title: Surgical outcomes and prognostic factors in elderly patients (75 years or older) with hepatocellular carcinoma who underwent hepatectomy.
abstract: BACKGROUND
  Whether hepatic resection is indicated for elderly patients with hepatocellular carcinoma (HCC) remains controversial.
  
  
  METHODS
  This retrospective study evaluated surgical outcomes and prognostic factors in elderly patients with HCC who underwent hepatectomy. Overall survival rates and disease-free survival rates after hepatectomy were compared between 63 patients with HCC who were 75 years or older (elderly group) and 353 patients with HCC who were younger than 75 years (younger group). Prognostic factors in the elderly group were evaluated by means of multivariate analysis with a Cox's proportional-hazards model.
  
  
  RESULTS
  Overall survival rates at 3 and 5 years were respectively 56.2% and 40.2% in the elderly group and 63.4% and 46.6% in the younger group. Disease-free survival rates at these times were 34.9% and 34.9% in the elderly group and 30.8% and 21.5% in the younger group. These differences were not significant. Multivariate analysis revealed a significant association between Child-Pugh class and outcomes (P=0.01).
  
  
  CONCLUSIONS
  The safety and survival benefits of hepatectomy in carefully selected elderly patients with HCC are similar to those in younger patients.
authors.affiliation: Department of Surgery, Nippon Medical School.
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Taniai
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshida
authors.forename: Masato
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kawano
authors.forename: Eiji
authors.initials: E
authors.lastname: Uchida
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery*; D008297:Male; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000209:etiology; D011379:Prognosis; D016896:Treatment Outcome