title: Horizon scanning for translational genomic research beyond bench to bedside.
abstract: OBJECTIVE
  The dizzying pace of genomic discoveries is leading to an increasing number of clinical applications. In this report, we provide a method for horizon scanning and 1 year data on translational research beyond bench to bedside to assess the validity, utility, implementation, and outcomes of such applications.
  
  
  METHODS
  We compiled cross-sectional results of ongoing horizon scanning of translational genomic research, conducted between 16 May 2012 and 15 May 2013, based on a weekly, systematic query of PubMed. A set of 505 beyond bench to bedside articles were collected and classified, including 312 original research articles; 123 systematic and other reviews; 38 clinical guidelines, policies, and recommendations; and 32 articles describing tools, decision support, and educational materials.
  
  
  RESULTS
  Most articles (62%) addressed a specific genomic test or other health application; almost half of these (n = 180) were related to cancer. We estimate that these publications account for 0.5% of reported human genomics and genetics research during the same time.
  
  
  CONCLUSIONS
  These data provide baseline information to track the evolving knowledge base and gaps in genomic medicine. Continuous horizon scanning of the translational genomics literature is crucial for an evidence-based translation of genomics discoveries into improved health care and disease prevention.
authors.affiliation: 1] Kelly Services, Troy, Michigan, USA [2] Epidemiology and Genomics Research Program, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Mindy
authors.initials: M
authors.lastname: Clyne
authors.affiliation: Epidemiology and Genomics Research Program, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: Sheri D
authors.initials: SD
authors.lastname: Schully
authors.affiliation: Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: W David
authors.initials: WD
authors.lastname: Dotson
authors.affiliation: 1] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA [2] McKing Consulting Corporation, Atlanta, Georgia, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Douglas
authors.affiliation: 1] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA [2] McKing Consulting Corporation, Atlanta, Georgia, USA.
authors.forename: Marta
authors.initials: M
authors.lastname: Gwinn
authors.affiliation: Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Kolor
authors.affiliation: 1] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA [2] Cadence Group, Atlanta, Georgia, USA.
authors.forename: Anja
authors.initials: A
authors.lastname: Wulf
authors.affiliation: Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: M Scott
authors.initials: MS
authors.lastname: Bowen
authors.affiliation: 1] Epidemiology and Genomics Research Program, National Cancer Institute, Bethesda, Maryland, USA [2] Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
authors.forename: Muin J
authors.initials: MJ
authors.lastname: Khoury
mesh_terms: D003430:Cross-Sectional Studies; D003661:Decision Support Techniques; D019317:Evidence-Based Medicine; D023281:Genomics; D006801:Humans; D033181:Information Dissemination; D015201:Meta-Analysis as Topic; D057170:Translational Research, Biomedical