title: Post-genomics nanotechnology is gaining momentum: nanoproteomics and applications in life sciences.
abstract: The post-genomics era has brought about new Omics biotechnologies, such as proteomics and metabolomics, as well as their novel applications to personal genomics and the quantified self. These advances are now also catalyzing other and newer post-genomics innovations, leading to convergences between Omics and nanotechnology. In this work, we systematically contextualize and exemplify an emerging strand of post-genomics life sciences, namely, nanoproteomics and its applications in health and integrative biological systems. Nanotechnology has been utilized as a complementary component to revolutionize proteomics through different kinds of nanotechnology applications, including nanoporous structures, functionalized nanoparticles, quantum dots, and polymeric nanostructures. Those applications, though still in their infancy, have led to several highly sensitive diagnostics and new methods of drug delivery and targeted therapy for clinical use. The present article differs from previous analyses of nanoproteomics in that it offers an in-depth and comparative evaluation of the attendant biotechnology portfolio and their applications as seen through the lens of post-genomics life sciences and biomedicine. These include: (1) immunosensors for inflammatory, pathogenic, and autoimmune markers for infectious and autoimmune diseases, (2) amplified immunoassays for detection of cancer biomarkers, and (3) methods for targeted therapy and automatically adjusted drug delivery such as in experimental stroke and brain injury studies. As nanoproteomics becomes available both to the clinician at the bedside and the citizens who are increasingly interested in access to novel post-genomics diagnostics through initiatives such as the quantified self, we anticipate further breakthroughs in personalized and targeted medicine.
authors.affiliation: 1 Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, McKnight Brain Institute, University of Florida , Gainesville, Florida.
authors.forename: Firas H
authors.initials: FH
authors.lastname: Kobeissy
authors.forename: Basri
authors.initials: B
authors.lastname: Gulbakan
authors.forename: Ali
authors.initials: A
authors.lastname: Alawieh
authors.forename: Pierre
authors.initials: P
authors.lastname: Karam
authors.forename: Zhiqun
authors.initials: Z
authors.lastname: Zhang
authors.forename: Joy D
authors.initials: JD
authors.lastname: Guingab-Cagmat
authors.forename: Stefania
authors.initials: S
authors.lastname: Mondello
authors.forename: Weihong
authors.initials: W
authors.lastname: Tan
authors.forename: John
authors.initials: J
authors.lastname: Anagli
authors.forename: Kevin
authors.initials: K
authors.lastname: Wang
mesh_terms: D001327:Autoimmune Diseases / Q000175:diagnosis / Q000628:therapy; D001690:Biological Science Disciplines; D015374:Biosensing Techniques; D003141:Communicable Diseases / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D007118:Immunoassay; D058990:Molecular Targeted Therapy; D049329:Nanostructures / Q000627:therapeutic use; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D057285:Precision Medicine / Q000295:instrumentation / Q000379:methods*; D040901:Proteomics / Q000295:instrumentation / Q000379:methods*