title: Role of postmastectomy radiation therapy after neoadjuvant chemotherapy in locally advanced breast cancer.
abstract: Neoadjuvant chemotherapy for primary breast cancer is the gold standard in the treatment of locally advanced, inoperable breast cancer, and also based on a large body of evidence has become a standard treatment option for patients with operable disease, who are clear candidates for adjuvant chemotherapy. There are several advantages of administering neoadjuvant chemotherapy: tumor downstaging, improving the chance of breast conserving surgery, in vivo assessment of tumor sensitivity to the chosen therapeutic regimen, and early control of micro-metastatic disease. However there are substantially less data to aid in determining which patients treated with neo-adjuvant chemotherapy warrant postmastectomy radiotherapy. According to the recent literature, patients who require mastectomy after systemic therapy should receive postmastectomy radiotherapy.
authors.affiliation: Department of Radiation Oncology, Ankara University, Ankara 06590, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Akyurek
authors.affiliation: Department of Radiation Oncology, Faculty of Medicine, Selcuk University, Konya 42075 Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Yavas
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008408:Mastectomy; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011182:Postoperative Care; D011878:Radiotherapy / Q000379:methods; D016896:Treatment Outcome