title: Familial history and recurrence of febrile seizures; a systematic review and meta-analysis.
abstract: OBJECTIVE
  Febrile seizure (FS) as the most common form of seizures in childhood, affects 2-5% of all children across the world. The present study reviews available reports on FS recurrence frequency and evaluates its associated risk factors in Iran.
  
  
  METHODS
  WE SEARCHED THE PERSIAN DATABASE SUCH AS: SID, MagIran, Medlip, Irandoc, Iranmedex as well as English databases PubMed, ISI, and Scopus. Random effects models were used to calculate 95% confidence intervals. Meta regression was introduced to explore the heterogeneity between studies.
  
  
  RESULTS
  The overall FS recurrence rate was 20.9% [95% confidence interval (CI): 12.3-29.5%]. The frequency of FS simple and complex types was 69.3% (95% CI: 59.5-79.0) and 25.3% (95% CI: 19.6-31.0), respectively. A positive familial history of 28.8% (95% CI: 19.3-38.4%) was observed for childhood FS including 36.2% (95% CI: 27.3-39.6%) for the simple and 29.4% (95% CI: 23.1-33.5%) for the complex type. The heterogeneity of recurrent FS was significantly affected by sample size (P=0.026).
  
  
  CONCLUSIONS
  Almost one-third of FS children had a positive familial history. The increased risk of recurrence in patients with symptomatic seizures needs to be fully considered by parents, physicians, nurses and health policy makers.
authors.affiliation: Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran ; Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Veisani
authors.affiliation: Department of Clinical Epidemiology, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Delpisheh
authors.affiliation: Psychological Injuries Research Center, Ilam University of Medical Sciences, Ilam, Iran.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Sayehmiri
keywords: Febrile seizure; Iran; Meta-Analysis; Positive familial History; Recurrence; Systematic review