title: Analysis of intervention strategies for inhalation exposure to polycyclic aromatic hydrocarbons and associated lung cancer risk based on a Monte Carlo population exposure assessment model.
abstract: It is difficult to evaluate and compare interventions for reducing exposure to air pollutants, including polycyclic aromatic hydrocarbons (PAHs), a widely found air pollutant in both indoor and outdoor air. This study presents the first application of the Monte Carlo population exposure assessment model to quantify the effects of different intervention strategies on inhalation exposure to PAHs and the associated lung cancer risk. The method was applied to the population in Beijing, China, in the year 2006. Several intervention strategies were designed and studied, including atmospheric cleaning, smoking prohibition indoors, use of clean fuel for cooking, enhancing ventilation while cooking and use of indoor cleaners. Their performances were quantified by population attributable fraction (PAF) and potential impact fraction (PIF) of lung cancer risk, and the changes in indoor PAH concentrations and annual inhalation doses were also calculated and compared. The results showed that atmospheric cleaning and use of indoor cleaners were the two most effective interventions. The sensitivity analysis showed that several input parameters had major influence on the modeled PAH inhalation exposure and the rankings of different interventions. The ranking was reasonably robust for the remaining majority of parameters. The method itself can be extended to other pollutants and in different places. It enables the quantitative comparison of different intervention strategies and would benefit intervention design and relevant policy making.
authors.affiliation: Department of Building Science, School of Architecture, Tsinghua University, Beijing, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.affiliation: Department of Building Science, School of Architecture, Tsinghua University, Beijing, PR China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
mesh_terms: D000397:Air Pollution / Q000032:analysis; D001272:Atmosphere / Q000737:chemistry; D002648:Child; D005260:Female; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008954:Models, Biological; D009010:Monte Carlo Method; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity*; D011157:Population Dynamics; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012621:Seasons
chemical_list: D011084:Polycyclic Aromatic Hydrocarbons