title: A probabilistic and individualized approach for predicting treatment gains: an extension and application to anxiety disordered youth.
abstract: The objective of this study was to extend the probability of treatment benefit method by adding treatment condition as a stratifying variable, and illustrate this extension of the methodology using the Child and Adolescent Anxiety Multimodal Study data. The probability of treatment benefit method produces a simple and practical way to predict individualized treatment benefit based on pretreatment patient characteristics. Two pretreatment patient characteristics were selected in the production of the probability of treatment benefit charts: baseline anxiety severity, measured by the Pediatric Anxiety Rating Scale, and treatment condition (cognitive-behavioral therapy, sertraline, their combination, and placebo). We produced two charts as exemplars which provide individualized and probabilistic information for treatment response and outcome to treatments for child anxiety. We discuss the implications of the use of the probability of treatment benefit method, particularly with regard to patient-centered outcomes and individualized decision-making in psychology and psychiatry.
authors.affiliation: University of Pennsylvania, School of Medicine. Electronic address: rbeidas@upenn.edu.
authors.forename: Rinad S
authors.initials: RS
authors.lastname: Beidas
authors.affiliation: University of Pittsburgh, School of Medicine.
authors.forename: Oliver
authors.initials: O
authors.lastname: Lindhiem
authors.affiliation: Temple University.
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Brodman
authors.affiliation: Temple University.
authors.forename: Anna
authors.initials: A
authors.lastname: Swan
authors.affiliation: Temple University.
authors.forename: Matthew
authors.initials: M
authors.lastname: Carper
authors.affiliation: Temple University.
authors.forename: Colleen
authors.initials: C
authors.lastname: Cummings
authors.affiliation: Temple University.
authors.forename: Philip C
authors.initials: PC
authors.lastname: Kendall
authors.affiliation: Columbia University.
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Albano
authors.affiliation: Columbia University.
authors.forename: Moira
authors.initials: M
authors.lastname: Rynn
authors.affiliation: UCLA.
authors.forename: John
authors.initials: J
authors.lastname: Piacentini
authors.affiliation: UCLA.
authors.forename: James
authors.initials: J
authors.lastname: McCracken
authors.affiliation: Duke Child and Family Study Center.
authors.forename: Scott N
authors.initials: SN
authors.lastname: Compton
authors.affiliation: Duke Child and Family Study Center.
authors.forename: John
authors.initials: J
authors.lastname: March
authors.affiliation: Cornell University.
authors.forename: John
authors.initials: J
authors.lastname: Walkup
authors.affiliation: Johns Hopkins University.
authors.forename: Golda
authors.initials: G
authors.lastname: Ginsburg
authors.affiliation: Johns Hopkins University.
authors.forename: Courtney P
authors.initials: CP
authors.lastname: Keeton
authors.affiliation: University of Pittsburgh, School of Medicine.
authors.forename: Boris
authors.initials: B
authors.lastname: Birmaher
authors.affiliation: University of Pittsburgh, School of Medicine.
authors.forename: Dara
authors.initials: D
authors.lastname: Sakolsky
authors.affiliation: National Institute of Mental Health.
authors.forename: Joel
authors.initials: J
authors.lastname: Sherrill
mesh_terms: D000293:Adolescent; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001008:Anxiety Disorders / Q000188:drug therapy / Q000523:psychology / Q000628:therapy*; D002648:Child; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D020280:Sertraline / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D020280:Sertraline
keywords: child/adolescent anxiety; evidence-based treatment; individualized treatment benefit; patient-centered decision-making; treatment response and outcome