title: [Discrepancies in the histological grade of submucosal gastric carcinoma between biopsy and postoperative resected specimens].
abstract: OBJECTIVE
  This study was designed to evaluate the discrepancies in the histological grade of submucosal (SM) gastric carcinoma between biopsy and resected specimens graded using the Japanese classification of gastric carcinoma (JCGC) and TNM classifications.
  
  
  METHODS
  This study comprised 250 consecutive paired biopsy and curative gastrectomy resection specimens from SM gastric carcinomas obtained between 1995 and 2011.
  
  
  RESULTS
  Of the 250 SM gastric carcinomas, 47 (19%) were smaller than 1.5 cm. Of 32 biopsy specimens diagnosed as differentiated type according to the JCGC classification, only 1 (3.1%) was eventually diagnosed as undifferentiated type according to the resected specimen. In contrast, of 25 biopsy specimens diagnosed as differentiated type according to the TNM classification, 2 (8.0%) were eventually diagnosed as undifferentiated type according to the resected specimens. These specimens were all mixed-type carcinomas.
  
  
  CONCLUSIONS
  Mixed-type gastric carcinoma is associated with a high incidence of histological discrepancy between biopsy and resected specimens in both JCGC and TNM classification. For mixed-type gastric carcinoma in particular, the treatment strategy selected from the limited treatments options available should be based on the histological grade according to biopsy specimens.
authors.affiliation: Division of Digestive Surgery, Dept. of Surgery, Kyoto Prefectural University of Medicine.
authors.forename: Mahito
authors.initials: M
authors.lastname: Miyamae
authors.forename: Shuhei
authors.initials: S
authors.lastname: Komatsu
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ichikawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kubota
authors.forename: Kazuma
authors.initials: K
authors.lastname: Okamoto
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Konishi
authors.forename: Ryou
authors.initials: R
authors.lastname: Morimura
authors.forename: Yasutoshi
authors.initials: Y
authors.lastname: Murayama
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shiozaki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kuriu
authors.forename: Hisashi
authors.initials: H
authors.lastname: Ikoma
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Nakanishi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Fujiwara
authors.forename: Chouhei
authors.initials: C
authors.lastname: Sakakura
authors.forename: Eigo
authors.initials: E
authors.lastname: Otsuji
mesh_terms: D001706:Biopsy; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000473:pathology* / Q000601:surgery; D006801:Humans; D060787:Neoplasm Grading; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery