title: Evaluation of adults with acute viral hepatitis a and review of the literature.
abstract: OBJECTIVE
  In developing countries HAV infection is very common in the first years of life and it is often asymptomatic. However especially in regions of intermediate endemicity, exposure to the virus may delay and outbreaks of hepatitis A may be encountered in adults. The aim of this study is to evaluate the clinical and laboratory findings and risk factors of adults with acute viral hepatitis A.
  
  
  METHODS
  In present study we evaluated 203 patient with acute viral hepatitis A, who were admitted to four different hospitals of three cities of Turkey between January 2000-December 2011, retrospectively. The diagnosis of acute viral hepatitis A was performed by laboratory findings and clinically.
  
  
  RESULTS
  In a total of 203 patients, 120 (59.1%) patients were male and 83 (40.9%) were female. Mean age of cases with acute viral hepatitis A was 24.7 +11.8 years (ranged 15 to 82 years old). Acute viral hepatitis A were seen in patient who were 15-20 years and 21-30 years old, commonly. Jaundice (74%), fatigue (68%), nausea- vomiting (56%) and dark urine (48%) were the most common symptoms in cases. Prolonged cholestasis (6.8%) was the most common atypical manifestation. Prolonged jaundice was more frequent in the cases with positive HBsAg (P < 0.001).
  
  
  CONCLUSIONS
  Acute viral hepatitis A can cause atypical presentations such as prolonged cholestasis, acute kidney injury and fulminant hepatitis. Some precautions such as routine vaccination program, improvement of hygiene conditions and informing people about it, should be taken for reducing of acute viral hepatitis A infection incidence.
authors.affiliation: Departments of Infectious Disease and Clinical Microbiology, Dicle University, Diyarbakir, Turkey.
authors.forename: R
authors.initials: R
authors.lastname: Tekin
authors.forename: I
authors.initials: I
authors.lastname: Yolbas
authors.forename: T
authors.initials: T
authors.lastname: Dal
authors.forename: Ö
authors.initials: Ö
authors.lastname: Demirpençe
authors.forename: S
authors.initials: S
authors.lastname: Kaya
authors.forename: F
authors.initials: F
authors.lastname: Bozkurt
authors.forename: Ö
authors.initials: Ö
authors.lastname: Deveci
authors.forename: M K
authors.initials: MK
authors.lastname: Çelen
authors.forename: A
authors.initials: A
authors.lastname: Tekin
mesh_terms: D000208:Acute Disease; D058186:Acute Kidney Injury / Q000821:virology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology* / Q000503:physiopathology; D006760:Hospitalization; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult