title: Pros and cons of methods used for the prediction of oral drug absorption.
abstract: Oral drug administration can be problematic owing to the specific physicochemical characteristics of new chemical entities. Assessment of the possibility of a new active compound to be administered orally, as well as of the requirements for a successful oral administration (type of dosage form, dosing conditions), constitute a substantial burden during the drug-discovery and drug-development process. Throughout drug development, in silico, in vitro, in vivo and integrated dynamic models play an important role for the decision making in absorption-related issues. In this review, the most common methods used for the prediction of oral drug absorption as a stage development approach are discussed.
authors.affiliation: Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. n.fotaki@bath.ac.uk.
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Fotaki