title: Estimated glomerular filtration rate is associated with both arterial stiffness and N-terminal pro-brain natriuretic peptide in newly diagnosed hypertensive patients.
abstract: Even a slight decrease in the glomerular filtration rate (GFR) is an independent risk factor for cardiovascular disease. Arterial stiffness, left ventricular hypertrophy and N-terminal pro-brain natriuretic peptide (NT-proBNP) are independent risk factors for cardiovascular disease, which are particularly common in end-stage renal disease. We aimed to evaluate the association between GFR with arterial stiffness, left ventricle mass (LVM) and NT-proBNP in hypertensive subjects with normal to mildly impaired renal function. The study population consisted of 285 newly diagnosed hypertensive patients (mean age; 49.9 ± 11.8 years). GFR was estimated (eGFR) by the Modification of Diet in Renal Disease formula. Pulse wave velocity (PWV) and augmentation index (AIx), which reflects arterial stiffness, were calculated using the single-point method via the Mobil-O-Graph® ARCsolver algorithm. LVM was obtained by echocardiography. Plasma NT-proBNP was measured by electrochemiluminescence. The patients were divided into two groups according to the median eGFR value (eGFRlow group <101 ml/min/1.73 m(2) and eGFRhigh group ≥ 101 ml/min/1.73 m(2)). LVM and NT-proBNP values were higher in eGFRlow group compared with eGFRhigh group (p<0.05). Pulse wave velocity and augmentation index values were higher in eGFRlow group compared with eGFRhigh group (p<0.05, for all). Multiple linear regression analysis showed that eGFR was independently associated with PWV (β=-0.422, p<0.001) and NT-proBNP (β=-0.404, p<0.001). Present study showed that eGFR was independently associated with PWV and NT-proBNP values. Importantly, these findings may explain, in part, the increase in cardiovascular risk in with slightly impaired renal function.
authors.affiliation: Department of Cardiology, Adana Numune Training and Research Hospital , Adana , Turkey and.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gür
authors.forename: Hakan
authors.initials: H
authors.lastname: Uçar
authors.forename: Osman
authors.initials: O
authors.lastname: Kuloğlu
authors.forename: Ali
authors.initials: A
authors.lastname: Kıvrak
authors.forename: Taner
authors.initials: T
authors.lastname: Şeker
authors.forename: Caner
authors.initials: C
authors.lastname: Türkoğlu
authors.forename: Betül
authors.initials: B
authors.lastname: Özaltun
authors.forename: Onur
authors.initials: O
authors.lastname: Kaypaklı
authors.forename: Durmuş Yıldıray
authors.initials: DY
authors.lastname: Şahin
authors.forename: Zafer
authors.initials: Z
authors.lastname: Elbasan
authors.forename: Halil İbrahim
authors.initials: Hİ
authors.lastname: Tanboğa
authors.forename: Murat
authors.initials: M
authors.lastname: Çaylı
mesh_terms: D000328:Adult; D000465:Algorithms; D002318:Cardiovascular Diseases; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D063177:Pulse Wave Analysis; D012044:Regression Analysis; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology*
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: Arterial stiffness; BNP; GFR; hypertension; left ventricle mass