title: Oxidative stress-induced autophagy: role in pulmonary toxicity.
abstract: Autophagy is an evolutionarily conserved catabolic process important in regulating the turnover of essential proteins and in elimination of damaged organelles and protein aggregates. Autophagy is observed in the lung in response to oxidative stress generated as a consequence of exposure to environmental toxicants. Whether autophagy plays role in promoting cell survival or cytotoxicity is unclear. In this article recent findings on oxidative stress-induced autophagy in the lung are reviewed; potential mechanisms initiating autophagy are also discussed. A better understanding of autophagy and its role in pulmonary toxicity may lead to the development of new strategies to treat lung injury associated with oxidative stress.
authors.affiliation: Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
authors.forename: Rama
authors.initials: R
authors.lastname: Malaviya
authors.affiliation: Department of Environmental and Occupational Medicine, Robert Wood Johnson Medical School, Rutgers University, Piscataway, NJ 08854, USA.
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Laskin
authors.affiliation: Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA. Electronic address: laskin@eohsi.rutgers.edu.
authors.forename: Debra L
authors.initials: DL
authors.lastname: Laskin
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D055370:Lung Injury / Q000139:chemically induced / Q000473:pathology*; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D000393:Air Pollutants; D017382:Reactive Oxygen Species
keywords: Autophagy; Cytotoxicity; Lung injury; Oxidative stress; Pulmonary toxicants; p62