title: GSTO1 uncommon genetic variants are associated with recurrent miscarriage risk.
abstract: OBJECTIVE
  To explore the role of the GSTO1 gene in the pathogenesis of recurrent miscarriage (RM).
  
  
  METHODS
  Genetic association study.
  
  
  METHODS
  Rome, Italy.
  
  
  METHODS
  123 women with RM and 130 women without pregnancy complications.
  
  
  METHODS
  None.
  
  
  METHODS
  Genotyping of two single nucleotide polymorphisms (A140D and E208K) and a 3-bp deletion (E155del) of the GSTO1 gene.
  
  
  RESULTS
  We found a statistically significant association between GSTO1*E208K variants and RM risk. Specifically, we identified this uncommon genetic variant only in women with RM. None of the women with physiologic pregnancies were carriers of K208 allele.
  
  
  CONCLUSIONS
  GSTO1 has a role in detoxification metabolism, and we hypothesize that a functional variation of GSTO1 is a RM risk factor that interacts with environmental conditions.
authors.affiliation: Department of Biology, University of Rome "Tor Vergata," Rome, Italy.
authors.forename: Renato
authors.initials: R
authors.lastname: Polimanti
authors.affiliation: Department of Biology, University of Rome "Tor Vergata," Rome, Italy.
authors.forename: Maria Eleonora
authors.initials: ME
authors.lastname: Graziano
authors.affiliation: Clinical Pathophysiology Center, Associazione Fatebenefratelli per la Ricerca "San Giovanni Calibita," Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy.
authors.forename: Natalia
authors.initials: N
authors.lastname: Lazzarin
authors.affiliation: Department of Obstetrics and Gynaecology, University of Rome "Tor Vergata," Rome, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Vaquero
authors.affiliation: Clinical Pathophysiology Center, Associazione Fatebenefratelli per la Ricerca "San Giovanni Calibita," Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy.
authors.forename: Dario
authors.initials: D
authors.lastname: Manfellotto
authors.affiliation: Department of Biology, University of Rome "Tor Vergata," Rome, Italy. Electronic address: fuciarelli@uniroma2.it.
authors.forename: Maria
authors.initials: M
authors.lastname: Fuciarelli
mesh_terms: D000026:Abortion, Habitual / Q000175:diagnosis* / Q000235:genetics*; D000328:Adult; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D014644:Genetic Variation / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: C490476:GSTO1 protein, human; D005982:Glutathione Transferase
keywords: Arsenic; GSTO1; ascorbate; genetic predisposition; phase II enzymes; pregnancy loss