title: Discordant tooth agenesis and peg-shaped in a pair of monozygotic twins: Clinical and molecular study.
abstract: The present report aimed to study an uncommon case of a pair of twins that presented a discordant dental phenotype. Family investigation, clinical, radiographic examination and molecular analysis were performed in both girls. Molecular analysis confirmed the monozygosity by deoxyribonucleic acid chip technology. One twin presented tooth agenesis in left upper lateral incisor and peg-shaped on the contra lateral side while the other twin had no dental alterations. The dental casts study employed digital caliper to compare morphological dimensions and showed alteration only in peg-shaped tooth. In conclusion, this study provide support that one or more mutated gene could cause discordances in dental phenotype in these monozygotic twins.
authors.affiliation: Department of Specific Formation, School of Dentistry, Fluminense Federal University, Nova Friburgo, Brazil.
authors.forename: Lívia Azeredo Alves
authors.initials: LA
authors.lastname: Antunes
authors.affiliation: Unit of Clinical Research, Fluminense Federal University, Niterói, Brazil.
authors.forename: Erika Calvano
authors.initials: EC
authors.lastname: Küchler
authors.affiliation: Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Marcelo de Castro
authors.initials: Mde C
authors.lastname: Costa
authors.affiliation: Department of Specific Formation, School of Dentistry, Fluminense Federal University, Nova Friburgo, Brazil.
authors.forename: Leonardo Santos
authors.initials: LS
authors.lastname: Antunes
authors.affiliation: National Institute of Metrology, Quality and Technology, Head of Bioengineering Program, and Head of Cell Therapy Center, Unit of Clinical Research, Fluminense Federal University, all in Rio de Janeiro, Brazil.
authors.forename: José Mauro
authors.initials: JM
authors.lastname: Granjeiro
keywords: Dental anomalies; dental development; monozygotic twins; tooth agenesis