title: Association of antinociceptive action of botulinum toxin type A with GABA-A receptor.
abstract: The mechanism of botulinum toxin type A (BTX-A) antinociceptive action in the central nervous system is little known. The potential interaction between BTX-A and GABAergic system has not been investigated previously. In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A.
authors.affiliation: Department of Pharmacology, University of Zagreb Faculty of Pharmacy and Biochemistry, Domagojeva 2, 10000, Zagreb, Croatia, vdrinovac@pharma.hr.
authors.forename: V
authors.initials: V
authors.lastname: Drinovac
authors.forename: L
authors.initials: L
authors.lastname: Bach-Rojecky
authors.forename: Z
authors.initials: Z
authors.lastname: Lacković
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004333:Drug Administration Routes; D005557:Formaldehyde / Q000633:toxicity; D006930:Hyperalgesia / Q000188:drug therapy; D009498:Neurotoxins / Q000627:therapeutic use*; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000378:metabolism*; D012585:Sciatica / Q000517:prevention & control*
chemical_list: D009498:Neurotoxins; D016760:Proto-Oncogene Proteins c-fos; D011963:Receptors, GABA-A; D005557:Formaldehyde; D019274:Botulinum Toxins, Type A; D001640:Bicuculline