title: Efficacy of some colloidal silver preparations and silver salts against Proteus bacteria, one possible cause of rheumatoid arthritis.
abstract: There has been increased interest in the role of anti-Proteus antibodies in the aetiology of rheumatoid arthritis (RA) and whether chemotherapeutic agents active against Proteus species might reduce the risk and/or exacerbations of RA. We examined the in vitro antibacterial effects of ten different silver preparations which were either ionic silver [Ag(I)] solutions or nanoparticulate silver (NPS) (Ag(0)) suspensions against ATCC and two wild (clinical) strains of Proteus. The data establish the low minimum inhibitory concentration and minimum bactericidal concentration of all the silver formulations tested against these four Proteus strains. In a pilot study, a potent NPS preparation ex vivo showed long-lasting anti-Proteus activity in a normal human volunteer.
authors.affiliation: Pathology Queensland, Princess Alexandra Hospital, Woolloongabba, Brisbane, QLD, 4102, Australia.
authors.forename: D M B T
authors.initials: DM
authors.lastname: Disaanayake
authors.forename: Joan
authors.initials: J
authors.lastname: Faoagali
authors.forename: Hans
authors.initials: H
authors.lastname: Laroo
authors.forename: Gerald
authors.initials: G
authors.lastname: Hancock
authors.forename: Michael
authors.initials: M
authors.lastname: Whitehouse
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000209:etiology / Q000382:microbiology*; D003102:Colloids / Q000627:therapeutic use*; D006801:Humans; D053768:Metal Nanoparticles / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests / Q000379:methods; D019999:Pharmaceutical Solutions / Q000627:therapeutic use*; D010865:Pilot Projects; D011511:Proteus / Q000187:drug effects*; D012492:Salts / Q000627:therapeutic use*; D012834:Silver / Q000627:therapeutic use*; D013535:Suspensions / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D003102:Colloids; D019999:Pharmaceutical Solutions; D012492:Salts; D013535:Suspensions; D012834:Silver