title: Diastereoselective three-component reactions of chiral nickel(II) glycinate for convenient synthesis of novel α-amino-β-substituted-γ,γ-disubstituted butyric acids.
abstract: The convenient, high yielding and diastereoselective synthesis of α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives was carried out by a three-component tandem reaction of a chiral equivalent of nucleophilic glycine. The reaction was performed smoothly under mild conditions and enabled the construction of two or three adjacent chiral centers in one step, thus affording a novel and convenient route to α-amino-β-substituted-γ,γ-disubstituted butyric acid derivatives.
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, and West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China. sklb_zhourui@126.com.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhou
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, and West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China. guoli@scu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Guo
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, and West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China. pengchengchengdu@126.com.
authors.forename: Cheng
authors.initials: C
authors.lastname: Peng
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, and West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China. hegu@scu.edu.cn.
authors.forename: Gu
authors.initials: G
authors.lastname: He
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, and West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China. ouyangliang@scu.edu.cn.
authors.forename: Liang
authors.initials: L
authors.lastname: Ouyang
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, and West China School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China. huangwei@cdutcm.edu.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
mesh_terms: D002087:Butyrates / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D005998:Glycine / Q000031:analogs & derivatives* / Q000145:classification*; D008956:Models, Chemical; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002087:Butyrates; D012545:Schiff Bases; D009532:Nickel; D005998:Glycine