title: Liver adenomatosis: serial investigation on MRI.
abstract: OBJECTIVE
  To describe the natural history of liver adenomatosis (LA), including complications and changes in lesion size over time.
  
  
  METHODS
  Eighteen patients with clinical diagnosis of LA were included. Clinical and biochemical information were collected. The initial and follow-up MR studies were reviewed retrospectively to determine change in lesion size and imaging features.
  
  
  RESULTS
  Seventeen patients were women (94.4%). The mean age of the initial MR study was 37.0 years (18-52 years). The median size of the largest lesion was 6.7 cm (range 3.0-13.5 cm). Intratumoral bleeding was detected on MRI in 9 lesions, in 7 patients (38.8%). The median size for hemorrhagic lesions was 7.6 cm (range 4.1-13.5 cm). During the mean follow-up period of 29.4 (range 4-98) months, 10 patients had stable disease (55.6%), and 8 patients had tumor regression (44.4%). Of 8 patients who were followed without intervention, 3 patients (37.5%) had spontaneous regression. No malignant transformation or lesion progression was occurred.
  
  
  CONCLUSIONS
  During an over 2-year follow-up period, the majority of lesions of LA appeared to remain stable or showed tumor regression. Spontaneous tumor regression can be observed in approximately 37% of individuals in the age range of 28-53 years.
authors.affiliation: Department of Radiology, University of North Carolina at Chapel Hill, Old Clinic Bldg, CB 7510 - 2001, Chapel Hill, NC, 27599-7510, USA.
authors.forename: Saowanee
authors.initials: S
authors.lastname: Srirattanapong
authors.forename: Wirana
authors.initials: W
authors.lastname: Angthong
authors.forename: Bong Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Paul Hideyo
authors.initials: PH
authors.lastname: Hayashi
authors.forename: David A
authors.initials: DA
authors.lastname: Gerber
authors.forename: John T
authors.initials: JT
authors.lastname: Woosley
authors.forename: Jared
authors.initials: J
authors.lastname: Peacock
authors.forename: Anuruddika
authors.initials: A
authors.lastname: Ranatunga
authors.forename: Richard C
authors.initials: RC
authors.lastname: Semelka
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives; D008875:Middle Aged; D009942:Organometallic Compounds; D012075:Remission, Spontaneous; D012189:Retrospective Studies
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C073590:gadolinium ethoxybenzyl DTPA; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA