title: Alder-Reilly Anomaly in Hurler's Syndrome in a Neonate: A Rare Case Report.
abstract: A 22-days-old male newborn baby presented with persistence of neonatal jaundice since birth. On clinical examination he had coarse facial features, a prominent forehead, enlarged tongue, icterus, hepatosplenomegaly, skeletal deformities and bilateral inguinal hernia. On investigation the peripheral smear revealed Alder-Reilly anomaly in the neutrophils suggesting mucopolysaccharidosis. Mucopolysaccharide excretion spot test of the urine was positive; and an assay for glycosaminoglycans in the urine was also high, which confirmed the clinical diagnosis of Hurler's syndrome. We present this rare case to highlight the association of Alder-Reilly anomaly and bilateral inguinal hernia in Hurler's syndrome even in neonates.
authors.affiliation: Department of Pathology, S.C.B. Medical College, Cuttack, 753007 Orissa India.
authors.forename: Pallavi
authors.initials: P
authors.lastname: Bhuyan
authors.affiliation: Department of Pediatrics, S.C.B. Medical College, Cuttack, India.
authors.forename: Bipsa
authors.initials: B
authors.lastname: Singh
authors.affiliation: Department of Pathology, ITER & SUM Hospital, Bhubaneswar, India.
authors.forename: Sukumar
authors.initials: S
authors.lastname: Chakrabarty
authors.affiliation: Department of Pediatrics, S.C.B. Medical College, Cuttack, India.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Mohanty
authors.affiliation: Department of Pediatrics, S.C.B. Medical College, Cuttack, India.
authors.forename: Mukesh
authors.initials: M
authors.lastname: Agarwal
authors.affiliation: Department of Gynecology, Hi-Tech Medical College, Bhubaneswar, India.
authors.forename: Sanghamitra
authors.initials: S
authors.lastname: Satpathy
keywords: Alder–Reilly anomaly; Bilateral inguinal hernia; Hurler’s syndrome; Mucopolysaccharidosis (MPS) type 1