title: Randomized, within-patient, clinical trial comparing fluorine-synthetic fiber socks with standard cotton socks in improving plantar pustulosis.
abstract: OBJECTIVE
  Rubbing the skin may influence the persistence of pustulosis over time. The aim of this study was to assess the impact of a new fabric made with fluorine-synthetic fiber in improving plantar pustulosis.
  
  
  METHODS
  A total of 17 patients were randomized to receive on one side a sock made of fluorine-synthetic fiber and on the other a sock made of cotton fabric for 4 weeks. The main outcome was the percentage reduction of lesional area at week 4.
  
  
  RESULTS
  The median lesion reduction at week 4 was 42.6% in the fluorine-synthetic fiber arm and 2.7% in the cotton arm (p = 0.148). Among secondary outcomes, the overall reduction over time in the treated areas was significantly in favor of the fluorine-synthetic fiber arm (p = 0.045) as well as the perception of the disease by the patient (p = 0.025).
  
  
  CONCLUSIONS
  Despite the fact that the primary outcome was not reached, there was a tangible reduction in the extension of the treated areas and in the perception of the disease by the patient.
authors.affiliation: Centro Studi GISED, Fondazione per la Ricerca Ospedale Maggiore, Bergamo, Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Cazzaniga
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lo Scocco
authors.forename: Emiliano
authors.initials: E
authors.lastname: Schincaglia
authors.forename: Santo Raffaele
authors.initials: SR
authors.lastname: Mercuri
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
authors.forename: Rosita
authors.initials: R
authors.lastname: Saraceno
authors.forename: Luigi
authors.initials: L
authors.lastname: Naldi
mesh_terms: D000328:Adult; D003020:Clothing; D032561:Cotton Fiber; D003880:Dermatology; D005260:Female; D005461:Fluorine / Q000627:therapeutic use; D017611:Fluorine Compounds / Q000627:therapeutic use; D005533:Foot Dermatoses / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009757:Nylons; D011565:Psoriasis / Q000473:pathology / Q000628:therapy*; D011788:Quality of Life; D013784:Textiles; D016896:Treatment Outcome
chemical_list: D017611:Fluorine Compounds; D009757:Nylons; D005461:Fluorine