title: [Study of adiponectin, IL-1β, IL-6 and TNF-α in first episode drug naїve schizophrenia].
abstract: OBJECTIVE
  To explore the levels of adiponectin (APN), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in first episode drug naїve schizophrenics and further examine the role of adipocytokines in schizophrenia.
  
  
  METHODS
  Ninety-six normal weight schizophrenics and 22 overweight/obese ones from First Affiliated Hospital, Zhengzhou University and 60 healthy controls were enrolled. Serum levels of IL-1β, IL-6, TNF-α and APN were measured with enzyme linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Serum levels of IL-1β, IL-6 and TNF-α in normal weight schizophrenics (54 ± 13, 34 ± 12, 48 ± 18) pg/ml and overweight/obese schizophrenics (71 ± 21, 40 ± 12, 53 ± 18) pg/ml were significantly higher than those in the controls (23 ± 16, 16 ± 7, 32 ± 15) pg/ml (P < 0.05). Serum levels of IL-1β and IL-6 in overweight/obese schizophrenics were significantly higher than those in normal weight schizophrenics (P < 0.05). Serum level of adiponectin in normal weight schizophrenics was significantly higher than that in control group [(12 ± 4) vs (9 ± 4) pg/ml, P < 0.05].
  
  
  CONCLUSIONS
  The serum levels of APN, IL-1β, IL-6 and TNF-α increase in first episode drug naїve schizophrenics. It suggests that an inflammatory response mediated by adipocytokines. APN may play a pro-inflammatory role in schizophrenia.
authors.affiliation: Department of Psychiatry, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. Email: sxqzhll@126.com.
authors.forename: Xue-qin
authors.initials: XQ
authors.lastname: Song
authors.forename: Xu-mei
authors.initials: XM
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Xue
authors.initials: X
authors.lastname: Li
authors.forename: Gang-rui
authors.initials: GR
authors.lastname: Hei
authors.forename: You-hui
authors.initials: YH
authors.lastname: Li
authors.forename: Yi-hui
authors.initials: YH
authors.lastname: Hao
authors.affiliation: Department of Psychiatry, Second Affiliated Hospital, Xinxiang Medical University, Xinxiang 453002, China. Email: lvluxian@126.com.
authors.forename: Lu-xian
authors.initials: LX
authors.lastname: Lü
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D012559:Schizophrenia / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D055815:Young Adult
chemical_list: D052242:Adiponectin; C508585:IL1B protein, human; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha