title: Risk assessment to predict arterial and venous events in patients undergoing percutaneous coronary intervention.
abstract: Atherosclerosis and venous thromboembolism (VTE) share common risk factors. We set to assess the strength of the association between atherosclerosis risk factors and disease manifestation, and VTE, in patients with coronary artery disease undergoing percutaneous coronary intervention. We pooled data from 6 global randomized controlled trials assessing coronary stenting (ENDEAVOR and SIRIUS programs), developed separate risk scores to predict major adverse cardiac and cerebrovascular events (MACCEs: cardiac death, myocardial infarction, and stroke) and VTE, and compared their performance. The 5-year rates of MACCE and VTE were 10.8% and 2.04%, respectively. Selected predictors for MACCE performed equally well in predicting VTE (area under the receiver-operating characteristic curve [AUC] 0.651 vs 0.672), and selected predictors for VTE performed equally well in predicting MACCE (AUC 0.699 vs 0.620). Ejection fraction and age were associated with both MACCE and VTE. These findings support the concept of overlapping pathophysiology of VTE and atherothrombosis.
authors.affiliation: Harvard Clinical Research Institute, Boston, MA, USA moshe.vardi@hcri.harvard.edu.
authors.forename: Moshe
authors.initials: M
authors.lastname: Vardi
authors.affiliation: Cardiovascular Division, Brigham and Women Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA.
authors.forename: Gregory
authors.initials: G
authors.lastname: Piazza
authors.affiliation: Department of Biostatistics, Boston University, MA, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pencina
authors.affiliation: Harvard Clinical Research Institute, Boston, MA, USA Cardiology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Burke
authors.affiliation: Harvard Clinical Research Institute, Boston, MA, USA.
authors.forename: Lanyu
authors.initials: L
authors.lastname: Lei
authors.affiliation: Cardiovascular Division, Brigham and Women Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA.
authors.forename: Samuel Z
authors.initials: SZ
authors.lastname: Goldhaber
authors.affiliation: Harvard Clinical Research Institute, Boston, MA, USA Harvard Medical School, Boston, MA, USA Cardiology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA.
authors.forename: Donald E
authors.initials: DE
authors.lastname: Cutlip
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D011183:Postoperative Complications / Q000453:epidemiology* / Q000503:physiopathology; D011446:Prospective Studies; D018570:Risk Assessment; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D013318:Stroke Volume; D054556:Venous Thromboembolism / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology
keywords: atherosclerosis; risk factors; risk score; venous thromboembolism