title: An enzymatic chromatin switch that directs formation of active brown fat.
abstract: How is the recruitment of brown adipocytes regulated? Ohno et al. (2013) show that the euchromatic histone-lysine N-metyltransferase 1 (EHMT1) is essential for the specification of the brown adipocyte fate, a finding with important implications for the pathophysiology of obesity and obesity-related maladies.
authors.affiliation: Department of Medical and Clinical Genetics, Institute of Biomedicine, University of Gothenburg, Medicinaregatan 9A, P.O. Box 440, 405 30 Göteborg, Sweden. Electronic address: sven.enerback@medgen.gu.se.
authors.forename: Sven
authors.initials: S
authors.lastname: Enerbäck
mesh_terms: D002001:Adipose Tissue, Brown / Q000166:cytology* / Q000201:enzymology*; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D006801:Humans; D022722:Thermogenesis / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors; D011495:Histone-Lysine N-Methyltransferase