title: Roles of cellular polyamines in mucosal healing in the gastrointestinal tract.
abstract: The mammalian gastrointestinal (GI) mucosa is a rapidly self-renewing tissue in the body, and its integrity is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. Polyamines are shown to play an important role in the regulation of gastrointestinal mucosal growth and healing after injury under physiological and various pathological conditions. In this review, we highlight the importance of cellular polyamines in the control GI mucosal proliferation, migration, apoptosis, angiogenesis and GI barrier function during mucosal repair after injury.
authors.affiliation: Division of Peptides Related with Human Diseases, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China. shcqcdmed@163.com; jrao@umaryland.edu.
authors.forename: J-H
authors.initials: JH
authors.lastname: Gao
authors.forename: L-J
authors.initials: LJ
authors.lastname: Guo
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Huang
authors.forename: J N
authors.initials: JN
authors.lastname: Rao
authors.forename: C-W
authors.initials: CW
authors.lastname: Tang
mesh_terms: D000818:Animals; D017209:Apoptosis; D005767:Gastrointestinal Diseases / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000293:injuries / Q000378:metabolism*; D044342:Malnutrition / Q000378:metabolism; D018919:Neovascularization, Physiologic; D011073:Polyamines / Q000378:metabolism*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D011073:Polyamines