title: Bio-effects of non-ionizing electromagnetic fields in context of cancer therapy.
abstract: Bio-effects mediated by non-ionizing electromagnetic fields (EMF) have become a hot topic of research in the last decades. This interest has been triggered by a growing public concern about the rapid expansion of telecommunication devices and possible consequences of their use on human health. Despite a feasibility study of potential negative impacts, the therapeutic advantages of EMF could be effectively harnessed for the treatment of cancer and other diseases. This review aims to examine recent findings relating to the mechanisms of action underlying the bio-effects induced by non-ionizing EMF. The potential of non-thermal and thermal effects is discussed in the context of possible applications for the induction of apoptosis, formation of reactive oxygen species, and increase of membrane permeability in malignant cells. A special emphasis has been put on the combination of EMF with magnetic nano-particles and ultrasound for cancer treatment. The review encompasses both human and animal studies.
authors.affiliation: Department of Regenerative Medicine and Artificial Organs, PE.
authors.forename: Timur
authors.initials: T
authors.lastname: Saliev
authors.affiliation: Department of Anatomy, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Fukuoka 814-0180, Japan.
authors.forename: Katsuro
authors.initials: K
authors.lastname: Tachibana
authors.affiliation: Department of Regenerative Medicine and Artificial Organs, PE.
authors.forename: Denis
authors.initials: D
authors.lastname: Bulanin
authors.affiliation: Biomaterials and Medical Devices Research Group, School of Pharmacy and Biomedical Sciences, University of Brighton, Cockcroft Building, Lewes Road, Brighton, BN2 4GJ, United Kingdom.
authors.forename: Sergey
authors.initials: S
authors.lastname: Mikhalovsky
authors.affiliation: Nanoscience and Nanotechnology Group, Faculty of Science & Engineering, University of Brighton, Cockcroft Building, Lewes Road, Brighton, BN2 4GJ, United Kingdom.
authors.forename: Ray D L
authors.initials: RD
authors.lastname: Whitby
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D002463:Cell Membrane Permeability / Q000528:radiation effects*; D006358:Hot Temperature; D006801:Humans; D055909:Magnetic Field Therapy / Q000009:adverse effects* / Q000379:methods*; D053758:Nanoparticles / Q000627:therapeutic use; D009369:Neoplasms / Q000628:therapy*; D011840:Radiation, Nonionizing / Q000009:adverse effects*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014463:Ultrasonography / Q000379:methods
chemical_list: D017382:Reactive Oxygen Species