title: [The role of fetuin-A in cardiovascular diseases].
abstract: Fetuin-A (also known as α2-Heremans-Schmid glycoprotein) is a multifunctional molecule secreted by the liver. It is a negative acute phase reactant with a debated role in subclinical inflammation. Fetuin-A is an inhibitor of the insulin receptor and its serum level correlates with insulin resistance. The protein has been implicated in adipocyte dysfunction and it is associated with obesity and non-alcoholic fatty liver disease. Although all these properties seem to promote atherosclerosis, the role of fetuin-A in cardiovascular diseases is more complex. As a natural inhibitor of tissue and vascular calcification, fetuin-A also acts as a protective factor in atherosclerosis. The potential role and prognostic value of fetuin-A in arterial calcification and cardiovascular diseases is discussed in this review, along with explanations for seemingly contradicting results in the literature and possible directions for future research.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Családorvosi Tanszék Budapest Kútvölgyi út 4. 1125.
authors.forename: Krisztián
authors.initials: K
authors.lastname: Vörös
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Népegészségtani Intézet Budapest.
authors.forename: Károly
authors.initials: K
authors.lastname: Cseh
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar Családorvosi Tanszék Budapest Kútvölgyi út 4. 1125.
authors.forename: László
authors.initials: L
authors.lastname: Kalabay
mesh_terms: D017667:Adipocytes / Q000378:metabolism; D050197:Atherosclerosis / Q000378:metabolism; D002114:Calcinosis / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism; D006801:Humans; D024821:Metabolic Syndrome / Q000378:metabolism; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D011972:Receptor, Insulin / Q000037:antagonists & inhibitors; D015430:Weight Gain; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*
chemical_list: C556354:AHSG protein, human; D005230:Fatty Acids, Nonesterified; D060749:alpha-2-HS-Glycoprotein; D011972:Receptor, Insulin
keywords: adipocytadiszfunkció; adipocyte dysfunction; arterial calcification; artériakalcifikáció; cardiovascular disease; cardiovascularis betegségek; fetuin-A; insulin resistance; inzulinrezisztencia