title: A Crowdsourced nucleus: understanding nuclear organization in terms of dynamically networked protein function.
abstract: The spatial organization of the nucleus results in a compartmentalized structure that affects all aspects of nuclear function. This compartmentalization involves genome organization as well as the formation of nuclear bodies and plays a role in many functions, including gene regulation, genome stability, replication, and RNA processing. Here we review the recent findings associated with the spatial organization of the nucleus and reveal that a common theme for nuclear proteins is their ability to participate in a variety of functions and pathways. We consider this multiplicity of function in terms of Crowdsourcing, a recent phenomenon in the world of information technology, and suggest that this model provides a novel way to synthesize the many intersections between nuclear organization and function. This article is part of a Special Issue entitled: Chromatin and epigenetic regulation of animal development.
authors.affiliation: Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Wood
authors.affiliation: Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Arturo G
authors.initials: AG
authors.lastname: Garza-Gongora
authors.affiliation: Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: s-kosak@northwestern.edu.
authors.forename: Steven T
authors.initials: ST
authors.lastname: Kosak
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D042822:Genomic Instability / Q000502:physiology*; D006801:Humans; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology*
keywords: Genome organization; Nuclear body; Nuclear organization