title: Human Immunodeficiency Virus (HIV)-Negative and Human Herpes Virus-8 (HHV-8)-Positive Primary Effusion Lymphoma: A Case Report and Review of the Literature.
abstract: Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma that presents with serosal effusion in body cavities, without obvious tumor masses. Although PEL occurs in immunocompromised patients that are human immunodeficiency virus (HIV) positive, it also occurs in immunocompetent human herpes virus-8 (HHV-8)-positive patients. Herein we present an immunocompetent, HIV-negative, CD-20-negative, HHV-8-positive patient with pleural effusion that was diagnosed as PEL. The CHOP protocol and talc pleurodesis were administered. HHV-8 plays a causative role in PEL and is important for differentiating PEL from other types of lymphoma. As such, in addition to pleurodesis antiviral treatment should be considered for optimal treatment outcome.
  
  
  BACKGROUND
  None declared.
authors.affiliation: Turgut Özal University, School of Medicine, Department of Internal Medicine, Ankara, Turkey.
authors.forename: Sonay
authors.initials: S
authors.lastname: Güven Karataş
authors.affiliation: Turgut Özal University, School of Medicine, Department of Pathology, Ankara, Turkey.
authors.forename: Reyhan
authors.initials: R
authors.lastname: Bayrak
authors.affiliation: Turgut Özal University, School of Medicine, Department of Hematology, Ankara, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Sahin Balçık
authors.affiliation: Turgut Özal University, School of Medicine, Department of Internal Medicine, Ankara, Turkey.
authors.forename: Kadir Serkan
authors.initials: KS
authors.lastname: Yalçın
authors.affiliation: Turgut Özal University, School of Medicine, Department of Internal Medicine, Ankara, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Atıcı
authors.affiliation: Turgut Özal University, School of Medicine, Department of Internal Medicine, Ankara, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Akyıldız
authors.affiliation: Turgut Özal University, School of Medicine, Department of Hematology, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Koşar
keywords: Differential diagnosis; Human herpes virus-8; Human immunodeficiency virus (HIV); Pleural effusion; Primary effusion lymphoma