title: Cardioprotective effect of root extract of Picrorhiza kurroa (Royle Ex Benth) against isoproterenol-induced cardiotoxicity in rats.
abstract: Normal rats pre-treated with P. kurroa (200 mg/kg) alone did not showed significant change, however, isoproterenol (ISP) administration resulted in hemodynamic and left ventricular dysfunction, oxidative stress, and lipid peroxidation. Such cardiac dysfunction was significantly prevented by P. kurroa root extract pre-treatment. Pre-treatment significantly attenuated the ISP-induced oxidative stress by restoring myocardial superoxide dismutase, catalase, and glutathione peroxidase enzymes except reduced glutathione content. P. kurroa pre-treatment markedly attenuated the ISP-induced rise in lipid peroxidation, thereby prevented leakage of myocyte creatine kinase-MB and lactate dehydrogenase enzymes. The results suggest that P. kurroa root extract possesses significant cardioprotective effect, which may be attributed to its antioxidant, anti-peroxidative, and myocardial preservative properties.
authors.affiliation: SPP School of Pharmacy & Technology Management, SVKM'S NMIMS, Mithibai College Building, Vile Parle (West), Mumbai 400 056, India. mukeshnandave@gmail.com
authors.forename: Mukesh
authors.initials: M
authors.lastname: Nandave
authors.affiliation: Cardiovascular Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029, India.
authors.forename: Shreesh Kumar
authors.initials: SK
authors.lastname: Ojha
authors.affiliation: Division of Plant Physiology, Indian Agriculture Research Institute (IARI), New Delhi 110 016, India.
authors.forename: Santosh
authors.initials: S
authors.lastname: Kumari
authors.affiliation: Department of Anatomy, All India Institute of Medical Sciences, New Delhi 110 029, India.
authors.forename: Tapas Chandra
authors.initials: TC
authors.lastname: Nag
authors.affiliation: Department of Anatomy, All India Institute of Medical Sciences, New Delhi 110 029, India.
authors.forename: Raj
authors.initials: R
authors.lastname: Mehra
authors.affiliation: Department of Cardiology, All India Institute of Medical Sciences, New Delhi 110 029, India.
authors.forename: Rajiv
authors.initials: R
authors.lastname: Narang
authors.affiliation: Cardiovascular Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110 029, India.
authors.forename: Dharamvir Singh
authors.initials: DS
authors.lastname: Arya
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D010943:Plantago / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002316:Cardiotonic Agents; D010936:Plant Extracts