title: Pharmacokinetic delivery and metabolizing rate of nicardipine incorporated in hydrophilic and hydrophobic cyclodextrins using two-compartment mathematical model.
abstract: The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-β-cyclodextrin (NC/HPβCD) and hydrophobic triacetyl-β-cyclodextrin (NC/TAβCD), through the body for controlled drug delivery and sustained release have been examined. The two-compartment pharmacokinetic model described the mechanisms of how the human body handles with ingestion of NC-cyclodextrin complexes in gastrointestinal tract (GI), distribution in plasma, and their metabolism in the liver. The model showed that drug bioavailability was significantly improved after oral administration of cyclodextrin complexes. The mathematical significance of this study to predict nicardipine delivery using pharmacokinetic two-compartment mathematical model with linear ordinary differential equations (ODE) approach represents a valuable tool to emphasize its effectiveness and metabolizing rate and diminish the side effects.
authors.affiliation: Department of Anaesthesia and Critical Care, University of Würzburg, 97080 Würzburg, Germany.
authors.forename: Sergey
authors.initials: S
authors.lastname: Shityakov
authors.affiliation: Department of Anaesthesia and Critical Care, University of Würzburg, 97080 Würzburg, Germany.
authors.forename: Carola
authors.initials: C
authors.lastname: Förster
mesh_terms: D000284:Administration, Oral; D000465:Algorithms; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002853:Chromatography, Liquid; D003198:Computer Simulation; D003505:Cyclodextrins / Q000097:blood / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D041981:Gastrointestinal Tract / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008962:Models, Theoretical; D009529:Nicardipine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D012984:Software; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000959:Antihypertensive Agents; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D009529:Nicardipine; C031215:betadex