title: Epigenetics in 2013. DNA methylation and miRNA: key roles in systemic autoimmunity.
abstract: Several advances in 2013 have improved our understanding of how epigenetic mechanisms affect autoimmune disorders. Many new insights were made into the regulation of gene expression by DNA methylation in systemic lupus erythematosus. For rheumatoid arthritis, complex interrelationships between DNA methylation and microRNAs in regulating gene expression were described.
authors.affiliation: Ann Arbor Veterans Administration Medical Center, Department of Medicine, University of Michigan, 3007 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Richardson
authors.affiliation: Department of Rheumatology/Immunology, University of Michigan, 3007 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, USA.
authors.forename: Dipak R
authors.initials: DR
authors.lastname: Patel
mesh_terms: D015551:Autoimmunity / Q000502:physiology*; D019175:DNA Methylation / Q000502:physiology*; D057890:Epigenomics; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D054648:Protein Phosphatase 2 / Q000502:physiology
chemical_list: D035683:MicroRNAs; D054648:Protein Phosphatase 2