title: Advanced glycation end-products and receptor for advanced glycation end-products expression in patients with idiopathic pulmonary fibrosis and NSIP.
abstract: Advanced glycation end products (AGEs) are associated with the pathogenesis of various diseases. AGEs induce excess accumulation of extracellular matrix and expression of profibrotic cytokines. In addition, studies on receptor for advanced glycation end products (RAGE) have shown that the ligand-RAGE interaction activates several intracellular signaling cascades associated with several fibrotic diseases. We investigated the expression of AGEs and RAGE in samples from patients with idiopathic pulmonary fibrosis (IPF) and non-specific interstitial pneumonia (NSIP). Lung tissues and plasma samples from patients with IPF (n=10), NSIP (n=10), and control subjects (n=10) were obtained. Expression of AGEs and RAGE was determined by immunofluorescence assay of lung tissue. Circulating AGEs were measured by Western blot and enzyme-linked immunosorbent assay. Lungs with IPF showed strong expression for both AGEs and RAGE compared to that in NSIP and controls. However, no difference in AGE or RAGE expression was observed in lungs with NSIP compared to that in the controls. Levels of circulating AGEs also increased significantly in lungs of patients with IPF compared to those with NSIP and normal control. Increased AGE-RAGE interaction may play an important role in the pathogenesis of IPF.
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center Incheon, Republic of Korea.
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kyung
authors.affiliation: Department of Anatomy, Gachon University of Medicine and Science Incheon, Republic of Korea.
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Byun
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center Incheon, Republic of Korea.
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Yoon
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center Incheon, Republic of Korea.
authors.forename: Yu Jin
authors.initials: YJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center Incheon, Republic of Korea.
authors.forename: Sang Pyo
authors.initials: SP
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center Incheon, Republic of Korea.
authors.forename: Jeong-Woong
authors.initials: JW
authors.lastname: Park
authors.affiliation: Department of Anatomy, Gachon University of Medicine and Science Incheon, Republic of Korea.
authors.forename: Bong Hee
authors.initials: BH
authors.lastname: Lee
authors.affiliation: Genome Research Center for Allergy and Respiratory diseases, Soonchunhyang University Bucheon Hospital Bucheon, Republic of Korea.
authors.forename: Jong Sook
authors.initials: JS
authors.lastname: Park
authors.affiliation: Genome Research Center for Allergy and Respiratory diseases, Soonchunhyang University Bucheon Hospital Bucheon, Republic of Korea.
authors.forename: An Soo
authors.initials: AS
authors.lastname: Jang
authors.affiliation: Genome Research Center for Allergy and Respiratory diseases, Soonchunhyang University Bucheon Hospital Bucheon, Republic of Korea.
authors.forename: Choon Sik
authors.initials: CS
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Gachon University Gil Medical Center Incheon, Republic of Korea.
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Jeong
mesh_terms: D000368:Aged; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005455:Fluorescent Antibody Technique; D017127:Glycation End Products, Advanced / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D054990:Idiopathic Pulmonary Fibrosis / Q000378:metabolism*; D017563:Lung Diseases, Interstitial / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000032:analysis / Q000096:biosynthesis*
chemical_list: D017127:Glycation End Products, Advanced; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic
keywords: Advanced glycation end products; Idiopathic pulmonary fibrosis; receptor for advanced glycation end product