title: Vaccination and occurrence of seizures in SCN1A mutation-positive patients: a multicenter Italian study.
abstract: BACKGROUND
  The relation between epileptic seizures and vaccinations is sometimes debated. In the present work, the impact of vaccination on seizure onset and clinical outcome of SCN1A mutation-positive patients is addressed.
  
  
  METHODS
  Seventy-two patients diagnosed with Dravet syndrome or generalized epilepsy with febrile seizure plus, carrying SCN1A mutations or not, were included. Details on vaccination type, temporal relationship between vaccination and seizure occurrence, seizure type at onset and during development, cognitive functioning, and vaccination completion was obtained by reviewing clinical records. Patients were divided into two groups based on the temporal window between vaccination and seizure onset (proximate group: <48 hours; distant group: >48 hours).
  
  
  RESULTS
  Vaccination-related seizures occurred in 25% of patients with SCN1A mutation and 18% of patients without the mutation (no significant difference). The proximate group showed an earlier age at seizure onset and a higher frequency of status epilepticus during development than did the distant group. No other significant differences were found. Subsequent vaccinations did not significantly alter the evolution of the disease.
  
  
  CONCLUSIONS
  Results from this relatively small series provide evidence that vaccinations do not significantly affect clinical and cognitive evolution of Dravet syndrome and generalized epilepsy with febrile seizure plus patients even if they carry SCN1A mutations.
authors.affiliation: Department of Pediatric Neurology, Ospedali Riuniti, Ancona, Italy.
authors.forename: Nelia
authors.initials: N
authors.lastname: Zamponi
authors.affiliation: Department of Pediatric Neurology, Ospedali Riuniti, Ancona, Italy. Electronic address: claudia.passamonti@unibo.it.
authors.forename: Claudia
authors.initials: C
authors.lastname: Passamonti
authors.affiliation: Department of Pediatric Neurology, Ospedali Riuniti, Ancona, Italy.
authors.forename: Cristina
authors.initials: C
authors.lastname: Petrelli
authors.affiliation: Department of Child Neurology and Psychiatry, Istituto Neurologico C. Mondino, Pavia, Italy.
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Veggiotti
authors.affiliation: Department of Child Neurology and Psychiatry, Istituto Neurologico C. Mondino, Pavia, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Baldassari
authors.affiliation: Department of Pediatrics, University of Perugia, Perugia, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Verrotti
authors.affiliation: Epilepsy Center, Department of Child Neuropsychiatry, C. Poma Hospital, Mantova, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Capovilla
authors.affiliation: Department of Child Neuropsychiatry and Neurophysiology, Fatebenefratelli e Oftalmico Hospital, Milano, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Viri
authors.affiliation: Clinic of Child Neuropsychiatry, University of Salerno, Salerno, Italy.
authors.forename: Giangennaro
authors.initials: G
authors.lastname: Coppola
authors.affiliation: Regional Epilepsy Center, San Paolo Hospital, Milano, Italy.
authors.forename: Aglaia
authors.initials: A
authors.lastname: Vignoli
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000453:epidemiology / Q000235:genetics; D004831:Epilepsies, Myoclonic / Q000453:epidemiology / Q000235:genetics; D004829:Epilepsy, Generalized / Q000453:epidemiology / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D009154:Mutation; D062550:NAV1.1 Voltage-Gated Sodium Channel / Q000235:genetics*; D012640:Seizures / Q000453:epidemiology* / Q000235:genetics*; D003294:Seizures, Febrile / Q000453:epidemiology / Q000235:genetics; D013226:Status Epilepticus / Q000453:epidemiology / Q000235:genetics; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D062550:NAV1.1 Voltage-Gated Sodium Channel; C568242:SCN1A protein, human
keywords: Dravet syndrome; GEFS+; SCN1A gene; cognition; seizure; vaccination