title: AKI with serious state of acidosis in diabetic patients treated with metformin.
abstract: Metformin is a drug increasingly used in the treatment of diabetic patients. In addition to its hypoglycemic effect, it reduces vascular risk and does not determine an increase in body weight. Compared to the older molecule, phenformin, metformin possesses a lower risk of induction of severe lactic acidosis in the general diabetic population. On the other hand, metformin must be used with caution in patients with kidney damage. In patients with a glomerular filtration rate (GFR) below 30 ml/min, the use of metformin is also associated with a high risk of lactic acidosis. The assessment of glomerular filtration rate using MDRD or CKD-EPI formulas allows the clinician to identify patients potentially at risk. All subjects with normal renal function treated with metformin for years are at risk of suddenly developing lactic acidosis during episodes of acute worsening renal function. We report a case of lactic acidosis in association with acute kidney injury (AKI).
authors.forename: Filippo
authors.initials: F
authors.lastname: Girasole
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Piccolo
authors.forename: Roberto
authors.initials: R
authors.lastname: Timpanelli
authors.forename: Massimo
authors.initials: M
authors.lastname: Calanna
authors.forename: Francesca
authors.initials: F
authors.lastname: Piazza
authors.forename: Sarah
authors.initials: S
authors.lastname: Vecchio
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008687:Metformin / Q000009:adverse effects*; D012720:Severity of Illness Index
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin