title: Antihyperlipidemic effects of stilbenoids isolated from Morus alba in rats fed a high-cholesterol diet.
abstract: Mulberroside A (MUL) was purified from an ethanol extract of Morus alba root, and oxyresveratrol (OXY) was produced by enzymatic conversion of MUL. Normal rats, Triton WR-1339-induced hyperlipidemic rats, and high-cholesterol diet (HCD)-induced hyperlipidemic rats were orally treated with MUL or OXY (1-5mg/kg/day). MUL and OXY were administered 1h prior to concomitant treatment with Triton WR-1339 for a further 24h, whereas the drugs were administered concurrently with HCD for 4weeks. Oral MUL and OXY pre-treatment vs. water pre-treatment of Triton WR-1339-induced hyperlipidemic rats significantly (p<0.05) reduced the levels of serum lipids in a dose-dependent manner, while high-density lipoprotein cholesterol (HDL-C, or "good" cholesterol) levels were increased. Oral MUL and OXY treatment of HCD-fed rats also showed a significant (p<0.05) dose-dependent decrease in serum lipids, coronary artery risk index (CRI), and atherogenic index (AI), but not HDL-C. Furthermore, MUL and OXY treatment of HCD-induced hyperlipidemic rats demonstrated a significant dose-dependent improvement in the histological features of hepatic fatty degeneration. Aspartate aminotransferase and alanine aminotransferase values in OXY-treated normal rats were not significantly different from those in water-treated control rats. These results indicate that MUL and OXY might be developed as novel antihyperlipidemic agents.
authors.affiliation: Department of Public Health Science, Graduate School, Korea University, Seoul 136-703, South Korea.
authors.forename: Sung-Pil
authors.initials: SP
authors.lastname: Jo
authors.affiliation: Department of Chemical Engineering and Biotechnology, Korea Polytechnic University, Shihung-si, Gyeonggi-do 429-793, South Korea.
authors.forename: Jeong-Keun
authors.initials: JK
authors.lastname: Kim
authors.affiliation: Department of Public Health Science, Graduate School, Korea University, Seoul 136-703, South Korea; Department of Laboratory Medicine, Korea University Guro Hospital, Seoul, South Korea. Electronic address: yhlim@korea.ac.kr.
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Lim
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004187:Disaccharides / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000139:chemically induced; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D031625:Morus / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D002791:Cholesterol, Dietary; D004187:Disaccharides; D000960:Hypolipidemic Agents; D008055:Lipids; D010936:Plant Extracts; D013267:Stilbenes; C420606:mulberroside A; D011092:Polyethylene Glycols; C034912:puag-haad; C016811:tyloxapol
keywords: Antihyperlipidemic activity; Atherogenic index; High-cholesterol diet; Stilbenoids