title: Pharmacokinetics of daily versus monthly vitamin D3 supplementation in non-lactating women.
abstract: This study compared serum cholecalciferol and 25-hydroxyvitamin D (25(OH)D) concentrations over four weeks in healthy, non-pregnant, non-lactating females aged 18-40 years, who were randomized to oral cholecalciferol 5000 international units (IU) daily for 28 days or a single dose of 150 000 IU. The study was conducted in Rochester, MN in March and April of 2010. We found no difference in mean 25(OH)D between treatment groups on study day 0 or day 28 (P=0.14 and 0.28, respectively). The daily group had 11 more days of detectable serum cholecalciferol than the single-dose group (P<0.001). There was no difference observed in cholecalciferol area under the curve (AUC28) between groups (P=0.49). However, the single-dose group had a significantly greater mean 25(OH)D AUC28 compared with the daily group (P<0.001).
authors.affiliation: Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Meekins
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Oberhelman
authors.affiliation: Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Lee
authors.affiliation: Department of Pharmacy, Mayo Clinic, Rochester, MN, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Gardner
authors.affiliation: Department of Biostatistics and Informatics, Mayo Clinic, Rochester, MN, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Cha
authors.affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Singh
authors.affiliation: Developmental Pathways for Health Research Unit, Department of Paediatrics, University of Witwatersrand, Johannesburg, South Africa.
authors.forename: J M
authors.initials: JM
authors.lastname: Pettifor
authors.affiliation: Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Fischer
authors.affiliation: Department of Family Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: T D
authors.initials: TD
authors.lastname: Thacher
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D002762:Cholecalciferol / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007774:Lactation; D055815:Young Adult
chemical_list: D002762:Cholecalciferol