title: Prognosis of adenosquamous carcinoma compared with adenocarcinoma in uterine cervical cancer: a systematic review and meta-analysis of observational studies.
abstract: OBJECTIVE
  The aim of this study was to compare the survival outcomes of adenosquamous carcinoma (ASC) and adenocarcinoma (AC) of the cervix.
  
  
  METHODS
  We searched PubMed and Embase for observational studies that compared the outcomes of 2 histologic subtypes. Hazards ratios (HRs) with 95% confidence intervals (CIs) were calculated with a fixed effects model.
  
  
  RESULTS
  A total of 17 studies were included in the analyses. Patients with ASC were associated significantly with poorer overall survival (death HR, 1.27; 95% CI, 1.12-1.43; I(2) = 0%) and recurrence-free survival (recurrence HR, 1.43; 95% CI, 1.05-1.95; I(2) = 19.4%) than those with AC. For clinical stages I and II in particular, ASC predicted significantly poorer outcomes compared with AC (death HR, 1.41; 95% CI, 1.17-1.70; I(2) = 0%).
  
  
  CONCLUSIONS
  This meta-analysis suggests that ASC may have poorer outcomes compared with AC of the cervix.
authors.affiliation: *Department of Obstetrics and Gynecology, College of Medicine, Seoul National University; †Department of Obstetrics and Gynecology, Inje University Sanggye Paik Hospital; and ‡Departments of Medicine, and §Pathology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jung-Yun
authors.initials: JY
authors.lastname: Lee
authors.forename: Chulmin
authors.initials: C
authors.lastname: Lee
authors.forename: Seokyung
authors.initials: S
authors.lastname: Hahn
authors.forename: Min A
authors.initials: MA
authors.lastname: Kim
authors.forename: Hee Seung
authors.initials: HS
authors.lastname: Kim
authors.forename: Hyun Hoon
authors.initials: HH
authors.lastname: Chung
authors.forename: Jae-Weon
authors.initials: JW
authors.lastname: Kim
authors.forename: Noh Hyun
authors.initials: NH
authors.lastname: Park
authors.forename: Yong-Sang
authors.initials: YS
authors.lastname: Song
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000401:mortality*; D018196:Carcinoma, Adenosquamous / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D006801:Humans; D064887:Observational Studies as Topic; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000401:mortality*