title: A small switch has a large effect on autophagy.
abstract: Atg8 family proteins and Atg13 are important regulators of autophagy. In this issue of Structure, Suzuki and colleagues describe crystal structures of light chain 3 (LC3; Atg8) in complex with the Atg13 LC3 interacting region (LIR) motif and identify a subtle switch of side chain conformation regulating the LC3-LIR interaction and autophagosome formation in vivo.
authors.affiliation: University Grenoble Alpes, 38000 Grenoble, France; CNRS, UVHCI, 38000 Grenoble, France; Unit of Virus Host-Cell Interactions, University Grenoble Alpes-EMBL-CNRS, 6 rue Jules Horowitz, 38042 Grenoble, France. Electronic address: weissenhorn@embl.fr.
authors.forename: Winfried
authors.initials: W
authors.lastname: Weissenhorn
authors.affiliation: University Grenoble Alpes, 38000 Grenoble, France; INSERM, U1038, 38054 Grenoble, France; CEA, DSV, iRTSV, BGE, Gen&Chem, 38054 Grenoble, France. Electronic address: mofauvarque@cea.fr.
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Fauvarque
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry*; D000818:Animals; D001343:Autophagy / Q000235:genetics*; D000071183:Autophagy-Related Proteins; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000737:chemistry*; D010588:Phagosomes / Q000235:genetics*
chemical_list: C534291:ATG13 protein, human; D048868:Adaptor Proteins, Signal Transducing; D000071183:Autophagy-Related Proteins; C477012:MAP1LC3A protein, human; C502070:MAP1LC3B protein, human; D008869:Microtubule-Associated Proteins