title: Overexpression of S100P promotes colorectal cancer metastasis and decreases chemosensitivity to 5-FU in vitro.
abstract: S100P has been shown to be overexpressed in various cancers and to have putative involvement in the metastatic process. However, Clinical and pathological significance of S100P expression in colorectal cancer still needs to be further studied. In the present study, the method of immunohistochemistry was utilized to investigate S100P protein expression in 91 cases of colorectal cancer. Also, the influence of ectopic expression of S100P on the biologic behavior in SW480 colorectal cancer cells was studied. We found that S100P expression of colorectal cancer tissue was significantly higher than that of normal colorectal mucosal tissues. S100P expression showed to be significantly correlated with clinical staging, lymph node metastasis and recurrence. Ectopic expression of S100P promotes SW480 cancer cells migration and invasion, decreases chemosensitivity to 5-FU in vitro. These findings suggested that S100P could serve as a promising candidate for colorectal cancer marker, prognostic indicator, and therapeutic target.
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Fule
authors.initials: F
authors.lastname: Wang
authors.forename: Xiaona
authors.initials: X
authors.lastname: Yin
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Feiyan
authors.initials: F
authors.lastname: Lin
authors.forename: Wuhua
authors.initials: W
authors.lastname: Ni
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wu
authors.forename: Rong
authors.initials: R
authors.lastname: Jin
authors.forename: Lei
authors.initials: L
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D002135:Calcium-Binding Proteins / Q000235:genetics*; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects / Q000235:genetics; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008207:Lymphatic Metastasis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D009363:Neoplasm Proteins; C103003:S100P protein, human; D005472:Fluorouracil