title: Pancreatic neuroendocrine neoplasms - management guidelines (recommended by the Polish Network of Neuroendocrine Tumours).
abstract: We present revised diagnostic and therapeutic guidelines for the management of pancreatic neuroendocrine neoplasms (PNENs) proposed by the Polish Network of Neuroendocrine Tumours.These guidelines refer to biochemical (determination of specific and nonspecific neuroendocrine markers) and imaging diagnostics (EUS, CT, MR, and radioisotope examination with a 68Ga or 99Tc labelled somatostatin analogue).A histopathological diagnostic, which determines the further management of patients with PNENs, must be necessarily confirmed by immunohistochemical tests. PNENs therapy requires collaboration between a multidisciplinary team of specialists experienced in the management of these neoplasms. Surgery is the basic form of treatment. Medical therapy requires a multidirectional procedure, and therefore the rules of biotherapy, peptide receptor radionuclide therapy, chemotherapy and molecular targeted therapy are discussed.
authors.affiliation: Division of Endocrinology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Katowice, Poland. endoklin@sum.edu.pl.
authors.forename: Beata
authors.initials: B
authors.lastname: Kos-Kudła
authors.forename: Alicja
authors.initials: A
authors.lastname: Hubalewska-Dydejczyk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Kuśnierz
authors.forename: Paweł
authors.initials: P
authors.lastname: Lampe
authors.forename: Bogdan
authors.initials: B
authors.lastname: Marek
authors.forename: Anna
authors.initials: A
authors.lastname: Nasierowska-Guttmejer
authors.forename: Ewa
authors.initials: E
authors.lastname: Nowakowska-Duława
authors.forename: Joanna
authors.initials: J
authors.lastname: Pilch-Kowalczyk
authors.forename: Anna
authors.initials: A
authors.lastname: Sowa-Staszczak
authors.forename: Violetta
authors.initials: V
authors.lastname: Rosiek
mesh_terms: D002983:Clinical Competence; D004704:Endocrinology / Q000592:standards; D006801:Humans; D008495:Medical Oncology / Q000592:standards; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000628:therapy*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D011044:Poland; D011785:Quality Assurance, Health Care / Q000592:standards*