title: Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein.
authors.affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: S
authors.initials: S
authors.lastname: Shukla
authors.affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: E E
authors.initials: EE
authors.lastname: Chufan
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY, USA.
authors.forename: S
authors.initials: S
authors.lastname: Singh
authors.affiliation: NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD, USA.
authors.forename: A P
authors.initials: AP
authors.lastname: Skoumbourdis
authors.affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: K
authors.initials: K
authors.lastname: Kapoor
authors.affiliation: NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Boxer
authors.affiliation: NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD, USA.
authors.forename: D Y
authors.initials: DY
authors.lastname: Duveau
authors.affiliation: NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, Rockville, MD, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Thomas
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St John's University, Queens, NY, USA.
authors.forename: T T
authors.initials: TT
authors.lastname: Talele
authors.affiliation: Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: S V
authors.initials: SV
authors.lastname: Ambudkar
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry* / Q000378:metabolism; D001549:Benzamides / Q000378:metabolism; D001665:Binding Sites; D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors*; D006801:Humans; D000068877:Imatinib Mesylate; D010879:Piperazines / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000378:metabolism*; D011743:Pyrimidines / Q000378:metabolism*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl; C498826:nilotinib