title: An unusual presentation of medullary thyroid carcinoma.
abstract: Medullary thyroid carcinoma (MTC) is extremely uncommon having varied presentations & their prognosis is not exactly known; but as MTC is an aggressive tumor hence it needs to be documented in literature to help to know the behaviour of this variant. We report a rare presentation of medullary carcinoma of thyroid in a 48 years old man who presented with huge swelling at left side of neck extending from parotid to supraclavicular region with normal-sized thyroid gland of long duration. FNAC & incision HPE of this swelling was inconclusive so we had operated this swelling. Immunohistochemistry reported it as metastatic Medullary carcinoma of thyroid; tumor cells express Cytokeratin, Calcitonin, EMA, Synaptophysin, Chromogranin-A. The stroma shows deposits of Amyloid, which have been confirmed by Congo red staining. Post-operatively FNAC from thyroid gland supported the diagnosis of Medullary carcinoma. Post-operatively the residual mass was regressed with chemotherapy & radiotherapy. The calcitonin level also decreased following this treatment. There was no recurrence at 11 months but ultimately patient died with metastasis.
authors.affiliation: Department of Otorhinolaryngology, BSMC & H, Bankura, 722102 India ; 8, Manik Bandhyopadhyay sarani, Kolkata, 700040 India.
authors.forename: Sudip Kr
authors.initials: SK
authors.lastname: Das
authors.affiliation: Department of Otorhinolaryngology, Institute of Postgraduate Medical Education & Research (IPGME&R), 244B, Acharya J. C. Bose Road, Kolkata, 700020 India.
authors.forename: Himanshu
authors.initials: H
authors.lastname: Varshney
authors.affiliation: Department of Surgery, Institute of Postgraduate Medical Education & Research (IPGME&R), 244B, Acharya J. C. Bose Road, Kolkata, 700020 India.
authors.forename: M L
authors.initials: ML
authors.lastname: Saha
authors.affiliation: Department of Otorhinolaryngology, BSMC & H, Bankura, 722102 India.
authors.forename: Shubhrakanti
authors.initials: S
authors.lastname: Sen
authors.affiliation: RMO cum Clinical tutor MMC, Medinipur, 721101 India.
authors.forename: Amit Bikram
authors.initials: AB
authors.lastname: Maity
authors.affiliation: Department of Otorhinolaryngology, Institute of Postgraduate Medical Education & Research (IPGME&R), 244B, Acharya J. C. Bose Road, Kolkata, 700020 India.
authors.forename: Ranjan
authors.initials: R
authors.lastname: Paul
keywords: Medullary thyroid carcinoma; Neck mass; Unknown primary