title: Diagnostic role of core needle biopsy in cervical lymphadenopathy.
abstract: BACKGROUND
  The purpose of this study was to evaluate the value of core needle biopsy (CNB) compared to fine-needle aspiration cytology (FNAC) in cervical lymphadenopathy.
  
  
  METHODS
  This consecutive case series enrolled 208 patients with cervical lymphadenopathy. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were evaluated and the necessity of an additional open biopsy was compared.
  
  
  RESULTS
  The sensitivity and NPV for critical disease (lymphoma, carcinoma, and tuberculosis) were significantly higher with CNB (p = .006, p = .001, respectively) than with FNAC. In the analysis based on specific disease, the sensitivity of CNB was statistically significantly higher (p = .009) for the diagnosis of lymphoma. The rate of open biopsy for confirmative diagnosis was significantly lower with CNB (p = .014).
  
  
  CONCLUSIONS
  CNB is beneficial for initial examination in cervical lymphadenopathy and showed higher sensitivity and NPV than FNAC. It is especially useful for screening for lymphoma.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea.
authors.forename: Yoon-Jong
authors.initials: YJ
authors.lastname: Ryu
authors.forename: Wonjae
authors.initials: W
authors.lastname: Cha
authors.forename: Woo-Jin
authors.initials: WJ
authors.lastname: Jeong
authors.forename: Sang Il
authors.initials: SI
authors.lastname: Choi
authors.forename: Soon-Hyun
authors.initials: SH
authors.lastname: Ahn
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008223:Lymphoma / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis; D055815:Young Adult
keywords: core needle biopsy; fine-needle aspiration cytology; lymphadenopathy; lymphoma; metastasis