title: Anti-complementary constituents of Houttuynia cordata and their targets in complement activation cascade.
abstract: Activity-guided fractionation for complement inhibitors led to the isolation of 23 known compounds from Houttuynia cordata Thunb. Seven flavonoids, two alkaloids, one coumarin and two phenols showed anti-complementary activity. Preliminary inhibitory mechanism of four flavonoids, including quercitrin, afzelin, isoquercitrin and quercetin in the complement activation cascade were examined for the first time. The results indicated that the target components of flavonols are different from those of flavonosides, and the glycoside moieties may be necessary to block C3 and C4 components.
authors.affiliation: a Department of Pharmacognosy , School of Pharmacy, Fudan University , Shanghai 201203 , P.R. China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Lu
authors.forename: Yun-Yi
authors.initials: YY
authors.lastname: Zhang
authors.forename: Dao-Feng
authors.initials: DF
authors.lastname: Chen
mesh_terms: D000470:Alkaloids / Q000494:pharmacology; D003167:Complement Activation / Q000187:drug effects; D003176:Complement C3 / Q000187:drug effects; D003181:Complement C4 / Q000187:drug effects; D003374:Coumarins / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000494:pharmacology; D052859:Houttuynia / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000494:pharmacology; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D003176:Complement C3; D003181:Complement C4; D003374:Coumarins; D005419:Flavonoids; D006027:Glycosides; D010636:Phenols; C016527:isoquercitrin; C012526:quercitrin; D011794:Quercetin