title: STAT5 acetylation: Mechanisms and consequences for immunological control and leukemogenesis.
abstract: The cytokine-inducible transcription factors signal transducer and activator of transcription 5A and 5B (STAT5A and STAT5B) are important for the proper development of multicellular eukaryotes. Disturbed signaling cascades evoking uncontrolled expression of STAT5 target genes are associated with cancer and immunological failure. Here, we summarize how STAT5 acetylation is integrated into posttranslational modification networks within cells. Moreover, we focus on how inhibitors of deacetylases and tyrosine kinases can correct leukemogenic signaling nodes involving STAT5. Such small molecules can be exploited in the fight against neoplastic diseases and immunological disorders.
authors.affiliation: Center for Molecular Biomedicine (CMB); Institute of Biochemistry and Biophysics; University of Jena; Jena, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Kosan
authors.affiliation: Center for Molecular Biomedicine (CMB); Institute of Biochemistry and Biophysics; University of Jena; Jena, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Ginter
authors.affiliation: Center for Molecular Biomedicine (CMB); Institute of Biochemistry and Biophysics; University of Jena; Jena, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Heinzel
authors.affiliation: Center for Molecular Biomedicine (CMB); Institute of Biochemistry and Biophysics; University of Jena; Jena, Germany ; Institute of Toxicology; Medical Center of the University Mainz; Mainz, Germany.
authors.forename: Oliver H
authors.initials: OH
authors.lastname: Krämer
keywords: HAT; HDAC; HDACi; SIAH; STAT; STAT5; UBCH8; acetylation; cancer; leukemia