title: The Diagnostic Efficiency of 99mTc-EDDA/HYNIC-Octreotate SPECT-CT in Comparison with 111In-Pentetrotide in the Detection of Neuroendocrine Tumours.
abstract: OBJECTIVE
  The aim of this study was to assess the diagnostic efficiency of (99m)Tc-EDDA/HYNIC-Octreotate in comparison with (111)Inpentetrotide scintigraphy in the detection of neuroendocrine tumors. This study also evaluates the impact of SPECT-CT hybrid imaging on somatostatin receptor scintigraphy (SRS) interpretation and clinical management of these tumors.
  
  
  METHODS
  Fourteen patients were included in the study. All patients underwent a whole body and SPECT-CT imaging with both (99m)Tc- EDDA/HYNIC-octreotate and (111)In-pentetrotide. Images were evaluated both visually and semiquantitatively.
  
  
  RESULTS
  On patient basis, the diagnostic results of both studies were similar. The number of lesions detected by (99m)Tc- EDDA/HYNICOctreotate were higher than the number of lesions detected by (111)In-pentetrotide however the difference was not significant (40/43( 93%), 36/43 (83%) p=0.109). Semiquantitative analysis showed higher tumor/organ count ratios for both whole-body and SPECT (99m)Tc- EDDA/HYNIC-Octreotate scans.
  
  
  CONCLUSIONS
  The results of this study suggested that, (99m)Tc- EDDA/HYNIC-Octreotate may be a better alternative to (111)In- pentetrotide due to high image quality and lower radiation dose. SPECT/CT is a valuable tool for the assessment of neuroendocrine tumors by providing the precise anatomic localization of scintigraphic findings thus improving lesion detectability and characterization.
  
  
  BACKGROUND
  None declared.
authors.affiliation: Department of Nuclear Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Emel
authors.initials: E
authors.lastname: Koçyiğit Deveci
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Ocak
authors.affiliation: Department of Nuclear Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Murat Fani
authors.initials: MF
authors.lastname: Bozkurt
authors.affiliation: Department of Radiopharmacy, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
authors.forename: Selcan
authors.initials: S
authors.lastname: Türker
authors.affiliation: Department of Nuclear Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Levent
authors.initials: L
authors.lastname: Kabasakal
authors.affiliation: Department of Nuclear Medicine, Hacettepe University, Ankara, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Uğur
keywords: Computeized Tomography; Single–Photon Emission Computerized Tomography; Somatostatin receptors; X ray; neuroendocrine tumors