title: [Multicenter surveillance of Pseudomonas aeruginosa strains for antimicrobials in Aichi prefecture in 2009].
abstract: We investigated the susceptibility to antimicrobials of 204 Pseudomonas aeruginosa strains isolated from 21 hospitals in Aichi prefecture from September to November 2009. MIC distributions of various antimicrobials were analyzed in terms of geographic region of isolation, patient status (outpatient or inpatient), and type of specimens that the strain was isolated from. The results were as follows. 1. Although more than 90% of strains were susceptible to all aminoglycosides and colistin, 80-90% of them were susceptible to beta-lactams and fluoroquinolones. MIC distributions of all antimicrobials measured were not significantly different between regions. 2. Only 1 strain (0.5%) was multi-drug resistant Pseudomonas aeruginosa (MDRP). Thirteen strains (6.4%) showed imipenem MIC > or = 16 microg/mL, and 16 strains (7.8%) showed ciprofloxacin MIC > or = 4 microg/mL. These strains tended to be more isolated from urine, respiratory tract specimens, or surgical specimens. 3. The MICs of tazobactam/piperacillin, panipenem, meropenem, doripenem, biapenem, sulbactam/cefoperazone, cefepime, and aztreonam were significantly higher in strains isolated from inpatients than in those from outpatients. MIC distributions of antimicrobials other than beta-lactams were not significantly different between situations where strains were isolated. 4. MIC distributions of piperacillin, all carbapenems, cefepime, gentamicin, and all fluoroquinolones were significantly different among samples from which strains were isolated. The strains isolated from blood showed lower MICs against all antimicrobials than those from other samples. No difference was found in MIC distributions when categorized according to bacteremic origin. The MICs were apparently elevated against beta-lactams, fluoroquinolones, and gentamicin in strains isolated from respiratory tract specimens, and against beta-lactams, and fluoroquinolones in strains isolated from urine. It was suggested that in P. aeruginosa surveillance, the results should be reported by stratifying with patient status, and type of specimens that the strain was isolated from and that regional surveillance should be useful with such stratification to establish antibiograms for empirical antimicrobial choice.
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Iguchi
authors.forename: Mariko
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yagi
authors.forename: Hironaga
authors.initials: H
authors.lastname: Ookawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Shimazaki
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Ootsuka
authors.forename: Kazuya
authors.initials: K
authors.lastname: Sato
authors.forename: Arufumi
authors.initials: A
authors.lastname: Shiota
authors.forename: Naoki
authors.initials: N
authors.lastname: Wakiyama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakamura
authors.forename: Mariko
authors.initials: M
authors.lastname: Kidono
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hara
authors.forename: Sachie
authors.initials: S
authors.lastname: Asai
authors.forename: Makoto
authors.initials: M
authors.lastname: Kawashima
authors.forename: Kazuko
authors.initials: K
authors.lastname: Sakuragi
authors.forename: Jitsuko
authors.initials: J
authors.lastname: Asahi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Murase
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nishio
authors.forename: Yuki
authors.initials: Y
authors.lastname: Miyaki
authors.forename: Keiji
authors.initials: K
authors.lastname: Funahashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Mouri
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Sugiura
authors.forename: Takako
authors.initials: T
authors.lastname: Yamada
authors.forename: Konomi
authors.initials: K
authors.lastname: Kondo
authors.forename: Kaori
authors.initials: K
authors.lastname: Sahara
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Sugaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawabata
authors.forename: Yumi
authors.initials: Y
authors.lastname: Itou
authors.forename: Yu
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Ikuo
authors.initials: I
authors.lastname: Yamaguchi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Sasano
authors.forename: Tomomi
authors.initials: T
authors.lastname: Inukai
authors.forename: Natsuko
authors.initials: N
authors.lastname: Matsui
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kuramae
authors.forename: Masaru
authors.initials: M
authors.lastname: Okugawa
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawai
authors.forename: Motohiro
authors.initials: M
authors.lastname: Shibata
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Inuzuka
authors.forename: Atsuko
authors.initials: A
authors.lastname: Yamada
authors.forename: Isao
authors.initials: I
authors.lastname: Koita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suematsu
authors.forename: Haruki
authors.initials: H
authors.lastname: Sawamura
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Mikamo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents