title: Black women with polycystic ovary syndrome (PCOS) have increased risk for metabolic syndrome and cardiovascular disease compared with white women with PCOS [corrected].
abstract: OBJECTIVE
  To determine the prevalence of metabolic syndrome (MetSyn) and Framingham cardiovascular disease (CVD) risk in white and black adolescents and adult women with polycystic ovary syndrome (PCOS) compared with controls.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Center for PCOS.
  
  
  METHODS
  Subjects with PCOS with data on race and cardiometabolic risk (n = 519). Controls were age and race matched from the National Health and Nutrition Examination Survey (NHANES) population (1999-2006).
  
  
  METHODS
  None.
  
  
  METHODS
  MetSyn, coronary heart disease risk, and general CVD risk.
  
  
  RESULTS
  Black adolescents and young adults with PCOS had an increased prevalence of MetSyn compared with their white counterparts (adolescents relative risk 2.65 [95% confidence interval 1.29-5.4], adults relative risk 1.44 [95% confidence interval 1.21-2.6]). In contrast, there was no difference in risk of MetSyn between black and white adolescents and adult women in the NHANES dataset. After controlling for age and body mass index, black women with PCOS had a significantly increased prevalence of low high-density lipoprotein and high glucose. The general CVD risk was significantly increased in black adults with PCOS.
  
  
  CONCLUSIONS
  This is the first study to comprehensively demonstrate increased risk of MetSyn in both black adolescents and adult women with PCOS compared with white subjects with PCOS. This racial disparity was not present in the NHANES controls. Longitudinal studies are needed to assess the independent impact of PCOS and race on CVD risk in women.
authors.affiliation: Langone Medical Center, New York, New York.
authors.forename: Jennifer K
authors.initials: JK
authors.lastname: Hillman
authors.affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Lauren N C
authors.initials: LN
authors.lastname: Johnson
authors.affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Meghana
authors.initials: M
authors.lastname: Limaye
authors.affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Feldman
authors.affiliation: Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania.
authors.forename: Mary
authors.initials: M
authors.lastname: Sammel
authors.affiliation: Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: adokras@obgyn.upenn.edu.
authors.forename: Anuja
authors.initials: A
authors.lastname: Dokras
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000208:ethnology*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000208:ethnology*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000208:ethnology*; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000208:ethnology*; D012189:Retrospective Studies; D012307:Risk Factors; D044465:White People / Q000208:ethnology*; D055815:Young Adult
keywords: CVD risk; PCOS; metabolic syndrome; racial disparities