title: Hypotonia and poor feeding in an infant exposed to lamotrigine and valproic acid in utero.
abstract: Lamotrigine has been considered a safe new-generation antiepileptic drug during the perinatal period for both mothers and infants. Despite the concerns regarding its possible teratogenic effect, very limited data have been reported on the adverse effects of perinatal lamotrigine exposure. Herein, we report a case of an infant with hypotonicity and poor feeding who was exposed to lamotrigine in utero. The drug interaction probability scale indicated a probable relationship between sepsis-like symptoms and exposure to lamotrigine and valproic acid in utero in this infant.
authors.affiliation: Division of Neonatology, Hacettepe University Faculty of Medicine, Ankara, Turkey. stakci@gmail.com.
authors.forename: Sahin
authors.initials: S
authors.lastname: Takcı
authors.forename: Cihangül
authors.initials: C
authors.lastname: Bayhan
authors.forename: Tolga
authors.initials: T
authors.lastname: Celik
authors.forename: Sule
authors.initials: S
authors.lastname: Yiğit
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D000077213:Lamotrigine; D008431:Maternal-Fetal Exchange; D009123:Muscle Hypotonia / Q000139:chemically induced*; D011247:Pregnancy; D013391:Sucking Behavior; D014227:Triazines / Q000009:adverse effects* / Q000378:metabolism; D014635:Valproic Acid / Q000009:adverse effects* / Q000378:metabolism
chemical_list: D000927:Anticonvulsants; D014227:Triazines; D014635:Valproic Acid; D000077213:Lamotrigine