title: The prognostic value of interim positron emission tomography scan in patients with classical Hodgkin lymphoma.
abstract: The prognostic value of interim positron emission tomography (PET) was evaluated after 2 cycles of doxorubicin, bleomycin, vinblastin and dacarbazine in classical Hodgkin lymphoma patients (n = 229), based on Deauville criteria. In early stage non-bulky disease, bulky stage II disease, advanced stage low International Prognostic Score (IPS ≤2) and advanced stage (IPS ≥3), 3-year progression-free survival rates in PET2-negative vs. PET2-positive groups were 95·9% vs. 76·9% (P < 0·0018), 83·3% vs. 20·0% (P = 0·017), 77·0% vs. 30·0% (P < 0·001) and 71·0% vs. 44·4%(P = 0·155), respectively. The outcome after positive PET2 was better than previously reported. The results from non-randomized studies of PET2-guided therapy would be valuable with careful interpretation.
authors.affiliation: Department of Lymphoma/Myeloma, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Oki
authors.forename: Hubert
authors.initials: H
authors.lastname: Chuang
authors.forename: Beth
authors.initials: B
authors.lastname: Chasen
authors.forename: Aaron
authors.initials: A
authors.lastname: Jessop
authors.forename: Tinsu
authors.initials: T
authors.lastname: Pan
authors.forename: Michelle
authors.initials: M
authors.lastname: Fanale
authors.forename: Bouthaina
authors.initials: B
authors.lastname: Dabaja
authors.forename: Nathan
authors.initials: N
authors.lastname: Fowler
authors.forename: Jorge
authors.initials: J
authors.lastname: Romaguera
authors.forename: Luis
authors.initials: L
authors.lastname: Fayad
authors.forename: Fredrick
authors.initials: F
authors.lastname: Hagemeister
authors.forename: Maria Alma
authors.initials: MA
authors.lastname: Rodriguez
authors.forename: Sattva
authors.initials: S
authors.lastname: Neelapu
authors.forename: Felipe
authors.initials: F
authors.lastname: Samaniego
authors.forename: Larry
authors.initials: L
authors.lastname: Kwak
authors.forename: Anas
authors.initials: A
authors.lastname: Younes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D016016:Proportional Hazards Models; D055815:Young Adult
keywords: Hodgkin lymphoma; positron emission tomography; prognostic