title: Practical synthesis of kainoids: a new chemical probe precursor and a fluorescent probe.
abstract: A practical total synthesis of kainoid MFPA (5) was achieved in only six steps, via a novel Ni-catalyst-mediated asymmetric conjugate addition reaction. Furthermore, a fluorescein-based fluorescent ionotropic glutamate receptor probe 28 was efficiently synthesized from a precursor derived from a synthetic intermediate of 5.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka , 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
authors.forename: Shingo
authors.initials: S
authors.lastname: Sasaki
authors.forename: Hiroto
authors.initials: H
authors.lastname: Suzuki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ouchi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Asakawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Inai
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Sakai
authors.forename: Keiko
authors.initials: K
authors.lastname: Shimamoto
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Hamashima
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kan
mesh_terms: D002384:Catalysis; D019793:Fluorescein / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D007608:Kainic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D005456:Fluorescent Dyes; D007608:Kainic Acid; D019793:Fluorescein