title: [Basics of topical therapy].
abstract: Numerous dermatoses are treated with topically applied substances. Planning, conception, implementation and monitoring of topical therapies are dermatological core competencies. This requires fundamental knowledge about the physicochemical structure of skin layers, especially the stratum corneum, as well as about the interaction of both the active substance and the vehicle system with the skin. Professional treatment also requires basic knowledge about pharmacokinetics and the special features of epicutaneous drug administration.
authors.affiliation: Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle (Saale), Deutschland, johannes.wohlrab@medizin.uni-halle.de.
authors.forename: J
authors.initials: J
authors.lastname: Wohlrab
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D003879:Dermatologic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D019317:Evidence-Based Medicine; D006801:Humans; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D012871:Skin Diseases / Q000188:drug therapy* / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D003879:Dermatologic Agents