title: Efficacy of doramectin in Trixacarus caviae infestation in guinea pigs (Cavia porcellus).
abstract: The present study was intended to evaluate the efficacy of doramectin against seven naturally Trixacarus caviae infested male guinea pigs. Multiple skin scrapings of all the seven guinea pigs were found microscopically positive for T. caviae mites. Clinically these animals revealed, more or less denuded, very red often thickened, and crustated cutaneous lesions restricted at the sacral region and back. Doramectin 1 % (w/v) was administered intramuscularly at a dose rate of 400 μg/kg once weekly, which resulted in profound improvements in clinical conditions within 14 days after the first doramectin application. It took almost 28 days for the cutaneous lesions to disappear and to witness partial hair coat regrowth. Two moderately infested guinea pigs required only single injection of doramectin to achieve complete parasitological cure, while remaining five (one moderately infested and four severely infested) guinea pigs required two injections of doramectin to achieve complete parasitological cure. No adverse effects were revealed by any of the doramectin treated guinea pigs during the study period. Thus, it can be concluded from the present study that guinea pigs naturally infested by T. caviae mites can be cured safely using two doses of doramectin once in a week.
authors.affiliation: Laboratory Animals Resource Section, Sri Ram Murti Smarak Institute of Medical Sciences, Bhojipura, Bareilly, 243 202 UP India ; Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281001 UP India.
authors.forename: Shanker K
authors.initials: SK
authors.lastname: Singh
authors.affiliation: Division of Medicine, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243 122 UP India.
authors.forename: Umesh
authors.initials: U
authors.lastname: Dimri
authors.affiliation: Department of Pharmacology, Sri Ram Murti Smarak Institute of Medical Sciences, Bhojipura, Bareilly, 243 202 UP India.
authors.forename: Quazi Shahir
authors.initials: QS
authors.lastname: Ahmed
authors.affiliation: Department of Pharmacology, Sri Ram Murti Smarak Institute of Medical Sciences, Bhojipura, Bareilly, 243 202 UP India.
authors.forename: Kauser
authors.initials: K
authors.lastname: Sayedda
authors.affiliation: Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, DUVASU, Mathura, 281001 UP India.
authors.forename: Krishna Veer
authors.initials: KV
authors.lastname: Singh
keywords: Doramectin; Guinea pigs; Mange; Trixacaruscaviae