title: Perirenal space blocking restores gastrointestinal function in patients with severe acute pancreatitis.
abstract: OBJECTIVE
  To investigate effects of perirenal space blocking (PSB) on gastrointestinal function in patients with severe acute pancreatitis (SAP).
  
  
  METHODS
  Forty patients with SAP were randomly allocated to receive PSB or no PSB (NPSB). All the SAP patients received specialized medical therapy (SMT). Patients in the PSB group received PSB + SMT when hospitalized and after diagnosis, whereas patients in the NPSB group only received SMT. A modiﬁed gastrointestinal failure (GIF) scoring system was used to assess the gastrointestinal function in SAP patients after admission. Pain severity (visual analog scale, 0 to 100) was monitored every 24 h for 72 h.
  
  
  RESULTS
  Modified GIF score decreased in both groups during the 10-d study period. The median score decrease was initially significantly greater in the PSB group than in the NPSB group after PSB was performed. During the 72-h study period, pain intensity decreased in both groups. The median pain decrease was significantly greater in the PSB group than in the NPSB group at single time points. Patients in the PSB group had significantly lower incidences of hospital mortality, multiple organ dysfunction syndrome, systemic inflammatory response syndrome, and pancreatic infection, and stayed in the intensive care unit for a shorter duration. However, no difference in terms of operation incidence was found between the two groups.
  
  
  CONCLUSIONS
  PSB could ameliorate gastrointestinal dysfunction or failure during the early stage of SAP. Moreover, PSB administration could improve prognosis and decrease the mortality of SAP patients.
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Jun-Jun
authors.initials: JJ
authors.lastname: Sun
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Zhi-Jie
authors.initials: ZJ
authors.lastname: Chu
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Liu
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Shi-Fang
authors.initials: SF
authors.lastname: Qi
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Yang
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Peng-Lei
authors.initials: PL
authors.lastname: Ge
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Li
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.affiliation: Jun-Jun Sun, Zhi-Jie Chu, Wei-Feng Liu, Shi-Fang Qi, Yan-Hui Yang, Peng-Lei Ge, Xiao-Hui Zhang, Wen-Sheng Li, Cheng Yang, Yu-Ming Zhang, Department of General Surgery, the First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Zhang
mesh_terms: D015746:Abdominal Pain / Q000209:etiology / Q000628:therapy; D000208:Acute Disease; D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002447:Celiac Plexus / Q000503:physiopathology*; D002681:China; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D005769:Gastrointestinal Motility; D017052:Hospital Mortality; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009407:Nerve Block / Q000379:methods*; D010195:Pancreatitis / Q000150:complications / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D011446:Prospective Studies; D020127:Recovery of Function; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine
keywords: Gastrointestinal function; Perirenal space blocking; Prognosis; Severe acute pancreatitis; Therapeutics