title: Sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia.
abstract: OBJECTIVE
  To report a case of sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up.
  
  
  METHODS
  Observational case report of one patient.
  
  
  RESULTS
  A 31 year-old male with a history of cystic fibrosis presented with a central retinal vein occlusion (CRVO) in his left eye, followed by a CRVO in his right eye 4 years later. His medical workup was significant for elevated levels of homocysteine and gamma-globulins, which coincided with initiation of intravenous immunoglobulin (IVIG) proceeding his second CRVO.
  
  
  CONCLUSIONS
  We describe a case of sequential bilateral central retinal vein occlusions in a cystic fibrosis patient with hyperhomocysteinemia and hypergamma-globulinemia over 6 years of follow up and discuss the important role of these risk factors in retinal venous occlusive disease.
authors.affiliation: Department of Ophthalmology, Doheny Eye Institute, University of Southern California, Los Angeles, CA ; Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Rony
authors.initials: R
authors.lastname: Gelman
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Columbia University College of Physicians and Surgeons, New York, NY.
authors.forename: Emily A
authors.initials: EA
authors.lastname: DiMango
authors.affiliation: Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, NY ; Mannhattan Eye, Ear, and Throat Hospital, New York, NY.
authors.forename: William M
authors.initials: WM
authors.lastname: Schiff
keywords: IVIG; central retinal vein occlusion; cystic fibrosis; gamma-globulin; homocysteine