title: Novel prenylated bichalcone and chalcone from Humulus lupulus and their quinone reductase induction activities.
abstract: A new prenylated chalcone xanthohumol M (1), a novel prenylated bichalcone humulusol (2) and six known chalcones (3-8) were found from Humulus lupulus. Their structures were determined by spectroscopic methods. All the chalcones' electrophilic abilities were assessed by GSH (glutathione) rapid screening, and their QR (quinone reductase) induction activities were evaluated using hepa 1c1c7 cells. The results of electrophilic assay and QR induction activity assay were quite well. New compounds 1 and 2, along with some known prenylated chalcones, displayed certain QR induction activity.
authors.affiliation: Institute of Marine Biology & Natural Products, Ocean College, Zhejiang University, No. 866 Yuhangtang Rd., Hangzhou 310058, China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Yu
authors.affiliation: Quzhou Academy of Agricultural Sciences (Zhejiang Province), Quzhou 324000, China.
authors.forename: Fuxian
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Institute of Marine Biology & Natural Products, Ocean College, Zhejiang University, No. 866 Yuhangtang Rd., Hangzhou 310058, China.
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Hu
authors.affiliation: Institute of Marine Biology & Natural Products, Ocean College, Zhejiang University, No. 866 Yuhangtang Rd., Hangzhou 310058, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.affiliation: Zhejiang Respiratory Drugs Research Laboratory of State Foods & Drugs Administration of China, School of Medicine, Zhejiang University, Hangzhou 310058, China.
authors.forename: Huifang
authors.initials: H
authors.lastname: Tang
authors.affiliation: Institute of Marine Biology & Natural Products, Ocean College, Zhejiang University, No. 866 Yuhangtang Rd., Hangzhou 310058, China. Electronic address: mazj@zju.edu.cn.
authors.forename: Zhongjun
authors.initials: Z
authors.lastname: Ma
authors.affiliation: Zhejiang Provincial People's Hospital, No. 158 Shangtang Rd., Hangzhou 310014, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification*; D050150:Chalones / Q000737:chemistry / Q000302:isolation & purification*; D004790:Enzyme Induction; D027582:Humulus / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000096:biosynthesis*; D054876:Prenylation
chemical_list: D047188:Chalcones; D050150:Chalones; C000595229:humulusol; C000595228:xanthohumol M; D016660:NAD(P)H Dehydrogenase (Quinone)
keywords: Electrophilic; Humulusol; Prenylated chalcone; QR induction; Xanthohumol M