title: [Research advances on thogoto virus of the family orthomyxoviridae].
abstract: Thogoto virus belongs to the family Orthomyxoviridae. It is a tick-borne arbovirus that can infect both human and animals. Thogoto virus's genetic constitution, replication and transcription, and the function of the translated proteins are similar to influenza virus. The studies on Thogoto virus are important for us to better understand the conservative sites of influenza virus. Moreover, the animal model of Thogo-to virus is expected to be an alternative model for highly pathogenic influenza viruses. In the past years, Thogoto virus attracted limited public attention and few studies were engaged in this area. The classification of Thogoto virus, the genetic constitution and evolution, and viral proteins were included in this review. The functions of M protein and ML protein were emphasized, which were translated from the sixth segment and played an important role in viral replication, the interaction between Thogoto virus and host were also highlighted.
authors.affiliation: National Institute for Viral Disease Control and Prevention World Health Organization Collaborating Centre for Reference and Research on Influenza Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention Beijing 102206, China. zengxiaoxu@cnic.org.cn
authors.forename: Xiao-xu
authors.initials: XX
authors.lastname: Zeng
authors.affiliation: National Institute for Viral Disease Control and Prevention World Health Organization Collaborating Centre for Reference and Research on Influenza Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention Beijing 102206, China.
authors.forename: Da-yan
authors.initials: DY
authors.lastname: Wang
authors.affiliation: National Institute for Viral Disease Control and Prevention World Health Organization Collaborating Centre for Reference and Research on Influenza Key Laboratory of Surveillance and Early-warning on Infectious Disease, Chinese Center for Disease Control and Prevention Beijing 102206, China.
authors.forename: Yue-long
authors.initials: YL
authors.lastname: Shu
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000639:trends; D054884:Host-Pathogen Interactions; D006801:Humans; D009976:Orthomyxoviridae Infections / Q000821:virology*; D018117:Thogotovirus / Q000145:classification / Q000235:genetics / Q000502:physiology*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014779:Virus Replication
chemical_list: D014764:Viral Proteins