title: Gold nanoshelled liquid perfluorocarbon magnetic nanocapsules: a nanotheranostic platform for bimodal ultrasound/magnetic resonance imaging guided photothermal tumor ablation.
abstract: Imaging guided ablation therapy has been applied in both biomedical research and clinical trials and turned out to be one of the most promising approaches for cancer treatment. Herein, the multifunctional nanocapsules were fabricated through loading perfluorooctylbromide (PFOB) and superparamagnetic iron oxide nanoparticles (SPIOs) into poly(lactic acid) (PLA) nanocapsules (NCs), followed by the formation of PEGylated gold nanoshell on the surface. The resulting multi-component NCs were proved to be able to act as nanotheranostic agent to achieve successful bimodal ultrasound (US)/magnetic resonance imaging (MRI) guided photothermal ablation in human tumor xenograft models non-invasively. Such a single theranostic agent with the combination of real-time US and high-resolution MR imaging would be of great value to offer more comprehensive diagnostic information and dynamics of disease progression for the accurate location of therapeutic focusing spot in the targeted tumor tissue, showing great potential as an effective nanoplatform for contrast imaging guided photothermal therapy.
authors.affiliation: 2. Nanomedicine and Biosensor Laboratory, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.
authors.forename: Hengte
authors.initials: H
authors.lastname: Ke
authors.affiliation: 1. College of Engineering and Peking University Third Hospital, Peking University, Beijing 100871, China;
authors.forename: Jinrui
authors.initials: J
authors.lastname: Wang
authors.affiliation: 3. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.
authors.forename: Sheng
authors.initials: S
authors.lastname: Tong
authors.affiliation: 2. Nanomedicine and Biosensor Laboratory, School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China.
authors.forename: Yushen
authors.initials: Y
authors.lastname: Jin
authors.affiliation: 1. College of Engineering and Peking University Third Hospital, Peking University, Beijing 100871, China;
authors.forename: Shumin
authors.initials: S
authors.lastname: Wang
authors.affiliation: 1. College of Engineering and Peking University Third Hospital, Peking University, Beijing 100871, China;
authors.forename: Enze
authors.initials: E
authors.lastname: Qu
authors.affiliation: 3. Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia 30332, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Bao
authors.affiliation: 1. College of Engineering and Peking University Third Hospital, Peking University, Beijing 100871, China;
authors.forename: Zhifei
authors.initials: Z
authors.lastname: Dai
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005466:Fluorocarbons / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D064847:Multimodal Imaging / Q000379:methods; D053769:Nanocapsules / Q000737:chemistry; D009374:Neoplasms, Experimental / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy*; D061088:Photoacoustic Techniques / Q000379:methods*; D010778:Photochemotherapy / Q000379:methods*; D011817:Rabbits; D014463:Ultrasonography
chemical_list: D005466:Fluorocarbons; D058185:Magnetite Nanoparticles; D053769:Nanocapsules; D006046:Gold
keywords: Bimodal imaging; Gold nanoshell; Liquid perfluorocarbon nanocapules; Photothermal therapy.; Superparamagnetic iron oxide nanoparticles