title: GM3 and diabetes.
abstract: We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides". It is expected that the development of novel diagnosis of metabolic syndrome by identifying the specific ganglioside species and a therapeutic strategy "membrane microdomain ortho-signaling therapy".
authors.affiliation: Division of Glycopathology, Institute of Molecular Biomembranes and Glycobiology, Tohoku Pharmaceutical University, 4-4-1, komatsushima, Aoba-ku, Sendai, 981-8558, Miyagi, Japan, jin@tohoku-pharm.ac.jp.
authors.forename: Jin-ichi
authors.initials: J
authors.lastname: Inokuchi
mesh_terms: D000595:Amino Acid Sequence; D015415:Biomarkers / Q000097:blood*; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000503:physiopathology; D005679:G(M3) Ganglioside / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000097:blood*; D008969:Molecular Sequence Data
chemical_list: D015415:Biomarkers; D005679:G(M3) Ganglioside