title: Therapeutic drug monitoring in voriconazole-associated hyponatremia.
abstract: Voriconazole is a second generation triazole antifungal agent and the first choice therapy for invasive aspergillosis (IA). Although voriconazole may be associated with many adverse events, hyponatremia has been rarely reported which potentially could result in death. Therapeutic drug monitoring (TDM) and individualization of therapy by measuring voriconazole plasma concentrations improved the efficacy and safety in patients. We report the effect of TDM to adjust voriconazole dosage in a voriconazole-related hyponatremia patient.
authors.affiliation: The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China ; The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Ren-Ai
authors.initials: RA
authors.lastname: Xu
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Shuang-Li
authors.initials: SL
authors.lastname: Zheng
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Xiao
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Xue-Ding
authors.initials: XD
authors.lastname: Cai
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Xi-Xi
authors.initials: XX
authors.lastname: Lai
authors.affiliation: The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Guan-Yang
authors.initials: GY
authors.lastname: Lin
authors.affiliation: The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Lu-Feng
authors.initials: LF
authors.lastname: Hu
authors.affiliation: The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Chun-Hong
authors.initials: CH
authors.lastname: Zhang
authors.affiliation: The Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Zhi-Sheng
authors.initials: ZS
authors.lastname: Xu
authors.affiliation: The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Zhang
keywords: Hyponatremia; Invasive pulmonary aspergillosis; Therapeutic drug monitoring; Voriconazole