title: Androgenic alopecia is associated with less dietary soy, lower [corrected] blood vanadium and rs1160312 1 polymorphism in Taiwanese communities.
abstract: BACKGROUND
  Although the genetic basis of androgenic alopecia has been clearly established, little is known about its non-genetic causes, such as environmental and lifestyle factors.
  
  
  OBJECTIVE
  This study investigated blood and urine heavy metals concentrations, environmental exposure factors, personal behaviors, dietary intakes and the genotypes of related susceptibility genes in patients with androgenic alopecia (AGA).
  
  
  METHODS
  Age, AGA level, residence area, work hours, sleep patterns, cigarette usage, alcohol consumption, betel nut usage, hair treatments, eating habits, body heavy metals concentrations and rs1998076, rs913063, rs1160312 and rs201571 SNP genotype data were collected from 354 men. Logistic regression analysis was performed to examine whether any of the factors displayed odds ratios (ORs) indicating association with moderate to severe AGA (≥ IV). Subsequently, Hosmer-Lemeshow, Nagelkerke R(2) and accuracy tests were conducted to help establish an optimal model.
  
  
  RESULTS
  Moderate to severe AGA was associated with the AA genotype of rs1160312 (22.50, 95% CI 3.99-126.83), blood vanadium concentration (0.02, 95% CI 0.01-0.04), and regular consumption of soy bean drinks (0.23, 95% CI 0.06-0.85), after adjustment for age. The results were corroborated by the Hosmer-Lemeshow test (P = 0.73), Nagelkerke R(2) (0.59), accuracy test (0.816) and area under the curve (AUC; 0.90, 0.847-0.951) analysis.
  
  
  CONCLUSIONS
  Blood vanadium and frequent soy bean drink consumption may provide protect effects against AGA. Accordingly, blood vanadium concentrations, the AA genotype of rs1160312 and frequent consumption of soy bean drinks are associated with AGA.
authors.affiliation: Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Ching-Huang
authors.initials: CH
authors.lastname: Lai
authors.affiliation: Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan ; Taitung Hospital, Department of Health, Executive Yuan, Taiwan.
authors.forename: Nain-Feng
authors.initials: NF
authors.lastname: Chu
authors.affiliation: School of Nursing, College of Medicine, Chang-Gung University, Taoyuan, Taiwan.
authors.forename: Chi-Wen
authors.initials: CW
authors.lastname: Chang
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, MiaoLi, Taiwan.
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Wang
authors.affiliation: Institute of Statistical Science Academia Sinica, Taipei, Taiwan.
authors.forename: Hsin-Chou
authors.initials: HC
authors.lastname: Yang
authors.affiliation: Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Chu
authors.affiliation: Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chu-Ting
authors.initials: CT
authors.lastname: Chang
authors.affiliation: Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Ming-Huang
authors.initials: MH
authors.lastname: Lin
authors.affiliation: Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Wu-Chien
authors.initials: WC
authors.lastname: Chien
authors.affiliation: Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Sui-Lung
authors.initials: SL
authors.lastname: Su
authors.affiliation: Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Chou
authors.affiliation: School of Nursing, College of Medicine, Chang-Gung University, Taoyuan, Taiwan.
authors.forename: Kang-Hua
authors.initials: KH
authors.lastname: Chen
authors.affiliation: Department of Dermatology, Tri-Service General Hospital, Taipei, Taiwan.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan ; Division of Environmental Health and Occupational Medicine, National Health Research Institutes, MiaoLi, Taiwan.
authors.forename: Saou-Hsing
authors.initials: SH
authors.lastname: Liou
mesh_terms: D000505:Alopecia / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D002890:Chromosomes, Human, Pair 20; D021901:DNA, Intergenic; D004781:Environmental Exposure; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D019216:Metals, Heavy / Q000652:urine; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D030262:Soybean Proteins; D013624:Taiwan / Q000453:epidemiology; D014639:Vanadium / Q000097:blood*
chemical_list: D021901:DNA, Intergenic; D019216:Metals, Heavy; D030262:Soybean Proteins; D014639:Vanadium