title: Giant drug-induced QT prolongation > 800 ms with alternans of terminal portion of T wave and J wave in a normothermic patient.
abstract: We describe a case of an 85-year-old woman admitted to hospital because of syncope with palpitations. The patient had mistakenly taken sotalol 120 mg/d together with carvedilol 6.25 mg/d. On hospital admission, ECG showed sinus bradycardia 52 bpm with marked QT prolongation: QTc presented variability from beat to beat (840 ms - 640 ms - 820 ms - 640 ms, respectively) with associated macro-alternans of T wave. T wave alternans was observed within the ascending portion of negative T wave. Beside it a J wave was seen.
authors.affiliation: Department of Internal Disease and Cardiology, Specialistic Hospital, Gorlice, Poland. kukla_piotr@poczta.onet.pl.
authors.forename: Piotr
authors.initials: P
authors.lastname: Kukla
authors.forename: Adrian
authors.initials: A
authors.lastname: Baranchuk
authors.forename: Marek
authors.initials: M
authors.lastname: Jastrzębski
authors.forename: Leszek
authors.initials: L
authors.lastname: Bryniarski
authors.forename: Rafał
authors.initials: R
authors.lastname: Baranowski
mesh_terms: D000369:Aged, 80 and over; D004562:Electrocardiography; D005260:Female; D005936:Glucans; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D005936:Glucans; C439358:alternan