title: The role and therapeutic implications of RING-finger E3 ubiquitin ligases in hepatocellular carcinoma.
abstract: Increasing evidence indicates that deregulation of RING-finger ubiquitin-protein ligases (E3s) involves in the development of hepatocellular carcinoma (HCC). These RING-finger E3s serve as oncoproteins or tumor suppressors in HCC under specific conditions. In this review, we summarize current knowledge about abnormal RING-finger E3s and their clinical significance in the development of HCC, and discuss parts of critical substrates for these RING-finger E3s in detail. Furthermore, in light of success of Bortezomib in treating hematological malignancies, we describe the preclinical and clinical studies of therapeutic approaches targeting aberrant RING-finger E3s in HCC.
authors.affiliation: Department of Gastroenterology, Zhongshan Hospital of Fudan University, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yin
authors.forename: Ji-Min
authors.initials: JM
authors.lastname: Zhu
authors.forename: Xi-Zhong
authors.initials: XZ
authors.lastname: Shen
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D058990:Molecular Targeted Therapy; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects*; D054829:RING Finger Domains; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex
keywords: RING-finger E3 ubiquitin ligase; hepatocellular carcinoma; therapeutic target