title: Subclinical Breast Cancer: Minimally Invasive Approaches. Our Experience with Percutaneous Radiofrequency Ablation vs. Cryotherapy.
abstract: BACKGROUND
  The aim of this study was to compare the efficacy of radiofrequency ablation vs. cryoablation in the treatment of early breast cancer.
  
  
  METHODS
  80 women (mean age 73 ± 5 years) with early breast cancer were retrospectively evaluated. 40 patients underwent cryoablation and 40 patients underwent radiofrequency ablation, both with sentinel lymph node excision. Tumor volume and histopatological data were compared by means of postprocedural 3.0-T magnetic resonance imaging (MRI). 30-45 days after the percutaneous ablation, all patients underwent surgical resection of the tumor. The mean follow-up was 18 months without any local recurrences.
  
  
  RESULTS
  Both techniques allow good correlation with histopathological data. In 75 patients (93.8%) we observed complete necrosis; in 5 cases there was residual disease in the postprocedural MRI and postoperative histological examination. There was a good correlation between MRI volume and histologic samples. Cosmetic results were good in all patients but 2.
  
  
  CONCLUSIONS
  Both percutaneous radiofrequency ablation and cryotherapy are minimally invasive techniques with a good clinical and cosmetic outcome in selected cases. MRI examination is an ideal method to assess breast neoplasms in terms of quality and quantity as well as residual tumor extent after percutaneous ablation. Cryotherapy is the preferred method because of the analgesic effect of freezing with better patients compliance.
authors.affiliation: Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Italy.
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Manenti
authors.affiliation: Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Italy.
authors.forename: Angela L
authors.initials: AL
authors.lastname: Scarano
authors.affiliation: Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Italy.
authors.forename: Chiara A
authors.initials: CA
authors.lastname: Pistolese
authors.affiliation: Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Perretta
authors.affiliation: Department of Anatomical Pathology, Policlinico Tor Vergata, Rome, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Bonanno
authors.affiliation: Department of Anatomical Pathology, Policlinico Tor Vergata, Rome, Italy.
authors.forename: Augusto
authors.initials: A
authors.lastname: Orlandi
authors.affiliation: Department of Diagnostic Imaging and Interventional Radiology, Molecular Imaging and Radiotherapy, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Simonetti
keywords: Breast cancer; Cryoablation; MRI; Minimally invasive techniques; Percutaneous ablation; Radiofrequency ablation