title: Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis.
abstract: BACKGROUND
  Cathepsin D C224T polymorphism has been reported to associate with AD susceptibility. But the results were inconsistent. This study aimed to assess the relationship between C224T polymorphism and AD risk.
  
  
  METHODS
  The relevant studies were identified by searching PubMed, Embase, Web of Science, Google Scholar and Wan fang electronic databases updated on July 2013. The relationship between Cathepsin D C224T polymorphism and AD risk was evaluated by ORs and 95% CIs.
  
  
  RESULTS
  A total of 25 case-control studies including 5,602 cases and 11,049 controls were included in the meta-analysis. There was no association between C224T polymorphism and AD risk with all the studies were pooled in the meta-analysis (CT vs. CC: OR = 1.125, 95% CI = 0.974-1.299, P = 0.109; CT + TT vs. CC: OR = 1.136, 95% CI = 0.978-1.320, P = 0.094). Furthermore, when stratified by ethnicity, age of onset and APOEϵ4 status, significant association did not found in all subgroups.
  
  
  CONCLUSIONS
  The present meta-analysis suggested that the Cathepsin D C224T polymorphism was not associated with AD susceptibility.
authors.forename: Cuiju
authors.initials: C
authors.lastname: Mo
authors.forename: Qiliu
authors.initials: Q
authors.lastname: Peng
authors.forename: Jingzhe
authors.initials: J
authors.lastname: Sui
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.forename: Li
authors.initials: L
authors.lastname: Xie
authors.forename: Taijie
authors.initials: T
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: He
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. qinxue919@126.com.
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Shan
authors.initials: S
authors.lastname: Li
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D016022:Case-Control Studies; D002402:Cathepsin D / Q000235:genetics*; D056726:Genetic Association Studies / Q000379:methods*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: C533922:CTSD protein, human; D002402:Cathepsin D