title: Effects of continuous ingestion of hesperidin and glucosyl hesperidin on vascular gene expression in spontaneously hypertensive rats.
abstract: Hesperidin (HES) and glucosyl hesperidin (GHES) have antihypertensive effects. In the present study, to clarify the antihypertensive mechanisms, we compared the effects of continuous ingestion of HES and GHES in spontaneously hypertensive rats (SHRs). HES and GHES ingestion for 8 wk significantly prevented hypertension and suppressed the mRNA expression of NADPH oxidase subunits and thromboxane A2 synthase in SHR aortas. Further, hesperetin, a common metabolite of HES and GHES, reduced thromboxane B2 release from SHR aortas. These findings indicate that continuous ingestion of HES and GHES prevents hypertension via regulating the gene expression related to the modulation of vascular tone.
authors.affiliation: Biological Science Laboratories, Kao Corporation.
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Hiroko
authors.initials: H
authors.lastname: Jokura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Suzuki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hase
authors.forename: Akira
authors.initials: A
authors.lastname: Shimotoyodome
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D001013:Aorta, Thoracic / Q000201:enzymology* / Q000378:metabolism; D019587:Dietary Supplements / Q000009:adverse effects; D004730:Endothelium, Vascular / Q000201:enzymology* / Q000378:metabolism; D004794:Enzyme Repression; D005960:Glucosides / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D006569:Hesperidin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D006973:Hypertension / Q000378:metabolism / Q000517:prevention & control*; D066298:In Vitro Techniques; D008297:Male; D019255:NADPH Oxidases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D021122:Protein Subunits / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D012995:Solubility; D013929:Thromboxane B2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D014655:Vascular Resistance
chemical_list: D000959:Antihypertensive Agents; D005960:Glucosides; D021122:Protein Subunits; C487382:glucosyl hesperidin; D013929:Thromboxane B2; D006569:Hesperidin; D019255:NADPH Oxidases; D013930:Thromboxane-A Synthase; C013015:hesperetin