title: Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation of (Z)-α-santalol.
abstract: Biocatalyst mediated regio- and stereo-selective hydroxylation and epoxidation on (Z)-α-santalol were achieved for the first time, using a fungal strain Mucor piriformis. Four novel metabolites were characterized as 10,11-cis-β-epoxy-α-santalol, 5α-hydroxy-(Z)-α-santalol, 10,11-dihydroxy-α-santalol and 5α-hydroxy-10,11-cis-β-epoxy-α-santalol. Using Amano PS lipase from Burkholderia cepacia, α- and β-isomers of 10,11-cis-epoxy-α-santalol were resolved efficiently.
authors.affiliation: Chemical Biology Unit, Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India. hv.thulasiram@ncl.res.in.
authors.forename: Pankaj P
authors.initials: PP
authors.lastname: Daramwar
authors.forename: Prabhakar Lal
authors.initials: PL
authors.lastname: Srivastava
authors.forename: Swati P
authors.initials: SP
authors.lastname: Kolet
authors.forename: Hirekodathakallu V
authors.initials: HV
authors.lastname: Thulasiram
mesh_terms: D055162:Biocatalysis; D016956:Burkholderia cepacia / Q000201:enzymology; D006900:Hydroxylation; D008049:Lipase / Q000378:metabolism*; D008968:Molecular Conformation; D009089:Mucor / Q000378:metabolism*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000378:metabolism*; D013237:Stereoisomerism
chemical_list: D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C043206:santalol; D008049:Lipase