title: Multicentric Castleman's disease and HIV.
abstract: Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder found with a higher frequency in HIV-seropositive patients. Human herpes virus 8 is found in virtually all cases of HIV-associated MCD. The majority of cases of MCD in patients with HIV are also associated with Kaposi's sarcoma. The dysregulated production of human IL-6 is thought to be an important factor in the pathogenesis of MCD. HIV-seropositive individuals with MCD have a significantly greater risk of developing non-Hodgkin lymphomas than their HIV-seronegative counterparts. MCD occurring in HIV patients has been associated with a poor prognosis. With newer therapy regimens, it is hoped that the prospects of HIV-infected patients with MCD will improve.
authors.affiliation: Department of Pathology, Section of Hematopathology (Krause), and the Department of Hematology/Oncology (Robinson, Vance), Baylor University Medical Center at Dallas and the Baylor Charles A. Sammons Cancer Center at Dallas.
authors.forename: John R
authors.initials: JR
authors.lastname: Krause
authors.affiliation: Department of Pathology, Section of Hematopathology (Krause), and the Department of Hematology/Oncology (Robinson, Vance), Baylor University Medical Center at Dallas and the Baylor Charles A. Sammons Cancer Center at Dallas.
authors.forename: Sara D
authors.initials: SD
authors.lastname: Robinson
authors.affiliation: Department of Pathology, Section of Hematopathology (Krause), and the Department of Hematology/Oncology (Robinson, Vance), Baylor University Medical Center at Dallas and the Baylor Charles A. Sammons Cancer Center at Dallas.
authors.forename: Estil A
authors.initials: EA
authors.lastname: Vance