title: Gasotransmitter regulation of ion channels: a key step in O2 sensing by the carotid body.
abstract: Carotid bodies detect hypoxia in arterial blood, translating this stimulus into physiological responses via the CNS. It is long established that ion channels are critical to this process. More recent evidence indicates that gasotransmitters exert powerful influences on O2 sensing by the carotid body. Here, we review current understanding of hypoxia-dependent production of gasotransmitters, how they regulate ion channels in the carotid body, and how this impacts carotid body function.
authors.affiliation: Institute for Integrative Physiology and Center for Systems Biology of O2 Sensing, Biological Sciences Division, University of Chicago, Chicago, Illinois; and.
authors.forename: Nanduri R
authors.initials: NR
authors.lastname: Prabhakar
authors.forename: Chris
authors.initials: C
authors.lastname: Peers
mesh_terms: D000818:Animals; D002344:Carotid Body / Q000378:metabolism* / Q000503:physiopathology; D004734:Energy Metabolism / Q000502:physiology*; D064426:Gasotransmitters / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D007473:Ion Channels / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*
chemical_list: D064426:Gasotransmitters; D007473:Ion Channels; D010100:Oxygen