title: Determinants of quality of life in children with cerebral palsy: a comprehensive biopsychosocial approach.
abstract: This study investigated the determinants of quality of life (QOL) of children with cerebral palsy (CP) considering possible variables comprehensively from a biopsychosocial perspective by adopting the International Classification of Functioning, Disability and Health (ICF) and using a CP-specific QOL questionnaire. A total of 167 children with CP (mean age 9.06 years, SD 2.61 years) and their caregivers participated in this study. Children's QOL was measured by the Cerebral Palsy Quality of Life for Children (CP QOL-Child) - primary caregiver proxy-report form. The potential determinants of QOL were collected based on all ICF dimensions. Results of seven multiple regression models showed that the determinants of QOL in children with CP were multidimensional and biopsychosocial in nature, i.e., encompassing the domains of health condition, body functions and structures, and contextual factors of the ICF. Children's behavioral and emotional problems as well as caregiver's psychological and family-related factors were important determinants of QOL in children with CP. Knowledge of the determinants of QOL could serve as a guide in a holistic approach to evaluation and intervention targeted at these determinants to improve the QOL of children with CP.
authors.affiliation: School of Occupational Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Physical Medicine and Rehabilitation, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Kuan-Lin
authors.initials: KL
authors.lastname: Chen
authors.affiliation: School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: mhtseng@ntu.edu.tw.
authors.forename: Mei-Hui
authors.initials: MH
authors.lastname: Tseng
authors.affiliation: Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Jeng-Yi
authors.initials: JY
authors.lastname: Shieh
authors.affiliation: Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.affiliation: School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei, Taiwan.
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Huang
mesh_terms: D000223:Adaptation, Psychological; D017028:Caregivers; D002547:Cerebral Palsy / Q000523:psychology*; D002648:Child; D002653:Child Behavior Disorders / Q000523:psychology; D005191:Family Characteristics; D005260:Female; D006304:Health Status; D006801:Humans; D016014:Linear Models; D008297:Male; D051346:Mobility Limitation; D015999:Multivariate Analysis; D019727:Proxy; D011788:Quality of Life; D012720:Severity of Illness Index; D012737:Sex Factors; D058992:Social Participation; D011795:Surveys and Questionnaires
keywords: Cerebral palsy; Determinants; ICF; Quality of life