title: Effective ablation therapy of adenomyosis with ultrasound-guided high-intensity focused ultrasound.
abstract: OBJECTIVE
  To evaluate the effects of ultrasound-guided high-intensity focused ultrasound (HIFU) on adenomyosis.
  
  
  METHODS
  In a retrospective analysis, data were reviewed from 202 patients with adenomyosis who underwent ultrasound-guided HIFU between November 2010 and June 2012 at Suining Central Hospital, Sichuan, China. Among these patients, 120 and 82 were classified as having focal adenomyosis and diffuse adenomyosis, respectively. All patients underwent pre-treatment and post-treatment magnetic resonance imaging by a standardized protocol to evaluate the treatment. All adverse effects were recorded.
  
  
  RESULTS
  All patients completed the ultrasound-guided HIFU treatment in 1 session. A non-perfused volume ratio of 71.6%±19.1% was achieved. Compared with baseline data, the average menorrhagia severity score and the average dysmenorrhea severity pain score decreased significantly after ultrasound-guided HIFU (both P<0.001). The proportion of women with complete relief of dysmenorrhea at the 3-month follow-up was significantly higher among women with focal adenomyosis than among those with diffuse adenomyosis (P=0.02). No other significant differences were observed between the 2 patient groups.
  
  
  CONCLUSIONS
  Ultrasound-guided HIFU was found to be an effective technique for treating both focal and diffuse adenomyotic lesions to alleviate the symptoms of menorrhagia or dysmenorrhea.
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Kequan
authors.initials: K
authors.lastname: Li
authors.affiliation: Department of Ultrasound, Huanggang Central Hospital, Hubei, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Xie
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Min
authors.initials: M
authors.lastname: He
authors.affiliation: Department of Obstetrics and Gynecology, Suining Central Hospital, Sichuan, China.
authors.forename: Jia
authors.initials: J
authors.lastname: He
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China. Electronic address: lianwzhang@yahoo.com.
authors.forename: Lian
authors.initials: L
authors.lastname: Zhang
mesh_terms: D062788:Adenomyosis / Q000473:pathology / Q000601:surgery*; D000328:Adult; D002681:China; D004412:Dysmenorrhea / Q000209:etiology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D057086:High-Intensity Focused Ultrasound Ablation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008595:Menorrhagia / Q000209:etiology / Q000601:surgery*; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*
keywords: Adenomyosis; Diffuse adenomyosis; Focal adenomyosis; Ultrasound-guided high-intensity focused ultrasound