title: Medication adherence, knowledge about psychosis, and insight among patients with a schizophrenia-spectrum disorder.
abstract: This study aimed to explore the relationship between knowledge about psychosis, insight, and medication adherence among patients at an early stage of a schizophrenia-spectrum disorder. Eighty patients were recruited from a specialized outpatient clinic. Knowledge was assessed with the modified Knowledge About Schizophrenia Test (KAST). Medication adherence was determined with the Chinese abridged Medication Adherence Ratings Scale. Insight was measured with the abridged Scale to Assess Unawareness of Mental Disorder (SUMD). The KAST total score was correlated with the SUMD. A trend correlation between KAST subscores of cause and SUMD was found. The nonadherence rate was 43.8%. The medication-adherent patients had lower SUMD (z = -4.338, p < 0.0001) and higher KAST subscore of cause (z = -2.767, p = 0.006). These two variables explained 38.9% of the variance in adherence behavior, with SUMD being the mediator. This study highlights the importance of patients' understanding of etiology of the illness and its relationship with insight and medication adherence.
authors.affiliation: Department of Psychiatry, The University of Hong Kong, Hong Kong.
authors.forename: Kit Wa Sherry
authors.initials: KW
authors.lastname: Chan
authors.forename: Lai Ming Christy
authors.initials: LM
authors.lastname: Hui
authors.forename: Hoi Yan Gloria
authors.initials: HY
authors.lastname: Wong
authors.forename: Ho Ming Edwin
authors.initials: HM
authors.lastname: Lee
authors.forename: Wing Chung
authors.initials: WC
authors.lastname: Chang
authors.forename: Yu Hai Eric
authors.initials: YH
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D001364:Awareness; D032882:Comprehension; D003430:Cross-Sectional Studies; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000523:psychology; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology