title: Histopathologic clues for the diagnosis of Wiesner nevus.
abstract: The dermatologic hallmark of a recently described BAP1-associated cancer susceptibility syndrome is a dome-shaped nevus with distinct clinicopathological features, first delineated by Wiesner and colleagues. Here we describe the leading histopathological criteria of Wiesner nevus. Wiesner nevus is composed of various nevomelanocytic populations all showing different degrees of atypia ranging from hyperchromatic nevus cell-like to large atypical epithelioid cells. Immunohistochemically, Wiesner nevus is BAP1 negative and VE1 positive.
authors.affiliation: Department of Dermatology, Hospital Infanta Cristina, Parla, Madrid, Spain. Electronic address: mar.llamasvelasco@gmail.com.
authors.forename: Mar
authors.initials: M
authors.lastname: Llamas-Velasco
authors.affiliation: Department of Pathology, Hospital Infanta Cristina, Parla, Madrid, Spain.
authors.forename: Yosmar Carolina
authors.initials: YC
authors.lastname: Pérez-Gónzalez
authors.affiliation: Department of Dermatology of Fundación Jimenez Diaz, Madrid, Spain.
authors.forename: Luis
authors.initials: L
authors.lastname: Requena
authors.affiliation: Dermatopathologie Friedrichshafen, Friedrichshafen, Germany.
authors.forename: Heinz
authors.initials: H
authors.lastname: Kutzner
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D007150:Immunohistochemistry; D009154:Mutation; D018332:Nevus, Epithelioid and Spindle Cell / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D009508:Nevus, Pigmented / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D000090063:Proto-Oncogene Mas; D012878:Skin Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D025521:Tumor Suppressor Proteins / Q000032:analysis*; D043222:Ubiquitin Thiolesterase / Q000032:analysis*
chemical_list: C400134:BAP1 protein, human; D014408:Biomarkers, Tumor; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D025521:Tumor Suppressor Proteins; D043222:Ubiquitin Thiolesterase
keywords: B-raf; BAP1 protein; epithelioid and spindle cell; human; nevus; proto-oncogene proteins