title: Complex single-chain polymer topologies locked by positionable twin disulfide cyclic bridges.
abstract: Oligomers containing the peptide sequence cysteine-any-cysteine (CXC) were attached, at specific locations, to a linear chain of polystyrene. The polymer-bound peptide motifs were then oxidized under dilute conditions to afford a complex bio-hybrid bi-cyclic topology via intramolecular twin disulfide bridge formation.
authors.affiliation: Precision Macromolecular Chemistry Group, Institut Charles Sadron, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2, France. jflutz@unistra.fr.
authors.forename: Olga
authors.initials: O
authors.lastname: Shishkan
authors.forename: Mirela
authors.initials: M
authors.lastname: Zamfir
authors.forename: Marc Andre
authors.initials: MA
authors.lastname: Gauthier
authors.forename: Hans G
authors.initials: HG
authors.lastname: Börner
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Lutz
mesh_terms: D003500:Cyclization; D003545:Cysteine / Q000737:chemistry*; D004220:Disulfides / Q000737:chemistry; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*
chemical_list: D004220:Disulfides; D010455:Peptides; D011137:Polystyrenes; D003545:Cysteine