title: Canadian Society of Nephrology Commentary on the 2012 KDIGO clinical practice guideline for glomerulonephritis: management of glomerulonephritis in adults.
abstract: The KDIGO (Kidney Disease: Improving Global Outcomes) clinical practice guideline for management of glomerulonephritis was recently released. The Canadian Society of Nephrology convened a working group to review the recommendations and comment on their relevancy and applicability to the Canadian context. A subgroup of adult nephrologists reviewed the guideline statements for management of glomerular disease in adults and agreed with most of the guideline statements developed by KDIGO. This commentary highlights areas for which there is lack of evidence and areas in need of translation of evidence into clinical practice. Areas of controversy or uncertainty, including the choice of second-line agents, are discussed in more detail. Existing practice variation also is addressed. The relevance of treatment recommendations to the Canadian practitioner is discussed.
authors.affiliation: Department of Medicine, McGill University, Montreal, Quebec.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Cybulsky
authors.affiliation: Division of Nephrology, Department of Medicine, McMaster University, Hamilton.
authors.forename: Michael
authors.initials: M
authors.lastname: Walsh
authors.affiliation: Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa.
authors.forename: Greg
authors.initials: G
authors.lastname: Knoll
authors.affiliation: Department of Medicine, University of Toronto, Toronto, Ontario.
authors.forename: Michelle
authors.initials: M
authors.lastname: Hladunewich
authors.affiliation: Department of Medicine, University of Toronto, Toronto, Ontario.
authors.forename: Joanne
authors.initials: J
authors.lastname: Bargman
authors.affiliation: Department of Medicine, University of Toronto, Toronto, Ontario.
authors.forename: Heather
authors.initials: H
authors.lastname: Reich
authors.affiliation: Transplant Infectious Diseases, University of Alberta, Edmonton, Alberta.
authors.forename: Atul
authors.initials: A
authors.lastname: Humar
authors.affiliation: Department of Pediatrics, University of Alberta, Edmonton, Alberta.
authors.forename: Susan
authors.initials: S
authors.lastname: Samuel
authors.affiliation: Montreal Children's Hospital, Montreal, Quebec.
authors.forename: Martin
authors.initials: M
authors.lastname: Bitzan
authors.affiliation: Montreal Children's Hospital, Montreal, Quebec.
authors.forename: Michael
authors.initials: M
authors.lastname: Zappitelli
authors.affiliation: Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba.
authors.forename: Allison
authors.initials: A
authors.lastname: Dart
authors.affiliation: Department of Pediatrics, University of British Columbia, Vancouver, British Columbia.
authors.forename: Cherry
authors.initials: C
authors.lastname: Mammen
authors.affiliation: Department of Pediatrics, University of Alberta, Edmonton, Alberta.
authors.forename: Maury
authors.initials: M
authors.lastname: Pinsk
authors.affiliation: Division of Nephrology, Department of Medicine, Western University, London, Ontario, Canada. Electronic address: norman.muirhead@lhsc.on.ca.
authors.forename: Norman
authors.initials: N
authors.lastname: Muirhead
mesh_terms: D000328:Adult; D002170:Canada; D019468:Disease Management; D005921:Glomerulonephritis / Q000628:therapy*; D006801:Humans; D009398:Nephrology; D017410:Practice Guidelines as Topic; D012955:Societies, Medical
keywords: Canadian Society of Nephrology (CSN); Clinical practice guideline implementation; KDIGO (Kidney Disease: Improving Global Outcomes); glomerulonephritis; nephrotic syndrome