title: Amides in one pot from carboxylic acids and amines via sulfinylamides.
abstract: An efficient method has been developed for the direct amidification of carboxylic acids via sulfinylamides preformed in situ by the reaction of pure amines with prop-2-ene-1-sulfinyl chloride. The method can be applied to aliphatic acids, including pivalic acid, aromatic acids, and primary and secondary amines. It is compatible with acids bearing unprotected alcohol, phenol, and ketone moieties and applicable to the synthesis of peptides. It does not induce their α-epimerization.
authors.affiliation: Laboratoire de Glycochimie et de Synthèse Asymétrique, Swiss Federal Institute of Technology (EPFL) , Batochime, CH 1015 Lausanne, Switzerland.
authors.forename: Jianfei
authors.initials: J
authors.lastname: Bai
authors.forename: Bartosz K
authors.initials: BK
authors.lastname: Zambroń
authors.forename: Pierre
authors.initials: P
authors.lastname: Vogel
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D007659:Ketones; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013454:Sulfoxides / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D002264:Carboxylic Acids; D007659:Ketones; D010455:Peptides; D013454:Sulfoxides