title: 1-Oleoyl lysophosphatidic acid: a new mediator of emotional behavior in rats.
abstract: The role of lysophosphatidic acid (LPA) in the control of emotional behavior remains to be determined. We analyzed the effects of the central administration of 1-oleoyl-LPA (LPA 18∶1) in rats tested for food consumption and anxiety-like and depression-like behaviors. For this purpose, the elevated plus-maze, open field, Y maze, forced swimming and food intake tests were performed. In addition, c-Fos expression in the dorsal periaqueductal gray matter (DPAG) was also determined. The results revealed that the administration of LPA 18∶1 reduced the time in the open arms of the elevated plus-maze and induced hypolocomotion in the open field, suggesting an anxiogenic-like phenotype. Interestingly, these effects were present following LPA 18∶1 infusion under conditions of novelty but not under habituation conditions. In the forced swimming test, the administration of LPA 18∶1 dose-dependently increased depression-like behavior, as evaluated according to immobility time. LPA treatment induced no effects on feeding. However, the immunohistochemical analysis revealed that LPA 18∶1 increased c-Fos expression in the DPAG. The abundant expression of the LPA1 receptor, one of the main targets for LPA 18∶1, was detected in this brain area, which participates in the control of emotional behavior, using immunocytochemistry. These findings indicate that LPA is a relevant transmitter potentially involved in normal and pathological emotional responses, including anxiety and depression.
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain ; Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Universidad de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
authors.forename: Estela
authors.initials: E
authors.lastname: Castilla-Ortega
authors.affiliation: Departamento de Psicobiología, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Leticia
authors.initials: L
authors.lastname: Escuredo
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Bilbao
authors.affiliation: Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Universidad de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Pedraza
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain ; Departamento de Psicobiología, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Orio
authors.affiliation: Unidad de Gestión Clínica de Neurociencias, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
authors.forename: Guillermo
authors.initials: G
authors.lastname: Estivill-Torrús
authors.affiliation: Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Universidad de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Santín
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain ; Departamento de Psicobiología, Universidad Complutense de Madrid, Madrid, Spain.
authors.forename: Fernando Rodríguez
authors.initials: FR
authors.lastname: de Fonseca
authors.affiliation: Unidad de Gestión Clínica de Salud Mental, Hospital Regional Universitario de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Pavón
mesh_terms: D000818:Animals; D001007:Anxiety / Q000139:chemically induced; D001522:Behavior, Animal / Q000187:drug effects; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D005247:Feeding Behavior / Q000187:drug effects; D008246:Lysophospholipids / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D010487:Periaqueductal Gray / Q000187:drug effects / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism; D051381:Rats; D049368:Receptors, Lysophosphatidic Acid / Q000378:metabolism
chemical_list: D008246:Lysophospholipids; D016760:Proto-Oncogene Proteins c-fos; D049368:Receptors, Lysophosphatidic Acid; C032881:lysophosphatidic acid