title: Incidence of hepatocellular carcinoma in HIV-infected patients with cirrhosis: a prospective study.
abstract: : This study assesses the incidence of hepatocellular carcinoma (HCC) in a prospective cohort of HIV-infected patients, the majority receiving antiretroviral therapy, with liver cirrhosis from different etiologies, enrolled between 2004 and 2005 with median follow-up of 5 years. We followed 371 patients, 25.6% with decompensated cirrhosis at baseline. The incidence rate of HCC was 6.72 per 1000 person-years [95% confidence interval (CI): 2.6 to 10.9]. There was a trend toward a higher cumulative probability of developing HCC at 6 years of follow-up (considering death and liver transplant as competing risks) in patients with decompensated versus compensated cirrhosis at baseline (6% vs. 2%, P < 0.06).
authors.affiliation: *HIV Unit, Service of Internal Medicine, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain; †Service of Infectious Diseases, Hospital Clínic/IDIBAPS, University of Barcelona, Barcelona, Spain; ‡Service of Infectious Diseases, Hospital Ramón y Cajal, Madrid, Spain; §HIV Clinical Unit, Internal Medicine Department and Fundació de la Lluita contra la SIDA, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Barcelona, Spain; ‖Unit of Infectious Diseases, Hospital Donostia, Donostia-San Sebastián, Spain; ¶Infectious Diseases and HIV Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain; #HIV Unit, Hospital 12 de Octubre and Universidad Europea de Madrid, Madrid, Spain; **Unit of Infectious Diseases, Hospital General Universitario de Valencia, Valencia, Spain; and ††Service of Internal Medicine, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Montes Ramírez
authors.forename: José M
authors.initials: JM
authors.lastname: Miró
authors.forename: Carmen
authors.initials: C
authors.lastname: Quereda
authors.forename: Antoni
authors.initials: A
authors.lastname: Jou
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: von Wichmann
authors.forename: Juan
authors.initials: J
authors.lastname: Berenguer
authors.forename: Juan J
authors.initials: JJ
authors.lastname: González-García
authors.forename: Asunción
authors.initials: A
authors.lastname: Hernando
authors.forename: Enrique
authors.initials: E
authors.lastname: Ortega
authors.forename: José
authors.initials: J
authors.lastname: Sanz
authors.forename: José R
authors.initials: JR
authors.lastname: Arribas
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000150:complications / Q000209:etiology*; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D011446:Prospective Studies; D012307:Risk Factors