title: Serum lipids of castrated rats given hormonal replacement and fed diets with added soybean oil or palm oil.
abstract: The effects of castration with/ without testosterone replacement in male rats, and ovarectomy with oestrogen replacement in female rats, on serum lipids were studied. Simultaneous feeding with diets fortified with 20% weight/ weight (w/ w) soybean oil (Sb) or palm oil (P0) were done to determine the influence of these oils on serum lipids in castrated and sex hormone replaced rats. Two month old male and female Rattus norwegicus rats were given the above treatment for 4 months, and their sera assayed for lipid profile. Castration increased HDL-cholesterol (HDLchol) and total cholesterol (Tchol) concentrations. Testosterone or oestrogen replacement in male and female rats respectively increased HDLchol and decreased LDL-cholesterol (LDLchol) concentrations. Testosterone replacement also decreased Tchol concentration back to noncastrated levels, and reduced serum triglycerides (TG) to lower than non-castrated levels. Addition of Sb or P0 to the diet increased the LDLchol in the testosterone or oestrogen replaced male and female rats, but there was no difference between the two groups. P0 raised serum TG of the testosterone replaced group compared to control and Sb groups. In conclusion, testosterone and oestrogen were found to have favourable effects on serum lipids. Sb and P0 did not differ in their effects on lipoprotein cholesterol and Tchol, but P0 raised serum TG as compared to Sb.
authors.affiliation: Departments of: Pharmacology, Pathology and Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur.
authors.forename: S
authors.initials: S
authors.lastname: Ima-Nirwana
authors.forename: M
authors.initials: M
authors.lastname: Jamaludin
authors.forename: B A
authors.initials: BA
authors.lastname: Khalid
authors.forename: Z
authors.initials: Z
authors.lastname: Merican
authors.forename: S
authors.initials: S
authors.lastname: Baharom