title: Potential health impact and genotoxicity analysis of drinking source water from Liuxihe Reservoir (P.R. China).
abstract: Water from the Liuxihe Reservoir (a source of drinking water for Guangzhou City, P. R. China) was analyzed for semi-volatile organic compounds (SVOCs) and the results were used for a potential health impact assessment and genotoxicity test with the microalgae Euglena gracilis. The SVOCs were tested using USEPA Method 525.2, and the health risk assessment was conducted at a screening level using the hazard quotient (HQ) approach. Alkaline single-cell gel electrophoresis (comet assay) was used to evaluate DNA damage and determine the genotoxicity of the source water. The concentrations of the SVOCs in Liuxihe Reservoir were very low and phthalic acid esters were the main SVOCs present. The mean HQ values of pollutants were all less than one, indicating no risk. However, the lifetime carcinogenic risks (LCRs) were found to be close to the threshold of 1.00E-5. The results show that the water in the Liuxihe Reservoir might pose a potential carcinogenic risk to local residents. The highly concentrated extracts of the water samples could induce DNA damage in the microalgal cells and a dose-effect relationship was identified. These results showed that Liuxihe Reservoir water, as a source of drinking water, could pose a potential LCR to local consumers.
authors.affiliation: State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Xianlin Campus, 163 Xianlin Avenue, Nanjing, 210023, China.
authors.forename: Weili
authors.initials: W
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Li
authors.forename: Yibin
authors.initials: Y
authors.lastname: Cui
authors.forename: Xiangyu
authors.initials: X
authors.lastname: Gao
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Qian
mesh_terms: D002681:China; D020552:Comet Assay; D005056:Euglena gracilis; D006801:Humans; D018570:Risk Assessment; D055549:Volatile Organic Compounds / Q000032:analysis / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*; D014881:Water Supply
chemical_list: D055549:Volatile Organic Compounds; D014874:Water Pollutants, Chemical