title: MicroRNAs affect BCL-2 family proteins in the setting of cerebral ischemia.
abstract: The BCL-2 family is centrally involved in the mechanism of cell death after cerebral ischemia. It is well known that the proteins of the BCL-2 family are key regulators of apoptosis through controlling mitochondrial outer membrane permeabilization. Recent findings suggest that many BCL-2 family members are also directly involved in controlling transmission of Ca(2+) from the endoplasmic reticulum (ER) to mitochondria through a specialization called the mitochondria-associated ER membrane (MAM). Increasing evidence supports the involvement of microRNAs (miRNAs), some of them targeting BCL-2 family proteins, in the regulation of cerebral ischemia. In this mini-review, after highlighting current knowledge about the multiple functions of BCL-2 family proteins and summarizing their relationship to outcome from cerebral ischemia, we focus on the regulation of BCL-2 family proteins by miRNAs, especially miR-29 which targets multiple BCL-2 family proteins.
authors.affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: ybouyang@stanford.edu.
authors.forename: Yi-Bing
authors.initials: YB
authors.lastname: Ouyang
authors.affiliation: Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: rona.giffard@stanford.edu.
authors.forename: Rona G
authors.initials: RG
authors.lastname: Giffard
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002545:Brain Ischemia / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D019254:Genes, bcl-2 / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008969:Molecular Sequence Data; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics*
chemical_list: D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2
keywords: BCL-2; Cerebral ischemia; Stroke; miR-29; microRNA