title: Control of the development and prevalence of antimicrobial resistance in bacteria of food animal origin in Japan: a new approach for risk management of antimicrobial veterinary medicinal products in Japan.
abstract: Antimicrobial agents are essential for controlling bacterial disease in food-producing animals and contribute to the stable production of safe animal products. The use of antimicrobial agents in these animals affects the emergence and prevalence of antimicrobial resistance in bacteria isolated from animals and animal products. As disease-causing bacteria are often transferred from food-producing animals to humans, the food chain is considered a route of transmission for the resistant bacteria and/or resistance genes. The Food Safety Commission of Japan (FSC) has been assessing the risk posed to human health by the transmission of antimicrobial-resistant bacteria from livestock products via the food chain. In addition to the FSC's risk assessments, the Japanese Ministry of Agriculture, Forestry and Fisheries has developed risk-management guidelines to determine feasible risk-management options for the use of antimicrobial veterinary medicinal products during farming practices. This report includes information on risk assessment and novel approaches for risk management of antimicrobial veterinary medicinal products for mitigating the risk of development and prevalence of antimicrobial resistance in bacteria originating from food-producing animals in Japan.
authors.affiliation: 1 National Veterinary Assay Laboratory , Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan .
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Asai
authors.forename: Mototaka
authors.initials: M
authors.lastname: Hiki
authors.forename: Manao
authors.initials: M
authors.lastname: Ozawa
authors.forename: Ryoji
authors.initials: R
authors.lastname: Koike
authors.forename: Kaoru
authors.initials: K
authors.lastname: Eguchi
authors.forename: Michiko
authors.initials: M
authors.lastname: Kawanishi
authors.forename: Akemi
authors.initials: A
authors.lastname: Kojima
authors.forename: Yuuko S
authors.initials: YS
authors.lastname: Endoh
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hamamoto
authors.forename: Masato
authors.initials: M
authors.lastname: Sakai
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Sekiya
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D020387:Food Chain; D005516:Food Microbiology / Q000331:legislation & jurisprudence*; D059022:Food Safety; D005517:Foodborne Diseases / Q000382:microbiology*; D006077:Government Agencies; D017408:Guidelines as Topic; D006801:Humans; D007564:Japan; D058751:Livestock; D008460:Meat / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D012308:Risk Management; D014730:Veterinary Medicine
chemical_list: D000890:Anti-Infective Agents