title: Renal denervation for hypertension.
abstract: Hypertension is the leading cause of mortality worldwide. Effective therapies are needed for resistant hypertension, a common condition characterized by inadequate blood pressure control despite 3 or more medications, which is associated with increased cardiovascular mortality. Percutaneous catheter-based renal denervation is a promising new treatment offering the potential to improve blood pressure control, reduce cardiovascular risk, and target end-organ damage in patients with resistant hypertension. Initial studies have demonstrated procedural safety and effectiveness in blood pressure reduction up to 2 years after procedure. Large randomized control trials are necessary and currently underway to define further the role of renal denervation and long-term consequences in the treatment of resistant hypertension.
authors.forename: Mackram F
authors.initials: MF
authors.lastname: Eleid
authors.forename: Gary L
authors.initials: GL
authors.lastname: Schwartz
authors.forename: Rajiv
authors.initials: R
authors.lastname: Gulati
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D019317:Evidence-Based Medicine / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000601:surgery*; D006977:Hypertension, Renal / Q000601:surgery; D007668:Kidney / Q000294:innervation* / Q000601:surgery; D011182:Postoperative Care / Q000379:methods; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000294:innervation / Q000601:surgery; D013562:Sympathectomy / Q000379:methods*