title: Protective effect of penehvclidine hvdrochloride on ischemia-reperfusion injury in rats.
abstract: OBJECTIVE
  To investigate the protective effect of penehvclidine hvdrochloride on ischemia-reperfusion injury in rats.
  
  
  METHODS
  The model of ischemia-reperfusion injury was established in rats through clamping rental pedicles for 50 min followed by reperfusion. A total of 60 Wistar rats were randomly divided into 4 groups including fake surgery group, model group, low PHC dosage group and high dosage penehvclidine hvdrochloride (PHC) group. Seven days before the experiment, rats in fake surgery group and model group were given 10 mL/kg normal saline, while rats in low PHC dosage group and high dosage PHC group were given 200 and 50 mg/kg PHC, respectively. The urine volume, diet volume, Cre, PU, BUN, IL-6, IL-8, TNF-α, NO MDA concentration, SOD and GSH-Px were determined.
  
  
  RESULTS
  Compared with rats in model group, decreased urine volume, diet volume, Cre, PU, BUN, IL-6, IL-8, TNF-α, NO MDA concentration and increased SOD and GSH-Px activity could be seen in low PHC dosage group and high dosage PHC group (P<0.05).
  
  
  CONCLUSIONS
  Administration of PHC before ischemia-reperfusion injury can help protect ischemia-reperfusion injury.
authors.affiliation: Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical Unversity, Huai'an Jiangsu 223300, P.R. China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Su
authors.affiliation: Department of Orthopedics, Huai'an First People's Hospital, Nanjing Medical Unversity, Huai'an Jiangsu 223300, P.R. China. Electronic address: 1398549178@qq.com.
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood; D005260:Female; D007249:Inflammation; D007668:Kidney / Q000737:chemistry; D018384:Oxidative Stress / Q000187:drug effects; D020011:Protective Agents / Q000494:pharmacology*; D011812:Quinuclidines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D016207:Cytokines; D020011:Protective Agents; D011812:Quinuclidines; C486140:penehyclidine
keywords: Inflammation factor; Penehvclidine hvdrochloride; Radical; Rental ischemia-reperfusion injury