title: Pharmaceutical hydrates under ambient conditions from high-pressure seeds: a case study of GABA monohydrate.
abstract: The monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4-0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.
authors.affiliation: GZG, Abteilung Kristallographie, Georg-August-Universität Göttingen, Göttingen, 37077, Germany. ffabbia@gwdg.de.
authors.forename: Francesca P A
authors.initials: FP
authors.lastname: Fabbiani
authors.forename: Gernot
authors.initials: G
authors.lastname: Buth
authors.forename: Demetrius C
authors.initials: DC
authors.lastname: Levendis
authors.forename: Aurora J
authors.initials: AJ
authors.lastname: Cruz-Cabeza
mesh_terms: D008958:Models, Molecular; D008968:Molecular Conformation; D011312:Pressure; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*; D005680:gamma-Aminobutyric Acid / Q000737:chemistry*
chemical_list: D014867:Water; D005680:gamma-Aminobutyric Acid