title: Mannose-binding lectin polymorphisms and the risk of sepsis: evidence from a meta-analysis.
abstract: Several studies have evaluated the association between mannose-binding lectin (MBL) polymorphisms and sepsis. However, the results are inconclusive and conflicting. To better understand the roles of MBL polymorphisms in sepsis, we conducted a comprehensive meta-analysis. All relevant studies were searched from PubMed, EMBASE and Web of Knowledge databases, with the last report up to 7 May 2013. Twenty-nine studies addressing four MBL polymorphisms (-550G/C, -221G/C, structure variant A/O, Gly54Asp) were analysed for susceptibility to sepsis and one study for sepsis-related mortality. Overall, significant associations between structure variant A/O and susceptibility to sepsis were observed for AO + OO vs. AA [odds ratio (OR) 1·27, 95% confidence interval (CI) 1·05-1·52, P = 0·01] and O vs. A (OR 1·19, 95% CI 1·02-1·40, P = 0·03). In subgroup analysis based on age group, increased risk was found in the paediatric group in the dominant model (OR 1·72, 95% CI 1·16-2·56, P = 0·007). Moreover, there was a slight association between the +54A/B polymorphism and susceptibility to sepsis in Caucasians (recessive model: OR 10·64, 95% CI 1·24-91·65, P = 0·03). However, no association was observed for -550G/C and -221G/C polymorphisms both overall and in subgroup analysis. For sepsis-related mortality, only one study suggested AO/OO was associated with in-hospital mortality in pneumococcal sepsis patients after controlling for confounding variables. Our meta-analysis indicated that MBL structure variants might be associated with susceptibility to sepsis but further studies with a large sample size should be conducted to confirm these findings.
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury,Institute of Surgery Research, Daping Hospital, Third Military Medical University,Chongqing,China.
authors.forename: A-Q
authors.initials: AQ
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury,Institute of Surgery Research, Daping Hospital, Third Military Medical University,Chongqing,China.
authors.forename: C-L
authors.initials: CL
authors.lastname: Yue
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury,Institute of Surgery Research, Daping Hospital, Third Military Medical University,Chongqing,China.
authors.forename: W
authors.initials: W
authors.lastname: Pan
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury,Institute of Surgery Research, Daping Hospital, Third Military Medical University,Chongqing,China.
authors.forename: J-W
authors.initials: JW
authors.lastname: Gao
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury,Institute of Surgery Research, Daping Hospital, Third Military Medical University,Chongqing,China.
authors.forename: L
authors.initials: L
authors.lastname: Zeng
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury,Institute of Surgery Research, Daping Hospital, Third Military Medical University,Chongqing,China.
authors.forename: W
authors.initials: W
authors.lastname: Gu
authors.affiliation: State Key Laboratory of Trauma, Burns and Combined Injury,Institute of Surgery Research, Daping Hospital, Third Military Medical University,Chongqing,China.
authors.forename: J-X
authors.initials: JX
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000367:Age Factors; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D037601:Mannose-Binding Lectin / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D018805:Sepsis / Q000235:genetics* / Q000401:mortality
chemical_list: D037601:Mannose-Binding Lectin