title: Circadian clocks: the tissue is the issue.
abstract: The circadian clock uses a widely expressed pair of clock activators to drive tissue-specific rhythms in target gene expression. A new study sheds light on this tissue specificity by showing that binding of clock activators and tissue-specific transcription factors to closely associated target sites enables cooperative activation of target genes in different tissues.
authors.affiliation: Department of Biology and Center for Biological Clocks Research, Texas A&M University, College Station, TX 77843-3258, USA.
authors.forename: Jerome S
authors.initials: JS
authors.lastname: Menet
authors.affiliation: Department of Biology and Center for Biological Clocks Research, Texas A&M University, College Station, TX 77843-3258, USA. Electronic address: phardin@bio.tamu.edu.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Hardin
mesh_terms: D056930:ARNTL Transcription Factors / Q000378:metabolism*; D000818:Animals; D056926:CLOCK Proteins / Q000378:metabolism*; D057906:Circadian Clocks; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*
chemical_list: D056930:ARNTL Transcription Factors; D029721:Drosophila Proteins; C112805:cyc protein, Drosophila; D056926:CLOCK Proteins