title: The role of HTS in drug discovery at the University of Michigan.
abstract: High throughput screening (HTS) is an integral part of a highly collaborative approach to drug discovery at the University of Michigan. The HTS lab is one of four core centers that provide services to identify, produce, screen and follow-up on biomedical targets for faculty. Key features of this system are: protein cloning and purification, protein crystallography, small molecule and siRNA HTS, medicinal chemistry and pharmacokinetics. Therapeutic areas that have been targeted include anti-bacterial, metabolic, neurodegenerative, cardiovascular, anti-cancer and anti-viral. The centers work in a coordinated, interactive environment to affordably provide academic investigators with the technology, informatics and expertise necessary for successful drug discovery. This review provides an overview of these centers at the University of Michigan, along with case examples of successful collaborations with faculty.
authors.forename: Martha J
authors.initials: MJ
authors.lastname: Larsen
authors.forename: Scott D
authors.initials: SD
authors.lastname: Larsen
authors.forename: Andrew
authors.initials: A
authors.lastname: Fribley
authors.forename: Jolanta
authors.initials: J
authors.lastname: Grembecka
authors.forename: Kristoff
authors.initials: K
authors.lastname: Homan
authors.forename: Anna
authors.initials: A
authors.lastname: Mapp
authors.forename: Andrew
authors.initials: A
authors.lastname: Haak
authors.forename: Zaneta
authors.initials: Z
authors.lastname: Nikolovska-Coleska
authors.forename: Jeanne A
authors.initials: JA
authors.lastname: Stuckey
authors.forename: Duxin
authors.initials: D
authors.lastname: Sun
authors.affiliation: Center for Chemical Genomics, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA. mjlarsen@umich.edu.
authors.forename: David H
authors.initials: DH
authors.lastname: Sherman
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D055808:Drug Discovery / Q000379:methods* / Q000458:organization & administration; D023281:Genomics / Q000379:methods; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D008824:Michigan; D008967:Molecular Biology / Q000379:methods / Q000458:organization & administration; D010599:Pharmacokinetics; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000302:isolation & purification; D054852:Small Molecule Libraries / Q000494:pharmacology; D014495:Universities / Q000458:organization & administration*
chemical_list: D001688:Biological Products; D011506:Proteins; D054852:Small Molecule Libraries