title: Evaluation of prenatal risk factors for prediction of outcome in right heart lesions: CVP score in fetal right heart defects.
abstract: OBJECTIVE
  To determine the prenatal variables predicting the risk of perinatal death in congenital right heart defects.
  
  
  METHODS
  Retrospective analysis of 28 fetuses with right heart defects was performed. Logistic regression analyses were performed to obtain odds ratios (OR) for the relationship between the risk of death and echocardiographic parameters. The parameters that correlated with the outcome were incorporated in an attempt to devise a disease-specific cardiovascular profile score.
  
  
  RESULTS
  Fetal echocardiograms (143) from 28 patients were analyzed. The cardiovascular profile score predicted the risk of death. A lower right ventricle (RV) pressure was associated with mortality (OR 0.959; 95% confidence intervals (CI) 0.940-0.978). Higher peak aortic velocity through the aortic valve (OR 0.104; 95% CI 0.020-0.529) was associated with a better outcome. These cardiac function parameters were incorporated in a modified disease-specific CVP Score. Patients with a mean modified cardiovascular profile score of ≤ 6 were over 3.7 times more likely to die than those with scores of 7-10.
  
  
  CONCLUSIONS
  The original Cardiovascular Profile Score predicted the risk of death in right heart defects. The modified score was not validated as a good prediction tool by this study. Fetal RV pressure estimate and peak aortic velocity can be used as independent prognostic predictors.
authors.affiliation: Hospital S. João , Porto , Portugal .
authors.forename: Ana Luisa
authors.initials: AL
authors.lastname: Neves
authors.forename: Leigh
authors.initials: L
authors.lastname: Mathias
authors.forename: Marilyn
authors.initials: M
authors.lastname: Wilhm
authors.forename: Jennifer
authors.initials: J
authors.lastname: Leshko
authors.forename: Kersti K
authors.initials: KK
authors.lastname: Linask
authors.forename: Tiago
authors.initials: T
authors.lastname: Henriques-Coelho
authors.forename: José C
authors.initials: JC
authors.lastname: Areias
authors.forename: James C
authors.initials: JC
authors.lastname: Huhta
mesh_terms: D001724:Birth Weight; D004452:Echocardiography / Q000379:methods; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D018873:Pregnancy Rate; D011379:Prognosis; D012107:Research Design; D012189:Retrospective Studies; D012307:Risk Factors; D016216:Ultrasonography, Prenatal
keywords: Congenital heart defects; fetal echocardiography; outcomes