title: Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity.
abstract: Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions is a novel antiausterity strategy in anticancer drug discovery. In this study, the methanolic extract of the leaves of Artocarpus altilis showed 100 % preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions at a concentration of 50 µg/mL. Further investigation of this extract led to the isolation of eight new geranylated dihydrochalcones named sakenins A-H (1-8) together with four known compounds (9-12). Among them, sakenins F (6) and H (8) were identified as potent preferentially cytotoxic candidates with PC50 values of 8.0 µM and 11.1 µM, respectively.
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
authors.forename: Mai Thanh Thi
authors.initials: MT
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
authors.forename: Nhan Trung
authors.initials: NT
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
authors.forename: Khang Duy Huu
authors.initials: KD
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
authors.forename: Hien Thu Thi
authors.initials: HT
authors.lastname: Dau
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
authors.forename: Hai Xuan
authors.initials: HX
authors.lastname: Nguyen
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
authors.forename: Phu Hoang
authors.initials: PH
authors.lastname: Dang
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
authors.forename: Tam Minh
authors.initials: TM
authors.lastname: Le
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City, Vietnam.
authors.forename: Trong Huu
authors.initials: TH
authors.lastname: Nguyen Phan
authors.affiliation: Vietnam Military Medical University, Ha Noi, Vietnam.
authors.forename: Anh Hai
authors.initials: AH
authors.lastname: Tran
authors.affiliation: Vietnam Military Medical University, Ha Noi, Vietnam.
authors.forename: Bac Duy
authors.initials: BD
authors.lastname: Nguyen
authors.affiliation: Frontier Research Core for Life Sciences, University of Toyama, Toyama, Japan.
authors.forename: Jun-Ya
authors.initials: JY
authors.lastname: Ueda
authors.affiliation: Frontier Research Core for Life Sciences, University of Toyama, Toyama, Japan.
authors.forename: Suresh
authors.initials: S
authors.lastname: Awale
mesh_terms: D031622:Artocarpus / Q000737:chemistry*; D045744:Cell Line, Tumor; D047188:Chalcones / Q000494:pharmacology*; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D010190:Pancreatic Neoplasms / Q000473:pathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D059016:Tumor Microenvironment
chemical_list: D047188:Chalcones; D003603:Cytotoxins; D010936:Plant Extracts; C015812:dihydrochalcone