title: Association of plasma GDF-9 or GDF-15 levels with bone parameters in polycystic ovary syndrome.
abstract: We aimed to determine plasma levels of growth and differentiation factor (GDF)-9 and GDF-15, and their possible association with bone turnover parameters and bone mineral density (BMD), in patients with polycystic ovary syndrome (PCOS). Forty-two obese PCOS women aged 25-35 years, 23 women with idiopathic hirsutism (IH) and 20 healthy controls matched for age and body mass index were enrolled. Anthropometric, metabolic and hormonal patterns, plasma GDF-9 and GDF-15 concentrations, bone turnover markers and BMD were measured. No significant differences were observed in bone turnover markers, BMD measurements, plasma GDF-9 and GDF-15 levels in subjects with PCOS compared with the other two groups. In the combined population of all three groups, GDF-15 concentrations were negatively correlated with osteocalcin (r = -0.317, p < 0.01). Analysis of PCOS patients showed a significant correlation of GDF-15 concentrations with age and homeostasis model assessment index (r = 0.319, p < 0.05, and r = 0.312, p < 0.05, respectively). In addition, GDF-15 concentrations were negatively correlated with osteocalcin (r = -0.395, p < 0.01) and positively correlated with urine deoxypyridinoline (r = 0.353, p < 0.05). GDF-9 did not correlate with bone markers and BMD measurements. In conclusion, plasma GDF-9 and GDF-15 levels as well as bone turnover markers and BMD measurements in subjects with PCOS (25-35 years of age) were comparable with those either in subjects with IH or in healthy controls with similar anthropometric and metabolic profiles. GDF-15 might be a marker of a crossregulation between bone and energy metabolism.
authors.affiliation: Department of Endocrinology and Metabolism, Ankara Education and Research Hospital, Şükriye Mh, 06340, Sıhhıye, Ankara, Turkey, zehraberberoglu@gmail.com.
authors.forename: Zehra
authors.initials: Z
authors.lastname: Berberoglu
authors.forename: Aynur
authors.initials: A
authors.lastname: Aktas
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Fidan
authors.forename: Ayse Canan
authors.initials: AC
authors.lastname: Yazici
authors.forename: Yalcin
authors.initials: Y
authors.lastname: Aral
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000652:urine; D000886:Anthropometry; D015992:Body Mass Index; D015519:Bone Density / Q000187:drug effects; D016022:Case-Control Studies; D004734:Energy Metabolism; D005260:Female; D055436:Growth Differentiation Factor 15 / Q000097:blood*; D055429:Growth Differentiation Factor 9 / Q000097:blood*; D006628:Hirsutism / Q000097:blood; D006706:Homeostasis; D006728:Hormones / Q000378:metabolism; D006801:Humans; D009765:Obesity / Q000503:physiopathology; D015675:Osteocalcin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood*
chemical_list: D000596:Amino Acids; C526140:GDF15 protein, human; C525897:GDF9 protein, human; D055436:Growth Differentiation Factor 15; D055429:Growth Differentiation Factor 9; D006728:Hormones; D015675:Osteocalcin; C036020:deoxypyridinoline