title: [Pathological complete response in advanced gastric carcinoma with lymph node metastasis treated with combination neoadjuvant chemotherapy comprising S-1 and cisplatin-a case report].
abstract: A 55-year-old man with melena was referred to our hospital with suspicion of pancreatic cancer. Upper gastrointestinal endoscopy revealed a type 3 tumor in the greater curvature of the pylorus invading the duodenum. Examination of biopsy specimens showed poorly differentiated adenocarcinoma. Abdominal computed tomography (CT) and positron emission tomography (PET)-CT revealed a gastric tumor in the antrum and regional lymph node metastases invading the pancreas, indicating clinical stage IIIB (cT3, N2, H0, P0, M0) disease. Following 2 courses of neoadjuvant chemotherapy with S-1 plus cisplatin( CDDP), distal gastrectomy with D2 lymphadenectomy was performed. Histological examination revealed no residual cancer cells in the surgically obtained stomach and lymph node specimens, suggesting a complete pathological response( Grade 3). The patient was treated with S-1 for 1 year after surgery. Currently, at 54 months after surgery, the patient is in good health without recurrence.
authors.affiliation: Dept. of Surgery, Kansai Rosai Hospital.
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takeno
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Sato
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Morimoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kusama
authors.forename: Katsunori
authors.initials: K
authors.lastname: Matsushita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Kei
authors.initials: K
authors.lastname: Kimura
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Mukai
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Katsura
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kagawa
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Okishiro
authors.forename: Hideki
authors.initials: H
authors.lastname: Sakisaka
authors.forename: Shin
authors.initials: S
authors.lastname: Nakahira
authors.forename: Chiyomi
authors.initials: C
authors.lastname: Egawa
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeda
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kato
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tamura
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D005743:Gastrectomy; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin