title: Implication of HLA-G 3' untranslated region polymorphisms in human papillomavirus infection.
abstract: Human papillomavirus (HPV) infection is involved in cervical lesion development. It interferes with host immune response and modifies the expression of human leukocyte antigen-G (HLA-G), a nonclassical HLA-I antigen with immune-inhibitory functions. We analyzed the frequencies of two HLA-G 3' untranslated region polymorphisms (14 bp ins/del, +3142C>G), involved in HLA-G modulation, in 33 condyloma acuminatum, 14 low grade squamous intraepithelial lesion and 100 invasive cervical cancer (ICC) HPV infected patients. We showed the involvement of HLA-G polymorphisms in HPV infection and lesion development, and suggested that 14 bp del allele promotes high-risk HPV infection, with del/C haplotype associated with ICC development. On the basis of these evidences, HLA-G polymorphisms could represent a risk factor in HPV positive subjects.
authors.affiliation: Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Bortolotti
authors.forename: V
authors.initials: V
authors.lastname: Gentili
authors.forename: A
authors.initials: A
authors.lastname: Rotola
authors.forename: D
authors.initials: D
authors.lastname: Di Luca
authors.forename: R
authors.initials: R
authors.lastname: Rizzo
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D003218:Condylomata Acuminata / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000821:virology; D005260:Female; D020022:Genetic Predisposition to Disease; D059951:HLA-G Antigens / Q000235:genetics* / Q000276:immunology; D006239:Haplotypes; D006801:Humans; D018307:Neoplasms, Squamous Cell / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000821:virology; D030361:Papillomavirus Infections / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000821:virology; D011110:Polymorphism, Genetic; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000276:immunology / Q000473:pathology / Q000821:virology
chemical_list: D020413:3' Untranslated Regions; D059951:HLA-G Antigens
keywords: human leukocyte antigen-G; human papillomavirus; invasive cervical cancer