title: Prolonged remission of juvenile-onset respiratory papillomatosis: a post-expositional role of the tetravalent anti-HPV vaccine?
abstract: Juvenile-onset recurrent respiratory papillomatosis (JORRP) is an HPV-related neoplasm affecting primarily the larynx. JORRP often requires repeated surgical debridement, which yield variable but generally moderate remission periods. We report the case of a 6-year-old boy with severe course JORRP since the age of 2, requiring tracheostomy, that underwent prolonged remission and was decannulated some months after administration of the HPV vaccine. The post-exposure use for the anti-HPV vaccine in JORRP is a topic of capital interest but still poorly characterized. Some published cases suggest a potential post-exposure role of the vaccine in JORRP, but prospective multicentric trials are still needed.
authors.affiliation: Division of Pediatric Infectious Diseases and Vaccinology, Department of Pediatrics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
authors.forename: Laurent
authors.initials: L
authors.lastname: Yi
authors.affiliation: Division of Pediatric Infectious Diseases and Vaccinology, Department of Pediatrics, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
authors.forename: Bernard
authors.initials: B
authors.lastname: Vaudaux
authors.affiliation: Division of Pediatric Airway Surgery, Department of Otorhinolaryngology - Head & Neck Surgery, Lausanne University Hospital, Lausanne, Switzerland; Department of Otorhinlaryngology, Hôpital de Sion - CHCVs/RSV, Av. Grand Champsec 80, 1950 Sion, Switzerland.
authors.forename: Kishore
authors.initials: K
authors.lastname: Sandu
authors.affiliation: Department of Otorhinlaryngology, Hôpital de Sion - CHCVs/RSV, Av. Grand Champsec 80, 1950 Sion, Switzerland. Electronic address: llnisa@yahoo.ca.
authors.forename: Lluís
authors.initials: L
authors.lastname: Nisa
mesh_terms: D002648:Child; D006801:Humans; D008297:Male; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D053918:Papillomavirus Vaccines / Q000008:administration & dosage*; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery
chemical_list: D053918:Papillomavirus Vaccines
keywords: Anti-HPV vaccine; Juvenile-onset recurrent respiratory papillomatosis