title: Stereotactic body radiotherapy: a critical review for nonradiation oncologists.
abstract: Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate delivery of multiple radiation beams to the target. This is particularly challenging, because extracranial lesions often move with respiration and are irregular in shape, requiring careful treatment planning and continual management of this motion and patient position during irradiation. This review presents the rationale, process workflow, and technology for the safe and effective administration of SBRT, as well as the indications, outcome, and limitations for this technique in the treatment of lung cancer, liver cancer, and metastatic disease.
authors.affiliation: Department of Radiation Oncology, Duke Cancer Institute, and the Durham VA Medical Center, Durham, North Carolina.
authors.forename: John P
authors.initials: JP
authors.lastname: Kirkpatrick
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Kelsey
authors.forename: Manisha
authors.initials: M
authors.lastname: Palta
authors.forename: Alvin R
authors.initials: AR
authors.lastname: Cabrera
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Salama
authors.forename: Pretesh
authors.initials: P
authors.lastname: Patel
authors.forename: Bradford A
authors.initials: BA
authors.lastname: Perez
authors.forename: Jason
authors.initials: J
authors.lastname: Lee
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Yin
mesh_terms: D006801:Humans; D009369:Neoplasms / Q000601:surgery*; D016634:Radiosurgery / Q000379:methods*
keywords: intensity-modulated radiotherapy; liver cancer; lung cancer; normal tissue complications; oligometastases; radiosurgery; spine metastases; stereotactic body radiotherapy