title: [Preparation of and study on magnetic resonance imaging performance of metal porphyrin modified by low molecular weight chitosan].
abstract: The functional complex Mn-TCPP-CS20 as a potential magnetic resonance imaging (MRI) contrast agent was synthesized through tetra(4-carboxyphenyl) Mn(II)-porphyrin (Mn-TCPP) modified by CS20, which was low degree of polymerization and narrow distribution. The results showed that Mn-TCPP-CS20 had good water-solubility and structural stability. The chemical structures of the products were characterized with Fourier transform infrared spectra (FTIR), UV-Vis spectra, mass spectrum (MS) and inductively coupled plasma atomic emission spectrometry (ICP-AES). The results showed that Mn-TCPP was successfully linked to CS20 by an amide function. The relaxation properties in vitro of the functional complex Mn-TCPP-CS20 as the potential MRI contrast agent were preliminarily studied. It was found that the longitudinal relaxivity (r1) of the synthesized Mn-TCPP-CS20 (6.11 mmol(-1) x L x s(-1)) was higher than that of the commercial contrast agent Gd-DTPA (r1 = 3.59 mmol(-1) x L x s(-1)). Besides, the imaging effect of Mn-TCPP-CS20 was superior to that of Gd-DTPA in the same condition. These studies suggested that Mn-TCPP-CS20 has the advantage of becoming a potential tissue-targeting contrast agent.
authors.affiliation: Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China. ujstrunks@126.com
authors.forename: Dong-Jun
authors.initials: DJ
authors.lastname: Yu
authors.affiliation: Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
authors.forename: Min-Zhi
authors.initials: MZ
authors.lastname: Li
authors.affiliation: Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
authors.forename: Xian-Zhu
authors.initials: XZ
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Zhu
authors.affiliation: Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.affiliation: Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.affiliation: Department of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D003287:Contrast Media / Q000737:chemistry; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D008665:Metalloporphyrins / Q000737:chemistry*; D008970:Molecular Weight
chemical_list: D003287:Contrast Media; D008665:Metalloporphyrins; C474139:manganese(III)-tetra(4-carboxyphenyl)porphine; D048271:Chitosan; D019786:Gadolinium DTPA