title: The role of plasma IDO activity as a diagnostic marker of patients with colorectal cancer.
abstract: High levels of indoleamine 2,3-dioxygenase (IDO) are involved in tumour escape mechanisms. The aim of this study is the evaluation of L-kynurenine of plasma as marker of diagnostic and prognostic in patients with colorectal cancer. The study included 78 patients with colorectal cancer, of whom 15 % were in stage I/II, 30 % in stage III, and 55 % in stage IV, and was compared with a control group of 70 healthy subjects. The receiver operating characteristic (ROC) curve analysis showed an area under the curve of 0.917, with a specificity of 100 % and with a sensitivity to detect cancer of the colon of 85.2 %, taking 1.83 μM as a cut-off point. The overall survival analysis also indicated that patients with low levels of L-kynurenine in plasma increased survival rate after 45 months of follow-up (P = 0.032). These results show that the plasma levels of L-kynurenine could be a good biomarker to differentiate individuals with colorectal cancer from healthy individuals.
authors.affiliation: Research Unit, University Hospital of Burgos, Burgos, Spain, cavia@hgy.es.
authors.forename: M
authors.initials: M
authors.lastname: Cavia-Saiz
authors.forename: P
authors.initials: P
authors.lastname: Muñiz Rodríguez
authors.forename: B
authors.initials: B
authors.lastname: Llorente Ayala
authors.forename: M
authors.initials: M
authors.lastname: García-González
authors.forename: M J
authors.initials: MJ
authors.lastname: Coma-Del Corral
authors.forename: C
authors.initials: C
authors.lastname: García Girón
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000628:therapy; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve
chemical_list: D014408:Biomarkers, Tumor; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase