title: Amino acid-linked platinum(II) analogues have altered specificity for RNA compared to cisplatin.
abstract: Cisplatin can be modified with various ligands to alter the size and charge distribution of the complex. Several amino acid-linked platinum(II) complexes were synthesized, and a reactivity study with 16S ribosomal RNA was carried out. The amino acid-linked analogues show altered specificity compared to the parental compound cisplatin.
authors.affiliation: Department of Chemistry, Wayne State University, 5101 Cass Ave., Detroit, MI 48202, USA. cchow@wayne.edu.
authors.forename: Keshab
authors.initials: K
authors.lastname: Rijal
authors.forename: Xun
authors.initials: X
authors.lastname: Bao
authors.forename: Christine S
authors.initials: CS
authors.lastname: Chow
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002945:Cisplatin / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D009942:Organometallic Compounds; D010984:Platinum; D012313:RNA; D002945:Cisplatin