title: Cutaneous activation of rage in nonsystemic vasculitic and diabetic neuropathy.
abstract: BACKGROUND
  We asked whether the receptor of advanced glycation end products (RAGE) is related to dermal inflammation in nonsystemic vasculitic neuropathy (NSVN) and diabetic neuropathy (DN) and whether its presence in skin is comparable to that in sural nerve biopsies.
  
  
  METHODS
  We immunoreacted skin biopsy samples from 17 NSVN and 7 DN patients who had also undergone sural nerve biopsy, and 14 healthy controls with antibodies to advanced glycation end products (AGE), RAGE, T-cells, and macrophages.
  
  
  RESULTS
  AGE and RAGE immunoreactivity were present in vessels of nerve biopsies from NSVN and DN. AGE and RAGE were increased in dermal endothelial cells and T-cells of NSVN and DN patients compared with controls.
  
  
  CONCLUSIONS
  Dermal RAGE is increased in NSVN and DN, supporting the concept of a role of the RAGE pathway in the pathophysiology of dermal inflammation and skin denervation in NSVN and DN.
authors.affiliation: Department of Neurology, University of Würzburg, Josef-Schneider-Str. 11, 97080, Würzburg, Germany.
authors.forename: Can Ebru
authors.initials: CE
authors.lastname: Bekircan-Kurt
authors.forename: Nurcan
authors.initials: N
authors.lastname: Uçeyler
authors.forename: Claudia
authors.initials: C
authors.lastname: Sommer
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001706:Biopsy; D017252:CD3 Complex / Q000378:metabolism; D003627:Data Interpretation, Statistical; D003714:Denervation; D003872:Dermatitis / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000378:metabolism*; D005260:Female; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D000067759:Receptor for Advanced Glycation End Products / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013497:Sural Nerve / Q000378:metabolism / Q000473:pathology; D014657:Vasculitis / Q000378:metabolism*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D017252:CD3 Complex; D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; C067980:CD68 antigen, human; D000097382:CD68 Molecule
keywords: RAGE; diabetic neuropathy; inflammation; nonsystemic vasculitic neuropathy; receptor of advanced glycation end products; skin biopsy