title: Novel and predominant pathogen responsible for the enterovirus-associated encephalitis in eastern China.
abstract: Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates from this study belonged to the human EV B (HEV B) family and were distributed in three clusters.
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R.China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P.R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
authors.affiliation: Health Sciences Research Institute and School of Natural Sciences, University of California, Merced, Merced, California, United States of America.
authors.forename: David M
authors.initials: DM
authors.lastname: Ojcius
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R.China.
authors.forename: Huakun
authors.initials: H
authors.lastname: Lv
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R.China.
authors.forename: Ziping
authors.initials: Z
authors.lastname: Miao
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R.China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R.China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, P.R.China.
authors.forename: Jvying
authors.initials: J
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D018792:Encephalitis, Viral / Q000453:epidemiology / Q000235:genetics / Q000821:virology; D004770:Enterovirus / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies