title: Quetiapine responsive catatonia in an autistic patient with comorbid bipolar disorder and idiopathic basal ganglia calcification.
abstract: BACKGROUND
  Bipolar disorder (BD) has been linked with the manifestation of catatonia in subjects with autism spectrum disorders (ASD). Idiopathic basal ganglia calcification (IBGC) is characterized by movement disorders and various neuropsychiatric disturbances including mood disorder.
  
  
  METHODS
  We present a patient with ASD and IBGC who developed catatonia presenting with prominent dystonic feature caused by comorbid BD, which was treated effectively with quetiapine.
  
  
  CONCLUSIONS
  In addition to considering the possibility of neurodegenerative disease, careful psychiatric interventions are important to avoid overlooking treatable catatonia associated with BD in cases of ASD presenting with both prominent dystonic features and apparent fluctuation of the mood state.
authors.affiliation: Department of Child and Adolescent Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Japan; Department of Neuropsychiatry, University of Fukui, Japan. Electronic address: mak1977019@yahoo.co.jp.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ishitobi
authors.affiliation: Department of Pediatrics, University of Fukui, Japan. Electronic address: kawatani@u-fukui.ac.jp.
authors.forename: Masao
authors.initials: M
authors.lastname: Kawatani
authors.affiliation: Department of Neuropsychiatry, University of Fukui, Japan. Electronic address: morio@u-fukui.ac.jp.
authors.forename: Mizuki
authors.initials: M
authors.lastname: Asano
authors.affiliation: Research Center for Child Mental Development, University of Fukui, Japan. Electronic address: hirotaka@u-fukui.ac.jp.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kosaka
authors.affiliation: Department of Neuropsychiatry, University of Fukui, Japan. Electronic address: gotot@u-fukui.ac.jp.
authors.forename: Takashi
authors.initials: T
authors.lastname: Goto
authors.affiliation: Hiratani Child Development Clinic, Fukui, Japan. Electronic address: m-hiratani@hiratani-c.jp.
authors.forename: Michio
authors.initials: M
authors.lastname: Hiratani
authors.affiliation: Department of Neuropsychiatry, University of Fukui, Japan. Electronic address: waday@u-fukui.ac.jp.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Wada
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D001479:Basal Ganglia / Q000473:pathology; D001714:Bipolar Disorder / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002114:Calcinosis / Q000139:chemically induced / Q000150:complications* / Q000473:pathology; D002389:Catatonia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D003937:Diagnosis, Differential; D003987:Dibenzothiazepines / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D000069348:Quetiapine Fumarate; D014057:Tomography, X-Ray Computed
chemical_list: D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate
keywords: Autism; Basal ganglia calcification; Bipolar disorder; Catatonia; Dystonia; Quetiapine