title: Recent advances in thiol and sulfide reactive probes.
abstract: Because of the biological relevance of thiols and sulfides such as cysteine, homocysteine, glutathione and hydrogen sulfide, their detection has attracted a great deal of research interest. Fluorescent probes are emerging as a new strategy for thiol and hydrogen sulfide analysis due to their high sensitivity, low cost, and ability to detect and image thiols in biological samples. In this short review, we have summarized recent advances in the development of thiol and hydrogen sulfide reactive fluorescent probes. These probes are compared and contrasted with regard to their designing strategies, mechanisms, photophysical properties, and/or reaction kinetics. Biological applications of these probes are also discussed.
authors.affiliation: Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, 30303, Georgia, USA.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Hanjing
authors.initials: H
authors.lastname: Peng
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D003545:Cysteine / Q000032:analysis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D005978:Glutathione / Q000032:analysis / Q000737:chemistry; D006710:Homocysteine / Q000032:analysis / Q000737:chemistry; D006862:Hydrogen Sulfide / Q000032:analysis / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000737:chemistry; D013440:Sulfides / Q000032:analysis* / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds; D013440:Sulfides; D006710:Homocysteine; D005978:Glutathione; D003545:Cysteine; D006862:Hydrogen Sulfide
keywords: CYSTEINE; FLUORESCENT PROBES; GLUTATHIONE; HOMOCYSTEINE; HYDROGEN SULFIDE; THIOL DETECTION