title: [Advance in producing higher alcohols by microbial cell factories].
abstract: Higher alcohols have a high energy density, low hygroscopicity and can be mixed with gasoline at any ratio. It is the trend to replace fossil fuels with biofuels produced via microbial fermentation of renewable resources. We reviewed the progress in the development of engineered Saccharomyces cerevisiae and Escherichia coli that can produce higher alcohols, as well as the related technology platforms. We mainly focused on the construction of CoA-dependent pathways and alpha-keto acid mediated non-fermentative pathways, analyzed their respective characteristics, and summarized the construction strategies. The problems to be solved and future research direction were also discussed.
authors.affiliation: College of Bioscience and Bioengineering, Hebei University of Economics and Business, Shijiazhuang 050061, Hebei, China. liuzengran@163.com
authors.forename: Zengran
authors.initials: Z
authors.lastname: Liu
authors.affiliation: College of Bioscience and Bioengineering, Hebei University of Economics and Business, Shijiazhuang 050061, Hebei, China.
authors.forename: Guangyi
authors.initials: G
authors.lastname: Zhang
mesh_terms: D000438:Alcohols / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D007218:Industrial Microbiology / Q000379:methods; D060847:Metabolic Engineering / Q000379:methods*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*
chemical_list: D000438:Alcohols