title: Clinical and ethical implications of mitochondrial gene transfer.
abstract: Inherited diseases caused by mitochondrial gene (mtDNA) mutations affect at least 1 in 5000-10,000 children and are associated with severe clinical symptoms. Novel reproductive techniques designed to replace mutated mtDNA in oocytes or early embryos have been proposed to prevent transmission of disease from parents to their children. Here we review the efficacy and safety of these approaches and their associated ethical and regulatory issues.
authors.affiliation: Oregon National Primate Research Center, Oregon Health and Science University, 505 North West 185th Avenue, Beaverton, OR 97006, USA. Electronic address: mitalipo@ohsu.edu.
authors.forename: Shoukhrat
authors.initials: S
authors.lastname: Mitalipov
authors.affiliation: Oregon National Primate Research Center, Oregon Health and Science University, 505 North West 185th Avenue, Beaverton, OR 97006, USA.
authors.forename: Don P
authors.initials: DP
authors.lastname: Wolf
mesh_terms: D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D050259:Genes, Mitochondrial; D015316:Genetic Therapy / Q000941:ethics* / Q000331:legislation & jurisprudence; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000235:genetics; D028361:Mitochondrial Diseases / Q000235:genetics* / Q000517:prevention & control*; D009154:Mutation; D053652:Nuclear Transfer Techniques / Q000941:ethics* / Q000331:legislation & jurisprudence; D009865:Oocytes; D027724:Reproductive Techniques, Assisted / Q000941:ethics / Q000331:legislation & jurisprudence; D006113:United Kingdom; D014481:United States
chemical_list: D004272:DNA, Mitochondrial
keywords: assisted reproductive technologies; mtDNA mutations