title: Advancements in capillary-assembled microchip (CAs-CHIP) development for multiple analyte sensing and microchip electrophoresis.
abstract: This review describes advancements toward the development of a capillary-assembled microchip (CAs-CHIP) for simultaneous multiple analyte sensing and microchip capillary electrophoresis. Development of such an advanced system relies on several factors such as improving the fluid handling technique, creating new biosensing mechanisms, and integrating different functional capillaries into a single CAs-CHIP system. Furthermore, we provide an overview of various functional capillaries that have been established for valving and biosensing applications such as ions, metabolites, proteins, and enzyme activities. We also highlight future prospects for CAs-CHIP development as related to high-throughput systems, facile fluid handling, and mass production.
authors.affiliation: Graduate School of Engineering, Osaka Prefecture University.
authors.forename: Terence G
authors.initials: TG
authors.lastname: Henares
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Funano
authors.forename: Kenji
authors.initials: K
authors.lastname: Sueyoshi
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Endo
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hisamoto
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D046209:Electrophoresis, Microchip / Q000295:instrumentation*