title: Reconstructing the infected aortic root with antibiotic impregnated biological glue.
abstract: Prosthetic valve dehiscence and persistent infection are two complications following reconstruction of the aortic root in destructive endocarditis. A technique is described involving the principles of aggressive debridement, closure of large abscess cavities with biological material incorporating a slurry of antibiotic-impregnated biological sealant, and replacement of the aortic valve with an aortic allograft valve. This strategy appears to have been successful in preventing persistent endocarditis and valve dehiscence in a limited number of patients.
authors.affiliation: Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama.
authors.forename: David C
authors.initials: DC
authors.lastname: McGiffin
authors.forename: James E
authors.initials: JE
authors.lastname: Davies
authors.forename: James K
authors.initials: JK
authors.lastname: Kirklin
mesh_terms: D000038:Abscess / Q000601:surgery; D000269:Adhesives / Q000008:administration & dosage / Q000627:therapeutic use*; D064591:Allografts; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001021:Aortic Valve / Q000601:surgery*; D004697:Endocarditis, Bacterial / Q000517:prevention & control; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D019651:Plastic Surgery Procedures / Q000379:methods*; D013529:Surgical Wound Dehiscence / Q000517:prevention & control
chemical_list: D000269:Adhesives; D000900:Anti-Bacterial Agents