title: The cyclin-like protein Spy1 regulates growth and division characteristics of the CD133+ population in human glioma.
abstract: The heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and treatment. Identifying and targeting populations of cells driving tumorigenesis is a top priority for the cancer biology field. This is not a trivial task; considerable variance exists in the driving mutations, identifying markers, and evolutionary pressures influencing initiating cells in different individual tumors. Despite this, the ability to self-renew and differentiate must be conserved to reseed a heterogeneous tumor mass. Focusing on one example of a tumor-initiating cell population, we demonstrate that the atypical cyclin-like protein Spy1 plays a role in balancing the division properties of glioma cells with stemness properties. This mechanistic insight may provide new opportunities for therapeutic intervention of brain cancer.
authors.affiliation: Department of Biological Sciences, University of Windsor Ontario, Windsor, ON N9B 3P4, Canada.
authors.forename: Dorota
authors.initials: D
authors.lastname: Lubanska
authors.affiliation: Department of Biological Sciences, University of Windsor Ontario, Windsor, ON N9B 3P4, Canada.
authors.forename: Brenna A
authors.initials: BA
authors.lastname: Market-Velker
authors.affiliation: Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Ana C
authors.initials: AC
authors.lastname: deCarvalho
authors.affiliation: Department of Neurosurgery, Henry Ford Hospital, Detroit, MI 48202, USA.
authors.forename: Tom
authors.initials: T
authors.lastname: Mikkelsen
authors.affiliation: Department of Biological Sciences, University of Windsor Ontario, Windsor, ON N9B 3P4, Canada.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fidalgo da Silva
authors.affiliation: Department of Biological Sciences, University of Windsor Ontario, Windsor, ON N9B 3P4, Canada. Electronic address: lporter@uwindsor.ca.
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Porter
mesh_terms: D000071916:AC133 Antigen; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002455:Cell Division; D005910:Glioma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D042282:Microdissection; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D058953:Neural Stem Cells / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D011379:Prognosis; D046888:Tissue Array Analysis
chemical_list: D000071916:AC133 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D006023:Glycoproteins; C000606023:PROM1 protein, human; D010455:Peptides; C000606024:Prom1 protein, mouse; C486530:SPDYA protein, human