title: Impact of infusion set characteristics on the accuracy of patient-controlled morphine administration: a controlled in-vitro study.
abstract: The aim of our in-vitro study was to assess the impact of infusion set characteristics on the accuracy of morphine doses in patient-controlled analgesia. Two infusion sets differing in conception and dead-space volume were assessed: a standard set and a low dead-space volume Y-set. The patient-controlled analgesia programme parameters were as follows: bolus equal to 1 ml at 100 ml.h(-1) ; lockout intervals equal to 5 and 10 min; and carrier fluid flow rate equal to 10 and 50 ml.h(-1) . Morphine concentration was determined by an ultraviolet spectrophotometric method. The morphine doses were significantly different from one set to the other during bolus and lockout intervals, whatever the patient-controlled analgesia programme. The average doses were approximately 1.3-6.0 times higher with the low dead-space volume Y-set during bolus. Our study underlines the impact of infusion set characteristics on the accuracy of morphine patient-controlled analgesia doses.
authors.affiliation: Department of Biopharmacy, Galenic and Hospital Pharmacy, Lille 2 University, UDSL, EA GRIIOT, UFR Pharmacie, Lille, France.
authors.forename: A
authors.initials: A
authors.lastname: Foinard
authors.forename: B
authors.initials: B
authors.lastname: Décaudin
authors.forename: C
authors.initials: C
authors.lastname: Barthélémy
authors.forename: G
authors.initials: G
authors.lastname: Lebuffe
authors.forename: B
authors.initials: B
authors.lastname: Debaene
authors.forename: P
authors.initials: P
authors.lastname: Odou
mesh_terms: D016058:Analgesia, Patient-Controlled / Q000295:instrumentation* / Q000379:methods; D000701:Analgesics, Opioid / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004867:Equipment Design; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous; D009020:Morphine / Q000008:administration & dosage*; D015203:Reproducibility of Results; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine