title: Posterior capsule opacification and neodymium:YAG rates with 2 single-piece hydrophobic acrylic intraocular lenses: three-year results.
abstract: OBJECTIVE
  To compare the incidence and intensity of posterior capsule opacification (PCO) between 2 similar 1-piece foldable hydrophobic acrylic intraocular lenses (IOLs) over 3 years.
  
  
  METHODS
  Department of Ophthalmology, Medical University Vienna, Vienna, Austria.
  
  
  METHODS
  Randomized prospective patient- and examiner-masked clinical trial with intraindividual comparison.
  
  
  METHODS
  Patients with bilateral age-related cataract had cataract surgery and implantation of a Tecnis ZCB00 continuous-optic-edge IOL in 1 eye and an Acrysof SA60AT interrupted-optic-edge IOL in the other eye. Postoperative examinations were performed at 6 months and 3 years. Digital retroillumination images were taken of each eye. The amount of PCO (score 0 to 10) was assessed subjectively at the slitlamp and objectively using automated image-analysis software.
  
  
  RESULTS
  The study comprised 54 patients (108 eyes). The mean objective PCO score was 1.3 ± 1.7 (SD) for the continuous-optic-edge IOLs and 0.9 ± 1.3 for the interrupted-optic-edge IOLs (P=.10). Three years postoperatively, a neodymium:YAG (Nd:YAG) capsulotomy was performed in 26.1% of eyes with the continuous-optic-edge IOL and 21.7% with the interrupted-optic-edge IOL (P=.56). There was no significant difference in corrected distance visual acuity, capsulorhexis–IOL overlap, capsule folds, or anterior capsule opacification 3 years after surgery.
  
  
  CONCLUSIONS
  Both IOLs had comparable PCO and Nd:YAG rates 3 years postoperatively. The optimized barrier function of the continuous-optic-edge IOL and the material properties of the interrupted-optic-edge IOL seemingly outbalanced the effect on lens epithelial cell migration and proliferation beneath the optic.
authors.forename: Christina
authors.initials: C
authors.lastname: Leydolt
authors.forename: Katharina
authors.initials: K
authors.lastname: Kriechbaum
authors.forename: Sabine
authors.initials: S
authors.lastname: Schriefl
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Pachala
authors.forename: Rupert
authors.initials: R
authors.lastname: Menapace
mesh_terms: D000180:Acrylic Resins; D000368:Aged; D058442:Capsule Opacification / Q000453:epidemiology* / Q000209:etiology / Q000601:surgery; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D015994:Incidence; D053844:Lasers, Solid-State / Q000627:therapeutic use*; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D018918:Phacoemulsification; D057852:Posterior Capsule of the Lens / Q000473:pathology* / Q000601:surgery; D064727:Posterior Capsulotomy / Q000706:statistics & numerical data*; D011183:Postoperative Complications; D011446:Prospective Studies; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000180:Acrylic Resins