title: The use of dermal substitutes in burn surgery: acute phase.
abstract: Major burns represent a challenge in autologous skin coverage and may lead to severe functional and cosmetic sequelae. Dermal substitutes are increasingly becoming an essential part of burn care during the acute phase of treatment. In the long term dermal substitutes improve functional and cosmetic results and thus enhance quality of life. In the chronic wound setting, dermal substitutes are used to reconstruct and improve burn scars and defects. Despite the potential of dermal substitutes, further research is required to strengthen scientific evidence regarding their effects and also to develop new technologies and products. Furthermore, dermal substitutes have a pivotal role in future research strategies as they have the potential to provide adequate scaffold for stem cells, tissue engineering, and regenerative medicine with conceivable application of obtaining long-lasting and scarless artificial skin. This review discusses the status quo of dermal substitutes and novel strategies in the use of dermal substitutes with a focus on burn care.
authors.affiliation: Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Shahriar
authors.initials: S
authors.lastname: Shahrokhi
authors.forename: Anna
authors.initials: A
authors.lastname: Arno
authors.forename: Marc G
authors.initials: MG
authors.lastname: Jeschke
mesh_terms: D002056:Burns / Q000473:pathology / Q000628:therapy*; D018929:Cell Culture Techniques / Q000379:methods / Q000639:trends*; D002921:Cicatrix / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D019651:Plastic Surgery Procedures / Q000379:methods* / Q000639:trends; D012867:Skin / Q000033:anatomy & histology / Q000473:pathology*; D016038:Skin Transplantation / Q000379:methods / Q000639:trends; D017768:Skin, Artificial / Q000706:statistics & numerical data* / Q000639:trends; D023822:Tissue Engineering / Q000379:methods / Q000639:trends; D014945:Wound Healing