title: Experimental measurements of energy augmentation for mechanical circulatory assistance in a patient-specific Fontan model.
abstract: A mechanical blood pump specifically designed to increase pressure in the great veins would improve hemodynamic stability in adolescent and adult Fontan patients having dysfunctional cavopulmonary circulation. This study investigates the impact of axial-flow blood pumps on pressure, flow rate, and energy augmentation in the total cavopulmonary circulation (TCPC) using a patient-specific Fontan model. The experiments were conducted for three mechanical support configurations, which included an axial-flow impeller alone in the inferior vena cava (IVC) and an impeller with one of two different protective stent designs. All of the pump configurations led to an increase in pressure generation and flow in the Fontan circuit. The increase in IVC flow was found to augment pulmonary arterial flow, having only a small impact on the pressure and flow in the superior vena cava (SVC). Retrograde flow was neither observed nor measured from the TCPC junction into the SVC. All of the pump configurations enhanced the rate of power gain of the cavopulmonary circulation by adding energy and rotational force to the fluid flow. We measured an enhancement of forward flow into the TCPC junction, reduction in IVC pressure, and only minimally increased pulmonary arterial pressure under conditions of pump support.
authors.affiliation: BioCirc Research Laboratory, Department of Mechanical and Nuclear Engineering, School of Engineering, Virginia Commonwealth University, Richmond, VA, USA.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Chopski
authors.forename: Owen M
authors.initials: OM
authors.lastname: Rangus
authors.forename: William B
authors.initials: WB
authors.lastname: Moskowitz
authors.forename: Amy L
authors.initials: AL
authors.lastname: Throckmorton
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D004867:Equipment Design; D018729:Fontan Procedure / Q000295:instrumentation*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D011651:Pulmonary Artery / Q000601:surgery; D014682:Vena Cava, Inferior / Q000601:surgery; D014683:Vena Cava, Superior / Q000601:surgery; D055815:Young Adult
keywords: Artificial right ventricle; Blood pump; Cavopulmonary assist device; Fontan conversion; Mechanical cavopulmonary assist; Pediatric circulatory support; Single-ventricle physiology; Ventricular assist device