title: Effect of Cu content on the antibacterial activity of titanium-copper sintered alloys.
abstract: The phase constitution and the microstructure Ti-x Cu (x=2, 5, 10 and 25 wt.%) sintered alloys were investigated by XRD and SEM and the antibacterial activity was assessed in order to investigate the effect of the Cu content on the antibacterial activity. The results have shown that Ti2Cu was synthesized as a main secondary phase in all Ti-Cu alloys while Cu-rich phase was formed in the alloys with 5 wt.% or more copper. Antibacterial tests have showed that the Cu content influences the antibacterial rate seriously and only the alloys with 5 wt.% or high Cu have a strong and stable antibacterial rate, which indicates that the Cu content in Ti-Cu alloys must be at least 5 wt.% to obtain strong and stable antibacterial property. The Cu content also influenced the Cu ion release behavior. High Cu ion release concentration and high Cu ion release rate were observed for Ti-Cu alloys with high Cu content. It was concluded that the Cu content affects the Cu existence and the Cu ion release behavior, which in turn influences the antibacterial property. It was thought that the Cu-rich phase should play an important role in the strong antibacterial activity.
authors.affiliation: Jiamusi University, Jiamusi 154007, PR China; Dept. Prosthodontics, The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.affiliation: Jiamusi University, Jiamusi 154007, PR China.
authors.forename: Fangbing
authors.initials: F
authors.lastname: Li
authors.affiliation: Jiamusi University, Jiamusi 154007, PR China.
authors.forename: Cong
authors.initials: C
authors.lastname: Liu
authors.affiliation: Jiamusi University, Jiamusi 154007, PR China.
authors.forename: Hongying
authors.initials: H
authors.lastname: Wang
authors.affiliation: Jiamusi University, Jiamusi 154007, PR China.
authors.forename: Baorui
authors.initials: B
authors.lastname: Ren
authors.affiliation: Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, PR China.
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.affiliation: Jiamusi University, Jiamusi 154007, PR China; Key Lab. for Anisotropy and Texture of Materials, Education Ministry of China, Northeastern University, Shenyang 110819, PR China. Electronic address: zhangel@atm.neu.edu.cn.
authors.forename: Erlin
authors.initials: E
authors.lastname: Zhang
mesh_terms: D000497:Alloys / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D019245:Compressive Strength; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology*; D006244:Hardness; D006358:Hot Temperature; D008422:Materials Testing; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D003300:Copper; D014025:Titanium
keywords: Antibacterial activity; Antibacterial alloy; Cu-rich phase; Galvanic corrosion; Ti–Cu alloy