title: Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions.
abstract: TRAF3 is an adapter protein that serves and regulates the functions of several types of receptors, located both inside the cell and at the plasma membrane. These include members of the TNF receptor superfamily (TNFR-SF), toll-like receptors (TLR), and cytokine receptors. It has become increasingly evident that the roles and functions of TRAF3 are highly context-dependent. TRAF3 can serve distinct roles for different receptors in the same cell, and also has highly cell-type-dependent functions. This review focuses upon the current state of knowledge regarding how TRAF3 regulates the biology and effector functions of B and T lymphocytes, two major cell types of the adaptive immune response in which TRAF3 has markedly distinct roles.
authors.affiliation: Department of Microbiology, The University of Iowa, USA.
authors.forename: Zuoan
authors.initials: Z
authors.lastname: Yi
authors.affiliation: The Graduate Program in Immunology, The University of Iowa, USA.
authors.forename: Wai Wai
authors.initials: WW
authors.lastname: Lin
authors.affiliation: Department of Microbiology, The University of Iowa, USA.
authors.forename: Laura L
authors.initials: LL
authors.lastname: Stunz
authors.affiliation: Department of Microbiology, The University of Iowa, USA; The Graduate Program in Immunology, The University of Iowa, USA; Department of Internal Medicine, The University of Iowa, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address: gail-bishop@uiowa.edu.
authors.forename: Gail A
authors.initials: GA
authors.lastname: Bishop
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D018121:Receptors, Cytokine / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D048008:TNF Receptor-Associated Factor 3 / Q000235:genetics / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D016328:NF-kappa B; D011948:Receptors, Antigen, T-Cell; D018121:Receptors, Cytokine; D018124:Receptors, Tumor Necrosis Factor; D048008:TNF Receptor-Associated Factor 3; C090656:TRAF3 protein, human; D051193:Toll-Like Receptors
keywords: B lymphocyte; Lymphocyte activation; Signal transduction; T lymphocyte; TRAF