title: Should dialysate calcium be individualized?
abstract: The growing interest in a personalized choice of dialysate calcium concentration faces some important unsolved questions. First, the desired aims to be achieved should be clarified, as different d-Ca concentrations might differentially impact dialysis calcium balance and serum calcium concentration. A second point to be addressed is how to achieve the desired goals; the kinetics of calcium during dialysis treatment are complex. This is not an easy task and probably only an automatic device able to read serum calcium concentration in real-time and adjust d-Ca to it might supply an effective method for individualizing d-Ca. Finally, it is not even clear whether individualizing d-Ca is worth doing; cost-effectiveness studies might give some further insights into this intricate issue.
authors.affiliation: Nephrology, Dialysis and Renal Transplant Unit, Fondazione Ca' Granda IRCCS, Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Messa
authors.forename: Richard A
authors.initials: RA
authors.lastname: Sherman
mesh_terms: D002118:Calcium / Q000032:analysis*; D015312:Hemodialysis Solutions / Q000737:chemistry*; D006801:Humans; D006934:Hypercalcemia / Q000517:prevention & control; D006996:Hypocalcemia / Q000517:prevention & control; D010281:Parathyroid Hormone / Q000097:blood; D057285:Precision Medicine; D006435:Renal Dialysis
chemical_list: D015312:Hemodialysis Solutions; D010281:Parathyroid Hormone; D002118:Calcium