title: The prognostic value of P-cadherin in non-muscle-invasive bladder cancer.
abstract: OBJECTIVE
  This research aims to specify the prognostic value of P-cadherin on recurrence and progression in non-muscle-invasive bladder cancers (NMIBC).
  
  
  METHODS
  A total of 110 NMIBC cases were collected and P-cadherin protein was assessed by immunohistochemical test in these samples. Correlations between P-cadherin expression and clinicopathologic features were analyzed. For recurrence-free and progression-free survival, Kaplan-Meier log-rank test was used. Then Cox univariate and multivariate analyses were further performed.
  
  
  RESULTS
  P-cadherin high expression correlated with tumor progression (P = 0.031). Kaplan-Meier results showed that patients with high P-cadherin expression had worse progression-free survival (P = 0.034) but not recurrence-free survival (P = 0.133) than low-expression patients. Cox regression results showed P-cadherin expression was an independent predictor for progression (P = 0.042) but not recurrence (P = 0.139) in NMIBC.
  
  
  CONCLUSIONS
  Our results demonstrated that P-cadherin expression correlated with tumor progression and could be taken as an independent predictor for progression in NMIBC.
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: P
authors.initials: P
authors.lastname: Wang
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: S L
authors.initials: SL
authors.lastname: Lin
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: L H
authors.initials: LH
authors.lastname: Zhang
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Pathology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Clinical Stem Cell Research Center, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: J X
authors.initials: JX
authors.lastname: Gao
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: D M
authors.initials: DM
authors.lastname: Liu
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China. Electronic address: bojuanjie@sina.com.
authors.forename: J J
authors.initials: JJ
authors.lastname: Bo
authors.affiliation: Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: Y R
authors.initials: YR
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D001707:Biopsy, Needle; D015820:Cadherins / Q000032:analysis* / Q000235:genetics; D002295:Carcinoma, Transitional Cell / Q000737:chemistry* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D015331:Cohort Studies; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000235:genetics / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000401:mortality; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D016019:Survival Analysis; D001749:Urinary Bladder Neoplasms / Q000737:chemistry* / Q000235:genetics* / Q000401:mortality / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D005819:Genetic Markers
keywords: Non-muscle-invasive bladder cancer; P-cadherin; Progression; Recurrence