title: Roux-en-Y gastric bypass increases intravenous ethanol self-administration in dietary obese rats.
abstract: Roux-en-Y gastric bypass surgery (RYGB) is an effective treatment for severe obesity. Clinical studies however have reported susceptibility to increased alcohol use after RYGB, and preclinical studies have shown increased alcohol intake in obese rats after RYGB. This could reflect a direct enhancement of alcohol's rewarding effects in the brain or an indirect effect due to increased alcohol absorption after RGYB. To rule out the contribution that changes in alcohol absorption have on its rewarding effects, here we assessed the effects of RYGB on intravenously (IV) administered ethanol (1%). For this purpose, high fat (60% kcal from fat) diet-induced obese male Sprague Dawley rats were tested ~2 months after RYGB or sham surgery (SHAM) using both fixed and progressive ratio schedules of reinforcement to evaluate if RGYB modified the reinforcing effects of IV ethanol. Compared to SHAM, RYGB rats made significantly more active spout responses to earn IV ethanol during the fixed ratio schedule, and achieved higher breakpoints during the progressive ratio schedule. Although additional studies are needed, our results provide preliminary evidence that RYGB increases the rewarding effects of alcohol independent of its effects on alcohol absorption.
authors.affiliation: Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America.
authors.forename: James E
authors.initials: JE
authors.lastname: Polston
authors.affiliation: Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America.
authors.forename: Carolyn E
authors.initials: CE
authors.lastname: Pritchett
authors.affiliation: Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Tomasko
authors.affiliation: Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America.
authors.forename: Ann M
authors.initials: AM
authors.lastname: Rogers
authors.affiliation: Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism (NIAAA), NIH, Bethesda, Maryland, United States of America ; Intramural Research Program, National Institute on Drug Abuse (NIDA), NIH, Baltimore, Maryland, United States of America ; Department of Behavioral and Social Sciences, Brown University, Providence, Rhode Island, United States of America.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Leggio
authors.affiliation: Department of Psychology, Stony Brook University, Stony Brook, New York, United States of America.
authors.forename: Panayotis K
authors.initials: PK
authors.lastname: Thanos
authors.affiliation: Laboratory of Neuroimaging, NIAAA Intramural Program, NIH, Bethesda, Maryland, United States of America.
authors.forename: Nora D
authors.initials: ND
authors.lastname: Volkow
authors.affiliation: Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America ; Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America.
authors.forename: Andras
authors.initials: A
authors.lastname: Hajnal
mesh_terms: D061605:Administration, Intravenous; D000428:Alcohol Drinking / Q000009:adverse effects*; D019973:Alcohol-Related Disorders / Q000209:etiology* / Q000503:physiopathology; D000818:Animals; D001835:Body Weight / Q000502:physiology; D002492:Central Nervous System Depressants / Q000008:administration & dosage* / Q000494:pharmacology; D059305:Diet, High-Fat / Q000009:adverse effects; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D015390:Gastric Bypass / Q000009:adverse effects*; D008297:Male; D009765:Obesity / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012646:Self Administration
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol