title: The synergy between lasers and adipose tissues surgery in cervicofacial rejuvenation: histopathological aspects.
abstract: OBJECTIVE
  Nowadays patients want a long-lasting youthful appearance but through a less invasive approach. Our unique approach, "AdipoLASER reJuvenation (ALJ)", involves a variety of less invasive techniques based on simultaneous laser resurfacing, and lipolysis together with adipose tissue graft and redistribution. Recently, we added to this platelet-rich plasma therapy. We conducted a study aiming to emphasize the histopathological changes occurred following these procedures.
  
  
  METHODS
  Between 2011-2012, we included 50 patients that were preparing for abdominoplasty (tummy tuck) in which we applied ALJ procedures, in two comparative zones of inferior abdomen. Histological examination varied from 10 days to four months, according to the time of the abdominoplasty.
  
  
  RESULTS
  There was a notable histological difference between stimulated and non-stimulated fat graft regarding adipose cells structure and number, neocollagenesis, and dermal matrix remodeling.
  
  
  CONCLUSIONS
  The low level laser therapy effect (LLLT) of the fractional CO2 laser combined with the effect of the growth factors derived from activated platelets (PRP) prolonged the life and improved the take of the facial fat graft, increase collagen formation and lead to a better remodeling of the dermal matrix. This unique surgical combination of all four approaches in our ALJ with additional PRP offers a real less invasive but strongly visible - yet natural result - as an alternative to the classic facelift.
authors.affiliation: "Carol Davila" University of Medicine and Pharmacy, Department of Aesthetic Surgery, ProEstetica Medical Center, Bucharest, Romania; djianu02@gmail.com.
authors.forename: Andreea Cristina
authors.initials: AC
authors.lastname: Niţă
authors.forename: Dana Mihaela
authors.initials: DM
authors.lastname: Jianu
authors.forename: I P
authors.initials: IP
authors.lastname: Florescu
authors.forename: Maria
authors.initials: M
authors.lastname: Filipescu
authors.forename: O
authors.initials: O
authors.lastname: Cobani
authors.forename: S A
authors.initials: SA
authors.lastname: Jianu
authors.forename: D A
authors.initials: DA
authors.lastname: Chiriţă
authors.forename: Adriana
authors.initials: A
authors.lastname: Bold
mesh_terms: D017667:Adipocytes / Q000473:pathology; D000273:Adipose Tissue / Q000601:surgery* / Q000637:transplantation; D002584:Cervix Uteri / Q000473:pathology* / Q000601:surgery*; D020405:Dermis / Q000473:pathology; D005109:Extracellular Matrix / Q000378:metabolism; D005145:Face / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007834:Lasers; D019651:Plastic Surgery Procedures; D012060:Rejuvenation; D040521:Subcutaneous Tissue / Q000473:pathology