title: In vitro interaction between SURFACEN® and surfactant protein A against Leishmania amazonensis.
abstract: Leishmaniasis is caused by a parasite of the Leishmania genus, affecting more than 12 million people in 98 countries. The control of leishmaniasis remains a serious problem. There are currently no vaccines for leishmaniasis. The drugs available are toxic, expensive and frequently ineffective. The in vitro activity of SURFACEN® and SP-A against Leishmania amazonensis was evaluated. The combination of both products resulted in a synergic pharmacology effect, demonstrated by a fractional inhibitory concentration index <0.5. A more effective combination was a SURFACEN/SP-A ratio of 4:1, using a method of fixed ratio. The therapeutic effect of SURFACEN and SP-A as antileishmanial compounds was demonstrated, with a potentiation of activity when they were incubated in conjunction. Our results propose an exploration of these products in order to design new formulations against the Leishmania parasite.
authors.affiliation: Grupo de Química-Farmacología-Toxicología, Centro Nacional de Sanidad Agropecuaria (CENSA), Mayabeque, Cuba.
authors.forename: Yuliannis Lugones Ladrón
authors.initials: YL
authors.lastname: de Guevara
authors.forename: Odalys Blanco
authors.initials: OB
authors.lastname: Hidalgo
authors.forename: Roberto
authors.initials: R
authors.lastname: Faure
authors.forename: Lianet Monzote
authors.initials: LM
authors.lastname: Fidalgo
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology; D004357:Drug Synergism; D007891:Leishmania / Q000187:drug effects* / Q000302:isolation & purification; D008264:Macrophages / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D010743:Phospholipids / Q000494:pharmacology*; D037662:Pulmonary Surfactant-Associated Protein A / Q000494:pharmacology*; D037661:Pulmonary Surfactant-Associated Proteins / Q000494:pharmacology*; D013552:Swine
chemical_list: D000977:Antiparasitic Agents; D010743:Phospholipids; D037662:Pulmonary Surfactant-Associated Protein A; D037661:Pulmonary Surfactant-Associated Proteins; C569617:surfacen