title: [Multivariate analysis of the efficacy of laparoscopic splenectomy in the treatment of immune thrombocytopenic purpura].
abstract: OBJECTIVE
  To identify factors that can effectively predict the efficacy of laparoscopic splenectomy (LS) in the treatment of immune thrombocytopenic purpura (ITP).
  
  
  METHODS
  From January 2007 to September 2012, 78 patients with ITP underwent laparoscopic splenectomy were retrospectively analyzed. According to the postoperative platelet (PLT) count and haemorrhagic manifestations, they were divided into effective group and ineffective group. Nine influencing factors were univariate analyzed and multivariate analyzed.
  
  
  RESULTS
  In effective group (65 cases) and ineffective group (13 cases), average PLT count of 1 day before surgery was 47×10(9)/L vs. 21×10(9)/L, average operative time was (166 ± 46) minutes vs. (139 ± 29) minutes. Univariate analysis result: PLT count of 1 day before surgery (Z = -2.776, P = 0.005) and operative time (t = 2.723, P = 0.011) was statistically significant in 2 groups, the rest factors did not significantly influence the result. Multivariate analysis revealed that only PLT count of 1 day before surgery was statistically significant (OR = 0.964, 95%CI: 0.932-0.997, P = 0.031) in 2 groups, but operative time (P = 0.051) was not statistically significant.
  
  
  CONCLUSIONS
  PLT count of 1 day before surgery is a predict factor in LS for ITP. Because of the limited sample number, further multi-center prospective study with large sample is warrant.
authors.affiliation: Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Jun-wei
authors.initials: JW
authors.lastname: Huang
authors.affiliation: Email: yxiong1964@yahoo.com.cn.
authors.forename: Xiong
authors.initials: X
authors.lastname: Yan
authors.forename: Jun
authors.initials: J
authors.lastname: Zheng
authors.forename: Xian-bing
authors.initials: XB
authors.lastname: Kong
authors.forename: Shi-qiao
authors.initials: SQ
authors.lastname: Luo
authors.forename: Hong-bin
authors.initials: HB
authors.lastname: Zhang
authors.forename: Xiao-qiong
authors.initials: XQ
authors.lastname: Tang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000601:surgery*; D012189:Retrospective Studies; D013156:Splenectomy; D016896:Treatment Outcome; D055815:Young Adult