title: Design, development of water tank-type lung phantom and dosimetric verification in institutions participating in a phase I study of stereotactic body radiation therapy in patients with T2N0M0 non-small cell lung cancer: Japan Clinical Oncology Group trial (JCOG0702).
abstract: A domestic multicenter phase I study of stereotactic body radiotherapy (SBRT) for T2N0M0 non-small cell lung cancer in inoperable patients or elderly patients who refused surgery was initiated as the Japan Clinical Oncology Group trial (JCOG0702) in Japan. Prior to the clinical study, the accuracy of dose calculation in radiation treatment-planning systems was surveyed in participating institutions, and differences in the irradiating dose between the institutions were investigated. We developed a water tank-type lung phantom appropriate for verification of the exposure dose in lung SBRT. Using this water tank-type lung phantom, the dose calculated in the radiation treatment-planning system and the measured dose using a free air ionization chamber and dosimetric film were compared in a visiting survey of the seven institutions participating in the clinical study. In all participating institutions, differences between the calculated and the measured dose in the irradiation plan were as follows: the accuracy of the absolute dose in the center of the simulated tumor measured using a free air ionization chamber was within 2%, the mean gamma value was ≤ 0.47 on gamma analysis following the local dose criteria, and the pass rate was >87% for 3%/3 mm from measurement of dose distribution with dosimetric film. These findings confirmed the accuracy of delivery doses in the institutions participating in the clinical study, so that a study with integration of the institutions could be initiated.
authors.affiliation: Particle Therapy Division, Research Center for Innovative Oncology, National Cancer Center, 6-5-1, Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.
authors.forename: Teiji
authors.initials: T
authors.lastname: Nishio
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirato
authors.forename: Masayori
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Yuki
authors.initials: Y
authors.lastname: Miyabe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kito
authors.forename: Yuichirou
authors.initials: Y
authors.lastname: Narita
authors.forename: Rikiya
authors.initials: R
authors.lastname: Onimaru
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishikura
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiraoka
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007564:Japan; D008175:Lung Neoplasms / Q000532:radiotherapy*; D019047:Phantoms, Imaging / Q000592:standards*; D011874:Radiometry / Q000295:instrumentation* / Q000592:standards*; D016634:Radiosurgery / Q000592:standards*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014867:Water
chemical_list: D014867:Water
keywords: JCOG0702; lung SBRT clinical trial; visiting dose verification; water tank-type lung phantom