title: Preliminary research on a novel bioactive silicon doped calcium phosphate coating on AZ31 magnesium alloy via electrodeposition.
abstract: A silicon doped calcium phosphate coating was obtained successfully on AZ31 alloy substrate via pulse electrodeposition. A novel dual-layer structure was observed with a porous lamellar-like and outer block-like apatite layer. In vitro immersion tests were adopted in simulated body fluid within 28 days of immersion. Slow degradation rate obtained from weight loss was observed for the Si-doped Ca-P coating, which was also consistent with the results of electrochemical experiments showing an enhanced corrosion resistance for the coating. Further formation of an apatite-like layer on the surface after immersion proved better integrity and biomineralization performance of the coating. Biological characterization was carried out for viability, proliferation and differentiation of MG63 osteoblast-like cells. The coating showed a good cell growth and an enhanced cell proliferation. Moreover, an increased activity of osteogenic marker ALP was found. All the results demonstrated that the Si-doped calcium phosphate was perspective to be used as a coating for magnesium alloy implants to control the degradation rate and enhance the bioactivity, which would facilitate the rapidity of bone tissue repair.
authors.affiliation: Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China; Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Qiu
authors.affiliation: Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China. Electronic address: pwan@imr.ac.cn.
authors.forename: Peng
authors.initials: P
authors.lastname: Wan
authors.affiliation: Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Tan
authors.affiliation: Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
authors.forename: Xinmin
authors.initials: X
authors.lastname: Fan
authors.affiliation: Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000497:Alloys / Q000494:pharmacology*; D002130:Calcium Phosphates / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D048430:Cell Shape / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D003343:Corrosion; D004560:Electricity; D055664:Electrochemical Techniques; D004595:Electroplating / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008903:Minerals / Q000737:chemistry; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D012825:Silicon / Q000494:pharmacology*; D013052:Spectrometry, X-Ray Emission; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C586533:Mg-Al-Zn-Mn-Si-Cu alloy; D008903:Minerals; C020243:calcium phosphate; D000469:Alkaline Phosphatase; D012825:Silicon
keywords: AZ31 magnesium alloy; Bioactive; Biodegradable; Calcium phosphate coating; Pulse electrodeposition; Silicon