title: Sleep-related eating disorder: a descriptive study in Chilean patients.
abstract: OBJECTIVE
  We aimed to describe a group of adults diagnosed with sleep-related eating disorder (SRED) at the Sleep Medicine Center of the Pontificia Universidad Catolica de Chile.
  
  
  METHODS
  We performed a descriptive study of 34 consecutive patients who met the criteria of the International Classification of Sleep Disorders for SRED evaluated during a 3-year period who did not have an eating disorder according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. All patients had a structured clinical interview performed by a sleep specialist and completed the Beck Depression Inventory (BDI). Polysomnography (PSG) was performed when clinically indicated for ruling out other sleep-related disorders (18 patients; 52.9%). Patients' demographic and clinical data, comorbidities, and treatment response also were analyzed.
  
  
  RESULTS
  Most patients were women (n=23; 67.6%). The average age at the time of diagnosis was 39±13.8 (17-67 years) and the latency since symptom onset was 8.3±8.8 years. Most patients had several episodes per night (average, 2.6±1.6; 1-8) and all except one patient had partial or total amnesia of these events (n=33; 97%). Comorbidities were frequent and included insomnia (n=20; 58.8%), restless legs syndrome (RLS) (n=16; 47%), sleep-disordered breathing (SDB) (n=9; 26%), psychiatric disorders (n=13; 38.2%), and overweight or obesity (n=14; 41.1%). Most patients were hypnotic users (n=21; 61.7%) and reported weight-centered anxiety (n=23; 67.6%). Twenty patients (58.8%) were treated with topiramate, 17 of whom had adequate symptomatic responses.
  
  
  CONCLUSIONS
  Our SRED patients showed female preponderance, amnesia during the episodes, association with other sleep disorders, use of hypnotics, weight-centered anxiety, and positive response to topiramate. The presence of anxiety focused on weight in most patients may be an important element in the emergence of this behavior during sleep.
authors.affiliation: Centro Médico del Sueño, Division of Neurosciences, Pontificia Universidad Catolica de Chile, Chile. Electronic address: jsantin@med.puc.cl.
authors.forename: Julia
authors.initials: J
authors.lastname: Santin
authors.affiliation: Centro Médico del Sueño, Division of Neurosciences, Pontificia Universidad Catolica de Chile, Chile.
authors.forename: Victoria
authors.initials: V
authors.lastname: Mery
authors.affiliation: Centro Médico del Sueño, Division of Neurosciences, Pontificia Universidad Catolica de Chile, Chile.
authors.forename: María José
authors.initials: MJ
authors.lastname: Elso
authors.affiliation: Centro Médico del Sueño, Division of Neurosciences, Pontificia Universidad Catolica de Chile, Chile.
authors.forename: Eva
authors.initials: E
authors.lastname: Retamal
authors.affiliation: Centro Médico del Sueño, Division of Neurosciences, Pontificia Universidad Catolica de Chile, Chile.
authors.forename: Catalina
authors.initials: C
authors.lastname: Torres
authors.affiliation: Centro Médico del Sueño, Division of Neurosciences, Pontificia Universidad Catolica de Chile, Chile.
authors.forename: José
authors.initials: J
authors.lastname: Ivelic
authors.affiliation: Centro Médico del Sueño, Division of Neurosciences, Pontificia Universidad Catolica de Chile, Chile.
authors.forename: Jaime
authors.initials: J
authors.lastname: Godoy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002677:Chile / Q000453:epidemiology; D015897:Comorbidity; D001068:Feeding and Eating Disorders / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use; D017286:Polysomnography; D012148:Restless Legs Syndrome / Q000453:epidemiology; D012737:Sex Factors; D007319:Sleep Initiation and Maintenance Disorders / Q000453:epidemiology; D012893:Sleep Wake Disorders / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology; D000077236:Topiramate; D055815:Young Adult
chemical_list: D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose
keywords: Hypnotic; Parasomnia; Sleep disorders; Sleep-related eating; Topiramate; Zolpidem