title: Anti-hepatitis C virus dinorditerpenes from the roots of Flueggea virosa.
abstract: Along with four known terpenoids (1-4), eight new dinorditerpenes (5-12) were isolated and identified from the roots of Flueggea virosa. The absolute configurations of 4-6 were determined by the Mosher's method, and that of 5 was confirmed by single-crystal X-ray diffraction analysis. Using the hepatitis C virus cell culture infection system, compounds 1, 3, 11, and 12 exhibited significant anti-HCV activity with EC50 values of 5.6, 5.0, 7.5, and 6.6 μM, respectively. Compounds 11 and 12 were nontoxic toward the tested Huh7.5 cell lines.
authors.affiliation: School of Pharmacy, China Medical University , Taichung 40402, Taiwan.
authors.forename: Chih-Hua
authors.initials: CH
authors.lastname: Chao
authors.forename: Ju-Chien
authors.initials: JC
authors.lastname: Cheng
authors.forename: De-Yang
authors.initials: DY
authors.lastname: Shen
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013624:Taiwan; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D004224:Diterpenes; D013729:Terpenes