title: [Synthesis of aminopropylaminoderivatives of betulinic and oleanolic acids].
abstract: On the basis of betulinic and oleanolic acids triterpenoids with different with different amine fragments: (3-aminopropoxy)-, 3-acetyl-(3-aminopropyl)amino-, 6-[bis(3-aminopropyl)amino]hexylamino-, (3-aminopropyl)-4-aminosulfonyl-4-phenylamino- at positions C3 and C28 were synthesized. It is shown that betulonic acid amide with 4,4'-diaminodiphenylsulfonic substituent don't render antitumor effect in mice with transplantable Lewis lung carcinoma, but possess significant anti-inflammatory activity.
authors.forename: G V
authors.initials: GV
authors.lastname: Giniiatullina
authors.forename: O B
authors.initials: OB
authors.lastname: Kazakova
authors.forename: N I
authors.initials: NI
authors.lastname: Medvedeva
authors.forename: I V
authors.initials: IV
authors.lastname: Sorokina
authors.forename: N A
authors.initials: NA
authors.lastname: Zhukova
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000473:pathology; D006632:Histamine / Q000633:toxicity; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D009828:Oleanolic Acid / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D000094062:Betulinic Acid
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C450739:oleanonic acid; D009828:Oleanolic Acid; D006632:Histamine; D000094062:Betulinic Acid