title: Grafting of GMA and some comonomers onto chitosan for controlled release of diclofenac sodium.
abstract: In order to develop pH sensitive hydrogels for controlled drug release we have graft copolymerized glycidyl methacrylate (GMA) with comonomers acrylic acid, acrylamide and acrylonitrile, onto chitosan (Ch) by using potassium persulphate (KPS) as free radical initiator in aqueous solution. The optimum percent grafting for GMA was recorded for 1g chitosan at [KPS]=25.00 × 10(-3)mol/L, [GMA]=0.756 × 10(-3)mol/L, reaction temperature=60 °C and reaction time=1h in 20 mL H2O. Binary monomers were grafted for five different concentrations at optimum grafting conditions evaluated for GMA alone onto chitosan. The graft copolymers were characterized by FTIR, XRD, TGA and SEM. The swelling properties of chitosan and graft copolymers were investigated at different pH to define their end uses in sustained release of an anti-inflammatory drug, diclofenac sodium. Percent drug release w.r.t. drug loaded in polymeric sample was studied as function of time in buffer solutions of pH 2.0 and 7.4. In vitro release data was analyzed using Fick's Law. Chitosan grafted with binary monomers, GMA-co-AAm and GMA-co-AN showed very good results for sustained release of drug at 7.4 pH.
authors.affiliation: Department of Chemistry, DAV College, Jalandhar, Punjab 144008, India. Electronic address: rksharma_75@yahoo.co.in.
authors.forename: Rajeev Kr
authors.initials: RK
authors.lastname: Sharma
authors.affiliation: Punjab Technical University, Jalandhar-Kapurthala Highway, Kapurthala, Punjab 144601, India.
authors.lastname: Lalita
authors.affiliation: Punjab Technical University, Jalandhar-Kapurthala Highway, Kapurthala, Punjab 144601, India.
authors.forename: Anirudh P
authors.initials: AP
authors.lastname: Singh
authors.affiliation: Himachal Pradesh University, Shimla 177005, India.
authors.forename: Ghanshyam S
authors.initials: GS
authors.lastname: Chauhan
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004852:Epoxy Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004852:Epoxy Compounds; D008689:Methacrylates; D011108:Polymers; D012997:Solvents; D004008:Diclofenac; D048271:Chitosan; C007870:glycidyl methacrylate
keywords: Binary monomers; Graft copolymerization; Swelling