title: Associations of the antioxidant capacity and hemoglobin levels with functional physical performance of the upper and lower body limbs.
abstract: Herein we considered the role of oxidative stress on deficiencies of functional physical performance that could affect a future pre-frailty condition. Using principal component analyses (PCA), we created new variables to better describe the functionality regarding the physical performance of the upper and lower body limbs. Gait speed and the Short Physical Performance Battery (SPPB) score were classified by PCA to describe functional performance of the lower body limbs. Variables describing the general physical status, including weekly consumption of kilocalories and the musculoskeletal index, were classified together with grip strength of the dominant hand as indicators of functional performance of the upper body limbs. An intimate association between the functional physical performance of the upper body limbs and the total antioxidant capacity was observed in older subjects. Low levels of total antioxidant capacity were found in women 76 years or younger with deficiencies in the physical performance of both upper and lower body limbs. Similarly, we observed a close association between the functional physical performance of the lower body limbs and the levels of hemoglobin. In particular, low levels of hemoglobin were mostly found in men older than 76 years of age, showing impaired functional physical performance. In addition, the physical performance of the lower body limbs was shown to be more important than that of the upper body limbs in the statistical association with pre-frailty in the elderly. Therefore, specific low levels of hemoglobin and deficient oxidative defense in the elderly could significantly affect the functional physical performance and future outcomes of pre-frailty.
authors.affiliation: Department ofvMorphology and Cellular Biology, Faculty of Medicine, University of Oviedo, C/ Julián Clavería s/n, 33006, Oviedo, Spain, bea1979c@hotmail.com.
authors.forename: Beatriz
authors.initials: B
authors.lastname: Caballero
authors.forename: Adrián
authors.initials: A
authors.lastname: Rubio-González
authors.forename: Yaiza
authors.initials: Y
authors.lastname: Potes
authors.forename: Marta
authors.initials: M
authors.lastname: Martínez-Reig
authors.forename: Pedro Manuel
authors.initials: PM
authors.lastname: Sánchez-Jurado
authors.forename: Luis
authors.initials: L
authors.lastname: Romero
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Solano
authors.forename: Pedro
authors.initials: P
authors.lastname: Abizanda
authors.forename: Ana
authors.initials: A
authors.lastname: Coto-Montes
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D018737:Hand Strength / Q000502:physiology*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D035002:Lower Extremity / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D018384:Oxidative Stress; D010809:Physical Fitness / Q000502:physiology*; D034941:Upper Extremity / Q000502:physiology*
chemical_list: D000975:Antioxidants; D006454:Hemoglobins