title: Alterations in Circulating Adhesion Molecules in Acute Myocardial Infarction before and after Thrombolysis with Streptokinase.
abstract: BACKGROUND
  The role of adhesion molecules in the development and progression of coronary atherosclerosis is inevitable. It is not clear yet whether these molecules increase or decrease in level after thrombolytic therapy. This study was designed to compare concentrations of soluble forms of adhesion molecules in patients with acute myocardial infarction before and after reperfusion by thrombolysis with streptokinase (SK).
  
  
  METHODS
  In this study, in 40 patients with acute myocardial infarction who were admitted in our Emergency Department undergoing thrombolysis with SK, plasma concentrations of six adhesion molecules [soluble L-selectin, P-selectin, E-selectin, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet endothelial cell adhesion molecule-1 (PECAM-1)] were measured by enzyme linked immunosorbent assay (ELISA), before and 3 hours after intervention.
  
  
  RESULTS
  While soluble E-selectin and PECAM-1 concentrations did not differ within the 3 hours after interventions (P&gt; 0.05), the level of P-selectin, L-selectin, ICAM-1, VCAM-1 were significantly reduced after thrombolysis with SK (P&lt; 0.05).
  
  
  CONCLUSIONS
  Adhesion molecules which mediate the interactions in leukocyte endothelium vary in levels after reperfusion with SK. It was shown that 4 out of 6 adhesion molecules significantly reduced after thrombolysis with SK.
authors.affiliation: Department of Emergency, Rasul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Saidi
authors.affiliation: Department of Emergency, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Vakilian
authors.affiliation: Department of Emergency, Rasul-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Gholam Hosein
authors.initials: GH
authors.lastname: Noori
authors.affiliation: Department of Emergency, 7 Tir Martyrs Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Hamed-Basir
authors.initials: HB
authors.lastname: Ghafouri
authors.affiliation: Department of Emergency, 7 Tir Martyrs Hospital, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Niloofar
authors.initials: N
authors.lastname: Abazarian
keywords: Adhesion Molecules; Myocardial Infarction; Streptokinase