title: G protein-coupled receptors as regulators of glucose homeostasis and therapeutic targets for diabetes mellitus.
abstract: As critical regulators of almost all physiological processes in the body, G protein-coupled receptors (GPCRs) are important regulators of glucose homeostasis. Some of the newer drugs for treating diabetes mellitus or in development are also targeting GPCRs. This chapter provides a summary of some of the GPCRs that have been shown to be involved in regulating glucose homeostasis.
authors.affiliation: Department of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, Alabama, USA.
authors.forename: Ya-Xiong
authors.initials: YX
authors.lastname: Tao
authors.affiliation: College of Fisheries, Key Lab of Freshwater Animal Breeding, Ministry of Agriculture, Huazhong Agricultural University, Wuhan, Hubei, China.
authors.forename: Xu-Fang
authors.initials: XF
authors.lastname: Liang
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism* / Q000628:therapy*; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D058990:Molecular Targeted Therapy; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D007328:Insulin; D043562:Receptors, G-Protein-Coupled; D005947:Glucose
keywords: G protein-coupled receptor; Glucose homeostasis; Incretin; Neuropeptides; Pancreatic peptide