title: Chemical composition and in vitro cytotoxic activity of the essential oils of Stachys rupestris and Salvia heldreichiana, two endemic plants of Turkey.
abstract: The chemical composition of the essential oils of two endemic plants of Turkey, Stachys rupestris Montbret et Aucher ex Benth. and Salvia heldreichiana Boiss. ex Benth., were obtained by hydrodistillation and studied by GC and GC-MS. In all, 46 compounds were identified, 22 for S. rupestris accounting for 94.6% of the total oil and 30 for S. heldreichiana, accounting for 91.9% of the total oil. The presence of diterpenoids (50.7%) characterized the oil from S. rupestris, while S. heldreichiana oil was rich in oxygenated sesquiterpenes (78.9%).The essential oils were evaluated for their in vitro potential cytotoxic activity on three human cancer cell lines. The oil of S. rupestris showed the higher antiproliferative activity against PC-3 and MCF-7 cancer cell lines.
authors.affiliation: Department of Biology, Faculty of Science and Letters, Mersin University, Ciftlikkoy campus, 33342 Mezitli, Mersin, Turkey. eliferdogan81@gmail.com
authors.forename: Elif Ayşe
authors.initials: EA
authors.lastname: Erdogan
authors.affiliation: Department of Biology, Faculty of Science and Letters, Mersin University, Ciftlikkoy campus, 33342 Mezitli, Mersin, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Everest
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, 84084 Fisciano (Salerno), Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: De Martino
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, 84084 Fisciano (Salerno), Italy.
authors.forename: Emilia
authors.initials: E
authors.lastname: Mancini
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, 84084 Fisciano (Salerno), Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Festa
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Via Ponte don Melillo, 84084 Fisciano (Salerno), Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: De Feo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D009822:Oils, Volatile / Q000032:analysis* / Q000494:pharmacology; D027544:Salvia / Q000737:chemistry*; D031366:Stachys / Q000737:chemistry*; D014421:Turkey
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D009822:Oils, Volatile