title: Beneficial effects of black yeast derived 1-3, 1-6 Beta Glucan-Nichi Glucan in a dyslipidemic individual of Indian origin--a case report.
abstract: Dyslipidemia is a major risk factor for the development of cardiovascular diseases and statins are the common drugs used to correct dyslipidemia. Herein, we report a case where the subject was a nondiabetic, dyslipidemia patient on medication with Rosuvastatin. After the intake of Rosuvastatin, his triglycerides decreased to a minimum of 220 mg/dL. In order to augment the action of Rosuvastatin, he was advised to take 1.5 mg of Nichi Glucan food supplement, which is a 1,3-1,6 Beta Glucan derived from the black yeast, Aureobasidium pullulans, daily for 2 months. At the end of 2 months, his triglyceride levels decreased from 523 mg/dL (at start of the study) to 175 mg/dL. His VLDL levels, which were 104.6 mg/dL at the start of the study decreased to 35 mg/dL and the HDL cholesterol levels increased from 27 to 38 mg/dL. This is a first of its kind report on the effect of the black yeast derived 1,3-1,6 Beta Glucans on dyslipidemia not associated with diabetes. Thus supplementation of Nichi Glucan, 1,3- 1,6 Beta Glucan derived from the black yeast along with the routine medications was beneficial to treat dyslipidemia and a larger trial is needed to confirm the effects.
authors.affiliation: 1The Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), Nungambakkam, Chennai 600034, India.
authors.forename: Jegatheesan Saravana
authors.initials: JS
authors.lastname: Ganesh
authors.forename: Yegneswara Yellury
authors.initials: YY
authors.lastname: Rao
authors.forename: Ratnagiri
authors.initials: R
authors.lastname: Ravikumar
authors.forename: Gosalakkal A
authors.initials: GA
authors.lastname: Jayakrishnan
authors.forename: Masaru
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Senthilkumar
authors.initials: S
authors.lastname: Preethy
authors.forename: Samuel J K
authors.initials: SJ
authors.lastname: Abraham
mesh_terms: D001688:Biological Products / Q000494:pharmacology / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood*; D019587:Dietary Supplements; D004359:Drug Therapy, Combination; D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy*; D005464:Fluorobenzenes / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*; D015003:Yeasts / Q000737:chemistry*; D047071:beta-Glucans / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D001688:Biological Products; D005464:Fluorobenzenes; D011743:Pyrimidines; D013449:Sulfonamides; D014280:Triglycerides; D047071:beta-Glucans; D000068718:Rosuvastatin Calcium; D002784:Cholesterol