title: Predictors of health-related quality of life in 500 severely obese patients.
abstract: OBJECTIVE
  To characterize health-related quality of life (HRQL) impairment in severely obese subjects, using several validated instruments.
  
  
  METHODS
  A cross-sectional analysis of 500 severely obese subjects was completed. Short-Form (SF)-12 [Physical (PCS) and Mental (MCS) component summary scores], EuroQol (EQ)-5D [Index and Visual Analog Scale (VAS)], and Impact of Weight on Quality of Life (IWQOL)-Lite were administered. Multivariable linear regression models were performed to identify independent predictors of HRQL.
  
  
  RESULTS
  Increasing BMI was associated with lower PCS (-1.33 points per 5 kg/m(2) heavier; P < 0.001), EQ-index (-0.02; P < 0.001), EQ-VAS (-1.71; P = 0.003), and IWQOL-Lite (-3.72; P = 0.002), but not MCS (P = 0.69). The strongest predictors (all P < 0.005) for impairment in each instrument were: fibromyalgia for PCS (-5.84 points), depression for MCS (-7.49 points), stroke for EQ-index (-0.17 points), less than full-time employment for EQ-VAS (-7.06 points), and coronary disease for IWQOL-Lite (-10.86 points). Chronic pain, depression, and sleep apnea were associated with reduced HRQL using all instruments.
  
  
  CONCLUSIONS
  The clinical impact of BMI on physical and general HRQL was small, and mental health scores were not associated with BMI. Chronic pain, depression, and sleep apnea were consistently associated with lower HRQL.
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, Alberta, Canada; Alberta Diabetes Institute, Edmonton, Alberta, Canada.
authors.forename: Lindsey M
authors.initials: LM
authors.lastname: Warkentin
authors.forename: Sumit R
authors.initials: SR
authors.lastname: Majumdar
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Johnson
authors.forename: Calypse B
authors.initials: CB
authors.lastname: Agborsangaya
authors.forename: Christian F
authors.initials: CF
authors.lastname: Rueda-Clausen
authors.forename: Arya M
authors.initials: AM
authors.lastname: Sharma
authors.forename: Scott W
authors.initials: SW
authors.lastname: Klarenbach
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Birch
authors.forename: Shahzeer
authors.initials: S
authors.lastname: Karmali
authors.forename: Linda
authors.initials: L
authors.lastname: McCargar
authors.forename: Konrad
authors.initials: K
authors.lastname: Fassbender
authors.forename: Raj S
authors.initials: RS
authors.lastname: Padwal
mesh_terms: D000328:Adult; D015992:Body Mass Index; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000453:epidemiology* / Q000523:psychology; D011446:Prospective Studies; D011788:Quality of Life; D012959:Socioeconomic Factors