title: [Analgesic properties of morpholinoethylimidazobenzimidazole derivative RU-1205].
abstract: We have studied the analgesic activity of a morpholinoethylimidazobenzimidazole derivative (RU-1205) in comparison to butorphanol. It is established that the test compound exhibits a pronounced analgesic activity, which exceeded that ofbutorphanol six times in the hot-plate test and was comparable to the reference drug effect in the tail-flick and acetic acid-induced writhing tests. It is established that the analgesic action of RU-1205 is based on the kappa-opioidergic mechanism.
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Grechko
authors.forename: D M
authors.initials: DM
authors.lastname: Shtareva
authors.forename: V A
authors.initials: VA
authors.lastname: Anisimova
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D001562:Benzimidazoles / Q000494:pharmacology*; D002077:Butorphanol / Q000494:pharmacology; D008297:Male; D051379:Mice; D009025:Morpholines / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D059225:Nociception / Q000187:drug effects*; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D051381:Rats; D017473:Receptors, Opioid, kappa / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: C586860:9-(2-morpholinoethyl)-2-(4-fluorophenyl)imidazo(1,2-alpha)benzimidazole; D000700:Analgesics; D001562:Benzimidazoles; D009025:Morpholines; D009292:Narcotic Antagonists; D017473:Receptors, Opioid, kappa; D009270:Naloxone; C051844:norbinaltorphimine; D009271:Naltrexone; D002077:Butorphanol