title: Drug perfusion enhancement in tissue model by steady streaming induced by oscillating microbubbles.
abstract: Drug delivery into neurological tissue is challenging because of the low tissue permeability. Ultrasound incorporating microbubbles has been applied to enhance drug delivery into these tissues, but the effects of a streaming flow by microbubble oscillation on drug perfusion have not been elucidated. In order to clarify the physical effects of steady streaming on drug delivery, an experimental study on dye perfusion into a tissue model was performed using microbubbles excited by acoustic waves. The surface concentration and penetration length of the drug were increased by 12% and 13%, respectively, with streaming flow. The mass of dye perfused into a tissue phantom for 30s was increased by about 20% in the phantom with oscillating bubbles. A computational model that considers fluid structure interaction for streaming flow fields induced by oscillating bubbles was developed, and mass transfer of the drug into the porous tissue model was analyzed. The computed flow fields agreed with the theoretical solutions, and the dye concentration distribution in the tissue agreed well with the experimental data. The computational results showed that steady streaming with a streaming velocity of a few millimeters per second promotes mass transfer into a tissue.
authors.affiliation: Department of Mechanical Engineering, Myongji University, 38-2, Nam-dong, Yongin, Kyunggi-do 449-728, South Korea.
authors.forename: Jin Sun
authors.initials: JS
authors.lastname: Oh
authors.affiliation: Department of Mechanical Engineering, Myongji University, 38-2, Nam-dong, Yongin, Kyunggi-do 449-728, South Korea.
authors.forename: Yong Seok
authors.initials: YS
authors.lastname: Kwon
authors.affiliation: Department of Mechanical Engineering, Myongji University, 38-2, Nam-dong, Yongin, Kyunggi-do 449-728, South Korea.
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Lee
authors.affiliation: Department of Mechanical Engineering, Myongji University, 38-2, Nam-dong, Yongin, Kyunggi-do 449-728, South Korea.
authors.forename: Woowon
authors.initials: W
authors.lastname: Jeong
authors.affiliation: Department of Mechanical Engineering, Myongji University, 38-2, Nam-dong, Yongin, Kyunggi-do 449-728, South Korea.
authors.forename: Sang Kug
authors.initials: SK
authors.lastname: Chung
authors.affiliation: Department of Mechanical Engineering, Myongji University, 38-2, Nam-dong, Yongin, Kyunggi-do 449-728, South Korea. Electronic address: khanrhee@mju.ac.kr.
authors.forename: Kyehan
authors.initials: K
authors.lastname: Rhee
mesh_terms: D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D045423:Microbubbles; D008962:Models, Theoretical; D009417:Nerve Tissue; D010539:Permeability; D014465:Ultrasonics
keywords: Acoustic wave; Computational fluid mechanics; Drug delivery; Microbubble; Steady streaming