title: Click chemistry plays a dual role in biodegradable polymer design.
abstract: Click chemistry plays a dual role in the design of new citrate-based biodegradable elastomers (CABEs) with greatly improved mechanical strength and easily clickable surfaces for biofunctionalization. This novel chemistry modification strategy is applicable to a number of different types of polymers for improved mechanical properties and biofunctionality.
authors.affiliation: Department of Biomedical Engineering, Materials Research Institute, The Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, PA, 16802, USA.
authors.forename: Jinshan
authors.initials: J
authors.lastname: Guo
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Xie
authors.forename: Richard T
authors.initials: RT
authors.lastname: Tran
authors.forename: Denghui
authors.initials: D
authors.lastname: Xie
authors.forename: Dadi
authors.initials: D
authors.lastname: Jin
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Bai
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D049109:Cell Proliferation; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002951:Citrates / Q000737:chemistry; D057930:Click Chemistry; D055119:Elastic Modulus; D020724:Elastomers / Q000737:chemistry*; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D011108:Polymers / Q000737:chemistry; D013718:Tensile Strength; D054457:Tissue Scaffolds / Q000737:chemistry*; D014471:Umbilical Veins / Q000187:drug effects / Q000502:physiology / Q000648:ultrastructure
chemical_list: D001672:Biocompatible Materials; D002951:Citrates; D020724:Elastomers; D011108:Polymers; C513817:poly(1,8-octanediol citrate)
keywords: biofunctionalization; citric acid; click chemistry; elastomers; polymers