title: Transgenic rice endosperm as a bioreactor for molecular pharming.
abstract: Plants provide a promising expression platform for producing recombinant proteins with several advantages in terms of high expression level, lower production cost, scalability, and safety and environment-friendly. Molecular pharming has been recognized as an emerging industry with strategic importance that could play an important role in economic development and healthcare in China. Here, this review represents the significant advances using transgenic rice endosperm as bioreactor to produce various therapeutic recombinant proteins in transgenic rice endosperm and large-scale production of OsrHSA, and discusses the challenges to develop molecular pharming as an emerging industry with strategic importance in China.
authors.affiliation: College of Life Sciences, State Key Laboratory of Hybrid Rice, Wuhan University, Wuhan, China.
authors.forename: Jiquan
authors.initials: J
authors.lastname: Ou
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Guo
authors.forename: Jingni
authors.initials: J
authors.lastname: Shi
authors.forename: Xianghong
authors.initials: X
authors.lastname: Wang
authors.forename: Jingru
authors.initials: J
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Shi
authors.forename: Fengli
authors.initials: F
authors.lastname: Guo
authors.forename: Chufu
authors.initials: C
authors.lastname: Zhang
authors.forename: Daichnag
authors.initials: D
authors.lastname: Yang
mesh_terms: D019149:Bioreactors; D056625:Endosperm / Q000235:genetics*; D058634:Molecular Farming / Q000379:methods*; D012275:Oryza / Q000235:genetics*; D030821:Plants, Genetically Modified; D011994:Recombinant Proteins / Q000378:metabolism
chemical_list: D011994:Recombinant Proteins