title: Associations of serum sclerostin and polymorphisms in the SOST gene with bone mineral density and markers of bone metabolism in postmenopausal Chinese women.
abstract: OBJECTIVE
  The aims of this study were as follows: 1) to evaluate the association of serum sclerostin with bone mineral density (BMD) and markers of bone metabolism in postmenopausal Chinese women and 2) to observe the relationships of single-nucleotide polymorphisms (SNPs) within the sclerostin (SOST) gene with serum sclerostin, BMD, and markers of bone metabolism.
  
  
  METHODS
  A cross-sectional study was conducted with 703 postmenopausal Chinese women. Ten tagging SNPs (rs1234612, rs1513670, rs1634330, rs1708635, rs2023794, rs7220711, rs74252774, rs851057, rs851058, and rs865429) of the SOST gene were genotyped. Serum sclerostin and markers of bone metabolism were measured, including serum intact PTH, 25-hydroxyvitamin D [25(OH)D], procollagen type 1 N-terminal propeptide, and β-CrossLaps of type I collagen containing cross-linked C-telopeptide (β-CTX). The BMD of the lumbar spine and proximal femur were measured by dual-energy X-ray absorptiometry.
  
  
  RESULTS
  Serum sclerostin was positively correlated with BMD at the lumbar spine, femoral neck, and total hip and with serum 25(OH)D (all P < .01) but negatively correlated with β-CTX (P < .01). The significant relationships between serum sclerostin and BMD and with serum β-CTX persisted, even after adjustments for age, body mass index, and serum 25(OH)D (all P < .01). However, there was no correlation between serum sclerostin and age or serum procollagen type 1 N-terminal propeptide. We failed to identify a significant association between the SNP, haplotypes of SOST and BMD, or serum sclerostin.
  
  
  CONCLUSIONS
  Our results suggested that serum sclerostin was positively correlated with the BMD at the lumbar spine, femoral neck, and total hip and with serum 25(OH)D but was negatively correlated with serum β-CTX. Genetic polymorphisms of SOST may not be a major contributor to variations in the serum sclerostin or BMD in postmenopausal Chinese women.
authors.affiliation: Metabolic Bone Diseases and Genetic Research Unit (J.H., H.Zha., C.W., H.Y., W.H., J.G., W.F., Y.H., M.L., Y.L., H.Zhe., Zh.Z.), Department of Osteoporosis and Bone Diseases, and Department of Orthopedics (Ze.Z.), Shanghai Jiao Tong University Affiliated with Sixth People's Hospital 200233 Shanghai, China.
authors.forename: Jinwei
authors.initials: J
authors.lastname: He
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.forename: Zeng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Yue
authors.forename: Weiwei
authors.initials: W
authors.lastname: Hu
authors.forename: Jiemei
authors.initials: J
authors.lastname: Gu
authors.forename: Wenzhen
authors.initials: W
authors.lastname: Fu
authors.forename: Yunqiu
authors.initials: Y
authors.lastname: Hu
authors.forename: Miao
authors.initials: M
authors.lastname: Li
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Zheng
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D015415:Biomarkers / Q000378:metabolism; D015519:Bone Density / Q000235:genetics*; D019485:Bone Morphogenetic Proteins / Q000097:blood* / Q000235:genetics*; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D056726:Genetic Association Studies; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000097:blood / Q000208:ethnology / Q000235:genetics
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; C422903:SOST protein, human