title: [Pharmacological activity of runihol and S-adenosyl-L-methionine in rats with experimental liver damage by reserve antituberculosis drugs].
abstract: The hepatoprotective action of runihol and S-adenosyl-L-methionine (ademethionine) has been studied in a group of 47 white outbred male rats with model liver injury induced by reserve antituberculosis drugs (PAS, prothionamide, cycloserine). The ability of test drugs to correct structural and functional liver disorders is established. Both runihol and ademethionine favored decrease in the signs of structural and functional liver disorders induced by reserve antituberculosis drugs, Showing mixed type of action, the test drugs promoted recovery of the liver parenchyma and reduced manifestations of hepatocyte dystrophy to the same extent, without manifestations of necrobiotic processes and a mononuclear infiltration.
authors.forename: D S
authors.initials: DS
authors.lastname: Sukhanov
authors.forename: T I
authors.initials: TI
authors.lastname: Vinogradova
authors.forename: N V
authors.initials: NV
authors.lastname: Zabolotnykh
authors.forename: S V
authors.initials: SV
authors.lastname: Okovityĭ
authors.forename: S N
authors.initials: SN
authors.lastname: Vasil'eva
authors.forename: M L
authors.initials: ML
authors.lastname: Vitovskaia
mesh_terms: D010131:Aminosalicylic Acid / Q000009:adverse effects; D000818:Animals; D021461:Animals, Outbred Strains; D000995:Antitubercular Agents / Q000009:adverse effects*; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D003523:Cycloserine / Q000009:adverse effects; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007288:Inosine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008715:Methionine / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology*; D011515:Prothionamide / Q000009:adverse effects; D051381:Rats; D012436:S-Adenosylmethionine / Q000494:pharmacology; D019802:Succinic Acid / Q000494:pharmacology; D013654:Taurine / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
chemical_list: D000995:Antitubercular Agents; D020011:Protective Agents; D014280:Triglycerides; D013654:Taurine; D007288:Inosine; D010131:Aminosalicylic Acid; D011515:Prothionamide; D012436:S-Adenosylmethionine; D003523:Cycloserine; D002784:Cholesterol; D019802:Succinic Acid; D008715:Methionine; D001663:Bilirubin