title: Protective effect of arctigenin against MPP+ and MPTP-induced neurotoxicity.
abstract: The potential protective effects of arctigenin on 1-methyl-4-phenylpyridinium ion and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyride-induced neurotoxicity were examined, and the results indicated that arctigenin could improve the movement behaviors and upregulate dopamine and γ-aminobutyric acid levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyride-induced neurotoxicity mouse model. A further in vitro experiment showed that the pretreatment with arctigenin on cultured human neuroblastoma SH-SY5Y cells could obviously attenuate the decrease of cell survival rates caused by treatment with 1-methyl-4-phenylpyridinium ion by way of acting against cell apoptosis through the decrease of Bax/Bcl-2 and caspase-3, and by antioxidative action through reduction of the surplus reactive oxygen species production and downregulation of mitochondrial membrane potential. It is for the first time that a neuroprotective activity of arctigenin in both in vitro and in vivo experiments was reported, enlightening that arctigenin could be useful as a potential therapeutic agent for Parkinson's disease.
authors.affiliation: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning, China.
authors.forename: Dongwei
authors.initials: D
authors.lastname: Li
authors.affiliation: College of Life Science and Technology, Dalian University, Liaoning, China.
authors.forename: Qingping
authors.initials: Q
authors.lastname: Liu
authors.affiliation: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Jia
authors.affiliation: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning, China.
authors.forename: Deqiang
authors.initials: D
authors.lastname: Dou
authors.affiliation: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning, China.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Wang
authors.affiliation: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Liaoning, China.
authors.forename: Tingguo
authors.initials: T
authors.lastname: Kang
mesh_terms: D015655:1-Methyl-4-phenylpyridinium / Q000633:toxicity*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D005663:Furans / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000494:pharmacology*; D020267:MPTP Poisoning / Q000517:prevention & control*; D008297:Male; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D020258:Neurotoxicity Syndromes / Q000473:pathology / Q000517:prevention & control*; D010300:Parkinson Disease / Q000188:drug therapy; D051028:bcl-2-Associated X Protein / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: C494826:BAX protein, human; D005663:Furans; D017705:Lignans; D018696:Neuroprotective Agents; D051028:bcl-2-Associated X Protein; D005680:gamma-Aminobutyric Acid; D015655:1-Methyl-4-phenylpyridinium; C071942:arctigenin; D004298:Dopamine