title: Does abnormal circadian blood pressure pattern really matter in patients with transient ischemic attack or minor stroke?
abstract: OBJECTIVE
  Patients with stroke are more likely to have impaired autonomic nervous function and abnormal circadian blood pressure (BP) patterns. It remains unclear whether circadian BP patterns in patients with transient ischemic attack or minor stroke (National Institutes of Health Stroke Scale ≤3) differ from those in the normal population.
  
  
  METHODS
  Participants were assessed using a 24-hour ambulatory BP monitor and a short-term measurement of heart rate variability.
  
  
  RESULTS
  There were 76 patients (mean age, 67.2 years; 57.9% men; and 61.8% transient ischemic attack) and 82 controls (65.6 years; 54.9% men). A history of hypertension was more prevalent in patients (72.4%; controls 48.8%). Circadian BP patterns were distributed similarly among patients and controls, and heart rate variability was also consistent between patients and controls.
  
  
  CONCLUSIONS
  In contrast to previous findings among patients with acute stroke, patients with transient ischemic attack or minor stroke had similar BP patterns and autonomic nervous system function, when compared with controls.
authors.affiliation: From the Florey Institute of Neuroscience and Mental Health, Melbourne, Australia (W.Z., D.A.C., L.C., G.A.D., H.M.D.); Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia (D.A.C., L.C., G.A.D., C.O'C., H.M.D.); Translational Public Health Research Unit, Stroke and Ageing Research, Southern Clinical School, Monash University, Melbourne, Victoria, Australia (D.A.C.); Neurology Department, Austin Hospital, Heidelberg, Victoria, Australia (H.M.D.); Clinical Pharmacology, Austin Health, Heidelberg, Victoria, Australia (C.O'C.); and Austin Health, Heidelberg, Victoria, Australia (W.Z.).
authors.forename: WenWen
authors.initials: W
authors.lastname: Zhang
authors.forename: Dominique A
authors.initials: DA
authors.lastname: Cadilhac
authors.forename: Leonid
authors.initials: L
authors.lastname: Churilov
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Donnan
authors.forename: Christopher
authors.initials: C
authors.lastname: O'Callaghan
authors.forename: Helen M
authors.initials: HM
authors.lastname: Dewey
mesh_terms: D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D002546:Ischemic Attack, Transient / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D018401:Sample Size; D012907:Smoking / Q000009:adverse effects; D020521:Stroke / Q000503:physiopathology*
keywords: ambulatory blood pressure monitoring; autonomic nervous system; ischemic attack, transient