title: A preliminary report on oral fat tolerance test in rhesus monkeys.
abstract: BACKGROUND
  Oral fat tolerance test (OFTT) has been widely used to assess the postprandial lipemia in human beings, but there is few studies concerning OFTT in nonhuman primates. This study is designed to explore the feasibility of OFTT in rhesus monkeys.
  
  
  METHODS
  In a cross-over study, a total of 8 adult female rhesus monkeys were fed with normal monkey diet (NND), high sugar high fat diet (HHD), and extremely high fat diet (EHD), respectively. Each monkey consumed NND, HHD and EHD respectively, each weighing 60 g. Serial blood samples were collected at 1, 2, 3, 4, 5, and 6 h after ingesting each kind of food. Triglyceride, cholesterol, glucose, and insulin at each time point were measured. The area under the curve of triglyceride (TG-AUC) and triglyceride peak response (TG-PR) were also calculated.
  
  
  RESULTS
  All monkeys ingested 3 kinds of foods within 15 minutes. TG-AUC and TG-PR of HHD group were higher than those of the other two groups. Postprandial triglyceride levels at 2, 3, 4, and 5 hours in HHD group during OFTT were also higher than those in NND and EHD group.
  
  
  CONCLUSIONS
  HHD diet can be used in OFTT for nonhuman primates.
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Qingsu
authors.initials: Q
authors.lastname: Liu
authors.forename: Shiyuan
authors.initials: S
authors.lastname: Wei
authors.forename: Yu Alex
authors.initials: YA
authors.lastname: Zhang
authors.affiliation: Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. fyuee@hotmail.com.
authors.forename: Feng
authors.initials: F
authors.lastname: Yue
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose; D002784:Cholesterol / Q000097:blood; D003938:Diagnostic Techniques, Digestive System; D059305:Diet, High-Fat; D004041:Dietary Fats / Q000008:administration & dosage*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D008253:Macaca mulatta; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol