title: Antimicrobial activity of cationic gemini surfactant containing an oxycarbonyl group in the lipophilic portion against gram-positive and gram-negative microorganisms.
abstract: We evaluated the antimicrobial activities of a cationic Gemini surfactant, trans-1,4-bis[2-(alkanoyloxy)ethyldimethylammonio]-2-butene dichloride [II-m-2(t-butene)] and its derivatives against Gram-positive and Gram-negative microorganisms. The II-m-2(t-butene) compound was previously shown to have good surface activity and biodegradability. A dodecanoyloxy derivative (m = 12) of II-m-2(t-butene) showed excellent antimicrobial activity against Gram-positive Streptococcus aureus [minimum inhibitory concentration (MIC): 7.8 μg/mL] and Gram-negative Escherichia coli (MIC: 31.2 μg/mL).
authors.affiliation: Faculty of Education, Wakayama University.
authors.forename: Taiga
authors.initials: T
authors.lastname: Tatsumi
authors.forename: Yoshitane
authors.initials: Y
authors.lastname: Imai
authors.forename: Kakuhiro
authors.initials: K
authors.lastname: Kawaguchi
authors.forename: Naoko
authors.initials: N
authors.lastname: Miyano
authors.forename: Isao
authors.initials: I
authors.lastname: Ikeda
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D001711:Biotransformation; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects*; D008968:Molecular Conformation; D013211:Staphylococcus aureus / Q000187:drug effects*; D013501:Surface-Active Agents / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: C411462:1,25-dihydroxy-21-(3-hydroxy-3-methylbutyl)vitamin D(3); D000475:Alkenes; D000900:Anti-Bacterial Agents; D013501:Surface-Active Agents; D002117:Calcitriol; C021639:2-butene