title: Exploring the role of short-course cyclosporin a therapy in preventing homograft valve calcification after transplantation.
abstract: This study was designed to explore the role of short-course cyclosporin A therapy in preventing calcification. Homograft valves heterotopically allografted onto abdominal aorta from SD to Wistar rats. The expression of CD25, CD40L, CD71, calcium content and morphological change were observed. In control group, expression of immune indices got maximal at early stage postoperatively, and then gradually declined, remained at low level 12 weeks afterwards. In test group with Cyclosporin A, the expression of immune indices were lower than that of control group at 2-4 weeks postoperatively, but no significant difference was found 8 weeks afterwards. The calcification began from 4 weeks postoperatively, increased gradually and reached highest level at 12 weeks. In test group calcium content was much lower from 4 to 16 weeks postoperatively. It is concluded that cyclosporine A treatment can prevent calcification of homograft valves because it inhibited immune response at early stage after transplantation.
authors.affiliation: Cardiovascular Surgery Department, The Affiliated Hospital of Medical College, Qingdao University, 266003 Qingdao, China. Electronic address: changqing20671@163.com.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chang
authors.affiliation: Cardiovascular Surgery Department, The Affiliated Hospital of Medical College, Qingdao University, 266003 Qingdao, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Jing
authors.affiliation: Rheumatology Department, The Affiliated Hospital of Medical College, Qingdao University, 266003 Qingdao, China.
authors.forename: Mingshu
authors.initials: M
authors.lastname: Sun
authors.affiliation: Cardiovascular Surgery Department, The Affiliated Hospital of Medical College, Qingdao University, 266003 Qingdao, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Xu
mesh_terms: D064591:Allografts / Q000276:immunology / Q000378:metabolism* / Q000637:transplantation; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001021:Aortic Valve / Q000276:immunology / Q000378:metabolism* / Q000637:transplantation; D002118:Calcium / Q000378:metabolism; D016572:Cyclosporine / Q000008:administration & dosage*; D005260:Female; D008297:Male; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D014181:Transplantation Immunology; D061205:Vascular Calcification / Q000209:etiology / Q000517:prevention & control*
chemical_list: D015703:Antigens, CD; D016572:Cyclosporine; D002118:Calcium
keywords: Calcification; Cyclosporine A; Degeneration; Homograft valve; Immunology; Rat; Transplantation