title: [Roles of peroxisome proliferator-activated receptors polymorphisms, haplotypes, levels on C-reactive protein and their interactions with abnormal body weight].
abstract: OBJECTIVE
  To explore the roles of peroxisome proliferator-activated receptors (PPARs) on the levels of serum C-reactive protein(CRP)and the interactions of PPARs haplotypes with abnormal body weight.
  
  
  METHODS
  Subjects(n = 644)were randomly selected from the cohort 'Prevention of Multiple metabolic disorders and Metabolic syndrome in Jiangsu province(PMMJS)' Variance test, t test and lineal regression were used to analyze the associations between PPARs polymorphisms and the levels of CRP. The association between PPARs haplotypes and serum CRP levels as well as the interaction of PPARs haplotypes with abnormal body weight were analyzed, under the SNPStats software.
  
  
  RESULTS
  After adjusting for sex, age, blood pressure, cigarette smoking, alcohol drinking and so on, data showed that both rs1800206 and rs9794 were associated with the changes along with the levels of CRP (P < 0.05). After adjusting for the same factors, haplotypes of AVG and CVG in PPARα, CG in PPARd appeared to be associated with the increase (P < 0.05)while haplotypes of CC in PPARδ, CPCAC in PPARγ were associated with the decrease of CRP levels (P < 0.05). Results from the Interaction analysis also noted that the interactions did exist between abnormal body weight and both AVG, CVG in PPARα, and CG in PPARδ.
  
  
  CONCLUSIONS
  PPARs polymorphisms and haplotypes were associated with CRP. Interaction between PPAR a/d and abnormal body weight might contribute to the levels of CRP.
authors.affiliation: Suzhou Industrial Park Center for Disease Control and Prevention, Suzhou 215021, China.
authors.forename: Lu-gang
authors.initials: LG
authors.lastname: Yu
authors.affiliation: Changshu Center for Disease Control and Prevention.
authors.forename: Zheng-yuan
authors.initials: ZY
authors.lastname: Zhou
authors.affiliation: Department of Epidemiology, School of Public Health, Soochow University. Email: guozhirong28@163.com.
authors.forename: Zhi-rong
authors.initials: ZR
authors.lastname: Guo
authors.affiliation: Jiangsu Provincial Center for Disease Control and Prevention.
authors.forename: Ming
authors.initials: M
authors.lastname: Wu
authors.affiliation: Department of Epidemiology, School of Public Health, Soochow University.
authors.forename: Shu-jun
authors.initials: SJ
authors.lastname: Gu
mesh_terms: D000328:Adult; D001835:Body Weight; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D050177:Overweight / Q000235:genetics* / Q000378:metabolism*; D047492:Peroxisome Proliferator-Activated Receptors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D047492:Peroxisome Proliferator-Activated Receptors; D002097:C-Reactive Protein