title: Treatment of pure uterine sarcoma at the Institut Català D'Oncologia.
abstract: OBJECTIVE
  The aim of this retrospective study was to investigate the clinical and histopathological characteristics of the disease and treatment outcome of patients with pure uterine sarcomas.
  
  
  BACKGROUND
  Uterine sarcomas are especially rare tumours, comprising only 3-5% of uterine cancers. They are characterized by histopathological diversity, rapid clinical progression, and poor prognosis. Optimal management consists of complete surgical removal and adjuvant radiotherapy may improve the prognosis.
  
  
  METHODS
  All patients with pure uterine sarcoma histology treated at our centre, the Institut Català D'Oncologia in Barcelona Spain, between 2002 and 2010 were reviewed.
  
  
  RESULTS
  Records of 17 patients treated at our hospital over an 8-year period were obtained. Nine patients (53%) had leiomyosarcoma, 7 (41%) had endometrial stromal sarcoma, and 1 patient had unclassified sarcoma. All patients were treated with external beam radiation after surgical excision. Mean age was 62 years (range, 51-69 years). Of the 17 patients, 13 (76%) presented with stage I disease, 2 (12%) were stage II, and 2 (12%) stage III. The overall actuarial 2-year survival estimate was 82.5%. Two patients experienced local relapse. The 2-year local control rate was 90%. A total of 5 patients experienced either local or metastatic relapse. The 2-year progression free survival rate was 58%.
  
  
  CONCLUSIONS
  In our experience, combined treatment (surgery and adjuvant radiation therapy) is effective with acceptable side effects. Larger and multicenter studies are needed to assess treatment outcome for pure uterine sarcoma histology.
authors.affiliation: Radiation Oncology Department at the Instituto Português de Oncologia de Lisboa, Francisco Gentil, Portugal.
authors.forename: Gonçalo
authors.initials: G
authors.lastname: Fernandez
authors.affiliation: Radiation Oncology Department at the Institut Català d'Oncologia (ICO), Hospitalet de Belltvige, Barcelona, Spain.
authors.forename: Susanna Marín I
authors.initials: SM
authors.lastname: Borràs
authors.affiliation: Unidad de Investigación Clínica at the Institut Català d'Oncologia (ICO), Hospitalet de Belltvige, Barcelona, Spain.
authors.forename: Valentín Navarro
authors.initials: VN
authors.lastname: Pérez
authors.affiliation: Radiation Oncology Department at the Institut Català d'Oncologia (ICO), Hospitalet de Belltvige, Barcelona, Spain.
authors.forename: Ferran
authors.initials: F
authors.lastname: Guedea
keywords: Gynecology; Pure uterine sarcoma; Radiotherapy