title: Agreement of histopathological findings of preoperative uterine curettage and hysterectomy specimens: impact of time factor and hormonal therapy.
abstract: OBJECTIVE
  To study the agreement of preoperative curettage and definitive histology after hysterectomy as well as the correlation of time factor and hormonal therapy to this agreement.
  
  
  METHODS
  This retrospective study was done in the Departments of Obstetrics and Gynecology and Pathology, Faculty of Medicine, Mansoura University, Egypt. Pathology reports of patients exposed to dilatation and curettage followed by hysterectomy during the period from May, 2004 to April, 2011 were reviewed.
  
  
  RESULTS
  We reviewed 83 cases who fulfilled the inclusion criteria. There were non-significant differences between findings of D&C and hysterectomy specimens (P = 0.42). The concordance rate between D&C and hysterectomy was 79.5%. One case of endometrial carcinoma (1.2%), one case of simple endometrial hyperplasia, one case of atrophic endometrium, and two cases of endometrial polyp were diagnosed only after hysterectomy (4.8%). Furthermore, histologic examination of hysterectomy specimens confirmed only 8 of 13 cases (61.5%) of endometrial hyperplasia with atypia. No significant correlation of time factor and hormonal therapy to the agreement between findings of D&C and hysterectomy specimens (P = 0.58 & 0.19 respectively).
  
  
  CONCLUSIONS
  There was no significant difference between preoperative endometrial histology and hysterectomy specimens (P = 0.41).This agreement had not been significantly affected by time interval and hormonal therapy. Future researches with larger number of cases are needed to confirm or disagree with our findings.
authors.affiliation: Department of Obstetrics and Gynecology, Mansoura University, Egypt. redaelshouky@hotmail.com
authors.forename: Reda A
authors.initials: RA
authors.lastname: Hemida
authors.affiliation: Department of Obstetrics and Gynecology, Mansoura University, Egypt.
authors.forename: Abd Elhady
authors.initials: AE
authors.lastname: Zayed
authors.affiliation: Department of Pathology, Mansoura University, Egypt.
authors.forename: Asem
authors.initials: A
authors.lastname: Shalaby
authors.affiliation: Department of Obstetrics and Gynecology, Mansoura University, Egypt.
authors.forename: Hosam
authors.initials: H
authors.lastname: Goda
authors.affiliation: Department of Obstetrics and Gynecology, Mansoura University, Egypt.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Fawzy
authors.affiliation: Department of Obstetrics and Gynecology, Mansoura University, Egypt.
authors.forename: Abdel Aziz
authors.initials: AA
authors.lastname: El Refaeey
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004107:Dilatation and Curettage; D004714:Endometrial Hyperplasia / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D014599:Uterus / Q000473:pathology*