title: Paper-based microfluidics with high resolution, cut on a glass fiber membrane for bioassays.
abstract: In this report, we describe a simple, low-cost, straight forward and highly reproducible fabrication method of microfluidic systems. This system was cut on a glass fiber membrane by a common cutter without using any other sophisticated equipment or organic solvents. This format represents a novel type of paper-based microfluidics with high resolution of the microchannel down to ~137 μm, comparable to those made by conventional photolithography. We successfully applied this method to microfluidics to create a star micro-array format of multiplexed urine tests in this study.
authors.affiliation: Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, PR China. jlkong@fudan.edu.cn.
authors.forename: Xueen
authors.initials: X
authors.lastname: Fang
authors.forename: Shasha
authors.initials: S
authors.lastname: Wei
authors.forename: Jilie
authors.initials: J
authors.lastname: Kong
mesh_terms: D001681:Biological Assay / Q000295:instrumentation; D005898:Glass / Q000737:chemistry; D005947:Glucose / Q000032:analysis; D007657:Ketone Bodies / Q000652:urine; D008567:Membranes, Artificial; D046228:Microarray Analysis; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods*; D009573:Nitrites / Q000652:urine; D010209:Paper; D011506:Proteins / Q000032:analysis
chemical_list: D007657:Ketone Bodies; D008567:Membranes, Artificial; D009573:Nitrites; D011506:Proteins; C009753:fiberglass; D005947:Glucose