title: Macromolecular prodrugs of ribavirin: concerted efforts of the carrier and the drug.
abstract: Polymers in tune. Automated parallel polymer synthesis is developed to obtain libraries of macromolecular prodrugs of ribavirin, a broad-spectrum antiviral agent. As many as 10 identified lead polymer conjugates exhibit therapeutic efficacy matching that of the pristine drug and at the same time suppressed the origin of the main side effect of ribavirin.
authors.affiliation: Department Department of Chemistry, Aarhus University, Aarhus, C 8000, Denmark.
authors.forename: Anton A A
authors.initials: AA
authors.lastname: Smith
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Wohl
authors.forename: Mille B L
authors.initials: MB
authors.lastname: Kryger
authors.forename: Natasha
authors.initials: N
authors.lastname: Hedemann
authors.forename: Carlos
authors.initials: C
authors.lastname: Guerrero-Sanchez
authors.forename: Almar
authors.initials: A
authors.lastname: Postma
authors.forename: Alexander N
authors.initials: AN
authors.lastname: Zelikin
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002850:Chromatography, Gel; D055808:Drug Discovery; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008970:Molecular Weight; D009569:Nitric Oxide / Q000032:analysis / Q000378:metabolism; D011355:Prodrugs / Q000737:chemistry* / Q000494:pharmacology*; D012254:Ribavirin / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D011355:Prodrugs; D009569:Nitric Oxide; D012254:Ribavirin
keywords: drug delivery; high throughput screening; inflammation; polymers; prodrugs