title: Advances and future of Radiation Oncology.
abstract: OBJECTIVE
  Review of recent advances and vision for future developments in clinical practice of Radiation Oncology.
  
  
  BACKGROUND
  There have been substantial research and technological developments in Radiation Oncology over the past 40 years.
  
  
  METHODS
  The relevant literature was reviewed and the authors offer their perspective on future opportunities for advancement in Radiation Oncology.
  
  
  CONCLUSIONS
  Significant innovative technological developments have been introduced in the practice of Radiation Oncology, with more precise target delineation and tracking and three dimensional treatment planning, optimal delivery of radiation therapy to the target and lower doses to surrounding Organs at Risk. This dose optimization and adaptive therapy have enhanced the role of Radiation Therapy to more effectively treat patients with cancer. Further creativity and refinements will continue to advance the field into new applications of ionizing radiations in cancer therapy.
authors.affiliation: Department of Radiation Oncology, Mallinckrodt Institute of Radiology/Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8224, Saint Louis, MO 63110 USA.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Perez
authors.affiliation: Department of Radiation Oncology, Mallinckrodt Institute of Radiology/Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8224, Saint Louis, MO 63110 USA.
authors.forename: Sasa
authors.initials: S
authors.lastname: Mutic
keywords: Advances; Future; Radiation Oncology