title: The reference genome sequence of Saccharomyces cerevisiae: then and now.
abstract: The genome of the budding yeast Saccharomyces cerevisiae was the first completely sequenced from a eukaryote. It was released in 1996 as the work of a worldwide effort of hundreds of researchers. In the time since, the yeast genome has been intensively studied by geneticists, molecular biologists, and computational scientists all over the world. Maintenance and annotation of the genome sequence have long been provided by the Saccharomyces Genome Database, one of the original model organism databases. To deepen our understanding of the eukaryotic genome, the S. cerevisiae strain S288C reference genome sequence was updated recently in its first major update since 1996. The new version, called "S288C 2010," was determined from a single yeast colony using modern sequencing technologies and serves as the anchor for further innovations in yeast genomic science.
authors.affiliation: Department of Genetics, Stanford University, Stanford, California 94305.
authors.forename: Stacia R
authors.initials: SR
authors.lastname: Engel
authors.forename: Fred S
authors.initials: FS
authors.lastname: Dietrich
authors.forename: Dianna G
authors.initials: DG
authors.lastname: Fisk
authors.forename: Gail
authors.initials: G
authors.lastname: Binkley
authors.forename: Rama
authors.initials: R
authors.lastname: Balakrishnan
authors.forename: Maria C
authors.initials: MC
authors.lastname: Costanzo
authors.forename: Selina S
authors.initials: SS
authors.lastname: Dwight
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Hitz
authors.forename: Kalpana
authors.initials: K
authors.lastname: Karra
authors.forename: Robert S
authors.initials: RS
authors.lastname: Nash
authors.forename: Shuai
authors.initials: S
authors.lastname: Weng
authors.forename: Edith D
authors.initials: ED
authors.lastname: Wong
authors.forename: Paul
authors.initials: P
authors.lastname: Lloyd
authors.forename: Marek S
authors.initials: MS
authors.lastname: Skrzypek
authors.forename: Stuart R
authors.initials: SR
authors.lastname: Miyasato
authors.forename: Matt
authors.initials: M
authors.lastname: Simison
authors.forename: J Michael
authors.initials: JM
authors.lastname: Cherry
mesh_terms: D002874:Chromosome Mapping; D016208:Databases, Factual; D016681:Genome, Fungal; D020407:Internet; D016366:Open Reading Frames; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014584:User-Computer Interface
keywords: S288C; Saccharomyces cerevisiae; genome release; model organism; reference sequence