title: Expression of matriptase correlates with tumour progression and clinical prognosis in oral squamous cell carcinoma.
abstract: OBJECTIVE
  To investigate the relationship of matriptase expression in oral squamous cell carcinoma (OSCC) to clinicopathological characteristics, patient survival and cell-invasive properties.
  
  
  RESULTS
  Matriptase expression in OSCC was evaluated by immunohistochemical staining, and its relationship to clinicopathological features and outcomes was assessed statistically. The shRNA-mediated stable knockdown of matriptase in OSCC cells was used to analyse cell proliferation, migration and invasion in vitro. Matriptase immunostaining score was correlated with histopathological grade, clinical stage, positive lymph node and distant metastasis, and higher matriptase immunostaining score was associated significantly with poor prognosis. Elevated matriptase expression in oral cancer cell lines was a significant promoter of oral cancer cell migration and invasion.
  
  
  CONCLUSIONS
  Matriptase expression correlates with tumour progression and invasive capability in OSCC and may be an adverse prognostic marker for this cancer.
authors.affiliation: Institute of Oral Biology, School of Dentistry, National Yang-Ming University, Taipei, Taiwan; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Division of Histological and Clinical Pathology, Hualien Armed Forced General Hospital, Hualien, Taiwan.
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Cheng
authors.forename: Mao-Suan
authors.initials: MS
authors.lastname: Huang
authors.forename: Chun-Shu
authors.initials: CS
authors.lastname: Lin
authors.forename: Li-Han
authors.initials: LH
authors.lastname: Lin
authors.forename: Herng-Sheng
authors.initials: HS
authors.lastname: Lee
authors.forename: Jhih-Cheng
authors.initials: JC
authors.lastname: Jiang
authors.forename: Kan-Tai
authors.initials: KT
authors.lastname: Hsia
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D015153:Blotting, Western; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000401:mortality / Q000473:pathology*; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation / Q000502:physiology; D018450:Disease Progression; D005260:Female; D055785:Gene Knockdown Techniques; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000201:enzymology / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D016016:Proportional Hazards Models; D034741:RNA, Small Interfering; D012697:Serine Endopeptidases / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D034741:RNA, Small Interfering; D012697:Serine Endopeptidases; C485595:matriptase
keywords: matriptase; oral squamous cell carcinoma