title: Vitamin C modulates lead excretion in rats.
abstract: Lead, one of the most toxic heavy metals, takes longer time to be excreted from the body than other heavy metals. The purpose of this study is, by measuring lead excretion via urine and feces, to find out the effect of vitamin C in lead chelation. Thirty-six rats were randomly assorted into four groups. All 33 rats except for the control group were administered with lead, before orally administered with different doses of vitamin C per kilogram of body weight. The lead excretion levels in urine and feces as well as the survival rate were then measured for each group. The rats with lead administrations (10/13, 76.9%) with lead administrations only, 10/11 rats (90.9%) with lead administrations and low dose of vitamin C, 9/9 rats (100%) with lead administrations and high dose of vitamin C survived. Among the 29 surviving rats, low vitamin C intake group exhibited higher urinary excretion than the lead only group. The urinary excretion level in high dose vitamin C intakegroup was significantly higher than the lead only group. In addition, fecal lead excretion seemed to be increased in the high dose vitamin C intake group, compared to the group with lead administrations only with statistical significance. Through animal experiment, it was found out that administrating high dose of vitamin C accelerated the excretion of lead in body compared to low dose of vitamin C.
authors.affiliation: Department of Family Medicine, Kosin University College of Medicine, Busan, Korea.
authors.forename: Hoseob
authors.initials: H
authors.lastname: Lihm
authors.affiliation: Department of Anatomy, Kosin University College of Medicine, Busan, Korea.
authors.forename: Hyun
authors.initials: H
authors.lastname: Kim
authors.affiliation: Department of Pathology, Kosin University College of Medicine, Busan, Korea.
authors.forename: Heekyung
authors.initials: H
authors.lastname: Chang
authors.affiliation: Department of Surgery, Kosin University College of Medicine, Busan, Korea.
authors.forename: Myunghee
authors.initials: M
authors.lastname: Yoon
authors.affiliation: Department of Family Medicine, Inje University College of Medicine, Busan, Korea.
authors.forename: Kayoung
authors.initials: K
authors.lastname: Lee
authors.affiliation: Department of Family Medicine, Kosin University College of Medicine, Busan, Korea.
authors.forename: Jongsoon
authors.initials: J
authors.lastname: Choi
keywords: Chelation; Excretion; Lead; Vitamin C