title: The relationship between different glycemic statuses and colon polyps in a Taiwanese population.
abstract: BACKGROUND
  While diabetes is considered as a risk factor for colorectal cancer, there are few studies that address the association between glycemic statuses and different colon polyps, ranging from non-neoplastic polyps to advanced adenomatous polyps.
  
  
  METHODS
  A total of 6,348 participants, consisting of 3,777 men and 2,571 women, with a mean age of 50.5 years, were included for final analysis after excluding subjects with a past history of colorectal cancer, colon polyps/polypectomy, familial adenomatous polyposis, and colorectomy, or missing data. Diabetes and pre-diabetes were defined using the 2011 American Diabetes Association criteria. Subjects were classified into four groups: polyp-free, non-neoplastic polyps, non-advanced and advanced adenomatous polyps.
  
  
  RESULTS
  There were significant differences in the prevalence of diabetes and pre-diabetes among groups with different kinds of colon polyps. In addition, significant differences were also noted in age, total cholesterol, body mass index, triglyceride, high density lipoprotein-cholesterol, fasting plasma glucose, and the prevalence of male gender, hypertension, obesity, current smoking and alcohol drinking among groups. In the multinomial logistic regression analyses, diabetes was related to both non-advanced and advanced adenomatous polyps, while pre-diabetes was only related to non-advanced adenomatous polyps. In addition, age ≥65 years and male gender were associated with both non-advanced and advanced adenomatous polyps, while hypertension and current smoking were independently related to advanced and non-advanced adenomatous polyps, respectively.
  
  
  CONCLUSIONS
  Diabetes, but not pre-diabetes, was associated with a higher risk of advanced adenomatous polyps. In addition, both diabetes and pre-diabetes were important correlates of non-advanced adenomatous polyps.
authors.affiliation: Department of Family Medicine, National Cheng Kung University Hospital, 138, Sheng Li Road, Tainan, 70403, Taiwan, ROC.
authors.forename: Hsin-En
authors.initials: HE
authors.lastname: Huang
authors.forename: Yi-Ching
authors.initials: YC
authors.lastname: Yang
authors.forename: Jin-Shang
authors.initials: JS
authors.lastname: Wu
authors.forename: Ru-Hsueh
authors.initials: RH
authors.lastname: Wang
authors.forename: Feng-Hwa
authors.initials: FH
authors.lastname: Lu
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Chang
mesh_terms: D018256:Adenomatous Polyps / Q000097:blood / Q000453:epidemiology / Q000209:etiology; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003111:Colonic Polyps / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood / Q000150:complications / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology
chemical_list: D001786:Blood Glucose; D008055:Lipids