title: Highly emissive deoxyguanosine analogue capable of direct visualization of B-Z transition.
abstract: A 2-aminothieno[3,4-d]pyrimidine G-mimic deoxyribonucleoside, (th)dG, was synthesized and incorporated readily into oligonucleotides as a versatile fluorescent guanine analogue. We demonstrate that (th)dG enables the visual detection of Z-DNA successfully based on different π-stacking of B- and Z-DNA.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-oiwakecho, Sakyo-ku, Kyoto 606-8502, Japan.
authors.forename: Soyoung
authors.initials: S
authors.lastname: Park
authors.forename: Haruka
authors.initials: H
authors.lastname: Otomo
authors.forename: Linjie
authors.initials: L
authors.lastname: Zheng
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D001483:Base Sequence; D059371:DNA, B-Form / Q000032:analysis*; D043542:DNA, Z-Form / Q000032:analysis*; D003849:Deoxyguanosine / Q000031:analogs & derivatives*; D005456:Fluorescent Dyes / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D059371:DNA, B-Form; D043542:DNA, Z-Form; D005456:Fluorescent Dyes; D009841:Oligonucleotides; D003849:Deoxyguanosine