title: Mechanical properties of morcellised bone graft with the addition of hydroxyapatite.
abstract: Mixtures of morcellised bone graft (MBG) and hydroxyapatite (HA) are frequently used in revision arthroplasty surgery. However, the changes in the mechanical properties from adding HA to MBG are unknown. This study used a uniaxial compression test to replicate impaction bone grafting and subsequent early postoperative weightbearing to investigate the effect of adding different proportion of HA to MBG. To achieve this aim, human MBG was subjected to increasing impaction forces and the apparent stiffness and creep for each stress level determined. Subsequently, increasing proportions porous and non porous HA were added to the MBG. The major findings were that the apparent stiffness for MBG increased and the associated creep decreased both with the application of increasing stress and with the addition of increasing proportions of HA. In conclusion, greater proportions of HA in the graft mixture improved the mechanical response compared with MBG impacted under the same force. This improvement replicated the properties of pure MBG under high axial stress. This study indicates that graft mixtures of MBG and HA can be tailormade for patients. The need for less impaction force in MBG:HA mixtures to obtain the same properties as pure MBG may decrease the risk of intraoperative fracture.
authors.affiliation: Norfolk and Norwich University Hospital NHS foundation trust, Norwich, NR4 7UY, UK, imcnamara@doctors.org.uk.
authors.forename: I
authors.initials: I
authors.lastname: McNamara
authors.forename: J
authors.initials: J
authors.lastname: Howard
authors.forename: A
authors.initials: A
authors.lastname: Rayment
authors.forename: R
authors.initials: R
authors.lastname: Schalk
authors.forename: R
authors.initials: R
authors.lastname: Brooks
authors.forename: S
authors.initials: S
authors.lastname: Best
authors.forename: N
authors.initials: N
authors.lastname: Rushton
mesh_terms: D001672:Biocompatible Materials; D018786:Bone Substitutes; D045424:Complex Mixtures; D017886:Durapatite; D006801:Humans; D008422:Materials Testing
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D045424:Complex Mixtures; D017886:Durapatite