title: [Immunohistochemical profile of angiogenesis in the thyroid gland in various thyroid diseases].
abstract: The purpose of the study - to determine the feature of the vascular endothelial growth factor (VEGF) and thyroid-stimulating hormone (TSH) expression in the thyroid gland (TG) in various thyroid diseases. Material - thyroid tissue (operative material) with histologically confirmed diagnosis: 10 - follicular adenoma, 17 - multinodular goiter, 8 - thyroiditis Hashimoto, 8 - papillary carcinoma, 10 - intact (normal) thyroid samples (forensic autopsy). The immunohistochemical study of the material showed the following results: the increase of the Hürtle cells population 40 % or more indicates a hyperthyroidism tendency despite TSH+ receptor status. Under the thyroid pathology TSH and VEGF expression appears in thyrocytes and also in microvascular endothelial cells. VEGF expression is below the norm in the Hashimoto thyroiditis. VEGF is involved not only in angiogenesis, but in pathophysiological shifts in thyroid tissue. Microvessel density (MVD) and TSH positive receptor status under the thyroid pathology testify the absence of the endothelial cells transformation, however, this index can not serve as a biopothential prognostic marker of thyroid disease.
authors.forename: N Z
authors.initials: NZ
authors.lastname: Rurua
authors.forename: L E
authors.initials: LE
authors.lastname: Gogiashvili
authors.forename: Z G
authors.initials: ZG
authors.lastname: Tsagareli
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D001344:Autopsy; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D006044:Goiter, Nodular / Q000378:metabolism / Q000473:pathology; D050031:Hashimoto Disease / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009389:Neovascularization, Pathologic; D013961:Thyroid Gland / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D013972:Thyrotropin / Q000096:biosynthesis* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D013972:Thyrotropin