title: Diagnostic and therapeutic guidelines for gastro-entero-pancreatic neuroendocrine neoplasms (recommended by the Polish Network of Neuroendocrine Tumours).
abstract: An increased interest in gastro-entero-pancreatic neuroendocrine neoplasms (GEP NENs) has recently been observed. These are rare neoplasms and their detection in recent years has improved. Over 50% of GEP NENs are carcinoids, and they are usually found incidentally during surgery in the small intestine and appendix and at diagnosis in distant metastases, mainly to the liver. There is a need for co-operation between specialists in various disciplines of medicine in order to work out the diagnostic and therapeutic guidelines. In this publication, we present general recommendations of the Polish Network of Neuroendocrine Tumours for the management of patients with GEP NENs, developed at the Consensus Conference which took place in Kamień Śląski in April 2013. Members of the guidelines working groups were assigned sections of the 2008 guidance to update. In the subsequent parts of this publication, we present the rules of diagnostic and therapeutic management of: - neuroendocrine neoplasms of the stomach and duodenum (including gastrinoma); - pancreatic neuroendocrine neoplasms; - neuroendocrine neoplasms of the small intestine and the appendix; - colorectal neuroendocrine neoplasms. The proposed recommendations by Polish and foreign experts representing different fields of medicine (endocrinology, gastroenterology, surgery, oncology, nuclear medicine and pathology) will be helpful in the diagnosis and treatment of GEP NENs patients.
authors.affiliation: Division of Endocrinology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland. endoklin@sum.edu.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Kos-Kudła
authors.forename: Jolanta
authors.initials: J
authors.lastname: Blicharz-Dorniak
authors.forename: Daria
authors.initials: D
authors.lastname: Handkiewicz-Junak
authors.forename: Barbara
authors.initials: B
authors.lastname: Jarząb
authors.forename: Michał
authors.initials: M
authors.lastname: Jarząb
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kunikowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kuśnierz
authors.forename: Robert
authors.initials: R
authors.lastname: Król
authors.forename: Leszek
authors.initials: L
authors.lastname: Królicki
authors.forename: Maciej
authors.initials: M
authors.lastname: Krzakowski
authors.forename: Anna
authors.initials: A
authors.lastname: Nasierowska-Guttmejer
authors.forename: Ewa
authors.initials: E
authors.lastname: Nowakowska-Duława
authors.forename: Waldemar
authors.initials: W
authors.lastname: Patkowski
authors.forename: Andrzej W
authors.initials: AW
authors.lastname: Szawłowski
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D032921:Consensus; D004704:Endocrinology / Q000592:standards; D016099:Endoscopy, Gastrointestinal / Q000379:methods; D005770:Gastrointestinal Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000628:therapy; D008495:Medical Oncology / Q000592:standards; D009367:Neoplasm Staging; D018358:Neuroendocrine Tumors / Q000145:classification / Q000175:diagnosis* / Q000628:therapy*; D011044:Poland; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'; D011785:Quality Assurance, Health Care / Q000592:standards*; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000628:therapy