title: Serum Paraoxonase (PON1) Activity in North-West Indian Punjabi's with Acute Myocardial Infarction.
abstract: Human serum paraoxonase-1 (PON1), an enzyme on HDL prevents oxidation of LDL thereby preventing the development of atherosclerosis. Studies done so far have lead to conflicting results. As studies are lacking in North-West Indian Punjabi's, a distinct ethnic group with high incidence of coronary artery disease, we determined PONase activity in this population. It has been postulated that sudden lowering of serum PONase may lead to precipitation of acute myocardial infarction. We determined serum PONase activity and lipids in 100 patients each of AMI (within 24 h of onset), stable CAD and 100 age and sex matched healthy controls. These were again determined after 6 weeks in AMI patients. The mean serum PONase activity was lowest in AMI patients (23.26 U/ml) followed by stable CAD patients (102.0 U/ml) where as in controls was highest (179.8 U/ml). In patients with AMI, activity was significantly higher at 6 weeks as compared to that after acute event (49.39 %; p < 0.05). Sudden lowering of serum PONase activity in a population which already has lower activity may be one of the risk factors for development of AMI.
authors.affiliation: Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, 4th Floor, Block F, Room 16, Nehru Hospital, Chandigarh, 160012 INDIA.
authors.forename: V Nagarjuna
authors.initials: VN
authors.lastname: Maturu
authors.affiliation: Department of Biochemistry, PGIMER, Chandigarh, India.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Gupta
authors.affiliation: Department of Cardiology, PGIMER, Chandigarh, India.
authors.forename: Gagandip
authors.initials: G
authors.lastname: Singh
authors.affiliation: Department of Biochemistry, PGIMER, Chandigarh, India.
authors.forename: Kirandip
authors.initials: K
authors.lastname: Gill
authors.affiliation: Department of Cardiology, PGIMER, Chandigarh, India.
authors.forename: Yash Paul
authors.initials: YP
authors.lastname: Sharma
authors.affiliation: Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, 4th Floor, Block F, Room 16, Nehru Hospital, Chandigarh, 160012 INDIA.
authors.forename: Surjit
authors.initials: S
authors.lastname: Singh
keywords: Acute myocardial infarction; Atherosclerosis; Coronary artery disease; Paraoxonase-1