title: Genetic contributors to otitis media: agnostic discovery approaches.
abstract: Otitis media (OM) is the most common disease in children in the United States, with about $5 billion spent each year in direct and indirect costs. OM is the number one reason for pediatric antibiotic usage and surgery, although treatment options are limited. Numerous studies have established the high heritability of OM and a genetic contribution to OM pathogenesis. Candidate gene studies have highlighted the roles of inflammation, mucin secretion, and pathogen recognition, but this approach is unable to identify novel pathways to target for treatment or screening purposes. Here, we review the current literature on agnostic approaches to discover novel genes and pathways involved in OM pathogenesis.
authors.affiliation: Center for Public Health Genomics, University of Virginia, PO Box 800717, Charlottesville, VA, 22908, USA.
authors.forename: E Kaitlynn
authors.initials: EK
authors.lastname: Allen
authors.forename: Ani
authors.initials: A
authors.lastname: Manichaikul
authors.forename: Michèle M
authors.initials: MM
authors.lastname: Sale
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D010033:Otitis Media / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents