title: Common marmoset as a new model animal for neuroscience research and genome editing technology.
abstract: The common marmoset (Callithrix jacchus) is a small New World primate; it originally comes from the Atlantic coastal forests in northeastern Brazil. It has been attracting much attention in the biomedical research field because of its size, availability, and unique biological characteristics. Its endocrinological and behavioral similarity to humans, comparative ease in handling, and high reproductive efficiency are very advantageous for neuroscience research. Recently, we developed transgenic common marmosets with germline transmission, and this technological breakthrough provides a potential paradigm shift by enabling researchers to investigate complex biological phenomena using genetically-modified non-human primates. In this review, we summarize recent progress in marmoset research, and also discuss a potential application of genome editing tools that should be useful toward the generation of knock-out/knock-in marmoset models.
authors.affiliation: Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan; RIKEN-Keio University Joint Research Laboratory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kishi
authors.forename: Kenya
authors.initials: K
authors.lastname: Sato
authors.forename: Erika
authors.initials: E
authors.lastname: Sasaki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Okano
mesh_terms: D000818:Animals; D002144:Callithrix / Q000235:genetics*; D018390:Gene Targeting / Q000379:methods*; D005818:Genetic Engineering / Q000379:methods*; D016678:Genome / Q000235:genetics*; D023421:Models, Animal; D009488:Neurosciences / Q000379:methods*; D012106:Research
keywords: clustered regularly interspaced short palindromic repeat/Cas9; common marmoset; genome editing; transcription activator-like effector nuclease; zinc finger nuclease