title: Neurocognitive dysfunction and regional cerebral blood flow in medically naïve patients with obsessive-compulsive disorder.
abstract: Previous research characterizes obsessive compulsive disorder (OCD) as a complex neurobehavioral disorder that may have multiple etiologies ( den Braber et al., 2008 ). This study analyzed neurocognitive function and change in regional cerebral blood flow (rCBF) to characterize OCD. Neurocognitive function and rCBF were examined in medically naïve patients with OCD and contrasted with controls. Results of this study indicated that the neurocognitive functions impaired in OCD are memory, attention, and executive function, which are primarily associated with the frontal and occipital lobes. Dysfunction in the basal ganglia and occipital lobes were associated with OCD and may be an etiological factor in the disorder.
authors.affiliation: a Department of Psychology, Third Affiliated Hospital , Sun Yat-sen University , Guangzhou , China.
authors.forename: Sheng-lin
authors.initials: SL
authors.lastname: Wen
authors.forename: Min-feng
authors.initials: MF
authors.lastname: Cheng
authors.forename: Mu-hua
authors.initials: MH
authors.lastname: Cheng
authors.forename: Ji-hui
authors.initials: JH
authors.lastname: Yue
authors.forename: Jian-fang
authors.initials: JF
authors.lastname: Li
authors.forename: Liang-jun
authors.initials: LJ
authors.lastname: Xie
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003072:Cognition Disorders / Q000473:pathology / Q000503:physiopathology*; D004569:Electroencephalography; D056344:Executive Function / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology; D009771:Obsessive-Compulsive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed