title: Switching invariant natural killer T (iNKT) cell response from anticancerous to anti-inflammatory effect: molecular bases.
abstract: Since the discovery in 1995 of α-galactosylceramide 1 (α-GalCer), also known as KRN7000,1 hundreds of compounds have been synthesized in order to activate invariant natural killer T (iNKT) cells. Such keen interest for this lymphocyte cell type is due to its ability to produce different cytokines that bias the immune response toward a Th1 or Th2 profile. Thus, an understanding of the immune polarization mechanism via iNKT activation may pave the way toward new therapeutics in various domains including cancer and infectious and autoimmune diseases. In this review, we propose an up-to-date analysis of iNKT activators associated with a structure-activity relationship (SAR) study aimed at complementing available reviews by highlighting molecular bases for a selective immune response.
authors.affiliation: Faculté de Médecine, Intestinal Biotech Development, Amphis J et K, Boulevard du Professeur Jules Leclerc, 59045 Lille Cedex, France.
authors.forename: Xavier
authors.initials: X
authors.lastname: Laurent
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bertin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Renault
authors.forename: Amaury
authors.initials: A
authors.lastname: Farce
authors.forename: Silvia
authors.initials: S
authors.lastname: Speca
authors.forename: Ophélie
authors.initials: O
authors.lastname: Milhomme
authors.forename: Régis
authors.initials: R
authors.lastname: Millet
authors.forename: Pierre
authors.initials: P
authors.lastname: Desreumaux
authors.forename: Eric
authors.initials: E
authors.lastname: Hénon
authors.forename: Philippe
authors.initials: P
authors.lastname: Chavatte
mesh_terms: D000818:Animals; D055610:Antigens, CD1d / Q000276:immunology; D005699:Galactosylceramides / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008958:Models, Molecular; D055611:Natural Killer T-Cells / Q000187:drug effects / Q000276:immunology*; D051381:Rats; D013329:Structure-Activity Relationship; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D055610:Antigens, CD1d; C526877:CD1D protein, human; D005699:Galactosylceramides; D008024:Ligands; C493154:alpha-galactosylceramide; C103873:KRN 7000