title: Cracking the survival code: autophagy-related histone modifications.
abstract: Modifications of histones, the chief protein components of the chromatin, have emerged as critical regulators of life and death. While the "apoptotic histone code" came to light a few years ago, accumulating evidence indicates that autophagy, a cell survival pathway, is also heavily regulated by histone-modifying proteins. In this review we describe the emerging "autophagic histone code" and the role of histone modifications in the cellular life vs. death decision.
authors.affiliation: Department of Oncology Pathology; Cancer Centrum Karolinska; Karolinska Institutet; Stockholm, Sweden.
authors.forename: Jens
authors.initials: J
authors.lastname: Füllgrabe
authors.affiliation: Department of Laboratory Medicine; Karolinska Institutet; Huddinge, Sweden.
authors.forename: Nina
authors.initials: N
authors.lastname: Heldring
authors.affiliation: Department of Neuroscience; Karolinska Institutet; Stockholm, Sweden.
authors.forename: Ola
authors.initials: O
authors.lastname: Hermanson
authors.affiliation: Department of Oncology Pathology; Cancer Centrum Karolinska; Karolinska Institutet; Stockholm, Sweden.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Joseph
mesh_terms: D000107:Acetylation; D000818:Animals; D001343:Autophagy / Q000235:genetics* / Q000502:physiology; D016923:Cell Death / Q000235:genetics; D002470:Cell Survival / Q000235:genetics; D002843:Chromatin / Q000235:genetics*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000235:genetics*
chemical_list: D002843:Chromatin; D006657:Histones
keywords: EHMT2/G9a; HAT; HDAC; HDM; HMT; KAT8/hMOF/MYST1; SUV420H2; histone code; histone posttranslational modifications