title: The response to inositol: regulation of glycerolipid metabolism and stress response signaling in yeast.
abstract: This article focuses on discoveries of the mechanisms governing the regulation of glycerolipid metabolism and stress response signaling in response to the phospholipid precursor, inositol. The regulation of glycerolipid lipid metabolism in yeast in response to inositol is highly complex, but increasingly well understood, and the roles of individual lipids in stress response are also increasingly well characterized. Discoveries that have emerged over several decades of genetic, molecular and biochemical analyses of metabolic, regulatory and signaling responses of yeast cells, both mutant and wild type, to the availability of the phospholipid precursor, inositol are discussed.
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA. Electronic address: sah42@cornell.edu.
authors.forename: Susan A
authors.initials: SA
authors.lastname: Henry
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Maria L
authors.initials: ML
authors.lastname: Gaspar
authors.affiliation: Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Jesch
mesh_terms: D005990:Glycerol / Q000378:metabolism*; D006801:Humans; D007294:Inositol / Q000096:biosynthesis / Q000378:metabolism*; D050356:Lipid Metabolism; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D013312:Stress, Physiological
chemical_list: D007294:Inositol; D005990:Glycerol
keywords: Glycerolipids; Inositol; Phosphatidic acid; Phosphatidylinositol; Sphingolipids; Stress response