title: H1N1 influenza A virus Related Pneumonia and Respiratory Failure.
abstract: Influenza viruses are common respiratory pathogens in humans and can cause serious infection that leads to the development of pneumonia. In this study, the clinical and laboratory features of 36 patients from Turkey who are hospitalized in intensive care unit due to pandemic influenza A (H1N1) associated pneumonia and respiratory failure were retrospectively evaluated. The most common symptoms were cough and fever. Consolidation (36.1 %) and interstitial changes (30.6 %) were the most frequently identified findings on chest radiographs at the time of admission. Six of the patients (16.7 %) died. Mortality occurred in 3 of 13 patients (23.1 %) with underlying disease, whilst it occurred in only 3 of 23 patients (13 %) who were previously healthy. Mortality was found to be significantly associated only with an elevated lactate dehydrogenase level. A significant relationship was determined only between the presence of lymphopenia and acute respiratory distress syndrome and the need for intensive care treatment. The average time elapsed from the onset of the symptoms until admission was 8.67 ± 2.87 days for the patients died, and 6.0 ± 3.8 days for the patients survived.
authors.affiliation: Department of Pediatrics, Duzce University Medical Faculty, Duzce, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Okur
authors.affiliation: Department of Pediatrics, Women's and Children's Hospital, Van, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Erbey
authors.affiliation: Department of Infectious Diseases, Women's and Children's Hospital, Van, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yazicioglu
authors.affiliation: Department of Infectious Diseases, Education and Research Hospital, Van, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Celik
authors.affiliation: Department of Anesthesiology, Education and Research Hospital, Van, Turkey.
authors.forename: Baris
authors.initials: B
authors.lastname: Tukenmez
authors.affiliation: Department of Infectious Diseases, Education and Research Hospital, Van, Turkey.
authors.forename: Mahmut
authors.initials: M
authors.lastname: Sunnetcioglu
authors.affiliation: Department of Chest Diseases, Education and Research Hospital, Van, Turkey.
authors.forename: Mithat
authors.initials: M
authors.lastname: Gassaloglu
authors.affiliation: Department of Pediatrics, Women's and Children's Hospital, Van, Turkey.
authors.forename: Mehmet Nuri
authors.initials: MN
authors.lastname: Acar
authors.affiliation: Department of Pediatrics, Women's and Children's Hospital, Van, Turkey.
authors.forename: Avni
authors.initials: A
authors.lastname: Kaya
keywords: H1N1; Pneumonia; Respiratory failure; Swine influenza virus