title: Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk.
abstract: This study examined associations between MTHFR C677T polymorphism and serum folate concentrations with the risk of esophageal precancerous lesions (EPL) and esophageal squamous cell carcinoma (ESCC). The highest quartile of serum folate concentration significantly decreased the risk of ESCC compared with the lowest quartile (OR=0.11; 95% Cl, 0.04-0.33; P<0.05). MTHFR 677 C>T polymorphism was associated with the risk of ESCC by using chi-square tests (P<0.05). For the CT genotype, the risk of ESCC significantly increased in study participants with low serm folate concentrations (≤26.92 μg/L) compared with participants with high serum folate concentrations (>26.92 μg/L) by using multinomial logistic regression models. The MTHFR genotype may further modify associations between serum folate concentrations and the risk of ESCC, but it was not significantly associated with the risk of EPL.
authors.affiliation: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, Jiangsu, China.
authors.forename: Gui Ling
authors.initials: GL
authors.lastname: Huang
authors.forename: Shao Kang
authors.initials: SK
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Su
authors.forename: Ting Ting
authors.initials: TT
authors.lastname: Wang
authors.forename: Hui Zhen
authors.initials: HZ
authors.lastname: Cai
authors.forename: Hong
authors.initials: H
authors.lastname: Yin
authors.forename: Gui Ju
authors.initials: GJ
authors.lastname: Sun
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000235:genetics*; D016009:Chi-Square Distribution; D004938:Esophageal Neoplasms / Q000097:blood / Q000235:genetics*; D005492:Folic Acid / Q000097:blood*; D020022:Genetic Predisposition to Disease; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2)