title: Changes in serum BDNF levels associated with moderate-intensity exercise in healthy young Japanese men.
abstract: OBJECTIVE
  The purpose of this study was to examine the influence of acute moderate-intensity exercise on serum brain-derived neurotrophic factor (BDNF) levels in healthy young Japanese men. BDNF is one of a family of neurotrophic factors involved in neuronal transmission, modulation and plasticity. Previous human-based studies have demonstrated that acute exercise leads to increases in BDNF; however, to date there has been no study conducted among Japanese male subjects.
  
  
  METHODS
  Forty young adult Japanese men (aged 24.1 ± 2.9 years) - reduced to a total of thirty three following subjection to exclusion criteria - performed 30 minutes of exercise at 60% of VO2max on a stationary bicycle. Serum BDNF was analyzed both before and after exercise.
  
  
  RESULTS
  Eighteen of the total thirty three subjects demonstrated an increase in serum BDNF after exercise. However, on aggregate, the change in serum BDNF associated with exercise was not significant (p = .17).
  
  
  CONCLUSIONS
  This is the first study to demonstrate that serum BDNF levels are not consistently increased by acute moderate-intensity exercise in Japanese men. It is likely that something in the lifestyle and/or environment of male Japanese subjects underlies the difference between our findings and studies conducted in other countries.
authors.affiliation: Johns Hopkins School of Medicine, Center for Surgical Trials and Outcomes Research, 600 N. Wolfe Street, Baltimore, MD 21205 USA.
authors.forename: Akio
authors.initials: A
authors.lastname: Goda
authors.affiliation: Johns Hopkins School of Medicine, Center for Surgical Trials and Outcomes Research, 600 N. Wolfe Street, Baltimore, MD 21205 USA.
authors.forename: Shohei
authors.initials: S
authors.lastname: Ohgi
authors.affiliation: Johns Hopkins School of Medicine, Center for Surgical Trials and Outcomes Research, 600 N. Wolfe Street, Baltimore, MD 21205 USA.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kinpara
authors.affiliation: Department of healthcare, Kansai University of Health and welfare science, 3-11-1, Asahigaoka, Kashiwara-City, Osaka, 582-0026 Japan.
authors.forename: Kenta
authors.initials: K
authors.lastname: Shigemori
authors.affiliation: Department of Rehabilitation, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka, 589-8511 Japan.
authors.forename: Kanji
authors.initials: K
authors.lastname: Fukuda
authors.affiliation: Johns Hopkins School of Medicine, Center for Surgical Trials and Outcomes Research, 600 N. Wolfe Street, Baltimore, MD 21205 USA.
authors.forename: Eric B
authors.initials: EB
authors.lastname: Schneider
keywords: Aerobic exercise; Brain-derived neurotrophic factor; Human; Japanese; Physical activity