title: [Epidemiological and etiological characteristics of diarrheal disease among children under 5 years of age in Guangdong province, in 2012].
abstract: OBJECTIVE
  To analyze the epidemiological and etiological characteristics of diarrheal disease among children under 5 years of age in Guangdong province, in 2012.
  
  
  METHODS
  64 hospitals in 21 cities were chosen as the diarrheal syndromic surveillance sites, of which 14 hospitals were selected to carry out etiological surveillance among children under 5 years of age, including isolation and culture of both Vibrio cholera and Shigella as well as nucleic acid detection of rotavirus and norovirus by PCR. Descriptive method was used to analyze data from syndromic and etiological surveillance programs on diarrheal, from 1932 parents of the children.
  
  
  RESULTS
  In 2012, the outpatient attendance rate on diarrheal among children under 5 years was 0.8%. The proportion of diarrheal in children under 5-year-olds was 63.5%, among the total number of diarrheal outpatients at the outpatient clinics under surveillance program. The morbidity of infectious diarrhea was 1454.5/10 million in children under 5 years of age. A total number of 1932 specimens were collected from children under 5 years of age, in the outpatient department. Among these specimens,Vibrio cholera appeared all negative but one was Shigella positive and proved to be Sh. sonnei. The positive rates of rotavirus and norovirus were 14.1% (273/1932)and 16.9% (326/1932). Both rotavirus and norovirus were found in 24 specimens, with a positive rate as 1.2% . 112 specimens were successfully gene sequenced for rotavirus, of which 33.9% as G1[P8] genotype, 25.9% as G9[P8], 12.5% as G2[P4] and 9.8% as G3[P8] respectively. 90 specimens were successfully gene-sequenced for norovirus, of which 76.7% as G II.4 genotype. Genetic subtypes of G II. 4/2006b, accounted for 50.0% and could be detected around the year except for June and December. New G II. 4/Sydney Strain_2012 was first detected in August and became the predominant in December. In addition, 5 specimens belonged to G I genotype with other 16 subtypes of G II.
  
  
  CONCLUSIONS
  Results from our study proved that children under 5 years of age belonged to high-risk group for diarrheal disease in Guangdong province. Rotavirus and norovirus were both diverse in terms of genome.
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
authors.forename: Li-mei
authors.initials: LM
authors.lastname: Sun
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
authors.forename: Xiao-hua
authors.initials: XH
authors.lastname: Tan
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Fang
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
authors.forename: Ai-ping
authors.initials: AP
authors.lastname: Deng
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
authors.forename: Yan-ling
authors.initials: YL
authors.lastname: Mo
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: He
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China.
authors.forename: Chang-wen
authors.initials: CW
authors.lastname: Ke
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. Email: linjy1957@sohu.com.
authors.forename: Jin-yan
authors.initials: JY
authors.lastname: Lin
mesh_terms: D017250:Caliciviridae Infections / Q000453:epidemiology; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology* / Q000821:virology; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D012400:Rotavirus Infections / Q000453:epidemiology