title: Expression level of valosin containing protein is associated with prognosis of primary orbital MALT lymphoma.
abstract: OBJECTIVE
  To investigate whether the expression level of valosin-containing protein (VCP) is correlated with the prognosis of primary orbital mucosa-associated lymphoid tissue (MALT) lymphoma.
  
  
  METHODS
  VCP expression in 58 samples from primary orbital MALT lymphoma patients was determined by immunohistochemisty using monoclonal antibodies. Correlations between VCP expression level and prognosis were clarified by statistical analysis.
  
  
  RESULTS
  It was found that the percentage of VCP positive cells in samples of primary orbital MALT lymphoma ranged from 32% to 95%. The samples were divided into two groups (level 1 and level 2) according to the median value (45%) of the percentage of VCP positive cells. It was found that the expression level of VCP was significantly correlated with recurrence (P=0.003) and tumor size (P=0.008). At the same time, the 5-year disease-free and overall survival rate of patients of level 1 was significantly better than that of level 2 (P=0.001; P=0.032). There was no observed correlation between the expression level of VCP and other clinical features.
  
  
  CONCLUSIONS
  VCP could be a useful marker for predicting the prognosis of primary orbital MALT lymphoma.
authors.affiliation: Medical College of Qingdao University, Qingdao, China E-mail : yanggg@hotmail.com, xiaolihuawj@sina.com.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Kang
authors.forename: Ya-Ping
authors.initials: YP
authors.lastname: Gao
authors.forename: Yan
authors.initials: Y
authors.lastname: Hei
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Xiao
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
mesh_terms: D000251:Adenosine Triphosphatases / Q000096:biosynthesis* / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018797:Cell Cycle Proteins / Q000096:biosynthesis* / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology; D011379:Prognosis; D015996:Survival Rate; D000074405:Valosin Containing Protein
chemical_list: D018797:Cell Cycle Proteins; D000251:Adenosine Triphosphatases; C000614178:VCP protein, human; D000074405:Valosin Containing Protein