title: Everyday executive function in standard-risk acute lymphoblastic leukemia survivors.
abstract: We aimed to evaluate parent-rated executive function (EF) in pediatric standard risk acute lymphoblastic leukemia (SR-ALL) survivors compared to a healthy comparison (HC) group. We hypothesized that SR-ALL survivors would have greater reported executive dysfunction compared to HC, and that those younger at the time of treatment would demonstrate greater EF difficulties. A sample of 256 SR-ALL survivors evaluated an average nine years after treatment were compared to HC matched for gender, assessment age, and maternal education. Profile analysis was used to compare the groups across EF scales on the BRIEF. The prevalence of clinical elevations in the groups was compared via chi square, and odds ratios were calculated. Regression models were applied to examine the role of age at diagnosis and age at assessment in reported EF. Results indicated that SR-ALL survivors' mean scores of EF are similar to HC, except for flexibility and initiation. Survivors were rated as having clinical impairments with flexibility, initiation, working memory, and emotional control at rates two to three times that of HC. The risk of working memory and self-monitoring deficits was greater in survivors who were older when assessed. There was no relationship between age at diagnosis or treatment regimen on EF. These findings suggest sparing of extensive and severe EF deficits in SR-ALL survivors overall. However, a subset of survivors displays clinically significant executive dysfunction. There appears to be a heightened susceptibility to disrupted metacognitive functions as survivors age. This has implications for how we monitor neurocognitive development and functioning of SR-ALL survivors, and highlights opportunities for cognitive interventions.
authors.affiliation: a Children's National Medical Center & The George Washington University Medical Center , Washington , DC , USA.
authors.forename: Karin S
authors.initials: KS
authors.lastname: Walsh
authors.forename: Iris
authors.initials: I
authors.lastname: Paltin
authors.forename: Gerard A
authors.initials: GA
authors.lastname: Gioia
authors.forename: Peter
authors.initials: P
authors.lastname: Isquith
authors.forename: Nina S
authors.initials: NS
authors.lastname: Kadan-Lottick
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Neglia
authors.forename: Pim
authors.initials: P
authors.lastname: Brouwers
mesh_terms: D000367:Age Factors; D017668:Age of Onset; D016022:Case-Control Studies; D002648:Child; D003071:Cognition; D004644:Emotions; D056344:Executive Function; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008570:Memory, Short-Term; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010290:Parents / Q000523:psychology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000523:psychology*; D017741:Survivors / Q000523:psychology*; D013997:Time Factors
keywords: Central nervous system; Leukemia; Neurobehavioral manifestations; Neuropsychology; Survivors