title: Studying the activity of antitubercluosis drugs inside electrospun polyvinyl alcohol, polyethylene oxide, and polycaprolacton nanofibers.
abstract: The activity of antituberculosis drugs (streptomycin sulfate, isoniazid, pyrazinamid, and clarithromycin) embedded in biodegradable nanofibers against Mycobacterium avium has been studied by broth dilution assay and by agar plate assay. These drugs have also been embedded in electrospun polyvinyl alcohol (PVA), polyethylene oxide (PEO), and polycaprolacton (PCL) nanofibers to design a new single tablet containing first-line antituberculosis drugs. Our results show that antituberculosis drugs are active at tiny amounts (up to 300 µg mL(-1) of solvent). However, within polymer matrices, high amounts of drugs are required to avoid unwanted weak interactions within PEO and PCL matrices. The successful design of a single tablet containing required amounts of antituberculosis drugs is essential for the full treatment of tuberculosis in patients with HIV.
authors.affiliation: Institute for Critical Technology and Applied Sciences (ICTAS), Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061.
authors.forename: Ibrahim Anwar
authors.initials: IA
authors.lastname: Hassounah
authors.forename: Nader Abdelmonem
authors.initials: NA
authors.lastname: Shehata
authors.forename: Gade Carolyn
authors.initials: GC
authors.lastname: Kimsawatde
authors.forename: Amanda Gayle
authors.initials: AG
authors.lastname: Hudson
authors.forename: Nammalwar
authors.initials: N
authors.lastname: Sriranganathan
authors.forename: Eugene Gregory
authors.initials: EG
authors.lastname: Joseph
authors.forename: Roop L
authors.initials: RL
authors.lastname: Mahajan
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D009162:Mycobacterium avium / Q000254:growth & development*; D057139:Nanofibers / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D014376:Tuberculosis / Q000188:drug therapy / Q000209:etiology
chemical_list: D000995:Antitubercular Agents; D011091:Polyesters; C016240:polycaprolactone; D011092:Polyethylene Glycols; D011142:Polyvinyl Alcohol
keywords: drug delivery; electrospinning; nanofibers; tuberculosis