title: Photocrosslinkable bioadhesive based on dextran and PEG derivatives.
abstract: In this study, a hybrid photopolymeric bioadhesive system consisting of urethane methacrylated dextran (Dex-U) and 3, 4-Dihydroxyphenyl-l-alanine (DOPA) modified three-arm poly (ethylene glycol) s (PEG-DOPAs) was designed. The process of photopolymerization was detected by Photo-Differential Scanning Calorimetry (Photo-DSC). The adhesion strength was evaluated by the lap shear tests. The surface tension of the solutions, burst pressures and the cytotoxicity assays were also investigated. The addition of PEG-DOPAs significantly improved the properties of Dex-U especially in the field of adhesion strength and burst pressure. And materials variation could be tailored to match the demands for tissue repair. Compared to the Dex-U systems, the maximum adhesion strength of the copolymeric system increased from 2.7±0.1 MPa to 4.0±0.6 MPa. Owing to its strong adhesion strength, rapid curing rate and good biocompatibility, such photocrosslinkable hydrogelsa could be applied to the areas of bioadhesive.
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, State Key Laboratory of Chemical Resource Engineering, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, State Key Laboratory of Chemical Resource Engineering, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, State Key Laboratory of Chemical Resource Engineering, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Lihui
authors.initials: L
authors.lastname: Hu
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, State Key Laboratory of Chemical Resource Engineering, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Yaohua
authors.initials: Y
authors.lastname: Wei
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, State Key Laboratory of Chemical Resource Engineering, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Jianning
authors.initials: J
authors.lastname: Liu
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, State Key Laboratory of Chemical Resource Engineering, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Xueyan
authors.initials: X
authors.lastname: Mu
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, State Key Laboratory of Chemical Resource Engineering, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Nie
authors.affiliation: Key Laboratory of Carbon Fiber and Functional Polymers, State Key Laboratory of Chemical Resource Engineering, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China. Electronic address: yangdz@mail.buct.edu.cn.
authors.forename: Dongzhi
authors.initials: D
authors.lastname: Yang
mesh_terms: D000268:Adhesiveness / Q000528:radiation effects; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000528:radiation effects; D003911:Dextrans / Q000737:chemistry* / Q000528:radiation effects; D006244:Hardness / Q000528:radiation effects; D008027:Light; D008422:Materials Testing; D010777:Photochemistry / Q000379:methods; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000528:radiation effects; D014014:Tissue Adhesives / Q000138:chemical synthesis* / Q000528:radiation effects
chemical_list: D003432:Cross-Linking Reagents; D003911:Dextrans; D014014:Tissue Adhesives; D011092:Polyethylene Glycols
keywords: Dextran; Dopamine hydrochloride; Photocrosslinking; Poly (ethylene glycol); Tissue adhesive