title: Formulation and evaluation of Cyclosporin A emulgel for ocular delivery.
abstract: Emulgels have been extensively covered as a promising drug delivery system for the administration of lipophilic drugs. This work was conducted to develop an emulgel formulation for Cyclosporin A (CsA) employing polycarbophil as the gelling agent for ocular delivery. The prepared emulgels were evaluated for their physical appearance, rheological behavior, drug release, stability, precorneal clearance and irritation. Results showed that CsA emulgel formulations prepared with polycarbophil exhibited acceptable physical properties and drug release, which remained consistent after storage for 3 months. A prolonged retention time was also observed on the ocular surface with improved ocular bioavailability and no irritation. Therefore, the polycarbophil-based emulgel could be exploited as a potential hydrophobic drug carrier for topical ocular drug delivery.
authors.affiliation: a Department of Pharmaceutics , China Pharmaceutical University , Nanjing , China .
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.affiliation: a Department of Pharmaceutics , China Pharmaceutical University , Nanjing , China .
authors.forename: Xiang
authors.initials: X
authors.lastname: Ling
authors.affiliation: b Patent Examination Cooperation Center of SIPO , Jiangsu , Suzhou , China , and.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Jiang
authors.affiliation: a Department of Pharmaceutics , China Pharmaceutical University , Nanjing , China .
authors.forename: Shuang
authors.initials: S
authors.lastname: Du
authors.affiliation: c Department of Industrial Pharmacy, School of Chinese Pharmacy , Beijing University of TCM , Beijing , China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.affiliation: a Department of Pharmaceutics , China Pharmaceutical University , Nanjing , China .
authors.forename: Jiasheng
authors.initials: J
authors.lastname: Tu
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D060433:Administration, Ophthalmic; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016572:Cyclosporine / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004355:Drug Stability; D004356:Drug Storage; D004655:Emulsions; D005079:Excipients / Q000737:chemistry; D005782:Gels; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D011817:Rabbits; D012212:Rheology
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D004655:Emulsions; D005079:Excipients; D005782:Gels; D007166:Immunosuppressive Agents; D016572:Cyclosporine; C030312:calcium polycarbophil
keywords: Cyclosporin A; emulgel; ocular delivery; polycarbophil; precorneal clearance