title: Correlation between the Xba I polymorphism of apoB gene and serum lipid profiles in Li ethnic group.
abstract: OBJECTIVE
  To study correlation between the Xba I polymorphism of apoB gene and plasma lipid profiles in Li ethnic group.
  
  
  METHODS
  Total 151 cases of healthy Li people were recruited randomly by cluster sampling and 200 Han people were recruited as control; blood was drawn to analyze Xba I polymorphism distribution of apoB gene and serum lipid levels.
  
  
  RESULTS
  There were lower serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels in serum of Li people; while, high density lipoprotein cholesterol (HDL-C), X-/X+ genotype and X+ allele frequencies exhibited higher levels than Han people. Interestingly, HDL-C level was reduced, while LDL-C level was enhanced in subjects carrying heterozygous (X-/X+) genotype compared to homozygous (X-/X-) genotype. Additionally, there were no difference in serum level of triglyceride, TC, apoprotein A (apo A) and apoprotein B (apo B) between Li and Han people, the same results were showed between X-/X+ and X-/X- genotype carriers.
  
  
  CONCLUSIONS
  Xba I polymorphism of apoB gene is correlated to the profiles of serum lipid level, X-/X+ genotype carriers are phenotyped with higher LDL-C level and lower level of HDL-C in Li ethnic group.
authors.affiliation: School of Pharmacy, Hainan Medical College, Haikou 571101, P. R. China; Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China.
authors.forename: Yue-Li
authors.initials: YL
authors.lastname: Liu
authors.affiliation: Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China.
authors.forename: Yun-Bo
authors.initials: YB
authors.lastname: Zhang
authors.affiliation: Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China.
authors.forename: Rui-Lian
authors.initials: RL
authors.lastname: Ma
authors.affiliation: School of Science, Hainan Medical College, Haikou 571101, P. R. China.
authors.forename: Wang-Wei
authors.initials: WW
authors.lastname: Cai
authors.affiliation: School of Science, Hainan Medical College, Haikou 571101, P. R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Lin-Jiang
authors.affiliation: Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China.
authors.forename: Tian-Song
authors.initials: TS
authors.lastname: Wang
authors.affiliation: Department of Cardiology, People's hospital of Sanya, Sanya 572000, P. R. China; Affliated Hospital of Hainan Medical College, Hainan Medical College, Haikou 571101, P. R. China. Electronic address: yao.zhen@126.com.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yao
mesh_terms: D000704:Analysis of Variance; D001055:Apolipoproteins B / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016009:Chi-Square Distribution; D015252:Deoxyribonucleases, Type II Site-Specific; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D001055:Apolipoproteins B; D008055:Lipids; C025580:endodeoxyribonuclease XBAI; D015252:Deoxyribonucleases, Type II Site-Specific
keywords: ApoB gene; Li ethnic group; Lipid profile; Xba I polymorphism