title: Exosomes and cardiac repair after myocardial infarction.
abstract: Myocardial infarction is a leading cause of death among all cardiovascular diseases. The analysis of molecular mechanisms by which the ischemic myocardium initiates repair and remodeling indicates that secreted soluble factors are key players in communication to local and distant tissues, such as bone marrow. Recently, actively secreted membrane vesicles, including exosomes, are being recognized as new candidates with important roles in intercellular and tissue-level communication. In this review, we critically examine the emerging role of exosomes in local and distant microcommunication mechanisms after myocardial infarction. A comprehensive understanding of the role of exosomes in cardiac repair after myocardial infarction could bridge a major gap in knowledge of the repair mechanism after myocardial injury.
authors.affiliation: From Feinberg Cardiovascular Research Institute, Chicago, IL (S.S., D.W.L.); Northwestern Memorial Hospital, Chicago, IL (D.W.L.); and NeoStem, Inc, New York, NY (D.W.L.).
authors.forename: Susmita
authors.initials: S
authors.lastname: Sahoo
authors.forename: Douglas W
authors.initials: DW
authors.lastname: Losordo
mesh_terms: D000818:Animals; D002450:Cell Communication; D055354:Exosomes / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism; D012038:Regeneration; D015398:Signal Transduction; D033581:Stem Cell Transplantation
chemical_list: D012333:RNA, Messenger
keywords: adult stem cells; exosomes; microRNAs; multivesicular bodies; myocardial infarction; progenitor cells