title: Convenient synthesis of benzothiazoles and benzimidazoles through Brønsted acid catalyzed cyclization of 2-amino thiophenols/anilines with β-diketones.
abstract: Brønsted acid catalyzed cyclization reactions of 2-amino thiophenols/anilines with β-diketones under oxidant-, metal-, and radiation-free conditions are described. Various 2-substituted benzothiazoles/benzimidazoles are obtained in satisfactory to excellent yields. Different groups such as methyl, chloro, nitro, and methoxy linked on benzene rings were tolerated under the optimized reaction conditions.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology , Dalian 116023, China.
authors.forename: Muhammad Shareef
authors.initials: MS
authors.lastname: Mayo
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Yu
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Feng
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Ming
authors.initials: M
authors.lastname: Bao
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D001562:Benzimidazoles; D052160:Benzothiazoles; D007659:Ketones; D010636:Phenols; D013438:Sulfhydryl Compounds; C042983:thiophenol