title: Cerebral vein thrombosis in a four year old with Behçet's disease.
abstract: Behçet's disease (BD) is a multisystem disorder. The main pathology in BD is vasculitis that involves arteries and veins of all calibers. Central nervous system involvement occurs in 5-10% of patients. Increased morbidity and mortality is rarely observed in children. The mean age at onset in pediatric BD is approximately 7 years. Neurologic involvement in BD is usually observed after 3-6 years. We report the case of a four-year-old Turkish boy with BD with sagittal sinus thrombosis treated with infliximab. The patient presented papilledema without neurologic signs. Although long-term efficacy evaluations are needed in this case, infliximab therapy may be a good option in childhood BD with refractory sinus thrombosis. This is the youngest case of BD with sagittal sinus thrombosis reported so far.
authors.affiliation: Gulhane Military Medical Academy, Medicine School, Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology, Turkey. Electronic address: duyguovunc@yahoo.com.tr.
authors.forename: Duygu Ovunc
authors.initials: DO
authors.lastname: Hacihamdioglu
authors.affiliation: Gulhane Military Medical Academy, Medicine School, Department of Pathology, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Demiriz
authors.affiliation: Gulhane Military Medical Academy, Medicine School, Department of Ophtalmology, Turkey.
authors.forename: Gungor
authors.initials: G
authors.lastname: Sobaci
authors.affiliation: Gulhane Military Medical Academy, Medicine School, Department of Radiology, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Kocaoglu
authors.affiliation: Gulhane Military Medical Academy, Medicine School, Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology, Turkey.
authors.forename: Erkan
authors.initials: E
authors.lastname: Demirkaya
authors.affiliation: Gulhane Military Medical Academy, Medicine School, Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology, Turkey.
authors.forename: Faysal
authors.initials: F
authors.lastname: Gok
mesh_terms: D001528:Behcet Syndrome / Q000150:complications*; D002550:Cerebral Veins; D002675:Child, Preschool; D006801:Humans; D020767:Intracranial Thrombosis / Q000209:etiology*; D008297:Male
keywords: Behçet's disease; Children; Enfermedad de Behçet's; Infliximab; Niños; Thrombosis; Trombosis