title: Acute localised exanthematous pustulosis (ALEP) induced by clindamycin in pregnancy.
abstract: Acute generalised exanthematous pustulosis (AGEP) or toxic pustuloderma (TP) is an uncommon though well-recognised cutaneous hypersensitivity reaction that is usually drug-induced. It presents with a triad of scattered sterile pustules, fever and malaise. Acute localised exanthematous pustulosis (ALEP) is a rare and unusual variant of AGEP. We describe a case of ALEP triggered by oral clindamycin that occurred during pregnancy.
authors.affiliation: Department of Dermatology, St. George's Healthcare NHS Trust, London, UK.
authors.forename: Ryan
authors.initials: R
authors.lastname: De Cruz
authors.affiliation: Department of Dermatology, St. George's Healthcare NHS Trust, London, UK.
authors.forename: John
authors.initials: J
authors.lastname: Ferguson
authors.affiliation: Department of Dermatology, St. George's Healthcare NHS Trust, London, UK.
authors.forename: Jamie S
authors.initials: JS
authors.lastname: Wee
authors.affiliation: Department of Dermatology, St. George's Healthcare NHS Trust, London, UK.
authors.forename: Victoria
authors.initials: V
authors.lastname: Akhras
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000175:diagnosis / Q000209:etiology*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002981:Clindamycin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin
keywords: acute generalised exanthematous pustulosis; acute localised exanthematous pustulosis; clindamycin; drug reaction; fixed drug eruption; pregnancy