title: Mitochondrial cardiolipin/phospholipid trafficking: the role of membrane contact site complexes and lipid transfer proteins.
abstract: Historically, cellular trafficking of lipids has received much less attention than protein trafficking, mostly because its biological importance was underestimated, involved sorting and translocation mechanisms were not known, and analytical tools were limiting. This has changed during the last decade, and we discuss here some progress made in respect to mitochondria and the trafficking of phospholipids, in particular cardiolipin. Different membrane contact site or junction complexes and putative lipid transfer proteins for intra- and intermembrane lipid translocation have been described, involving mitochondrial inner and outer membrane, and the adjacent membranes of the endoplasmic reticulum. An image emerges how cardiolipin precursors, remodeling intermediates, mature cardiolipin and its oxidation products could migrate between membranes, and how this trafficking is involved in cardiolipin biosynthesis and cell signaling events. Particular emphasis in this review is given to mitochondrial nucleoside diphosphate kinase D and mitochondrial creatine kinases, which emerge to have roles in both, membrane junction formation and lipid transfer.
authors.affiliation: Univ. Grenoble-Alpes, Laboratory of Fundamental and Applied Bioenergetics (LBFA) and SFR Environmental and Systems Biology (BEeSy), Grenoble, France; Inserm, U1055, Grenoble, France. Electronic address: uwe.schlattner@ujf-grenoble.fr.
authors.forename: Uwe
authors.initials: U
authors.lastname: Schlattner
authors.affiliation: Univ. Grenoble-Alpes, Laboratory of Fundamental and Applied Bioenergetics (LBFA) and SFR Environmental and Systems Biology (BEeSy), Grenoble, France; Inserm, U1055, Grenoble, France.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Tokarska-Schlattner
authors.affiliation: Univ. Grenoble-Alpes, Laboratory of Fundamental and Applied Bioenergetics (LBFA) and SFR Environmental and Systems Biology (BEeSy), Grenoble, France; Inserm, U1055, Grenoble, France.
authors.forename: Denis
authors.initials: D
authors.lastname: Rousseau
authors.affiliation: UPMC Université Paris 06, Paris, France; Inserm, UMRS938, Paris, France; Hôpital Tenon, AP-HP, Service de Biochimie et Hormonologie, Paris, France.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Boissan
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: Carmen
authors.initials: C
authors.lastname: Mannella
authors.affiliation: Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Richard
authors.initials: R
authors.lastname: Epand
authors.affiliation: UPMC Université Paris 06, Paris, France; Inserm, UMRS938, Paris, France.
authors.forename: Marie-Lise
authors.initials: ML
authors.lastname: Lacombe
mesh_terms: D001692:Biological Transport; D002308:Cardiolipins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D051336:Mitochondrial Membranes / Q000378:metabolism
chemical_list: D002308:Cardiolipins; D002352:Carrier Proteins; C030363:lipid transfer protein
keywords: Cardiolipin; Creatine kinase; Endoplasmic reticulum; Lipid Transport; Lipid trafficking; Lipid transfer proteins; Membrane contact sites; Membrane junction complexes; Mitochondria; Nm23; Nucleoside diphosphate kinase.