title: Significance of CASP8AP2 and H2AFZ expression in survival and risk of relapse in children with acute lymphoblastic leukemia.
abstract: Novel biomarkers for risk refinement and stratification in childhood acute lymphoblastic leukemia (ALL) are needed to optimize treatment results. We studied the expression of CASP8AP2 and H2AFZ associated with relapse and survival in bone marrow samples from newly diagnosed children with ALL. We found: (a) an increased risk for early relapse in those patients with low expression of CASP8AP2 (odds ratio [OR] 3.93, 95% confidence interval [CI] 1.40-11.02, p < 0.05) confirming its usefulness as a predictive risk marker, although H2AFZ did not present the same effect; (b) patients with low expressions of CASP8AP2 and H2AFZ had inferior survival rates (p < 0.001); (c) the predictive values regarding low expressions of H2AFZ and CASP8AP2 and high white blood cell count suggest that these features could help to identify more accurately patients at greater risk of relapse.
authors.affiliation: Laboratorio de Cultivo de Tejidos, Instituto Nacional de Pediatría , México D.F. , México.
authors.forename: Rocío
authors.initials: R
authors.lastname: Juárez-Velázquez
authors.forename: Adriana
authors.initials: A
authors.lastname: Reyes-León
authors.forename: Consuelo
authors.initials: C
authors.lastname: Salas-Labadía
authors.forename: Roberto
authors.initials: R
authors.lastname: Rivera-Luna
authors.forename: Liliana
authors.initials: L
authors.lastname: Velasco-Hidalgo
authors.forename: Gerardo
authors.initials: G
authors.lastname: López-Hernández
authors.forename: Norma
authors.initials: N
authors.lastname: López-Santiago
authors.forename: Rogelio
authors.initials: R
authors.lastname: Paredes-Aguilera
authors.forename: Aarón
authors.initials: A
authors.lastname: Domínguez-López
authors.forename: Roberto
authors.initials: R
authors.lastname: Bernáldez
authors.forename: Patricia
authors.initials: P
authors.lastname: Pérez-Vera
mesh_terms: D000293:Adolescent; D051017:Apoptosis Regulatory Proteins / Q000235:genetics*; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015870:Gene Expression; D006657:Histones / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D011379:Prognosis; D012008:Recurrence; D012306:Risk
chemical_list: D051017:Apoptosis Regulatory Proteins; D014408:Biomarkers, Tumor; C485604:CASP8AP2 protein, human; D002135:Calcium-Binding Proteins; D006657:Histones
keywords: Acute lymphoblastic leukemia; CASP8AP2 expression; H2AFZ expression; childhood; risk of relapse