title: Effect of a glyphosate-based herbicide on gene expressions of the cytokines interleukin-1β and interleukin-10 and of heme oxygenase-1 in European sea bass, Dicentrarchus labrax L.
abstract: Glyphosate-based herbicides are the most frequently used herbicides in the world. We evaluated the effect of Roundup 360 SL on the expression of interleukin-1β (il-1β), interleukin-10 (il-10) and heme-oxygenase-1 (ho-1) in the gills, intestines and spleen of young European sea bass (Dicentrachus labrax L.), aged 8 mo. A group of fish was exposed to 647 mg/L of Roundup for 96 h. This treatment did not alter gene expression levels of il-1β and il-10 cytokine in the intestines, but significantly lowered both levels in the gills (p = 0.02 and p = 0.04 respectively). Expression levels of ho-1 were increased significantly in the three organs of fish from the treated group (the gills p = 0.04, the intestines p = 0.004 and the spleen p < 0.001). These changes may in turn negatively impact the immune system of European sea bass exposed to Roundup.
authors.affiliation: EB2M-PROTEE, EA 3819, Université de Toulon, 83957, La Garde, France, srichard@univ-tln.fr.
authors.forename: Simone
authors.initials: S
authors.lastname: Richard
authors.forename: Nathalie
authors.initials: N
authors.lastname: Prévot-D'Alvise
authors.forename: Robert
authors.initials: R
authors.lastname: Bunet
authors.forename: Rémy
authors.initials: R
authors.lastname: Simide
authors.forename: Sylvain
authors.initials: S
authors.lastname: Couvray
authors.forename: Stéphane
authors.initials: S
authors.lastname: Coupé
authors.forename: Joël Paul
authors.initials: JP
authors.lastname: Grillasca
mesh_terms: D000818:Animals; D001492:Bass / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D015870:Gene Expression; D005998:Glycine / Q000031:analogs & derivatives* / Q000633:toxicity; D051547:Heme Oxygenase-1 / Q000235:genetics* / Q000378:metabolism; D006540:Herbicides / Q000633:toxicity*; D016753:Interleukin-10 / Q000235:genetics* / Q000378:metabolism; D053583:Interleukin-1beta / Q000235:genetics* / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D000097797:Glyphosate
chemical_list: D005998:Glycine; D051547:Heme Oxygenase-1; D006540:Herbicides; D016753:Interleukin-10; D053583:Interleukin-1beta; D014874:Water Pollutants, Chemical; D000097797:Glyphosate