title: Emblica officinalis improves glycemic status and oxidative stress in STZ induced type 2 diabetic model rats.
abstract: OBJECTIVE
  To evaluate the antidiabetic and antioxidant potential of Emblica officinalis (E. officinalis) fruit on normal and type 2 diabetic rats.
  
  
  METHODS
  Type 2 diabetes was induced into the male Long-Evans rats. The rats were divided into nine groups including control groups receiving water, type 2 diabetic controls, type 2 diabetic rats treated with glibenclamide (T2GT) and type 2 diabetic rats treated with aqueous extract of fruit pulp of E. officinalis. They were fed orally for 8 weeks with a single feeding. Blood was collected by cutting the tail tip on 0 and 28 days and by decapitation on 56 day. Packed red blood cells and serum were used for evaluating different biochemical parameters.
  
  
  RESULTS
  Four weeks administration of aqueous extract of E. officinalis improved oral glucose tolerance in type 2 rats and after 8 weeks it caused significant (P<0.007) reduction in fasting serum glucose level compared to 0 day. Triglycerides decreased by 14% but there was no significant change in serum ALT, creatinine, cholesterol and insulin level in any group. Furthermore, reduced erythrocyte malondialdehyde level showed no significant change (P<0.07) but reduced glutathione content was found to be increased significantly (P<0.05).
  
  
  CONCLUSIONS
  The aqueous extract of E. officinalis has a promising antidiabetic and antioxidant properties and may be considered for further clinical studies in drug development.
authors.affiliation: Department of Genetic Engineering and Biotechnology, Jessore Science and Technology University, Jessore, Bangladesh.
authors.forename: Aneesa
authors.initials: A
authors.lastname: Ansari
authors.affiliation: Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia, Bangladesh.
authors.forename: Md Shahed Zaman
authors.initials: MS
authors.lastname: Shahriar
authors.affiliation: Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia, Bangladesh; Department of Biomedical Science, Chonbuk National University Medical School, Jeonju 561-712, South Korea.
authors.forename: Md Mehedi
authors.initials: MM
authors.lastname: Hassan
authors.affiliation: Department of Biochemistry and Molecular Biology, Hajee Mohammad Danesh Science & Technology University, Dinajpur, Bangladesh.
authors.forename: Shukla Rani
authors.initials: SR
authors.lastname: Das
authors.affiliation: Department of Biochemistry and Cell Biology, Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM), Dhaka, Bangladesh.
authors.forename: Begum
authors.initials: B
authors.lastname: Rokeya
authors.affiliation: Department of Biotechnology and Genetic Engineering, Islamic University, Kushtia, Bangladesh.
authors.forename: Md Anwarul
authors.initials: MA
authors.lastname: Haque
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka-1000, Bangladesh.
authors.forename: Md Enamul
authors.initials: ME
authors.lastname: Haque
authors.affiliation: Department of Nutrition and Food Sciences, University of Huddersfield, Huddersfiled, HD1 3DH, United Kingdom. Electronic address: nirupamgene@gmail.com.
authors.forename: Nirupam
authors.initials: N
authors.lastname: Biswas
authors.affiliation: Department of Applied Nutrition and Food Technology, Islamic University, Kushtia, Bangladesh.
authors.forename: Tama
authors.initials: T
authors.lastname: Sarkar
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005947:Glucose / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D029842:Phyllanthus emblica / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D008315:Malondialdehyde; D003404:Creatinine; D000410:Alanine Transaminase; D005978:Glutathione; D005947:Glucose
keywords: Antidiabetic; Antioxidant; Emblica officinalis; Non-insulin dependent diabetes mellitus; Reduced glutathione; Type 2 diabetic rats