title: Total synthesis of the antibiotic elansolid B1.
abstract: The antibiotic elansolid B1 was prepared by a convergent strategy that relied on a highly diastereoselective, biomimetic intramolecular Diels-Alder cycloaddition (IMDA) that furnished the tetrahydroindane unit. Other key features are a double Sonogashira cross-coupling and a substrate-controlled Yamamoto aldol reaction.
authors.affiliation: Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum (BMWZ), Leibniz Universität Hannover , Schneiderberg 1B, 30167 Hannover, Germany.
authors.forename: Arne
authors.initials: A
authors.lastname: Weber
authors.forename: Richard
authors.initials: R
authors.lastname: Dehn
authors.forename: Nadin
authors.initials: N
authors.lastname: Schläger
authors.forename: Bastian
authors.initials: B
authors.lastname: Dieter
authors.forename: Andreas
authors.initials: A
authors.lastname: Kirschning
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D032701:Biomimetics; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C559179:elansolid B1