title: [Patient with acute renal injury presenting dabigatran overdose: Hemodialysis for surgery].
abstract: Dabigatran is a direct thrombin inhibitor indicated for stroke and systemic embolism prevention in patients with non-valvular atrial fibrillation. No reversal agent exists, but hemodialysis has been proposed as dabigatran removal method. We report a case of an 80-year-old man presenting hemorrhage with dabigatran overdose caused by obstructive acute renal failure. Before nephrostomy, several hemodialysis sessions were necessary to remove dabigatran probably because of its large volume of distribution.
authors.affiliation: Pôle d'anesthésie réanimation, hôpital de Rangueil, 31059 Toulouse cedex 9, France.
authors.forename: B
authors.initials: B
authors.lastname: Bachellerie
authors.affiliation: Pôle d'anesthésie réanimation, hôpital de Rangueil, 31059 Toulouse cedex 9, France. Electronic address: ruiz.stephanie@chu-toulouse.fr.
authors.forename: S
authors.initials: S
authors.lastname: Ruiz
authors.affiliation: Pôle d'anesthésie réanimation, hôpital de Rangueil, 31059 Toulouse cedex 9, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Conil
authors.affiliation: Pôle d'anesthésie réanimation, hôpital de Rangueil, 31059 Toulouse cedex 9, France.
authors.forename: L
authors.initials: L
authors.lastname: Crognier
authors.affiliation: Pôle d'anesthésie réanimation, hôpital de Rangueil, 31059 Toulouse cedex 9, France.
authors.forename: T
authors.initials: T
authors.lastname: Seguin
authors.affiliation: Pôle d'anesthésie réanimation, hôpital de Rangueil, 31059 Toulouse cedex 9, France.
authors.forename: B
authors.initials: B
authors.lastname: Georges
authors.affiliation: Pôle d'anesthésie réanimation, hôpital de Rangueil, 31059 Toulouse cedex 9, France.
authors.forename: O
authors.initials: O
authors.lastname: Fourcade
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy*; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications; D000991:Antithrombins / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications; D001562:Benzimidazoles / Q000009:adverse effects* / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000139:chemically induced; D000069604:Dabigatran; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D062787:Drug Overdose / Q000628:therapy*; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D006947:Hyperkalemia / Q000209:etiology; D008297:Male; D009369:Neoplasms / Q000601:surgery; D010689:Phlebitis / Q000628:therapy; D006435:Renal Dialysis / Q000379:methods*; D015091:beta-Alanine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000991:Antithrombins; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran
keywords: Acute renal injury; Dabigatran; Hemodialysis; Hémodialyse; Hémorragie; Insuffisance rénale aiguë; Overdose; Surdosage