title: Contributions of COMT Val¹⁵⁸ Met to cognitive stability and flexibility in infancy.
abstract: Adaptive behavior requires focusing on relevant tasks while remaining sensitive to novel information. In adult studies of cognitive control, cognitive stability involves maintaining robust cognitive representations while cognitive flexibility involves updating of representations in response to novel information. Previous adult research has shown that the Met allele of the COMT Val(158) Met gene is associated with enhanced cognitive stability whereas the Val allele is associated with enhanced cognitive flexibility. Here we propose that the stability/flexibility framework can also be applied to infant research, with stability mapping onto early indices of behavioral regulation and flexibility mapping onto indices of behavioral reactivity. From this perspective, the present study examined whether COMT genotype was related to 7-month-old infants' reactivity to novel stimuli and behavioral regulation. Cognitive stability and flexibility were assessed using (1) a motor approach task, (2) a habituation task, and (3) a parental-report measure of temperament. Val carriers were faster to reach for novel toys during the motor approach task and received higher scores on the temperament measure of approach to novelty. Met carriers showed enhanced dishabituation to the novel stimulus during the habituation task and received higher scores on the temperament measures of sustained attention and behavioral regulation. Overall, these results are consistent with adult research suggesting that the Met and Val alleles are associated with increased cognitive stability and flexibility, respectively, and thus suggest that COMT genotype may similarly affect cognitive function in infancy.
authors.affiliation: Department of Cognitive, Linguistic, and Psychological Sciences, Brown University, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Markant
authors.forename: Dante
authors.initials: D
authors.lastname: Cicchetti
authors.forename: Susan
authors.initials: S
authors.lastname: Hetzel
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Thomas
mesh_terms: D002394:Catechol O-Methyltransferase / Q000235:genetics*; D003071:Cognition / Q000502:physiology*; D005260:Female; D005838:Genotype; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006801:Humans; D007223:Infant; D018730:Infant Behavior / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D008297:Male; D008960:Models, Psychological; D020125:Mutation, Missense / Q000235:genetics*; D011597:Psychomotor Performance / Q000502:physiology
chemical_list: C588010:COMT protein, human; D002394:Catechol O-Methyltransferase