title: Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection.
abstract: Pregnant women bear the greatest burden of malaria-human immunodeficiency virus co-infection. Previous studies suggest that interaction with antiretroviral drugs may compromise antimalarial pharmacokinetics and treatment outcomes. We conducted a preliminary clinical study to assess quinine pharmacokinetics in Malian pregnant women with acute malaria who reported taking nevirapine-based antiretroviral therapy. Of seven women, six had stable concentrations of nevirapine in the plasma and one had none. Quinine concentrations were lower, and its metabolite 3-hydroxyquinine higher, in the six women with nevirapine than in the one without, and quinine concentrations were below the recommended therapeutic range in 50% of the women. This preliminary observation warrants further research to understand the impact of long-term antiretroviral therapy on the treatment of acute malaria.
authors.forename: Kassoum
authors.initials: K
authors.lastname: Kayentao
authors.forename: Etienne A
authors.initials: EA
authors.lastname: Guirou
authors.forename: Ogobara K
authors.initials: OK
authors.lastname: Doumbo
authors.forename: Meera
authors.initials: M
authors.lastname: Venkatesan
authors.forename: Christopher V
authors.initials: CV
authors.lastname: Plowe
authors.forename: Teresa L
authors.initials: TL
authors.lastname: Parsons
authors.forename: Craig W
authors.initials: CW
authors.lastname: Hendrix
authors.forename: Myaing M
authors.initials: MM
authors.lastname: Nyunt
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000097:blood / Q000627:therapeutic use*; D000962:Antimalarials / Q000493:pharmacokinetics* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D060085:Coinfection; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D016778:Malaria, Falciparum / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D019829:Nevirapine / Q000097:blood / Q000627:therapeutic use*; D059208:Parasite Load; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000378:metabolism; D011446:Prospective Studies; D011802:Quinidine / Q000031:analogs & derivatives / Q000097:blood / Q000493:pharmacokinetics; D011803:Quinine / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D018119:Stavudine / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D000962:Antimalarials; C013569:3-hydroxyquinidine; D019259:Lamivudine; D015215:Zidovudine; D019829:Nevirapine; D011803:Quinine; D018119:Stavudine; D011802:Quinidine