title: Interactions between the intestinal microbiota and innate lymphoid cells.
abstract: The mammalian intestine must manage to contain 100 trillion intestinal bacteria without inducing inappropriate immune responses to these microorganisms. The effects of the immune system on intestinal microorganisms are numerous and well-characterized, and recent research has determined that the microbiota influences the intestinal immune system as well. In this review, we first discuss the intestinal immune system and its role in containing and maintaining tolerance to commensal organisms. We next introduce a category of immune cells, the innate lymphoid cells, and describe their classification and function in intestinal immunology. Finally, we discuss the effects of the intestinal microbiota on innate lymphoid cells.
authors.affiliation: Department of Microbiology and Immunobiology; Harvard Medical School; Boston, MA USA.
authors.forename: Vincent L
authors.initials: VL
authors.lastname: Chen
authors.affiliation: Department of Microbiology and Immunobiology; Harvard Medical School; Boston, MA USA.
authors.forename: Dennis L
authors.initials: DL
authors.lastname: Kasper
mesh_terms: D000818:Animals; D001419:Bacteria / Q000254:growth & development / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007422:Intestines / Q000276:immunology* / Q000382:microbiology*; D008214:Lymphocytes / Q000276:immunology*; D064307:Microbiota
keywords: Bacteroides fragilis; innate lymphoid cell; intestinal immunity; lymphoid tissue inducer cell; microbiota; polysaccharide A