title: [Experimental study on effect of rhizoma drynariae flavone on bone destruction of collagen inducted arthritis rat].
abstract: OBJECTIVE
  Through establishing the rat model of CIA to evaluate the effect and mechanism of Rhizoma Drynariae Flavone on bone destruction of CIA rat.
  
  
  METHODS
  Subcutaneous injection of bovine type II collagen was used to induce Wistar rats to fall ill, and then established the rat model of CIA. The rats whose inflammation scores reached to two points or above were randomly divided into four groups, and were treated accordingly. The effect of Rhizoma Drynariae Flavone on bone destruction was evaluated.
  
  
  RESULTS
  At 12 weeks after treatment, bone trabecular area percentage and bone trabecular number in Rhizoma Drynariae Flavone group, Rhizoma Drynariae Flavone-1/2 Etanercept group, Etanercept group was obviously higher than that of sterilization water group (P < 0.05); and the trabecular resolving power of these groups was obviously less than that of sterilization water group (P < 0.05).
  
  
  CONCLUSIONS
  Rhizoma Drynariae Flavone can obviously inhibit inflammation of joint bone destruction of CIA rats,the effect may be related with bone trabecular number reduction and trabecular resolving power increasing.
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Hua-Li
authors.initials: HL
authors.lastname: Gao
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Lian-Bo
authors.initials: LB
authors.lastname: Xiao
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Zi-Feng
authors.initials: ZF
authors.lastname: Zhang
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Gui-Lin
authors.initials: GL
authors.lastname: Ouyang
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Xin-Xing
authors.initials: XX
authors.lastname: Huang
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Ning-Li
authors.initials: NL
authors.lastname: Li
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Jun-Lin
authors.initials: JL
authors.lastname: Hu
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Huang
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Spinal Surgery, Guangzhua Integrated Traditional and Western Hospital Medical Hospital, Shanghai 200052, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D005260:Female; D047309:Flavones / Q000627:therapeutic use*; D029621:Polypodiaceae / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D047309:Flavones