title: Ubiquitin in the immune system.
abstract: Ubiquitination is a post-translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune response by ensuring the proper functioning of the different cell types that constitute the immune system. Here, we provide an overview of the latest discoveries in this field and discuss how they impact our understanding of the ubiquitin system in host defence mechanisms as well as self-tolerance.
authors.affiliation: Centre for Cell Death, Cancer, and Inflammation (CCCI) UCL Cancer Institute, University College London, London, UK.
authors.forename: Julia
authors.initials: J
authors.lastname: Zinngrebe
authors.forename: Antonella
authors.initials: A
authors.lastname: Montinaro
authors.forename: Nieves
authors.initials: N
authors.lastname: Peltzer
authors.forename: Henning
authors.initials: H
authors.lastname: Walczak
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology; D000818:Animals; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D059748:Proteolysis; D017634:Self Tolerance; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D025801:Ubiquitin / Q000502:physiology*; D054875:Ubiquitination
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D051193:Toll-Like Receptors; D014409:Tumor Necrosis Factor-alpha; D025801:Ubiquitin