title: Compact Fluorescence and White Light Imaging System for Intraoperative Visualization of Nerves.
abstract: Fluorescence image guided surgery (FIGS) allows intraoperative visualization of critical structures, with applications spanning neurology, cardiology and oncology. An unmet clinical need is prevention of iatrogenic nerve damage, a major cause of post-surgical morbidity. Here we describe the advancement of FIGS imaging hardware, coupled with a custom nerve-labeling fluorophore (GE3082), to bring FIGS nerve imaging closer to clinical translation. The instrument is comprised of a 405 nm laser and a white light LED source for excitation and illumination. A single 90 gram color CCD camera is coupled to a 10 mm surgical laparoscope for image acquisition. Synchronization of the light source and camera allows for simultaneous visualization of reflected white light and fluorescence using only a single camera. The imaging hardware and contrast agent were evaluated in rats duringin situsurgical procedures.
authors.affiliation: Diagnostics and Biomedical Technologies, GE Global Research, One Research Circle, Niskayuna, NY, USA 12309.
authors.forename: Dan
authors.initials: D
authors.lastname: Gray
authors.affiliation: Diagnostics and Biomedical Technologies, GE Global Research, One Research Circle, Niskayuna, NY, USA 12309.
authors.forename: Evgenia
authors.initials: E
authors.lastname: Kim
authors.affiliation: Diagnostics and Biomedical Technologies, GE Global Research, One Research Circle, Niskayuna, NY, USA 12309.
authors.forename: Victoria
authors.initials: V
authors.lastname: Cotero
authors.affiliation: Diagnostics and Biomedical Technologies, GE Global Research, One Research Circle, Niskayuna, NY, USA 12309.
authors.forename: Paul
authors.initials: P
authors.lastname: Staudinger
authors.affiliation: Diagnostics and Biomedical Technologies, GE Global Research, One Research Circle, Niskayuna, NY, USA 12309.
authors.forename: Siavash
authors.initials: S
authors.lastname: Yazdanfar
authors.affiliation: Diagnostics and Biomedical Technologies, GE Global Research, One Research Circle, Niskayuna, NY, USA 12309.
authors.forename: Cristina Tan
authors.initials: CT
authors.lastname: Hehir
keywords: contrast agent; fluorescence imaging; image-guided surgery; nerve imaging