title: [A case of emphysematous cholecystitis during the course of chemotherapy for gastric cancer].
abstract: A 77-year-old woman with Stage IV gastric cancer was admitted to our hospital because of high fever, poor appetite, and abdominal pain during combined chemotherapy with S-1 and cisplatin( CDDP). Abdominal computed tomography (CT) revealed the presence of gas in the submucosal layer on the basis of which emphysematous cholecystitis (EC) was diagnosed. We performed cholecystectomy and were able to proceed with the chemotherapy 1 month after surgery. Destruction of the gallbladder mucosa by ischemia has been reported to be a possible cause of emphysematous cholecystitis. Moreover, underlying systemic diseases such as arterial sclerosis and diabetes mellitus could be risk factors for EC. Our case suggested that chemotherapeutic agents might trigger ischemic changes in the gallbladder and thus result in EC.
authors.affiliation: Dept. of Surgical Oncology, Osaka City University Graduate School of Medicine.
authors.forename: Kenji
authors.initials: K
authors.lastname: Kuroda
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Amano
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Lee
authors.forename: Masaichi
authors.initials: M
authors.lastname: Ohira
authors.forename: Kazuya
authors.initials: K
authors.lastname: Muguruma
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kubo
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Sakurai
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kimura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Nagahara
authors.forename: Eiji
authors.initials: E
authors.lastname: Noda
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Maeda
authors.forename: Kosei
authors.initials: K
authors.lastname: Hirakawa
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D004338:Drug Combinations; D041882:Emphysematous Cholecystitis / Q000139:chemically induced / Q000601:surgery*; D005260:Female; D006801:Humans; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005641:Tegafur / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin