title: Effects of sevoflurane and propofol on right ventricular function and pulmonary circulation in patients undergone esophagectomy.
abstract: OBJECTIVE
  Sevoflurane and propofol are both widely used in clinical anesthesia. The aim of this study is to compare the effects of sevoflurane and propofol on right ventricular function and pulmonary circulation in patients receiving esophagectomy.
  
  
  METHODS
  Forty adult patients undergoing an elective open-chest thoracotomy for esophagectomy were randomized to receive either propofol (n=20) or sevoflurane (n=20) as the main anesthetic agent. The study was performed in Changzheng Hospital. Hemodynamic data were recorded at specific intervals: before the surgery (T0), BIS values reaching 40 after anesthesia induction (T1), two-lung ventilation (T2), ten minutes after one-lung ventilation (T3), the end of the operation (T4) using PiCCO2 and Swan-Ganz catheter.
  
  
  RESULTS
  CI, RVEF, RVSWI and RVEDVI were significantly smaller in propofol group than those in sevoflurane group throughout the surgery (P<0.05). However, SVRI was significantly greater in propofol group than that in sevoflurane group (P<0.05). Compared with the patients in propofol group, the patients who received sevoflurane had a greater reduction in OI and increase in Os/Ot (P<0.05). And, PVRI was significantly smaller in sevoflurane group than in propofol group (P<0.05).
  
  
  CONCLUSIONS
  Anesthesia with sevoflurane preserved better right ventricular function than propofol in patients receiving esophagectomy. However, propofol improved oxygenation and shunt fraction during one-lung ventilation compared with sevoflurane anesthesia. To have the best effect, anesthesiologists can choose the two anesthetics flexibly according to the monitoring results.
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of China.
authors.forename: Wen-Yun
authors.initials: WY
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Wang
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of China.
authors.forename: Hai-Tao
authors.initials: HT
authors.lastname: Xu
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of China.
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Yuan
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of China.
authors.forename: Hai-Jing
authors.initials: HJ
authors.lastname: Sun
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of China.
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Dun
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of China.
authors.forename: Shuang-Qiong
authors.initials: SQ
authors.lastname: Zhou
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of China.
authors.forename: Zui
authors.initials: Z
authors.lastname: Zou
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University 415 Fengyang Road, Shanghai, People's Republic of China.
authors.forename: Xue-Yin
authors.initials: XY
authors.lastname: Shi
mesh_terms: D000777:Anesthetics / Q000009:adverse effects*; D016629:Esophagectomy / Q000379:methods*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects*; D011652:Pulmonary Circulation / Q000187:drug effects*; D000077149:Sevoflurane; D016278:Ventricular Function, Right / Q000187:drug effects*
chemical_list: D000777:Anesthetics; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol
keywords: Sevoflurane; esophagectomy; propofol; pulmonary circulation; right ventricular function