title: Automatic mapping extraction from multiecho T2-star weighted magnetic resonance images for improving morphological evaluations in human brain.
abstract: Mapping extraction is useful in medical image analysis. Similarity coefficient mapping (SCM) replaced signal response to time course in tissue similarity mapping with signal response to TE changes in multiecho T2-star weighted magnetic resonance imaging without contrast agent. Since different tissues are with different sensitivities to reference signals, a new algorithm is proposed by adding a sensitivity index to SCM. It generates two mappings. One measures relative signal strength (SSM) and the other depicts fluctuation magnitude (FMM). Meanwhile, the new method is adaptive to generate a proper reference signal by maximizing the sum of contrast index (CI) from SSM and FMM without manual delineation. Based on four groups of images from multiecho T2-star weighted magnetic resonance imaging, the capacity of SSM and FMM in enhancing image contrast and morphological evaluation is validated. Average contrast improvement index (CII) of SSM is 1.57, 1.38, 1.34, and 1.41. Average CII of FMM is 2.42, 2.30, 2.24, and 2.35. Visual analysis of regions of interest demonstrates that SSM and FMM show better morphological structures than original images, T2-star mapping and SCM. These extracted mappings can be further applied in information fusion, signal investigation, and tissue segmentation.
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, China ; Shenzhen Key Lab for Low-Cost Healthcare, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, China.
authors.forename: Shaode
authors.initials: S
authors.lastname: Yu
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, China ; Shenzhen Key Lab for Low-Cost Healthcare, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, China.
authors.forename: Shibin
authors.initials: S
authors.lastname: Wu
authors.affiliation: Shenzhen Institutes of Advanced Technology, Chinese Academy of Science, China ; Shenzhen Key Lab for Low-Cost Healthcare, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, China.
authors.forename: Yaoqin
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology*; D003287:Contrast Media / Q000737:chemistry; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging; D012016:Reference Values; D012984:Software
chemical_list: D003287:Contrast Media