title: Parametric likelihood inference for interval censored competing risks data.
abstract: Parametric estimation of the cumulative incidence function (CIF) is considered for competing risks data subject to interval censoring. Existing parametric models of the CIF for right censored competing risks data are adapted to the general case of interval censoring. Maximum likelihood estimators for the CIF are considered under the assumed models, extending earlier work on nonparametric estimation. A simple naive likelihood estimator is also considered that utilizes only part of the observed data. The naive estimator enables separate estimation of models for each cause, unlike full maximum likelihood in which all models are fit simultaneously. The naive likelihood is shown to be valid under mixed case interval censoring, but not under an independent inspection process model, in contrast with full maximum likelihood which is valid under both interval censoring models. In simulations, the naive estimator is shown to perform well and yield comparable efficiency to the full likelihood estimator in some settings. The methods are applied to data from a large, recent randomized clinical trial for the prevention of mother-to-child transmission of HIV.
authors.affiliation: Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7420, U.S.A.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Hudgens
authors.forename: Chenxi
authors.initials: C
authors.lastname: Li
authors.forename: Jason P
authors.initials: JP
authors.lastname: Fine
mesh_terms: D001942:Breast Feeding / Q000009:adverse effects; D003198:Computer Simulation; D005260:Female; D006678:HIV / Q000276:immunology; D015658:HIV Infections / Q000276:immunology / Q000635:transmission; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D016013:Likelihood Functions; D008295:Malawi; D015233:Models, Statistical
keywords: Competing risks; Cumulative incidence function; Gompertz; HIV/AIDS; Maximum likelihood