title: Clinical healing rates of meniscus repairs of tears in the central-third (red-white) zone.
abstract: OBJECTIVE
  To determine the clinical healing rate of repairs of meniscus tears that extend into the central one-third region and the factors that affect the outcome.
  
  
  METHODS
  A systematic search of PubMed was conducted to determine the outcome of meniscus repairs in the red-white (R/W) zone. Inclusion criteria were as follows: English language, clinical trials published from 1996 to 2013, R/W tears analyzed separately from tears in other zones, arthroscopic suture-based repairs, and all evidence levels.
  
  
  RESULTS
  Of 344 articles identified, 23 met the inclusion criteria. There were 1,232 patients who had 1,326 meniscus repairs, of which 767 were in the R/W zone. Concurrent anterior cruciate ligament reconstruction was performed in 955 patients (78%). The mean age was 25 years, and the mean follow-up was 4 years. Evaluation criteria included clinical examination in 22 studies, follow-up arthroscopy in 15, magnetic resonance imaging in 6, weight-bearing radiographs in 3, and the International Knee Documentation Committee subjective score in 1. Overall, 637 (83%) of the repairs were considered clinically healed because no additional surgery was required and no obvious clinical meniscus symptoms were detected. This included 382 of 470 inside-out suture repairs (81%) and 255 of 297 all-inside suture repairs (86%). Twenty-two factors were assessed in 13 studies to determine their influence on the outcome, with varying results. Authors generally found that patient age, chronicity of injury, involved tibiofemoral compartment, gender, and concurrent anterior cruciate ligament reconstruction did not adversely affect the results. Insufficient data existed to assess the healing rates according to the type of meniscus tear except for single longitudinal tears. Complications were reported in 3% of the patients in this review. Long-term assessment of a chondroprotective effect of the repairs was conducted in only 2 studies.
  
  
  CONCLUSIONS
  An acceptable midterm clinical healing rate was found for R/W meniscus repairs, supporting this procedure when appropriately indicated. Long-term studies assessing the chondroprotective effect in the involved tibiofemoral compartment using magnetic resonance imaging and radiographs are needed.
  
  
  METHODS
  Level IV, systematic review of Level I-IV studies.
authors.affiliation: Cincinnati SportsMedicine and Orthopaedic Center, Noyes Knee Institute, and Jewish Hospital-Mercy Health, Cincinnati, Ohio, U.S.A.. Electronic address: sbwestin@csmref.org.
authors.forename: Sue D
authors.initials: SD
authors.lastname: Barber-Westin
authors.affiliation: Cincinnati SportsMedicine and Orthopaedic Center, Noyes Knee Institute, and Jewish Hospital-Mercy Health, Cincinnati, Ohio, U.S.A.
authors.forename: Frank R
authors.initials: FR
authors.lastname: Noyes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001182:Arthroscopy / Q000009:adverse effects / Q000379:methods; D002648:Child; D019317:Evidence-Based Medicine; D005500:Follow-Up Studies; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology; D022125:Lacerations / Q000145:classification / Q000503:physiopathology* / Q000601:surgery*; D008592:Menisci, Tibial / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D011859:Radiography; D016059:Range of Motion, Articular; D020127:Recovery of Function; D012421:Rupture / Q000601:surgery; D000070600:Tibial Meniscus Injuries; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult