title: Serum concentrations of organochlorine pesticides p,p'-DDE in adult Thai residents with background levels of exposure.
abstract: In Thailand, DDT was banned for agriculture use in 1983 and for malaria vector control in 1999. However, contamination by DDT and its primary metabolite, p,p'-DDE remains serious environmental and human health concerns. The main focus of this study were i) to investigate serum concentrations of p,p'-DDE and p,p'-DDT as exposure biomarkers for potential adverse health effect in adult Thai residents and ii) to compare the associations of BMI, thyroid hormones, cholesterol, triglycerides and fasting blood sugar levels in human serum with the concentrations of these pesticides. In a total of 1,137 participants were measured blood serum for analyses of p,p'-DDE and p,p'-DDT. The geometric mean concentration (95% confidence interval) for serum total p,p'-DDE concentration was 1,539 (1,242-1,837) ng/g lipid and 1,547 (1,293-1,806) ng/g lipid in adult males and females, respectively. Furthermore, the total amount of serum p,p'-DDE concentration significantly correlated with plasma glucose levels. Neither p,p'-DDE nor p,p'-DDT was significantly associated with serum thyroid hormones levels. Additionally, the high p,p'-DDE/DDT ratio indicates that the exposure is due past rather than recent use of DDT.
authors.affiliation: Division of Toxicology, Department of Medical Sciences, Ministry of Public Health, Thailand.
authors.forename: Punthip
authors.initials: P
authors.lastname: Teeyapant
authors.forename: Sathaporn
authors.initials: S
authors.lastname: Ramchiun
authors.forename: Dutsadee
authors.initials: D
authors.lastname: Polputpisatkul
authors.forename: Chutimon
authors.initials: C
authors.lastname: Uttawichai
authors.forename: Sittiporn
authors.initials: S
authors.lastname: Parnmen
mesh_terms: D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003634:DDT / Q000633:toxicity*; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood*; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000633:toxicity*; D013785:Thailand / Q000453:epidemiology; D013963:Thyroid Hormones / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D013963:Thyroid Hormones; D014280:Triglycerides; D003633:Dichlorodiphenyl Dichloroethylene; D002784:Cholesterol; D003634:DDT