title: Engineering the heart: evaluation of conductive nanomaterials for improving implant integration and cardiac function.
abstract: Recently, carbon nanotubes together with other types of conductive materials have been used to enhance the viability and function of cardiomyocytes in vitro. Here we demonstrated a paradigm to construct ECTs for cardiac repair using conductive nanomaterials. Single walled carbon nanotubes (SWNTs) were incorporated into gelatin hydrogel scaffolds to construct three-dimensional ECTs. We found that SWNTs could provide cellular microenvironment in vitro favorable for cardiac contraction and the expression of electrochemical associated proteins. Upon implantation into the infarct hearts in rats, ECTs structurally integrated with the host myocardium, with different types of cells observed to mutually invade into implants and host tissues. The functional measurements showed that SWNTs were essential to improve the performance of ECTs in inhibiting pathological deterioration of myocardium. This work suggested that conductive nanomaterials hold therapeutic potential in engineering cardiac tissues to repair myocardial infarction.
authors.affiliation: 1] Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China [2].
authors.forename: Jin
authors.initials: J
authors.lastname: Zhou
authors.affiliation: 1] Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba and Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada [2].
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.affiliation: 1] Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China [2].
authors.forename: Hongyu
authors.initials: H
authors.lastname: Sun
authors.affiliation: 1] Department of Anatomy, Southern Medical University, Guangzhou Guangdong, China [2].
authors.forename: Xiaozhong
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Mou
authors.affiliation: Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Cuimi
authors.initials: C
authors.lastname: Duan
authors.affiliation: Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Rongyu
authors.initials: R
authors.lastname: Tang
authors.affiliation: Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Chunlan
authors.initials: C
authors.lastname: Wang
authors.affiliation: Department of Textile Sciences, Faculty of Human Ecology, Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Canada.
authors.forename: Wen
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Department of Biomedical Engineering, College of Engineering, 5 Yiheyuan Rd, Peking University, HaidianDist, Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Biomedical Engineering, College of Engineering, 5 Yiheyuan Rd, Peking University, HaidianDist, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Luo
authors.affiliation: Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Department of Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba and Manitoba Institute of Child Health, Winnipeg, Manitoba, Canada.
authors.forename: Malcolm
authors.initials: M
authors.lastname: Mengqiu Xing
authors.affiliation: Department of Advanced Interdisciplinary Studies, Institute of Basic Medical Sciences and Tissue Engineering Research Center, 27 Taiping Rd, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Changyong
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D004195:Disease Models, Animal; D005780:Gelatin; D006321:Heart / Q000502:physiology*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008297:Male; D008422:Materials Testing; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy; D009206:Myocardium / Q000378:metabolism; D049329:Nanostructures / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry; D019736:Prostheses and Implants; D051381:Rats; D023822:Tissue Engineering; D054457:Tissue Scaffolds; D016277:Ventricular Function, Left
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D005780:Gelatin