title: The Potential Role of Chemokines in Alzheimer's Disease Pathogenesis.
abstract: Alzheimer's disease (AD) is a neurodegenerative disorder and leading cause of dementia, which begins with impaired memory. The neuropathological hallmarks of AD include destructive alterations of neurons by neurofibrillary tangles, neuritic amyloid plaques, and neuroinflammatory process in the brain. Chemokines have a major role in inflammatory cell attraction and glial cell activation and/or modulation in the central nervous system. Moreover, the clinical and immunopathological evidence could show dual key role of chemokines in their pro- and anti-inflammatory properties in AD. However, their effects in neurodegeneration and/or neuroprotection remain an area of investigation. This review article provides an overview of characteristic, cellular source and activity of chemokines, and their roles in neuronal glial cell interaction in AD.
authors.affiliation: Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.
authors.forename: Gholamreza
authors.initials: G
authors.lastname: Azizi
authors.affiliation: Department of Molecular and Cellular Biology, College of Science, University of Tehran, Tehran, Iran.
authors.forename: Nikoo
authors.initials: N
authors.lastname: Khannazer
authors.affiliation: Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran mirshafiey@tums.ac.ir.
authors.forename: Abbas
authors.initials: A
authors.lastname: Mirshafiey
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology / Q000276:immunology*; D018925:Chemokines / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology*
chemical_list: D018925:Chemokines
keywords: Alzheimer’s disease; CCL2; CCL3; CCL5; CX3CL1; CXCL12; CXCL8; MIF; chemokine; inflammation; neurodegeneration