title: Diffuse skeletal muscle metastases from sacral chordoma.
abstract: Chordomas are rare, slow-growing tumors arising from cellular remnants of the notochord. They account for 1-4% of primary malignant bone tumors and usually occur in the axial skeleton, most commonly the sacrum. Although typically locally recurrent, chordoma metastasis rates as high as 10-42% have been reported. While spread to multiple organ systems has been documented, metastatic disease to skeletal muscle is extremely rare. We present a case of extensive, multifocal skeletal muscle metastases developing in the setting of recurrent sacral chordoma. Our literature search found only one additional case of metastatic chordoma to a single skeletal muscle.
authors.affiliation: Department of Radiology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Carey
authors.forename: Joseph
authors.initials: J
authors.lastname: Bestic
authors.forename: Steven
authors.initials: S
authors.lastname: Attia
authors.forename: Cherise
authors.initials: C
authors.lastname: Cortese
authors.forename: Manoj
authors.initials: M
authors.lastname: Jain
mesh_terms: D000368:Aged; D002817:Chordoma / Q000175:diagnosis* / Q000556:secondary*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D019042:Muscle Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000473:pathology; D011877:Radionuclide Imaging; D012447:Sacrum / Q000000981:diagnostic imaging* / Q000473:pathology*