title: Over-expression of the overexpressed in lung cancer-1 is associated with poor prognosis in colorectal cancer.
abstract: OBJECTIVE
  The overexpressed in lung cancer-1 (OLC1) protein is overexpressed in a variety of human tumors. The purpose of the present study was to determine whether increased expression of OLC1 is associated with colorectal cancer.
  
  
  METHODS
  OLC1 expression was assayed in 150 colorectal cancer tissues by immunohistochemical staining (IHC). Multivariate and univariate analyses were performed to determine the association between OLC1 expression and prognosis.
  
  
  RESULTS
  Immunohistochemical results revealed that 107 out of 150 colorectal cancer patients had increased levels of OLC1. OLC1 expression was significantly correlated with UICC stage (p<0.001) and histological differentiation (p<0.001) in colorectal cancer patients. The 5-year overall survival (OS) rates in patients with strong-positive and weak OLC1 staining were 16.6% and 95.3%, respectively (p<0.0001).
  
  
  CONCLUSIONS
  OLC1 overexpression is an important factor in colorectal carcinoma prognosis and can be an interesting potential novel biomarker for colorectal cancer.
authors.affiliation: Department of Medical Oncology, The Third Affiliated Hospital of Harbin Medical University, 150081 Harbin, China. wyyd1962@126.com.
authors.forename: Jinglei
authors.initials: J
authors.lastname: Liu
authors.forename: Hongtao
authors.initials: H
authors.lastname: Song
authors.forename: Lei
authors.initials: L
authors.lastname: Yao
authors.forename: Yanlong
authors.initials: Y
authors.lastname: Liu
authors.forename: Youxue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhao
authors.forename: Hongfei
authors.initials: H
authors.lastname: Ji
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D003106:Colon / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015513:Oncogene Proteins / Q000378:metabolism*; D011379:Prognosis; D012007:Rectum / Q000378:metabolism; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C533705:IST1 protein, human; D015513:Oncogene Proteins
keywords: Overexpressed in lung cancer 1 (OLC1); colorectal cancer; immunohistochemistry; prognosis