title: New vaccines against influenza virus.
abstract: Vaccination is one of the most effective and cost-benefit interventions that prevent the mortality and reduce morbidity from infectious pathogens. However, the licensed influenza vaccine induces strain-specific immunity and must be updated annually based on predicted strains that will circulate in the upcoming season. Influenza virus still causes significant health problems worldwide due to the low vaccine efficacy from unexpected outbreaks of next epidemic strains or the emergence of pandemic viruses. Current influenza vaccines are based on immunity to the hemagglutinin antigen that is highly variable among different influenza viruses circulating in humans and animals. Several scientific advances have been endeavored to develop universal vaccines that will induce broad protection. Universal vaccines have been focused on regions of viral proteins that are highly conserved across different virus subtypes. The strategies of universal vaccines include the matrix 2 protein, the hemagglutinin HA2 stalk domain, and T cell-based multivalent antigens. Supplemented and/or adjuvanted vaccination in combination with universal target antigenic vaccines would have much promise. This review summarizes encouraging scientific advances in the field with a focus on novel vaccine designs.
authors.affiliation: Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA, USA.
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Lee
authors.affiliation: Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA, USA.
authors.forename: Ki-Hye
authors.initials: KH
authors.lastname: Kim
authors.affiliation: Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA, USA.
authors.forename: Eun-Ju
authors.initials: EJ
authors.lastname: Ko
authors.affiliation: Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA, USA.
authors.forename: Yu-Na
authors.initials: YN
authors.lastname: Lee
authors.affiliation: Animal and Plant Quarantine Agency, Anyang, Korea.
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Kim
authors.affiliation: Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA, USA.
authors.forename: Young-Man
authors.initials: YM
authors.lastname: Kwon
authors.affiliation: Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA, USA.
authors.forename: Yinghua
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA, USA.
authors.forename: Min-Kyoung
authors.initials: MK
authors.lastname: Cho
authors.affiliation: Animal and Plant Quarantine Agency, Anyang, Korea.
authors.forename: Youn-Jeong
authors.initials: YJ
authors.lastname: Lee
authors.affiliation: Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA, USA.
authors.forename: Sang-Moo
authors.initials: SM
authors.lastname: Kang
keywords: M2 protein; Stalk domain; Supplemented vaccination; T cell immunity; Universal vaccines