title: [A case of appearance of a prominent rash in response to alternate-day S-1 administration as adjuvant chemotherapy for lower gingival cancer].
abstract: We report the development of a prominent rash in response to alternate-day S-1 administration in a patient with oral cancer. The patient was a 75-year-old woman with left-side lower gingival cancer(T4N1M0). After chemoradiotherapy, the patient underwent radical surgery. She was treated with oral S-1, administered on alternate days at a dosage of 80mg/day (orally, twice per day), as postoperative adjuvant chemotherapy. Edematous erythema, accompanied by strong itching and paraesthesia, appeared focally on the face and the limbs 1 month after beginning S-1 treatment. Since the rash was determined to be drug-induced, S-1 administration was stopped, and steroid, antihistamine, and topical steroid treatment was initiated. The symptoms gradually improved, and the rash disappeared without recurrence approximately 1 month later. Although alternate-day administration is considered to be a safe and effective method to administer S-1 oral therapy, it should be noted that cutaneous symptoms might appear after a fixed dosage is exceeded.
authors.affiliation: Dept. of Oral and Maxillofacial Surgery, Saga Medical School.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Yukishi
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Goto
mesh_terms: D000368:Aged; D059248:Chemoradiotherapy; D017024:Chemotherapy, Adjuvant; D004338:Drug Combinations; D005076:Exanthema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005887:Gingival Neoplasms / Q000628:therapy*; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D010094:Oxonic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D013256:Steroids / Q000627:therapeutic use; D005641:Tegafur / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D006633:Histamine Antagonists; D013256:Steroids; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid