title: Endothelial protein C receptor and pediatric arterial stroke.
abstract: OBJECTIVE
  The aim of this study was to investigate the endothelial protein C receptor (EPCR) gene A3 haplotype and plasma soluble EPCR (sEPCR) levels in Turkish pediatric arterial stroke patients.
  
  
  METHODS
  We analyzed 44 pediatric arterial stroke patients and 75 healthy controls. Following DNA isolation, genotyping of the A3 haplotype was determined via PCR and RFLP. Additionally, fasting sEPCR levels were determined via ELISA.
  
  
  RESULTS
  There wasn't a significant difference in the sEPCR level between the control and patient groups, although the sEPCR level was higher in the patient group. We didn't observe a difference in the distribution of the CC and CG/GG genotypes between the control and patient groups.
  
  
  CONCLUSIONS
  Further study on sEPCR levels at the onset of pediatric stroke is needed in order to reach a more definitive conclusion.
  
  
  BACKGROUND
  None declared.
authors.affiliation: Ankara University, School of Medicine, Department of Pediatric Molecular Genetics, Ankara, Turkey.
authors.forename: Nejat
authors.initials: N
authors.lastname: Akar
authors.affiliation: Ankara University, School of Medicine, Department of Pediatric Molecular Genetics, Ankara, Turkey.
authors.forename: Afife
authors.initials: A
authors.lastname: Karabıyık
authors.affiliation: Ankara University, School of Medicine, Department of Pediatric Neurology, Ankara, Turkey.
authors.forename: Gülhis
authors.initials: G
authors.lastname: Deda
keywords: A3; EPCR; Pediatric stroke; sEPCR