title: Anti-HIV-1 activities of extracts and phenolics from Smilax china L.
abstract: Four extracts (EtOH, CHCl3, EtOAc, and BuOH) and five phenolics (dihydrokaempferol (1), resveratrol (2), kaempferol-7-O-β-D-glucoside (3), dihydrokaempferol-3-O-α-L-rhamnoside (4), oxyresveratrol (5)) from Smilax china L. was evaluated for anti-HIV-1 activities and cytotoxicity activities in vitro. All these extracts and phenolics showed lower or no cytotoxicity at a concentration ranged from 0.8 μg/mL to 100 μg/mL, but some showed potential anti-HIV-1 activities, that is, BuOH extract and compound 2 showed higher anti-HIV-1 activities than other extracts and compounds in the tested concentrations. EtOAc extract and compound 1 and 3 showed moderate anti-HIV-1 activities at a concentration higher than 4 μg/mL. In the end, the structure-activity relationship of four extracts and five phenolics was discussed.
authors.affiliation: School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing China.
authors.forename: Wei-Xin
authors.initials: WX
authors.lastname: Wang
authors.affiliation: School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing China.
authors.forename: Jing-Yi
authors.initials: JY
authors.lastname: Qian
authors.affiliation: School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Wang
authors.affiliation: Key Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, China.
authors.forename: Ai-Ping
authors.initials: AP
authors.lastname: Jiang
authors.affiliation: School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing China.
authors.forename: Ai-Qun
authors.initials: AQ
authors.lastname: Jia
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D057809:HEK293 Cells; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D032281:Smilax; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D010636:Phenols; D010936:Plant Extracts