title: The current state of stem cell therapy for peripheral artery disease.
abstract: Patients with advanced peripheral arterial disease may develop critical limb ischemia with rest pain, non-healing ulcerations, and eventually may require major amputation despite currently available revascularization technologies. Stem cell therapies hold promise as novel therapeutics to promote vasculogenesis and improve tissue perfusion in these patients. This article reviews the current state of stem cell therapy for patients with peripheral arterial disease, with a focus on the cell types that have been studied, barriers to clinical development, and development of new endpoints for clinical trials.
authors.affiliation: Division of Cardiovascular Medicine, Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, 11000 Euclid Ave., LKS 5038, Cleveland, OH, 44106, USA, nitin.gupta@uhhospitals.org.
authors.forename: Nitin K
authors.initials: NK
authors.lastname: Gupta
authors.forename: Ehrin J
authors.initials: EJ
authors.lastname: Armstrong
authors.forename: Sahil A
authors.initials: SA
authors.lastname: Parikh
mesh_terms: D016026:Bone Marrow Transplantation / Q000379:methods; D064987:Cell- and Tissue-Based Therapy / Q000379:methods; D006801:Humans; D007511:Ischemia / Q000209:etiology / Q000517:prevention & control; D007866:Leg / Q000098:blood supply; D023821:Limb Salvage / Q000379:methods; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D018919:Neovascularization, Physiologic; D058729:Peripheral Arterial Disease / Q000150:complications / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation / Q000379:methods; D033581:Stem Cell Transplantation / Q000379:methods*