title: Immune reconstitution inflammatory syndrome Kaposi sarcoma in the liver manifesting as acute obstructive hepatitis: another potential role for montelukast?
abstract: Immune reconstitution inflammatory syndrome has been described in Kaposi sarcoma, but does not usually manifest as acute hepatitis. We describe a case of rapid obstructive jaundice after initiation of antiretroviral therapy, in which the liver biopsy confirmed hepatic Kaposi sarcoma, and the clinical course was altered by the addition of montelukast.
authors.forename: P J
authors.initials: PJ
authors.lastname: Read
authors.forename: S
authors.initials: S
authors.lastname: Lucas
authors.forename: S
authors.initials: S
authors.lastname: Morris
authors.forename: R
authors.initials: R
authors.lastname: Kulasegaram
mesh_terms: D000085:Acetates / Q000627:therapeutic use*; D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D018791:CD4 Lymphocyte Count; D003521:Cyclopropanes; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications* / Q000188:drug therapy; D041781:Jaundice, Obstructive / Q000188:drug therapy / Q000209:etiology*; D020024:Leukotriene Antagonists / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011804:Quinolines / Q000627:therapeutic use*; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D012878:Skin Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology* / Q000821:virology; D013440:Sulfides; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D000085:Acetates; D044966:Anti-Retroviral Agents; D000970:Antineoplastic Agents; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast