title: Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population.
abstract: This case-control study focused on estimating the association between miR-146a polymorphism and risk of nasopharyngeal carcinoma (NPC) in central-south China. In total, 160 patients with NPC and 200 healthy controls in central-south China were genotyped using polymerase chain reaction-restriction fragment length polymorphism assay. Chi-square test was used to assess the different distribution of miR-146a polymorphism between NPC patients and controls; and logistic regression analysis was applied to analyze the associations between miR-146a polymorphism with cancer risk in different contrast models. Significant differences between NPC patients and controls were found in genotype (P=0.033 for GG versus CG versus CC; and odds ratio (OR)=0.568, 95% confidence interval (CI)=0.354-0.912, P=0.019 for CG versus CC; and OR=0.503, 95% CI=0.261-0.971, P=0.041 for CG versus CC; and OR=0.564, 95% CI=0.360-0.884, P=0.012 for GG+CG versus CC, respectively) and allelic analysis (P=0.025 for G versus C). Our findings suggested that polymorphism of mir-146a was associated with NPC in the central-southern Chinese population.
authors.affiliation: 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Huang
authors.affiliation: Institute Of Laboratory Medicine, Guangdong Medical College, Dongguan, China.
authors.forename: Mei-Ling
authors.initials: ML
authors.lastname: Chen
authors.affiliation: Institute Of Laboratory Medicine, Guangdong Medical College, Dongguan, China.
authors.forename: Ya-Zhen
authors.initials: YZ
authors.lastname: Li
authors.affiliation: 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.affiliation: Department of Medical Oncology, Hunan Tumor Hospital, Changsha, China.
authors.forename: Xing-Xiang
authors.initials: XX
authors.lastname: Pu
authors.affiliation: Department of Oncology, Central South University Xiangya Hospital, Changsha, China.
authors.forename: Yu-Xiang
authors.initials: YX
authors.lastname: He
authors.affiliation: Institute Of Laboratory Medicine, Guangdong Medical College, Dongguan, China.
authors.forename: Shu-Yin
authors.initials: SY
authors.lastname: Tang
authors.affiliation: Institute Of Laboratory Medicine, Guangdong Medical College, Dongguan, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Che
authors.affiliation: 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zou
authors.affiliation: 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Congcong
authors.initials: C
authors.lastname: Ding
authors.affiliation: 1] Sino-American Cancer Research Institute, Guangdong Medical College, Dongguan, China [2] Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Dongguan, China.
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: He
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D002277:Carcinoma; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs