title: A clinical study of cortical auditory evoked potentials in cochlear implantees.
abstract: Normal maturation of central auditory pathways is a precondition for the optimal development of speech and language skills in children. The temporal cortex gets acoustically tagged due to auditory stimulation and important changes occur in the higher auditory centers due to hearing loss of any type and degree. Cochlear implantation increases auditory sensitivity by direct electrical activation of auditory nerve fibers, enabling phonemic awareness, discrimination and identification ultimately yielding speech understanding. Early implantation stimulates a brain that has not been re-organized and will therefore be more receptive to auditory input and greater auditory capacity. Cortical potentials have enabled us to objectively study this phenomenon. To assess the outcomes of Cochlear implants on the auditory cortex by analyzing cortical auditory evoked potentials (CAEPs) in the habilitation period. This prospective clinical study was performed in 30 pre-lingual candidates with varied etiology of deafness who underwent cochlear implantation at our institute over the last 1 year. The study group had two cohorts (group-1: 0-8 years and group-2: 8-15 years) which included candidates with normal inner ear and no syndromes or handicaps. All implantees in the study group underwent CAEP testing at 6 months and 1 year post-implantation and comparison of the CAEP wave parameters (P1 amplitude, P1 latency and P1 morphology) were done between the two cohorts. In children Implanted early (group-1) there was an early onset rapid increase in P1 amplitude along with a decrease in P1 latency during the follow-up period. Significant change in the CAEP wave morphology was also notable in group-1 unlike in group-2. Candidates who experienced less than 3 years of auditory deprivation before implantation showed P1 latencies, which fell into the range of normal children within 6 months of habilitation. Children with more than 6 years of auditory deprivation, however, generally did not develop normal P1 latencies or morphology even after 1 year of habilitation. The overall outcome with CAEP was much better in group-1 as compared to group-2 and the observations were is in comparison with the existing world literature. The advent of CAEP has objectively proved beyond doubt that there is a critical age for stimulating the auditory brain via cochlear implantation. There is considerable evidence for a developmental sensitive period, during which the auditory cortex is highly plastic. If sensory input is deprived to the auditory system during this sensitive period, then the central auditory system is susceptible to large scale reorganization. Restoring input to the auditory system by Cochlear Implant at an early age can provide the stimulation necessary to preserve the auditory pathways. However, if auditory input is not restored until after this developmental period, then the cross-modal reorganized pathways may exhibits abnormal functional characteristics as observed in recorded P1 amplitude, latencies and morphologies of CAEPs.
authors.affiliation: Department of Implant Otology, Madras ENT Research Foundation (MERF & MERF-ISH), No. 1, 1st Cross Street, Off 2nd Main Road, Raja Annamalaipuram, Chennai, 600028 TN India.
authors.forename: Mohammod Delwar
authors.initials: MD
authors.lastname: Hossain
authors.affiliation: Department of Implant Otology, Madras ENT Research Foundation (MERF & MERF-ISH), No. 1, 1st Cross Street, Off 2nd Main Road, Raja Annamalaipuram, Chennai, 600028 TN India.
authors.forename: S
authors.initials: S
authors.lastname: Raghunandhan
authors.affiliation: Department of Implant Otology, Madras ENT Research Foundation (MERF & MERF-ISH), No. 1, 1st Cross Street, Off 2nd Main Road, Raja Annamalaipuram, Chennai, 600028 TN India.
authors.forename: Mohan
authors.initials: M
authors.lastname: Kameswaran
authors.affiliation: Department of Implant Otology, Madras ENT Research Foundation (MERF & MERF-ISH), No. 1, 1st Cross Street, Off 2nd Main Road, Raja Annamalaipuram, Chennai, 600028 TN India.
authors.forename: R
authors.initials: R
authors.lastname: Ranjith
keywords: Central auditory processing; Cochlear implants; Cortical auditory evoked potentials (CAEPs)