title: NOD2 polymorphisms and pulmonary tuberculosis susceptibility: a systematic review and meta-analysis.
abstract: The association between NOD2 and tuberculosis (TB) risk has been reported widely, but the results of previous studies remained controversial and ambiguous. To assess the association between NOD2 polymorphisms and TB risk, a meta-analysis was performed. A literature search was conducted by using the PubMed, Ovid, ISI Web of Knowledge, Elsevier ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI). We identified the data from all articles estimating the association between NOD2 polymorphisms and TB risk. In total, 2,215 cases and 1,491 controls in 7 case-control studies were included. In meta-analysis, we found significant association between the Arg702Trp polymorphism and TB risk (OR = 0.43, 95% CI = 0.20-0.90, P = 0.02). However, no significant association was found between the Arg587Arg (OR = 1.31, 95% CI = 0.83-2.07, P = 0.25) and Gly908Arg (OR = 0.78, 95% CI = 0.21-2.87, P = 0.71) polymorphisms and TB risk. The present meta-analysis suggested that NOD2 Arg702Trp polymorphism was likely to be a protective factor for TB. However, the Arg587Arg and Gly908Arg polymorphisms might not be the genetic risk factors for TB susceptibility.
authors.affiliation: 1. Institute of Cell Biology, Zhejiang University, Hangzhou 310058, P.R. China.
authors.forename: Chong
authors.initials: C
authors.lastname: Wang
authors.affiliation: 1. Institute of Cell Biology, Zhejiang University, Hangzhou 310058, P.R. China.
authors.forename: Zhong-Liang
authors.initials: ZL
authors.lastname: Chen
authors.affiliation: 2. The First Hospital of Jiaxing, Jiaxing 314001, P.R. China.
authors.forename: Zhi-Fen
authors.initials: ZF
authors.lastname: Pan
authors.affiliation: 3. The Sixth Hospital of Shaoxing, Shaoxing 312000, P.R. China.
authors.forename: Li-Liang
authors.initials: LL
authors.lastname: Wei
authors.affiliation: 1. Institute of Cell Biology, Zhejiang University, Hangzhou 310058, P.R. China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Xu
authors.affiliation: 1. Institute of Cell Biology, Zhejiang University, Hangzhou 310058, P.R. China.
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Jiang
authors.affiliation: 1. Institute of Cell Biology, Zhejiang University, Hangzhou 310058, P.R. China.
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.affiliation: 1. Institute of Cell Biology, Zhejiang University, Hangzhou 310058, P.R. China.
authors.forename: Ze-Peng
authors.initials: ZP
authors.lastname: Ping
authors.affiliation: 1. Institute of Cell Biology, Zhejiang University, Hangzhou 310058, P.R. China.
authors.forename: Zhong-Jie
authors.initials: ZJ
authors.lastname: Li
authors.affiliation: 1. Institute of Cell Biology, Zhejiang University, Hangzhou 310058, P.R. China.
authors.forename: Ji-Cheng
authors.initials: JC
authors.lastname: Li
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D011110:Polymorphism, Genetic; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein
keywords: NOD2; Single-nucleotide polymorphism; meta-analysis; tuberculosis