title: Anti-pathogenic Potential of Coral Associated Bacteria Isolated from Gulf of Mannar Against Pseudomonas aeruginosa.
abstract: Infections of Pseudomonas aeruginosa are of great concern because of its increasing resistance towards conventional antibiotics. Quorum sensing system of P. aeruginosa acts as a global regulator of almost all the virulence factors and majorly its biofilm formation. In the present study, quenching of QS system of P. aeruginosa has been explained with bioactives from bacteria associated with the coral Acropora digitifera. Isolated bioactives inhibited the expression of various virulence traits of P. aeruginosa like biofilm formation, and the production of extracellular enzymes like protease and elastase. This study also emphasises the potential of coral associated bacteria in producing bioactive agents with anti-pathogenic properties.
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi, 630003 TN India.
authors.forename: Dhamodharan
authors.initials: D
authors.lastname: Bakkiyaraj
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi, 630003 TN India.
authors.forename: Chandran
authors.initials: C
authors.lastname: Sivasankar
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi, 630003 TN India.
authors.forename: Shunmugiah Karutha
authors.initials: SK
authors.lastname: Pandian
keywords: Anti-QS; Biofilm; Coral associated bacteria; Pseudomonas aeruginosa; Quorum sensing; Quorum sensing inhibitor