title: Effect of total motile sperm count in intra-uterine insemination on ongoing pregnancy rate.
abstract: In a descriptive retrospective cohort study, we determined the cumulative pregnancy rate for couples undergoing intra-uterine insemination (IUI) with at least one total motile sperm count (TMC) <1 million compared to couples with a TMC consistently >1 million. Eight hundred and ninety-five cycles in 273 couples were studied from 2006 to 2009. In 895 cycles, ovarian stimulation was performed through recFSH injections. IUI was scheduled 38 ± 2 h after the administration of HCG when at least one follicle measured >18 mm. The cumulative pregnancy rate according to the TMC was calculated. The cumulative pregnancy rate after four cycles of IUI was 17.3% in couples with at least one TMC <1 million and 25.5% in couples with a TMC consistently >1 million. It is concluded that the TMC does not significantly influence cumulative pregnancy rates after 4 IUI cycles. Couples with a low TMC could benefit from IUI. This could be considered before IVF.
authors.affiliation: Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands; Department of Obstetrics and Gynaecology, Bronovo Hospital, Den Haag, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Kleppe
authors.forename: M H
authors.initials: MH
authors.lastname: van Hooff
authors.forename: J P
authors.initials: JP
authors.lastname: Rhemrev
mesh_terms: D005260:Female; D006801:Humans; D007317:Insemination, Artificial, Homologous; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013076:Sperm Count; D013081:Sperm Motility / Q000502:physiology*
keywords: Intra-uterine insemination; pregnancy rate; semen quality