title: Neuro-pharmacological potentials of Buchholzia coriacea (Engl.) seeds in laboratory rodents.
abstract: BACKGROUND
  Buchholzia coriacea, taken by elderly, has phytochemicals that have neuro-active metabolites, and the folklore documented its use in neuro-behavioural despairs.
  
  
  OBJECTIVE
  This study was conducted to investigate the neuro-pharmacological potentials of Buchholzia coriacea (MEBC) seed extract in the laboratory rodents.
  
  
  METHODS
  Methanol extract of the seeds on B. coriacea (MEBC) was evaluated for its antidepressant (Forced Swimming Test and Tail Suspension Test), anxiolytic (Light-Dark Test, Hole Board Test and Elevated Plus Maze), antinociceptive (Hot-Plate and Tail Flick test) and motor coordination (Rota Rod) functions in mice.
  
  
  RESULTS
  Our findings showed antidepressant activity (P < 0.05) of MEBC that is dose-dependent. Secondly, MEBC showed significant anxiolytic property that is comparable with the standard drug (diazepam). Furthermore, MEBC significantly prolonged the latency on hot-plate and tail flick responses when compared with the control (P < 0.05). Finally, MEBC significantly prolonged mice endurance time (P < 0.05) on a revolving Rota rod. The results suggest antidepressant, anxiolytic and analgesic potentials of MEBC.
  
  
  CONCLUSIONS
  Buchholzia coriacea may have a stabilizing effect on the motor activity and MEBC probably contains secondary metabolites with some therapeutic effects on neuro-physiological disorders like depression, anxiety and pain.
authors.affiliation: Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria. samphil2002@yahoo.com
authors.forename: S A
authors.initials: SA
authors.lastname: Onasanwo
authors.affiliation: Department of Physiology, College of Medicine, Osun State University, Oshogbo, Nigeria.
authors.forename: O O
authors.initials: OO
authors.lastname: Obembe
authors.affiliation: Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
authors.forename: S O
authors.initials: SO
authors.lastname: Faborode
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.
authors.forename: T O
authors.initials: TO
authors.lastname: Elufioye
authors.affiliation: Department of Biochemistry, College of Medicine, University of Lagos, Lagos, Nigeria.
authors.forename: R A
authors.initials: RA
authors.lastname: Adisa
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001007:Anxiety; D001522:Behavior, Animal / Q000187:drug effects*; D031483:Capparaceae; D003863:Depression; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D010146:Pain; D010936:Plant Extracts / Q000494:pharmacology*; D012639:Seeds
chemical_list: D000700:Analgesics; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010936:Plant Extracts