title: Improvement of type 2 diabetes mellitus after gastric cancer surgery: short-term outcome analysis after gastrectomy.
abstract: OBJECTIVE
  To evaluate the effect of gastrectomy on diabetes control in patients with type 2 diabetes mellitus and early gastric cancer.
  
  
  METHODS
  Data from 64 patients with early gastric cancer and type 2 diabetes mellitus were prospectively collected. All patients underwent curative gastrectomy (36 subtotal gastrectomy with gastroduodenostomy, 16 subtotal gastrectomy with gastrojejunostomy, 12 total gastrectomy) and their physical and laboratory data were evaluated before and 3, 6 and 12 mo after surgery.
  
  
  RESULTS
  Fasting blood glucose (FBS), HbA1c, insulin, C-peptide, and homeostasis model assessment-estimated insulin resistance were significantly improved 3 mo after surgery, regardless of operation type, and the significant improvement in all measured values, except HbA1c, was sustained up to 12 mo postoperatively. Approximately 3.1% of patients stopped diabetes medication and had HbA1c < 6.0% and FBS < 126 mg/dL. 54.7% of patients decreased their medication, and had reduced FBS or HbA1c. In multivariate analysis, good diabetic control was not associated with operation type, but was associated with diabetes duration.
  
  
  CONCLUSIONS
  Diabetes improved in more than 50% of patients during the first year after gastric cancer surgery. The degree of diabetes control was related to diabetes duration.
authors.affiliation: Ji Yeong An, Min Ah Yun, Sung Hoon Noh, Department of Surgery, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, South Korea.
authors.forename: Ji Yeong
authors.initials: JY
authors.lastname: An
authors.affiliation: Ji Yeong An, Min Ah Yun, Sung Hoon Noh, Department of Surgery, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, South Korea.
authors.forename: Yoo Min
authors.initials: YM
authors.lastname: Kim
authors.affiliation: Ji Yeong An, Min Ah Yun, Sung Hoon Noh, Department of Surgery, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, South Korea.
authors.forename: Min Ah
authors.initials: MA
authors.lastname: Yun
authors.affiliation: Ji Yeong An, Min Ah Yun, Sung Hoon Noh, Department of Surgery, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, South Korea.
authors.forename: Byeong Hee
authors.initials: BH
authors.lastname: Jeon
authors.affiliation: Ji Yeong An, Min Ah Yun, Sung Hoon Noh, Department of Surgery, Yonsei University College of Medicine, Seodaemun-gu, Seoul 120-752, South Korea.
authors.forename: Sung Hoon
authors.initials: SH
authors.lastname: Noh
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D016009:Chi-Square Distribution; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000175:diagnosis; D004385:Duodenostomy; D005215:Fasting / Q000097:blood; D005260:Female; D005743:Gastrectomy; D015390:Gastric Bypass; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; C517652:hemoglobin A1c protein, human
keywords: Gastrectomy; Gastric cancer; Glucose control; Short-term outcome; Type 2 diabetes mellitus