title: [Efficacy of oxaliplatin-based chemotherapy in Stage IV colorectal cancer patients with peritoneal carcinomatosis].
abstract: OBJECTIVE
  This retrospective study evaluated the outcome of oxaliplatin-based chemotherapy for peritoneal metastasis from colorectal cancer.
  
  
  METHODS
  The study included 49 patients with peritoneal metastasis from colorectal cancer who underwent oxaliplatin-based chemotherapy between January 2006 and November 2012 and 25 patients who underwent systematic chemotherapy before oxaliplatin-based chemotherapy. Patient background characteristics, overall survival(l OS), and prognostic outcomes were examined.
  
  
  RESULTS
  OS was significantly longer in patients treated with oxaliplatin -based chemotherapy than in those treated with prior chemotherapy( median, 20.5 months vs 11.7 months, p= 0.04). Multivariate analysis showed that treatment with oxaliplatin-based chemotherapy, age less than 70 years(p=0.03), and primary tumor resection( p=0.02) were significant independent factors affecting OS.
  
  
  CONCLUSIONS
  Oxaliplatin-based chemotherapy improved the prognosis of patients with peritoneal metastasis from colorectal cancer. In the treatment of such patients, initiation of chemotherapy after primary tumor resection appears to be important, especially in patients aged <70 years.
authors.affiliation: Dept. of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hatano
authors.forename: Takeaki
authors.initials: T
authors.lastname: Matsuzawa
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kumamoto
authors.forename: Minoru
authors.initials: M
authors.lastname: Fukuchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Baba
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kumagai
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Norihiro
authors.initials: N
authors.lastname: Haga
authors.forename: Erito
authors.initials: E
authors.lastname: Mochiki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage*; D000077150:Oxaliplatin; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin