title: Selective alkylation and arylation of C-F bond with Grignard reagents.
abstract: Selective alkylation and arylation of the C-F bonds of polyfluoroaryl imines with Grignard reagents were discovered in the absence of metal catalysts. The aldazine-N atom as an anchoring group has a special effect on the regioselectivity of the reaction. The C═N bond addition reaction with Grignard reagents was also explored. A possible mechanism was proposed on the competition between the nucleophilic substitution and addition reaction.
authors.affiliation: School of Chemistry and Chemical Engineering, Key Laboratory of Special Functional Aggregated Materials, Ministry of Education, Shandong University , Shanda Nanlu 27, 250100 Jinan, People's Republic of China.
authors.forename: Faguan
authors.initials: F
authors.lastname: Lu
authors.forename: Hongjian
authors.initials: H
authors.lastname: Sun
authors.forename: Aiqin
authors.initials: A
authors.lastname: Du
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Li