title: Hematological Parameters and RBC TBARS Level of Q 10 Supplemented Tribal Sickle Cell Patients: A Hospital Based Study.
abstract: The study has been undertaken as number of sickle cell patients in Chhattisgarh tribal population is 23.7 %. The Co enzyme Q10 is a strong antioxidant and energy producing compound. The patients were divided into three groups group A homozygous (SS), group B heterozygous (AS) and group C controls for TBARS study. The age group is 10-55 years and 200 mg of CoQ10 was given to A and B groups. The hematological parameters, C reactive protein as well as RBC TBARS level were performed by usual and standard techniques. The results were obtained as 25.37 % increased RBC level in group A and 23.24 % in group B. The increased hemoglobin level was observed as 16.73 % in group A and 10.7 % in group B. In case of WBC it was observed increased 24.38 % in group A and 12.0 % in group B. C-reactive protein was observed 7.8 times decreased in group A and 1.54 times in group B. The RBC TBARS level was also found decreased 48 % in group A and 51 % in group B as compared to group C. During the supplementation of coenzyme Q10 the pain caused by vaso-occlusive events has reduced. This significant increase in hematological parameters as well as decreased C-reactive protein and TBARS level suggest that the Q10 should be included in the diet of sickle cell patients.
authors.affiliation: Department of Biochemistry, Government Medical College, Jagdalpur, CG 494 001 India.
authors.forename: A S
authors.initials: AS
authors.lastname: Thakur
authors.affiliation: Institute of Biochemistry, University of Ancona, Via Rameri, Ancona, Italy.
authors.forename: G P
authors.initials: GP
authors.lastname: Littaru
authors.affiliation: Production and Research Pharma Nord, Sadelmagervej 30-32, 7100 Vejle, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Moesgaard
authors.affiliation: Research Department, Sadelmagervej 30-32, 7100 Vejle, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Dan Sindberg
authors.affiliation: Department of Medicine, Chhattisgarh Institute of Medical Sciences, Bilaspur, CG India.
authors.forename: Y
authors.initials: Y
authors.lastname: Khan
authors.affiliation: Department of Community Medicine, RIMS, Saifay, Etawah, U.P. India.
authors.forename: C M
authors.initials: CM
authors.lastname: Singh
keywords: CoQ10; Coenzyme Q10; TBARS-Thiobarbituric acid reactive species