title: Association of the APOE, MTHFR and ACE Genes Polymorphisms and Stroke in Zambian Patients.
abstract: The aim of the present study was to investigate the association of APOE, MTHFR and ACE polymorphisms with stroke in the Zambian population. We analyzed 41 stroke patients and 116 control subjects all of Zambian origin for associations between the genotype of the APOE, MTHFR and ACE polymorphisms and stroke. The APOE ε2ε4 genotype showed increased risk for hemorrhagic stroke (P<0.05) and also a high risk for ischemic stroke (P=0.05). There was complete absence of the APOE ε2ε2 and the MTHFR TT genotypes in the Zambian population. The difference between cases and controls was not significant for the other genetic variants when analyzed for relationship between stroke, stroke subtype and genotype. We show that genetic variation at the APOE locus affects susceptibility to stroke. No detectable association were observed for the MTHFR and ACE genotypes and stroke in the Zambian population.
authors.affiliation: Department of Internal Medicine, School of Medicine, University of Zambia, Lusaka, Zambia; Departments of.
authors.forename: Masharip
authors.initials: M
authors.lastname: Atadzhanov
authors.affiliation: Department of Internal Medicine, School of Medicine, University of Zambia, Lusaka, Zambia; Departments of.
authors.forename: Mwila H
authors.initials: MH
authors.lastname: Mwaba
authors.affiliation: Department of Internal Medicine, School of Medicine, University of Zambia, Lusaka, Zambia; Departments of.
authors.forename: Patrice N
authors.initials: PN
authors.lastname: Mukomena
authors.affiliation: Department of Internal Medicine, School of Medicine, University of Zambia, Lusaka, Zambia; Departments of.
authors.forename: Shabir
authors.initials: S
authors.lastname: Lakhi
authors.affiliation: Neuroscience.
authors.forename: Sruti
authors.initials: S
authors.lastname: Rayaprolu
authors.affiliation: Neuroscience.
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
authors.affiliation: Neurology, Mayo Clinic , Jacksonville, FL, USA.
authors.forename: James F
authors.initials: JF
authors.lastname: Meschia
keywords: Sub-Saharan Africa; Zambia; intra-cerebral hemorrhage; ischemic stroke; outcome; risks factors