title: PANOGA: a web server for identification of SNP-targeted pathways from genome-wide association study data.
abstract: Genome-wide association studies (GWAS) have revolutionized the search for the variants underlying human complex diseases. However, in a typical GWAS, only a minority of the single-nucleotide polymorphisms (SNPs) with the strongest evidence of association is explained. One possible reason of complex diseases is the alterations in the activity of several biological pathways. Here we present a web server called Pathway and Network-Oriented GWAS Analysis to devise functionally important pathways through the identification of SNP-targeted genes within these pathways. The strength of our methodology stems from its multidimensional perspective, where we combine evidence from the following five resources: (i) genetic association information obtained through GWAS, (ii) SNP functional information, (iii) protein-protein interaction network, (iv) linkage disequilibrium and (v) biochemical pathways.
authors.affiliation: Department of Genetics and Bioinformatics, Faculty of Arts and Sciences, Bahcesehir University, 34353, Besiktas, Istanbul, Turkey, Department of Computer Engineering, Faculty of Engineering and Natural Sciences, Abdullah Gul University, 38039, Kayseri, Turkey, Department of Computer Engineering, Faculty of Engineering and Natural Sciences, Sabanci University, 34956, Tuzla, Istanbul, Turkey and Department of Biological Sciences and Bioengineering, Faculty of Engineering and Natural Sciences, Sabanci University, 34956, Tuzla, Istanbul, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Bakir-Gungor
authors.forename: Ece
authors.initials: E
authors.lastname: Egemen
authors.forename: Osman Ugur
authors.initials: OU
authors.lastname: Sezerman
mesh_terms: D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D020407:Internet; D015810:Linkage Disequilibrium; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D011506:Proteins