title: Glutathione S-transferase A1 polymorphism and the risk of recurrent spontaneous abortion in Chinese Han population.
abstract: OBJECTIVE
  Recurrent spontaneous abortion (RSA) is a multifactor and distressing disease. There are still approximately half of the RSA patients with cause not being identified to date. Accumulating studies have confirmed that genetic polymorphisms in glutathione S-transferases (GSTs) were associated with the risk of recurrent spontaneous abortion. In this study, we aimed to investigate the relationship between the polymorphism of GSTA1, which is GSTA1 -69C/T (rs3957357), and the development of recurrent spontaneous abortion.
  
  
  METHODS
  A case-control study of 127 cases with RSA and 112 ethnic and age matched women as controls was conducted. And measurement of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) was performed to genotype all of samples in order to analyze the association between GSTA1 -69C/T (rs3957357) and the risk of RSA.
  
  
  RESULTS
  We found that the frequencies of genotypes between cases and controls have no significant difference (P = 0.908) and GSTA1 mutant allele GSTA1 -69 T was present at a frequency of 0.122 in case group, while in controls the frequency was 0.125 (P = 0.922).
  
  
  CONCLUSIONS
  The polymorphism of GSTA1 (rs3957357) may not be associated with the risk of recurrent spontaneous abortion in Chinese Han population.
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital, Anhui Medical University, 218 Jixi Road, Hefei, Anhui, 230022, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zong
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Sha
authors.forename: Huifen
authors.initials: H
authors.lastname: Xiang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Dawei
authors.initials: D
authors.lastname: Chen
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics* / Q000473:pathology; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D055815:Young Adult
chemical_list: C484555:GSTA1 protein, human; D005982:Glutathione Transferase