title: Co-delivery of dexamethasone and green tea polyphenols using electrospun ultrafine fibers for effective treatment of keloid.
abstract: OBJECTIVE
  The electrospun polymer ultrafine fiber meshes wereused to co-deliver dexamethasone (DEX) and green tea polyphenols (GTP) in order to acquire a suitable balance between effective treament of keloid and safety to the skin.
  
  
  METHODS
  This co-delivery system was prepared with a simple electrospinning technology. Keloid model was established on the back of athymic nude mice with the human keloid tissues and the formulated fiber meshes were applied onto keloids for an in vivo evaluation on their therapeutic effects.
  
  
  RESULTS
  Unlike other therapeutic formulations, these fiber meshes as a new surgical dressing possess multiple useful functions, including the capabilities of maintaining a moist environment, resisting bacterial infection and controlling the drug release. Hydrophobic DEX molecules inside the fiber meshes can be released successfully from the channels formed by the early release of the hydrophilic GTP molecules and then transported across the skin. A distinctive result acquired from histological analysis shows that after 3-month treatment, the DEX/GTP-loaded fiber meshes significantly induce the degradation of collagen fibers in keloid on the back of nude mice compared to the traditional treatment.
  
  
  CONCLUSIONS
  The dressing formulation based on nanofibers provides a promising platform for the treatment of keloid.
authors.affiliation: School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, People's Republic of China.
authors.forename: Jinrong
authors.initials: J
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Fu
authors.forename: Long
authors.initials: L
authors.lastname: Li
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Shan
authors.initials: S
authors.lastname: Ding
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Zhong
authors.forename: Shaobing
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001458:Bandages; D002478:Cells, Cultured; D003907:Dexamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007627:Keloid / Q000188:drug therapy* / Q000473:pathology; D019344:Lactic Acid / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D059808:Polyphenols / Q000008:administration & dosage* / Q000627:therapeutic use; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013662:Tea / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D059808:Polyphenols; D013662:Tea; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003907:Dexamethasone