title: Enantioselective copper(I/II)-catalyzed conjugate addition of nitro esters to β,γ-unsaturated α-ketoesters.
abstract: A highly enantioselective Michael addition of nitroacetates to β,γ-unsaturated α-ketoesters was developed by using chiral copper catalysts. The Michael addition products can be obtained in high yields with up to 99 % ee. With these densely functionalized products, the chiral cyclic nitrones, which are important synthetic intermediates, can be obtained in one step.
authors.affiliation: Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026 (China), Fax:(+86) 551-3603185.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Xu
authors.forename: Fengfeng
authors.initials: F
authors.lastname: Guo
authors.forename: Yanbin
authors.initials: Y
authors.lastname: Hu
authors.forename: Zhenggen
authors.initials: Z
authors.lastname: Zha
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
keywords: Michael addition; asymmetric catalysis; copper; ketoesters; nitroacetate