title: Treating malaria in pregnancy in developing countries: priorities in clinical research and drug development.
abstract: Reducing the burden of falciparum malaria in pregnancy is an urgent international public health priority but one that involves considerable challenges. The rapidly declining effectiveness of agents known to be safe in pregnancy, and the limited efficacy, safety and pharmacokinetic data available for many other antimalarial drugs, mean that current options for the treatment of both severe and uncomplicated falciparum malaria in pregnancy are limited. This report summarizes the literature on this subject and recommends drug combinations for evaluation in Phase II/III treatment trials in pregnancy.
authors.affiliation: Senior Lecturer, Tropical & Infectious Diseases, University of Queensland, Division of International and Indigenous Health, School of Population Health, Herston Road, Herston, Brisbane Qld 4006, Australia. a.vallely@uq.edu.au.
authors.forename: Andrew
authors.initials: A
authors.lastname: Vallely
authors.forename: James
authors.initials: J
authors.lastname: McCarthy
authors.forename: John
authors.initials: J
authors.lastname: Changalucha
authors.forename: Lisa
authors.initials: L
authors.lastname: Vallely
authors.forename: Daniel
authors.initials: D
authors.lastname: Chandramohan