title: Nutrition and pancreatic cancer.
abstract: BACKGROUND
  Pancreatic cancer is the fourth leading cause of cancer death in men and women. Prognosis is poor with a 5-year survival rate of less than 5%. As there is no effective screening modality, the best way to reduce morbidity and mortality due to pancreatic cancer is by effective primary prevention.
  
  
  OBJECTIVE
  To evaluate the role of dietary components in pancreatic cancer.
  
  
  METHODS
  Bibliographical searches were performed in PubMed using the terms "pancreatic cancer", together with "nutrition", "diet", "dietary factors", "lifestyle", "smoking", "alcohol" and "epidemiology".
  
  
  RESULTS
  Fruits (particularly citrus) and vegetable consumption may be beneficial. The consumption of whole grains has been shown to reduce pancreatic cancer risk and fortification of whole grains with folate may confer further protection. Red meat, cooked at high temperatures, should be avoided, and replaced with poultry or fish. Total fat should be reduced. The use of curcumin and other flavonoids should be encouraged in the diet. There is no evidence for benefit from vitamin D supplementation. There may be benefit for dietary folate. Smoking and high Body Mass Index have both been inversely associated with pancreatic cancer risk.
  
  
  CONCLUSIONS
  The lack of randomized trials and the presence of confounding factors including smoking status, physical activity, distance of habitat from the equator, obesity, and diabetes may often result in inconclusive results. There is evidence to encourage the use of whole grain in the staple diet and supplementation within the diet of folate, curcumin and other flavanoids. Carefully designed randomized trials are required to further elucidate these important matters.
authors.affiliation: Department of Gastroenterology, Royal Free Hospital, Pond Street, London, NW3 2QG, U.K. m.caplin@ucl.ac.uk.
authors.forename: Marinos
authors.initials: M
authors.lastname: Pericleous
authors.forename: Roberta Elisa
authors.initials: RE
authors.lastname: Rossi
authors.forename: Dalvinder
authors.initials: D
authors.lastname: Mandair
authors.forename: Tara
authors.initials: T
authors.lastname: Whyand
authors.forename: Martyn Evan
authors.initials: ME
authors.lastname: Caplin
mesh_terms: D000818:Animals; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D008297:Male; D009752:Nutritional Status; D010190:Pancreatic Neoplasms / Q000517:prevention & control*
keywords: Pancreatic cancer; alcohol; carcinogenesis; diet; dietary factors; epidemiology; lifestyle; nutrition; review; smoking