title: Extranodal lymphoma with peripheral nervous system involvement in a dog.
abstract: An 8-year-old neutered female Cavalier King Charles spaniel was evaluated for progressing right forelimb lameness. Magnetic resonance imaging revealed that the right-side radial nerves and the caudal brachial plexus were swollen. The histological and molecular biological diagnosis by partial biopsy of the C8 spinal nerve was T-cell lymphoma. Coadministration of lomustine and irradiation was started. However, this therapy was ineffective. At necropsy, neoplastic tissues were seen extending into the subarachnoid space of the spinal cord, liver, pancreas and kidneys as gross findings. A large mass was also identified occupying the caudal thorax. Histologic findings included infiltration in these organs and the mass by neoplastic lymphocytes. To date, involvement of peripheral nerves (neurolymphomatosis) is rarely reported in veterinary species.
authors.affiliation: Department of Orthopedic and Neurosurgery, School of Veterinary Medicine, Rakuno Gakuen University, Bunkyo-dai Midori-machi 582 Ebetsu, Hokkaido 069-8501, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueno
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Miyoshi
authors.forename: Sho
authors.initials: S
authors.lastname: Fukui
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kondo
authors.forename: Kazuya
authors.initials: K
authors.lastname: Matsuda
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Uchide
mesh_terms: D000818:Animals; D001917:Brachial Plexus / Q000473:pathology; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology* / Q000532:radiotherapy*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D008130:Lomustine / Q000627:therapeutic use*; D054391:Lymphoma, Extranodal NK-T-Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D013127:Spinal Nerves / Q000473:pathology
chemical_list: D008130:Lomustine