title: Interstitial brachytherapy for eyelid carcinoma. Outcome analysis in 60 patients.
abstract: BACKGROUND
  Eyelid cancer is a therapeutic challenge due to the cosmetic and functional implications of this anatomical region and the objectives of therapy are tumor control, functional and cosmetic outcome.
  
  
  OBJECTIVE
  The present study was performed to analyze local control, toxicity, functional and cosmetic results in patients with eyelid carcinoma treated by interstitial brachytherapy.
  
  
  METHODS
  In this study 60 patients with eyelid carcinoma were treated by interstitial brachytherapy using iridium ((192)Ir) wires with a linear activity of 1.2-1.7 mCi/cm. The prescription dose was 51-70 Gy (mean 65 Gy, median 66 Gy).
  
  
  RESULTS
  Of the 60 patients 51 (85.0 %) had received no prior treatment, 4 (6.7 %) had received previous surgery with positive or close margins and 5 (8.3 %) had suffered local recurrence after surgery. Of the tumors 52 (86.7 %) were basal cell carcinoma, 7 (11.7 %) squamous cell carcinoma and 1 (1.7 %) Merkel cell carcinoma. Clinical stage of the 51 previously untreated tumors was 38 T1N0, 12 T2N0 and 1 T3N0. Mean follow-up was 92 months (range 6-253 months). Local control was maintained in 96.7 % of patients. Late effects higher than grade 2 were observed in 3.0 % of cases. Functional and cosmetic outcomes were optimal in 68.4 % of patients.
  
  
  CONCLUSIONS
  Interstitial brachytherapy for carcinoma of the eyelid can achieve local control, cosmetic and functional results comparable to those of surgery.
authors.affiliation: Division of Radiotherapy, University Hospital "Maggiore della Carità", via Solaroli, 17, 28100, Novara, Italy, krengli@med.unipmn.it.
authors.forename: M
authors.initials: M
authors.lastname: Krengli
authors.forename: L
authors.initials: L
authors.lastname: Masini
authors.forename: A M
authors.initials: AM
authors.lastname: Comoli
authors.forename: E
authors.initials: E
authors.lastname: Negri
authors.forename: L
authors.initials: L
authors.lastname: Deantonio
authors.forename: A
authors.initials: A
authors.lastname: Filomeno
authors.forename: G
authors.initials: G
authors.lastname: Gambaro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000532:radiotherapy; D015266:Carcinoma, Merkel Cell / Q000473:pathology / Q000532:radiotherapy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy; D003299:Cooperative Behavior; D004954:Esthetics; D005142:Eyelid Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033183:Interdisciplinary Communication; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D016896:Treatment Outcome
chemical_list: D007496:Iridium Radioisotopes