title: [RIFLE and AKIN criteria for mortality and risk factors of acute kidney injury in hospitalized patients].
abstract: OBJECTIVE
  To evaluate the mortality and risk factors for acute kidney injury (AKI) in hospitalized patients by the risk, injury, failure, loss, end stage kidney disease (RIFLE) and acute kidney injury network (AKIN).
  
  
  METHODS
  We constructed a retrospective study of all AKI patients in the Second Xiangya Hospital of Central South University between February 2006 and January 2011. The diagnosis and classification of AKI were reconfirmed and categorized by RIFLE and AKIN criteria. To compare the clinical characteristics, mortality and associated risk factors in AKI patients by the RIFLE and AKIN stage, univariate analysis and multivariate logistic regression analysis were performed.
  
  
  RESULTS
  The patients were diagnosed as AKI by AKIN (n=1027) or by RIFLE criteria (n=1020). There was no significant difference in the hospital mortality, hospital length stay (days), or the proportion of complete recovery in each stage of AKI patients by RIFLE and AKIN (P>0.05). In the univariate analysis, age, pre-renal causes, proportion of hospital acquired AKI, mechanical ventilation, hypotension, the number of failed organs, acute tubular necrosis-index severity score (ATN-ISS), and the peak of serum potassium ion concentration were significantly higher in the non-survivors than in the survivors (P<0.05). Logistic regression analysis revealed that age older than 65, hospital acquired AKI, hypotension, number of failed organs, ATN-ISS scores, and the peak of serum potassium ion concentration were independent risk factors for hospital mortality.
  
  
  CONCLUSIONS
  Both RIFLE and AKIN criteria have similar scientific value in assessing hospital mortality. AKI stage is associated with the recent prognosis of AKI patients.
authors.affiliation: Department of Nephrology, Second Xiangya Hospital, Central South University; Renal Stem Cell Research Laboratory, Institute of Nephrology, Central South University; Center of Kidney Disease and Dialysis in Hunan Province, Changsha 410011, China duansb528@hotmail.com.
authors.forename: Shaobin
authors.initials: S
authors.lastname: Duan
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Peng
authors.initials: P
authors.lastname: Pan
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Youming
authors.initials: Y
authors.lastname: Peng
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
authors.forename: Fuyou
authors.initials: F
authors.lastname: Liu
mesh_terms: D058186:Acute Kidney Injury / Q000145:classification / Q000175:diagnosis* / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index