title: Is uremic cardiomyopathy a direct consequence of chronic kidney disease?
abstract: Heart failure is a major cause of morbidity and mortality in chronic kidney disease (CKD). Rather than merely secondary to traditional vascular factors, CKD is also an independent risk factor for heart failure, termed uremic cardiomyopathy (UCM). Echocardiography commonly reveals structural left ventricular hypertrophy in CKD, without clarifying whether it is adaptive or maladaptive. Corresponding functional assessments have been mostly conducted at rest. To unravel the extents and mechanisms UCM, a next step involves the adoption of direct measurements of CKD-induced cardiac pumping incapacity at peak exercise. This could potentially lead to future novel interventions to ameliorate or reverse UCM.
authors.affiliation: Leeds Institute of Biomedical and Clinical Sciences, University of Leeds and Leeds General Infirmary, Leeds, UK.
authors.forename: Shanmugakumar
authors.initials: S
authors.lastname: Chinnappa
authors.forename: Sandeep S
authors.initials: SS
authors.lastname: Hothi
authors.forename: Lip-Bun
authors.initials: LB
authors.lastname: Tan
mesh_terms: D009202:Cardiomyopathies / Q000209:etiology* / Q000503:physiopathology; D004452:Echocardiography; D005080:Exercise Test / Q000379:methods; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000503:physiopathology; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors; D014511:Uremia / Q000209:etiology*