title: Left ventricular myocardial dyssynchrony is already present in nondiabetic patients with metabolic syndrome.
abstract: The presence of left ventricular (LV) dyssynchrony in individuals with metabolic syndrome (MetS), a predictor of type 2 diabetes (T2D), lacks clarity. We compared LV dyssynchrony in MetS individuals with and without T2D, and healthy control subjects using speckle-tracking imaging echocardiography. Ninety-two MetS participants (64 without, 28 with T2D) and 40 control subjects underwent echocardiographic and clinical/biological analyses. LV-dyssynchrony in the longitudinal axis only was present in all MetS individuals, but was not further exacerbated by T2D. Strong associations were found with systemic inflammation, abdominal obesity, and LV mass. Investigations of myocardial dyssynchrony in the nondiabetic MetS stage might facilitate timely and more effective prevention.
authors.affiliation: EA4278, LAPEC, Avignon University, Avignon, France; School of Exercise Science, Australian Catholic University, Fitzroy, Australia.
authors.forename: Edward
authors.initials: E
authors.lastname: Crendal
authors.affiliation: EA4278, LAPEC, Avignon University, Avignon, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Walther
authors.affiliation: School of Exercise Science, Australian Catholic University, Fitzroy, Australia; EA3533, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Blaise Pascal University, Clermon-Ferrand, France; Occupational Medicine, University Hospital CHU G, Montpied, Clermon-Ferrand, France.
authors.forename: Fred
authors.initials: F
authors.lastname: Dutheil
authors.affiliation: School of Exercise Science, Australian Catholic University, Fitzroy, Australia; EA3533, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Blaise Pascal University, Clermon-Ferrand, France.
authors.forename: Daniel
authors.initials: D
authors.lastname: Courteix
authors.affiliation: EA3533, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Blaise Pascal University, Clermon-Ferrand, France; Geriatrics, PRES Clermont University of Auvergne, Clermon-Ferrand, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Lesourd
authors.affiliation: EA3533, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (AME2P), Blaise Pascal University, Clermon-Ferrand, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Chapier
authors.affiliation: School of Exercise Science, Australian Catholic University, Fitzroy, Australia.
authors.forename: Geraldine
authors.initials: G
authors.lastname: Naughton
authors.affiliation: EA4278, LAPEC, Avignon University, Avignon, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Vinet
authors.affiliation: EA4278, LAPEC, Avignon University, Avignon, France; School of Exercise Science, Australian Catholic University, Fitzroy, Australia. Electronic address: philippe.obert@univ-avignon.fr.
authors.forename: Philippe
authors.initials: P
authors.lastname: Obert
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D018450:Disease Progression; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D009200:Myocardial Contraction; D011379:Prognosis; D012720:Severity of Illness Index; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D015415:Biomarkers