title: Isolated limb perfusion with melphalan for melanoma.
abstract: Isolated limb perfusion with melphalan is a well-established and effective treatment for inoperable melanoma metastases of the extremities, with an overall response rate of 80% and a complete response rate of 54%. The surgical technique is complex and serious morbidity can occur, but with attention to detail major side effects can be kept to a minimum. This article reviews the technique, results and other aspects of this sophisticated form of treatment.
authors.affiliation: Melanoma Institute Australia, North Sydney, NSW, Australia.
authors.forename: Omgo E
authors.initials: OE
authors.lastname: Nieweg
authors.forename: Bin B R
authors.initials: BB
authors.lastname: Kroon
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D006801:Humans; D008545:Melanoma / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008558:Melphalan / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic
chemical_list: D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan
keywords: limb perfusion; metastases; regional chemotherapy; review