title: Correlation of preoperative magnetic resonance imaging of peritoneal carcinomatosis and clinical outcome after peritonectomy and HIPEC after 3 years of follow-up: preliminary results.
abstract: OBJECTIVE
  In patients with peritoneal carcinomatosis, cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is an evolving approach with curative intention. Previous studies indicate a correlation between preoperative magnetic resonance imaging (MRI) and surgical findings regarding the extent of peritoneal carcinomatosis. The aim of this study was to assess retrospectively whether preoperative MRI can predict the outcome and is therefore a suitable tool for patient selection.
  
  
  METHODS
  Fifteen patients with laparoscopically proven peritoneal carcinomatosis were preoperatively examined using a 1.5-T whole-body MRI system. Results were correlated with surgical exploration. Follow-up was done by contrast-enhanced abdominal computed tomography and, if suspicious for recurring disease, laparoscopy or laparotomy. Survival time and interval to recurring disease were correlated with the preoperative peritoneal carcinomatosis index (PCI) on MRI (Spearman's rank correlation).
  
  
  RESULTS
  In five patients radical resection could not be achieved (PCI 34 ± 6.9); survival time was 78.2 ± 54.1 days. In seven patients recurring disease was found 430 ± 261.2 days after initial complete cytoreduction (PCI 11.6 ± 6.9); survival time was 765.9 ± 355 days. Two patients are still alive after 3 years. Two patients with initially complete cytoreduction are without recurring disease after 3 years (PCI 5 and 12). One patient was lost for follow-up.
  
  
  CONCLUSIONS
  Results of the preoperative MRI correlate well with the surgical PCI, postoperative resection status, and survival time. MRI might be a suitable technique for patient selection when considering peritonectomy and HIPEC. In our patients the outcome seems to correlate well with the extent of peritoneal carcinomatosis found by the preoperative MRI.
authors.affiliation: Eberhard-Karls-University Tuebingen, Department for Diagnostic and Interventional Radiology, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Klumpp
authors.affiliation: Diakonie Klinikum Stuttgart, Südwestdeutsches PET-Zentrum, Seidenstrasse 47, 70174 Stuttgart, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Aschoff
authors.affiliation: Eberhard-Karls-University Tuebingen, Department for Diagnostic and Interventional Radiology, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Schwenzer
authors.affiliation: Eberhard-Karls-University Tuebingen, Department for General, Visceral and Transplantation Surgery, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Koenigsrainer
authors.affiliation: Eberhard-Karls-University Tuebingen, Department for General, Visceral and Transplantation Surgery, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Beckert
authors.affiliation: Eberhard-Karls-University Tuebingen, Department for Diagnostic and Interventional Radiology, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.
authors.forename: C D
authors.initials: CD
authors.lastname: Claussen
authors.affiliation: Radiologiepraxis Dr Aicher, Dr Kölbel, Prof Dr Miller, Uhlandstrasse 8, 72072 Tuebingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Miller
authors.affiliation: Eberhard-Karls-University Tuebingen, Department for General, Visceral and Transplantation Surgery, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Koenigsrainer
authors.affiliation: Eberhard-Karls-University Tuebingen, Department for Diagnostic and Interventional Radiology, Hoppe-Seyler-Strasse 3, 72076 Tuebingen, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Pfannenberg
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D010537:Peritoneum / Q000601:surgery*; D049268:Positron-Emission Tomography; D016896:Treatment Outcome
chemical_list: D019788:Fluorodeoxyglucose F18