title: Muscle changes in aging: understanding sarcopenia.
abstract: Muscle physiology in the aging athlete is complex. Sarcopenia, the age-related decrease in lean muscle mass, can alter activity level and affect quality of life. This review addresses the microscopic and macroscopic changes in muscle with age, recognizes contributing factors including nutrition and changes in hormone levels, and identifies potential pharmacologic agents in clinical trial that may aid in the battle of this complex, costly, and disabling problem.
  
  
  METHODS
  Level 5.
authors.affiliation: Sports Medicine Section, Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: Patrick N
authors.initials: PN
authors.lastname: Siparsky
authors.affiliation: Sports Medicine Section, Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina ; Center for Learning Health Care, Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina.
authors.forename: Donald T
authors.initials: DT
authors.lastname: Kirkendall
authors.affiliation: Sports Medicine Section, Department of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina.
authors.forename: William E
authors.initials: WE
authors.lastname: Garrett
keywords: SARMs; aging athlete; muscle aging; sarcopenia