title: 4-Quinolone alkaloids from Melochia odorata.
abstract: The methanol extract of Melochia odorata yielded three 4-quinolone alkaloids including waltherione A (1) and two new alkaloids, waltherione C (2) and waltherione D (3). Waltheriones A and C showed significant activities in an in vitro anti-HIV cytoprotection assay at concentrations of 56.2 and 0.84 μM and inhibition of HIV P24 formation of more than 50% at 1.7 and 0.95 μM, respectively. The structures of the alkaloids were established by spectroscopic data interpretation.
authors.affiliation: Department of Pharmacology and Toxicology, University of Utah , Salt Lake City, Utah, United States.
authors.forename: Raquel C
authors.initials: RC
authors.lastname: Jadulco
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Pond
authors.forename: Ryan M
authors.initials: RM
authors.lastname: Van Wagoner
authors.forename: Michael
authors.initials: M
authors.lastname: Koch
authors.forename: Osia G
authors.initials: OG
authors.lastname: Gideon
authors.forename: Teatulohi K
authors.initials: TK
authors.lastname: Matainaho
authors.forename: Pius
authors.initials: P
authors.lastname: Piskaut
authors.forename: Louis R
authors.initials: LR
authors.lastname: Barrows
mesh_terms: D042462:4-Quinolones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016655:HIV Core Protein p24 / Q000037:antagonists & inhibitors; D019660:Malvaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010219:Papua New Guinea; D018547:Plant Stems / Q000737:chemistry; D011804:Quinolines
chemical_list: D042462:4-Quinolones; D000470:Alkaloids; D019380:Anti-HIV Agents; D016655:HIV Core Protein p24; D011804:Quinolines; C587675:waltherione C; C502881:waltherione-A