title: Recommendations for management of patients with neuroendocrine liver metastases.
abstract: Many management strategies exist for neuroendocrine liver metastases. These strategies range from surgery to ablation with various interventional radiology procedures, and include both regional and systemic therapy with diverse biological, cytotoxic, or targeted agents. A paucity of biological, molecular, and genomic information and an absence of data from rigorous trials limit the validity of many publications detailing management. This Review represents the views from an international conference, for which 15 expert working groups prepared evidence-based assessments addressing specific questions, and from which an independent jury derived final recommendations. The aim of the conference was to review the existing approaches to neuroendocrine liver metastases, assess the evidence on which management decisions were based, develop internationally acceptable recommendations for clinical practice (when evidence was available), and make recommendations for clinical and research endeavours. This report represents the final clinical statements and proposals for future research.
authors.affiliation: Imperial College London, London, UK.
authors.forename: Andrea
authors.initials: A
authors.lastname: Frilling
authors.affiliation: Yale University, New Haven, Connecticut, USA. Electronic address: imodlin@optonline.net.
authors.forename: Irvin M
authors.initials: IM
authors.lastname: Modlin
authors.affiliation: Yale University, New Haven, Connecticut, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Kidd
authors.affiliation: University College London, London, UK.
authors.forename: Christopher
authors.initials: C
authors.lastname: Russell
authors.affiliation: University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Breitenstein
authors.affiliation: Northwestern University Chicago, Chicago, USA.
authors.forename: Riad
authors.initials: R
authors.lastname: Salem
authors.affiliation: Erasmus Medical Center, Rotterdam, Netherlands.
authors.forename: Dik
authors.initials: D
authors.lastname: Kwekkeboom
authors.affiliation: Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Wan-yee
authors.initials: WY
authors.lastname: Lau
authors.affiliation: IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.affiliation: Hôpital Beaujon, Clichy, Paris, France.
authors.forename: Valerie
authors.initials: V
authors.lastname: Vilgrain
authors.affiliation: University College London, London, UK.
authors.forename: Brian
authors.initials: B
authors.lastname: Davidson
authors.affiliation: University of Chicago, Chicago, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Siegler
authors.affiliation: University College London, London, UK; Royal Free Hospital, London, UK.
authors.forename: Martyn
authors.initials: M
authors.lastname: Caplin
authors.affiliation: IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Solcia
authors.affiliation: American Society of Clinical Oncology, Alexandria, VA, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Schilsky
mesh_terms: D001706:Biopsy; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy*; D020360:Neoadjuvant Therapy; D009360:Neoplastic Cells, Circulating; D018358:Neuroendocrine Tumors / Q000473:pathology / Q000556:secondary* / Q000628:therapy*