title: Monoterpenoids from the whole herb of Veronicastrum axillare.
abstract: BACKGROUND
  Veronicastrum axillare (Sieb. et Zucc.) Yamazaki (Scrophulariaceae) embraces varieties of bioactivities such as anti-inflammatory, anti-pyresis and detoxification activity, while little is known of the phytochemical components of this medicinal plant.
  
  
  OBJECTIVE
  To isolate and identify bioactive constituents from the whole herb of V. axillare.
  
  
  METHODS
  Ethanol extract of the whole herb of V. axillare was subjected to successive column chromatography. Chemical structures of the compounds were elucidated by detailed spectroscopic analyses on the basis of NMR, IR and HR-MS data.
  
  
  RESULTS
  A new monoterpenoid, axillacetal A (1) and a known analogue, tarumal (2), were isolated from the whole herb of V. axillare. The structure of tarumal (2) was also revised according to our NMR data.
  
  
  CONCLUSIONS
  This is the first report on the isolation and authentication of novel chemical constituents from V. axillare.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Second Military Medical University , Shanghai , PR China .
authors.forename: Xue-Hong
authors.initials: XH
authors.lastname: Deng
authors.forename: Fan-Fu
authors.initials: FF
authors.lastname: Fang
authors.forename: Cheng-Jian
authors.initials: CJ
authors.lastname: Zheng
authors.forename: Yu
authors.initials: Y
authors.lastname: Wu
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Qin
mesh_terms: D000085:Acetates / Q000302:isolation & purification*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000302:isolation & purification*; D002855:Chromatography, Thin Layer; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D039821:Monoterpenes / Q000302:isolation & purification*; D028083:Scrophulariaceae / Q000737:chemistry*
chemical_list: D000085:Acetates; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004365:Drugs, Chinese Herbal; D039821:Monoterpenes