title: Rosmarinic acid ameliorates PTSD-like symptoms in a rat model and promotes cell proliferation in the hippocampus.
abstract: Rosmarinic acid (RA) is an important component of Chinese herbal medicine treatments and has been demonstrated to exert therapeutic effects in mood disorders. The present study was designed to assess the effects of RA on post-traumatic stress disorder (PTSD)-like symptoms, hippocampal cell proliferation and phosphorylation extracellular regulated protein kinases (pERK1/2) expression. We found that administration of RA (10mg/kg) alleviated PTSD-like symptoms in rats exposed to an enhanced single prolonged stress (ESPS) paradigm and restored hippocampal proliferation and pERK1/2 expression. Interestingly, the effects of RA were inhibited by the blockage of the ERK signaling. These data support the use of RA for treating PTSD and indicate that the ERK1/2 signaling cascade may play a critical role in the therapeutic efficacy of RA in treating such conditions.
authors.affiliation: Department of Psychosomatic Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China; Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Nie
authors.affiliation: Department of Psychosomatic Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China; Department of Toxicology, School of Public Health, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Zhengwu
authors.initials: Z
authors.lastname: Peng
authors.affiliation: Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Lao
authors.affiliation: Department of Psychosomatic Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Huaning
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Psychosomatic Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Yihuan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Zongping
authors.initials: Z
authors.lastname: Fang
authors.affiliation: Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Wugang
authors.initials: W
authors.lastname: Hou
authors.affiliation: Institute of Neuroscience, The Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Gao
authors.affiliation: Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. Electronic address: mzkxlz@126.com.
authors.forename: Lize
authors.initials: L
authors.lastname: Xiong
authors.affiliation: Department of Psychosomatic Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710032, China. Electronic address: tanqingr@fmmu.edu.cn.
authors.forename: Qingrong
authors.initials: Q
authors.lastname: Tan
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001973:Bromodeoxyuridine / Q000378:metabolism; D002070:Butadienes / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002934:Cinnamates / Q000627:therapeutic use*; D053630:Depsides / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D020935:MAP Kinase Signaling System / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D058953:Neural Stem Cells / Q000187:drug effects; D009570:Nitriles / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy* / Q000473:pathology*; D000097123:Rosmarinic Acid
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001973:Bromodeoxyuridine; D002070:Butadienes; D002934:Cinnamates; D053630:Depsides; D004791:Enzyme Inhibitors; D009570:Nitriles; D000097123:Rosmarinic Acid; C113580:U 0126
keywords: Hippocampus; Post-traumatic stress disorder; Proliferation; Rosmarinic acid