title: In and out of the bone: can the osteocyte escape skeletal jail and yet regulate mineralization?
abstract: An increase in the levels of fibroblast growth factor 23 (FGF23) develops in the early phase of chronic kidney disease (CKD). However, the initial trigger of CKD-mineral and bone disorder (CKD-MBD) is a matter of debate. Fang and associates provide evidence, in a mouse model of early CKD, that osteocytes and osteocyte-like cells play an important role at the earliest stage of CKD-MBD. The osteocytes may become a target of intervention in CKD-MBD.
authors.affiliation: Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Junichiro J
authors.initials: JJ
authors.lastname: Kazama
authors.affiliation: Division of Nephrology, Endocrinology, and Metabolism, Tokai University School of Medicine, Isehara, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fukagawa
mesh_terms: D000818:Animals; D001851:Bone Diseases, Metabolic / Q000503:physiopathology*; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000096:biosynthesis*; D005966:Glucuronidase / Q000097:blood*; D000090265:Klotho Proteins; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000503:physiopathology*; D061205:Vascular Calcification
chemical_list: C000717428:Fgf23 protein, mouse; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins