title: The multitarget drug approach in migraine treatment: the new challenge to conquer.
abstract: Migraine is a complex neurovascular disorder where a complex and interrelated neuronal spinal, supraspinal and central mechanisms are involved. Although we have greatly advanced in the knowledge of the main pathways involved in this disorder, the current drugs used are not effective in all patients, suggesting that the key mechanism related to headache relief remains elusive. In this context, the multi-target drug approach or network pharmacology emerges as a new step in the development of innovative migraine pharmacotherapy. The design, discovery, and development of new drugs that reach several (instead of unique) specific targets (functional selectivity) involved in the migraine pathophysiology is essential to progress in the migraine treatment and open a new field of study about the main pathways and targets that could synergistically improve the migraine management.
authors.affiliation: Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Queretaro, Mexico.
authors.forename: Abimael
authors.initials: A
authors.lastname: González-Hernández
authors.forename: Miguel
authors.initials: M
authors.lastname: Condés-Lara
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy* / Q000378:metabolism; D052248:Nitric Oxide Synthase Type I / Q000037:antagonists & inhibitors* / Q000378:metabolism; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D017366:Serotonin Receptor Agonists; D052248:Nitric Oxide Synthase Type I
keywords: functional selectivity; network pharmacology; pharmacotherapy