title: Treating HCV in HIV 2013: on the cusp of change.
abstract: Treating hepatitis C virus (HCV) in HIV/HCV co-infected patients is a challenge. Even if the benefits of achieving a sustained virological response are clear, the rates achieved with the combination of pegylated-interferon and ribavirin are disappointing. The addition of direct acting antiviral agents (DAAs) to the treatment of hepatitis C is revolutionizing the treatment of HCV in mono-infected patients. Even if there have not been any agents approved for the treatment of co-infected patients, many studies specifically designed for this population are ongoing. This article reviews available data on the use of DAAs in co-infected patients and the challenges associated with these new drugs.
authors.affiliation: Département de Microbiologie et Infectiologie, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada.
authors.forename: Valérie
authors.initials: V
authors.lastname: Martel-Laferrière
authors.forename: Douglas T
authors.initials: DT
authors.lastname: Dieterich
mesh_terms: D000621:Aminoisobutyric Acids; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002219:Carbamates; D060085:Coinfection / Q000188:drug therapy*; D004347:Drug Interactions / Q000502:physiology; D004359:Drug Therapy, Combination / Q000379:methods* / Q000639:trends; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles; D007930:Leucine / Q000031:analogs & derivatives; D009842:Oligopeptides; D011392:Proline / Q000031:analogs & derivatives; D011759:Pyrrolidines; D011804:Quinolines; D000069474:Sofosbuvir; D013844:Thiazoles; D016896:Treatment Outcome; D014542:Uridine Monophosphate / Q000031:analogs & derivatives; D014633:Valine / Q000031:analogs & derivatives
chemical_list: D000621:Aminoisobutyric Acids; D000998:Antiviral Agents; D002219:Carbamates; D007093:Imidazoles; D009842:Oligopeptides; D011759:Pyrrolidines; D011804:Quinolines; D013844:Thiazoles; C486464:telaprevir; C512204:N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide; C552340:faldaprevir; D011392:Proline; D014542:Uridine Monophosphate; D007930:Leucine; D014633:Valine; C549273:daclatasvir; D000069474:Sofosbuvir
keywords: HIV; co-infection; direct acting antiviral agents; hepatitis C