title: Homologous Canavalia lectins elicit different patterns of antinociceptive responses.
abstract: Canavalia gladiata (CGL), C. maritima (ConM) and C. brasiliensis (ConBr) lectins were evaluated in nociception models. ConBr inhibited first (32%) and second (100%) phases of the formalin test; CGL inhibited only the first (74%) and ConM only the second (59%) phase. Hypernociception evaluated in the Von Frey test was inhibited by ConM (55%), CGL (41%) and ConBr (38%). Acetic acid-induced abdominal writhing was reduced by ConBr (66%), CGL (52%) and ConM (60%). ConBr and CGL effects were reversed by the lectin association with its ligand sugar. The antinociceptive activity of the structural homologous lectins was differentiated by potency, efficacy and mechanisms.
authors.affiliation: Instituto Superior de Ciências Biomédicas, Universidade Estadual do Cearcá, Av. Paranjana 1700, 60.740-000, Fortaleza-CE-Brasil.
authors.forename: Nilson Vieira
authors.initials: NV
authors.lastname: Pinto
authors.affiliation: Instituto Superior de Ciências Biomédicas, Universidade Estadual do Cearcá, Av. Paranjana 1700, 60.740-000, Fortaleza-CE-Brasil.
authors.forename: Cláudia Ferreira
authors.initials: CF
authors.lastname: Santos
authors.affiliation: Departamento de Bioquimíca e Biologia Molecular, Universidade Federal do Ceará, Av. Mister Hull s/n Bloco 907, 60.445-970, Fortaleza-CE-Brasil.
authors.forename: Benildo Sousa
authors.initials: BS
authors.lastname: Cavada
authors.affiliation: Departamento de Bioquimíca e Biologia Molecular, Universidade Federal do Ceará, Av. Mister Hull s/n Bloco 907, 60.445-970, Fortaleza-CE-Brasil.
authors.forename: Kyria Santiago
authors.initials: KS
authors.lastname: do Nascimento
authors.affiliation: Departamento de Bioquimíca e Biologia Molecular, Universidade Federal do Ceará, Av. Mister Hull s/n Bloco 907, 60.445-970, Fortaleza-CE-Brasil.
authors.forename: Francisco Nascimento
authors.initials: FN
authors.lastname: Pereira Junior
authors.affiliation: Instituto Superior de Ciências Biomédicas, Universidade Estadual do Cearcá, Av. Paranjana 1700, 60.740-000, Fortaleza-CE-Brasil.
authors.forename: Alana de Freitas
authors.initials: Ade F
authors.lastname: Pires
authors.affiliation: Instituto Superior de Ciências Biomédicas, Universidade Estadual do Cearcá, Av. Paranjana 1700, 60.740-000, Fortaleza-CE-Brasil.
authors.forename: Ana Maria Sampaio
authors.initials: AM
authors.lastname: Assreuy
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D037121:Plant Lectins / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D037121:Plant Lectins; C039268:lectin, Canavalia