title: Efficient phosphodiester cleaving nanozymes resulting from multivalency and local medium polarity control.
abstract: The self-organization of Zn(II) complexes on the surface of 1.6-nm diameter gold nanoparticles (nanozymes) allows the spontaneous formation of multiple bimetallic catalytic sites capable to promote the cleavage of a RNA model substrate. We show that by tuning the structure of the nanoparticle-coating monolayer, it is possible to decrease the polarity of the reaction site, and this in turn generates remarkable increments of the cleavage efficiency.
authors.affiliation: Department of Chemical Sciences, University of Padova , via Marzolo 1, 35131 Padova, Italy.
authors.forename: Marta
authors.initials: M
authors.lastname: Diez-Castellnou
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Mancin
authors.forename: Paolo
authors.initials: P
authors.lastname: Scrimin
mesh_terms: D002384:Catalysis; D006046:Gold / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010755:Organophosphates / Q000737:chemistry*; D010316:Particle Size; D013499:Surface Properties; D013816:Thermodynamics; D015032:Zinc / Q000737:chemistry*
chemical_list: C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D009942:Organometallic Compounds; D010755:Organophosphates; D006046:Gold; D015032:Zinc