title: Photosensitivity, apoptosis, and cytokines in the pathogenesis of lupus erythematosus: a critical review.
abstract: The underlying pathomechanisms of lupus erythematosus (LE), a multifactorial autoimmune disease, remain elusive. Due to the clinical evidence demonstrating a clear relationship between ultraviolet (UV) light exposure and skin lesions of LE, photosensitivity has been proven to be an important factor in the pathogenesis of the disease. Standardised photoprovocation with UVA and UVB irradiation has been shown to be a reliable model for evaluating photosensitivity in patients with cutaneous LE (CLE) and analysing the underlying medical conditions of the disease. In this respect, UV irradiation can cause aberrant induction of apoptosis in keratinocytes and contribute to the appearance of excessive apoptotic cells in the skin of CLE patients. Moreover, apoptotic cells that cannot be cleared by phagocytes may undergo secondary necrosis and release proinflammatory compounds and potential autoantigens, which may contribute to the inflammatory micromilieu that leads to formation of skin lesions in the disease. In addition to UV-mediated induction of apoptosis, the molecular and cellular factors that may cause the abnormal long-lasting photoreactivity in CLE include mediators of inflammation, such as cytokines and chemokines. In particular, interferons (IFNs) are important players in the early activation of the immune system and have a specific role in the immunological interface between the innate and the adaptive immune system. The fact that treatment with recombinant type I IFNs (α and β) can induce not only systemic organ manifestations but also LE-like skin lesions provides additional evidence for a pathogenetic role of these IFNs in the disease.
authors.affiliation: Department of Dermatology, University of Muenster, Von-Esmarch-Strasse 58, 48149, Muenster, Germany, kuhnan@uni-muenster.de.
authors.forename: Annegret
authors.initials: A
authors.lastname: Kuhn
authors.forename: Jörg
authors.initials: J
authors.lastname: Wenzel
authors.forename: Heiko
authors.initials: H
authors.lastname: Weyd
mesh_terms: D056704:Adaptive Immunity; D017209:Apoptosis; D001324:Autoantigens / Q000276:immunology; D018925:Chemokines / Q000235:genetics / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000235:genetics / Q000276:immunology*; D015603:Keratinocytes / Q000276:immunology* / Q000473:pathology; D008178:Lupus Erythematosus, Cutaneous / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D010787:Photosensitivity Disorders / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015398:Signal Transduction; D012867:Skin / Q000276:immunology* / Q000473:pathology; D014466:Ultraviolet Rays
chemical_list: D001324:Autoantigens; D018925:Chemokines; D007370:Interferon Type I