title: L-arginine for the treatment of centrally obese subjects: a pilot study.
abstract: BACKGROUND
  Visceral adiposity has been linked to higher rates of cardiometabolic risk than other types of adiposity. Waist circumference (WC) is the best anthropomorphic surrogate of visceral adiposity. Reductions in central adiposity may decrease cardiovascular risk. Animal studies have demonstrated that L-arginine reduces visceral adiposity and fat mass. The primary aim of our study was to assess the efficacy of L-arginine for reducing central adiposity in nondiabetic obese subjects. Secondary aims were to assess the efficacy of L-arginine for decreasing body mass index (BMI), waist-to-hip ratio (WHR), and weight.
  
  
  METHODS
  Female subjects (n = 20) were included if they: were ≥ 18 years and ≤ 40 years of age, had a BMI of ≥ 30 and ≤ 40 kg/m(2), had a WC ≥ 89 cm. Subjects received 3 g of L-arginine three times a day for 12 weeks and were counseled on lifestyle modification.
  
  
  RESULTS
  Overall, L-arginine was well tolerated with no clinically significant adverse events. Serum L-arginine levels were significantly increased from baseline at both 6 and 12 weeks (p < .05). WC (mean ± SD) decreased from 115.6 ± 12.7 cm at baseline to 109.2 ± 11.7 cm at 12 weeks (p = .0004). Weight (mean ± SD) decreased from 98.6 ± 19.7 kg at baseline to 95.7 ± 18.6 kg at 12 weeks (p = .015). Significant reductions from baseline were also observed in BMI and WHR.
  
  
  CONCLUSIONS
  L-Arginine may be effective at reducing central adiposity in obese patients.
authors.affiliation: 1Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Hurt
authors.forename: Jon O
authors.initials: JO
authors.lastname: Ebbert
authors.forename: Darrell R
authors.initials: DR
authors.lastname: Schroeder
authors.forename: Ivana T
authors.initials: IT
authors.lastname: Croghan
authors.forename: Brent A
authors.initials: BA
authors.lastname: Bauer
authors.forename: Stephen A
authors.initials: SA
authors.lastname: McClave
authors.forename: John M
authors.initials: JM
authors.lastname: Miles
authors.forename: Craig J
authors.initials: CJ
authors.lastname: McClain
mesh_terms: D050154:Adiposity / Q000187:drug effects; D000328:Adult; D001120:Arginine / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D056128:Obesity, Abdominal / Q000188:drug therapy* / Q000378:metabolism; D010865:Pilot Projects; D055105:Waist Circumference / Q000187:drug effects*; D049629:Waist-Hip Ratio
chemical_list: D001120:Arginine