title: Synthesis and biological evaluation of nonaprenylsulfates.
abstract: A naturally occurring nonaprenylsulfate (1) and its synthetic analogue (2) were synthesized from substituted phenolic precursors in three steps with an overall yield of 40-45%. Both compounds exhibited potent anti-inflammatory activity against 5-lipoxygenase, and potent brine shrimp lethality. They also showed moderate anti-oxidant activity in the super oxide radical scavenging model. Nonaprenylsulfate (1) showed moderate inhibition of paw edema in Freund's Complete Adjuvant (FCA) induced model of arthritis, thus confirming its anti-inflammatory activity.
authors.affiliation: Laila Impex R & D Center, Unit-I, Phase-III, Jawahar Autonagar, Vijayawada - 520 007, Andhra Pradesh, India.
authors.forename: Suryachandra R
authors.initials: SR
authors.lastname: Ravada
authors.affiliation: Laila Impex R & D Center, Unit-I, Phase-III, Jawahar Autonagar, Vijayawada - 520 007, Andhra Pradesh, India.
authors.forename: Lakshmareddy
authors.initials: L
authors.lastname: Emani
authors.affiliation: Laila Impex R & D Center, Unit-I, Phase-III, Jawahar Autonagar, Vijayawada - 520 007, Andhra Pradesh, India.
authors.forename: Ganeswara R
authors.initials: GR
authors.lastname: Mallula
authors.affiliation: Laila Impex R & D Center, Unit-I, Phase-III, Jawahar Autonagar, Vijayawada - 520 007, Andhra Pradesh, India.
authors.forename: Trimurtulu
authors.initials: T
authors.lastname: Golakoti
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D005260:Female; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013463:Sulfuric Acid Esters / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D013463:Sulfuric Acid Esters