title: No evidence of vancomycin minimal inhibitory concentration creep or heteroresistance identified in pediatric Staphylococcus aureus blood isolates.
abstract: We evaluated vancomycin minimum inhibitory concentration (MIC) trends by 3 methods (broth microdilution, Etest and Vitek 2) in 208 Staphylococcus aureus blood isolates from 2006 to 2009 and assessed for heteroresistance. Vancomycin MICs did not increase nor was heteroresistance identified. Etest yielded higher MIC results than the other 2 methods. No MIC was >2 µg/mL by any testing method.
authors.affiliation: From the *Division of Pediatric Infectious Diseases, Children's Mercy Hospitals and Clinics; †Department of Medicine, University of Missouri-Kansas City School of Medicine; and ‡Department of Microbiology, Children's Mercy Hospitals and Clinics, Kansas City, MO.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Goldman
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Harrison
authors.forename: Angela L
authors.initials: AL
authors.lastname: Myers
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Jackson
authors.forename: Rangaraj
authors.initials: R
authors.lastname: Selvarangan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D002648:Child; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000097:blood / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D014640:Vancomycin / Q000494:pharmacology*; D020713:Vancomycin Resistance
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin