title: Converting oxazoles into imidazoles: new opportunities for diversity-oriented synthesis.
abstract: We report the optimization of a neglected reaction for the rapid and direct conversion of oxazoles into N-substituted imidazoles. The utility of this microwave-promoted reaction for diversity-oriented synthesis is demonstrated in the preparation of >40 N-substituted imidazoles, including α-imidazolyl esters.
authors.affiliation: Medicinal Chemistry, Small Molecule Research, Pharma Research & Early Development (pRED), F. Hoffmann-La Roche AG, Grenzacherstrasse 124, 4070 Basel, Switzerland. rainer_e.martin@roche.com.
authors.forename: Thibaut
authors.initials: T
authors.lastname: Alzieu
authors.forename: Johannes
authors.initials: J
authors.lastname: Lehmann
authors.forename: Ajay B
authors.initials: AB
authors.lastname: Naidu
authors.forename: Rainer E
authors.initials: RE
authors.lastname: Martin
authors.forename: Robert
authors.initials: R
authors.lastname: Britton
mesh_terms: D060326:Chemistry Techniques, Synthetic; D004952:Esters; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D010080:Oxazoles / Q000737:chemistry*
chemical_list: D004952:Esters; D007093:Imidazoles; D010080:Oxazoles