title: Hemichorea in a thymoma patient without anti-CRMP-5 antibody.
abstract: We reported a 72-year-old man with thymoma who presented with hemichorea. Although his brain CT and MRI revealed no abnormality, regional cerebral blood flow changes, identified by single photon emission computed tomography, suggested that the mechanism underlying the chorea seemed to be a dysfunction of the subthalamic nucleus and pallidum. His hemichorea was completely resolved after thymectomy. Absence of serum anti-neural autoantibodies, including small-cell lung carcinoma-related chorea anti-CRMP-5 antibody, suggests that mechanisms different from cross-talk neural-targeted tumor immune response can be responsible for the thymoma-associated paraneoplastic chorea.
authors.affiliation: Department of Neurology, Hiratsuka Kyosai Hospital, 9-11, Oiwake, Hiratsuka, Japan, nakae-y@kkr.hiratsuka.kanagawa.jp.
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Nakae
authors.forename: Shingo
authors.initials: S
authors.lastname: Ikeda
authors.forename: Ryoo
authors.initials: R
authors.lastname: Yamamoto
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tanaka
authors.forename: Ken
authors.initials: K
authors.lastname: Johkura
mesh_terms: D000368:Aged; D000906:Antibodies; D002819:Chorea / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D006867:Hydrolases; D008297:Male; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins / Q000276:immunology; D013945:Thymoma / Q000150:complications / Q000175:diagnosis*; D013953:Thymus Neoplasms / Q000150:complications / Q000175:diagnosis*
chemical_list: D000906:Antibodies; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; C415087:DPYSL5 protein, human; D006867:Hydrolases