title: The role of inhibitor of DNA-binding 1 (ID-1) protein and angiogenesis in serous ovarian cancer.
abstract: BACKGROUND
  Overexpression of Inhibitor of DNA-binding 1 protein (ID-1) is correlated with poor prognosis in some malignancies and few studies have assessed its role in ovarian cancer. This led us to investigate its association with the microvessel density (MVD) in patients with ovarian cancer.
  
  
  METHODS
  Fifty-six patients with epithelial serous ovarian cancer were selected. The early-stage group consisted of 14 patients and the advanced-stage group comprised 42 patients. ID-1 expression and MVD were evaluated by immunohistochemistry.
  
  
  CONCLUSIONS
  The histoscore for ID-1 and MVD were significantly higher in advanced-stage cancer (p<0.05). The MVD was significantly higher in the high ID-1 expression group compared to the low ID-1 expression group (p<0.001). The mean follow-up time was 52 months. The survival period in patients with high ID-1 expression was not significantly shorter than for those with low ID-1 expression (p=0.62). The role of ID-1 protein requires further investigation.
authors.affiliation: Faculty of Medicine, Iuliu HaŢieganu University of Medicine and Pharmacy Cluj-Napoca, 4 Louis Pasteur Street, 400349 Cluj-Napoca, Romania. paulkubelac@gmail.com.
authors.forename: Milan-Paul
authors.initials: MP
authors.lastname: Kubelac
authors.forename: Bogdan
authors.initials: B
authors.lastname: Fetica
authors.forename: Ioan-Catalin
authors.initials: IC
authors.lastname: Vlad
authors.forename: Annamaria
authors.initials: A
authors.lastname: Fulop
authors.forename: Anca
authors.initials: A
authors.lastname: Popa
authors.forename: Patriciu
authors.initials: P
authors.lastname: Achimas-Cadariu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D051798:Inhibitor of Differentiation Protein 1 / Q000378:metabolism*; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: C497453:ID1 protein, human; D051798:Inhibitor of Differentiation Protein 1
keywords: ID-1; Ovarian cancer; angiogenesis; prognosis