title: Multiple bonds for the lipid interest.
abstract: Polyene lipids and alkyne lipids allow study of lipid organization, dynamics and metabolism. Both types of lipids contain multiple bonds as the essential functional group, leading to minimal disturbance of the hydrophobic properties on which the characteristic behavior of lipids is based. Polyene lipids can directly be traced due to their intrinsic fluorescence, while alkyne lipids need the copper-catalyzed click reaction to an azido-reporter for detection. This review describes recent developments in synthesis and application of both types of lipid analogs with emphasis on metabolic tracing and microscopy imaging. This article is part of a Special Issue entitled Tools to study lipid functions.
authors.affiliation: Life & Medical Sciences Institute (LIMES), University of Bonn, Carl-Troll-Str. 31, D-53115 Bonn, Germany. Electronic address: lars.kuerschner@uni-bonn.de.
authors.forename: Lars
authors.initials: L
authors.lastname: Kuerschner
authors.affiliation: Life & Medical Sciences Institute (LIMES), University of Bonn, Carl-Troll-Str. 31, D-53115 Bonn, Germany. Electronic address: cthiele@uni-bonn.de.
authors.forename: Christoph
authors.initials: C
authors.lastname: Thiele
mesh_terms: D000480:Alkynes / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry*; D011090:Polyenes / Q000737:chemistry
chemical_list: D000480:Alkynes; D008055:Lipids; D011090:Polyenes
keywords: Alkyne lipid; Analog; Click lipid; Click-reaction; Polyene lipid; Probe