title: Does selenium matter in cardiometabolic disorders? A short review of the evidence.
abstract: Selenium is an essential micronutrient in the human diet. It is a constituent of selenoproteins, linked to cysteine, and is involved in the defense against oxidative stress. Few studies suggested a role of selenoproteins in the prevention of chronic degenerative disorders, including Parkinson's and Alzheimer disease, cancer, cardiovascular disease, atherosclerosis, stroke, and infertility. On the other hand, concerns were raised about a possible association of selenium supplementation with increased risk of developing insulin resistance and Type 2 diabetes. The objective of this article is to briefly review the results of the observational (cohort and case-control) studies as well as of the randomized controlled trials of selenium supplementation and risk of metabolic and cardiovascular disorders.
authors.affiliation: Department of Clinical Medicine and Surgery, ESH Excellence Center of Hypertension, Federico II University of Naples Medical School, Naples, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Sabino
authors.forename: S
authors.initials: S
authors.lastname: Stranges
authors.forename: P
authors.initials: P
authors.lastname: Strazzullo