title: Simple, chemoselective hydrogenation with thermodynamic stereocontrol.
abstract: Few methods permit the hydrogenation of alkenes to a thermodynamically favored configuration when steric effects dictate the alternative trajectory of hydrogen delivery. Dissolving metal reduction achieves this control, but with extremely low functional group tolerance. Here we demonstrate a catalytic hydrogenation of alkenes that affords the thermodynamic alkane products with remarkably broad functional group compatibility and rapid reaction rates at standard temperature and pressure.
authors.affiliation: Department of Chemistry, The Scripps Research Institute , La Jolla, California 92037, United States.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Kanny K
authors.initials: KK
authors.lastname: Wan
authors.forename: Alberto
authors.initials: A
authors.lastname: Oppedisano
authors.forename: Steven W M
authors.initials: SW
authors.lastname: Crossley
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Shenvi
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D006865:Hydrogenation; D015394:Molecular Structure; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D000473:Alkanes; D000475:Alkenes; D006859:Hydrogen