title: Risk prediction of hepatitis B virus-related hepatocellular carcinoma in the era of antiviral therapy.
abstract: Hepatocellular carcinoma (HCC) is a grave primary liver cancer that has a limited therapeutic option because it is generally diagnosed later in an advanced stage due to its aggressive biologic behavior. The early detection of HCC has a great impact on the treatment efficacy and survival of patients at high risk for cancer. Potential host, environmental, and virus-related risk factors have been introduced. Hepatitis B virus (HBV) is a major cause of end-stage liver diseases such as liver cirrhosis or HCC in endemic areas, and its serologic or virologic status is considered an important risk factor. HCC risk prediction derived from the identification of major risk factors is necessary for providing adequate screening/surveillance strategies to high-risk individuals. Several risk prediction models for HBV-related HCC have been presented recently with simple, efficient, and readily available to use parameters applicable to average- or unknown-risk populations as well as high-risk individuals. Predictive scoring systems of risk estimation to assess HCC development can provide the way to an evidence-based clinical approach for cost- and effort-effective outcomes, capable of inducing a personalized surveillance program according to risk stratification. In this review, the concepts and perspectives of the risk prediction of HCC are discussed through the analysis of several risk prediction models of HBV-related HCC.
authors.affiliation: Il Han Song, Young Kwang Choo, Division of Hepatology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan 330-715, South Korea.
authors.forename: Il Han
authors.initials: IH
authors.lastname: Song
authors.affiliation: Il Han Song, Young Kwang Choo, Division of Hepatology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan 330-715, South Korea.
authors.forename: So Mi
authors.initials: SM
authors.lastname: Kim
authors.affiliation: Il Han Song, Young Kwang Choo, Division of Hepatology, Department of Internal Medicine, Dankook University College of Medicine, Cheonan 330-715, South Korea.
authors.forename: Young Kwang
authors.initials: YK
authors.lastname: Choo
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control* / Q000821:virology; D003661:Decision Support Techniques; D006509:Hepatitis B / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000517:prevention & control* / Q000821:virology; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents
keywords: Chronic hepatitis B; Hepatitis B virus; Hepatocellular carcinoma; Risk factors; Risk prediction