title: Dendrite injury triggers DLK-independent regeneration.
abstract: Axon injury triggers regeneration through activation of a conserved kinase cascade, which includes the dual leucine zipper kinase (DLK). Although dendrites are damaged during stroke, traumatic brain injury, and seizure, it is not known whether mature neurons monitor dendrite injury and initiate regeneration. We probed the response to dendrite damage using model Drosophila neurons. Two larval neuron types regrew dendrites in distinct ways after all dendrites were removed. Dendrite regeneration was also triggered by injury in adults. Next, we tested whether dendrite injury was initiated with the same machinery as axon injury. Surprisingly, DLK, JNK, and fos were dispensable for dendrite regeneration. Moreover, this MAP kinase pathway was not activated by injury to dendrites. Thus, neurons respond to dendrite damage and initiate regeneration without using the conserved DLK cascade that triggers axon regeneration.
authors.affiliation: Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Stone
authors.affiliation: Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Richard M
authors.initials: RM
authors.lastname: Albertson
authors.affiliation: Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.affiliation: Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA. Electronic address: mur22@psu.edu.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Rolls
mesh_terms: D000818:Animals; D003712:Dendrites / Q000378:metabolism* / Q000502:physiology; D004330:Drosophila; D020930:MAP Kinase Kinase Kinases / Q000235:genetics / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D009416:Nerve Regeneration
chemical_list: D020930:MAP Kinase Kinase Kinases; C090757:mitogen-activated protein kinase kinase kinase 12