title: Congenital granular cell epulis.
abstract: Congenital granular cell epulis is a rarely reported lesion of unknown histogenesis with a strong predilection for the maxillary alveolar ridge of newborn girls. Microscopically, it demonstrates nests of polygonal cells with granular cytoplasm, a prominent capillary network, and attenuated overlying squamous epithelium. The lesion lacks immunoreactivity for S-100, laminin, chromogranin, and most other markers except neuron-specific enolase and vimentin. Through careful observation of its unique clinical, histopathologic, and immunohistochemical features, this lesion can be distinguished from the more common adult granular cell tumor as well as other differential diagnoses.
authors.affiliation: From the Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, California.
authors.forename: Rachel
authors.initials: R
authors.lastname: Conrad
authors.forename: Mia C N
authors.initials: MC
authors.lastname: Perez
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D005887:Gingival Neoplasms / Q000151:congenital* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007231:Infant, Newborn; D008297:Male
chemical_list: D014408:Biomarkers, Tumor