title: Interleukin-10 may protect against progressing injury during the acute phase of ischemic stroke.
abstract: Atherosclerosis is an inflammatory disease, and ischemic stroke is one of its most common and devastating manifestations. Proinflammatory cytokines play a key role in the progression of the irreversible ischemic lesions. The presence of anti-inflammatory mediators may prevent secondary ischemic injury.
  
  
  OBJECTIVE
  1) To assess the relationship between stroke severity and the serum levels of IL-1β, IL-2, and IL-10; and 2) To analyze the neurological outcome after 72 h of ischemic stroke onset and expression of interleukins.
  
  
  METHODS
  We measured the serum levels of IL-1β, IL-2, and IL-10 in 26 patients with acute stroke. Neurological impairment was scored using the National Institute of Health Stroke Scale within the first 72 h after stroke onset. Thirty healthy subjects were analyzed as controls.
  
  
  RESULTS
  Patients with IL-10 <925.0 pg/mL presented with neurological deterioration within the first 72 h.
  
  
  CONCLUSIONS
  IL-10 may protect against ischemic injury during the acute phase of stroke.
authors.affiliation: Emergency Service, Department of Medicine.
authors.forename: Gustavo G
authors.initials: GG
authors.lastname: Protti
authors.affiliation: Neurology Division, Department of Medicine.
authors.forename: Rubens J
authors.initials: RJ
authors.lastname: Gagliardi
authors.affiliation: Immunology Division, Department of Pathological Sciences.
authors.forename: Wilma C N
authors.initials: WC
authors.lastname: Forte
authors.affiliation: Emergency Service, Department of Medicine.
authors.forename: Sandra Regina S
authors.initials: SR
authors.lastname: Sprovieri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000517:prevention & control*; D016022:Case-Control Studies; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D053583:Interleukin-1beta / Q000097:blood*; D007376:Interleukin-2 / Q000097:blood*; D002537:Intracranial Arteriosclerosis / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood* / Q000209:etiology; D013997:Time Factors
chemical_list: D053583:Interleukin-1beta; D007376:Interleukin-2; D016753:Interleukin-10