title: Enhance, delete, incept: manipulating hippocampus-dependent memories.
abstract: Here we provide a brief overview of recent research on memory manipulation. We focus primarily on memories for which the hippocampus is thought to be required due to its central importance in the study of memory. The repertoire of methods employed is expanding and includes optogenetics, transcranial stimulation, deep brain stimulation, cued reactivation during sleep and the use of pharmacological agents. In addition, the possible mechanisms underlying these memory changes have been investigated using techniques such as single unit recording and functional magnetic resonance imaging (fMRI). This article is part of a Special Issue entitled 'Memory enhancement'.
authors.affiliation: Institute of Behavioural Neuroscience, Research Department of Cognitive, Perceptual and Brain Sciences, Division of Psychology and Language Sciences, University College London, 26 Bedford Way, London WC1H 0AP, UK. Electronic address: h.spiers@ucl.ac.uk.
authors.forename: Hugo J
authors.initials: HJ
authors.lastname: Spiers
authors.affiliation: Institute of Behavioural Neuroscience, Research Department of Cognitive, Perceptual and Brain Sciences, Division of Psychology and Language Sciences, University College London, 26 Bedford Way, London WC1H 0AP, UK. Electronic address: d.bendor@ucl.ac.uk.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bendor
mesh_terms: D000818:Animals; D046690:Deep Brain Stimulation; D005108:Extinction, Psychological / Q000502:physiology*; D006624:Hippocampus / Q000098:blood supply / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008568:Memory / Q000502:physiology*; D062308:Optogenetics; D012890:Sleep; D065908:Transcranial Direct Current Stimulation
keywords: Extinction; Fear conditioning; Hippocampus; Memory consolidation; Reconsolidation; Sleep