title: Exploring the activated adipogenic niche: interactions of macrophages and adipocyte progenitors.
abstract: Adult adipose tissue contains a large supply of progenitors that can renew fat cells for homeostatic tissue maintenance and adaptive growth or regeneration in response to external challenges. However, the in vivo mechanisms that control adipocyte progenitor behavior are poorly characterized. We recently demonstrated that recruitment of adipocyte progenitors by macrophages is a central feature of adipose tissue remodeling under various adipogenic conditions. Catabolic remodeling of white adipose tissue by β3-adrenergic receptor stimulation requires anti-inflammatory M2-polarized macrophages to clear dying adipocytes and to recruit new brown adipocytes from progenitors. In this Extra Views article, we discuss in greater detail the cellular elements of adipogenic niches and report a strategy to isolate and characterize the subpopulations of macrophages and adipocyte progenitors that actively participate in adrenergic tissue remodeling. Further characterization of these subpopulations may facilitate identification of new cellular targets to improve metabolic and immune function of adipose tissue.
authors.affiliation: Center for Integrative and Metabolic Endocrine Research; Wayne State University School of Medicine; Detroit, MI USA.
authors.forename: Yun-Hee
authors.initials: YH
authors.lastname: Lee
authors.affiliation: EMD Millipore; Seattle, WA USA.
authors.forename: Robert I
authors.initials: RI
authors.lastname: Thacker
authors.affiliation: EMD Millipore; Seattle, WA USA.
authors.forename: Brian Eric
authors.initials: BE
authors.lastname: Hall
authors.affiliation: EMD Millipore; Seattle, WA USA.
authors.forename: Raymond
authors.initials: R
authors.lastname: Kong
authors.affiliation: Center for Integrative and Metabolic Endocrine Research; Wayne State University School of Medicine; Detroit, MI USA.
authors.forename: James G
authors.initials: JG
authors.lastname: Granneman
mesh_terms: D052437:Adipocytes, Brown / Q000166:cytology / Q000502:physiology; D052438:Adipocytes, White / Q000166:cytology / Q000502:physiology*; D050156:Adipogenesis; D000818:Animals; D018960:Hyaluronan Receptors / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism; D022702:Receptors, Adrenergic, beta-3 / Q000378:metabolism; D055153:Stem Cell Niche / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
chemical_list: C568534:ADRB3 protein, human; D018960:Hyaluronan Receptors; D022702:Receptors, Adrenergic, beta-3; D020796:Receptor, Platelet-Derived Growth Factor alpha
keywords: adipocyte progenitors; adipogenesis; adipose tissue remodeling; macrophages; proliferation