title: Synthesis of water-soluble Cu/PAA composite flowers and their antibacterial activities.
abstract: Water-soluble copper/polyacrylic acid (Cu/PAA) composites were synthesized by a facile solution-phase reduction route. The Cu/PAA composites presented flower-like architecture, consisting of several intercrossing sheets, and reaction conditions had an important effect on their morphologies. Their antibacterial activity towards the bacterial strains such as Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) were evaluated by the minimum inhibitory concentration (MIC), the minimum bactericidal concentration (MBC), cup diffusion method and optical density (OD600). Results indicated that Cu/PAA flower is selective in its antibacterial action. It displays more effective antibacterial activity against B. subtilis than other three stains, and better bactericidal activity against S. aureus, E. coli and P. aeruginosa than B. subtilis. There is no bactericidal ability against B. subtilis in the tested concentration range, which indicates that B. subtilis may be a copper-tolerant bacterium.
authors.affiliation: Institute of Immunology, Henan University, Kaifeng 475004, PR China; Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, PR China.
authors.forename: Binjie
authors.initials: B
authors.lastname: Li
authors.affiliation: Institute of Immunology, Henan University, Kaifeng 475004, PR China; Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, PR China.
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, PR China. Electronic address: zhaoyb902@henu.edu.cn.
authors.forename: Yanbao
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D018407:Bacterial Physiological Phenomena / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003300:Copper; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D008968:Molecular Conformation; D050997:Nanomedicine; D010316:Particle Size; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D014867:Water; C006903:carbopol 940; D003300:Copper
keywords: Antibacterial activity; Cu/PAA flower; Synthesis; Water-soluble