title: In vivo antibacterial activity of MRX-I, a new oxazolidinone.
abstract: MRX-I is a potent oxazolidinone antibiotic against Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), penicillin-intermediate S. pneumoniae (PISP), and vancomycin-resistant enterococci (VRE). In this study, the in vivo efficacy of orally administered MRX-I was evaluated using linezolid as a comparator. MRX-I showed the same or better efficacy than linezolid in both systemic and local infection models against the tested strains.
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Cong-Ran
authors.initials: CR
authors.lastname: Li
authors.forename: Qian-Qian
authors.initials: QQ
authors.lastname: Zhai
authors.forename: Xiu-Kun
authors.initials: XK
authors.lastname: Wang
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Hu
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Li
authors.forename: Wei-Xin
authors.initials: WX
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Pang
authors.forename: Xi
authors.initials: X
authors.lastname: Lu
authors.forename: Hong
authors.initials: H
authors.lastname: Yuan
authors.forename: Mikhail Fedorovich
authors.initials: MF
authors.lastname: Gordeev
authors.forename: Le-Tian
authors.initials: LT
authors.lastname: Chen
authors.forename: Xin-Yi
authors.initials: XY
authors.lastname: Yang
authors.forename: Xue-Fu
authors.initials: XF
authors.lastname: You
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D051379:Mice; D023303:Oxazolidinones / Q000494:pharmacology / Q000627:therapeutic use*; D010406:Penicillins / Q000494:pharmacology / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D010406:Penicillins