title: Imaging the inside of a tumour: a review of radionuclide imaging and theranostics targeting intracellular epitopes.
abstract: Molecular imaging of tumour tissue focusses mainly on extracellular epitopes such as tumour angiogenesis or signal transduction receptors expressed on the cell membrane. However, most biological processes that define tumour phenotype occur within the cell. In this mini-review, an overview is given of the various techniques to interrogate intracellular events using molecular imaging with radiolabelled compounds. Additionally, similar targeting techniques can be employed for radionuclide therapy using Auger electron emitters, and recent advances in Auger electron therapy are discussed.
authors.affiliation: MRC/CRUK Gray Institute for Radiation Oncology and Biology, Department of Oncology, University of Oxford, UK.
authors.forename: Bart
authors.initials: B
authors.lastname: Cornelissen
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000000981:diagnostic imaging / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D042541:Intracellular Space / Q000000981:diagnostic imaging / Q000276:immunology*; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D011877:Radionuclide Imaging / Q000379:methods*
chemical_list: D000939:Epitopes
keywords: Auger electron; PET; SPECT; cell penetrating peptide; molecular imaging; nuclear localisation sequence