title: Hypoadiponectinemia in obesity: association with insulin resistance.
abstract: Obesity is risk factor for insulin resistance, diabetes, and other chronic diseases. Adiponectin, an adipose-specific protein with antiatherogenic and antiinflammatory effects, were found to be associated with obesity, type 2 diabetes, and insulin resistance. Our aim to identify possible relationships between circulating adiponectin and obesity as well as obesity related phenotypes. A total of 642, obese and non-obese individuals were included in this cross-sectional study. Hormone and glucose levels were estimated using standard protocols. The adiponectin levels showed a significant decrease with increasing quartiles of insulin resistance index. Subjects in lowest quartile of adiponectin level had a significantly higher risk than those in the highest quartile, with higher body mass index, waist circumference, blood pressure, percentage body fat, fat mass, fasting insulin, insulin resistance index, total cholesterol (p < 0.001), low density lipoprotein-cholesterol (p = 0.001), very low density lipoprotein-cholesterol (p = 0.002), and Triglyceride (p = 0.002). The present study indicates that adiponectin is significantly associated with obesity, insulin resistance and other obesity related phenotypes.
authors.affiliation: Department of Physiology, King George's Medical University, Lucknow, UP India.
authors.forename: Jai
authors.initials: J
authors.lastname: Prakash
authors.affiliation: Department of Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP India.
authors.forename: Balraj
authors.initials: B
authors.lastname: Mittal
authors.affiliation: Department of Pediatrics, King George's Medical University, Lucknow, UP India.
authors.forename: Shally
authors.initials: S
authors.lastname: Awasthi
authors.affiliation: Department of Medicine, King George's Medical University, Lucknow, UP India.
authors.forename: C G
authors.initials: CG
authors.lastname: Agarwal
authors.affiliation: Department of Physiology, King George's Medical University, Lucknow, UP India.
authors.forename: Neena
authors.initials: N
authors.lastname: Srivastava
keywords: Adiponectin; Body mass index; Insulin resistance; Obesity; Phenotypes