title: Suppressors of cytokine signaling (SOCS) and type 2 diabetes.
abstract: The suppressors of cytokine signaling (SOCS) proteins are originally identified as negative regulators of cytokine-activated Janus kinase/signal transducers and activators of transcription signaling pathway, but increasing evidence reveals that SOCS proteins play an important role in the development of type 2 diabetes involving regulation of the insulin signaling and pancreatic β-cell function, and that SOCS are promising to be the targets for the treatment of type 2 diabetes. In this review, we focus on the emerging role for SOCS and the potential drugs targeting SOCS for type 2 diabetes.
authors.affiliation: Guangxi Scientific Experimental Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning, 530001, People's Republic of China.
authors.forename: Xiaotao
authors.initials: X
authors.lastname: Feng
authors.forename: Hongzhen
authors.initials: H
authors.lastname: Tang
authors.forename: Jing
authors.initials: J
authors.lastname: Leng
authors.forename: Qiuyan
authors.initials: Q
authors.lastname: Jiang
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D055504:Insulin Receptor Substrate Proteins / Q000378:metabolism; D000078790:Insulin Secretion; D005810:Multigene Family; D059748:Proteolysis; D015398:Signal Transduction; D050826:Suppressor of Cytokine Signaling Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination
chemical_list: D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; D050826:Suppressor of Cytokine Signaling Proteins