title: Discovering the Hippo pathway protein-protein interactome.
abstract: The Hippo pathway is a signal transduction pathway that regulates organ growth, stem cell biology, regeneration and cancer. Three recent proteomic studies with Hippo pathway components uncovered extensive networks of interacting proteins revealing novel connections to cell-cell junctions, regulation by vesicle trafficking, and phosphorylation-dependent remodeling of the interactome, and provide a rich landscape of novel interactors ripe for mechanistic studies.
authors.affiliation: 1] VIB Center for the Biology of Disease, University of Leuven, 3000 Leuven, Belgium [2] KU Leuven Center for Human Genetics, University of Leuven, 3000 Leuven, Belgium.
authors.forename: Iván M
authors.initials: IM
authors.lastname: Moya
authors.affiliation: 1] VIB Center for the Biology of Disease, University of Leuven, 3000 Leuven, Belgium [2] KU Leuven Center for Human Genetics, University of Leuven, 3000 Leuven, Belgium.
authors.forename: Georg
authors.initials: G
authors.lastname: Halder
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism; D004330:Drosophila; D000090683:Hippo Signaling Pathway; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D010766:Phosphorylation; D060066:Protein Interaction Maps; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D021381:Protein Transport; D034622:RNA Interference; D015398:Signal Transduction; D062725:Tight Junction Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins; D062725:Tight Junction Proteins; D014157:Transcription Factors; D017346:Protein Serine-Threonine Kinases