title: A comparison study of haemolysis production in three contemporary centrifugal pumps.
abstract: One challenge in providing extracorporeal circulation is to supply optimal flow while minimising adverse effects, such as haemolysis. To determine if the recent generation constrained vortex pumps with their inherent design improvements would lead to reduced red cell trauma, we undertook a study comparing three devices. Utilizing a simulated short-term ventricular assist circuit primed with whole human blood, we examined changes in plasma free haemoglobin values over a six-day period. The three pumps investigated were the Maquet Rotaflow, the Levitronix PediVAS and the Medos Deltastream DP3.This study demonstrated that all three pumps produced low levels of haemolysis and are suitable for use in a clinical environment. The Levitronix PediVAS was significantly less haemolytic than either the Rotaflow (p<0.05) or the DP3 (p<0.05). There was no significant difference in plasma free haemoglobin between the Rotaflow and the DP3 (p=0.71).
authors.affiliation: Perfusion Department, Royal Children's Hospital, Melbourne, Victoria, Australia steve.bottrell@rch.org.au.
authors.forename: S
authors.initials: S
authors.lastname: Bottrell
authors.affiliation: Perfusion Department, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Bennett
authors.affiliation: Perfusion Department, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Augustin
authors.affiliation: Perfusion Department, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: C
authors.initials: C
authors.lastname: Thuys
authors.affiliation: Perfusion Department, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: B
authors.initials: B
authors.lastname: Schultz
authors.affiliation: Perfusion Department, Royal Children's Hospital, Melbourne, Victoria, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Horton
authors.affiliation: Perfusion Department, Royal Children's Hospital, Melbourne, Victoria, Australia Department of Paediatrics, Melbourne University, Melbourne, Victoria, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Horton
mesh_terms: D005112:Extracorporeal Circulation / Q000295:instrumentation*; D005260:Female; D006353:Heart-Assist Devices; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D008297:Male
chemical_list: D006454:Hemoglobins
keywords: ECLS; ECMO; VAD; centrifugal pump; diagonal pump; haemolysis; hybrid pump