title: Prenatal ultrasonographic diagnosis of generalized arterial calcification of infancy.
abstract: A healthy 19-year-old nulliparous pregnant woman was referred to our clinic because of fetal pericardial effusion and ascites. The sonographic examination performed at 28 weeks' gestation revealed scalp edema, severe skin edema, bilateral hydrocele, ascites, and pleural and pericardial effusion. Fetal echocardiographic examination showed that both ventricles were dilated with severely depressed contractility. The aortic annulus, ascending aorta, aortic arch, descending aorta, common iliac arteries, main pulmonary artery, tricuspid valve, and mitral chordae tendinae were hyperechogenic. Right ventricular outflow tract was narrow with decreased blood flow. There was tricuspid and mitral valve regurgitation and tricuspid valve stenosis. On the basis of these findings, we made the diagnosis of generalized arterial calcification, which is characterized by extensive calcification of internal elastic lamina and intimal proliferation of medium-sized and large arteries. This diagnosis was confirmed histologically after the termination of pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Istanbul University Faculty of Medicine, Capa/Fatih, 34090, Istanbul, Turkey.
authors.forename: Aytul
authors.initials: A
authors.lastname: Corbacioglu Esmer
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Kalelioglu
authors.forename: Rukiye Eker
authors.initials: RE
authors.lastname: Omeroglu
authors.forename: Hulya
authors.initials: H
authors.lastname: Kayserili
authors.forename: Mine
authors.initials: M
authors.lastname: Gulluoglu
authors.forename: Recep
authors.initials: R
authors.lastname: Has
authors.forename: Atıl
authors.initials: A
authors.lastname: Yuksel
mesh_terms: D000025:Abortion, Eugenic; D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D011247:Pregnancy; D016216:Ultrasonography, Prenatal / Q000379:methods*; D061205:Vascular Calcification / Q000000981:diagnostic imaging*; D055815:Young Adult
keywords: arterial calcification; generalized; idiopathic; prenatal diagnosis; ultrasound