title: Comparision of osteoconductivity of biologic and artificial synthetic hydroxyapatite in experimental mastoid obliteration.
abstract: CONCLUSIONS
  To our knowledge, this is the first in vivo study to address the comparison between biologic hydroxyapatite (BHA) and artificial HA (AHA) materials for mastoid obliteration. From our results, it is believed that BHA has better osteoconductivity than AHA.
  
  
  OBJECTIVE
  The purpose of this study was to compare the osteoconductivity of AHA and BHA in a mastoid obliteration model in rats.
  
  
  METHODS
  BHA and AHA were fabricated. Bulla obliteration was carried out in group A (n = 10, BHA) and group B (n = 10, AHA). The animals were administered fluorescent bone labels for a qualitative evaluation of bone formation. Oxytetracycline hydrochloride was administered at 2 weeks, calcein at 4 weeks, and alizarin red at 8 weeks. The animals were sacrificed at 12 weeks post surgery. They were evaluated by micro-CT and histological investigation.
  
  
  RESULTS
  Neither BHA nor AHA exhibited signs of resorption until 12 weeks of obliteration. However, the accelerated osteoconductive bone formation in the BHA group was better than in the AHA group according to micro-CT and confocal microscopic findings.
authors.affiliation: Department of Otolaryngology, Chonnam National Medical School , Gwangju.
authors.forename: Chul Ho
authors.initials: CH
authors.lastname: Jang
authors.forename: Yong Beom
authors.initials: YB
authors.lastname: Cho
authors.forename: Cheol Hee
authors.initials: CH
authors.lastname: Choi
authors.forename: Yoon Seok
authors.initials: YS
authors.lastname: Jang
authors.forename: Won-Kyo
authors.initials: WK
authors.lastname: Jung
authors.forename: Jong Kook
authors.initials: JK
authors.lastname: Lee
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry; D004195:Disease Models, Animal; D017886:Durapatite / Q000737:chemistry; D008416:Mastoid / Q000601:surgery*; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D011183:Postoperative Complications / Q000473:pathology* / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D055114:X-Ray Microtomography
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D017886:Durapatite