title: Genetic associations between intelligence and cortical thickness emerge at the start of puberty.
abstract: Cognitive abilities are related to (changes in) brain structure during adolescence and adulthood. Previous studies suggest that associations between cortical thickness and intelligence may be different at different ages. As both intelligence and cortical thickness are heritable traits, the question arises whether the association between cortical thickness development and intelligence is due to genes influencing both traits. We study this association in a longitudinal sample of young twins. Intelligence was assessed by standard IQ tests at age 9 in 224 twins, 190 of whom also underwent structural magnetic resonance imaging (MRI). Three years later at age 12, 177/125 twins returned for a follow-up measurement of intelligence/MRI scanning, respectively. We investigated whether cortical thickness was associated with intelligence and if so, whether this association was driven by genes. At age 9, there were no associations between cortical thickness and intelligence. At age 12, a negative relationship emerged. This association was mainly driven by verbal intelligence, and manifested itself most prominently in the left hemisphere. Cortical thickness and intelligence were explained by the same genes. As a post hoc analysis, we tested whether a specific allele (rs6265; Val66Met in the BDNF gene) contributed to this association. Met carriers showed lower intelligence and a thicker cortex, but only the association between the BDNF genotype and cortical thickness in the left superior parietal gyrus reached significance. In conclusion, it seems that brain areas contributing to (verbal) intellectual performance are specializing under the influence of genes around the onset of puberty.
authors.affiliation: Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Brouwer
authors.forename: Inge L C
authors.initials: IL
authors.lastname: van Soelen
authors.forename: Suzanne C
authors.initials: SC
authors.lastname: Swagerman
authors.forename: Hugo G
authors.initials: HG
authors.lastname: Schnack
authors.forename: Erik A
authors.initials: EA
authors.lastname: Ehli
authors.forename: René S
authors.initials: RS
authors.lastname: Kahn
authors.forename: Hilleke E
authors.initials: HE
authors.lastname: Hulshoff Pol
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
mesh_terms: D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000254:growth & development*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D005838:Genotype; D006801:Humans; D007360:Intelligence; D007361:Intelligence Tests; D007802:Language; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D008957:Models, Genetic; D009929:Organ Size; D011627:Puberty; D012042:Registries
chemical_list: D019208:Brain-Derived Neurotrophic Factor; C579455:BDNF protein, human
keywords: adolescence; cerebral cortex; genetic associations; intelligence; twins