title: Significant roles played by IL-10 in Chlamydia infections.
abstract: Chlamydia species are obligate intracellular parasites which cause usually asymptomatic genital tract infections and also are associated with several complications. Previous studies demonstrated that immune responses to Chlamydia species are different and the diseases will be limited to some cases. Additionally, Chlamydia species are able to modulate immune responses via regulating expression of some immune system molecules including cytokines. IL-10, as the main anti-inflammatory cytokine, plays important roles in the induction of immune-tolerance against self-antigen and also immune-homeostasis after microbe elimination. Furthermore, it has been documented that ectopic expression of IL-10 is associated with several chronic infectious diseases. Therefore, it can be hypothesized that changes in the regulation of this cytokine can be associated with infection with several species of Chlamydia and their associated complications. This review collected the recent information regarding the association and relationship of IL-10 with Chlamydia infections. Another aim of this review article is to address recent data regarding the association of genetic variations (polymorphisms) of IL-10 and Chlamydia infections.
authors.affiliation: Immunology of Infectious Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Hakimi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zare-Bidaki
authors.forename: Nahid
authors.initials: N
authors.lastname: Zainodini
authors.forename: Shokrollah
authors.initials: S
authors.lastname: Assar
authors.forename: Mohammad Kazemi
authors.initials: MK
authors.lastname: Arababadi
mesh_terms: D002689:Chlamydia / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000382:microbiology; D016753:Interleukin-10 / Q000096:biosynthesis / Q000235:genetics* / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide; D060737:Reproductive Tract Infections / Q000276:immunology / Q000382:microbiology
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10