title: [Medication-based therapy of infantile hemangioma and lymphatic malformations].
abstract: The therapy of vascular tumors and malformations should be interdisciplinary and performed according to available guidelines. Infantile hemangiomas (IH) are the most frequent vascular tumors of childhood and do not require treatment in most cases. If the IH is complicated by its location (e.g. facial or genital) or if the lesion threatens to cause loss of function, small localized IH should be treated by laser- or cryotherapy. If the IH is diffuse or rapidly growing it can be successfully treated using the β blocker propranolol. The mechanism underlying the efficacy of this medication-based therapy is not completely understood and this still represents an experimental therapy. The results of molecular studies on vascular malformations have indicated new strategies for medical therapies. However, lymphatic malformations (LM) are still treated by surgery where possible, or sclerotherapy. Further investigations are necessary to determine whether new drugs such as the mTOR inhibitor rapamycin may be effective for treatment of diffuse LM. First case reports seem to be promising.
authors.affiliation: Interdisziplinäre Spezialsprechstunde für Hämangiome und vaskuläre Malformationen, Universitätsklinikum Freiburg, Freiburg, Deutschland, jochen.roessler@uniklinik-freiburg.de.
authors.forename: J
authors.initials: J
authors.lastname: Rössler
authors.forename: F
authors.initials: F
authors.lastname: Braunschweiger
authors.forename: T
authors.initials: T
authors.lastname: Schill
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006391:Hemangioma / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D044148:Lymphatic Abnormalities / Q000188:drug therapy*; D018190:Neoplasm, Lymphatic Tissue / Q000188:drug therapy*; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D020123:Sirolimus / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000903:Antibiotics, Antineoplastic; D014665:Vasodilator Agents; D011433:Propranolol; D020123:Sirolimus