title: Biochemical markers in total intravenous anesthesia and propofol infusion syndrome: a preliminary study.
abstract: OBJECTIVE
  To investigate biochemically whether total intravenous anesthesia (TIVA) using propofol creates a risk for Propofol Infusion Syndrome (PRIS).
  
  
  METHODS
  Forty patients scheduled for thyroid gland surgery were randomly assigned into Group T or C and premedicated 30 min before operation. Group T received remifentanyl hydrochloride, propofol infusion following anesthesia induction with propofol, vecuronium bromide and intubation. Group C received remifentanyl hydrochloride infusion, 1-1.5 MAC desflurane inhalation following anesthesia induction with thiopental, vecuronium bromide and intubation. Patients were respired 50% O2-air mixture. Blood gas, potassium, lactic acid, CK-MB, myoglobin, troponin I, total carnitine, triglyceride, creatinine concentrations were determined before operation, at intraoperative hour-2, postoperative hour-6.
  
  
  RESULTS
  There were no significant differences between groups in potassium, lactic acid CK-MB, myoglobin, total carnitine or creatinine levels. Triglyceride level at intraoperative hour-2 increased in Group T, decreased at postoperative hour-6. Troponin I was higher in Group C than Group T at intraoperative hour-2 (p < 0.05). No asystole, bradycardia, arrhythmia, hypotension or change in urine color was detected.
  
  
  CONCLUSIONS
  The present biochemical findings suggest that TIVA using propofol is safe.
authors.affiliation: Department of Anesthesiology, School of Medicine, Pamukkale University, Denizli, Turkey. elgurses@gmail.com.
authors.forename: I
authors.initials: I
authors.lastname: Oztürk
authors.forename: S
authors.initials: S
authors.lastname: Serin
authors.forename: E
authors.initials: E
authors.lastname: Gürses
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000771:Anesthesia, Intravenous / Q000009:adverse effects* / Q000379:methods; D019162:Anesthetics, Combined / Q000008:administration & dosage / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D064420:Drug-Related Side Effects and Adverse Reactions / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D010865:Pilot Projects; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D012121:Respiration, Artificial; D012307:Risk Factors; D013577:Syndrome; D013961:Thyroid Gland / Q000601:surgery*; D013997:Time Factors; D014421:Turkey
chemical_list: D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D015415:Biomarkers; D015742:Propofol