title: Detection of infectivity in blood of persons with variant and sporadic Creutzfeldt-Jakob disease.
abstract: We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to those reported in various animals with transmissible spongiform encephalopathies.
authors.forename: Jean Yves
authors.initials: JY
authors.lastname: Douet
authors.forename: Saima
authors.initials: S
authors.lastname: Zafar
authors.forename: Armand
authors.initials: A
authors.lastname: Perret-Liaudet
authors.forename: Caroline
authors.initials: C
authors.lastname: Lacroux
authors.forename: Séverine
authors.initials: S
authors.lastname: Lugan
authors.forename: Naima
authors.initials: N
authors.lastname: Aron
authors.forename: Herve
authors.initials: H
authors.lastname: Cassard
authors.forename: Claudia
authors.initials: C
authors.lastname: Ponto
authors.forename: Fabien
authors.initials: F
authors.lastname: Corbière
authors.forename: Juan Maria
authors.initials: JM
authors.lastname: Torres
authors.forename: Inga
authors.initials: I
authors.lastname: Zerr
authors.forename: Olivier
authors.initials: O
authors.lastname: Andreoletti
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002417:Cattle; D007562:Creutzfeldt-Jakob Syndrome / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D011328:Prions / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity
chemical_list: D011328:Prions
keywords: CJD; Creutzfeldt-Jakob disease; TSE; blood; infectivity; prions; sCJD; transmissible spongiform encephalopathy; vCJD