title: Measurement of scleral thickness using swept-source optical coherence tomography in patients with open-angle glaucoma and myopia.
abstract: OBJECTIVE
  To use swept-source optical coherence tomography (OCT) to image the posterior sclera at the posterior pole and around the optic nerve head (ONH) and measure the subfoveal scleral thickness and laminar thickness to evaluate the relationship between the measured thicknesses and ocular parameters.
  
  
  METHODS
  Prospective, cross-sectional design.
  
  
  METHODS
  The study included 103 patients with glaucoma and 43 controls with axial lengths more than 26 mm. Swept-source OCT images were obtained to capture the subfoveal and ONH regions. Subfoveal scleral thickness and laminar thickness were measured from obtained B-scan images. To verify the reproducibility of the measurement, intraclass correlation coefficients were calculated from selected B-scans. Scleral and laminar thicknesses in patients with normal-tension glaucoma (NTG) was compared with that in patients with primary open-angle glaucoma (POAG). A Pearson correlation was calculated to assess the relationships of scleral and laminar thicknesses with ocular parameters.
  
  
  RESULTS
  Posterior scleral thickness could be measured in 68.4% of patients, and laminar thickness could be measured in 88.6% by using swept-source OCT. Interobserver and intraobserver measurement reproducibility was moderate to excellent. The subfoveal scleral thickness was 670.84 ± 160.60 μm in the POAG group and 496.55 ± 115.20 μm in the NTG group; a significant difference between the groups was observed. Subfoveal scleral thickness (r = -0.677, P < 0.001) was negatively correlated with axial length only in patients with NTG, not in patients with POAG.
  
  
  CONCLUSIONS
  Swept-source OCT detected differences in the thicknesses of the posterior sclera between eyes with NTG and eyes with POAG. Subfoveal scleral thickness was negatively correlated with axial length only in eyes with NTG.
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Hae-Young
authors.initials: HY
authors.lastname: Lopilly Park
authors.affiliation: Incheon St. Mary's Hospital, Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Incheon, South Korea.
authors.forename: Na Young
authors.initials: NY
authors.lastname: Lee
authors.affiliation: St. Vincent Hospital, Department of Ophthalmology, College of Medicine, The Catholic University of Korea, Suwon, South Korea.
authors.forename: Jin A
authors.initials: JA
authors.lastname: Choi
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. Electronic address: ckpark@catholic.ac.kr.
authors.forename: Chan Kee
authors.initials: CK
authors.lastname: Park
mesh_terms: D003430:Cross-Sectional Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D057066:Low Tension Glaucoma / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000175:diagnosis*; D015588:Observer Variation; D009898:Optic Disk / Q000473:pathology; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D009929:Organ Size; D011446:Prospective Studies; D015203:Reproducibility of Results; D012590:Sclera / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000379:methods*