title: [A case of consciousness disorder induced by the syndrome of inappropriate secretion of antidiuretic hormone following cisplatin and 5-fluorouracil chemotherapy in a patient with esophageal cancer].
abstract: We report a case of consciousness disorder following the fourth course of chemotherapy with cisplatin (CDDP) and 5- fluorouracil (5-FU) in a patient with esophageal cancer. A 74-year-old man was admitted to our hospital to receive chemotherapy for esophageal cancer. Six days after chemotherapy, the patient showed impaired consciousness and his serum sodium concentration was found to be 125 mEq/L, but no edema or dehydration was noted. This hyponatremic state was diagnosed as CDDP-induced syndrome of inappropriate secretion of antidiuretic hormone (SIADH) on the basis of serum and urine hypo-osmolality. Accordingly, fluid intake was restricted and sodium supplements were administered, resulting in an appropriate increase in the serum sodium concentration to 132 mEq/L in 4 days.
authors.affiliation: Dept. of Surgery, Yokosuka Kyosai Hospital.
authors.forename: Chiho
authors.initials: C
authors.lastname: Endo
authors.forename: Ryo
authors.initials: R
authors.lastname: Takagawa
authors.forename: Tsukuru
authors.initials: T
authors.lastname: Chiba
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Konishi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Honma
authors.forename: Yuta
authors.initials: Y
authors.lastname: Minami
authors.forename: Jun
authors.initials: J
authors.lastname: Watanabe
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Morita
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Mogaki
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Masui
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003244:Consciousness Disorders / Q000188:drug therapy / Q000209:etiology*; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D012964:Sodium / Q000627:therapeutic use
chemical_list: D012964:Sodium; D002945:Cisplatin; D005472:Fluorouracil