title: Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions.
abstract: Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity.
authors.affiliation: Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, 3663 North Zhongshan Rd., Shanghai, China. syliu@sist.ecnu.edu.cn whu@chem.ecnu.edu.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: Qiu
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.forename: Chaoqun
authors.initials: C
authors.lastname: Ma
authors.forename: Huang
authors.initials: H
authors.lastname: Qiu
authors.forename: Shunying
authors.initials: S
authors.lastname: Liu
authors.forename: Liping
authors.initials: L
authors.lastname: Yang
authors.forename: Wenhao
authors.initials: W
authors.lastname: Hu
mesh_terms: D000080:Acetals / Q000138:chemical synthesis / Q000737:chemistry*; D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D018360:Crystallography, X-Ray; D008670:Metals / Q000737:chemistry*; D008968:Molecular Conformation; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000080:Acetals; D000143:Acids; D056831:Coordination Complexes; D008670:Metals; D012238:Rhodium