title: Antioxidant, lipid peroxidation inhibition and free radical scavenging efficacy of a diterpenoid compound sugiol isolated from Metasequoia glyptostroboides.
abstract: OBJECTIVE
  To investigate the antioxidant efficacy of a biologically active diterpenoid compound sugiol isolated from Metasequoia glyptostroboides (M. glyptostroboides) in various antioxidant models.
  
  
  METHODS
  An abietane type diterpenoid sugiol, isolated from ethyl acetate extract of M. glyptostroboides cones, was analyzed for its antioxidant efficacy as reducing power ability and lipid peroxidation inhibition as well as its ability to scavenge free radicals such as 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl radicals.
  
  
  RESULTS
  The sugiol showed significant and concentration-dependent antioxidant and free radical scavenging activities. Consequently, the sugiol exerted lipid peroxidation inhibitory effect by 76.5% as compared to α-tocopherol (80.13%) and butylated hydroxyanisole (76.59%). In addition, the sugiol had significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals in a concentration-dependent manner by 78.83%, 72.42%, 72.99% and 85.04%, when compared to the standard compound ascorbic acid (81.69%, 74.62%, 73.00% and 73.79%) and α-tocopherol/butylated hydroxyanisole (84.09%, 78.61%, 74.45% and 70.02%), respectively.
  
  
  CONCLUSIONS
  These findings justify the biological and traditional uses of M. glyptostroboides or its secondary metabolites as confirmed by its promising antioxidant efficacy.
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbook 712-749, Republic of Korea.
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Bajpai
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbook 712-749, Republic of Korea.
authors.forename: Ajay
authors.initials: A
authors.lastname: Sharma
authors.affiliation: Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbook 712-714, Republic of Korea. Electronic address: sckang@daegu.ac.kr.
authors.forename: Sun Chul
authors.initials: SC
authors.lastname: Kang
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbook 712-749, Republic of Korea. Electronic address: khbaek@ynu.ac.kr.
authors.forename: Kwang-Hyun
authors.initials: KH
authors.lastname: Baek
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000032:analysis / Q000378:metabolism; D001923:Brain Chemistry; D002417:Cattle; D029779:Cupressaceae / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers; D015227:Lipid Peroxidation / Q000187:drug effects*; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism; D010851:Picrates / Q000032:analysis / Q000378:metabolism; D012639:Seeds / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004224:Diterpenes; D016166:Free Radical Scavengers; D010743:Phospholipids; D010851:Picrates; C501333:sugiol; C004931:1,1-diphenyl-2-picrylhydrazyl
keywords: Antioxidant; Diterpenoid; Free radicals; Lipid peroxidation; Metasequoia glyptostroboides; Sugiol