title: In-vitro evaluation of bioactive compounds, anti-oxidant, lipid peroxidation and lipoxygenase inhibitory potential of Citrus karna L. peel extract.
abstract: Many medicinal plants have been studied for their antioxidant and their pharmacological activity. Citrus species were well documented as potential antioxidant based therapy for cancer, inflammation, heart disease. Citrus seeds and peels have been shown to possess high antioxidant activity. Therefore, the present study to explore the antioxidant and lipid peroxidation & lipoxygenase inhibitory action of Citrus karna peel extracts were undertaken. Extraction was performed with different solvents of increasing polarity and yield was calculated. Peel extracts were also analyzed for the presence of phenols, flavonoids, vitamin C, and carotenoids. Then the Citrus karna peel extracts were evaluated for the antioxidant and lipid peroxidation & lipoxygenase inhibitory action In-Vitro. In further, the quantification of hesperidin and naringin was carried out by HPLC-DAD method. The results indicated the presence of phenols, flavonoids, vitamin C, carotenoids, hesperidin and naringin in Citrus karna peel extracts with maximum yield of (3.91% w/w). Citrus karna peel extracts were also found to have potential antioxidant and lipid peroxidation & lipoxygenase inhibitory action. Therefore, Citrus karna peel extracts could be used for the future therapeutic medicine due to presence of potential bioactive compounds.
authors.affiliation: Rayat Institute of Pharmacy, Nawanshahr District Near Ropar, Distt Shaheed Bhagat Singh Nagar, Railmajra, Punjab 144533 India.
authors.forename: Jagdeep
authors.initials: J
authors.lastname: Singh
authors.affiliation: Rayat Institute of Pharmacy, Nawanshahr District Near Ropar, Distt Shaheed Bhagat Singh Nagar, Railmajra, Punjab 144533 India.
authors.forename: Shailja
authors.initials: S
authors.lastname: Sood
authors.affiliation: Rayat Institute of Pharmacy, Nawanshahr District Near Ropar, Distt Shaheed Bhagat Singh Nagar, Railmajra, Punjab 144533 India ; Department of Pharmaceutical Sciences & Drug Research, Punjabi University, Patiala, 147002 Punjab India.
authors.forename: Arunachalam
authors.initials: A
authors.lastname: Muthuraman
keywords: Citrus karna; Free radical; Hesperidin; Lipoxygenase; Naringin