title: [Significance of microRNA expression in body fluids in the diagnosis of gastrointestinal tumors].
abstract: MicroRNAs are small, non-coding, single strained RNAs that regulate gene expression at the posttranscriptional level. They are involved in all major aspects of cellular functions, such as cell cycle, differentiation, migration, apoptosis etc. The role of microRNAs as potential biomarkers of several malignant diseases is being intensively investigated, since they can be found in the body fluids, too, besides their usual intracellular localisation. MicroRNAs have been detected in blood, saliva, stool, breast milk, urine, bile etc. In this review the authors discuss recent findings in the field of microRNAs in stool, bile and saliva, underlying their potential significance in the diagnosis of gastrointestinal tumors.
authors.affiliation: Szent Imre Egyetemi Oktatókórház Gasztroenterológia Profil Budapest Tétényi út 12-16. 1115.
authors.forename: Iván
authors.initials: I
authors.lastname: Igaz
authors.affiliation: Szent Imre Egyetemi Oktatókórház Gasztroenterológia Profil Budapest Tétényi út 12-16. 1115.
authors.forename: Lajos
authors.initials: L
authors.lastname: Topa
mesh_terms: D001646:Bile / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005243:Feces / Q000737:chemistry*; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D012463:Saliva / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs
keywords: biomarker; body fluid; gastrointestinal tumours; gyomor-bél rendszeri daganatok; microRNA; mikro-RNS; testfolyadék