title: Comparison of stereotactic plans for brain tumors with two different multileaf collimating systems.
abstract: Linac-based stereotactic radiosurgery (SRS) has been widely used for treating small intracranial lesions. This technique allows conforming the dose distribution to the planning target volume (PTV), providing a steep dose gradient with the surrounding normal tissues. This is realized through dedicated collimation systems. The present study aims to compare SRS plans with two collimating systems: the beam modulator (BM) of the Elekta Synergy linac and the DirexGroup micromultileaf collimator (μMLC). Seventeen patients (25 PTVs) were planned both with BM and μMLC (mounted on an Elekta Precise linac) using the Odyssey (PerMedics) treatment planning system (TPS). Plans were compared in terms of dose-volume histograms (DVH), minimum dose to the PTV, conformity index (CI), and homogeneity index (HI), as defined by the TPS, and doses to relevant organs at risk (OAR). The mean difference between the μMLC and the BM plans in minimum PTV dose was 5.7% ± 4.2% in favor of the μMLC plans. No statistically significant difference was found between the distributions of the CI values for the two planning modalities (p = 0.54), while the difference between the distributions of the HI values was statistically significant (p = 0.018). For both BM and μMLC plans, no differences were observed in CI and HI, depending on lesion size and shape. The PTV homogeneity achieved by BM plans was 15.1% ± 6.8% compared to 10.4% ± 6.6% with μMLC. Higher maximum and mean doses to OAR were observed in the BM plans; however, for both plans, dose constraints were respected. The comparison between the two collimating systems showed no substantial differences in terms of PTV coverage or OAR sparing. The improvements obtained by using μMLC are relatively small, and both systems turned out to be adequate for SRS treatments.
authors.affiliation: Careggi University Hospital. livia.marrazzo@unifi.it.
authors.forename: Livia
authors.initials: L
authors.lastname: Marrazzo
authors.forename: Margherita
authors.initials: M
authors.lastname: Zani
authors.forename: Stefania
authors.initials: S
authors.lastname: Pallotta
authors.forename: Daniela
authors.initials: D
authors.lastname: Greto
authors.forename: Silvia
authors.initials: S
authors.lastname: Scoccianti
authors.forename: Cinzia
authors.initials: C
authors.lastname: Talamonti
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Biti
authors.forename: Marta
authors.initials: M
authors.lastname: Bucciolini
mesh_terms: D001932:Brain Neoplasms / Q000601:surgery*; D006801:Humans; D058958:Organs at Risk; D010315:Particle Accelerators; D016634:Radiosurgery / Q000295:instrumentation* / Q000379:methods; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D013238:Stereotaxic Techniques / Q000295:instrumentation*