title: Role of lens vault in subtypes of angle closure in Iranian subjects.
abstract: OBJECTIVE
  The purpose of this study is to quantify anterior chamber (AC) parameters and to determine the proportion of eyes with exaggerated lens vault (LV) in different subtypes of angle closure disease using anterior segment optical coherence tomography (AS-OCT).
  
  
  METHODS
  In this prospective study, 115 eyes of 115 Iranian patients with angle closure disease were included and categorized into three groups: (1) fellow eyes of acute angle closure (AAC; 40 eyes); (2) primary angle closure glaucoma (PACG; 39 eyes); and (3) primary angle closure suspect (PACS; 36 eyes). Complete ophthalmic examination including gonioscopy, A-scan biometry, and AS-OCT were performed. Angle parameters, LV, and iris thickness (IT) were measured using AS-OCT. An exaggerated LV was defined as LV more than one-third the distance between the corneal endothelium and a line drawn to connect the nasal and temporal scleral spurs.
  
  
  RESULTS
  Fellow eyes of AAC had the shallower AC (P=0.01), greater iris curvature (I-curve; P=0.01), and higher LV (P=0.02) as compared with PACS and PACG eyes. There was no statistically significant difference in the mean IT at 750 μm from scleral spur among the three groups (P=0.45). Exaggerated LV was found in 67.5, 35.9, and 40% of fellow eyes of AAC, PACG, and PACS, respectively, (P=0.008) with an odds ratio of 1.92 (P=0.005) for fellow vs PACG and 1.68 (P=0.01) for fellow vs PACS.
  
  
  CONCLUSIONS
  Exaggerated LV is highly prevalent in fellow eyes of AAC. These eyes have shallower AC depth, greater I-curve, and higher LV when compared with PACG and PACS.
authors.affiliation: 1] Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran [2] Glaucoma Division, Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA [3] Koret Vision Center, University of California, San Francisco Medical School, San Francisco, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Moghimi
authors.affiliation: Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Vahedian
authors.affiliation: Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: N
authors.initials: N
authors.lastname: Zandvakil
authors.affiliation: Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Mohammdi
authors.affiliation: Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Science, Tehran, Iran.
authors.forename: G
authors.initials: G
authors.lastname: Fakhraie
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
authors.forename: N
authors.initials: N
authors.lastname: Nassiri
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Coleman
authors.affiliation: Koret Vision Center, University of California, San Francisco Medical School, San Francisco, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Lin
mesh_terms: D000867:Anterior Chamber / Q000503:physiopathology*; D001699:Biometry; D003430:Cross-Sectional Studies; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000145:classification / Q000503:physiopathology*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D007492:Iran; D007499:Iris Diseases / Q000175:diagnosis / Q000503:physiopathology*; D007905:Lens Diseases / Q000175:diagnosis / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular