title: Solution NMR assignment of the heavy chain complex of the human cardiac myosin regulatory light chain.
abstract: The regulatory light chain (RLC) of striated and cardiac muscle myosin plays a complex role in muscle function and regulation. Together with the essential light chain it provides stability to the lever arm, which is essential for force generation. Furthermore, phosphorylation and interaction with myosin binding protein C (MyBP-C) suggest an additional role in the regulation of muscle contraction. The former is of particular importance in the heart, where RLC phosphorylation appears to be correlated to the wringing motion of heart contraction. To address these questions and because of a lack of mammalian RLC structures, we initiated an NMR study of the human cardiac regulatory myosin light chain.
authors.affiliation: Cardiovascular and Randall Division, King's College London, Guy's Campus, London, SE1 1UL, UK.
authors.forename: Elena
authors.initials: E
authors.lastname: Rostkova
authors.forename: Mathias
authors.initials: M
authors.lastname: Gautel
authors.forename: Mark
authors.initials: M
authors.lastname: Pfuhl
mesh_terms: D006801:Humans; D018994:Myosin Light Chains / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012996:Solutions
chemical_list: D018994:Myosin Light Chains; D012996:Solutions