title: Cardiovascular magnetic resonance in pregnancy: insights from the cardiac hemodynamic imaging and remodeling in pregnancy (CHIRP) study.
abstract: BACKGROUND
  Cardiovascular disease in pregnancy is the leading cause of maternal mortality in North America. Although transthoracic echocardiography (TTE) is the most widely used imaging modality for the assessment of cardiovascular function during pregnancy, little is known on the role of cardiovascular magnetic resonance (CMR). The objective of the Cardiac Hemodynamic Imaging and Remodeling in Pregnancy (CHIRP) study was to compare TTE and CMR in the non-invasive assessment of maternal cardiac remodeling during the peripartum period.
  
  
  METHODS
  Between 2010-2012, healthy pregnant women aged 18 to 35 years were prospectively enrolled. All women underwent TTE and CMR during the third trimester and at least 3 months postpartum (surrogate for non-pregnant state).
  
  
  RESULTS
  The study population included a total of 34 women (mean age 29 ± 3 years). During the third trimester, TTE and CMR demonstrated an increase in left ventricular end-diastolic volume from 95 ± 11 mL to 115 ± 14 mL and 98 ± 6 mL to 125 ± 5 mL, respectively (p<0.05). By TTE and CMR, there was also an increase in left ventricular (LV) mass during pregnancy from 111 ± 10 g to 163 ± 11 g and 121 ± 5 g to 179 ± 5 g, respectively (p<0.05). Although there was good correlation between both imaging modalities for LV mass, stroke volume, and cardiac output, the values were consistently underestimated by TTE.
  
  
  CONCLUSIONS
  This CMR study provides reference values for cardiac indices during normal pregnancy and the postpartum state.
authors.forename: Robin A
authors.initials: RA
authors.lastname: Ducas
authors.forename: Jason E
authors.initials: JE
authors.lastname: Elliott
authors.forename: Steven F
authors.initials: SF
authors.lastname: Melnyk
authors.forename: Sheena
authors.initials: S
authors.lastname: Premecz
authors.forename: Megan
authors.initials: M
authors.lastname: daSilva
authors.forename: Kelby
authors.initials: K
authors.lastname: Cleverley
authors.forename: Piotr
authors.initials: P
authors.lastname: Wtorek
authors.forename: G Scott
authors.initials: GS
authors.lastname: Mackenzie
authors.forename: Michael E
authors.initials: ME
authors.lastname: Helewa
authors.affiliation: Section of Cardiology, Department of Internal Medicine, Faculty of Medicine, University of Manitoba, Rm Y3531, Bergen Cardiac Care Centre, St, Boniface General Hospital, 409 Tache Avenue, Winnipeg, Manitoba R2H 2A6, Canada. djassal@sbgh.mb.ca.
authors.forename: Davinder S
authors.initials: DS
authors.lastname: Jassal
mesh_terms: D000293:Adolescent; D000328:Adult; D015150:Echocardiography, Doppler; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging; D015588:Observer Variation; D058725:Peripartum Period; D011237:Predictive Value of Tests; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D012016:Reference Values; D015203:Reproducibility of Results; D013318:Stroke Volume; D016277:Ventricular Function, Left; D016278:Ventricular Function, Right; D020257:Ventricular Remodeling; D055815:Young Adult