title: [Sudden death occurring after anti-Hu associated paraneoplastic cerebellar degeneration and dysautonomia revealing a small cell lung carcinoma].
abstract: BACKGROUND
  Paraneoplastic syndromes are a rare cancer complication with a frequent subacute evolution.
  
  
  METHODS
  A 62-year-old man was admitted presenting with a cerebellar syndrome and orthostatic hypotension with dysautonomia. Anti-Hu antibody research was positive. A subcarinal adenopathy biopsy found out a small cell lung carcinoma. Despite a treatment with immunoglobulin and chemotherapy, the patient died suddenly, after a raise of dysautonomia symptoms.
  
  
  CONCLUSIONS
  Sudden death observations represent exceptional complications of paraneoplastic syndrome. They might be secondary to arrhythmias, ictal asystol or laryngospasm. Systematic research of paroxystic heart arrhythmias with holter-ECG in paraneoplastic syndrome may prevent sudden deaths.
authors.affiliation: Service de médecine interne, université Paris-13, hôpital Jean-Verdier, AP-HP, avenue du 14-Juillet, 93140 Bondy, France.
authors.forename: A
authors.initials: A
authors.lastname: Mirouse
authors.affiliation: Service de médecine interne, université Paris-13, hôpital Jean-Verdier, AP-HP, avenue du 14-Juillet, 93140 Bondy, France.
authors.forename: D
authors.initials: D
authors.lastname: Gobert
authors.affiliation: Service de médecine interne, université Paris-13, hôpital Jean-Verdier, AP-HP, avenue du 14-Juillet, 93140 Bondy, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Chamouard
authors.affiliation: Service de médecine interne, université Paris-13, hôpital Jean-Verdier, AP-HP, avenue du 14-Juillet, 93140 Bondy, France.
authors.forename: L
authors.initials: L
authors.lastname: Iordache
authors.affiliation: Service de médecine interne, université Paris-13, hôpital Jean-Verdier, AP-HP, avenue du 14-Juillet, 93140 Bondy, France.
authors.forename: A
authors.initials: A
authors.lastname: Mekinian
authors.affiliation: Service de médecine interne, université Paris-13, hôpital Jean-Verdier, AP-HP, avenue du 14-Juillet, 93140 Bondy, France. Electronic address: olivier.fain@jvr.aphp.fr.
authors.forename: O
authors.initials: O
authors.lastname: Fain
mesh_terms: D000906:Antibodies / Q000097:blood; D003645:Death, Sudden / Q000209:etiology*; D051959:ELAV Proteins / Q000276:immunology*; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D020362:Paraneoplastic Cerebellar Degeneration / Q000209:etiology*; D020361:Paraneoplastic Syndromes, Nervous System / Q000209:etiology*; D012791:Shy-Drager Syndrome / Q000209:etiology*; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis*
chemical_list: D000906:Antibodies; D051959:ELAV Proteins
keywords: Arrhytmias; Arythmies; Autonomic nervous system diseases; Dysautonomie; Dégénérescence cérébelleuse subaiguë; Mort subite; Nervous system; Paraneoplastic cerebellar degeneration; Paraneoplastic syndromes; Sudden death; Syndromes neurologiques paranéoplasiques