title: Differential expression of monocyte surface markers among TB patients with diabetes co-morbidity.
abstract: The expression of monocyte surface markers was compared between tuberculosis patients with and without type 2 diabetes (DM2). DM2 was associated with increased CCR2 expression, which may restrain monocyte traffic to the lung. Other host factors associated with baseline monocyte changes were older age (associated with lower CD11b) and obesity (associated with higher RAGE). Given that DM2 patients are more likely to be older and obese, their monocytes are predicted to be altered in function in ways that affect their interaction with Mycobacterium tuberculosis.
authors.affiliation: UT Health Houston, School of Public Health at Brownsville, 80 Fort Brown, Brownsville, Texas 78520, USA; The Advisory Board Company, Austin, Texas, USA.
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Stew
authors.affiliation: UT Health Houston, School of Public Health at Brownsville, 80 Fort Brown, Brownsville, Texas 78520, USA.
authors.forename: Perla J
authors.initials: PJ
authors.lastname: Martinez
authors.affiliation: Center for Microbial Interface Biology and Department of Microbial Infection and Immunity, 460W 12th Ave, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Larry S
authors.initials: LS
authors.lastname: Schlesinger
authors.affiliation: Center for Microbial Interface Biology and Department of Microbial Infection and Immunity, 460W 12th Ave, The Ohio State University, Columbus, Ohio 43210, USA. Electronic address: blanca.i.restrepo@uth.tmc.edu.
authors.forename: Blanca I
authors.initials: BI
authors.lastname: Restrepo
mesh_terms: D000375:Aging / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D015992:Body Mass Index; D039481:CD11b Antigen / Q000378:metabolism; D002448:Cell Adhesion; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000378:metabolism*; D004198:Disease Susceptibility; D005260:Female; D054884:Host-Pathogen Interactions; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000502:physiology*; D011379:Prognosis; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism; D054390:Receptors, CCR2 / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014376:Tuberculosis / Q000276:immunology / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C515334:CCR2 protein, human; D039481:CD11b Antigen; C509295:ITGAM protein, human; D000067759:Receptor for Advanced Glycation End Products; D054390:Receptors, CCR2; D011956:Receptors, Cell Surface
keywords: CCR2; CD11b; Diabetes; Innate immunity; Monocyte; RAGE; Tuberculosis