title: Effects of age and sex on the hematology and blood chemistry of Tibetan macaques (Macaca thibetana).
abstract: Tibetan macaques (Macaca thibetana), also known as Chinese stump-tailed macaques, are a threatened primate species. Although Tibetan macaques are Old World monkeys in the genus of Macaca, limited age- and sex-related physiologic data are available for this particular species. We used 69 apparently healthy Tibetan male and female macaques to explore the effect of age and sex on physiologic parameters. Somatometric measurements, biochemistry, and hematologic parameters were analyzed. Significant age-related differences were found for weight, BMI, RBC count, Hgb, Hct, neutrophils, eosinophil count, ALT, AST, ALP, GGT, creatine kinase (muscle and brain subtypes), LDH, α-amylase, creatinine, apolipoprotein A1, total protein, albumin, cholesterol, HDL, and potassium. Significant differences by sex were noted for weight, BMI, ALT, total bilirubin, and indirect bilirubin. An interaction between age and sex accounted for statistically significant differences in the values for weight, BMI, and lymphocyte and eosinophil counts. These physiologic data will provide veterinarians and researchers with important age- and sex-specific reference ranges for evaluating experimental results from Tibetan macaques.
authors.affiliation: Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.affiliation: Institute of Laboratory Animals of Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Yi
authors.affiliation: Beijing Geriatric Healthcare Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Sun
authors.affiliation: Institute of Laboratory Animals of Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Institute of Laboratory Animals of Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Yang
authors.affiliation: Institute of Laboratory Animals of Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan Province, China.
authors.forename: Hongxing
authors.initials: H
authors.lastname: Wang
authors.affiliation: Wincon Laboratory, Wincon TheraCells Biotechnologies, Nanning, Guangxi Province, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China.
authors.forename: Yu Alex
authors.initials: YA
authors.lastname: Zhang
authors.affiliation: Department of Neuro-biology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China. fyuee@hotmail.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Yue
mesh_terms: D000375:Aging / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D000818:Animals; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D004573:Electrolytes / Q000097:blood*; D005260:Female; D006401:Hematologic Agents / Q000097:blood*; D006728:Hormones / Q000097:blood; D006801:Humans; D008251:Macaca / Q000097:blood* / Q000378:metabolism / Q000502:physiology; D008297:Male; D012016:Reference Values; D012737:Sex Factors
chemical_list: D004573:Electrolytes; D006401:Hematologic Agents; D006728:Hormones