title: Interferon-regulatory factors determine macrophage phenotype polarization.
abstract: The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-regulatory factors are intracellular signaling elements that determine the maturation and gene transcription of leukocytes. Here we discuss how several among the 9 interferon-regulatory factors contribute to macrophage polarization.
authors.affiliation: Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstraße 1, 80336 München, Germany.
authors.forename: Roman
authors.initials: R
authors.lastname: Günthner
authors.affiliation: Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstraße 1, 80336 München, Germany.
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Anders
mesh_terms: D000818:Animals; D016764:Cell Polarity; D016207:Cytokines / Q000502:physiology; D006801:Humans; D050835:Interferon Regulatory Factors / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D010641:Phenotype
chemical_list: D016207:Cytokines; D050835:Interferon Regulatory Factors