title: [The relationship between glycogen synthase kinase - 3beta -1727A/T x -50T/C genetic polymorphisms and nicotine dependence].
abstract: As a help of the mechanism elucidation of nicotine dependence, we studied the relationship between glycogen synthase kinase (GSK) - 3beta -1727A/T and -50T/C genetic polymorphisms, which are reported to be related to bipolar disorder. We genotyped the two polymorphisms in the GSK-3beta gene using a polymerase chain reaction (PCR) in 103 healthy controls (never smokers) and 71 smokers with FTND scores of 3 or above. There is no significant relationship between the polymorphism of GSK-3beta -1727A/T and the nicotine addicts. However, it was shown that GSK-3beta -50T/C polymorphism was significantly associated with the nicotine dependence. There was significantly lower T-allele frequency in the smokers than controls (chi2 (2) = 23.42, P = 0.01; chi2 (1) = 12.17, P = 0.01).
authors.affiliation: Laboratory of Neurophysiology, the Graduate School of Environmental Health Sciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Numajiri
authors.affiliation: Research Project for Addictive Substances, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Toukyo 156-8506, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nishizawa
authors.affiliation: Research Project for Addictive Substances, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Toukyo 156-8506, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ikeda
authors.affiliation: Laboratory of Neurophysiology, the Graduate School of Environmental Health Sciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Yoshihara
authors.affiliation: Laboratory of Neurophysiology, the Graduate School of Environmental Health Sciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Iwahashii
mesh_terms: D000328:Adult; D005260:Female; D005838:Genotype; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014029:Tobacco Use Disorder / Q000235:genetics*; D055815:Young Adult
chemical_list: D038362:Glycogen Synthase Kinase 3