title: Hand, foot and mouth disease in Guangdong, China, in 2013: new trends in the continuing epidemic.
abstract: Millions of incidents of hand, foot and mouth disease occur annually in China, with EVA71 and CVA16 as two major causative pathogens. A provincial surveillance system has been implemented in Guangdong for almost 5 years to analyze the aetiological spectrum and epidemic changes. An unusual enterovirus type, CVA6, was identified as the predominant serotype associated with an HFMD epidemic from late 2012 to 2013. In contrast to virus strains isolated before, all CVA6/CHN/2012-2013 strains segregated into one major genetic cluster. This study suggested that one cluster of circulating CVA6 strain had emerged as a new and major cause during a continuing HFMD epidemic in Guangdong, China.
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China; Guangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
authors.forename: J
authors.initials: J
authors.lastname: Lu
authors.forename: H
authors.initials: H
authors.lastname: Zeng
authors.forename: H
authors.initials: H
authors.lastname: Zheng
authors.forename: L
authors.initials: L
authors.lastname: Yi
authors.forename: X
authors.initials: X
authors.lastname: Guo
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: L
authors.initials: L
authors.lastname: Sun
authors.forename: X
authors.initials: X
authors.lastname: Tan
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Ke
authors.forename: J
authors.initials: J
authors.lastname: Lin
mesh_terms: D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D004770:Enterovirus / Q000145:classification / Q000302:isolation & purification*; D005838:Genotype; D006232:Hand, Foot and Mouth Disease / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D017720:Molecular Epidemiology; D065288:Serogroup
keywords: Coxsackievirus A6; enterovirus; foot and mouth disease; hand; molecular epidemiology; phylogenetic analyses