title: [The use of topiramate in the treatment of focal epilepsy in children].
abstract: Topiramate was used in the treatment of 66 children, aged 2--16 years (mean age 7.0±4.6 years), including 19 patients with idiopathic form of focal epilepsy (IFE), 21 patients with cryptogenic forms (CFE) and 26 patients with symptomatic forms (SFE). The drug was administered in capsules in dose from 3 to 7 mg/kg/day. Thirty-three patients were on monotherapy, 26 patients received the drug in the combination with one antiepileptic (AED) drug and 7 patients received topiramate in the combination with 2 AEDs. The efficacy of topiramate in focal epilepsy was demonstrated in 65% of patients, including high efficacy in 15% and complete reduction of seizures in 12%. No effect was seen in 27% of patients. The results revealed the high efficacy of topiramate in all subgroups of patients. The significantly higher efficacy was noted in patients with IFE and CFE forms compared to those with SFE form. The tolerability was satisfactory in all subgroups. Side-effects observed in 5 patients were eliminated by increasing the duration of dose titration.
authors.affiliation: Nauchnyĭ tsentr zdorov'ia deteĭ RAMN, Moskva; Institut detskoĭ nevrologii i épilepsii imeni Sviatitelia Luki, Moskva.
authors.forename: M R
authors.initials: MR
authors.lastname: Kremenchugskaia
authors.forename: O V
authors.initials: OV
authors.lastname: Globa
authors.forename: L M
authors.initials: LM
authors.lastname: Kuzenkova
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002214:Capsules; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D000077236:Topiramate; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D002214:Capsules; D004338:Drug Combinations; D000077236:Topiramate; D005632:Fructose