title: T cell ageing: effects of age on development, survival & function.
abstract: Age associated decline of the immune system continues to be a major health concern. All components of innate and adaptive immunity are adversely affected to lesser or greater extent by ageing resulting in an overall decline of immunocompetence. As a result in the aged population, there is increased susceptibility to infection, poor responses to vaccination, and increased incidence of autoreactivity. There is an increasing focus on the role of T cells during ageing because of their impact on the overall immune responses. A steady decline in the production of fresh naïve T cells, more restricted T cell receptor (TCR) repertoire and weak activation of T cells are some of the effects of ageing. In this review we summarize our present understanding of the effects of ageing on naïve CD4 T cells and potential approaches for therapeutic interventions to restore protective immunity in the aged population.
authors.affiliation: National Institute of Immunology, New Delhi, India.
authors.forename: Nasir
authors.initials: N
authors.lastname: Salam
authors.forename: Sanket
authors.initials: S
authors.lastname: Rane
authors.forename: Rituparna
authors.initials: R
authors.lastname: Das
authors.forename: Matthew
authors.initials: M
authors.lastname: Faulkner
authors.forename: Rupali
authors.initials: R
authors.lastname: Gund
authors.forename: Usha
authors.initials: U
authors.lastname: Kandpal
authors.forename: Virginia
authors.initials: V
authors.lastname: Lewis
authors.forename: Hamid
authors.initials: H
authors.lastname: Mattoo
authors.forename: Savit
authors.initials: S
authors.lastname: Prabhu
authors.forename: Vidya
authors.initials: V
authors.lastname: Ranganathan
authors.forename: Jeannine
authors.initials: J
authors.lastname: Durdik
authors.forename: Anna
authors.initials: A
authors.lastname: George
authors.forename: Satyajit
authors.initials: S
authors.lastname: Rath
authors.affiliation: National Institute of Immunology, New Delhi, India.
authors.forename: Vineeta
authors.initials: V
authors.lastname: Bal
mesh_terms: D056704:Adaptive Immunity; D000375:Aging / Q000235:genetics* / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016922:Cellular Senescence / Q000235:genetics / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology
chemical_list: D011948:Receptors, Antigen, T-Cell