title: Endocan--a novel inflammatory indicator in newly diagnosed patients with hypertension: a pilot study.
abstract: Endothelial dysfunction is regarded as the initial lesion in the development of atherosclerosis. Endocan, previously called endothelial cell-specific molecule 1 (ESM-1), is a new candidate immunoinflammatory marker that may be associated with cardiometabolic risk factors. Therefore, we assessed serum levels of endocan in newly diagnosed patients with untreated essential hypertension (HT). A total of 18 patients with HT and 23 normotensive control participants were included in the study. Serum endocan levels, carotid intima-media thickness (cIMT), and high-sensitivity C-reactive protein (hsCRP) were measured. Serum endocan levels were significantly higher in the HT group (P < .001). In patients with HT, serum endocan levels correlated positively with cIMT and hsCRP (r = .551, P < .001 and r = .644, P < .001, respectively). Our findings suggest that circulating endocan levels represent a new marker in patients with essential HT. Endocan may be a surrogate endothelial dysfunction marker and may have a functional role in endothelium-dependent pathological disorders.
authors.affiliation: Department of Cardiology, Eskişehir Military Hospital, Eskişehir, Turkey drsevketb@gmail.com.
authors.forename: Sevket
authors.initials: S
authors.lastname: Balta
authors.affiliation: Department of Clinical Chemistry, University College London Medical School London, University College London (UCL), United Kingdom.
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Mikhailidis
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Sait
authors.initials: S
authors.lastname: Demirkol
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.affiliation: Department of Cardiology, Malatya State Hospital, Malatya, Turkey.
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Kurtoglu
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Demir
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.affiliation: Department of Epidemiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Turker
authors.initials: T
authors.lastname: Turker
authors.affiliation: Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
authors.forename: Atila
authors.initials: A
authors.lastname: Iyisoy
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011379:Prognosis; D011509:Proteoglycans / Q000097:blood*; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; C101134:ESM1 protein, human; D018836:Inflammation Mediators; D009363:Neoplasm Proteins; D011509:Proteoglycans; D002097:C-Reactive Protein
keywords: endocan; inflammation; newly diagnosed hypertension