title: Intestinal T-cell lymphomas: a retrospective analysis of 68 cases in China.
abstract: OBJECTIVE
  To investigate the clinical features, diagnosis, treatment and prognosis of intestinal T-cell lymphomas (ITCL) by retrospective analysis.
  
  
  METHODS
  Sixty-eight patients who were diagnosed with ITCL in case reports in the Chinese literature were compiled and reviewed. Age, gender, CD56 expression, surgical management, multifocal nature, perforation and cyclophosphamide chemotherapy were analyzed as the prognostic factors. The Kaplan-Meier method was adopted for the univariate analysis and the cumulative survival curve analysis.
  
  
  RESULTS
  The male-to-female ratio was 1.52 to 1. The median age was 41.7 years. Twenty-seven patients had symptoms of abdominal pain or diarrhea. Thirty-six of 60 patients with temperature records had high fevers at the onset of the illness. Twenty-six of 34 patients who underwent fiberoptic colonoscopy were misdiagnosed with Crohn's disease, intestinal tuberculosis or cancer. Sixty-one patients underwent surgery. Twelve of 61 surgical patients required a second operation for anastomotic leakage or secondary perforation. The sites of lesion involvement were the jejunum (8.82%), ileum (29.41%), ileum and colon (4.41%), colon (55.88%) and appendix (1.47%). The median cumulative survival rate was 3 mo (3.00 ± 0.48).
  
  
  CONCLUSIONS
  Efforts should be made to correctly diagnose ITCL and select the proper operative approach that may reduce serious complications and create opportunities for further treatment.
authors.affiliation: Zhi-Huan Sun, Hai-Meng Zhou, Guo-Xin Song, Zhong-Xiao Zhou, Liang Bai, Department of Surgery, Weihai Municipal Hospital, Binzhou Medical College Affiliated Hospital, Weihai 264200, Shandong Province, China.
authors.forename: Zhi-Huan
authors.initials: ZH
authors.lastname: Sun
authors.affiliation: Zhi-Huan Sun, Hai-Meng Zhou, Guo-Xin Song, Zhong-Xiao Zhou, Liang Bai, Department of Surgery, Weihai Municipal Hospital, Binzhou Medical College Affiliated Hospital, Weihai 264200, Shandong Province, China.
authors.forename: Hai-Meng
authors.initials: HM
authors.lastname: Zhou
authors.affiliation: Zhi-Huan Sun, Hai-Meng Zhou, Guo-Xin Song, Zhong-Xiao Zhou, Liang Bai, Department of Surgery, Weihai Municipal Hospital, Binzhou Medical College Affiliated Hospital, Weihai 264200, Shandong Province, China.
authors.forename: Guo-Xin
authors.initials: GX
authors.lastname: Song
authors.affiliation: Zhi-Huan Sun, Hai-Meng Zhou, Guo-Xin Song, Zhong-Xiao Zhou, Liang Bai, Department of Surgery, Weihai Municipal Hospital, Binzhou Medical College Affiliated Hospital, Weihai 264200, Shandong Province, China.
authors.forename: Zhong-Xiao
authors.initials: ZX
authors.lastname: Zhou
authors.affiliation: Zhi-Huan Sun, Hai-Meng Zhou, Guo-Xin Song, Zhong-Xiao Zhou, Liang Bai, Department of Surgery, Weihai Municipal Hospital, Binzhou Medical College Affiliated Hospital, Weihai 264200, Shandong Province, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Bai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D017024:Chemotherapy, Adjuvant; D002681:China; D003113:Colonoscopy; D003951:Diagnostic Errors; D013505:Digestive System Surgical Procedures / Q000009:adverse effects; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy; D053208:Kaplan-Meier Estimate; D054391:Lymphoma, Extranodal NK-T-Cell / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000401:mortality / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000601:surgery; D011237:Predictive Value of Tests; D012086:Reoperation; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D019002:CD56 Antigen; C522918:NCAM1 protein, human
keywords: Enteropathy-associated T-cell lymphoma; Enterostomy; Intestinal T-cell lymphoma; Intestinal perforation; NK/T-cell lymphoma