title: Increased Levels of Metalloproteinase 10 and Hemostatic Markers in Patients With Noncomplicated Primary Varicose Veins.
abstract: The purpose of the study was to analyze a systemic activation of hemostasis and concentration of matrix metalloproteinase 10 (MMP-10) in patients with primary varicose veins (PVVs). A study group consisted of 41 patients with noncomplicated PVVs. A control group consisted of 30 age- and sex-matched healthy individuals without varicose veins. The concentration of d-dimers (DD), prothrombin fragments 1 and 2 (F1+2), antigen of von Willebrand factor (vWF), and activity of plasminogen activator inhibitor (PAI-1) in plasma and concentration of MMP-10 in serum were analyzed. In patients with PVVs, higher concentrations of DD (P < .001), F1+2 (P < .001), vWF (P = .027), MMP-10 (P = .006), and higher activity of PAI-1 (P < .001) were observed. However, no correlation between the concentrations of MMP-10 and prothrombotic markers was found. Noncomplicated PVVs are associated with systemic, prothrombotic activation of hemostasis and increased concentration of MMP-10, suggesting a prothrombotic and proinflammatory state.
authors.affiliation: Department of Angiology and Vascular Surgery, University Hospital of Navarra, Pamplona, Spain Department of General and Vascular Surgery, Poznań University of Medical Sciences, Poznan, Poland l_dzieciuchowicz@wp.pl.
authors.forename: Lukasz
authors.initials: L
authors.lastname: Dzieciuchowicz
authors.affiliation: Department of Angiology and Vascular Surgery, University Hospital of Navarra, Pamplona, Spain.
authors.forename: Gaudencio
authors.initials: G
authors.lastname: Espinosa
authors.affiliation: Department of Hematology, University Hospital of Navarra, Pamplona, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Páramo
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D006801:Humans; D008297:Male; D053506:Matrix Metalloproteinase 10 / Q000097:blood*; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood; D011498:Protein Precursors / Q000097:blood; D011516:Prothrombin; D014648:Varicose Veins / Q000097:blood*
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D010446:Peptide Fragments; D011498:Protein Precursors; C036309:fibrin fragment D; C029733:prothrombin fragment 1; C044183:prothrombin fragment 2; D011516:Prothrombin; C511770:MMP10 protein, human; D053506:Matrix Metalloproteinase 10
keywords: hemostasis; matrix metalloproteinase 10; varicose veins