title: HCV-like IRESs sequester eIF3: advantage virus.
abstract: In a recent Nature paper, Hashem et al. attempted to probe deeper into the elusive role of eIF3 in translation initiation of viruses with hepatitis C virus-like internal ribosome entry sites (IRESs), but instead uncovered a surprising role of these IRESs in displacing eIF3 from the 40S subunit, favoring viral translation.
authors.affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
authors.forename: Debjit
authors.initials: D
authors.lastname: Khan
authors.affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
authors.forename: Prasanna
authors.initials: P
authors.lastname: Bhat
authors.affiliation: Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India. Electronic address: sdas@mcbl.iisc.ernet.in.
authors.forename: Saumitra
authors.initials: S
authors.lastname: Das
mesh_terms: D000818:Animals; D006692:Classical Swine Fever Virus / Q000235:genetics*; D039621:Eukaryotic Initiation Factor-3 / Q000378:metabolism*; D006801:Humans; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism*; D038621:Regulatory Sequences, Ribonucleic Acid / Q000235:genetics*; D054682:Ribosome Subunits, Small, Eukaryotic / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*
chemical_list: D039621:Eukaryotic Initiation Factor-3; D012367:RNA, Viral; D038621:Regulatory Sequences, Ribonucleic Acid