title: Plasminogen activator inhibitor-1 -675 4G/5G polymorphism and polycystic ovary syndrome risk: a meta analysis.
abstract: OBJECTIVE
  Several studies have reported that excessive amounts of plasminogen activator inhibitor-1(PAI-1) might increase the incidence of polycystic ovary syndrome(PCOS), but so far the published results were inconsistent. The aim of this study was to further investigate the association between PAI-1 gene polymorphism and the susceptibility to PCOS by performing a meta-analysis.
  
  
  METHODS
  A comprehensive literature search for relevant studies was conducted on google scholar, PubMed, the Chinese National Knowledge Infrastructure (CNKI) and the Chinese Biomedical Literature Database (CBM). This meta-analysis was performed using the STATA 11.0 software and the pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.
  
  
  RESULTS
  Ten case-control studies were included in this meta-analysis with a total of 2,079 cases and 1,556 controls. The results showed that PAI-1 -675 4G/5G polymorphism may increase the risk of PCOS, especially among Asian populations. However, there was no statistically significant association between the polymorphism and PCOS risk in Caucasians.
  
  
  CONCLUSIONS
  Our meta-analysis suggests that PAI-1 -675 4G/5G polymorphism may contribute to increasing susceptibility to PCOS in Asians. Detection of the PAI-1 gene polymorphism might be a promising biomarker for the susceptibility of PCOS.
authors.affiliation: Department of Occupational and Environmental, School of Public Health, Anhui Medical University, Meishan Road, Hefei, Anhui, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Mei-Guo
authors.initials: MG
authors.lastname: Sun
authors.forename: Rong
authors.initials: R
authors.lastname: Jiang
authors.forename: Rui
authors.initials: R
authors.lastname: Ding
authors.forename: Zhen
authors.initials: Z
authors.lastname: Che
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Chen
authors.forename: Ci-Jiang
authors.initials: CJ
authors.lastname: Yao
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Zhu
authors.forename: Ji-Yu
authors.initials: JY
authors.lastname: Cao
mesh_terms: D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D017395:Plasminogen Activator Inhibitor 1