title: Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration.
abstract: Capsaicin o/w nanoemulsions with enhanced skin permeation were successfully prepared by controlling the ratios of the surfactant mixtures, oleoresin capsicum as the oil phase, and aqueous phase. Oleoresin capsicum contains 22.67 mg/g of capsaicin, which is an active and oil-soluble ingredient. Nonionic surfactants, Tween 80 and Span 80, were used to optimize the weight ratio of surfactant mixtures (85.98:14.02) by calculating the hydrophile-lipophile balance (HLB) value. The optimal processing conditions for stable nanoemulsions were investigated by using a ternary phase diagram. The mean droplet size of nanoemulsions ranged from 20 to 62 nm. Skin permeation studies were performed using a Franz diffusion cell. The permeation profiles and confocal laser scanning microscopy (CLSM) images supported that capsaicin nanoemulsion could well permeate all skin layers from the stratum corneum to the dermis. The selected nanoemulsions showed great potential as transdermal delivery carriers for enhancing the permeation of core materials.
authors.affiliation: College of Life Sciences & Biotechnology, Korea University , Anam-dong, Seongbuk-gu, Seoul 136-701, Korea.
authors.forename: Jee Hye
authors.initials: JH
authors.lastname: Kim
authors.forename: Jung A
authors.initials: JA
authors.lastname: Ko
authors.forename: Jun Tae
authors.initials: JT
authors.lastname: Kim
authors.forename: Dong Su
authors.initials: DS
authors.lastname: Cha
authors.forename: Jin Hun
authors.initials: JH
authors.lastname: Cho
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Park
authors.forename: Gye Hwa
authors.initials: GH
authors.lastname: Shin
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002211:Capsaicin / Q000737:chemistry* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry; D010539:Permeability / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry*; D012867:Skin / Q000187:drug effects*; D012869:Skin Absorption / Q000187:drug effects; D013552:Swine
chemical_list: D004655:Emulsions; D010936:Plant Extracts; C018620:oleoresins; D002211:Capsaicin
keywords: HLB value; capsaicin; confocal microscopy; nanoemulsion; skin penetration