title: Antibiotic-induced cardiac arrhythmias.
abstract: This review aims to clarify the underlying risk of arrhythmia associated with the use of macrolides and fluoroquinolones antibiotics. Torsades de pointes (TdP) is a rare potential side effect of fluoroquinolones and macrolide antibiotics. However, the widespread use of these antibiotics compounds the problem. These antibiotics prolong the phase 3 of the action potential and cause early after depolarization and dispersion of repolarization that precipitate TdP. The potency of these drugs, as potassium channel blockers, is very low, and differences between them are minimal. Underlying impaired cardiac repolarization is a prerequisite for arrhythmia induction. Impaired cardiac repolarization can be congenital in the young or acquired in adults. The most important risk factors are a prolonged baseline QTc interval or a combination with class III antiarrhythmic drugs. Modifiable risk factors, including hypokalemia, hypomagnesemia, drug interactions, and bradycardia, should be corrected. In the absence of a major risk factor, the incidence of TdP is very low. The use of these drugs in the appropriate settings of infection should not be altered because of the rare risk of TdP, except among cases with high-risk factors.
authors.affiliation: Department of Cardiovascular Diseases, University of Cincinnati, Cincinnati, OH, USA.
authors.forename: Elsayed
authors.initials: E
authors.lastname: Abo-Salem
authors.forename: John C
authors.initials: JC
authors.lastname: Fowler
authors.forename: Mehran
authors.initials: M
authors.lastname: Attari
authors.forename: Craig D
authors.initials: CD
authors.lastname: Cox
authors.forename: Alejandro
authors.initials: A
authors.lastname: Perez-Verdia
authors.forename: Ragesh
authors.initials: R
authors.lastname: Panikkath
authors.forename: Kenneth
authors.initials: K
authors.lastname: Nugent
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004347:Drug Interactions; D004562:Electrocardiography / Q000187:drug effects; D024841:Fluoroquinolones / Q000009:adverse effects; D006801:Humans; D018942:Macrolides / Q000009:adverse effects; D016171:Torsades de Pointes / Q000139:chemically induced*
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D018942:Macrolides
keywords: Antibiotics; Fluoroquinolones; Macrolides; QT interval; Torsade de pointes