title: Influence of dietary protein on glomerular filtration before and after bariatric surgery: a cohort study.
abstract: BACKGROUND
  Obesity-associated elevations in glomerular filtration rate (GFR) are common and may play a role in the development of kidney disease, so identifying the underlying mechanism is important. We therefore studied whether reductions in dietary protein intake, which is known to modulate GFR, explain why GFR decreases after bariatric surgery-induced weight loss.
  
  
  METHODS
  Cohort study with participants as their own controls.
  
  
  METHODS
  8 severely obese patients with normal kidney function were recruited from bariatric surgery centers in Indianapolis, IN. All participants were placed on a fixed-protein (50-g/d) diet for 1 week before and after a minimum of a 20-kg weight loss by bariatric surgery and were followed up closely by dieticians for adherence.
  
  
  METHODS
  Ad lib versus low-protein diet before versus after bariatric surgery.
  
  
  RESULTS
  Measured GFR, using repeated-measures analysis, was used to estimate the independent effects of diet and surgery.
  
  
  METHODS
  GFR was measured using plasma iohexol clearance.
  
  
  RESULTS
  A median of 32.9 (range, 19.5-54.4)kg was lost between the first presurgery visit and first postsurgery visit. Dietetic evaluations and urinary urea excretion confirmed that patients generally adhered to the study diet. GFRs on an ad lib diet were significantly higher before compared to after surgery (GFR medians were 144 (range, 114-178) and 107 (range, 85-147) mL/min, respectively; P=0.01). Although bariatric surgery (-26mL/min; P=0.005) and dietary sodium intake (+7.5mL/min per 100mg of dietary sodium; P=0.001) both influenced GFR, consuming a low-protein diet did not (P=0.7).
  
  
  CONCLUSIONS
  Small sample size; mostly white women; possible lack of generalizability.
  
  
  CONCLUSIONS
  The decrease in GFR observed after bariatric surgery is explained at least in part by the effects of surgery and/or dietary sodium intake, but not by low dietary protein consumption.
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN. Electronic address: allfried@iu.edu.
authors.forename: Allon N
authors.initials: AN
authors.lastname: Friedman
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN; Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN.
authors.forename: Sara K
authors.initials: SK
authors.lastname: Quinney
authors.affiliation: Meridian Surgical Group, Inc, Carmel, IN.
authors.forename: Margaret
authors.initials: M
authors.lastname: Inman
authors.affiliation: Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.
authors.forename: Samer G
authors.initials: SG
authors.lastname: Mattar
authors.affiliation: Department of Pathology, Wake Forest University School of Medicine, Winston-Salem, NC.
authors.forename: Zak
authors.initials: Z
authors.lastname: Shihabi
authors.affiliation: Department of Medicine, Indiana University School of Medicine, Indianapolis, IN; Department of Medicine, Roudebush Veterans Affairs Medical Center, Indianapolis, IN.
authors.forename: Sharon
authors.initials: S
authors.lastname: Moe
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015331:Cohort Studies; D018753:Diet, Protein-Restricted; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D057234:Preoperative Period; D012982:Sodium, Dietary / Q000008:administration & dosage; D015431:Weight Loss / Q000502:physiology*
chemical_list: D004044:Dietary Proteins; D012982:Sodium, Dietary
keywords: Obesity; bariatric surgery; diet; glomerular filtration rate; glomerular hyperfiltration; kidney; protein; renal function; weight reduction