title: The multilayered complexity of ceRNA crosstalk and competition.
abstract: Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.
authors.affiliation: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Tay
authors.affiliation: 1] Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. [2] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA. [3] Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02142, USA.
authors.forename: John
authors.initials: J
authors.lastname: Rinn
authors.affiliation: Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Pandolfi
mesh_terms: D000818:Animals; D060565:Argonaute Proteins / Q000378:metabolism; D001667:Binding, Competitive; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D011544:Pseudogenes / Q000235:genetics; D012313:RNA / Q000235:genetics / Q000378:metabolism; D017393:RNA Editing; D000079962:RNA, Circular; D062085:RNA, Long Noncoding / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism
chemical_list: D060565:Argonaute Proteins; D035683:MicroRNAs; D000079962:RNA, Circular; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D012313:RNA