title: [Relationship between maintenance dosages of fluindione (Préviscan) and warfarin (Coumadin) for patients 70 years and older].
abstract: BACKGROUND
  Switching from fluindione, an indanedione vitamin K antagonist derivative, to warfarin, a coumarin one, or vice versa, requires to know the relationships between dosages of these two molecules.
  
  
  METHODS
  We conducted a prospective study in 288 consecutive patients aged 70 years and over, converted from fluindione to warfarin. Patients who were retained for the analysis were those for whom maintenance dosages were obtained for both vitamin K antagonists.
  
  
  RESULTS
  Eighty-two patients, mean aged 83 ± 6 years, were analysed. The average daily maintenance dosages were 13.8 ± 6.7 mg (range 5-35) and 3.7 ± 1.7 mg (range 1-8) for fluindione and warfarin, respectively. Using a linear regression model, we built a transition algorithm for the maintenance dosages of warfarin and fluindione.
  
  
  CONCLUSIONS
  This is the first study to propose a conversion algorithm to help prescribers to estimate the maintenance dosage when it is necessary for a patient to switch from fluindione to warfarin or conversely.
authors.affiliation: Service de court séjour gériatrique, hôpital Charles-Foix, groupe hospitalier Pitié-Salpêtrière Charles-Foix (AP-HP), 7, avenue de la République, 94205 Ivry-sur-Seine, France; UFR Pierre-et-Marie-Curie, université Paris 6, 75013 Paris, France; Inserm UMR-S-765, université Paris Descartes, Sorbonne Paris-Cité, 75006 Paris, France. Electronic address: eric.pautas@cfx.aphp.fr.
authors.forename: É
authors.initials: É
authors.lastname: Pautas
authors.affiliation: Pharmacie, hôpital Charles-Foix, groupe hospitalier Pitié-Salpêtrière Charles-Foix (AP-HP), 94205 Ivry-sur-Seine, France.
authors.forename: I
authors.initials: I
authors.lastname: Peyron
authors.affiliation: Inserm UMR-S-765, université Paris Descartes, Sorbonne Paris-Cité, 75006 Paris, France; Service d'hématologie biologique, hôpital Cochin (AP-HP), 75005 Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Gouin-Thibault
authors.affiliation: Service de court séjour gériatrique, hôpital Charles-Foix, groupe hospitalier Pitié-Salpêtrière Charles-Foix (AP-HP), 7, avenue de la République, 94205 Ivry-sur-Seine, France.
authors.forename: A
authors.initials: A
authors.lastname: Gouronnec
authors.affiliation: Service de court séjour gériatrique, hôpital Charles-Foix, groupe hospitalier Pitié-Salpêtrière Charles-Foix (AP-HP), 7, avenue de la République, 94205 Ivry-sur-Seine, France.
authors.forename: A
authors.initials: A
authors.lastname: Monti
authors.affiliation: Laboratoire d'hématologie, hôpital Charles-Foix, groupe hospitalier Pitié-Salpêtrière Charles-Foix (AP-HP), 94205 Ivry-sur-Seine, France.
authors.forename: S
authors.initials: S
authors.lastname: Bouhadiba
authors.affiliation: Laboratoire d'hématologie, hôpital Charles-Foix, groupe hospitalier Pitié-Salpêtrière Charles-Foix (AP-HP), 94205 Ivry-sur-Seine, France.
authors.forename: C
authors.initials: C
authors.lastname: Badie
authors.affiliation: Département de biostatistiques, groupe hospitalier Pitié-Salpêtrière Charles-Foix (AP-HP), 75013 Paris, France.
authors.forename: J-L
authors.initials: JL
authors.lastname: Golmard
authors.affiliation: Inserm UMR-S-765, université Paris Descartes, Sorbonne Paris-Cité, 75006 Paris, France; Service d'hématologie biologique, hôpital européen Georges-Pompidou (AP-HP), 75015 Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Siguret
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism; D000465:Algorithms; D000925:Anticoagulants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D054796:Drug Dosage Calculations; D057915:Drug Substitution; D005260:Female; D006801:Humans; D008297:Male; D049451:Nomograms; D010630:Phenindione / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D013810:Therapeutic Equivalency; D013927:Thrombosis / Q000378:metabolism / Q000517:prevention & control*; D014859:Warfarin / Q000008:administration & dosage* / Q000493:pharmacokinetics
chemical_list: D000925:Anticoagulants; D010630:Phenindione; D014859:Warfarin; C017673:fluindione
keywords: Antivitamine K; Dosage; Fluindione; Posologie; Vitamin K antagonist; Warfarin; Warfarine