title: Retention studies of recoiling daughter nuclides of 225Ac in polymer vesicles.
abstract: Alpha radionuclide therapy is steadily gaining importance and a large number of pre-clinical and clinical studies have been carried out. However, due to the recoil effects the daughter recoil atoms, most of which are alpha emitters as well, receive energies that are much higher than the energies of chemical bonds resulting in decoupling of the radionuclide from common targeting agents. Here, we demonstrate that polymer vesicles (i.e. polymersomes) can retain recoiling daughter nuclei based on an experimental study examining the retention of (221)Fr and (213)Bi when encapsulating (225)Ac.
authors.affiliation: Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Wang
authors.affiliation: Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.
authors.forename: R M
authors.initials: RM
authors.lastname: de Kruijff
authors.affiliation: Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.
authors.forename: A
authors.initials: A
authors.lastname: Rol
authors.affiliation: Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Thijssen
authors.affiliation: Department of Chemical Engineering, Delft University of Technology, Julianalaan 136, 2628 BL Delft, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Mendes
authors.affiliation: European Commission, Joint Research Centre, Institute for Transuranium Elements, PO Box 2340, 76125 Karlsruhe, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Morgenstern
authors.affiliation: European Commission, Joint Research Centre, Institute for Transuranium Elements, PO Box 2340, 76125 Karlsruhe, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Bruchertseifer
authors.affiliation: Electron Microscopy Group, Groningen, Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborgh 7, 9747 AG Groningen, The Netherlands.
authors.forename: M C A
authors.initials: MC
authors.lastname: Stuart
authors.affiliation: Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands.
authors.forename: H T
authors.initials: HT
authors.lastname: Wolterbeek
authors.affiliation: Radiation Science and Technology, Delft University of Technology, Mekelweg 15, 2629 JB Delft, The Netherlands. Electronic address: a.g.denkova@tudelft.nl.
authors.forename: A G
authors.initials: AG
authors.lastname: Denkova
mesh_terms: D000186:Actinium / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D000512:Alpha Particles / Q000627:therapeutic use; D001693:Biological Transport, Active; D001729:Bismuth / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D002070:Butadienes / Q000737:chemistry; D004339:Drug Compounding; D005605:Francium / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D007856:Lead Radioisotopes / Q000737:chemistry; D009010:Monte Carlo Method; D010316:Particle Size; D020959:Polyethylene / Q000737:chemistry; D011868:Radioisotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D002070:Butadienes; D007856:Lead Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C473741:poly(1,2-butadiene-b-ethylene oxide); D005605:Francium; D020959:Polyethylene; D000186:Actinium; D001729:Bismuth
keywords: Alpha radionuclide therapy; Polymersomes; Recoil retention