title: 5alpha,8alpha-epidioxysterols from a Formosan sponge, Axinyssa sp.
abstract: One new 5alpha,8alpha-epidioxysterol, 3-acetylaxinysterol (1), along with one known sterol, axinysterol (2), were isolated from a Formosan sponge, Axinyssa sp.. The structures of the compounds were determined by spectroscopic methods and the absolute configuration of 2 was further confirmed by single-crystal X-ray diffraction analysis for the first time. Compound 2 exhibited significant cytotoxicity against K562 and Molt 4 cancer cell lines.
authors.affiliation: Antai Medical Care Cooperation Antai Tian-Sheng Memorial Hospital, Pingtung 928, Taiwan.
authors.forename: Tzu-Rong
authors.initials: TR
authors.lastname: Su
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors.forename: Kai-Ju
authors.initials: KJ
authors.lastname: Liang
authors.affiliation: Department of Chemistry, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors.forename: Mei-Chin
authors.initials: MC
authors.lastname: Lu
authors.affiliation: Department ofBeauty Science, Meiho University, Pingtung 912, Taiwan.
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Wue
authors.affiliation: National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
mesh_terms: D000818:Animals; D004146:Dioxanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D011161:Porifera / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: D004146:Dioxanes; C083899:axinylsterol; D004875:Ergosterol