title: Evaluation of new treatment for incipient enamel demineralization using 45S5 bioglass.
abstract: Bioglass 45S5 is a silica-based bioactive glass capable of depositing a layer of hydroxyl carbonate apatite on the surface of the glass when immersed in body fluids. The present paper studies a new technique for treating early human dental enamel caries lesions by using a paste composed of 45S5 bioglass and phosphoric acid. Artificial caries lesions were induced in enamel flat surfaces by means of a decalcification solution. All specimens were exposed to a brushing-abrasion challenge to test the durability of any newly formed layer resulting from the application of 45S5 bioglass paste. The specimens treated with bioglass paste showed complete coverage with a layer of brushite crystals. The brushing-abrasion challenge did not statistically affect the percentage of enamel coverage with the crystalline layer formed by the application of bioglass (p<0.05). These crystals were converted to hydroxyapatite crystals when stored in artificial saliva for 14 days. The current technique suggests the possibility of restoring incipient enamel erosive lesion with an abrasion durable layer of hydroxyapatite crystals.
authors.affiliation: Operative Dentistry Department, Faculty of Dentistry, King AbdulAziz University, Jeddah, Saudia Arabia; Conservative Dentistry Department, Faculty of Dentistry, Alexandria University, Egypt; Japan Society for the Promotion of Science, Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address: drahmedbakry@gmail.com.
authors.forename: A S
authors.initials: AS
authors.lastname: Bakry
authors.affiliation: Oral Biomaterials Engineering, Department of Oral Materials Sciences and Technology, Course of Oral Health Engineering, School of Health Care Sciences, Faculty of Dentistry, Tokyo Medical and Dental University, 1-5-45Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Otsuki
authors.affiliation: Cariology and Operative Dentistry, Department of Restorative Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan; Global Center of Excellence Program, ICTB at Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Tagami
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry; D002516:Ceramics / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible; D003731:Dental Caries / Q000628:therapy; D003743:Dental Enamel / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry; D005898:Glass; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008963:Molar; D012464:Saliva, Artificial; D013499:Surface Properties; D013997:Time Factors; D017001:Tooth Demineralization / Q000628:therapy*; D014961:X-Ray Diffraction
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D012464:Saliva, Artificial; C425330:bioactive glass 45S5; D017886:Durapatite; C494366:calcium phosphate, dibasic, dihydrate
keywords: Bioactive glass; Bioactivity; Brushite; Calcium phosphate coating