title: Commentary on ''dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation''.
abstract: Matsui et al. (2014) delineate a novel pathomechanism for attenuated sweating in atopic dermatitis (AD). They provide evidence that acetylcholine-induced sweating can be inhibited via H1-receptor activation. This work suggests that H1 blockers may be useful in patients with AD.
authors.affiliation: Department of Dermatology and Allergy, Allergy-Centre-Charité, Charité-University Hospital Berlin, Berlin, Germany. Electronic address: torsten.zuberbier@charite.de.
authors.forename: Torsten
authors.initials: T
authors.lastname: Zuberbier
authors.affiliation: Department of Dermatology and Allergy, Allergy-Centre-Charité, Charité-University Hospital Berlin, Berlin, Germany.
authors.forename: Margitta
authors.initials: M
authors.lastname: Worm
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D003876:Dermatitis, Atopic / Q000378:metabolism*; D005260:Female; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D007007:Hypohidrosis / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000235:genetics*; D013546:Sweating / Q000502:physiology*
chemical_list: D011969:Receptors, Histamine H1; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3; D000109:Acetylcholine