title: Myrifabine, the first dimeric Myrioneuron alkaloid from Myrioneuron faberi.
abstract: One Myrioneuron alkaloid, myrifabine (1), the first example of a dimer with 12 chiral centers embraced in a decacyclic novel skeleton, was isolated from Myrioneuron faberi . Its structure was elucidated by spectroscopic data and single-crystal X-ray diffraction. The antimicrobial and cytotoxic activities of 1 were evaluated in vitro.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, PR China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Cao
authors.forename: Sheng-Dian
authors.initials: SD
authors.lastname: Huang
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Chun-Mao
authors.initials: CM
authors.lastname: Yuan
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Zuo
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Gu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D019666:Rubiaceae / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; C000589996:myrifabine; D014640:Vancomycin