title: Correlation between positive rate and number of biopsy samples on urease test in childhood Helicobacter pylori infection.
abstract: To identify the correlation between the number of gastric biopsy samples and the positive rate, we compared the results of urease test using one and three biopsy samples from each 255 children who underwent gastroduodenoscopy at Gyeongsang National University Hospital. The children were divided into three age groups: 0-4, 5-9, and 10-15 yr. The gastric endoscopic biopsies were subjected to the urease test. That is, one and three gastric antral biopsy samples were collected from the same child. The results of urease test were classified into three grades: Grade 0 (no change), 1 (6-24 hr), 2 (1-6 hr), and 3 (<1 hr). The positive rate of urease test was increased by the age with no respect to the number of gastric biopsy samples (one biopsy P = 0.001, three biopsy P < 0.001). The positive rate of the urease test was higher on three biopsy samples as compared with one biopsy sample (P < 0.001). The difference between one and three biopsy samples was higher in the children aged 0-9 yr. Our results indicate that the urease test might be a more accurate diagnostic modality when it is performed on three or more biopsy samples in children.
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Seo
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Ji Sook
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Jung Sook
authors.initials: JS
authors.lastname: Yeom
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Jae-Young
authors.initials: JY
authors.lastname: Lim
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Chan-Hoo
authors.initials: CH
authors.lastname: Park
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Hyang-Ok
authors.initials: HO
authors.lastname: Woo
authors.affiliation: Department of Microbiology, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Seung-Chul
authors.initials: SC
authors.lastname: Baik
authors.affiliation: Department of Microbiology, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Woo-Kon
authors.initials: WK
authors.lastname: Lee
authors.affiliation: Department of Microbiology, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Myung-Je
authors.initials: MJ
authors.lastname: Cho
authors.affiliation: Department of Microbiology, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Kwang-Ho
authors.initials: KH
authors.lastname: Rhee
authors.affiliation: Department of Pediatrics, Gyeongsang National University School of Medicine, Gyeongsang Institute of Health Sciences, Jinju, Korea.
authors.forename: Hee-Shang
authors.initials: HS
authors.lastname: Youn
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004384:Duodenoscopy; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011706:Pyloric Antrum / Q000382:microbiology; D014510:Urease / Q000032:analysis*
chemical_list: D014510:Urease
keywords: Age; Helicobacter pylori Infection; Histopathology; Urease Test