title: Ionone glycosides from the roots of Rehmannia glutinosa.
abstract: Four new ionone and ionone glycosides (1-4), and a new monoterpene (5), together with 10 known analogues (6-15), were isolated from the air-dried roots of Rehmannia glutinosa. The structures of these compounds were elucidated on the basis of spectroscopic data analysis. Furthermore, in in vitro assays, compound 3 (10 μM) exhibited moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage.
authors.affiliation: a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , 100050 , China.
authors.forename: Yan-Fei
authors.initials: YF
authors.lastname: Liu
authors.forename: Dong
authors.initials: D
authors.lastname: Liang
authors.forename: Huan
authors.initials: H
authors.lastname: Luo
authors.forename: Zhi-You
authors.initials: ZY
authors.lastname: Hao
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Chun-Lei
authors.initials: CL
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: Ni
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005688:Galactosamine / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D045792:Norisoprenoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D032267:Rehmannia / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D045792:Norisoprenoids; D005688:Galactosamine