title: Mutation of the Arabidopsis LON2 peroxisomal protease enhances pexophagy.
abstract: Peroxisomes are critical organelles housing various, often oxidative, reactions. Pexophagy, the process by which peroxisomes are selectively targeted for destruction via autophagy, is characterized in yeast and mammals but had not been reported in plants. In this article, we describe how the peroxisome-related aberrations of a mutant defective in the LON2 peroxisomal protease are suppressed when autophagy is prevented by mutating any of several key autophagy-related (ATG) genes. Our results reveal that plant peroxisomes can be degraded by selective autophagy and suggest that pexophagy is accelerated when the LON2 protease is disabled.
authors.affiliation: Department of Biochemistry and Cell Biology; Rice University; Houston, TX USA.
authors.forename: Bonnie
authors.initials: B
authors.lastname: Bartel
authors.affiliation: Department of Biochemistry and Cell Biology; Rice University; Houston, TX USA.
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Farmer
authors.affiliation: Department of Biochemistry and Cell Biology; Rice University; Houston, TX USA.
authors.forename: Mauro A
authors.initials: MA
authors.lastname: Rinaldi
authors.affiliation: Department of Biochemistry and Cell Biology; Rice University; Houston, TX USA.
authors.forename: Pierce G
authors.initials: PG
authors.lastname: Young
authors.affiliation: Department of Biochemistry and Cell Biology; Rice University; Houston, TX USA.
authors.forename: Charles H
authors.initials: CH
authors.lastname: Danan
authors.affiliation: Department of Biochemistry and Cell Biology; Rice University; Houston, TX USA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Burkhart
mesh_terms: D049069:ATP-Dependent Proteases / Q000235:genetics*; D017360:Arabidopsis / Q000235:genetics*; D029681:Arabidopsis Proteins / Q000235:genetics*; D001343:Autophagy / Q000235:genetics / Q000502:physiology*; D009154:Mutation / Q000235:genetics*; D020675:Peroxisomes / Q000235:genetics*
chemical_list: D029681:Arabidopsis Proteins; D049069:ATP-Dependent Proteases; C000595960:LON2 protein, Arabidopsis
keywords: Arabidopsis thaliana; autophagy; peroxisomal protease; peroxisome remodeling; pexophagy