title: The role of glioma stem cells in glioma tumorigenesis.
abstract: Malignant gliomas, the most common type of primary brain tumor, account for 80% of malignant tumors in the central nervous system (CNS). There are three principal types of glioma: astrocytomas, oligodendrogliomas, and oligoastrocytomas. Glioma stem cells (GSCs) have been found in all types; however, many fundamental questions about GSCs remain unanswered. This review will examine the current state of knowledge regarding GSC origin and the signaling pathways implicated in GSC tumorigenesis. The outstanding challenges for the study of GSCs in the context of glioma progression will also be discussed.
authors.affiliation: Department of Emergency, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba Area, Chongqing 400038, China.
authors.forename: Chang-lin
authors.initials: CL
authors.lastname: Yin
authors.affiliation: Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Sheng-qing
authors.initials: SQ
authors.lastname: Lv
authors.affiliation: Department of Emergency, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba Area, Chongqing 400038, China.
authors.forename: Xiang-yu
authors.initials: XY
authors.lastname: Chen
authors.affiliation: Department of Emergency, Southwest Hospital, Third Military Medical University, 30 Gaotanyan Street, Shapingba Area, Chongqing 400038, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Guo
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D063646:Carcinogenesis; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor