title: Therapeutic approaches against common structural features of toxic oligomers shared by multiple amyloidogenic proteins.
abstract: Impaired proteostasis is one of the main features of all amyloid diseases, which are associated with the formation of insoluble aggregates from amyloidogenic proteins. The aggregation process can be caused by overproduction or poor clearance of these proteins. However, numerous reports suggest that amyloid oligomers are the most toxic species, rather than insoluble fibrillar material, in Alzheimer's, Parkinson's, and Prion diseases, among others. Although the exact protein that aggregates varies between amyloid disorders, they all share common structural features that can be used as therapeutic targets. In this review, we focus on therapeutic approaches against shared features of toxic oligomeric structures and future directions.
authors.affiliation: Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX, USA; Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Marcos J
authors.initials: MJ
authors.lastname: Guerrero-Muñoz
authors.affiliation: Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX, USA; Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.
authors.forename: Diana L
authors.initials: DL
authors.lastname: Castillo-Carranza
authors.affiliation: Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX, USA; Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: rakayed@utmb.edu.
authors.forename: Rakez
authors.initials: R
authors.lastname: Kayed
mesh_terms: D058227:Amyloidogenic Proteins / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D001704:Biopolymers / Q000737:chemistry* / Q000633:toxicity; D007167:Immunotherapy; D051379:Mice
chemical_list: D058227:Amyloidogenic Proteins; D001704:Biopolymers
keywords: Amyloid oligomers; Anle138b (http://www.cipsm.de/en/publications/researchAreaA/2013/Anle138b_a_novel_oligomer_modulator_for_disease-modifying_therapy_of_neurodegenerative_diseases_such_as_prion_and_Parkinson_s_disease/index.html?style=1); Anti-amyloid small molecules; Baicalein (PubChem CID: 5281605); CLR01 (http://www.med-chemist.com/2012/11/clr01-effectively-inhibits.html); Curcumin (PubChem CID: 969516); Epigallocatechingallate (PubChem CID: 65064); Immunotherapy; Methylene blue (PubChem CID: 6099); Oleuropein (PubChem CID: 5281544); Phenol Red (PubChem CID: 4766); Resveratrol (PubChem CID: 445154); Silibinin (PubChem CID: 31553)