title: Emerging roles of the extracellular calcium-sensing receptor in nutrient sensing: control of taste modulation and intestinal hormone secretion.
abstract: The extracellular Ca-sensing receptor (CaSR) is a sensor for a number of key nutrients within the body, including Ca ions (Ca²⁺) and L-amino acids. The CaSR is expressed in a number of specialised cells within the gastrointestinal (GI) tract, and much work has been done to examine CaSR's role as a nutrient sensor in this system. This review article examines two emerging roles for the CaSR within the GI tract--as a mediator of kokumi taste modulation in taste cells and as a regulator of dietary hormone release in response to L-amino acids in the intestine.
authors.forename: Sarah C
authors.initials: SC
authors.lastname: Brennan
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Davies
authors.forename: Martin
authors.initials: M
authors.lastname: Schepelmann
authors.forename: Daniela
authors.initials: D
authors.lastname: Riccardi
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D009752:Nutritional Status; D044169:Receptors, Calcium-Sensing / Q000378:metabolism*; D013649:Taste; D013650:Taste Buds / Q000378:metabolism; D055697:Taste Perception
chemical_list: D000596:Amino Acids; D005768:Gastrointestinal Hormones; D044169:Receptors, Calcium-Sensing; D002118:Calcium