title: Expression and function of a novel isoform of Sox5 in malignant B cells.
abstract: Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3(-/-) B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3(-/-) B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and β-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells.
authors.affiliation: Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United States; Graduate Program in Molecular Biosciences, Rutgers University, Piscataway, NJ 08854, United States.
authors.forename: Shanique K E
authors.initials: SK
authors.lastname: Edwards
authors.affiliation: Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United States.
authors.forename: Anand
authors.initials: A
authors.lastname: Desai
authors.affiliation: Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United States.
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United States.
authors.forename: Carissa R
authors.initials: CR
authors.lastname: Moore
authors.affiliation: Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ 08854, United States; Rutgers Cancer Institute of New Jersey, United States. Electronic address: xiep@rci.rutgers.edu.
authors.forename: Ping
authors.initials: P
authors.lastname: Xie
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D002453:Cell Cycle / Q000235:genetics; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism / Q000648:ultrastructure; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D055755:SOXD Transcription Factors / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction; D048008:TNF Receptor-Associated Factor 3 / Q000172:deficiency / Q000235:genetics*; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
chemical_list: D000906:Antibodies; C495270:CTNNB1 protein, human; D008070:Lipopolysaccharides; D018809:Proliferating Cell Nuclear Antigen; D020033:Protein Isoforms; D055755:SOXD Transcription Factors; C089186:Sox5 protein, mouse; D048008:TNF Receptor-Associated Factor 3; D051176:beta Catenin; C413374:p27 antigen
keywords: B lymphoma; Multiple myeloma; Sox5; TRAF3; p27; β-Catenin