title: Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology.
abstract: Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T lymphocytes, hence allowing for disease progression. Ketogenic diets can deplete tumor-bearing animals from MDSCs and regulatory T cells, thereby improving their immunological profile.
authors.affiliation: Division of Interdisciplinary Medicine and Biotechnology; Beth-Israel Deaconess Medical Hospital; Harvard Medical School; Boston, MA USA ; Department of Medicine; Beth-Israel Deaconess Medical Hospital; Harvard Medical School; Boston, MA USA.
authors.forename: Zaheed
authors.initials: Z
authors.lastname: Husain
authors.affiliation: Division of Interdisciplinary Medicine and Biotechnology; Beth-Israel Deaconess Medical Hospital; Harvard Medical School; Boston, MA USA ; Department of Medicine; Beth-Israel Deaconess Medical Hospital; Harvard Medical School; Boston, MA USA.
authors.forename: Pankaj
authors.initials: P
authors.lastname: Seth
authors.affiliation: Division of Interdisciplinary Medicine and Biotechnology; Beth-Israel Deaconess Medical Hospital; Harvard Medical School; Boston, MA USA ; Department of Medicine; Beth-Israel Deaconess Medical Hospital; Harvard Medical School; Boston, MA USA.
authors.forename: Vikas P
authors.initials: VP
authors.lastname: Sukhatme
keywords: MDSCs; NK cells; glycolysis; ketogenic diet; lactate