title: miR-92a family and their target genes in tumorigenesis and metastasis.
abstract: The miR-92a family, including miR-25, miR-92a-1, miR-92a-2 and miR-363, arises from three different paralog clusters miR-17-92, miR-106a-363, and miR-106b-25 that are highly conservative in the process of evolution, and it was thought as a group of microRNAs (miRNAs) correlated with endothelial cells. Aberrant expression of miR-92a family was detected in multiple cancers, and the disturbance of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress on the relationship between miR-92a family and their target genes and malignant tumors will be summarized.
authors.affiliation: Department of Pathophysiology, Basic Medical Science of Dalian Medical University, Dalian 116044, China; Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian 116044, China. Electronic address: molin_li@hotmail.com.
authors.forename: Molin
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Pathophysiology, Basic Medical Science of Dalian Medical University, Dalian 116044, China.
authors.forename: Xingfang
authors.initials: X
authors.lastname: Guan
authors.affiliation: Department of Pathophysiology, Basic Medical Science of Dalian Medical University, Dalian 116044, China.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian 116044, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Mi
authors.affiliation: College of Pharmacy, Dalian Medical University Cancer Center, Dalian 116044, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Shu
authors.affiliation: Department of Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China. Electronic address: li_chuangang@sina.com.
authors.forename: Chuangang
authors.initials: C
authors.lastname: Li
mesh_terms: D017209:Apoptosis / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D042783:Endothelial Cells / Q000166:cytology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009362:Neoplasm Metastasis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*
chemical_list: C541874:MIRN92 microRNA, human; D035683:MicroRNAs
keywords: Regulation; Target genes; Tumors; miR-92a family