title: Clinical proteomics in obstetrics and neonatology.
abstract: Clinical proteomics has been applied to the identification of biomarkers of obstetric and neonatal disease. We will discuss a number of encouraging studies that have led to potentially valid biomarkers in the context of Down's syndrome, preterm birth, amniotic infections, preeclampsia, intrauterine growth restriction and obstructive uropathies. Obtaining noninvasive biomarkers (e.g., from the maternal circulation, urine or cervicovaginal fluid) may be more feasible for obstetric diseases than for diseases of the fetus, for which invasive methods are required (e.g., amniotic fluid, fetal urine). However, studies providing validated proteomics-identified biomarkers are limited. Efforts should be made to save well-characterized samples of these invasive body fluids so that many valid biomarkers of pregnancy-related diseases will be identified in the coming years using proteomics based analysis upon adoption of 'clinical proteomics guidelines'.
authors.affiliation: Mosaiques diagnostics & therapeutics, Hannover, Germany.
authors.forename: Julie
authors.initials: J
authors.lastname: Klein
authors.forename: Benedicte
authors.initials: B
authors.lastname: Buffin-Meyer
authors.forename: William
authors.initials: W
authors.lastname: Mullen
authors.forename: David M
authors.initials: DM
authors.lastname: Carty
authors.forename: Christian
authors.initials: C
authors.lastname: Delles
authors.forename: Antonia
authors.initials: A
authors.lastname: Vlahou
authors.forename: Harald
authors.initials: H
authors.lastname: Mischak
authors.forename: Stéphane
authors.initials: S
authors.lastname: Decramer
authors.forename: Jean-Loup
authors.initials: JL
authors.lastname: Bascands
authors.forename: Joost P
authors.initials: JP
authors.lastname: Schanstra
mesh_terms: D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry; D015415:Biomarkers / Q000032:analysis; D035843:Biomedical Research; D004314:Down Syndrome / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005315:Fetal Diseases / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D009359:Neonatology / Q000379:methods*; D009774:Obstetrics / Q000379:methods*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis / Q000652:urine; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000378:metabolism; D047928:Premature Birth / Q000175:diagnosis / Q000378:metabolism; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods*
chemical_list: D015415:Biomarkers; D020543:Proteome