title: Highly selective gem-difluoroallylation of organoborons with bromodifluoromethylated alkenes catalyzed by palladium.
abstract: A first example of Pd-catalyzed gem-difluoroallylation of organoborons using 3-bromo-3,3-difluoropropene (BDFP) in high efficiency with high α/γ-substitution regioselectivity has been developed. The reaction can also be extended to substituted BDFPs and has advantages of low catalyst loading (0.8 to 0.01 mol %), broad substrate scope, and excellent functional group compatibility, thus providing a facile route for practical application in drug discovery and development.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
authors.forename: Qiao-Qiao
authors.initials: QQ
authors.lastname: Min
authors.forename: Zengsheng
authors.initials: Z
authors.lastname: Yin
authors.forename: Zhang
authors.initials: Z
authors.lastname: Feng
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Guo
authors.forename: Xingang
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D001896:Boron Compounds / Q000737:chemistry*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D001896:Boron Compounds; D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; D010165:Palladium