title: Iodine-catalyzed 1,3-dipolar cycloaddition/oxidation/aromatization cascade with hydrogen peroxide as the terminal oxidant: general route to pyrrolo[2,1-a]isoquinolines.
abstract: We report a novel molecular iodine-catalyzed 1,3-dipolar cycloaddition/oxidation/aromatization cascade process with hydrogen peroxide as the terminal oxidant for the construction of pyrrolo[2,1-a]isoquinolines. The product pyrrolo[2,1-a]isoquinolines were obtained from reactions between simple, readily available dipolarophiles and tetrahydroisoquinolines in moderate to excellent yields without the need for a metal catalyst.
authors.affiliation: State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Zhejiang University of Technology , Hangzhou 310014, People's Republic of China.
authors.forename: Huan-Ming
authors.initials: HM
authors.lastname: Huang
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.forename: Wu-Bin
authors.initials: WB
authors.lastname: Yu
authors.forename: Liang
authors.initials: L
authors.lastname: Han
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Jia
authors.forename: Jian-Rong
authors.initials: JR
authors.lastname: Gao