title: An attempt to construct a (general) mathematical framework to model biological "context-dependence".
abstract: Context-dependent nature of biological phenomena is well documented in every branch of biology. While there have been few previous attempts to (implicitly) model various (particular) facets of biological context-dependence, a formal and general mathematical construct to model the wide spectrum of context-dependence, eludes the students of biology. Such an objective model, from both 'bottom-up' as well as 'top-down' perspective, is proposed here to serve as the template to describe the various kinds of context-dependence that we encounter in different branches of biology. Interactions between biological contexts was found to be transitive but non-commutative. It is found that a hierarchical nature of dependence among the biological contexts models the emergent biological properties efficiently. Reasons for these findings are provided in a general model to describe biological reality. Scheme to algorithmically implement the hierarchic structure of organization of biological contexts was proposed with a construct named 'Context tree'. A 'Context tree' based analysis of context interactions among biophysical factors influencing protein structure was performed.
authors.affiliation: Bioinformatics Centre, University of Pune, Pune, 411007 Maharashtra India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Banerji
keywords: Biological contexts; Context tree; Emergence; Hierarchical organization; Mathematical model; Protein structure; Structural dependencies; Thread-mesh model