title: Comparison of pemetrexed and docetaxel as salvage chemotherapy for the treatment for nonsmall-cell lung cancer after the failure of epidermal growth factor receptor-tyrosine kinase inhibitors.
abstract: OBJECTIVE
  To compare the therapeutic effects and adverse reactions of pemetrexed and docetaxel as salvage chemotherapy in patients with nonsmall-cell lung cancer (NSCLC) after the failure of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKI).
  
  
  METHODS
  In this randomized Phase 2 trial, patients with NSCLC who had previously failed EGFR-TKI therapy were randomized to receive intravenous pemetrexed (500 mg/m(2) for 21 days [one cycle]) or docetaxel (75 mg/m(2) for 21 days [one cycle]). Therapeutic effects were evaluated according to Response Evaluation Criteria in Solid Tumours standards and adverse effects were evaluated according to the US National Cancer Institute Common Terminology Criteria for Adverse Events.
  
  
  RESULTS
  There was no statistically significant difference in disease control rate, response rate, median survival and 1-year survival between treatment groups. Rates of nausea, myelosuppression, renal damage and hair loss were significantly higher in the docetaxel group than the pemetrexed group.
  
  
  CONCLUSIONS
  Pemetrexed is effective and well tolerated as salvage chemotherapy in patients with NSCLC after EGFR-TKI failure and may be a suitable therapeutic option in these patients.
authors.affiliation: Oncology Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Zhao-feng
authors.initials: ZF
authors.lastname: Han
authors.forename: Zi-hui
authors.initials: ZH
authors.lastname: Feng
authors.forename: Zhi-yang
authors.initials: ZY
authors.lastname: Jia
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D000077143:Docetaxel; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D005260:Female; D005971:Glutamates / Q000008:administration & dosage; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000068437:Pemetrexed; D016879:Salvage Therapy; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D005971:Glutamates; D043823:Taxoids; D000068437:Pemetrexed; D000077143:Docetaxel; D006147:Guanine; D066246:ErbB Receptors
keywords: Pemetrexed; docetaxel; epidermal growth factor receptor-tyrosine kinase inhibitor; nonsmall-cell lung cancer