title: Mechanical analysis of arterial plaques in native geometry with OCT wall motion analysis.
abstract: The mechanical behavior of an atherosclerotic plaque may encode information about the type, composition, and vulnerability to rupture. Human arterial segments with varying plaque burden were analyzed ex vivo with optical coherence tomography (OCT) to determine plaque type and to determine compliance during pulsatile inflation in their native geometry. Calcifications and lipid filled plaques showed markedly different compliance when analyzed with OCT wall motion analysis. There was also a trend towards increased circumferential variation in arterial compliance with increasing plaque burden.
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, 2121 Engineering Hall, Irvine, CA 92617, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, USA.
authors.forename: Claire
authors.initials: C
authors.lastname: Robertson
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, 2121 Engineering Hall, Irvine, CA 92617, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, USA; Beckman Laser Institute, University of California, Irvine, CA 92617, USA.
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Heidari
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, 2121 Engineering Hall, Irvine, CA 92617, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, USA; Beckman Laser Institute, University of California, Irvine, CA 92617, USA.
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, 2121 Engineering Hall, Irvine, CA 92617, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, USA; Department of Chemical Engineering, University of California, Irvine, CA 92617, USA; Department of Medicine, University of California, Irvine, CA 92617, USA. Electronic address: scgeorge@uci.edu.
authors.forename: Steven C
authors.initials: SC
authors.lastname: George
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002102:Cadaver; D002114:Calcinosis / Q000473:pathology* / Q000503:physiopathology; D003187:Compliance; D005260:Female; D005263:Femoral Artery / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D058226:Plaque, Atherosclerotic / Q000473:pathology* / Q000503:physiopathology; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult
keywords: Atherosclerotic plaque; Compliance; Optical coherence tomography