title: Peri-Implant Tissue Findings in Bone Grafted Oral Cancer Patients Compared to non Bone Grafted Patients without Oral Cancer.
abstract: OBJECTIVE
  The aim of this study was to compare microbiological, histological, and mechanical findings from tissues around osseointergrated dental implants in patients who had undergone tumour resection and subsequent bone grafting with non bone grafted patients without a history of oral cancer and to develop an effective tool for the monitoring of the peri-implant tissues. A third aim was to assess and compare the masticatory function of the two patient groups after reconstruction with dental implants.
  
  
  METHODS
  A total of 20 patients were divided into 2 groups. The first group was edentulous and treated with dental implants without the need for bone grafting. The second edentulous group, with a history of oral cancer involving the mandible, received onlay bone grafts with concurrent placement of dental implants. Microbiological, histological, mechanical and biochemical assessment methods, crevicular fluid flow rate, hygiene-index, implant mobility, and the masticatory function were analysed and compared in both patient groups.
  
  
  RESULTS
  THE MICROBIOLOGICAL EXAMINATIONS SHOWED NO EVIDENCE OF THE THREE MOST COMMON PATHOGENIC BACTERIA: Porphyromonas gingivalis, Prevotella intermedius, Actinobacillus actinomycetencomitans. A causal relationship between specific microbes and peri-implant inflammation could not be found. All biopsies in both patient groups revealed early signs of soft tissue peri-implant inflammation.
  
  
  CONCLUSIONS
  The crevicular fluid volume and grade of gingival inflammation around the dental implants were related. Peri-implant tissue findings were similar in the two patient groups despite the history of oral cancer and the need for bone grafting at the time of dental implant placement.
authors.affiliation: Oral and Maxillofacial Unit, University of Tampere Tampere Finland.
authors.forename: Jan
authors.initials: J
authors.lastname: Wolff
authors.affiliation: Division of Molecular Therapy, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo Tokyo Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Agata
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Oulu Oulu Finland. ; Regea-Institute for Regenerative Medicine, University of Tampere Tampere Finland.
authors.forename: George K
authors.initials: GK
authors.lastname: Sándor
authors.affiliation: Regea-Institute for Regenerative Medicine, University of Tampere Tampere Finland.
authors.forename: Suvi
authors.initials: S
authors.lastname: Haimi
keywords: cancer of the jaw; caugment bone graft; continuity of patient care; mastication; osseointegrated dental implantation; patient monitoring.