title: Streptozotocin-induced diabetic ketoacidosis in a patient with metastatic islet-cell carcinoma.
abstract: Here we report a severe life-threatening complication of treatment with streptozotocin in a patient with pancreatic island-cell carcinoma. The patient was admitted to the intensive care unit with severe diabetic ketoacidosis which needed aggressive fluid resuscitation and insulin therapy. We believe it is critical to be aware of the symptoms of diabetic ketoacidosis and monitor glucose levels during streptozotocin treatment.
authors.affiliation: Department of Internal Medicine, Maasziekenhuis Pantein, Boxmeer, the Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Berends
authors.forename: W J
authors.initials: WJ
authors.lastname: Lesterhuis
authors.forename: H W M
authors.initials: HW
authors.lastname: van Laarhoven
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000009:adverse effects* / Q000627:therapeutic use; D018273:Carcinoma, Islet Cell / Q000188:drug therapy; D016883:Diabetic Ketoacidosis / Q000139:chemically induced* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D013311:Streptozocin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000903:Antibiotics, Antineoplastic; D013311:Streptozocin