title: Oral human papillomavirus type-specific infection in HIV-infected men: a prospective cohort study among men who have sex with men and heterosexual men.
abstract: The natural history of type-specific oral infection of human papillomavirus (HPV) was assessed in a cohort of HIV-infected men (538 men who have sex with men (MSM); 195 heterosexuals). Risk factors associated with oral HPV infections were examined. The overall prevalence of HPV was 16%: HPV-16 was the most prevalent type (3.7% MSM; 7.8% heterosexuals). The prevalence of HPV-16 in heterosexuals was associated with CD4 nadir counts <200 cells/μL (ORadjusted = 3.0, 95% CI, 1.4-6.3). The overall incidence of HPV was similar between groups (11%), but the incidence of HPV-16 was higher in heterosexuals (ORadjusted = 3.2, 95% CI, 1.1-9.5). Not only MSM but also HIV-infected heterosexual men are at risk of HPV infection. Regular and careful oral inspection is needed.
authors.affiliation: Lluita Contra La SIDA Foundation, Badalona, Spain; Department of Sanitat i Anatomia Animal, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
authors.forename: L
authors.initials: L
authors.lastname: Darwich
authors.forename: M P
authors.initials: MP
authors.lastname: Cañadas
authors.forename: S
authors.initials: S
authors.lastname: Videla
authors.forename: J
authors.initials: J
authors.lastname: Coll
authors.forename: R A
authors.initials: RA
authors.lastname: Molina-López
authors.forename: P
authors.initials: P
authors.lastname: Cobarsi
authors.forename: G
authors.initials: G
authors.lastname: Sirera
authors.forename: B
authors.initials: B
authors.lastname: Clotet
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D015658:HIV Infections / Q000150:complications*; D020010:Heterosexuality; D018451:Homosexuality, Male; D006801:Humans; D015994:Incidence; D008297:Male; D009059:Mouth Diseases / Q000453:epidemiology* / Q000821:virology; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors
keywords: HIV-infected men; Heterosexuals; MSM; oral HPV types