title: Spatio-temporal evolution on geographic boundaries of HFRS endemic areas in Shandong Province, China.
abstract: OBJECTIVE
  To take effective strategies and measures for the prevention and control of hemorrhagic fever with renal syndrome (HFRS) endemic areas by investigating its dynamic geographical boundaries in Shandong Province, China.
  
  
  METHODS
  The incidence of HFRS from 1982 to 2008 in Shandong Prvince, China, was detected with inverse distance weighting (IDW) interpolation based on geographical information system (GIS). Dynamic geographical boundaries of HFRS endemic areas in Shandong Province, China, were analyzed by geographical boundary analysis.
  
  
  RESULTS
  The HTN-type endemic areas of HFRS were located in Linyi City in phase 1 (1982-1986), the SEO-type endemic areas of HFRS were located in Jining City in phase 2 (1987-2003), and the endemic areas of HFRS in Jining City gradually disappeared and the endemic areas of HFRS with mixed-types of reservoir rodents were located in Linyi City in phase 3 (2004-2008). Meanwhile, new endemic areas emerged in the northwestern Shandong province, China.
  
  
  CONCLUSIONS
  The SEO-type endemic areas of HFRS are located in western Shandong Province, China, and the HTN-type endemic areas of HFRS are located eastern Shandong Province, Chin, indicating that the endemic areas of HFRS should be vaccinated and rodents should be controlled.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Shandong University, Jinan 250012, Shandong, China.
authors.forename: Yan Xun
authors.initials: YX
authors.lastname: Liu
authors.forename: Zhi Qiang
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.forename: Fang
authors.initials: F
authors.lastname: Tang
authors.forename: Xiu Bin
authors.initials: XB
authors.lastname: Sun
authors.forename: Fu Zhong
authors.initials: FZ
authors.lastname: Xue
authors.forename: Dian Min
authors.initials: DM
authors.lastname: Kang
mesh_terms: D002681:China / Q000453:epidemiology; D019353:Endemic Diseases; D005843:Geography; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology; D006801:Humans; D011159:Population Surveillance
keywords: Border analysis; Geographical information system (GIS); Hemorrhagic fever with renal syndrome