title: [Development of lecithinized superoxide dismutase as a drug for IPF].
abstract: Idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD) are thought to involve lung injury induced by reactive oxygen species (ROS), in particular superoxide anion. The enzyme, superoxide dismutase (SOD) catalyses the dismutation of superoxide anion to hydrogen peroxide. Lecithinized SOD (PC-SOD) has overcome a number of previous clinical limitations of SOD, including low tissue affinity and low stability in plasma. Recent animal studies suggest that PC-SOD is effective for the treatment of IPF and COPD. We are now performing the clinical study of PC-SOD for IPF patients.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy, Keio University.
authors.forename: Tohru
authors.initials: T
authors.lastname: Mizushima
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000009:adverse effects; D006801:Humans; D010713:Phosphatidylcholines / Q000737:chemistry* / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000139:chemically induced / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D010713:Phosphatidylcholines; D001761:Bleomycin; D013482:Superoxide Dismutase; C434045:lecithinized superoxide dismutase