title: Endoplasmic reticulum stress and angiogenesis: is there an interaction between them?
abstract: When cells are subjected to stress by changes in their extracellular environment, unfolded proteins accumulate in the endoplasmic reticulum (ER), causing ER stress. This initiates the unfolded protein response (UPR), a signal transduction cascade aiming at restoring cellular homeostasis. The UPR and angiogenesis are involved in the pathogenesis of many diseases such as cancer, pulmonary diseases and chronic liver diseases (CLDs) including alcoholic liver disease, non-alcoholic steatohepatitis and hepatitis B. This review summarizes the upcoming knowledge of the interaction between the UPR and angiogenesis in physiological angiogenesis and in different CLDs and other diseases.
authors.affiliation: Department of Gastroenterology and Hepatology, Ghent University, Ghent, Belgium.
authors.forename: Annelies
authors.initials: A
authors.lastname: Paridaens
authors.forename: Debby
authors.initials: D
authors.lastname: Laukens
authors.forename: Yves-Paul
authors.initials: YP
authors.lastname: Vandewynckel
authors.forename: Stephanie
authors.initials: S
authors.lastname: Coulon
authors.forename: Hans
authors.initials: H
authors.lastname: Van Vlierberghe
authors.forename: Anja
authors.initials: A
authors.lastname: Geerts
authors.forename: Isabelle
authors.initials: I
authors.lastname: Colle
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000473:pathology; D059865:Endoplasmic Reticulum Stress; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008099:Liver / Q000098:blood supply* / Q000378:metabolism* / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D015398:Signal Transduction; D056811:Unfolded Protein Response
chemical_list: D047908:Intracellular Signaling Peptides and Proteins
keywords: angiogenesis; cirrhosis; endoplasmic reticulum stress; liver diseases; unfolded protein response; vascular endothelial growth factor A