title: [Disease-free survival related factors in breast cancer].
abstract: OBJECTIVE
  To evaluate the relationship between the clinical and pathological parameters of the primary tumor and disease-free survival (DFS) in a sample of hospital cases of invasive breast cancer.
  
  
  METHODS
  We performed a retrospective cohort study in 635 patients recruited at San Cecilio University Hospital in Granada (Spain) between 1994 and 2006. Information on the primary tumor and the outcomes of patients was collected by reviewing the medical records. Predictors of recurrence and/or metastasis and DFS (follow up of 3, 5 and 10 years) were analyzed by using Cox regression analysis.
  
  
  RESULTS
  Multivariate models adjusted for age, tumor size, lymph nodal status, histological grade and estrogen and progesterone receptor expression showed a higher risk of recurrence and/or metastasis and lower DFS (adjusted relative risk, 95% confidence intervals) with tumor size (3 yrs: 3.00, 1.79-5.03; 5 yrs: 2.56, 1.65-3.98; 10 yrs: 2.16, 1.44-3.24), lymph nodal status (3 yrs: 4.58, 2.42-8.65; 5 yrs: 3.84, 2.35-6.30; 10 yrs: 3.08, 2.05-4.61), lymphovascular invasion (5 yrs: 1.88, 1.16-3.04; 10 yrs: 2.19, 1.43-3.35), multifocal and/or multicenter tumors (3 yrs: 2.69, 1.46-4.96; 5 yrs: 1.90, 1.08-3.35) and p53 protein expression (3 yrs: 2.03, 1.00-4.09). DFS was positively associated with an increased expression of progesterone receptor (3 yr: 0.48, 0.26-0.89; 5 yrs: 0.58, 0.35-0.97; 10 yrs: 0.59, 0.38-0.90).
  
  
  CONCLUSIONS
  The biological characteristics of the primary tumor can be used to identify patients with distinctive prognoses and DFS, and could be helpful in making individual follow up strategies.
authors.affiliation: Unidad de Apoyo a la Investigación, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario San Cecilio, Granada, España. Electronic address: crisdavilaarias@yahoo.es.
authors.forename: Cristina
authors.initials: C
authors.lastname: Dávila-Arias
authors.affiliation: Departamento de Ginecología y Obstetricia, Universidad de Granada, Granada, España.
authors.forename: Olga
authors.initials: O
authors.lastname: Ocón
authors.affiliation: Unidad de Apoyo a la Investigación, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario San Cecilio, Granada, España; Departamento de Radiología, Universidad de Granada, Granada, España; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Granada, España.
authors.forename: Mariana F
authors.initials: MF
authors.lastname: Fernández
authors.affiliation: Unidad de Apoyo a la Investigación, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario San Cecilio, Granada, España; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Granada, España.
authors.forename: Juan Pedro
authors.initials: JP
authors.lastname: Arrebola
authors.affiliation: Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Granada, España; Escuela Andaluza de Salud Pública, Registro de Cáncer de Granada, Granada, España.
authors.forename: María José
authors.initials: MJ
authors.lastname: Sánchez
authors.affiliation: Departamento de Anatomía Patológica, Universidad de Granada, Granada, España.
authors.forename: José
authors.initials: J
authors.lastname: Aneiros
authors.affiliation: Departamento de Cirugía, Universidad de Granada, Granada, España.
authors.forename: Pablo
authors.initials: P
authors.lastname: Torné
authors.affiliation: Unidad de Apoyo a la Investigación, Instituto de Investigación Biosanitaria de Granada, Hospital Universitario San Cecilio, Granada, España; Departamento de Radiología, Universidad de Granada, Granada, España; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Granada, España.
authors.forename: Nicolás
authors.initials: N
authors.lastname: Olea
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery*; D018275:Carcinoma, Lobular / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Breast cancer; Cáncer de mama; Disease-free survival; Local recurrence; Metastasis; Metástasis; Recidiva local; Supervivencia libre de enfermedad