title: Interactions between the dietary polyunsaturated fatty acid ratio and genetic factors determine susceptibility to pediatric Crohn's disease.
abstract: Increased dietary ratios of ω6/ω3 polyunsaturated fatty acids have been implicated in the pathogenesis of Crohn's disease (CD), but epidemiologic data are limited. We investigated whether variants of genes that control polyunsaturated fatty acid metabolism (CYP4F3, FADS1, and FADS2), along with the dietary ratio of ω6/ω3, confers susceptibility to CD. Based on data from 182 children newly diagnosed with CD and 250 controls, we found that children who consumed a higher dietary ratio of ω6/ω3 were susceptible for CD if they were also carriers of specific variants of CYP4F3 and FADS2 genes. Our findings implicate diet-gene interactions in the pathogenesis of CD.
authors.affiliation: Public Health Agency of Canada, Montreal, Canada.
authors.forename: Irina
authors.initials: I
authors.lastname: Costea
authors.affiliation: Division of Gastroenterology, Children's Hospital of Eastern Ontario, Ottawa, Canada.
authors.forename: David R
authors.initials: DR
authors.lastname: Mack
authors.affiliation: Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
authors.forename: Rozenn N
authors.initials: RN
authors.lastname: Lemaitre
authors.affiliation: Division of Gastroenterology, Hepatology and Nutrition, British Columbia's Children's Hospital, Vancouver, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Israel
authors.affiliation: Research Institute, McGill University, Montreal, Quebec, Canada.
authors.forename: Valerie
authors.initials: V
authors.lastname: Marcil
authors.affiliation: Department of Microbiology and Immunology, University of Montreal, Quebec, Canada; Research Centre, Le Centre Hospitalier Universitaire-Ste-Justine, Montreal, Canada.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahmad
authors.affiliation: Research Centre, Le Centre Hospitalier Universitaire-Ste-Justine, Montreal, Canada; Department of Pediatrics, University of Montreal, Quebec, Canada. Electronic address: devendra.amre@gmail.com.
authors.forename: Devendra K
authors.initials: DK
authors.lastname: Amre
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D003424:Crohn Disease / Q000201:enzymology / Q000209:etiology* / Q000235:genetics; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D000072470:Cytochrome P450 Family 4; D000090943:Delta-5 Fatty Acid Desaturase; D044943:Fatty Acid Desaturases / Q000235:genetics* / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000009:adverse effects* / Q000378:metabolism; D043371:Fatty Acids, Omega-6 / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D000090943:Delta-5 Fatty Acid Desaturase; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; C465349:CYP4F3 protein, human; D044943:Fatty Acid Desaturases; C000716847:FADS1 protein, human; C533241:FADS2 protein, human
keywords: DNA; Fat Content; Food; Inflammatory Bowel Disease