title: Polymeric delivery systems for dexamethasone.
abstract: Glucocorticoids (GCs) are broadly used in the treatment of inflammation and in suppressing hyperactivity of the immune system expressed in allergies, asthma, autoimmune diseases and sepsis. They are pleiotropic in nature, showing a wide range of diverse effects, including those which are harmful for the organism. Dexamethasone (DEX) is one of the most frequently used GCs and is considered as one of the safest. Still serious side-effects have been observed for this drug, mostly due to its hydrophobicity and low bioavailability. The potentially promising polymeric carrier systems to deliver DEX effectively are revised.
authors.affiliation: Faculty of Chemistry, Jagiellonian University, 30-060 Kraków, Ingardena 3, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Urbańska
authors.affiliation: Faculty of Chemistry, Jagiellonian University, 30-060 Kraków, Ingardena 3, Poland. Electronic address: karewicz@chemia.uj.edu.pl.
authors.forename: Anna
authors.initials: A
authors.lastname: Karewicz
authors.affiliation: Faculty of Chemistry, Jagiellonian University, 30-060 Kraków, Ingardena 3, Poland.
authors.forename: Maria
authors.initials: M
authors.lastname: Nowakowska
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D003907:Dexamethasone / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D005128:Eye Diseases / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000893:Anti-Inflammatory Agents; D011108:Polymers; D003907:Dexamethasone
keywords: Carrier; Drug; Glucocorticoids