title: High-density lipoprotein: vascular protective effects, dysfunction, and potential as therapeutic target.
abstract: High-density lipoprotein (HDL) is a complex mixture of lipoproteins that is associated with many minor proteins and lipids that influence the function of HDL. Although HDL is a promising marker and potential therapeutic target based on its epidemiological data and the effects of healthy HDL in vitro in endothelial cells and macrophages, as well as based on infusion studies of reconstituted HDL in patients with hypercholesterolemia, it remains still uncertain whether or not HDL cholesterol-raising drugs will improve outcomes. Recent studies suggest that HDL becomes modified in patients with coronary artery disease or acute coronary syndrome because of oxidative processes that result in alterations in its proteome composition (proteome remodelling) leading to HDL dysfunction.
authors.affiliation: From Department of Cardiology, University Heart Center (T.F.L., U.L.), and Department of Clinical Chemistry (A.v.E.), University Hospital Zurich, Zurich, Switzerland; Division of Cardiovascular Research, Institute of Physiology, University of Zurich, Zurich, Switzerland (T.F.L., U.L.); and Department of Medicine, University of California, Los Angeles, CA (A.M.F.).
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Lüscher
authors.forename: Ulf
authors.initials: U
authors.lastname: Landmesser
authors.forename: Arnold
authors.initials: A
authors.lastname: von Eckardstein
authors.forename: Alan M
authors.initials: AM
authors.lastname: Fogelman
mesh_terms: D054058:Acute Coronary Syndrome / Q000378:metabolism / Q000517:prevention & control; D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D053480:Cholesterol Ester Transfer Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
chemical_list: D000924:Anticholesteremic Agents; D053480:Cholesterol Ester Transfer Proteins; D008075:Lipoproteins, HDL
keywords: apolipoprotein A-I; cholesterol, HDL; nitric oxide