title: Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats.
abstract: OBJECTIVE
  To investigate the effects of obesity and exercise training on regional adipose tissue angiogenesis and hypoxia markers in rats.
  
  
  METHODS
  Lean (Fa/Fa) and obese (fa/fa) male Zucker rats at 2 months of age were randomly assigned to a sedentary or an exercise training group (lean sedentary: n=7, lean exercise: n=8, obese sedentary: n=7, obese exercise: n=8). The exercise group walked on a rat treadmill 5 times per week for 8 weeks. Inguinal and epididymal adipose tissue vascular endothelial growth factor A (VEGF-A) and lactate levels were determined.
  
  
  RESULTS
  There were significant effects of obesity in increasing inguinal (P<0.001) and epididymal (P<0.05) adipose tissue VEGF-A, and a significant effect of exercise training in increasing epididymal adipose tissue VEGF-A (P<0.05). There was a significant effect of obesity in increasing inguinal adipose tissue lactate levels (P<0.001). Compared to lean sedentary animals, obese sedentary animals had significantly higher epididymal adipose tissue lactate levels (P<0.001); compared to obese sedentary animals, obese exercise rats had significantly lower epididymal adipose tissue lactate levels (P<0.05).
  
  
  CONCLUSIONS
  Exercise training increased adipose tissue VEGF-A, an important factor of tissue angiogenesis, and lowered adipose tissue lactate, an indicator of adipose tissue hypoxia in obese rats. However, these effects are depot-specific and only observed in intra-abdominal adipose tissue.
authors.affiliation: Department of Exercise and Nutrition Sciences, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, NY 14214.
authors.forename: Beth L
authors.initials: BL
authors.lastname: Disanzo
authors.affiliation: Department of Exercise and Health Sciences, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA 02125. Electronic address: tongjian.you@umb.edu.
authors.forename: Tongjian
authors.initials: T
authors.lastname: You
mesh_terms: D000273:Adipose Tissue / Q000098:blood supply*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D000860:Hypoxia / Q000503:physiopathology*; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D009389:Neovascularization, Pathologic; D009765:Obesity / Q000503:physiopathology*; D010805:Physical Conditioning, Animal; D051381:Rats; D011924:Rats, Zucker; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A; D019344:Lactic Acid
keywords: Fat tissue; Lactate; Obesity; Treadmill walking; VEGF-A