title: Biological mesh in contaminated fields--overuse without data: a systematic review of their use in abdominal wall reconstruction.
abstract: Ventral hernia repair in contaminated fields is a significant problem for surgeons. We performed a systematic review regarding the use of biological mesh in contaminated fields for abdominal wall reconstruction. The primary end points were recurrence and infection of the hernia repair. An independent search of scientific papers in the English language was performed by three reviewers. Articles were chosen based on reference to ventral hernias, their use in infected fields, and in human subjects. Papers were scored using the Methodological Index for Non-Randomized Studies and those with a score of 8 or more were combined to evaluate the end points. A total of 16 studies from six different mesh products met our criteria. These papers comprised 554 patients with an overall infection rate of 24 per cent and a recurrence rate of 20 per cent. The largest study used 116 patients. All papers were case series. Overall the data for use of biological mesh products in contaminated fields are limited. Further controlled studies are needed to address this important and clinically relevant question. Caution should be used when using biological mesh products in infected fields because there is a paucity of controlled data and none have U.S. Food and Drug Administration approval for use in infected fields.
authors.affiliation: Department of Surgery, Saint Agnes Hospital, Baltimore, Maryland, USA.
authors.forename: Wirt
authors.initials: W
authors.lastname: Cross
authors.forename: Ajay
authors.initials: A
authors.lastname: Kumar
authors.forename: Gopal
authors.initials: G
authors.lastname: Chandru Kowdley
mesh_terms: D034861:Abdominal Wall / Q000601:surgery; D058107:Abdominal Wound Closure Techniques / Q000295:instrumentation*; D062088:Acellular Dermis / Q000009:adverse effects / Q000706:statistics & numerical data*; D001672:Biocompatible Materials / Q000009:adverse effects; D006555:Hernia, Ventral / Q000382:microbiology / Q000517:prevention & control / Q000601:surgery*; D059685:Herniorrhaphy / Q000295:instrumentation* / Q000379:methods; D006801:Humans; D055502:Secondary Prevention; D013526:Surgical Mesh / Q000009:adverse effects / Q000706:statistics & numerical data*; D013530:Surgical Wound Infection / Q000209:etiology* / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials