title: Quinoline-3-carboxamides modulate primary T cell-dependent B cell responses but do not inhibit functional immunity.
abstract: The effect of a quinoline-3-carboxamide on the T cell-dependent B cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal centre (GC) B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of GCs formed and their size were reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response, there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune diseases without being immunosuppressive.
authors.affiliation: Immunology Group, Lund University, Lund, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Källberg
authors.forename: F
authors.initials: F
authors.lastname: Ivars
authors.forename: T
authors.initials: T
authors.lastname: Leanderson
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002478:Cells, Cultured; D002645:Chickens; D018858:Germinal Center / Q000276:immunology*; D006241:Haptens / Q000008:administration & dosage* / Q000276:immunology; D056724:Immunity, Humoral / Q000187:drug effects; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood; D056747:Immunomodulation; D018655:Lymphocyte Count; D051379:Mice; D008810:Mice, Inbred C57BL; D009596:Nitrophenols / Q000737:chemistry / Q000276:immunology; D010648:Phenylacetates / Q000737:chemistry / Q000276:immunology; D011804:Quinolines / Q000008:administration & dosage* / Q000276:immunology; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D005719:gamma-Globulins / Q000737:chemistry / Q000276:immunology
chemical_list: D006241:Haptens; D007074:Immunoglobulin G; D009596:Nitrophenols; D010648:Phenylacetates; D011804:Quinolines; D005719:gamma-Globulins; C541322:quinoline-3-carboxamide; C026242:4-hydroxy-5-nitrophenyl acetic acid