title: Astrocytes and the evolution of the human brain.
abstract: Cells within the astroglial lineage are proposed as the origin of human brain evolution. It is now widely accepted that they direct mammalian fetal neurogenesis, gliogenesis, laminar cytoarchitectonics, synaptic connectivity and neuronal network formation. Furthermore, genetic, anatomical and functional studies have recently identified multiple astrocyte exaptations that strongly suggest a direct relation to the increased size and complexity of the human brain.
authors.affiliation: 2849 Zeeland Avenue, Baton Rouge, LA 70808, United States. Electronic address: james.jimmd@gmail.com.
authors.forename: James M
authors.initials: JM
authors.lastname: Robertson
mesh_terms: D000818:Animals; D017209:Apoptosis; D001253:Astrocytes / Q000166:cytology*; D005075:Biological Evolution; D001921:Brain / Q000473:pathology* / Q000502:physiology*; D002454:Cell Differentiation; D019070:Cell Lineage; D003071:Cognition; D014644:Genetic Variation; D000882:Haplorhini; D006801:Humans; D051379:Mice; D008962:Models, Theoretical; D055495:Neurogenesis; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology; D019699:Thrombospondins / Q000378:metabolism
chemical_list: D019699:Thrombospondins