title: Nizatidine ameliorates gastroparesis in Parkinson's disease: a pilot study.
abstract: BACKGROUND
  The objective of this work was to perform an open trial of the effects of nizatidine (NZT), a selective histamine H2-receptor antagonist and a cholinomimetic, on gastroparesis in Parkinson's disease (PD) patients, using objective parameters given by a gastric emptying study using a (13) C-sodium acetate expiration breath test.
  
  
  METHODS
  Twenty patients with PD were enrolled in the study. There were 13 men and 7 women; aged 68.0 ± 7.72 years; disease duration 5.50 ± 3.62 years. All patients underwent the breath test and a gastrointestinal questionnaire before and after 3 months of administration of NZT at 300 mg/day. Statistical analysis was performed by Student t test.
  
  
  RESULTS
  NZT was well tolerated by all patients and none had abdominal pain or other adverse effects. NZT significantly shortened Tmax ((13) C) (the peak time of the (13) C-dose-excess curve) (P < 0.05).
  
  
  CONCLUSIONS
  Although this is a pilot study, we found a significant shortening of gastric emptying time after administration of NZT in PD patients.
authors.affiliation: Pharmaceutical Unit, Sakura Medical Center, Toho University, Sakura, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Doi
authors.forename: Ryuji
authors.initials: R
authors.lastname: Sakakibara
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Sato
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Hirai
authors.forename: Tohru
authors.initials: T
authors.lastname: Masaka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kishi
authors.forename: Yohei
authors.initials: Y
authors.lastname: Tsuyusaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tateno
authors.forename: Fuyuki
authors.initials: F
authors.lastname: Tateno
authors.forename: Osamu
authors.initials: O
authors.lastname: Takahashi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ogata
mesh_terms: D000368:Aged; D005260:Female; D018589:Gastroparesis / Q000188:drug therapy* / Q000209:etiology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016567:Nizatidine / Q000627:therapeutic use*; D010300:Parkinson Disease / Q000150:complications*; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D006635:Histamine H2 Antagonists; D016567:Nizatidine
keywords: Parkinson's disease; gastric emptying; gastroparesis; levodopa; nizatidine