title: Does melatonin ameliorate neurological changes associated with Alzheimer's disease in ovariectomized rat model?
abstract: This study aimed to elucidate the mechanisms of melatonin to manage neurological damage in Alzheimer's disease (AD) induced in ovariectomized rats. Forty adult female rats were enrolled in our study and were classified as; gonad intact control, ovariectomized control group, ovariectomized rats received melatonin, ovariectomized rats injected with AlCl3 to induce AD and AD-induced rats treated with melatonin. Hydrogen peroxide (H2O2), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), acetylcholinesterase (AchE) and acetylcholine (Ach) were estimated in the brain tissues of the different groups. Treatment of AD-induced rats with melatonin produced marked improvement in the most studied biomarkers which was confirmed by histological investigation of the brain. In Conclusion, melatonin significantly ameliorates the neurodegeneration characteristic of AD in experimental animal model due to its antioxidant, antiapoptotic, neurotrophic and anti-amyloidogenic activities.
authors.affiliation: Hormones Department, Medical Research Division, National Research Centre, Dokki, Cairo, 12622 Egypt.
authors.forename: Hanaa H
authors.initials: HH
authors.lastname: Ahmed
authors.affiliation: Hormones Department, Medical Research Division, National Research Centre, Dokki, Cairo, 12622 Egypt.
authors.forename: Selim F
authors.initials: SF
authors.lastname: Estefan
authors.affiliation: Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt.
authors.forename: Ehab M
authors.initials: EM
authors.lastname: Mohamd
authors.affiliation: Pathology Department, National Research Centre, Dokki, Cairo, Egypt.
authors.forename: Abd El-Razik H
authors.initials: Ael-R
authors.lastname: Farrag
authors.affiliation: Hormones Department, Medical Research Division, National Research Centre, Dokki, Cairo, 12622 Egypt.
authors.forename: Rania S
authors.initials: RS
authors.lastname: Salah
keywords: Alzheimer’s disease; Anti-amyloidogenesis; Melatonin; Neurogenesis; Rats