title: Diabetes: Targeting endoplasmic reticulum to combat juvenile diabetes.
abstract: Limited options for clinical management of patients with juvenile-onset diabetes mellitus call for a novel therapeutic paradigm. Two innovative studies support endoplasmic reticulum as an emerging target for combating both autoimmune and heritable forms of this disease.
authors.affiliation: Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8127, St Louis, MO 63110, USA.
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Urano
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control*; D059865:Endoplasmic Reticulum Stress; D005260:Female; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology*; D050417:Insulin-Secreting Cells / Q000502:physiology*; D007515:Islets of Langerhans / Q000378:metabolism*; D008297:Male; D056811:Unfolded Protein Response; D014929:Wolfram Syndrome / Q000473:pathology*