title: RhoC involved in the migration of neural stem/progenitor cells.
abstract: Alzheimer's disease (AD) is characterized by deposition of beta-amyloid peptides (Aβ) and progressive loss of neurons. Neural stem/progenitor cells (NSPCs) can proliferate and produce immature neurons even in the brain of AD patients. However, Aβ42 significantly decreased the expression of RhoC in NSPCs during the co-incubation (P < 0.01). Treating with RhoC siRNA prevented membrane from protrusion and led to a significant reduction in cell migration in responses to SDF-1. Compared with wild-type mice, the numbers of RhoC-immunoreactive cells in hippocampus and cortex were significantly down-regulated in APP/PS1 mice aged 9 months. The results suggest that Aβ42 down-regulates the expression of RhoC in NSPCs in vitro and in vivo; down-regulated RhoC expression results in decreased migration of NSPCs.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, China.
authors.forename: Can
authors.initials: C
authors.lastname: Zhang
authors.forename: Xuemei
authors.initials: X
authors.lastname: Ge
authors.forename: Kenghoe
authors.initials: K
authors.lastname: Lok
authors.forename: Lu
authors.initials: L
authors.lastname: Zhao
authors.forename: Ming
authors.initials: M
authors.lastname: Yin
authors.forename: Ze-Jian
authors.initials: ZJ
authors.lastname: Wang
mesh_terms: D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D058953:Neural Stem Cells / Q000187:drug effects / Q000502:physiology*; D010446:Peptide Fragments / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D018631:ras Proteins / Q000096:biosynthesis* / Q000494:pharmacology; D000075024:rhoC GTP-Binding Protein
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C512911:Rhoc protein, mouse; D018631:ras Proteins; D000075024:rhoC GTP-Binding Protein