title: The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8+T cells into innate-like effector cells with antitumor activity.
abstract: ALT-803, an interleukin-15-based superagonist, induces memory CD8+T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon γ and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and activation of memory CD8+T cells while converting them into innate immune effector cells that exhibit robust antineoplastic activity.
authors.affiliation: Altor BioScience Corporation; Miramar, FL USA.
authors.forename: Hing C
authors.initials: HC
authors.lastname: Wong
authors.affiliation: Altor BioScience Corporation; Miramar, FL USA.
authors.forename: Emily K
authors.initials: EK
authors.lastname: Jeng
authors.affiliation: Altor BioScience Corporation; Miramar, FL USA.
authors.forename: Peter R
authors.initials: PR
authors.lastname: Rhode
keywords: NKG2D; adaptive immunity; immunotherapy; innate immunity; interferon γ; interleukin-15; memory CD8+ T cells; myeloma; tumor