title: Vanadium-catalyzed oxidative Strecker reaction: α-C-H cyanation ofpara-methoxyphenyl (PMP)-protected primary amines.
abstract: We describe an oxidative Strecker reaction that allows for direct cyanation ofpara-methoxyphenyl (PMP)-protected primary amines. A vanadium(V) complex was used as the catalyst and TBHP as the oxidant. The cyanation occurs at the α-C position bearing either an alkyl or an aromatic group. This method provides a direct access to α-aminonitrile from amines with one-carbon extension.
authors.affiliation: Division of Chemistry, Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhu
authors.affiliation: Division of Chemistry, Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038.
authors.forename: Ji-Bao
authors.initials: JB
authors.lastname: Xia
authors.affiliation: Division of Chemistry, Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038.
authors.forename: Chuo
authors.initials: C
authors.lastname: Chen
keywords: C–H cyanation; Oxidative Strecker reaction; Primary amine; Schiff base ligand; Vanadium catalyst