title: Laser fractional photothermolysis of the skin: numerical simulation of microthermal zones.
abstract: BACKGROUND
  Laser Fractional Photothermolysis (FP) is one of the innovative techniques for skin remodeling and resurfacing. During treatment, the control of the Microscopic Thermal Zones' (MTZs) dimensions versus pulse energy requires detailed knowledge of the various parameters governing the heat transfer process. In this study, a mathematical model is devised to simulate the effect of pulse energy variations on the dimensions of MTZs.
  
  
  METHODS
  Two series of simulations for ablative (10.6 μm CO2) and non-ablative (1.550 μm Er:Glass) lasers systems were performed. In each series, simulations were carried for the following pulses energies: 5, 10, 15, 20, 25, 30, 35, and 40 mJ. Results of simulations are validated by histological analysis images of MTZs sections reported in works by Hantash et al. and Bedi et al.
  
  
  RESULTS
  MTZs dimensions were compared between histology and those achieved using our simulation model using fusion data technique for both ablative FP and non-ablative FP treatment methods. Depths and widths from simulations are usually deeper (21 ± 2%) and wider (12 ± 2%) when compared with histological analysis data.
  
  
  CONCLUSIONS
  When accounting for the shrinkage effect of excision of cutaneous tissues, a good correlation can be established between the simulation and the histological analysis results.
authors.affiliation: INSERM (French National Institute of Health and Medical Research) U703.
authors.forename: Mohamad Feras
authors.initials: MF
authors.lastname: Marqa
authors.forename: Serge
authors.initials: S
authors.lastname: Mordon
mesh_terms: D003357:Cosmetic Techniques; D019583:Dose Fractionation, Radiation; D006801:Humans; D054020:Lasers, Gas / Q000627:therapeutic use*; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D012867:Skin