title: Family-based association study between monoamine oxidase A (MAOA) gene promoter VNTR polymorphism and Tourette's syndrome in Chinese Han population.
abstract: To clarify the association of monoamine oxidase A- variable number of tandem repeat (MAOA-pVNTR) with susceptibility to Tourette's syndrome (TS) in Chinese Han population we discuss the genetic contribution of MAOA-VNTR in 141 TS patients including all their parents in Chinese Han population using transmission disequilibrium test (TDT) design. Our results revealed that no significant association was found in the MAOA gene promoter VNTR polymorphism and TS in Chinese Han population (TDT = 1.515, df = 1, p > 0.05). The negative result may be mainly due to the small sample size, but we don't deny the role of gene coding serotonergic or monoaminergic structures in the etiology of TS.
authors.affiliation: a Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College , Qingdao University , Qingdao 266003 , China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.forename: Xueqin
authors.initials: X
authors.lastname: Wang
authors.forename: Longqiang
authors.initials: L
authors.lastname: Xu
authors.forename: Lanlan
authors.initials: L
authors.lastname: Zheng
authors.forename: Yinlin
authors.initials: Y
authors.lastname: Ge
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D005190:Family; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats; D008995:Monoamine Oxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D005879:Tourette Syndrome / Q000235:genetics*
chemical_list: D008995:Monoamine Oxidase; C579458:monoamine oxidase A, human
keywords: MAOA; TDT; TS; VNTR