title: Pulse in pulse intense pulsed light for melasma treatment: a pilot study.
abstract: BACKGROUND
  A new type of intense pulsed light IPL with pulse-in-pulse (PIP) mode (multiple fractionated subpulses in one pulse width) has recently been developed.
  
  
  OBJECTIVE
  To evaluate the clinical efficacy and safety of PIP IPL in patients with melasma.
  
  
  METHODS
  Half of each patient's face was treated with IPL and six treatment sessions with a low-fluence quality-switched neodymium-doped yttrium aluminum garnet laser (IPL/T) every 2 weeks. The other half was treated with PIP IPL. Outcome assessments included photography, modified Melasma Area and Severity Index (MASI) score, and patient satisfaction. The melanin and erythema indices were used for objective evaluation. Patients were followed up for 6 months after the last treatment.
  
  
  RESULTS
  All patients completed the study successfully. On both treated sides, the melanin index decreased significantly after treatment. The modified MASI score also fell 54.4% on the PIP IPL side and 50.0% on the IPL/T side. No patients reported serious aggravation of melasma for 6 months after the last treatment. Patients favored PIP IPL due to less discomfort during and after treatments.
  
  
  CONCLUSIONS
  PIP IPL may be a safe and promising treatment for melasma.
authors.affiliation: Department of Dermatology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea.
authors.forename: Jong Yoon
authors.initials: JY
authors.lastname: Chung
authors.forename: Mira
authors.initials: M
authors.lastname: Choi
authors.forename: Jae Hyung
authors.initials: JH
authors.lastname: Lee
authors.forename: Soyun
authors.initials: S
authors.lastname: Cho
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D062325:Intense Pulsed Light Therapy / Q000379:methods*; D008548:Melanosis / Q000628:therapy*; D017060:Patient Satisfaction; D010865:Pilot Projects; D012720:Severity of Illness Index; D016896:Treatment Outcome