title: Facile synthesis and intraparticle self-catalytic oxidation of dextran-coated hollow Au-Ag nanoshell and its application for chemo-thermotherapy.
abstract: Galvanic replacement reaction is a useful method to prepare various hollow nanostructures. We developed fast and facile preparation of biocompatible and structurally robust hollow Au-Ag nanostructures by using dextran-coated Ag nanoparticles. Oxidation of the surface dextran alcohols was enabled by catalytic activity of the core Au-Ag nanostructure, introducing carbonyl groups that are useful for further bioconjugation. Subsequent doxorubicin (Dox) conjugation via Schiff base formation was achieved, giving high payload of approximately 35 000 Dox per particle. Near-infrared-mediated photothermal conversion showed high efficacy of the Dox-loaded Au-Ag nanoshell as a combinational chemo-thermotherapy to treat cancer cells.
authors.affiliation: Center for RNA Research, Institute for Basic Science, Department of Chemistry, Seoul National University , Seoul 151-747, Republic of Korea.
authors.forename: Hongje
authors.initials: H
authors.lastname: Jang
authors.forename: Young-Kwan
authors.initials: YK
authors.lastname: Kim
authors.forename: Hyun
authors.initials: H
authors.lastname: Huh
authors.forename: Dal-Hee
authors.initials: DH
authors.lastname: Min
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002384:Catalysis; D003911:Dextrans / Q000737:chemistry*; D004317:Doxorubicin / Q000494:pharmacology*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D053768:Metal Nanoparticles; D010084:Oxidation-Reduction; D012834:Silver / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000903:Antibiotics, Antineoplastic; D003911:Dextrans; D012834:Silver; D006046:Gold; D004317:Doxorubicin