title: A straight neutrophil path to healthy aging?
abstract: In this issue of Blood, Sapey et al. report that the human polymorphonuclear neutrophil leukocyte (or neutrophil) undergoes an age-related loss of its ability to migrate up chemotactic gradients, a functional defect that seems causally related to alterations in the polyphosphoinositide pathway.
authors.affiliation: LAVAL UNIVERSITY;
authors.forename: Paul H
authors.initials: PH
authors.lastname: Naccache
authors.forename: Julie S
authors.initials: JS
authors.lastname: Lefebvre
mesh_terms: D000375:Aging / Q000276:immunology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D006801:Humans; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors
chemical_list: D000081082:Phosphoinositide-3 Kinase Inhibitors