title: Isavuconazole treatment of a patient with disseminated mucormycosis.
abstract: We report a patient with relapsed acute myelogenous leukemia after allogeneic stem cell transplantation who developed disseminated mucormycosis due to Rhizomucor pusillus/R. miehei involving lung, brain, and skin. After failing posaconazole and being intolerant to amphotericin, he was treated effectively with isavuconazole for over 6 months despite ongoing treatment for relapsed leukemia.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Driele
authors.initials: D
authors.lastname: Peixoto
authors.forename: Lisa S
authors.initials: LS
authors.lastname: Gagne
authors.forename: Sarah P
authors.initials: SP
authors.lastname: Hammond
authors.forename: Erin T
authors.initials: ET
authors.lastname: Gilmore
authors.forename: Amy C
authors.initials: AC
authors.lastname: Joyce
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Soiffer
authors.forename: Francisco M
authors.initials: FM
authors.lastname: Marty
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001921:Brain / Q000382:microbiology / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000628:therapy; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D009570:Nitriles / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D020103:Rhizomucor / Q000302:isolation & purification*; D012867:Skin / Q000382:microbiology / Q000473:pathology; D033581:Stem Cell Transplantation / Q000009:adverse effects; D014184:Transplantation, Homologous / Q000009:adverse effects; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D009570:Nitriles; D011725:Pyridines; D014230:Triazoles; C508735:isavuconazole