title: Development and mechanism of an enantioselective bromocycloetherification reaction via Lewis base/chiral Brønsted acid cooperative catalysis.
abstract: The development of a binary catalyst system for bromocycloetherification, consisting of an achiral Lewis base and a chiral Brønsted acid, is described in detail. The results of preliminary kinetic studies are also presented.
authors.affiliation: Department of Chemistry, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
authors.forename: Scott E
authors.initials: SE
authors.lastname: Denmark
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Burk
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D004987:Ethers / Q000737:chemistry*; D007700:Kinetics; D058116:Lewis Acids / Q000737:chemistry*; D058115:Lewis Bases / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000475:Alkenes; D004987:Ethers; D058116:Lewis Acids; D058115:Lewis Bases; D010756:Phosphoric Acids; C030242:phosphoric acid
keywords: Lewis base; cooperative catalysis; enantioselective; halofunctionalization