title: Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections.
abstract: The Sabin Vaccine Institute Product Development Partnership is developing a Pan-anthelmintic vaccine that simultaneously targets the major soil-transmitted nematode infections, in other words, ascariasis, trichuriasis and hookworm infection. The approach builds off the current bivalent Human Hookworm Vaccine now in clinical development and would ultimately add both a larval Ascaris lumbricoides antigen and an adult-stage Trichuris trichiura antigen from the parasite stichosome. Each selected antigen would partially reproduce the protective immunity afforded by UV-attenuated Ascaris eggs and Trichuris stichosome extracts, respectively. Final antigen selection will apply a ranking system that includes the evaluation of expression yields and solubility, feasibility of process development and the absence of circulating antigen-specific IgE among populations living in helminth-endemic regions. Here we describe a five year roadmap for the antigen discovery, feasibility and antigen selection, which will ultimately lead to the scale-up expression, process development, manufacture, good laboratory practices toxicology and preclinical evaluation, ultimately leading to Phase 1 clinical testing.
authors.affiliation: Sabin Vaccine Institute and Texas Children's Hospital Center for Vaccine Development, National School of Tropical Medicine, Baylor College of Medicine , Houston, TX , USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhan
authors.forename: Coreen M
authors.initials: CM
authors.lastname: Beaumier
authors.forename: Neima
authors.initials: N
authors.lastname: Briggs
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Jones
authors.forename: Brian P
authors.initials: BP
authors.lastname: Keegan
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Bottazzi
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Hotez
mesh_terms: D000723:Ancylostomatoidea / Q000276:immunology; D000818:Animals; D000871:Anthelmintics; D000947:Antigens, Helminth / Q000276:immunology; D001196:Ascariasis / Q000276:immunology / Q000517:prevention & control*; D017164:Ascaris lumbricoides / Q000276:immunology; D006725:Hookworm Infections / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D016052:Protozoan Vaccines / Q000276:immunology*; D012987:Soil / Q000469:parasitology; D014257:Trichuriasis / Q000276:immunology / Q000517:prevention & control*; D014258:Trichuris / Q000276:immunology
chemical_list: D000871:Anthelmintics; D000947:Antigens, Helminth; D016052:Protozoan Vaccines; D012987:Soil