title: Balo concentric sclerosis in children: a case series.
abstract: Baló concentric sclerosis is a unique and rare phenomenon in demyelinating disease. Typically thought of as a subtype of multiple sclerosis, Baló concentric sclerosis is characterized pathologically by striking rings of demyelination alternating with areas of preserved myelination. Its exact prevalence in adult and especially pediatric populations is unknown. Although traditionally considered to be an acute and fatal disease of adults, there are a handful of reports of Baló concentric sclerosis cases in pediatric patients. Here we report Baló concentric sclerosis-like demyelinating disease in 3 female pediatric patients, representing 2.2% of a cohort of 134 pediatric patients with demyelinating diseases who have been seen in our center since 2005. The relatively high prevalence of Baló concentric sclerosis-like cases in our pediatric demyelinating diseases center, none of which have been fatal, supports the premise that the developing immune and central nervous systems may manifest and respond to demyelinating disease differently from adults.
authors.affiliation: 1Partners Pediatric Multiple Sclerosis Center, Department of Child Neurology, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Jenny
authors.initials: J
authors.lastname: Linnoila
authors.forename: Tanuja
authors.initials: T
authors.lastname: Chitnis
mesh_terms: D000293:Adolescent; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002549:Diffuse Cerebral Sclerosis of Schilder / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D013116:Spinal Cord / Q000473:pathology
keywords: Balo; all pediatric; multiple sclerosis