title: Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain.
abstract: OBJECTIVE
  To investigate the effects of cannabidiol (CBD) on mitochondrial complex and creatine kinase (CK) activity in the rat brain using spectrophotometry.
  
  
  METHODS
  Male adult Wistar rats were given intraperitoneal injections of vehicle or CBD (15, 30, or 60 mg/kg) in an acute (single dose) or chronic (once daily for 14 consecutive days) regimen. The activities of mitochondrial complexes and CK were measured in the hippocampus, striatum, and prefrontal cortex.
  
  
  RESULTS
  Both acute and chronic injection of CBD increased the activity of the mitochondrial complexes (I, II, II-III, and IV) and CK in the rat brain.
  
  
  CONCLUSIONS
  Considering that metabolism impairment is certainly involved in the pathophysiology of mood disorders, the modulation of energy metabolism (e.g., by increased mitochondrial complex and CK activity) by CBD could be an important mechanism implicated in the action of CBD.
authors.affiliation: Laboratory of Neurosciences and National Science and Technology Institute for Translational Medicine (INCT-TM), Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), CriciúmaSC, Brazil.
authors.forename: Samira S
authors.initials: SS
authors.lastname: Valvassori
authors.affiliation: Laboratory of Neurosciences and National Science and Technology Institute for Translational Medicine (INCT-TM), Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), CriciúmaSC, Brazil.
authors.forename: Daniela V
authors.initials: DV
authors.lastname: Bavaresco
authors.affiliation: Laboratory of Experimental Pathophysiology and INCT-TM, Graduate Program in Health Sciences, Health Sciences Unit, UNESC, CriciúmaSC, Brazil.
authors.forename: Giselli
authors.initials: G
authors.lastname: Scaini
authors.affiliation: Laboratory of Neurosciences and National Science and Technology Institute for Translational Medicine (INCT-TM), Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), CriciúmaSC, Brazil.
authors.forename: Roger B
authors.initials: RB
authors.lastname: Varela
authors.affiliation: Laboratory of Experimental Pathophysiology and INCT-TM, Graduate Program in Health Sciences, Health Sciences Unit, UNESC, CriciúmaSC, Brazil.
authors.forename: Emilio L
authors.initials: EL
authors.lastname: Streck
authors.affiliation: Department of Neurosciences and Behavior, Division of Psychiatry, Ribeirão Preto Medical School, Universidade de São Paulo (USP), and INCT-TM, Ribeirão PretoSP, Brazil.
authors.forename: Marcos H
authors.initials: MH
authors.lastname: Chagas
authors.affiliation: Department of Neurosciences and Behavior, Division of Psychiatry, Ribeirão Preto Medical School, Universidade de São Paulo (USP), and INCT-TM, Ribeirão PretoSP, Brazil.
authors.forename: Jaime E C
authors.initials: JE
authors.lastname: Hallak
authors.affiliation: Department of Neurosciences and Behavior, Division of Psychiatry, Ribeirão Preto Medical School, Universidade de São Paulo (USP), and INCT-TM, Ribeirão PretoSP, Brazil.
authors.forename: Antonio W
authors.initials: AW
authors.lastname: Zuardi
authors.affiliation: Department of Neurosciences and Behavior, Division of Psychiatry, Ribeirão Preto Medical School, Universidade de São Paulo (USP), and INCT-TM, Ribeirão PretoSP, Brazil.
authors.forename: José A
authors.initials: JA
authors.lastname: Crippa
authors.affiliation: Laboratory of Neurosciences and National Science and Technology Institute for Translational Medicine (INCT-TM), Graduate Program in Health Sciences, Health Sciences Unit, Universidade do Extremo Sul Catarinense (UNESC), CriciúmaSC, Brazil.
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002185:Cannabidiol / Q000008:administration & dosage*; D003402:Creatine Kinase / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002185:Cannabidiol; D003402:Creatine Kinase