title: Secrets of the secretome in Staphylococcus aureus.
abstract: Secreted proteins constitute a reservoir of virulence factors. Here, an in silico analysis of the secretome of 15 S. aureus reference strains is presented revealing that about 30% of the encoded proteome of this bacterium could be secreted. In total 1354 proteins were predicted to be localized outside the cytoplasm representing the pan-secretome of S. aureus. 41% of these proteins have been identified to be expressed using different approaches. The function of at least 50% of the secreted proteins encoded by S. aureus is not yet clear and a possible role in virulence has to be elucidated.
authors.affiliation: Institut für Mikrobiologie, Ernst-Moritz-Arndt-Universität, 17487 Greifswald, Germany.
authors.forename: Harald
authors.initials: H
authors.lastname: Kusch
authors.affiliation: Institut für Mikrobiologie, Ernst-Moritz-Arndt-Universität, 17487 Greifswald, Germany; Institut für Mikrobiologie, Technische Universität Braunschweig, 38023 Braunschweig, Germany; Helmholtzzentrum für Infektionsforschung, 38124 Braunschweig, Germany. Electronic address: Susanne.Engelmann@helmholtz-hzi.de.
authors.forename: Susanne
authors.initials: S
authors.lastname: Engelmann
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D006801:Humans; D020543:Proteome / Q000032:analysis*; D013211:Staphylococcus aureus / Q000737:chemistry*; D037521:Virulence Factors / Q000032:analysis*
chemical_list: D001426:Bacterial Proteins; D020543:Proteome; D037521:Virulence Factors
keywords: Hypothetical proteins; Protein secretion; Proteomics; Secretome; Staphylococcus aureus