title: Light-responsive micelles of spiropyran initiated hyperbranched polyglycerol for smart drug delivery.
abstract: Light-responsive polymeric micelles have emerged as site-specific and time-controlled systems for advanced drug delivery. Spiropyran (SP), a well-known photochromic molecule, was used to initiate the ring-opening multibranching polymerization of glycidol to afford a series of hyperbranched polyglycerols (SP-hb-PG). The micelle assembly and disassembly were induced by an external light source owing to the reversible photoisomerization of hydrophobic SP to hydrophilic merocyanine (MC). Transmission electron microscopy, atomic force microscopy, UV/vis spectroscopy, and dynamic light scattering demonstrated the successful assembly and disassembly of SP-hb-PG micelles. In addition, the critical micelle concentration (CMC) was determined through the fluorescence analysis of pyrene to confirm the amphiphilicity of respective SP-hb-PGn (n = 15, 29, and 36) micelles, with CMC values ranging from 13 to 20 mg/L, which is correlated to the length of the polar polyglycerol backbone. Moreover, the superior biocompatibility of the prepared SP-hb-PG was evaluated using WI-38 cells and HeLa cells, suggesting the prospective applicability of the micelles in smart drug delivery systems.
authors.affiliation: Department of Chemistry and Interdisciplinary School of Green Energy, Ulsan National Institute of Science and Technology (UNIST) , Ulsan 689-798, Korea.
authors.forename: Suhyun
authors.initials: S
authors.lastname: Son
authors.forename: Eeseul
authors.initials: E
authors.lastname: Shin
authors.forename: Byeong-Su
authors.initials: BS
authors.lastname: Kim
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry*; D002460:Cell Line; D002470:Cell Survival; D016503:Drug Delivery Systems; D005990:Glycerol / Q000138:chemical synthesis / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D008027:Light; D008823:Micelles; D015394:Molecular Structure; D009574:Nitro Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001578:Benzopyrans; D007211:Indoles; D008823:Micelles; D009574:Nitro Compounds; D011108:Polymers; C088184:spiropyran; C043941:polyglycerol; D005990:Glycerol