title: Additive effect of pretransplant obesity, diabetes, and cardiovascular risk factors on outcomes after liver transplantation.
abstract: The effects of pretransplant obesity, diabetes mellitus (DM), coronary artery disease (CAD), and hypertension (HTN) on outcomes after liver transplantation (LT) are controversial. Questions have also been raised about the appropriateness of the body mass index (BMI) for assessing obesity in patients with end-stage liver disease. Both issues have implications for organ allocation in LT. To address these questions, we undertook a cohort study of 202 consecutive patients (2000-2010) undergoing LT at a national center in New Zealand. BMI and body fat percentage (%BF) values (dual-energy X-ray absorptiometry) were measured before transplantation, and the methods were compared. The influence of pretransplant risk variables (including obesity, DM, CAD, and HTN) on the 30-day postoperative event rate, length of hospital stay, and survival were analyzed. There was agreement between the calculated BMI and the measured %BF for 86.0% of the study population (κ coefficient = 0.73, 95% confidence interval = 0.61-0.85), and this was maintained across increasing Model for End-Stage Liver Disease scores. Obesity was an independent risk factor for the postoperative event rate [count ratio (CR) = 1.03, P < 0.001], as was DM (CR = 1.4, P < 0.001). Obesity with concomitant DM was the strongest predictor of the postoperative event rate (CR = 1.75, P < 0.001) and a longer hospital stay (5.81 days, P < 0.01). Independent metabolic risk factors had no effect on 30-day, 1-year, or 5-year patient survival. In conclusion, BMI is an adequate tool for assessing obesity-associated risk in LT. Early post-LT morbidity is highest for patients with concomitant obesity and DM, although these factors do not appear to influence recipient survival.
authors.affiliation: Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
authors.forename: Anna J
authors.initials: AJ
authors.lastname: Dare
authors.forename: Lindsay D
authors.initials: LD
authors.lastname: Plank
authors.forename: Anthony R J
authors.initials: AR
authors.lastname: Phillips
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Gane
authors.forename: Barry
authors.initials: B
authors.lastname: Harrison
authors.forename: David
authors.initials: D
authors.lastname: Orr
authors.forename: Yannan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Adam S J R
authors.initials: AS
authors.lastname: Bartlett
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000150:complications*; D048909:Diabetes Complications; D058625:End Stage Liver Disease / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D005260:Female; D005355:Fibrosis / Q000150:complications / Q000601:surgery; D006526:Hepatitis C / Q000150:complications / Q000601:surgery; D006801:Humans; D007902:Length of Stay; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009520:New Zealand; D009765:Obesity / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult