title: Leveraging the micellar effect: gold-catalyzed dehydrative cyclizations in water at room temperature.
abstract: The first examples of gold-catalyzed cyclizations of diols and triols to the corresponding hetero- or spirocycles in an aqueous medium are presented. These reactions take place within nanomicelles, where the hydrophobic effect is operating, thereby driving the dehydrations, notwithstanding the surrounding water. By the addition of simple salts such as sodium chloride, reaction times and catalyst loadings can be significantly decreased.
authors.affiliation: Organic Chemistry, Dortmund University of Technology , Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany.
authors.forename: Stefan R K
authors.initials: SR
authors.lastname: Minkler
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Isley
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Lippincott
authors.forename: Norbert
authors.initials: N
authors.lastname: Krause
authors.forename: Bruce H
authors.initials: BH
authors.lastname: Lipshutz
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D008823:Micelles; D015394:Molecular Structure; D012965:Sodium Chloride / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D000438:Alcohols; D008823:Micelles; D014867:Water; D012965:Sodium Chloride; D006046:Gold