title: [Determination of varenicline in the preparation Champix® with the use of two-dimensional capillary electrophoresis in connection with UV detection].
abstract: This paper deals with an analytical method based on two dimensional capillary electrophoresis (CITP-CZE coupling) with simple UV-detection for the determination of a highly effective drug - varenicline. The method was elaborated with the possibility of its future connection with an advanced detection ending - mass spectrometry. The electrolytes for the CITP (LE = 10 mM NH4Ac + 5 mM HAc + 0,05% m-HEC; TE = 10 mM HAc) and CZE (BGE = 20 mM HAc) separation of varenicline were selected considering such requirements. The UV detector was set at the constant wavelength of 237 nm. The presented CITP-CZE-UV combination enabled rapid and effective evaluation of varenicline in the dosage forms with LOD 5.92 ng/ml.
authors.forename: Juraj
authors.initials: J
authors.lastname: Piešťanský
authors.forename: Katarína
authors.initials: K
authors.lastname: Maráková
authors.forename: Lucia
authors.initials: L
authors.lastname: Veizerová
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Galba
authors.forename: Peter
authors.initials: P
authors.lastname: Mikuš
mesh_terms: D001552:Benzazepines / Q000008:administration & dosage / Q000032:analysis*; D004573:Electrolytes / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D011810:Quinoxalines / Q000008:administration & dosage / Q000032:analysis*; D000068580:Varenicline
chemical_list: D001552:Benzazepines; D004573:Electrolytes; D011810:Quinoxalines; D000068580:Varenicline