title: The assessment of oxidative stress on patients with chronic renal failure at different stages and on dialysis patients receiving different hypertensive treatment.
abstract: The aim of this study is to evaluate the oxidative stress in predialysis, hemodialysis (HD) and peritoneal dialysis patients and to test the effects of antihypertensive drugs and volume control on oxidative stress parameters. The study was composed of five groups as follows: control group (n = 30), predialysis group (n = 30), peritoneal dialysis group (n = 30), hemodialysis group, (normotensive with strict volume control, n = 30), hemodialysis group (normotensive with medication, n = 30). Plasma malondialdehyde (MDA), erythrocyte superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx) and routine biochemical parameters were studied in all patients. Hemodialysis patients with strict volume control (HDvc) had lower levels of MDA than other patient groups (p < 0.001), and CAT, SOD values had highest level other patient groups (p < 0.001). The treatment of hypertension with strict volume control in chronic renal failure patients causes less damage to the antioxidant capacity.
authors.affiliation: Erciyes University Halil Bayraktar SHMYO, 38039 Kayseri, Turkey.
authors.forename: Servin Yeşil
authors.initials: SY
authors.lastname: Günal
authors.affiliation: Biochemistry Department, Fırat University, 23030 Elazığ, Turkey.
authors.forename: Bilal
authors.initials: B
authors.lastname: Ustündağ
authors.affiliation: Nephrology Department, Education and Research Hospital, Kayseri, Turkey.
authors.forename: Ali İhsan
authors.initials: Aİ
authors.lastname: Günal
keywords: Chronic renal failure; Oxidative stress; Volume control