title: Biocompatible polysaccharide-based cryogels.
abstract: This study focuses on the development of novel biocompatible macroporous cryogels by electron-beam assisted free-radical crosslinking reaction of polymerizable dextran and hyaluronan derivatives. As a main advantage this straightforward approach provides highly pure materials of high porosity without using additional crosslinkers or initiators. The cryogels were characterized with regard to their morphology and their basic properties including thermal and mechanical characteristics, and swellability. It was found that the applied irradiation dose and the chemical composition strongly influence the material properties of the resulting cryogels. Preliminary cytotoxicity tests illustrate the excellent in vitro-cytocompatibility of the fabricated cryogels making them especially attractive as matrices in tissue regeneration procedures.
authors.affiliation: Leibniz Institute of Surface Modification, Permoserstr. 15, 04318 Leipzig, Germany. Electronic address: senta.reichelt@iom-leipzig.de.
authors.forename: Senta
authors.initials: S
authors.lastname: Reichelt
authors.affiliation: Innovent e.V., Pruessingstr. 27B, 07745 Jena, Germany.
authors.forename: Jana
authors.initials: J
authors.lastname: Becher
authors.affiliation: Innovent e.V., Pruessingstr. 27B, 07745 Jena, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Weisser
authors.affiliation: Leibniz Institute of Surface Modification, Permoserstr. 15, 04318 Leipzig, Germany.
authors.forename: Andrea
authors.initials: A
authors.lastname: Prager
authors.affiliation: Leibniz Institute of Surface Modification, Permoserstr. 15, 04318 Leipzig, Germany.
authors.forename: Ulrich
authors.initials: U
authors.lastname: Decker
authors.affiliation: Innovent e.V., Pruessingstr. 27B, 07745 Jena, Germany.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Möller
authors.affiliation: Innovent e.V., Pruessingstr. 27B, 07745 Jena, Germany.
authors.forename: Albrecht
authors.initials: A
authors.lastname: Berg
authors.affiliation: Innovent e.V., Pruessingstr. 27B, 07745 Jena, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schnabelrauch
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D059985:Cryogels / Q000138:chemical synthesis* / Q000633:toxicity*; D003911:Dextrans / Q000737:chemistry* / Q000528:radiation effects / Q000633:toxicity*; D055119:Elastic Modulus; D004583:Electrons; D006244:Hardness; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000528:radiation effects / Q000633:toxicity*; D008422:Materials Testing; D051379:Mice; D013814:Thermal Conductivity
chemical_list: D001672:Biocompatible Materials; D059985:Cryogels; D003911:Dextrans; D006820:Hyaluronic Acid
keywords: Biocompatibility; Cell cultivation; Cryogel; Electron-beam; Polysaccharides