title: Plasma sE-selectin level is positively correlated with neutrophil count and diastolic blood pressure in Japanese men.
abstract: Increased levels of circulating soluble type of E-selectin (sE-selectin), neutrophil counts and blood pressure are associated with the development of cardiovascular diseases (CVD). In this study, we conducted a cross-sectional study of men who participated in health check-ups, and selected those who were not diagnosed with or being treated for metabolic diseases such as diabetes, hypertension and lipid abnormality according to the health check-ups. We measured their basic clinical parameters including blood pressure and neutrophil count, plasma sE-selectin concentration and lifestyle factors, and assessed their interrelations by multivariate linear regression (MLR) analysis. A total of 351 subjects aged 47.5±8.41 (range, 30-64) y were recruited. Significantly correlated with sE-selectin concentration were neutrophil count, diastolic blood pressure (DBP), and systolic blood pressure (SBP) (Pearson's correlation coefficient, 0.194, 0.220 and 0.175, respectively). MLR analysis showed that sE-selectin concentration was independently positively related with DBP and neutrophil count, whereas neutrophil count was positively associated with sE-selectin concentration but not DBP. DBP, but not SBP, was independently positively correlated with sE-selectin concentration but not neutrophil count. These results indicate that circulating sE-selectin concentration may be a biomarker for indicating subsequent development of metabolic diseases, in particular CVD, from a healthy state.
authors.affiliation: Laboratory of Nutritional Physiology and Global COE Program, University of Shizuoka, Graduate School of Nutritional and Environmental Sciences.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Seiya
authors.initials: S
authors.lastname: Inoue
authors.forename: Rie
authors.initials: R
authors.lastname: Miyauchi
authors.forename: Yasumi
authors.initials: Y
authors.lastname: Misaki
authors.forename: Masaya
authors.initials: M
authors.lastname: Shimada
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Kasezawa
authors.forename: Kazushige
authors.initials: K
authors.lastname: Tohyama
authors.forename: Toshinao
authors.initials: T
authors.lastname: Goda
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000737:chemistry; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D019040:E-Selectin / Q000097:blood* / Q000737:chemistry; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D007564:Japan / Q000453:epidemiology; D007958:Leukocyte Count; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils / Q000276:immunology*; D058246:Prehypertension / Q000097:blood* / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D012307:Risk Factors; D012995:Solubility; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D019040:E-Selectin; C546936:SELE protein, human