title: Guardian of the furnace: mitochondria, TRAP1, ROS and stem cell maintenance.
abstract: Mitochondria are key to eukaryotic cell survival and their activity is linked to generation of reactive oxygen species (ROS) which in turn acts as both an intracellular signal and an effective executioner of cells with regards to cellular senescence. The mitochondrial molecular chaperone tumor necrosis factor receptor associated protein 1 (TRAP1) is often termed the cytoprotective chaperone for its role in cancer cell survival and protection from apoptosis. Here, we hypothesize that TRAP1 serves to modulate mitochondrial activity in stem cell maintenance, survival and differentiation.
authors.affiliation: Biomedical Biotechnology Research Unit, Department of Biochemistry, Microbiology and Biotechnology, Rhodes University, Grahamstown, South Africa.
authors.forename: Rose
authors.initials: R
authors.lastname: Kadye
authors.forename: Adam H
authors.initials: AH
authors.lastname: Kramer
authors.forename: Julia
authors.initials: J
authors.lastname: Joos-Vandewalle
authors.forename: Michelle
authors.initials: M
authors.lastname: Parsons
authors.forename: Zikhona
authors.initials: Z
authors.lastname: Njengele
authors.forename: Heinrich
authors.initials: H
authors.lastname: Hoppe
authors.forename: Earl
authors.initials: E
authors.lastname: Prinsloo
mesh_terms: D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D018832:Molecular Chaperones / Q000378:metabolism*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013234:Stem Cells / Q000378:metabolism*
chemical_list: D018841:HSP90 Heat-Shock Proteins; D018832:Molecular Chaperones; D017382:Reactive Oxygen Species; C092306:TRAP1 protein, human
keywords: TRAP1; cancer; mitochondria; reactive oxygen species; stem cells