title: [Effects of shuang shen tong guan decoction on the blood flow dynamics in rat model with myocardial infarction].
abstract: OBJECTIVE
  To research the effects of Shuang Shen Tong Guan Decoction (SSTGD) on hemodynamics in rats with acute myocardial infarction (AMI).
  
  
  METHODS
  SD rats were divided into sham operation group,model group, SSTGD low-dose group (2.5 g/kg), SSTGD middle-dose group (5 g/kg) and SSTGD high-dose group (7.5 g/kg). The levels of HR, MAP, LVSP, LVEDP, LVdp/ dt(max) and LVdp/dt(min) were detected by PowerLab at 0, 15, 30, 60, 90, 120, 180 min after administration.
  
  
  RESULTS
  Compared with the sham operated group, the levels of HR, MAP were increased, the levels of LVSP, LVEDP, LVdp/dt(max) and LVdp/dt(min) were reduced at each detected point in model group, the difference was significant (P < 0.05). Compared with the model group, HR and MAP were decreased in SSTGD low-dose group, SSTGD middle-dose group and SSTGD high-dose group after 15 min; LVSP, LVEDP, LVdp/dt(max) and LVdp/dt(min) were higher, there was significantly difference (P < 0.05). Compared with SSTGD low-dose group and SSTGD middle-dose group, the difference of LVSP, LVEDP, LVdp/dt(max) and LVdp/dt(min) was statistically significant in SSTGD high-dose group (P < 0.05).
  
  
  CONCLUSIONS
  SSTGD can improve cardiac function by increasing heart stroke volume, decreasing cardiac oxygen consumption and total peripheral vascular resistance.
authors.affiliation: Cardio-Cerebrovascular Diseases Institute, Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China. wayoga3ng@hotmail.com
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Wang
authors.affiliation: Cardio-Cerebrovascular Diseases Institute, Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhong
authors.affiliation: Cardio-Cerebrovascular Diseases Institute, Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China.
authors.forename: Yuan-Wang
authors.initials: YW
authors.lastname: Yu
authors.affiliation: Cardio-Cerebrovascular Diseases Institute, Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Zheng
authors.affiliation: Cardio-Cerebrovascular Diseases Institute, Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China.
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Shang
authors.affiliation: Cardio-Cerebrovascular Diseases Institute, Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Qi
authors.affiliation: Cardio-Cerebrovascular Diseases Institute, Shaanxi University of Traditional Chinese Medicine, Xianyang 712000, China.
authors.forename: Jin-Zhi
authors.initials: JZ
authors.lastname: You
mesh_terms: D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D005894:Panax / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D027561:Salvia miltiorrhiza / Q000737:chemistry; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology
chemical_list: D004365:Drugs, Chinese Herbal; D014665:Vasodilator Agents