title: NCOA5, IL-6, type 2 diabetes, and HCC: The deadly quartet.
abstract: Although type 2 diabetes (T2D) is an established risk factor for hepatocellular carcinoma (HCC), the underlying mechanism that connects these two diseases is unknown. Gao et al. (2013) now suggest that nuclear receptor coactivator 5 (NCOA5) provides a genetic link between the two diseases through its effects on hepatic IL-6 expression.
authors.affiliation: Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA.
authors.forename: Debanjan
authors.initials: D
authors.lastname: Dhar
authors.affiliation: Department of Medicine, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA.
authors.forename: Ekihiro
authors.initials: E
authors.lastname: Seki
authors.affiliation: Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA; Moores UCSD Cancer Center, University of California, San Diego, School of Medicine, 9500 Gilman Drive, San Diego, CA 92093, USA. Electronic address: karinoffice@ucsd.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Karin
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D005260:Female; D018149:Glucose Intolerance / Q000209:etiology*; D057895:Haploinsufficiency; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D008297:Male; D056918:Nuclear Receptor Coactivators / Q000235:genetics*
chemical_list: D056918:Nuclear Receptor Coactivators