title: New daily persistent headache and potential new therapeutic agents.
abstract: New daily persistent headache is a form of a chronic daily headache with a unique temporal profile. Patients can recall the exact day when their headache started. It can be one of the most refractory types of headache to treat. Recent publications have highlighted different subtypes and heterogeneity in presentation. Referring to it as a syndrome versus a distinct disorder has also been suggested. Several different classes of medications have been used for the treatment, with mixed results. The underlying pathophysiology of new daily persistent headache is unclear, but tumor necrosis factor may play a role. The clinical features, differential diagnosis and potential new therapeutic agents will be discussed.
authors.affiliation: Department of Neurology, New England Regional Headache Center, University of Massachusetts Medical School, 85 Prescott Street Suite 101, Worcester, MA, 01605, USA, sjoshi@nerhc.org.
authors.forename: Shivang G
authors.initials: SG
authors.lastname: Joshi
authors.forename: Paul G
authors.initials: PG
authors.lastname: Mathew
authors.forename: Herbert G
authors.initials: HG
authors.lastname: Markley
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D003937:Diagnosis, Differential; D020773:Headache Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid
chemical_list: D000700:Analgesics; D014409:Tumor Necrosis Factor-alpha