title: Antcamphins A-L, ergostanoids from Antrodia camphorata.
abstract: Twelve ergostanoids, named antcamphins A-L (1-12), together with 20 known triterpenoids, were isolated from fruiting bodies of the medicinal fungus Antrodia camphorata. Compounds 1 and 2 represent the first examples of norergostanes isolated from A. camphorata, and compounds 3 and 4 are the first pair of cis-trans isomers of ergostane-type triterpenoids containing an aldehyde group. Compounds 5-12 are four pairs of C-25 epimers. The structures of 1-12 were elucidated on the basis of extensive spectroscopic data analysis including NMR and HRESIMS. Particularly, the absolute configurations at C-25 for 5-12 were determined by the modified Mosher's method. These triterpenoids exhibited weak cytotoxic activities against MDA-MB-231 breast cancer cells and A549 lung cancer cells, but did not inhibit the growth of normal cells in the sulforhodamine B assay.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University , Beijing 100191, People's Republic of China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.forename: Xionghao
authors.initials: X
authors.lastname: Lin
authors.forename: Xue
authors.initials: X
authors.lastname: Qiao
authors.forename: Shuai
authors.initials: S
authors.lastname: Ji
authors.forename: Kedi
authors.initials: K
authors.lastname: Liu
authors.forename: Chi-tai
authors.initials: CT
authors.lastname: Yeh
authors.forename: Yew-min
authors.initials: YM
authors.lastname: Tzeng
authors.forename: Dean
authors.initials: D
authors.lastname: Guo
authors.forename: Min
authors.initials: M
authors.lastname: Ye
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D055491:Antrodia / Q000737:chemistry*; D027424:Cinnamomum / Q000382:microbiology; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D012235:Rhodamines / Q000494:pharmacology; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D012235:Rhodamines; D014315:Triterpenes; C022027:lissamine rhodamine B; C015190:ergostane; D004875:Ergosterol