title: Synthesis and study the controlled release of etronidazole from the new PEG/NaY and PEG/MCM-41 nanocomposites.
abstract: Recently, hybrid materials using poly ethylene glycol and porous nanocrystals have been developed for drug release. In this study, a series of poly ethylene glycol (PEG)/NaY zeolite and PEG/MCM-41 nanocomposites get synthesized. These materials are characterized using FT-IR spectroscopy, XRD, TGA and SEM. After loading the metronidazole onto these nanocomposites, the release of Metronidazole was studied in two kinds of release fluids simulating body fluid KH2PO4-Na2HPO4 buffer (pH = 7.4) and gastric fluid (HCl aqueous solution, pH = 1.5) while controlling the time, pH values, and temperature using UV-vis. Results showed that these nanocomposites have further release related to NaY, MCM-41 and the order of release in two pH solutions was PEG/NaY > PEG/MCM-41 > NaY > MCM-41. The behavior of drug release in these nanocomposites is probably due to hydrogen bonding interactions between drug and the hydroxyl group on the composite framework.
authors.affiliation: Department of Chemistry, Faculty of Science, Arak University, Arak 38156-8-8349, Iran. m-zendehdel@araku.ac.ir.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Zendehdel
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cruciani
authors.forename: Forozan Sahra
authors.initials: FS
authors.lastname: Kar
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Barati