title: Baseline characteristics of patients with heart failure and preserved ejection fraction included in the Karolinska Rennes (KaRen) study.
abstract: BACKGROUND
  Karolinska Rennes (KaRen) is a prospective observational study to characterize heart failure patients with preserved ejection fraction (HFpEF) and to identify prognostic factors for long-term mortality and morbidity.
  
  
  OBJECTIVE
  To report characteristics and echocardiography at entry and after 4-8 weeks of follow-up.
  
  
  METHODS
  Patients were included following an acute heart failure presentation with B-type natriuretic peptide (BNP)>100 ng/L or N-terminal pro-BNP (NT-proBNP)>300 ng/L and left ventricular ejection fraction (LVEF)>45%.
  
  
  RESULTS
  The mean ± SD age of 539 included patients was 77 ± 9 years and 56% were women. Patient history included hypertension (78%), atrial tachyarrhythmia (44%), prior heart failure (40%) and anemia (37%), but left bundle branch block was rare (3.8%). Median NT-proBNP was 2448 ng/L (n=438), and median BNP 429 ng/L (n=101). Overall, 101 patients did not return for the follow-up visit, including 13 patients who died (2.4%). Apart from older age (80 ± 9 vs. 76 ± 9 years; P=0.006), there were no significant differences in baseline characteristics between patients who did and did not return for follow-up. Mean LVEF was lower at entry than follow-up (56% vs. 62%; P<0.001). At follow-up, mean E/e' was 12.9 ± 6.1, left atrial volume index 49.4±17.8mL/m(2). Mean global left ventricular longitudinal strain was -14.6 ± 3.9%; LV mass index was 126.6 ± 36.2g/m(2).
  
  
  CONCLUSIONS
  Patients in KaRen were old with slight female dominance and hypertension as the most prevalent etiological factor. LVEF was preserved, but with increased LV mass and depressed LV diastolic and longitudinal systolic functions. Few patients had signs of electrical dyssynchrony (ClinicalTrials.gov.- NCT00774709).
authors.affiliation: Département de Cardiologie & CIC-IT U 804, Hôpital Pontchaillou, CHU de Rennes, rue Henri-Le-Guillou, 35000 Rennes, France; LTSI, Université Rennes 1, INSERM 1099, Rennes, France; Société française de cardiologie, Paris, France. Electronic address: erwan.donal@chu-rennes.fr.
authors.forename: Erwan
authors.initials: E
authors.lastname: Donal
authors.affiliation: Department of Medicine, Karolinska Institutet and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden; Société française de cardiologie, Paris, France.
authors.forename: Lars H
authors.initials: LH
authors.lastname: Lund
authors.affiliation: Clinical Investigation Center INSERM CIC-0203, CHU de Rennes, Rennes, France; Société française de cardiologie, Paris, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Oger
authors.affiliation: Department of Medicine, Karolinska Institutet and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden; Société française de cardiologie, Paris, France.
authors.forename: Camilla
authors.initials: C
authors.lastname: Hage
authors.affiliation: Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Stockholm, Sweden; Société française de cardiologie, Paris, France.
authors.forename: Hans
authors.initials: H
authors.lastname: Persson
authors.affiliation: LTSI, Université Rennes 1, INSERM 1099, Rennes, France; Société française de cardiologie, Paris, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Reynaud
authors.affiliation: Service de Cardiologie, CHU de Lille, Lille, France; Société française de cardiologie, Paris, France.
authors.forename: Pierre-Vladimir
authors.initials: PV
authors.lastname: Ennezat
authors.affiliation: Département de Cardiologie, CHU de Rouen, Rouen, France; Société française de cardiologie, Paris, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bauer
authors.affiliation: Département de Cardiologie, CHU de Montpellier, Montpellier, France; Société française de cardiologie, Paris, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Sportouch-Dukhan
authors.affiliation: Département de Cardiologie, CHU de Montpellier, Montpellier, France; Société française de cardiologie, Paris, France.
authors.forename: Elodie
authors.initials: E
authors.lastname: Drouet
authors.affiliation: Département de Cardiologie & CIC-IT U 804, Hôpital Pontchaillou, CHU de Rennes, rue Henri-Le-Guillou, 35000 Rennes, France; LTSI, Université Rennes 1, INSERM 1099, Rennes, France; Société française de cardiologie, Paris, France.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Daubert
authors.affiliation: Department of Medicine, Karolinska Institutet and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden; Société française de cardiologie, Paris, France.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Linde
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005602:France / Q000453:epidemiology; D006333:Heart Failure / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D013318:Stroke Volume; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Caractéristiques cliniques; Clinical characteristics; Echocardiographic characteristics; Heart failure with preserved ejection fraction; Insuffisance cardiaque à fraction d’éjection préservée; Registre; Registry; Échocardiographie