title: Preventing surgery-induced NK cell dysfunction and cancer metastases with influenza vaccination.
abstract: Surgical resection is the mainstay of treatment for solid tumors, but the postoperative period is uniquely inclined to the formation of metastases, largely due to the suppression of natural killer (NK) cells. We found that preoperative influenza vaccination prevents postoperative NK-cell dysfunction, attenuating tumor dissemination in murine models and promoting the activation of NK cells in cancer patients.
authors.affiliation: Centre for Innovative Cancer Research; Ottawa Hospital Research Institute; Ottawa, Canada.
authors.forename: Lee-Hwa
authors.initials: LH
authors.lastname: Tai
authors.affiliation: Centre for Innovative Cancer Research; Ottawa Hospital Research Institute; Ottawa, Canada ; Department of Cellular and Molecular Medicine; University of Ottawa; Ottawa, Canada ; Department of Neurosurgery; The Second Hospital of Shandong University; Shandong, China.
authors.forename: Jiqing
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Centre for Innovative Cancer Research; Ottawa Hospital Research Institute; Ottawa, Canada ; Department of Surgery; University of Ottawa; Ottawa, Canada ; Department of Biochemistry, Microbiology, and Immunology; University of Ottawa; Ottawa, Canada.
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Auer
keywords: cancer metastases; immunosuppression; influenza vaccine; natural killer cells; surgical stress