title: Prognostic quality of the Union Internationale Contre le Cancer/American Joint Committee on Cancer TNM classification, 7th edition, for cancer of the maxillary sinus.
abstract: BACKGROUND
  Carcinomas of the maxillary sinus are classified according to the Union Internationale Contre le Cancer (UICC)/American Joint Committee on Cancer (AJCC) TNM classification. The purpose of this study was to assess the prognostic significance of the UICC/AJCC TNM classification seventh edition, which was introduced in 2010.
  
  
  METHODS
  One hundred thirteen patients with malignant tumors of the maxillary sinus were included in this study. The prognostic impact of the TNM classification and the UICC/AJCC seventh edition's stage grouping were analyzed in univariate and multivariate analysis.
  
  
  RESULTS
  The UICC/AJCC stage grouping, the T classification, and the N classification had a significant impact on overall survival (OS) in univariate analysis (p < .05). No significant differences were observed between the groups T4a and T4b (p = .109). In multivariate analysis, the UICC/AJCC stage grouping (p = .031), the N classification (p = .014), and age (p < .001) had a significant impact on OS.
  
  
  CONCLUSIONS
  Although UICC/AJCC stage grouping and the N classification provided a significant prediction of OS in univariate and multivariate analysis, T classification only influenced OS in univariate analysis.
authors.affiliation: Department for Oral and Cranio-Maxillo and Facial Plastic Surgery, University of Cologne, Cologne, Germany; Center of Integrated Oncology (CIO), Cologne-Bonn, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Kreppel
authors.forename: Nilofar-Natalie
authors.initials: NN
authors.lastname: Amir Manawi
authors.forename: Martin
authors.initials: M
authors.lastname: Scheer
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Nickenig
authors.forename: Daniel
authors.initials: D
authors.lastname: Rothamel
authors.forename: Timo
authors.initials: T
authors.lastname: Dreiseidler
authors.forename: Uta
authors.initials: U
authors.lastname: Drebber
authors.forename: Max
authors.initials: M
authors.lastname: Zinser
authors.forename: Joachim E
authors.initials: JE
authors.lastname: Zöller
authors.forename: Orlando
authors.initials: O
authors.lastname: Guntinas-Lichius
authors.forename: Simon Florian
authors.initials: SF
authors.lastname: Preuss
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D002423:Cause of Death; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging / Q000145:classification*; D011379:Prognosis; D016016:Proportional Hazards Models; D011786:Quality Control; D012189:Retrospective Studies; D012737:Sex Factors; D012955:Societies, Medical; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States
keywords: Union for International Cancer Control (UICC)/American Joint Committee on Cancer (AJCC); maxillary sinus cancer; multivariate analysis; prognosis; stage grouping