title: Carbapenemase-producing bacteria in companion animals: a public health concern on the horizon.
abstract: Clinical infections attributed to carbapenemase-producing bacteria are a pressing public health concern owing to limited therapeutic options and linked antimicrobial resistance. In recent years, studies have reported the emergence and spread of carbapenemase-producing Enterobacteriaceae and their public health impact. This has been closely followed by the global dissemination of highly resistant and virulent zooanthroponotic extraintestinal pathogenic Escherichia coli (ExPEC) ST131 clones. It has also been hypothesized that companion animals may act as a reservoir for Gram-negative multidrug-resistant pathogens in the community. Two recent reports have documented the emergence of carbapenemase-producing bacteria in companion animals. This phenomenon is of great concern because of the close contact between humans and their pets, and the potential for cross-species transmission. This scenario suggests a role for multifaceted control of Gram-negative multidrug-resistant infections in companion animals. This short article addresses this issue and identifies steps that could facilitate this process.
authors.affiliation: School of Animal and Veterinary Sciences, University of Adelaide, South Australia 5371, Australia.
authors.forename: Sam
authors.initials: S
authors.lastname: Abraham
authors.forename: Hui San
authors.initials: HS
authors.lastname: Wong
authors.forename: John
authors.initials: J
authors.lastname: Turnidge
authors.forename: James R
authors.initials: JR
authors.lastname: Johnson
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Trott
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D024881:Drug Resistance, Bacterial; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000635:transmission / Q000662:veterinary*; D006801:Humans; D057805:Pets / Q000382:microbiology*; D011634:Public Health; D018570:Risk Assessment; D015047:Zoonoses / Q000635:transmission*; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D001618:beta-Lactamases; C063912:carbapenemase
keywords: Escherichia coli; NDM-1; OXA-48; ST131; UTIs; antibiotic resistance; urinary tract infections