title: Neuroprotective Effects of a Butanol Fraction of Rosa hybrida Petals in a Middle Cerebral Artery Occlusion Model.
abstract: The neuroprotective effects of a butanol fraction of white rose petal extract (WRPE-BF) were investigated in a middle cerebral artery occlusion (MCAO) model. Seven week-old male rats were orally administered WRPE-BF for 2 weeks and subjected to MCAO for 2 h, followed by reperfusion. Twenty-four h later, MCAO-induced behavioral dysfunctions were markedly improved in a dose-dependent manner by pretreatment with WRPE-BF. Moreover, higher dose of WRPE-BF not only decreased infarction area but also effectively reduced astrogliosis. The expression of inducible nitric oxide synthase, cyclooxygenase-2, and glial fibrillary acidic protein in MCAO model were markedly inhibited by WRPE-BF treatment. Notably, WRPE-BF decreased nitric oxide and malondialdehyde levels in the striatum and subventricular zone of stroke-challenged brains. These data suggested that WRPE-BF may exert its neuroprotective effects via anti-oxidative and anti-inflammatory activities against ischemia-reperfusion brain injury and could be a good candidate as a therapeutic target for ischemic stroke.
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Goeun
authors.initials: G
authors.lastname: Yang
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Dongsun
authors.initials: D
authors.lastname: Park
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Lee
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Dae-Kwon
authors.initials: DK
authors.lastname: Bae
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Yang
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Jangbeen
authors.initials: J
authors.lastname: Kyung
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Dajeong
authors.initials: D
authors.lastname: Kim
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Ehn-Kyoung
authors.initials: EK
authors.lastname: Choi
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Jin Tae
authors.initials: JT
authors.lastname: Hong
authors.affiliation: Department Food Science and Technology, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Heon-Sang
authors.initials: HS
authors.lastname: Jeong
authors.affiliation: Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University, Gangneung 210- 702, Republic of Korea.
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Kim
authors.affiliation: Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University, Gangneung 210- 702, Republic of Korea.
authors.forename: Su Kil
authors.initials: SK
authors.lastname: Jang
authors.affiliation: Department of Marine Molecular Biotechnology, College of Life Science, Gangneung-Wonju National University, Gangneung 210- 702, Republic of Korea.
authors.forename: Seong Soo
authors.initials: SS
authors.lastname: Joo
authors.affiliation: College of Veterinary Medicine, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Yun-Bae
authors.initials: YB
authors.lastname: Kim
keywords: Anti-inflammation; Antioxidation; Glial fibrillary acidic protein; Ischemic brain injury; Middle cerebral artery occlusion; Rosa hybrida