title: [Study on the liver-protective and choleretic effect of zhizi baipi soup and its disassembled prescription].
abstract: OBJECTIVE
  To investigate the effect of Zhizi Baipi soup and its disassembled prescription on protecting liver and improving choleresis and explore the regularity of Zhizi Baipi soup composition.
  
  
  METHODS
  The model of mouse liver injury induced by carbon tetraehlofide (CCl4) was used to observe the effects of Zhizi Baipi soup and its disassembled prescription by oral adminstration, the bile volume was determinied by common bile duct drainage.
  
  
  RESULTS
  Zhizi Baipi soup and each treatment group with gardenia could significantly inhibit the increased serum ATL and AST activities, reduce liver MDA level, and significantly promote the bile flow and bilirubin in bile in normal rats.
  
  
  CONCLUSIONS
  Zhizi Baipi soup has effects on protecting liver and increasing bile secretion, its monarch drug, gardenia plays an important role in the decoction, the effect of eliminating dampness and heat are mainly ascribed to the synergic effect of gardenia and phellodendron.
authors.affiliation: The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China. 55441626@qq.com
authors.forename: Xu
authors.initials: X
authors.lastname: Xiao
authors.affiliation: The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
authors.forename: Ji-Xiao
authors.initials: JX
authors.lastname: Zhu
authors.affiliation: The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
authors.forename: Guang-Ming
authors.initials: GM
authors.lastname: Luo
authors.affiliation: The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.affiliation: The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
authors.forename: Yu-Ye
authors.initials: YY
authors.lastname: Zhu
authors.affiliation: The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
authors.forename: Jin-Xiang
authors.initials: JX
authors.lastname: Zeng
authors.affiliation: The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
authors.forename: Xiao-Yun
authors.initials: XY
authors.lastname: Wang
authors.affiliation: The Chinese Medicine Germplasm Resource Engineering Technology Research Center of Jiangxi Province, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Wu
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001646:Bile / Q000378:metabolism; D001663:Bilirubin / Q000378:metabolism; D002251:Carbon Tetrachloride; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D005704:Gallbladder / Q000187:drug effects* / Q000378:metabolism; D032062:Gardenia / Q000737:chemistry; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027821:Rutaceae / Q000737:chemistry
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin