title: Chronic headaches and sleepiness caused by facial soap (containing hydrolyzed wheat proteins)-induced wheat allergy.
abstract: A 38-year-old woman was suffering from irregular headaches and sleepiness. She had used soap containing Glupearl 19S (hydrolyzed wheat proteins) every day for approximately one year and had experienced an episode of rash eruption on her face seven months ago. Wheat-specific IgE antibodies were detected in her serum. A Western blot analysis revealed a high titer of IgE antibodies against Glupearl 19S and wheat proteins. The patient was sensitive to these compounds in a skin prick test. After avoiding eating wheat, her headaches and sleepiness disappeared. A hidden food allergy is a possible cause of these symptoms.
authors.affiliation: Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Japan.
authors.forename: Chifumi
authors.initials: C
authors.lastname: Iseki
authors.forename: Toru
authors.initials: T
authors.lastname: Kawanami
authors.forename: Takahiko
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Chinuki
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
mesh_terms: D000328:Adult; D000982:Antipruritics / Q000627:therapeutic use; D003233:Conjunctivitis, Allergic / Q000188:drug therapy / Q000209:etiology; D006970:Disorders of Excessive Somnolence / Q000209:etiology*; D005260:Female; D020773:Headache Disorders / Q000209:etiology*; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D006868:Hydrolysis; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D010940:Plant Proteins / Q000009:adverse effects* / Q000276:immunology; D012915:Soaps / Q000009:adverse effects*; D021182:Wheat Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000178:diet therapy
chemical_list: D000982:Antipruritics; D006633:Histamine Antagonists; D010940:Plant Proteins; D012915:Soaps; D007073:Immunoglobulin E