title: [A case of locally advanced gastric cancer in which pathological complete response( PCR) was obtained after combination chemotherapy with S-1/cisplatin].
abstract: A 72-year-old man with advanced gastric cancer was referred to our hospital. Upper gastrointestinal endoscopy revealed a type 3 tumor in the gastric antrum and pyloric stenosis. Computed tomography( CT) demonstrated that the tumor had directly infiltrated the pancreatic parenchyma and that the paraaortic lymph nodes were enlarged. We judged the tumor to be unresectable and performed gastrojejunostomy. Postoperatively, the patient was treated with 9 courses of combination chemotherapy comprising S-1 and cisplatin( CDDP), and significant tumor reduction was obtained. Therefore, we performed radical distal gastrectomy with D2 lymphadenectomy. Histological examination revealed a complete absence of cancer cells in the stomach and all of the lymph nodes( pathological complete response: pCR). Seven months after surgery, the patient is in good health with no recurrence. This case suggests that aggressive chemotherapy can be a useful treatment to enable radical surgery for unresectable locally advanced gastric cancer.
authors.affiliation: Dept. of Hepato-Gastrointestinal Surgery, Odawara Municipal Hospital.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Fujino
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kametaka
authors.forename: Hironobu
authors.initials: H
authors.lastname: Makino
authors.forename: Motoaki
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Megumi
authors.initials: M
authors.lastname: Matsuo
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Seike
authors.forename: Takashi
authors.initials: T
authors.lastname: Koyama
authors.forename: Akio
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D015390:Gastric Bypass; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D010094:Oxonic Acid / Q000008:administration & dosage; D010179:Pancreas / Q000473:pathology; D011707:Pyloric Stenosis / Q000209:etiology / Q000601:surgery; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin