title: Skin barrier in atopic dermatitis.
abstract: The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in particular atopic dermatitis (AD). This review summarizes current knowledge on the role of the skin barrier in AD with regard to pathogenesis and treatment, on the relationship between skin barrier abnormalities and immune aberrations, and on potential therapies aimed at repair of the skin barrier. Furthermore recent advances in the genetics of AD will be addressed.
authors.affiliation: Coronel Institute of Occupational Health, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
authors.forename: Sanja
authors.initials: S
authors.lastname: Kezic
authors.affiliation: Department of Dermatology and Allergy, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.
authors.forename: Natalija
authors.initials: N
authors.lastname: Novak
authors.affiliation: Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia.
authors.forename: Ivone
authors.initials: I
authors.lastname: Jakasa
authors.affiliation: Department of Dermatology, Roskilde Hospital, University of Copenhagen Køgevej 7-13, 4000 Roskilde, Denmark.
authors.forename: Jackob M
authors.initials: JM
authors.lastname: Jungersted
authors.affiliation: CNRS-INSERM-University of Toulouse, UMR5165, CHU Purpan, Place du Dr. Baylac, TSA40031, 31059, Toulouse, Cedex 9, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Simon
authors.affiliation: Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Brandner
authors.affiliation: Department of Dermatology, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.
authors.forename: Maritza A
authors.initials: MA
authors.lastname: Middelkamp-Hup
authors.affiliation: Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany.
authors.forename: Stephan
authors.initials: S
authors.lastname: Weidinger
mesh_terms: D003876:Dermatitis, Atopic / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008055:Lipids / Q000502:physiology; D012869:Skin Absorption; D019108:Tight Junctions / Q000378:metabolism
chemical_list: D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D008055:Lipids