title: Aneuploidy: implications for protein homeostasis and disease.
abstract: It has long been appreciated that aneuploidy - in which cells possess a karyotype that is not a multiple of the haploid complement - has a substantial impact on human health, but its effects at the subcellular level have only recently become a focus of investigation. Here, we summarize new findings characterizing the impact of aneuploidy on protein quality control. Because aneuploidy has been associated with many diseases, foremost among them being cancer, and has also been linked to aging, we also offer our perspective on whether and how the effects of aneuploidy on protein quality control could contribute to these conditions. We argue that acquiring a deeper understanding of the relationship between aneuploidy, disease and aging could lead to the development of new anti-cancer and anti-aging treatments.
authors.affiliation: David H. Koch Institute for Integrative Cancer Research, Department of Biology and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Ana B
authors.initials: AB
authors.lastname: Oromendia
authors.forename: Angelika
authors.initials: A
authors.lastname: Amon
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism; D000782:Aneuploidy; D000818:Animals; D004314:Down Syndrome / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007621:Karyotyping; D051379:Mice; D008822:Mice, Transgenic; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D010641:Phenotype; D017510:Protein Folding; D040901:Proteomics; D057165:Proteostasis Deficiencies / Q000235:genetics* / Q000378:metabolism; D011786:Quality Control
chemical_list: D018832:Molecular Chaperones
keywords: Aneuploidy; Disease; Protein folding