title: Quality of life in patients with primary hyperparathyroidism.
abstract: The clinical picture of primary hyperparathyroidism (PHPT) has changed over the last three decades and many asymptomatic patients are now diagnosed through the unexpected finding of high serum calcium levels. However, though not yet considered as typical features of the disease and therefore not included in the guidelines for surgery, many data are available on neuropsycological manifestations and their impact on quality of life in asymptomatic patients. PHPT patients indeed show early experience nonspecific symptoms, such as weakness, depression, sleep disturbance, memory loss and anxiety. Although the underlining mechanisms have not been still identified, the prevalence of psychiatric and cognitive deficits has been investigated in many studies, as well as the possible association with quality of life and well-being improvement after surgery. This article aims to review the current knowledge on quality of life in PHPT patients before and after surgery and the possible clinical implications of these findings.
authors.affiliation: Department of Internal Medicine and Medical Disciplines, "Sapienza" University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Cipriani
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Romagnoli
authors.forename: Mirella
authors.initials: M
authors.lastname: Cilli
authors.forename: Sara
authors.initials: S
authors.lastname: Piemonte
authors.forename: Jessica
authors.initials: J
authors.lastname: Pepe
authors.forename: Salvatore
authors.initials: S
authors.lastname: Minisola
mesh_terms: D002118:Calcium / Q000097:blood; D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D016105:Parathyroidectomy / Q000379:methods*; D017410:Practice Guidelines as Topic; D015995:Prevalence; D011788:Quality of Life; D016896:Treatment Outcome
chemical_list: D002118:Calcium