title: An age-related decline of CD62L and vaccine response: a role of microRNA 92a?
abstract: Aging process can affect T cell and antibody response to vaccination and an age-related decline in the expression of CD62L on CD8(+) T-lymphocyte is one of the important factors that contribute. A recent report demonstrated that percentage of CD3(+)CD8(+)CD62L(+) cells and CD8(+) T-lymphocyte microRNA-92a levels significantly decline with the age and were positively correlated. These results suggested that the age-related attrition of human naïve T cells could be connected to a reduced microRNA-92a in T-lymphocytes and downregulation of the microRNA-92a level might indicate exhaustion of naïve T-cells due to alteration of the immunologic condition with aging. Further studies are necessary to evaluate whether targeting microRNA-92a as microRNA mimics could be one of the therapeutic strategies in improving vaccine response in elderly.
authors.affiliation: Department of Pediatrics; Yonsei University College of Medicine; Seoul, Korea.
authors.forename: Jae Il
authors.initials: JI
authors.lastname: Shin
authors.affiliation: Institut National de la Santé et de la Recherche Médicale; Unité 1138; Paris, France; Centre de Recherche des Cordeliers; Equipe 16- Immunopathology and therapeutic immunointervention; Université Pierre et Marie Curie - Paris 6; Paris, France; Université Paris Descartes; Paris, France.
authors.forename: Jagadeesh
authors.initials: J
authors.lastname: Bayry
mesh_terms: D000375:Aging / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D019041:L-Selectin / Q000502:physiology*; D008297:Male
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D019041:L-Selectin
keywords: CD62L; CD8+ T-lymphocyte; immunosenescence; microRNA 92a; vaccine response