title: Focal nodular hyperplasia-like lesion of the liver with focal adenoma features associated with idiopathic portal hypertension.
abstract: Great progress has been made in the diagnosis of focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) in the last few years due to the use of molecular criteria. This has allowed us to identify a new type of hepatic nodule. In this case report, we present a male patient with a hepatic nodule associated with idiopathic portal hypertension (IPH) pathologically exhibiting not only the morphological features of FNH, such as ductular reactions, dilated sinusoids, major vascular abnormalities and an immunohistochemical "map-like" pattern of glutamine synthetase (GS), but also the immunohistological features of focal HCA, such as strong expression of serum amyloid A and C-reactive protein and weak expression of GS. As the final diagnosis, the nodule was identified as an FNH-like lesion with focal inflammatory hepatocellular adenoma.
authors.affiliation: Department of Gastroenterology and Hepatology, Tokyo Medical University, Tokyo, Japan.
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Fukuo
authors.initials: F
authors.lastname: Kondo
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Furuichi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Oshiro
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Nagao
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Saito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Yasuharu
authors.initials: Y
authors.lastname: Imai
authors.forename: Toshio
authors.initials: T
authors.lastname: Fukusato
authors.forename: Fuminori
authors.initials: F
authors.lastname: Moriyasu
keywords: anomalous portal tract syndrome; focal nodular hyperplasia-like lesion; idiopathic portal hypertension; inflammatory hepatocellular adenoma