title: [Role of procalcitonin in the diagnosis of early neonatal infection].
abstract: OBJECTIVE
  To limit the regulation of antibiotherapy in neonatal early infections by improving the tracking and the diagnosis of infected newborns.
  
  
  METHODS
  First part: analysis of procalcitonin (PCT) in the cord. Method of tracking: 87 cases. Cut-off PCT=0.5 ng/mL. Measurement of CRP at 24 h if PCT>0.5 ng/mL. Second part: analysis of the PCT between 4 h and 6 h in the event of infectious risk; 47 cases over 6 months. Cut-off PCT=2 ng/mL. Measurement of CRP at 12 h and/or 24 h.
  
  
  RESULTS
  In 2012, there were 10 antibiotherapies prescribed per 1000 births versus 30/1000 in 2011. A reduction in two thirds of the indications was seen.
  
  
  CONCLUSIONS
  Markers of inflammation, i.e., the PCT (good specificity and good negative predictive value from 0 to 6 h of life) and CRP (good sensitivity and good positive predictive value from 12 to 24 of life) should be combined in time.
authors.affiliation: Service de pédiatrie-néonatologie, centre hospitalier Martigues-Les-Rayettes, 3, boulevard des Rayettes, BP 50248, 13698 Martignes cedex, France. Electronic address: bernard.faverge@ch-martigues.fr.
authors.forename: B
authors.initials: B
authors.lastname: Faverge
authors.affiliation: Service de pédiatrie-néonatologie, centre hospitalier Martigues-Les-Rayettes, 3, boulevard des Rayettes, BP 50248, 13698 Martignes cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Attou
authors.affiliation: Service de pédiatrie-néonatologie, centre hospitalier Martigues-Les-Rayettes, 3, boulevard des Rayettes, BP 50248, 13698 Martignes cedex, France.
authors.forename: A
authors.initials: A
authors.lastname: Cahérec
authors.affiliation: Service de pédiatrie-néonatologie, centre hospitalier Martigues-Les-Rayettes, 3, boulevard des Rayettes, BP 50248, 13698 Martignes cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Dookna
authors.affiliation: Service de pédiatrie-néonatologie, centre hospitalier Martigues-Les-Rayettes, 3, boulevard des Rayettes, BP 50248, 13698 Martignes cedex, France.
authors.forename: J
authors.initials: J
authors.lastname: Forler
authors.affiliation: Service de pédiatrie-néonatologie, centre hospitalier Martigues-Les-Rayettes, 3, boulevard des Rayettes, BP 50248, 13698 Martignes cedex, France.
authors.forename: I
authors.initials: I
authors.lastname: Ticus
authors.affiliation: Laboratoire de biologie, CH Martigues-Les-Rayettes, 13500 Martigues, France.
authors.forename: P
authors.initials: P
authors.lastname: Desvignes
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D004363:Drug Utilization / Q000706:statistics & numerical data; D004756:Enterobacteriaceae Infections / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000175:diagnosis* / Q000188:drug therapy; D011498:Protein Precursors / Q000097:blood*; D013290:Streptococcal Infections / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy; D013292:Streptococcus agalactiae
chemical_list: D000900:Anti-Bacterial Agents; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide