title: Platinum drugs and DNA repair mechanisms in lung cancer.
abstract: The standard first-line treatment for around 80% of newly-diagnosed advanced non-small cell lung cancer (NSCLC) is chemotherapy. Currently, patients are allocated to chemotherapy on the basis of clinical conditions, comorbidities and histology. If feasible, platinum-based chemotherapy is considered as the most efficacious option. Due to the heterogeneity in terms of platinum-sensitivity among patients with NSCLC, great efforts have been made in order to identify molecular predictive markers of platinum resistance. Based on the mechanism of action of platinum, several components of DNA repair pathways have been investigated as potential predictive markers. The main DNA repair pathways involved in the repair of platinum-induced DNA damage are nucleotide excision repair and homologous recombination. The most studied potential predictive markers of platinum-sensitivity are Excision Repair Cross Complementing-1 (ERCC1) and Brest Cancer Type-I Susceptibility protein (BRCA1); however, increasing biological knowledge about DNA repair pathways suggests the potential clinical usefulness of integrated analysis of multiple DNA repair components.
authors.affiliation: Second Medical Oncology Unit, Istituto Oncologico Veneto IRCCS, Via Gattamelata 64, 35128 Padova, Italy. laura.bonanno@ioveneto.it.
authors.forename: Laura
authors.initials: L
authors.lastname: Bonanno
authors.forename: Adolfo
authors.initials: A
authors.lastname: Favaretto
authors.forename: Rafael
authors.initials: R
authors.lastname: Rosell
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D009944:Organoplatinum Compounds / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D045643:DNA Repair Enzymes
keywords: DNA repair mechanisms; Platinum; lung cancer; predictive markers; review