title: Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1.
abstract: MicroRNAs mainly inhibit coding genes and long non-coding RNA expression. Here, we report that hsa-miR-125b and oncogene SIRT7/oncogenic long non-coding RNA MALAT1 were inversely expressed in bladder cancer. Hsa-miR-125b mimic down-regulated, whereas hsa-miR-125b inhibitor up-regulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsa-miR-125b and SIRT7/MALAT1. Up-regulation of hsa-miR-125b or down-regulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of up-regulation of hsa-miR-125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Han
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Liu
authors.forename: Hu
authors.initials: H
authors.lastname: Zhang
authors.forename: Tiantian
authors.initials: T
authors.lastname: Wang
authors.forename: Ruiying
authors.initials: R
authors.lastname: Diao
authors.forename: Zhimao
authors.initials: Z
authors.lastname: Jiang
authors.forename: Yaoting
authors.initials: Y
authors.lastname: Gui
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Cai
mesh_terms: D017209:Apoptosis; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D057809:HEK293 Cells; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D062085:RNA, Long Noncoding / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*; D014158:Transcription, Genetic; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology
chemical_list: C557041:MALAT1 long non-coding RNA, human; C531888:MIRN125 microRNA, human; D035683:MicroRNAs; D062085:RNA, Long Noncoding; C510661:SIRT7 protein, human; D037761:Sirtuins