title: Human parechovirus infection, Denmark.
abstract: Human parechoviruses (HPeVs) often cause severe illness among young children. National surveillance with routine testing of all cerebrospinal fluid, fecal, and tissue samples was conducted during January 2009-December 2012 in all counties in Denmark (6,817 samples from 4,804 children were screened for HPeV). We detected HPeV RNA in 202 (3.0%) specimens from 149 persons. Young infants were at highest risk for HPeV, and 9 (6%) of the HPeV-infected children died, probably of their HPeV illness. HPeV3 was the most common genotype identified, and 5 closely related clades of HPeV3 circulated in Denmark throughout the study period. Our study adds perspective on the prevalence and clinical and molecular virologic characteristics of HPeV infection.
authors.forename: Thea K
authors.initials: TK
authors.lastname: Fischer
authors.forename: Sofie
authors.initials: S
authors.lastname: Midgley
authors.forename: Camilla
authors.initials: C
authors.lastname: Dalgaard
authors.forename: Alex Y
authors.initials: AY
authors.lastname: Nielsen
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008969:Molecular Sequence Data; D030061:Parechovirus / Q000145:classification* / Q000235:genetics*; D010802:Phylogeny; D010850:Picornaviridae Infections / Q000453:epidemiology*; D011159:Population Surveillance; D015995:Prevalence; D012367:RNA, Viral; D012621:Seasons; D055815:Young Adult
chemical_list: D012367:RNA, Viral
keywords: Denmark; HPeV; children; infants; meningitis; parechovirus; phylogenetic; viruses