title: JAK-STAT signaling and myocardial glucose metabolism.
abstract: JAK-STAT signaling occurs in virtually every tissue of the body, and so does glucose metabolism. In this review, we summarize the regulation of glucose metabolism in the myocardium and ponder whether JAK-STAT signaling participates in this regulation. Despite a paucity of data directly pertaining to cardiac myocytes, we conclude that JAK-STAT signaling may contribute to the development of insulin resistance in the myocardium in response to various hormones and cytokines.
authors.affiliation: Division of Endocrinology, Diabetology and Nutrition; University of Geneva School of Medicine; Geneva, Switzerland.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Frias
authors.affiliation: Division of Cardiology; Department of Medical Specialties; University of Geneva School of Medicine; Geneva, Switzerland.
authors.forename: Christophe
authors.initials: C
authors.lastname: Montessuit
keywords: JAK; Janus kinase; SOCS; STAT; cardiac myocytes; glucose metabolism; insulin; insulin resistance; myocardium; signal transducer and activator of transcription; suppressor of cytokine signaling