title: Diastereoselective synthesis of dibenzoazepines through chelation on palladium(IV) intermediates.
abstract: Joint palladium/norbornene organometallic catalysis allows for straightforward access to dibenzo[c,e]azepines. These synthetically challenging polycyclic frameworks form in one pot via a three-component coupling of an aryl iodide, a bromobenzylamine, and an olefin. A key, atroposelective aryl-aryl coupling from chelated Pd(IV) intermediates dictates the outcome of the cascade. DFT modeling sheds light on the complex mechanism that allows the complete diasteroselectivity to be observed.
authors.affiliation: Institut de Chimie des Substances Naturelles, ICNS-CNRS , UPR 2301, Gif sur Yvette Cedex 91198, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Narbonne
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.forename: Giovanni
authors.initials: G
authors.lastname: Maestri
authors.forename: Max
authors.initials: M
authors.lastname: Malacria