title: Catalytic asymmetric synthesis of 1,3-enyne scaffolds: design and synthesis of conjugated nitro dienynes as novel Michael acceptors and development of a new synthetic methodology.
abstract: A novel catalytic enantioselective synthesis of functionalized 1,3-enynes has been developed featuring the design and synthesis of conjugated nitro dienynes as a useful new class of Michael acceptors. Moreover, a simple, yet flexible catalytic cascade approach to functionalized enantioenriched acyclic α,β-enones and cyclic dienones has also been developed.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. pengfangzhi@ynu.edu.cn zhihui_shao@hotmail.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Fangzhi
authors.initials: F
authors.lastname: Peng
authors.forename: Mingtao
authors.initials: M
authors.lastname: Zhou
authors.forename: Mingjie
authors.initials: M
authors.lastname: Mo
authors.forename: Ruirui
authors.initials: R
authors.lastname: Zhao
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Shao
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D015195:Drug Design; D009574:Nitro Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D009574:Nitro Compounds