title: Enantioselective organocatalytic oxa-Michael addition of oximes to β-CF3-β-disubstituted nitroalkenes: efficient synthesis of β-amino-α-trifluoromethyl alcohols.
abstract: An enantioselective oxa-Michael addition of oximes to β-CF3-β-disubstituted nitroalkenes catalyzed by a chiral bifunctional cinchona alkaloid-based thiourea has been developed. A variety of trifluoromethylated oxime ethers possessing a tetrasubstituted carbon stereocenter were obtained in good yields with high enantioselectivities.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan Hubei 430079, China.
authors.forename: Feng-Lei
authors.initials: FL
authors.lastname: Liu
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Feng
authors.forename: Xiao-Qiang
authors.initials: XQ
authors.lastname: Hu
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Ye
authors.forename: Liang-Qiu
authors.initials: LQ
authors.lastname: Lu
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000605:Amino Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D010091:Oximes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000605:Amino Alcohols; D009574:Nitro Compounds; D010091:Oximes