title: In vitro maturation of oocytes is not a risk factor for adult metabolic syndrome of mouse offspring.
abstract: OBJECTIVE
  To evaluate the effect of in vitro maturation (IVM) of oocytes on the serum cholesterol profile, glucose and insulin tolerance, blood pressure, and heart rate of adult mouse offspring.
  
  
  METHODS
  The serum cholesterol profile, glucose and insulin tolerance, blood pressure, and heart rate of adult offspring born from in vitro matured oocytes were compared with those of adult offspring born from in vivo matured oocytes.
  
  
  RESULTS
  Offspring born from in vitro matured oocytes showed a normal serum cholesterol profile. In the glucose tolerance test, glucose levels were consistently elevated in adult offspring born from in vitro matured oocytes compared with those born from in vivo matured oocytes, but the differences did not reach statistical significance. There were no significant differences in insulin tolerance, blood pressure, and heart rate between adult offspring born from in vitro matured oocytes and those from in vivo matured oocytes.
  
  
  CONCLUSIONS
  No alterations were found in the metabolism profile of adult mouse offspring born from in vitro matured oocytes compared with that from in vivo matured oocytes.
authors.affiliation: Department of Obstetrics and Gynecology, Jinan Central Hospital Affiliated to Shandong University, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Obstetrics and Gynecology, Jinan Central Hospital Affiliated to Shandong University, China.
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Jia
authors.affiliation: Department of Reproductive Medicine, Jinan Central Hospital Affiliated to Shandong University, China.
authors.forename: Xi-Lan
authors.initials: XL
authors.lastname: Lu
authors.affiliation: Department of Pain Management, Jinan Central Hospital Affiliated to Shandong University, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Department of Psychiatry, Mental Health Center of Shandong Province, China.
authors.forename: Kai-Yong
authors.initials: KY
authors.lastname: Tian
authors.affiliation: Department of Reproductive Medicine, Jinan Central Hospital Affiliated to Shandong University, China.
authors.forename: Jun-Tao
authors.initials: JT
authors.lastname: Li
authors.affiliation: Department of Reproductive Medicine, Jinan Central Hospital Affiliated to Shandong University, China. Electronic address: zhang_1974217@sina.com.
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002478:Cells, Cultured; D002784:Cholesterol / Q000097:blood; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005951:Glucose Tolerance Test; D006339:Heart Rate; D059471:In Vitro Oocyte Maturation Techniques; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009865:Oocytes / Q000254:growth & development*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D002784:Cholesterol
keywords: Adult metabolic syndrome; In vitro maturation; Oocyte