title: Immune response to mutant neo-antigens: Cancer's lessons for aging.
abstract: Extending observations on the immunogenicity of neo-antigens that arise in the course of oncogenesis and tumor progression, we suggest that somatic mutations affecting normal tissues also lead to generation of new epitopes. We hypothesize that, at least under inflammatory conditions, immune responses against such neo-antigens may lead to the elimination or functional impairment of normal cells, thus contributing to aging.
authors.affiliation: Department of Immunology; University of Connecticut School of Medicine; Farmington, CT USA ; Carole and Ray Neag Comprehensive Cancer Center; University of Connecticut School of Medicine; Farmington, CT USA.
authors.forename: Rory J
authors.initials: RJ
authors.lastname: Geyer
authors.affiliation: Department of Immunology; University of Connecticut School of Medicine; Farmington, CT USA ; Carole and Ray Neag Comprehensive Cancer Center; University of Connecticut School of Medicine; Farmington, CT USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Tobet
authors.affiliation: Department of Immunology; University of Connecticut School of Medicine; Farmington, CT USA ; Carole and Ray Neag Comprehensive Cancer Center; University of Connecticut School of Medicine; Farmington, CT USA.
authors.forename: Richard D
authors.initials: RD
authors.lastname: Berlin
authors.affiliation: Department of Immunology; University of Connecticut School of Medicine; Farmington, CT USA ; Carole and Ray Neag Comprehensive Cancer Center; University of Connecticut School of Medicine; Farmington, CT USA.
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Srivastava
keywords: cancer; ignorance; infection; inflammation; injury; tolerance