title: Molecular dynamics simulation of interlayer water embedded in phospholipid bilayer.
abstract: 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid bilayer with a thin layer of water molecules inserted in the hydrophobic region was simulated at 300K to observe the pore structure formation during escape of the water molecules from the hydrophobic region. The transformation of the water slab into a cylindrical droplet in the hydrophobic region, which locally deformed the lipid monolayer, was prerequisite to the pore formation. If the thickness of the interlayer water was increased beyond a critical value, the local deformation was suppressed as such deformation would rupture the lipid bilayer. Hence, it was demonstrated that the pore structure formation or local permeability of the lipid membrane is closely related to the rigidity of the lipid membrane.
authors.affiliation: Division of Materials Science and Engineering, Hanyang University, Seoul 133-791, Republic of Korea.
authors.forename: Won Bae
authors.initials: WB
authors.lastname: Han
authors.affiliation: Samsung Electronics, Yongin-si, Gyeonggi-do 446-712, Republic of Korea.
authors.forename: Suk Jun
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Division of Materials Science and Engineering, Hanyang University, Seoul 133-791, Republic of Korea.
authors.forename: Hyeun Hwan
authors.initials: HH
authors.lastname: An
authors.affiliation: Division of Materials Science and Engineering, Hanyang University, Seoul 133-791, Republic of Korea.
authors.forename: Hee-Soo
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Division of Materials Science and Engineering, Hanyang University, Seoul 133-791, Republic of Korea.
authors.forename: Yongdeok
authors.initials: Y
authors.lastname: Kim
authors.affiliation: Division of Materials Science and Engineering, Hanyang University, Seoul 133-791, Republic of Korea. Electronic address: csyoon@hanyang.ac.kr.
authors.forename: Chong Seung
authors.initials: CS
authors.lastname: Yoon
mesh_terms: D003903:Deuterium / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D010713:Phosphatidylcholines / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000737:chemistry*
chemical_list: D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010743:Phospholipids; D014867:Water; D003903:Deuterium; C017251:1,2-oleoylphosphatidylcholine
keywords: Interlayer water; Lipid bilayer; Molecular dynamics simulation