title: Synthesis of 2-phenylazonaphtho[1,8-ef][1,4]diazepines and 9-(3-arylhydrazono)pyrrolo[1,2-a]perimidines as antitumor agents.
abstract: Two series of naphtho[1,8-ef][1,4]diazepines and pyrrolo[1,2-a]perimidines were prepared starting from 1,8-diaminonaphthalene and hydrazonoyl chlorides. The structures of the products were determined on the basis of their spectral data and elemental analyses. The mechanism of formation of such products was also discussed. The prepared compounds were screened for their antitumor activity against three cell lines, namely, MCF-7, TK-10 and UACC-62, and some derivatives showed promising activity.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt. thoraya-f@hotmail.com.
authors.forename: Thoraya A
authors.initials: TA
authors.lastname: Farghaly
authors.affiliation: Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt. eman_m69@yahoo.com.
authors.forename: Eman M H
authors.initials: EM
authors.lastname: Abbas
authors.affiliation: Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt. dr_dawood@yahoo.com.
authors.forename: Kamal M
authors.initials: KM
authors.lastname: Dawood
authors.affiliation: Department of Chemistry, Faculty of Science, University of Cairo, Giza 12613, Egypt. telnaggar@yahoo.com.
authors.forename: Tarek B A
authors.initials: TB
authors.lastname: El-Naggar
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001381:Azepines; D011799:Quinazolines; C022049:perimidine