title: Relative contribution of obesity and serum adiponectin to the development of hypertension.
abstract: OBJECTIVE
  The aim of this study was to investigate the association between serum adiponectin level and new-onset hypertension, and the relative contribution of obesity and low serum adiponectin levels to the development of hypertension in normotensive men and women.
  
  
  METHODS
  We analyzed 1553 adults (584 men and 969 women) without hypertension, aged 40-70 years, who had participated in a cohort study in both time periods from 2005 to 2008 for baseline and 2008 to 2011 for follow-up. We divided participants into sex-specific tertiles according to serum adiponectin levels. We defined the highest tertile of serum adiponectin as 'high adiponectin'. Participants were then stratified into four groups: the non-obese with high adiponectin; the non-obese with low adiponectin; the obese with high adiponectin; and the obese with low adiponectin.
  
  
  RESULTS
  During an average of 2.6 years of follow-up, 79 men (13.5%) and 99 women (10.2%) developed hypertension. Low serum adiponectin level was an independent predictor of new-onset hypertension in men (Odds Ratio[OR]: 1.99; 95% CI: 1.03-3.86). The Obese men with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.80; 95% CI: 1.35-5.81). In postmenopausal women, the obese subjects with low adiponectin had an increased risk of new-onset hypertension compared with the control group (OR: 2.41; 95% CI 1.16-5.04).
  
  
  CONCLUSIONS
  Low serum adiponectin levels were associated with an increased risk of new-onset hypertension in men and postmenopausal women.
authors.affiliation: Department of Family Medicine, CHA University College of Medicine, South Korea.
authors.forename: Dong-Hyuk
authors.initials: DH
authors.lastname: Jung
authors.affiliation: Department of Cardiology, Yonsei University Wonju College of Medicine, South Korea.
authors.forename: Jang-Young
authors.initials: JY
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Yonsei University Wonju College of Medicine, South Korea.
authors.forename: Jong-Koo
authors.initials: JK
authors.lastname: Kim
authors.affiliation: Department of Preventive Medicine, Yonsei University Wonju College of Medicine, South Korea.
authors.forename: Sang-Baek
authors.initials: SB
authors.lastname: Koh
authors.affiliation: Department of Preventive Medicine, Yonsei University Wonju College of Medicine, South Korea; Institute of Genomic Cohort, Yonsei University Wonju College of Medicine, South Korea.
authors.forename: Jong-Ku
authors.initials: JK
authors.lastname: Park
authors.affiliation: Department of Preventive Medicine, Yonsei University Wonju College of Medicine, South Korea; Institute of Genomic Cohort, Yonsei University Wonju College of Medicine, South Korea. Electronic address: balsan2@empas.com.
authors.forename: Song Vogue
authors.initials: SV
authors.lastname: Ahn
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D001794:Blood Pressure; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications*; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D052242:Adiponectin; D015415:Biomarkers
keywords: Adiponectin; CI; Epidemiology; HDL; Hypertension; KoGES-ARIRANG; LDL; NO; Obesity; Prospective study; RIA; TG; confidence intervals; high density lipoprotein cholesterol; hs-CRP; low density lipoprotein cholesterol; nitric oxide; radioimmunoassay; sensitivity C-reactive protein; the Korean Genome and Epidemiology Study on Atherosclerosis Risk of Rural Areas in the Korean General Population; triglycerides