title: Recent advances in genes involved in secondary metabolite synthesis, hyphal development, energy metabolism and pathogenicity in Fusarium graminearum (teleomorph Gibberella zeae).
abstract: The ascomycete fungus, Fusarium graminearum (teleomorph Gibberella zeae), is the most common causal agent of Fusarium head blight (FHB), a devastating disease for cereal crops worldwide. F. graminearum produces ascospores (sexual spores) and conidia (asexual spores), which can serve as disease inocula of FHB. Meanwhile, Fusarium-infected grains are often contaminated with mycotoxins such as trichothecenes (TRIs), fumonisins, and zearalenones, among which TRIs are related to the pathogenicity of F. graminearum, and these toxins are hazardous to humans and livestock. In recent years, with the complete genome sequencing of F. graminearum, an increasing number of functional genes involved in the production of secondary metabolites, hyphal differentiation, sexual and asexual reproduction, virulence and pathogenicity have been identified from F. graminearum. In this review, the secondary metabolite synthesis, hyphal development and pathogenicity related genes in F. graminearum were thoroughly summarized, and the genes associated with secondary metabolites, sexual reproduction, energy metabolism, and pathogenicity were highlighted.
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming, 650091, PR China.
authors.forename: Zongyi
authors.initials: Z
authors.lastname: Geng
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming, 650091, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming, 650091, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Su
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming, 650091, PR China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming, 650091, PR China. Electronic address: kqzhang1@ynu.edu.cn.
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Zhang
authors.affiliation: Laboratory for Conservation and Utilization of Bio-Resources, and Key Laboratory of Microbial Diversity in Southwest China, Ministry of Education, Yunnan University, Kunming, 650091, PR China. Electronic address: jinkui960@ynu.edu.cn.
authors.forename: Jinkui
authors.initials: J
authors.lastname: Yang
mesh_terms: D005670:Fusarium / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology; D005800:Genes, Fungal / Q000235:genetics*; D005874:Gibberella / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology; D014774:Virulence
keywords: Energy metabolism; Fusarium graminearum; Gibberella zeae; Hyphal development; Pathogenicity; Secondary metabolite; Sexual reproduction