title: Association of BSG genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population.
abstract: The Basigin (BSG, also known as CD147/extracellular matrix metalloproteinase inducer) belongs to the immunoglobulin superfamily (IgSF). It is a cellular receptor for cyclophilin A (CypA), and is originally known as tumor cell collagenase stimulatory factor (TCSF), which could abundantly expressed on the surface of tumor cells, haematopoietic, monocytes, epithelial endothelial cells and smooth muscle cells. Accumulating evidence showed that BSG played an important role in stimulating the secretion of matrix metalloproteinases (MMPs), which has been reported to be involved in the development of atherosclerosis. Since atherosclerosis is an important risk factor for atherosclerotic cerebral infarction (ACI), we speculate that BSG genetic polymorphisms may influence formation of atherosclerosis and then development of ACI. This study aimed to detect the potential association of the single nucleotide polymorphisms (SNP, -631 G > T, -318 G > C, 10141 G > A and 10826 G > A) of BSG gene in Hunan Han Chinese population with ACI. We genotyped 199 ACI patients and 188 matched healthy controls for the four BSG SNP by method of matrix-assisted laser desorption/ionization-time-offlight mass spectrometry (MALDI-TOF MS). Our results suggested that all the polymorphisms were observed in the subjects from Changsha area of Hunan Province. However, no significant difference was observed between the distribution of these SNP in cases and controls. Therefore, we speculate that BSG genetic polymorphisms might not be an important factor in the development of ACI in our Chinese Han population.
authors.affiliation: Institute of Neurology, Xiangya Hospital, Central South University , Changsha, Hunan , China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.forename: Bingxin
authors.initials: B
authors.lastname: Song
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Duan
authors.forename: Yuming
authors.initials: Y
authors.lastname: Long
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Lu
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Li
authors.forename: Sian
authors.initials: S
authors.lastname: Zeng
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhan
authors.forename: Mei
authors.initials: M
authors.lastname: Yuan
authors.forename: Qidong
authors.initials: Q
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Xia
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D051926:Basigin / Q000235:genetics*; D002544:Cerebral Infarction / Q000209:etiology* / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C497886:BSG protein, human; D051926:Basigin
keywords: BSG gene; atherosclerosis; cerebral infarction; single nucleotide polymorphisms