title: Synthesis of novel and diverse mollugin analogues and their antibacterial and antioxidant activities.
abstract: Novel and diverse mollugin analogues (1-12) were synthesized using PhB(OH)2/AcOH-mediated electrocyclization reaction as a key step. The newly synthesized compounds were screened for antioxidant and antibacterial activities. Compounds 1, 2, 5, 6, 8, and 10-12 showed high antioxidant activities in DPPH inhibition (IC50=0.52-1.11 μM) compared with BHT (IC50=9.67 μM). Compounds 3 exhibited potent antibacterial activity against Staphylococcus aureus (KCTC-1916) bacterial strain at 100 μg/mL. Structures of newly synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR data and high-resolution mass spectrometry.
authors.affiliation: School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
authors.forename: Akber
authors.initials: A
authors.lastname: Idhayadhulla
authors.affiliation: School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
authors.forename: Likai
authors.initials: L
authors.lastname: Xia
authors.affiliation: School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea. Electronic address: yrlee@yu.ac.kr.
authors.forename: Yong Rok
authors.initials: YR
authors.lastname: Lee
authors.affiliation: Analysis Research Division, Daegu Center, Korea Basic Science Institute, Daegu 702-701, Republic of Korea.
authors.forename: Sung Hong
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Food Science and Technology, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
authors.forename: Young-Jung
authors.initials: YJ
authors.lastname: Wee
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan 712-749, Republic of Korea.
authors.forename: Chong-Soon
authors.initials: CS
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D011714:Pyrans; C046245:rubimaillin
keywords: 3,4-Dihydromollugin; Antibacterial activity; Antioxidant activity; Mollugin