title: Fermentative succinate production: an emerging technology to replace the traditional petrochemical processes.
abstract: Succinate is a valuable platform chemical for multiple applications. Confronted with the exhaustion of fossil energy resources, fermentative succinate production from renewable biomass to replace the traditional petrochemical process is receiving an increasing amount of attention. During the past few years, the succinate-producing process using microbial fermentation has been made commercially available by the joint efforts of researchers in different fields. In this review, recent attempts and experiences devoted to reduce the production cost of biobased succinate are summarized, including strain improvement, fermentation engineering, and downstream processing. The key limitations and challenges faced in current microbial production systems are also proposed.
authors.affiliation: CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
authors.forename: Yujin
authors.initials: Y
authors.lastname: Cao
authors.affiliation: CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
authors.forename: Rubing
authors.initials: R
authors.lastname: Zhang
authors.affiliation: CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Sun
authors.affiliation: CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Cheng
authors.affiliation: CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Liu
authors.affiliation: CAS Key Laboratory of Bio-Based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
authors.forename: Mo
authors.initials: M
authors.lastname: Xian
mesh_terms: D018533:Biomass; D010578:Petroleum; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development*; D013386:Succinates / Q000737:chemistry* / Q000378:metabolism
chemical_list: D010578:Petroleum; D013386:Succinates