title: Identification of the proto-oncogene c-fos in areas of periprosthetic osteolysis around loosened hip prostheses.
abstract: Abstract Expression of the proto-oncogene c-fos was investigated by in situ hybridization and a study of the immunohistochemistry of the interfacial membranes surrounding the femoral component of failed cementless total hip arthroplasty (THA). The values of the proto-oncogene c-fos gene and protein were high in these interfacial membranes. High expression of the c-fos gene and protein was observed in the macrophage-like cells and fibroblast-like cells. However, there was little expression in multinucleated giant cells. We demonstrated the significance of the proto-oncogene c-fos in interfacial membranes - the first report of c-fos in total joint replacement failure.
authors.affiliation: Department of Orthopaedic Surgery, Daini Hospital, Tokyo Women's Medical University , 2-1-10 Nishiogu, Arakawa-ku, Tokyo 116-8567 , Japan.
authors.forename: C
authors.initials: C
authors.lastname: Chiba
authors.forename: J
authors.initials: J
authors.lastname: Chiba
authors.forename: M
authors.initials: M
authors.lastname: Oyama
authors.forename: K
authors.initials: K
authors.lastname: Inoue