title: Time trends of human papillomavirus types in invasive cervical cancer, from 1940 to 2007.
abstract: Contribution over time of human papillomavirus (HPV) types in human cancers has been poorly documented. Such data is fundamental to measure current HPV vaccines impact in the years to come. We estimated the HPV type-specific distribution in a large international series of invasive cervical cancer (ICC) over 70 years prior to vaccination. Paraffin embedded ICC cases diagnosed between 1940 and 2007 were retrieved from eleven countries in Central-South America, Asia and Europe. Included countries reported to have low-medium cervical cancer screening uptake. Information on age at and year of diagnosis was collected from medical records. After histological confirmation, HPV DNA detection was performed by SPF-10/DEIA/LiPA25 (version1). Logistic regression models were used for estimating the adjusted relative contributions (RC) of HPV16 and of HPV18 over time. Among 4,771 HPV DNA positive ICC cases, HPV16 and HPV18 were the two most common HPVs in all the decades with no statistically significant variations of their adjusted-RC from 1940-59 to 2000-07 (HPV16-from 61.5 to 62.1%, and HPV18-from 6.9 to 7.2%). As well, the RC of other HPV types did not varied over time. In the stratified analysis by histology, HPV16 adjusted-RC significantly increased across decades in adenocarcinomas. Regarding age, cases associated to either HPV16, 18 or 45 were younger than those with other HPV types in all the evaluated decades. The observed stability on the HPV type distribution predicts a high and stable impact of HPV vaccination in reducing the cervical cancer burden in future vaccinated generations.
authors.affiliation: Unit of Infections and Cancer, Catalan Institute of Oncology, IDIBELL, Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain.
authors.forename: Laia
authors.initials: L
authors.lastname: Alemany
authors.forename: Silvia
authors.initials: S
authors.lastname: de Sanjosé
authors.forename: Sara
authors.initials: S
authors.lastname: Tous
authors.forename: Wim
authors.initials: W
authors.lastname: Quint
authors.forename: Carlos
authors.initials: C
authors.lastname: Vallejos
authors.forename: Hai-Rim
authors.initials: HR
authors.lastname: Shin
authors.forename: Luis E
authors.initials: LE
authors.lastname: Bravo
authors.forename: Patricia
authors.initials: P
authors.lastname: Alonso
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Lima
authors.forename: Núria
authors.initials: N
authors.lastname: Guimerà
authors.forename: Joellen
authors.initials: J
authors.lastname: Klaustermeier
authors.forename: Antonio
authors.initials: A
authors.lastname: Llombart-Bosch
authors.forename: Elena
authors.initials: E
authors.lastname: Kasamatsu
authors.forename: Silvio A
authors.initials: SA
authors.lastname: Tatti
authors.forename: Ana
authors.initials: A
authors.lastname: Felix
authors.forename: Carla
authors.initials: C
authors.lastname: Molina
authors.forename: Julio
authors.initials: J
authors.lastname: Velasco
authors.forename: Belen
authors.initials: B
authors.lastname: Lloveras
authors.forename: Omar
authors.initials: O
authors.lastname: Clavero
authors.forename: Enrique
authors.initials: E
authors.lastname: Lerma
authors.forename: Jan
authors.initials: J
authors.lastname: Laco
authors.forename: Ignacio G
authors.initials: IG
authors.lastname: Bravo
authors.forename: Rosa
authors.initials: R
authors.lastname: Guarch
authors.forename: Adela
authors.initials: A
authors.lastname: Pelayo
authors.forename: Jaume
authors.initials: J
authors.lastname: Ordi
authors.forename: Miguel
authors.initials: M
authors.lastname: Andújar
authors.forename: Gloria I
authors.initials: GI
authors.lastname: Sanchez
authors.forename: Xavier
authors.initials: X
authors.lastname: Castellsagué
authors.forename: Nubia
authors.initials: N
authors.lastname: Muñoz
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Bosch
mesh_terms: D000328:Adult; D000368:Aged; D001208:Asia; D002489:Central America; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D055088:Early Detection of Cancer; D005060:Europe; D005260:Female; D052162:Human papillomavirus 16 / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D052161:Human papillomavirus 18 / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000235:genetics* / Q000473:pathology; D016612:Paraffin Embedding; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology* / Q000821:virology
chemical_list: D004279:DNA, Viral
keywords: cervical cancer; human papillomavirus; time trends; types