title: Plasma levels of omentin-1 and visfatin in senile patients with coronary heart disease and heart failure.
abstract: OBJECTIVE
  To investigate the alteration of plasma levels of omentin-1 and visfatin in elderly patients with coronary heart disease (CHD) and heart failure.
  
  
  METHODS
  Plasma omentin-1 and visfatin levels were measured in 90 subjects (29 stable angina pectoris (SAP) cases, 30 unstable angina pectoris (UAP) cases and 31 age- and sex-matched healthy controls (age ≥ 60 years) by enzyme-linked immunosorbent assay methods. According to the New York Heart Association classification, 59 CHDs were divided into three groups: functional I class, 11 cases; functional II/III class, 36 cases; and functional IV class, 12 cases.
  
  
  RESULTS
  The plasma level of omentin-1 in CHD patients was significantly lower than that of the control group. Omentin-1in SAP group and UAP group were significantly lower compared to the control group (there was no statistical significance between UAP group and SAP group; P >0.05). The plasma level of visfatin in CHD patients was significantly higher than that of the control group. Similarly, visfatin in SAP group and UAP group were all significantly higher compared to the control group, while there was no statistical significance between UAP group, and SAP group. The plasma omentin-1 level was negatively correlated with SBP (r=-0.264, P<0.05), positively correlated with HDL-c level (r=0.271, P<0.05); the plasma visfatin level was positively correlated with TC (r=0.292,P<0.05), negatively correlated with HDL-c level (r=-0.266,P<0.05). There was a negative correlation between plasma omentin-1 and visfatin levels (r=-0.280, P<0.05). Moreover, multiple linear stepwise regression analysis showed that omentin-1 and visfatin levels might be affected by HDL-c level. Logistic regression analysis showed that visfatin could be an independent risk factor of CHD.
  
  
  CONCLUSIONS
  Decreased levels of omentin-1 and increased levels of visfatin may be involved in the occurrence and development of CHD. Omentin-1 and visfatin, independently, may be protective and pro-inflammatory cytokines. Additionally, both omentin-1 and visfatin may be related to lipid metabolism. Visfatin may be an independent risk factor of CHD.
authors.affiliation: School of Nursing, Central South University, Changsha 410013, P.R. China.
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Wang
authors.affiliation: Second Honspital of Xiangya, Central South University, Changsha 410011, P.R. China.
authors.forename: Ling-Zhi
authors.initials: LZ
authors.lastname: Dou
authors.affiliation: School of Nursing, Central South University, Changsha 410013, P.R. China.
authors.forename: Can
authors.initials: C
authors.lastname: Gu
authors.affiliation: Second Honspital of Xiangya, Central South University, Changsha 410011, P.R. China. Electronic address: hnxiaoqingw@sohu.com.
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000787:Angina Pectoris / Q000097:blood / Q000453:epidemiology; D003327:Coronary Disease / Q000097:blood* / Q000453:epidemiology; D016207:Cytokines / Q000097:blood*; D058851:GPI-Linked Proteins / Q000097:blood; D006333:Heart Failure / Q000097:blood* / Q000453:epidemiology; D006801:Humans; D037102:Lectins / Q000097:blood*; D016014:Linear Models; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D054409:Nicotinamide Phosphoribosyltransferase
keywords: Coronary heart disease; NYHA class; Omentin-1; Stable angina pectoris; Unstable angina pectoris; Visfatin