title: Successful Management of Hydroxyurea-induced Leg Ulcers in Essential Thrombocythemia: Report of 3 Cases.
abstract: Essential thrombocythemia is one of the myeloproliferative neoplasms with a plethora of thrombohemorrhagic complications.Hydroxyurea has been proven to be an effective treatment for this condition. However, it is not without side effects. We herein report 3 patients with essential thrombocythemia treated with hydroxyurea who developed refractory leg ulcers, and we outline their successful management. We also review the literature to shed light on the mechanism of this toxicity. Awareness of this important treatment complication is important to avoid the pitfall of futile invasive interventions.
authors.affiliation: American University of Beirut Medical Center, Department of Internal Medicine, Beirut, Lebanon ; American University of Beirut Medical Center, Department of Internal Medicine, Beirut, Lebanon.
authors.forename: Jihane Abou
authors.initials: JA
authors.lastname: Rahal
authors.affiliation: American University of Beirut Medical Center, Department of Internal Medicine, Beirut, Lebanon.
authors.forename: Rim S
authors.initials: RS
authors.lastname: Ishak
authors.affiliation: American University of Beirut Medical Center, Department of Internal Medicine, Beirut, Lebanon.
authors.forename: Zaher K
authors.initials: ZK
authors.lastname: Otrock
authors.affiliation: American University of Beirut Medical Center, Department of Internal Medicine, Beirut, Lebanon.
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Maakaron
authors.affiliation: American University of Beirut Medical Center, Department of Internal Medicine, Beirut, Lebanon.
authors.forename: Samer
authors.initials: S
authors.lastname: Ghosn
authors.affiliation: American University of Beirut Medical Center, Department of Internal Medicine, Beirut, Lebanon.
authors.forename: Ali T
authors.initials: AT
authors.lastname: Taher
keywords: Essential thrombocythemia; Hydroxyurea; Interferon; Leg ulcers