title: Systematic review of 2008-2012 literature and update of recommendations for the use of methotrexate in rheumatic diseases, with a focus on rheumatoid arthritis.
abstract: The objective of this review is to update the recommendations of the 2010 Italian Consensus on the use of methotrexate (MTX) in rheumatoid arthritis (RA) and other rheumatic diseases. The literature published between 2008 and 2012 was systematically reviewed and updated recommendations on MTX use in rheumatic diseases, particularly RA, were formulated. These recommendations were approved by a panel of expert Italian Rheumatologists. A total of 10,238 references were identified, among which 70 studies were selected for critical evaluation. Sufficient evidence had accumulated to warrant changes to several of the recommendations in the new version. A new recommendation for patients with RA who are in MTX-induced clinical remission was also proposed and approved by the panel. Updated recommendations for the use of MTX in patients with RA or other rheumatologic disease are proposed.
authors.affiliation: Rheumatology, IRCCS S. Matteo, University of Pavia. katodina@libero.it.
authors.forename: M
authors.initials: M
authors.lastname: Todoerti
authors.forename: W
authors.initials: W
authors.lastname: Maglione
authors.forename: E
authors.initials: E
authors.lastname: Bernero
authors.forename: A
authors.initials: A
authors.lastname: Bortoluzzi
authors.forename: M
authors.initials: M
authors.lastname: Colaci
authors.forename: E
authors.initials: E
authors.lastname: Galuppi
authors.forename: S
authors.initials: S
authors.lastname: Paolino
authors.forename: R
authors.initials: R
authors.lastname: Talarico
authors.forename: M
authors.initials: M
authors.lastname: Cutolo
authors.forename: C
authors.initials: C
authors.lastname: Ferri
authors.forename: F
authors.initials: F
authors.lastname: Trotta
authors.forename: S
authors.initials: S
authors.lastname: Bombardieri
authors.forename: C Maurizio
authors.initials: CM
authors.lastname: Montecucco
authors.forename: L
authors.initials: L
authors.lastname: Sinigaglia
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate