title: A new role for NFκB in immunosurveillance and its implications for cancer immunotherapy.
abstract: The activation of NFκB in the tumor microenvironment is associated with inflammatory responses that promote disease progression. We have recently found that the activation of NFκB in the tumor also regulates T cell-mediated immune responses, hence actively participating in cancer immunosurveillance. These findings call for reassessment of the function of NFκB within neoplastic lesions and open novel perspectives for anticancer immunotherapy.
authors.affiliation: Department of Immunology; Moffitt Cancer Center; Tampa, FL USA.
authors.forename: Amer A
authors.initials: AA
authors.lastname: Beg
authors.affiliation: Department of Immunology; Moffitt Cancer Center; Tampa, FL USA ; Atta ur Rehman School of Applied Biosciences (ASAB); National University of Science and Technology (NUST); Islamabad, Pakistan.
authors.forename: Tahira
authors.initials: T
authors.lastname: Khan
authors.affiliation: Department of Immunology; Moffitt Cancer Center; Tampa, FL USA ; Department of Thoracic Oncology; Moffitt Cancer Center; Tampa, FL USA.
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Antonia
keywords: Immunotherapy; NFκB; chemokines; immunosurveillance; inflammation; lung cancer