title: [Formation of oxalate in oxaliplatin injection diluted with infusion solutions].
abstract: Oxaliplatin use can cause acute peripheral neuropathy characterized by sensory paresthesias, which are markedly exacerbated by exposure to cold temperatures, and is a dose-limiting factor in the treatment of colorectal cancer.Oxalate is eliminated in a series of nonenzymatic conversions of oxaliplatin in infusion solutions or biological fluids.Elimination of oxalate from oxaliplatin has been suggested as one of the reasons for the development of acute neuropathy.In this study, we developed a high-performance liquid chromatography(HPLC)-based method to detect oxalate formation, and investigated the time dependent formation of oxalate in oxaliplatin diluted with infusion solutions.The results obtained showed that the amount of oxalate in the solution corresponded to 1.6% of oxaliplatin 8 h after oxaliplatin dilution with a 5% glucose solution. On the other hand, oxalate formation from oxaliplatin diluted with a saline solution was ten-fold higher than that from oxaliplatin diluted with the 5% glucose solution.Most patients who were intravenously injected with oxaliplatin experienced venous pain.As a preventive measure against venous pain, dexamethasone was added to the oxaliplatin injection.We measured the amount of oxalate formed in the dexamethasone-containing oxaliplatin injection diluted with a 5% glucose solution.The amount of oxalate formed when dexamethasone was added did not differ significantly from that formed when dexamethasone was not added.Thus, there are no clinical problems associated with the stability of oxaliplatin solutions.
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University.
authors.forename: Seiji
authors.initials: S
authors.lastname: Eto
authors.forename: Kie
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Kounosuke
authors.initials: K
authors.lastname: Shimazu
authors.forename: Toshimune
authors.initials: T
authors.lastname: Sugiura
authors.forename: Kaori
authors.initials: K
authors.lastname: Baba
authors.forename: Ayaka
authors.initials: A
authors.lastname: Sato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Goromaru
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hagiwara
authors.forename: Keiko
authors.initials: K
authors.lastname: Hara
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Shinohara
authors.forename: Kojiro
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010070:Oxalates / Q000737:chemistry*; D000077150:Oxaliplatin; D019999:Pharmaceutical Solutions / Q000737:chemistry; D012996:Solutions / Q000737:chemistry
chemical_list: D009944:Organoplatinum Compounds; D010070:Oxalates; D019999:Pharmaceutical Solutions; D012996:Solutions; D000077150:Oxaliplatin