title: Systems mapping of genes controlling chemotherapeutic drug efficiency for cancer stem cells.
abstract: Cancer can be controlled effectively by using chemotherapeutic drugs to inhibit cancer stem cells, but there is considerable inter-patient variability regarding how these cells respond to drug intervention. Here, we describe a statistical framework for mapping genes that control tumor responses to chemotherapeutic drugs as well as the efficacy of treatments in arresting tumor growth. The framework integrates the mathematical aspects of the cancer stem cell hypothesis into genetic association studies, equipped with a capacity to quantify the magnitude and pattern of genetic effects on the kinetic decline of cancer stem cells in response to therapy. By quantifying how specific genes and their interactions govern drug response, the model provides essential information to tailor personalized drugs for individual patients.
authors.affiliation: Center for Computational Biology, Beijing Forestry University, Beijing 100083, China.
authors.forename: Weimiao
authors.initials: W
authors.lastname: Wu
authors.affiliation: Center for Computational Biology, Beijing Forestry University, Beijing 100083, China.
authors.forename: Sisi
authors.initials: S
authors.lastname: Feng
authors.affiliation: Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA.
authors.forename: Yaqun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA.
authors.forename: Ningtao
authors.initials: N
authors.lastname: Wang
authors.affiliation: Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA.
authors.forename: Han
authors.initials: H
authors.lastname: Hao
authors.affiliation: Center for Computational Biology, Beijing Forestry University, Beijing 100083, China; Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA. Electronic address: rwu@bjfu.edu.cn.
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002874:Chromosome Mapping / Q000379:methods; D005796:Genes / Q000235:genetics*; D056726:Genetic Association Studies / Q000379:methods; D006801:Humans; D007206:Individuality; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D057285:Precision Medicine / Q000379:methods
chemical_list: D000970:Antineoplastic Agents