title: Biological evaluation of new antitumor taxoids: alteration of substitution at the C-7 and C-10 of docetaxel.
abstract: A series of new docetaxol analogues have been designed and synthesized. And their cytotoxicities against cancer cells have been evaluated by MTT method. Most of these compounds showed selective inhibitions on human cancer cell lines. Among them, compound 8 exhibited higher inhibitory activity than Paclitaxel (Taxol) against several cancer cell lines. This work indicated that appropriate modification at C-7 and C-10 of docetaxel might be a promising approach for this unique class of anticancer compounds.
authors.affiliation: College of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 210032, China.
authors.forename: Caihong
authors.initials: C
authors.lastname: Li
authors.affiliation: Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
authors.forename: Yatao
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: College of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 210032, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 210032, China.
authors.forename: Nianjin
authors.initials: N
authors.lastname: Liu
authors.affiliation: College of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 210032, China. Electronic address: yao99cn@sit.edu.cn.
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Yao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001681:Biological Assay; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D000077143:Docetaxel; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D017239:Paclitaxel / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D043823:Taxoids / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel
keywords: Analogues; Antitumor; Biological assays; Cabazitaxel; Paclitaxel