title: Effects of resveratrol on oral squamous cell carcinoma (OSCC) cells in vitro.
abstract: OBJECTIVE
  Resveratrol has been reported to exhibit anti-cancer activity. The aim of this study was to examine the effects of resveratrol on the adhesion, migration, and invasion of the oral squamous cell carcinoma (OSCC) cell line KB cell in vitro.
  
  
  METHODS
  The effect of resveratrol on KB cell adhesion was evaluated by a MTT colorimetric assay, whereas its effects on cell migration and invasion were assessed by a Transwell assay.
  
  
  RESULTS
  The MTT assay revealed that the adhesion of KB cells treated with 100 μmol resveratrol for 1 or 2 h was decreased by 49.92 and 58.21%, respectively (P < 0.05). In the Transwell assay, the migratory and invasive abilities of KB cells treated with 100 μmol resveratrol were decreased by 43.98 and 37.69%, respectively.
  
  
  CONCLUSIONS
  Resveratrol inhibited the adhesion, migration, and invasion of OSCC cells in vitro, suggesting that it might serve as a chemopreventive agent for reducing the invasion and metastasis of OSCC.
authors.affiliation: Department of Orthodontics, The Second Affiliated Hospital, Harbin Medical University, Harbin, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Shan
authors.forename: Guo
authors.initials: G
authors.lastname: Yang
authors.forename: Wang
authors.initials: W
authors.lastname: Xiang
authors.forename: Wang
authors.initials: W
authors.lastname: Pei-jun
authors.forename: Zhang
authors.initials: Z
authors.lastname: Bin
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000517:prevention & control*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D003124:Colorimetry; D006801:Humans; D009062:Mouth Neoplasms / Q000473:pathology* / Q000517:prevention & control*; D009361:Neoplasm Invasiveness / Q000517:prevention & control; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D013267:Stilbenes; D000077185:Resveratrol