title: Dietary arsenic exposure with low level of arsenic in drinking water and biomarker: a study in West Bengal.
abstract: The authors investigated association of arsenic intake through water and diet and arsenic level in urine in people living in arsenic endemic region in West Bengal supplied with arsenic-safe water (<50 μg L(-1)). Out of 94 (Group-1A) study participants using water with arsenic level <50 μg L(-1), 72 participants (Group-1B) were taking water with arsenic level <10 μg L(-1). Multiple regressions analysis conducted on the Group-1A participants showed that daily arsenic dose from water and diet were found to be significantly positively associated with urinary arsenic level. However, daily arsenic dose from diet was found to be significantly positively associated with urinary arsenic level in Group-1B participants only, but no significant association was found with arsenic dose from water in this group. In a separate analysis, out of 68 participants with arsenic exposure through diet only, urinary arsenic concentration was found to correlate positively (r = 0.573) with dietary arsenic in 45 participants with skin lesion while this correlation was insignificant (r = 0.007) in 23 participants without skin lesion. Our study suggested that dietary arsenic intake was a potential pathway of arsenic exposure even where arsenic intake through water was reduced significantly in arsenic endemic region in West Bengal. Observation of variation in urinary arsenic excretion in arsenic-exposed subjects with and without skin lesion needed further study.
authors.affiliation: a DNGM Research Foundation , Kolkata , India.
authors.forename: Debendra Nath Guha
authors.initials: DN
authors.lastname: Mazumder
authors.forename: Debasree
authors.initials: D
authors.lastname: Deb
authors.forename: Anirban
authors.initials: A
authors.lastname: Biswas
authors.forename: Chandan
authors.initials: C
authors.lastname: Saha
authors.forename: Ashoke
authors.initials: A
authors.lastname: Nandy
authors.forename: Arabinda
authors.initials: A
authors.lastname: Das
authors.forename: Aloke
authors.initials: A
authors.lastname: Ghose
authors.forename: Kallol
authors.initials: K
authors.lastname: Bhattacharya
authors.forename: Kunal Kanti
authors.initials: KK
authors.lastname: Mazumdar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001151:Arsenic / Q000032:analysis / Q000652:urine*; D015415:Biomarkers / Q000652:urine*; D004032:Diet; D060766:Drinking Water / Q000032:analysis*; D005260:Female; D005506:Food Contamination / Q000032:analysis; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000652:urine*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D060766:Drinking Water; D014874:Water Pollutants, Chemical; D001151:Arsenic