title: Comparative analysis of the incidence of surgical site infections in patients with liver resection for colorectal hepatic metastases after neoadjuvant chemotherapy.
abstract: BACKGROUND
  The aim of this study was to identify the incidence of surgical site infections (SSIs) and postoperative complications, as defined by the Clavien-Dindo classification, after hepatic resection for metastatic colorectal cancer in patients with and without associated neoadjuvant chemotherapy.
  
  
  METHODS
  A total of 181 patients were studied retrospectively. Patients were divided into two groups: the first group comprised patients with associated neoadjuvant chemotherapeutic treatment for liver metastases with a latency time <8 wk and the second group comprised patients without associated neoadjuvant chemotherapy.
  
  
  RESULTS
  Variables of duration of liver surgery, length of total hospital stay, and length of postoperative hospital stay seem to be correlated with SSIs and postoperative complications, P < 0.005 and P < 0.0001, respectively. Duration of surgery is a risk factor for SSIs, with an odds ratio of 1.15, and for complications according to the Clavien-Dindo classification, with an odds ratio of 1.35.
  
  
  CONCLUSIONS
  Neoadjuvant chemotherapy was not a significant risk factor for SSIs, whereas the total length of hospital stay, length of postoperative hospital stay, and duration of surgery were independent predictors of SSIs and complications according to the Clavien-Dindo classification.
authors.affiliation: Department of Surgical Sciences, University of Catania, Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele, Catania, Italy. Electronic address: robertoscilletta@gmail.com.
authors.forename: Roberto
authors.initials: R
authors.lastname: Scilletta
authors.affiliation: Department of Surgery, University of Pittsburgh, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center in Italy, Palermo, Italy.
authors.forename: Duilio
authors.initials: D
authors.lastname: Pagano
authors.affiliation: Department of Surgery, University of Pittsburgh, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center in Italy, Palermo, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Spada
authors.affiliation: Department of Abdominal Oncology Surgery, Humanitas Centro Catanese di Oncologia, Catania, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Mongiovì
authors.affiliation: Department of Surgical Sciences, University of Catania, Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele, Catania, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Pesce
authors.affiliation: Department of Surgical Sciences, University of Catania, Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele, Catania, Italy.
authors.forename: Teresa R
authors.initials: TR
authors.lastname: Portale
authors.affiliation: Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele, Catania, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Guardabasso
authors.affiliation: Department of Surgical Sciences, University of Catania, Azienda Ospedaliero - Universitaria Policlinico - Vittorio Emanuele, Catania, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Puleo
authors.affiliation: Department of Surgery, University of Pittsburgh, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT), University of Pittsburgh Medical Center in Italy, Palermo, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gruttadauria
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology*
chemical_list: D000970:Antineoplastic Agents
keywords: Clavien–Dindo classification; Colorectal liver metastases; Liver surgery; Neoadjuvant chemotherapy; Risk factors; Surgical site infection