title: Flavivirus entry receptors: an update.
abstract: Flaviviruses enter host cells by endocytosis initiated when the virus particles interact with cell surface receptors. The current model suggests that flaviviruses use at least two different sets of molecules for infectious entry: attachment factors that concentrate and/or recruit viruses on the cell surface and primary receptor(s) that bind to virions and direct them to the endocytic pathway. Here, we present the currently available knowledge regarding the flavivirus receptors described so far with specific attention to C-type lectin receptors and the phosphatidylserine receptors, T-cell immunoglobulin and mucin domain (TIM) and TYRO3, AXL and MER (TAM). Their role in flavivirus attachment and entry as well as their implication in the virus biology will be discussed in depth.
authors.affiliation: INSERM U944, CNRS 7212, Laboratoire de Pathologie et Virologie Moléculaire, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris 75010, France. manuel.perera@inserm.fr.
authors.forename: Manuel
authors.initials: M
authors.lastname: Perera-Lecoin
authors.affiliation: INSERM U944, CNRS 7212, Laboratoire de Pathologie et Virologie Moléculaire, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris 75010, France. laurent.meertens@inserm.fr.
authors.forename: Laurent
authors.initials: L
authors.lastname: Meertens
authors.affiliation: INSERM U944, CNRS 7212, Laboratoire de Pathologie et Virologie Moléculaire, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris 75010, France. xavier.carnec@gmail.com.
authors.forename: Xavier
authors.initials: X
authors.lastname: Carnec
authors.affiliation: INSERM U944, CNRS 7212, Laboratoire de Pathologie et Virologie Moléculaire, Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris 75010, France. ali.amara@inserm.fr.
authors.forename: Ali
authors.initials: A
authors.lastname: Amara
mesh_terms: D000818:Animals; D004705:Endocytosis; D005416:Flavivirus / Q000502:physiology*; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D053585:Virus Attachment; D053586:Virus Internalization
chemical_list: D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D011991:Receptors, Virus; C408123:phosphatidylserine receptor