title: [Progress on neuroprotective effects of erythropoietin].
abstract: The function of erythropoietin (EPO) is recognized as a stimulator for proliferation of red blood cell (RBC), however,recent studies have showed that EPO and EPO-R are widely distributed in nervous system, which indicates that it may also have important functions in nervous system. Studies proved its neuroprotective effects, especially in ischemic-hypoxic nerve tissues. These effects are mainly activated through several signal transduction pathway downstream and multiple mechanisms are involved. As a neuroprotective factor, EPO has been investigated in the clinical studies, which may lead to the clinical application in the future.
authors.affiliation: Department of Neurology, The Second Affiliated Hospital,Medical College of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Haiqin
authors.initials: H
authors.lastname: Wu
mesh_terms: D004921:Erythropoietin / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009482:Neurophysiology; D018696:Neuroprotective Agents; D015398:Signal Transduction
chemical_list: D018696:Neuroprotective Agents; D004921:Erythropoietin