title: [Expression of thyroid stimulating hormone receptor in differentiated thyroid carcinoma and its clinical significance].
abstract: OBJECTIVE
  To explore the expression of thyroid stimulating hormone (TSH) receptor in differentiated thyroid carcinoma and its clinical significance.
  
  
  METHODS
  Seventy-four patients with differentiated thyroid carcinoma treated in our department from January 2009 to January 2011 were selected as the observation group, and 28 patients with nodular goiter were selected as the control group. Expression of TSH receptor in the two groups were detected by immunohistochemistry.
  
  
  RESULTS
  The positive rate of TSH receptor expression in the observation group was 55.4 (41/74), significantly lower than that of the control group (89.3%, 25/28), with a significant difference between the two groups (χ(2) = 10.21, P < 0.05). In the observation group, the positive rate of TSH receptor expression was 75.9% (22/29) in the stage I patients, 47.8% (11/23) in the stage II patients, 38.9%6 (7/18) in the stage III patients, and 25.0% (1/4) in the stage IV patients. Along with the increase of TNM staging, the positive rate of TSH receptor expression was decreased gradually, with a significant difference between them (χ(2) = 8.93, P < 0.05). The positive rate of TSH receptor expression was 53.8% (14/26) in the lymph node metastasis positive group and 56.3% (27/48) in the lymph node metastasis negative groups, with a non-significant difference between them (χ(2) = 0.04, P > 0.05).
  
  
  CONCLUSIONS
  Expression of TSH receptors in the patients with differentiated thyroid carcinoma is quite low, and along with the increase of TNM staging, its positive rate is decreasing gradually. Testing the expression of TSH receptor may provide a basis for TSH suppression therapy after thyroid cancer surgery. This TSH suppression therapy should be personalized in order to reduce the side effects and improve their quality of life.
authors.affiliation: Department of Breast and Thyroid Surgery, Hebei Medical University Second Hospital, Shijiazhuang 050017, China. Email: liqh4011@163.com.
authors.forename: Qing-huai
authors.initials: QH
authors.lastname: Li
authors.affiliation: Department of Breast and Thyroid Surgery, Hebei Medical University Second Hospital, Shijiazhuang 050017, China.
authors.forename: Xiao-juan
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Department of Breast and Thyroid Surgery, Hebei Medical University Second Hospital, Shijiazhuang 050017, China.
authors.forename: Xiao-yu
authors.initials: XY
authors.lastname: Li
authors.affiliation: Department of Breast and Thyroid Surgery, Hebei Medical University Second Hospital, Shijiazhuang 050017, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Di
authors.affiliation: Department of Breast and Thyroid Surgery, Hebei Medical University Second Hospital, Shijiazhuang 050017, China.
authors.forename: Lin-lei
authors.initials: LL
authors.lastname: Zhang
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000378:metabolism / Q000473:pathology; D000328:Adult; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011989:Receptors, Thyrotropin / Q000378:metabolism*; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D011989:Receptors, Thyrotropin