title: Swim everyday to keep dementia away.
abstract: A sound mind resides in a sound body. Many individuals with an active lifestyle show sharp mental skills at an advanced age. Regular exercise has been shown to exert numerous beneficial effects on brawn as well as brain. The present study was undertaken to evaluate the influence of swimming on memory of rodents. A specially designed hexagonal water maze was used for the swimming exposures of animals. The learning and memory parameters were measured using exteroceptive behavioral models such as Elevated plus-maze, Hebb-Williams maze and Passive avoidance apparatus. The rodents (rats and mice) were divided into twelve groups. The swimming exposure to the rodents was for 10- minute period during each session and there were two swimming exposures on each day. Rats and mice were subjected to swimming for -15 and -30 consecutive days. Control group animals were not subjected to swimming during above period. The learning index and memory score of all the animals was recorded on 1(st), 2(nd), 15(th), 16(th), 30(th) and 31(st) day employing above exteroceptive models. It was observed that rodents that underwent swimming regularly for 30- days showed sharp memories, when tested on above behavioral models whereas, control group animals showed decline in memory scores. Those animals, which underwent swimming for 15- days only showed good memory on 16(th) day, which however, declined after 30-days. These results emphasize the role of regular physical exercise particularly swimming in the maintenance and promotion of brain functions. The underlying physiological mechanism for improvement of memory appears to be the result of enhanced neurogenesis. Key PointsMaintaining brain health throughout life is an important public health goal.Our results point out that integration of exercise schedule into the life style of Alzheimer patients is advantageous and worthwhile.Exercising regularly as you get older may not only keep your body in shape, but your brains as well.
authors.affiliation: Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University , Hisar (Haryana), India.
authors.forename: Milind
authors.initials: M
authors.lastname: Parle
authors.affiliation: Pharmacology Division, Department of Pharmaceutical Sciences, Guru Jambheshwar University , Hisar (Haryana), India.
authors.forename: Mani
authors.initials: M
authors.lastname: Vasudevan
authors.affiliation: Department of Pharmaceutical Sciences & Drug Research, Punjabi University , Patiala (Punjab), India.
authors.forename: Nirmal
authors.initials: N
authors.lastname: Singh
keywords: Dementia; exercise; neurogenesis; swimming