title: Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC).
abstract: Management of metastatic colorectal cancer requires a multimodal approach and must be performed by an experienced, multidisciplinary expert team. The optimal choice of the individual treatment modality, according to disease localization and extent, tumor biology, and patient clinical characteristics, will be one that can maintain quality of life and long-term survival, and even cure selected patients. This review is an overview of the different therapeutic approaches available in metastatic colorectal cancer, for the purpose of defining personalized therapeutic algorithms according to tumor biology and patient clinical features.
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Rossi
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Foteini
authors.initials: F
authors.lastname: Vakiarou
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Zoratto
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Loredana
authors.initials: L
authors.lastname: Bianchi
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Anselmo
authors.initials: A
authors.lastname: Papa
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Enrico
authors.initials: E
authors.lastname: Basso
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Verrico
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lo Russo
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Evangelista
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Guilia
authors.initials: G
authors.lastname: Rinaldi
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Perrone-Congedi
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Spinelli
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Stati
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Caruso
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Prete
authors.affiliation: Department of Medico-Surgical Sciences and Biotechnologies, "Sapienza" University of Rome, Rome, Italy; Oncology Unit, ICOT, Latina, Italy.
authors.forename: Silverio
authors.initials: S
authors.lastname: Tomao
keywords: metastatic colorectal cancer; multidisciplinary approach; patient clinical features; tumor biology