title: The role of LAIR-1 (CD305) in T cells and monocytes/macrophages in patients with rheumatoid arthritis.
abstract: The LAIR-1 receptor is expressed on a majority of mononuclear leukocytes. It is used as a biomarker when testing synovial fluid for evidence of rheumatoid arthritis (RA). The primary objective of this study was to measure T cell- and monocyte/macrophage-specific LAIR-1 expression in RA patients and compare this to LAIR-1 expression in osteoarthritis (OA) patients and healthy individuals. LAIR-1 expression was significantly decreased in circulating CD4(+) T cells in RA patients compared to both OA patients and healthy individuals. In contrast, LAIR-1 is high in CD14(+) monocytes and local CD68(+) macrophages in synovial tissues from RA patients. Upon stimulation with TNF-α, LAIR-1 expression decreased in T-helper (Th)1 and Th2 CD4(+) T cells from healthy donors. These results indicate that LAIR-1 may exert different functions on T cells and monocytes/macrophages and suggest that LAIR-1 may be a novel therapeutic target for the treatment of RA.
authors.affiliation: Department of Physiology, Fourth Military Medical University, #17 Changle West Road, Xi'an 710032, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Orthopedic, The Second Affiliated Hospital, Xi'an Jiaotong University College of Medicine, #157 Xiwu Road, Xi'an 710003, China.
authors.forename: K
authors.initials: K
authors.lastname: Lv
authors.affiliation: Department of Immunology, Fourth Military Medical University, #17 Changle West Road, Xi'an 710032, China.
authors.forename: C M
authors.initials: CM
authors.lastname: Zhang
authors.affiliation: Department of Immunology, Fourth Military Medical University, #17 Changle West Road, Xi'an 710032, China.
authors.forename: B Q
authors.initials: BQ
authors.lastname: Jin
authors.affiliation: Department of Immunology, Fourth Military Medical University, #17 Changle West Road, Xi'an 710032, China. Electronic address: fmmuzhr@fmmu.edu.cn.
authors.forename: R
authors.initials: R
authors.lastname: Zhuang
authors.affiliation: Department of Orthopedic, Tangdu Hospital, Fourth Military Medical University, #1 Xinsi Road, Xi'an 710038, China. Electronic address: zhangyuan@fmmu.edu.cn.
authors.forename: Y
authors.initials: Y
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015415:Biomarkers / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D010003:Osteoarthritis / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology / Q000378:metabolism*; D013583:Synovial Membrane / Q000276:immunology; D058408:Th1-Th2 Balance
chemical_list: D015415:Biomarkers; D011971:Receptors, Immunologic; C108073:leukocyte-associated immunoglobulin-like receptor 1
keywords: LAIR-1; Monocytes/macrophages; Rheumatoid arthritis; T cells