title: Development of macular edema and impact on visual acuity in uveitis associated with juvenile idiopathic arthritis.
abstract: OBJECTIVE
  To investigate the development of macular edema (ME) in relation to the duration of uveitis and visual outcome in uveitis associated with juvenile idiopathic arthritis (JIA).
  
  
  METHODS
  Sixty-one patients with JIA-uveitis (116 eyes) were investigated by Cirrus OCT for macular thickness. The relation between macular thickness and time interval since onset of uveitis and best corrected visual acuity (BCVA) was analyzed by linear mixed effect models.
  
  
  RESULTS
  Duration of follow-up showed significant positive linear relation with central macular thickness. The central macular thickness showed a significant linear relation with BCVA, but not with disease activity. Thirteen patients developed ME (central field thickness >304.4 µm) after a mean time interval of 11.6 years. Thirteen patients had macular thinning after a significant longer interval of uveitis compared to patients with normal or thickened macula.
  
  
  CONCLUSIONS
  Duration of JIA-uveitis is positively correlated with the development of ME, compromising the visual acuity.
authors.affiliation: Department of Ophthalmology, University Medical Center Utrecht , Utrecht , The Netherlands and.
authors.forename: Joke
authors.initials: J
authors.lastname: de Boer
authors.forename: Arjen
authors.initials: A
authors.lastname: Steijaert
authors.forename: Rutger
authors.initials: R
authors.lastname: van den Bor
authors.forename: Rebecca
authors.initials: R
authors.lastname: Stellato
authors.forename: Jeannette
authors.initials: J
authors.lastname: Ossewaarde-van Norel
mesh_terms: D000293:Adolescent; D000328:Adult; D001171:Arthritis, Juvenile / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D005584:Fovea Centralis / Q000473:pathology*; D006801:Humans; D007223:Infant; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014605:Uveitis / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D014792:Visual Acuity; D055815:Young Adult
keywords: Juvenile idiopathic arthritis; OCT; macular edema; macular thinning; uveitis