title: [Radiofrequency ablation for liver metastases from colorectal cancer after systemic chemotherapy].
abstract: OBJECTIVE
  To evaluate the effectiveness and safety of radiofrequency ablation(RFA)for liver metastases from colorectal cancer after chemotherapy.
  
  
  METHODS
  From January 2006 to June 2012, 27 tumors in 17 patients with liver metastases from colorectal cancer were treated using RFA after systemic chemotherapy.
  
  
  RESULTS
  The median tumor diameter after chemotherapy was 12(range: 3-35)mm, and the mean number of tumors was 1.6(range: 1-4).The median time without local recurrence was 21.3(range: 2.2-61.9)months, and the median overall survival time was 38.0(range: 5.9-66.3)months. One patient had a complication(liver abscess).Of the 27 tumors, 9 were larger than 20 mm in diameter, and 4 of these 9 tumors showed local recurrence after RFA. In tumors smaller than 20 mm in diameter, only 1 showed local recurrence. The local recurrence rate was significantly higher for tumors larger than 20 mm than for tumors smaller than 20 mm(44.4% vs 5.6%,p=0.030).
  
  
  CONCLUSIONS
  RFA was an effective and safe method for treating liver metastases from colorectal cancer, especially for tumors smaller than 20 mm and in cases of less than 3 tumors after systemic chemotherapy.
authors.affiliation: Dept. of Gastroenterological Surgery, Graduate School of Medicine, Osaka University.
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Owada
authors.forename: Kohei
authors.initials: K
authors.lastname: Murata
authors.forename: Koji
authors.initials: K
authors.lastname: Mikami
authors.forename: Shu
authors.initials: S
authors.lastname: Okamura
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Ide
authors.forename: Yuma
authors.initials: Y
authors.lastname: Wada
authors.forename: Ryo
authors.initials: R
authors.lastname: Kato
authors.forename: Shunichiro
authors.initials: S
authors.lastname: Makino
authors.forename: Takahiko
authors.initials: T
authors.lastname: Nishigaki
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Okada
authors.forename: Nariaki
authors.initials: N
authors.lastname: Fukuchi
authors.forename: Chikara
authors.initials: C
authors.lastname: Ebisui
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Kinuta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017115:Catheter Ablation; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012008:Recurrence; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents