title: Persistent neurogenic bladder dysfunction due to infantile botulism.
abstract: We present a child, 5 months of age, diagnosed with infantile botulism, showing the signs of neurogenic bladder dysfunction. The patient presented with progressive muscle weakness, hypotonia, suckling and swallowing problems and absent peripheral reflexes at clinical examination. Botulinum neurotoxin type A was detected in her serum, confirming the diagnosis. Starting at day 6, the girl presented with a urinary retention initially necessitating free bladder drainage and subsequently intermittent catheterisation. After 6 weeks in intensive care, the patient recovered but the bladder underactivity persisted. Four months following recovery, a urodynamic evaluation was performed, showing a near normal detrusor activity and normal bladder emptying, and the catheterisation was ceased. At 6 months, the girl was diagnosed with a urinary tract infection and bladder emptying problems, which persisted, and clean intermittent catheterisation was started. The final urodynamic evaluation, a year and a half after her initial presentation, revealed a normal detrusor activity and an adequate bladder emptying.
authors.affiliation: Department of Pediatrics, Aarhus University Hospital, Aarhus N, Denmark.
authors.forename: Anders
authors.initials: A
authors.lastname: Breinbjerg
authors.forename: Søren
authors.initials: S
authors.lastname: Rittig
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kamperis
mesh_terms: D019274:Botulinum Toxins, Type A / Q000097:blood; D001906:Botulism / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D007223:Infant; D020127:Recovery of Function; D013997:Time Factors; D001750:Urinary Bladder, Neurogenic / Q000382:microbiology* / Q000503:physiopathology; D016055:Urinary Retention / Q000382:microbiology; D014563:Urodynamics
chemical_list: D007136:Immunoglobulins; D019274:Botulinum Toxins, Type A