title: A Comparative Study of CEE, Tibolone, and DHEA as Hormone Replacement Therapy for Surgical Menopause.
abstract: OBJECTIVE
  The objective of this study was to compare the efficacy and safety of CEE, tibolone, and DHEA for prevention of menopausal symptoms.
  
  
  METHODS
  One hundred patients with surgical menopause were included in this study: 25 of whom were not treated with any HRT, 25 were treated with 0.625 mg of CEE, 25 were treated with 2.5 mg of tibolone, and 25 were treated with 25 mg of DHEA for 1 year, and the results were statistically analyzed regarding drug efficacy and side effects at follow-up periods of 1, 6 and 12 months.
  
  
  RESULTS
  Frequency of menopausal symptoms was significantly less in cases received with CEE, tibolone, DHEA with p values 0.001, 0.004 and 0.004, respectively. Percentage gain in BMD was 2.8 % with CEE at lumbar spine, which was greater than that caused by DHEA and tibolone, but this difference was not statistically significant. CEE caused side effects like headache (40 %) and nausea (28 %).
  
  
  CONCLUSIONS
  CEE, Tibolone, and DHEA are very effective in alleviating climacteric symptoms. CEE has beneficial effects on lipid and bone and is a low-cost drug but frequently causes side effects. Tibolone offers beneficial androgenic effects on mood and libido with fewer side effects but is a costly drug. DHEA shows positive effects on psychological symptoms. However, its cost and androgenic side effects limit its use as long-term HRT.
authors.affiliation: Department of Obstetrics & Gynaecology, SMS Medical College, Jaipur, Rajasthan India.
authors.forename: Bhawna
authors.initials: B
authors.lastname: Gupta
authors.affiliation: Department of Obstetrics & Gynaecology, SMS Medical College, Jaipur, Rajasthan India.
authors.forename: Preeti
authors.initials: P
authors.lastname: Mittal
authors.affiliation: Department of Obstetrics & Gynaecology, SMS Medical College, Jaipur, Rajasthan India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Khuteta
authors.affiliation: Department of Obstetrics & Gynaecology, SMS Medical College, Jaipur, Rajasthan India.
authors.forename: Adarsh
authors.initials: A
authors.lastname: Bhargava
keywords: Climacteric; HRT; Menopause