title: [Study on dosage form design for improving oral bioavailability of traditional Chinese medicines].
abstract: Both chemical drugs and traditional Chinese medicines have the problem of low bioavailability. However, as traditional Chinese medicines are a multi-component complex, their dosage forms are required to be designed in line with their characteristics, in order to improve the bioavailability of traditional Chinese medicines. Traditional Chinese medicines are mostly prepared into pill, powder, paste, elixir and decoction, but with such drawbacks as high administration dose and poor efficacy. With the process of modernization of traditional Chinese medicines, new-type preparations have be developed and made outstanding achievements. However, they fail to make an organic integration between traditional Chinese medicine theories and modern preparation theories. Characteristics of traditional Chinese medicines are required to be taken into account during the development of traditional Chinese medicines. In the article, multi-component preparation technology was adopted to establish a multi-component drug release system of traditional Chinese medicines on the basis of multiple components of traditional Chinese medicines.
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210046, China. haij-1988@163.com
authors.forename: Hai-Jian
authors.initials: HJ
authors.lastname: Xia
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Dong-Dong
authors.initials: DD
authors.lastname: Yao
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210046, China.
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Jia
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004304:Dosage Forms / Q000592:standards*; D016503:Drug Delivery Systems / Q000379:methods*; D004358:Drug Therapy; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans
chemical_list: D004304:Dosage Forms; D004365:Drugs, Chinese Herbal