title: Cerebral blood flow is an earlier indicator of perfusion abnormalities than cerebral blood volume in Alzheimer's disease.
abstract: The purpose of this study was to elucidate whether cerebral blood flow (CBF) can better characterize perfusion abnormalities in predementia stages of Alzheimer's disease (AD) than cerebral blood volume (CBV) and whether cortical atrophy is more associated with decreased CBV or with decreased CBF. We compared measurements of CBV, CBF, and mean cortical thickness obtained from magnetic resonance images in a group of healthy controls, patients with mild cognitive impairment (MCI) who converted to AD after 2 years of clinical follow-up (MCI-c), and patients with mild AD. A significant decrease in perfusion was detected in the parietal lobes of the MCI-c patients with CBF parametric maps but not with CBV maps. In the MCI-c group, a negative correlation between CBF values and cortical thickness in the right parahippocampal gyrus suggests an increase in CBF that depends on cortical atrophy in predementia stages of AD. Our study also suggests that CBF deficits appear before CBV deficits in the progression of AD, as CBV abnormalities were only detected at the AD stage, whereas CBF changes were already detected in the MCI stage. These results confirm the hypothesis that CBF is a more sensitive parameter than CBV for perfusion abnormalities in MCI-c patients.
authors.affiliation: 1] Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Leganés, Madrid, Spain [2] Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain [3] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
authors.forename: María
authors.initials: M
authors.lastname: Lacalle-Aurioles
authors.affiliation: 1] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain [2] Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
authors.forename: José M
authors.initials: JM
authors.lastname: Mateos-Pérez
authors.affiliation: Servicio de Radiodiagnóstico. Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Juan A
authors.initials: JA
authors.lastname: Guzmán-De-Villoria
authors.affiliation: Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Olazarán
authors.affiliation: Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Cruz-Orduña
authors.affiliation: 1] Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain [2] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Alemán-Gómez
authors.affiliation: Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
authors.forename: María-Elena
authors.initials: ME
authors.lastname: Martino
authors.affiliation: 1] Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, Leganés, Madrid, Spain [2] Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain [3] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology; D001783:Blood Flow Velocity / Q000502:physiology*; D001810:Blood Volume / Q000502:physiology*; D001811:Blood Volume Determination; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D060825:Cognitive Dysfunction / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000523:psychology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D055420:Perfusion Imaging; D011446:Prospective Studies