title: PEGylated WS(2) nanosheets as a multifunctional theranostic agent for in vivo dual-modal CT/photoacoustic imaging guided photothermal therapy.
abstract: A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy.
authors.affiliation: Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou, Nano Science and Technology, Soochow University, Suzhou, Jiangsu, 215123, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.forename: Xing
authors.initials: X
authors.lastname: Gu
authors.forename: Hua
authors.initials: H
authors.lastname: Gong
authors.forename: Xiaoze
authors.initials: X
authors.lastname: Shi
authors.forename: Teng
authors.initials: T
authors.lastname: Liu
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Huaiyong
authors.initials: H
authors.lastname: Xing
authors.forename: Wenbo
authors.initials: W
authors.lastname: Bu
authors.forename: Baoquan
authors.initials: B
authors.lastname: Sun
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival; D005260:Female; D006367:HeLa Cells; D006801:Humans; D006979:Hyperthermia, Induced; D015674:Mammary Neoplasms, Animal / Q000473:pathology / Q000628:therapy; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D049329:Nanostructures / Q000009:adverse effects / Q000737:chemistry; D009368:Neoplasm Transplantation; D010789:Phototherapy / Q000379:methods*; D011092:Polyethylene Glycols / Q000009:adverse effects / Q000737:chemistry; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D017973:Tungsten Compounds / Q000009:adverse effects / Q000737:chemistry
chemical_list: D017973:Tungsten Compounds; D011092:Polyethylene Glycols
keywords: CT imaging; PAT imaging; Photothermal therapy; WS2 nanosheet