title: Therapeutic drug monitoring (TDM) of antifungal agents: guidelines from the British Society for Medical Mycology.
abstract: The burden of human disease related to medically important fungal pathogens is substantial. An improved understanding of antifungal pharmacology and antifungal pharmacokinetics-pharmacodynamics has resulted in therapeutic drug monitoring (TDM) becoming a valuable adjunct to the routine administration of some antifungal agents. TDM may increase the probability of a successful outcome, prevent drug-related toxicity and potentially prevent the emergence of antifungal drug resistance. Much of the evidence that supports TDM is circumstantial. This document reviews the available literature and provides a series of recommendations for TDM of antifungal agents.
authors.affiliation: Mycology Reference Centre, Department of Microbiology, Leeds Teaching Hospitals NHS Trust, Leeds LS1 3EX, UK.
authors.forename: H Ruth
authors.initials: HR
authors.lastname: Ashbee
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Barnes
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Johnson
authors.forename: Malcolm D
authors.initials: MD
authors.lastname: Richardson
authors.forename: Rebecca
authors.initials: R
authors.lastname: Gorton
authors.forename: William W
authors.initials: WW
authors.lastname: Hope
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000379:methods* / Q000592:standards*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy*; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents
keywords: fungal diseases; fungal pathogens; triazoles