title: JAK-STAT and intestinal mucosal immunology.
abstract: The intestinal mucosal immune system is challenged with bacteria, viruses, and parasites, in addition to food and environmental antigens, that require dynamic immune responsiveness for homeostasis. One central signaling pathway is JAK-STAT, which regulates the adaptive and innate immune arms of mucosal immunity as well as epithelial repair and regeneration. Adaptive immunity includes lymphocyte mediated secretion of specific antibodies, while innate immune respones include secretion of non-antigen specific compounds. This review examines effects of specialized nutrition support on JAK-STAT in innate immune function and in lymphocyte modulation and epithelial antibody transport in gut-associated lymphoid tissue.
authors.affiliation: Department of Surgery; University of Wisconsin-Madison School of Medicine and Public Health; Madison, WI USA.
authors.forename: Aaron F
authors.initials: AF
authors.lastname: Heneghan
authors.affiliation: Department of Surgery; University of Wisconsin-Madison School of Medicine and Public Health; Madison, WI USA.
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Pierre
authors.affiliation: Department of Surgery; University of Wisconsin-Madison School of Medicine and Public Health; Madison, WI USA ; Veteran Administration Surgical Service; William S. Middleton Memorial Veterans Hospital; Madison, WI USA.
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Kudsk
keywords: JAK-STAT; Paneth cells; Peyer patches; STAT4; STAT6; goblet cells; mucosal immunity; pIgR; sIgA