title: Crossing barriers; restoring barriers? Filaggrin protein replacement takes a bow.
abstract: In this issue of the Journal, Stout and colleagues report a novel and creative approach to replacement of genetically determined absence or deficiency of epidermal proteins. While these early data are certainly interesting, further validation work is required to determine the utility of this approach in genodermatoses.
authors.affiliation: Department of Paediatric Dermatology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Dublin, Ireland; Clinical Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address: irvinea@tcd.ie.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Irvine
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000628:therapy*; D000091344:Filaggrin Proteins; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007381:Intermediate Filament Proteins / Q000235:genetics* / Q000493:pharmacokinetics*
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins