title: The trifluoromethylating Sandmeyer reaction: a method for transforming C-N into C-CF(3).
abstract: A means to trifluoromethylate: The beneficial properties imparted by the trifluoromethylation of aromatic compounds continue to drive the discovery of novel reagents and reactions for the late-stage introduction of such moieties. Highlighted here is the recently discovered Sandmeyer trifluoromethylation approach, which now permits aromatic amines to be substrates in a direct trifluoromethylation strategy.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK). db543@cam.ac.uk.
authors.forename: Duncan L
authors.initials: DL
authors.lastname: Browne
keywords: arenes; copper; fluorine; reaction mechanisms; synthetic methods