title: [Pharmacokinetics and bioavailability of ginsenoside Rg1 in rats].
abstract: OBJECTIVE
  To investigate the pharmacokinetics and bioavailability of ginsenoside Rg1 in rats.
  
  
  METHODS
  Ginsenoside Rg1 was oral administered or intravenous administered to each rat. The plasma concentration of ginsenoside Rg1 was estimated by RP-HPLC. 3P97 software was used to calculate pharmacokinetic parameters.
  
  
  RESULTS
  Main parameters of ginsenoside Rg1 after oral or intravenous administered were: AUC(0 --> t), 322.70 +/- 20.78, 99.76 +/- 8.91 microg x h/mL, CL 0.08 +/- 0.02, 3.01 +/- 0.69 L/(kg x h), V 0.23 +/- 0.01, 22.75 +/- 2.09 L/kg, t1/2alpha 0.48 +/- 0.18, 0.87 +/- 0.21 h, t1/2beta 19.57 +/- 2.81, 18.68 +/- 2.74 h, MRT6.91 +/- 0.99, 8.15 +/- 1.05 h(-1), respectively. The relative oral bioavailability of ginsenoside Rg1 was 2.5%.
  
  
  CONCLUSIONS
  The oral bioavailability of ginsenoside Rg1 is very low.
authors.affiliation: Guangxi Medical University, Nanning 530021, China. yuan6www@163.com
authors.forename: Zhen-Yuan
authors.initials: ZY
authors.lastname: Tan
authors.affiliation: Guangxi Health College, Nanning 530021, China.
authors.forename: Wang-Na
authors.initials: WN
authors.lastname: Xiong
authors.affiliation: Guangxi Medical University, Nanning 530021, China.
authors.forename: Xing-Zhen
authors.initials: XZ
authors.lastname: Huang
authors.affiliation: Guangxi University of Chinese Medicine, Nanning 530001, China.
authors.forename: Jian-Qin
authors.initials: JQ
authors.lastname: Liang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D036145:Ginsenosides / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D007262:Infusions, Intravenous; D008297:Male; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; C035054:ginsenoside Rg1