title: The relationship between health-related quality of life, obesity and testosterone levels in older men.
abstract: BACKGROUND
  quality of life evaluated by Short-Form 36 (SF-36) is decreased in obesity and hypogonadism, but the importance of regional fat mass is unknown. In the present study, we evaluated associations between SF-36, regional fat deposits and bioavailable testosterone (BioT) in ageing men.
  
  
  METHODS
  a population-based cross-sectional study in older men. Data included SF-36 questionnaires with the dimensions such as physical function, role limitations physical, bodily pain, general health, vitality, social function, role limitations emotional and mental health. Furthermore, waist, lean body mass (measured by dual X-ray absorptiometry), visceral adipose tissue and subcutaneous adipose tissue (SAT) (measured by magnetic resonance imaging) and BioT were established.
  
  
  RESULTS
  five hundred and ninety-eight men aged 60-74 years were included. The SF-36 dimensions such as physical function, general health, vitality and role limitations functional were inversely associated with waist and SAT and positively associated with BioT. In multiple regression analysis, waist was the body composition measure with the strongest association with SF-36 dimension scores.
  
  
  CONCLUSIONS
  SF-36 dimension scores were more closely associated with central obesity than with BioT.
  
  
  BACKGROUND
  www.clinicaltrials.gov, NCT00155961.
authors.affiliation: Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5th Floor, Odense C, Denmark.
authors.forename: Dorte
authors.initials: D
authors.lastname: Glintborg
authors.forename: Torben Leo
authors.initials: TL
authors.lastname: Nielsen
authors.forename: Kristian
authors.initials: K
authors.lastname: Wraae
authors.forename: David
authors.initials: D
authors.lastname: Hougaard
authors.forename: Claire
authors.initials: C
authors.lastname: Gudex
authors.forename: Kim
authors.initials: K
authors.lastname: Brixen
authors.forename: Marianne
authors.initials: M
authors.lastname: Andersen
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000367:Age Factors; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood* / Q000175:diagnosis; D011788:Quality of Life; D012737:Sex Factors; D050151:Subcutaneous Fat / Q000378:metabolism / Q000473:pathology; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood*; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D013739:Testosterone
keywords: DXA; MRI; SF-36; body composition; men; older people; population-based; quality of life; testosterone