title: Association between estrogen receptor alpha PvuII polymorphism and prostate cancer risk.
abstract: Accumulating evidence has suggested that estrogen receptor alpha (ER-α) PvuII polymorphism might be involved in the development of prostate cancer (PCa). However, the results have been inconsistent. We therefore performed a meta-analysis to clarify the associations between ER-α PvuII polymorphism and PCa. A comprehensive search was conducted to identify all case-control studies of ER-α PvuII polymorphism and PCa risk. We used odds ratios (ORs) to assess the strength of the association and 95% confidence intervals (CIs) to give a sense of the precision of the estimate. A total of 14 studies were found to be eligible for meta-analyses of PvuII variant. Results from this study showed that ER-α PvuII polymorphism were significantly associated with PCa risk under all genetic models in overall population (homogeneous codominant model, OR = 1.57, 95% CI = 1.11-2.21, P = 0.010; heterogeneous codominant model, OR = 1.37, 95% CI = 1.06-1.77, P = 0.02; recessive model, OR = 1.27, 95% CI = 1.02-1.57, P = 0.03; dominant model, OR = 1.40, 95% CI = 1.09-1.79, P = 0.009; and allelic model, OR = 1.25, 95% CI = 1.06-1.48, P = 0.010). Further sensitivity analysis confirmed the significant association. In subgroup analyses stratified by PCa type, there was a significant association between PvuII polymorphism and sporadic PCa risk under both Caucasians and Asians. The meta-analysis indicated elected PvuII polymorphism of ER-α was a risk factor for PCa development.
authors.affiliation: Department of Radiology, Second Affiliated Hospital of Tianjin Medical University, 23 Pingjiang Road, Hexi District, Tianjin, 300211, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Xuening
authors.initials: X
authors.lastname: Zhang
authors.forename: Qinglai
authors.initials: Q
authors.lastname: Xia
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Wenjing
authors.initials: W
authors.lastname: Hou
mesh_terms: D015257:DNA-Cytosine Methylases; D047628:Estrogen Receptor alpha / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D017594:Publication Bias; D012306:Risk
chemical_list: C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; C047084:DNA modification methylase PvuII; D015257:DNA-Cytosine Methylases