title: Nanofilaments on glioblastoma exosomes revealed by peak force microscopy.
abstract: Exosomes are sub-100 nm extracellular vesicles secreted by normal and cancer cells. We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, , Los Angeles, CA 90095, USA.
authors.forename: Shivani
authors.initials: S
authors.lastname: Sharma
authors.forename: Kingshuk
authors.initials: K
authors.lastname: Das
authors.forename: JungReem
authors.initials: J
authors.lastname: Woo
authors.forename: James K
authors.initials: JK
authors.lastname: Gimzewski
mesh_terms: D001696:Biomechanical Phenomena; D001703:Biophysics; D002450:Cell Communication / Q000502:physiology*; D045744:Cell Line, Tumor; D003599:Cytoskeleton / Q000648:ultrastructure*; D055354:Exosomes / Q000378:metabolism / Q000648:ultrastructure*; D005909:Glioblastoma / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D018625:Microscopy, Atomic Force / Q000379:methods; D008954:Models, Biological
keywords: glioblastoma exosomes; intercellular communication; nanofilaments; nanoparticles; nanotechnology