title: [Scintigraphic evaluation of impairments in cardiopulmonary hemodynamics and renal functional activity in patients with coronary heart disease and circulatory failure].
abstract: OBJECTIVE
  To evaluate the relationship between impairments in cardiopulmonary hemodynamics and renal functional activity in patients with circulatory failure, by applying radionuclide studies.
  
  
  METHODS
  Sixty-nine patients with coronary heart disease (mean age 53.23 +/- 0.87 years) with the development of NYHA functional classes II-III chronic HF were examined. To calculate cardiopulmonary hemodynamic parameters, all the patients underwent 99mTc pertechnetate radiocardiopulmonography. Their renal functional activity was assessed by dynamic radionuclide renal scintigraphy using 99mTc-DTPA.
  
  
  RESULTS
  The examinees had most abnormal systemic and pulmonary hemodynamic parameters. Renal dysfunction was detected in 74% of the examinees and reflected by decreased glomerular filtration rates in one or both kidneys and/or a longer tracer elimination half-life from the renal parenchyma. Stepwise regression analysis established a strong inverse correlation between impaired pulmonary circulation, on the one hand, and reduced renal filtration, on the other, and a direct correlation of impairments in renal filtration and evacuation with both left and right ventricular contractility.
  
  
  CONCLUSIONS
  Radionuclide studies are the methods of choice for diagnosis of the cardiorenal continuum.
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Lishmanov
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Vesnina
authors.forename: N G
authors.initials: NG
authors.lastname: Krivonogov
mesh_terms: D002319:Cardiovascular System / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D011652:Pulmonary Circulation; D011877:Radionuclide Imaging / Q000379:methods*; D019275:Radiopharmaceuticals; D012079:Renal Circulation; D051437:Renal Insufficiency / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D012720:Severity of Illness Index; D013670:Sodium Pertechnetate Tc 99m; D013223:Statistics as Topic; D016284:Technetium Tc 99m Pentetate
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m; D016284:Technetium Tc 99m Pentetate