title: High-performance liquid chromatographic enantioseparation of racemic drugs based on homochiral metal-organic framework.
abstract: Homochiral metal-organic frameworks with fine-tuned pore sizes/walls and large surface areas are promising porous materials for enantioseparation considering the traditional zeolite molecular sieves have no chirality. Using enantiopure pyridyl-functionalized salen [(N-(4-Pyridylmethyl)-L-leucine·HBr)] as a starting material, we have prepared a noninterpenetrated three-dimensional homochiral metal organic framework {[ZnLBr]·H2O}n, which was further used as a chiral stationary phase for high-performance liquid chromatography to enantioseparate racemic drugs, showing excellent performances in enantioseparation of drugs. The metal-organic framework can be regarded as a novel molecular sieve-like material with a chiral separation function based on the relative sizes of the chiral channels and the resolved molecules.
authors.affiliation: College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University , Jinan 250014, People's Republic of China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Kuang
authors.forename: Yu
authors.initials: Y
authors.lastname: Ma
authors.forename: Hao
authors.initials: H
authors.lastname: Su
authors.forename: Jine
authors.initials: J
authors.lastname: Zhang
authors.forename: Yu-Bin
authors.initials: YB
authors.lastname: Dong
authors.forename: Bo
authors.initials: B
authors.lastname: Tang
mesh_terms: D001573:Benzoin / Q000302:isolation & purification*; D001592:Benzyl Alcohols / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D005029:Ethylenediamines / Q000737:chemistry; D007052:Ibuprofen / Q000302:isolation & purification*; D007660:Ketoprofen / Q000302:isolation & purification*; D009288:Naproxen / Q000302:isolation & purification*; D016062:Porosity; D011725:Pyridines / Q000737:chemistry; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry
chemical_list: D001592:Benzyl Alcohols; D056831:Coordination Complexes; D005029:Ethylenediamines; D011725:Pyridines; C020488:4-pyridylmethyl; D009288:Naproxen; D007660:Ketoprofen; C007656:alpha-ethylbenzyl alcohol; C011452:disalicylaldehyde ethylenediamine; D015032:Zinc; D001573:Benzoin; D007052:Ibuprofen