title: Automatic sorting of toxicological information into the IUCLID (International Uniform Chemical Information Database) endpoint-categories making use of the semantic search engine Go3R.
abstract: The knowledge-based search engine Go3R, www.Go3R.org, has been developed to assist scientists from industry and regulatory authorities in collecting comprehensive toxicological information with a special focus on identifying available alternatives to animal testing. The semantic search paradigm of Go3R makes use of expert knowledge on 3Rs methods and regulatory toxicology, laid down in the ontology, a network of concepts, terms, and synonyms, to recognize the contents of documents. Search results are automatically sorted into a dynamic table of contents presented alongside the list of documents retrieved. This table of contents allows the user to quickly filter the set of documents by topics of interest. Documents containing hazard information are automatically assigned to a user interface following the endpoint-specific IUCLID5 categorization scheme required, e.g. for REACH registration dossiers. For this purpose, complex endpoint-specific search queries were compiled and integrated into the search engine (based upon a gold standard of 310 references that had been assigned manually to the different endpoint categories). Go3R sorts 87% of the references concordantly into the respective IUCLID5 categories. Currently, Go3R searches in the 22 million documents available in the PubMed and TOXNET databases. However, it can be customized to search in other databases including in-house databanks.
authors.affiliation: Scientific Consultancy - Animal Welfare, Neubiberg, Germany.
authors.forename: Ursula G
authors.initials: UG
authors.lastname: Sauer
authors.affiliation: Biotechnology Center, Technische Universität Dresden, Dresden, Germany; Transinsight GmbH, Dresden, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Wächter
authors.affiliation: BASF SE, Product Safety - Experimental Toxicology and Ecology, Ludwigshafen, Germany.
authors.forename: Lars
authors.initials: L
authors.lastname: Hareng
authors.affiliation: BASF SE, Product Safety - Experimental Toxicology and Ecology, Ludwigshafen, Germany.
authors.forename: Britta
authors.initials: B
authors.lastname: Wareing
authors.affiliation: BASF SE, Product Safety - Experimental Toxicology and Ecology, Ludwigshafen, Germany.
authors.forename: Angelika
authors.initials: A
authors.lastname: Langsch
authors.affiliation: Transinsight GmbH, Dresden, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Zschunke
authors.affiliation: Transinsight GmbH, Dresden, Germany.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Alvers
authors.affiliation: BASF SE, Product Safety - Experimental Toxicology and Ecology, Ludwigshafen, Germany. Electronic address: robert.landsiedel@basf.com.
authors.forename: Robert
authors.initials: R
authors.lastname: Landsiedel
mesh_terms: D000826:Animal Testing Alternatives / Q000379:methods*; D000827:Animal Welfare; D000818:Animals; D035843:Biomedical Research / Q000379:methods; D016208:Databases, Factual; D004282:Documentation; D015386:Hazardous Substances / Q000633:toxicity*; D012107:Research Design; D057386:Search Engine; D009626:Terminology as Topic
chemical_list: D015386:Hazardous Substances
keywords: 3Rs principle; Alternative methods; Data sharing; REACH; Registration dossiers; Regulatory toxicology; Semantic search engine