title: Effect of nanoparticles exposure on fractional exhaled nitric oxide (FENO) in workers exposed to nanomaterials.
abstract: Fractional exhaled nitric oxide (FENO) measurement is a useful diagnostic test of airway inflammation. However, there have been few studies of FENO in workers exposed to nanomaterials. The purpose of this study was to examine the effect of nanoparticle (NP) exposure on FENO and to assess whether the FENO is increased in workers exposed to nanomaterials (NM). In this study, both exposed workers and non-exposed controls were recruited from NM handling plants in Taiwan. A total of 437 subjects (exposed group = 241, non-exposed group = 196) completed the FENO and spirometric measurements from 2009-2011. The authors used a control-banding (CB) matrix to categorize the risk level of each participant. In a multivariate linear regression analysis, this study found a significant association between risk level 2 of NP exposure and FENO. Furthermore, asthma, allergic rhinitis, peak expiratory flow rate (PEFR), and NF-κB were also significantly associated with FENO. When the multivariate logistic regression model was adjusted for confounders, nano-TiO2 in all of the NM exposed categories had a significantly increased risk in FENO > 35 ppb. This study found associations between the risk level of NP exposure and FENO (particularly noteworthy for Nano-TiO2). Monitoring FENO in the lung could open up a window into the role nitric oxide (NO) may play in pathogenesis.
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. ader.una@gmail.com.
authors.forename: Wei-Te
authors.initials: WT
authors.lastname: Wu
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. bobbibrownq@nhri.org.tw.
authors.forename: Hui-Yi
authors.initials: HY
authors.lastname: Liao
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. 010521@nhri.org.tw.
authors.forename: Yu-Teh
authors.initials: YT
authors.lastname: Chung
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. wanfenli@u.washington.edu.
authors.forename: Wan-Fen
authors.initials: WF
authors.lastname: Li
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. tctsou@nhri.org.tw.
authors.forename: Tsui-Chun
authors.initials: TC
authors.lastname: Tsou
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. lihann@nhri.org.tw.
authors.forename: Lih-Ann
authors.initials: LA
authors.lastname: Li
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. mhlin@mail.iosh.gov.tw.
authors.forename: Ming-Hsiu
authors.initials: MH
authors.lastname: Lin
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. hjj@mail.iosh.gov.tw.
authors.forename: Jiune-Jye
authors.initials: JJ
authors.lastname: Ho
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. tnwu@mail.cmu.edu.tw.
authors.forename: Trong-Neng
authors.initials: TN
authors.lastname: Wu
authors.affiliation: Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli 350, Taiwan. shliou@nhri.org.tw.
authors.forename: Saou-Hsing
authors.initials: SH
authors.lastname: Liou
mesh_terms: D000328:Adult; D001249:Asthma / Q000453:epidemiology; D001944:Breath Tests; D045853:Exhalation; D005260:Female; D006801:Humans; D019570:Inhalation Exposure; D008297:Male; D016328:NF-kappa B / Q000032:analysis; D053758:Nanoparticles / Q000633:toxicity*; D009569:Nitric Oxide / Q000032:analysis*; D016273:Occupational Exposure; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000453:epidemiology
chemical_list: D016328:NF-kappa B; D009569:Nitric Oxide