title: The associations of uric acid, cardiovascular and all-cause mortality in peritoneal dialysis patients.
abstract: OBJECTIVE
  To investigate whether uric acid (UA) is an independent predictor of cardiovascular (CV) and all-cause mortality in peritoneal dialysis (PD) patients after controlling for recognized CV risk factors.
  
  
  METHODS
  A total of 2264 patients on chronic PD were collected from seven centers affiliated with the Socioeconomic Status on the Outcome of Peritoneal Dialysis (SSOP) Study. All demographic and laboratory data were recorded at baseline. Multivariate Cox regression was used to calculate the hazard ratio (HR) of CV and all-cause mortality with adjustments for recognized traditional and uremia-related CV factors.
  
  
  RESULTS
  There were no significant differences in baseline characteristics between patients with (n = 2193) and without (n = 71) UA measured. Each 1 mg/dL of increase in UA was associated with higher all-cause mortality with 1.05(1.00∼1.10) of HR and higher CV mortality with 1.12 (1.05∼1.20) of HR after adjusting for age, gender and center size. The highest gender-specific tertile of UA predicted higher all-cause mortality with 1.23(1.00∼1.52) of HR and higher CV mortality with 1.69 (1.21∼2.38) of HR after adjusting for age, gender and center size. The predictive value of UA was stronger in patients younger than 65 years without CV disease or diabetes at baseline. The prognostic value of UA as both continuous and categorical variable weakened or disappeared after further adjusted for uremia-related and traditional CV risk factors.
  
  
  CONCLUSIONS
  The prognostic value of UA in CV and all-cause mortality was weak in PD patients generally, which was confounded by uremia-related and traditional CV risk factors.
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health; Key Laboratory of Renal Disease, Ministry of Education; Beijing, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.affiliation: Department of Nephrology, Peking University Third Hospital, Beijing, China.
authors.forename: Qing-Feng
authors.initials: QF
authors.lastname: Han
authors.affiliation: Department of Nephrology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Tong-Ying
authors.initials: TY
authors.lastname: Zhu
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Harbin Medical University, Heilongjiang, China.
authors.forename: Ye-Ping
authors.initials: YP
authors.lastname: Ren
authors.affiliation: Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Chen
authors.affiliation: Department of Nephrology, Peking University People's Hospital, Beijing, China.
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Zhao
authors.affiliation: Department of Nephrology, General Hospital of Ningxia Medical University, Ningxia, China.
authors.forename: Meng-Hua
authors.initials: MH
authors.lastname: Chen
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health; Key Laboratory of Renal Disease, Ministry of Education; Beijing, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Nephrology, Peking University Third Hospital, Beijing, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Nephrology, Huashan Hospital of Fudan University, Shanghai, China.
authors.forename: Chuan-Ming
authors.initials: CM
authors.lastname: Hao
authors.affiliation: Department of Nephrology, Second Affiliated Hospital of Harbin Medical University, Heilongjiang, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Zhang
authors.affiliation: Department of Nephrology, Peking University People's Hospital, Beijing, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Nephrology, General Hospital of Ningxia Medical University, Ningxia, China.
authors.forename: Na
authors.initials: N
authors.lastname: Tian
authors.affiliation: Renal Division, Department of Medicine, Peking University First Hospital; Institute of Nephrology, Peking University; Key Laboratory of Renal Disease, Ministry of Health; Key Laboratory of Renal Disease, Ministry of Education; Beijing, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Wang
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000401:mortality*; D011379:Prognosis; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid