title: [Pathological complete response in 2 patients with cT4 esophageal cancer treated with neoadjuvant chemoradiation therapy].
abstract: We report the cases of 2 patients with clinical T4( cT4) esophageal cancer who achieved pathological complete response on treatment with neoadjuvant chemoradiation therapy. Case 1 involved a 68-year-old woman who was diagnosed as having cT4 advanced esophageal cancer( with involvement of the aorta and left pulmonary vein). Neoadjuvant chemoradiation therapy with 5-fluorouraci(l 5-FU)( 800 mg/m2, days 1-5 and days 29-33), cisplatin( CDDP 80 mg/m2, days 1 and 29), and radiation (39.6 Gy/22 Fr) was administered, and the tumor showed a partial response (PR). Case 2 involved a 69-year-old man who was diagnosed as having cT4 advanced esophageal cancer( with involvement of the main bronchus). Neoadjuvant chemoradiation therapy with 5-FU( 800 mg/m2, days 1-5 and days 29-33), CDDP( 80 mg/m2, days 1 and 29), and radiation( 39.6 Gy/22 Fr) was administered, and the tumor showed a clinical PR. After tumor response was noted, curative esophagectomy was performed in both cases, without any complications, and a pathological complete response was achieved in both patients.
authors.affiliation: Dept. of Surgery, Yokosuka Kyosai Hospital.
authors.forename: Ryo
authors.initials: R
authors.lastname: Takagawa
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Mogaki
authors.forename: Chiho
authors.initials: C
authors.lastname: Endo
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kubo
authors.forename: Gakuryu
authors.initials: G
authors.lastname: Nakayama
authors.forename: Akinori
authors.initials: A
authors.lastname: Goto
authors.forename: Yuki
authors.initials: Y
authors.lastname: Homma
authors.forename: Yuta
authors.initials: Y
authors.lastname: Minami
authors.forename: Jun
authors.initials: J
authors.lastname: Watanabe
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Morita
authors.forename: Hidenobu
authors.initials: H
authors.lastname: Masui
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D059248:Chemoradiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000473:pathology / Q000628:therapy*; D016629:Esophagectomy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil