title: Salmonella antigen induces differential bone marrow cytokine secretion in control and malnourished rats.
abstract: Balanced diet fed (BDF) rats injected with Salmonella typhi 'H' antigen showed an initial suppression of an immunomodulatory bone marrow cytokine Frl (BM-Frl) followed by stimulation, whereas the cytokine secretory pattern showed only stimulation in immunized vitamin B complex malnourished rats. This nutritional-dependent differential response of a bone marrow cytokine to antigen is similar to that observed previously in brain adenosine triphosphatase (ATPase) function following immunization. An improvement in antibody response to S. typhi (p<0.01) and neutrophil function (p<0.05) was observed in cytokine-treated malnourished immunosuppressed rats further strengthening our previous observations that BM-Frl modulates both specific and non-specific immune systems. No significant change was observed in BDF animals indicating that malnourished rats gain more from cytokine therapy, whereas a negative feedback system might be present in BDF animals.
authors.affiliation: Department of Chemistry, Bose Institute, Calcutta, India.
authors.forename: D
authors.initials: D
authors.lastname: Ghosal
authors.forename: S
authors.initials: S
authors.lastname: Dutta
authors.forename: P
authors.initials: P
authors.lastname: Bhattacharyya