title: The hyaline vascular type of Castleman's disease of the ovary: a case report.
abstract: Castleman's disease in the pelvic cavity is rare. We present a 72-year-old woman with hyaline vascular type of Castleman's disease of the right ovary. Right ovarian enlargement was detected in the medical examination. Computed tomography revealed a solid mass, measured 2.5 cm in size, in the right ovary. A bilateral salpingo-oophorectomy was performed. Morphologically, lymphoid follicles with regressed germinal centers (GCs) were surrounded by a broad mantle zone composed of concentric rings of small lymphocytes, and the hyalinized blood vessels with plump endothelial cells penetrated radially into GCs. Proliferation of follicular dendritic cells, which were positive for CD21 and epidermal growth factor receptor, were detected in GCs and mantle zone. No other lesions were found. To the best of our knowledge, this is the first case of hyaline vascular type of Castleman's disease of ovarian primary.
authors.affiliation: Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Hatanaka
authors.affiliation: Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Yoshioka
authors.affiliation: Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tasaki
authors.affiliation: Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan akit09@m3.kufm.kagoshima-u.ac.jp.
authors.forename: Akihide
authors.initials: A
authors.lastname: Tanimoto
mesh_terms: D000368:Aged; D005871:Castleman Disease / Q000473:pathology*; D005260:Female; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D010049:Ovarian Diseases / Q000473:pathology*
keywords: Castleman’s disease; hyaline vascular type; ovary