title: Long-term immune responses to vaccination in HIV-infected patients: a systematic review and meta-analysis.
abstract: Vaccine-induced antibodies may wane more quickly in persons living with human immunodeficiency virus (HIV) than in healthy individuals. We reviewed the literature on vaccines routinely recommended in HIV-infected patients to estimate how seroprotection decreases over time in those who initially responded to immunization. For each study retrieved from the literature, the decrease of seroprotection was modeled with a log binomial generalized linear model, and data were pooled in a meta-analysis to provide estimates of seroprotection 2 and 5 years after the last vaccine administration. Our analyses confirmed that the duration of seroprotection was shorter in HIV-infected patients and that with current guidelines, a substantial proportion of patients would have lost protective antibodies before a booster was proposed. We therefore discuss the implications for the monitoring of antibody levels and timing of revaccination in these patients.
authors.affiliation: Paris Descartes University.
authors.forename: Solen
authors.initials: S
authors.lastname: Kernéis
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
authors.forename: Clément
authors.initials: C
authors.lastname: Turbelin
authors.forename: Frédéric
authors.initials: F
authors.lastname: Batteux
authors.forename: Thomas
authors.initials: T
authors.lastname: Hanslik
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Boëlle
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007223:Infant; D015233:Models, Statistical; D013997:Time Factors; D014611:Vaccination / Q000379:methods*; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D055815:Young Adult
chemical_list: D014612:Vaccines
keywords: HIV; meta-analysis; vaccination