title: Toxicity of nano molybdenum trioxide toward invasive breast cancer cells.
abstract: Current chemotherapy is limited by the nature of invasive cancer cells, which are similar to cancer stem cells. Nanomaterials provide a potential alternate mode of cancer therapy. This study investigated the cytotoxicity of molybdenum trioxide (MoO3) nanoplates toward invasive breast cancer iMCF-7 cells by analyzing morphological changes and performing Western blot and flow cytometry analyses. The findings suggested that MoO3 exposure induces apoptosis and generates reactive oxygen species (ROS) in iMCF-7 cells. This study revealed the potential utility of MoO3 for treating metastatic cancer cells, which might enable advancements in cancer therapy.
authors.affiliation: Faculty of Biotechnology, College of Applied Life Sciences , Jeju National University , Jeju, Jeju - 690 756, Republic of Korea.
authors.forename: Thao
authors.initials: T
authors.lastname: Anh Tran
authors.forename: Karthikeyan
authors.initials: K
authors.lastname: Krishnamoorthy
authors.forename: Yeon Woo
authors.initials: YW
authors.lastname: Song
authors.forename: Somi Kim
authors.initials: SK
authors.lastname: Cho
authors.forename: Sang Jae
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D015153:Blotting, Western; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D061986:MCF-7 Cells; D053768:Metal Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D008982:Molybdenum / Q000737:chemistry / Q000633:toxicity*; D009361:Neoplasm Invasiveness; D010087:Oxides / Q000737:chemistry / Q000633:toxicity*; D014961:X-Ray Diffraction
chemical_list: D010087:Oxides; C082290:molybdenum trioxide; D008982:Molybdenum