title: Cost-effectiveness of endovascular versus open repair of acute complicated type B aortic dissections.
abstract: OBJECTIVE
  This study weighed the cost and benefit of thoracic endovascular aortic repair (TEVAR) vs open repair (OR) in the treatment of an acute complicated type B aortic dissection by (TBAD) estimating the cost-effectiveness to determine an optimal treatment strategy based on the best currently available evidence.
  
  
  METHODS
  A cost-utility analysis from the perspective of the health system payer was performed using a decision analytic model. Within this model, the 1-year survival, quality-adjusted life-years (QALYs), and costs for a hypothetical cohort of patients with an acute complicated TBAD managed with TEVAR or OR were evaluated. Clinical effectiveness data, cost data, and transitional probabilities of different health states were derived from previously published high-quality studies or meta-analyses. Probabilistic sensitivity analyses were performed on uncertain model parameters.
  
  
  RESULTS
  The base-case analysis showed, in terms of QALYs, that OR appeared to be more expensive (incremental cost of €17,252.60) and less effective (-0.19 QALYs) compared with TEVAR; hence, in terms of the incremental cost-effectiveness ratio, OR was dominated by TEVAR. As a result, the incremental cost-effectiveness ratio (ie, the cost per life-year saved) was not calculated. The average cost-effectiveness ratio of TEVAR and OR per QALY gained was €56,316.79 and €108,421.91, respectively. In probabilistic sensitivity analyses, TEVAR was economically dominant in 100% of cases. The probability that TEVAR was economically attractive at a willingness-to-pay threshold of €50,000/QALY gained was 100%.
  
  
  CONCLUSIONS
  The present results suggest that TEVAR yielded more QALYs and was associated with lower 1-year costs compared with OR in patients with an acute complicated TBAD. As a result, from the cost-effectiveness point of view, TEVAR is the dominant therapy over OR for this disease under the predefined conditions.
authors.affiliation: Department of Vascular and Endovascular Surgery, University Hospital of Cologne, Cologne, Germany. Electronic address: thomas.luebke@uk-koeln.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Luebke
authors.affiliation: Department of Vascular and Endovascular Surgery, University Hospital of Cologne, Cologne, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Brunkwall
mesh_terms: D000208:Acute Disease; D000784:Aortic Dissection / Q000150:complications / Q000175:diagnosis / Q000191:economics* / Q000401:mortality / Q000601:surgery*; D001014:Aortic Aneurysm / Q000150:complications / Q000175:diagnosis / Q000191:economics* / Q000401:mortality / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000191:economics* / Q000401:mortality; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D057510:Endovascular Procedures / Q000009:adverse effects / Q000191:economics* / Q000401:mortality; D017721:Hospital Costs; D006801:Humans; D018803:Models, Economic; D011183:Postoperative Complications / Q000191:economics / Q000401:mortality / Q000628:therapy; D019057:Quality-Adjusted Life Years; D013997:Time Factors; D016896:Treatment Outcome