title: Keeping notch target genes off: a CSL corepressor caught in the act.
abstract: In this issue of Structure, Collins and colleagues report the structure of the Notch pathway component CSL bound to the corepressor KyoT2. The structure reveals that KyoT2 interacts with CSL in a configuration similar, but not identical to, the Notch RAM domain and provides insights into how CSL switches from an activator to a repressor.
authors.affiliation: Institute of Biochemistry, University of Giessen, Friedrichstrasse 24, 35392 Giessen, Germany.
authors.forename: Tilman
authors.initials: T
authors.lastname: Borggrefe
authors.affiliation: Center for Internal Medicine, Department of Internal Medicine I, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081 Ulm, Germany. Electronic address: franz.oswald@uni-ulm.de.
authors.forename: Franz
authors.initials: F
authors.lastname: Oswald
mesh_terms: D000818:Animals; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein / Q000737:chemistry*; D047908:Intracellular Signaling Peptides and Proteins / Q000737:chemistry*; D060588:LIM Domain Proteins / Q000737:chemistry*; D009124:Muscle Proteins / Q000737:chemistry*; D051880:Receptors, Notch / Q000737:chemistry*
chemical_list: C486306:Fhl1 protein, mouse; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; D009124:Muscle Proteins; C497571:Rbpj protein, mouse; D051880:Receptors, Notch