title: The BAG2 protein stabilises PINK1 by decreasing its ubiquitination.
abstract: Mutations in the PTEN-induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). Thus far, little is known about what can regulate the ubiquitin proteasome pathway of PINK1. Here, we report BAG2 (Bcl-2-associated athanogene family protein 2), a member of the BAG family, which directly binds with and stabilises PINK1 by decreasing its ubiquitination. Moreover, we found that BAG2 also binds with the pathogenic R492X PINK1 mutation directly and more tightly. Moreover, BAG2 stabilises the R492X PINK1 mutation by decreasing its ubiquitination to a greater extent than the wild-type species. Our data correlate BAG2 to PINK1 for the first time, strengthening the important role of BAG2 in PD-related neurodegeneration.
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Che
authors.forename: Beisha
authors.initials: B
authors.lastname: Tang
authors.forename: Xuejing
authors.initials: X
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Chen
authors.forename: Xinxiang
authors.initials: X
authors.lastname: Yan
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Lu
authors.initials: L
authors.lastname: Shen
authors.forename: Qian
authors.initials: Q
authors.lastname: Xu
authors.forename: Guanghui
authors.initials: G
authors.lastname: Wang
authors.forename: Jifeng
authors.initials: J
authors.lastname: Guo
mesh_terms: D004795:Enzyme Stability; D057809:HEK293 Cells; D006801:Humans; D047468:Immunoprecipitation; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D010300:Parkinson Disease / Q000378:metabolism*; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination; D000099202:PTEN-Induced Putative Kinase
chemical_list: D018832:Molecular Chaperones; D011494:Protein Kinases; D000099202:PTEN-Induced Putative Kinase; C492980:BAG2 protein, human