title: Characterizing DNA methylation alterations from The Cancer Genome Atlas.
abstract: The Cancer Genome Atlas (TCGA) Research Network is an ambitious multi-institutional consortium effort aimed at characterizing sequence, copy number, gene (mRNA) expression, microRNA expression, and DNA methylation alterations in 30 cancer types. TCGA data have become an extraordinary resource for basic, translational, and clinical researchers and have the potential to shape cancer diagnostic and treatment strategies. DNA methylation changes are integral to all aspects of cancer genomics and have been shown to have important associations with gene expression, sequence, and copy number changes. This Review highlights the knowledge gained from DNA methylation alterations in human cancers from TCGA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Weisenberger
mesh_terms: D000818:Animals; D019313:BRCA1 Protein / Q000235:genetics; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000502:physiology; D045643:DNA Repair Enzymes / Q000502:physiology; D044127:Epigenesis, Genetic; D015894:Genome, Human; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics; D009154:Mutation; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000502:physiology
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D002843:Chromatin; D019941:Cyclin-Dependent Kinase Inhibitor p16; D025521:Tumor Suppressor Proteins; D007521:Isocitrate Dehydrogenase; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes