title: Attenuated total reflection fourier transform infrared (ATR-FTIR) spectral discrimination of brain tumour severity from serum samples.
abstract: Gliomas are the most frequent primary brain tumours in adults with over 9,000 people diagnosed each year in the UK. A rapid, reagent-free and cost-effective diagnostic regime using serum spectroscopy would allow for rapid diagnostic results and for swift treatment planning and monitoring within the clinical environment. We report the use of ATR-FTIR spectral data combined with a RBF-SVM for the diagnosis of gliomas (high-grade and low-grade) from non-cancer with sensitivities and specificities on average of 93.75 and 96.53% respectively. The proposed diagnostic regime has the ability to reduce mortality and morbidity rates.
authors.affiliation: Centre for Materials Science, Division of Chemistry, JB Firth Building, University of Central Lancashire, Preston, PR1 2HE, UK.
authors.forename: James R
authors.initials: JR
authors.lastname: Hands
authors.forename: Konrad M
authors.initials: KM
authors.lastname: Dorling
authors.forename: Peter
authors.initials: P
authors.lastname: Abel
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Ashton
authors.forename: Andrew
authors.initials: A
authors.lastname: Brodbelt
authors.forename: Charles
authors.initials: C
authors.lastname: Davis
authors.forename: Timothy
authors.initials: T
authors.lastname: Dawson
authors.forename: Michael D
authors.initials: MD
authors.lastname: Jenkinson
authors.forename: Robert W
authors.initials: RW
authors.lastname: Lea
authors.forename: Carol
authors.initials: C
authors.lastname: Walker
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Baker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001932:Brain Neoplasms / Q000097:blood* / Q000175:diagnosis*; D055088:Early Detection of Cancer; D005260:Female; D005910:Glioma / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D055815:Young Adult
keywords: ATR-FTIR; cancer; filtrate; glioma; infrared; rapid; serum; spectroscopy