title: [Evaluation of false-negative lymph nodes diagnosed by fludeoxy glucose-positron emission tomography in cases of metastatic esophageal squamous cell carcinoma].
abstract: We have encountered many cases wherein the metastatic nest of esophageal squamous cell carcinoma occupied only a small space in the lymph nodes because of which computed tomography( CT) and fludeoxy glucose( FDG)-positron emission tomography( PET) could not detect the lymph node metastasis satisfactorily. The false-negative lymph nodes that were not detected by FDG-PET before surgery were smaller in diameter, rate of occupation, and area of occupation than the true-positive lymph nodes. The smallest area of the cancer nest in the true-positive group was 7.5 mm2, and therefore, it was reasonable to consider a 5-mm diameter area as the criteria for correct diagnosis by FDG-PET. Most of the false-negative lymph nodes with a large area of carcinoma were attached to the primary tumor; therefore, they could not be precisely identified. The detection of false-negative lymph nodes by FDG-PET was not precise because of increases in the quantity of stroma-like cells in poorly differentiated carcinomas and in fibrosis caused by neoadjuvant therapy in the lymph nodes.
authors.affiliation: Dept. of Frontier Surgery, Graduate School of Medicine, Chiba University.
authors.forename: Tsuguaki
authors.initials: T
authors.lastname: Kono
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tohma
authors.forename: Gaku
authors.initials: G
authors.lastname: Ohira
authors.forename: Hisashi
authors.initials: H
authors.lastname: Gunji
authors.forename: Kazuo
authors.initials: K
authors.lastname: Narushima
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Imanishi
authors.forename: Toru
authors.initials: T
authors.lastname: Tochigi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujishiro
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Hanaoka
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Akutsu
authors.forename: Masaya
authors.initials: M
authors.lastname: Uesato
authors.forename: Isamu
authors.initials: I
authors.lastname: Hoshino
authors.forename: Kentaro
authors.initials: K
authors.lastname: Murakami
authors.forename: Toru
authors.initials: T
authors.lastname: Shiratori
authors.forename: Hisahiro
authors.initials: H
authors.lastname: Matsubara
authors.forename: Shinichi
authors.initials: S
authors.lastname: Okazumi
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Shuto
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005188:False Negative Reactions; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography
chemical_list: D019788:Fluorodeoxyglucose F18