title: Esophageal actinomycosis in a patient with end-stage renal disease.
abstract: Actinomycosis of esophagus is uncommon. Herpes simplex virus, cytomegalovirus, candidiasis, tuberculosis, and other fungal infections are the commonly reported infections in both immunocompromised and immunocompetent patients. We report a case of esophageal actinomycosis in an end-stage renal disease patient. A 28-year-old lady, known case of systemic lupus erythematosus, hepatitis B virus infection with end-stage renal disease on regular maintenance hemodialysis since 5 years presented with history of epigastric pain and odynophagia for 1 week. Her upper gastrointestinal endoscopic examination revealed extensive necrotic areas with membrane in the esophagus. Histopathology revealed actinomycotic colonies and bacterial clumps. She was treated with intravenous penicillin followed by oral ampicillin for 6 months. She showed marked clinical improvement, and repeat endoscopy showed healing of ulceration and no evidence of actinomycosis.
authors.affiliation: Department of Nephrology, Kasturba Medical College, Manipal University, Manipal, India.
authors.forename: Shankar Prasad
authors.initials: SP
authors.lastname: Nagaraju
authors.forename: Dilip Ashok
authors.initials: DA
authors.lastname: Kirpalani
authors.forename: Aditya S
authors.initials: AS
authors.lastname: Bhabhe
authors.forename: Raghvendra
authors.initials: R
authors.lastname: Prasad
authors.forename: Hardik
authors.initials: H
authors.lastname: Shah
authors.forename: Ashok L
authors.initials: AL
authors.lastname: Kirpalani
mesh_terms: D000190:Actinomyces / Q000302:isolation & purification; D000196:Actinomycosis / Q000209:etiology* / Q000473:pathology*; D000328:Adult; D004935:Esophageal Diseases / Q000382:microbiology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000382:microbiology* / Q000628:therapy; D006435:Renal Dialysis
keywords: Esophageal actinomycosis; end-stage renal disease; immunocompromised state