title: Diagnostic criteria for autoimmune neutropenia.
abstract: Autoimmune neutropenia denotes that the number of circulating polymorphonuclear neutrophils is below 1.5×10(9)/L. This encompasses a wide range of disorders from primary conditions to complications of systemic autoimmune diseases or hematological neoplasms. Antineutrophil autoantibodies are particularly difficult to detect, and their amount does not correlate with the degree of neutropenia. Granulocyte colony-stimulating factor is the first-line therapy, but should be restricted to patients with total absence of neutrophils and/or severe infections.
authors.affiliation: EA2216 Immunologie et Pathologie, LabEx IGO, SFR ScInBioS, Université de Brest et Université Européenne de Bretagne, Brest, France. Electronic address: youinou@univ-brest.fr.
authors.forename: Pierre
authors.initials: P
authors.lastname: Youinou
authors.affiliation: EA2216 Immunologie et Pathologie, LabEx IGO, SFR ScInBioS, Université de Brest et Université Européenne de Bretagne, Brest, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Jamin
authors.affiliation: EA2216 Immunologie et Pathologie, LabEx IGO, SFR ScInBioS, Université de Brest et Université Européenne de Bretagne, Brest, France.
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Le Pottier
authors.affiliation: EA2216 Immunologie et Pathologie, LabEx IGO, SFR ScInBioS, Université de Brest et Université Européenne de Bretagne, Brest, France.
authors.forename: Yves
authors.initials: Y
authors.lastname: Renaudineau
authors.affiliation: EA2216 Immunologie et Pathologie, LabEx IGO, SFR ScInBioS, Université de Brest et Université Européenne de Bretagne, Brest, France.
authors.forename: Sophie
authors.initials: S
authors.lastname: Hillion
authors.affiliation: EA2216 Immunologie et Pathologie, LabEx IGO, SFR ScInBioS, Université de Brest et Université Européenne de Bretagne, Brest, France.
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Pers
mesh_terms: D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D016179:Granulocyte Colony-Stimulating Factor; D006801:Humans; D009503:Neutropenia / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D009504:Neutrophils / Q000276:immunology / Q000473:pathology
chemical_list: D001323:Autoantibodies; D016179:Granulocyte Colony-Stimulating Factor
keywords: Autoantibody; Polymorphonuclear neutrophil