title: Stereotactic body radiation therapy (SBRT) for early stage lung cancer delivers clinically significant radiation to the draining lymph nodes.
abstract: BACKGROUND
  To evaluate clinically significant radiotherapy (RT) dose to draining lymph nodes (LN) in patients treated with SBRT.
  
  
  RESULTS
  Early stage non-small cell lung cancer patients treated with SBRT were selected for analysis. Patients received SBRT if they were not considered eligible for surgical resection. RT plans for 29 patients (32 lesions) were analyzed. For each patient, ipsilateral and contralateral levels 2, 3, 4, 5, 6, 7 and ipsilateral hilar LN stations were contoured. Dose volume histograms and dosimetric coverage of each lymph node region were obtained for each patient. There were 14 males and 15 females. Median age was 75 (range 60-89). Clinically significant RT was received at the corresponding draining lymph node station depending on the primary tumor location. Friedman's non-parametric test revealed a statistically significant difference in RT dose to LN stations depending on the location of the tumor (p<0.0001).
  
  
  CONCLUSIONS
  SBRT for early stage lung cancer results in significant RT dose to the draining LN. This RT dose may be sufficient to eliminate subclinical microscopic disease despite being a highly conformal treatment. Prospective studies are needed to evaluate if SBRT is comparable to lobectomy plus mediastinal lymph node dissection as a treatment option.
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: Bhupesh
authors.initials: B
authors.lastname: Parashar
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: Prabhsimranjot
authors.initials: P
authors.lastname: Singh
authors.affiliation: Division of Biostatistics and Epidemiology, Department of Public Health, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Christos
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: Shruthi
authors.initials: S
authors.lastname: Arora
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: Prashant
authors.initials: P
authors.lastname: Desai
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: A Gabriella
authors.initials: AG
authors.lastname: Wernicke
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: Marylynn
authors.initials: M
authors.lastname: Delamerced
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: Dustin
authors.initials: D
authors.lastname: Boothe
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: Dattatreyudu
authors.initials: D
authors.lastname: Nori
authors.affiliation: Stich Radiation Center, Weill Cornell Medical Center, New York, New York, USA.
authors.forename: Ksc
authors.initials: K
authors.lastname: Chao
keywords: incidental; lung; lymph nodes; radiation; stereotactic; therapeutic