title: [Synthesis and photodynamic anticancer activity of silicon phthalocyanine axially modified by nucleoside derivatives].
abstract: A new axially modified silicon phthalocyanine, di [5'-(2', 3'-O-isopropyl)-5-methyl cytidineoxy] silicon phthalocyanine (SiPcG), was prepared and characterized by 1H NMR and HRMS. This compound is essentially nonaggregated in N,N-dimethyformamide and 1% cremophor EL aqueous solution. It shows a Qband at 676 nm and fluorescence emission at 685 nm in DMF, and exhibits a Q-band at 679 nm and fluorescence emission at 689 nm in 1% cremophor EL aqueous solution. The SiPcG shows a high photodynamic activity against human hepatoma cells HepG2 with an IC50 value down to 7.8 x 10(-8) mol x L(-1). Fluorescence confocal microscopy study indicated that the SiPcG locates preferentially in the mitochondria of cells. The research results show that the SiPcG is highly potential as a new anti-cancer photosensitizer.
authors.affiliation: College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China. shxm830315@163.com
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Shen
authors.affiliation: College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China.
authors.forename: Bi-Yuan
authors.initials: BY
authors.lastname: Zheng
authors.affiliation: College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China.
authors.forename: Han-Hui
authors.initials: HH
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China.
authors.forename: Jian-Dong
authors.initials: JD
authors.lastname: Huang
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D056945:Hep G2 Cells / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008113:Liver Neoplasms; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D009705:Nucleosides / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D009705:Nucleosides; D017646:Organosilicon Compounds; D017319:Photosensitizing Agents; C082854:silicon phthalocyanine