title: Pericardial, intra-abdominal, and subcutaneous adipose tissue in patients with major depressive disorder.
abstract: OBJECTIVE
  Major depressive disorder (MDD) is associated with an increased risk for developing coronary artery disease (CAD). Recently, pericardial adipose tissue, a metabolically active visceral fat depot surrounding the heart, has been implicated in the pathogenesis of CAD. Therefore, we investigated pericardial adipose tissue volumes in patients with MDD and compared them to healthy comparison subjects.
  
  
  METHODS
  In this case-control study at a university medical center, 50 male and female in-patients with MDD and 25 healthy men and women were examined. The main outcome measures were the volumes of pericardial adipose tissue, intra-abdominal adipose tissue (IaAT) and subcutaneous adipose tissue (ScAT) which were measured using magnetic resonance imaging.
  
  
  RESULTS
  The pericardial adipose tissue volumes were greater in men and women with MDD compared with the healthy comparison group following adjustments for the effects of age, weight, height, and physical activity.
  
  
  CONCLUSIONS
  This study expands our knowledge about the alterations in body composition that occur in patients with MDD. The findings are highly relevant for understanding the comorbidity between heart disease and depressive disorders.
authors.affiliation: Department of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School (MHH), Hannover, Germany.
authors.forename: K G
authors.initials: KG
authors.lastname: Kahl
authors.forename: K
authors.initials: K
authors.lastname: Hueper
authors.forename: U
authors.initials: U
authors.lastname: Schweiger
authors.forename: M
authors.initials: M
authors.lastname: Gutberlet
authors.forename: A-M
authors.initials: AM
authors.lastname: Detlef
authors.forename: C
authors.initials: C
authors.lastname: Weiss
authors.forename: A
authors.initials: A
authors.lastname: von Bohlen
authors.forename: R
authors.initials: R
authors.lastname: Pul
authors.forename: R
authors.initials: R
authors.lastname: Lichtinghagen
authors.forename: F
authors.initials: F
authors.lastname: Wacker
authors.forename: D
authors.initials: D
authors.lastname: Hartung
mesh_terms: D052436:Adipose Tissue, White / Q000473:pathology*; D000328:Adult; D003865:Major Depressive Disorder / Q000150:complications*; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000473:pathology*; D050151:Subcutaneous Fat / Q000473:pathology
keywords: cardio-vascular diseases; depression; diabetes mellitus