title: Treatment of ovarian anaplastic ependymoma by an aromatase inhibitor.
abstract: BACKGROUND
  Histopathologic diagnosis and treatment of ovarian anaplastic ependymoma are challenging.
  
  
  METHODS
  A 61-year-old-woman presented with a 10-cm right adnexal tumor associated with peritoneal carcinomatosis extending to the right diaphragm and liver surface. After initial diagnosis of a papillary serous carcinoma, we performed extensive but nonoptimal cytoreductive surgery including hysterectomy with bilateral oophorectomy. Histology revealed some axially arranged cells with a prominent fibrillary cytoplasm, suggesting an ependymoma. Diagnosis was confirmed by immunophenotype showing strong positivity to glial fibrillary acidic protein. Given the strong tumoral expression of estrogen and progesterone receptors, an aromatase inhibitor was initiated. One year later, computed tomography scan showed stability of the residual peritoneal nodules.
  
  
  CONCLUSIONS
  Aromatase inhibitor treatment could be effective in cases of extraaxial ependymoma with prominent estrogen receptor expression.
authors.affiliation: Clinique Geoffroy Saint Hilaire, Gynecology Department, and the Departments of Radiology and Medical Oncology, Université Paris Descartes, Faculté de Médecine, AP-HP, Groupe Hospitalier Cochin-Hôtel Dieu, Paris, France; and the University of Granada Medical School, Department of Pathology, Granada, Spain. Pascal Rousset is currently affiliated with the Department of Radiology, Lyon Sud Hospital, Pierre Bénite, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Deval
authors.forename: Pascal
authors.initials: P
authors.lastname: Rousset
authors.forename: Camille
authors.initials: C
authors.lastname: Bigenwald
authors.forename: Francisco F
authors.initials: FF
authors.lastname: Nogales
authors.forename: Jerome
authors.initials: J
authors.lastname: Alexandre
mesh_terms: D000077384:Anastrozole; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D004806:Ependymoma / Q000175:diagnosis / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009570:Nitriles / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000201:enzymology; D014230:Triazoles / Q000627:therapeutic use*
chemical_list: D047072:Aromatase Inhibitors; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole