title: Proteomic profiling of lymphocytes in autoimmunity, inflammation and cancer.
abstract: Lymphocytes play important roles in the balance between body defense and noxious agents involved in a number of diseases, e.g. autoimmune diseases, allergic inflammation and cancer. The proteomic analyses have been applied to identify and validate disease-associated and disease-specific biomarkers for therapeutic strategies of diseases. The proteomic profiles of lymphocytes may provide more information to understand their functions and roles in the development of diseases, although proteomic approaches in lymphocytes are still limited. The present review overviewed the proteomics-based studies on lymphocytes to headlight the proteomic profiles of lymphocytes in diseases, such as autoimmune diseases, allergic inflammation and cancer, with a special focus on lung diseases. We will explore the potential significance of diagnostic biomarkers and therapeutic targets from the current status in proteomic studies of lymphocytes and discuss the value of the currently available proteomic methodologies in the lymphocytes research.
authors.forename: Jiebai
authors.initials: J
authors.lastname: Zhou
authors.forename: Zhitu
authors.initials: Z
authors.lastname: Zhu
authors.forename: Chunxue
authors.initials: C
authors.lastname: Bai
authors.affiliation: Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai Medical College, Shanghai, China. hongzhisun@hotmail.com.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Sun
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D015551:Autoimmunity; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008171:Lung Diseases / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*