title: Chronic granulomatous disease carrier with recurrent poor obstetric outcome.
abstract: BACKGROUND
  Chronic granulomatous disease is a primary immunodeficiency disorder characterized by severe recurrent bacterial and fungal infections. Female carriers of the X-linked form of the disorder usually are unaffected and rarely have serious infections.
  
  
  METHODS
  A 22-year-old pregnant patient known to be a carrier of the X-linked form of chronic granulomatous disease had a history of chorioamnionitis during her two previous pregnancies. During her third pregnancy, she presented again with the same diagnosis, which resulted in delivery at 25 weeks of gestation.
  
  
  CONCLUSIONS
  Carriers of chronic granulomatous disease should be monitored closely during pregnancy, as if they have the disease. To decrease the risk of infectious morbidity and mortality, obstetricians should have a low threshold for starting prophylactic antibiotics early during pregnancy, even if the patient is asymptomatic.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, Ohio.
authors.forename: Ziad A
authors.initials: ZA
authors.lastname: Haidar
authors.forename: Amol
authors.initials: A
authors.lastname: Malshe
authors.forename: David
authors.initials: D
authors.lastname: McKenna
mesh_terms: D002821:Chorioamnionitis / Q000209:etiology*; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000151:congenital; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000209:etiology*; D011256:Pregnancy Outcome; D012008:Recurrence; D055815:Young Adult