title: [Reduction of exercise-mediated endothelial dysfunction markers in sedentary adults with chronic spinal cord injury].
abstract: OBJECTIVE
  Recent studies have found increased markers of endothelial activation in men with chronic spinal cord injury. This study was conducted to determine the effects of arm-cranking exercise on endothelial dysfunction in male adults with chronic SCI.
  
  
  METHODS
  A prospective randomized study of 17 sedentary adult males with chronic SCI at or under T5 level. Nine performed a supervised exercise program at a moderate intensity (arm-cranking: 12 weeks, 3 sessions/week). Plasma levels of endothelin-1, soluble intercellular adhesion molecule type 1 (sICAM-1), and soluble vascular adhesion molecule type 1 (sVCAM-1) were assessed by ELISA. Outcome measurements also included physical fitness and total body fat mass percentage.
  
  
  RESULTS
  We observed both in the randomized and in the before-after studies a significant reduction of the levels of endothelin-1 and sICAM-1. Furthermore, significant improvements of both physical fitness and body composition were also found.
  
  
  CONCLUSIONS
  Arm-cranking exercise improved endothelial dysfunction in adult males with chronic SCI. Long-term studies are still required to determine whether the correction of endothelial dysfunction improves the clinical outcomes of adults with chronic SCI.
authors.affiliation: Departamento de Medicina, Universidad de Cádiz, Cádiz, España.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rosety-Rodriguez
authors.affiliation: Servicio de Medicina Interna, Hospital Juan Ramón Jiménez, Huelva, España.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Camacho-Molina
authors.affiliation: Escuela de Medicina del Deporte, Universidad de Cádiz, Cádiz, España.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rosety
authors.affiliation: Departamento de Medicina, Universidad de Cádiz, Cádiz, España.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Fornieles
authors.affiliation: Escuela de Medicina del Deporte, Universidad de Cádiz, Cádiz, España.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Rosety
authors.affiliation: Escuela de Medicina del Deporte, Universidad de Cádiz, Cádiz, España. Electronic address: franciscojavier.ordonez@uca.es.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Ordoñez
mesh_terms: D050154:Adiposity; D000328:Adult; D001132:Arm; D015415:Biomarkers; D001823:Body Composition; D019332:Endothelin-1 / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005081:Exercise Therapy; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D057185:Sedentary Behavior; D013119:Spinal Cord Injuries / Q000503:physiopathology / Q000534:rehabilitation / Q000628:therapy*; D016896:Treatment Outcome; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
keywords: Activación endotelial; Chronic spinal cord injury; Ejercicio; Endothelial activation; Endothelial function; Exercise; Función endotelial; Lesión medular crónica