title: Newborn LpL (Ser447Stop, Asn291Ser) genotypes and the interaction with maternal genotypes influence the risk for different types of preeclampsia: modulating effect on lipid profile and pregnancy outcome.
abstract: OBJECTIVE
  To establish that newborn Ser447Stop and Asn291Ser may have interactive effects with maternal genotypes on the plasma lipoprotein levels, risk of preeclampsia as well as on the prognosis of preeclampsia.
  
  
  METHODS
  Seventy preeclamptic women and 94 normotensive pregnant women, and their newborns were genotyped using PCR-RFLP methods.
  
  
  RESULTS
  The risk of mild and severe preeclampsia was 4 (p = 0.004) and 5.18 (p = 0.001), respectively, if both the mother and newborn were carriers of the Ser447/Ser477 genotype. If both the mother and newborn were carriers of the Asn291Ser variant, the risk to develop severe preeclampsia was 6.07 (p = 0.03). Women with mild and severe preeclampsia had higher TG (p < 0.001; p < 0.001) and LDL-C levels (p = 0.008; p < 0.001) if both the mother and newborn were carriers of the Ser447/Ser447 genotype. Women with severe preeclampsia had significantly higher TG (p = 0.03) and LDL-C levels (p = 0.037) if both the mother and newborn were carriers of Asn291Ser. Newborn/maternal LpL interaction had no statistically significant influence on pregnancy outcome.
  
  
  CONCLUSIONS
  The newborn/maternal LpL interaction influences the severity of preeclampsia and modulates the lipid profile particularly in severe preeclampsia.
authors.affiliation: Department of Medical Biochemistry .
authors.forename: L M
authors.initials: LM
authors.lastname: Procopciuc
authors.forename: G
authors.initials: G
authors.lastname: Zaharie
authors.forename: G
authors.initials: G
authors.lastname: Caracostea
authors.forename: F
authors.initials: F
authors.lastname: Stamatian
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D018388:Codon, Terminator; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006785:Hospitals, University; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology*; D007231:Infant, Newborn; D008071:Lipoprotein Lipase / Q000097:blood / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D012383:Romania; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D018388:Codon, Terminator; D014280:Triglycerides; C548261:LPL protein, human; D008071:Lipoprotein Lipase