title: Preparation, characterization, and antibacterial activity studies of silver-loaded poly(styrene-co-acrylic acid) nanocomposites.
abstract: A simple method for preparing a new type of stable antibacterial agent was presented. Monodisperse poly(styrene-co-acrylic acid) (PSA) nanospheres, serving as matrices, were synthesized via soap-free emulsion polymerization. Field-emission scanning electron microscopy micrographs indicated that PSA nanospheres have interesting surface microstructures and well-controlled particle size distributions. Silver-loaded poly(styrene-co-acrylic acid) (PSA/Ag-NPs) nanocomposites were prepared in situ through interfacial reduction of silver nitrate with sodium borohydride, and further characterized by transmission electron microscopy and X-ray diffraction. Their effects on antibacterial activity including inhibition zone, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and bactericidal kinetics were evaluated. In the tests, PSA/Ag-NPs nanocomposites showed excellent antibacterial activity against both gram-positive Staphylococcus aureus and gram-negative Escherichia coli. These nanocomposites are considered to have potential application in antibacterial coatings on biomedical devices to reduce nosocomial infection rates.
authors.affiliation: Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China; Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
authors.forename: Cunfeng
authors.initials: C
authors.lastname: Song
authors.affiliation: Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chang
authors.affiliation: Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Yiting
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Endodontics, Xiamen Stomatology Hospital, Teaching Hospital of Fujian Medical University, Xiamen 361003, China. Electronic address: tinachen0628@163.com.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Long
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China.
authors.forename: Lina
authors.initials: L
authors.lastname: Zhong
authors.affiliation: Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China. Electronic address: lzdai@xmu.edu.cn.
authors.forename: Lizong
authors.initials: L
authors.lastname: Dai
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D057446:Hydrodynamics; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D054118:Nanospheres / Q000648:ultrastructure; D010316:Particle Size; D011137:Polystyrenes / Q000737:chemistry*; D012834:Silver / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000179:Acrylates; D000900:Anti-Bacterial Agents; D011137:Polystyrenes; C509855:poly(styrene-b-acrylic acid); D012834:Silver
keywords: Antibacterial agent; Nanocomposites; Silver; Soap-free emulsion polymerization