title: Multicenter case series of indolent small/medium-sized CD8+ lymphoid proliferations with predilection for the ear and face.
abstract: We report 7 cases of a CD8 lymphoid proliferation of the ear and face with a cytotoxic T-cell phenotype, but an indolent clinical course. All patients presented with stable or slowly growing asymptomatic lesions on the ear, nose, or lower eyelid. Histopathology showed a dense diffuse dermal infiltrate of small- to medium-sized atypical lymphocytes without destructive features. The lymphocytes were positive for CD3, CD8, β-F1, and TIA-1 and negative for CD4, CD30, CD56, granzyme B, and PD-1. Of note, the proliferation index was low in available cases. All patients remained in complete remission at median follow-up of 14 months regardless of treatment modality. Staging was negative for extracutaneous disease in all patients. The clinically indolent behavior and histopathologic phenotype together with a low proliferation index (10%-15%) emphasize the importance of accurate diagnosis and appropriate clinical management to avoid overtreatment and complications of therapy.
authors.affiliation: *Department of Medicine, Dermatology Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY; †Department of Dermatology, Northwestern University, Chicago, IL; ‡Department of Pathology, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY; §Department of Dermatology and Pathology, Yale University, New Haven, CT; Departments of ¶Pathology, and ‖Dermatology, Stanford University, Stanford, CA; and **Department of Medicine, Lymphoma Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY.
authors.forename: Janet Y
authors.initials: JY
authors.lastname: Li
authors.forename: Joan
authors.initials: J
authors.lastname: Guitart
authors.forename: Melissa P
authors.initials: MP
authors.lastname: Pulitzer
authors.forename: Antonio
authors.initials: A
authors.lastname: Subtil
authors.forename: Uma
authors.initials: U
authors.lastname: Sundram
authors.forename: Youn
authors.initials: Y
authors.lastname: Kim
authors.forename: Janyana
authors.initials: J
authors.lastname: Deonizio
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Myskowski
authors.forename: Alison
authors.initials: A
authors.lastname: Moskowitz
authors.forename: Steven
authors.initials: S
authors.lastname: Horwitz
authors.forename: Christiane
authors.initials: C
authors.lastname: Querfeld
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology*; D004423:Ear / Q000473:pathology; D005145:Face / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012871:Skin Diseases / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor