title: Chimeric anti-IL-17 full-length monoclonal antibody is a novel potential candidate for the treatment of rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is an autoimmune disease, primarily manifesting as inflammatory arthritis. It is associated with chronic inflammation of the synovial joints, mostly in the hands and feet, as well as with systemic extra-articular inflammation. The chimeric anti-interleukin (IL)-17 full-length monoclonal antibody (CMa17Aab) targets IL-17A, which is an important cytokine in the pathogenesis of RA and other inflammatory disorders. In this study, we investigated whether CMa17Aab exerts therapeutic effects in a mouse model of type II collagen-induced arthritis (CIA). Mice with CIA were subcutaneously injected with the humanized CMa17Aab antibody. The effects of treatment were assessed by estimating the arthritis severity score, the extent of histological damage and bone destruction, the autoreactive humoral and cellular immune responses and the production of cytokines. Treatment with CMa17Aab exerted beneficial effects in the mice with CIA as regards clinical and histological parameters. Compared with the controls, treatment with CMa17Aab resulted in a significant alleviation of the severity of the symptoms of arthritis, by preventing bone damage and cartilage destruction, reducing humoral and cellular immune responses, and downregulating the expression of IL-6, IL-8, matrix metalloproteinase (MMP)-3, IL-17, IL-1β, tumor necrosis factor (TNF)-α, receptor activator for nuclear factor-κB ligand (RANKL) and interferon (IFN)-γ in inflamed tissues. In conclusion, our study demonstrates that treatment with CMa17Aab exerts beneficial effects in mice with CIA, by preventing joint inflammation, cartilage destruction and bone damage. These preliminary results suggest that CMa17Aab is an important regulator in RA, and that it may represent a novel therapeutic agent that may prove useful in the treatment of this disease.
authors.affiliation: Biopharmaceutical Teaching and Research Section, College of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.
authors.forename: Fuliang
authors.initials: F
authors.lastname: Bai
authors.affiliation: Biopharmaceutical Teaching and Research Section, College of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.
authors.forename: Hui
authors.initials: H
authors.lastname: Tian
authors.affiliation: Biopharmaceutical Teaching and Research Section, College of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.
authors.forename: Zeshan
authors.initials: Z
authors.lastname: Niu
authors.affiliation: Biopharmaceutical Teaching and Research Section, College of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.
authors.forename: Mingyao
authors.initials: M
authors.lastname: Liu
authors.affiliation: Biopharmaceutical Teaching and Research Section, College of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.
authors.forename: Guiping
authors.initials: G
authors.lastname: Ren
authors.affiliation: Biopharmaceutical Teaching and Research Section, College of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.
authors.forename: Yinhang
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Biopharmaceutical Teaching and Research Section, College of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.
authors.forename: Tian
authors.initials: T
authors.lastname: Sun
authors.affiliation: Biopharmaceutical Teaching and Research Section, College of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.
authors.forename: Siming
authors.initials: S
authors.lastname: Li
authors.affiliation: Biopharmaceutical Teaching and Research Section, College of Life Science, Northeast Agricultural University, Harbin, Heilongjiang 150030, P.R. China.
authors.forename: Deshan
authors.initials: D
authors.lastname: Li
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D001169:Arthritis, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000628:therapy*; D002356:Cartilage / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D020381:Interleukin-17 / Q000037:antagonists & inhibitors / Q000276:immunology*; D007596:Joints / Q000276:immunology / Q000473:pathology; D051379:Mice; D011993:Recombinant Fusion Proteins / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D020381:Interleukin-17; D011993:Recombinant Fusion Proteins