title: Mitigating GI risks associated with the use of NSAIDs.
abstract: OBJECTIVE
  Nonsteroidal anti-inflammatory drugs (NSAIDs) have multiple established adverse effects on various organ systems. Among those associated with high mortality are gastrointestinal complications. We address the scope of the problem and the scientific basis for risk mitigation.
  
  
  METHODS
  This review covers the most successful of such strategies published to date.
  
  
  RESULTS
  Mitigation strategies to enable ongoing anti-inflammatory benefit are well studied, albeit imperfect.
  
  
  CONCLUSIONS
  Such strategies may involve the choice of NSAID or the combined use of gastroprotective measures in association with NSAIDs.
authors.affiliation: Department of Rheumatology, The George Washington University, Washington, District of Columbia, USA.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Momeni
authors.forename: James D
authors.initials: JD
authors.lastname: Katz
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000517:prevention & control*; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D052246:Cyclooxygenase 2 Inhibitors; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors; D016595:Misoprostol
keywords: Anti-Inflammatory; Gastrointestinal; NSAIDs