title: Comparative immunogenicity of two peste des petitis ruminants (PPR) vaccines in South Indian sheep and goats under field conditions.
abstract: Peste des petitis ruminants (PPR) is an economically important endemic viral disease of sheep and goats in India, where several different homologous PPR vaccine candidates have been developed. We evaluated the serological response to two vaccine strains, Arasur/87 and Sungri/96, in South Indian cross-bred and native sheep and goats reared under organized and unorganized settings. Animals seronegative (percent inhibition or PI <40) by competitive enzyme-linked immunosorbent assay (c-ELISA) were immunized with either of the vaccine strains or placebo. Sera collected on 21, 60 and 90 days post-vaccination were subjected to c-ELISA and serum neutralization test (SNT). Seropositivity (PI >40), seroconversion (fourfold increase in SNT titres) and seroprotection (SNT titre of ≥8 deemed to be protective) ranged from 66.7 to 84.0 %, 56.0 to 69.2 %, and 60.0 to 76.0 %, respectively. However, no significant difference was observed between responses to the two vaccine strains. These results support the premise that the two vaccine strains are equally efficacious.
authors.affiliation: Department of Veterinary Microbiology, Karnataka Veterinary, Animal and Fisheries Sciences University, Hebbal, Bengaluru, 560024 India.
authors.forename: A K
authors.initials: AK
authors.lastname: Santhosh
authors.affiliation: Institute of Animal Health and Veterinary Biologicals, Hebbal, Bengaluru, 560024 India.
authors.forename: Amitha R
authors.initials: AR
authors.lastname: Gomes
authors.affiliation: Institute of Animal Health and Veterinary Biologicals, Hebbal, Bengaluru, 560024 India.
authors.forename: Raveendra
authors.initials: R
authors.lastname: Hegde
authors.affiliation: Department of Veterinary Microbiology, Karnataka Veterinary, Animal and Fisheries Sciences University, Hebbal, Bengaluru, 560024 India.
authors.forename: D
authors.initials: D
authors.lastname: Rathnamma
authors.affiliation: Department of Veterinary Microbiology, Karnataka Veterinary, Animal and Fisheries Sciences University, Hebbal, Bengaluru, 560024 India.
authors.forename: B M
authors.initials: BM
authors.lastname: Veeregowda
authors.affiliation: Institute of Animal Health and Veterinary Biologicals, Hebbal, Bengaluru, 560024 India.
authors.forename: S M
authors.initials: SM
authors.lastname: Byregowda
authors.affiliation: Institute of Animal Health and Veterinary Biologicals, Hebbal, Bengaluru, 560024 India ; Karnataka Veterinary, Animal and Fisheries Sciences University, Bidar, 585401 India.
authors.forename: C
authors.initials: C
authors.lastname: Renukaprasad
authors.affiliation: Indian Veterinary Research Institute, Hebbal, Bengaluru, 560024 India.
authors.forename: V
authors.initials: V
authors.lastname: Bhanuprakash
authors.affiliation: Project Directorate on Animal Disease Monitoring and Surveillance, Hebbal, Bengaluru, 560024 India.
authors.forename: K
authors.initials: K
authors.lastname: Prabhudas
authors.affiliation: Ella Foundation, Genome Valley, Turkapally, Shameerpet Mandal, Hyderabad, 500078 India.
authors.forename: Nagendra R
authors.initials: NR
authors.lastname: Hegde
authors.affiliation: Department of Veterinary Microbiology, Karnataka Veterinary, Animal and Fisheries Sciences University, Hebbal, Bengaluru, 560024 India.
authors.forename: Shrikrishna
authors.initials: S
authors.lastname: Isloor
keywords: Comparative evaluation; Field testing; Homologous vaccine; Humoral immune response; Peste des petitis ruminants