title: Osteochondral tissue engineering with biphasic scaffold: current strategies and techniques.
abstract: The management of osteoarthritis (OA) remains challenging and controversial. Although several clinical options exist for the treatment of OA, regeneration of the damaged articular cartilage has proved difficult due to the limited healing capacity. With the advancements in tissue engineering and cell-based technologies over the past decade, new therapeutic options for patients with osteochondral lesions potentially exist. This review will focus on the feasibility of tissue-engineered biphasic scaffolds, which can mimic the native osteochondral complex, for osteochondral repair and highlight the recent development of these techniques toward tissue regeneration. Moreover, basic anatomy, strategy for osteochondral repair, the design and fabrication methods of scaffolds, as well as the choice of cells, growth factor, and materials will be discussed. Specifically, we focus on the latest preclinical animal studies using large animals and clinical trials with high clinical relevance. In turn, this will facilitate an understanding of the latest trends in osteochondral repair and contribute to the future application of such clinical therapies in patients with OA.
authors.affiliation: 1 Department of Orthopaedics, Osaka University Graduate School of Medicine , Osaka, Japan .
authors.forename: Kazunori
authors.initials: K
authors.lastname: Shimomura
authors.forename: Yu
authors.initials: Y
authors.lastname: Moriguchi
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Murawski
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Norimasa
authors.initials: N
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology / Q000502:physiology*; D002986:Clinical Trials as Topic; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014945:Wound Healing / Q000187:drug effects
chemical_list: D036341:Intercellular Signaling Peptides and Proteins