title: One-minute exercise is best for evaluation of postexercise exhaustion in myasthenia gravis.
abstract: BACKGROUND
  To find the best exercise duration for postexercise exhaustion by decrement (PEE-D) in myasthenia gravis (MG).
  
  
  METHODS
  In 32 tests in 32 MG patients, repetitive nerve stimulation was performed in the abductor digiti quinti muscle. The 3 Hz responses for 2 s were obtained with supramaximal stimulation at rest, and immediately after (PE0), 30 s after (PE30s), and 1, 2, 3, and 4 min after 10-s, 30-s, and 1-min exercises.
  
  
  RESULTS
  Compared with the decrement at rest, a significantly greater decrement was found at PE2m and PE3m after 30-s exercise, and at PE2m, PE3m, and PE4m after 1-min exercise. In 11 patients who showed a decremental response only with exercise, PEE-D was observed in 5 after 30-s exercise and in 8 after 1-min exercise.
  
  
  CONCLUSIONS
  One-minute exercise is best for evaluation of PEE-D in MG.
authors.affiliation: Department of Neurology, University of Alabama at Birmingham, UAB Station, Birmingham, Alabama, USA, 35294.
authors.forename: Shin J
authors.initials: SJ
authors.lastname: Oh
authors.forename: Taiichi
authors.initials: T
authors.lastname: Nagai
authors.forename: Ferah
authors.initials: F
authors.lastname: Kizilay
authors.forename: Semiha
authors.initials: S
authors.lastname: Kurt
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000328:Adult; D000368:Aged; D000906:Antibodies; D004558:Electric Stimulation; D004576:Electromyography; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018763:Muscle Fatigue / Q000502:physiology*; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000503:physiopathology; D009460:Neurologic Examination; D011446:Prospective Studies; D020794:Receptor Protein-Tyrosine Kinases / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology
chemical_list: D000906:Antibodies; D011950:Receptors, Cholinergic; C095714:MUSK protein, human; D020794:Receptor Protein-Tyrosine Kinases
keywords: MG; Myasthenia gravis; Repetitive nerve stimulation test; decremental response; postexercise exhaustion