title: Sensitivity of fluid detection in patients with neovascular amd using spectral domain optical coherence tomography high-definition line scans.
abstract: OBJECTIVE
  To determine the sensitivity of the Cirrus high-definition (HD) 5-line raster scans for detecting retinal fluid in neovascular age-related macular degeneration when using the spectral domain optical coherence tomography macular cubes as a gold standard.
  
  
  METHODS
  Patients were retrospectively identified from their initial follow-up visit after being newly diagnosed with neovascular age-related macular degeneration in at least one eye. Patients were imaged with Cirrus spectral domain optical coherence tomography using the 512 × 128 macular cube scan and HD 5-line raster scan settings. Patients with other diseases that cause subretinal or intraretinal fluid, or who had an epiretinal membrane causing macular traction were excluded from the analysis. We recorded the presence or absence of subretinal or intraretinal fluid in the macular cube and on the HD 5-line raster scans.
  
  
  RESULTS
  Seventy-nine patients met the study requirements. Of the 63 patients who had fluid present on the macular cube, 1 did not seem to have fluid on the HD 5-line raster scans. Taking the macular cube as a gold standard, the sensitivity of the HD 5-line raster scans for detecting retinal fluid in this cohort was 98.4%.
  
  
  CONCLUSIONS
  The Cirrus HD 5-line raster scans have a high sensitivity for detecting fluid in the macular cube in patients with neovascular age-related macular degeneration.
authors.affiliation: *Department of Ophthalmology, California Pacific Medical Center, San Francisco, California; †West Coast Retina Medical Group, San Francisco, California; ‡Department of Ophthalmology, Stanford University School of Medicine, Stanford, California; and §Department of Vision Science, University of California, Berkeley, Berkeley, California.
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: De Niro
authors.forename: H Richard
authors.initials: HR
authors.lastname: McDonald
authors.forename: Robert N
authors.initials: RN
authors.lastname: Johnson
authors.forename: J Michael
authors.initials: JM
authors.lastname: Jumper
authors.forename: Arthur D
authors.initials: AD
authors.lastname: Fu
authors.forename: Emmett T
authors.initials: ET
authors.lastname: Cunningham
authors.forename: Brandon J
authors.initials: BJ
authors.lastname: Lujan
mesh_terms: D000368:Aged; D020256:Choroidal Neovascularization / Q000175:diagnosis*; D005122:Exudates and Transudates; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis*; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods