title: [Expression and clinical significance of tumor necrosis factor-alpha and its receptors in non-specific chronic encephalitis and non-encephalitis relative intractable epilepsy].
abstract: OBJECTIVE
  To explore the expression and clinical significance of tumor necrosis factor-alpha (TNF-α) and its receptors p55 and p75 in non-specific chronic encephalitis relative intractable epilepsy (NCERE) and non-NCERE.
  
  
  METHODS
  Immunohistochemical SABC staining was employed to detect the foci of 24 cases of intractable epilepsy (NCERE, n = 10; non-NCERE, n = 14) and 10 cases of the expression of TNF-α and its receptors p55 and p75 in normal brain tissues (control group) to analyze their clinical significance.
  
  
  RESULTS
  All expressions of the control group were negative. TNF-α and its receptors p55 and p75 were differentially expressed in neuron cytoplasm between NCERE and non-NCERE. No statistical significance existed between NCERE and non-NCERE (P > 0.05). There was a positive correlation between the expressions of receptors p55 and p75 (r = 0.897, P < 0.05).
  
  
  CONCLUSIONS
  By binding its receptors and the synergistic effect between receptors p55 and p75, TNF-αis involved in the generation and development of NCERE and non-NCERE. However it appears to have nothing to do with the etiology of epilepsy.
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, Fujian Medical University, Fujian 350005, China. Email: lyx99070@163.com.
authors.forename: Yuan-xiang
authors.initials: YX
authors.lastname: Lin
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, Fujian Medical University, Fujian 350005, China.
authors.forename: Zhong-xing
authors.initials: ZX
authors.lastname: Ye
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, Fujian Medical University, Fujian 350005, China.
authors.forename: De-zhi
authors.initials: DZ
authors.lastname: Kang
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, Fujian Medical University, Fujian 350005, China.
authors.forename: Kun
authors.initials: K
authors.lastname: Lin
authors.affiliation: Department of Neurosurgery, First Affiliated Hospital, Fujian Medical University, Fujian 350005, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Wang
mesh_terms: D002908:Chronic Disease; D004660:Encephalitis / Q000378:metabolism* / Q000473:pathology; D004827:Epilepsy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha