title: Antifungal Metabolites Produced by Chaetomium globosum No.04, an Endophytic Fungus Isolated from Ginkgo biloba.
abstract: The fungal endophyte Chaetomium globosum No.04 was isolated from the medicinal plant Ginkgo biloba. The crude extract of the fungus fermentation were active in the agar-diffusion tests against the phytopathogenic fungi Rhizopus stolonifer and Coniothyrium diplodiella. Further bioassay-guided chemical investigation led to the isolation and purification of six alkaloids and three non-targeted compounds from 50 L fermentation of this endophytic fungus and their structures were elucidated as chaetoglobosin A, C, D, E, G, R (1-6), ergosterol, allantoin and uracil, by means of spectroscopic analysis. Compounds 1-6 showed significant growth inhibitory activity against R. stolonifer and C. diplodiella at a concentration of 20 μg/disc. We present here, for the first time, the potent antifungal activity of chaetoglobosins from endophytic fungi against two important phytopathogenic fungi R. stolonifer and C. diplodiella.
authors.affiliation: College of Plant Sciences, Changchun, Jilin China.
authors.forename: Guizhen
authors.initials: G
authors.lastname: Zhang
authors.affiliation: College of Plant Sciences, Changchun, Jilin China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: College of Plant Sciences, Changchun, Jilin China.
authors.forename: Jianchun
authors.initials: J
authors.lastname: Qin
authors.affiliation: College of Plant Sciences, Changchun, Jilin China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Qu
authors.affiliation: College of Plant Sciences, Changchun, Jilin China.
authors.forename: Jinliang
authors.initials: J
authors.lastname: Liu
authors.affiliation: College of Plant Sciences, Changchun, Jilin China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.affiliation: College of Plant Sciences, Changchun, Jilin China.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Pan
keywords: Antifungal activity; Chaetoglobosins; Chaetomium globosum