title: IL-17: a key player in the P. acnes inflammatory cascade?
abstract: Recent advances in our understanding of inflammatory skin diseases now afford an opportunity to delve deeper into microbial/host interactions in acne. Agak et al. report that Propionibacterium acnes induces IL-17 expression in peripheral blood mononuclear cells and present new evidence that IL-17+ cells are found in the perifollicular infiltrate of comedones. Additional studies are needed to assess the clinical relevance of IL-17 in acne.
authors.affiliation: Department of Dermatology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA. Electronic address: dthiboutot@psu.edu.
authors.forename: Diane M
authors.initials: DM
authors.lastname: Thiboutot
authors.affiliation: Department of Dermatology, Harrogate and District NHS Foundation Trust, Harrogate, UK.
authors.forename: Alison M
authors.initials: AM
authors.lastname: Layton
authors.affiliation: Department of Dermatology, Harrogate and District NHS Foundation Trust, Harrogate, UK.
authors.forename: E
authors.initials: E
authors.lastname: Anne Eady
mesh_terms: D000152:Acne Vulgaris / Q000276:immunology*; D016908:Gram-Positive Bacterial Infections / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D011425:Propionibacterium acnes / Q000276:immunology*; D014801:Vitamin A / Q000378:metabolism*; D014807:Vitamin D / Q000276:immunology*
chemical_list: C508717:IL17A protein, human; D020381:Interleukin-17; D014801:Vitamin A; D014807:Vitamin D