title: Denervation of nerve terminals in renal arteries: one-year follow-up of interventional treatment of arterial hypertension.
abstract: BACKGROUND
  Arterial hypertension is the most common cardiovascular system disease, affecting nearly one billion people worldwide. Despite the widespread use of antihypertensive medications, in some groups of patients an optimal blood pressure (BP) cannot be achieved.
  
  
  OBJECTIVE
  To assess BP reduction in patients with resistant hypertension after a catheter-based renal sympathetic denervation procedure and to report vascular and kidney safety in one-year follow-up.
  
  
  METHODS
  Twenty eight patients with diagnosed resistant hypertension (median age 52.02 years, range 42-72) underwent percutaneous catheter-based renal denervation of nerve terminals in renal arteries. Arterial angiography and procedure of ablation was performed by Symplicity catheters and generator provided by Ardian (currently Medtronic Inc., USA).
  
  
  RESULTS
  Mean BP value before ablation was [mm Hg]: systolic 176.6, diastolic 100.28 and pulse pressure 73.4. After the procedure, reductions in the value of BP were reported [mm Hg]: systolic 154.8/152.54; diastolic 90.2/89.8, pulse pressure 64.66/62.73, respectively in nine-month and one-year follow-up. All results were statistically significant. No complications during one year observation were observed.
  
  
  CONCLUSIONS
  Percutaneous renal artery ablation procedure effectively reduces systolic BP, diastolic BP, and pulse pressure. No vascular or renal complications in any of the patients were observed. The results of a Polish research group showed no significant differences compared to the results obtained in the international studies Symplicity I and Symplicity II.
authors.affiliation: Department of Cardiovascular Surgery and Transplantology, Jagiellonian University, John Paul II Hospital, Krakow, Poland. cool_chris@interia.pl.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Bartuś
authors.forename: Jerzy
authors.initials: J
authors.lastname: Sadowski
authors.forename: Bogusław
authors.initials: B
authors.lastname: Kapelak
authors.forename: Radosław
authors.initials: R
authors.lastname: Litwinowicz
authors.forename: Wojciech
authors.initials: W
authors.lastname: Zajdel
authors.forename: Jacek
authors.initials: J
authors.lastname: Godlewski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Bartuś
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zmudka
authors.forename: Anna
authors.initials: A
authors.lastname: Chrapusta
authors.forename: Janusz
authors.initials: J
authors.lastname: Konstanty-Kalandyk
authors.forename: Piotr
authors.initials: P
authors.lastname: Węgrzyn
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sobotka
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000294:innervation; D013562:Sympathectomy / Q000379:methods*; D016896:Treatment Outcome