title: [Multiple sclerosis and endothelial dysfunction (a review)].
abstract: The endothelium plays an important role in the maintenance of vascular homeostasis, the tone and anatomical structure of the vascular wall. It is an essential component of the blood-brain barrier. In adverse conditions, damaged endothelium initiates many pathological processes in the human organism and plays a key role in the pathogenesis of a number of systemic diseases including multiple sclerosis. In this review, we discussed in detail the concepts of structural and functional features of a healthy endothelium and endothelial dysfunction, and present the basic theory of the damage mechanism of the blood-brain barrier and the role of endothelial cells, adhesion molecules, cerebral hypoperfusion in multiple sclerosis.
authors.forename: N N
authors.initials: NN
authors.lastname: Spirina
authors.forename: N N
authors.initials: NN
authors.lastname: Spirin
authors.forename: O A
authors.initials: OA
authors.lastname: Fadeeva
authors.forename: E G
authors.initials: EG
authors.lastname: Shipova
authors.forename: A N
authors.initials: AN
authors.lastname: Boĭko
mesh_terms: D002560:Cerebrovascular Circulation / Q000502:physiology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D009103:Multiple Sclerosis / Q000503:physiopathology*; D014664:Vasodilation / Q000502:physiology*