title: Assessment of linezolid efficacy, safety and tolerability in the treatment of tuberculosis: A retrospective case review.
abstract: Linezolid is a potentially effective drug for the treatment of patients with drug-resistant tuberculosis. Among 13 patients treated for tuberculosis with linezolid in the present study, nine had treatment success and four remain on treatment. Adverse effects occurred in 11 (85%) patients, of whom three discontinued treatment because of adverse effects. The present study adds to the growing evidence supporting the efficacy of linezolid for tuberculosis, although treatment remains complicated by adverse effects.
authors.affiliation: Department of Pediatrics, University of Alberta, Edmonton, Alberta.
authors.forename: Alena
authors.initials: A
authors.lastname: Tse-Chang
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, Alberta.
authors.forename: Dennis
authors.initials: D
authors.lastname: Kunimoto
authors.affiliation: Central TB Services, Alberta Health Services, Edmonton, Alberta.
authors.forename: Evelina
authors.initials: E
authors.lastname: Der
authors.affiliation: Department of Medicine, University of Alberta, Edmonton, Alberta.
authors.forename: Rabia
authors.initials: R
authors.lastname: Ahmed
keywords: Drug-resistant TB; Linezolid; Toxicity; Treatment outcomes