title: Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes.
abstract: Pluripotent stem cells (PSCs) represent an appealing source from which to develop cell replacement therapies. Different initiatives have been launched to promote their development toward clinical applications. This article will review the main questions that should be considered before translating PSC-derived cardiomyocytes into clinical investigations, including the development of good manufacturing practice-level PSC lines, the development of efficient protocols to generate pure populations of cardiac myocytes, and the development of techniques to improve the retention and survival rate of transplanted cells.
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Hulot
authors.forename: Francesca
authors.initials: F
authors.lastname: Stillitano
authors.forename: Joe Elie
authors.initials: JE
authors.lastname: Salem
authors.forename: Jason C
authors.initials: JC
authors.lastname: Kovacic
authors.forename: Valentin
authors.initials: V
authors.lastname: Fuster
authors.forename: Roger J
authors.initials: RJ
authors.lastname: Hajjar
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002986:Clinical Trials as Topic; D006801:Humans; D032383:Myocytes, Cardiac / Q000166:cytology*; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000637:transplantation*; D033581:Stem Cell Transplantation / Q000379:methods*