title: Transfusion--whence and why.
abstract: The past is prologue. Reviewing the history of transfusion tells us how far we have come, but also where we need to go. The past has been filled with innovation and important discoveries, but is also fraught with stumbling blocks and unintended side effects. Although much has been achieved and transfusion is safer today than ever, nonetheless we are recognizing new potential concerns with transfusion and we are undergoing a paradigm shift in our attitudes, approach and patient management in regard to blood transfusion.
authors.affiliation: St Michael's Hospital, Medicine & Laboratory Medicine & Pathobiology, University of Toronto, St Michael's Hospital, 30 Bond Street, Room 2-006, Shuter Wing, Toronto, ON M5B 1W8, Canada. Electronic address: freedman@smh.ca.
authors.forename: John
authors.initials: J
authors.lastname: Freedman
mesh_terms: D001771:Blood Banks; D001782:Blood Donors; D001793:Blood Preservation / Q000379:methods; D001800:Blood Specimen Collection / Q000379:methods; D001803:Blood Transfusion / Q000266:history* / Q000379:methods*; D001804:Blood Transfusion, Autologous; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans
keywords: Blood conservation; Blood transfusion; History; Paradigm shift; Patient blood management