title: One-day versus two-day cleansing for colon capsule endoscopy: a prospective randomized pilot study.
abstract: BACKGROUND
  Standard bowel cleansing for colon capsule endoscopy (CCE) requires a liquid diet and bowel laxatives for at least 2 days, which is a major drawback of this procedure and affects tolerance and acceptability.
  
  
  OBJECTIVE
  To compare the quality of colon cleanliness achieved with one-day versus two-day bowel preparation in outpatients undergoing CCE.
  
  
  METHODS
  Patients were randomly assigned to one of two groups: group I (one-day schedule, n=20) received a fiber-free diet and 3 L of polyethylene glycol (PEG) on day 0; group II (two-day schedule, n=20) received a liquid diet and 3 L of PEG in the evening of day -1, and 1L of PEG in the early morning of day 0. In both groups, the patients received 15 mg bisacodyl on day -1 and one or two additional sodium phosphate (NaP) boosters following capsule ingestion. Each colon segment was assessed for cleanliness using a four-point grading scale (excellent=1, good=2, fair=3, and poor=4). For the final analysis, colon cleanliness was rated as adequate (good or excellent) or inadequate (fair or poor).
  
  
  RESULTS
  Overall colon cleanliness was adequate in 94% (CI 91-97) of patients in group I versus 80% (CI 72-88) in group II (P=0.27). No significant differences were observed in the per-segment quality of colon cleansing between the two groups. CCE reached the rectum in 80% (CI 73-87) of patients in group I versus 75% (CI 67-83) in group II (p=0.59).
  
  
  CONCLUSIONS
  The quality of colon cleanliness achieved with one-day bowel preparation is equivalent to that of the standard two-day schedule in patients undergoing CCE.
authors.affiliation: Department of Gastroenterology, Hospital Universitario de Canarias, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Ramos
authors.affiliation: Department of Gastroenterology, Hospital Universitario de Canarias, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Spain.
authors.forename: Onofre
authors.initials: O
authors.lastname: Alarcón
authors.affiliation: Department of Gastroenterology, Hospital Universitario de Canarias, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Spain.
authors.forename: Zaida
authors.initials: Z
authors.lastname: Adrian
authors.affiliation: Department of Gastroenterology, Hospital Universitario de Canarias, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Spain.
authors.forename: Antonio Z
authors.initials: AZ
authors.lastname: Gimeno-García
authors.affiliation: Department of Gastroenterology, Hospital Universitario de Canarias, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Spain.
authors.forename: David
authors.initials: D
authors.lastname: Nicolás-Pérez
authors.affiliation: Research Unit, Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Jiménez-Sosa
authors.affiliation: Department of Gastroenterology, Hospital Universitario de Canarias, Facultad de Medicina, Universidad de La Laguna, La Laguna, Tenerife, Spain. Electronic address: equinter@gmail.com.
authors.forename: Enrique
authors.initials: E
authors.lastname: Quintero
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced; D000328:Adult; D000368:Aged; D001726:Bisacodyl / Q000008:administration & dosage* / Q000009:adverse effects; D053704:Capsule Endoscopy; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D003106:Colon; D004043:Dietary Fiber; D004294:Domperidone / Q000008:administration & dosage* / Q000009:adverse effects; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D010710:Phosphates / Q000008:administration & dosage* / Q000009:adverse effects; D010865:Pilot Projects; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D007507:Therapeutic Irrigation / Q000379:methods; D014839:Vomiting / Q000139:chemically induced
chemical_list: D002400:Cathartics; D004043:Dietary Fiber; D010710:Phosphates; D001726:Bisacodyl; D011092:Polyethylene Glycols; D004294:Domperidone; C018279:sodium phosphate
keywords: Colon capsule endoscopy; Colonic cleansing; Colonoscopia; Cápsula endoscópica de colon; Preparación colónica