title: Biocompatible and high-performance amino acids-capped MnWO4 nanocasting as a novel non-lanthanide contrast agent for X-ray computed tomography and T(1)-weighted magnetic resonance imaging.
abstract: In the present work, a novel non-lanthanide dual-modality contrast agent, manganese tungstate (MnWO4), has been successfully constructed by a facile and versatile hydrothermal route. With the merits of a high atomic number and a well-positioned K-edge energy of tungsten, our well-prepared non-lanthanide nanoprobes provide a higher contrast efficacy than routine iodine-based agents in clinics. Additionally, the presence of Mn in these nanoparticles endow them with excellent T1-weighted MR imaging capabilities. As an alternative to T2-weighted MRI and CT dual-modality contrast agents, the nanoprobes can provide a positive contrast signal, which prevents confusion with the dark signals from hemorrhage and blood clots. To the best of our knowledge, this is the first report that a non-lanthanide imaging nanoprobe is applied for CT and T1-weighted MRI simultaneously. Moreover, comparing with gadolinium-based T1-weighted MRI and CT dual-modality contrast agents that were associated with nephrogenic systemic fibrosis (NSF), our contrast agents have superior biocompatibility, which is proved by a detailed study of the pharmacokinetics, biodistribution, and in vivo toxicology. Together with excellent dispersibility, high biocompatibility and superior contrast efficacy, these nanoprobes provide detailed and complementary information from dual-modality imaging over traditional single-mode imaging and bring more opportunities to the new generation of non-lanthanide nanoparticulate-based contrast agents.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Changchun, 130022, China. jren@ciac.jl.cn xqu@ciac.ac.cn.
authors.forename: Kai
authors.initials: K
authors.lastname: Dong
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Liu
authors.forename: Sa
authors.initials: S
authors.lastname: Huang
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Li
authors.forename: Qinghai
authors.initials: Q
authors.lastname: Yuan
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000494:pharmacology; D003287:Contrast Media / Q000737:chemistry / Q000494:pharmacology; D057809:HEK293 Cells; D006801:Humans; D008279:Magnetic Resonance Imaging; D017895:Manganese Compounds / Q000737:chemistry / Q000494:pharmacology; D008422:Materials Testing; D054989:Nephrogenic Fibrosing Dermopathy / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D017973:Tungsten Compounds / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D003287:Contrast Media; D017895:Manganese Compounds; D017973:Tungsten Compounds