title: Bone metabolism in anorexia nervosa.
abstract: Anorexia nervosa (AN), a psychiatric disorder predominantly affecting young women, is characterized by self-imposed, chronic nutritional deprivation and distorted body image. AN is associated with a number of medical comorbidities including low bone mass. The low bone mass in AN is due to an uncoupling of bone formation and bone resorption, which is the result of hormonal adaptations aimed at decreasing energy expenditure during periods of low energy intake. Importantly, the low bone mass in AN is associated with a significant risk of fractures and therefore treatments to prevent bone loss are critical. In this review, we discuss the hormonal determinants of low bone mass in AN and treatments that have been investigated in this population.
authors.affiliation: Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Bulfinch 457, Boston, MA, 02114, USA, pkfazeli@partners.org.
authors.forename: Pouneh K
authors.initials: PK
authors.lastname: Fazeli
authors.forename: Anne
authors.initials: A
authors.lastname: Klibanski
mesh_terms: D000856:Anorexia Nervosa / Q000150:complications / Q000378:metabolism*; D015519:Bone Density / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000378:metabolism*; D001862:Bone Resorption / Q000209:etiology / Q000378:metabolism; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D007006:Hypogonadism / Q000209:etiology / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D010012:Osteogenesis / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000378:metabolism
chemical_list: D019382:Human Growth Hormone