title: Effects of prochlorperazine on normal vestibular ocular and perceptual responses: a randomised, double-blind, crossover, placebo-controlled study.
abstract: BACKGROUND
  The present study investigated whether prochlorperazine affects vestibulo-ocular reflex (VOR) and vestibulo-perceptual function.
  
  
  METHODS
  We studied 12 healthy naïve subjects 3 h after a single dose of oral prochlorperazine 5 mg in a randomised, placebo-controlled, double-blind, crossover study in healthy young subjects. Two rotational tests in yaw were used: (1) a threshold task investigating perceptual motion detection and nystagmic thresholds (acceleration steps of 0.5°/s(2)) and (2) suprathreshold responses to velocity steps of 90°/s in which vestibulo-ocular and vestibuloperceptual time constants of decay, as well as VOR gain, were measured.
  
  
  RESULTS
  Prochlorperazine had no effect upon any measure of nystagmic or perceptual vestibular function compared to placebo. This lack of effects on vestibular-mediated motion perception suggests that the drug is likely to act more as an anti-emetic than as an antivertiginous agent.
authors.affiliation: Division of Brain Sciences, Imperial College London, Charing Cross Hospital, London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Patel
authors.forename: Y
authors.initials: Y
authors.lastname: Nigmatullina
authors.forename: B M
authors.initials: BM
authors.lastname: Seemungal
authors.forename: J F
authors.initials: JF
authors.lastname: Golding
authors.forename: A M
authors.initials: AM
authors.lastname: Bronstein
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004311:Double-Blind Method; D005133:Eye Movements / Q000187:drug effects*; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D011346:Prochlorperazine / Q000494:pharmacology*; D012027:Reflex, Vestibulo-Ocular / Q000187:drug effects*; D014724:Vestibular Function Tests; D055815:Young Adult
chemical_list: D018492:Dopamine Antagonists; D011346:Prochlorperazine