title: Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics.
abstract: This work illustrates a two-step strategy for the fabrication of polymer/drug nanoparticles. Utilizing solvent/non-solvent precipitation and gaseous basification, composite nanoparticles with 0-100% drug loadings are fabricated. Drug release kinetics are dictated by nanoparticle composition allowing future tuning for therapeutic applications.
authors.affiliation: Institute for Regenerative Engineering, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA; Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA; Department of Orthopaedic Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
authors.forename: Bret D
authors.initials: BD
authors.lastname: Ulery
authors.forename: Ho-Man
authors.initials: HM
authors.lastname: Kan
authors.forename: Bryce A
authors.initials: BA
authors.lastname: Williams
authors.forename: Balaji
authors.initials: B
authors.lastname: Narasimhan
authors.forename: Kevin W-H
authors.initials: KW
authors.lastname: Lo
authors.forename: Lakshmi S
authors.initials: LS
authors.lastname: Nair
authors.forename: Cato T
authors.initials: CT
authors.lastname: Laurencin
mesh_terms: D000577:Amides / Q000737:chemistry / Q000378:metabolism; D000777:Anesthetics / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D053758:Nanoparticles / Q000737:chemistry* / Q000378:metabolism; D059408:Pain Management; D010316:Particle Size; D049388:Polyanhydrides / Q000737:chemistry*; D000077212:Ropivacaine; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000577:Amides; D000777:Anesthetics; D049388:Polyanhydrides; D014867:Water; D000077212:Ropivacaine
keywords: anesthetics; nanoparticles; pain management; polymers