title: Update on membranoproliferative GN.
abstract: Membranoproliferative GN represents a pattern of injury seen on light microscopy. Historically, findings on electron microscopy have been used to further subclassify this pathologic entity. Recent advances in understanding of the underlying pathobiology have led to a proposed classification scheme based on immunofluorescence findings. Dysregulation of the complement system has been shown to be a major risk factor for the development of a membranoproliferative GN pattern of injury on kidney biopsy. Evaluation and treatment of this complex disorder rest on defining the underlying mechanisms.
authors.affiliation: Division of Nephrology, Winthrop University Hospital, Mineola, New York, †Division of Kidney Diseases and Hypertension, Hofstra North Shore-Long Island Jewish School of Medicine, Great Neck, New York.
authors.forename: Naveed
authors.initials: N
authors.lastname: Masani
authors.forename: Kenar D
authors.initials: KD
authors.lastname: Jhaveri
authors.forename: Steven
authors.initials: S
authors.lastname: Fishbane
mesh_terms: D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D005455:Fluorescent Antibody Technique; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D011237:Predictive Value of Tests; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers