title: Locked-in syndrome after basilary artery thrombosis by mucormycosis masquerading as meningoencephalitis in a lymphoma patient.
abstract: Locked-in syndrome is a rare clinical syndrome due to basilary artery thrombosis generally associated with trauma, vascular, or cardiac malformation. It can present as various types of clinical evolution and occasionally masquerades as other pathological conditions, such as infective meningoencephalitis. These complications are the cause of diagnostic delay, if not promptly recognised, followed by patient death. We report the case of a 42-year-old female with a systemic B and cutaneous T-cell non-Hodgkin's lymphoma, with a severe neutropenia lasting over a year, who eventually developed a rapid and fatal fungal mucormycosis sepsis following a skin infection on her right arm, associated with locked-in syndrome and meningoencephalitis.
authors.affiliation: Division of Pathology, European Institute of Oncology, Milan 20141, Italy.
authors.forename: Fausto
authors.initials: F
authors.lastname: Maffini
authors.affiliation: Division of Haematoncology, European Institute of Oncology, Milan 20141, Italy.
authors.forename: Emilia
authors.initials: E
authors.lastname: Cocorocchio
authors.affiliation: Division of Pathology, European Institute of Oncology, Milan 20141, Italy.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Pruneri
authors.affiliation: Division of Radiology, European Institute of Oncology, Milan 20141, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Bonomo
authors.affiliation: Division of Haematoncology, European Institute of Oncology, Milan 20141, Italy.
authors.forename: Fedro
authors.initials: F
authors.lastname: Peccatori
authors.affiliation: Division of Pathology, European Institute of Oncology, Milan 20141, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Chiapparini
authors.affiliation: Division of Pathology, European Institute of Oncology, Milan 20141, Italy.
authors.forename: Silvia Di
authors.initials: SD
authors.lastname: Vincenzo
authors.affiliation: Division of Haematoncology, European Institute of Oncology, Milan 20141, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
authors.affiliation: Division of Pathology, European Institute of Oncology, Milan 20141, Italy ; University of Milan School of Medicine, Milan 20141, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Viale
keywords: cutaneous lymphomas; infectious disease; mucorales fungi; mycosis; oncology; stroke; thrombosis