title: Novel effects of Rosa damascena extract on memory and neurogenesis in a rat model of Alzheimer's disease.
abstract: The number of older people who are suffering from memory impairment is increasing among populations throughout the world. Alzheimer's disease (AD) affects about 5% of people over 65 years old. The hippocampus, a brain area critical for learning and memory, is especially vulnerable to damage in the early stages of AD. Emerging evidence suggests that loss of neurons and synapses are correlated with dementia in this devastating disease. Therefore, neurogenesis and synaptogenesis in adulthood could serve as a preventive as well as a therapeutic target for AD. This study investigated the effect of Rosa damascena extract on neurogenesis and synaptogenesis in an animal model of AD. Molecular, cellular, and behavioral experiments revealed that this treatment could induce neurogenesis and synaptic plasticity and improve memory in AD. Our study suggests that R. damascena is a promising treatment for mild memory impairments and AD.
authors.affiliation: Department of Anatomical Sciences and Molecular Biology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Esfandiary
authors.forename: Mohammad
authors.initials: M
authors.lastname: Karimipour
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mardani
authors.forename: Hojjatallah
authors.initials: H
authors.lastname: Alaei
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ghannadian
authors.forename: Mohammad
authors.initials: M
authors.lastname: Kazemi
authors.forename: Daryoush
authors.initials: D
authors.lastname: Mohammadnejad
authors.forename: Nasrin
authors.initials: N
authors.lastname: Hosseini
authors.forename: Abolghasem
authors.initials: A
authors.lastname: Esmaeili
mesh_terms: D000544:Alzheimer Disease / Q000139:chemically induced / Q000150:complications*; D016229:Amyloid beta-Peptides / Q000633:toxicity; D058227:Amyloidogenic Proteins / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy* / Q000209:etiology*; D046529:Microscopy, Electron, Transmission; D055495:Neurogenesis / Q000187:drug effects*; D010446:Peptide Fragments / Q000633:toxicity; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D027826:Rosa / Q000737:chemistry*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure
chemical_list: D016229:Amyloid beta-Peptides; D058227:Amyloidogenic Proteins; D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels; D010446:Peptide Fragments; D010936:Plant Extracts; C075222:amyloid beta-protein (1-42)
keywords: Alzheimer's disease; Rosa damascena; neurogenesis; synaptogenesis