title: Therapeutic targeting of EPH receptors and their ligands.
abstract: Critical roles for EPH receptor (EPH)-ephrin signalling in a range of chronic and regenerative diseases are increasingly being recognized. In particular, the complex roles of EPHs and ephrins in tumour growth and progression, and in nerve injury and regeneration have been studied extensively. This has led to considerable progress in developing strategies for their therapeutic targeting, with some anticancer agents already in clinical trials. Promising leads for non-malignant diseases are also emerging, with compelling preclinical data encouraging clinical development. We discuss this rapidly developing area of drug discovery, highlighting the associated challenges and limitations.
authors.affiliation: Leukaemia Foundation Research Laboratory, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Boyd
authors.affiliation: Queensland Brain Institute, University of Queensland, Brisbane, Queensland 4072, Australia.
authors.forename: Perry F
authors.initials: PF
authors.lastname: Bartlett
authors.affiliation: Department of Biochemistry and Molecular Biology, Monash University, Victoria 3800, Australia.
authors.forename: Martin
authors.initials: M
authors.lastname: Lackmann
mesh_terms: D036342:Ephrins / Q000502:physiology* / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D008954:Models, Biological; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D009422:Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology; D036081:Receptors, Eph Family / Q000502:physiology*; D012038:Regeneration / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
chemical_list: D036342:Ephrins; D036081:Receptors, Eph Family