title: High-field small animal magnetic resonance oncology studies.
abstract: This review focuses on the applications of high magnetic field magnetic resonance imaging (MRI) and spectroscopy (MRS) to cancer studies in small animals. High-field MRI can provide information about tumor physiology, the microenvironment, metabolism, vascularity and cellularity. Such studies are invaluable for understanding tumor growth and proliferation, response to treatment and drug development. The MR techniques reviewed here include (1)H, (31)P, chemical exchange saturation transfer imaging and hyperpolarized (13)C MRS as well as diffusion-weighted, blood oxygen level dependent contrast imaging and dynamic contrast-enhanced MRI. These methods have been proven effective in animal studies and are highly relevant to human clinical studies.
authors.affiliation: Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, 415 East 68 Street, New York, NY 10065, USA.
authors.forename: Louisa
authors.initials: L
authors.lastname: Bokacheva
authors.forename: Ellen
authors.initials: E
authors.lastname: Ackerstaff
authors.forename: H Carl
authors.initials: HC
authors.lastname: LeKaye
authors.forename: Kristen
authors.initials: K
authors.lastname: Zakian
authors.forename: Jason A
authors.initials: JA
authors.lastname: Koutcher
mesh_terms: D000818:Animals; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009369:Neoplasms / Q000097:blood / Q000175:diagnosis*; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen