title: Pore-forming compounds as signal transduction elements for highly sensitive biosensing.
abstract: Pore-forming compounds are attracting much attention due to the signal transduction ability for the development of highly sensitive biosensing. In this review, we describe an overview of the recent advances made by our group in the design of molecular sensing interfaces of spherical and planar lipid bilayers and natural bilayers. The potential uses of pore-forming compounds, such as gramicidin and MCM-41, in lipid bilayers and natural glutamate receptor channels in biomembrane are presented.
authors.affiliation: Department of Chemistry, College of Humanities and Sciences, Nihon University.
authors.forename: Masao
authors.initials: M
authors.lastname: Sugawara
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shoji
authors.forename: Misato
authors.initials: M
authors.lastname: Sakamoto
mesh_terms: D015374:Biosensing Techniques; D006096:Gramicidin / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D012822:Silicon Dioxide / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008051:Lipid Bilayers; C509968:MCM-41; D006096:Gramicidin; D012822:Silicon Dioxide