title: Role for Mycobacterium tuberculosis membrane vesicles in iron acquisition.
abstract: Mycobacterium tuberculosis releases membrane vesicles packed with molecules that can modulate the immune response. Because environmental conditions often influence the production and content of bacterial vesicles, this study examined M. tuberculosis microvesicles released under iron limitation, a common condition faced by pathogens inside the host. The findings indicate that M. tuberculosis increases microvesicle production in response to iron restriction and that these microvesicles contain mycobactin, which can serve as an iron donor and supports replication of iron-starved mycobacteria. Consequently, the results revealed a role of microvesicles in iron acquisition in M. tuberculosis, which can be critical for survival in the host.
authors.affiliation: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
authors.forename: Rafael
authors.initials: R
authors.lastname: Prados-Rosales
authors.forename: Brian C
authors.initials: BC
authors.lastname: Weinrick
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Piqué
authors.forename: William R
authors.initials: WR
authors.lastname: Jacobs
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: G Marcela
authors.initials: GM
authors.lastname: Rodriguez
mesh_terms: D055354:Exosomes / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D010080:Oxazoles / Q000378:metabolism; D022161:Transport Vesicles / Q000378:metabolism*
chemical_list: D010080:Oxazoles; C018608:mycobactins; D007501:Iron