title: Interference-free acquisition of overlapping sequences in explicit spatial memory.
abstract: Some types of human sequential memory, e.g. the acquisition of a new composition by a trained musician, seem to be very efficient in extending the length of a memorized sequence and in flexible reuse of known subsequences in a newly acquired sequential context. This implies that interference between known and newly acquired subsequences can be avoided even when learning a sequence which is a partial mutation of a known sequence. It is known that established motor sequences do not have such flexibility. Using learning of deferred imitation, the current study investigates the flexibility of explicit spatial memory by quantifying the interferences between successively acquired, partially overlapping sequences. After learning a spatial sequence on day 1, this sequence was progressively modified on day 2. On day 3, a retention test was performed with both the initial and the modified sequence. The results show that subjects performed very well on day 1 and day 2. No spatial interference between changed and unchanged targets was observed during the stepwise progressive modification of the reproduced sequence. Surprisingly, subjects performed well on both sequences on day 3. Comparison with a control experiment without intermediate mutation training showed that the initial training on day 1 did not proactively interfere with the retention of the modified sequence on day 3. Vice versa, the mutation training on day 2 did not interfere retroactively with the retention of the original sequence as tested on day 3. The results underline the flexibility in acquiring explicit spatial memory.
authors.affiliation: Department of Neurology, Ludwig-Maximilians-Universität, Germany. Electronic address: eggert@lrz.uni-muenchen.de.
authors.forename: Thomas
authors.initials: T
authors.lastname: Eggert
authors.affiliation: Department of Neurology, Ludwig-Maximilians-Universität, Germany.
authors.forename: Johannes
authors.initials: J
authors.lastname: Drever
authors.affiliation: Department of Neurology, Ludwig-Maximilians-Universität, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Straube
mesh_terms: D000328:Adult; D006801:Humans; D007100:Imitative Behavior; D008568:Memory; D009043:Motor Activity; D046709:Pattern Recognition, Physiological; D013028:Space Perception; D055815:Young Adult
keywords: Explicit memory; Imitation learning; Pointing movements; Sequence learning; Spatial imagination