title: Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysis.
abstract: A continuous-flow, two-step procedure for the preparation of α-CF3-substituted carbonyl compounds has been developed. The carbonyl substrates were converted in situ into the corresponding silyl enol ethers, mixed with the CF3 radical source, and then irradiated with visible light using a flow reactor based on transparent tubing and a household compact fluorescent lamp. The continuous protocol uses Eosin Y as an inexpensive photoredox catalyst and requires only 20 min to complete the two reaction steps.
authors.affiliation: Institute of Chemistry, University of Graz , Heinrichstrasse 28, A-8010 Graz, Austria.
authors.forename: David
authors.initials: D
authors.lastname: Cantillo
authors.forename: Oscar
authors.initials: O
authors.lastname: de Frutos
authors.forename: Juan A
authors.initials: JA
authors.lastname: Rincón
authors.forename: Carlos
authors.initials: C
authors.lastname: Mateos
authors.forename: C Oliver
authors.initials: CO
authors.lastname: Kappe
mesh_terms: D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008027:Light; D008670:Metals / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure
chemical_list: D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D008670:Metals