title: The risk of cancer among patients with sleep disturbance: a nationwide retrospective study in Taiwan.
abstract: OBJECTIVE
  To investigate the risk of cancer among patients with nonapnea sleep disorders (SDs).
  
  
  METHODS
  We included newly diagnosed SD patients aged 20 years and older without antecedent cancer between 2000 and 2010 from the National Health Insurance Research Database. Standardized incidence ratios (SIRs) of cancers were calculated to compare the cancer incidence of patients with SD with that of the general population.
  
  
  RESULTS
  During the 10-year study period, 2062 cancers developed among 63,381 SD patients, who were observed for 382,826 person-years (median follow-up of 6.23 years). The SIR for all cancers was 1.19 (95% confidence interval [CI], 1.14e1.24). For specific cancer types, SD patients exhibited an increased SIR for liver and lung cancers (1.44; 95% CI, 1.28e1.61 and 1.34; 95% CI, 1.18e1.51, respectively).
  
  
  CONCLUSIONS
  We observed that overall cancer risk is increased among Asian SD patients. In terms of individual cancers, the risks of liver and lung cancers were elevated. Clinicians should be aware of the possibility of increased liver and lung cancers among SD patients in Taiwan. A prospective study is necessary to confirm these findings.
authors.forename: Li-Yu
authors.initials: LY
authors.lastname: Hu
authors.forename: Pan-Ming
authors.initials: PM
authors.lastname: Chen
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Hu
authors.forename: Cheng-Che
authors.initials: CC
authors.lastname: Shen
authors.forename: Chin-Lin
authors.initials: CL
authors.lastname: Perng
authors.forename: Tung-Ping
authors.initials: TP
authors.lastname: Su
authors.forename: Sang-Hue
authors.initials: SH
authors.lastname: Yen
authors.forename: Cheng-Hwai
authors.initials: CH
authors.lastname: Tzeng
authors.forename: Tzeon-Jye
authors.initials: TJ
authors.lastname: Chiou
authors.forename: Chiu-Mei
authors.initials: CM
authors.lastname: Yeh
authors.forename: Tzeng-Ji
authors.initials: TJ
authors.lastname: Chen
authors.forename: Wei-Shu
authors.initials: WS
authors.lastname: Wang
authors.forename: Chia-Jen
authors.initials: CJ
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D038801:International Classification of Diseases; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D011159:Population Surveillance; D012189:Retrospective Studies; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000150:complications*; D012959:Socioeconomic Factors; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult