title: (±)-Aspongamide A, an N-acetyldopamine trimer isolated from the insect Aspongopus chinensis, is an inhibitor of p-Smad3.
abstract: (±)-Aspongamide A (1), an unusual trimer of N-acetyldopamine (NADA) bearing a novel tetrahydrobenzo[a]dibenzo[b,e][1,4]dioxine structure, and a pair of NADA dimeric enantiomers (2) were isolated from Aspongopus chinensis. The structures of compounds 1 and 2 were assigned using spectroscopic methods. Compound 1 was found to be an inhibitor of Smad3 phosphorylation in transforming growth factor-β1 (TGF-β1) induced rat renal proximal tubular cells and suppressed extracellular matrix expression in mesangial cells under diabetic conditions.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , 132 Lanhei Road, Kunming 650201, P. R. China.
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yan
authors.forename: Jun
authors.initials: J
authors.lastname: Ai
authors.forename: Yan-Ni
authors.initials: YN
authors.lastname: Shi
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Zuo
authors.forename: Bo
authors.initials: B
authors.lastname: Hou
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Yong-Xian
authors.initials: YX
authors.lastname: Cheng
mesh_terms: D000818:Animals; D004298:Dopamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006430:Hemiptera / Q000737:chemistry*; D050527:Mesangial Cells / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010766:Phosphorylation; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction; D051900:Smad3 Protein / Q000037:antagonists & inhibitors*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D051900:Smad3 Protein; D053773:Transforming Growth Factor beta1; C000589997:aspongamide A; C006374:N-acetyldopamine; D004298:Dopamine