title: Factors associated with health-related quality of life in chronic leg ulceration.
abstract: BACKGROUND
  Individuals with chronic leg ulceration may have significantly impaired health-related quality of life (HRQOL) due to pain, impaired mobility, poor sleep, depression, restricted work capacity, and social isolation. The study purpose was to examine the associations among sociodemographic and clinical factors and HRQOL in a large sample of community-dwelling adults being treated for leg ulcers.
  
  
  METHODS
  Data are from the cross-sectional baseline assessment of the Canadian Bandaging Trial, a multi-center, randomized controlled trial conducted to assess time to healing with two forms of high-compression bandaging. All participants received a comprehensive, standardized clinical assessment, and completed the 12-item Short Form (SF-12) and McGill Pain Questionnaire. SF-12 data were compared to age- and sex-adjusted norms, and multivariable logistic regression was used to identify factors associated with whether individuals were below, or at/above their normative values on the physical and mental component summary (PCS, MCS).
  
  
  RESULTS
  Of 424 individuals enrolled over a 50-month period, 407 (96 %) completed the SF-12. Mean age was 65 ± 17 years, and 55 % were women. Mean PCS was 39.1 ± 9.9 with 91 (22.4 %) scoring at/above the mean value for their age and sex; equivalent values for the MCS were 51.4 ± 9.9 and 209 (51.4 %). Higher levels of pain, younger age, larger size and longer duration of ulcer, and limited mobility were associated with poorer HRQOL.
  
  
  CONCLUSIONS
  Findings confirm the considerable burden of illness associated with leg ulcers. Given the chronic and recurring nature of the condition, strategies focused on improving HRQOL and healing are needed for this vulnerable population.
authors.affiliation: Clinical Research Centre, Health Sciences Research, Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada, hopmanw@kgh.kari.net.
authors.forename: Wilma M
authors.initials: WM
authors.lastname: Hopman
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: VanDenKerkhof
authors.forename: Meg E
authors.initials: ME
authors.lastname: Carley
authors.forename: Janet L
authors.initials: JL
authors.lastname: Kuhnke
authors.forename: Margaret B
authors.initials: MB
authors.lastname: Harrison
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D002170:Canada / Q000453:epidemiology; D002908:Chronic Disease; D015897:Comorbidity; D058128:Compression Bandages; D003430:Cross-Sectional Studies; D003627:Data Interpretation, Statistical; D004487:Edema / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology / Q000628:therapy; D005260:Female; D006304:Health Status; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D016032:Randomized Controlled Trials as Topic; D012923:Social Class; D064232:Visual Analog Scale