title: Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: a meta-analysis.
abstract: OBJECTIVE
  To clarify the current understanding of the association between interleukin-10 (IL-10) polymorphisms and the risk of irritable bowel syndrome (IBS).
  
  
  METHODS
  We searched for studies in any language recorded in PubMed, Embase and Cochrane library before August 2013. The associations under allele contrast model, codominant model, dominant model, and recessive model were analyzed. The strengths of the association between IL-10 polymorphisms and IBS risk were estimated using odds ratios (OR) with 95% confidence interval (CI). Fixed effects model was used to pool the result if the test of heterogeneity was not significant, otherwise the random-effect model was selected.
  
  
  RESULTS
  Eight case-control studies analyzing three single-nucleotide polymorphisms rs1800870 (-1082 A/G), rs1800871 (-819C/T), and rs1800872 (-592A/C) of the IL-10 gene, which involved 928 cases and 1363 controls, were eligible for our analysis. The results showed that rs1800870 polymorphisms were associated with a decreased risk of IBS (GG+GA vs AA: OR = 0.80, 95%CI: 0.66-0.96), (AA+GA vs GG: OR = 0.68, 95%CI: 0.52-0.90). Subgroup analysis revealed such association only existed in Caucasian ethnicity (AA+GA vs GG, OR = 0.70, 95%CI: 0.55-0.89). The rs1800872 polymorphisms were associated with an increased risk of IBS in Asian ethnicity (CC vs GG: OR = 1.29, 95%CI: 1.01-1.16). There were no associations between rs1800871 polymorphisms and the IBS risk.
  
  
  CONCLUSIONS
  The results suggest that IL-10 rs1800870 confers susceptibility to the risk of IBS in Caucasian ethnicity, and the rs1800872 may associate with IBS risk in Asians. However, no significant associations are found between rs1800871 and IBS risk.
authors.affiliation: Shan-Yu Qin, Hai-Xing Jiang, Dong-Hong Lu, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Shan-Yu
authors.initials: SY
authors.lastname: Qin
authors.affiliation: Shan-Yu Qin, Hai-Xing Jiang, Dong-Hong Lu, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Hai-Xing
authors.initials: HX
authors.lastname: Jiang
authors.affiliation: Shan-Yu Qin, Hai-Xing Jiang, Dong-Hong Lu, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: Dong-Hong
authors.initials: DH
authors.lastname: Lu
authors.affiliation: Shan-Yu Qin, Hai-Xing Jiang, Dong-Hong Lu, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China.
authors.forename: You
authors.initials: Y
authors.lastname: Zhou
mesh_terms: D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D043183:Irritable Bowel Syndrome / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: C508609:IL10 protein, human; D016753:Interleukin-10
keywords: Case-control; Gene polymorphism; Interleukin-10; Irritable bowel syndrome; Meta-analysis