title: Donor management and lung preservation for lung transplantation.
abstract: Although lung transplantation has become a life-saving option for patients with end-stage lung disease, this intervention is hampered by a shortage of lungs in view of the growing number of people on the waiting list. Lungs are retrieved from only a small percentage of multiorgan donors, and the transplantation and intensive-care communities have recognised the need to develop innovative methods to expand the donor pool. Advancements in lung-preservation techniques in the preretrieval and postretrieval periods have increased the pool of available donors, and novel research and discoveries in this area have steadily improved post-transplantation adverse events. This Review summarises current best practice and the latest research on intensive-care management of a potential lung donor. We also discuss lung-preservation techniques, including advancements in normothermic ex-vivo lung perfusion, and the potential for a personalised medicine approach to the organ.
authors.affiliation: Toronto General Hospital, University of Toronto, Toronto, ON, Canada.
authors.forename: Laveena
authors.initials: L
authors.lastname: Munshi
authors.affiliation: Toronto General Hospital, University of Toronto, Toronto, ON, Canada.
authors.forename: Shaf
authors.initials: S
authors.lastname: Keshavjee
authors.affiliation: Toronto General Hospital, University of Toronto, Toronto, ON, Canada. Electronic address: marcelo.cypel@uhn.ca.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cypel
mesh_terms: D006801:Humans; D016040:Lung Transplantation / Q000379:methods*; D009926:Organ Preservation / Q000379:methods*; D012131:Respiratory Insufficiency / Q000601:surgery*; D014019:Tissue Donors / Q000600:supply & distribution*; D014850:Waiting Lists