title: Hearing status in adult individuals with lifetime, untreated isolated growth hormone deficiency.
abstract: OBJECTIVE
  To evaluate the hearing status of growth hormone (GH)-naive adults with isolated GH deficiency (IGHD) belonging to an extended Brazilian kindred with a homozygous mutation in the GH-releasing hormone receptor gene.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Divisions of Endocrinology and Otorhinolaryngology of the Federal University of Sergipe.
  
  
  METHODS
  Twenty-six individuals with IGHD (age, 47.6 ± 15.1 years; 13 women) and 25 controls (age, 46.3 ± 14.3 years; 15 women) were administered a questionnaire on hearing complaints and hearing health history. We performed pure-tone audiometry, logoaudiometry, electroacoustic immittance, and stapedial reflex. To assess outer hair cell function in the cochlea, we completed transient evoked otoacoustic emissions (TEOAEs). To assess the auditory nerve and auditory brainstem, we obtained auditory brainstem responses (ABRs).
  
  
  RESULTS
  Misophonia and dizziness complaints were more frequent in those with IGHD than in controls (P = .011). Patients with IGHD had higher thresholds at 250 Hz (P = .005), 500 Hz (P = .006), 3 KHz (P = .008), 4 KHz (P = .038), 6 KHz (P = .008), and 8 KHz (P = .048) and mild high-tones hearing loss (P = .029). Stapedial reflex (P < .001) and TEOAEs (P = .025) were more frequent in controls. There were no differences in ABR latencies. Hearing loss in patients with IGHD occurred earlier than in controls (P < .001).
  
  
  CONCLUSIONS
  Compared with controls of the same area, subjects with untreated, congenital lifetime IGHD report more misophonia and dizziness, have predominance of mild high-tones sensorineural hearing loss, and have an absence of stapedial reflex and TEOAEs.
authors.affiliation: Division of Otorhinolaryngology, Federal University of Sergipe, Aracaju, Sergipe, Brazil.
authors.forename: Valéria M
authors.initials: VM
authors.lastname: Prado-Barreto
authors.forename: Roberto
authors.initials: R
authors.lastname: Salvatori
authors.forename: Ronaldo C
authors.initials: RC
authors.lastname: Santos Júnior
authors.forename: Mariane B
authors.initials: MB
authors.lastname: Brandão-Martins
authors.forename: Eric A
authors.initials: EA
authors.lastname: Correa
authors.forename: Flávia B
authors.initials: FB
authors.lastname: Garcez
authors.forename: Eugênia H O
authors.initials: EH
authors.lastname: Valença
authors.forename: Anita H O
authors.initials: AH
authors.lastname: Souza
authors.forename: Rossana M C
authors.initials: RM
authors.lastname: Pereira
authors.forename: Marco A P
authors.initials: MA
authors.lastname: Nunes
authors.forename: Jeferson S
authors.initials: JS
authors.lastname: D'Avila
authors.forename: Manuel H
authors.initials: MH
authors.lastname: Aguiar-Oliveira
mesh_terms: D000328:Adult; D001301:Audiometry, Pure-Tone; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004393:Dwarfism, Pituitary / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006309:Hearing / Q000502:physiology*; D034381:Hearing Loss / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous; D011795:Surveys and Questionnaires
keywords: hearing; hearing loss; isolated growth hormone deficiency