title: Cytotoxic and Antimicrobial Napyradiomycins from Two Marine-Derived, MAR 4StreptomycesStrains.
abstract: Cancer cell cytotoxicity-guided fractionation of the acetone extracts of two cultured marine-derivedStreptomycesstrains belonging to the MAR4 group yielded six new napyradiomycins, compounds A-F (1-6), together with three known compounds, napyradiomycins B2-B4 (7-9). Napyradiomycins1-4are new members of the napyradiomycin "C type" meroterpenoids that possess a linear monoterpene moiety bridging between C-7 and C-10a. Compound4has an additional tetrahydropyran ring fused to the phenol moiety. Compounds5-9are related to the napyradiomycin "B type" meroterpenoids. The structures of all new compounds were assigned by interpretation of 1D and 2D NMR, MS and other spectroscopic data. The relative configurations were assigned based upon interpretation of ROESY 2D NMR experiments. The cytotoxicity of1-9against the human colon carcinoma cell line HCT-116, and their antibacterial activities against Methicillin-resistantStaphylococcus aureus(MRSA) are presented.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 USA, , Homepage: http://sio.ucsd.edu/Profile/wfenical.
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 USA, , Homepage: http://sio.ucsd.edu/Profile/wfenical.
authors.forename: Paul R
authors.initials: PR
authors.lastname: Jensen
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093-0204 USA, , Homepage: http://sio.ucsd.edu/Profile/wfenical.
authors.forename: William
authors.initials: W
authors.lastname: Fenical
keywords: antibiotics; cancer cell cytotoxicity; dihydronaphthoquinones; halogenated terpenoids; meroterpenoids; mixed biosynthesis; napyradiomycins