title: The immunoinhibitory B7-H1 molecule as a potential target in cancer: killing many birds with one stone.
abstract: Over expression of B7-H1 (also named PDL-1 or CD 274) molecule in cancer has been linked to worse prognosis and resistance to anti-cancer therapies in several malignancies. In this review, we update on the expression of B7-H1 molecule in solid and hematological malignancies. We also describe the possible mechanisms by which this molecule inhibits/downregulates the immune response to cancer cells. Finally, we highlight current and future potential therapeutic strategies that can be further developed to target this molecule.
authors.affiliation: Immunology and Innovative Cell Therapy Unit, Biomedical Research Facility, Research Center, King Fahad Specialist Hospital Dammam, PO Box 15215, 31444 Dammam, Saudi Arabia.
authors.forename: Sehar
authors.initials: S
authors.lastname: Afreen
authors.affiliation: Immunology and Innovative Cell Therapy Unit, Biomedical Research Facility, Research Center, King Fahad Specialist Hospital Dammam, PO Box 15215, 31444 Dammam, Saudi Arabia. Electronic address: said.dermime@kfsh.med.sa.
authors.forename: Said
authors.initials: S
authors.lastname: Dermime
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D060890:B7-H1 Antigen / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D007109:Immunity / Q000187:drug effects; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy*
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D060890:B7-H1 Antigen
keywords: B7-H1; CD 274; Cancer prognosis; Immune escape; PD-L1; Targeted therapy