title: Management of sinonasal tumors: prognostic factors and outcomes: a 10 year experience at a tertiary care hospital.
abstract: Sinonasal malignancies are said to be a highly heterogeneous group of cancers, accounting for less than 1 % of all cancers and less than 3 % of all upper aerodigestive tract tumors. Originating from any histologic components of the sinonasal cavity, the histopathology of these tumors is diverse. Accordingly, treatment options vary, surgery being the mainstay in most of them. Recurrence rates differs with each histological type of tumor, dependent on various factors. In this article, we have tried to identify the prevalent characteristics of sinonasal malignancies and to outline the prognostic factors affecting the outcome. It is a retrospective study design with a total number of 102 patients. Patients diagnosed with sinonasal malignancies were included and any patient previously operated outside our institute or having received prior radiation or chemotherapy were excluded. The patients were selected over a period of 10 years, from 2000 to 2010. Data was analyzed using SPSS 17. Majority of the sinonasal tumors were squamous cell carcinomas involving the maxillary sinus. Locoregional recurrence was found to be more frequent in patients with positive neck nodes on final histopathology. Sinonasal malignancies are mostly squamous cell in variety and recurrence of these rare entities is dependent on the histological variety and the presence of positive neck nodes.
authors.affiliation: Head and Neck Surgery, Department of Oto-rhinolaryngology, Aga Khan University Hospital, Karachi, 75500 Pakistan ; Aga Khan University Hospital, Stadium Road, Karachi, 74800 Pakistan.
authors.forename: Maliha
authors.initials: M
authors.lastname: Kazi
authors.affiliation: Head and Neck Surgery, Department of Oto-rhinolaryngology, Aga Khan University Hospital, Karachi, 75500 Pakistan.
authors.forename: Sohail
authors.initials: S
authors.lastname: Awan
authors.affiliation: Head and Neck Surgery, Department of Oto-rhinolaryngology, Jinnah Medical and Dental College, Karachi, Pakistan.
authors.forename: Montasir
authors.initials: M
authors.lastname: Junaid
authors.affiliation: Head and Neck Surgery, Department of Oto-rhinolaryngology, Aga Khan University Hospital, Karachi, 75500 Pakistan.
authors.forename: Sadaf
authors.initials: S
authors.lastname: Qadeer
authors.affiliation: Head and Neck Surgery, Department of Oto-rhinolaryngology, Aga Khan University Hospital, Karachi, 75500 Pakistan.
authors.forename: Nabeel Humayun
authors.initials: NH
authors.lastname: Hassan
keywords: Locoregional recurrence; Positive neck nodes; Sinonasal malignancy; Squamous cell carcinoma