title: Bilateral subependymal heterotopia, ventriculomegaly and cerebellar asymmetry: fetal MRI findings of a rare association of brain anomalies.
abstract: Subependymal heterotopia (SEH) is a neuronal migration disorder characterized by nodules of gray matter along the lateral ventricular walls and often associated with other brain malformations. We present two cases of SEH associated with ventriculomegaly and cerebellar abnormalities diagnosed by fetal magnetic resonance imaging (MRI) at 20 and 23 weeks' gestation respectively. Fetal MRI findings of this association of abnormalities have never been reported in literature. This report emphasizes the role of fetal MRI in recognition of subependymal heterotopia and other associated brain anomalies at early age of gestation along with its importance for a more targeted counseling and management strategies.
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Manganaro
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Saldari
authors.affiliation: Department of Radiological, Oncological and Anatomopathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Bernardo
authors.affiliation: Department of Obstetrics, Gynecology and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
authors.forename: Camilla
authors.initials: C
authors.lastname: Aliberti
authors.affiliation: Surgical Pathology Unit, San Camillo Forlanini Hospital, Rome, Italy.
authors.forename: Evelina
authors.initials: E
authors.lastname: Silvestri
mesh_terms: D000328:Adult; D001921:Brain / Q000002:abnormalities*; D001927:Brain Diseases / Q000175:diagnosis*; D002531:Cerebellum / Q000002:abnormalities; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000379:methods; D054081:Malformations of Cortical Development, Group II / Q000175:diagnosis*; D011296:Prenatal Diagnosis / Q000379:methods
keywords: Cerebellar abnormalities; Fetal MRI; Subependymal heterotopia; Ventriculomegaly