title: [A case of facial nerve palsy induced by nab-paclitaxel].
abstract: The patient was a 60-year-old woman who underwent total mastectomy and axillary lymph node dissection for right breast cancer. She was treated with adjuvant chemotherapy( epirubicin plus cyclophosphamide[EC]and paclitaxel), hormone therapy, and radiation therapy. Multiple lung, lymph node, and bone metastases were detected after 4 years. The patient subsequently received nab-paclitaxel (nabPTX, 260 mg/m2, triweekly) and zoledronate therapy. Ptosis of her right eyebrow and the right angle of her mouth were observed after 8 courses of nabPTX, and peripheral right facial nerve palsy was diagnosed. She underwent rehabilitation, and facial nerve palsy improved after 9 months. Peripheral facial nerve palsy is a very rare adverse event of nabPTX. This is the first case report of peripheral facial nerve paralysis associated with nab- PTX.
authors.affiliation: Dept. of Surgery, Kitasato University School of Medicine.
authors.forename: Naoko
authors.initials: N
authors.lastname: Minatani
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Kosaka
authors.forename: Norihiko
authors.initials: N
authors.lastname: Sengoku
authors.forename: Mariko
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishimiya
authors.forename: Mina
authors.initials: M
authors.lastname: Waraya
authors.forename: Takumo
authors.initials: T
authors.lastname: Enomoto
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Tanino
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000418:Albumins / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy; D004164:Diphosphonates / Q000008:administration & dosage; D005158:Facial Paralysis / Q000139:chemically induced* / Q000534:rehabilitation; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects*; D000077211:Zoledronic Acid
chemical_list: C520255:130-nm albumin-bound paclitaxel; D000418:Albumins; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D017239:Paclitaxel