title: Plasma B-type natriuretic peptide (BNP) in acute Puumala hantavirus infection.
abstract: BACKGROUND
  Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome (HFRS) caused by Puumala hantavirus (PUUV). Acute infection causes transient kidney injury, permeability disorder, and fluid retention, for example.
  
  
  METHODS
  B-type natriuretic peptide (BNP) and N-terminal peptide (NT-proBNP) during NE were investigated; disease severity and development of clinical symptoms were considered.
  
  
  RESULTS
  Mean concentrations were 80.2 pg/mL and 55.2 pg/mL for BNP, and 2362.5 pg/mL and 1057.0 pg/mL for NT-proBNP in males and females, respectively. Hospitalization was 6.3 versus 5.2 days (P = 0.01) and 5.9 versus 4.4 days (P = 0.01) for patients with elevated BNP (> 100 pg/mL) or NT-proBNP (> 300 pg/mL), respectively, compared to those with normal peptide concentrations. Weight change during hospitalization was -2.8 or -0.3 kg (P <0.05) in patients with elevated or normal BNP, respectively. Heart rate (r = -0.46, P = 0.001 and r = -0.37, P = 0.01), creatinine clearance (r = -0.46, P = 0.001 and r = -0.56, P = 0.000), blood haemoglobin concentration (r = -0.55, P = 0.000 and r = -0.52, P = 0.000), and C-reactive protein (r = -0.47, P = 0.001 and r = -0.36, P = 0.01) measured when the peptide samples were collected correlated with BNP and NT-proBNP, respectively. In addition, anterior chamber depth of eye and plasma BNP (r = -0.39, P < 0.05) displayed a correlation.
  
  
  CONCLUSIONS
  BNP and NT-proBNP levels are associated with severity of several clinical features of acute NE.
authors.affiliation: Institute of Diagnostics, Department of Medical Microbiology, University of Oulu , Oulu , Finland.
authors.forename: Saara-Mari
authors.initials: SM
authors.lastname: Rajaniemi
authors.forename: Nina
authors.initials: N
authors.lastname: Hautala
authors.forename: Tarja
authors.initials: T
authors.lastname: Sironen
authors.forename: Olli
authors.initials: O
authors.lastname: Vainio
authors.forename: Olli
authors.initials: O
authors.lastname: Vapalahti
authors.forename: Antti
authors.initials: A
authors.lastname: Vaheri
authors.forename: Olli
authors.initials: O
authors.lastname: Vuolteenaho
authors.forename: Heikki
authors.initials: H
authors.lastname: Ruskoaho
authors.forename: Heikki
authors.initials: H
authors.lastname: Kauma
authors.forename: Timo
authors.initials: T
authors.lastname: Hautala
mesh_terms: D000208:Acute Disease; D000328:Adult; D005123:Eye / Q000503:physiopathology; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000097:blood* / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000009:adverse effects / Q000097:blood*; D011446:Prospective Studies; D011498:Protein Precursors / Q000009:adverse effects / Q000097:blood; D029262:Puumala virus / Q000472:pathogenicity*; D014882:Water-Electrolyte Balance
chemical_list: D011498:Protein Precursors; D020097:Natriuretic Peptide, Brain