title: NH-type of chiral Ni(II) complexes of glycine Schiff base: design, structural evaluation, reactivity and synthetic applications.
abstract: The work being reported here deals with the design of a new type of "N-H" Ni(II) complexes of glycine Schiff bases and study general aspects of their reactivity. It was confirmed that the presence of NH function in these Ni(II) complexes does not interfere with the homologation of the glycine residue, rendering these derivatives of high synthetic value for the general synthesis of α-amino acids. In particular, the practical application of these NH-type complexes was demonstrated by asymmetric synthesis of various β-substituted pyroglutamic acids via Michael addition reactions with chiral Michael acceptors.
authors.affiliation: Department of Chemistry and Physics, Southwestern Oklahoma State University, 100 Campus Drive, Weatherford, OK 73096-3098, USA.
authors.forename: Mackenzie
authors.initials: M
authors.lastname: Bergagnini
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Fukushi
authors.forename: Jianlin
authors.initials: J
authors.lastname: Han
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata
authors.forename: Christian
authors.initials: C
authors.lastname: Roussel
authors.forename: Trevor K
authors.initials: TK
authors.lastname: Ellis
authors.forename: José Luis
authors.initials: JL
authors.lastname: Aceña
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Soloshonok
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005998:Glycine / Q000737:chemistry*; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry*; D011761:Pyrrolidonecarboxylic Acid / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D056831:Coordination Complexes; D012545:Schiff Bases; D009532:Nickel; D011761:Pyrrolidonecarboxylic Acid; D005998:Glycine