title: [Successful treatment of neuroendocrine ductal carcinoma in situ with loco-regional therapy].
abstract: Herein, we report the use of microdochectomy for neuroendocrine ductal carcinoma in situ( NE-DCIS). The patient was 44-year-old woman who experienced spontaneous nipple discharge for 5 years. We were unable to detect the origin of the nipple discharge by computed tomography (CT), magnetic resonance imaging (MRI), mammography, ductal endoscopy, or ultrasonography. Subsequently, endoscopy-assisted microdochectomy was performed under local anesthesia. Pathological examination of the resected specimen led to a diagnosis of NE-DCIS positive for estrogen and progesterone receptors and negative for HER2/neu protein expression. The Ki-67 positive cell index was 80%. The surgical margins were negative. After surgery, tamoxifen was administered. One year after the operation, the patient is well and metastases have not been noted. This case suggests that endoscopy-assisted microdochectomy under local anesthesia is useful for evaluating spontaneous nipple discharge.
authors.affiliation: Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakurai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Fujisaki
authors.forename: Tetsuyo
authors.initials: T
authors.lastname: Maeda
authors.forename: Saki
authors.initials: S
authors.lastname: Nagashima
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hara
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Tomita
authors.forename: Shuhei
authors.initials: S
authors.lastname: Suzuki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Hirano
authors.forename: Katsuhisa
authors.initials: K
authors.lastname: Enomoto
authors.forename: Sadao
authors.initials: S
authors.lastname: Amano
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D018270:Carcinoma, Ductal, Breast / Q000628:therapy*; D018278:Carcinoma, Neuroendocrine / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen