title: Effect of low power laser on incisional wound healing.
abstract: BACKGROUND
  The effectiveness of low power lasers for incisional wound healing, because of conflicting results of previous research studies, is uncertain. Therefore, this study was carried out to evaluate low power laser effects on incisional wound healing.
  
  
  METHODS
  Incisional wound was produced on thirty-six mature male guinea pigs under general and local anesthesia. In half of the cases, HeNe laser radiations were used for five minutes and the rest were left untreated Animals were divided into six groups of six animals each that were killed after 3, 5 and 14 days. After histopathology processing and H&E staining, specimens were examined for acute and chronic inflammations, epithelial cell migration, epithelial seal and barrier formation, fibroblast migration, fibrosis, clot formation and granulation tissue formation. Mann-Whitney U and the Wilcoxon tests were used for statistical analysis.
  
  
  RESULTS
  Statistically significant differences were found between fibroblast migration, acute and chronic inflammation of radiated groups and the control group at 5 days interval (p<0.05). There was no statistically significant difference at 3 and 14 days between laser radiated and control groups.
  
  
  CONCLUSIONS
  This study showed that HeNe laser had beneficial effects on incisional wound healing particularly at 5 days interval; however, further research on chronic ulcers is recommended.
authors.affiliation: Department of Endodontics, Dental School, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Parirokh
authors.affiliation: Department of Pathology, Medical School, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Shahriar
authors.initials: S
authors.lastname: Dabiri
authors.affiliation: Department of Mathematics, Vali-Asr Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Bahrampour
authors.affiliation: General Practitioner, Rafsanjan, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Homayon Zadeh
authors.affiliation: Department of Endodontics, Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Jafar
authors.initials: MJ
authors.lastname: Eghbal
keywords: HeNe laser; Healing; Incisional wound; Low power laser