title: Oxidative metabolism in cancer: A STAT affair?
abstract: STAT3 and STAT5 (STAT3/5) proteins are crucial mediators of cytokine- or growth factor-induced cell survival and proliferation. These transcription factors are frequently overactivated in a variety of solid tumors and hematopoietic neoplasms and are targets of various oncogenes with tyrosine kinase activity. STAT3/5 proteins regulate expression of genes involved in survival and proliferation in the nucleus and interact with signaling pathways in the cytoplasm. Evidences for a cross-talk between STAT3/5 and oxidative metabolism have recently emerged. This review summarizes the current knowledge on the cross-regulation between STAT3/5 and oxidative metabolism in normal and cancer cells.
authors.affiliation: CNRS UMR 7292; Université F. Rabelais; Faculté de Médecine; Tours, France.
authors.forename: Jérome
authors.initials: J
authors.lastname: Bourgeais
authors.affiliation: CNRS UMR 7292; Université F. Rabelais; Faculté de Médecine; Tours, France ; CHRU de Tours; Department of Immunology; Tours, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Gouilleux-Gruart
authors.affiliation: CNRS UMR 7292; Université F. Rabelais; Faculté de Médecine; Tours, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: Gouilleux
keywords: NOX; ROS; STAT3; STAT5; cancer; leukemia; mitochondria; oncogene; oxidative stress