title: Implications of the Incidental Finding of a MYCN Amplified Adrenal Tumor: A Case Report and Update of a Pediatric Disease Diagnosed in Adults.
abstract: MYCN is a well-known oncogene overexpressed in different human malignancies including neuroblastoma, rhabdomyosarcoma, medulloblastoma, astrocytoma, Wilms' tumor, and small cell lung cancer. While neuroblastoma is one of the most common childhood malignancies, in adults it is extremely rare and its treatment is based on pediatric protocols that take into consideration stage and genotypic features, such as MYCN amplification. Although neuroblastoma therapy has evolved, identification of early stage patients who need chemotherapy continues to pose a therapeutic challenge. The emerging prognostic role of MYCN phenotype of this disease is currently under investigation as it may redefine MYCN amplified subgroups. We describe an unusual case of adult neuroblastoma with MYCN amplification diagnosed incidentally and discuss possible therapeutic dilemmas.
authors.affiliation: Fourth Department of Internal Medicine, Attikon University Hospital, Rimini 1, 12462 Haidari, Athens, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Koumarianou
authors.affiliation: Department of Medical Oncology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
authors.forename: Panagiota
authors.initials: P
authors.lastname: Oikonomopoulou
authors.affiliation: Department of Pediatric Hematology-Oncology, "Pan. & Aglaia Kyriakou" Children's Hospital, Thivon & Livadias Street, 11527 Athens, Greece.
authors.forename: Margarita
authors.initials: M
authors.lastname: Baka
authors.affiliation: Laboratory Forensic Medicine and Toxicology, Evgenidion Hospital University of Athens, 76th V. Sofias, 11528 Athens, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Vlachodimitropoulos
authors.affiliation: Radiology Department, Attikon University Hospital, 1st Rimini Street, 12462 Athens, Greece.
authors.forename: Stylianos
authors.initials: S
authors.lastname: Argentos
authors.affiliation: Department of Surgery, Evgenidion Hospital, 20th Papadiamantopoulou Street, 11528 Athens, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Piperos
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, 15701 Athens, Greece.
authors.forename: Maria-Ioanna
authors.initials: MI
authors.lastname: Christodoulou
authors.affiliation: Department of Surgery, Evgenidion Hospital, 20th Papadiamantopoulou Street, 11528 Athens, Greece.
authors.forename: Kakoulis
authors.initials: K
authors.lastname: Theodoulou
authors.affiliation: Department of Surgery, Evgenidion Hospital, 20th Papadiamantopoulou Street, 11528 Athens, Greece.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Mariolis-Sapsakos