title: MUTYH association with esophageal adenocarcinoma in a Han Chinese population.
abstract: Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic and environmental factors. Much evidence has shown that the MutY glycosylase homologue (MUTYH) plays a key role in the pathogenesis of many cancers. However, there have been no reports on influence on AE in the Han Chinese population. The objective of this study was to investigate this issue. A gene-based association study was conducted using three single nucleotide polymorphisms(SNPs) reported in previous studies. The three SNPs (rs3219463, rs3219472, rs3219489) were genotyped in 207 unrelated AE patients and 249 healthy controls in a case-control study using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). The results revealed that the genotype distribution of rs3219472 differed between the case and control groups (OR=1.66,95%CI=1.11-2.48, P=0.012 ), indicating that an association may exist between MUTYH and AE. These findings support a signifcant role for MUTYH in AE pathogenesis in the Han Chinese population.
authors.affiliation: Central Research Laboratory, The Second Hospital of Shandong University, Jinan, China E-mail : chenggh2008@aliyun. com, jingjiezhao@aliyun.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Kong
authors.forename: Xue-Ying
authors.initials: XY
authors.lastname: Han
authors.forename: Yun
authors.initials: Y
authors.lastname: Luan
authors.forename: Tong-Gang
authors.initials: TG
authors.lastname: Qi
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Hua-Ying
authors.initials: HY
authors.lastname: Hou
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Jiang
authors.forename: Jing-Jie
authors.initials: JJ
authors.lastname: Zhao
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Cheng
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D045647:DNA Glycosylases / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D045647:DNA Glycosylases; C061738:mutY adenine glycosylase