title: Homoegonol attenuates the asthmatic responses induced by ovalbumin challenge.
abstract: Homoegonol is a lignan derived from styraxlignolide A, which was isolated from Styrax japonica, a medicinal plant widely used for treatment of inflammatory diseases in Korea. We investigated the efficacy of homoegonol for the treatment of allergic asthma using an ovalbumin (OVA)-induced murine asthma model. The mice were sensitized through intraperitoneal injections of OVA on days 0 and 14. On days 21, 22 and 23 after the initial OVA sensitization, the mice were received OVA airway challenge. Homoegonol was administered by oral gavage at a dose of 30 mg/kg 1 h prior to the OVA challenge. The homoegonol-treated mice exhibited reduced inflammatory cell counts and Th2 cytokines in BALF, AHR, and IgE in the serum compared with the OVA-sensitized/challenged mice. The histological analysis of the lung tissue revealed that the administration of homoegonol attenuated the airway inflammation and the mucus overproduction in airway epithelial lesions induced by OVA through a reduction in expression of inducible nitric oxide synthase and matrix metalloproteinase-9. These findings indicate that homoegonol effectively suppresses the asthmatic responses induced by OVA challenge and suggests that homoegonol exhibits potential as therapeutic drug for allergic asthma.
authors.affiliation: Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang-eup, Cheongwon-gun, Chungbuk, 363-883, Republic of Korea, dvmmk79@gmail.com.
authors.forename: In-Sik
authors.initials: IS
authors.lastname: Shin
authors.forename: Kyung-Seop
authors.initials: KS
authors.lastname: Ahn
authors.forename: Na-Rae
authors.initials: NR
authors.lastname: Shin
authors.forename: Chan-Mi
authors.initials: CM
authors.lastname: Jeon
authors.forename: Ok-Kyoung
authors.initials: OK
authors.lastname: Kwon
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
authors.forename: Kyeong
authors.initials: K
authors.lastname: Lee
authors.forename: Sei-Ryang
authors.initials: SR
authors.lastname: Oh
mesh_terms: D000284:Administration, Oral; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D000840:Anisoles / Q000008:administration & dosage / Q000627:therapeutic use*; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D001572:Benzofurans / Q000008:administration & dosage / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D016207:Cytokines / Q000032:analysis / Q000378:metabolism; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D007073:Immunoglobulin E / Q000032:analysis; D017705:Lignans / Q000008:administration & dosage / Q000627:therapeutic use*; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D020780:Matrix Metalloproteinase 9 / Q000737:chemistry / Q000378:metabolism; D008807:Mice, Inbred BALB C; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors / Q000378:metabolism; D010047:Ovalbumin; D020545:Respiratory Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D013047:Specific Pathogen-Free Organisms
chemical_list: D000840:Anisoles; D018926:Anti-Allergic Agents; D018927:Anti-Asthmatic Agents; D001572:Benzofurans; D016207:Cytokines; D017705:Lignans; C000597557:homoegonol; D007073:Immunoglobulin E; D010047:Ovalbumin; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D020780:Matrix Metalloproteinase 9; C501830:Mmp9 protein, mouse