title: Angiosarcoma of the Breast with Solitary Metastasis to the Ovary during Pregnancy: An Uncommon Pattern of Metastatic Disease.
abstract: Primary de novo angiosarcoma of the breast is an uncommon, aggressive neoplasm. Here, we present a case of a young woman who initially developed primary angiosarcoma of the breast, and subsequently angiosarcoma of the ovary during pregnancy two years later. Only two confirmed primary angiosarcomas of the breast metastasizing specifically to the ovary have been described in the literature. However, all previous cases had ovarian metastases at presentation or shortly after initial diagnosis. This case is unusual as it occurred after a relatively long interval, and apparently developed during pregnancy. We discuss this rare phenomenon, as well as the possible factors contributing to the recurrence.
authors.affiliation: Sarcoma Unit, Royal Marsden Hospital, London SW3 6JJ, UK ; Department of Histopathology, Royal Marsden Hospital NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.
authors.forename: Jayson
authors.initials: J
authors.lastname: Wang
authors.affiliation: Sarcoma Unit, Royal Marsden Hospital, London SW3 6JJ, UK ; Department of Histopathology, Royal Marsden Hospital NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.
authors.forename: Cyril
authors.initials: C
authors.lastname: Fisher
authors.affiliation: Sarcoma Unit, Royal Marsden Hospital, London SW3 6JJ, UK ; Department of Histopathology, Royal Marsden Hospital NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, UK.
authors.forename: Khin
authors.initials: K
authors.lastname: Thway