title: Trichodermone, a spiro-cytochalasan with a tetracyclic nucleus (7/5/6/5) skeleton from the plant endophytic fungus Trichoderma gamsii.
abstract: Trichodermone (1), the first spiro-cytochalasan with an unprecedented tetracyclic nucleus (7/5/6/5), together with its possible biosynthetic precursor aspochalasin D (2), was isolated from the endophytic fungus Trichoderma gamsii. Compound 2 displayed moderate inhibitory activity against HeLa cells with an IC50 value of 5.72 μM.
authors.affiliation: Institute of Medicinal Plant Development , Beijing, People's Republic of China.
authors.forename: Gang
authors.initials: G
authors.lastname: Ding
authors.forename: Hailou
authors.initials: H
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Hongwu
authors.initials: H
authors.lastname: Zhang
authors.forename: Xinzhong
authors.initials: X
authors.lastname: Liu
authors.forename: Zhongmei
authors.initials: Z
authors.lastname: Zou
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D053723:Panax notoginseng / Q000382:microbiology; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003572:Cytochalasins; C430983:aspochalasin D; C587465:trichodermone