title: Hypogonadism and erectile dysfunction in myotonic dystrophy type 1.
abstract: Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults. It affects many organs and systems besides muscle. Aim of this study was to assess frequency of erectile dysfunction (ED) and hypogonadism, the correlation between them and the impact of ED on quality of life (QoL) in patients with DM1. A series of 25 men (aged from 22 to 58 years) with a diagnosis of DM1 was analyzed. Muscular Impairment Rating Scale (MIRS) was used to assess severity of muscular involvement. Erectile function was assessed using the short form of the International Index of Erectile Function test (IIEF-5). Levels of follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone were assessed. All patients completed the Serbian version of the SF-36 questionnaire as a measure of health-related QoL. ED was present in 18 (72%) of patients. Seven (28%) patients were euogonadic, 16 (64%) had compensated hypogonadism and 2 (8%) had primary hypogonadism. ED was somewhat more common in patients with hypogonadism (78% vs. 57%). Mental composite score of SF-36 was lower in patients with ED (p<0.05). Our results showed that 72% of men with DM1 had ED and hypogonadism. Studies with larger number of subjects are needed to resolve cascade of events that lays behind ED in DM1. Development of therapeutic strategies may have positive impact on QoL. Substitutive therapy with androgens may be benefitial.
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Stojan
authors.initials: S
authors.lastname: Peric
authors.affiliation: Institute of Endocrinology, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
authors.forename: Tanja
authors.initials: T
authors.lastname: Nisic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Milena
authors.initials: M
authors.lastname: Milicev
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Ivana
authors.initials: I
authors.lastname: Basta
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Ivan
authors.initials: I
authors.lastname: Marjanovic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Marina
authors.initials: M
authors.lastname: Peric
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Dragana
authors.initials: D
authors.lastname: Lavrnic
authors.affiliation: Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
authors.forename: Vidosava
authors.initials: V
authors.lastname: Rakocevic Stojanovic
mesh_terms: D000328:Adult; D017668:Age of Onset; D003710:Demography; D007172:Erectile Dysfunction / Q000209:etiology / Q000523:psychology; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009123:Muscle Hypotonia / Q000209:etiology / Q000503:physiopathology; D009223:Myotonic Dystrophy / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D011788:Quality of Life; D055771:Serbia / Q000453:epidemiology; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone
keywords: erectile dysfunction; hypogonadis; myotonic dystrophy type 1