title: A Fas-associated via death domain promoter polymorphism (rs10898853, -16C/T) as a risk factor for papillary thyroid cancer.
abstract: OBJECTIVE
  To determine whether a Fas-associated via death domain (FADD) promoter single-nucleotide polymorphism (SNP) is associated with susceptibility to papillary thyroid cancer (PTC) and clinicopathological features of PTC.
  
  
  METHODS
  To identify a possible association with PTC, 94 patients with PTC and 346 healthy controls were recruited. One promoter SNP (rs10898853, -16C/T) was analyzed by direct sequencing. Multiple logistic regression models (co-dominant, dominant, recessive, and log-additive models) were applied, and odds ratios (ORs), 95% confidence intervals (CIs), and p values were calculated.
  
  
  RESULTS
  The genotype of the promoter SNP (rs10898853) of FADD was found to be significantly associated with PTC in the co-dominant model 2 (T/T vs. C/C; p = 0.002, OR = 2.80, 95% CI = 1.39-5.65), the recessive model (p = 0.003, OR = 2.21, 95% CI = 1.31-3.71), and the log-additive model (p = 0.002, OR = 1.71, 95% CI = 1.20-2.44). Allele frequency analysis showed that the C allele of rs10898853 was significantly associated with an increased risk of PTC (p = 0.002, OR = 1.67, 95% CI = 1.21-2.32).
  
  
  CONCLUSIONS
  Our results suggest that the FADD promoter polymorphism is associated with susceptibility to PTC.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, South Korea.
authors.forename: Y G
authors.initials: YG
authors.lastname: Eun
authors.forename: D H
authors.initials: DH
authors.lastname: Chung
authors.forename: S W
authors.initials: SW
authors.lastname: Kim
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.forename: S K
authors.initials: SK
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Kwon
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D002277:Carcinoma / Q000235:genetics*; D002291:Carcinoma, Papillary / Q000235:genetics*; D016022:Case-Control Studies; D053200:Fas-Associated Death Domain Protein / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D056910:Republic of Korea; D012307:Risk Factors; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: C505533:FADD protein, human; D053200:Fas-Associated Death Domain Protein