title: Gold nanorod-embedded electrospun fibrous membrane as a photothermal therapy platform.
abstract: A strategy of using a gold nanorod (GNR)-loaded electrospun membrane as a photothermal therapy platform of cancer is reported. The strategy takes both the advantages of the excellent photothermal properties of GNRs to selectively kill the cancerous cells, and the widely used biodegradable electrospun membrane to serve as GNR-carrier and surgical recovery material. PEG modified GNRs were embedded into the electrospun fibrous membrane which was composed of PLGA and PLA-b-PEG with an 85:15 ratio. After incubation with the cells in the cell culture medium, the PEG-GNRs were released from the membrane and taken up by cancer cells, allowing the generation of heat upon NIR irradiation to induce cancer cell death. We have demonstrated that the use of PEG-GNR-embedded membrane selectively killed the cancerous cells and effectively inhibited cancer cell proliferation though in vitro experiments. The PEG-GNRs-loaded membrane is a promising material for postsurgical recovery of cancer.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Key Laboratory of Molecular Nanostructures and Nanotechnology, Chinese Academy of Sciences , Beijing 100190, P. R. China.
authors.forename: Ming
authors.initials: M
authors.lastname: Cheng
authors.forename: Heran
authors.initials: H
authors.lastname: Wang
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Fang
authors.forename: Shanshan
authors.initials: S
authors.lastname: Xu
mesh_terms: D016923:Cell Death; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007773:Lactates / Q000737:chemistry; D008567:Membranes, Artificial; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010789:Phototherapy / Q000379:methods*; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D007773:Lactates; D008567:Membranes, Artificial; C088513:poly(lactic acid-ethylene glycol); D011092:Polyethylene Glycols; D006046:Gold