title: Could cellular proliferation be a predictive index for the relapse of nasal polyposis and down-regulated by nasal steroid treatment?
abstract: The aim of this article is to identify the cellular mitotic activity using Ki-67 monoclonal antibody for predicting relapses of nasal polyposis after surgery. A prospective study was conducted at Kartal Training and Research Hospital Otolaryngology Department between January 2006 and September 2008. Nasal polyps were obtained from all patients and pathological materials were analyzed for the Ki-67 staining using immunohistochemistry. Patients were followed after surgery for 12 months for relapse. There was no statistically significant difference between recurrent and nonrecurrent polyps. Polyp recurrence has a multifactorial origin. Ki-67 index alone does not provide sufficient information about polyp recurrence before the operation.
authors.affiliation: Department of Otorhinolaryngology, Gebze Government Hospital, Istanbul, Turkey.
authors.forename: Ilter
authors.initials: I
authors.lastname: Tezer
authors.affiliation: Department of Otorhinolaryngology, Faculty of Medicine, Rize University, Rize, Turkey ; KBB AD., Rize Üniversitesi Tıp Fakültesi, İslampaşa Mah., Merkez/Rize , 53100 Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Celebi Erdivanli
authors.affiliation: Dr.Lutfi Kirdar Kartal Training and Research Hospital 2 nd ENT Department, Istanbul, Turkey.
authors.forename: Arif
authors.initials: A
authors.lastname: Sanli
authors.affiliation: Dr.Lutfi Kirdar Kartal Training and Research Hospital 2 nd ENT Department, Istanbul, Turkey.
authors.forename: Sedat
authors.initials: S
authors.lastname: Aydin
keywords: Cellular proliferation; Nasal polyposis; Nasal steroid treatment