title: Long-term survival of a patient with extensive small cell carcinoma of unknown primary etiology complicated by nephrotic syndrome.
abstract: We experienced a case of nephrotic syndrome (membranous nephropathy) complicated by extensive small cell carcinoma of unknown primary etiology that was diagnosed based on the findings of bilateral cervical and mediastinal lymphadenopathy. A complete cancer response and proteinuria remission following radical chemoradiation therapy were documented. The status of a complete response and nephrosis remission persisted for more than three years. This is the first report to demonstrate the long-term survival of a patient with extensive small cell carcinoma of unknown primary etiology complicated by paraneoplastic nephrotic syndrome.
authors.affiliation: Division of Pulmonary Medicine, St. Luke's International Hospital, Japan.
authors.forename: Genta
authors.initials: G
authors.lastname: Ishikawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Nishimura
authors.forename: Sayaka
authors.initials: S
authors.lastname: Mochizuki
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yamano
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kitamura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tomishima
authors.forename: Torahiko
authors.initials: T
authors.lastname: Jinta
authors.forename: Koyu
authors.initials: K
authors.lastname: Suzuki
authors.forename: Naohiko
authors.initials: N
authors.lastname: Chohnabayashi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D016190:Carboplatin / Q000008:administration & dosage; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004487:Edema / Q000209:etiology; D005047:Etoposide / Q000008:administration & dosage; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D006801:Humans; D000077146:Irinotecan; D008207:Lymphatic Metastasis; D009382:Neoplasms, Unknown Primary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000532:radiotherapy; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000209:etiology*; D016066:Pleural Effusion, Malignant / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology; D011507:Proteinuria / Q000209:etiology; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
chemical_list: D005047:Etoposide; D000077146:Irinotecan; D016190:Carboplatin; D002166:Camptothecin