title: Polymorphisms in glutathione S-transferase are risk factors for perioperative acute myocardial infarction after cardiac surgery: a preliminary study.
abstract: In the present study we explored glutathione S-transferase (GST) polymorphisms in selected patients who experienced accelerated myocardial injury following open heart surgery and compared these to a control group of patients without postoperative complications. 758 Patients were enrolled from which 132 patients were selected to genotype analysis according to exclusion criteria. Patients were divided into the following groups: Group I: control patients (n = 78) without and Group II.: study patients (n = 54) with evidence of perioperative myocardial infarction. Genotyping for GSTP1 A (Ile105Ile/Ala113Ala), B (Ile105Val/Ala113Ala) and C (Ile105Val/Ala113Val) alleles was performed by using real-time-PCR. The heterozygous AC allele was nearly three times elevated (18.5 vs. 7.7 %) in the patients who suffered postoperative myocardial infarction compared to controls. Contrary, we found allele frequency of 14.1 % for homozygous BB allele in the control group whereas no such allele combination was present in the study group. These preliminary results may suggest the protective role for the B and C alleles during myocardial oxidative stress whereas the A allele may represent predisposing risk for cellular injury in patients undergoing cardiac surgery.
authors.affiliation: Department of Surgical Research and Techniques, Medical Faculty, University of Pécs, 20 Kodály Z Street, Pecs, 7624, Hungary.
authors.forename: Viktória
authors.initials: V
authors.lastname: Kovacs
authors.forename: Balazs
authors.initials: B
authors.lastname: Gasz
authors.forename: Borbala
authors.initials: B
authors.lastname: Balatonyi
authors.forename: Luca
authors.initials: L
authors.lastname: Jaromi
authors.forename: Peter
authors.initials: P
authors.lastname: Kisfali
authors.forename: Balazs
authors.initials: B
authors.lastname: Borsiczky
authors.forename: Gabor
authors.initials: G
authors.lastname: Jancso
authors.forename: Nandor
authors.initials: N
authors.lastname: Marczin
authors.forename: Sandor
authors.initials: S
authors.lastname: Szabados
authors.forename: Bela
authors.initials: B
authors.lastname: Melegh
authors.forename: Alotti
authors.initials: A
authors.lastname: Nasri
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Roth
mesh_terms: D000483:Alleles; D006348:Cardiac Surgical Procedures / Q000379:methods; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics* / Q000601:surgery; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D005982:Glutathione Transferase