title: [Prospective study of gluco-lipidic hormone and peptide levels in morbidly obese patients after sleeve gastrectomy].
abstract: BACKGROUND
  Different hormones and peptides involved in lipid and carbohydrate metabolism have been studied in relation to morbid obesity and its variation after bariatric surgery. The aim of this study is toevaluate variations in different molecules related to glico-lipidic metabolism during the first year after sleeve gastrectomy in morbidly obese patients.
  
  
  METHODS
  Prospective study in patients undergoing sleeve gastrectomy between November 2009 and January 2011. We analyzed changes in different clinical, anthropometric and analytic parameters related with glico-lipidic metabolism in all patients in the preoperative period, first postoperative day, fifth day, one month, 6 months and one year after surgery. Statistical analysis was performed using SPSS 20.0.
  
  
  RESULTS
  We included 20 patients, 60% were women with a median of age of 45 years. Median of body mass index (IMC) was 48,5 kg/m(2) and 70% had obstructive sleep apnea syndrome (SAOS), 65% arterial hypertension (HTA), 45% dyslipidemia and 40% diabetes mellitus. One year after surgery, the percentage of excess of BMI loss was 72% and the rate of cure or improvement of dyslipidemia was 100%, diabetes 87,5%, HTA 84,6% and SAOS 57,1%. At this time, glycemia levels decreased significantly (P<.001), and levels of IGF-1 and HDL-cholesterol increased significantly. Levels of adiponectine increased and leptine (P=.003), insulin (P=.004) and triglycerides (P=.016) decreased significantly one year after the surgery. ACTH levels (that decreased during first 6 months after surgery), glycosilated hemoglobin, total cholesterol and LDL-cholesterol had no changes one year after surgery.
  
  
  CONCLUSIONS
  Sleeve gastrectomy is a surgical technique with good results of weight loss and cure of comorbidities. This procedure induces significant modifications in blood levels of glico-lipidic metabolism related peptides and hormones, such as glucose, IGF-1, insulin, leptin, triglycerides and HDL-cholesterol.
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Consorcio Hospital General Universitario de Valencia, Valencia, España. Electronic address: drbruna@comv.es.
authors.forename: Marcos
authors.initials: M
authors.lastname: Bruna
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Verónica
authors.initials: V
authors.lastname: Gumbau
authors.affiliation: Servicio de Análisis Clínicos, Centro de Diagnóstico Biomédico, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Marcos
authors.initials: M
authors.lastname: Guaita
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Enrique
authors.initials: E
authors.lastname: Canelles
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Claudia
authors.initials: C
authors.lastname: Mulas
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Carla
authors.initials: C
authors.lastname: Basés
authors.affiliation: Servicio de Análisis Clínicos, Centro de Diagnóstico Biomédico, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Isabel
authors.initials: I
authors.lastname: Celma
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: José
authors.initials: J
authors.lastname: Puche
authors.affiliation: Servicio de Análisis Clínicos, Centro de Diagnóstico Biomédico, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Goitzane
authors.initials: G
authors.lastname: Marcaida
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Miguel
authors.initials: M
authors.lastname: Oviedo
authors.affiliation: Servicio de Cirugía General y del Aparato Digestivo, Consorcio Hospital General Universitario de Valencia, Valencia, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Vázquez
mesh_terms: D052242:Adiponectin / Q000097:blood; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D005260:Female; D005743:Gastrectomy / Q000379:methods; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery*; D011446:Prospective Studies; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D000324:Adrenocorticotropic Hormone; D001786:Blood Glucose; D002784:Cholesterol; D006442:Glycated Hemoglobin; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D020738:Leptin; D014280:Triglycerides
keywords: Gastrectomía vertical; Glycolipidic metabolism; Metabolismo glucolipídico; Obesidad; Obesity; Sleeve gastrectomy