title: The role of obesity in gastrointestinal cancer: evidence and opinion.
abstract: There is increasing recognition of the impact of being overweight and obese on the development of cancers at diverse sites including the gastrointestinal tract. Large epidemiological studies indicate that up to 14% of tumours may be related to obesity. Pathophysiological mechanisms underpinning this association are not well understood and so are discussed in this review.
authors.affiliation: Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin/ St James' Hospital, Dublin, Ireland.
authors.forename: Claire L
authors.initials: CL
authors.lastname: Donohoe
authors.affiliation: Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin/ St James' Hospital, Dublin, Ireland.
authors.forename: Naoimh J
authors.initials: NJ
authors.lastname: O'Farrell
authors.affiliation: Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin/ St James' Hospital, Dublin, Ireland.
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Doyle
authors.affiliation: Department of Surgery, Trinity Centre for Health Sciences, Trinity College Dublin/ St James' Hospital, Dublin 8, Ireland.
authors.forename: John V
authors.initials: JV
authors.lastname: Reynolds
keywords: adipose tissue, carcinogenesis; inflammation; signalling pathways; visceral adiposity