title: Factors associated with early platelet activation in obese children.
abstract: OBJECTIVE
  To investigate the factors associated with platelet activation in obese children.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Department of Pediatrics of Regional Hospital N∘ 1 of Mexican Institute of Social Security in Morelia, Michoacán, Mexico.
  
  
  METHODS
  79 obese and 64 non-obese children between the ages of 5 and 10 years.
  
  
  METHODS
  Obese children (body mass index [BMI] >85 in growth curves for Centers for Disease Control/National Center for Health Statistics), and the control group of 64 non-obese children (percentile <85), % body fat, platelet activation was assessed by sP-selectin. Other measures were leptin, uric acid (UA), von Willebrand Factor (vWF), plasminogen activator inhibitor (PAI-1), lipid profile, and glucose.
  
  
  RESULTS
  Obese children displayed higher plasma sP-selectin, leptin, PAI-1, and vWF than non-obese children. In the univariate logistic regression analysis, leptin, vWF, UA, and high density lipoprotein (HDL), but not with PAI-1, were factors associated with platelet activation. By stepwise linear regression analysis adjusted by sex and age, the best predictor variables for platelet activation were leptin (β:0.381; t:4.665; P=0.0001), vWF (β:0.211; t:2.926; P=0.004), UA (β:0.166; t:2.146; P=0.034), and HDL (β:-0.215; t:-2.819; P=0.006).
  
  
  CONCLUSIONS
  Obese children have a higher risk of developing early platelet activation. Factors associated with platelet activation were Leptin, vWF, UA, and HDL. Further studies involving larger numbers of patients over a longer duration are needed to understand the possible molecular mechanism underlying the association between leptin, vWF, and UA and endothelial activation and/or endothelial damage/dysfunction in obese children and its influence in cardiovascular disease in adults.
authors.affiliation: Biomedical Research Center of Michoacán, Mexican Institute of Social Security, Morelia, Michoacán, México. anel_gomez04@yahoo.com.mx anel.gomez@imss.gob.mx.
authors.forename: Anel
authors.initials: A
authors.lastname: Gómez García
authors.affiliation: Department of Pediatrics, Mexican Institute of Social Security, Morelia, Michoacán, Mexico.
authors.forename: Guillermina García
authors.initials: GG
authors.lastname: Núñez
authors.affiliation: Postgrade of Medicine Faculty "Dr Ignacio Chávez" Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, Mexico.
authors.forename: Martha Eva Viveros
authors.initials: ME
authors.lastname: Sandoval
authors.affiliation: Regional General Hospital N∘1, Mexican Institute of Social Security, Morelia, Michoacán, Mexico.
authors.forename: Sergio Gutierrez
authors.initials: SG
authors.lastname: Castellanos
authors.affiliation: Regional General Hospital N∘1, Mexican Institute of Social Security, Morelia, Michoacán, Mexico.
authors.forename: Cleto
authors.initials: C
authors.lastname: Alvarez Aguilar
mesh_terms: D001786:Blood Glucose; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D016015:Logistic Models; D008297:Male; D019007:P-Selectin / Q000097:blood*; D063766:Pediatric Obesity / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D015539:Platelet Activation; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D020738:Leptin; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D019007:P-Selectin; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D014280:Triglycerides; D014841:von Willebrand Factor; D014527:Uric Acid; D002784:Cholesterol
keywords: Children; Endothelial activation; Leptin; Obesity; Uric acid