title: A centralized recipient database enhances the serologic safety of RBC transfusions for patients with sickle cell disease.
abstract: OBJECTIVE
  To evaluate the utility of a centralized transfusion service model in preventing the transfusion of incompatible units in patients with sickle cell disease (SCD).
  
  
  METHODS
  The serologic records of transfused patients with SCD were reviewed. The index hospital was where an alloantibody was initially detected.
  
  
  RESULTS
  In total, 150 patients with SCD were evaluated; 66 (44.0%) of 150 were alloimmunized. In 42 (63.6%) of these patients, 1 or more antibodies evanesced. The median number of hospitals visited by patients with SCD for RBC transfusion with 1 or more evanesced antibodies was three (range, one to eight); the median number of nonindex hospitals was two (range, one to seven). Of the patients with evanesced antibodies, 28.6% received transfusions at various nonindex hospitals 20 or more times after the antibody evanesced.
  
  
  CONCLUSIONS
  A centralized database can help identify patients with SCD who have evanesced alloantibodies and prevent issuing incompatible RBC units.
authors.affiliation: Puget Sound Blood Center, 921 Terry Ave, Seattle, WA 98104; meghand@psbc.org.
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Harm
authors.forename: Mark H
authors.initials: MH
authors.lastname: Yazer
authors.forename: Grace F
authors.initials: GF
authors.lastname: Monis
authors.forename: Darrell J
authors.initials: DJ
authors.lastname: Triulzi
authors.forename: James P
authors.initials: JP
authors.lastname: Aubuchon
authors.forename: Meghan
authors.initials: M
authors.lastname: Delaney
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood / Q000276:immunology / Q000628:therapy*; D001787:Blood Group Incompatibility / Q000517:prevention & control*; D001788:Blood Grouping and Crossmatching / Q000379:methods*; D016208:Databases, Factual; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D006801:Humans; D007518:Isoantibodies / Q000097:blood*
chemical_list: D007518:Isoantibodies
keywords: Alloantibody; Centralized transfusion service; Database; Delayed hemolytic reaction; Evanescence; Red blood cell; Sickle cell