title: Inhibition of aflatoxin production inAspergillus flavus by natural coumarins and chromones.
abstract: The activities of three natural coumarins, xanthotoxin and bergapten (fromAmmi majus, Umbelliferae) and psoralene (fromFicus cycomorus, Moraceae), were tested against mycelial growth and aflatoxin production of a toxigenic strain ofAspergillus flavus grown in a rice/corn steep liquor medium. Two other natural chromones, khellin and visnagin (fromAmmi visnaga) were also compared. Complete inhibition of aflatoxin release occurred with either xanthotoxin or khellin at 5 mM. The other three compounds also at 5 mM reduced aflatoxin to 12 to 16% of its original concentration. The mould growth was only slightly inhibited by all the compounds used.
authors.affiliation: Department of Chemistry of Natural and Microbial Products, National Research Centre, Dokki, Cairo, Egypt.
authors.forename: S S
authors.initials: SS
authors.lastname: Mabrouk
authors.forename: N M
authors.initials: NM
authors.lastname: El-Shayeb