title: [A case in which XELOX plus bevacizumab chemotherapy was effective in an elderly patient with heart failure and multiple liver metastases after sigmoidectomy].
abstract: A 75-year-old woman with a chief complain of anal pain visited the emergency department. She was diagnosed as having S-colon cancer perforation accompanied by an intra-abdominal abscess. Computed tomography (CT)-guided drainage was applied to the intra-abdominal abscess. Six days after drainage, the patient's condition progressed to acute respiratory failure due to heart failure, and ventilator support was provided temporarily. The patient's cardiopulmonary function improved with conservative management. S-colon cancer was detected during colonoscopy examination, and biopsy indicated a tub2 tumor. Next, S-colon resection with D3 lymph node dissection was performed. The postoperative course was uncomplicated. Two months after surgery, liver metastases were detected on CT. Since the patient's performance status (PS) was 3, it was impossible for her to undergo chemotherapy. Four months after surgery, her PS was restored to 2 and the liver metastases were exacerbated, as seen on CT. The patient began chemotherapy (XELOX plus bevacizumab, 30% reduced dose). Eight months after the start of chemotherapy, 9 courses had been administered, the carcinoembryonic antigen (CEA)/carbohydrate antigen (CA) 19-9 level had decreased to the reference value, and the decrease in size of the liver metastases indicated a partial response (PR), as assessed by CT.
authors.affiliation: Dept. of Surgery, Hasuda Hospital.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Matsui
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Aoyagi
authors.forename: Kumi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Jun
authors.initials: J
authors.lastname: Kaneko
authors.forename: Shizuaki
authors.initials: S
authors.lastname: Maejima
authors.forename: Jun
authors.initials: J
authors.lastname: Isogai
mesh_terms: D018784:Abdominal Abscess / Q000209:etiology; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D000068258:Bevacizumab; D000069287:Capecitabine; D003082:Colectomy; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D006333:Heart Failure / Q000150:complications*; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D010071:Oxaloacetates; D012811:Sigmoid Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D010071:Oxaloacetates; D003841:Deoxycytidine; D000068258:Bevacizumab; D000069287:Capecitabine; D005472:Fluorouracil