title: A Randomized controlled trial on safety and efficacy of single intramuscular versus staggered oral dose of 600 000IU Vitamin D in treatment of nutritional rickets.
abstract: OBJECTIVE
  Comparison of efficacy and safety of two different regimens of vitamin D-600 000 IU as a single intramuscular dose, and 60 000IU orally once a week for 10 weeks-in treatment of nutritional rickets.
  
  
  METHODS
  Children with nutritional rickets (age: 0.5-5 years, n = 61) were randomized to receive either 60 000IU vitamin D orally once a week for 10 weeks or 600 000IU single intramuscular injection. Serum calcium, phosphate, alkaline phosphatase, urinary calcium/creatinine ratio, serum 25 hydroxy vitamin D and radiological score were compared at 12-week follow-up.
  
  
  RESULTS
  No difference was found in efficacy of the two regimens on comparing biochemical and radiological parameters. Serum 25 hydroxy vitamin D >100 ng/ml was found in two children in the oral group and one child in the intramuscular group. No child developed hypercalcemia or hypercalciuria after starting treatment.
  
  
  CONCLUSIONS
  Staggered oral and one-time intramuscular administrations of 600 000IU vitamin D are equally effective and safe in treatment of nutritional rickets.
authors.affiliation: Department of Paediatrics, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, DL 110001, India.
authors.forename: Krishanu
authors.initials: K
authors.lastname: Mondal
authors.affiliation: Department of Paediatrics, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, DL 110001, India anjuseth.peds@gmail.com.
authors.forename: Anju
authors.initials: A
authors.lastname: Seth
authors.affiliation: Department of Endocrinology, Institute of Nuclear Medicine and Allied Sciences, New Delhi, DL 110001, India.
authors.forename: Raman K
authors.initials: RK
authors.lastname: Marwaha
authors.affiliation: Department of Medicine, Maulana Azad Medical College, New Delhi, DL 110001, India.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Dhanwal
authors.affiliation: Department of Paediatrics, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, DL 110001, India.
authors.forename: Satinder
authors.initials: S
authors.lastname: Aneja
authors.affiliation: Department of Biochemistry, Lady Hardinge Medical College, New Delhi, DL 110001, India.
authors.forename: Ritu
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Radiology, Lady Hardinge Medical College, Kalawati Saran Children's Hospital, New Delhi, DL 110001, India.
authors.forename: Pitambar
authors.initials: P
authors.lastname: Sonkar
mesh_terms: D000284:Administration, Oral; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood; D002648:Child; D002675:Child, Preschool; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D044342:Malnutrition / Q000209:etiology; D012279:Rickets / Q000097:blood / Q000188:drug therapy*; D012959:Socioeconomic Factors; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase; D002118:Calcium
keywords: 25(OH)D; Vitamin D; nutritional rickets; radiological score