title: Dramatic efficacy of cyclophosphamide pulsed therapy combined with double-filtration plasmapheresis for treating severe massive pulmonary hemorrhage associated with systemic lupus erythematosus.
abstract: Abstract Pulmonary hemorrhage (PH) is a rare but fatal complication of systemic lupus erythematosus (SLE). We report a patient with SLE and a massive PH who was treated with double-filtration plasmapheresis synchronized with cyclophosphamide pulsed therapy. The patient showed dramatic improvement immediately and was followed for 3 years without recurrence. Prompt treatment during the acute phase of PH with this short-term intensive combination therapy may offer the best chance of success. There are few reports of long-term followup, especially in Japan.
authors.affiliation: Department of Internal Medicine, Saiseikai Utsunomiya Hospital , 911-1 Takebayashi, Utsunomiya 321-0974 , Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: K
authors.initials: K
authors.lastname: Inose
authors.forename: S
authors.initials: S
authors.lastname: Horie
authors.forename: Y
authors.initials: Y
authors.lastname: Okubo
authors.forename: R
authors.initials: R
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Nakazawa
authors.forename: K
authors.initials: K
authors.lastname: Nakada