title: Multicopper oxidases: intramolecular electron transfer and O2 reduction.
abstract: The multicopper oxidases are an intriguing, widespread family of enzymes that catalyze the reduction of O2 to water by a variety of single-electron and multiple-electron reducing agents. The structure and properties of the copper binding sites responsible for the latter chemical transformations have been studied for over 40 years and a detailed picture is emerging. This review focuses particularly on the kinetics of internal electron transfer between the type 1 (blue) copper site and the trinuclear center, as well as on the nature of the intermediates formed in the oxygen reduction process.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, WA, 99164-4630, USA, scot_wherland@wsu.edu.
authors.forename: Scot
authors.initials: S
authors.lastname: Wherland
authors.forename: Ole
authors.initials: O
authors.lastname: Farver
authors.forename: Israel
authors.initials: I
authors.lastname: Pecht
mesh_terms: D003300:Copper / Q000378:metabolism; D004579:Electron Transport / Q000502:physiology; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*
chemical_list: D003300:Copper; D010088:Oxidoreductases; D010100:Oxygen