title: Interdisciplinary approach for treating a large through-and-through periapical defect using guided tissue regeneration: a case report.
abstract: A number of diagnostic and management challenges exist for achieving complete regeneration of large through-and-through periapical lesions. An unfavorable endodontic outcome may occur as a result of uncontrolled infection or unpredictable bone healing. This article presents a case with a 15 × 15-mm through-and-through periapical lesion and persistent gingival swelling. Endodontic microsurgery and guided tissue regeneration were performed using a resorbable membrane and osseous substitute. A 2-year postoperative radiograph revealed complete resolution of the periapical radiolucency. Seven-year clinical and radiographic follow-up showed that the tooth was asymptomatic and a long-term successful outcome had been maintained.
authors.forename: Guo-Hao
authors.initials: GH
authors.lastname: Lin
authors.forename: Lien-Yu
authors.initials: LY
authors.lastname: Chang
authors.forename: Wen-Chun
authors.initials: WC
authors.lastname: Lin
authors.forename: Shyh-Yuan
authors.initials: SY
authors.lastname: Lee
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Lai
mesh_terms: D000328:Adult; D005882:Gingival Diseases / Q000628:therapy*; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008297:Male; D014092:Tooth Root / Q000473:pathology*; D055815:Young Adult