title: Drug-induced lupus erythematosus presenting with cardiac tamponade: a case report and literature review.
abstract: The presentation of drug-induced lupus erythematosus (DILE) is typically mild, with a significantly lower incidence of life-threatening end-organ dysfunction relative to idiopathic systemic lupus erythematosus. DILE is an uncommon cause of cardiac tamponade but has been reported in patients treated with procainamide, isoniazid, hydralazine, sulfasalazine, and carbamazepine. We present a case of DILE presenting with cardiac tamponade associated with infliximab use that resolved with discontinuation of the medication and administration of high-dose steroids. In conclusion, DILE should be considered in the differential diagnosis in cases of pericarditis with cardiac tamponade without a clear cause.
authors.affiliation: Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada. Electronic address: dharnett@toh.on.ca.
authors.forename: David T
authors.initials: DT
authors.lastname: Harnett
authors.affiliation: St Clare's Mercy Hospital, Memorial University of Newfoundland, St John's, Newfoundland, Canada.
authors.forename: Harnahalli B
authors.initials: HB
authors.lastname: Chandra-Sekhar
authors.affiliation: St Clare's Mercy Hospital, Memorial University of Newfoundland, St John's, Newfoundland, Canada.
authors.forename: Sean F
authors.initials: SF
authors.lastname: Hamilton
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D002305:Cardiac Tamponade / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D003093:Colitis, Ulcerative / Q000188:drug therapy; D004452:Echocardiography; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D000069285:Infliximab; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000150:complications; D008297:Male; D020519:Pericardiocentesis; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab