title: 8-nitro-cGMP--a new player in antibacterial autophagy.
abstract: In this issue of Molecular Cell, Ito et al. (2013) identify 8-nitro-cGMP as a new autophagy inducer mediating the clearance of invading bacteria in a mechanism that depends on protein S-guanylation and Lys63-linked ubiquitination. This study reveals an additional link between the innate immune response and autophagy.
authors.affiliation: Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel.
authors.forename: Moran
authors.initials: M
authors.lastname: Rawet-Slobodkin
authors.affiliation: Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel. Electronic address: zvulun.elazar@weizmann.ac.il.
authors.forename: Zvulun
authors.initials: Z
authors.lastname: Elazar
mesh_terms: D000818:Animals; D001343:Autophagy; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000378:metabolism*; D013297:Streptococcus pyogenes / Q000378:metabolism*
chemical_list: C525106:8-nitroguanosine 3',5'-cyclic monophosphate; D006152:Cyclic GMP