title: Draft genomes of three Antarctic Psychrobacter strains producing antimicrobial compounds against Burkholderia cepacia complex, opportunistic human pathogens.
abstract: Herein we present the draft genomes of three Psychrobacter strains isolated from Antarctic sponges and able to inhibit the growth of bacteria belonging to the Burkholderia cepacia complex, responsible for infections of the respiratory system in patients affected by Cystic Fibrosis. The comparative analysis of the annotated genomes of these Psychrobacter strains highlighted their differences in terms of overall genomic content (e.g. shared gene sets) and allowed the identification of gene clusters hypothetically involved in the biosynthesis of antimicrobial compounds.
authors.affiliation: Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy; Computer Laboratory, Cambridge University, William Gates Building 15, JJ Thomson Avenue, Cambridge, United Kingdom. Electronic address: marco.fondi@unifi.it.
authors.forename: Marco
authors.initials: M
authors.lastname: Fondi
authors.affiliation: Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy; Institute of Protein Biochemistry, National Research Council, Via P. Castellino, 111 I-80134 Naples, Italy.
authors.forename: Valerio
authors.initials: V
authors.lastname: Orlandini
authors.affiliation: Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Perrin
authors.affiliation: Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy.
authors.forename: Isabel
authors.initials: I
authors.lastname: Maida
authors.affiliation: Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy.
authors.forename: Emanuele
authors.initials: E
authors.lastname: Bosi
authors.affiliation: Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy.
authors.forename: Maria Cristiana
authors.initials: MC
authors.lastname: Papaleo
authors.affiliation: Department of Biological and Environmental Sciences (DiSBA-CIBAN), University of Messina, Viale Ferdinando Stagno d'Alcontrès 31, I-98166 Messina, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Michaud
authors.affiliation: Department of Biological and Environmental Sciences (DiSBA-CIBAN), University of Messina, Viale Ferdinando Stagno d'Alcontrès 31, I-98166 Messina, Italy.
authors.forename: Angelina
authors.initials: A
authors.lastname: Lo Giudice
authors.affiliation: Institute of Protein Biochemistry, National Research Council, Via P. Castellino, 111 I-80134 Naples, Italy.
authors.forename: Donatella
authors.initials: D
authors.lastname: de Pascale
authors.affiliation: Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario M. S. Angelo, Via Cintia, I-80126 Naples, Italy.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Tutino
authors.affiliation: Computer Laboratory, Cambridge University, William Gates Building 15, JJ Thomson Avenue, Cambridge, United Kingdom.
authors.forename: Pietro
authors.initials: P
authors.lastname: Liò
authors.affiliation: Laboratory of Microbial and Molecular Evolution, Department of Biology, University of Florence, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Firenze, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Fani
mesh_terms: D000818:Animals; D000864:Antarctic Regions; D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D001483:Base Sequence; D042602:Burkholderia cepacia complex / Q000187:drug effects*; D020451:Contig Mapping; D016680:Genome, Bacterial / Q000235:genetics*; D023281:Genomics; D058977:Molecular Sequence Annotation; D008969:Molecular Sequence Data; D010802:Phylogeny; D011161:Porifera / Q000382:microbiology*; D044096:Psychrobacter / Q000737:chemistry* / Q000145:classification / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013045:Species Specificity
chemical_list: D000900:Anti-Bacterial Agents
keywords: Antarctic bacteria; Burkholderia infections; Comparative genomics; Genomics