title: RNA granule component TDRD7 gene polymorphisms in a Han Chinese population with age-related cataract.
abstract: OBJECTIVE
  To examine whether polymorphisms in the RNA granule component tudor domain-containing protein 7 (TDRD7) gene are associated with susceptibility to age-related cataract (ARC) in a Han Chinese population.
  
  
  METHODS
  Patients with ARC, and age-, sex- and ethnically-matched healthy control subjects were enrolled in the study. Five single nucleotide polymorphisms (SNPs) within the TDRD7 gene, rs1462091, rs11793735, rs10981985, rs2045732 and rs1462089, were genotyped using a SNaPshot® Multiplex Kit.
  
  
  RESULTS
  The study included 271 control subjects and 218 patients with ARC. The rs10981985 SNP was associated with ARC in dominant (odds ratio [OR] 0.561, 95% confidence interval [CI] 0.388, 0.809) and allele dose (OR 0.619, 95% CI 0.455, 0.841) genetic models. The rs10981985 A allele frequency was lower in patients with cortical ARC than in control subjects (OR 0.502, 95% CI 0.315, 0.801). The rs10981985 polymorphism was significantly associated with cortical ARC in a dominant genetic model (OR 0.431, 95% CI 0.251, 0.740).
  
  
  CONCLUSIONS
  The present study suggests that the rs10981985 G → A variant within the TDRD7 gene may protect against cortical ARC in a Han Chinese population.
authors.affiliation: Department of Ophthalmology, Research Institute of Field Surgery, Da Ping Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Can
authors.initials: C
authors.lastname: Zheng
authors.forename: Min
authors.initials: M
authors.lastname: Wu
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: He
authors.forename: Xiao-Ju
authors.initials: XJ
authors.lastname: An
authors.forename: Min
authors.initials: M
authors.lastname: Sun
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Chen
authors.forename: Jian
authors.initials: J
authors.lastname: Ye
mesh_terms: D000368:Aged; D000375:Aging / Q000235:genetics; D001483:Base Sequence; D016022:Case-Control Studies; D002386:Cataract / Q000235:genetics*; D002681:China; D017931:DNA Primers; D005006:Ethnicity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012313:RNA / Q000235:genetics*; D012261:Ribonucleoproteins / Q000235:genetics*
chemical_list: D017931:DNA Primers; D012261:Ribonucleoproteins; C557201:Tdrd7 protein, human; D012313:RNA
keywords: Age-related cataract; RNA granules; single nucleotide polymorphism; tudor domain-containing protein 7