title: EPCR: holy grail of malaria cytoadhesion?
abstract: In this issue of Blood, Aird et al review recent findings that suggest the endothelial protein C receptor (EPCR), known for its pivotal role in mediating cytoprotection against coagulopathy, proinflammatory cytokines, and vascular permeability, may serve as a receptor for Plasmodium falciparum-infected red blood cells (IRBCs) in the brain. In the process, coagulation is allowed to proceed unchecked and contributes to the pathogenesis of cerebral malaria.
authors.affiliation: UNIVERSITY OF CALGARY.
authors.forename: May
authors.initials: M
authors.lastname: Ho
mesh_terms: D015703:Antigens, CD / Q000378:metabolism*; D000074283:Endothelial Protein C Receptor; D004912:Erythrocytes / Q000378:metabolism* / Q000469:parasitology*; D006801:Humans; D016779:Malaria, Cerebral / Q000378:metabolism*; D016778:Malaria, Falciparum / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D011956:Receptors, Cell Surface