title: RES-TOCSY: a simple approach to resolve overlapped ¹H NMR spectra of enantiomers.
abstract: Chiral auxiliaries are used for the NMR spectroscopic study of enantiomers. Often the presence of impurities, overlap of peaks, line broadening and the multiplicity pattern restrict the chiral analysis in the 1D (1)H NMR spectrum. The present study introduces a simple 2D (1)H NMR experiment to unravel the overlapped spectrum. The experiment separates the spectra of enantiomers, thereby allowing the unambiguous assignment of all the coupled peaks and the measurement of enantiomeric excess (ee) from a single experiment even in combinatorial mixtures.
authors.affiliation: NMR Research Centre, Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore-560012, India. nsp@nrc.iisc.ernet.in.
authors.lastname: Lokesh
authors.forename: Sachin Rama
authors.initials: SR
authors.lastname: Chaudhari
authors.forename: N
authors.initials: N
authors.lastname: Suryaprakash
mesh_terms: D004867:Equipment Design; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D009930:Organic Chemicals / Q000737:chemistry*; D011522:Protons; D012015:Reference Standards; D012984:Software; D013237:Stereoisomerism
chemical_list: D009930:Organic Chemicals; D011522:Protons