title: Congenital glioblastoma coexisting with vascular developmental anomaly.
abstract: Congenital central nervous tumours form a unique group of neoplasms. They are different from other tumour groups not only due to the onset time but also to their histopathology, anatomic location, and biologic behaviour. Congenital glioblastoma is one of the rarest types of congenital brain tumours and is uncommon in the prenatal period. We report a rare case of congenital glioblastoma detected prenatally by ultrasound examination and magnetic resonance imaging at 26 gestational weeks. Based on MRI findings and consultation of a team of specialists, pregnancy was terminated at 28 weeks. The newborn presented hydrops foetal. The child died shortly after birth due to cardiorespiratory insufficiency. At autopsy a large tumour with a spongy-like appearance was found. The tumour involved nearly the whole right cerebral hemisphere and led to marked hydrocephalus. In the histological and immunohistochemical examination, the tumour presented features of glioblastoma. Neoplastic cells were immunopositive for GFAP, S-100 protein and negative for neuronal markers. Frequent mitoses and high MIB-1 labelling index were seen in the tumour areas. The coexistence of tumour and vascular developmental anomaly was stated. The conglomerates of numerous, distended, thin-walled foetal-like blood vessels were located beside the tumour tissue, which presented disturbance in differentiation and maturation of the vascular net. Such coexistence of malignant glioma with vascular developmental anomaly is unique.
authors.affiliation: Milena Laure-Kamionowska, MD, PhD, Department of Experimental and Clinical Neuropathology, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St., 02-106 Warsaw, Poland, e-mail: mkamionowska@imdik.pan.pl.
authors.forename: Milena
authors.initials: M
authors.lastname: Laure-Kamionowska
authors.forename: Krystyna
authors.initials: K
authors.lastname: Szymanska
authors.forename: Monika
authors.initials: M
authors.lastname: Biekiesinska-Figatowska
authors.forename: Barbara
authors.initials: B
authors.lastname: Gierowska-Bogusz
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Michalak
authors.forename: Teresa
authors.initials: T
authors.lastname: Klepacka
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis*; D020785:Central Nervous System Vascular Malformations / Q000150:complications* / Q000175:diagnosis*; D017809:Fatal Outcome; D005260:Female; D005909:Glioblastoma / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods