title: Nonoperative management for perforated peptic ulcer: who can benefit?
abstract: BACKGROUND
  Although nonoperative management for perforated peptic ulcer (PPU) has been used for several decades, the indication is still unclear. A clinicoradiological score was sought to predict who can benefit from it.
  
  
  METHODS
  A clinicoradiological protocol for the assessment of patients presenting with PPU was used. A logistic regression model was applied to identify determinant variables and construct a clinical score that would identify patients who can be successfully treated with nonoperative management.
  
  
  RESULTS
  Of 241 consecutive patients with PPU, 107 successfully received nonoperative management, and 134 required surgery. In multivariable analysis, the following four variables correlated with surgery and were given one point each toward the clinical score: age ≥70 years, fluid collection detection by ultrasound, contrast extravasation detection by water-soluble contrast examination, and Acute Physiology and Chronic Health Evaluation II (APACHE II) score ≥8. Eighty-five percent of patients with a score of 1 or less were successfully treated with nonoperative management, whereas 23 of 29 patients with a score of 3 or more required surgery. The area under the receiver operating characteristic curve was 0.804 (95% confidence interval = 0.717-0.891).
  
  
  CONCLUSIONS
  By combining clinical, radiological parameters, and APACHE II score, the clinical score allowed early identification of PPU patients who can benefit from nonoperative management.
authors.affiliation: Department of General Surgery, Xuanwu Hospital, Capital Medical University, Number 45, Changchun Street, Beijing 100053, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Cao
authors.affiliation: Department of General Surgery, Xuanwu Hospital, Capital Medical University, Number 45, Changchun Street, Beijing 100053, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of General Surgery, Xuanwu Hospital, Capital Medical University, Number 45, Changchun Street, Beijing 100053, PR China.
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.affiliation: Department of General Surgery, Xuanwu Hospital, Capital Medical University, Number 45, Changchun Street, Beijing 100053, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Fang
authors.affiliation: Department of General Surgery, Xuanwu Hospital, Capital Medical University, Number 45, Changchun Street, Beijing 100053, PR China.
authors.forename: Ya-Jun
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Department of General Surgery, Xuanwu Hospital, Capital Medical University, Number 45, Changchun Street, Beijing 100053, PR China. Electronic address: feili36@ccmu.edu.cn.
authors.forename: Fei
authors.initials: F
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010439:Peptic Ulcer Perforation / Q000188:drug therapy / Q000628:therapy*
keywords: perforated peptic ulcer; surgery; treatment