title: Oxoglaucine-lanthanide complexes: synthesis, crystal structure and cytotoxicity.
abstract: OBJECTIVE
  To evaluate the in vitro cytotoxicity of oxoglaucine (OG) complexes: [Sm(OG)2(NO3)3]•H2O (1), [Eu(OG)2(NO3)3]•1.5CH3OH (2) and [Er(OG)2(NO3)3]•H2O (3) through comparison to oxoglaucine and lanthanide salts.
  
  
  METHODS
  The reactions of OG with corresponding lanthanide salts gave rise to complexes 1-3. The crystal structures of complexes 1-3 were determined by single-crystal X-ray diffraction analysis. The in vitro cytotoxicity of oxoglaucine and complexes 1-3 against five human cancer cell lines were evaluated by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium Bromide (MTT) method.
  
  
  RESULTS
  Complexes 1-3 have similar mononuclear structures. The 50% inhibitory concentration (IC50) of complex 1 against SGC7901 cells was 32.1 μM; that of complex 2 against MCF-7 cells was 3.2 μM; those of complex 3 on HeLa and MCF-7 cells were 8.3 and 1.4 μM, respectively.
  
  
  CONCLUSIONS
  The three OG-lanthanide complexes exhibited significantly enhanced cytotoxicity vs. OG and corresponding lanthanide salts.
authors.affiliation: Guangxi Normal University, No. 15, Yucai Road, Guilin, China. Tel/Fax: +86 7732120958, chenzfubc@yahoo.com.
authors.forename: Yan-Cheng
authors.initials: YC
authors.lastname: Liu
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Chen
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Shi
authors.forename: Ke-Bin
authors.initials: KB
authors.lastname: Huang
authors.forename: Bo
authors.initials: B
authors.lastname: Geng
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
mesh_terms: D001058:Apomorphine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D018360:Crystallography, X-Ray; D006801:Humans; D020128:Inhibitory Concentration 50; D028581:Lanthanoid Series Elements / Q000737:chemistry* / Q000494:pharmacology*; D008958:Models, Molecular; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014407:Tumor Cells, Cultured
chemical_list: D028581:Lanthanoid Series Elements; C111587:oxoglaucine; D001058:Apomorphine
keywords: Lanthanide complex; crystal structure; cytotoxicity; oxoglaucine