title: Initial transfusion intensity predicts survival in myelodysplastic syndrome.
abstract: We evaluated 52 patients with myelodysplastic syndrome (MDS) who had received at least one red blood cell (RBC) transfusion. In the 4-week period following the first transfusion, 24 patients (group 1) required no transfusion, while 28 (group 2) required transfusion of two or more units of RBCs. Survival was greater in group 1 (440 weeks vs. 167 weeks, p < 0.01), even when only international prognostic scoring system (IPSS) low and intermediate-1 risk patients were analyzed (median overall survival 491 vs. 170 weeks, p < 0.05), independent of age, IPSS and progression to acute myeloid leukemia (AML). The intensity of transfusion required in the first few weeks after the first transfusion predicts disease severity and correlates with survival.
authors.affiliation: Molecular and Cellular Biology, Sunnybrook Research Institute , Toronto, ON , Canada.
authors.forename: Lap Shu Alan
authors.initials: LS
authors.lastname: Chan
authors.forename: Roman
authors.initials: R
authors.lastname: Shapiro
authors.forename: Rena
authors.initials: R
authors.lastname: Buckstein
authors.forename: Yulia
authors.initials: Y
authors.lastname: Lin
authors.forename: Jeannie
authors.initials: J
authors.lastname: Callum
authors.forename: Lisa
authors.initials: L
authors.lastname: Chodirker
authors.forename: Christina D
authors.initials: CD
authors.lastname: Lee
authors.forename: Anca
authors.initials: A
authors.lastname: Prica
authors.forename: Adam
authors.initials: A
authors.lastname: Lam
authors.forename: Alexandre
authors.initials: A
authors.lastname: Mamedov
authors.forename: Richard A
authors.initials: RA
authors.lastname: Wells
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001803:Blood Transfusion; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000401:mortality* / Q000628:therapy*; D016017:Odds Ratio; D011379:Prognosis; D012307:Risk Factors
keywords: Myelodysplastic syndrome; prognosis; transfusion