title: [Advances in studies on 3-hydroxy-3-metllylglutaryl coenzyme A reductase in terpenoids biosynthesis of medicinal plants].
abstract: There exists many kinds and a huge number of terpenoid in medicinal plants, which show a wide range of pharmacological activities. 3-Hydroxy-3-metllylglutaryl coenzyme A reductase(HMGR) is a key rate-limiting enzyme in terpenoid biosynthetic pathway . HMGR plays an important role in the regulation of secondary metabolism of the terpenoid. The paper summarized the biological function and the catalytic mechanism of HMGR, the cloning and the structure of the gene as well as its research progress in some medicinal plants.
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China. lyjlife@sina.com
authors.forename: Yu-Jia
authors.initials: YJ
authors.lastname: Liu
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Xia-Nan
authors.initials: XN
authors.lastname: Zhang
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Qi-Qing
authors.initials: QQ
authors.lastname: Cheng
authors.affiliation: National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Lu-Qi
authors.initials: LQ
authors.lastname: Huang
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
mesh_terms: D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D010946:Plants, Medicinal / Q000201:enzymology*; D013729:Terpenes / Q000378:metabolism*
chemical_list: D013729:Terpenes; D006903:Hydroxymethylglutaryl CoA Reductases