title: Hemodynamic responses with different dose of ketamine and propofol in day care gynecological surgeries.
abstract: BACKGROUND
  Day care gynaecological surgeries mandate use of hemodynamically stable combination of commonly used intravenous agents, propofol & ketamine. Hence we proposed to evaluate the hemodynamic profile of different dose combination of propofol & ketamine as induction agents in ambulatory gynecological surgeries.
  
  
  METHODS
  Thirty adult patients scheduled for day care gynecological surgeries were randomly divided into five Groups. Group I received inj. propofol 2mg/kg i.v + inj. Normal saline (NS); Group II received ketamine 2mg/kg i.v + inj. NS; Group III was given inj. Propofol 2mg/kg i.v followed by inj. Ketamine 1 mg/kg i.v.; Group IV received inj. Ketamine 2 mg/kg i.v followed by inj. propofol 1 mg/kg i.v; Group V received combination of inj. Propofol 1 mg/kg i.v and inj. Ketamine 1 mg/kg i.v. After administration of the drug, non invasive systolic, diastolic and mean arterial pressures, heart rate, respiratory rate, arterial oxygen saturation and ECG were recorded every minute for five minutes.
  
  
  RESULTS
  Statistically significant hemodynamic alterations were observed in Group I & II, with Group I having the highest incidence of apnea (23.3%). No significant changes in hemodynamics were seen in Group V.
  
  
  CONCLUSIONS
  We conclude that the combination of 1mg Propofol and 1mg ketamine produced better hemodynamic stability in comparison to other Groups.
authors.affiliation: Assistant Professor, Department of Anaesthesia, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Kamakshi
authors.initials: K
authors.lastname: Garg
authors.affiliation: Assistant Professor, Department of Anaesthesia, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Gurpreeti
authors.initials: G
authors.lastname: Grewal
authors.affiliation: Professor, Department of Anaesthesia, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Anju
authors.initials: A
authors.lastname: Grewal
authors.affiliation: Professor (Retd.), Department of Anaesthesia, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Avtar
authors.initials: A
authors.lastname: Singh
authors.affiliation: Professor, Department of Surgery, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Atul
authors.initials: A
authors.lastname: Mishra
authors.affiliation: Assistant Professor, Department of Surgery, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Amandeep Singh
authors.initials: AS
authors.lastname: Nar
authors.affiliation: Assistant Professor, Department of Surgery, Dayanand Medical College and Hospital , Ludhiana, India .
authors.forename: Ashvind
authors.initials: A
authors.lastname: Bawa
keywords: Day care gynecological surgeries; Hemodynamic profile; Ketamine; Propofol