title: Synthesis and synergistic, additive inhibitory effects of novel spiro derivatives against ringworm infections.
abstract: An environmentally benign solvent free synthesis of various spiro-1,4-dihydropyridines (1,4-DHPs) incorporating 2-oxindole/piperidines is performed in 5-8 min with reasonable purity in 80-90% yield under microwave irradiation using montmorillonite KSF as an inorganic solid support. The reaction is found to be general with respect to various cyclic carbonyl compounds, e.g. cyclohexanone, substituted indole-2,3-dione, and piperidinone derivatives. In our study, these compounds were also found effective against dermatophytes and other fungal organisms. Our results suggest that novel spiro derivatives can be used for the treatment of dermatophytosis or ringworm infections.
authors.affiliation: Department of Chemical Sciences, Suresh Gyan Vihar University, Jaipur. gnsharma2020@gmail.com
authors.forename: Gajanand
authors.initials: G
authors.lastname: Sharma
authors.affiliation: Department of Biotechnology and Food Science, Jayoti Vidyapeeth Women's University, Jaipur.
authors.forename: Richa
authors.initials: R
authors.lastname: Sharma
authors.affiliation: Anshu Dandia, Centre of Advanced Studies, Department of Chemistry, University of Rajasthan.
authors.forename: Anshu
authors.initials: A
authors.lastname: Dandia
authors.affiliation: Department of Chemical Sciences, Suresh Gyan Vihar University, Jaipur.
authors.forename: Preeti
authors.initials: P
authors.lastname: Bansal
mesh_terms: D001546:Bentonite / Q000737:chemistry; D003022:Clotrimazole / Q000008:administration & dosage; D003512:Cyclohexanones / Q000737:chemistry; D004095:Dihydropyridines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007211:Indoles / Q000737:chemistry; D007654:Ketoconazole / Q000008:administration & dosage; D008872:Microwaves; D000078183:Oxindoles; D013141:Spiro Compounds / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000737:chemistry; D014005:Tinea / Q000188:drug therapy* / Q000473:pathology; D014249:Trichophyton / Q000187:drug effects*
chemical_list: D003512:Cyclohexanones; D004095:Dihydropyridines; D007211:Indoles; D000078183:Oxindoles; D013141:Spiro Compounds; C523398:montmorillonite KSF; C022960:2-oxindole; D001546:Bentonite; C036468:cyclohexanone; D003022:Clotrimazole; D007654:Ketoconazole