title: Post-study caffeine administration enhances memory consolidation in humans.
abstract: It is currently not known whether caffeine has an enhancing effect on long-term memory in humans. We used post-study caffeine administration to test its effect on memory consolidation using a behavioral discrimination task. Caffeine enhanced performance 24 h after administration according to an inverted U-shaped dose-response curve; this effect was specific to consolidation and not retrieval. We conclude that caffeine enhanced consolidation of long-term memories in humans.
authors.affiliation: Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Borota
authors.affiliation: Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Murray
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Gizem
authors.initials: G
authors.lastname: Keceli
authors.affiliation: Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Allen
authors.initials: A
authors.lastname: Chang
authors.affiliation: Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Watabe
authors.affiliation: Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Ly
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.
authors.forename: John P
authors.initials: JP
authors.lastname: Toscano
authors.affiliation: 1] Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, Maryland, USA. [2] Department of Neurobiology and Behavior, University of California, Irvine, California, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Yassa
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D057567:Memory, Long-Term / Q000187:drug effects*; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000187:drug effects; D012463:Saliva / Q000378:metabolism; D013997:Time Factors; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine