title: A direct approach to a 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine library.
abstract: The synthesis of 6-hetarylamino[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines is reported. The functionalized secondary amines were constructed via a K2CO3-mediated SNAr reaction of weakly basic hetarylamines with 3-(3,5-dimethylpyrazol-1-yl)[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines, which allowed displacement 3,5-dimethylpyrazolyl leaving group. Significantly, the reaction exhibited a broad substrate scope and proceeded in good yields.
authors.affiliation: N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences , Moscow 119991, RussianFederation.
authors.forename: Nadezhda V
authors.initials: NV
authors.lastname: Palysaeva
authors.forename: Katerina P
authors.initials: KP
authors.lastname: Kumpan
authors.forename: Marina I
authors.initials: MI
authors.lastname: Struchkova
authors.forename: Igor L
authors.initials: IL
authors.lastname: Dalinger
authors.forename: Aleksandr V
authors.initials: AV
authors.lastname: Kormanov
authors.forename: Nataly S
authors.initials: NS
authors.lastname: Aleksandrova
authors.forename: Victor M
authors.initials: VM
authors.lastname: Chernyshev
authors.forename: Dmitrii F
authors.initials: DF
authors.lastname: Pyreu
authors.forename: Kyrill Yu
authors.initials: KY
authors.lastname: Suponitsky
authors.forename: Aleksei B
authors.initials: AB
authors.lastname: Sheremetev