title: CuO nanosheets-enhanced flow-injection chemiluminescence system for determination of vancomycin in water, pharmaceutical and human serum.
abstract: A novel, rapid and sensitive CuO nanosheets (NSs) amplified flow-injection chemiluminescence (CL) system, luminol-H2O2-CuO nanosheets, was developed for determination of the vancomycin hydrochloride for the first time. It was found that vancomycin could efficiently inhibit the CL intensity of luminol-H2O2-CuO nanosheets system in alkaline medium. Under the optimum conditions, the inhibited CL intensity was linearly proportional to the concentration of vancomycin over the ranges of 0.5-18.0 and 18.0-40.0 mg L(-1), with a detection limit (3σ) of 0.1 mg L(-1). The precision was calculated by analyzing samples containing 5.0 mg L(-1) vancomycin (n=11) and the relative standard deviation (RSD) was 2.8%. Also, a high injection throughput of 120 sample h(-1) was obtained. The CuO nanosheets were synthesized by a sonochemical method. Also, X-ray diffraction (XRD) and scanning electron microscopy (SEM) analyses were employed to characterize the CuO nanosheets. The method was successfully employed to determine vancomycin hydrochloride in environmental water samples, pharmaceutical formulation and spiked human serum.
authors.affiliation: Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran. Electronic address: a_khataee@tabrizu.ac.ir.
authors.forename: A R
authors.initials: AR
authors.lastname: Khataee
authors.affiliation: Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Hasanzadeh
authors.affiliation: Department of Chemistry, Faculty of Science, University of Maragheh, Maragheh, East Azerbaijan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Iranifam
authors.affiliation: Research Laboratory of Advanced Water and Wastewater Treatment Processes, Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Fathinia
authors.affiliation: School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749, South Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Hanifehpour
authors.affiliation: School of Mechanical Engineering, Yeungnam University, Gyeongsan 712-749, South Korea. Electronic address: swjoo@yu.ac.kr.
authors.forename: S W
authors.initials: SW
authors.lastname: Joo
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000097:blood*; D003300:Copper / Q000737:chemistry*; D017022:Flow Injection Analysis / Q000379:methods; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry; D057230:Limit of Detection; D008163:Luminescent Measurements / Q000379:methods; D008165:Luminol / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry; D014640:Vancomycin / Q000032:analysis* / Q000097:blood*; D014867:Water / Q000032:analysis; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D004364:Pharmaceutical Preparations; D014867:Water; D008165:Luminol; D014640:Vancomycin; D003300:Copper; D006861:Hydrogen Peroxide; C030973:cupric oxide
keywords: CuO nanosheets; Flow-chemiluminescence; Luminol; Sonochemical; Vancomycin