title: Hypertension, inflammation and T lymphocytes are increased in a rat model of HELLP syndrome.
abstract: OBJECTIVE
  An animal model of hemolysis, elevated liver enzymes, low platelet count (HELLP) was used to determine if T lymphocytes accompany hypertension and increased inflammatory cytokines.
  
  
  METHODS
  sFlt-1 (4.7 µg/kg/day) and sEndoglin (7 µg/kg/day) were infused into normal pregnant rats (HELLP rats) for 8 days.
  
  
  RESULTS
  HELLP was associated with increased mean arterial pressure (p = 0.0001), hemolysis (p = 0.044), elevated liver enzymes (p = 0.027), and reduced platelets (p = 0.035). HELLP rats had increased plasma levels of TNFα (p = 0.039), IL-6 (p = 0.038) and IL-17 (p = 0.04). CD4(+) and CD8(+) T lymphocytes were increased.
  
  
  CONCLUSIONS
  These data support the hypothesis that T cells are associated with hypertension and inflammation.
authors.affiliation: Department of Obstetrics & Gynecology .
authors.forename: Kedra
authors.initials: K
authors.lastname: Wallace
authors.forename: Rachael
authors.initials: R
authors.lastname: Morris
authors.forename: Patrick B
authors.initials: PB
authors.lastname: Kyle
authors.forename: Denise
authors.initials: D
authors.lastname: Cornelius
authors.forename: Marie
authors.initials: M
authors.lastname: Darby
authors.forename: Jeremy
authors.initials: J
authors.lastname: Scott
authors.forename: Janae
authors.initials: J
authors.lastname: Moseley
authors.forename: Krystal
authors.initials: K
authors.lastname: Chatman
authors.forename: Babbette
authors.initials: B
authors.lastname: Lamarca
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004195:Disease Models, Animal; D000071063:Endoglin; D005260:Female; D017359:HELLP Syndrome / Q000097:blood / Q000139:chemically induced / Q000276:immunology* / Q000503:physiopathology; D020381:Interleukin-17 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D047908:Intracellular Signaling Peptides and Proteins; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D018417:Th1 Cells / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D040281:Vascular Endothelial Growth Factor Receptor-1
chemical_list: D000071063:Endoglin; C501740:Eng protein, rat; D020381:Interleukin-17; D015850:Interleukin-6; D047908:Intracellular Signaling Peptides and Proteins; D014409:Tumor Necrosis Factor-alpha; D040281:Vascular Endothelial Growth Factor Receptor-1