title: Common variants of apolipoprotein E and cholesteryl ester transport protein genes in male patients with coronary heart disease and variable body mass index.
abstract: Plasma lipids are major risk factors for coronary heart disease (CHD). Cholesteryl ester transfer protein (CETP) and apolipoprotein (apo) E genes are involved in lipoprotein metabolism, thus affecting plasma lipid and lipoproteins levels. Furthermore, such polymorphisms have been associated with susceptibility to CHD and obesity. We evaluated the influence of the gene polymorphisms of CETP TaqIB (B1, B2) and I405V (V, I) and apo E (∊2,∊3,∊4) on lipid levels, according to body mass index (BMI) in Greek men with CHD. The TaqIB (B1, B2) polymorphism affected plasma low-density lipoprotein cholesterol levels in overweight men with CHD, whereas the I405V (V, I) polymorphism affected triglyceride concentrations in normal weight men. No correlation was found between BMI and apo E polymorphisms. Large prospective studies are required to investigate the relationships of CETP and apo E polymorphisms with lipids, BMI, and CHD susceptibility.
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece genovefa@kolovou.com.
authors.forename: Genovefa D
authors.initials: GD
authors.lastname: Kolovou
authors.affiliation: Department of Nutrition and Dietetic, Harokopio University, Athens, Greece.
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Vana
authors.initials: V
authors.lastname: Kolovou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece Department of Clinical Biochemistry (Vascular Disease Prevention Clinics), Royal Free Hospital campus, University College London Medical School, University College London (UCL), London, United Kingdom.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vasiliadis
authors.affiliation: Thriasio Hospital, Elevsina, Greece.
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Giannakopoulou
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Olga
authors.initials: O
authors.lastname: Diakoumakou
authors.affiliation: Second Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippocration Hospital, Thessaloniki, Greece.
authors.forename: Niki
authors.initials: N
authors.lastname: Katsiki
authors.affiliation: Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.
authors.forename: Sophie
authors.initials: S
authors.lastname: Mavrogeni
mesh_terms: D000368:Aged; D053329:Apolipoprotein E2 / Q000235:genetics; D053318:Apolipoprotein E3 / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006115:Greece; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D015415:Biomarkers; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: apolipoprotein E; body mass index; cholesteryl ester transfer protein; gene polymorphisms; lipids; obesity