title: Effectiveness and impact of rotavirus vaccines in the United States - 2006-2012.
abstract: Prior to the introduction of rotavirus vaccines in 2006, rotavirus was the leading cause of severe gastroenteritis among US children <5 years of age. In the first 7 years of vaccine use, both recommended rotavirus vaccines (RotaTeq [RV5] and Rotarix [RV1]) have been shown to be highly effective in preventing outcomes of severe disease in US children in a variety of settings. In addition, substantial decreases in severe diarrheal disease in US children, exceeding the level expected based on vaccine coverage, as well as the extension of benefits to older age groups ineligible for vaccination have demonstrated both the direct and indirect impacts of vaccination in the USA.
authors.affiliation: Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Rha
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Tate
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Payne
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Cortese
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Lopman
authors.forename: Aaron T
authors.initials: AT
authors.lastname: Curns
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
mesh_terms: D002648:Child; D002675:Child, Preschool; D005759:Gastroenteritis / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D007223:Infant; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000276:immunology*; D014481:United States; D014611:Vaccination; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: C492457:RIX4414 vaccine; C492535:RotaTeq; D022243:Rotavirus Vaccines; D014613:Vaccines, Attenuated