title: Modulatory effects of morin on hyperglycemia by attenuating the hepatic key enzymes of carbohydrate metabolism and β-cell function in streptozotocin-induced diabetic rats.
abstract: The present study was aimed to evaluate the effect of morin on blood glucose, insulin level, hepatic glucose regulating enzyme activities and glycogen level in experimental diabetes. Diabetes mellitus was induced by a single intraperitoneal injection of streptozotocin (STZ) (50 mg/kg b.w.). Five days after STZ injection, diabetic rats received morin (25 and 50 mg/kg b.w.) orally for 30 days. Glibenclamide was used as reference drug. Morin treatment significantly reduced the blood glucose and improved the serum insulin levels. Further, a dose-dependent reduction in glucose-6-phosphatase and fructose-1,6-bisphosphatase was observed along with the increase in liver hexokinase and glucose-6-phosphate dehydrogenase activities. Morin supplement were found to be effective in preserving the normal histological appearance of pancreatic islets as well as to preserve insulin-positive β-cells in STZ-rats. Therefore, these findings suggest that morin displays beneficial effects in the treatment of diabetes, mediated through the regulation of carbohydrate metabolic enzyme activities.
authors.affiliation: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India.
authors.forename: P
authors.initials: P
authors.lastname: Vanitha
authors.affiliation: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India.
authors.forename: C
authors.initials: C
authors.lastname: Uma
authors.affiliation: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India.
authors.forename: N
authors.initials: N
authors.lastname: Suganya
authors.affiliation: Department of Biotechnology, School of Bioengineering, SRM University, Kattankulathur 603 203, Tamilnadu, India.
authors.forename: E
authors.initials: E
authors.lastname: Bhakkiyalakshmi
authors.affiliation: Department of Water and Health, JSS University, Mysore 570 015, Karnataka, India.
authors.forename: S
authors.initials: S
authors.lastname: Suriyanarayanan
authors.affiliation: The King Institute of Preventive Medicine and Research, Guindy, Chennai 600 032, Tamilnadu, India.
authors.forename: P
authors.initials: P
authors.lastname: Gunasekaran
authors.affiliation: The King Institute of Preventive Medicine and Research, Guindy, Chennai 600 032, Tamilnadu, India.
authors.forename: S
authors.initials: S
authors.lastname: Sivasubramanian
authors.affiliation: SRM Research Institute, SRM University, Kattankulathur 603 203, Tamilnadu, India. Electronic address: ramkumar.km@res.srmuniv.ac.in.
authors.forename: K M
authors.initials: KM
authors.lastname: Ramkumar
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D050260:Carbohydrate Metabolism / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D006003:Glycogen / Q000378:metabolism; D006943:Hyperglycemia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D047309:Flavones
chemical_list: D001786:Blood Glucose; D005419:Flavonoids; D006003:Glycogen; D007004:Hypoglycemic Agents; D007328:Insulin; C008548:morin; D047309:Flavones
keywords: Antidiabetic activity; Carbohydrate enzymes; Morin; Natural products; STZ