title: Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity.
abstract: To improve our understanding of the biological relationships among different types of cancer, we have characterized variation in gene expression patterns in a set of 1,707 samples representing 6 human cancer types (breast, ovarian, brain, colorectal, lung adenocarcinoma and squamous cell lung cancer). In the unified dataset, breast tumors of the Basal-like subtype were found to represent a unique molecular entity as any other cancer type, including the rest of breast tumors, while showing striking similarities with squamous cell lung cancers. Moreover, gene signatures tracking various cancer- and stromal-related biological processes such as proliferation, hypoxia and immune activation were found expressed similarly in different proportions of tumors across the various cancer types. These data suggest that clinical trials focusing on tumors with common profiles and/or biomarker expression rather than their tissue of origin are warranted with a special focus on Basal-like breast cancer and squamous cell lung carcinoma.
authors.affiliation: 1] Translational Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain [2] Breast Cancer Unit, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain [3] Medical Oncology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Aleix
authors.initials: A
authors.lastname: Prat
authors.affiliation: Medical Oncology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Barbara
authors.initials: B
authors.lastname: Adamo
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.
authors.forename: Cheng
authors.initials: C
authors.lastname: Fan
authors.affiliation: 1] Pathology Department, Vall d'Hebron University Hospital, Barcelona, Spain [2] Morphological Sciences Department, Universitat Autònoma de Barcelona, Spain.
authors.forename: Vicente
authors.initials: V
authors.lastname: Peg
authors.affiliation: 1] Translational Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain [2] Breast Cancer Unit, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain [3] Medical Oncology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: Vidal
authors.affiliation: Translational Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Galván
authors.affiliation: Cancer Genomics Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Vivancos
authors.affiliation: Molecular Oncology Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Paolo
authors.initials: P
authors.lastname: Nuciforo
authors.affiliation: Stem Cells and Cancer Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Héctor G
authors.initials: HG
authors.lastname: Palmer
authors.affiliation: Department of Medical Oncology, Dubai Hospital, U.A.E.
authors.forename: Shaheenah
authors.initials: S
authors.lastname: Dawood
authors.affiliation: Medical Oncology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Rodón
authors.forename: Santiago
authors.initials: S
authors.lastname: Ramon y Cajal
authors.affiliation: Pathology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: Santiago
authors.initials: S
authors.lastname: Ramony Cajal
authors.affiliation: Medical Oncology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Josep Maria
authors.initials: JM
authors.lastname: Del Campo
authors.affiliation: Medical Oncology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Enriqueta
authors.initials: E
authors.lastname: Felip
authors.affiliation: Medical Oncology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Josep
authors.initials: J
authors.lastname: Tabernero
authors.affiliation: 1] Breast Cancer Unit, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain [2] Medical Oncology Department, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Cortés
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D015687:Cell Hypoxia / Q000235:genetics; D049109:Cell Proliferation; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D015723:Gene Library; D014644:Genetic Variation; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D018295:Neoplasms, Basal Cell / Q000235:genetics*; D018307:Neoplasms, Squamous Cell / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D059467:Transcriptome / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor