title: Aortic arch calcification detectable on chest X-ray films is associated with plasma diacron-reactive oxygen metabolites in patients with type 2 diabetes but without cardiovascular disease.
abstract: OBJECTIVE
  This study aimed to evaluate the relationship between aortic arch calcification (AAC) detectable on chest X-ray films and plasma diacron-reactive oxygen metabolites (d-ROMs) in patients with type 2 diabetes but without cardiovascular disease.
  
  
  METHODS
  Forty-nine patients with type 2 diabetes but without cardiovascular disease were evaluated with chest X-ray examinations and divided into those with AAC (n=26) and those without AAC (n=23). Biochemical variables, including plasma levels of d-ROMS, high-sensitivity C-reactive protein (hsCRP), plasminogen activator inhibitor-1 (PAI-1), and lipoprotein(a) (Lp(a)), were evaluated after an overnight fast. The relationships of AAC with both inflammation and oxidative-stress variables were evaluated.
  
  
  RESULTS
  The plasma level of d-ROMs in subjects with AAC was significantly higher than that in subjects without AAC, whereas plasma levels of hsCRP, PAI-1, and Lp(a) in subjects with AAC were higher, but not significantly so, than those in subjects without AAC. Multivariate linear regression analysis with AAC grade as the dependent variable and plasma levels of d-ROMs, hsCRP, PAI-1, or Lp(a) as independent variables demonstrated a significant association of AAC grade with plasma levels of d-ROMs but not with plasma levels of hsCRP, PAI-1, or Lp(a).
  
  
  CONCLUSIONS
  The plasma level of d-ROMs is associated with AAC in patients with type 2 diabetes but without cardiovascular disease. Hence, the results of the present study suggest that AAC in these patients is strongly associated with oxidative stress. Furthermore, patients with type 2 diabetes and AAC may be at high risk for the development and progression of various diabetic complications induced by oxidative stress.
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University Faculty of Medicine.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohara
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Suzuki
authors.forename: Motoshi
authors.initials: M
authors.lastname: Ouchi
authors.forename: Kazunari
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masao
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Taro
authors.initials: T
authors.lastname: Saigusa
authors.forename: Junya
authors.initials: J
authors.lastname: Aoyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Kenzo
authors.initials: K
authors.lastname: Oba
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood / Q000473:pathology; D001013:Aorta, Thoracic / Q000000981:diagnostic imaging* / Q000473:pathology; D002114:Calcinosis / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000473:pathology; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D018384:Oxidative Stress; D013902:Radiography, Thoracic; D017382:Reactive Oxygen Species / Q000097:blood*; D013997:Time Factors
chemical_list: D017382:Reactive Oxygen Species