title: Cystic rete testis with testicular dysplasia in a rabbit.
abstract: An 8-year-old intact rabbit was presented to a veterinary hospital with a complaint of enlarged left scrotum. Histological examination revealed a single large cyst adjacent to an efferent ductule-like tissue. The cyst wall was composed of monolayer cuboidal cells surrounded by dysplastic testicular tissue, and the seminiferous tubules were not developed at all. The epithelial cells of the cyst possessed the same properties as the epithelial cells of the rete testis that were positive for CD 10 and cytokeratin 18, negative for p63 and lacked desmin-positive muscular layer. The dysplastic testicular tissue was composed of two types of cells: small pleomorphic cells with a condensed nucleus (sex cord-like cells) and large round cells with cytoplasmic lipid droplets (Leydig cells). Both of these cells were positive for vimentin and melan A that are consistent with the staining pattern of Sertoli cells and Leydig cells. This is the first report to demonstrate cystic rete testis with testicular dysplasia in animals.
authors.affiliation: Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.
authors.forename: James K
authors.initials: JK
authors.lastname: Chambers
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Murata
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Watanabe
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ise
authors.forename: Yasutsugu
authors.initials: Y
authors.lastname: Miwa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
mesh_terms: D000818:Animals; D003560:Cysts / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D053538:Keratin-18 / Q000378:metabolism; D007985:Leydig Cells / Q000378:metabolism / Q000473:pathology; D058965:MART-1 Antigen / Q000378:metabolism; D008297:Male; D015260:Neprilysin / Q000378:metabolism; D011817:Rabbits; D012152:Rete Testis / Q000473:pathology*; D012708:Sertoli Cells / Q000378:metabolism / Q000473:pathology; D013737:Testis / Q000002:abnormalities* / Q000166:cytology; D014746:Vimentin / Q000378:metabolism
chemical_list: D053538:Keratin-18; D058965:MART-1 Antigen; D014746:Vimentin; D015260:Neprilysin