title: A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain.
abstract: Cancers, such as melanoma, that are associated with immune deficiencies are a major cause of morbidity and mortality in HIV-infected patients. Once patients develop melanoma metastases to the brain, treatment is often limited to palliative surgery and/or radiation. Ipilimumab, a CTLA-4 antagonist, has been shown to improve the median survival of patients with metastatic melanoma. However, available data regarding the safety and efficacy of ipilimumab in HIV-infected patients who develop intracranial melanoma metastases is limited. Here we report our experience administering ipilimumab to a patient with HIV-AIDS who developed multiple intracranial melanoma metastases. Following treatment, our patient showed improvement in systemic tumor control without any apparent interference with antiretroviral treatment.
authors.affiliation: Departments of Neurosurgery, The Johns Hopkins University School of Medicine, Phipps 123 600 N. Wolfe Street, Baltimore, MD 21287, USA.
authors.forename: Jacob
authors.initials: J
authors.lastname: Ruzevick
authors.affiliation: University of Maryland School of Medicine, Baltimore, MD 21210, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Nicholas
authors.affiliation: Department of Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Kristin
authors.initials: K
authors.lastname: Redmond
authors.affiliation: Department of Radiation Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Kleinberg
authors.affiliation: Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Evan J
authors.initials: EJ
authors.lastname: Lipson
authors.affiliation: Departments of Neurosurgery, The Johns Hopkins University School of Medicine, Phipps 123 600 N. Wolfe Street, Baltimore, MD 21287, USA ; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Lim