title: [Energy metabolism and glycemic metabolism in elderly people].
abstract: We here overviewed the current evidence for the clinical feature and the mechanistic insight of glucose intolerance in the elderly. Prevalence of glucose intolerance progressively increases in age, and postprandial hyperglycemia is a common feature of glucose intolerance in the elderly. Glucose intolerance in the elderly is associated both with impaired insulin secretion and insulin resistance. The change in the physical composition including sarcopenia and sarcopenic obesity is likely attributable to the development of insulin resistance observed in the elderly. Moreover, the dysfunction of mitochondria and the decline in the activity of certain hormones also appear to contribute to the pathogenesis of glucose intolerance in the elderly.
authors.affiliation: Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nakamura
authors.affiliation: Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine.
authors.forename: Yushi
authors.initials: Y
authors.lastname: Hirota
authors.affiliation: Division of Diabetes, Metabolism, and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine.
authors.forename: Wataru
authors.initials: W
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D004734:Energy Metabolism; D018149:Glucose Intolerance / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D000078790:Insulin Secretion; D008931:Mitochondria, Muscle / Q000502:physiology; D055948:Sarcopenia / Q000209:etiology
chemical_list: D012739:Gonadal Steroid Hormones; D007328:Insulin