title: Cardiovascular risk assessment in prediabetes and undiagnosed diabetes mellitus study: international collaboration research overview.
abstract: The study aims to develop a screening protocol for the risk of future cardiovascular disease and diabetes mellitus in people with prediabetes and undiagnosed diabetes; and to establish a framework for early identification and intervention of prediabetes including strategies for holistic management and monitoring of progression. The first phase is to identify prediabetes and undiagnosed diabetes in volunteers who are ≥18-years-old for 5 years. Point-of-care testing and questionnaire will be used to screen for prediabetes and cardiovascular disease. We anticipate screening more than 2000 individuals of both genders by the end of first phase. The second and third phases which shall run for 5-10 years will be longitudinal study involving participants identified in the first phase as having prediabetes without dyslipidaemia, or clinically established cardiovascular disease. The second phase shall focus on preventive management of risk of progress to diabetes with explicit diagnosis of cardiovascular disease. Oxidative stress measurements will be performed cum evaluation of the use of antioxidants, exercise, and nutrition. The third phase will include probing the development of diabetes and cardiovascular disease. Binomial logistic regression would be performed to generate and propose a model chart for the assessment of cardiovascular disease risk in prediabetes.
authors.affiliation: EHSE, Charles Darwin University, Darwin NT, Australia.
authors.forename: Ezekiel Uba
authors.initials: EU
authors.lastname: Nwose
authors.affiliation: School of Community Health, Charles Sturt University, Albury NSW, Australia.
authors.forename: Ross Stuart
authors.initials: RS
authors.lastname: Richards
authors.affiliation: Public Health Department, Novena University, Ogume, Delta State, Nigeria.
authors.forename: Kester
authors.initials: K
authors.lastname: Digban
authors.affiliation: School of Biomedical Sciences, Charles Sturt University, Wagga, Wagga NSW, Australia.
authors.forename: Philip Taderera
authors.initials: PT
authors.lastname: Bwititi
authors.affiliation: EHSE, Charles Darwin University, Darwin NT, Australia.
authors.forename: Gretchen
authors.initials: G
authors.lastname: Ennis
authors.affiliation: EHSE, Charles Darwin University, Darwin NT, Australia.
authors.forename: Kwang Choon
authors.initials: KC
authors.lastname: Yee
authors.affiliation: Honia Medical Diagnostic and Research Laboratory, Owerri, Nigeria.
authors.forename: Victor Maduabuchi
authors.initials: VM
authors.lastname: Oguoma
authors.affiliation: Menzies School of Health Research, Charles Darwin University, Darwin NT, Australia.
authors.forename: Selma
authors.initials: S
authors.lastname: Liberato
keywords: Early diagnosis; Early intervention; Holistic health management; Public health screening