title: The solute carrier family 1 (glial high affinity glutamate transporter), member 2 gene, SLC1A2, rs3794087 variant and assessment risk for restless legs syndrome.
abstract: OBJECTIVE
  A glutamatergic dysfunction has been postulated to play a role in restless legs syndrome (RLS) pathophysiology, as glutamate concentrations have been found to increase in the thalamus of RLS patients. The aim of our study was to investigate the possible association between the single nucleotide polymorphism (SNP) rs3794087 in the solute carrier family 1 (glial high affinity glutamate transporter), member 2 gene, SLC1A2, related with glutamate transport and the risk for RLS.
  
  
  METHODS
  We studied the allelic and genotype frequencies of the SNP rs3794087 in 205 patients with RLS and 328 healthy controls using TaqMan genotyping.
  
  
  RESULTS
  The rs3794087 genotype and allelic frequencies did not significantly differ between patients with RLS and controls and were unrelated with the age at onset of RLS, gender, and family history of RLS.
  
  
  CONCLUSIONS
  The results of our study suggest that the rs3794087 polymorphism is not related to the risk for RLS.
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain; Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain. Electronic address: fjavier.jimenez@salud.madrid.org.
authors.forename: Félix Javier
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain; Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Hortensia
authors.initials: H
authors.lastname: Alonso-Navarro
authors.affiliation: Department of Pharmacology, University of Extremadura, Badajoz, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez
authors.affiliation: Section of Neurology, Hospital Virgen del Puerto, Plasencia, Cáceres, Spain.
authors.forename: Martín
authors.initials: M
authors.lastname: Zurdo
authors.affiliation: Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Turpín-Fenoll
authors.affiliation: Section of Neurology, Hospital La Mancha-Centro, Alcázar de San Juan, Ciudad Real, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Millán-Pascual
authors.affiliation: Unit of Neurology, Clínica Recoletas, Zamora, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Adeva-Bartolomé
authors.affiliation: Section of Neurology, Hospital Universitario de Burgos, Burgos, Spain.
authors.forename: Esther
authors.initials: E
authors.lastname: Cubo
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Navacerrada
authors.affiliation: Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Rojo-Sebastián
authors.affiliation: Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
authors.forename: Lluisa
authors.initials: L
authors.lastname: Rubio
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain.
authors.forename: Marisol
authors.initials: M
authors.lastname: Calleja
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain.
authors.forename: José Francisco
authors.initials: JF
authors.lastname: Plaza-Nieto
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain.
authors.forename: Belén
authors.initials: B
authors.lastname: Pilo-de-la-Fuente
authors.affiliation: Section of Neurology, Hospital Universitario del Sureste, Arganda del Rey, Madrid, Spain.
authors.forename: Margarita
authors.initials: M
authors.lastname: Arroyo-Solera
authors.affiliation: Department of Biochemistry and Molecular Biology, Universidad de Extremadura, Cáceres, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: García-Martín
authors.affiliation: Department of Pharmacology, University of Extremadura, Cáceres, Spain.
authors.forename: José A G
authors.initials: JA
authors.lastname: Agúndez
mesh_terms: D000328:Adult; D000483:Alleles; D027342:Excitatory Amino Acid Transporter 2; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D050491:Glutamate Plasma Membrane Transport Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012148:Restless Legs Syndrome / Q000235:genetics*; D012307:Risk Factors
chemical_list: D027342:Excitatory Amino Acid Transporter 2; D050491:Glutamate Plasma Membrane Transport Proteins; C493397:SLC1A2 protein, human
keywords: Excitotoxicity; Genetics; Glutamate; Polymorphisms; Restless legs syndrome; Risk factors; SLC1A2 gene