title: [Relationship between body fat distribution and insulin resistance, islet β cell function and metabolic disorders in adults].
abstract: OBJECTIVE
  To explore the relationship between body fat distribution, insulin resistance, islet β cell function and metabolic disorders in adult population.
  
  
  METHODS
  From February to November 2012, a total of 174 subjects aged 20-68 years were recruited. Their anthropometric parameters, blood biochemical indices and the results of oral glucose tolerance test (OGTT) and insulin releasing test (IRT) were collected. Body fat distribution was measured with dual energy X-ray absorptiometry (DEXA).
  
  
  RESULTS
  The values of trunk/total fat mass (T/B) and android/gynoid fat mass ratio (A/G) were positively correlated with blood pressure, blood lipid, plasma glucose, insulin resistance index (HOMA-IR) and high-sensitivity C-reactive protein. Compared with the group of normal metabolism, the group of metabolic disorders had higher T/B and A/G (P < 0.05). After multiple stepwise regression analysis, the main influencing factors of lnHOMA-IR and lnHOMA-β were T/B and Grespectively.Logistic regression showed that A (OR = 3.01, 95%CI 1.86-8.17) was a risk factor for diabetes and A/G (OR = 2.71, 95%CI 1.75-6.56) a risk factor for dyslipidemia.
  
  
  CONCLUSIONS
  Trunk and android fat deposition aggravates insulin resistance, metabolic disorders. And the main influencing factors of insulin resistance and islet β cell function are trunk and gynoid fat respectively. Android fat mass is a major risk factor for glycolipid metabolism.
authors.affiliation: Diabetes Center, Department of Endocrinology, Institute of Metabolism & Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Xiao-jie
authors.initials: XJ
authors.lastname: Yang
authors.affiliation: Diabetes Center, Department of Endocrinology, Institute of Metabolism & Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Yao
authors.affiliation: Diabetes Center, Department of Endocrinology, Institute of Metabolism & Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Kuan
authors.initials: K
authors.lastname: Yan
authors.affiliation: Diabetes Center, Department of Endocrinology, Institute of Metabolism & Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Gan
authors.initials: G
authors.lastname: Huang
authors.affiliation: Diabetes Center, Department of Endocrinology, Institute of Metabolism & Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Zhi-guang
authors.initials: ZG
authors.lastname: Zhou
authors.affiliation: Diabetes Center, Department of Endocrinology, Institute of Metabolism & Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Miao-jiao
authors.initials: MJ
authors.lastname: Chen
authors.affiliation: Diabetes Center, Department of Endocrinology, Institute of Metabolism & Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Xian-ping
authors.initials: XP
authors.lastname: Wu
authors.affiliation: Diabetes Center, Department of Endocrinology, Institute of Metabolism & Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China. Email: shipingliu119@126.com.
authors.forename: Shi-ping
authors.initials: SP
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D050218:Body Fat Distribution; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D008659:Metabolic Diseases / Q000378:metabolism* / Q000503:physiopathology; D008875:Middle Aged; D055815:Young Adult