title: Synthesis and characterization of a POSS-PEG macromonomer and POSS-PEG-PLA hydrogels for periodontal applications.
abstract: A novel water-soluble macromonomer based on octavinyl silsesquioxane has been synthesized and contains vinyl-terminated PEG 400 in each of the eight arms to promote water solubility. The macromonomer was characterized by NMR and FTIR and its aqueous solution properties examined. In water it exhibits an LCST with a cloud point at 23 °C for a 10 wt % aqueous solution. It is surface active with a CMC of 1.5 × 10(-5) M in water and in 20:80 v/v acetone/water the CMC is 7.1 × 10(-5) M, and TEM images showed spherical 22 nm aggregates in aqueous solution above the CMC. The macromonomer was copolymerized in a 20:80 v/v acetone/water mixture with a vinyl-terminated, triblock copolymer of lactide-PEG-lactide to form a library of cross-linked hydrogels that were designed for use as scaffolds for alveolar bone repair. The cross-linked copolymer networks were shown to contain a range of nm-μm sized pores and their swelling properties in water and PBS at pH 7.4 were examined. At pH 7.4 the hydrogel networks undergo a slow hydrolysis with the release of principally PEG and lactic acid fragments. The hydrogels were shown to be noncytotoxic toward fibroblast cultures at pH 7.4, both initially (days 1-5) and after significant hydrolysis had taken place (days 23-28).
authors.affiliation: Australian Institute for Bioengineering and Nanotechnology, ‡Centre for Advanced Imaging, ∥School of Chemistry and Molecular Biochemistry, and §School of Dentistry, The University of Queensland , Brisbane Queensland 4072, Australia.
authors.forename: David K
authors.initials: DK
authors.lastname: Wang
authors.forename: Srinivas
authors.initials: S
authors.lastname: Varanasi
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Strounina
authors.forename: David J T
authors.initials: DJ
authors.lastname: Hill
authors.forename: Anne L
authors.initials: AL
authors.lastname: Symons
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Whittaker
authors.forename: Firas
authors.initials: F
authors.lastname: Rasoul
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000737:chemistry* / Q000166:cytology; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D017646:Organosilicon Compounds / Q000737:chemistry*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D051381:Rats; D011917:Rats, Inbred Lew; D013499:Surface Properties
chemical_list: D020100:Hydrogels; D046911:Macromolecular Substances; D017646:Organosilicon Compounds; C521417:polyhedraloligosilsesquioxane; D011092:Polyethylene Glycols