title: A male patient who developed late-onset primary biliary cirrhosis presenting with antinuclear envelope antibodies.
abstract: Abstract An 81-year-old man who had previously shown high levels of alkaline phosphatase (ALP), γ-glutamyltransferase (GTP), and total bilirubin presented with acute liver damage. He was positive for serum anti-gp210 and anti-p62 antibodies, but negative for serum antimitochondrial antibody. A liver biopsy revealed massive interstitial fibrosis and pseudolobulus, which were compatible with a diagnosis of primary biliary cirrhosis (PBC) at Scheuer's stage 4. He was given ursodeoxycolic acid at 600 mg/day. However, his condition deteriorated, and he eventually died of hepatic insufficiency in a state of malnutrition. We hypothesize that the presence of anti-gp210 and anti-p62 complex protein antibodies, rather than that of antimitochondrial antibodies, was correlated with the progression of PBC in this particular case.
authors.affiliation: Keigu Clinic , 2-2 Ichibanishinaka-cho, Tsurumi-ku, Yokohama 230-0023 , Japan.
authors.forename: K
authors.initials: K
authors.lastname: Miyachi
authors.forename: T
authors.initials: T
authors.lastname: Horigome
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: S
authors.initials: S
authors.lastname: Irimajiri
authors.forename: M
authors.initials: M
authors.lastname: Shibata
authors.forename: K
authors.initials: K
authors.lastname: Asada
authors.forename: R W
authors.initials: RW
authors.lastname: Hankins