title: In this issue: autoimmunity and innate immunity.
abstract: In this issue of the journal, we host a range of topics relevant to innate immunity as well as certain inflammatory diseases. More specifically, Sanz et al. cover a tantalizing form of death called pyroptosis that leads to inflammation. Samasca et al. provide a brief perspective on celiac disease. Singh and collaborators discuss in detail a newly designed leptin antagonist that could be applicable to colitis treatment. Through a meta-analysis, Wen et al. show that IL-18 gene polymorphism is associated with RA and SLE. Adenovirus-triggered innate immunity is discussed by Chen and Lee. Further, Zheng et al. provide a review of lectin receptors and their importance to anti-microbial immunity. Finally, Rojas et al. discuss tantalizing evidence supporting the fact that endogenous danger motifs such as advanced glycation end products are recognized via a TLR-like molecule and signaling pathway.
authors.affiliation: Editor-in-Chief, International Reviews of Immunology, Vice President, Scientific Affairs, Kite Pharma, Inc., Santa Monica, CA, USA.
authors.forename: Adrian
authors.initials: A
authors.lastname: Bot
mesh_terms: D015551:Autoimmunity; D006801:Humans; D007113:Immunity, Innate