title: Comparison of monochromatic aberrations in young adults with different visual acuity and refractive errors.
abstract: OBJECTIVE
  To compare the monochromatic aberrations in a large cohort of 20-year-old Australians with differing levels of visual acuity and explore the relationship between these aberrations and refractive error.
  
  
  METHODS
  Lions Eye Institute, Perth, Western Australia, Australia.
  
  
  METHODS
  Cross-sectional analysis of a population-based cohort.
  
  
  METHODS
  Monochromatic aberrations were measured using a Zywave II wavefront aberrometer with natural pupils in a dark room. The logMAR corrected distance visual acuity (CDVA) was measured monocularly under normal illumination. Cycloplegic autorefraction was also performed.
  
  
  RESULTS
  The study enrolled 2039 eyes of 1040 participants. Data from 1007 right eyes were analyzed. The median CDVA and spherical equivalent were -0.06 logMAR (interquartile range [IQR], -0.10 to 0.00) and +0.25 diopters (D) (IQR, -0.38 to 0.63), respectively. The median 6.0 mm higher-order aberration (HOA) was 0.58 μm (IQR, 0.44 to 0.79). Coma-like aberrations and 3rd-, 4th-, and 5th-order HOAs were significantly different between subjects with a CDVA of -0.10 logMAR or better and those with a CDVA worse than -0.10 logMAR. Fourth-order aberrations Z(4,-4) (P=.024) and Z(4,-2) (P=.029) and 2nd-order aberration Z(2,0) (P<.001) differed significantly between myopic eyes, emmetropic eyes, and hyperopic eyes. Subjects with higher myopia had slightly higher total HOAs.
  
  
  CONCLUSIONS
  The HOAs in this population were marginally higher than previously reported values. The findings confirm there is a difference in monochromatic aberrations between different vision and refractive groups. Results in this study will benefit decision-making processes in the clinical setting.
authors.affiliation: From the University of Western Australia Centre for Ophthalmology and Visual Science and Lions Eye Institute(Yazar, Hewitt, Forward, McKnight, Tan, Mackey) and the Telethon Institute for Child Health Research (Mountain), Perth, Western Australia, Australia. Electronic address: seyhanyazar@lei.org.au.
authors.forename: Seyhan
authors.initials: S
authors.lastname: Yazar
authors.affiliation: From the University of Western Australia Centre for Ophthalmology and Visual Science and Lions Eye Institute(Yazar, Hewitt, Forward, McKnight, Tan, Mackey) and the Telethon Institute for Child Health Research (Mountain), Perth, Western Australia, Australia.
authors.forename: Alex W
authors.initials: AW
authors.lastname: Hewitt
authors.affiliation: From the University of Western Australia Centre for Ophthalmology and Visual Science and Lions Eye Institute(Yazar, Hewitt, Forward, McKnight, Tan, Mackey) and the Telethon Institute for Child Health Research (Mountain), Perth, Western Australia, Australia.
authors.forename: Hannah
authors.initials: H
authors.lastname: Forward
authors.affiliation: From the University of Western Australia Centre for Ophthalmology and Visual Science and Lions Eye Institute(Yazar, Hewitt, Forward, McKnight, Tan, Mackey) and the Telethon Institute for Child Health Research (Mountain), Perth, Western Australia, Australia.
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: McKnight
authors.affiliation: From the University of Western Australia Centre for Ophthalmology and Visual Science and Lions Eye Institute(Yazar, Hewitt, Forward, McKnight, Tan, Mackey) and the Telethon Institute for Child Health Research (Mountain), Perth, Western Australia, Australia.
authors.forename: Alex
authors.initials: A
authors.lastname: Tan
authors.affiliation: From the University of Western Australia Centre for Ophthalmology and Visual Science and Lions Eye Institute(Yazar, Hewitt, Forward, McKnight, Tan, Mackey) and the Telethon Institute for Child Health Research (Mountain), Perth, Western Australia, Australia.
authors.forename: Jenny A
authors.initials: JA
authors.lastname: Mountain
authors.affiliation: From the University of Western Australia Centre for Ophthalmology and Visual Science and Lions Eye Institute(Yazar, Hewitt, Forward, McKnight, Tan, Mackey) and the Telethon Institute for Child Health Research (Mountain), Perth, Western Australia, Australia.
authors.forename: David A
authors.initials: DA
authors.lastname: Mackey
mesh_terms: D057128:Aberrometry; D000293:Adolescent; D003315:Cornea / Q000503:physiopathology; D057108:Corneal Wavefront Aberration / Q000175:diagnosis* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D012029:Refraction, Ocular / Q000502:physiology; D012030:Refractive Errors / Q000175:diagnosis* / Q000503:physiopathology; D014792:Visual Acuity / Q000502:physiology*; D055815:Young Adult