title: Predictors of reperfusion delay in patients with ST elevation myocardial infarction self-transported to the hospital (from the American Heart Association's Mission: Lifeline Program).
abstract: Primary percutaneous coronary intervention for ST elevation myocardial infarction (STEMI) is beneficial if performed in a timely manner. Self-transport patients with STEMI have prolonged treatment times compared with Emergency Medical Services-transported patients. This study evaluated self-transport patients with STEMI undergoing primary percutaneous coronary intervention to identify factors associated with prolonged door-to-balloon (D2B) times. From January 2007 to March 2011, data for 13,379 self-transport patients with STEMI treated at 432 hospitals in the Acute Coronary Treatment Intervention Outcomes Network Registry-Get With The Guidelines Registry were evaluated. Patients with a D2B time >90 minutes were compared with those with D2B time ≤90 minutes. Factors associated with prolonged D2B (>90 minutes) were explored using logistic generalized estimating equations. The median (twenty-fifth, seventy-fifth percentiles) D2B time for the entire cohort was 72 minutes (58, 86), and 19% had a D2B time of >90 minutes. Over the study period, there was a significant increase in the percentage of patients achieving D2B time ≤90 minutes. There were significant baseline differences between patients with D2B time ≤ versus >90 minutes. The main factors associated with prolonged treatment time were off-hour presentation (weekends and 7 p.m. to 7 a.m. weekdays), not obtaining an electrocardiogram within 10 minutes of hospital arrival, previous coronary artery bypass surgery, black race, older age, and female gender. In conclusion, although prolonged delay from arrival to electrocardiographic acquisition is a modifiable factor contributing to prolonged D2B times among self-transport patients with STEMI, additional factors (age, race, and gender) indicate that historic disparities for cardiovascular care still persist in terms of contemporary metrics for STEMI reperfusion.
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California. Electronic address: shavelle@usc.edu.
authors.forename: David M
authors.initials: DM
authors.lastname: Shavelle
authors.affiliation: Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
authors.forename: Anita Y
authors.initials: AY
authors.lastname: Chen
authors.affiliation: Division of Cardiovascular Medicine, University of Southern California, Los Angeles, California.
authors.forename: Ray V
authors.initials: RV
authors.lastname: Matthews
authors.affiliation: Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Roe
authors.affiliation: Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas.
authors.forename: James A
authors.initials: JA
authors.lastname: de Lemos
authors.affiliation: Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
authors.forename: James
authors.initials: J
authors.lastname: Jollis
authors.affiliation: Division of Cardiology, Harbor UCLA Medical Center, Torrance, California.
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Thomas
authors.affiliation: Division of Cardiology, Harbor UCLA Medical Center, Torrance, California.
authors.forename: William J
authors.initials: WJ
authors.lastname: French
mesh_terms: D039602:After-Hours Care; D000368:Aged; D004632:Emergency Medical Services; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D015425:Myocardial Reperfusion / Q000592:standards*; D062645:Percutaneous Coronary Intervention / Q000592:standards*; D017064:Process Assessment, Health Care; D012307:Risk Factors; D013997:Time Factors; D061665:Time-to-Treatment / Q000592:standards; D014187:Transportation of Patients