title: [Treatment of rheumatoid arthritis arthralgia by xiaoyan zhitong paste: a clinical observation].
abstract: OBJECTIVE
  To formulate a comprehensive treatment program for rheumatoid arthritis arthralgia by clinical observing the efficacy of Xiaoyan Zhitong Paste (XZP).
  
  
  METHODS
  Adopted was stratified, block randomized, double-blinded, placebo parallel controlled method. Subjects were assigned to the treatment group and the placebo group. Those in the treatment group were treated by external application of XZP, one to two pastes each time, covering the painful area, exchange once per 24 h, with one-day interval during a 7-day consecutive medication, two 7-days of treatment consisting of one therapeutic course. XZP placebos were applied for those in the placebo group in the same medication way. Joint pain and VAS were taken as main indices for observing the clinical efficacy of XZP.
  
  
  RESULTS
  The improvement of the analgesic effect and the Chinese medical syndrome efficacy of XZP were superior to that of the placebo.
  
  
  CONCLUSIONS
  XZP showed obvious effect in treating rheumatoid arthritis arthralgia with no obvious adverse reaction.
authors.affiliation: Department of Rheumatology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Qiu-Ai
authors.initials: QA
authors.lastname: Kou
authors.affiliation: Department of Rheumatology, Baoding Dongfang Chinese Pharmacy Co., Ltd., Hebei 071000, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Department of Rheumatology, Jinzhong Municipal Hospital of Traditional Chinese Medicine, Shanxi 030600, China.
authors.forename: Jin-Yuan
authors.initials: JY
authors.lastname: Yao
authors.affiliation: Department of Rheumatology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China.
authors.forename: Yi-Jun
authors.initials: YJ
authors.lastname: Wang
authors.affiliation: Department of Rheumatology, Second Affiliated Hospital, Shanxi College of Traditional Chinese Medicine, Taiyuan 030053, China.
authors.forename: Wen-Hui
authors.initials: WH
authors.lastname: Ma
authors.affiliation: Department of Rheumatology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Zhou
authors.affiliation: Department of Rheumatology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Ding-Ya
authors.initials: DY
authors.lastname: Fang
mesh_terms: D000328:Adult; D018771:Arthralgia / Q000188:drug therapy*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*
chemical_list: D004365:Drugs, Chinese Herbal