title: Promising antimicrobial capability of thin film metallic glasses.
abstract: Thin film metallic glasses (TFMGs) are demonstrated to exhibit excellent surface flatness, high corrosion resistance and satisfactory hydrophobic properties. Moreover, the antimicrobial and biocompatibility abilities of TFMGs are examined and the results are compared with the behavior of pure Ag and 316L stainless steel. Three TFMGs, Al48Ag37Ti15, Zr54Ti35Si11, and Zr59Ti22Ag19, are prepared by sputtering to assess the antimicrobial performance against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, which are the most common nosocomial infection pathogens. Experimental results show that the antimicrobial effect of the Al- or Ag-containing AlAgTi and ZrTiAg TFMGs is similar to that of the pure Ag coating. The ZrTiSi TFMG with no Ag or Al shows poor antimicrobial capability. The physical properties of highly smooth surface and hydrophobic nature alone are not sufficient to result in promising antimicrobial ability. The chemical metal ion release still plays a major role, which should be born in mind in designing biomedical devices.
authors.affiliation: Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, ROC.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Chu
authors.affiliation: Departments of Orthopedics and Orthopedic Research Center in College of Medicine, Taiwan, ROC; Department of Orthopedics in Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
authors.forename: Y S
authors.initials: YS
authors.lastname: Lin
authors.affiliation: Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, ROC.
authors.forename: C M
authors.initials: CM
authors.lastname: Chang
authors.affiliation: Department of Biological Science, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, ROC.
authors.forename: J-K
authors.initials: JK
authors.lastname: Liu
authors.affiliation: Departments of Orthopedics and Orthopedic Research Center in College of Medicine, Taiwan, ROC; Department of Orthopedics in Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
authors.affiliation: Department of Materials and Optoelectronic Science, National Sun Yat-Sen University, Kaohsiung 804, Taiwan, ROC. Electronic address: jacobc@mail.nsysu.edu.tw.
authors.forename: J C
authors.initials: JC
authors.lastname: Huang
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005898:Glass / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000187:drug effects; D008670:Metals / Q000494:pharmacology*; D051379:Mice; D008826:Microbial Sensitivity Tests; D018625:Microscopy, Atomic Force; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D020099:Coated Materials, Biocompatible; D008670:Metals
keywords: Antimicrobial effect; Metallic glass; Silver; Thin film