title: Autophagy and hippocampal neuronal injury.
abstract: BACKGROUND
  Autophagy is a specific universal biological phenomenon in eukaryotic cells, which is characterized by cytoplasmic vacuoles in the process of degrading cellular contents in lysosomes. The hippocampus plays an important role in higher nervous activities such as emotional integration, cognition, and memory. As an area closely related to learning and memory functions of the brain, the hippocampus is particularly sensitive to injuries caused by various reasons.
  
  
  OBJECTIVE
  Autophagy has certain links with a variety of causes of hippocampal neuronal injury. This short review discusses and summarizes this correlation with a focus on the possible role of autophagy and mechanisms in it.
  
  
  CONCLUSIONS
  The current correlation between autophagy and hippocampal neuronal injury has not been completely determined by the general public alike. Further studies are needed to determine special effects of autophagy on hippocampal neuronal injury, which might accelerate the development of therapeutic interventions in hippocampal neuronal injury in many neurological disorders.
authors.affiliation: Tianjin Institute of Geriatrics, Tianjin Medical University General Hospital, Anshan Road, Tianjin, 300052, China.
authors.forename: Lulu
authors.initials: L
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Tan
authors.forename: Yunyun
authors.initials: Y
authors.lastname: Fang
authors.forename: Xu
authors.initials: X
authors.lastname: An
authors.forename: Baoyuan
authors.initials: B
authors.lastname: Chen
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D001343:Autophagy / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D006624:Hippocampus / Q000503:physiopathology*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000503:physiopathology*; D009474:Neurons / Q000502:physiology*; D009498:Neurotoxins / Q000494:pharmacology / Q000506:poisoning* / Q000633:toxicity*
chemical_list: D009498:Neurotoxins