title: SCUBE3 overexpression predicts poor prognosis in non-small cell lung cancer.
abstract: Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is highly expressed in invasive lung cancers. In vitro investigation indicated that SCUBE3 may play a critical role in lung cancer invasion and metastasis. The current study immunohistochemically investigated the expression of SCUBE3 in 119 cases of non-small cell lung cancer (NSCLC) tumors and this study evaluated its clinical-pathological and prognostic significance. SCUBE3 was found to be up-regulated in NSCLC tissue samples compared to adjacent normal tissue. High SCUBE3 expression was noted in 84/119 (70.6%) of NSCLC tissue samples and was positively correlated with lymph node involvement (p = 0.001) and advanced stages of tumor/lymph node metastasis (TNM) (p = 0.014). Furthermore, high SCUBE3 expression was significantly associated with loss of the epithelial marker E-cadherin (p = 0.0015) and acquisition of expression of the mesenchymal marker vimentin (p = 0.005). Patients with high SCUBE3 expression had significantly a shorter survival time compared to patients with low SCUBE3 expression (p = 0.001), and SCUBE3 expression served as an independent prognostic factor for NSCLC patients. Results indicated that SCUBE3 might be involved in regulating the epithelial-mesenchymal transition (EMT) and malignant progression in NSCLC. Results also indicated that SCUBE3d may be a potential therapeutic target for lung cancers.
authors.affiliation: Department of Laboratory Diagnostic, Changhai Hospital, Second Military Medical University, Shanghai, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhao
authors.forename: Qin
authors.initials: Q
authors.lastname: qin
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Wang
authors.forename: Jianrong
authors.initials: J
authors.lastname: Zhang
authors.forename: Yulian
authors.initials: Y
authors.lastname: Xu
authors.forename: Wenjie
authors.initials: W
authors.lastname: Li
authors.forename: Mingli
authors.initials: M
authors.lastname: Gu
authors.forename: Sunxiao
authors.initials: S
authors.lastname: Chen
authors.forename: Anmei
authors.initials: A
authors.lastname: Deng
mesh_terms: D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged
chemical_list: D002135:Calcium-Binding Proteins; C493800:SCUBE3 protein, human