title: Visfatin concentrations in children with leukemia before and after stem cell transplantation.
abstract: Visfatin (VF) is an adipocytokine that performs many functions, including enhancing cell proliferation and biosynthesis of nicotinamide mononucleotides and dinucleotides. It also seems to be involved in the development of glucose metabolism disturbances. The goal of the study was the determination of VF concentrations in children with leukemia who are treated with stem cell transplantation. VF concentrations were measured in plasma before and after oral glucose tolerance test (OGTT; 60 and 120 minutes) in 22 children with leukemia treated with hematopoietic stem cell transplantation (HSCT) and healthy control subjects (n = 24). The HSCT group was studied twice: before HSCT (22 children) and approximately 6 months after HSCT (12 of 22 children). After fasting, concentrations of glucose, insulin, triglycerides, total cholesterol, high-density lipoprotein, and high-sensitivity C-reactive protein (hsCRP) were determined. Significantly lower (p < 0.05) median values of VF concentrations at all time points in the OGTT were found in pre- HSCT children compared with control subjects. The median VF concentration was significantly higher after HSCT compared with before HSCT. The decrease in VF in leukemic children in complete remission may be caused by myelosuppression and immunosuppression after prolong chemotherapy and is beneficial because of the decrease in its antiapoptotic activity. VF can serve as an additional biochemical marker for remission in patients with leukemia. Normalization of plasma VF concentration after HSCT might be caused by a process of immune reconstitution and prolonged inflammation (e.g., infections, graft-versus-host disease), injury to organs (e.g., lungs, gut, liver), and endocrinology deficiencies.
authors.affiliation: Department of Immunology, Chair of Clinical Immunology and Transplantation, Jagiellonian University Medical College, Krakow, Poland; Transplantation Centre, University Children's Hospital, Krakow, Poland. Electronic address: szymon.skoczen@uj.edu.pl.
authors.forename: Szymon
authors.initials: S
authors.lastname: Skoczen
authors.affiliation: Department of Clinical Biochemistry, Polish-American Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Przemyslaw J
authors.initials: PJ
authors.lastname: Tomasik
authors.affiliation: Department of Immunology, Chair of Clinical Immunology and Transplantation, Jagiellonian University Medical College, Krakow, Poland; Transplantation Centre, University Children's Hospital, Krakow, Poland.
authors.forename: Jolanta
authors.initials: J
authors.lastname: Gozdzik
authors.affiliation: Department of Statistics, Cracow University of Economics, Krakow, Poland.
authors.forename: Kamil
authors.initials: K
authors.lastname: Fijorek
authors.affiliation: Transplantation Centre, University Children's Hospital, Krakow, Poland; Department of Transplantation, Chair of Clinical Immunology and Transplantation, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Krasowska-Kwiecien
authors.affiliation: Transplantation Centre, University Children's Hospital, Krakow, Poland.
authors.forename: Oktawiusz
authors.initials: O
authors.lastname: Wiecha
authors.affiliation: Transplantation Centre, University Children's Hospital, Krakow, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Czogala
authors.affiliation: Transplantation Centre, University Children's Hospital, Krakow, Poland.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Dluzniewska
authors.affiliation: Department of Clinical Biochemistry, Polish-American Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Sztefko
authors.affiliation: Department of Endocrinology, Polish-American Institute of Pediatrics, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Jerzy
authors.initials: J
authors.lastname: Starzyk
authors.affiliation: Department of Immunology, Chair of Clinical Immunology and Transplantation, Jagiellonian University Medical College, Krakow, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Siedlar
mesh_terms: D000293:Adolescent; D000328:Adult; D064591:Allografts; D064592:Autografts; D014408:Biomarkers, Tumor / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000097:blood* / Q000628:therapy*; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D016207:Cytokines; D002097:C-Reactive Protein; D054409:Nicotinamide Phosphoribosyltransferase; C504970:nicotinamide phosphoribosyltransferase, rat