title: A multicellular view of cytokinesis in epithelial tissue.
abstract: The study of cytokinesis in single-cell systems provided a wealth of knowledge on the molecular and biophysical mechanisms controlling daughter cell separation. In this review, we outline recent advances in the understanding of cytokinesis in epithelial tissues. These findings provide evidence for how the cytokinetic machinery adapts to a multicellular context and how the cytokinetic machinery is itself exploited by the tissue for the preservation of tissue function and architecture during proliferation. We propose that cytokinesis in epithelia should be viewed as a multicellular process, whereby the biochemical and mechanical interactions between the dividing cell and its neighbors are essential for successful daughter cell separation while defining epithelial tissue organization and preserving tissue integrity.
authors.affiliation: Institut Curie, UMR3215, U934, Team Polarity Division and Morphogenesis, 26 rue d'Ulm 75248 Paris cedex 05, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Herszterg
authors.affiliation: Institut Curie, UMR3215, U934, Team Polarity Division and Morphogenesis, 26 rue d'Ulm 75248 Paris cedex 05, France.
authors.forename: Diana
authors.initials: D
authors.lastname: Pinheiro
authors.affiliation: Institut Curie, UMR3215, U934, Team Polarity Division and Morphogenesis, 26 rue d'Ulm 75248 Paris cedex 05, France. Electronic address: yohanns.bellaiche@curie.fr.
authors.forename: Yohanns
authors.initials: Y
authors.lastname: Bellaïche
mesh_terms: D000199:Actins / Q000378:metabolism; D022005:Adherens Junctions / Q000378:metabolism; D000818:Animals; D015703:Antigens, CD; D015820:Cadherins; D016764:Cell Polarity; D048749:Cytokinesis; D004847:Epithelial Cells / Q000502:physiology*; D004848:Epithelium / Q000502:physiology; D006801:Humans; D040542:Mechanotransduction, Cellular; D024462:Myosin Type II / Q000378:metabolism
chemical_list: D000199:Actins; D015703:Antigens, CD; C513384:CDH1 protein, human; D015820:Cadherins; D024462:Myosin Type II
keywords: E-Cadherin; Myosin II; actin; adherens junction; epithelial polarity