title: Metastasis-associated gene 1 promotes invasion and migration potential of laryngeal squamous cell carcinoma cells.
abstract: Overexpression of the metastasis-associated gene 1 (MTA1) has previously been found to be associated with progression of various cancer types to the metastasis stage. The function ofMTA1in laryngeal squamous cell carcinoma (LSCC) remains unclear. To explore the significance ofMTA1in the invasion and migration processes in LSCC, gene transfection and RNA interference (RNAi) were performed to study the biological function ofMTA1in the LSCC cell line, HEP-2. Results showed thatMTA1promoted the invasion, adhesion and migration behavior of LSCC cells. RNAi againstMTA1significantly decreased the malignant phenotypes of cancer cells.MTA1may be important in the process of LSCC invasion and metastasis.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China ; State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chao Yang, Beijing 100021, P.R. China.
authors.forename: Haili
authors.initials: H
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chao Yang, Beijing 100021, P.R. China.
authors.forename: Dong
authors.initials: D
authors.lastname: Yang
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chao Yang, Beijing 100021, P.R. China.
authors.forename: Haijuan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
authors.forename: Shuxin
authors.initials: S
authors.lastname: Wen
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chao Yang, Beijing 100021, P.R. China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chao Yang, Beijing 100021, P.R. China.
authors.forename: Qingchun
authors.initials: Q
authors.lastname: Luan
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chao Yang, Beijing 100021, P.R. China.
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, The First Hospital, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China.
authors.forename: Binquan
authors.initials: B
authors.lastname: Wang
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chao Yang, Beijing 100021, P.R. China.
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chao Yang, Beijing 100021, P.R. China.
authors.forename: Haili
authors.initials: H
authors.lastname: Qian
keywords: invasion; laryngeal squamous cell carcinoma; metastasis; metastasis-associated gene 1