title: Preparation and pH controlled release of polyelectrolyte complex of poly(L-malic acid-co-D,L-lactic acid) and chitosan.
abstract: The copolymer of poly(L-malic acid-co-D,L-lactic acid) (PML) was synthesized through a direct polycondensation of L-malic acid (MA) and D,L-lactic acid (LA). Then, a new polyelectrolyte complex (PEC) based on the complexation between the copolymer (PML) and chitosan (CS) was prepared. The PEC formed stable nano particles in aqueous solutions with pH 3-5, and the nano particles had the diameters in a range of 316-590 nm (varied with the components of PML and CS). Doxorubicin (DOX) as a model drug was loaded on the nano particles through the physical adsorption and complexation, and part of DOX formed the secondary particles by self-aggregation. The high drug loading efficiency (16.5%) and the sustained release patterns in acidic media were observed, and the release accelerated in alkaline solutions. The nano particles could be potentially applied as pH sensitive drug vehicles for controlled release.
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR China. Electronic address: nicaihua2000@163.com.
authors.forename: Caihua
authors.initials: C
authors.lastname: Ni
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR China.
authors.forename: Yanan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR China.
authors.forename: Wang
authors.initials: W
authors.lastname: Li
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR China.
authors.forename: Bolong
authors.initials: B
authors.lastname: Yao
authors.affiliation: The Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, PR China.
authors.forename: Liping
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000494:pharmacology; D004573:Electrolytes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008970:Molecular Weight; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry* / Q000633:toxicity; D012996:Solutions; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry
chemical_list: D003692:Delayed-Action Preparations; D004573:Electrolytes; D011091:Polyesters; D012996:Solutions; C551150:poly(lactic acid-co-malic acid); D004317:Doxorubicin; D048271:Chitosan
keywords: Biodegradable materials; Drug delivery; Nano particle; Poly(malic acid-co-lactic acid); Polyelectrolyte complex