title: Overexpression of β-catenin and cyclinD1 predicts a poor prognosis in ovarian serous carcinomas.
abstract: Ovarian serous cancer is the most common subtype of epithelial ovarian cancer, and is the leading cause of death from gynecologic cancer. There is an important need for exploration of diagnostic and prognostic markers for this disease. β-catenin and cyclinD1 play central roles in the tumorigenesis for certain cancers. The role of β-catenin and cyclinD1 in diagnosis and prognosis of ovarian serous carcinoma is uncertain. In the present study, the expression of β-catenin and cyclinD1 was examined in 60 ovarian serous carcinomas patients with immunohistochemical staining. The relationship between expression of β-catenin and cyclinD1 and FIGO stage, pathological grade was analyzed. Kaplan-Meier survival function was used to analyze the prognosis. Overexpression of β-catenin is more often detected in patients with FIGO stage III and IV than in those with stage I, and II (P=0.003). No significant relationship was found between expression of β-catenin and pathological grade (P=0.817). Positive expression of β-catenin related to lower survival rate (P=0.034). The expression of cyclinD1 had no relationship with FIGO stage (P=0.829). Overexpression of cyclinD1 was positively to pathological grade (P=0.017) and survival rate (P=0.009). There is a significantly positive relationship between expression of β-catenin and cyclinD1 (P=0.014). No statistical significance was found between expression of β-catenin and cyclinD1 and other pathological parameters.
  
  
  CONCLUSIONS
  Expression of β-catenin and cyclinD1 may be used as predict markers for poor prognosis.
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University School of Medicine Nanjing 210002, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University School of Medicine Nanjing 210002, China.
authors.forename: Haiyan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Anatomy & Neurobiology, Northeast Ohio Medical University Rootstown, OH 44272, USA.
authors.forename: Mohammad Shahidul
authors.initials: MS
authors.lastname: Makki
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University School of Medicine Nanjing 210002, China.
authors.forename: Juanjuan
authors.initials: J
authors.lastname: Wen
authors.affiliation: Department of Obstetrics and Gynecology, Jinling Hospital, Nanjing University School of Medicine Nanjing 210002, China.
authors.forename: Yingqing
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University School of Medicine Nanjing 210002, China.
authors.forename: Qunli
authors.initials: Q
authors.lastname: Shi
authors.affiliation: Department of Obstetrics and Gynecology, Jinling Hospital, Nanjing University School of Medicine Nanjing 210002, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Liu
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University School of Medicine Nanjing 210002, China.
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Department of Pathology, Jinling Hospital, Nanjing University School of Medicine Nanjing 210002, China.
authors.forename: Jiandong
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D019938:Cyclin D1 / Q000032:analysis / Q000096:biosynthesis*; D018284:Cystadenocarcinoma, Serous / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D015854:Up-Regulation; D055815:Young Adult; D051176:beta Catenin / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; C530104:CCND1 protein, human; C495270:CTNNB1 protein, human; D051176:beta Catenin; D019938:Cyclin D1
keywords: cyclinD1; ovarian serous carcinoma; prognosis; β-catenin