title: Signaling unmasked: Autophagy and catalase promote programmed cell death.
abstract: Autophagy contributes to the removal of harmful cellular refuse, whereas catalase plays an important protective role by detoxifying reactive oxygen species. We recently found that autophagy and catalase are also required for promoting programmed cell death induced during plant immune responses. Here we discuss the difficulties in identifying cell death effectors, which are also required to maintain cellular homeostasis, and how their prodeath roles were unmasked using an unbiased forward genetics approach.
authors.affiliation: Department of Biology; University of Copenhagen; Copenhagen, Denmark.
authors.forename: Morten
authors.initials: M
authors.lastname: Petersen
authors.affiliation: Department of Plant Biology and Forest Genetics; Swedish University of Agricultural Sciences (SLU) and Linnean Center for Plant Biology; Uppsala BioCenter; Uppsala, Sweden.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hofius
authors.affiliation: Department of Molecular Biology and Genetics; Aarhus University; Aarhus, Denmark.
authors.forename: Stig Uggerhøj
authors.initials: SU
authors.lastname: Andersen
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D001343:Autophagy / Q000502:physiology*; D002374:Catalase / Q000378:metabolism*; D010944:Plants / Q000201:enzymology; D017382:Reactive Oxygen Species; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species; D002374:Catalase
keywords: autophagy; catalase; cell death; plant defense; plant-microbe interactions