title: Plant-based vaccines for Alzheimer's disease: an overview.
abstract: Plants are considered advantageous platforms for biomanufacturing recombinant vaccines. This constitutes a field of intensive research and some plant-derived vaccines are expected to be marketed in the near future. In particular, plant-based production of immunogens targeting molecules with implications on the pathology of Alzheimer's has been explored over the last decade. These efforts involve targeting amyloid beta and β-secretase with several immunogen configurations that have been evaluated in test animals. The results of these developments are analyzed in this review. Perspectives on the topic are identified, such as exploring additional antigen configurations and adjuvants in order to improve immunization schemes, characterizing in detail the elicited immune responses, and immunological considerations in the achievement of therapeutic humoral responses via mucosal immunization. Safety concerns related to these therapies will also be discussed.
authors.affiliation: Laboratorio de Biofarmacéuticos recombinantes, Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí , Av. Dr. Manuel Nava 6, SLP, 78210 , México.
authors.forename: Sergio
authors.initials: S
authors.lastname: Rosales-Mendoza
authors.forename: Néstor
authors.initials: N
authors.lastname: Rubio-Infante
authors.forename: Sergio
authors.initials: S
authors.lastname: Zarazúa
authors.forename: Dania O
authors.initials: DO
authors.lastname: Govea-Alonso
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Martel-Gallegos
authors.forename: Leticia
authors.initials: L
authors.lastname: Moreno-Fierros
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology / Q000517:prevention & control*; D023582:Alzheimer Vaccines / Q000276:immunology*; D053829:Amyloid Precursor Protein Secretases / Q000276:immunology*; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000818:Animals; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D018551:Solanum lycopersicum / Q000276:immunology / Q000378:metabolism; D051379:Mice; D012275:Oryza / Q000276:immunology / Q000378:metabolism; D008517:Phytotherapy / Q000379:methods*; D010942:Plant Viruses / Q000235:genetics; D011198:Solanum tuberosum / Q000276:immunology / Q000378:metabolism; D024801:Tauopathies / Q000235:genetics / Q000276:immunology; D014026:Nicotiana / Q000276:immunology / Q000378:metabolism; D014611:Vaccination; D016875:tau Proteins / Q000235:genetics / Q000276:immunology
chemical_list: D023582:Alzheimer Vaccines; D016229:Amyloid beta-Peptides; D016875:tau Proteins; D053829:Amyloid Precursor Protein Secretases