title: Toward a rational design of surface textures promoting endothelialization.
abstract: The safe integration of cardiovascular devices requires the sustainable coverage of their luminal surface by endothelial cells (ECs). The engineering of active surface textures has the potential to coordinate cellular adhesion and migration under the action of hemodynamic forces. We define a paradigm to rationally design textures maximizing EC activities as a function of the applied stresses. This is based on harnessing the adhesions established by ECs through fine-tuning of the vertical extend of the underlying surface nanotopography.
authors.affiliation: Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH Zurich , Sonneggstrasse 3, CH-8092 Zurich, Switzerland.
authors.forename: Eva
authors.initials: E
authors.lastname: Potthoff
authors.forename: Davide
authors.initials: D
authors.lastname: Franco
authors.forename: Valentina
authors.initials: V
authors.lastname: D'Alessandro
authors.forename: Christoph
authors.initials: C
authors.lastname: Starck
authors.forename: Volkmar
authors.initials: V
authors.lastname: Falk
authors.forename: Tomaso
authors.initials: T
authors.lastname: Zambelli
authors.forename: Julia A
authors.initials: JA
authors.lastname: Vorholt
authors.forename: Dimos
authors.initials: D
authors.lastname: Poulikakos
authors.forename: Aldo
authors.initials: A
authors.lastname: Ferrari
mesh_terms: D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D013314:Stress, Mechanical; D013499:Surface Properties