title: Idiopathic aplastic anemia: diagnosis and classification.
abstract: Aplastic anemia (AA) is a disease characterized by pancytopenia and hypoplastic bone marrow caused by the decrease of hematopoietic stem cells. The pathogenesis of AA is complex and involves an abnormal hematopoietic microenvironment, hematopoietic stem cell/progenitor cell deficiencies and immunity disorders. Survival in severe aplastic anemia (SAA) has markedly improved in the past 4 decades because of advances in hematopoietic stem cell transplantation, immunosuppressive and biologic drugs, and supportive care. Herein, we will update the main issues concern AA according to our literature review.
authors.affiliation: Hematology Unit, Meir Medical Center, Kfar-Saba, Israel.
authors.forename: Osnat Jarchowsky
authors.initials: OJ
authors.lastname: Dolberg
authors.affiliation: Department of Medicine 'E', Meir Medical Center, Kfar-Saba, Israel. Electronic address: levy.yair@clalit.org.il.
authors.forename: Yair
authors.initials: Y
authors.lastname: Levy
mesh_terms: D000741:Anemia, Aplastic / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000378:metabolism; D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology; D016615:Telomere / Q000235:genetics
chemical_list: D001323:Autoantibodies; D007166:Immunosuppressive Agents
keywords: Aplastic anemia; Autoimmunity; Immunosuppressive therapy; Pancytopenia