title: Lipoprotein lipase gene HindIII polymorphism and risk of myocardial infarction in South Indian population.
abstract: BACKGROUND
  Studies have reported an association between lipoprotein lipase (LPL) gene and myocardial infarction in some populations. Therefore, the present study aimed to investigate the association of the HindIII polymorphism of the (LPL) gene with myocardial infarction and to explore its potential role in susceptibility in a South Indian population.
  
  
  METHODS
  We included a total of 412 subjects (202 myocardial infarction patients and 210 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the LPL gene HindIII polymorphism was determined by polymerase chain reaction.
  
  
  RESULTS
  Comparison of the lipid profiles between patients and controls showed that patients had statistically high significant values (p = 0.0001). The H(+) H(+) genotype of the LPL gene is associated with myocardial infarction. H(+) H(+) vs. H(-) H(-) was χ2 = 19.4, OR 3.1, CI 95% 1.8-5.2, p < 0.0001.
  
  
  CONCLUSIONS
  Our study strongly suggests that the LPL gene HindIII Hþ Hþ genotype is an independent risk factor for first MI.
authors.affiliation: Department of Genetics, Osmania University, Hyderabad 500013, A.P., India.
authors.forename: Parthasaradhi Reddy
authors.initials: PR
authors.lastname: Tanguturi
authors.affiliation: Department of Cell and Molecular Biology, Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad 500013, A.P., India.
authors.forename: Bhoomireddy
authors.initials: B
authors.lastname: Pullareddy
authors.affiliation: Department of Animal Sciences, University of Hyderabad, Hyderabad 50013, A.P., India.
authors.forename: B S
authors.initials: BS
authors.lastname: Rama Krishna
authors.affiliation: Department of Genetics, Osmania University, Hyderabad 500013, A.P., India. Electronic address: dwarkanath49@yahoo.co.in.
authors.forename: Dwarkanath K
authors.initials: DK
authors.lastname: Murthy
mesh_terms: D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D008071:Lipoprotein Lipase / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D017678:Sex Distribution; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000235:genetics*; D015996:Survival Rate
chemical_list: C090528:DNA modification methylase HindIII; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific); D008071:Lipoprotein Lipase
keywords: Coronary artery disease; HindIII polymorphism; Lipoprotein lipase; Myocardial infarction; South Indian population