title: Primary intravascular large B cell lymphoma of the endometrium.
abstract: Primary intravascular large B cell lymphoma (IVLBCL) of the endometrium is extremely rare. So far, only 5 cases have been reported in the English literature. We now report a new case of endometrial IVLBCL which exhibited distinct clinicopathological characteristics and meaningful laboratory tests, and also review the literature. A 66-year-old woman showed symptoms of chronic cough and choking sensation for 4 months. Following three days of vaginal bleeding she presented for examination and diagnosis. The percentage of monocytes in the blood was double that of normal levels. There was a polyp in the endometrium, which showed a number of medium-large lymphoid cells in dilated capillaries. Immunohistochemically, the lymphoid cells were immunoreactive to CD20, CD79a, Mum-1 and Foxp-1 with 85% cells immunoreactive to Ki-67. IVLBCL of the endometrium is rare and the clinical diagnosis is very difficult. Unexplained fever of old people and abnormal laboratory tests such as obvious abnormal monocyte distribution in the blood should alert the clinical doctor to the possibility of IVLBCL. A correct diagnosis mainly depends on pathological tests and immunohistochemical labeling. The prognosis of IVLBCL is poor and few patients survive longer than one year.
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, PR China; Department of Pathology, Medical College, Qingdao University, Qingdao, PR China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Department of Vascular Surgery, The Affiliated Hospital of Qingdao University, Qingdao, PR China.
authors.forename: Yuewei
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, PR China. Electronic address: chingyx93@126.com.
authors.forename: Yanxia
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, PR China. Electronic address: wenjuan801023@163.com.
authors.forename: Wenjuan
authors.initials: W
authors.lastname: Yu
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, PR China.
authors.forename: Yujun
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, PR China; Department of Pathology, Medical College, Qingdao University, Qingdao, PR China.
authors.forename: Fenggang
authors.initials: F
authors.lastname: Xiang
authors.affiliation: Department of Pathology, The Affiliated Hospital of Qingdao University, Qingdao, PR China; Department of Pathology, Medical College, Qingdao University, Qingdao, PR China.
authors.forename: Chengqin
authors.initials: C
authors.lastname: Wang
mesh_terms: D000368:Aged; D016889:Endometrial Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D004717:Endometrium / Q000473:pathology*; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000473:pathology*
keywords: Endometrium; Intravascular large B cell lymphoma