title: Association of Kallikrein gene polymorphisms with sporadic intracranial aneurysms in the Chinese population.
abstract: OBJECTIVE
  Variants of Kallikreins have been shown to be risk factors for intracranial aneurysm (IA) in a Finnish population. In the present study, the authors investigated the correlation between polymorphisms in the Kallikrein gene cluster and IAs in the Chinese population.
  
  
  METHODS
  The association of Kallikrein variants (rs1722561 and rs1701946) with sporadic IAs was tested in 308 cases and 443 controls. The differences in allelic frequencies between patients and the control group were evaluated with the chi-square test.
  
  
  RESULTS
  The C allele of rs1722561 showed a significant reduction in the risk of sporadic IA (OR 0.71, 95% CI 0.53-0.95; p = 0.023). However, no association of the variant rs1701946 with sporadic IA was found (OR 0.78, 95% CI 0.57-1.06; p = 0.115).
  
  
  CONCLUSIONS
  The variant rs1722561 of Kallikreins might reduce the risk of sporadic IAs among individuals of Chinese Han ethnicity. This study confirms the association between Kallikreins and IAs.
authors.affiliation: Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing;
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Suo
authors.forename: Yahui
authors.initials: Y
authors.lastname: Lin
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Weihua
authors.initials: W
authors.lastname: Song
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Yinhui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Channa
authors.initials: C
authors.lastname: Zhang
authors.forename: Yufang
authors.initials: Y
authors.lastname: Zhu
authors.forename: Qi
authors.initials: Q
authors.lastname: Pang
authors.forename: Rutai
authors.initials: R
authors.lastname: Hui
authors.forename: Jingzhou
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D002532:Intracranial Aneurysm / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D007610:Kallikreins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
chemical_list: D007610:Kallikreins
keywords: DSA = digital subtraction angiography; ECM = extracellular matrix; IA = intracranial aneurysm; Kallikreins; LDR = ligase detection reaction; MRA = MR angiography; PCR = polymerase chain reaction; SAH = subarachnoid hemorrhage; SNP = single nucleotide polymorphism; intracranial aneurysm; variant; vascular disorders