title: Development of vertical SU-8 microtubes integrated with dissolvable tips for transdermal drug delivery.
abstract: Polymer-based microneedles have drawn much attention in the transdermal drug delivery resulting from their flexibility and biocompatibility. Traditional fabrication approach deploys various kinds of molds to create sharp tips at the end of needles for the penetration purpose. This approach is usually time-consuming and expensive. In this study, we developed an innovative fabrication process to make biocompatible SU-8 microtubes integrated with biodissolvable maltose tips as novel microneedles for the transdermal drug delivery applications. These microneedles can easily penetrate the skin's outer barrier represented by the stratum corneum (SC) layer. The drug delivery device of mironeedles array with 1000 μm spacing between adjacent microneedles is proven to be able to penetrate porcine cadaver skins successfully. The maximum loading force on the individual microneedle can be as large as 7.36 ± 0.48N. After 9 min of the penetration, all the maltose tips are dissolved in the tissue. Drugs can be further delivered via these open biocompatible SU-8 microtubes in a continuous flow manner. The permeation patterns caused by the solution containing Rhodamine 110 at different depths from skin surface were characterized via a confocal microscope. It shows successful implementation of the microneedle function for fabricated devices.
authors.affiliation: Department of Electrical and Computer Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore ; Department of Pharmacy, National University of Singapore, 3 Science Drive 24, Singapore 117543, Singapore.
authors.forename: Zhuolin
authors.initials: Z
authors.lastname: Xiang
authors.affiliation: Department of Electrical and Computer Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pharmacy, National University of Singapore, 3 Science Drive 24, Singapore 117543, Singapore.
authors.forename: Aakanksha
authors.initials: A
authors.lastname: Pant
authors.affiliation: Department of Pharmacy, National University of Singapore, 3 Science Drive 24, Singapore 117543, Singapore.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Pastorin
authors.affiliation: Department of Electrical and Computer Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore.
authors.forename: Chengkuo
authors.initials: C
authors.lastname: Lee