title: [A case of curatively resected locally advanced pancreatic cancer with combined resection of the portal vein and common hepatic artery after neoadjuvant chemotherapy].
abstract: A man in his 40s had a locally advanced pancreatic head cancer invading the portal vein( PV) and common hepatic artery (CHA). He underwent 5 courses of neoadjuvant chemotherapy( gemcitabine+S-1), which reduced the tumor volume and cancer antigen 19-9 (CA19-9) level. R0 resection was performed via sub-stomach preserving pancreatoduodenectomy with combined resection of the PV and CHA. Adjuvant chemotherapy with gemcitabine was administered at 4 weeks after the operation. Relevant neoadjuvant chemotherapy is considered to contribute to R0 resection of locally advanced pancreatic cancer. Here, we report a case of a successful R0 resection after neoadjuvant chemotherapy for locally advanced pancreatic cancer.
authors.affiliation: Division of Hepato-Biliary-Pancreatic Surgery, Tohoku University Hospital.
authors.forename: Kei
authors.initials: K
authors.lastname: Kawaguchi
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Motoi
authors.forename: Satoru
authors.initials: S
authors.lastname: Yokoyama
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takemura
authors.forename: Takashi
authors.initials: T
authors.lastname: Doi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nozawa
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Fujishima
authors.forename: Michiaki
authors.initials: M
authors.lastname: Unno
authors.forename: Fusakuni
authors.initials: F
authors.lastname: Kuroda
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004338:Drug Combinations; D006499:Hepatic Artery / Q000601:surgery*; D006801:Humans; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D011169:Portal Vein / Q000601:surgery*; D005641:Tegafur / Q000008:administration & dosage; D000093542:Gemcitabine
chemical_list: D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine