title: The effects of aspirin and fish oil consumption on lysophosphatidylcholines and lysophosphatidic acids and their correlates with platelet aggregation in adults with diabetes mellitus.
abstract: Many diabetics are insensitive to aspirin's platelet anti-aggregation effects. The influence of co-administration of aspirin and fish oil (FO) on plasma lysophospholipids in subjects with diabetes is poorly characterized. Thirty adults with type 2 diabetes mellitus were treated with aspirin (81mg/day) for seven days, then with FO (4g/day) for 28 days, then in combination for another seven days. Lysophospholipids and platelet measures were determined after acute (4h) and chronic (7 days) ingestion of aspirin, FO, or both in combination. FO ingestion reduced all lysophosphatidic acid (LPA) concentrations, while EPA (20:5n-3) and DHA (22:6n-3) lysophosphatidylcholine (LPC) concentrations significantly increased after FO alone and in combination with aspirin. In vitro arachidonic acid-induced platelet aggregation was most strongly correlated with palmitoleic (16:1) and oleic (18:1) LPA and LPC concentrations at all time points. The ingestion of these agents may reduce cardiovascular disease risk in diabetic adults, with a disrupted lipid milieu, via lysolipid mediated mechanisms.
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.
authors.forename: Amir
authors.initials: A
authors.lastname: Abdolahi
authors.affiliation: Pulmonary and Critical Care Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.
authors.forename: Steve N
authors.initials: SN
authors.lastname: Georas
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States.
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Brenna
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States; Department of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.
authors.forename: Xueya
authors.initials: X
authors.lastname: Cai
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.
authors.forename: Kelly
authors.initials: K
authors.lastname: Thevenet-Morrison
authors.affiliation: Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Phipps
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States.
authors.forename: Peter
authors.initials: P
authors.lastname: Lawrence
authors.affiliation: Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, Albany, NY, United States.
authors.forename: Shaker A
authors.initials: SA
authors.lastname: Mousa
authors.affiliation: Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States. Electronic address: robert_block@urmc.rochester.edu.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Block
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D004435:Eating / Q000502:physiology; D005247:Feeding Behavior; D005260:Female; D005395:Fish Oils / Q000494:pharmacology*; D005399:Fishes; D006801:Humans; D008244:Lysophosphatidylcholines / Q000097:blood*; D008246:Lysophospholipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D005395:Fish Oils; D008244:Lysophosphatidylcholines; D008246:Lysophospholipids; D001241:Aspirin
keywords: Aspirin; Docosahexaenoic acid; Eicosapentaenoic acid; Lysophosphatidic acid; Lysophosphatidylcholine; Omega-3 fatty acids; Platelet function