title: MRI-based finite element simulation on radiofrequency ablation of thyroid cancer.
abstract: In order to provide a quantitative disclosure on the RFA (radiofrequency ablation)-induced thermal ablation effects within thyroid tissues, this paper has developed a three-dimensional finite element simulation strategy based on a MRI (magnetic resonance imaging)-reconstructed model. The thermal lesion's growth was predicted and interpreted under two treatment conditions, i.e. single-cooled-electrode modality and two-cooled-electrode system. The results show that the thermal lesion's growth is significantly affected by two factors including the position of RF electrode and thermal-physiological behavior of the breathing airflow. Additional parametric studies revealed several valuable phenomena, e.g. with the electrode's movement, thermal injury with varying severity would happen to the trachea wall. Besides, the changes in airflow mass produced evident effects on the total heat flux of thyroid surface, while the changes in breathing frequency only generated minor effects that can be ignored. The present study provided a better understanding on the thermal lesions of RFA within thyroid domain, which will help guide future treatment of the thyroid cancer.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Jin
authors.affiliation: Beijing Key Laboratory of Cryo-Biomedical Engineering, and Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Zhizhu
authors.initials: Z
authors.lastname: He
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, PR China; Beijing Key Laboratory of Cryo-Biomedical Engineering, and Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China. Electronic address: jliubme@tsinghua.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
mesh_terms: D017115:Catheter Ablation; D004566:Electrodes; D020342:Finite Element Analysis; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008954:Models, Biological; D013964:Thyroid Neoplasms / Q000601:surgery*
keywords: Radiofrequency ablation; Real geometrical model; Thermal lesion estimation; Thyroid cancer; Trachea lesion