title: Patient awareness and approval for an opt-out genomic biorepository.
abstract: OBJECTIVE
  In this study, we sought to assess patient awareness and perceptions of an opt-out biorepository.
  
  
  METHODS
  We conducted exit interviews with adult patients and parents of pediatric patients having their blood drawn as part of their clinical care at Vanderbilt University Medical Center (TN, USA).
  
  
  RESULTS
  32.9% of all patients and parents of pediatric patients report having heard of the opt-out biorepository, while 92.4% approve of this research effort based on a brief description. Awareness that leftover blood could be used for research increased among adult patients during the study period, from 34.3 to 50.0%.
  
  
  CONCLUSIONS
  These findings will inform ongoing assessments of the suitability of opt-out and opt-in methods as alternatives to written informed consent for inclusion in a biorepository.
authors.affiliation: Center for Biomedical Ethics & Society, Vanderbilt University, Nashville, TN, USA ; Department of Pediatrics, Vanderbilt University & the Monroe Carell Jr.Children's Hospital at Vanderbilt, Nashville, TN, USA ; Kosair Charites Pediatric Clinical, Research Unit, Department of Pediatrics, University of Louisville, School of Medicine, Louisville, KY, USA.
authors.forename: Kyle B
authors.initials: KB
authors.lastname: Brothers
authors.affiliation: Center for Biomedical Ethics & Society, Vanderbilt University, Nashville, TN, USA.
authors.forename: Mathew J
authors.initials: MJ
authors.lastname: Westbrook
authors.affiliation: Center for Biomedical Ethics & Society, Vanderbilt University, Nashville, TN, USA.
authors.forename: M Frances
authors.initials: MF
authors.lastname: Wright
authors.affiliation: Child Health Services Research Unit, Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Myers
authors.affiliation: Center for Biomedical Ethics & Society, Vanderbilt University, Nashville, TN, USA ; Social Science Division, Pepperdine University, Malibu, CA, USA.
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Morrison
authors.affiliation: Office of Research, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Madison
authors.affiliation: Office of Research, Vanderbilt University School of Medicine, Nashville, TN, USA.
authors.forename: Jill M
authors.initials: JM
authors.lastname: Pulley
authors.affiliation: Center for Biomedical Ethics & Society, Vanderbilt University, Nashville, TN, USA ; Department of Pediatrics, Vanderbilt University & the Monroe Carell Jr.Children's Hospital at Vanderbilt, Nashville, TN, USA.
authors.forename: Ellen Wright
authors.initials: EW
authors.lastname: Clayton
keywords: exit interviews; human nonsubjects biorepository; iorepository; opt-out research; research ethics