title: Herpes simplex hepatitis after liver transplantation: case report and literature review.
abstract: Herpes simplex virus (HSV) hepatitis is an uncommon cause of liver failure, but may have a dramatic outcome. We herein present a case report of a liver graft infection by HSV-1 associated with liver failure and encephalitis. A complete hospital chart review of the case and a literature search were undertaken. Literature review suggests that herpes simplex acute liver failure is rare and associated with a poor prognosis, even with early treatment. Novel diagnostic and preventive approaches need to be instituted.
authors.affiliation: Hepatology Service, Department of Medicine, Saint-Luc Hospital, CHUM, University of Montreal, Montreal, Quebec, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Côté-Daigneault
authors.forename: F M
authors.initials: FM
authors.lastname: Carrier
authors.forename: K
authors.initials: K
authors.lastname: Toledano
authors.forename: C
authors.initials: C
authors.lastname: Wartelle-Bladu
authors.forename: B
authors.initials: B
authors.lastname: Willems
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D020803:Encephalitis, Herpes Simplex / Q000188:drug therapy / Q000635:transmission*; D017809:Fatal Outcome; D006525:Hepatitis, Viral, Human / Q000188:drug therapy / Q000209:etiology / Q000635:transmission*; D006561:Herpes Simplex / Q000188:drug therapy / Q000635:transmission*; D018259:Herpesvirus 1, Human; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D019737:Transplants / Q000821:virology*
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir
keywords: acute liver failure; hepatitis; herpes simplex; liver transplant