title: Biodegradable borosilicate bioactive glass scaffolds with a trabecular microstructure for bone repair.
abstract: Three-dimensional porous scaffolds of a borosilicate bioactive glass (designated 13-93B1), with the composition 6Na2O-8K2O-8MgO-22CaO-18B2O3-36SiO2-2P2O5 (mol%), were prepared using a foam replication technique and evaluated in vitro and in vivo. Immersion of the scaffolds for 30 days in a simulated body fluid in vitro resulted in partial conversion of the glass to a porous hydroxyapatite composed of fine needle-like particles. The capacity of the scaffolds to support bone formation in vivo was evaluated in non-critical sized defects created in the femoral head of rabbits. Eight weeks post-implantation, the scaffolds were partially converted to hydroxyapatite, and they were well integrated with newly-formed bone. When loaded with platelet-rich plasma (PRP), the scaffolds supported bone regeneration in segmental defects in the diaphysis of rabbit radii. The results indicate that these 13-93B1 scaffolds, loaded with PRP or without PRP, are beneficial for bone repair due to their biocompatibility, conversion to hydroxyapatite, and in vivo bone regenerative properties.
authors.affiliation: Department of Materials Science and Engineering, Tongji University, Shanghai 200092, China.
authors.forename: Yifei
authors.initials: Y
authors.lastname: Gu
authors.affiliation: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Materials Science and Engineering, Tongji University, Shanghai 200092, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Department of Materials Science and Engineering, and Center for Bone and Tissue Repair and Regeneration, Missouri University of Science and Technology, Rolla, MO 65409-0340, USA.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Materials Science and Engineering, and Center for Bone and Tissue Repair and Regeneration, Missouri University of Science and Technology, Rolla, MO 65409-0340, USA.
authors.forename: Mohamed N
authors.initials: MN
authors.lastname: Rahaman
authors.affiliation: Department of Materials Science and Engineering, Tongji University, Shanghai 200092, China. Electronic address: whhuang@tongji.edu.cn.
authors.forename: Wenhai
authors.initials: W
authors.lastname: Huang
authors.affiliation: Department of Orthopaedics & Traumatology, The University of Hong Kong, 999077, Hong Kong, China.
authors.forename: Haobo
authors.initials: H
authors.lastname: Pan
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001861:Bone Regeneration / Q000187:drug effects*; D005270:Femur Head / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D020007:Implants, Experimental; D008297:Male; D011817:Rabbits; D011859:Radiography; D011884:Radius / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D012996:Solutions; D054457:Tissue Scaffolds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: C000591613:6Na2O-8K2O-8MgO-22CaO-18B2O3-36SiO2-2P2O5 glass; D001672:Biocompatible Materials; D012996:Solutions
keywords: Bioactive glass; Bone regeneration; In vitro degradation; Platelet-rich plasma; Polymer foam replication; Scaffold