title: Pd-carbene migratory insertion: application to the synthesis of trifluoromethylated alkenes and dienes.
abstract: Pd-catalyzed cross-coupling of halides with CF3-substituted diazo compounds or N-tosylhydrazones has been explored for the synthesis of CF3-substituted alkenes and 1,3-butadienes. Pd-carbene migratory insertion plays the key role in these transformations.
authors.affiliation: Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 (China), Fax: (+8610) 6275-1708.
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xu
authors.forename: Yifan
authors.initials: Y
authors.lastname: Deng
authors.forename: Yujing
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jiajie
authors.initials: J
authors.lastname: Feng
authors.forename: Guojing
authors.initials: G
authors.lastname: Ji
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry; D002070:Butadienes / Q000138:chemical synthesis* / Q000737:chemistry; D054879:Halogenation; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D008745:Methylation; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002070:Butadienes; C030011:carbene; D010165:Palladium; D008697:Methane
keywords: alkene synthesis; cross-coupling reactions; diazo compounds; palladium; trifluoromethylation