title: Dynamics of soft nanomaterials captured by transmission electron microscopy in liquid water.
abstract: In this paper we present in situ transmission electron microscopy of synthetic polymeric nanoparticles with emphasis on capturing motion in a solvated, aqueous state. The nanoparticles studied were obtained from the direct polymerization of a Pt(II)-containing monomer. The resulting structures provided sufficient contrast for facile imaging in situ. We contend that this technique will quickly become essential in the characterization of analogous systems, especially where dynamics are of interest in the solvated state. We describe the preparation of the synthetic micellar nanoparticles together with their characterization and motion in liquid water with comparison to conventional electron microscopy analyses.
authors.affiliation: Department of Chemistry & Biochemistry and ⊥Moores Cancer Center, University of California, San Diego , La Jolla, California 92093, United States.
authors.forename: Maria T
authors.initials: MT
authors.lastname: Proetto
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Rush
authors.forename: Miao-Ping
authors.initials: MP
authors.lastname: Chien
authors.forename: Patricia
authors.initials: P
authors.lastname: Abellan Baeza
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Patterson
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Thompson
authors.forename: Norman H
authors.initials: NH
authors.lastname: Olson
authors.forename: Curtis E
authors.initials: CE
authors.lastname: Moore
authors.forename: Arnold L
authors.initials: AL
authors.lastname: Rheingold
authors.forename: Christopher
authors.initials: C
authors.lastname: Andolina
authors.forename: Jill
authors.initials: J
authors.lastname: Millstone
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Howell
authors.forename: Nigel D
authors.initials: ND
authors.lastname: Browning
authors.forename: James E
authors.initials: JE
authors.lastname: Evans
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Gianneschi
mesh_terms: D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties; D013816:Thermodynamics; D014867:Water / Q000737:chemistry*
chemical_list: D011108:Polymers; D014867:Water