title: Large simple trials: really, it can't be that simple!
authors.affiliation: Duke Translational Medicine Institute, Durham, NC, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Califf
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000379:methods*