title: [Progress on mechanism of cell apoptosis induced by rubella virus].
abstract: Rubella virus (RV), a member of the family Togaviridae, can induce apoptosis of host cells in vitro. Protein kinases of the Ras-Raf-MEK-ERK pathway and PI3K-Akt pathway play essential roles in virus multiplication, cell survival and apoptosis. Proteins p53 and TAp63 that bind to specific DNA sequences stimulate Bax in a manner to produce functional pores that facilitate release of mitochondrial cytochrome c and downstream caspase activation. In this review, the molecular mechanisms of RV-induced cell apoptosis, including RV-infected cell lines, pathological changes in cell components and apoptosis signaling pathways are summarized.
authors.affiliation: Department of Virology, School of Public Health, Key Laboratory for Experimental Teratology of the Ministry of Education, Shandong University, Jinan 250012, China. meizi_chongzi@163.com
authors.forename: Zhen-mei
authors.initials: ZM
authors.lastname: Li
authors.affiliation: Department of Virology, School of Public Health, Key Laboratory for Experimental Teratology of the Ministry of Education, Shandong University, Jinan 250012, China.
authors.forename: Fu-lu
authors.initials: FL
authors.lastname: Chu
authors.affiliation: Department of Virology, School of Public Health, Key Laboratory for Experimental Teratology of the Ministry of Education, Shandong University, Jinan 250012, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Virology, School of Public Health, Key Laboratory for Experimental Teratology of the Ministry of Education, Shandong University, Jinan 250012, China.
authors.forename: Zhi-yu
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D017209:Apoptosis; D006801:Humans; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism; D012409:Rubella / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology* / Q000821:virology; D012412:Rubella virus / Q000235:genetics / Q000502:physiology*
chemical_list: D020928:Mitogen-Activated Protein Kinases