title: Circadian rhythm of serum cortisol in female patients with fibromyalgia syndrome.
abstract: Fibromyalgia syndrome (FMS) patients have disturbed sleep patterns which may lead to altered circadian rhythm in serum cortisol secretion. The aim of this study was to assess circadian changes, if any, in serum cortisol levels in female patients with FMS. Cortisol levels were estimated every 6 h during 24 h period; in 40 female patients satisfying ACR criteria for FMS (Age 36.4 ± 9.9), and 40 healthy females without FMS (Age 33.8 ± 11.1). A significant difference in the night time serum cortisol level was observed among the patients and control groups (patients, 12.9 ± 9.7 controls 5.8 ± 3.0; p < 0.01). However, no significant difference was found in serum cortisol levels in patients and control groups in the morning (patients, 28.4 ± 13.2 controls, 27.6 ± 14.5; p > 0.05), afternoon (patients, 14.4 ± 5.6 controls, 14.0 ± 6.6; p > 0.05) and evening hours (patients, 10.9 ± 5.8 controls, 8.9 ± 3.6; p > 0.05). It could be concluded that there is an abnormality in circadian secretion of cortisol in female FMS patients.
authors.affiliation: Department of Rheumatology, King George's Medical University, Lucknow, 226003 UP India.
authors.forename: Ghizal
authors.initials: G
authors.lastname: Fatima
authors.affiliation: Department of Rheumatology, King George's Medical University, Lucknow, 226003 UP India.
authors.forename: Siddharth Kumar
authors.initials: SK
authors.lastname: Das
authors.affiliation: Medical Elementology and Free Radical Biology Lab, Department of Biochemistry, King George's Medical University, Lucknow, 226003 UP India.
authors.forename: Abbas Ali
authors.initials: AA
authors.lastname: Mahdi
authors.affiliation: Department of Physiology, King George's Medical University, Lucknow, 226003 UP India.
authors.forename: Nar Singh
authors.initials: NS
authors.lastname: Verma
authors.affiliation: Department of Zoology, Lucknow University, Lucknow, 226003 UP India.
authors.forename: Faizan Haider
authors.initials: FH
authors.lastname: Khan
authors.affiliation: Department of Biochemistry, King George's Medical University, Lucknow, 226003 UP India.
authors.forename: Amit Mani Kumar
authors.initials: AM
authors.lastname: Tiwari
authors.affiliation: Department of Biochemistry, King George's Medical University, Lucknow, 226003 UP India.
authors.forename: Tabrez
authors.initials: T
authors.lastname: Jafer
authors.affiliation: Department of Biochemistry, King George's Medical University, Lucknow, 226003 UP India.
authors.forename: Baby
authors.initials: B
authors.lastname: Anjum
keywords: American College of Rheumatology Criteria; Circadian rhythm; Cortisol; Fibromyalgia syndrome