title: Serum bromide concentrations following loading dose in epileptic dogs.
abstract: OBJECTIVE
  To determine serum bromide concentrations following an oral loading dose in dogs.
  
  
  METHODS
  Retrospective review of clinical records of dogs suffering from seizures that were treated with bromide. A loading dose of 600 mg/kg potassium bromide was administered orally in 17 to 48 hours together with a maintenance dose of 30 mg/kg/day. Blood samples were collected within 24 hours after completing the protocol and serum bromide concentrations were determined by ultra-violet gold chloride colorimetric assay.
  
  
  RESULTS
  Thirty-eight dogs were included in the study. The median age was 3 (range, 0 · 2 to 10) years and bodyweight 21 · 8 (3 · 45 to 46 · 2) kg. The median serum bromide concentration was 1 · 26 (0 · 74 to 3 · 6) mg/mL. Thirty-two dogs (84 · 2%) had serum bromide concentrations within the therapeutic interval (1 to 3 mg/mL). The serum concentration in five dogs (13 · 2%) was just under the minimal therapeutic value and in one dog (2 · 6%) it exceeded the maximal therapeutic value (3 · 6 mg/mL).
  
  
  CONCLUSIONS
  Following this oral loading dose protocol, serum bromide concentrations reach the therapeutic range in the majority of dogs. This indicates that the suggested protocol is effective in achieving therapeutic concentrations rapidly in epileptic dogs.
authors.affiliation: Dick White Referrals, Cambridgeshire, CB8 0UH.
authors.forename: B
authors.initials: B
authors.lastname: Gindiciosi
authors.affiliation: Dick White Referrals, Cambridgeshire, CB8 0UH.
authors.forename: V
authors.initials: V
authors.lastname: Palus
authors.affiliation: Dick White Referrals, Cambridgeshire, CB8 0UH.
authors.forename: S
authors.initials: S
authors.lastname: Eminaga
authors.affiliation: Dick White Referrals, Cambridgeshire, CB8 0UH.
authors.forename: E
authors.initials: E
authors.lastname: Villiers
authors.affiliation: Dick White Referrals, Cambridgeshire, CB8 0UH.
authors.forename: G
authors.initials: G
authors.lastname: Bruto Cherubini
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D001965:Bromides / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy*; D004285:Dogs; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D017680:Potassium Compounds / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D017680:Potassium Compounds; C039004:potassium bromide