title: Intermolecular (4+3) cycloadditions of aziridinyl enolsilanes.
abstract: Upon activation by strong Brønsted acids, aziridinyl enolsilanes undergo (4+3) cycloadditions with dienes to afford aminoalkylated cycloheptenones as products. The use of a highly polar medium such as nitroalkane facilitates high cycloaddition yields of up to 99%. Optically pure aziridinyl enolsilanes react to yield (4+3) cycloadducts with up to 99% ee.
authors.affiliation: Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The University of Hong Kong, Pokfulam Rd., Hong Kong, PR China. pchiu@hku.hk.
authors.forename: Sze Kui
authors.initials: SK
authors.lastname: Lam
authors.forename: Sarah
authors.initials: S
authors.lastname: Lam
authors.forename: Wing-Tak
authors.initials: WT
authors.lastname: Wong
authors.forename: Pauline
authors.initials: P
authors.lastname: Chiu
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D061565:Cycloaddition Reaction; D012821:Silanes / Q000737:chemistry*
chemical_list: D001388:Aziridines; D012821:Silanes; C033132:aziridine