title: RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions.
abstract: A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role played by RAB GTPases and their effector proteins on neuronal development and the shaping of cognitive functions. This review is highlighting these initial elements to broaden the current scope of research on developmental cognitive deficits and take the point of view of RAB GTPases control on membrane transport in neurons and astrocytes.
authors.affiliation: Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Neuroscience, via Olgettina 58, 20132 Milan, Italy; Vita-Salute San Raffaele University, via Olgettina 58, 20132 Milan, Italy. Electronic address: p.dadamo@hsr.it.
authors.forename: Patrizia
authors.initials: P
authors.lastname: D'Adamo
authors.affiliation: Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Neuroscience, via Olgettina 58, 20132 Milan, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Masetti
authors.affiliation: Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Neuroscience, via Olgettina 58, 20132 Milan, Italy; Vita-Salute San Raffaele University, via Olgettina 58, 20132 Milan, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Bianchi
authors.affiliation: Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Neuroscience, via Olgettina 58, 20132 Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Morè
authors.affiliation: Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Neuroscience, via Olgettina 58, 20132 Milan, Italy; Vita-Salute San Raffaele University, via Olgettina 58, 20132 Milan, Italy.
authors.forename: Maria Lidia
authors.initials: ML
authors.lastname: Mignogna
authors.affiliation: Dulbecco Telethon Institute at San Raffaele Scientific Institute, Division of Neuroscience, via Olgettina 58, 20132 Milan, Italy; F. Hoffmann-La Roche AG, pRED Pharma Research & Early Development, DTA Neuroscience Grenzacherstrasse 124, Basel CH4070, Switzerland.
authors.forename: Maila
authors.initials: M
authors.lastname: Giannandrea
authors.affiliation: F. Hoffmann-La Roche AG, pRED Pharma Research & Early Development, DTA Neuroscience Grenzacherstrasse 124, Basel CH4070, Switzerland.
authors.forename: Silvia
authors.initials: S
authors.lastname: Gatti
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D049990:Membrane Transport Modulators / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D011485:Protein Binding; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D049990:Membrane Transport Modulators; D009419:Nerve Tissue Proteins; D020691:rab GTP-Binding Proteins
keywords: Brain development; G proteins; GDI1; GTPase; Intellectual disability; RAB