title: "Strategic sequences" in adipose-derived stem cell nerve regeneration.
abstract: BACKGROUND
  Peripheral nerve injuries (PNI) are a major source of morbidity worldwide. The development of cellular regenerative therapies has the potential to improve outcomes of nerve injuries. However, an ideal therapy has yet to be found. The purpose of this study is to examine the current literature key points of regenerative techniques using human adipose-derived stem cells (hADSCs) for nerve regeneration and derive a comprehensive approach to hADSC therapy for PNI.
  
  
  METHODS
  A literature review was conducted using the electronic database PubMed to search for current experimental approaches to repairing PNI using hADSCs. Key search elements focused on specific components of nerve regeneration paradigms, including (1) support cells, (2) scaffolds, and (3) nerve conduits.
  
  
  RESULTS
  Strategic sequences were developed by optimizing the components of different experimental regenerative therapies. These sequences focus on priming hADSCs within a specialized growth medium, a hydrogel matrix base, and a collagen nerve conduit to achieve neuromodulatory nerve regeneration. hADSCs may exert their neuroregenerative influence through paracrine effects on surrounding Schwann cells in addition to physical interactions with injured tissue.
  
  
  CONCLUSIONS
  hADSCs may play a key role in nerve regeneration by acting primarily as support for local neurotrophic mediation and modulation of nerve growth rather than that of a primary neuronal differentiation agent.
authors.affiliation: Department of Aesthetic and Plastic Surgery, University of California, Irvine, CA.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Widgerow
authors.forename: Ara A
authors.initials: AA
authors.lastname: Salibian
authors.forename: Emil
authors.initials: E
authors.lastname: Kohan
authors.forename: Tadeu
authors.initials: T
authors.lastname: Sartiniferreira
authors.forename: Hassaan
authors.initials: H
authors.lastname: Afzel
authors.forename: Thanh
authors.initials: T
authors.lastname: Tham
authors.forename: Gregory R D
authors.initials: GR
authors.lastname: Evans
mesh_terms: D017667:Adipocytes / Q000637:transplantation*; D006801:Humans; D009416:Nerve Regeneration; D059348:Peripheral Nerve Injuries / Q000601:surgery*; D033581:Stem Cell Transplantation; D054457:Tissue Scaffolds