title: The genetics of gene expression in complex mouse crosses as a tool to study the molecular underpinnings of behavior traits.
abstract: Complex Mus musculus crosses provide increased resolution to examine the relationships between gene expression and behavior. While the advantages are clear, there are numerous analytical and technological concerns that arise from the increased genetic complexity that must be considered. Each of these issues is discussed, providing an initial framework for complex cross study design and planning.
authors.affiliation: Portland Alcohol Research Center, Veterans Affairs Medical Center, Portland, 97239, OR, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Hitzemann
authors.forename: Daniel
authors.initials: D
authors.lastname: Bottomly
authors.forename: Ovidiu
authors.initials: O
authors.lastname: Iancu
authors.forename: Kari
authors.initials: K
authors.lastname: Buck
authors.forename: Beth
authors.initials: B
authors.lastname: Wilmot
authors.forename: Michael
authors.initials: M
authors.lastname: Mooney
authors.forename: Robert
authors.initials: R
authors.lastname: Searles
authors.forename: Christina
authors.initials: C
authors.lastname: Zheng
authors.forename: John
authors.initials: J
authors.lastname: Belknap
authors.forename: John
authors.initials: J
authors.lastname: Crabbe
authors.forename: Shannon
authors.initials: S
authors.lastname: McWeeney
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D015870:Gene Expression; D005824:Genetics, Behavioral; D005828:Genetics, Population; D023281:Genomics / Q000379:methods; D051379:Mice; D010641:Phenotype; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable