title: KI-catalyzed arylation of benzothiazoles from the coupling of aryl aldehydes with benzothiazoles in neat water.
abstract: A KI-catalyzed oxidative coupling of benzothiazoles with aryl aldehydes has been developed using TBHP as an oxidant in neat water under metal free conditions. Various 2-aryl benzothiazoles were prepared in 36-79% yields for 28 examples. The mechanistic studies suggested that this transformation proceeded via a radical process.
authors.affiliation: Engineering Research Center of Molecular Medicine, Ministry of Education, Key Laboratory of Xiamen Marine and Gene Drugs, Institutes of Molecular Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, 361021, China. cuixl@hqu.edu.cn.
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Gao
authors.forename: Qiuling
authors.initials: Q
authors.lastname: Song
authors.forename: Guolin
authors.initials: G
authors.lastname: Cheng
authors.forename: Xiuling
authors.initials: X
authors.lastname: Cui
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D011193:Potassium Iodide / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D052160:Benzothiazoles; D014867:Water; D011193:Potassium Iodide