title: The current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine.
abstract: The recent availability of human cardiomyocytes derived from induced pluripotent stem (iPS) cells opens new opportunities to build in vitro models of cardiac disease, screening for new drugs, and patient-specific cardiac therapy. Notably, the use of iPS cells enables studies in the wide pool of genotypes and phenotypes. We describe progress in reprogramming of induced pluripotent stem (iPS) cells towards the cardiac lineage/differentiation. The focus is on challenges of cardiac disease modeling using iPS cells and their potential to produce safe, effective and affordable therapies/applications with the emphasis of cardiac tissue engineering. We also discuss implications of human iPS cells to biological research and some of the future needs.
authors.affiliation: 3B's Research Group - Biomaterials, Biodegradables and Biomimetics, University of Minho, Guimarães, Portugal.
authors.forename: Ana M
authors.initials: AM
authors.lastname: Martins
authors.forename: Gordana
authors.initials: G
authors.lastname: Vunjak-Novakovic
authors.forename: Rui L
authors.initials: RL
authors.lastname: Reis
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002478:Cells, Cultured; D006008:Glycogen Storage Disease / Q000628:therapy; D006331:Heart Diseases / Q000628:therapy*; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology* / Q000637:transplantation; D008954:Models, Biological; D032383:Myocytes, Cardiac / Q000378:metabolism; D044968:Regenerative Medicine; D023822:Tissue Engineering