title: Challenges of managing pain in constipation-predominant IBS: clinical perspectives on antinociceptive actions of linaclotide.
authors.forename: William L
authors.initials: WL
authors.lastname: Hasler
authors.forename: Chung
authors.initials: C
authors.lastname: Owyang
mesh_terms: D015746:Abdominal Pain / Q000517:prevention & control*; D000818:Animals; D003106:Colon / Q000294:innervation*; D006152:Cyclic GMP / Q000502:physiology*; D005260:Female; D006162:Guanylate Cyclase / Q000502:physiology*; D006801:Humans; D008297:Male; D009619:Nociceptors / Q000187:drug effects*; D010455:Peptides / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D010455:Peptides; D006162:Guanylate Cyclase; D006152:Cyclic GMP; C523483:linaclotide