title: Rescue of kidney function in a toddler with anti-GBM nephritis.
abstract: Anti-glomerular basement membrane (anti-GBM) nephritis is rare in childhood with few published cases. We report a 19-month-old boy with rapidly progressive glomerulonephritis (RPGN) due to anti-GBM nephritis. Treatment was started under 2 weeks after presentation and included plasma exchange, intravenous high-dose methylprednisolone, intravenous cyclophosphamide and mycophenolate as mainstay medication. The treatment was rapidly effective with immediate decrease in anti-GBM titres and plasma creatinine. Three years after presentation, the boy has normal kidney function, blood pressure and no residual disease. The successful outcome was likely due to the rapid recognition of the anti-GBM antibodies as the cause of RPGN and aggressive primary treatment.
authors.affiliation: Department of Pediatrics, Division for Specialised Medicine , Oslo University Hospital , Rikshospitalet, Oslo , Norway.
authors.forename: Anna
authors.initials: A
authors.lastname: Bjerre
authors.affiliation: Department of Immunology and Transfusion Medicine , Sykehuset Innlandet Trust , Lillehammer , Norway.
authors.forename: Kolbjørn
authors.initials: K
authors.lastname: Høgåsen
authors.affiliation: Department of Pediatrics , Sykehuset Innlandet Trust , Elverum , Norway.
authors.forename: Jon
authors.initials: J
authors.lastname: Grøtta
authors.affiliation: Department of Pathology, Division for Diagnostics and Intervention , Oslo University Hospital , Rikshospitalet, Oslo , Norway.
authors.forename: Helge
authors.initials: H
authors.lastname: Scott
authors.affiliation: Department of Pediatrics, Division for Specialised Medicine , Oslo University Hospital , Rikshospitalet, Oslo , Norway.
authors.forename: Trine
authors.initials: T
authors.lastname: Tangeraas
authors.affiliation: Department of Transplant Medicine , Oslo University Hospital , Rikshospitalet, Oslo , Norway.
authors.forename: Christina
authors.initials: C
authors.lastname: Dörje
keywords: RPGN; anti-GBM nephritis; kidney function; toddler