title: Influence of Acanthamoeba genotype on clinical course and outcomes for patients with Acanthamoeba keratitis in Spain.
abstract: Genotype T4 is by far the most frequent genotype of Acanthamoeba keratitis (AK) and therefore has been considered the most virulent. This study included 14 cases of AK of genotype T4 and three cases of non-T4 genotype. We found that cases of non-T4 genotype had a worse response to medical therapy, greater need for surgical intervention, greater risk of extracorneal involvement, and remarkably poorer final visual outcome than those of T4 genotype, suggesting an association between Acanthamoeba virulence and genotype that requires additional case investigation.
authors.affiliation: Cornea Unit, Ophthalmology Department, IRYCIS, Ramón y Cajal Hospital, Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Arnalich-Montiel
authors.forename: Blanca
authors.initials: B
authors.lastname: Lumbreras-Fernández
authors.forename: Carmen M
authors.initials: CM
authors.lastname: Martín-Navarro
authors.forename: Basilio
authors.initials: B
authors.lastname: Valladares
authors.forename: Rogelio
authors.initials: R
authors.lastname: Lopez-Velez
authors.forename: Rafael
authors.initials: R
authors.lastname: Morcillo-Laiz
authors.forename: Jacob
authors.initials: J
authors.lastname: Lorenzo-Morales
mesh_terms: D000048:Acanthamoeba / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D015823:Acanthamoeba Keratitis / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology* / Q000628:therapy; D000293:Adolescent; D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain / Q000453:epidemiology; D016896:Treatment Outcome; D014774:Virulence; D055815:Young Adult