title: Percutaneous image-guided cryoablation in inoperable extra-abdominal desmoid tumors: a study of tolerability and efficacy.
abstract: OBJECTIVE
  To determine the tolerability, effectiveness and outcomes of percutaneous image-guided cryoablation on inoperable extra-abdominal desmoid tumors.
  
  
  METHODS
  Between 2011 and 2012, 13 patients (mean age 39.3 years, range 15-74) with inoperable extra-abdominal desmoid tumors were consecutively treated with cryoablation (17 tumors treated in 17 procedures), including two patients with Gardner syndrome and nine recurrences after surgery. Disease-free survival (DFS) and local control based on RECIST criteria were calculated on prospective clinical and imaging follow-up until 2013.
  
  
  RESULTS
  Cryoablation was performed under ultrasound (n = 8), computed tomography (n = 1), or combined (n = 8) guidance, and under general (n = 15) or local (n = 2) anesthesia. A major complication was observed in one session (5.8%). Mean follow-up was 11.3 months (6-27 months). Among all the patients treated, eight patients (47%) presented residual tumors on the first magnetic resonance follow-up, which were asymptomatic. The DFS rate was stable at 82.3% (95% confidence interval 0.55-0.94) at 6, 12, and 24 months. The local tumor progression rate was 0% at 6, 12, and 24 months. Two patients (12%) presented an in situ recurrence.
  
  
  CONCLUSIONS
  Despite high rates of partial ablation, percutaneous image-guided cryoablation appears to be safe and effective for local control for patients with inoperable extra-abdominal desmoid tumors.
authors.affiliation: Department of Radiology, Hôpital Pellegrin, CHU de Bordeaux, Place Amélie Raba Léon, 33076, Bordeaux, France.
authors.forename: M
authors.initials: M
authors.lastname: Havez
authors.forename: N
authors.initials: N
authors.lastname: Lippa
authors.forename: S
authors.initials: S
authors.lastname: Al-Ammari
authors.forename: M
authors.initials: M
authors.lastname: Kind
authors.forename: E
authors.initials: E
authors.lastname: Stoeckle
authors.forename: A
authors.initials: A
authors.lastname: Italiano
authors.forename: A
authors.initials: A
authors.lastname: Gangi
authors.forename: O
authors.initials: O
authors.lastname: Hauger
authors.forename: F
authors.initials: F
authors.lastname: Cornelis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003452:Cryosurgery / Q000379:methods*; D005260:Female; D018221:Fibromatosis, Abdominal / Q000601:surgery*; D005736:Gardner Syndrome / Q000601:surgery*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015641:Radiography, Interventional; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional