title: The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness: a randomized, double-blind, placebo-controlled trial.
abstract: The purpose of the study was to evaluate the effects of Lactobacillus pentosus strain b240 (b240) intake and appropriate physical training on salivary secretory immunoglobulin A secretion in elderly adults with low physical fitness. Elderly adults with low physical fitness (daily step count below 3,500 steps) were divided into 2 groups: a b240 intake + exercise group (b240 group) and a placebo intake + exercise group (placebo group). Each subject continued intake of b240 or placebo and moderate-intensity resistance exercise for 12 weeks. Before and 4, 8, and 12 weeks after the start of intervention, each subject underwent saliva sampling. Before and after intervention, physical fitness tests and step count were measured. Our results showed that secretory immunoglobulin A secretion in 57 subjects during the b240/placebo intake period was significantly greater in the b240 group than in the placebo group (p<0.05). There were no significant changes in physical fitness tests before and after intervention in the 2 groups. The daily amount of walking increased significantly after intervention in both groups (p<0.05). These results suggest that in elderly adults with low physical activity and fitness, intake of b240 with appropriate physical exercise elevate salivary secretory immunoglobulin A secretion.
authors.affiliation: Sports Research & Development Core, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shimizu
authors.affiliation: Research & Development Department, Tsukuba Wellness Research Co., Ltd., D6 Block 8 Kenkyu-gakuen, Tsukuba, Ibaraki 305-0817, Japan.
authors.forename: Hironori
authors.initials: H
authors.lastname: Sato
authors.affiliation: Research & Development Department, Tsukuba Wellness Research Co., Ltd., D6 Block 8 Kenkyu-gakuen, Tsukuba, Ibaraki 305-0817, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Suga
authors.affiliation: Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, 3-31-13 Saigawa, Otsu, Shiga 520-0002, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Yamahira
authors.affiliation: Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, 3-31-13 Saigawa, Otsu, Shiga 520-0002, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Toba
authors.affiliation: Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, 3-31-13 Saigawa, Otsu, Shiga 520-0002, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Hamuro
authors.affiliation: Information Management Office, Drug Safety Research Center, Tokushima Research Institute, Otsuka Pharmaceutical, Co., Ltd., 463-10 Kawauchi-cho, Tokushima 771-0130, Japan.
authors.forename: Keiji
authors.initials: K
authors.lastname: Kakumoto
authors.affiliation: Otsu Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, 3-31-13 Saigawa, Otsu, Shiga 520-0002, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kohda
authors.affiliation: Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa, Saitama 359-1192, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Akama
authors.affiliation: Graduate School of Comprehensive Human Sciences, Doctoral Program of Sports Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kono
authors.affiliation: Graduate School of Comprehensive Human Sciences, Doctoral Program of Sports Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Kuno
keywords: Lactobacillus pentosus; elderly; low physical fitness; mucosal immunity; salivary SIgA