title: Primary cutaneous diffuse large B-cell lymphoma, leg type, with multiple local relapses: case presentation and brief review of literature.
abstract: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBL-LT) is a primary cutaneous B-cell lymphoma of intermediate behavior. The disease predominantly affects elderly patients. A 76-year old man presented with red to violaceous nodules in the anterior aspect of both tibias. Histology confirmed the diagnosis of PCDLBL-LT. A thorough clinical and laboratory investigation was negative for any systemic involvement. However, computed tomography of the thorax showed mediastinal lymphadenopathy. Both bone marrow aspiration and trephine did not show any evidence of bone marrow infiltration. Initially R-CHOP regimen (rituximab-cyclophosphamide, doxorubicin, vincristine, prednisone) achieved a total clearance of the lesions. Nevertheless, five months later patient presented with a relapse and was managed with palliative radiotherapy. The same treatment modality was applied for the second recurrence, as well. PCDLBL-LT affects mostly elderly patients. The consequent age related comorbidities and the frequent relapses require a strict follow up of the patients.
authors.affiliation: 2 Dermatology Department.
authors.forename: A
authors.initials: A
authors.lastname: Patsatsi
authors.affiliation: 2 Dermatology Department.
authors.forename: A
authors.initials: A
authors.lastname: Kyriakou
authors.affiliation: Department of Medical Oncology, Medical School, Aristotle University, Papageorgiou Hospital, Thessaloniki, Greece.
authors.forename: V
authors.initials: V
authors.lastname: Karavasilis
authors.affiliation: 2 Dermatology Department.
authors.forename: K
authors.initials: K
authors.lastname: Panteliadou
authors.affiliation: 2 Dermatology Department.
authors.forename: D
authors.initials: D
authors.lastname: Sotiriadis
keywords: B-cell cutaneous lymphoma; R-CHOP regimen; leg type (PCDLBL-LT); primary cutaneous diffuse large B-cell lymphoma