title: Complete sequence of a KPC-producing IncN multidrug-resistant plasmid from an epidemic Escherichia coli sequence type 131 strain in China.
abstract: We report here the nucleotide sequence of a novel blaKPC-2-harboring incompatibility group N (IncN) plasmid, pECN580, from a multidrug-resistant Escherichia coli sequence type 131 (ST131) isolate recovered from Beijing, China. pECN580 harbors β-lactam resistance genes blaKPC-2, blaCTX-M-3, and blaTEM-1; aminoglycoside acetyltransferase gene aac(6')-Ib-cr; quinolone resistance gene qnrS1; rifampin resistance gene arr-3; and trimethoprim resistance gene dfrA14. The emergence of a blaKPC-2-harboring multidrug-resistant plasmid in an epidemic E. coli ST131 clone poses a significant potential threat in community and hospital settings.
authors.affiliation: Public Health Research Institute TB Center, NJMS-Rutgers University, Newark, New Jersey, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Hongyan
authors.initials: H
authors.lastname: Hu
authors.forename: Kalyan D
authors.initials: KD
authors.lastname: Chavda
authors.forename: Shulong
authors.initials: S
authors.lastname: Zhao
authors.forename: Renkun
authors.initials: R
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Liang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Xiumei
authors.initials: X
authors.lastname: Wang
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: Robert A
authors.initials: RA
authors.lastname: Bonomo
authors.forename: Barry N
authors.initials: BN
authors.lastname: Kreiswirth
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002681:China; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics*; D015363:Quinolones / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones; D014295:Trimethoprim; D012293:Rifampin