title: Effects of the regulation of follistatin mRNA expression by IGF-1 in duck (Anas platyrhynchos) skeletal muscle.
abstract: The IGF-1 and TGF-β pathways have been shown to be involved in regulating muscle development. Many mediators that are associated with the regulation of muscle development have been found to participate in the cross-talk between these two pathways. To research the relationships between IGF-1 and the follistatin-mediated TGF-β pathways in duck skeletal muscle development, a series of studies were conducted. The results showed that follistatin had similar expression patterns to IGF-1 during duck embryonic muscle development. The in ovo feeding of IGF-1 to duck eggs was shown to increase follistatin expression in the duck skeletal muscle. Thus, IGF-1 may induce the mRNA expression of follistatin. These results suggest that follistatin may be a key regulator of multiple signaling cascades responding to the cross-talk between the IGF-1 and TGF-β pathways.
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China.
authors.forename: Hehe
authors.initials: H
authors.lastname: Liu
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China.
authors.forename: Xinxin
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Sun
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China.
authors.forename: Haohan
authors.initials: H
authors.lastname: Wang
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China.
authors.forename: Rongping
authors.initials: R
authors.lastname: Zhang
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China.
authors.forename: Chao
authors.initials: C
authors.lastname: Yang
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China. Electronic address: wjw2886166@163.com.
authors.forename: Jiwen
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China.
authors.forename: Hua
authors.initials: H
authors.lastname: He
authors.affiliation: Institute of Animal Breeding and Genetics, Sichuan Agricultural University, Ya'an, Sichuan 625014, PR China.
authors.forename: Christopher
authors.initials: C
authors.lastname: Krumm
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D004372:Ducks / Q000196:embryology* / Q000235:genetics; D005260:Female; D038681:Follistatin / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D024510:Muscle Development / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000166:cytology* / Q000187:drug effects; D032446:Myoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D038681:Follistatin; D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I
keywords: Duck; Follistatin; IGF-1; Myoblast; Pathway; TGF-β