title: Luminescent oligo(ethylene glycol)-functionalized cyclometalated platinum(II) complexes: cellular characterization and mitochondria-specific localization.
abstract: A readily tunable series of non-planar oligo(ethylene glycol)-substituted phosphorescent Pt(II) complexes has been investigated as live cell imaging agents; suitable structural modifications can give good cellular uptake, traceable mitochondria-specific localization and potent cytotoxic characteristics towards HeLa cells.
authors.affiliation: Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China. mcwchan@cityu.edu.hk.
authors.forename: Zhengqing
authors.initials: Z
authors.lastname: Guo
authors.forename: Wah-Leung
authors.initials: WL
authors.lastname: Tong
authors.forename: Michael C W
authors.initials: MC
authors.lastname: Chan
mesh_terms: D001692:Biological Transport; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D049408:Luminescent Agents / Q000737:chemistry* / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D057054:Molecular Imaging; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000378:metabolism*; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D049408:Luminescent Agents; D009944:Organoplatinum Compounds; D011092:Polyethylene Glycols