title: Intramolecular interactions of a phenyl/perfluorophenyl pair in the formation of supramolecular nanofibers and hydrogels.
abstract: A new system for the incorporation of a phenyl/perfluorophenyl pair in the structure of a peptide hydrogelator was developed. The strategy is based on the idea that the integration of an end-capped perfluorophenyl group and a phenylalanine with a phenyl moiety in the side chain forms an intramolecular phenyl/perfluorophenyl pair, which can be used to promote the formation of the supramolecular nanofibers and hydrogels. This work illustrates the importance of structure-hydrogelation relationship and provides new insights into the design of self-assembly nanobiomaterials.
authors.affiliation: Department of Materials Science and Engineering, National Chiao Tung University, Hsinchu, 300, Taiwan (Republic of China).
authors.forename: Shu-Min
authors.initials: SM
authors.lastname: Hsu
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Lin
authors.forename: Jui-Wen
authors.initials: JW
authors.lastname: Chang
authors.forename: Yu-Hao
authors.initials: YH
authors.lastname: Liu
authors.forename: Hsin-Chieh
authors.initials: HC
authors.lastname: Lin
mesh_terms: D000595:Amino Acid Sequence; D005464:Fluorobenzenes / Q000737:chemistry*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008969:Molecular Sequence Data; D057139:Nanofibers / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D010649:Phenylalanine / Q000737:chemistry
chemical_list: D005464:Fluorobenzenes; D020100:Hydrogels; D010455:Peptides; D010649:Phenylalanine
keywords: hydrogels; nanofibers; noncovalent interactions; self-assembly; supramolecular chemistry