title: [Cu-GnRH--new gonadoliberin (GnRH) analog].
abstract: Our research was concentrated about physiological and structural aspects of metal complexes with GnRH, which were synthetized by Professor Henryk Kozłowski from the Uniwersity of Wrocław. We found that copper, nickel, zinc and cobalt complexes with GnRH stimulated the release of LH and FSH both in vivo and in vitro. The most stable and active was Cu-GnRH. It also exhibited the higher affinity to specific receptor than GnRH, had higher releasing power for LH and FSH and stimulated differently the intracellular signaling. We suggest, that this complex in highly promissive as a new analog of GnRH with possible application to further research.
authors.affiliation: Instytut Fizjologii i Żywienia Zwierząt im. Jana Kielanowskiego Polskiej Akademii Nauk, Zakład Neuroendokrynologii.
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Kochman
mesh_terms: D000818:Animals; D003035:Cobalt / Q000737:chemistry; D003300:Copper; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000737:chemistry*; D006801:Humans; D007986:Luteinizing Hormone / Q000187:drug effects / Q000378:metabolism*; D009532:Nickel / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects*; D015032:Zinc / Q000737:chemistry
chemical_list: D007987:Gonadotropin-Releasing Hormone; D003035:Cobalt; D003300:Copper; D009532:Nickel; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D015032:Zinc