title: The changes of platelet and platelet activation markers in acute coronary syndrome patients.
abstract: BACKGROUND
  To investigate the changes of platelet microparticle (PMPs), monocyte-platelet aggregation (MPAs), and the platelet membrane glycoprotein GPIIb/IIIa ligands (PAC-1) and P-hormone (CD62P) activation ratio changes in acute coronary syndrome (ACS) patients.
  
  
  METHODS
  92 patients were divided into ACS group (54 cases) and coronary angiography negative group (38 cases). 30 cases of age/gender matched healthy control group were recruited. The flow cytometry analysis in each group of PMPs, the MPAs expression of CD62P, GPIIb/IIIa activation ratio, and ROC curve were performed to evaluate the sensitivity and specificity of each parameter.
  
  
  RESULTS
  The healthy control group showed MPAs 5.94 +/- 1.93%, PMPs 1.89 +/- 0.53%, and PAC-1 2.86 +/- 0.93%, the coronary angiography-negative group showed MPAs 11.97 +/- 4.92%, PMPs 3.08 +/- 1.38%, and PAC-1 3.38 +/- 0.92%, and the ACS group showed MPAs 46.27 +/- 17.74%, PMPs 5.28 +/- 2.44%, and PAC-1 5.34 +/- 2.44%. In the ACS group, the area under the ROC curve of each indicator for identifying suspected ACS patients were MPAs (0.952), PMPs (0.807), PAC-1 (0.770), and CD62p (0.656). MPAs showed the highest sensitivity (94.4%) and specificity (84.2%) for the diagnosis of ACS.
  
  
  CONCLUSIONS
  acute coronary syndrome, platelet microparticle, monocyte-platelet aggregation, CD62P, GPIIb/IIIa.
authors.affiliation: Department of Clinical Analysis, The Fourth People's Hospital, Xiaoshan District, Hangxhou 311225, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Fang
authors.affiliation: Department of Clinical Analysis, The Third People's Hospital, Wenzhou China.
authors.forename: Jiayong
authors.initials: J
authors.lastname: Zheng
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D001792:Blood Platelets; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation
chemical_list: D015415:Biomarkers