title: Methyl palmitate attenuates lipopolysaccharide-induced acute lung injury in mice.
abstract: OBJECTIVE
  The study is aimed to determine the beneficial effects of methyl palmitate (MP) which has antioxidant and anti-inflammatory effects demonstrated on murine model of acute lung injury induced by lipopolysaccharide (LPS).
  
  
  METHODS
  Forty male BALB/C mice were randomly allocated into four groups (n=10, each): control group, methyl palmitate group (300 mg/kg), LPS group, and methyl palmitate -treated groups. Methyl palmitate or vehicle was given with an intraperitoneal administration 1 h before an intratracheal instillation of LPS (5 mg/kg). The severity of pulmonary injury was evaluated 6 h after LPS challenge. All experimental procedures complied with the requirements of the Animal Care and Ethics Committee of the Adnan Menderes University.
  
  
  RESULTS
  Methyl palmitate pretreatment significantly attenuated LPS-induced pulmonary histopathologic changes, alveolar hemorrhage, and neutrophil infiltration. Methyl palmitate pretreatment also reduced the concentrations of malondialdehyde in lung tissues.
  
  
  CONCLUSIONS
  This study indicates that methyl palmitate may have a protective effect against LPS-induced acute lung injury, and the potential mechanism of this action may involve the inhibition of NF-κB. activation.
authors.affiliation: Departments of Chest Diseases, Faculty of Medicine Mugla University, Mugla, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Kalemci
authors.forename: A
authors.initials: A
authors.lastname: Zeybek
authors.forename: Y S
authors.initials: YS
authors.lastname: Intepe
authors.forename: A G
authors.initials: AG
authors.lastname: Uner
authors.forename: T
authors.initials: T
authors.lastname: Acar
authors.forename: A
authors.initials: A
authors.lastname: Yaylali
authors.forename: S
authors.initials: S
authors.lastname: Aksun
authors.forename: C
authors.initials: C
authors.lastname: Can
authors.forename: A
authors.initials: A
authors.lastname: Gulaydin
authors.forename: R
authors.initials: R
authors.lastname: Sütçü
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D008070:Lipopolysaccharides; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D010168:Palmitates / Q000627:therapeutic use*
chemical_list: D008070:Lipopolysaccharides; D016328:NF-kappa B; D010168:Palmitates; C019012:methyl palmitate