title: Bifunctional thiosialosides inhibit influenza virus.
abstract: We have synthesized a panel of bivalent S-sialoside analogues, with modifications at the 4 position, as inhibitors of influenza virus. These first generation compounds show IC50 values ranging from low micromolar to high nanomolar in enzyme inhibition and plaque reduction assays with two intact viruses, Influenza H1N1 (A/California/07/2009) and H3N2 (A/Hongkong/8/68).
authors.affiliation: 788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: 788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
authors.forename: Yun
authors.initials: Y
authors.lastname: He
authors.affiliation: 788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
authors.forename: Xingzhe
authors.initials: X
authors.lastname: Li
authors.affiliation: 788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States.
authors.forename: Hieu
authors.initials: H
authors.lastname: Dinh
authors.affiliation: 788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30302, United States. Electronic address: siyer@gsu.edu.
authors.forename: Suri S
authors.initials: SS
authors.lastname: Iyer
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000502:physiology; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000502:physiology; D019158:N-Acetylneuraminic Acid / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D019158:N-Acetylneuraminic Acid
keywords: Bifunctional; Glycoconjugates; Influenza virus; Inhibitors; Sialic acid