title: Therapeutic implications of immunogenic cell death in human cancer.
abstract: Dendritic cells (DCs) are central to the adoptive immune response, and their function is regulated by diverse signals in a context-specific manner. Different DCs have been described in physiologic conditions, inflammation, and cancer, prompting a series of questions on how adoptive immune responses, or tolerance, develop against tumors. Increasing evidence suggests that tumor treatments induce a dramatic change on tumor-infiltrating lymphocytes and, in particular, on some DC subtypes. In this review, we summarize the latest evidence on the role of DCs in cancer and preliminary evidence on chemotherapy-associated antigens identified in human cancers.
authors.affiliation: Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma , Rome , Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Palombo
authors.affiliation: Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma , Rome , Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Focaccetti
authors.affiliation: Dipartimento di Medicina Interna e Specialità Mediche, Sapienza Università di Roma , Rome , Italy ; Istituto Pasteur - Fondazione Cenci Bolognetti , Rome , Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Barnaba
keywords: chemotherapy; dendritic cells, T cells; immunogenic cell death; tumor antigens