title: From proliferation to proliferation: monocyte lineage comes full circle.
abstract: Monocytes are mononuclear circulating phagocytes that originate in the bone marrow and give rise to macrophages in peripheral tissue. For decades, our understanding of monocyte lineage was bound to a stepwise model that favored an inverse relationship between cellular proliferation and differentiation. Sophisticated molecular and surgical cell tracking tools have transformed our thinking about monocyte topo-ontogeny and function. Here, we discuss how recent studies focusing on progenitor proliferation and differentiation, monocyte mobilization and recruitment, and macrophage differentiation and proliferation are reshaping knowledge of monocyte lineage in steady state and disease.
authors.affiliation: Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA, fswirski@mgh.harvard.edu.
authors.forename: Filip K
authors.initials: FK
authors.lastname: Swirski
authors.forename: Ingo
authors.initials: I
authors.lastname: Hilgendorf
authors.forename: Clinton S
authors.initials: CS
authors.lastname: Robbins
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D049109:Cell Proliferation; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D055017:Monocyte-Macrophage Precursor Cells / Q000166:cytology / Q000378:metabolism; D009000:Monocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D010586:Phagocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism