title: Interleukin-22: a likely target for treatment of autoimmune diseases.
abstract: Interleukin-22 (IL-22) is a member of IL-10 family cytokines that is produced by many different types of lymphocytes including both those of the innate and adaptive immune systems. This includes activated T cells, most notably Th17 and Th22 cells, and NK cells, γδ T cells, LTi cells and LTi-like cells. IL-22 mediates its effects via the IL-22-IL-22R complex and subsequent Janus kinase-signal transducer and activators of transcription (JAK-STAT) signaling pathway. Recently accumulated evidence has indicated that IL-22 also plays an important role in the pathogenesis of many autoimmune diseases. In this review, we discuss the recent findings and advancement of the role for IL-22 in several autoimmune diseases, such as psoriasis, rheumatoid arthritis (RA), hepatitis, graft versus host disease (GHVD) and allergic diseases, implicating that target IL-22 may have a therapeutic potential in those autoimmune diseases.
authors.affiliation: Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, PR China. Electronic address: yangxuyan@163.com.
authors.forename: Xuyan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Division of Rheumatology, Department of Medicine at Penn State University Hershey College of Medicine, Hershey 17033, USA. Electronic address: szheng1@hmc.psu.edu.
authors.forename: Song Guo
authors.initials: SG
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism; D007378:Interleukins / Q000276:immunology* / Q000627:therapeutic use; D018123:Receptors, Interleukin / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D000097043:Interleukin-22
chemical_list: D020381:Interleukin-17; D007378:Interleukins; D018123:Receptors, Interleukin; D000097043:Interleukin-22; C415369:interleukin-22 receptor
keywords: Autoimmunity; Cytokine receptor; Innate immunity; Interleukin-22; Signal pathway; T-helper cell