title: LC3-associated phagocytosis.
abstract: A recent report from our group has described that upon engulfment of pathogens, a subset of phagosomes is formed to preserve antigens for prolonged presentation on MHC class II molecules. The distinctive feature of these particular vesicles is their coating with LC3/Atg8, a key component of the autophagy machinery. Here we discuss the possible outcomes of LC3-associated phagocytosis and its implications in the context of immunity.
authors.affiliation: Viral Immunobiology; Institute of Experimental Immunology; University of Zürich; Zürich, Switzerland.
authors.forename: Susana
authors.initials: S
authors.lastname: Romao
authors.affiliation: Viral Immunobiology; Institute of Experimental Immunology; University of Zürich; Zürich, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Münz
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000276:immunology*; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001343:Autophagy / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000276:immunology*; D010588:Phagosomes / Q000276:immunology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000949:Histocompatibility Antigens Class II; D008869:Microtubule-Associated Proteins
keywords: Atg8/LC3; MHC class II; macroautophagy; phagocytosis; phagosomal maturation