title: Effects of Lycopersicon esculentum extract on hair growth and alopecia prevention.
abstract: To evaluate the potential hair growth-promoting activity and the expression of cell growth factors of Lycopersicon esculentum extracts, each 3% (w/w) of ethyl acetate extract (EAE), and supercritical CO2 extract (SCE) of L. esculentum and isolated lycopene Tween 80 solution (LTS) and test hair tonic (THT) containing LTS were applied on the dorsal skin of C57BL/6 mice, once a day for 4 weeks. At week 4, LTS and THT exhibited hair growth-promoting potential similar to that of 3% minoxidil as a positive control (PC). Further, in the LTS group, a significant increase of mRNA expression of vascular endothelial growth factor (VEGF), keratinocyte growth factor, and insulin-like growth factor-1 (IGF-1) was observed than PC, as well as the negative control (NC). In the THT group, increases in IGF-1 and decrease in VEGF and transforming growth factor-β expression were significant over the NC. In a histological examination in the THT group, the induction of anagen stage of hair follicles was faster than that of NC. In the Draize skin irritation study for THT, no observable edema or erythema was observed on all four sectors in the back skin after exposure for 24 or 72 h for any rabbit. Therefore, this study provides reasonable evidence that L. esculentum extracts promote hair growth and suggests that applications could be found in hair loss treatments without skin irritation at moderate doses.
authors.affiliation: RIS Center, IACF Silla University, Busan 617-736, Republic of Korea (J.-S.C., I.S.C.), Department of Dermatology, Korea University Ansan Hospital, Ansan 425-701, Republic of Korea (S.K.J., Y.-H.J., S.W.S.), Department of R&D, Ecomine Co., Ltd, Busan 608-736, Republic of Korea (M.-H.J., J.-N.M., W.-S.M.), Department of Biological Science, Silla University, Busan 617-736, Republic of Korea (I.S.C.).
authors.forename: Jae-Suk
authors.initials: JS
authors.lastname: Choi
authors.affiliation: RIS Center, IACF Silla University, Busan 617-736, Republic of Korea (J.-S.C., I.S.C.), Department of Dermatology, Korea University Ansan Hospital, Ansan 425-701, Republic of Korea (S.K.J., Y.-H.J., S.W.S.), Department of R&D, Ecomine Co., Ltd, Busan 608-736, Republic of Korea (M.-H.J., J.-N.M., W.-S.M.), Department of Biological Science, Silla University, Busan 617-736, Republic of Korea (I.S.C.).
authors.forename: Sung Kyu
authors.initials: SK
authors.lastname: Jung
authors.affiliation: RIS Center, IACF Silla University, Busan 617-736, Republic of Korea (J.-S.C., I.S.C.), Department of Dermatology, Korea University Ansan Hospital, Ansan 425-701, Republic of Korea (S.K.J., Y.-H.J., S.W.S.), Department of R&D, Ecomine Co., Ltd, Busan 608-736, Republic of Korea (M.-H.J., J.-N.M., W.-S.M.), Department of Biological Science, Silla University, Busan 617-736, Republic of Korea (I.S.C.).
authors.forename: Min-Hee
authors.initials: MH
authors.lastname: Jeon
authors.affiliation: RIS Center, IACF Silla University, Busan 617-736, Republic of Korea (J.-S.C., I.S.C.), Department of Dermatology, Korea University Ansan Hospital, Ansan 425-701, Republic of Korea (S.K.J., Y.-H.J., S.W.S.), Department of R&D, Ecomine Co., Ltd, Busan 608-736, Republic of Korea (M.-H.J., J.-N.M., W.-S.M.), Department of Biological Science, Silla University, Busan 617-736, Republic of Korea (I.S.C.).
authors.forename: Jin-Nam
authors.initials: JN
authors.lastname: Moon
authors.affiliation: RIS Center, IACF Silla University, Busan 617-736, Republic of Korea (J.-S.C., I.S.C.), Department of Dermatology, Korea University Ansan Hospital, Ansan 425-701, Republic of Korea (S.K.J., Y.-H.J., S.W.S.), Department of R&D, Ecomine Co., Ltd, Busan 608-736, Republic of Korea (M.-H.J., J.-N.M., W.-S.M.), Department of Biological Science, Silla University, Busan 617-736, Republic of Korea (I.S.C.).
authors.forename: Woi-Sook
authors.initials: WS
authors.lastname: Moon
authors.affiliation: RIS Center, IACF Silla University, Busan 617-736, Republic of Korea (J.-S.C., I.S.C.), Department of Dermatology, Korea University Ansan Hospital, Ansan 425-701, Republic of Korea (S.K.J., Y.-H.J., S.W.S.), Department of R&D, Ecomine Co., Ltd, Busan 608-736, Republic of Korea (M.-H.J., J.-N.M., W.-S.M.), Department of Biological Science, Silla University, Busan 617-736, Republic of Korea (I.S.C.).
authors.forename: Yi-Hwa
authors.initials: YH
authors.lastname: Ji
authors.affiliation: RIS Center, IACF Silla University, Busan 617-736, Republic of Korea (J.-S.C., I.S.C.), Department of Dermatology, Korea University Ansan Hospital, Ansan 425-701, Republic of Korea (S.K.J., Y.-H.J., S.W.S.), Department of R&D, Ecomine Co., Ltd, Busan 608-736, Republic of Korea (M.-H.J., J.-N.M., W.-S.M.), Department of Biological Science, Silla University, Busan 617-736, Republic of Korea (I.S.C.).
authors.forename: In Soon
authors.initials: IS
authors.lastname: Choi
authors.affiliation: RIS Center, IACF Silla University, Busan 617-736, Republic of Korea (J.-S.C., I.S.C.), Department of Dermatology, Korea University Ansan Hospital, Ansan 425-701, Republic of Korea (S.K.J., Y.-H.J., S.W.S.), Department of R&D, Ecomine Co., Ltd, Busan 608-736, Republic of Korea (M.-H.J., J.-N.M., W.-S.M.), Department of Biological Science, Silla University, Busan 617-736, Republic of Korea (I.S.C.).
authors.forename: Sang
authors.initials: S
authors.lastname: Wook Son
mesh_terms: D000085:Acetates / Q000737:chemistry; D000279:Administration, Cutaneous; D000505:Alopecia / Q000235:genetics / Q000378:metabolism / Q000517:prevention & control*; D000818:Animals; D002245:Carbon Dioxide / Q000737:chemistry; D002338:Carotenoids / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D051523:Fibroblast Growth Factor 7 / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D018859:Hair Follicle / Q000187:drug effects* / Q000254:growth & development; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000378:metabolism; D000077276:Lycopene; D018551:Solanum lycopersicum / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008914:Minoxidil / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry; D011817:Rabbits; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012997:Solvents / Q000737:chemistry; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism
chemical_list: D000085:Acetates; C496454:Fgf7 protein, mouse; D010936:Plant Extracts; D011136:Polysorbates; D012997:Solvents; D042461:Vascular Endothelial Growth Factor A; C467480:vascular endothelial growth factor A, mouse; D051523:Fibroblast Growth Factor 7; D002245:Carbon Dioxide; D002338:Carotenoids; D008914:Minoxidil; D007334:Insulin-Like Growth Factor I; C007650:ethyl acetate; D000077276:Lycopene