title: L-thyroxine stabilizes autoimmune inflammatory process in euthyroid nongoitrous children with Hashimoto's thyroiditis and type 1 diabetes mellitus.
abstract: OBJECTIVE
  To investigate if L-thyroxine (T4) treatment may influence the clinical course of autoimmune thyroiditis (AIT) or prevent progression to subclinical or overt hypothyroidism in euthyroid nongoitrous pediatric patients with type 1 diabetes mellitus (T1DM) and AIT.
  
  
  METHODS
  The study was performed in four Polish pediatric diabetes centers. Of 330 children with T1DM and AIT followed between 2008 and 2012, 101 received L-T4 and 160 underwent clinical observation for 24 months. Thyroid stimulating hormone (TSH), free T4 (fT4), anti thyroid peroxidase antibody (anti-TPO), anti thyroglobulin antibody (anti-TG), glycosylated hemoglobin (HbA1c) levels, and lipid profile were assessed in all patients. Ultrasonographic evaluation was also performed in all children at each examination.
  
  
  RESULTS
  Patients treated with thyroid hormones had higher TSH levels (3.99; interquantile 3.5 to 4.52 vs. 2.09 mIU/L; interquantile 1.55 to 3.06; pp<0.0001). A fall in TSH level (0.87 mIU/L 95% CI 0.43-1.30; pp<0.0001) was documented after the first year of treatment. FT4 level did not differ between the groups at baseline (p=0.7434), but rose in the treatment group and fell in the control group [mean difference 0.78 95% CI-0.22-1.53 pmol/L (p=0.02) after 12 months and 0.98 95% CI 0.04-1.76 (p=0.005) after 24 months]. Higher levels of anti-TPO were initially found in the treated patients (pp<0.0001) and significantly decreased over the 24-month period (pp<0.0001). Children in the treatment group had higher anti-TG levels (pp<0.0001), which showed a borderline decrease (p=0.08) in time. In the control group, anti-TG levels rose marginally (p=0.06) during the study.
  
  
  CONCLUSIONS
  The data demonstrate that treatment with L-T4 in euthyroid pediatric patients with T1DM and AIT stabilizes autoimmune inflammation in the thyroid gland and is to be recommended as soon as the diagnosis is established.
authors.affiliation: Medical University of Gdansk, Department of Pediatrics, Diabetology and Endocrinology, Gdansk, Poland. E-mail: kkorzeniowska@uck.gda.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Korzeniowska
authors.forename: Przemyslawa
authors.initials: P
authors.lastname: Jarosz-Chobot
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szypowska
authors.forename: Anna
authors.initials: A
authors.lastname: Ramotowska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Fendler
authors.forename: Barbara
authors.initials: B
authors.lastname: Kalina-Faska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Szadkowska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Mlynarski
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Mysliwiec
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism; D050031:Hashimoto Disease / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D016014:Linear Models; D008055:Lipids / Q000097:blood; D015999:Multivariate Analysis; D012189:Retrospective Studies; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000097:blood / Q000188:drug therapy*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D006442:Glycated Hemoglobin; D007453:Iodide Peroxidase; D008055:Lipids; D013954:Thyroglobulin; D013972:Thyrotropin; D013974:Thyroxine