title: [Effect of sijunzi decoction on the intestinal glucose absorption in model rats of Pi-qi deficiency syndrome: an experimental research].
abstract: OBJECTIVE
  To observe the effect of Sijunzi Decoction (SD) on the intestinal absorption of glucose in model rats of Pi-qi deficiency syndrome (PQDS).
  
  
  METHODS
  PQDS rat model was established by subcutaneous injection of reserpine from the neck. The body weight and urine D-xylose excretion rates were measured. The glucose uptake rate was measured by jejunum perfusion. The intestinal mucosa was collected. The glucose transporter-2 (GLUT2) protein and mRNA expression levels were detected.
  
  
  RESULTS
  Compared with the normal control group, the body weight and D-xylose excretion rates decreased in the model group. Meanwhile, the glucose uptake and GLUT2 protein and mRNA expression levels decreased in the model group. The aforesaid indices were improved in the SD group.
  
  
  CONCLUSIONS
  SD could promote the recovery of glucose uptake in the small intestine of reserpine induced PQDS rats.
authors.affiliation: Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Wen-Feng
authors.initials: WF
authors.lastname: Guo
authors.affiliation: Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Li
authors.initials: L
authors.lastname: Ren
authors.affiliation: Pi-Wei Institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.
authors.forename: Wei-Wen
authors.initials: WW
authors.lastname: Chen
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D051273:Glucose Transporter Type 2 / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D019413:Qi; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000009:adverse effects
chemical_list: D004365:Drugs, Chinese Herbal; D051273:Glucose Transporter Type 2; C495683:Slc2a2 protein, rat; D012110:Reserpine; D005947:Glucose