title: Serum interleukin-10 levels and adverse events in patients with acute coronary syndrome: a systematic review and meta-analysis.
abstract: BACKGROUND
  Several studies investigating the prognostic utility of interleukin-10 (IL-10) in patients with acute coronary syndrome (ACS) have provided conflicting findings. The aim of the study was to assess the existing evidence regarding association between serum IL-10 levels and adverse events.
  
  
  METHODS
  Literature search was performed in PubMed, EMBASE, and Cochrane Trials Register databases from their inception to September 30, 2012. In addition, reference lists of the included articles and their related citations in PubMed were also reviewed for additional pertinent studies.
  
  
  RESULTS
  A total of 12 eligible studies comprising a total of 5882 patients were identified. The pooled relative risks for both studies reporting the risk estimates by IL-10 categories and studies reporting the risk estimates by unit IL-10 indicated an association between high IL-10 levels and adverse events. Sensitivity and subgroup analysis indicated that the results obtained in IL-10 categories were not stable.
  
  
  CONCLUSIONS
  Data from our meta-analysis supported the existence of a relationship between high serum IL-10 levels and adverse events in patients with ACS. Large study with longer follow-up is needed to confirm the findings.
authors.affiliation: Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Jia
authors.affiliation: Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Li
authors.affiliation: Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Ruixia
authors.initials: R
authors.lastname: Xu
authors.affiliation: Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Chenggang
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Yuanlin
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
authors.forename: Naqiong
authors.initials: N
authors.lastname: Wu
authors.affiliation: Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China. Email: lijianjun938@yahoo.com.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Li
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*
chemical_list: D016753:Interleukin-10