title: LeuO, a dormant sentinel for SPI-1?
abstract: A new mechanism for the turning-off of gene expression in Salmonella Pathogenicity Island 1 (SPI-1) is proposed by Espinosa and Casadesús, which involves the action of the LeuO quiescent regulator, by two different pathways. A major one through the activation of the hilE gene, where the HilE protein would in turn inactivate HilD, a major positive transcriptional regulator of SPI-1; and a minor HilE-HilD-independent pathway. This could constitute a back-up or an aid for the turn-off of SPI-1 genes mediated by the nucleoid protein H-NS.
authors.affiliation: Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, 62210, Mexico.
authors.forename: Víctor H
authors.initials: VH
authors.lastname: Bustamante
authors.forename: Edmundo
authors.initials: E
authors.lastname: Calva
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis*; D015964:Gene Expression Regulation, Bacterial; D044404:Genomic Islands; D012097:Repressor Proteins / Q000096:biosynthesis*; D012486:Salmonella typhimurium / Q000235:genetics*; D014157:Transcription Factors / Q000378:metabolism*; D037521:Virulence Factors / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D037521:Virulence Factors