title: High aspect ratio elongated microparticles for enhanced topical drug delivery in human volunteers.
abstract: Delivery of therapeutics into skin is hindered by the epidermal barriers. To overcome these barriers for the treatment of skin diseases, a cutaneous delivery method capable of field treatment using silica-elongated microparticles is developed. The microparticles are massaged into the skin using a 3D-printed microtextured applicator resulting in significant field-directed drug delivery enhancement.
authors.affiliation: Dermatology Research Centre, The University of Queensland, School of Medicine, Translational Research Institute, Brisbane, Australia, Brisbane, 4102, QLD, Australia.
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Raphael
authors.forename: Clare A
authors.initials: CA
authors.lastname: Primiero
authors.forename: Lynlee L
authors.initials: LL
authors.lastname: Lin
authors.forename: Ross Flewell
authors.initials: RF
authors.lastname: Smith
authors.forename: Philip
authors.initials: P
authors.lastname: Dyer
authors.forename: H Peter
authors.initials: HP
authors.lastname: Soyer
authors.forename: Tarl W
authors.initials: TW
authors.lastname: Prow
mesh_terms: D000279:Administration, Cutaneous; D004337:Drug Carriers / Q000737:chemistry*; D019793:Fluorescein / Q000008:administration & dosage / Q000737:chemistry; D064368:Healthy Volunteers; D006801:Humans; D066298:In Vitro Techniques; D018613:Microscopy, Confocal; D008863:Microspheres; D012822:Silicon Dioxide / Q000737:chemistry; D012867:Skin / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D012822:Silicon Dioxide; D019793:Fluorescein
keywords: drug delivery; microneedles; microparticles; silica; skin