title: Therapeutic amnioinfusion for chronic abruption-oligohydramnios sequence: a possible prevention of the infant respiratory disease.
abstract: Chronic abruption-oligohydramnios sequence (CAOS), characterized by chronic vaginal bleeding and oligohydramnios, is associated with adverse pregnancy outcomes, including preterm delivery and lung problems in the infant. Fetal lung damage may be induced by not only oligohydramnios but also iron-induced oxidative stress through chronic aspiration of bloody substances in amniotic fluid. We describe a pregnancy complicated with CAOS that was managed with repeated amnioinfusions. This is the first report showing that amnioinfusions succeeded in a significant reduction in high concentrations of iron, lactose dehydrogenase, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative DNA damage, in the amniotic fluid complicated by CAOS. The baby, born at 26 weeks' gestation via cesarean, was discharged home without supplemental oxygen 116 days after birth.
authors.affiliation: Department of Gynecology and Obstetrics, Kyoto University, Kyoto, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Morita
authors.forename: Eiji
authors.initials: E
authors.lastname: Kondoh
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Kohei
authors.initials: K
authors.lastname: Fujita
authors.forename: Haruta
authors.initials: H
authors.lastname: Mogami
authors.forename: Sachiko
authors.initials: S
authors.lastname: Minamiguchi
authors.forename: Ikuo
authors.initials: I
authors.lastname: Konishi
mesh_terms: D000037:Abruptio Placentae / Q000503:physiopathology / Q000628:therapy*; D000328:Adult; D002585:Cesarean Section; D005260:Female; D005440:Fluid Therapy / Q000009:adverse effects; D006801:Humans; D007231:Infant, Newborn; D007564:Japan; D008297:Male; D016104:Oligohydramnios / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D047928:Premature Birth; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology / Q000517:prevention & control*; D035703:Therapies, Investigational / Q000009:adverse effects; D016896:Treatment Outcome; D055815:Young Adult
keywords: amnioinfusion; chronic abruption-oligohydramnios sequence; diffuse chorioamniotic hemosiderosis; lung injury; oxidative stress