title: Subfoveal choroidal thickness in preeclampsia: comparison with normal pregnant and nonpregnant women.
abstract: OBJECTIVE
  To compare the subfoveal choroidal thickness (SFCT) in preeclampsia, normal pregnancy, and non-pregnant women using enhanced depth imaging optical coherence tomography (EDI-OCT).
  
  
  METHODS
  One hundred nineteen volunteers were enrolled in this prospective and comparative study. The participants were divided into three groups: group 1 (33 preeclamptic women), group 2 (46 normal pregnant), and group 3 (40 non-pregnant healthy women). The SFCT was measured by EDI-OCT. The refractive error, intraocular pressure (IOP), axial length (AL), central corneal thickness (CCT), systolic and diastolic blood pressure, and ocular perfusion pressure (OPP) were also measured. Medical records of pregnant women, including gestational age, maternal weight gain, weight, and proteinuria, were noted.
  
  
  RESULTS
  Mean SFCT of groups 1, 2, and 3 were 333.8 ± 55.3 μm (range 235-440 μm), 368.6 ± 67.6 μm (range 223-517 μm), and 334.8 ± 59.9 μm (range 197-432 μm), respectively. The mean SFCT was thicker in group 2 than that in groups 1 and 3 (p = 0.045 and p = 0.038, respectively), whereas no significant difference was seen between groups 1 and 3 (p = 1.0). In group 1, SFCT showed a negative correlation with the CCT (p = 0.009, r = -0.493). In group 2, SFCT showed a positive correlation with OPP (p = 0.030, r = 0.321) and a negative correlation with gestational age and fetal weight (p = 0.008, r = -0.387 and p = 0.011, r = -0.373, respectively).
  
  
  CONCLUSIONS
  Our results suggested that SFCT was significantly thicker in normal pregnant women than non-pregnant women. However, SFCT values of preeclamptic women were similar to those of non-pregnant women.
authors.affiliation: Department of Ophthalmology, Kanuni Sultan Suleyman Education and Research Hospital , Istanbul , Turkey .
authors.forename: Nihat
authors.initials: N
authors.lastname: Sayin
authors.forename: Necip
authors.initials: N
authors.lastname: Kara
authors.forename: Dilara
authors.initials: D
authors.lastname: Pirhan
authors.forename: Asli
authors.initials: A
authors.lastname: Vural
authors.forename: Hatice Bilge
authors.initials: HB
authors.lastname: Araz Ersan
authors.forename: Ali Ismet
authors.initials: AI
authors.lastname: Tekirdag
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Polat
authors.forename: Bekir
authors.initials: B
authors.lastname: Gulac
authors.forename: Gokce
authors.initials: G
authors.lastname: Yilmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D058452:Axial Length, Eye; D001794:Blood Pressure; D002829:Choroid / Q000033:anatomy & histology / Q000473:pathology*; D003315:Cornea / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D005584:Fovea Centralis; D005865:Gestational Age; D064368:Healthy Volunteers; D006801:Humans; D007429:Intraocular Pressure; D008875:Middle Aged; D009929:Organ Size; D011225:Pre-Eclampsia / Q000209:etiology / Q000503:physiopathology*; D011247:Pregnancy; D011446:Prospective Studies; D012030:Refractive Errors / Q000175:diagnosis; D041623:Tomography, Optical Coherence; D055815:Young Adult