title: Azithromycin Reduces the Production of α-hemolysin and Biofilm Formation in Staphylococcus aureus.
abstract: Staphylococcus aureus causes a broad range of life-threatening diseases in humans. This bacterium produces a large number of extracellular virulence factors that are closely associated with specific diseases which are controlled by quorum sensing. In this study, we show that azithromycin was active against methicillin-resistant Staphylococcus aureus (MRSA) strains with MICs ranged from 32 to 64 μg/mL. Azithromycin at subinhibitory concentration, markedly reduced the production of α-hemolysin at (1/16MIC, 1/8MIC) and biofilm formation at (1/16MIC, 1/8MIC), respectively. The results indicated that sub-inhibitory concentrations of azithromycin decreased the production of α-hemolysin and biofilm formation in MRSA in a dose-dependent manner. Therefore, azithromycin may be useful in the treatment of α-hemolysin producing and biofilm formation MRSA infections.
authors.affiliation: Lishui People's Hospital, Lishui, 323000 China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Gui
authors.affiliation: Lishui People's Hospital, Lishui, 323000 China.
authors.forename: Huafu
authors.initials: H
authors.lastname: Wang
authors.affiliation: Lishui People's Hospital, Lishui, 323000 China.
authors.forename: Ting
authors.initials: T
authors.lastname: Ding
authors.affiliation: Department of Microbiology, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009 China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.affiliation: Department of Microbiology, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009 China.
authors.forename: Xiyi
authors.initials: X
authors.lastname: Zhuang
authors.affiliation: Department of Microbiology, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009 China.
authors.forename: Weihua
authors.initials: W
authors.lastname: Chu
keywords: Azithromycin; Biofilm; Staphylococcus aureus; α-hemolysin