title: LncRNAs: new players in gliomas, with special emphasis on the interaction of lncRNAs With EZH2.
abstract: Gliomas are the most common primary malignancy in the brain, accounting for 50-60%. Despite all the efforts of cytoreductive surgery in combination with intense chemoradiotherapy, glioma remains an incurable disease. Recent studies have shown that long noncoding RNAs (lncRNAs) are involved in the pathology of gliomas. LncRNAs are involved in many cellular processes, such as angiogenesis, invasion, cell proliferation, and apoptosis. In this review we focus on the dysregulation of lncRNAs in gliomas. We also address that epigenetic modification such as DNA methylation and microRNAs interact with lncRNAs in gliomas. In addition, the interaction of lncRNAs with signaling pathways in gliomas is discussed systematically, with particular emphasis on the interaction of lncRNAs with EZH2. Such approaches provide valuable insights into the potential future applications of lncRNAs in the treatment of gliomas.
authors.affiliation: Department of Neurosurgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China; Cerebral Vascular Disease Research Center, Anhui Medical University, Hefei, China.
authors.forename: Er-Bao
authors.initials: EB
authors.lastname: Bian
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Xie
authors.forename: Gang
authors.initials: G
authors.lastname: Zong
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
mesh_terms: D017209:Apoptosis / Q000235:genetics; D049109:Cell Proliferation / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics; D000071221:Enhancer of Zeste Homolog 2 Protein; D005910:Glioma / Q000235:genetics* / Q000473:pathology; D006801:Humans; D058990:Molecular Targeted Therapy; D009361:Neoplasm Invasiveness / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics; D063151:Polycomb Repressive Complex 2 / Q000096:biosynthesis / Q000235:genetics*; D062085:RNA, Long Noncoding / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D062085:RNA, Long Noncoding; C498409:EZH2 protein, human; D000071221:Enhancer of Zeste Homolog 2 Protein; D063151:Polycomb Repressive Complex 2