title: Fabrication of bifunctional gold/gelatin hybrid nanocomposites and their application.
abstract: Herein, a facile method is presented to integrate large gold nanoflowers (∼80 nm) and small gold nanoparticles (2-4 nm) into a single entity, exhibiting both surface-enhanced Raman scattering (SERS) and catalytic activity. The as-prepared gold nanoflowers were coated by a gelatin layer, in which the gold precursor was adsorbed and in situ reduced into small gold nanoparticles. The thickness of the gelatin shell is controlled to less than 10 nm, ensuring that the small gold nanoparticles are still in a SERS-active range of the inner Au core. Therefore, the reaction catalyzed by these nanocomposites can be monitored in situ using label-free SERS spectroscopy. In addition, these bifunctional nanocomposites are also attractive candidates for application in SERS monitoring of bioreactions because of their excellent biocompatibility.
authors.affiliation: School of Materials Science and Engineering, University of Science and Technology Beijing , Beijing 100083, China.
authors.forename: Qianling
authors.initials: Q
authors.lastname: Cui
authors.forename: Alexey
authors.initials: A
authors.lastname: Yashchenok
authors.forename: Lu
authors.initials: L
authors.lastname: Zhang
authors.forename: Lidong
authors.initials: L
authors.lastname: Li
authors.forename: Admir
authors.initials: A
authors.lastname: Masic
authors.forename: Gabriele
authors.initials: G
authors.lastname: Wienskol
authors.forename: Helmuth
authors.initials: H
authors.lastname: Möhwald
authors.forename: Matias
authors.initials: M
authors.lastname: Bargheer
mesh_terms: D000818:Animals; D005399:Fishes; D005780:Gelatin / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013059:Spectrum Analysis, Raman; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D013438:Sulfhydryl Compounds; C014712:4-nitrothiophenolate; D006046:Gold; D005780:Gelatin