title: Risk of cervical HPV infection and prevalence of vaccine-type and other high-risk HPV types among sexually active teens and young women (13-26 years) enrolled in the VALHIDATE study.
abstract: HPV vaccination is expected to reduce the incidence of cervical cancer. The greatest and the earliest health gains will be ensured by high vaccine coverage among all susceptible people. The high costs and the risk of a reduced cost/effectiveness ratio in sexually active girls still represent the main obstacles for a more widespread use of HPV vaccination in many countries. Data on the rate, risk factors, and HPV types in sexually active women could provide information for the evaluation of vaccination policies extended to broader age cohorts. Sexually active women aged 13-26 years enrolled in an Italian cohort study were screened for cervical HPV infections; HPV-DNA positive samples were genotyped by InnoLipa HPV Genotyping Extra or by RFLP genotype analysis.: Among the 796 women meeting the inclusion criteria, 10.80% (95% CI 8.65-12.96) were HPV-DNA infected. Age>18 years, lifetime sexual partners>1, and history of STIs were associated to higher risk of HPV infection in the multivariable models adjusted for age, lifetime sexual partners, and time of sexual exposure. The global prevalence of the four HPV vaccine-types was 3.02% (95% CI 1.83-4.20) and the cumulative probability of infection from at least one vaccine-type was 12.82% in 26-years-old women and 0.78% in 18-years-old women.: Our data confirm most of the previously reported findings on the risk factors for HPV infections. The low prevalence of the HPV vaccine-types found may be useful for the evaluation of the cost/efficacy and the cost/effectiveness of broader immunization programs beyond the 12-years-old cohort.
authors.affiliation: STD Unit; Infectious Diseases I; L Sacco University Hospital; Milan, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Orlando
authors.affiliation: STD Unit; Infectious Diseases I; L Sacco University Hospital; Milan, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Fasolo
authors.affiliation: STD Unit; Infectious Diseases I; L Sacco University Hospital; Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Mazza
authors.affiliation: Infectious Diseases I; L Sacco University Hospital; Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Ricci
authors.affiliation: Pediatric Clinic I; Department of Pathophysiology and Transplantation; University of Milan; Milan, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Esposito
authors.affiliation: Department of Biomedical Sciences for Health; University of Milan; Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Frati
authors.affiliation: Pediatric Unit; L Sacco University Hospital; Milan, Italy.
authors.forename: Gian Vincenzo
authors.initials: GV
authors.lastname: Zuccotti
authors.affiliation: Gynaecology Unit; L Sacco University Hospital; Milan, Italy.
authors.forename: Irene
authors.initials: I
authors.lastname: Cetin
authors.affiliation: Unità Organizzativa Governo della Prevenzione e Tutela Sanitaria; Direzione Generale Sanità; Regione Lombardia; Milan, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Gramegna
authors.affiliation: Infectious Diseases I; L Sacco University Hospital; Milan, Italy.
authors.forename: Giuliano
authors.initials: G
authors.lastname: Rizzardini
authors.affiliation: Department of Biomedical Sciences for Health; University of Milan; Milan, Italy.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Tanzi
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D007558:Italy / Q000453:epidemiology; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D053918:Papillomavirus Vaccines / Q000276:immunology*; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D053918:Papillomavirus Vaccines
keywords: HPV infection; HPV vaccine; HR-HPV; risk factors; sexually active girls