title: [A resected case of hilar cholangiocarcinoma treated with neoadjuvant chemoradiation therapy].
abstract: The patient was a 69-year-old woman with elevated levels of hepatobiliary enzymes. An abdominal computed tomography (CT) scan revealed an enhanced mass in the liver hilum with dilatation of the intrahepatic bile duct. We diagnosed hilar cholangiocarcinoma and administered neoadjuvant chemoradiation therapy because of the possibility of tumor cells remaining at the surgical margins. Radical surgery was performed and pathological examination showed the tumor to be Grade 2b according to the Oboshi-Shimosato classification. Although postoperative bile leakage and intra-abdominal abscess were observed, the patient was discharged on day 82 after surgery. The patient is still alive without recurrence at 17 months after the surgery. Neoadjuvant chemoradiation therapy has the potential to obtain a negative surgical margin in patients with hilar cholangiocarcinoma, which is likely to be positive for cancer cells at the surgical margin in preoperative diagnosis.
authors.affiliation: Dept. of Digestive Surgery and Surgical Oncology (Dept. of Surgery II),Yamaguchi University Graduate School of Medicine.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Yamada
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Takao
authors.initials: T
authors.lastname: Tamesa
authors.forename: Hiroto
authors.initials: H
authors.lastname: Matsui
authors.forename: Yoshitaro
authors.initials: Y
authors.lastname: Shindo
authors.forename: Yukio
authors.initials: Y
authors.lastname: Tokumitsu
authors.forename: Noriaki
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Michihisa
authors.initials: M
authors.lastname: Iida
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Maeda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tokuhisa
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Tomio
authors.initials: T
authors.lastname: Ueno
authors.forename: Masataro
authors.initials: M
authors.lastname: Takahashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Shibuya
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kondo
authors.forename: Masaaki
authors.initials: M
authors.lastname: Oka
mesh_terms: D000368:Aged; D001650:Bile Duct Neoplasms / Q000473:pathology / Q000628:therapy*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology / Q000601:surgery*; D059248:Chemoradiotherapy; D018281:Cholangiocarcinoma / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D020360:Neoadjuvant Therapy; D060787:Neoplasm Grading