title: Circulating levels of monocyte chemoattractant protein-1 and interleukin-7 in women who have undergone bilateral salpingo-oophorectomy.
abstract: OBJECTIVE
  The aim of the study reported here was to determine the effect of surgical menopause by bilateral salpingo-oophorectomy (BSO) on circulating levels of cytokines and chemokines related to the pathogenesis of atherosclerosis.
  
  
  METHODS
  A total of 110 women were recruited for this study from the outpatient clinic of our facility. We divided the women into three groups: 1) women with a regular menstrual cycle, 2) women in whom less than 5 years had passed since their BSO, and 3) women in whom 5 years or more had passed since their BSO. Concentrations of nine cytokines and chemokines in serum were measured.
  
  
  RESULTS
  The serum monocyte chemoattractant protein-1 (MCP-1) level in women in whom less than 5 years had passed since their BSO was significantly higher than in women with a regular menstrual cycle (P<0.05). There were significant differences in serum interleukin (IL)-7 among the three groups (P=0.035). MCP-1 showed a significant positive correlation (r=0.320, P=0.008) with follicle-stimulating hormone in women with a regular menstrual cycle and in women in whom less than 5 years had passed since their BSO.
  
  
  CONCLUSIONS
  A hypoestrogenic state due to BSO induced changes in MCP-1 and IL-7 levels. MCP-1 level showed a significant increase in the early period after BSO, while IL-7 level showed a significant decrease in the late period after BSO.
authors.affiliation: Department of Obstetrics and Gynecology, Tokushima, Japan.
authors.forename: Anna
authors.initials: A
authors.lastname: Tani
authors.affiliation: Department of Reproductive Technology, Institute of health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yasui
authors.affiliation: Department of Obstetrics and Gynecology, Tokushima, Japan.
authors.forename: Sumika
authors.initials: S
authors.lastname: Matsui
authors.affiliation: Department of Obstetrics and Gynecology, Tokushima, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kato
authors.affiliation: Pharmacology Research Department, Tsumura Central Research Institute, Ibaraki, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Tsuchiya
authors.affiliation: Pharmacology Research Department, Tsumura Central Research Institute, Ibaraki, Japan.
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Yuzurihara
authors.affiliation: Pharmacology Research Department, Tsumura Central Research Institute, Ibaraki, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kase
authors.affiliation: Department of Obstetrics and Gynecology, Tokushima, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
keywords: chemokines; cytokines; follicle-stimulating hormone; hypoestrogenism; surgical menopause