Gajang-dong, Sangju, Gyeongsangbuk-do 742-211, Republic of Korea. Electronic address: dhyoon@knu.ac.kr.
authors.forename: Duhak
authors.initials: D
authors.lastname: Yoon
authors.affiliation: School of Life Science and Biotechnology, Kyungpook National University, 1370 Sankyuk-dong, Buk-ku, Daegu 702-701, Republic of Korea. Electronic address: jaewoong64@hanmail.net.
authors.forename: Zae Young
authors.initials: ZY
authors.lastname: Ryoo
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002352:Carrier Proteins / Q000235:genetics*; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; D059305:Diet, High-Fat; D005951:Glucose Tolerance Test; D006706:Homeostasis; D007328:Insulin / Q000502:physiology; D050356:Lipid Metabolism / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D009687:Nuclear Proteins / Q000235:genetics*; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000037:antagonists & inhibitors / Q000378:metabolism; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015430:Weight Gain / Q000235:genetics*
chemical_list: D001786:Blood Glucose; D002352:Carrier Proteins; D056970:Co-Repressor Proteins; D004268:DNA-Binding Proteins; D007328:Insulin; C558308:JAZF1 protein, mouse; D009687:Nuclear Proteins; D010729:Phosphoenolpyruvate Carboxykinase (GTP)
keywords: Jazf1; Lipid accumulation; Obesity; PEPCK; TR4; Weight gain