title: Selected factors of fibrinolysis in the Buerger's disease.
abstract: Thrombangiitis obliterans (TAO marked by coexistence of thrombotic and inflammatory changes of neurovascular tract has evoked a considerable dispute concerning pathogenesis of this disease. The aim of the study was to define the level of activation of fibirinolitic system in course of TAO disease by means of determination its basic constituents as well as to examine the essence of level of fibrinolysis disorders in pathogenesis and development of this disease.
  
  
  METHODS
  Fifty patients with thrombangiitis obliterans (TAO), 30 patients with peripheral occlusive disease - PAOD (ASO) and 20 healthy volunteers (K) have been subjected to the examination. We determined the activity some factors of fibrinolysis: t-PA, PAI-1, PAP, plasminogen, α2-antiplasminogen, D-dimmer as well as euglobulin lysis time. The analysis comprised 7 features and 8 factors of variability: a membership to a group of patients, sex, age, smoking, aggravation of the disease within last 3 months, occurrence of Raynaud's symptom, a degree of ischemia according to Fontaine, time the disease lasted.
  
  
  RESULTS
  The significant differences between the average were checked by means of t-Student test or variance analysis (ANOVA) and co-relation rate r (Pearson). We concluded that the average value of PAI-1 in the group TAO was significantly higher than in comparison with ASO group. The increased values were revealed in case of 76 % of patients. The euglobulin lysis time was vitally extended in case of 60% of patients in ASO group. In all three groups higher levels of α2-antiplasmin were detected in case of elderly patients compared to the younger ones.
  
  
  CONCLUSIONS
  The obtained results allow us to ascertain the state of potentially weakened fibrinolysis in case of patients with Buerger's disease as well as with PAOD.
authors.forename: Piotr
authors.initials: P
authors.lastname: Terlecki
authors.forename: Marcin
authors.initials: M
authors.lastname: Feldo
authors.forename: Stanisław
authors.initials: S
authors.lastname: Przywara
authors.forename: Marek
authors.initials: M
authors.lastname: Iłżecki
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Kęsik
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Borowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Wroński
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zubilewicz
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D005342:Fibrinolysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013919:Thromboangiitis Obliterans / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005337:Fibrin