title: Method for the discrimination of superficial and deep absorption variations by time domain fNIRS.
abstract: A method for the discrimination of superficial and deep absorption variations by time domain functional near infrared spectroscopy is presented. The method exploits the estimate of the photon time-dependent pathlength in different domains of the sampled medium and makes use of an approach based on time-gating of the photon distribution of time-of-flights. Validation of the method is performed in the two-layer geometry to focus on muscle and head applications. Numerical simulations varied the thickness of the upper layer, the interfiber distance, the shape of the instrument response function and the photon counts. Preliminary results from in vivo data are also shown.
authors.affiliation: Dipartimento di Fisica, Politecnico di Milano, Milan, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Zucchelli
authors.affiliation: Dipartimento di Fisica, Politecnico di Milano, Milan, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Contini
authors.affiliation: Dipartimento di Fisica, Politecnico di Milano, Milan, Italy.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Re
authors.affiliation: Dipartimento di Fisica, Politecnico di Milano, Milan, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Torricelli
authors.affiliation: Istituto di Fotonica e Nanotecnologie (IFN) - CNR, Milan, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Spinelli
keywords: (170.1470) Blood or tissue constituent monitoring; (170.2655) Functional monitoring and imaging; (170.5280) Photon migration; (170.6920) Time-resolved imaging