title: [A Meta-analysis of efficacy and safety of sublingual immunotherapy on allergic asthma].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of sublingual immunotherapy(SLIT) in patients with allergic asthma in order to provide reliable evidence for clinical application of SLIT.
  
  
  METHODS
  To search published articles of randomized controlled trials (RCTs) in allergic asthma from CNKI, WANFANG, Pubmed and Medline databases. The methodological quality of trials was assessed by Jadad-scale. The heterogeneity was examined by using Stata 11.0 software. Fixed effect model or random effect model was used to pool the data. The articles which could not be pooled were carried out by descriptive analysis. The Egger's and Begg's test were used to evaluate the publication bias.
  
  
  RESULTS
  There were total 6 RCTs included in this text. Compared with control group, SLIT could significantly reduce asthma symptom scores (SMD = -0.89, 95%CI -1.36--0.43, P = 0.000) and asthma medication scores (SMD = -4.53, 95%CI -6.97--2.08, P = 0.000), but not forced expiratory volume (FEV1) of lung function(SMD = 0.19, 95%CI -0.02-0.41, P = 0.078), neither serum sIgE levels (SMD = 0.05, 95%CI -0.58-0.69, P = 0.870). There were no obvious adverse events reported after treatment of SLIT. No publication bias were indicated by Egger's and Begg's tests.
  
  
  CONCLUSIONS
  SLIT significantly reduces asthma symptom scores and medication scores, suggesting that SLIT is a safe and effective approach of immunotherapy. However, it still needs more highly qualified studies of RCTs to prove.
authors.affiliation: Respiratory Department, Institute of Respiratory Disease, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Wu
authors.affiliation: Respiratory Department, Institute of Respiratory Disease, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Xin-ming
authors.initials: XM
authors.lastname: Xie
authors.affiliation: Respiratory Department, Institute of Respiratory Disease, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Han
authors.affiliation: Respiratory Department, Institute of Respiratory Disease, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Shao-jun
authors.initials: SJ
authors.lastname: Li
authors.affiliation: Respiratory Department, Institute of Respiratory Disease, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.affiliation: Respiratory Department, Institute of Respiratory Disease, the Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an 710004, China. Email: manxiangli@hotmail.com.
authors.forename: Man-xiang
authors.initials: MX
authors.lastname: Li
mesh_terms: D001249:Asthma / Q000628:therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D063729:Sublingual Immunotherapy / Q000009:adverse effects* / Q000379:methods*