title: Assessment of inflamed synovial membrane in the knee joint by dynamic magnetic resonance imaging.
abstract: Abstract Dynamic magnetic resonance imaging (dynamic MRI) was used to examine the synovial membrane in the knee joints of 15 patients with rheumatoid arthritis (RA) in order to investigate the relationship between pathological and MRI findings. Signal intensities in the regions of interest (ROI), identified as the synovial membrane of the suprapatellar pouch, were measured on MR images. Signal intensities at various times after the injection of contrast medium Gd-diethylenetriaminopentoacetic acid (Gd-DTPA) were normalized relative to the signal intensity at 80 s, and designated as the normalized signal intensity (NSI). Pathological findings were quantified, and the types of inflamed synovial membrane were classified as either acute or chronic. A significant difference in NSI was observed between acute and chronic types (P < 0.05). Dynamic MRI was capable of classifying acute and chronic RA by measuring NSI 20 s after contrast medium injection. Dynamic MRI was therefore shown to be useful for assessing regional synovial inflammation.
authors.affiliation: Kitasato University Graduate School of Medical Science , 1-15-1 Kitasato, Sagamihara 228-8555 , Japan.
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Kawai
authors.forename: Akito
authors.initials: A
authors.lastname: Nishimura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ikeda
authors.forename: Hirahito
authors.initials: H
authors.lastname: Endo
authors.forename: Miyoko
authors.initials: M
authors.lastname: Rana
authors.forename: Moritoshi
authors.initials: M
authors.lastname: Itoman
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Sakurai