title: Successful management of chronic refractory immune thrombocytopenia with laparoscopic splenectomy in a patient with acute promyelocytic leukemia.
abstract: Acute promyelocytic leukemia (APL) is a particular type of acute myeloid leukemia with characteristic biological and clinical features, the frequent association at diagnosis of a severe hemorrhagic diathesis. Immune thrombocytopenia (ITP) is a common autoimmune disease characterized by low platelet counts and an increased risk of bleeding. Here we present a patient with the diagnosis of APL who achieved and maintained a remission with an induction consisting of idarubicin and ATRA, and then developed corticosteroid refractory ITP which is successfully treated with laparoscopic splenectomy.
authors.affiliation: Department of Hematology, Diyarbakir Training and Research Hospital, Diyarbakir, Turkey.
authors.forename: Ahmet Emre
authors.initials: AE
authors.lastname: Eskazan
authors.affiliation: Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Salihoglu
authors.affiliation: Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Gulturk
authors.affiliation: Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Seniz Ongoren
authors.initials: SO
authors.lastname: Aydin
authors.affiliation: Department of Pathology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Nukhet
authors.initials: N
authors.lastname: Tuzuner
authors.affiliation: Division of Hematology, Department of Internal Medicine, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Yildiz
authors.initials: Y
authors.lastname: Aydin
keywords: APL; Acute promyelocytic leukemia; ITP; Immune thrombocytopenia; Splenectomy