title: [Advances in microbial production of 5-aminolevulinic acid].
abstract: 5-Aminolevulinic acid is the key intermediate of the tetrapyrrole biosynthesis pathway in organisms and has broad application potentials. This review summarized and discussed recent progress in microbial production of 5-aminolevulinic acid, including screening, isolation and mutation of microbes to produce 5-aminolevulinic acid; microbial whole-cell transformation to synthesize 5-aminolevulinic acid depending on the C4 pathway; construction of high-yield 5-aminolevulinic acid producing strains by metabolic engineering. Finally, future research directions in microbial production of 5-aminolevulinic acid were addressed.
authors.affiliation: Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Kang
authors.affiliation: Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China.
authors.forename: Junli
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, Wuxi 214122, Jiangsu, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.affiliation: School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China.
authors.forename: Guocheng
authors.initials: G
authors.lastname: Du
authors.affiliation: School of Biotechnology, Jiangnan University, Wuxi 214122, Jiangsu, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D000622:Aminolevulinic Acid / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D060847:Metabolic Engineering; D009154:Mutation; D012242:Rhodobacter sphaeroides / Q000235:genetics / Q000378:metabolism
chemical_list: D000622:Aminolevulinic Acid