title: An imbalance in the production of proinflammatory and anti-inflammatory cytokines is observed in whole blood cultures of preeclamptic women in comparison with healthy pregnant women.
abstract: OBJECTIVE
  To compare the production of pro- and anti-inflammatory cytokines by whole blood samples stimulated with lipopolysaccharide from normotensive and preeclamptic women.
  
  
  METHODS
  The synthesis of tumor necrosis factor-α, interleukyn-1β, interleukin-6 and interleukin-10 were assayed by immunosorbent assays in 56 and 50 preeclamptic and normotensive women, respectively.
  
  
  RESULTS
  Preeclamptic women showed a higher synthesis (p < 0.05) of interleukin-1β and interleukin-6 versus normotensive group. Interleukin-10 synthesis from samples of normotensive women showed a higher production versus preeclamptic group (p < 0.05).
  
  
  CONCLUSIONS
  Preeclamptic women showed an imbalance in the production of pro and anti-inflammatory cytokines in comparison with normotensive women.
authors.affiliation: Hospital Ángeles Acoxpa, Colonia Ex-Hacienda Coapa , México D.F. .
authors.forename: Jorge
authors.initials: J
authors.lastname: Campos-Cañas
authors.forename: Inés
authors.initials: I
authors.lastname: Romo-Palafox
authors.forename: Mario
authors.initials: M
authors.lastname: Albani-Campanario
authors.forename: César
authors.initials: C
authors.lastname: Hernández-Guerrero
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology; D011247:Pregnancy; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines