title: Tick repellents for human use: prevention of tick bites and tick-borne diseases.
abstract: Ticks are arthropods and the most important vectors of major human diseases after mosquitoes. Due to their impact on public health, in vitro and in vivo assays have been developed to identify molecules with repellent activities on ticks. Repellents are useful to reduce tick bite exposure and the potential transmission of pathogens; they can be used topically or in impregnated clothing. Presently, mainly synthetic molecules are commercialized as skin repellents, e.g., N,N-diethyl-meta-toluamide (DEET), IR3535, picaridin or KBR 3023, and para-menthanediol. Permethrin is largely used for fabric impregnation. Intensive research has been conducted to identify new molecules with repellent activity and more recently, plant-derived molecules, as an alternative to synthetic molecules.
authors.affiliation: 1 Cire OI , St. Denis Cedex 9, Réunion, France .
authors.forename: Frédéric
authors.initials: F
authors.lastname: Pages
authors.forename: Hans
authors.initials: H
authors.lastname: Dautel
authors.forename: Gérard
authors.initials: G
authors.lastname: Duvallet
authors.forename: Olaf
authors.initials: O
authors.lastname: Kahl
authors.forename: Ludovic
authors.initials: L
authors.lastname: de Gentile
authors.forename: Nathalie
authors.initials: N
authors.lastname: Boulanger
mesh_terms: D056810:Acaricides / Q000494:pharmacology*; D000818:Animals; D001179:Arthropod Vectors; D001681:Biological Assay / Q000379:methods; D003671:DEET; D006801:Humans; D009822:Oils, Volatile; D026023:Permethrin; D010880:Piperidines; D010936:Plant Extracts; D011422:Propionates; D011481:Protective Clothing; D064927:Tick Bites / Q000517:prevention & control*; D017282:Tick-Borne Diseases / Q000517:prevention & control*; D013987:Ticks / Q000187:drug effects* / Q000502:physiology
chemical_list: D056810:Acaricides; D009822:Oils, Volatile; D010880:Piperidines; D010936:Plant Extracts; D011422:Propionates; C508356:citriodiol; D003671:DEET; D026023:Permethrin; C462400:ethyl-3-(N-n-butyl-N-acetyl)aminopropionate; C483506:picaridin