title: Association between polymorphisms within the susceptibility region 8q24 and breast cancer in a Chinese population.
abstract: Recent publications have found associations between single-nucleotide polymorphisms (SNPs) in 8q24 and the risk of breast cancer (BC) in some populations, but the conclusions are inconsistent. In order to further investigate the association between variants in this region and BC risk in Chinese population, we conducted an independent hospital-based case-control study to discern the effects of these SNPs on BC risk. We genotyped three 8q24 SNPs (rs13281615, rs6983267, and rs9642880) in 485 cases and 530 cancer-free controls. The results indicated that the rs13281615 G allele significantly increased BC risk, with an odds ratio (OR) of 1.23 (95% confidence interval (CI) = 1.03-1.46) under the allelic model. Besides, stratification analysis reported that the significant association remained in the estrogen receptor (ER)+/progesterone receptor (PR)+ subgroup with a P value of 0.007 under the allelic model (OR = 1.33, 95% CI = 1.08-1.63). For the rs9642880 variant, only a feeble association was observed for the GT genotype compared with the GG genotype (OR = 1.33, 95% CI = 1.01-1.74). In addition, there was a negligible association between rs6983267 and BC risk in the ER-/PR- subgroup. However, no significant finding was observed in the overall participants. The findings suggested that polymorphisms in 8q24 may contribute to susceptibility to BC risk. However, functional studies are warranted to further elucidate the mechanisms of the association.
authors.affiliation: State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, Wuhan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Pengfei
authors.initials: P
authors.lastname: Yi
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Ming
authors.forename: Beibei
authors.initials: B
authors.lastname: Zhu
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Na
authors.initials: N
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Shi
authors.forename: Juntao
authors.initials: J
authors.lastname: Ke
authors.forename: Qunzi
authors.initials: Q
authors.lastname: Zhao
authors.forename: Xuzai
authors.initials: X
authors.lastname: Lu
authors.forename: Xueqiong
authors.initials: X
authors.lastname: Xun
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Ranran
authors.initials: R
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Guo
authors.forename: Rong
authors.initials: R
authors.lastname: Zhong
authors.forename: Liming
authors.initials: L
authors.lastname: Liang
authors.forename: Tao
authors.initials: T
authors.lastname: Huang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Miao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction