title: Neurological disorders in a murine model of chronic renal failure.
abstract: Cardiovascular disease is highly prevalent in patients with chronic renal failure (CRF). However, data on the impact of CRF on the cerebral circulatory system are scarce-despite the fact that stroke is the third most common cause of cardiovascular death in people with CRF. In the present study, we examined the impact of CRF on behavior (anxiety), recognition and ischemic stroke severity in a well-defined murine model of CRF. We did not observe any significant increases between CRF mice and non-CRF mice in terms of anxiety. In contrast, CRF mice showed lower levels of anxiety in some tests. Recognition was not impaired (vs. controls) after 6 weeks of CRF but was impaired after 10 weeks of CRF. Chronic renal failure enhances the severity of ischemic stroke, as evaluated by the infarct volume size in CRF mice after 34 weeks of CRF. Furthermore, neurological test results in non-CRF mice tended to improve in the days following ischemic stroke, whereas the results in CRF mice tended to worsen. In conclusion, we showed that a murine model of CRF is suitable for evaluating uremic toxicity and the associated neurological disorders. Our data confirm the role of uremic toxicity in the genesis of neurological abnormalities (other than anxiety).
authors.affiliation: INSERM U1088, UFR de Pharmacie, 1 rue des Louvels, F-80037 Amiens cedex 1, France. jean-marc.chillon@u-picardie.fr.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Chillon
authors.affiliation: INSERM U1088, UFR de Pharmacie, 1 rue des Louvels, F-80037 Amiens cedex 1, France. francois.brazier@hotmail.fr.
authors.forename: François
authors.initials: F
authors.lastname: Brazier
authors.affiliation: INSERM U1088, UFR de Pharmacie, 1 rue des Louvels, F-80037 Amiens cedex 1, France. philippe.bouquet@u-picardie.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Bouquet
authors.affiliation: INSERM U1088, UFR de Pharmacie, 1 rue des Louvels, F-80037 Amiens cedex 1, France. massy@u-picardie.fr.
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Massy
mesh_terms: D000818:Animals; D001007:Anxiety; D001522:Behavior, Animal; D004195:Disease Models, Animal; D005260:Female; D007676:Kidney Failure, Chronic / Q000150:complications / Q000473:pathology*; D018782:Maze Learning; D051379:Mice; D008810:Mice, Inbred C57BL; D009422:Nervous System Diseases / Q000209:etiology / Q000473:pathology*; D020521:Stroke / Q000209:etiology / Q000473:pathology; D014511:Uremia