title: Synthesis of pyridyl-dihydrobenzooxaphosphole ligands and their application in asymmetric hydrogenation of unfunctionalized alkenes.
abstract: Synthesis of the electron-rich 2-substituted-6-(phenylsulfonyl)pyridines is presented. A series of air-stable, tunable, P-chiral pyridyl-dihydrobenzooxaphosphole ligands were designed and synthesized by a diastereoselective S(N)Ar substitution of the corresponding sulfonyl pyridines. The ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of unfunctionalized alkenes with good enantioselectivities.
authors.forename: Bo
authors.initials: B
authors.lastname: Qu
authors.forename: Lalith P
authors.initials: LP
authors.lastname: Samankumara
authors.forename: Jolaine
authors.initials: J
authors.lastname: Savoie
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Fandrick
authors.forename: Nizar
authors.initials: N
authors.lastname: Haddad
authors.forename: Xudong
authors.initials: X
authors.lastname: Wei
authors.forename: Shengli
authors.initials: S
authors.lastname: Ma
authors.forename: Heewon
authors.initials: H
authors.lastname: Lee
authors.forename: Sonia
authors.initials: S
authors.lastname: Rodriguez
authors.forename: Carl A
authors.initials: CA
authors.lastname: Busacca
authors.forename: Nathan K
authors.initials: NK
authors.lastname: Yee
authors.forename: Jinhua J
authors.initials: JJ
authors.lastname: Song
authors.forename: Chris H
authors.initials: CH
authors.lastname: Senanayake
mesh_terms: D000475:Alkenes; D002384:Catalysis; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D017553:Phosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D008024:Ligands; D017553:Phosphorus Compounds; D011725:Pyridines; D007495:Iridium