title: The one year exercise and lifestyle intervention program KLAKS: Effects on anthropometric parameters, cardiometabolic risk factors and glycemic control in childhood obesity.
abstract: OBJECTIVE
  Regular physical exercise within structured lifestyle programs may improve weight status and minimize metabolic risk factors in childhood obesity. The aim of this study was to evaluate the effect of the one-year combined physical exercise/lifestyle program KLAKS on anthropometric and metabolic parameters and glycemic control in childhood obesity.
  
  
  METHODS
  142 overweight/obese (BMI>90th percentile) candidates (7-18years) were enrolled, 115 participants completed the program. Anthropometrics and biochemical parameters were obtained at beginning and completion. An oral glucose tolerance test (OGTT) was performed in a subgroup of participants. Course of glucose and insulin levels within OGTT was correlated with several parameters and is reported here for those who completed the program.
  
  
  RESULTS
  The mean standard deviation scores (SDS) decreased significantly for BMI, waist circumference, waist-to-height ratio (WHtR) and percentage body fat (all p≤0.01). Improved metabolic risk markers included mean glucose levels within an OGTT at follow-up compared to baseline (p<0.0001) and HbA1c (p=0.05) as well as indications of improvement for gamma-glutamyl-transferase and free fatty acids.
  
  
  CONCLUSIONS
  The one-year combined exercise/lifestyle program KLAKS significantly improves markers of obesity and glycemic control. Impaired cardiometabolic risk markers, even subclinical, are also favorably influenced by program participation.
authors.affiliation: Leipzig University Medical Center, IFB AdiposityDiseases, Philipp-Rosenthal-Str. 27, 04103 Leipzig, Germany. Electronic address: susann.blueher@medizin.uni-leipzig.de.
authors.forename: Susann
authors.initials: S
authors.lastname: Blüher
authors.affiliation: Leipzig University Medical Center, IFB AdiposityDiseases, Philipp-Rosenthal-Str. 27, 04103 Leipzig, Germany; Center for Clinical Studies, University of Leipzig, Härtelstrasse 16 - 18, 04107 Leipzig, Germany.
authors.forename: David
authors.initials: D
authors.lastname: Petroff
authors.affiliation: KLAKS e.V., Lessingstrasse 2, 04109 Leipzig, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Wagner
authors.affiliation: KLAKS e.V., Lessingstrasse 2, 04109 Leipzig, Germany.
authors.forename: Katja
authors.initials: K
authors.lastname: Warich
authors.affiliation: CrescNet gGmbH, University of Leipzig, Philipp-Rosenthal-Str. 27b, 04103 Leipzig, Germany.
authors.forename: Ruth
authors.initials: R
authors.lastname: Gausche
authors.affiliation: MVZ Labor Dr. Reising-Ackermann & Colleagues, Strümpellstraße 40, 04289 Leipzig, 04289, Leipzig, Germany.
authors.forename: Thorsten
authors.initials: T
authors.lastname: Klemm
authors.affiliation: Gesundheitssportverein Leipzig e.V., Lessingstrasse 2, 04109 Leipzig, Germany.
authors.forename: Mario
authors.initials: M
authors.lastname: Wagner
authors.affiliation: CrescNet gGmbH, University of Leipzig, Philipp-Rosenthal-Str. 27b, 04103 Leipzig, Germany; Pediatric Medical Center, Johannisplatz 1, 04103 Leipzig, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Keller
mesh_terms: D000293:Adolescent; D000886:Anthropometry / Q000379:methods; D001786:Blood Glucose / Q000502:physiology*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D002648:Child; D015444:Exercise / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006442:Glycated Hemoglobin / Q000378:metabolism; D038321:Glycemic Index / Q000502:physiology*; D006801:Humans; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D050177:Overweight / Q000097:blood / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D012307:Risk Factors; D055105:Waist Circumference / Q000502:physiology; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006442:Glycated Hemoglobin; D005723:gamma-Glutamyltransferase; C517652:hemoglobin A1c protein, human
keywords: Childhood obesity; KLAKS program; Metabolic syndrome; Obesity therapy; Oral glucose tolerance test