title: Redox regulation of Janus kinase: The elephant in the room.
abstract: The redox regulation of Janus kinases (JAKs) is a complex subject. Due to other redox-sensitive kinases in the kinome, redox-sensitive phosphatases, and cellular antioxidant systems and reactive oxygen species (ROS) production systems, the net biological outcomes of oxidative stress on JAK-dependent signal transduction vary according to the specific biological system examined. This review begins with a discussion of the biochemical evidence for a cysteine-based redox switch in the catalytic domain of JAKs, proceeds to consider direct and indirect regulatory mechanisms involved in biological experiments, and ends with a discussion of the role(s) of redox regulation of JAKs in various diseases.
authors.affiliation: Department of Pharmacology and Toxicology and Department of Radiation Oncology; University of Mississippi Medical Center; Jackson, MS USA.
authors.forename: Roy J
authors.initials: RJ
authors.lastname: Duhé
keywords: Janus kinases; cysteine modification; cytokine biology; oxidative stress; redox regulation; thiol chemistry