title: Characterizing human pancreatic cancer precursor using quantitative tissue optical spectroscopy.
abstract: In a pilot study, multimodal optical spectroscopy coupled with quantitative tissue-optics models distinguished intraductal papillary mucinous neoplasm (IPMN), a common precursor to pancreatic cancer, from normal tissues in freshly excised human pancreas. A photon-tissue interaction (PTI) model extracted parameters associated with cellular nuclear size and refractive index (from reflectance spectra) and extracellular collagen content (from fluorescence spectra). The results suggest that tissue optical spectroscopy has the potential to characterize pre-cancerous neoplasms in human pancreatic tissues.
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2099, USA.
authors.forename: Seung Yup
authors.initials: SY
authors.lastname: Lee
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2099, USA.
authors.forename: William R
authors.initials: WR
authors.lastname: Lloyd
authors.affiliation: Applied Physics Program, University of Michigan, Ann Arbor, MI 48109-1040, USA.
authors.forename: Malavika
authors.initials: M
authors.lastname: Chandra
authors.affiliation: Applied Physics Program, University of Michigan, Ann Arbor, MI 48109-1040, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Wilson
authors.affiliation: Department of Pathology, University of Michigan, Ann Arbor, MI 48109-0602, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: McKenna
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, MI 48109-5331, USA.
authors.forename: Diane
authors.initials: D
authors.lastname: Simeone
authors.affiliation: Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-0362, USA ; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109-0944, USA.
authors.forename: James
authors.initials: J
authors.lastname: Scheiman
authors.affiliation: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2099, USA ; Applied Physics Program, University of Michigan, Ann Arbor, MI 48109-1040, USA ; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109-0944, USA.
authors.forename: Mary-Ann
authors.initials: MA
authors.lastname: Mycek
keywords: (170.4580) Optical diagnostics for medicine; (170.6510) Spectroscopy, tissue diagnostics