title: [Proteolysis of simple glyprolines by leucine aminopeptidase and enzymes from nasal slime, brain membranes, and rat blood].
abstract: Proteolysis of Pro-Gly-Pro-Leu, Pro-Gly-Pro-Gly and Pro-Gly-Pro were studied comparatively to Met-Glu-His-Phe-Pro-Gly-Pro (semax). It is shown that all three peptides are considerably more stable to proteolysis by N-leucine-aminopeptidase (EC 3.4.11.1, Sigma, type VI, 9.2 units/mg), and by enzymes of nasal slime, brain microsomal fractions, and rat blood. Metabolites of the proteolysis showed that semax derives His-Phe-Pro-Gly-Pro only, Pro-Gly-Pro-Leu forms Gly-Pro-Leu, Pro-Gly-Pro and Gly-Pro, Pro-Gly-Pro-Gly gives Pro-Gly-Pro and Gly-Pro, and Pro-Gly-Pro forms Gly-Pro.
authors.forename: K V
authors.initials: KV
authors.lastname: Shevchenko
authors.forename: T V
authors.initials: TV
authors.lastname: V'iunova
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Nagaev
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: N F
authors.initials: NF
authors.lastname: Miasoedov
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D004798:Enzymes / Q000097:blood; D005998:Glycine / Q000737:chemistry*; D007931:Leucyl Aminopeptidase / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D059748:Proteolysis; D051381:Rats
chemical_list: D004798:Enzymes; D010455:Peptides; D011392:Proline; D007931:Leucyl Aminopeptidase; D005998:Glycine