title: Structured synaptic connectivity between hippocampal regions.
abstract: The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.
authors.affiliation: Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.
authors.forename: Shaul
authors.initials: S
authors.lastname: Druckmann
authors.affiliation: Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seoul, 136-791, Korea.
authors.forename: Linqing
authors.initials: L
authors.lastname: Feng
authors.affiliation: Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seoul, 136-791, Korea; Neuroscience program, University of Science and Technology, 176 Gajeongdong, Daejeon, 305-350, Korea.
authors.forename: Bokyoung
authors.initials: B
authors.lastname: Lee
authors.affiliation: Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seoul, 136-791, Korea; Department of Biological Science, KAIST, 373-1 Guseongdong, Daejeon, 305-701, Korea.
authors.forename: Chaehyun
authors.initials: C
authors.lastname: Yook
authors.affiliation: Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA.
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.affiliation: Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA. Electronic address: mageej@janelia.hhmi.org.
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Magee
authors.affiliation: Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), 39-1 Hawolgokdong, Seoul, 136-791, Korea. Electronic address: kimj@kist.re.kr.
authors.forename: Jinhyun
authors.initials: J
authors.lastname: Kim
mesh_terms: D000818:Animals; D001931:Brain Mapping; D016000:Cluster Analysis; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D018274:Electroporation; D006624:Hippocampus / Q000033:anatomy & histology / Q000166:cytology*; D021621:Imaging, Three-Dimensional; D066298:In Vitro Techniques; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D037121:Plant Lectins / Q000378:metabolism; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D013569:Synapses / Q000502:physiology*
chemical_list: D008164:Luminescent Proteins; D037121:Plant Lectins; C034981:tomato lectin