title: Monoclonal gammopathy of undetermined significance in pediatric kidney transplant: a possible role of Epstein-Barr virus.
abstract: MG is a common event of hematologic malignancies. There are many papers regarding kidney transplantation patients with MGUS in adults, while data in pediatrics are scarce. The etiology and clinical significance of MGUS are unclear both in adults and children. Immunosuppressive drugs, graft antigenicity, and viral infection could play a possible role. The viruses most frequently implicated seem to be EBV or CMV in particular, but their role has to be defined better. However, many investigators have emphasized an impaired balance between an adequate immune response and reactivation of viral infection.
authors.affiliation: Pediatric Nephrology and Dialysis Unit, Pediatric Hospital Giovanni XXIII, Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Giordano
authors.forename: L
authors.initials: L
authors.lastname: Santangelo
authors.forename: M L
authors.initials: ML
authors.lastname: Scarasciulli
authors.forename: A
authors.initials: A
authors.lastname: Calvario
authors.forename: G
authors.initials: G
authors.lastname: Miragliotta
authors.forename: P
authors.initials: P
authors.lastname: Giordano
authors.forename: V
authors.initials: V
authors.lastname: Cecinati
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D015331:Cohort Studies; D015897:Comorbidity; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000628:therapy; D005260:Female; D004854:Herpesvirus 4, Human; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications*; D051437:Renal Insufficiency / Q000150:complications* / Q000628:therapy*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents
keywords: Epstein-Barr virus; kidney transplant; monoclonal gammopathy; polymerase chain reaction