title: Enantioselective 1,4-additions of ClMeAl(CH=CHR) (R = alkyl, alkenyl, Ph) to cyclohexenones.
abstract: Chloromethylvinyl alanes (E)-ClMeAl(CH=CHR) prepared directly from terminal alkynes undergo 1,4-addition to cyclohexenone and 3-methylcyclohexenone in moderate to good yield (30-70%) and good to excellent stereoselectivity (80-98% ee) using readily available copper(I) sources and chiral ligands.
authors.affiliation: School of Chemistry, The University of Nottingham, University Park, Nottingham, UK. simon.woodward@nottingham.ac.uk.
authors.forename: D
authors.initials: D
authors.lastname: Willcox
authors.forename: S
authors.initials: S
authors.lastname: Woodward
authors.forename: A
authors.initials: A
authors.lastname: Alexakis