title: The membrane insertase YidC.
abstract: The membrane insertases YidC-Oxa1-Alb3 provide a simple cellular system that catalyzes the transmembrane topology of newly synthesized membrane proteins. The insertases are composed of a single protein with 5 to 6 transmembrane (TM) helices that contact hydrophobic segments of the substrate proteins. Since YidC also cooperates with the Sec translocase it is widely involved in the assembly of many different membrane proteins including proteins that obtain complex membrane topologies. Homologues found in mitochondria (Oxa1) and thylakoids (Alb3) point to a common evolutionary origin and also demonstrate the general importance of this cellular process. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey.
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA. Electronic address: dalbey@chemistry.ohio-state.edu.
authors.forename: Ross E
authors.initials: RE
authors.lastname: Dalbey
authors.affiliation: Institute of Microbiology and Molecular Biology, University of Hohenheim, Garbenstr 30, 70599 Stuttgart, Germany. Electronic address: Andreas.Kuhn@uni-hohenheim.de.
authors.forename: Andreas
authors.initials: A
authors.lastname: Kuhn
authors.affiliation: Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210, USA.
authors.forename: Lu
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Institute of Microbiology and Molecular Biology, University of Hohenheim, Garbenstr 30, 70599 Stuttgart, Germany.
authors.forename: Doro
authors.initials: D
authors.lastname: Kiefer
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D003576:Electron Transport Complex IV / Q000737:chemistry / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D009687:Nuclear Proteins / Q000737:chemistry / Q000378:metabolism; D017510:Protein Folding; D021381:Protein Transport / Q000235:genetics*; D000069816:SEC Translocation Channels; D000081416:SecA Proteins; D060431:Thylakoid Membrane Proteins / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D009687:Nuclear Proteins; C090858:OXA1 protein; D000069816:SEC Translocation Channels; D060431:Thylakoid Membrane Proteins; C412443:YIDC protein, E coli; D003576:Electron Transport Complex IV; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins
keywords: Membrane insertase; Membrane targeting; Mitochondrion; Sec translocase; Thylakoid; Topology