title: Changes in antimicrobial use prevalence in China: results from five point prevalence studies.
abstract: OBJECTIVE
  The abuse of antimicrobials is a serious concern in China. Several measures have been taken to improve the rational use of antimicrobials, including the establishment of a national surveillance network for antimicrobial use. This study describes the dynamic changes in antimicrobial use in China between 2001 and 2010, with the scope of identifying targets to improve the prescription of antimicrobials.
  
  
  METHODS
  Five point prevalence surveys were performed in hospitals across mainland China in 2001, 2003, 2005, 2008, and 2010. All inpatients who were admitted for at least 24 hours were included in the study. Details regarding antimicrobial use by these patients and the collection of samples for bacterial culture from inpatients administered therapeutic antimicrobials were recorded.
  
  
  RESULTS
  The surveys encompassed tertiary hospitals from all 31 provinces of mainland China. Antimicrobial use prevalence decreased from 54.79% in 2001 to 46.63% in 2010. While this decline was observed in most hospital departments, antimicrobial use remained stable or increased in others. Antimicrobial use prevalence was relatively high in the Pediatrics departments and general intensive care units, whereas it was lower in the Obstetrics (Neonatal group) departments in each survey. The proportion of patients administered a single antimicrobial increased from 60.78% in 2001 to 70.16% in 2010, while the proportion of administration of two or more antimicrobials declined. The bacterial culture rate increased from 25.22% in 2003 to 34.71% in 2010. Antimicrobial use prevalence (47.96% vs 46.16%), bacterial culture rate (36.40% vs 34.19%), and the proportion of administration of a single antimicrobial (71.41% vs 67.33%) were higher in teaching hospitals than in nonteaching hospitals in 2010.
  
  
  CONCLUSIONS
  Although measures for enhancing the rational use of antimicrobials have been effective, further improvements are required. The findings from this study can promote such improvements.
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Chunhui
authors.initials: C
authors.lastname: Li
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Ren
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ximao
authors.initials: X
authors.lastname: Wen
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Huang
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Ruie
authors.initials: R
authors.lastname: Gong
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lv
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Li
authors.initials: L
authors.lastname: Feng
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Hongman
authors.initials: H
authors.lastname: Wu
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Zhenru
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Chenchao
authors.initials: C
authors.lastname: Fu
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Huang
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Zeng
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Shuangyan
authors.initials: S
authors.lastname: Zuo
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Xinrui
authors.initials: X
authors.lastname: Xiong
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Xiuhua
authors.initials: X
authors.lastname: Xu
authors.affiliation: Infection Control Center, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Anhua
authors.initials: A
authors.lastname: Wu
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D002681:China / Q000453:epidemiology; D004359:Drug Therapy, Combination; D006761:Hospitals / Q000706:statistics & numerical data; D006784:Hospitals, Teaching / Q000706:statistics & numerical data; D006801:Humans; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D015995:Prevalence
chemical_list: D000890:Anti-Infective Agents