title: Postsurgical coagulopathy in a hemophilia A patient with inhibitors: efficacy of recombinant factor VIIa.
abstract: Perioperative hemostatic management in patients with hemophilia A who develop the coagulation factor VIII (FVIII) inhibitor is challenging, because exogenous FVIII is neutralized, which boosts the inhibitor to provoke postoperative coagulopathy. Recombinant activated factor VII (rFVIIa) has become available for this type of patient, although FVIII is sometimes required. We treated a 56-year-old male patient with hemophilia A with FVIII inhibitor scheduled for total hip arthroplasty (THA) and total knee arthroplasty (TKA). We used rFVIIa for THA; however, the amount of bleeding was 2,500 ml and blood transfusion was required, which boosted FVIII inhibitor after surgery. The TKA was then scheduled for 19 months later, after the level of the inhibitor had reduced to the preoperative level. Unfortunately, rFVIIa failed to improve PT/APTT, and thus we used recombinant factor VIII (rFVIII). The amount of bleeding during TKA was 1,340 ml, while the level of the inhibitor increased to a greater level than that after THA, provoking uncontrollable bleeding. For anesthetic management in hemophilia A patients with FVIII inhibitor, anesthesiologists must pay attention to postoperative coagulopathy, and every effort should be used to minimize exposure to FVIII. Furthermore, when rFVIIa is ineffective, postponement of surgery until rFVIIa regains its efficacy may be beneficial as compared to an operation with FVIII.
authors.affiliation: Department of Anesthesiology and Critical Care, Hiroshima University School of Medicine, 1-2-3, Kasumi, Minami, Hiroshima, 734-8551, Japan, nsaeki@hiroshima-u.ac.jp.
authors.forename: Noboru
authors.initials: N
authors.lastname: Saeki
authors.forename: Saya
authors.initials: S
authors.lastname: Mochizuki
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Fujii
authors.forename: Masashi
authors.initials: M
authors.lastname: Kawamoto
mesh_terms: D019643:Arthroplasty, Replacement; D001778:Blood Coagulation Disorders / Q000209:etiology*; D001803:Blood Transfusion; D015942:Factor VIIa / Q000627:therapeutic use*; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D011183:Postoperative Complications / Q000097:blood*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa