title: Endogenous IFNλ in viral hepatitis patients.
abstract: Besides type I interferons (IFNs), type III IFNs, including IFNλ1 (interleukin-29 [IL-29]), possess potent antiviral activity. In patients infected with the hepatitis C virus (HCV), it has been demonstrated that viral clearance is associated with genetic variation near the IFNλ3 (IL-28B) gene. The rapid influx of research being conducted on this family of cytokines has led to several inconsistencies and controversies, including the possible correlation of serum cytokine levels with disease in chronic viral hepatitis patients. In a detailed study, well-characterized cohorts of patients with HBV and HCV were evaluated with 3 different immunoassays, and no differences in the levels of serum IFNλ were observed between patient groups, disease stages, or clinical parameters.
authors.affiliation: 1 Liver Unit, Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam , Rotterdam, The Netherlands .
authors.forename: Rik A
authors.initials: RA
authors.lastname: de Groen
authors.forename: Fiona
authors.initials: F
authors.lastname: Mcphee
authors.forename: Jacques
authors.initials: J
authors.lastname: Friborg
authors.forename: Harry L A
authors.initials: HL
authors.lastname: Janssen
authors.forename: André
authors.initials: A
authors.lastname: Boonstra
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000503:physiopathology; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D007371:Interferon-gamma