title: [Effect of stability and dissolution of realgar nano-particles using solid dispersion technology].
abstract: OBJECTIVE
  To improve the stability and dissolution of realgar nano-particles by solid dispersion.
  
  
  METHODS
  Using polyethylene glycol 6000 and poloxamer-188 as carriers, the solid dispersions were prepare by melting method. XRD, microscopic inspection were used to determine the status of realgar nano-particles in solid dispersions. The content and stability test of As(2)0(3) were determined by DDC-Ag method. Hydride generation atomic absorption spectrometry was used to determine the content of Arsenic and investigated the in vitro dissolution behavior of solid dispersions.
  
  
  RESULTS
  The results of XRD and microscopic inspection showed that realgar nano-particles in solid dispersions were amorphous. The dissolution amount and rate of Arsenic from realgar nano-particles of all solid dispersions were increased significantly, the reunion of realgar nano-particles and content of As(2)0(3) were reduced for the formation of solid dispersions.
  
  
  CONCLUSIONS
  The solid dispersion of realgar nano-particles with poloxamer-188 as carriers could obviously improve stability, dissolution and solubility.
authors.affiliation: College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. guoteng1@hotmail.com
authors.forename: Teng
authors.initials: T
authors.lastname: Guo
authors.affiliation: College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.affiliation: College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Yang
authors.affiliation: College of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
authors.forename: Nian-Ping
authors.initials: NP
authors.lastname: Feng
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility
chemical_list: D004337:Drug Carriers; D004365:Drugs, Chinese Herbal; D020442:Poloxamer; D011092:Polyethylene Glycols