title: Bioactive calcium sulfate/magnesium phosphate cement for bone substitute applications.
abstract: A novel calcium sulfate/magnesium phosphate cement (CSMPC) composite was prepared and studied in the present work. The physical properties including the phases, the microstructures, the setting properties and the compressive strengths of the CSMPCs were studied. The bio-performances of the CSMPCs were comprehensively evaluated using in vitro simulated body fluid (SBF) method and in vitro cell culture. The dependence of the physical and chemical properties of the CSMPC on its composition and microstructure was studied in detail. It is found that the CSMPC composites exhibited mediate setting times (6-12 min) compared to the calcium sulfate (CS) and the magnesium phosphate cement (MPC). They showed an encapsulation structure in which the unconverted hexagonal prism CSH particles were embedded in the xerogel-like MPC matrix. The phase compositions and the mechanical properties of the CSMPCs were closely related to the content of MPC and the hardening process. The CSMPCs exhibited excellent bioactivity and good biocompatibility to support the cells to attach and proliferate on the surface. The CSMPC composite has the potential to serve as bone grafts for the bone regeneration.
authors.affiliation: Department of Orthopaedics, Taizhou Hospital of Zhejiang Province, Linhai Zhejiang, 317000, China; Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China.
authors.forename: Guangyong
authors.initials: G
authors.lastname: Yang
authors.affiliation: Trauma Center, Affiliated Hospital of Hainan Medical University, Haikou, Hainan, 570206, China; Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences (CAS), Ningbo, Zhejiang, 315201, China.
authors.forename: Jianli
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.affiliation: Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China.
authors.forename: Zongyou
authors.initials: Z
authors.lastname: Pan
authors.affiliation: Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Ni
authors.affiliation: Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang, 325000, China. Electronic address: spinexu@163.com.
authors.forename: Huazi
authors.initials: H
authors.lastname: Xu
authors.affiliation: Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences (CAS), Ningbo, Zhejiang, 315201, China. Electronic address: huangqing@nimte.ac.cn.
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000268:Adhesiveness; D001843:Bone Cements / Q000138:chemical synthesis* / Q000494:pharmacology; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000494:pharmacology; D002133:Calcium Sulfate / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D006244:Hardness; D006801:Humans; D017616:Magnesium Compounds / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology*; D010710:Phosphates / Q000737:chemistry* / Q000494:pharmacology; D013718:Tensile Strength
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D017616:Magnesium Compounds; D010710:Phosphates; C030781:magnesium phosphate; D002133:Calcium Sulfate
keywords: Bioactivity; Bone substitutes; Calcium sulfate/magnesium phosphate cement (CSMPC); Cytotoxicity; Degradability