title: Neutralizing antibody response in dogs and cats inoculated with commercial inactivated rabies vaccines.
abstract: In Japan, the import quarantine regulation against rabies has required from 2005 that dogs and cats should be inoculated with the rabies vaccine and that the neutralizing antibody titer should be confirmed to be at least 0.5 international units (IU)/ml. The fluorescent antibody virus neutralization (FAVN) test is used as an international standard method for serological testing for rabies. To achieve proper immunization of dogs and cats at the time of import and export, changes in the neutralizing antibody titer after inoculation of the rabies vaccine should be understood in detail. However, few reports have provided this information. In this study, we aimed to determine evaluated, such changes by using sera from experimental dogs and cats inoculated with the rabies vaccine, and we tested samples using the routine FAVN test. In both dogs and cats, proper, regular vaccination enabled the necessary titer of neutralizing antibodies to be maintained in the long term. However, inappropriate timing of blood sampling after vaccination could result in insufficient detected levels of neutralizing antibodies.
authors.affiliation: Research Institute for Animal Science in Biochemistry & Toxicology, 3-7-11 Hashimotodai, Midori-ku, Sagamihara, Kanagawa 252-0132, Japan.
authors.forename: Rikiya
authors.initials: R
authors.lastname: Shiraishi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Nishimura
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakashima
authors.forename: Chiho
authors.initials: C
authors.lastname: Enta
authors.forename: Norio
authors.initials: N
authors.lastname: Hirayama
mesh_terms: D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology*; D002371:Cat Diseases / Q000276:immunology* / Q000517:prevention & control*; D002415:Cats; D004283:Dog Diseases / Q000276:immunology* / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D007564:Japan; D008297:Male; D009500:Neutralization Tests / Q000662:veterinary; D011818:Rabies / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D057134:Antibodies, Neutralizing; D011819:Rabies Vaccines; D015164:Vaccines, Inactivated