title: The effect of bone marrow mononuclear stem cell therapy on left ventricular function and myocardial perfusion.
abstract: BACKGROUND
  Bone marrow stem cell (BMC) transfer is an emerging therapy with potential to salvage cardiomyocytes during acute myocardial infarction and promote regeneration and endogenous repair of damaged myocardium in patients with left ventricular (LV) dysfunction. We performed a meta-analysis to examine the association between administration of BMC and LV functional recovery as assessed by imaging.
  
  
  RESULTS
  Our meta-analysis included data from 32 trials comprising information on 1,300 patients in the treatment arm and 1,006 patients in the control arm. Overall, BMC therapy was associated with a significant increase in LV ejection fraction by 4.6% ± 0.7% (P < .001) (control-adjusted increase of 2.8% ± 0.9%, P = .001), and a significant decrease in perfusion defect size by 9.5% ± 1.4% (P < .001) (control-adjusted decrease of 3.8% ± 1.2%, P = .002). The effect of BMC therapy was similar whether the cells were administered via intra-coronary or intra-myocardial routes and was not influenced by baseline ejection fraction or perfusion defect size.
  
  
  CONCLUSIONS
  BMC transfer appears to have a positive impact on LV recovery in patients with acute coronary syndrome and those with stable coronary disease with or without heart failure. Most studies were small and a minority used a core laboratory for image analysis.
authors.affiliation: Division of Cardiovascular Disease, University of Alabama at Birmingham, Lyons-Harrison Research Building 314, 1900 University Blvd, Birmingham, AL, 35294, USA, ksadat01@gmail.com.
authors.forename: Kamel
authors.initials: K
authors.lastname: Sadat
authors.forename: Sameer
authors.initials: S
authors.lastname: Ather
authors.forename: Wael
authors.initials: W
authors.lastname: Aljaroudi
authors.forename: Jaekyeong
authors.initials: J
authors.lastname: Heo
authors.forename: Ami E
authors.initials: AE
authors.lastname: Iskandrian
authors.forename: Fadi G
authors.initials: FG
authors.lastname: Hage
mesh_terms: D016026:Bone Marrow Transplantation / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications / Q000503:physiopathology* / Q000628:therapy*; D003326:Coronary Circulation; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy*