title: [Treatment of septic shock by removing blood endotoxin].
abstract: Sepsis and its complications remain the principal cause of death in intensive care units, and is associated with high costs. Protocolized care of septic shock has however lately been associated with decreased death rates, but to date there is still no specific treatment for sepsis. Pharmacologic therapies aiming at blocking the action of bacterial endotoxin or its receptor have been largely disappointing. Epuration of circulating endotoxin using hemoadsorption on polymyxin columns is a new treatment in septic shock showing encouraging preliminary results. Studies reporting such results, and hypotheses for a potential beneficial effect of this type of therapy are discussed in this article.
authors.affiliation: Services des soins intensifs, HUG, 1211 Genève 14 et Faculté de médecine, Universitê de Genève, 1211 Genève 4.
authors.forename: Mia
authors.initials: M
authors.lastname: Gisselbaek
authors.affiliation: Services des soins intensifs, HUG, 1211 Genève 14 et Faculté de médecine, Universitê de Genève, 1211 Genève 4.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Pugin
authors.affiliation: Service d'anesthésiologie, HUG, 1211 Genève 14 et Faculté de médecine, Universitê de Genève, 1211 Genève 4.
authors.forename: Gordana
authors.initials: G
authors.lastname: Pavlovic
mesh_terms: D004731:Endotoxins / Q000097:blood*; D006440:Hemofiltration; D006801:Humans; D012772:Shock, Septic / Q000097:blood* / Q000628:therapy*
chemical_list: D004731:Endotoxins