title: Collagen fleece failed to prevent intrapleural adhesions in a canine model: failure of murine models to translate into a large animal model.
abstract: Intrapleural and anti-adhesive materials were investigated in murine models, but not in a large animal model before clinical application. Our results failed to show any anti-adhesion effect of collagen fleece and suggested the thoracic physiology in murine models would not translate into a large animal model.
authors.affiliation: Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, mhamaji@kuhp.kyoto-u.ac.jp.
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hamaji
authors.forename: Fumitsugu
authors.initials: F
authors.lastname: Kojima
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage*; D004285:Dogs; D004338:Drug Combinations; D005340:Fibrinogen / Q000008:administration & dosage*; D006490:Hemostatics / Q000008:administration & dosage*; D051379:Mice; D023421:Models, Animal; D035422:Pleural Cavity; D013917:Thrombin / Q000008:administration & dosage*; D000267:Tissue Adhesions / Q000517:prevention & control*
chemical_list: D004338:Drug Combinations; D006490:Hemostatics; C093991:tachocomb; D005340:Fibrinogen; D007611:Aprotinin; D013917:Thrombin