title: The microtubule associated protein tau H1 haplotype and risk of essential tremor.
abstract: OBJECTIVE
  Two recent studies investigated the association of the microtubule associated protein tau (MAPT) H1 haplotype, a known risk factor for neurodegenerative disease including progressive supranuclear palsy and Parkinson's disease (PD), with essential tremor (ET).
  
  
  METHODS
  To confirm this association in a different population the distribution of allele and genotype frequencies for the MAPT H1/H2 tagging single-nucleotide polymorphism (SNP) rs1052553 in ET cases and controls enrolled in a clinical-epidemiological study of ET at Columbia University was analyzed.
  
  
  RESULTS
  Overall, no association was observed between ET and the MAPT H1 haplotype. The analysis was also restricted to clinical subtypes including early-onset (≤40 years of age), Ashkenazi Jewish ancestry, white non-Ashkenazi, or ET cases with a 'definite' or 'probable/possible' diagnosis; none of these stratified analyses showed evidence of association with ET. A meta-analysis of the H1/H2 tagging SNP rs1052553 in published data sets and the H1 haplotype with risk for ET in the current study was also performed and did not find evidence for association.
  
  
  CONCLUSIONS
  The inconsistent reports of association of MAPT H1 in three emerging studies (our own and two published studies) may reflect sampling issues and/or clinical heterogeneity in these populations.
authors.affiliation: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY, USA; Center for Human Genetics, Columbia University, New York, NY, USA.
authors.forename: L N
authors.initials: LN
authors.lastname: Clark
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: N L
authors.initials: NL
authors.lastname: Parmalee
authors.forename: N
authors.initials: N
authors.lastname: Hernandez
authors.forename: E D
authors.initials: ED
authors.lastname: Louis
mesh_terms: D016022:Case-Control Studies; D020329:Essential Tremor / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins
keywords: candidate genes; case−control study; essential tremor; microtubule associated protein tau; single nucleotide polymorphisms