title: [Comparative study of the effects of 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate and heparin on blood coagulation].
abstract: The purpose of this work investigation to study the effect of 4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate (thiazoline ammonium butenoate, compound FS 169) and heparin on the coagulation of whole rabbit blood in vitro and in vivo. The effects of heparin and FS 169 were investigated using a Minilab 701 coagulometer. Citrated (3.8%) blood of outbred rabbits was used in a volumetric ratio of 9 : 1. In the experiments in vivo, heparin and FS 169 were introduced subcutaneously. The results showed that FS 169 in vitro reduced the blood clotting time 3.8 times; in vivo, this compound in a dose of 1/40 LD50 decreased the clotting time 2 times within 30 min after introduction. The drug effect upon subcutaneous administration lasted for 2 h. The activity of FS 169 both in vitro and in vivo was comparable with the activity of heparin.
authors.forename: A V
authors.initials: AV
authors.lastname: Starkova
authors.forename: F B
authors.initials: FB
authors.lastname: Sobin
authors.forename: B Ia
authors.initials: BIa
authors.lastname: Syropiatov
authors.forename: N A
authors.initials: NA
authors.lastname: Pulina
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D011817:Rabbits; D014753:Vinyl Compounds / Q000494:pharmacology*; D014914:Whole Blood Coagulation Time
chemical_list: C586859:4-chlorophenyl-2-hydroxy-4-oxo-2-butenoate; D000085:Acetates; D000925:Anticoagulants; D001555:Benzene Derivatives; D014753:Vinyl Compounds; D006493:Heparin