title: [Brain metastasis which appeared during complete response of lung metastatic lesion by sunitinib treatment in a patient with renal cell carcinoma].
abstract: A 59-year-old man underwent radical nephrectomy for left renal cell carcinoma with multiple lung metastases (cT3bN0M1) in May 2010. Pathological diagnosis was clear cell carcinoma, G2 and pT3b. After sunitinib treatment for 7 months computed tomography (CT) revealed complete response of lung lesions and the treatment was continued. After 10 months, the patient complained of right hemiplegia. Brain magnetic resonance imaging (MRI) revealed a 3 cm tumor in his frontal lobe of cerebrum. He underwent surgical resection of the tumor and pathological diagnosis was metastatic renal cell carcinoma. He has been well without local recurrence or distant metastasis for 18 months.
authors.affiliation: The Department of Urology, Hoshigaoka Koseinenkin Hospital.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Morizawa
authors.affiliation: The Department of Urology, Hoshigaoka Koseinenkin Hospital.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Momose
authors.affiliation: The Department of Urology, Hoshigaoka Koseinenkin Hospital.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Toyoshima
authors.affiliation: The Department of Urology, Hoshigaoka Koseinenkin Hospital.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takada
authors.affiliation: The Department of Urology, Hoshigaoka Koseinenkin Hospital.
authors.forename: Ken
authors.initials: K
authors.lastname: Fujimoto
authors.affiliation: The Department of Urology, Hoshigaoka Koseinenkin Hospital.
authors.forename: Nobuo
authors.initials: N
authors.lastname: Oyama
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000556:secondary*; D002292:Carcinoma, Renal Cell / Q000556:secondary*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000627:therapeutic use*; D012074:Remission Induction; D000077210:Sunitinib
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib