title: The interaction between mother and fetus and the development of allergic asthma.
abstract: The rising prevalence of asthma and atopic disease in industrialized countries in the last 50 years has raised important questions about how and why the disease develops in susceptible populations. Most asthma begins in childhood in association with allergic sensitization and the development of a TH2 phenotype. It is recognized that asthma arises in the context of a complex interaction between genetic factors and the evolving immune system of the infant and the environment to which it is exposed, which now includes its in utero exposure. Early life exposures that lead to allergen sensitization and airway damage, especially in the form of viral respiratory tract infections, may lead to disease induction that commence the process that leads in some to asthma. Asthma models and early life observations suggest that repeated exposure to allergens and viral infection perpetuate a state of chronic airway inflammation leading to a maladaptive innate immune response that fails to resolve, characterized by chronic airway inflammation, airway remodeling and airway hyperresponsiveness. This article will concentrate on the development of asthma in the context of early life and maternal influences, including the effect of asthma on both the fetus and the mother.
authors.affiliation: Hunter Medical Research Institute and The University of Newcastle, Priority Research Centre for Asthma and Respiratory Diseases, Newcastle, New South Wales, Australia.
authors.forename: Peter A B
authors.initials: PA
authors.lastname: Wark
authors.forename: Vanessa
authors.initials: V
authors.lastname: Murphy
authors.forename: Joerg
authors.initials: J
authors.lastname: Mattes
mesh_terms: D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000276:immunology* / Q000503:physiopathology; D003713:Dendritic Cells / Q000473:pathology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000503:physiopathology; D007113:Immunity, Innate / Q000276:immunology / Q000502:physiology; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D011247:Pregnancy; D018418:Th2 Cells / Q000473:pathology
chemical_list: D000485:Allergens