title: N-acetyl-D-mannosamine treatment alleviates age-related decline in place-learning ability in dogs.
abstract: This study aimed to investigate the therapeutic effects of N-acetyl-D-mannosamine (ManNAc) on age-related cognitive dysfunction in dogs. ManNAc was administered to 5 dogs with low cognitive levels for 2 months, and the cognitive ability and active-resting cycle were periodically assessed for improvement. ManNAc treatment significantly reduced the number of error trials in the place-learning test, especially in the first month of administration. Three ManNAc-treated dogs also showed improvement in the active-resting cycle. In conclusion, ManNAc treatment appears to alleviate age-related cognitive dysfunction.
authors.affiliation: Department of Animal Science and Biotechnology, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Nagasawa
authors.forename: Aki
authors.initials: A
authors.lastname: Shimozawa
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Mogi
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kikusui
mesh_terms: D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000704:Analysis of Variance; D000818:Animals; D018592:Cross-Over Studies; D004285:Dogs; D005260:Female; D006595:Hexosamines / Q000494:pharmacology*; D007564:Japan; D008297:Male; D009483:Neuropsychological Tests; D065853:Spatial Learning / Q000187:drug effects* / Q000502:physiology
chemical_list: D006595:Hexosamines; C002022:N-acetylmannosamine