title: Colorectal motor and sensory function after hysterectomy.
abstract: OBJECTIVE
  Women may develop constipation after hysterectomy. The pathophysiology and underlying mechanisms are poorly understood. They may originate from either neural damage of rectum and colon or changes in anatomical constellation of the remaining pelvic organs. The aim of this study is to evaluate sensory and motor functions of rectum and colon in women with newly developed constipation after hysterectomy in comparison with women without constipation and healthy controls after hysterectomy .
  
  
  METHODS
  Barostat measurements were performed in posthysterectomy women with constipation (PH-C), without constipation (PH-NC), and healthy controls (n = 10, every group). Outcome measures were rectal and colonic compliance (millilitre per millimetre of mercury), rectocolonic perception in reaction to mechanical distension (millimetre; VAS scores) and rectocolonic reflex (millilitre per millimetre of mercury).
  
  
  RESULTS
  No differences in rectal or colonic compliance were observed. Urge perception due to rectal distension increased significantly in controls (from 7 ± 5 to 41 ± 10 mm; p < 0.05) and PH-NC group (from 3 ± 1 to 24 ± 9 mm; p < 0.05), but not in PH-C patients (1 ± 1 to 11 ± 5 mm; ns). In healthy controls and the PN-NC group, respectively, 100 and 70 % of subjects reached the minimal threshold value for urge of 10 mm during the isobaric distension sequence. In the PH-C group, only two subjects (20 %) reached this threshold (p < 0.05). Rectal pain perception, phasic colonic motility and the rectocolonic reflex were intact in all three groups.
  
  
  CONCLUSIONS
  Colorectal motor and sensory function is generally well preserved in women with constipation after hysterectomy. It is unlikely that the symptom of constipation after hysterectomy has been caused by iatrogenic neuronal damage in these patients.
authors.affiliation: Department of Gastroenterology, Maastricht University Medical Center, Maastricht, The Netherlands, evanhoboken@rkz.nl.
authors.forename: Eduard A
authors.initials: EA
authors.lastname: van Hoboken
authors.forename: Frederik G M
authors.initials: FG
authors.lastname: Timmermans
authors.forename: Patrick P J
authors.initials: PP
authors.lastname: van der Veek
authors.forename: Philomeen T
authors.initials: PT
authors.lastname: Weyenborg
authors.forename: Ad A M
authors.initials: AA
authors.lastname: Masclee
mesh_terms: D000328:Adult; D003106:Colon / Q000294:innervation / Q000503:physiopathology*; D003248:Constipation / Q000209:etiology*; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008875:Middle Aged; D010465:Perception; D011312:Pressure; D012007:Rectum / Q000294:innervation / Q000503:physiopathology*; D012677:Sensation / Q000502:physiology*