title: Time course of brain volume changes in the preclinical phase of Alzheimer's disease.
abstract: BACKGROUND
  Structural alterations of a large network characterize Alzheimer's disease (AD), but the time course of these changes remains unclear. The dynamic of these alterations was examined in the AD preclinical phase using data from the 10-year follow-up of a population-based cohort (Bordeaux-3City).
  
  
  METHODS
  Participants received neuropsychological assessments every 2 years and two identical magnetic resonance imaging (MRI) exams at baseline and 4 years later. Twenty-five incident AD cases were compared with 319 subjects who remained free of dementia. Subjects were free of dementia at baseline and at follow-up MRI. Incident AD occurred after these time points.
  
  
  RESULTS
  At baseline, incident AD already presented smaller volumes only in the left amygdalo-hippocampal complex. Moreover, a higher annual rate of atrophy of the temporoparietal cortices was observed in future AD subjects during the following 4 years.
  
  
  CONCLUSIONS
  Incident AD cases present mediotemporal lesions up to 5 years before diagnosis. This neurodegenerative process seems to progressively reach the temporoparietal cortices in the AD preclinical phase.
authors.affiliation: University of Bordeaux, INCIA, Talence, France; CNRS, INCIA, Talence, France; EPHE, Bordeaux, France. Electronic address: charlotte.bernard1@yahoo.fr.
authors.forename: Charlotte
authors.initials: C
authors.lastname: Bernard
authors.affiliation: INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France; INSERM, Clinical Investigation Center-Clinical Epidemiology 7, Bordeaux, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Helmer
authors.affiliation: University of Bordeaux, INCIA, Talence, France; CNRS, INCIA, Talence, France.
authors.forename: Bixente
authors.initials: B
authors.lastname: Dilharreguy
authors.affiliation: INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Amieva
authors.affiliation: INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France; University Hospital, Memory Consultation, CMRR, Bordeaux, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Auriacombe
authors.affiliation: INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; University of Bordeaux, Bordeaux, France; University Hospital, Memory Consultation, CMRR, Bordeaux, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Dartigues
authors.affiliation: University of Bordeaux, INCIA, Talence, France; CNRS, INCIA, Talence, France; EPHE, Bordeaux, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Allard
authors.affiliation: University of Bordeaux, INCIA, Talence, France; CNRS, INCIA, Talence, France; EPHE, Bordeaux, France.
authors.forename: Gwénaëlle
authors.initials: G
authors.lastname: Catheline
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology*; D000704:Analysis of Variance; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D013997:Time Factors
keywords: Alzheimer disease; Longitudinal; Magnetic resonance imaging; Medial temporal lobe; Preclinical phase; Voxel-based morphometry