title: Expression of EGFR and p53 in head and neck tumors among Sudanese patients.
abstract: BACKGROUND
  The aim of this study was to assess EGFR and p53 expression in head and neck tumors among Sudanese patients using immunohistochemistry.
  
  
  METHODS
  A retrospective descriptive study was performed on 150 samples from patients diagnosed with HNCs as well as 50 from individuals with benign head and neck tumors. EGFR and p53 expression was assessed using immunohistochemistry (IHC).
  
  
  RESULTS
  EGFR was expressed in 126/150 (84%) of HNCS and 6/50 (12%) benign head and neck tumors where as p53 was expressed in 29/150 (19.3%) of HNCs and 2/50 (4%) of benign head and neck tumors, with significance at p values of 0.001 and 0.009 respectively.
  
  
  CONCLUSIONS
  There is a significant association between EGFR, P53 expression and head and neck cancers among Sudanese patients.
authors.affiliation: Department of Histopathology and Cytology, Faculty of Medical laboratory Sciences, Elneelain University, Sudan E-mail : Hussaingad1972@yahoo.com, he.ahmed@uoh.edu.sa.
authors.forename: Mustafa Saadalnour
authors.initials: MS
authors.lastname: Abusail
authors.forename: Ahmed Mohmed Ahmed
authors.initials: AM
authors.lastname: Dirweesh
authors.forename: Rashid Awad Abdalla
authors.initials: RA
authors.lastname: Salih
authors.forename: Ahmed Hussain
authors.initials: AH
authors.lastname: Gadelkarim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D066246:ErbB Receptors / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D006258:Head and Neck Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013397:Sudan; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics*; D055815:Young Adult
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C512478:EGFR protein, human; D066246:ErbB Receptors