title: Cerebral vascular accidents after lumbar spine fusion.
abstract: METHODS
  Retrospective cohort.
  
  
  OBJECTIVE
  To determine the impact of a cerebral vascular accident (CVA) after lumbar spinal fusion, a population-based database was analyzed to identify the incidence, potential risk factors, hospital resource utilization, and the early postoperative outcomes.
  
  
  BACKGROUND
  A lumbar fusion (LF) is an effective surgical procedure to treat lumbar degenerative pathology. Although rare, a CVA can be a catastrophic event after an LF.
  
  
  METHODS
  The Nationwide Inpatient Sample database was queried from 2002-2011. Patients undergoing an elective anterior lumbar fusion, a posterior lumbar fusion, or a combined anterior-posterior lumbar fusion were separated into subcohorts. Patients with a documented postoperative CVA were identified. Patient demographics, comorbidities (Charlson Comorbidity Index), length of stay, costs, early postoperative outcomes, and mortality were assessed. Statistical analysis involved T tests, χ2 analysis, and binary logistic regression with P < 0.001 denoting significance.
  
  
  RESULTS
  A total of 264,891 LFs were identified between 2002 and 2011 of which 340 (1.3 per 1000) developed a postoperative CVA. Patients with a CVA were significantly older and demonstrated a greater comorbidity burden (Charlson Comorbidity Index). Patients with a CVA incurred a significantly greater length of stay, total hospital costs ($41,454 vs. $25,885), and a greater mortality rate (73.7 vs. 0.8 per 1000 patients). Regression analysis demonstrated that age more than 65 years and a history of neurological disorders, paralysis, congestive heart failure, or electrolyte imbalance were associated with an increased risk of a postoperative CVA.
  
  
  CONCLUSIONS
  Patients who developed a postoperative CVA demonstrated a significantly greater incidence of postoperative complications, mortality, and total hospital costs. This study highlights important associated risk factors (e.g., age more than 65, neurological disorders, congestive heart failure) that may enable surgeons to identify high-risk patients prior to surgery. Further studies are warranted to characterize these risk factors and to establish guidelines to mitigate the complications associated with a postoperative CVA.
  
  
  METHODS
  4.
authors.affiliation: From the Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Marquez-Lara
authors.forename: Sreeharsha V
authors.initials: SV
authors.lastname: Nandyala
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Fineberg
authors.forename: Kern
authors.initials: K
authors.lastname: Singh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D015897:Comorbidity; D017558:Elective Surgical Procedures; D005260:Female; D017721:Hospital Costs; D006801:Humans; D015994:Incidence; D007902:Length of Stay; D016015:Logistic Models; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013123:Spinal Fusion / Q000009:adverse effects* / Q000191:economics / Q000401:mortality; D020521:Stroke / Q000175:diagnosis / Q000191:economics / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D055815:Young Adult