title: A Behavioral Manipulation Engages Right Frontal Cortex During Aphasia Therapy.
abstract: Background An aphasia treatment was designed to shift laterality from the left to right lateral frontal lobe during word production by initiating word-finding trials with complex left-hand movements. Previous findings indicated successful relateralization. Objective The current study was designed to ascertain whether the shift was attributable to the left-hand movement. Methods Using stratified random sampling, 14 subjects were equally divided between Intention (IT) and Control (CT) treatments. CT was identical to IT, except with no left-hand movements. Both treatments trained picture naming (phases 1 and 2) and category-member generation (phase 3), each phase lasting 10 sessions. Functional magnetic resonance imaging of category member generation occurred at pretreatment, posttreatment, and 3-month follow-up. Results IT shifted lateral frontal activity rightward compared with pretreatment both at posttreatment (t = -2.602, df = 6, P < .05) and 3-month follow-up (t = -2.332, df = 5, P < .05), but CT did not. IT and CT yielded similar changes for all picture-naming and category probes. However, IT patients showed gains for untrained category (t = 3.33, df = 6, P < .01) and picture-naming probes (t = 3.77, df = 5, P < .01), but CT patients did not. Conclusions The rightward shift in lateral frontal activity for IT was because of the left-hand movements. IT evoked greater generalization than CT.
authors.affiliation: The University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Benjamin
authors.affiliation: Atlanta VA RR&D Center of Excellence, Decatur, GA, USA.
authors.forename: Stephen
authors.initials: S
authors.lastname: Towler
authors.affiliation: University of Florida, Gainesville, FL, USA.
authors.forename: Amanda
authors.initials: A
authors.lastname: Garcia
authors.affiliation: University of Florida, Gainesville, FL, USA.
authors.forename: Hyejin
authors.initials: H
authors.lastname: Park
authors.affiliation: University of California, San Francisco, CA, USA.
authors.forename: Atchar
authors.initials: A
authors.lastname: Sudhyadhom
authors.affiliation: Ohio State University, Columbus, OH, USA.
authors.forename: Stacy
authors.initials: S
authors.lastname: Harnish
authors.affiliation: Atlanta VA RR&D Center of Excellence, Decatur, GA, USA Emory University, Atlanta, GA, USA.
authors.forename: Keith M
authors.initials: KM
authors.lastname: McGregor
authors.affiliation: University of California, San Diego, CA, USA.
authors.forename: Zvinka
authors.initials: Z
authors.lastname: Zlatar
authors.affiliation: University of Florida, Gainesville, FL, USA.
authors.forename: Jamie J
authors.initials: JJ
authors.lastname: Reilly
authors.affiliation: University of Florida, Gainesville, FL, USA Gainesville VA RR&D Center of Excellence, Gainesville, FL, USA.
authors.forename: John C
authors.initials: JC
authors.lastname: Rosenbek
authors.affiliation: University of Florida, Gainesville, FL, USA Gainesville VA RR&D Center of Excellence, Gainesville, FL, USA.
authors.forename: Leslie J
authors.initials: LJ
authors.lastname: Gonzalez Rothi
authors.affiliation: Atlanta VA RR&D Center of Excellence, Decatur, GA, USA Emory University, Atlanta, GA, USA Georgia State University, Atlanta, GA, USA bruce.crosson@emory.edu.
authors.forename: Bruce
authors.initials: B
authors.lastname: Crosson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001037:Aphasia / Q000534:rehabilitation*; D001931:Brain Mapping / Q000379:methods*; D003210:Concept Formation / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D005793:Generalization, Psychological / Q000502:physiology; D006225:Hand; D006801:Humans; D007808:Language Therapy / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D016896:Treatment Outcome
keywords: aphasia; fMRI; magnetic resonance imaging; neuronal plasticity; rehabilitation; rehabilitation of speech and language disorders