title: Preparation of a novel organo-soluble chitosan grafted polycaprolactone copolymer for drug delivery.
abstract: The unsatisfactory solubility of chitosan has been a key barrier to its modification and application. To improve its solubility, a novel organo-soluble glycidol grafted chitosan was developed as a potential material for bio-related applications. The hydrophilic glycidol was grafted onto the amino groups of chitosan via a facile and "green" aqueous reaction. The grafting levels of glycidol strongly influenced the organo-solubility and water-solubility of the chitosan due to the inhibition of its intermolecular interactions. The resulting glycidol grafted chitosan (Gly-HCS and Gly-LCS) was directly dissolved in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF). Taking advantage of the improved organo-solubility, an amphiphilic Gly-LCS grafted polycaprolactone (GC-g-PCL) copolymer and its assembly were prepared as an efficient anti-tumour doxorubicin (DOX) carrier. The DOX loaded GC-g-PCL assembly exhibited a control release profile and anti-tumour activity. Acting as a basic substrate, this organo-soluble chitosan derivative has the potential to meet a wide range of requirements in the field of biological macromolecules.
authors.affiliation: Qingdao Municipal Hospital, Qingdao 266011, PR China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.affiliation: School of Chemistry and Environment, Beihang University, Beijing 100191, PR China. Electronic address: caocmy@gmail.com.
authors.forename: Moyuan
authors.initials: M
authors.lastname: Cao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry* / Q000633:toxicity; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D004126:Dimethylformamide / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000633:toxicity; D004852:Epoxy Compounds / Q000737:chemistry; D056945:Hep G2 Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D011091:Polyesters / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D004852:Epoxy Compounds; D011091:Polyesters; D020005:Propanols; C016240:polycaprolactone; D004317:Doxorubicin; D004126:Dimethylformamide; D048271:Chitosan; C004312:glycidol; D004121:Dimethyl Sulfoxide
keywords: Amphiphilic copolymer; Chitosan; Drug delivery system