title: Hypoxia and cancer cell metabolism.
abstract: The past decade has witnessed a rapid accumulation of evidence showing that hypoxic microenvironment, which is typical during cancer development, plays key roles in regulating cancer cell metabolism. In this review, we will focus on the role of hypoxic response, particularly, its master regulator hypoxia-inducible factor-1, in regulating glucose, lipid, as well as amino acid metabolism in cancer cells. We will also discuss the therapeutic opportunities by targeting specific pathways that facilitate metabolic reprogramming in cancer cells.
authors.affiliation: Innovation Center for Cell Biology, School of Life Science, University of Science and Technology of China, Hefei 230027, China.
authors.forename: De
authors.initials: D
authors.lastname: Huang
authors.forename: Chenchen
authors.initials: C
authors.lastname: Li
authors.forename: Huafeng
authors.initials: H
authors.lastname: Zhang
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D015687:Cell Hypoxia; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents; D051795:Hypoxia-Inducible Factor 1, alpha Subunit
keywords: HIF-1; cancer; hypoxia; metabolism