title: Single amino acid chelate complexes of the M(CO)3 (+) core for correlating fluorescence and radioimaging studies (M = (99m) Tc or Re).
abstract: Single amino acid chelates (SAACs) and SAAC-like bifunctional ligands can be exploited in the design of a variety of bioconjugates for facile metallation with the M(CO)3 (+) unit with M = (99m) Tc or Re. When the donor groups of the ligand are quinolone, thiazole or other similarly conjugated heterocycles, the rhenium complexes are fluorescent, affording complementary and isostructural fluorescent probes to the radioactive (99m) Tc analogues. The versatility of the approach has been demonstrated by the preparation of bioconjugates incorporating peptides, biotin, folic acid, thymidine and vitamin B12 . In addition, the unusual photophysical properties observed for rhenium of the [bisthiazole-diamino butane-Re(CO)3 (+) ] derivative [BTBA-Re(CO)3 ](+) are discussed.
authors.affiliation: School of Chemistry and Chemical Biology, University of Lancaster, Lancaster, LA1 4YB, UK.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Coogan
authors.forename: Robert P
authors.initials: RP
authors.lastname: Doyle
authors.forename: John F
authors.initials: JF
authors.lastname: Valliant
authors.forename: John W
authors.initials: JW
authors.lastname: Babich
authors.forename: Jon
authors.initials: J
authors.lastname: Zubieta
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D002614:Chelating Agents / Q000737:chemistry*; D006801:Humans; D061848:Optical Imaging / Q000379:methods*; D011877:Radionuclide Imaging / Q000379:methods*; D012211:Rhenium / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D002614:Chelating Agents; D012211:Rhenium; D013667:Technetium
keywords: bioconjugate chemistry; correlation of in vitro fluorescence and in vivo radioimaging; fluorescence spectroscopy; rhenium photophysics; rhenium-tricarbonyl core