title: Mismatch negativity: translating the potential.
abstract: The mismatch negativity (MMN) component of the auditory event-related potential has become a valuable tool in cognitive neuroscience. Its reduced size in persons with schizophrenia is of unknown origin but theories proposed include links to problems in experience-dependent plasticity reliant on N-methyl-d-aspartate glutamate receptors. In this review we address the utility of this tool in revealing the nature and time course of problems in perceptual inference in this illness together with its potential for use in translational research testing animal models of schizophrenia-related phenotypes. Specifically, we review the reasons for interest in MMN in schizophrenia, issues pertaining to the measurement of MMN, its use as a vulnerability index for the development of schizophrenia, the pharmacological sensitivity of MMN and the progress in developing animal models of MMN. Within this process we highlight the challenges posed by knowledge gaps pertaining to the tool and the pharmacology of the underlying system.
authors.affiliation: School of Psychology, University of Newcastle , Callaghan, NSW , Australia ; Priority Research Centre for Brain and Mental Health, University of Newcastle , Callaghan, NSW , Australia ; Schizophrenia Research Institute , Darlinghurst, NSW , Australia ; Hunter Medical Research Institute , Newcastle, NSW , Australia.
authors.forename: Juanita
authors.initials: J
authors.lastname: Todd
authors.affiliation: School of Psychology, University of Newcastle , Callaghan, NSW , Australia ; Priority Research Centre for Brain and Mental Health, University of Newcastle , Callaghan, NSW , Australia ; Schizophrenia Research Institute , Darlinghurst, NSW , Australia ; Hunter Medical Research Institute , Newcastle, NSW , Australia.
authors.forename: Lauren
authors.initials: L
authors.lastname: Harms
authors.affiliation: Priority Research Centre for Brain and Mental Health, University of Newcastle , Callaghan, NSW , Australia ; Schizophrenia Research Institute , Darlinghurst, NSW , Australia ; Hunter Medical Research Institute , Newcastle, NSW , Australia ; School of Medicine and Public Health, University of Newcastle , Callaghan, NSW , Australia.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schall
authors.affiliation: School of Psychology, University of Newcastle , Callaghan, NSW , Australia ; Priority Research Centre for Brain and Mental Health, University of Newcastle , Callaghan, NSW , Australia ; Schizophrenia Research Institute , Darlinghurst, NSW , Australia ; Hunter Medical Research Institute , Newcastle, NSW , Australia.
authors.forename: Patricia T
authors.initials: PT
authors.lastname: Michie
keywords: NMDA; NMDAR; auditory event-related potential; mismatch negativity; schizophrenia; synaptic plasticity