title: Correlation and multiple regression analyses of pituitary growth hormone and hepatic activities in hepatitis C infection and interferon response.
abstract: The prevalence of hepatitis C virus (HCV) infection varies across the world, with the highest percent of infections reported in Middle East, increasingly in Egypt. The current study aimed at examining the bio-statistical correlation and multiple regression analyses of pituitary growth hormone (GH) and liver activities among HCV genotype-4 patients treated with PEG-IFN-α plus RBV therapy. Herein, the current study was conducted on 100 HCV genotype-4 infected patients and 50 healthy controls. Patients received PEG-IFN-α/RBV for 24 weeks. Host RNA was isolated from patients' sera for HCV genotyping and viral load determination. Moreover, the enzymatic activities of the liver, AFP, GH, PT, and CBC were performed in all volunteers. The present study resulted that the activities of the hepatic enzymes among HCV genotype-4 patients correlated together significantly. While, human GH showed a significant positive regression with pre-treatment ALT concentration in responders. Furthermore, multiple regression analysis for GH showed a significant positive correlation with pre-treatment ALT in HCV genotype-4 infected patients. We concluded that there were a putative significant relation between GH and pre-treatment ALT activity in HCV infection and response to IFN-based therapy.
authors.affiliation: Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt.
authors.forename: Emad F
authors.initials: EF
authors.lastname: Eskander
authors.affiliation: Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt ; Center for Aging and Associated Diseases, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Sheikh Zayed District, 6th of October City, Giza, Egypt.
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Abd-Rabou
authors.affiliation: Hormones Department, Medical Research Division, National Research Centre, Cairo, Egypt.
authors.forename: Shaymaa M M
authors.initials: SM
authors.lastname: Yahya
authors.affiliation: Internal Medicine Department, Medical Research Division, National Research Centre, Cairo, Egypt.
authors.forename: Ashraf
authors.initials: A
authors.lastname: El Sherbini
authors.affiliation: Chemistry Department, Biochemistry Specialty, Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: Mervat S
authors.initials: MS
authors.lastname: Mohamed
authors.affiliation: Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Giza, Egypt.
authors.forename: Olfat G
authors.initials: OG
authors.lastname: Shaker
keywords: Hepatitis C; Interferon; Liver enzymes; Pituitary growth hormone