title: Changes in the duration and frequency of deviant stimuli engender different mismatch negativity patterns in temporal lobe epilepsy.
abstract: Mismatch negativity (MMN) is an event-related potential (ERP) component that reflects preattentive sensory memory functions. Previous research revealed that MMN is generated by distinct sources in the frontal and temporal lobes. Event-related potential abnormalities have been shown in the vicinity of seizure foci in epilepsy. Additionally, no published study has investigated the MMN in response to variations in both frequency and duration deviants in patients with temporal lobe epilepsy (TLE). The aims of this study were to compare MMN changes between the frontocentral sites and the mastoid sites and to compare MMNs related to deviant stimuli with different durations and frequencies in patients with TLE. We recorded MMNs elicited by duration and frequency changes of deviant stimuli from 15 patients with TLE and 15 healthy control subjects. We found that mean MMN amplitudes related to duration deviants were lower in patients with TLE at the mastoid sites relative to controls, whereas the MMN amplitudes at the frontocentral sites did not differ between the two groups. There were no MMN differences related to frequency deviants between TLE subjects and controls at the frontocentral sites or the mastoid sites. Mismatch negativity parameters related to duration deviants did not correlate with those related to deviant frequencies in the group with TLE. The present findings suggest selective impairments among multiple mismatch generators in TLE and suggest that processing of temporal information of auditory stimuli is selectively disturbed in TLE. Changes in MMN amplitudes related to duration deviants at the mastoid sites may represent deficits in time-dependent processing in TLE.
authors.affiliation: Department of Life Sciences and Bio-informatics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: y.hirose.16@gmail.com.
authors.forename: Yuka
authors.initials: Y
authors.lastname: Hirose
authors.affiliation: Department of Life Sciences and Bio-informatics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Hara Clinic, Kanagawa, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Hara
authors.affiliation: Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Miho
authors.initials: M
authors.lastname: Miyajima
authors.affiliation: Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Ayasa
authors.initials: A
authors.lastname: Matsuda
authors.affiliation: Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Maehara
authors.affiliation: Hara Clinic, Kanagawa, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Hara
authors.affiliation: Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Matsushima
authors.affiliation: Department of Life Sciences and Bio-informatics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Section of Liaison Psychiatry and Palliative Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan; Onda-Daini Hospital, Chiba, Japan.
authors.forename: Katsuya
authors.initials: K
authors.lastname: Ohta
authors.affiliation: Department of Life Sciences and Bio-informatics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Matsuura
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D001307:Auditory Perception / Q000502:physiology*; D016022:Case-Control Studies; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time; D013223:Statistics as Topic; D055815:Young Adult
keywords: Event-rerated potential (ERP); MMN; Mastoid; Mismatch positivity (MMP); Preattentive memory function; Temporal processing