title: [Season fluctuations of carbamazepine and valproate concentration in patients with epilepsy].
abstract: We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49). The seasonal distribution of number and severity of seizures assessed with the NHS3 scale in dependence of Cmin and Cmax content of antiepileptic drugs carbamazepine and valproates in the serum of patients was estimated. There was a significant increase in the number of seizures and their severity in the cycle spring>autumn>summer>winter. The serum content of carbamazepine and valproates was significantly lower in spring compared to autumn.
authors.forename: G N
authors.initials: GN
authors.lastname: Avakian
authors.forename: O M
authors.initials: OM
authors.lastname: Oleĭnikova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Lagutin
authors.forename: E A
authors.initials: EA
authors.lastname: Khromykh
authors.forename: M A
authors.initials: MA
authors.lastname: Bogomazova
authors.forename: A B
authors.initials: AB
authors.lastname: Delger
authors.forename: G G
authors.initials: GG
authors.lastname: Avakian
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D002220:Carbamazepine / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012621:Seasons; D014635:Valproic Acid / Q000097:blood* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid