title: Adoptive immunotherapy for cancer or viruses.
abstract: Adoptive immunotherapy, or the infusion of lymphocytes, is a promising approach for the treatment of cancer and certain chronic viral infections. The application of the principles of synthetic biology to enhance T cell function has resulted in substantial increases in clinical efficacy. The primary challenge to the field is to identify tumor-specific targets to avoid off-tumor, on-target toxicity. Given recent advances in efficacy in numerous pilot trials, the next steps in clinical development will require multicenter trials to establish adoptive immunotherapy as a mainstream technology.
authors.affiliation: Translational Research Program, Abramson Cancer Center and.
authors.forename: Marcela V
authors.initials: MV
authors.lastname: Maus
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Fraietta
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Levine
authors.forename: Michael
authors.initials: M
authors.lastname: Kalos
authors.forename: Yangbing
authors.initials: Y
authors.lastname: Zhao
authors.forename: Carl H
authors.initials: CH
authors.lastname: June
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D000941:Antigens / Q000235:genetics / Q000276:immunology; D015415:Biomarkers; D064987:Cell- and Tissue-Based Therapy; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D016219:Immunotherapy, Adoptive; D009369:Neoplasms / Q000235:genetics / Q000276:immunology* / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D037182:T-Cell Antigen Receptor Specificity / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D014161:Transduction, Genetic; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology* / Q000628:therapy*
chemical_list: D000941:Antigens; D015415:Biomarkers; D011948:Receptors, Antigen, T-Cell