title: [Prognostic risk factors associated with recurrence after curative resection in patients with stage II colorectal cancer].
abstract: The aim of this study was to clarify the risk factors associated with recurrence in patients with stage II colorectal cancer.
  
  
  METHODS
  We performed a retrospective analysis of 316 patients with stage II colorectal cancer who underwent gross radical colectomy between 1994 and 2003.
  
  
  RESULTS
  The overall recurrence rate was 10.8%. Univariate analysis identified 5 risk factors associated with recurrence: depth of tumor invasion (tumor penetration of the serosa[SE]-tumor invasion of adjacent structure[s SI]), lymphatic invasion( ly2-3), venous invasion( v2-3), budding( grade 2-3), and perineural invasion (PN1). Multivariate analysis identified 3 risk factors associated with recurrence: budding (grade 2-3; p=0.008), depth of tumor invasion( SE-SI; p=0.008), and venous invasion( v2-3; p=0.034).
  
  
  CONCLUSIONS
  The results of this study suggest that active postoperative adjuvant chemotherapy should be considered for the treatment of patients with stage II colorectal cancer with budding( grade 2-3), venous invasion( v2-3), or tumor depth of SE or SI.
authors.affiliation: Dept. of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine.
authors.forename: Motoi
authors.initials: M
authors.lastname: Koyama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Morita
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hashizume
authors.forename: Seiji
authors.initials: S
authors.lastname: Ito
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tohyama
authors.forename: Yukio
authors.initials: Y
authors.lastname: Inaba
authors.forename: Susumu
authors.initials: S
authors.lastname: Oishi
authors.forename: Hajime
authors.initials: H
authors.lastname: Morohashi
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Murata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
mesh_terms: D003082:Colectomy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors