title: Studies on the formation of O/W nano-emulsions, by low-energy emulsification method, suitable for cosmeceutical applications.
abstract: The formation of oil/water (O/W) nano-emulsions suitable for cosmeceutical application was studied. Nano-emulsions were prepared by using phase inversion composition (PIC) method, one of the low-energy emulsification methods. The process consist of stepwise water addition to oil/surfactant mixture, at T = 25°C. Caprylic/capric triglycerides (GTCC), propylene glycol dicaprylate/dicaprate (PC) and oleic acid (OA) were applied as an oil phase. Polysorbate 80 was used as the surfactant. Kinetic stability of the nano-emulsions was analyzed by measuring droplet size as a function of time for different oil/surfactant ratio. The particles size distribution was analyzed by means DLS measurement technique (Dynamic Light Scattering), using Zetasizer Nano ZS (Malvern Instruments, UK). One of triterpenoic acid, practically non-water soluble substance was selected as an active and incorporated into the stable formulation. The obtained results proved that the nanoemulsion NE-T80-GTCC-20:80 based on caprylic/capric triglycerides with the oil/surfactant ratio O/S = 2 0:80 and the droplet size r = 25 nm was the most stable one and additionally showed the highest solubilisation capacity for the triterpene.
authors.affiliation: Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland.
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Jaworska
authors.affiliation: Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland.
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Sikora
authors.affiliation: Faculty of Environmental Engineering, Institute of Water Supply and Environmental Protection, Cracow University of Technology, Kraków, Poland.
authors.forename: Michał
authors.initials: M
authors.lastname: Zielina
authors.affiliation: Faculty of Chemical Engineering and Technology, Institute of Organic Chemistry and Technology, Cracow University of Technology, Kraków, Poland.
authors.forename: Jan
authors.initials: J
authors.lastname: Ogonowski
mesh_terms: D002626:Chemistry, Pharmaceutical; D003358:Cosmetics; D004655:Emulsions / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry; D009821:Oils / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D003358:Cosmetics; D004655:Emulsions; D009821:Oils; D013501:Surface-Active Agents; D014867:Water; D011092:Polyethylene Glycols