title: The effects of different hyperbaric oxygen manipulations in rats after traumatic brain injury.
abstract: The protective effects of hyperbaric oxygenation following traumatic brain injury have been widely investigated; however, few studies have made systematic comparisons between the different hyperbaric oxygenation manipulations and their corresponding effects. In this study, male Sprague-Dawley rats were observed at 4h, 15d and 75d after traumatic brain injury. The effects of the different hyperbaric oxygenation manipulations on the rats were compared based on morphological, molecular biological and behavioral tests. Our results showed that hyperbaric oxygenation inhibited cell apoptosis in the rat hippocampus and improved their physiological functions. The effects observed in the hyperbaric oxygen-early group were better than the hyperbaric oxygen-delayed group, and the hyperbaric oxygen-early-delayed group demonstrated the best effects among all the groups. Our results showed the hyperbaric oxygenation was recommended early and delayed post-traumatic brain injury and exposure to hyperbaric oxygenation should be prolonged. These findings provide new ideal therapeutic insight for the clinical treatment of traumatic brain injury.
authors.affiliation: Department of Neurosurgery, The Zhumadian city center Hospital, 747 Zhonghua Road, Zhumadian 463000, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of ICU, The Zhumadian city center Hospital, 747 Zhonghua Road, Zhumadian 463000, China.
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Zhang
authors.affiliation: Department of Burn, The 159th Hospital of PLA, 1 Fengguang Road, Zhumadian 463008, China.
authors.forename: Guo-An
authors.initials: GA
authors.lastname: Lin
authors.affiliation: Department of Pain, The Zhumadian city center Hospital, 747 Zhonghua Road, Zhumadian 463000, China.
authors.forename: He-Qiu
authors.initials: HQ
authors.lastname: Xie
authors.affiliation: School of Statistics, Xi'an University of Finance and Economics, Xi'an 710061, China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Pan
authors.affiliation: Department of Oncology, The 159th Hospital of PLA, 1 Fengguang Road, Zhumadian 463008, China.
authors.forename: Ben-Qing
authors.initials: BQ
authors.lastname: Huang
authors.affiliation: Department of Neurosurgery, The Zhumadian city center Hospital, 747 Zhonghua Road, Zhumadian 463000, China.
authors.forename: Ji-Dong
authors.initials: JD
authors.lastname: Liu
authors.affiliation: Department of Neurosurgery, The Zhumadian city center Hospital, 747 Zhonghua Road, Zhumadian 463000, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of student affairs, Xinxiang Medical University, Xinxiang 453003, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Department of Neurosurgery, The Zhumadian city center Hospital, 747 Zhonghua Road, Zhumadian 463000, China. Electronic address: zmdlil@163.com.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Neurosurgery, The Zhumadian city center Hospital, 747 Zhonghua Road, Zhumadian 463000, China. Electronic address: yangyang19800627@163.com.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Chen
mesh_terms: D000818:Animals; D017209:Apoptosis; D001812:Blood-Brain Barrier / Q000378:metabolism; D001929:Brain Edema / Q000473:pathology / Q000628:therapy; D001930:Brain Injuries / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006931:Hyperbaric Oxygenation; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D008297:Male; D017207:Rats, Sprague-Dawley
chemical_list: C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit
keywords: Hyperbaric oxygenation; Traumatic brain injury; Treatment