title: Should GLP-1 receptor agonists be used with caution in high risk population for colorectal cancer?
abstract: Glucagon-like peptide-1 (GLP-1) receptor agonists, with few reported side effects, are a kind of very promising anti-diabetes drugs. They are thus being paid high hopes on by both doctors and patients. GLP-1 receptor agonists, however, have not been used in clinic for a long time. Some unknown potential adverse effects may exist. Because GLP-1 receptor agonists enhance β cells proliferation in pancreas via influencing Wnt/β-catenin pathway, a pathway which is associated with tumorigenesis in colon, we then assume that GLP-1 receptor agonists may increase the risk for colorectal cancer.
authors.affiliation: Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Fan
authors.affiliation: Department of Pharmacy, No. 309 Hospital of PLA, PR China.
authors.forename: Jin
authors.initials: J
authors.lastname: Meng
authors.affiliation: Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China.
authors.forename: Dian
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, Shaanxi, PR China. Electronic address: qbmei53@hotmail.com.
authors.forename: Qibing
authors.initials: Q
authors.lastname: Mei
mesh_terms: D015179:Colorectal Neoplasms / Q000503:physiopathology*; D003920:Diabetes Mellitus / Q000188:drug therapy; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D018027:Receptors, Glucagon / Q000819:agonists*; D012307:Risk Factors
chemical_list: C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D018027:Receptors, Glucagon