title: Locally extensive angio-invasive Scedosporium prolificans infection following resection for squamous cell lung carcinoma.
abstract: We report a case of Scedosporium prolificans infection in a patient following surgery for squamous cell lung carcinoma. Combination therapy with voriconazole and terbinafine was commenced for intrathoracic infection and mycotic vasculitis. In spite of antifungal treatment, he developed culture-positive sternal and rib osteomyelitis four months later. Scedosporiosis is not commonly reported in patients with solid organ malignancies, and this case highlights its aggressive nature and propensity for direct local invasion.
authors.affiliation: Austin Centre for Infection Research, Austin Health, Heidelberg, VIC 3084, Australia ; Department of Medicine, University of Melbourne, Parkville, VIC 3052, Australia.
authors.forename: Natasha E
authors.initials: NE
authors.lastname: Holmes
authors.affiliation: Austin Centre for Infection Research, Austin Health, Heidelberg, VIC 3084, Australia.
authors.forename: Janine M
authors.initials: JM
authors.lastname: Trevillyan
authors.affiliation: Mycology Unit, SA Pathology, Women's and Children's Hospital, North Adelaide, SA 5006, Australia.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Kidd
authors.affiliation: Department of Anatomical Pathology, Austin Pathology, Heidelberg, VIC 3084, Australia.
authors.forename: Trishe Y-M
authors.initials: TY
authors.lastname: Leong
keywords: Disseminated; Scedosporium prolificans; Terbinafine; Therapeutic drug monitoring; Voriconazole