title: Tissue penetration of antifungal agents.
abstract: Understanding the tissue penetration of systemically administered antifungal agents is critical for a proper appreciation of their antifungal efficacy in animals and humans. Both the time course of an antifungal drug and its absolute concentrations within tissues may differ significantly from those observed in the bloodstream. In addition, tissue concentrations must also be interpreted within the context of the pathogenesis of the various invasive fungal infections, which differ significantly. There are major technical obstacles to the estimation of concentrations of antifungal agents in various tissue subcompartments, yet these agents, even those within the same class, may exhibit markedly different tissue distributions. This review explores these issues and provides a summary of tissue concentrations of 11 currently licensed systemic antifungal agents. It also explores the therapeutic implications of their distribution at various sites of infection.
authors.affiliation: The University of Manchester, Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom.
authors.forename: Timothy
authors.initials: T
authors.lastname: Felton
authors.forename: Peter F
authors.initials: PF
authors.lastname: Troke
authors.forename: William W
authors.initials: WW
authors.lastname: Hope
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D009181:Mycoses / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents