title: [Evaluation of manganese-trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetate complex (Cyclomang) as paramagnetic contrast agent for magnetic resonance imaging].
abstract: Preclinical evaluation of a 0.5 M solution of the manganese(II)- trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetate complex (Mn-DCTA, Cyclomang) has been carried out with a view to substitution of potentially toxic gadolinium-containing paramagnetic contrast agents for clinical MRI routines. The toxicological tests of Mn(II)-DCTA were performed on mice and rats. Liquid phantoms were used for evaluating the relaxivity of Mn(II)-DCTA in comparison to that of Gd(III)-DTPA and Mn-DTPA. The diagnostic imaging properties of Mn(II)-DCTA were quantitatively assessed on dogs with cerebral meningeomas (n = 10). The LD50 upon single administration in rats was above 17 ml/kg, thus slightly exceeding the corresponding values for of Gd(III)-DTPA and Mn-DTPA. The relaxivity of Mn(II)-DCTA amounted to R1 = 3.68 (mM(-1) x s(-1)) and did not differ significantly from the values known for Gd-DTPA and Mn-DTPA. Mn(II)-DCTA ensured high-intensity contrast of tumor areas in brain of dogs. It is concluded that Mn(II)-DCTA can be employed as a paramagnetic contrast agent in routine MRI studies and is worth further clinical evaluation.
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Usov
authors.forename: M L
authors.initials: ML
authors.lastname: Balianin
authors.forename: A I
authors.initials: AI
authors.lastname: Bezlepkin
authors.forename: A A
authors.initials: AA
authors.lastname: Churin
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Dubskaia
authors.forename: T L
authors.initials: TL
authors.lastname: Vetoshkina
authors.forename: V D
authors.initials: VD
authors.lastname: Filimonov
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology*; D003287:Contrast Media / Q000493:pharmacokinetics / Q000494:pharmacology; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D007928:Lethal Dose 50; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology; D051379:Mice; D051381:Rats; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; C005390:CDTA; D004492:Edetic Acid