title: [Progress in microbial production of succinic acid].
abstract: Succinic acid is one of the key intermediates in the tricarboxylic acid cycle (TCA)and has huge potentials in biopolymer, food, medicine applications. This article reviews recent research progress in the production of succinic acid by microbial fermentation, including discovery and screening of the succinic-acid-producing microbes, the progress of genetic engineering strategy and metabolic engineering technology for construction of succinic acid-producing strains, and fermentation process control and optimization. Finally, we discussed the limitation of current progress and proposed the future research needs for microbial production of succinic acid.
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, Jiangsu, China.
authors.forename: Rongming
authors.initials: R
authors.lastname: Liu
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, Jiangsu, China.
authors.forename: Liya
authors.initials: L
authors.lastname: Liang
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, Jiangsu, China.
authors.forename: Mingke
authors.initials: M
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816, Jiangsu, China.
authors.forename: Min
authors.initials: M
authors.lastname: Jiang
mesh_terms: D000188:Actinobacillus / Q000235:genetics / Q000378:metabolism*; D044064:Anaerobiospirillum / Q000235:genetics / Q000378:metabolism*; D005285:Fermentation; D007218:Industrial Microbiology / Q000379:methods* / Q000639:trends; D060847:Metabolic Engineering / Q000379:methods*; D019802:Succinic Acid / Q000378:metabolism*
chemical_list: D019802:Succinic Acid