title: Canine pancreatic islet cell tumours secreting insulin-like growth factor type 2: a rare entity.
abstract: Insulin-like growth factor type II (IGF-II) is the main cause of non-islet cell tumour hypoglycaemia (NICTH) and insulin is thought to be the only factor causing hypoglycaemia in insulinomas. However, two case reports of pancreatic neuroendocrine tumours (PNETs) producing IGF-II have been previously published: a human and a canine patient. In this study, we investigated clinical, histopathological, immunohistochemical and ultrastructural features, and biological behaviour of canine pancreatic IGF-II-omas, a subgroup of PNETs that has not been previously characterized. Case records of 58 dogs with confirmed PNETs and hypoglycaemia were reviewed: six patients were affected by IGF-II-omas. Surgery was performed in all cases and two dogs had metastases. Four patients remained alive and in remission at 370, 440, 560 and 890 days post-diagnosis; two died of non-tumour-related causes. IGF-II-omas can be differentiated from insulinomas through hypoinsulinaemia, IGF-II positive and insulin negative immunostaining. The prevalence of this neoplasia is low, accounting for just 6% of PNETs.
authors.affiliation: Small Animal Teaching Hospital, School of Veterinary Sciences, University of Liverpool, Liverpool, UK.
authors.forename: R
authors.initials: R
authors.lastname: Finotello
authors.affiliation: Section of Veterinary Pathology, School of Veterinary Sciences, University of Liverpool, Liverpool, UK.
authors.forename: L
authors.initials: L
authors.lastname: Ressel
authors.affiliation: Department of Internal Medicine and Medical Specialities, University of Genova, Genova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Arvigo
authors.affiliation: Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Baroni
authors.affiliation: Department of Veterinary Sciences, Veterinary Teaching Hospital, University of Pisa, Pisa, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Marchetti
authors.affiliation: Clinica Veterinaria Nerviano, Milan, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Romanelli
authors.affiliation: Small Animal Teaching Hospital, School of Veterinary Sciences, University of Liverpool, Liverpool, UK.
authors.forename: R
authors.initials: R
authors.lastname: Burrow
authors.affiliation: Clinica Veterinaria Roma Sud, Rome, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Mignacca
authors.affiliation: Small Animal Teaching Hospital, School of Veterinary Sciences, University of Liverpool, Liverpool, UK.
authors.forename: L
authors.initials: L
authors.lastname: Blackwood
mesh_terms: D007516:Adenoma, Islet Cell / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000235:genetics / Q000378:metabolism*; D004285:Dogs; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000378:metabolism*; D008297:Male; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*; D012189:Retrospective Studies
chemical_list: D007335:Insulin-Like Growth Factor II
keywords: IGF-II; dog; hypoglycaemia; insulin growth factor-II; insulinoma; islet cell tumour