title: Differences in the clinical phenotype of adenomyosis and leiomyomas: a retrospective, questionnaire-based study.
abstract: OBJECTIVE
  To compare women undergoing laparoscopic hysterectomy with adenomyosis and women with leiomyomas.
  
  
  METHODS
  Retrospective and questionnaire-based study was conducted at the Department of Obstetrics and Gynecology, University Women's Clinic, Tuebingen, Germany. The study sample comprised a total of 454 women who underwent hysterectomy for adenomyosis or leiomyomas and responded to the questionnaire; 52 (11.4 %) women with a histologic diagnosis of adenomyosis and 452 (88.6 %) women with a histologic diagnosis of leiomyomas.
  
  
  RESULTS
  Both groups of patients had enlarged uteri, but women with adenomyosis had a lower mean uterine weight as compared to women with leiomyomas (p < 0.001). Women with adenomyosis had significantly more pregnancies (p = 0.003), were more likely to have more than one pregnancy (p = 0.033) or more than one delivery (p = 0.025) as compared to women with leiomyomas. In addition, women with adenomyosis had a significantly higher surgical procedure score (p = 0.017), had more frequently a history of laparotomy (p = 0.042) and a history of Cesarean section as compared to women with leiomyomas only (p = 0.024). Significantly, more women with adenomyosis had pelvic pain or pressure as compared to women with leiomyomas (p = 0.045). We observed no differences between the two groups of patients regarding pelvic pain during the menstrual period, irregular menstrual periods, heavy bleeding, painful sexual intercourse and urination problems. Furthermore, we observed no differences in the therapeutic impact of the surgical procedure between the two patient groups.
  
  
  CONCLUSIONS
  Women with a histologic diagnosis of adenomyosis differ from women who have only leiomyomas at the time of hysterectomy.
authors.affiliation: Department of Obstetrics and Gynecology, University Women's Clinic, Calwerstr. 7, 72076, Tuebingen, Germany.
authors.forename: Bettina
authors.initials: B
authors.lastname: Boeer
authors.forename: Markus
authors.initials: M
authors.lastname: Wallwiener
authors.forename: Joachim
authors.initials: J
authors.lastname: Rom
authors.forename: Birgitt
authors.initials: B
authors.lastname: Schoenfisch
authors.forename: Sara Y
authors.initials: SY
authors.lastname: Brucker
authors.forename: Florin A
authors.initials: FA
authors.lastname: Taran
mesh_terms: D062788:Adenomyosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D000328:Adult; D002585:Cesarean Section / Q000706:statistics & numerical data; D005260:Female; D005858:Germany / Q000453:epidemiology; D006112:Gravitation; D006801:Humans; D007044:Hysterectomy; D010535:Laparoscopy; D007813:Laparotomy / Q000706:statistics & numerical data; D018231:Leiomyomatosis / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D009929:Organ Size; D010298:Parity; D017699:Pelvic Pain / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D014594:Uterine Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014599:Uterus / Q000473:pathology / Q000601:surgery