title: Use of aglepristone for the treatment of P4 induced insulin resistance in dogs.
abstract: Insulin resistance (IR) in dogs is suspected when hyperglycemia is present despite administration of insulin doses greater than 1.0 to 1.5 UI/kg. IR is caused by increases in counter regulatory hormones concentrations (glucagon, glucocorticoids, catecholamines and growth hormone). This study was conducted to investigate the use of aglepristone (RU 46534), a P4 receptor antagonist, for the treatment of IR diabetes mellitus in bitches during the luteal phase. All animals were treated with porcine insulin zinc suspension (Caninsulin) and aglepristone (Alizin) 10 mg/kg subcutaneously at day 1, 2, 9 and 17 from diagnosis. At day 5, no significant variation in glycemia was shown. At day 12 and 20, serum glucose concentrations were significant lower (p < 0.05). From day 12 the insulin dose was reduced to 0.8 IU BID. Insulin was reduced in the following weeks and glycemia was controlled.
authors.affiliation: Department of Veterinary Science, University of Parma, 43100 Parma, Italy.enrico.bigliardi@gmail.com.
authors.forename: Enrico
authors.initials: E
authors.lastname: Bigliardi
authors.forename: Carla
authors.initials: C
authors.lastname: Bresciani
authors.forename: Daniela
authors.initials: D
authors.lastname: Callegari
authors.forename: Francesco
authors.initials: F
authors.lastname: Di Ianni
authors.forename: Giorgio
authors.initials: G
authors.lastname: Morini
authors.forename: Enrico
authors.initials: E
authors.lastname: Parmigiani
authors.forename: Ezio
authors.initials: E
authors.lastname: Bianchi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy* / Q000209:etiology; D004285:Dogs; D004963:Estrenes / Q000627:therapeutic use*; D030762:Estrous Cycle; D005260:Female; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007333:Insulin Resistance; D011247:Pregnancy; D011863:Radioimmunoassay / Q000662:veterinary; D011980:Receptors, Progesterone / Q000037:antagonists & inhibitors*
chemical_list: D001786:Blood Glucose; D004963:Estrenes; D007004:Hypoglycemic Agents; D011980:Receptors, Progesterone; C419063:aglepristone
keywords: aglepristone; bitches; diabetes mellitus; diestrus; insulin resistance