title: Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251.
abstract: The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A-C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.
authors.affiliation: Chemical Synthesis Laboratory, SB-ISIC-LSYNC, Swiss Federal Institute of Technology (EPFL) , CH-1015 Lausanne, Switzerland.
authors.forename: Cyril
authors.initials: C
authors.lastname: Portmann
authors.forename: Simon
authors.initials: S
authors.lastname: Sieber
authors.forename: Silvan
authors.initials: S
authors.lastname: Wirthensohn
authors.forename: Judith F
authors.initials: JF
authors.lastname: Blom
authors.forename: Laeticia
authors.initials: L
authors.lastname: Da Silva
authors.forename: Emilie
authors.initials: E
authors.lastname: Baudat
authors.forename: Marcel
authors.initials: M
authors.lastname: Kaiser
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Karl
authors.initials: K
authors.lastname: Gademann
mesh_terms: D000818:Animals; D046931:Microcystis / Q000737:chemistry*; D032446:Myoblasts / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D010963:Plasmodium falciparum / Q000187:drug effects*; D051381:Rats; D016833:Trypanosoma brucei rhodesiense / Q000187:drug effects
chemical_list: D010456:Peptides, Cyclic; C000589277:balgacyclamide A; C000589278:balgacyclamide B; C000589279:balgacyclamide C