title: The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese.
abstract: BACKGROUND
  Epidemiologic studies on mild cognitive impairment (MCI) are limited in China.
  
  
  METHODS
  Using a multistage cluster sampling design, a total of 10,276 community residents (6096 urban, 4180 rural) aged 65 years or older were evaluated and diagnosed with normal cognition, MCI, or dementia. MCI was further categorized by imaging into MCI caused by prodromal Alzheimer's disease (MCI-A), MCI resulting from cerebrovascular disease (MCI-CVD), MCI with vascular risk factors (MCI-VRF), and MCI caused by other diseases (MCI-O).
  
  
  RESULTS
  The prevalences of overall MCI, MCI-A, MCI-CVD, MCI-VRF, and MCI-O were 20.8% (95% confidence interval [CI] = 20.0-21.6%), 6.1% (95% CI = 5.7-6.6%), 3.8% (95% CI = 3.4-4.2%), 4.9% (95% CI = 4.5-5.4%), and 5.9% (95% CI = 5.5-6.4%) respectively. The rural population had a higher prevalence of overall MCI (23.4% vs 16.8%, P < .001).
  
  
  CONCLUSIONS
  The prevalence of MCI in elderly Chinese is higher in rural than in urban areas. Vascular-related MCI (MCI-CVD and MCI-VRF) was most common.
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China. Electronic address: jjp@ccmu.edu.cn.
authors.forename: Jianping
authors.initials: J
authors.lastname: Jia
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Aihong
authors.initials: A
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Cuibai
authors.initials: C
authors.lastname: Wei
authors.affiliation: Department of Computer Science, University of Otago, Dunedin, New Zealand.
authors.forename: Xiangfei
authors.initials: X
authors.lastname: Jia
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Neurology, Fu Xing Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.affiliation: Evidence-Based Medicine Center, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Wu
authors.affiliation: Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.
authors.forename: Vincent
authors.initials: V
authors.lastname: Mok
authors.affiliation: McGill Center for Studies in Aging, McGill University, Montreal, Quebec, Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Gauthier
authors.affiliation: Department of Geriatrics, Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong Province, People's Republic of China.
authors.forename: Muni
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Neurology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou Province, People's Republic of China.
authors.forename: Lan
authors.initials: L
authors.lastname: Chu
authors.affiliation: Department of Neurology, Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, People's Republic of China.
authors.forename: Youlong
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Neurology, First Hospital of Jilin University, Changchun, Jinlin Province, People's Republic of China.
authors.forename: Chunkui
authors.initials: C
authors.lastname: Zhou
authors.affiliation: Department of Neurology, Fourth Hospital of Jilin University, Changchun, Jinlin Province, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Neurology, Beijing Geriatric Hospital, Beijing, People's Republic of China.
authors.forename: Weishan
authors.initials: W
authors.lastname: Wang
authors.affiliation: National Center for Chronic and Noncommunicable Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Peng
authors.initials: P
authors.lastname: Yin
authors.affiliation: National Center for Chronic and Noncommunicable Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Nan
authors.initials: N
authors.lastname: Hu
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Xiumei
authors.initials: X
authors.lastname: Zuo
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Song
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Qin
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Liyong
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.affiliation: Department of Neurology, Tongren Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Longfei
authors.initials: L
authors.lastname: Jia
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Juexian
authors.initials: J
authors.lastname: Song
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xing
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Peijie
authors.initials: P
authors.lastname: Yang
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Yuemei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Yuchen
authors.initials: Y
authors.lastname: Qiao
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Department of Neurology, Beijing Geriatric Hospital, Beijing, People's Republic of China.
authors.forename: Jihui
authors.initials: J
authors.lastname: Lv
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, People's Republic of China.
authors.forename: Xiumin
authors.initials: X
authors.lastname: Dong
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D044466:Asian People; D002561:Cerebrovascular Disorders / Q000453:epidemiology; D016009:Chi-Square Distribution; D060825:Cognitive Dysfunction / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012189:Retrospective Studies; D012307:Risk Factors
keywords: Etiological subtypes; Mild cognitive impairment; Prevalence; Risk factors