title: Synthesis of a novel supermagnetic iron oxide nanocomposite hydrogel based on graft copolymerization of poly((2-dimethylamino)ethyl methacrylate) onto salep for controlled release of drug.
abstract: In this research, a novel supermagnetic iron oxide nanocomposite hydrogel was prepared using simultaneous in situ formation of iron oxide nanoparticles (IONs) and three-dimensional cross-linked polymer networks based on graft copolymerization of poly((2-dimethylamino)ethyl methacrylate) (PDMA) onto salep (PDMA-g-salep). The prepared ION-PDMA-g-salep hydrogel was systematically characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy with energy dispersive X-ray analysis (SEM-EDAX), transmission electron microscopy (TEM), thermal gravimetric analysis (TGA), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). In addition, the ION-PDMA-g-salep hydrogel exhibits favorable swelling properties that are sensitive to temperature, pH, and external magnetic field (EMF). The drug release behavior of the prepared hydrogel under EMF, different temperatures and pHs was also studied for the evaluation of the release mechanism and determination of diffusion coefficients. Finally, the antibacterial activity and cytotoxicity studies of the prepared hydrogel were examined. These results suggested that the ION-PDMA-g-salep hydrogel could be a promising candidate for biological dressing applications.
authors.affiliation: Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran. Electronic address: rezanejad@pnu.ac.ir.
authors.forename: Ghasem Rezanejade
authors.initials: GR
authors.lastname: Bardajee
authors.affiliation: Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran.
authors.forename: Zari
authors.initials: Z
authors.lastname: Hooshyar
authors.affiliation: Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran.
authors.forename: Maryam Jahanbakhsh
authors.initials: MJ
authors.lastname: Asli
authors.affiliation: Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran.
authors.forename: Fatemeh Emamjome
authors.initials: FE
authors.lastname: Shahidi
authors.affiliation: Department of Chemistry, Payame Noor University, PO BOX 19395-3697, Tehran, Iran.
authors.forename: Nastaran
authors.initials: N
authors.lastname: Dianatnejad
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D002460:Cell Line; D000077588:Deferasirox; D003692:Delayed-Action Preparations / Q000494:pharmacology*; D003911:Dextrans / Q000138:chemical synthesis* / Q000737:chemistry; D004847:Epithelial Cells / Q000166:cytology / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007700:Kinetics; D058185:Magnetite Nanoparticles / Q000737:chemistry; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization / Q000187:drug effects; D011134:Polysaccharides / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects; D013696:Temperature; D013818:Thermogravimetry; D014230:Triazoles / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D001565:Benzoates; D003692:Delayed-Action Preparations; D003911:Dextrans; D058185:Magnetite Nanoparticles; D008689:Methacrylates; D009757:Nylons; D011134:Polysaccharides; D014230:Triazoles; C407037:poly(2-(dimethylamino)ethyl methacrylate); D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C065507:ferumoxides; D000077588:Deferasirox
keywords: Drug release; Hydrogel; Iron oxide nanoparticle; Salep