title: Mind the gap: Management of an emergent and threatening invasive fungal infection-a case report of rhino-orbital-cerebral and pulmonary mucormycosis.
abstract: Mucormycosis is an emergent and threatening invasive fungal invasion underdiagnosed by clinicians due to lack of awareness and aspecific clinical picture. The authors describe a clinical case of a diabetic and cirrhotic patient who developed rhino-orbital-cerebral and pulmonary mucormycosis, non-responsive to treatment. Typical gaps in the management of this deadly disease are addressed. There is a strong need for novel therapies and an expectation that sponsors will recognize the critical need for randomized clinical trials.
authors.affiliation: Infectious Diseases Department, Coimbra's Hospital Centre and University (Centro Hospitalar e Universitário de Coimbra), General Hospital, Coimbra 3041-801, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Cortez
authors.affiliation: Neuroradiology Department, Coimbra's Hospital Centre and University (Centro Hospitalar e Universitário de Coimbra), General Hospital, Coimbra 3041-801, Portugal.
authors.forename: Bruno Costa
authors.initials: BC
authors.lastname: Gomes
authors.affiliation: Infectious Diseases Department, Coimbra's Hospital Centre and University (Centro Hospitalar e Universitário de Coimbra), General Hospital, Coimbra 3041-801, Portugal.
authors.forename: Andrea
authors.initials: A
authors.lastname: Speidel
authors.affiliation: Otorhinolaringology Department, Coimbra's Hospital Centre and University (Centro Hospitalar e Universitário de Coimbra), General Hospital, Coimbra 3041-801, Portugal.
authors.forename: Conceição
authors.initials: C
authors.lastname: Peixoto
authors.affiliation: Infectious Diseases Department, Riga Eastern Clinical University Hospital, Infectology Centre of Latvia, Riga, Latvia.
authors.forename: Elina
authors.initials: E
authors.lastname: Selicka
authors.affiliation: Infectious Diseases Department, Coimbra's Hospital Centre and University (Centro Hospitalar e Universitário de Coimbra), General Hospital, Coimbra 3041-801, Portugal.
authors.forename: Cristina
authors.initials: C
authors.lastname: Valente
authors.affiliation: Pathology Department, Portuguese Oncology Institute (Instituto Português de Oncologia), Coimbra 3000-075, Portugal.
authors.forename: Paulo
authors.initials: P
authors.lastname: Figueiredo
authors.affiliation: Infectious Diseases Department, Coimbra's Hospital Centre and University (Centro Hospitalar e Universitário de Coimbra), General Hospital, Coimbra 3041-801, Portugal.
authors.forename: António
authors.initials: A
authors.lastname: Vieira
keywords: Delays; Diabetes; High mortality; Hyperbaric medicine; Mucormycosis; Randomized clinical trials