title: Membrane-anchored chemokine fusion proteins: A novel class of adjuvants for immunotherapy.
abstract: Adoptive or active cancer immunotherapy can fail owing to the inefficient recruitment of effector leukocytes to malignant lesions. The intratumoral injection of recombinant proteins comprising a chemokine-derived domain linked to the mucin stalk of chemokine (C-X3-C motif) ligand 1 (CX3CL1) and a glycosylphosphatidylinositol anchor can specifically enhance the recruitment of effector cell subsets to solid tumors.
authors.affiliation: AG Klinische Biochemie; Medizinische Klinik und Poliklinik IV; University of Munich; Munich, Germany.
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Nelson
authors.affiliation: The Scripps Research Institute; Institute for Immunology and Microbial Science; San Diego, CA USA.
authors.forename: Niklas
authors.initials: N
authors.lastname: Muenchmeier
keywords: GPI anchor; active immunotherapy; adoptive immunotherapy; cancer therapy; chemokine; endothelial anergy; leukocyte recruitment