title: New autoantibodies and their clinical associations in juvenile myositis - a systematic review.
abstract: BACKGROUND
  Novel autoantibodies targeting intracellular proteins are recently detected in patients with idiopathic inflammatory myopathies (IIMs).
  
  
  OBJECTIVE
  To evaluate the prevalence of these myositis-specific antibodies (MSAs) in juvenile IIMs (JIIMs) and their association with clinical characteristics and disease course.
  
  
  METHODS
  A systematic literature search was carried out to identify all studies concerning these novel MSAs (p155/140, p140, CADM-140, SAE and 200/100) in patients with JIIMs.
  
  
  RESULTS
  A total of 1003 references were identified, of which 118 were selected for detailed analysis and 13 included in the final review.
  
  
  CONCLUSIONS
  The anti-p155/140, the anti-p140 and the anti-CADM-140 seem to be useful markers for define distinct clinical subsets and for predicting prognosis of JIIMs. Further studies are needed to clarify the importance of anti 200/100 and anti-SAE in juvenile myositis.
authors.forename: Daniela
authors.initials: D
authors.lastname: Peixoto
authors.forename: José
authors.initials: J
authors.lastname: Costa
authors.forename: Marta
authors.initials: M
authors.lastname: Ferretti
authors.forename: Clara
authors.initials: C
authors.lastname: Malattia
authors.forename: Alberto
authors.initials: A
authors.lastname: Martini
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D003882:Dermatomyositis / Q000276:immunology*; D006801:Humans
chemical_list: D001323:Autoantibodies