title: EUCAST technical note on Candida and micafungin, anidulafungin and fluconazole.
abstract: The European Committee on Antimicrobial Susceptibility Testing Subcommittee on Antifungal Susceptibility Testing has determined breakpoints for micafungin and revised breakpoints for anidulafungin and fluconazole for Candida spp. This Technical Note is based on the corresponding rationale documents (http://www.eucast.org). The micafungin breakpoints are based on PK data, animal PK/PD data, microbiological data and clinical experience. The anidulafungin breakpoints for C. parapsilosis and fluconazole breakpoints for C. glabrata have been modified to species-specific values that categorise the wild-type as intermediate to accommodate use of these compounds in some clinical situations.
authors.affiliation: Unit of Mycology, Department of Microbiology & Infection Control, Statens Serum Institute, Copenhagen, Denmark.
authors.forename: Maiken Cavling
authors.initials: MC
authors.lastname: Arendrup
authors.forename: Manuel
authors.initials: M
authors.lastname: Cuenca-Estrella
authors.forename: Cornelia
authors.initials: C
authors.lastname: Lass-Flörl
authors.forename: William W
authors.initials: WW
authors.lastname: Hope
mesh_terms: D000077612:Anidulafungin; D000818:Animals; D000935:Antifungal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D054714:Echinocandins / Q000493:pharmacokinetics / Q000494:pharmacology*; D005060:Europe; D015725:Fluconazole / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D055666:Lipopeptides / Q000493:pharmacokinetics / Q000494:pharmacology*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests / Q000592:standards
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D015725:Fluconazole; D000077612:Anidulafungin; D000077551:Micafungin
keywords: Candida; EUCAST breakpoints; MIC; microdilution; susceptibility testing