title: Transmitted drug resistance and antiretroviral treatment outcomes in non-subtype B HIV-1-infected patients in South East Asia.
abstract: BACKGROUND
  We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens.
  
  
  METHODS
  Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models.
  
  
  RESULTS
  TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR.
  
  
  CONCLUSIONS
  TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.
authors.affiliation: *HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; †Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; ‡The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; §Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; ‖YRG Centre for AIDS Research and Education, Chennai, India; ¶Queen Elizabeth Hospital, Hong Kong, China; #Research Institute for Health Sciences, Chiang Mai University, Chiang Mai, Thailand; **Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; ††Hospital Sungai Buloh, Kuala Lumpur, Malaysia; ‡‡University of Malaya, Kuala Lumpur, Malaysia; §§Hospital Raja Perempuan Zainab II, Kota Bharu, Malaysia; ‖‖Research Institute for Tropical Medicine, Manila, Philippines; ¶¶Faculty of Medicine, Udayana University and Sanglah Hospital, Bali, Indonesia; ##Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand; ***TREAT Asia, amfAR-The Foundation for AIDS Research, Bangkok, Thailand; and †††Brown University Alpert Medical School, Providence, RI.
authors.forename: Praphan
authors.initials: P
authors.lastname: Phanuphak
authors.forename: Sunee
authors.initials: S
authors.lastname: Sirivichayakul
authors.forename: Awachana
authors.initials: A
authors.lastname: Jiamsakul
authors.forename: Somnuek
authors.initials: S
authors.lastname: Sungkanuparph
authors.forename: Nagalingeswaran
authors.initials: N
authors.lastname: Kumarasamy
authors.forename: Man Po
authors.initials: MP
authors.lastname: Lee
authors.forename: Thira
authors.initials: T
authors.lastname: Sirisanthana
authors.forename: Pacharee
authors.initials: P
authors.lastname: Kantipong
authors.forename: Christopher
authors.initials: C
authors.lastname: Lee
authors.forename: Adeeba
authors.initials: A
authors.lastname: Kamarulzaman
authors.forename: Mahiran
authors.initials: M
authors.lastname: Mustafa
authors.forename: Rossana
authors.initials: R
authors.lastname: Ditangco
authors.forename: Tuti
authors.initials: T
authors.lastname: Merati
authors.forename: Winai
authors.initials: W
authors.lastname: Ratanasuwan
authors.forename: Thida
authors.initials: T
authors.lastname: Singtoroj
authors.forename: Rami
authors.initials: R
authors.lastname: Kantor
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001210:Asia, Southeastern / Q000453:epidemiology; D024882:Drug Resistance, Viral; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D044966:Anti-Retroviral Agents