title: Repair of large full-thickness cartilage defect by activating endogenous peripheral blood stem cells and autologous periosteum flap transplantation combined with patellofemoral realignment.
abstract: Minimal-invasive procedure and one-step surgery offer autologous mesenchymal stem cells derived from peripheral blood (PB-MSCs) a promising prospective in the field of cartilage regeneration. We report a case of a 19-year-old male athlete of kickboxing with ICRS grade IV chondral lesions at the 60° region of lateral femoral trochlea, which was repaired by activating endogenous PB-MSCs plus autologous periosteum flap transplantation combined with correcting the patellofemoral malalignment. After a 7.5 year follow-up, the result showed that the patient returned to competitive kickboxing. Second-look under arthroscopy showed a smooth surface at 8 months postoperation. The IKDC 2000 subjective score, Lysholm score and Tegner score were 95, 98 and 9 respectively at the final follow up. CT and MRI evaluations showed a significant improvement compared with those of pre-operation.
authors.affiliation: Institute of Sports Medicine, Peking University Third Hospital, PR China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Fu
authors.affiliation: Institute of Sports Medicine, Peking University Third Hospital, PR China.
authors.forename: Ying-Fang
authors.initials: YF
authors.lastname: Ao
authors.affiliation: Department of Hematology and Lymphoma Research Center, Peking University Third Hospital, PR China.
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Ke
authors.affiliation: Department of Diagnostic Radiology, Peking University Third Hospital, PR China.
authors.forename: Zhuo-Zhao
authors.initials: ZZ
authors.lastname: Zheng
authors.affiliation: Institute of Sports Medicine, Peking University Third Hospital, PR China.
authors.forename: Xi
authors.initials: X
authors.lastname: Gong
authors.affiliation: Institute of Sports Medicine, Peking University Third Hospital, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Jiang
authors.affiliation: Institute of Sports Medicine, Peking University Third Hospital, PR China. Electronic address: yujiakuo@126.com.
authors.forename: Jia-Kuo
authors.initials: JK
authors.lastname: Yu
mesh_terms: D001182:Arthroscopy; D017760:Bone Malalignment / Q000601:surgery*; D002358:Cartilage, Articular / Q000293:injuries / Q000502:physiology / Q000601:surgery*; D006801:Humans; D007718:Knee Injuries / Q000601:surgery; D008297:Male; D057071:Patellofemoral Joint / Q000601:surgery*; D010521:Periosteum / Q000637:transplantation*; D036102:Peripheral Blood Stem Cell Transplantation; D012038:Regeneration; D013977:Tibia / Q000637:transplantation*; D014182:Transplantation, Autologous; D055815:Young Adult
keywords: Cartilage defect; Mesenchymal stem cells; Patellofemoral realignment; Periosteum transplantation