title: Determinants of quality of life in people with epilepsy in Serbia.
abstract: OBJECTIVE
  This study aimed at finding determinants of quality of life in people with epilepsy (PWE) living in Belgrade, Serbia.
  
  
  METHODS
  In this study, we recruited consecutive adults with epilepsy attending our outpatient department. Adult patients (age range: 18-65years) of normal intelligence and without any progressive neurological disease or psychiatric disorder were included in the study. They completed the following questionnaires: QOLIE-31 Inventory (Serbian version), Beck's Depression Inventory-II, Beck's Anxiety Inventory, Symptom Check List-90, and Neurotoxicity Scale-II. Hierarchical multiple regression analysis was performed to assess the predictive effects of some factors on QOLIE-31 Inventory.
  
  
  RESULTS
  The mean QOLIE-31 score of 203 patients who completed the questionnaires was 70.64±17.74. Sociodemographic factors (age, sex, education, and employment) did not significantly predict QOLIE-31 score. Significant determinants of quality of life were clinical characteristics - seizure severity and etiology of epilepsy - accounting for 30.9% of the variance, depressive and anxiety symptoms accounting for 42.8% of the variance, and cognitive effects of antiepileptic drugs, accounting for 1.5% above other variables.
  
  
  CONCLUSIONS
  The results suggest that seizure severity and etiology of epilepsy, depressive and anxiety symptoms, and cognitive adverse medication effects are main determinants of quality of life in this population of PWE.
authors.affiliation: Department for Epilepsy and Clinical Neurophysiology, Institute of Mental Health, Palmotićeva 37, 11000 Belgrade, Serbia. Electronic address: jmtmilov@eunet.rs.
authors.forename: Maja
authors.initials: M
authors.lastname: Milovanović
authors.affiliation: Department for Epilepsy and Clinical Neurophysiology, Institute of Mental Health, Palmotićeva 37, 11000 Belgrade, Serbia; Belgrade University Medical School, Dr Subotića 8, 11000 Belgrade, Serbia.
authors.forename: Žarko
authors.initials: Ž
authors.lastname: Martinović
authors.affiliation: Faculty of Philosophy, Department for Psychology - Statistics, University of Belgrade, Čika Ljubina 18-20, 11000 Belgrade, Serbia.
authors.forename: Oliver
authors.initials: O
authors.lastname: Tošković
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D057189:Checklist; D004827:Epilepsy / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011788:Quality of Life; D012044:Regression Analysis; D055771:Serbia / Q000453:epidemiology; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult
keywords: Anxiety; Depression; Epilepsy; Neurotoxicity; Quality of life