title: Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer.
abstract: The purpose of the study was to explore the significance of FGFR4 protein expression in colorectal cancer. Immunohistochemistry showed 46.8% (148/316) tumors positive for FGFR4 and 7.3% (23/316) for adjacent normal specimens. FGFR4 positivity was correlated with shortened disease free survival (DFS) and overall survival (OS). Multivariate analysis revealed that FGFR4 was an independent prognostic factor. FGFR4 silencing markedly reduced the migration and invasion capacity of colorectal cancer cell lines. These results suggest FGFR4 is a potential prognostic and therapeutic marker for colorectal cancer.
authors.affiliation: Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, Shandong Province , China .
authors.forename: Chen-Sheng
authors.initials: CS
authors.lastname: Li
authors.forename: Shu-Xiang
authors.initials: SX
authors.lastname: Zhang
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Liu
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Shi
authors.forename: Le-Ping
authors.initials: LP
authors.lastname: Li
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Guo
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Zhang
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D045744:Cell Line, Tumor; D002465:Cell Movement; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality; D005260:Female; D015870:Gene Expression; D055785:Gene Knockdown Techniques; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C496371:FGFR4 protein, human; D051499:Receptor, Fibroblast Growth Factor, Type 4