title: A case of pachydermoperiostosis associated with arthritis.
abstract: Abstract Pachydermoperiostosis (PDP) is characterized by clubbing fingers, furrowing of the facial skin, and perio-steal hypertrophy. We report a case of a patient with PDP associated with severe arthritis of the knee and ankle joints. His serum C-reactive protein (CRP) levels were increased, and an analysis of serum and synovial fluid showed high levels of interleukin-6. These findings mean that there is some difficulty in distinguishing the disease from rheumatoid arthritis. While treatments such as nonsteroidal anti-inflammatory drugs, steroids, and colchicine were not particularly effective, the severe arthralgia was gradually relieved over a few years.
authors.affiliation: Department of Orthopedic Surgery, School of Medicine, Nagasaki University , 1-7-1 Sakamoto, Nagasaki 852-8501 , Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tsurumoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shindo