title: Rapid heteronuclear single quantum correlation NMR spectra at natural abundance.
abstract: A novel NMR experiment, the so-called ASAP-HSQC, is introduced that allows the detection of heteronuclear one-bond correlations in less than 30 s on small molecules at natural abundance without compromises in sweep width, resolution or spectral quality. Equally, the experiment allows a significant increase in digital resolution or a moderate senstitivity enhancement in the same overall experiment time compared to a conventional HSQC. The gain is a consequence of keeping all unused proton magnetization along z during acquisition, so that the previously reported ASAP and ALSOFAST approaches can be transferred from HMQC to HSQC-type experiments. Next to basic and broadband pulse sequences, a characterization of the sequence with respect to minimum measurement time, sensitivity gain, and advantages in resolution compared to state-of-the-art experiments is given.
authors.affiliation: Institut für Organische Chemie and Institut für Biologische Grenzflächen, Karlsruher Institut für Technologie (KIT) , Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Schulze-Sünninghausen
authors.forename: Johanna
authors.initials: J
authors.lastname: Becker
authors.forename: Burkhard
authors.initials: B
authors.lastname: Luy
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D002236:Carbohydrate Conformation; D009682:Magnetic Resonance Spectroscopy / Q000379:methods* / Q000592:standards*; D008320:Maltose / Q000737:chemistry; D011789:Quantum Theory; D012015:Reference Standards
chemical_list: D001688:Biological Products; D008320:Maltose