title: Altered tibial nerve biomechanics in patients with diabetes mellitus.
abstract: BACKGROUND
  Hyperglycemia associated with diabetes mellitus (DM) has adverse impacts on peripheral nerve connective tissue structure, and there is preliminary evidence that nerve biomechanics may be altered.
  
  
  METHODS
  Ultrasound imaging was utilized to quantify the magnitude and timing of tibial nerve excursion during ankle dorsiflexion in patients with DM and matched healthy controls.
  
  
  RESULTS
  Tibial nerve longitudinal excursion at the ankle and knee was reduced, and timing was delayed at the ankle in the DM group. Severity of neuropathy was correlated with larger reductions in longitudinal excursion. Nerve cross-sectional area was increased at the ankle in the DM group.
  
  
  CONCLUSIONS
  Larger tibial nerve size within the tarsal tunnel in patients with DM may restrict longitudinal excursion, which was most evident with more severe neuropathy. It is hypothesized that these alterations may be related to painful symptoms during functional activities that utilize similar physiological motions through various biomechanical and physiological mechanisms.
authors.affiliation: Department of Physical Therapy, Samuel Merritt University, 450 30th Street, Oakland, California, 94609, USA.
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Boyd
authors.forename: Andrew
authors.initials: A
authors.lastname: Dilley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001696:Biomechanical Phenomena / Q000502:physiology; D001786:Blood Glucose; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000294:innervation; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D016059:Range of Motion, Articular / Q000502:physiology*; D012044:Regression Analysis; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013979:Tibial Nerve / Q000000981:diagnostic imaging / Q000503:physiopathology*; D055698:Touch Perception; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: diabetes mellitus; excursion; nerve biomechanics; tibial nerve; ultrasound imaging