title: [The efficacy of neoadjuvant chemotherapy with S-1/CDDP (SP) to the patients with large type 3 and type 4 gastric cancer].
abstract: Here, I examined the efficacy of neoadjuvant chemotherapy( NAC) with S-1/CDDP( SP) in my hospital. The subjects were 8 patients with advanced gastric cancer who had undergone NAC since 2007 (7 men and 1 woman; median age, 70 years). The staging before the treatment was Stage II A: 1 patient, II B: 2 patients, III B: 3 patients, III C: 1 patient, and IV: 1 patient. The macroscopic type of 3 and 5 patients was large type 3 and type 4, respectively. Gastrectomy was performed following the NAC with SP. The NAC response rate was 62.5%. In the histological response criteria, 1 patient was grade 0, 2 patients were grade 1a, 2 patients were grade 1b, and 3 patients were grade 2. Adverse events following the NAC were in the acceptable range. We noted that the presence of Stage IV or grade 0 histological response criteria to NAC indicated poor prognosis. Thus, I believe that preoperative surgery after NAC in Stage III gastric cancer should be considered to be curative.
authors.affiliation: Dept. of Surgery, Tokyo Medical University Hachioji Medical Center.
authors.forename: Soh
authors.initials: S
authors.lastname: Katayanagi
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Nomura
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Sumi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Suda
authors.forename: Sumito
authors.initials: S
authors.lastname: Hoshino
authors.forename: Kazushige
authors.initials: K
authors.lastname: Ito
authors.forename: Yu
authors.initials: Y
authors.lastname: Takagi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tsuchida
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Kawachi
authors.forename: Motohide
authors.initials: M
authors.lastname: Shimazu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects; D004338:Drug Combinations; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin