title: [Study on the role of western blot band profile for the detection of recent HIV infection].
abstract: OBJECTIVE
  To obtain information on HIV disease progression through western blot (WB) band profile.
  
  
  METHODS
  1466 available serum samples of newly reported HIV/AIDS cases, confirmed by WB from Dehong prefecture of Yunnan province in 2011, were tested, using the BED HIV Incidence Capture Enzyme Immunoassay (BED-CEIA) and Limiting Antigen Avidity Enzyme Immunoassay (LAg-Avidity EIA), respectively. Differences of WB band profiled between recent infections and established infections were then compared.
  
  
  RESULTS
  Infections defined as 'recent' showed lower mean antibody intensities to p17, p24, p31, gp41, p51, p55, p66, gp120 and gp160 in WB when compared to those established infections with statistical difference(P < 0.05).
  
  
  CONCLUSIONS
  These WB band profiles which were considered as 'recent' infections would include factors as:lack of antibody reactivity to gp41 antigen, with intensity scores of all bands lower than 13, and those intensity scores of antibody to env protein lower than 5 or to pol protein lower than 4.
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Yunnan 678400, China.
authors.forename: Ji-bao
authors.initials: JB
authors.lastname: Wang
authors.affiliation: Jiangxi Provincial Center for Disease Control and Prevention.
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention.
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Yu
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Yunnan 678400, China.
authors.forename: Yan-ling
authors.initials: YL
authors.lastname: Li
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Yunnan 678400, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Duan
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention.
authors.forename: Hao
authors.initials: H
authors.lastname: Yan
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Yunnan 678400, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.affiliation: Dehong Prefecture Center for Disease Control and Prevention, Yunnan 678400, China. Email: dhduansong@sina.com.
authors.forename: Song
authors.initials: S
authors.lastname: Duan
authors.affiliation: National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention. Email: jiangyan03@263.net.
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged