title: [The effect of cerebrolysin on the regeneration of the peripheral nerve depending on the scheme of paraneural administration].
abstract: An experimental morphological study in 56 animals has been performed in order to analyze the effect of cerebrolysin on the dynamics and long-term results of peripheral nerve regeneration after the transection and microsurgical suturing depending on the scheme of the preparation of paraneural infusion. The regeneration process was evaluated after 2.5; 4; 6 and 12 months. There was a stimulating effect of the preparation on the regenerative growth and differentiation of nerve fiber axial cylinders, vascularization of the distal segment of regenerating nerve and the trophic condition of myelin-forming Schwann cells. When the preparation is used according to the prolonged scheme, the effect persists for up to 10.5 months after the end of paraneural injection course.
authors.affiliation: FGBU Rossiĭskiĭ nauchnyĭ tsentr "Vosstanovitel'naia travmatologiia i ortopediia" im. akad. G.A. Ilizarova Minzdrava Rossii, Kurgan.
authors.forename: N A
authors.initials: NA
authors.lastname: Shchudlo
authors.forename: M M
authors.initials: MM
authors.lastname: Shchudlo
authors.forename: I V
authors.initials: IV
authors.lastname: Borisova
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000502:physiology; D048708:Cell Growth Processes / Q000187:drug effects; D004285:Dogs; D036502:Infusions, Intralesional; D009416:Nerve Regeneration / Q000187:drug effects*; D012583:Schwann Cells / Q000502:physiology; D012584:Sciatic Nerve / Q000473:pathology / Q000502:physiology*
chemical_list: D000596:Amino Acids; C006952:cerebrolysin