title: Effects of light on metalloporphyrin-treated newborn mice.
abstract: Zinc protoporphyrin (ZnPP) is a promising metalloporphyrin with sufficient potency, but has poor solubility and is not absorbed well orally. Intragastric administration of ZnPP microparticles (30 μmol/kg) to 3-day-old mice resulted in a twofold increase in potency and no signs of phototoxicity.
  
  
  CONCLUSIONS
  The use of polymeric particulate delivery systems can improve the stability and enhance intestinal absorption of ZnPP, while retaining HO inhibitory potency without photosensitising effects, and thus is potentially useful in treating neonatal hyperbilirubinemia.
authors.affiliation: Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. rjwong@stanford.edu.
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Wong
authors.forename: Stephanie
authors.initials: S
authors.lastname: Schulz
authors.forename: Cecilia
authors.initials: C
authors.lastname: Espadas
authors.forename: Hendrik J
authors.initials: HJ
authors.lastname: Vreman
authors.forename: Jayakumar
authors.initials: J
authors.lastname: Rajadas
authors.forename: David K
authors.initials: DK
authors.lastname: Stevenson
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors; D051556:Hyperbilirubinemia, Neonatal / Q000188:drug therapy* / Q000517:prevention & control; D008027:Light / Q000009:adverse effects*; D008665:Metalloporphyrins / Q000627:therapeutic use*; D051379:Mice; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011524:Protoporphyrins / Q000627:therapeutic use*
chemical_list: D004791:Enzyme Inhibitors; D008665:Metalloporphyrins; D017319:Photosensitizing Agents; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D006419:Heme Oxygenase (Decyclizing)
keywords: Bilirubin; Heme oxygenase; Metalloporphyrin; Neonatal jaundice; Phototoxicity