title: HTS navigator: freely accessible cheminformatics software for analyzing high-throughput screening data.
abstract: CONCLUSIONS
  We report on the development of the high-throughput screening (HTS) Navigator software to analyze and visualize the results of HTS of chemical libraries. The HTS Navigator processes output files from different plate readers' formats, computes the overall HTS matrix, automatically detects hits and has different types of baseline navigation and correction features. The software incorporates advanced cheminformatics capabilities such as chemical structure storage and visualization, fast similarity search and chemical neighborhood analysis for retrieved hits. The software is freely available for academic laboratories.
  
  
  METHODS
  http://fourches.web.unc.edu/
authors.affiliation: Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill and Department of Pharmacology and the NIMH Psychoactive Drug Screening Program, School of Medicine, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA.
authors.forename: Denis
authors.initials: D
authors.lastname: Fourches
authors.forename: Maria F
authors.initials: MF
authors.lastname: Sassano
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
authors.forename: Alexander
authors.initials: A
authors.lastname: Tropsha
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D062126:Databases, Chemical; D055808:Drug Discovery; D057166:High-Throughput Screening Assays; D016247:Information Storage and Retrieval; D021281:Quantitative Structure-Activity Relationship; D054852:Small Molecule Libraries / Q000494:pharmacology*; D012984:Software
chemical_list: D054852:Small Molecule Libraries