title: Effect of nebivolol treatment on atherosclerotic plaque components in apoE-knockout mice.
abstract: Nebivolol, a third generation beta1-blocker was previously found to reduce the size of atherosclerotic lesions. The aim of this study was to assess the effect of orally administered nevibolol on the components of the atherosclerotic plaque in apoE-deficient mice. The quantitative evaluation of cross-sectioned plaques stained by histological and immunohistochemical techniques revealed that treatment with nebivolol (2.0 μol per kg b.w.) for 4 months caused a decrease in the necrotic core area (by 46%, p=0.03), density of CD68+ macrophages (by 41%, p=0.008) and CD3+ lymphocytes (by 16%, p=0.03), collagen content (by 49%, p=0.008) and the activity area of metalloproteinases (by 48%, p=0.008), as well as an increase in the smooth muscle content of the fibromuscular cap (by 46%, p=0.008). These effects suggest that nebivolol suppresses the inflammatory/immune processes in the plaque and enhances its stability.
authors.affiliation: Department of Histology, Jagiellonian University Medical College, Cracow, Poland. gpfosciak@cm-uj.krakow.pl.
authors.forename: G
authors.initials: G
authors.lastname: Pyka-Fosciak
authors.forename: J
authors.initials: J
authors.lastname: Jawien
authors.forename: M
authors.initials: M
authors.lastname: Gajda
authors.forename: E
authors.initials: E
authors.lastname: Jasek
authors.forename: J A
authors.initials: JA
authors.lastname: Litwin
mesh_terms: D000199:Actins / Q000378:metabolism; D058671:Adrenergic beta-1 Receptor Antagonists / Q000494:pharmacology*; D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology; D001057:Apolipoproteins E / Q000172:deficiency / Q000235:genetics; D001578:Benzopyrans / Q000494:pharmacology*; D017252:CD3 Complex / Q000276:immunology; D003094:Collagen / Q000378:metabolism; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D008264:Macrophages / Q000276:immunology; D020782:Matrix Metalloproteinases / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D032389:Myocytes, Smooth Muscle; D000068577:Nebivolol; D058226:Plaque, Atherosclerotic / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D000097382:CD68 Molecule
chemical_list: D000199:Actins; D058671:Adrenergic beta-1 Receptor Antagonists; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D001057:Apolipoproteins E; D001578:Benzopyrans; D017252:CD3 Complex; D003094:Collagen; D004983:Ethanolamines; D020782:Matrix Metalloproteinases; D000068577:Nebivolol; C081026:CD68 protein, mouse; D000097382:CD68 Molecule