title: [Multivariate analysis of prognostic factors in the eldly patients with small cell lung cancer: a study of 160 patients].
abstract: OBJECTIVE
  Lung cancer is currently the leading cause of cancer death, two thirds of patients are over the age of 65. Small cell lung cancer (SCLC) accounts for about 15%-20% of all lung cancer. The objective of this study is to evaluate the survival of patients older than 65 with SCLC and analyze the independent prognostic factors in this group of patients.
  
  
  METHODS
  A retrospective study has enrolled 160 cases of lung cancer aged over 65. The prognostic factors were analyzed by Kaplan-Meier and Cox multivariate proportional hazards model.
  
  
  RESULTS
  ① The median follow-up time was 12 (2-109) months. 1-, 3-, and 5-year survival rate was 47.1%, 13.0%, 9.6% respectively, and 74.4%, 25.0%, 19.7% for limited-stage (LD), and 36.8%, 8.7%, 5.8% for extensive-stage (ED). Median survival time (MST) of all the patients was 12 months, 24 months for LD and 11 months for ED, respectively. ② Multivariate analysis suggested that performance status (PS) pre-treatment, the change of PS after treatment, stage, liver metastases and thoracic radiotherapy were the independent prognostic factors in all patients. ③ For LD-SCLC patients, PS pre-treatment, thoracic radiotherapy were the independent prognostic factors. The model of thoracic radiotherapy (concurrent chemoradiation vs sequential chemoradiation, early concurrent chemoradiation vs late concurrent chemoradiation) and prophylactic cranial irradiation (PCI) did not show significant difference. ④ For ED-SCLC patients, sex, the change of PS after treatment, chemotherapy, liver metastases, thoracic radiotherapy, PCI were the independent prognostic factors.
  
  
  CONCLUSIONS
  The survival time is related to PS and thoracic radiotherapy in eldly patients. Besides, it is also related to sex, chemotherapy, liver metastases and PCI for ED-SCLC.
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Chen
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Fang
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Nie
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Dai
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Weiheng
authors.initials: W
authors.lastname: Hu
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Jindi
authors.initials: J
authors.lastname: Han
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Xiangjuan
authors.initials: X
authors.lastname: Ma
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Guangming
authors.initials: G
authors.lastname: Tian
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Han
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Jieran
authors.initials: J
authors.lastname: Long
authors.affiliation: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), the Second Department of Chest Cancer, Peking University Cancer Hospital and Institute, Beijing 100142, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis* / Q000473:pathology; D016019:Survival Analysis