title: Evaluation of pneumococcal PCR and urinary antigen detection in children.
abstract: BACKGROUND
  The rapid detection of Streptococcus pneumoniae could assist in the management of pneumococcal infections. The Binax NOW S. pneumoniae test is a rapid immunochromatographic test for this purpose.
  
  
  METHODS
  Multiplex PCR in parapneumonic pleural effusion fluid (PPEF) and cerebrospinal fluid (CSF) with Binax NOW urinary pneumococcal antigen test (PAT) from 80 children was compared in this study.
  
  
  RESULTS
  PAT had a sensitivity of 36.4%, specificity of 97.3%, in CSF. PAT had a sensitivity of 50%, specificity of 81% for parapneumonic pleural effusion fluid.
  
  
  CONCLUSIONS
  When rapid management of a serious infection is needed the Binax NOW test could be a reliable method for the exclusion of S. pneumoniae infection.
authors.affiliation: Hacettepe University Pediatric Infectious Diseases Department, Ankara, Turkey. aslinur.o@gmail.com
authors.forename: Aslinur Ozkaya
authors.initials: AO
authors.lastname: Parlakay
authors.affiliation: Hacettepe University Pediatric Infectious Diseases Department, Ankara, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ceyhan
authors.affiliation: Hacettepe University Pediatric Infectious Diseases Department, Ankara, Turkey.
authors.forename: Melda
authors.initials: M
authors.lastname: Celik
authors.affiliation: Hacettepe University Pediatric Infectious Diseases Department, Ankara, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Ozsürekci
authors.affiliation: Hacettepe University Pediatric Infectious Diseases Department, Ankara, Turkey.
authors.forename: Eda
authors.initials: E
authors.lastname: Karadağ Oncel
authors.affiliation: On Dokuz Mayis University Pediatric Infectious Diseases Department, Samsun, Turkey.
authors.forename: Gulnar
authors.initials: G
authors.lastname: Sensoy
authors.affiliation: On Dokuz Mayis University Pediatric Infectious Diseases Department, Samsun, Turkey.
authors.forename: Nursen
authors.initials: N
authors.lastname: Belet
authors.affiliation: Necmettin Erbakan University Pediatric Infectious Diseases Department, Konya, Turkey.
authors.forename: Melike Keser
authors.initials: MK
authors.lastname: Emiroglu
authors.affiliation: Hacettepe University Pediatric Infectious Diseases Department, Ankara, Turkey.
authors.forename: Ahmet Emre
authors.initials: AE
authors.lastname: Aycan
authors.affiliation: Hacettepe University Pediatric Infectious Diseases Department, Ankara, Turkey.
authors.forename: Kumsal
authors.initials: K
authors.lastname: Cağlar
mesh_terms: D000942:Antigens, Bacterial / Q000652:urine*; D002648:Child; D002846:Chromatography, Affinity; D006801:Humans; D060885:Multiplex Polymerase Chain Reaction / Q000379:methods*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013296:Streptococcus pneumoniae / Q000235:genetics / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial