title: Immunomodulatory nature and site specific affinity of mesenchymal stem cells: a hope in cell therapy.
abstract: Immunosuppressive ability of mesenchymal stem cells (MSCs), their differentiation properties to various specialized tissue types, ease of in vitro and in vivo expansion and specific migration capacity, make them to be tested in different clinical trials for the treatment of various diseases. The immunomodulatory effects of MSCs are less identified which probably has high clinically significance. The clinical trials based on primary research will cause better understanding the ability of MSCs in immunomodulatory applications and site specific migration in the optimization of therapy. So, this review focus on MSCs functional role in modulating immune responses, their ability in homing to tumor, their potency as delivery vehicle and their medical importance.
authors.affiliation: Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Parisa
authors.initials: P
authors.lastname: Lotfinegad
authors.affiliation: Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tabriz, Iran.
authors.forename: Karim
authors.initials: K
authors.lastname: Shamsasenjan
authors.affiliation: Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Movassaghpour
authors.affiliation: Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Jafar
authors.initials: J
authors.lastname: Majidi
authors.affiliation: Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Behzad
authors.initials: B
authors.lastname: Baradaran
keywords: Cell migration; Cell therapy; Immunomodulation; Mesenchymal stem cells