title: Clinical risk factors on survival among HIV-infected children born to HIV-infected mothers.
abstract: OBJECTIVE
  The present study was to investigate clinical risk factors of survival among HIV-infected children born from HIV-infected mothers in the Southern region of Thailand.
  
  
  METHODS
  Data from routine prospective cohort studies between 1990 and 2010 were analyzed In these studies, 1,549 HIV-infected children born to HIV-infected mothers were enrolled at birth and followed longitudinally. Information on demographic, clinical manifestations, and HIV-infection status factors was collected Survival analysis was used to determine risk factors associated with mortality.
  
  
  RESULTS
  Results found that one-fourth of HIV-infected children died (434, 28.02%) during the follow-up period. The follow-up available equals to 135,295 person-months. The incidence rate was 1.03 times per 100 person-months (95% CI: 0.97 to 1.08). The median survival time among HIV-infected children from diagnosis to death was 87.34 months (95% CI: 87.32 to 87.36). HIV-infected children were diagnosed to confirm as AIDS (88. 44%) and symptomatic HIV positive (11.56%). Clinical risk factors on survival among HIV-infected children were found HIV-infected children were more likely to die if they were infected with candidiasis (HR: 1.47, 95% CI: 1.07 to 2.00), Mycobacterium tuberculosis (HR: 1.51, 95% CI: 1.26 to 1.81), and Pneumocystis jiroveci (HR: 1.50, 95% CI: 1.27 to 1.76) as compared to HIV-infected children without clinical manifestation.
  
  
  CONCLUSIONS
  Mortality among infected children born to HIV-positive mothers is high in the Southern region of Thailand Consequently, health service system related to prevent mother-to-child HIV-transmission is needed to improve child survival.
authors.affiliation: Faculty of Health and Sports Science, Thaksin University, Phatthalung Campus, Phatthalung, Thailand. bchaimay@gmail.com
authors.forename: Bhunyabhadh
authors.initials: B
authors.lastname: Chaimay
authors.affiliation: Faculty of Health and Sports Science, Thaksin University, Phatthalung Campus, Phatthalung, Thailand.
authors.forename: Somkiattiyos
authors.initials: S
authors.lastname: Woradet
authors.affiliation: Center for Diseases Control and Prevention Region 12, Songkhla, Thailand.
authors.forename: Sawanya
authors.initials: S
authors.lastname: Chantutanon
authors.affiliation: Center for Diseases Control and Prevention Region 12, Songkhla, Thailand.
authors.forename: Supparaporn
authors.initials: S
authors.lastname: Phuntara
authors.affiliation: Center for Diseases Control and Prevention Region 11, Nakhon Si Thammarat, Thailand.
authors.forename: Kannika
authors.initials: K
authors.lastname: Suwanna
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000401:mortality* / Q000635:transmission; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D012307:Risk Factors; D016019:Survival Analysis