title: Dearomatization strategy and palladium-catalyzed domino reaction: construction of azepino[5,4,3-cd]indoles from 2-alkynylanilines.
abstract: A facile approach to construct 3,4-fused tricyclic azepino[5,4,3-cd]indoles from 2-alkynyl anilines, isocyanides, and α,β-unsaturated acids is reported. This synthetic process involves a regioselective meta-functionalization of 2-alkynylanilines using a dearomatization strategy and a palladium(II)-catalyzed domino heterocyclization/Heck reaction.
authors.affiliation: Department of Chemistry, Fudan University , 220 Handan Road, Shanghai 200433, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zheng
authors.forename: Jin Jin
authors.initials: JJ
authors.lastname: Chen
authors.forename: Renhua
authors.initials: R
authors.lastname: Fan
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D001381:Azepines / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000814:Aniline Compounds; D001381:Azepines; D007211:Indoles; D010165:Palladium; C023650:aniline