title: Toll-like receptors: Role in inflammation and therapeutic potential.
abstract: Inflammation is an essential process in response to injury and infection. However, under certain circumstances dis-regulation of this process can lead to pathologies such as rheumatoid arthritis, atherosclerosis, lupus, and is a contributory factor in the progression of many cancers. The Toll-like family of receptors (TLRs) has major roles in the initiation of the inflammatory response and as such has attracted much focus for their potential as therapeutic targets. Here we review the role of TLRs in the inflammatory response and associated disease and examine how this important family of molecules might be targeted for therapeutic benefit.
authors.affiliation: Centre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
authors.forename: Emma
authors.initials: E
authors.lastname: Kay
authors.forename: Ramona S
authors.initials: RS
authors.lastname: Scotland
authors.forename: James R
authors.initials: JR
authors.lastname: Whiteford
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D054884:Host-Pathogen Interactions; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism; D018836:Inflammation Mediators / Q000502:physiology; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators; D051193:Toll-Like Receptors
keywords: DAMP; PAMP; inflammation; leukocyte; toll-like receptor