title: Effect of alpha-resorcylic acid-L-phenylalanine amide on collagen synthesis and matrix metalloproteinase expression in fibroblasts.
abstract: Regulation of collagen synthesis and matrix metalloproteinases (MMPs) expression levels has been an important issue in medicinal, pharmaceutical and cosmetic industries. Herein, α-Resorcylic acid-phenylalanine amide (α-RA-F) was prepared and its biological activities were observed. We found that α-RA-F boosted collagen synthesis and reduced MMPs expression levels in human fibroblasts without cytotoxicity.
authors.affiliation: Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea.
authors.forename: Seon-Yeong
authors.initials: SY
authors.lastname: Kwak
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea.
authors.forename: Jin-Mi
authors.initials: JM
authors.lastname: Noh
authors.affiliation: R&D Center, Bioland Ltd., Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea.
authors.forename: Suyeon
authors.initials: S
authors.lastname: Lee
authors.affiliation: R&D Center, Bioland Ltd., Byeongcheon, Dongnam, Cheonan, Chungnam 330-863, Republic of Korea.
authors.forename: So Hun
authors.initials: SH
authors.lastname: Lee
authors.affiliation: Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea.
authors.forename: Su-ji
authors.initials: SJ
authors.lastname: Jeon
authors.affiliation: Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea.
authors.forename: Hye-In
authors.initials: HI
authors.lastname: Kim
authors.affiliation: Department of Chemical Engineering, Hanyang University, Ansan 426-791, Republic of Korea. Electronic address: kjh75@hanyang.ac.kr.
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Kim
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea. Electronic address: yslee@snu.ac.kr.
authors.forename: Yoon-Sik
authors.initials: YS
authors.lastname: Lee
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry / Q000494:pharmacology*; D020782:Matrix Metalloproteinases / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D012118:Resorcinols / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D062385:Hydroxybenzoates; D012333:RNA, Messenger; D012118:Resorcinols; C076950:alpha-resorcylic acid; D010649:Phenylalanine; C020457:phenylalanine amide; D003094:Collagen; D020782:Matrix Metalloproteinases
keywords: Collagen synthesis; Resorcylic acid derivative; Suppression of MMPs expression