title: Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations.
abstract: Multiscale simulations are essential in the biomedical domain to accurately model human physiology. We present a modular approach for designing, constructing and executing multiscale simulations on a wide range of resources, from laptops to petascale supercomputers, including combinations of these. Our work features two multiscale applications, in-stent restenosis and cerebrovascular bloodflow, which combine multiple existing single-scale applications to create a multiscale simulation. These applications can be efficiently coupled, deployed and executed on computers up to the largest (peta) scale, incurring a coupling overhead of 1-10% of the total execution time.
authors.affiliation: Centre for Computational Science, University College London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Groen
authors.affiliation: Section Computational Science, University of Amsterdam, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Borgdorff
authors.affiliation: Section Computational Science, University of Amsterdam, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Bona-Casas
authors.affiliation: Centre for Computational Science, University College London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Hetherington
authors.affiliation: Centre for Computational Science, University College London, UK.
authors.forename: R W
authors.initials: RW
authors.lastname: Nash
authors.affiliation: Centre for Computational Science, University College London, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Zasada
authors.affiliation: Leibniz-Rechenzentrum, Garching, Germany.
authors.forename: I
authors.initials: I
authors.lastname: Saverchenko
authors.affiliation: Poznan Supercomputing and Networking Center, Poznan, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Mamonski
authors.affiliation: Poznan Supercomputing and Networking Center, Poznan, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Kurowski
authors.affiliation: Centre for Computational Science, University College London, UK.
authors.forename: M O
authors.initials: MO
authors.lastname: Bernabeu
authors.affiliation: Section Computational Science, University of Amsterdam, The Netherlands.
authors.forename: A G
authors.initials: AG
authors.lastname: Hoekstra
authors.affiliation: Centre for Computational Science, University College London, UK.
authors.forename: P V
authors.initials: PV
authors.lastname: Coveney
keywords: blood flow; cerebrovascular bloodflow; distributed computing; high performance computing; in-stent restenosis; multiscale modelling