title: Effect of holmium laser enucleation of prostate on overactive bladder symptoms and urodynamic parameters: a prospective study.
abstract: OBJECTIVE
  To analyze the effect of Holmium laser enucleation of prostate (HoLEP) on overactive bladder (OAB) symptoms and urodynamic parameters in patients with benign prostatic hyperplasia.
  
  
  METHODS
  One hundred sixty-five patients were included in this prospective study. They complained of lower urinary tract symptoms suggestive of benign prostatic hyperplasia and underwent HoLEP by a surgeon from January 2010 to March 2012. We analyzed the results of International Prostate Symptom Score, overactive bladder questionnaire, frequency-volume chart, and urodynamic studies (UDS) before and after the surgery. Follow-up examinations were repeated 3 and 6 months postoperatively, and a UDS was performed at 6 months after the surgery.
  
  
  RESULTS
  The mean age was 68.4 (range, 52-91) years, the preoperative prostate volume measured by transrectal ultrasound was 71.1 (range, 22-202) mL, and the serum PSA level was 4.4 (range, 0.5-21.7) ng/mL. Postoperatively, patients showed significant improvement in the International Prostate Symptom Score (total score from 20.7 to 5.5, P <.001), overactive bladder questionnaire score (severity score from 24.8 to 12.5, P <.001), and frequency-volume chart parameters (daytime frequency, nocturia, and maximal capacity, respectively) (P <.001). The peak flow rate (P <.001), postvoid residual urine volume (P <.001), maximal cystometric capacity (P <.002), and bladder outlet obstruction index (P <.001) have improved significantly. The number of patients who showed involuntary detrusor contraction in UDS decreased significantly from 45.5% to 36.4% (P <.001). However, bladder compliance did not improve.
  
  
  CONCLUSIONS
  OAB symptoms and urodynamic parameters were improved significantly after HoLEP surgery in short-term follow-up.
authors.affiliation: Department of Urology, Seoul National University Hospital, Seoul, South Korea.
authors.forename: Ohseong
authors.initials: O
authors.lastname: Kwon
authors.affiliation: Department of Urology, Seoul National University Hospital, Seoul, South Korea.
authors.forename: Hahn-Ey
authors.initials: HE
authors.lastname: Lee
authors.affiliation: Department of Urology, Dongguk University Ilsan Hospital, Goyang-si, Gyeonggi-do, South Korea.
authors.forename: Jungbum
authors.initials: J
authors.lastname: Bae
authors.affiliation: Department of Urology, Gachon University Gil Hospital, Incheon, South Korea.
authors.forename: Jin Kyu
authors.initials: JK
authors.lastname: Oh
authors.affiliation: Department of Urology, Seoul National University Hospital, Seoul, South Korea. Electronic address: sjo@snu.ac.kr.
authors.forename: Seung-June
authors.initials: SJ
authors.lastname: Oh
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D053448:Prostatism / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D012720:Severity of Illness Index; D014463:Ultrasonography; D053201:Urinary Bladder, Overactive / Q000150:complications / Q000503:physiopathology* / Q000601:surgery*; D014563:Urodynamics