title: [A case of gastric cancer accompanied by disseminated carcinomatosis of the bone marrow successfully controlled by S-1 and cisplatin combination therapy].
abstract: We report a case of gastric cancer accompanied by disseminated carcinomatosis of the bone marrow treated with S-1 and cisplatin( CDDP) combination chemotherapy. The patient was a 68-year-old woman who was detected as having disseminated intravascular coagulation( DIC) during an examination for gastric cancer and she was diagnosed as having disseminated carcinomatosis of the bone marrow by lumbar puncture. She was immediately treated with S-1 and CDDP combination chemotherapy( S-1, 80 mg/body orally administered[ po] on days 1-21 and CDDP, 60 mg/body intravenously [iv] administered on day 8) and her DIC improved on the fourth day. Subsequently, the patient was treated with 3 courses of combination chemotherapy and she survived for 184 days from the initiation of the treatment. Although disseminated carcinomatosis of the bone marrow is associated with a poor prognosis, we believe that the duration of survival of our patient was extended due to initiation of chemotherapy at an early stage.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Health and Medical Treatment Corporation Toshima Hospital.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ganno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagahama
authors.forename: Akira
authors.initials: A
authors.lastname: Fukuda
authors.forename: Shoko
authors.initials: S
authors.lastname: Takeuchi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiya
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Amagasa
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kamikozuru
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Imai
authors.forename: Katsunori
authors.initials: K
authors.lastname: Ami
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Aoki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ando
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Arai
authors.forename: Shikofumi
authors.initials: S
authors.lastname: Tei
authors.forename: Masahide
authors.initials: M
authors.lastname: Ohbu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D019046:Bone Marrow Neoplasms / Q000188:drug therapy* / Q000556:secondary; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D004338:Drug Combinations; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin