title: Synthesis and characterization of glycoconjugated porphyrin triphenylamine hybrids for targeted two-photon photodynamic therapy.
abstract: In order to avoid side effects at the time of cancer eradication to the patients, the selectivity of treatments has become of strategic importance. In the case of photodynamic therapy (PDT), two-photon absorption combined with active targeting of tumors could allow both spatial and chemical selectivity. In this context, we present the synthesis, spectroscopic, and biological properties of a series of porphyrin-triphenylamine hybrids with excellent singlet oxygen production capacities and good two-photon absorption.
authors.affiliation: Institut Curie, Section de Recherches, Bât 110-112, Centre Universitaire , F-91405 Orsay, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Hammerer
authors.forename: Guillaume
authors.initials: G
authors.lastname: Garcia
authors.forename: Su
authors.initials: S
authors.lastname: Chen
authors.forename: Florent
authors.initials: F
authors.lastname: Poyer
authors.forename: Sylvain
authors.initials: S
authors.lastname: Achelle
authors.forename: Céline
authors.initials: C
authors.lastname: Fiorini-Debuisschert
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Teulade-Fichou
authors.forename: Philippe
authors.initials: P
authors.lastname: Maillard
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D005075:Biological Evolution; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000188:drug therapy*; D019281:Dimerization; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D010778:Photochemotherapy; D017785:Photons / Q000627:therapeutic use; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use*; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000814:Aniline Compounds; D006001:Glycoconjugates; D017319:Photosensitizing Agents; D011166:Porphyrins; D026082:Singlet Oxygen