title: Influence of a variable overall diameter hydrophilic acrylic sharp-edged single-piece intra-ocular lens on capsule opacification one year after surgery.
abstract: BACKGROUND
  To investigate the influence of the overall intraocular lens (IOL) diameter on posterior capsule opacification (PCO) formation.
  
  
  METHODS
  In this prospective randomized clinical trial, 124 eyes of 62 patients with bilateral age-related cataract were included. Each patient received a Corneal A501D IOL in one eye and a Corneal J501D IOL in the fellow eye. Best corrected visual acuity (BCVA) and digital slitlamp photographs were taken a 1 h, 1 week, 1, 3, 6 and 12 months postoperatively. The amount of PCO was assessed subjectively at the slitlamp and objectively using automated image-analysis software.
  
  
  RESULTS
  We found a mean BCVA of 0.81 ± 0.2 for the Corneal A501D group and 0.79 ± 0.21 for the Corneal J501D group. There was no significant difference 12 months after surgery between the two IOLs (p > 0.05). Objective PCO assessment resulted in a mean PCO score (scale 0-10) of 1.65 ± 1.71 was found for the Corneal J501D group and a score of 1.54 ± 1.64 was found for the Corneal A501D group (p > 0.05). The subjective PCO assessment at 1 year resulted in a mean PCO score of 2.0 ± 1.74 in the Corneal J501D group and 2.13 ± 1.64 in the Corneal A501D group (p > 0.05).
  
  
  CONCLUSIONS
  Both investigated IOLs showed good clinical performance regarding PCO and BCVA. Our study suggests that the use of an IOL with variable total diameter seems not to influence the rate of PCO formation.
authors.affiliation: Department of Ophthalmology, Medical University of Vienna , Vienna , Austria.
authors.forename: Georgios
authors.initials: G
authors.lastname: Mylonas
authors.forename: Michael
authors.initials: M
authors.lastname: Georgopoulos
authors.forename: Ana
authors.initials: A
authors.lastname: Prinz
authors.forename: Lorenz
authors.initials: L
authors.lastname: Vock
authors.forename: Robert A
authors.initials: RA
authors.lastname: Blum
authors.forename: Ursula
authors.initials: U
authors.lastname: Schmidt-Erfurth
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D000369:Aged, 80 and over; D058442:Capsule Opacification / Q000175:diagnosis / Q000453:epidemiology* / Q000601:surgery; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015994:Incidence; D053844:Lasers, Solid-State / Q000627:therapeutic use; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D057852:Posterior Capsule of the Lens / Q000473:pathology*; D064727:Posterior Capsulotomy; D011446:Prospective Studies; D011474:Prosthesis Design; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000180:Acrylic Resins