title: Inflammatory biomarker pentraxin 3 (PTX3) in relation to obesity, body fat depots and weight loss.
abstract: OBJECTIVE
  The relation between inflammatory markers, adiposity and disease is under extensive study. Here we tested the hypothesis that the immunomodulatory protein pentraxin 3 (PTX3) is associated with adiposity in the general population.
  
  
  METHODS
  Serum PTX3 concentrations, body mass index (BMI), waist circumference (WC) and fat depots, as quantified by dual-energy X-ray absorptiometry and magnetic resonance imaging, were assessed in three community-based cohorts: ULSAM, n = 790, mean age 78 years; PIVUS, n = 1003, mean age 70 years, women 50%; and the NORDIET-trial, n = 86, mean age 53 years, women 63%. Participants were re-examined after 5 years (PIVUS, n = 804) or following a 6-week randomized controlled dietary intervention (NORDIET).
  
  
  RESULTS
  PTX3 levels were inversely associated with BMI and WC as well as with total and visceral fat (P < 0.05 for all; adjusted for age, inflammatory biomarkers and cardiovascular risk factors). The association between PTX3 and BMI appeared even stronger in nonobese individuals. A decrease in BMI over 5 years as well as weight loss following the NORDIET intervention were associated with increased serum PTX3 concentrations (P < 0.001).
  
  
  CONCLUSIONS
  These consistent data support an inverse association between circulating PTX3 and anthropometrical measures, calling for further mechanistic studies of the link between PTX3 and fat.
authors.affiliation: Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Division of Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Anna
authors.initials: A
authors.lastname: Witasp
authors.forename: Juan Jesús
authors.initials: JJ
authors.lastname: Carrero
authors.forename: Karl
authors.initials: K
authors.lastname: Michaëlsson
authors.forename: Håkan
authors.initials: H
authors.lastname: Ahlström
authors.forename: Joel
authors.initials: J
authors.lastname: Kullberg
authors.forename: Viola
authors.initials: V
authors.lastname: Adamsson
authors.forename: Ulf
authors.initials: U
authors.lastname: Risérus
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
authors.forename: Johanna
authors.initials: J
authors.lastname: Helmersson-Karlqvist
authors.forename: Lars
authors.initials: L
authors.lastname: Lind
authors.forename: Peter
authors.initials: P
authors.lastname: Stenvinkel
authors.forename: Johan
authors.initials: J
authors.lastname: Arnlöv
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D050154:Adiposity; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics; D003430:Cross-Sectional Studies; D005247:Feeding Behavior; D005500:Follow-Up Studies; D005819:Genetic Markers; D007249:Inflammation / Q000097:blood / Q000235:genetics; D008137:Longitudinal Studies; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D011446:Prospective Studies; D015203:Reproducibility of Results; D000683:Serum Amyloid P-Component / Q000235:genetics / Q000378:metabolism; D013548:Sweden; D055105:Waist Circumference; D015431:Weight Loss; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D005819:Genetic Markers; D000683:Serum Amyloid P-Component; D000099153:Pentraxins