title: Diagnosis and classification of autoimmune gastritis.
abstract: Autoimmune gastritis is a silent and highly prevalent disease that only becomes clinically manifested with progression to corpus atrophy and development of iron deficient or B12-deficient (pernicious) anaemia. Autoimmune gastritis is associated with autoimmune thyroiditis and type 1 diabetes mellitus. Corpus atrophy may be complicated by gastric carcinoids and gastric cancer. Laboratory diagnosis of autoimmune gastritis rests on serum biomarkers of antibody to parietal cell H/K ATPase and intrinsic factor and corpus atrophy on serum biomarkers of gastrin and pepsinogen levels. Subjects with asymptomatic parietal cell antibody should be regularly assessed for serum biomarkers for progression to corpus atrophy, development of iron and B12 deficiency anaemia and for associated autoimmune thyroiditis and type 1 diabetes mellitus.
authors.affiliation: Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria, Australia; Healthscope Pathology, 1868 Dandenong Rd Clayton, Victoria 3168, Australia. Electronic address: ban-hock.toh@monash.edu.
authors.forename: Ban-Hock
authors.initials: BH
authors.lastname: Toh
mesh_terms: D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D005756:Gastritis / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D016481:Helicobacter Infections; D016480:Helicobacter pylori / Q000502:physiology; D006801:Humans; D015995:Prevalence
chemical_list: D015415:Biomarkers