title: Vasopressin and oxytocin in CSF and plasma of patients with aneurysmal subarachnoid haemorrhage.
abstract: OBJECTIVE
  Clinicopathological studies on patients succumbing to subarachnoid haemorrhage (SAH) demonstrated hypothalamic lesions. The implication of the hypothalamic neuropeptides arginine-vasopressin (AVP) and oxytocin (OXT) has not been linked to aneurysmal SAH yet. This study investigates AVP and OXT in CSF and plasma of patients with spontaneous aneurysmal SAH and their association with outcome.
  
  
  METHODS
  CSF and plasma samples of 12 patients with aneurysmal SAH were prospectively studied for 2weeks. AVP and OXT were measured by radioimmunoassay. Outcome was assessed on Glasgow-Outcome-Scale. Twenty-nine patients without neuropsychiatric disturbances served as controls. Differences in neuropeptide concentration time courses were assessed by regression models. Group comparisons were performed by Kruskal-Wallis and correlations by Spearman tests.
  
  
  RESULTS
  Regression of CSF levels between patients with poor and good outcome revealed significantly lower levels of AVP in patients with poor outcome (p=0.012) while OXT showed a trend towards lower levels (p=0.063). In plasma, no significant differences between outcome groups were found. Group comparisons between poor outcome patients and controls revealed significant differences in CSF for AVP (p=0.001) and OXT (p=0.015). In plasma, AVP yielded significantly different results while OXT did not. No differences were found between the good outcome group and controls. Plasma and CSF concentrations showed no significant correlation.
  
  
  CONCLUSIONS
  Patients with poor outcome after aneurysmal SAH have lower AVP and OXT levels in CSF than patients with good outcome while neuropeptide levels in plasma failed to reflect differences in outcome. The data indicate hypothalamic damage as an aetiologic factor for outcome after aneurysmal SAH.
authors.affiliation: Klinik für Anaesthesiologie, Technische Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 München, Germany. Electronic address: j.martin@lrz.tum.de.
authors.forename: Jan
authors.initials: J
authors.lastname: Martin
authors.affiliation: Klinik für Anaesthesiologie, Technische Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 München, Germany.
authors.forename: Simone M
authors.initials: SM
authors.lastname: Kagerbauer
authors.affiliation: Institut für Medizinische Statistik und Epidemiologie, Technische Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 München, Germany.
authors.forename: Tibor
authors.initials: T
authors.lastname: Schuster
authors.affiliation: Klinik für Anaesthesiologie, Technische Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 München, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Blobner
authors.affiliation: Klinik für Anaesthesiologie, Technische Universität München, Klinikum rechts der Isar, Ismaninger Strasse 22, 81675 München, Germany.
authors.forename: Eberhard F
authors.initials: EF
authors.lastname: Kochs
authors.affiliation: Max-Planck-Institut für Psychiatrie, Kraepelinstrasse 2, 80804 München, Germany.
authors.forename: Rainer
authors.initials: R
authors.lastname: Landgraf
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D023261:Glasgow Outcome Scale; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010121:Oxytocin / Q000097:blood* / Q000134:cerebrospinal fluid*; D011379:Prognosis; D012044:Regression Analysis; D013345:Subarachnoid Hemorrhage / Q000378:metabolism* / Q000503:physiopathology; D014667:Vasopressins / Q000097:blood* / Q000134:cerebrospinal fluid*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014667:Vasopressins; D010121:Oxytocin
keywords: Aneurysmal; CSF; Haemorrhage; Oxytocin; Plasma; Subarachnoid; Vasopressin