title: A new and efficient method for the synthesis of novel 3-acetyl coumarins oxadiazoles derivatives with expected biological activity.
abstract: This paper presents the design of some novel 3-acetylcoumarin derivatives, based on minimal inhibitory concentration values (MICs) previously obtained against some microorganism cultures, Gram positive and negative bacteria and fungi. Some of these molecules exhibited antibacterial activity against S. aureus, comparable to that of the standard used (impinem). The in vitro antioxidant activities of the novel 3-acetylcoumarin oxadiazoles were assayed by the quantitative 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity method. The compounds 5c,d proved to be the most active, showing the highest capacity to deplete the DPPH radicals. Structure elucidation of the products has been accomplished on the basis of IR, 1H-NMR, 13C-NMR, NOESY and HMBC NMR data.
authors.affiliation: Chemistry Department, College of Science and Arts, Al-Rass, P.O. Box 53, Qassim University, Buraidah 51477, Saudi Arabia.
authors.forename: Abdullah Sulaiman
authors.initials: AS
authors.lastname: Al-Ayed
authors.affiliation: Chemistry Department, College of Science and Arts, Al-Rass, P.O. Box 53, Qassim University, Buraidah 51477, Saudi Arabia. naceur.hamdi@isste.rnu.tn.
authors.forename: Naceur
authors.initials: N
authors.lastname: Hamdi
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D015725:Fluconazole / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D019906:Nuclear Magnetic Resonance, Biomolecular; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D012485:Salmonella typhi / Q000187:drug effects; D012763:Shigella flexneri / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D003374:Coumarins; D016166:Free Radical Scavengers; D005609:Free Radicals; D010069:Oxadiazoles; D010851:Picrates; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C094809:3-acetylcoumarin; D015725:Fluconazole; C004931:1,1-diphenyl-2-picrylhydrazyl