title: Metabolic, behavioral, and reproductive effects of vertical sleeve gastrectomy in an obese rat model of polycystic ovary syndrome.
abstract: BACKGROUND
  Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Its clinical expression is diverse, including metabolic, behavioral, and reproductive effects, with many affected by obesity and decreased quality of life. Women with PCOS who have undergone surgically induced weight loss have reported tremendous benefit, not only with weight loss, but also improvement of hyperandrogenism and menstrual cyclicity.
  
  
  METHODS
  In a rat model of PCOS achieved via chronic administration of dihydrotestosterone (DHT) exposure, we investigated the ability of bariatric surgery, specifically vertical sleeve gastrectomy (VSG), to ameliorate the metabolic, behavioral, and reproductive abnormalities invoked by this PCOS model.
  
  
  RESULTS
  We found that DHT treatment combined with exposure to a high-fat diet resulted in increased body weight and body fat, impaired fasting glucose, hirsutism, anxiety, and irregular cycles. VSG resulted in reduced food intake, body weight, and adiposity with improved fasting glucose and triglycerides. VSG induced lower basal corticosterone levels and attenuated stress responsivity. Once the DHT levels decreased to normal, regular estrous cyclicity was also restored.
  
  
  CONCLUSIONS
  VSG, therefore, improved PCOS manifestations in a comprehensive manner and may represent a potential therapeutic approach for specific aspects of PCOS.
authors.affiliation: Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH, 45267, USA.
authors.forename: Ilana B
authors.initials: IB
authors.lastname: Ressler
authors.forename: Bernadette E
authors.initials: BE
authors.lastname: Grayson
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Seeley
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001835:Body Weight; D003345:Corticosterone / Q000097:blood; D004195:Disease Models, Animal; D005260:Female; D005743:Gastrectomy / Q000379:methods; D009765:Obesity / Q000453:epidemiology* / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000453:epidemiology* / Q000378:metabolism / Q000628:therapy*; D051381:Rats
chemical_list: D000324:Adrenocorticotropic Hormone; D003345:Corticosterone