title: Th1 immune response to H. pylori infection varies according to the age of the patients and influences the gastric inflammatory patterns.
abstract: To compare children and adults in respect to the effect of H. pylori infection on the gastric concentrations of cytokines linked to innate and Th1 immune response, as well as to investigate the changes in the gastric concentrations of the studied cytokines according to the age. We studied 245 children (142 H. pylori-negative and 103 H. pylori-positive) and 140 adults (40 H. pylori-negative and 100 H. pylori-positive). The gastric concentrations of cytokines representative of the innate and Th1 response were higher in the H. pylori-positive than in the -negative children and adults. The gastric concentrations of IL-1α and TNF-α were significantly higher, while those of IL-2, IL-12p70 and IFN-γ were lower in the infected children than in the infected adults. In the infected children, the gastric concentration of IL-1α, IL-2, IL-12p70 and IFN-γ increased, whereas in adults, the gastric concentrations of IFN-γ and IL-12p70 decreased with the aging. Increased gastric concentration of Th1 associated cytokines correlated with increased degree of gastritis that is the background lesion for the development of the H. pylori associated severe diseases. Concluding, Th1 response to H. pylori infection varies according to the age and seems to have determinant implication in the H. pylori infection outcomes.
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Departament of Microbiology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Fabrício
authors.initials: F
authors.lastname: Freire de Melo
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Gifone Aguiar
authors.initials: GA
authors.lastname: Rocha
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Andreia Maria Camargos
authors.initials: AM
authors.lastname: Rocha
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Kádima Nayara
authors.initials: KN
authors.lastname: Teixeira
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Silvia Helena Souza Pietra
authors.initials: SH
authors.lastname: Pedroso
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: João Bosco
authors.initials: JB
authors.lastname: Pereira Junior
authors.affiliation: Department of Pathology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Lúcia Porto
authors.initials: LP
authors.lastname: Fonseca de Castro
authors.affiliation: Department of Pathology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Brazil.
authors.forename: Mônica Maria Demas Álvares
authors.initials: MM
authors.lastname: Cabral
authors.affiliation: Endoscopy Service, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Simone Diniz
authors.initials: SD
authors.lastname: Carvalho
authors.affiliation: Endoscopy Service, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Paulo Fernando Souto
authors.initials: PF
authors.lastname: Bittencourt
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Celso Afonso
authors.initials: CA
authors.lastname: de Oliveira
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: dqueiroz@medicina.ufmg.br.
authors.forename: Dulciene Maria de Magalhães
authors.initials: DM
authors.lastname: Queiroz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000276:immunology* / Q000473:pathology*; D016481:Helicobacter Infections / Q000453:epidemiology / Q000276:immunology* / Q000473:pathology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018417:Th1 Cells / Q000276:immunology*; D055815:Young Adult
chemical_list: D016207:Cytokines
keywords: Adaptive immune response; Adults; Children; Cytokines; Helicobacter pylori; Innate immune response