title: Relationship between adiponectin and fertility in the female pig.
abstract: Adiponectin isoforms may mediate different aspects of the pleiotropic function of the protein, including the reproductive process. We examined the pattern of circulating adiponectin and adiponectin system expression in fat and ovarian tissues of hyperfertile and subfertile sows. We demonstrated the presence of five different isoforms of adiponectin (90, 158, 180, 250 and >250kDa) in the circulation and identified a subgroup of subfertile females that displayed reduced abundance of all adiponectin isoforms as well as a lack of the 250-kDa adiponectin isoform in both serum and follicular fluid. Subfertility in these animals was associated with fewer large follicles and corpora lutea in the ovaries, as well as lower concentrations of 17β-oestradiol in the follicular fluid of large follicles. In addition, subfertile females showed higher adiponectin mRNA in fat tissue and altered mRNA and protein expression of adiponectin and its receptors in the ovary. Changes in the abundance and pattern of circulating adiponectin isoforms have been associated with reproductive disorders in animals and humans, including polycystic ovarian syndrome (PCOS). Our findings suggest that the adiponectin system may play an important role in controlling ovarian function and influencing porcine fertility.
authors.affiliation: Centre de recherche en reproduction animale, Faculté de médecine vétérinaire, Université de Montréal, CP 5000, St-Hyacinthe, Québec J2S 7C6, Canada.
authors.forename: Danila B
authors.initials: DB
authors.lastname: Campos
authors.affiliation: Department of Animal Science, McGill University, St-Anne de-Bellevue, Québec H9X 3V9, Canada.
authors.forename: Marcelo
authors.initials: M
authors.lastname: Albornoz
authors.affiliation: Departamento de Cirurgia, Setor de Anatomia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo - SP, 05508-270, Brasil.
authors.forename: Paula C
authors.initials: PC
authors.lastname: Papa
authors.affiliation: Dairy and Swine Research and Development Center, Agriculture and Agri-Food Canada, Lennoxville, Québec, J1M 1Z3, Canada.
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Palin
authors.affiliation: Department of Animal Science, McGill University, St-Anne de-Bellevue, Québec H9X 3V9, Canada.
authors.forename: Vilceu
authors.initials: V
authors.lastname: Bordignon
authors.affiliation: Centre de recherche en reproduction animale, Faculté de médecine vétérinaire, Université de Montréal, CP 5000, St-Hyacinthe, Québec J2S 7C6, Canada.
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Murphy
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D003338:Corpus Luteum / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000502:physiology*; D007247:Infertility, Female / Q000097:blood / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D054419:Receptors, Adiponectin / Q000378:metabolism*; D034421:Sus scrofa; D013552:Swine
chemical_list: D052242:Adiponectin; D020033:Protein Isoforms; D054419:Receptors, Adiponectin