title: Hyperandrogenemia is implicated in both the metabolic and reproductive morbidities of polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine the features of polycystic ovary syndrome (PCOS) that are implicated in the associated reproductive and metabolic morbidities.
  
  
  METHODS
  Cross-sectional case-control study.
  
  
  METHODS
  Academic medical setting.
  
  
  METHODS
  A total of 1,062 women with PCOS and 1,887 women without PCOS.
  
  
  METHODS
  None.
  
  
  METHODS
  Physical examination including hirsutism scoring, biochemical and hormone measurements, ovarian ultrasound, and a 75-g oral glucose tolerance test to measure glucose and insulin levels.
  
  
  RESULTS
  A factor analysis identified four dominant factors in women with PCOS. These factors were interpreted as follows: [1] metabolic and hyperandrogenemia factor, [2] oligomenorrhea and hyperandrogenemia factor, [3] blood pressure factor, and [4] ovarian morphology factor. In women with PCOS, hyperandrogenemia was a significant predictor of metabolic syndrome after adjusting for age, body mass index, and insulin resistance in the regression analysis.
  
  
  CONCLUSIONS
  A factor analysis identified multiple factors that are responsible for the abnormalities associated with PCOS. Hyperandrogenemia was a common underlying feature of the metabolic and reproductive abnormalities in women with PCOS but not in women without PCOS.
authors.affiliation: Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea.
authors.forename: Yeon-Ah
authors.initials: YA
authors.lastname: Sung
authors.affiliation: Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea.
authors.forename: Jee-Young
authors.initials: JY
authors.lastname: Oh
authors.affiliation: Department of Obstetrics and Gynecology, Ewha Womans University School of Medicine, Seoul, South Korea.
authors.forename: Hyewon
authors.initials: H
authors.lastname: Chung
authors.affiliation: Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, South Korea. Electronic address: hyejinlee@ewha.ac.kr.
authors.forename: Hyejin
authors.initials: H
authors.lastname: Lee
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D012098:Reproduction / Q000502:physiology*; D055815:Young Adult
chemical_list: D001786:Blood Glucose
keywords: Hyperandrogenemia; metabolic morbidity; polycystic ovary syndrome; reproductive morbidity