title: Complex cellular composition of solitary fibrous tumor of the prostate.
abstract: Solitary fibrous tumors (SFTs) of the prostate are a rare type of spindle cell neoplasm that can demonstrate either a benign or malignant phenotype. SFTs represent a clinical challenge along with other spindle cell lesions of the prostate in terms of both diagnosis and treatment. The present study shows, for the first time, that SFTs of the prostate and other organs can comprise a mixed population of fibroblast, myofibroblast, and smooth muscle cell types. The highly proliferative component demonstrated a fibroblastic phenotype that readily underwent myofibroblast differentiation on exposure to profibrotic stimuli. Consistent with other recent studies, the prostatic SFTs demonstrated NAB2-STAT6 gene fusions that were also present in the fibroblast, myofibroblast, and smooth muscle cell types of the SFT. The results of these studies suggest that benign and malignant prostatic tumors of mesenchymal origin may be distinguished at the molecular and cellular levels, and that delineation of such defining characteristics may help elucidate the etiology and prognosis of such tumors.
authors.affiliation: Department of Biology, The University of Massachusetts Boston, Boston, Massachusetts; Center for Personalized Cancer Therapy, The University of Massachusetts Boston, Boston, Massachusetts.
authors.forename: Mehrnaz
authors.initials: M
authors.lastname: Gharaee-Kermani
authors.affiliation: Michigan Center for Translational Pathology, The University of Michigan School of Medicine, Ann Arbor, Michigan.
authors.forename: Rohit
authors.initials: R
authors.lastname: Mehra
authors.affiliation: Michigan Center for Translational Pathology, The University of Michigan School of Medicine, Ann Arbor, Michigan.
authors.forename: Dan R
authors.initials: DR
authors.lastname: Robinson
authors.affiliation: Department of Urology, The University of Michigan School of Medicine, Ann Arbor, Michigan.
authors.forename: John T
authors.initials: JT
authors.lastname: Wei
authors.affiliation: Department of Biology, The University of Massachusetts Boston, Boston, Massachusetts; Center for Personalized Cancer Therapy, The University of Massachusetts Boston, Boston, Massachusetts. Electronic address: Jill.Macoska@umb.edu.
authors.forename: Jill A
authors.initials: JA
authors.lastname: Macoska
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D049109:Cell Proliferation; D003094:Collagen / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000378:metabolism; D011379:Prognosis; D011467:Prostate / Q000473:pathology; D011471:Prostatic Neoplasms / Q000473:pathology*; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D050800:STAT6 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D054364:Solitary Fibrous Tumors / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; C491000:NAB2 protein, human; D015514:Oncogene Proteins, Fusion; D012097:Repressor Proteins; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; D003094:Collagen