title: Characteristics and natural history of patients with colorectal cancer complicated by infectious endocarditis. Case control study of 25 patients.
abstract: Association between streptococcal endocarditis and gastrointestinal disease has been well-documented in the literature. However oncological impact of this complicated presentation has not yet been reported. We have conducted to our knowledgethe first case-control study on this subject.
  
  
  METHODS
  Two groups of five patients with colorectal cancer and either active endocarditis (CRC E+), or without endocarditis (CRC, n=20) were matched 1:4 for age, sex, and location of colorectal tumor.
  
  
  RESULTS
  All 25 patients were male, with a median age of 63 (range: 53-85) years. Twenty (80%) had colon cancer and 5 (20%) rectal cancer. There was no post-operative mortality in this population. The overall morbidity was 28% (n=7). The overall 3-year survival and recurrence rates were similar in both groups 80% and 95%; 0% and 30% for group CRC E+ and CRC (p=0.4603).
  
  
  CONCLUSIONS
  This is the first case-control study demonstrating that during the first two years of follow-up, occurrence of endocarditis did not alter the prognosis of patients with CRC.
authors.affiliation: Service de Chirurgie Digestive et viscérale, Pôle DACCORD, Hopital Timone .264 rue saint Pierre, 13385 Marseille, France. mehdi.ouaissi@mail.ap-hm.fr.
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ouaïssi
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Studer
authors.forename: Diane
authors.initials: D
authors.lastname: Mege
authors.forename: Franck
authors.initials: F
authors.lastname: Thuny
authors.forename: Laurence
authors.initials: L
authors.lastname: Boiron
authors.forename: Anderson
authors.initials: A
authors.lastname: Loundou
authors.forename: Nicolas
authors.initials: N
authors.lastname: Pirrò
authors.forename: Samy
authors.initials: S
authors.lastname: Hamed
authors.forename: Cecilia
authors.initials: C
authors.lastname: Frasconi
authors.forename: Gilbert
authors.initials: G
authors.lastname: Habib
authors.forename: Pierre-Edouard
authors.initials: PE
authors.lastname: Fournier
authors.forename: Fréderic
authors.initials: F
authors.lastname: Collart
authors.forename: Igor
authors.initials: I
authors.lastname: Sielezneff
authors.forename: Bernard
authors.initials: B
authors.lastname: Sastre
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000209:etiology / Q000401:mortality* / Q000601:surgery; D017548:Echocardiography, Transesophageal; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D013290:Streptococcal Infections / Q000150:complications* / Q000382:microbiology; D013291:Streptococcus / Q000302:isolation & purification*; D015996:Survival Rate
keywords: Colorectal cancer; Streptococcus gallolyticus; endocarditis