title: Influence of different cosmetic formulations on the human skin barrier.
abstract: The human skin barrier is an important part of the skin's intactness and its functionality is a precondition for healthy skin. Ingredients in cosmetic formulations, especially penetration enhancers, can influence this barrier function as they transport active agents into deeper skin layers. In this study different cosmetic formulations were tested by 60 healthy female volunteers over a period of 4 weeks. The skin hydration and barrier function before and during the application were measured. Significant changes in both parameters were determined. A negative influence on the barrier function by penetration enhancers could be observed, but it was also found that lamellar lipid structures (DermaMembranSysteme®, DMS®) are able to enhance the skin barrier. Both penetration enhancers as well as DMS can increase skin hydration.
authors.affiliation: Institute for Experimental Dermatology, DermaTronnier, University of Witten/Herdecke, Witten, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Heinrich
authors.forename: U
authors.initials: U
authors.lastname: Heinrich
authors.forename: H
authors.initials: H
authors.lastname: Tronnier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001692:Biological Transport; D003358:Cosmetics / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006801:Humans; D008055:Lipids / Q000008:administration & dosage* / Q000737:chemistry; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*; D055815:Young Adult
chemical_list: D003358:Cosmetics; D008055:Lipids