title: Negative interactions and feedback regulations are required for transient cellular response.
abstract: Signal transduction is a process required to conduct information from a receptor to the nucleus. This process is vital for the control of cellular function and fate. The dynamics of signaling activation and inhibition determine processes such as apoptosis, proliferation, and differentiation. Thus, it is important to understand the factors modulating transient and sustained response. To address this question, by applying mathematical approach we have studied the factors which can alter the activation nature of downstream signaling molecules. The factors which we have investigated are loops (feed forward and feedback loops), cross-talk of signal transduction pathways, and the change in the concentration of the signaling molecules. Based on our results we conclude that among these factors feedback loop and the cross-talks which directly inhibit the target protein dominantly controls the transient cellular response.
authors.affiliation: Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, 39120, Magdeburg, Germany.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mobashir
authors.affiliation: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University, 39120, Magdeburg, Germany.
authors.forename: Thati
authors.initials: T
authors.lastname: Madhusudhan
authors.affiliation: Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke University, 39120, Magdeburg, Germany.
authors.forename: Berend
authors.initials: B
authors.lastname: Isermann
authors.affiliation: Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, 39120, Magdeburg, Germany.
authors.forename: Tilo
authors.initials: T
authors.lastname: Beyer
authors.affiliation: 1] Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, 39120, Magdeburg, Germany [2] Department of Immune Control, Helmholtz Centre for Infectious Disease (HZI), Inhoffenstrasse 7, 38124 Braunschweig, Germany.
authors.forename: Burkhart
authors.initials: B
authors.lastname: Schraven
mesh_terms: D002468:Cell Physiological Phenomena; D025461:Feedback, Physiological; D008954:Models, Biological; D015398:Signal Transduction