title: Static blood flow autoregulation in the optic nerve head in normal and experimental glaucoma.
abstract: OBJECTIVE
  To characterize the static blood flow autoregulation in the optic nerve head (ONH), and to investigate its role in hemodynamic changes in experimental glaucoma (EG).
  
  
  METHODS
  Unilateral elevation of intraocular pressure (IOP) was induced in 15 adult rhesus macaques by laser treatment to the trabecular meshwork. Prior to and after laser treatment, retinal nerve fiber layer thickness (RNFLT) was assessed, biweekly, by spectral-domain optical coherence tomography. Optic nerve head static autoregulation was assessed by determining the percentage blood flow (BF) change after the IOP was acutely increased from 10 to 30, 40, or 50 mm Hg manometrically, utilizing a laser speckle flowgraphy device.
  
  
  RESULTS
  Postlaser IOP (measured during average 7.7 ± 2.6 months) was 20.2 ± 5.9 mm Hg in EG eyes and 12.3 ± 2.6 mm Hg in control eyes (P < 0.0001). Retinal nerve fiber layer thickness was reduced by 33 ± 22% of the baseline values (P < 0.001) on average in EG eyes and by 0.4 ± 2.3% in control eyes (P > 0.05). The ONH BF remained at a constant level within a range of ocular perfusion pressure (OPP), 41 mm Hg and above. The autoregulation curves, created by all 723 tests in control and 352 tests in EG, were not significantly different (P = 0.71).
  
  
  CONCLUSIONS
  Optic nerve head BF in normal nonhuman primate (NHP) eyes is effectively regulated within a range of OPP approximately 41 mm Hg and above. Chronic IOP elevation causes no remarkable change to the static autoregulation within the ONH of EG eyes.
authors.affiliation: Devers Eye Institute, Legacy Research Institute, Portland, Oregon.
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Claude F
authors.initials: CF
authors.lastname: Burgoyne
authors.forename: Grant
authors.initials: G
authors.lastname: Cull
authors.forename: Simon
authors.initials: S
authors.lastname: Thompson
authors.forename: Brad
authors.initials: B
authors.lastname: Fortune
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D004195:Disease Models, Animal; D005260:Female; D005901:Glaucoma / Q000503:physiopathology*; D006706:Homeostasis / Q000502:physiology*; D007429:Intraocular Pressure / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D009412:Nerve Fibers / Q000473:pathology; D009898:Optic Disk / Q000098:blood supply*; D012039:Regional Blood Flow / Q000502:physiology; D012165:Retinal Ganglion Cells / Q000473:pathology; D041623:Tomography, Optical Coherence
keywords: autoregulation; experimental glaucoma; intraocular pressure; ocular perfusion pressure