title: A new inositol triester from Taraxacum mongolicum.
abstract: One new inositol triester, 4,5,6-tri-O-p-hydroxyphenylacetyl-chiro-inositol (1), was isolated from the ethanolic extract of Taraxacum mongolicum, along with two known compounds, 11β,13-dihydrotaraxinic acid (2) and taraxinic acid β-d-glucopyranosyl ester (3). The isolates were tested for their anti-hepatitis B virus (HBV) activities; 11β,13-dihydrotaraxinic acid (2) exhibited an IC50 value of 0.91 mM inhibiting the secretion of the HBV surface antigen and an IC50 value of 0.34 mM inhibiting the secretion of the HBV e antigen using HBV transfected Hep G2.2.15 cell line.
authors.affiliation: a School of Pharmaceutical Science, Zhengzhou University , Ke Xue Da Dao 100, Zhengzhou 450001 , People's Republic of China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Liu
authors.forename: Nenling
authors.initials: N
authors.lastname: Zhang
authors.forename: Mengqi
authors.initials: M
authors.lastname: Liu
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056945:Hep G2 Cells; D006515:Hepatitis B virus / Q000187:drug effects / Q000276:immunology; D006801:Humans; D020128:Inhibitory Concentration 50; D007294:Inositol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification; D031205:Taraxacum / Q000737:chemistry*
chemical_list: C554308:11beta,13-dihydrotaraxinic acid; C000591439:4,5,6-tri-O-p-hydroxyphenylacetyl-chiro-inositol; D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; D007294:Inositol