title: Regional neuroplastic brain changes in patients with chronic inflammatory and non-inflammatory visceral pain.
abstract: Regional cortical thickness alterations have been reported in many chronic inflammatory and painful conditions, including inflammatory bowel diseases (IBD) and irritable bowel syndrome (IBS), even though the mechanisms underlying such neuroplastic changes remain poorly understood. In order to better understand the mechanisms contributing to grey matter changes, the current study sought to identify the differences in regional alterations in cortical thickness between healthy controls and two chronic visceral pain syndromes, with and without chronic gut inflammation. 41 healthy controls, 11 IBS subjects with diarrhea, and 16 subjects with ulcerative colitis (UC) underwent high-resolution T1-weighted magnetization-prepared rapid acquisition gradient echo scans. Structural image preprocessing and cortical thickness analysis within the region of interests were performed by using the Laboratory of Neuroimaging Pipeline. Group differences were determined using the general linear model and linear contrast analysis. The two disease groups differed significantly in several cortical regions. UC subjects showed greater cortical thickness in anterior cingulate cortical subregions, and in primary somatosensory cortex compared with both IBS and healthy subjects. Compared with healthy subjects, UC subjects showed lower cortical thickness in orbitofrontal cortex and in mid and posterior insula, while IBS subjects showed lower cortical thickness in the anterior insula. Large effects of correlations between symptom duration and thickness in the orbitofrontal cortex and postcentral gyrus were only observed in UC subjects. The findings suggest that the mechanisms underlying the observed gray matter changes in UC subjects represent a consequence of peripheral inflammation, while in IBS subjects central mechanisms may play a primary role.
authors.affiliation: Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America.
authors.forename: Jui-Yang
authors.initials: JY
authors.lastname: Hong
authors.affiliation: Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Labus
authors.affiliation: Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, United States of America ; Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Jiang
authors.affiliation: Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
authors.forename: Cody
authors.initials: C
authors.lastname: Ashe-Mcnalley
authors.affiliation: University of Michigan School of Nursing, Ann Arbor, Michigan, United States of America.
authors.forename: Ivo
authors.initials: I
authors.lastname: Dinov
authors.affiliation: Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
authors.forename: Arpana
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Laboratory of Neuro-Imaging, University of Southern California, Los Angeles, California United States of America.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
authors.forename: Jean
authors.initials: J
authors.lastname: Stains
authors.affiliation: Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
authors.forename: Nuwanthi
authors.initials: N
authors.lastname: Heendeniya
authors.affiliation: Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
authors.forename: Suzanne R
authors.initials: SR
authors.lastname: Smith
authors.affiliation: Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America.
authors.forename: Kirsten
authors.initials: K
authors.lastname: Tillisch
authors.affiliation: Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, University of California Los Angeles, Los Angeles, California, United States of America ; Pain and Interoception Imaging Network (PAIN), University of California Los Angeles, Los Angeles, California, United States of America ; Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America ; Department of Psychiatry, University of California Los Angeles, Los Angeles, California, United States of America ; Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America ; Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California, United States of America ; Ahmanson Lovelace Brain Mapping Center, David Geffen School of Medicine, University of California, Los Angeles, California.
authors.forename: Emeran A
authors.initials: EA
authors.lastname: Mayer
mesh_terms: D000328:Adult; D001519:Behavior; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D016022:Case-Control Studies; D003071:Cognition; D003093:Colitis, Ulcerative / Q000150:complications*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging; D009473:Neuronal Plasticity; D009929:Organ Size; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D059265:Visceral Pain / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult