title: Poly-ε-caprolactone tungsten oxide nanoparticles as a contrast agent for X-ray computed tomography.
abstract: Inorganic nanomaterials based on heavy elements represent a new class of contrast agents for X-ray computed tomography (CT). Recent advances have shown that these materials are highly suited for CT imaging due to their high density and X-ray absorption capabilities. In this contribution, we demonstrated that tungsten oxide (WO3) nanoparticles coated by poly-ε-caprolactone (PCL) can be used as efficient contrast agent for CT imaging. The obtained particles were characterized by electron microscopy (TEM and SEM), and dynamic light scattering (DLS). We also validated their use for enhanced in vivo imaging, since these nanoparticles were observed to display high X-ray attenuation properties and circulation time (up to 3 h), permitting blood pool imaging.
authors.affiliation: University of Strasbourg, Faculty of Pharmacy, 74 Route du Rhin, 67401 Illkirch, France; CNRS 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, 67401 Illkirch, France.
authors.forename: Anshuman
authors.initials: A
authors.lastname: Jakhmola
authors.affiliation: University of Strasbourg, Faculty of Pharmacy, 74 Route du Rhin, 67401 Illkirch, France; CNRS 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, 67401 Illkirch, France. Electronic address: nanton@unistra.fr.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Anton
authors.affiliation: University of Strasbourg, Faculty of Pharmacy, 74 Route du Rhin, 67401 Illkirch, France; CNRS 7213, Laboratoire de Biophotonique et Pharmacologie, 67401 Illkirch, France.
authors.forename: Halina
authors.initials: H
authors.lastname: Anton
authors.affiliation: Institute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS/INSERM/Collège de France, Illkirch, France.
authors.forename: Nadia
authors.initials: N
authors.lastname: Messaddeq
authors.affiliation: Université Lyon-1, F-69622 Villeurbanne, France; CNRS UMR 5007, Laboratoire d'Automatique et de Génie des Procédés (LAGEP), F-69622 Villeurbanne, France.
authors.forename: François
authors.initials: F
authors.lastname: Hallouard
authors.affiliation: University of Strasbourg, Faculty of Pharmacy, 74 Route du Rhin, 67401 Illkirch, France; CNRS 7213, Laboratoire de Biophotonique et Pharmacologie, 67401 Illkirch, France.
authors.forename: Andrey
authors.initials: A
authors.lastname: Klymchenko
authors.affiliation: University of Strasbourg, Faculty of Pharmacy, 74 Route du Rhin, 67401 Illkirch, France; CNRS 7213, Laboratoire de Biophotonique et Pharmacologie, 67401 Illkirch, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Mely
authors.affiliation: University of Strasbourg, Faculty of Pharmacy, 74 Route du Rhin, 67401 Illkirch, France; CNRS 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, 67401 Illkirch, France.
authors.forename: Thierry F
authors.initials: TF
authors.lastname: Vandamme
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects; D003287:Contrast Media; D006367:HeLa Cells; D006801:Humans; D057446:Hydrodynamics; D051379:Mice; D053758:Nanoparticles / Q000633:toxicity / Q000648:ultrastructure; D010087:Oxides / Q000633:toxicity; D010316:Particle Size; D011091:Polyesters / Q000633:toxicity; D014057:Tomography, X-Ray Computed; D014414:Tungsten / Q000633:toxicity; D055114:X-Ray Microtomography; D014965:X-Rays
chemical_list: D003287:Contrast Media; D010087:Oxides; D011091:Polyesters; C016240:polycaprolactone; C511604:tungsten oxide; D014414:Tungsten
keywords: Contrast agent; Micro-CT; Nanoparticles; Preclinical imaging; Tungsten oxide; X-ray imaging