title: Evaluation of MMP-9 and TIMP-1 Levels of the Patients with Nasal Polyposis After Corticosteroid Therapies.
abstract: The aim of this study is to evaluate the effects of intrapolyp, systemic and local corticosteroid treatment modalities on MMP-9 and TIMP-1 level in polyp tissues. This study included 71 patients and five groups. Group A treated with oral methylprednisolone, Group B, treated with topical steroid spray, Group C treated with intralesional triamcinolone acetonide, Group D patients with nasal polyposis who has not given any medication, Group E had surgery for concha bullosa without nasal polyp disease. Samples from group A were collected endoscopically 1 day after treatment was stopped. Group B samples were collected at the end of the first month. Video guided sample collection from Group C was also performed on the 7th day after treatment. MMP-9 and TIMP-1 levels were measured by Enzyme-linked immunosorbent assay method. When we compared the MMP-9 levels of all groups, there were no significant differences. There was significant difference of TIMP-1 level between Groups C and E (pC-E = 0.0019), however there was no difference among the level of the other groups. When MMP-9/TIMP1 rates of all groups were compared, there were significant difference between Group A and D (pA-D = 0.005) and between Group A and E, also between Group C and E. Our study is the first study to evaluate the effects of different corticosteroid treatment modalities on MMP-9 and TIMP-1 in nasal polyps and concluded that corticosteroid did not do a significant impact on this pathway.
authors.affiliation: Department of Otorhinolaryngology, GATA Haydarpasa Training Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Cincik
authors.affiliation: Department of Otorhinolaryngology, GATA Haydarpasa Training Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Evren
authors.initials: E
authors.lastname: Erkul
authors.affiliation: Department of Otorhinolaryngology, GATA Haydarpasa Training Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Dogan
authors.initials: D
authors.lastname: Pinar
authors.affiliation: Department of Biochemistry, GATA Haydarpasa Training Hospital, Uskudar, Istanbul, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Ipcioglu
authors.affiliation: Department of Otorhinolaryngology, GATA Haydarpasa Training Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Atila
authors.initials: A
authors.lastname: Gungor
authors.affiliation: Department of Otorhinolaryngology, GATA Haydarpasa Training Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Cekin
authors.affiliation: Department of Otorhinolaryngology, GATA Haydarpasa Training Hospital, Uskudar, 34668 Istanbul, Turkey.
authors.forename: Adem
authors.initials: A
authors.lastname: Cakmak
keywords: Corticosteroid; Matrix metalloproteinase inhibitor; Matrix metalloproteinase-9; Nasal polyposis; Therapy