title: Fatal Cryptococcus gattii genotype AFLP5 infection in an immunocompetent Cuban patient.
abstract: We describe the first clinical case of cryptococcosis due C. gattii in a Cuban immunocompetent patient who had a traveling history two years before to Central America. Molecular characterization of the isolate showed it to be genotype AFLP5 of which MLST sequences clustered with clinical and environmental strains from Colombia. The patient died one year after the diagnosis despite a prolonged treatment with (liposomal) amphotericin B, fluconazole, voriconazole and gamma interferon.
authors.affiliation: Department of Microbiology, Tropical Medicine Institute "Pedro Kouri", P.O. Box 601, Havana, Cuba.
authors.forename: María T
authors.initials: MT
authors.lastname: Illnait-Zaragozí
authors.affiliation: Intensive Care Unit, Tropical Medicine Institute "Pedro Kouri", P.O. Box 601, Havana, Cuba.
authors.forename: Lilia M
authors.initials: LM
authors.lastname: Ortega-Gonzalez
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, PO Box 9015, Nijmegen 6500 GS, The Netherlands.
authors.forename: Ferry
authors.initials: F
authors.lastname: Hagen
authors.affiliation: Department of Microbiology, Tropical Medicine Institute "Pedro Kouri", P.O. Box 601, Havana, Cuba.
authors.forename: Gerardo F
authors.initials: GF
authors.lastname: Martínez-Machin
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, PO Box 9015, Nijmegen 6500 GS, The Netherlands ; Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500 HB, The Netherlands.
authors.forename: Jacques F
authors.initials: JF
authors.lastname: Meis
keywords: AFLP5; C. gattii; Cryptococcal meningitis; Imported mycoses; Treatment