title: Detection of lung cancer by FDG-PET cancer screening program: a nationwide Japanese survey.
abstract: OBJECTIVE
  The aim of this study was to analyze the lung cancer detection rate in asymptomatic individuals by the Fluorine-18 fluorodeoxyglucose-positron emission tomography FDG-PET cancer screening program in Japan.
  
  
  METHODS
  A total of 153,775 asymptomatic individuals underwent the FDG-PET cancer screening program; the 854 cases with findings that indicated suspected lung cancer by any detection method were analyzed.
  
  
  RESULTS
  Among the 854 cases, 319 were verified as lung cancer. The relative sensitivity and positive predictive value (PPV) of FDG-PET were 86.5% and 38.9% for lung cancer, respectively. The sensitivity of PET/computed tomography (CT) scanner was higher than that of dedicated PET (100.0% vs. 63.2%), indicating that CT imaging was effective for lung cancer screening. The majority of lung carcinomas detected by FDG-PET screening were UICC stage IA or IB, but detection of smaller or less invasive carcinomas was limited.
  
  
  CONCLUSIONS
  The FDG-PET screening program in Japan detected lung cancer at an early stage.
authors.affiliation: Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, 1-21-1, Toyama, Shinjyuku-ku, Tokyo, 162-8655, Japan. ryogominamimoto@yahoo.co.jp.
authors.forename: Ryogo
authors.initials: R
authors.lastname: Minamimoto
authors.forename: Michio
authors.initials: M
authors.lastname: Senda
authors.forename: Seishi
authors.initials: S
authors.lastname: Jinnouchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Terauchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Kimiichi
authors.initials: K
authors.lastname: Uno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Iinuma
authors.forename: Takeshi
authors.initials: T
authors.lastname: Murano
authors.forename: Rumi
authors.initials: R
authors.lastname: Nakashima
authors.forename: Tomio
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D055088:Early Detection of Cancer; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006306:Health Surveys; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009313:National Health Programs; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: FDG; Japan; PET; PET/CT; cancer screening; lung cancer