title: Hürthle cells in fine-needle aspirates of the thyroid: a review of their diagnostic criteria and significance.
abstract: Although the cytological assessment of Hürthle cell lesions is challenging, the literature offers good, albeit imperfect, guidance to aid in the crucial distinction between nonneoplastic and neoplastic lesions. The significance of a cytologic diagnosis of follicular neoplasm, Hürthle cell type, lies in the rate of malignancy on follow-up surgical excision, ranging in the literature from 10% to 45%. A cytodiagnosis of atypia of undetermined significance (AUS), Hürthle cell type, appears to be associated with a lower risk of malignancy on follow-up than other subtypes of AUS; however, this area warrants further investigation.
authors.affiliation: Department of Pathology, McGill University and McGill University Health Center, Montreal, PQ, Canada.
authors.forename: Manon
authors.initials: M
authors.lastname: Auger
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology* / Q000601:surgery; D044963:Biopsy, Fine-Needle; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020380:Needs Assessment; D024862:Oxyphil Cells / Q000473:pathology*; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013959:Thyroid Diseases / Q000473:pathology / Q000601:surgery; D013961:Thyroid Gland / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery
keywords: Hürthle cells; cytology; fine-needle aspirate; oncocytes; thyroid