title: Investigation of biomarker in laryngeal carcinomas.
abstract: BACKGROUND
  The aim of the study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma.
  
  
  METHODS
  In this study, 33 patients were enrolled and gene expression analysis was performed by qRT-PCR. The podoplanin and GST-T1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryngeal cancer.
  
  
  RESULTS
  Of all included patients, 20 had supraglottic, and 13 had glottic laryngeal cancer. Increased expression of podoplanin was found in seven (35%) supraglottic tumor tissues and seven (53.8%) glottic tumor tissues, but GST-T1 expression was not detected.
  
  
  CONCLUSIONS
  Podoplanin expression did not show any prediction for tumor differentiation, regional metastasis, thyroid cartilage invasion, lymphatic vessel invasion, or tumor differentiation for laryngeal cancer, and also there were no significant differences in podoplanin expression between glottic and supraglottic regions, but extracapsullar extension is almost statistically significance (P = 0.05).
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Kanliada
authors.forename: Ender
authors.initials: E
authors.lastname: Coskunpinar
authors.forename: Kadir Serkan
authors.initials: KS
authors.lastname: Orhan
authors.forename: Yasemin Musteri
authors.initials: YM
authors.lastname: Oltulu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Celik
authors.forename: Ayse
authors.initials: A
authors.lastname: Eren
authors.forename: Ilhan
authors.initials: I
authors.lastname: Yaylim
authors.forename: Kemal
authors.initials: K
authors.lastname: Deger
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005982:Glutathione Transferase / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck; D000098853:Podoplanin
chemical_list: D015415:Biomarkers; D005982:Glutathione Transferase; D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin; C413545:glutathione S-transferase T1
keywords: GST-T1; Podoplanin; biomarker; laryngeal carcinoma; squamous cell carcinoma