title: A lysosome-specific two-photon phosphorescent binuclear cyclometalated platinum(II) probe for in vivo imaging of live neurons.
abstract: Real-time tracking of fast axonal transport of acidic vesicles in live adult mouse dorsal root ganglion (DRG) and cortical neurons in brain slices was visualized by the use of binuclear cycloplatinated complexes, {[Pt(L1)]2(μ-dppm)}(2+) (1) and {[Pt(L2)]2(μ-dppm)}(2+) (2), as lysosome-specific two-photon imaging probes.
authors.affiliation: Department of Biology & Chemistry, City University of Hong Kong, Tat Chee Ave., Kowloon, Hong Kong. eddiema@cityu.edu.hk bhmhwlam@cityu.edu.hk.
authors.forename: Yu-Man
authors.initials: YM
authors.lastname: Ho
authors.forename: Ngan-Pan Bennett
authors.initials: NP
authors.lastname: Au
authors.forename: Ka-Leung
authors.initials: KL
authors.lastname: Wong
authors.forename: Chris Tsz-Leung
authors.initials: CT
authors.lastname: Chan
authors.forename: Wai-Ming
authors.initials: WM
authors.lastname: Kwok
authors.forename: Ga-Lai
authors.initials: GL
authors.lastname: Law
authors.forename: Kwong-Kit
authors.initials: KK
authors.lastname: Tang
authors.forename: Wai-Yeung
authors.initials: WY
authors.lastname: Wong
authors.forename: Chi-Him Eddie
authors.initials: CH
authors.lastname: Ma
authors.forename: Michael Hon-Wah
authors.initials: MH
authors.lastname: Lam
mesh_terms: D000818:Animals; D005456:Fluorescent Dyes; D005727:Ganglia, Spinal / Q000166:cytology* / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D061848:Optical Imaging / Q000379:methods*; D009944:Organoplatinum Compounds / Q000737:chemistry*; D017785:Photons
chemical_list: D005456:Fluorescent Dyes; D009944:Organoplatinum Compounds