title: Correlation of PUV and SUV in the extremities while using PEM as a high-resolution positron emission scanner.
abstract: OBJECTIVE
  Owing to its unique configuration of two adjustable plate detectors positron emission mammography, or PEM, could theoretically also function as a high-resolution positron emission scanner for the extremities or neck. PEM quantitates its activity via a "PEM uptake value," or PUV, and although its relationship to the standardized uptake value, or SUV, has been demonstrated in the breasts, to our knowledge there are no studies validating PUV in other sites such as the extremities.
  
  
  METHODS
  This was a retrospective chart review of two separate protocols of a total of 15 patients. The patients all had hypermetabolic lesions in the extremities or neck on imaging with PET/CT and were sent after their PET/CT to PEM for further imaging. Owing to the sequential nature of these examinations no additional radiotracer was administered.
  
  
  RESULTS
  Spearman's rank order correlation was calculated between the PUVmax obtained from PEM images, and the SUVmax for all. Spearman's rank order correlation for all sites was 0.42, which is not significantly different from 0 (p = 0.13). When neck lesions were excluded from the group, there was a strong and statistically significant correlation between PUVmax and SUVmax, with Spearman's rank correlation of 0.73, and significantly different from 0 (p = 0.0068).
  
  
  CONCLUSIONS
  The correlation of PUV and SUV in the extremities indicates the potential use of PEM as a semiquantitative, high-resolution positron emission scanner and warrants further investigation, especially in the realms of disease processes that often present in the extremities, such as melanoma, osteomyelitis, and arthritis, as well as playing a role in the imaging of patients with metallic hardware post-limb salvage surgery.
authors.affiliation: Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, saniargilani@gmail.com.
authors.forename: Sania
authors.initials: S
authors.lastname: Rahim
authors.forename: Osama
authors.initials: O
authors.lastname: Mawlawi
authors.forename: Patricia
authors.initials: P
authors.lastname: Fox
authors.forename: Shree
authors.initials: S
authors.lastname: Taylor
authors.forename: Richelle
authors.initials: R
authors.lastname: Millican
authors.forename: Nancy M
authors.initials: NM
authors.lastname: Swanston
authors.forename: J Elliott
authors.initials: JE
authors.lastname: Brown
authors.forename: Eric M
authors.initials: EM
authors.lastname: Rohren
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D005121:Extremities / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000295:instrumentation* / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18