title: Benzofuran derivatives from alkynyl-substituted benzynes and aryl halides.
abstract: A palladium(0)-catalyzed cascade reaction for the efficient synthesis of 2,3-disubstituted benzofuran derivatives 3 containing a 3-trisubstituted alkene functional group in moderate yields from alkynyl-substituted benzynes 1 and aryl halides 2 has been developed. This method provides an efficient and alternative approach to benzofurans which are very useful heterocyclic compounds with biological and pharmacological potentials. A plausible mechanism involving intramolecular ene reaction, intermolecular insertion, and β-H elimination is proposed.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University , 3663 North Zhongshan Lu, Shanghai 200062, P. R. China.
authors.forename: Weiming
authors.initials: W
authors.lastname: Yuan
authors.forename: Shengming
authors.initials: S
authors.lastname: Ma
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
chemical_list: D000480:Alkynes; D001555:Benzene Derivatives; D001572:Benzofurans; D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; D010165:Palladium; C105430:benzofuran