title: [Association of Cystatin C and metabolic syndrome].
abstract: OBJECTIVE
  To explore the correlation between serum levels of Cystatin C and metabolic syndrome.
  
  
  METHODS
  This study was randomly conducted in 506 persons, including 191 patients with metabolic syndrome (MS), 210 with metabolic disorder (MD) and 105 persons in normal control (NC) group. According to serum levels of Cys C, the clinical data were also divided into 3 groups of lower tertile (T1, n = 165), middle tertile (T2, n = 172) and upper tertile (T3, n = 169). Body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), fasting plasma glucose (FPG), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), high density lipoprotein (HDL), creatinine (Cr), estimated glomerular filtration rate (eGFR), microalbuminuria (MAU), systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were measured and their mutual relations evaluated.
  
  
  RESULTS
  Statistically significant differences (all P < 0.01) existed among T1, T2 and T3 groups in the mean values of BMI, waist circumference, WHR, FPG, LDL-C, TG, Cr, eGFR, MAU, SBP, DBP and PP. As tertile levels of Cys C increased, MS morbidity rates became all remarkably augmented (P < 0.01). The MS component scores had significant statistical differences among the patients of T1, T2 and T3 groups (P < 0.01). As the MS component scores increased, the level of Cys C rose in these patients. The higher MS marks were, the higher serum concentration of Cys C was in these patients. The plasma concentration of Cys C in MS patients was closely related with WC, LDL-C, FBG and blood pressure (all P < 0.05), not related with TG levels and negatively correlated with HDL-C levels (r = -0.352, P = 0.01). WC, Cys C, LDL-C, MAU and PP were significantly associated with MS. And the value of OR between Cys C and MS was 2.943 (95% CI 1.276-3.914).
  
  
  CONCLUSIONS
  Cys C is significantly associated with MS. As MS scores rise, the level of Cys C increases.
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Shandong University, Jinan 250033, China. Email: cardiac@163.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Shandong University, Jinan 250033, China.
authors.forename: Shu-jian
authors.initials: SJ
authors.lastname: Sui
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Shandong University, Jinan 250033, China.
authors.forename: Dong-ling
authors.initials: DL
authors.lastname: Xu
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Shandong University, Jinan 250033, China.
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Xing
authors.affiliation: Department of Cardiology, Second Affiliated Hospital, Shandong University, Jinan 250033, China.
authors.forename: Cai-xia
authors.initials: CX
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D055316:Cystatin C