title: Hemocompatibility improvement of poly(ethylene terephthalate) via self-polymerization of dopamine and covalent graft of zwitterions.
abstract: Poly (ethylene terephthalate) (PET) has been widely adopted as a scaffold biomaterial, but further hemocompatibility improvement is still needed for wide biomedical applications. Inspired by the composition of adhesive proteins in mussels, we propose to use self-polymerized dopamine to form a surface-adherent polydopamine layer onto PET sheet, followed by Michael addition with N,N-dimethylethylenediamine (DMDA) to build tertiary amine, and final zwitterions(sulfobetaine and carboxybetaine) construction through ring-opening reaction. Physicochemical properties of substrates were demonstrated by water contact angle measurement, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The hemocompatibility was evaluated by platelet adhesion, hemolytic, and protein adsorption. The results showed that the zwitterions immobilized PET endowed with improved resistance to nonspecific protein adsorption and platelet adhesion as well as nonhemolytic. The zwitterions with desirable hemocompatibility can be readily tailored to catheter for various biomedical applications.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Xianmei
authors.initials: X
authors.lastname: Cai
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. Electronic address: bioalchem@yahoo.com.
authors.forename: Jiang
authors.initials: J
authors.lastname: Yuan
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Shuangchun
authors.initials: S
authors.lastname: Chen
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China. Electronic address: lili3@njnu.edu.cn.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D002417:Cattle; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D008422:Materials Testing / Q000379:methods*; D056951:Photoelectron Spectroscopy; D010973:Platelet Adhesiveness; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000494:pharmacology; D011093:Polyethylene Terephthalates; D058105:Polymerization / Q000187:drug effects; D011108:Polymers / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D007211:Indoles; D007477:Ions; D011093:Polyethylene Terephthalates; D011108:Polymers; C568283:polydopamine; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols
keywords: Hemocompatibility; Poly(dopamine); Poly(ethylene terephthalate); Surface modification; Zwitterions