title: Use of small RNA as antiaging cosmeceuticals.
abstract: Over the past two decades, RNA interference (RNAi) has achieved great improvements in medicine, which has benefited the development of innovative cosmeceutical products, particular, to antiaging cosmeceuticals. A variety of ongoing research has tried to employ small RNAs-small interference RNA and microRNA as new cosmeceutical ingredients. Furthermore, several skin care companies have released new small RNA products in cosmetic market. In this review, we will describe the latest and most advanced approaches and strategies of using small RNA as antiaging cosmetics, including investigations on aging-related genes that small RNA target, method of delivering them, and challenges in the development of RNAi-based therapeutics for skin care cosmeceuticals. It is certain that advancement in this direction will evolve a new landscape for innovative antiaging cosmeceuticals.
authors.affiliation: Biomics Biotechnologies Co. Ltd, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016, and Small RNA Technology and Application Institute, Nantong University, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016.
authors.forename: Pingjing
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Biomics Biotechnologies Co. Ltd, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016, and Small RNA Technology and Application Institute, Nantong University, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Chen
authors.affiliation: Biomics Biotechnologies Co. Ltd, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016, and Small RNA Technology and Application Institute, Nantong University, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016.
authors.forename: Tiejun
authors.initials: T
authors.lastname: Li
authors.affiliation: Biomics Biotechnologies Co. Ltd, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016, and Small RNA Technology and Application Institute, Nantong University, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016.
authors.forename: York Yuanyuan
authors.initials: YY
authors.lastname: Zhu
mesh_terms: D002463:Cell Membrane Permeability; D057846:Cell-Penetrating Peptides / Q000378:metabolism; D003358:Cosmetics / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods; D018390:Gene Targeting / Q000379:methods; D006801:Humans; D035683:MicroRNAs / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D036103:Nanotechnology / Q000379:methods; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects* / Q000502:physiology
chemical_list: D057846:Cell-Penetrating Peptides; D003358:Cosmetics; D035683:MicroRNAs; D034741:RNA, Small Interfering