title: Evaluation of an air spinning process to produce tailored biosynthetic nanofibre scaffolds.
abstract: We optimised the working parameters of an innovative air spinning device to produce nanofibrous polymer scaffolds for tissue engineering applications. Scanning electron microscopy was performed on the fibre scaffolds which were then used to identify various scaffold morphologies based on the ratio of surface occupied by the polymer fibres on that covered by the entire polymer scaffold assembly. Scaffolds were then produced with the spinning experimental parameters, resulting in 90% of fibres in the overall polymer construct, and were subsequently used to perform a multiple linear regression analysis to highlight the relationship between nanofibre diameter and the air spinning parameters. Polymer solution concentration was deemed as the most significant parameter to control fibre diameter during the spinning process, despite interactions between experimental parameters. Based on these findings, viscosity measurements were performed to clarify the effect of the polymer solution property on scaffold morphology.
authors.affiliation: Laboratoire de Physique et Mécanique Textile, École Nationale Supérieure d'Ingénieurs du Sud Alsace, Université de Haute Alsace, 11 rue Alfred Werner, 68093 Mulhouse Cedex, Mulhouse, France; Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de génie des mines, de la métallurgie et des matériaux, Université Laval 1045 avenue de la Médecine, Bureau 1033, Québec, G1V 0A6 Québec, Canada; Centre de recherche du CHU de Québec, Hôpital St François d'Assise, 10 rue de l'Espinay, local E0-165, Québec (QC), G1L 3L5 Québec, Canada. Electronic address: gad.sabbatier.1@ulaval.ca.
authors.forename: Gad
authors.initials: G
authors.lastname: Sabbatier
authors.affiliation: Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de génie des mines, de la métallurgie et des matériaux, Université Laval 1045 avenue de la Médecine, Bureau 1033, Québec, G1V 0A6 Québec, Canada; Centre de recherche du CHU de Québec, Hôpital St François d'Assise, 10 rue de l'Espinay, local E0-165, Québec (QC), G1L 3L5 Québec, Canada. Electronic address: pierre.abadie.1@ulaval.ca.
authors.forename: Pierre
authors.initials: P
authors.lastname: Abadie
authors.affiliation: Laboratoire de Physique et Mécanique Textile, École Nationale Supérieure d'Ingénieurs du Sud Alsace, Université de Haute Alsace, 11 rue Alfred Werner, 68093 Mulhouse Cedex, Mulhouse, France. Electronic address: florence.dieval@uha.fr.
authors.forename: Florence
authors.initials: F
authors.lastname: Dieval
authors.affiliation: Laboratoire de Physique et Mécanique Textile, École Nationale Supérieure d'Ingénieurs du Sud Alsace, Université de Haute Alsace, 11 rue Alfred Werner, 68093 Mulhouse Cedex, Mulhouse, France. Electronic address: bernard.durand@uha.fr.
authors.forename: Bernard
authors.initials: B
authors.lastname: Durand
authors.affiliation: Laboratoire d'Ingénierie de Surface, Centre de Recherche sur les Matériaux Avancés, Département de génie des mines, de la métallurgie et des matériaux, Université Laval 1045 avenue de la Médecine, Bureau 1033, Québec, G1V 0A6 Québec, Canada; Centre de recherche du CHU de Québec, Hôpital St François d'Assise, 10 rue de l'Espinay, local E0-165, Québec (QC), G1L 3L5 Québec, Canada. Electronic address: gaetan.laroche@gmn.ulaval.ca.
authors.forename: Gaétan
authors.initials: G
authors.lastname: Laroche
mesh_terms: D000388:Air; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D003460:Crystallization / Q000379:methods; D019544:Equipment Failure Analysis; D019344:Lactic Acid / Q000138:chemical synthesis*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis*; D011474:Prosthesis Design; D012399:Rotation; D013499:Surface Properties; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds
chemical_list: D046911:Macromolecular Substances; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)
keywords: Multilinear regression; Nanofibre scaffold; Poly(lactic acid); Spinning; Vascular regenerative medicine