title: Vascular endothelial growth factor receptor-1 expression in breast cancer and its correlation to vascular endothelial growth factor a.
abstract: VEGF-A is the most potent angiogenic factor in tumour angiogenesis. Its effects are mediated via two receptors VEGFR-1 and VEGFR-2. Primary aim of our study was to examine the expression of VEGFR-1 in breast cancer and its correlation to VEGF expression, lymph node status, tumour size, histological grade, and hormone receptor status. To examine the VEGFR-1 and VEGF expressions in tumour and surrounding tissue of 51 breast cancer patients, and in healthy breast tissue of 30 benign breast diseases patients, we used three-step immunohistochemical staining. VEGFR-1 and VEGF expressions were significantly increased in breast cancer tumour in relation to surrounding tissue (P < 0.01), and the VEGF expression was significantly increased in lymph node positive breast cancer patients (P < 0.01). VEGFR-1 and VEGF expressions were significantly higher in breast cancer tumour compared with healthy breast tissue (P < 0.01). Significant correlation between VEGF and VEGFR-1 expressions was found (P < 0.05). No significant correlations between VEGF and VEGFR-1 expressions and tumour size, histological grade, and hormone receptor status were found. Increased expression of VEGFR-1 and VEGF in breast cancer tumour and significant correlation between these proteins suggest the possible role of VEGF/VEGFR-1 signalization in breast cancer development, although VEGFR-1 potential prognostic value was not confirmed.
authors.affiliation: Department of Biochemistry, University of Tuzla, 75 000 Tuzla, Bosnia And Herzegovina.
authors.forename: Nahida
authors.initials: N
authors.lastname: Srabovic
authors.affiliation: Department of Biochemistry, University of Tuzla, 75 000 Tuzla, Bosnia And Herzegovina.
authors.forename: Zlata
authors.initials: Z
authors.lastname: Mujagic
authors.affiliation: Policlinic of Laboratory Diagnostics, Department of Pathology, University Clinical Centre of Tuzla, 75 000 Tuzla, Bosnia And Herzegovina.
authors.forename: Jasminka
authors.initials: J
authors.lastname: Mujanovic-Mustedanagic
authors.affiliation: Department of Biochemistry, University of Tuzla, 75 000 Tuzla, Bosnia And Herzegovina.
authors.forename: Adaleta
authors.initials: A
authors.lastname: Softic
authors.affiliation: Policlinic of Laboratory Diagnostics, Department of Pathology, University Clinical Centre of Tuzla, 75 000 Tuzla, Bosnia And Herzegovina.
authors.forename: Zdeno
authors.initials: Z
authors.lastname: Muminovic
authors.affiliation: Policlinic of Surgery, University Clinical Centre Tuzla, 75 000 Tuzla, Bosnia And Herzegovina.
authors.forename: Adi
authors.initials: A
authors.lastname: Rifatbegovic
authors.affiliation: Department of Biochemistry, University of Tuzla, 75 000 Tuzla, Bosnia And Herzegovina.
authors.forename: Lejla
authors.initials: L
authors.lastname: Begic