title: Study on the variation rules of the joint effects for multicomponent mixtures containing cyanogenic toxicants and aldehydes based on the transition state theory.
abstract: Although the study of the variation rules of the joint effects for multicomponent mixtures has gained increasing attention, it still remains unclear how the variation occurs and what the relationships between the joint effects of multicomponent mixtures and their corresponding binary mixtures are. To explain how the variation occurs, this study first proposes a hypothesis on the variation rules of the joint effects using the well-known transition state theory. The hypothesis concluded that the joint effect of multicomponent mixtures is among the joint effects of the corresponding binary mixtures. This hypothesis was named the fishing hypothesis because there is a similarity between the action process of the joint effects and the fishing process. Next, the hypothesis was validated by use of the experimental data by evaluating the joint effects of binary, ternary and quaternary mixtures containing cyanogenic toxicants and aldehydes on Photobacterium phosphoreum. The application of the fishing hypothesis can explain the rule as to how the joint effects of a multicomponent-mixture vary with its number of components and their ratios. This study provides a good method to predict the joint effects of multicomponent mixtures using the joint effects of their corresponding binary mixtures. An improvement in the fishing hypothesis will be needed in our future studies due to the approximate assumptions used in the deduction of the hypothesis.
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.
authors.forename: Weiying
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Chemical and Environmental Engineering, Anyang Institute of Technology, Anyang 455000, China.
authors.forename: Dayong
authors.initials: D
authors.lastname: Tian
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Collaborative Innovation Center for Regional Environmental Quality, China. Electronic address: lzhifen@tongji.edu.cn.
authors.forename: Zhifen
authors.initials: Z
authors.lastname: Lin
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.
authors.forename: Dali
authors.initials: D
authors.lastname: Wang
authors.affiliation: Collaborative Innovation Center for Regional Environmental Quality, China; School of the Environment, State Key Laboratory of Pollution Control and Resources Reuse, Nanjing University, Nanjing 210093, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Yu
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000633:toxicity*; D000465:Algorithms; D045424:Complex Mixtures / Q000737:chemistry* / Q000633:toxicity*; D004735:Energy Transfer; D015386:Hazardous Substances / Q000737:chemistry* / Q000633:toxicity*; D007700:Kinetics; D049449:Luminescence; D008956:Models, Chemical; D009570:Nitriles / Q000737:chemistry* / Q000633:toxicity*; D016011:Normal Distribution; D010776:Photobacterium; D044366:Transition Temperature
chemical_list: D000447:Aldehydes; D045424:Complex Mixtures; D015386:Hazardous Substances; D009570:Nitriles; C011206:cyanogen; C000945:dicyanmethane
keywords: Fishing hypothesis; Joint effects; Multicomponent mixture; Reactive chemicals; Transition state