title: Interaction of toxin-1 and T lymphocytes in toxic shock syndrome.
abstract: Toxic shock syndrome (TSS) is a potentially fatal illness caused by infection with the bacterium Staphylococcus aureus. TSS toxin-1 (TSST-1) contains a T-cell epitope with specificity for human V-beta-2. Binding of TSST-1 to the human major histocompatibility complex and T cell receptors activates T cells and triggers the secretion of high amounts of inflammatory cytokines, leading to TSS and potentially death. During this process, CD4+ T cells are inhibited by TSST-1, while regulatory T cells are increased. This suggests a protective immune response by the body in TSS. Thus, TSST-1 can trigger both, an inflammatory response that attacks the body and a protective response. In this review, we discuss the interaction between TSST-1 and T lymphocytes in TSS.
authors.affiliation: Department of emergency medicine, Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou , China.
authors.forename: De
authors.initials: D
authors.lastname: Kang
authors.affiliation: Affiliated Dongnan Hospital of Xiamen University School of Medicine, Zhangzhou, China.
authors.forename: Cun-he
authors.initials: CH
authors.lastname: Lin
authors.affiliation: Department of emergency medicine, Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou , China.
authors.forename: Guixi
authors.initials: G
authors.lastname: Chen
authors.affiliation: Department of emergency medicine, Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou , China.
authors.forename: Shou-gui
authors.initials: SG
authors.lastname: Guo
authors.affiliation: Department of emergency medicine, Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou , China.
authors.forename: Yan-sheng
authors.initials: YS
authors.lastname: Wu
authors.affiliation: Department of emergency medicine, Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou , China.
authors.forename: Zhi-peng
authors.initials: ZP
authors.lastname: Zheng
authors.affiliation: Department of emergency medicine, Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou , China.
authors.forename: Cong-hui
authors.initials: CH
authors.lastname: Shi
authors.affiliation: Department of emergency medicine, Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou , China.
authors.forename: Gong-lei
authors.initials: GL
authors.lastname: Chen
authors.affiliation: Department of emergency medicine, Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou , China.
authors.forename: Xu
authors.initials: X
authors.lastname: Ji
mesh_terms: D001427:Bacterial Toxins / Q000276:immunology*; D001665:Binding Sites; D006801:Humans; D016131:Lymphocyte Subsets; D012772:Shock, Septic / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D001427:Bacterial Toxins