title: Glucose metabolism in the primary auditory cortex of postlingually deaf patients: an FDG-PET study.
abstract: OBJECTIVE
  Previous FDG-PET studies have indicated neuroplasticity in the adult auditory cortex in cases of postlingual deafness. In the mature brain, auditory deprivation decreased neuronal activity in primary auditory and auditory-related cortices. In order to reevaluate these issues, we used statistical analytic software, namely a three-dimensional stereotaxic region of interest template (3DSRT), in addition to statistical parametric mapping (SPM; Institute of Neurology, University College of London, UK).
  
  
  METHODS
  (18)F-FDG brain PET scans were performed on 7 postlingually deaf patients and 10 healthy volunteers. Significant increases and decreases of regional cerebral glucose metabolism in the patient group were estimated by comparing their PET images with those of healthy volunteers using SPM analysis and 3DSRT.
  
  
  RESULTS
  SPM revealed that the glucose metabolism of the deaf patients was lower in the right superior temporal gyrus, both middle temporal gyri, left inferior temporal gyrus, right inferior lobulus parietalis, right posterior cingulate gyrus, and left insular cortex than that of the control subjects. 3DSRT data also revealed significantly decreased glucose metabolism in both primary auditory cortices of the postlingually deaf patients.
  
  
  CONCLUSIONS
  SPM and 3DSRT analyses indicated that glucose metabolism decreased in the primary auditory cortex of the postlingually deaf patients. The previous results of PET studies were confirmed, and our method involving 3DSRT has proved to be useful.
authors.affiliation: Departments of Otolaryngology - Head and Neck Surgery, Miyazaki University School of Medicine, Miyazaki, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Okuda
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nagamachi
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Ushisako
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tono
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D001303:Auditory Cortex / Q000000981:diagnostic imaging* / Q000378:metabolism*; D019929:Cochlear Implantation; D003638:Deafness / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D007839:Functional Laterality / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009473:Neuronal Plasticity / Q000502:physiology; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D005947:Glucose