title: Pestalafuranones F-J, five new furanone analogues from the endophytic fungus Nigrospora sp. BM-2.
abstract: Five new 2(5H)-furanone-type derivatives, pestalafuranones F-J (compounds 3-7), together with two known compounds, pestalafuranones A (1) and B (2), were isolated from the ethyl acetate extract from the fermentation broth of the endophytic fungus Nigrospora sp. BM-2 in a hypersaline medium. The structures of these metabolites were elucidated by EIMS, HREIMS and NMR spectroscopic data. Compounds 1-7 exhibited no cytotoxic activities against the MDA-MB-231 and Caski cancer cell lines.
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China.
authors.forename: Hongqi
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China. d.zhangshuang@gmail.com.
authors.forename: Zhangshuang
authors.initials: Z
authors.lastname: Deng
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Tu
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China.
authors.forename: Junzhi
authors.initials: J
authors.lastname: Wang
authors.affiliation: Hubei Key Laboratory of Natural Products Research and Development, College of Chemistry and Life Science, China Three Gorges University, Yichang 443002, China. kzou@ctgu.edu.cn.
authors.forename: Kun
authors.initials: K
authors.lastname: Zou
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003460:Crystallization; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation
chemical_list: D000970:Antineoplastic Agents; D005663:Furans