title: Bisphenol A (BPA) and its potential role in the pathogenesis of the polycystic ovary syndrome (PCOS).
abstract: Polycystic ovary syndrome (PCOS) is the most common and the most heterogeneous endocrine disorder in premenopausal women. Apart from signs of hyperandrogenism such as acne, hirsutism and hair loss, women with PCOS usually present with menstrual irregularities and fertility problems.Additionally, they are often characterized by impaired glucose tolerance, which usually leads to the development of type 2 diabetes mellitus (T2DM). This review article describes current and novel approach to the pathomechanisms of PCOS and the potential role of an endocrine disrupting chemical ("endocrine disruptor" - ED) - bisphenol A (BPA), which is commonly used as a plasticizer and due to its molecular structure can interact with estrogen receptors (ERs). Recent observations point to the higher levels of BPA in biological fluids of women with PCOS and its role in the pathogenesis of hyperandrogenism and hyperinsulinemia. It seems that mother's exposure to BPA during pregnancy may also lead to the development of PCOS in the female offspring.
authors.affiliation: Department of Clinical and Experimental Endocrinology, Institute of Maritime and Tropical Medicine, Medical University of Gdańsk , Gdynia , Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Rutkowska
authors.forename: Dominik
authors.initials: D
authors.lastname: Rachoń
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000506:poisoning* / Q000633:toxicity; D052244:Endocrine Disruptors / Q000506:poisoning* / Q000633:toxicity; D005260:Female; D006801:Humans; D010636:Phenols / Q000506:poisoning* / Q000633:toxicity; D011085:Polycystic Ovary Syndrome / Q000139:chemically induced* / Q000473:pathology; D011247:Pregnancy; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds