title: Hypoglycemic activity of Ficus racemosa bark in combination with oral hypoglycemic drug in diabetic human.
abstract: Medicinal herbs, used in indigenous medicines in crude forms for the management of diabetes mellitus, contain both the organic and inorganic constituents. The aim of the study was to find out the hypoglycemic effect of Ficus racemosa in a group of diabetic subjects taking oral hypoglycemic drug. Twenty five of each, male and female, diabetic patients, selected from Fatima Jinnah Medical College, Lahore, Pakistan, taking oral hypoglycemic drug were included in this study and were given orally the extract (5 mL) of bark of Ficus racemosa (about 100 mg) two times for 15 days. Blood samples for estimation of blood glucose and parameters of liver and renal functions were estimated. It was observed that after taking the herb in combination with drug, blood glucose level (fasting and after breakfast) was markedly decreased in both male and female but significant difference was only observed in sugar level of males after 1.5 h after breakfast. To rule out herb toxicity, liver and renal functions tests of patients was also performed which were observed to be in normal range. Present investigation established a pharmacological evidence to support the folklore claim that Ficus racemosa is good anti-diabetic agent.
authors.affiliation: Department of Biochemistry, Fatima Jinnah Medical College, Lahore 54000, Pakistan.
authors.lastname: Gul-e-Rana
authors.affiliation: College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan.
authors.forename: Sabiha
authors.initials: S
authors.lastname: Karim
authors.affiliation: Department of Biochemistry, Fatima Jinnah Medical College, Lahore 54000, Pakistan.
authors.forename: Rukhshan
authors.initials: R
authors.lastname: Khurhsid
authors.affiliation: College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan.
authors.forename: Syed
authors.initials: S
authors.lastname: Saeed-ul-Hassan
authors.affiliation: College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan.
authors.forename: Imran
authors.initials: I
authors.lastname: Tariq
authors.affiliation: College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan.
authors.forename: Misbah
authors.initials: M
authors.lastname: Sultana
authors.affiliation: Pacific Pharmaceuticals, Multan Road, Lahore 54000, Pakistan.
authors.forename: Ahmad Junaid
authors.initials: AJ
authors.lastname: Rashid
authors.affiliation: Department of Statistics, University of Balochistan, Quetta, Pakistan.
authors.forename: Syed Haider
authors.initials: SH
authors.lastname: Shah
authors.affiliation: Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
authors.forename: Ghulam
authors.initials: G
authors.lastname: Murtaza
mesh_terms: D000284:Administration, Oral; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D030681:Ficus / Q000737:chemistry; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D010154:Pakistan; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects / Q000302:isolation & purification; D010946:Plants, Medicinal; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts