title: Proteoglycans and glycosaminoglycans improve toughness of biocompatible double network hydrogels.
abstract: Based on the molecular stent concept, a series of tough double-network hydrogels (St-DN gels) made from the components of proteoglycan aggregates - chondroitin sulfate proteoglycans (1), chondroitin sulfate (2), and sodium hyaluronate (3) - are successfully developed in combination with a neutral biocompatible polymer. This work demonstrates a promising method to create biopolymer-based tough hydrogels for biomedical applications.
authors.affiliation: Laboratory of Soft & Wet Matter, Graduate School of Life Science, Hokkaido University, Kita-10-Nishi-8, Kita-ku, Sapporo, 060-0810, Japan.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Tasuku
authors.initials: T
authors.lastname: Nakajima
authors.forename: Jing Jing
authors.initials: JJ
authors.lastname: Yang
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kurokawa
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Jishun
authors.initials: J
authors.lastname: Lu
authors.forename: Shuji
authors.initials: S
authors.lastname: Mizumoto
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sugahara
authors.forename: Nobuto
authors.initials: N
authors.lastname: Kitamura
authors.forename: Kazunori
authors.initials: K
authors.lastname: Yasuda
authors.forename: A U D
authors.initials: AU
authors.lastname: Daniels
authors.forename: Jian Ping
authors.initials: JP
authors.lastname: Gong
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D001698:Biomedical Engineering / Q000379:methods; D001704:Biopolymers / Q000737:chemistry; D002356:Cartilage / Q000737:chemistry; D002478:Cells, Cultured; D011508:Chondroitin Sulfate Proteoglycans / Q000737:chemistry*; D002809:Chondroitin Sulfates / Q000737:chemistry*; D049832:Decapodiformes; D055119:Elastic Modulus; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008970:Molecular Weight; D009997:Osmotic Pressure; D011108:Polymers / Q000737:chemistry*; D012474:Salmon; D018502:Streptococcus equi; D013718:Tensile Strength
chemical_list: D000178:Acrylamides; D001672:Biocompatible Materials; D001704:Biopolymers; D011508:Chondroitin Sulfate Proteoglycans; D020100:Hydrogels; D011108:Polymers; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates; C099046:N,N-dimethylacrylamide
keywords: biocompatibility; glycosaminoglycans; hydrogels; proteoglycans; toughness