title: Genomics AIDS lung tumor classification and treatment.
abstract: Analysis of 1,255 lung tumors compared the accuracy of genetic sequencing versus immunohistochemistry in tumor classification and found that the genetic methods allow more accurate assigning of tumors to therapeutically relevant groups, particularly for large cell carcinoma. A subsequent prospective research effort using the project's combined genomic and immunohistochemical diagnostic approach screened 5,145 lung cancer patients for a panel of roughly 20 lung cancer mutations. The authors were able to perform the combined genomic and immunohistochemical analysis on 3,863 patients, and many of them were eligible for approved targeted therapies or for treatment with experimental therapies in clinical trials.
mesh_terms: D023281:Genomics; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000145:classification* / Q000188:drug therapy / Q000235:genetics