title: Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastoma.
abstract: While a polymorphism located within the promoter region of the MDM2 proto-oncogene, SNP309 (T > G), has previously been associated with increased risk and aggressiveness of neuroblastoma and other tumor entities, a protective effect has also been reported in certain other cancers. In this study, we evaluated the association of MDM2 SNP309 with outcome in 496 patients with neuroblastoma and its effect on MDM2 expression. No significant difference in overall or event-free survival was observed among patients with neuroblastoma with or without MDM2 SNP309. The presence of SNP309 does not affect MDM2 expression in neuroblastoma.
authors.affiliation: Center for Medical Genetics, Ghent University, Ghent, Belgium.
authors.forename: Ali
authors.initials: A
authors.lastname: Rihani
authors.forename: Tom
authors.initials: T
authors.lastname: Van Maerken
authors.forename: Bram
authors.initials: B
authors.lastname: De Wilde
authors.forename: Fjoralba
authors.initials: F
authors.lastname: Zeka
authors.forename: Geneviève
authors.initials: G
authors.lastname: Laureys
authors.forename: Koen
authors.initials: K
authors.lastname: Norga
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Tonini
authors.forename: Simona
authors.initials: S
authors.lastname: Coco
authors.forename: Rogier
authors.initials: R
authors.lastname: Versteeg
authors.forename: Rosa
authors.initials: R
authors.lastname: Noguera
authors.forename: Johannes H
authors.initials: JH
authors.lastname: Schulte
authors.forename: Angelika
authors.initials: A
authors.lastname: Eggert
authors.forename: Raymond L
authors.initials: RL
authors.lastname: Stallings
authors.forename: Frank
authors.initials: F
authors.lastname: Speleman
authors.forename: Jo
authors.initials: J
authors.lastname: Vandesompele
mesh_terms: D018572:Disease-Free Survival; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D009447:Neuroblastoma / Q000235:genetics* / Q000401:mortality*; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics; D000090063:Proto-Oncogene Mas; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2
keywords: MDM2 SNP309; genotyping; neuroblastoma; survival