title: A community cluster of influenza A(H1N1)pdm09 virus exhibiting cross-resistance to oseltamivir and peramivir in Japan, November to December 2013.
abstract: Six influenza A(H1N1)pdm09 viruses were detected in Sapporo, Japan, between November and December 2013. All six viruses possessed an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir. No epidemiological link among the six cases could be identified; none of them had received neuraminidase inhibitors before specimen collection. The haemagglutinin and neuraminidase genes of the six viruses were closely related to one another, suggesting clonal spread of a single resistant virus.
authors.affiliation: Influenza Virus Research Center, National Institute of Infectious Diseases, Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Takashita
authors.forename: M
authors.initials: M
authors.lastname: Ejima
authors.forename: R
authors.initials: R
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: A
authors.initials: A
authors.lastname: Ohnishi
authors.forename: H
authors.initials: H
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Odagiri
authors.forename: M
authors.initials: M
authors.lastname: Tashiro
mesh_terms: D000146:Acids, Carbocyclic; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003517:Cyclopentanes / Q000494:pharmacology* / Q000627:therapeutic use; D004279:DNA, Viral; D024882:Drug Resistance, Viral; D005260:Female; D006146:Guanidines / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics / Q000627:therapeutic use; D053139:Oseltamivir / Q000494:pharmacology* / Q000627:therapeutic use; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome
chemical_list: D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D004279:DNA, Viral; D006146:Guanidines; D053139:Oseltamivir; D009439:Neuraminidase; C414210:peramivir