title: Highly enantioselective organocatalytic α-sulfenylation of azlactones.
abstract: The first asymmetric α-sulfenylation of azlactones with N-(sulfanyl)succinimides has been developed by using cinchona alkaloid-derived squaramide as a catalyst and 4 Å molecular sieves as an additive. The reaction conditions were suitable to 4-alkyl and benzyl-substituted azlactones as well as N-(benzyl/alkyl/arylthio)succinimides, affording adducts with high enantioselectivities (81-94% ee).
authors.affiliation: Institute of Chemical Biology and ‡Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University , Kaifeng, Henan, China , 475004.
authors.forename: Baokun
authors.initials: B
authors.lastname: Qiao
authors.forename: Xinfei
authors.initials: X
authors.lastname: Liu
authors.forename: Shaobo
authors.initials: S
authors.lastname: Duan
authors.forename: Lin
authors.initials: L
authors.lastname: Yan
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D002384:Catalysis; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013388:Succinimides / Q000737:chemistry*; D013416:Sulfamerazine / Q000737:chemistry*
chemical_list: D007783:Lactones; D013388:Succinimides; D013416:Sulfamerazine