title: Pathologically confirmed malignant syphilis using immunohistochemical staining: report of 3 cases and review of the literature.
abstract: Malignant syphilis is a rare ulcerative variety. In the classical description of the disease, the absence of spirochetes in tissue samples was considered as a diagnostic criterion. We report 3 cases of malignant syphilis; in all of them, spirochetes were identified in cutaneous biopsy samples using immunohistochemical staining.
authors.affiliation: From the Departments of *Dermatology, †Internal Medicine, and ‡Pathology, Hospital Universitario La Paz, Madrid, Spain.
authors.forename: Paola Maldonado
authors.initials: PM
authors.lastname: Cid
authors.forename: Elena Sendagorta
authors.initials: ES
authors.lastname: Cudós
authors.forename: Francisco X
authors.initials: FX
authors.lastname: Zamora Vargas
authors.forename: María José Beato
authors.initials: MJ
authors.lastname: Merino
authors.forename: Pedro Herranz
authors.initials: PH
authors.lastname: Pinto
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D018791:CD4 Lymphocyte Count; D006801:Humans; D007150:Immunohistochemistry; D007273:Injections, Intramuscular; D008297:Male; D010401:Penicillin G Benzathine / Q000008:administration & dosage*; D012720:Severity of Illness Index; D013591:Syphilis, Cutaneous / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D016896:Treatment Outcome; D014210:Treponema pallidum / Q000302:isolation & purification*; D019562:Viral Load
chemical_list: D000900:Anti-Bacterial Agents; D010401:Penicillin G Benzathine