title: Risk of cytomegalovirus infection and disease after umbilical cord blood transplantation in children.
abstract: BACKGROUND
  Pediatric data regarding cytomegalovirus (CMV) infections in pediatric patients receiving umbilical cord blood (UCB) transplantation are sparse.
  
  
  OBJECTIVE
  To determine whether UCB transplantation increases the risk of CMV infection and disease compared with other graft sources.
  
  
  METHODS
  The medical files of patients who underwent allogeneic hematopoietic stem cell transplantation at CHU Ste-Justine (Montreal, Quebec) from April 2000 to December 2006 were retrospectively reviewed. A Cox proportional hazard model was used to assess the effect of potential predictors of outcomes.
  
  
  RESULTS
  A total of 176 patients with a median age of nine years (range 0.1 to 18 years) underwent hematopoietic stem cell transplantation. The source of stem cells were UCB, bone marrow and peripheral blood stem cells in 86, 86 and four of the cases, respectively. CMV infection occurred in 29 patients (16%). At day 100 post-transplantation, the rate of CMV infection was 13% in UCB transplant recipients (11 of 86) versus 20% in those with other sources of graft (18 of 90) (P=0.19). Positive CMV serology of the recipient and leukocyte depletion were two independent variables associated with an increased risk of CMV infection. Among infected patients, six developed CMV disease (20.7%). The rate of CMV disease one year after infection was 49% in patients who received UCB (five of 11) and 6% in others (one of 18). This difference was significant by univariate (P=0.01) but not by multivariate analysis.
  
  
  CONCLUSIONS
  In the setting of the current study, with a moderate CMV infection rate (16.5%), UCB transplantation did not appear to increase the risk of CMV infection and disease.
authors.affiliation: Infectious Diseases Division, Université de Montréal, Montréal, Québec;
authors.forename: Pierre Alex
authors.initials: PA
authors.lastname: Crisinel
authors.affiliation: Onco-Hematology Division, Université de Montréal, Montréal, Québec;
authors.forename: Michel
authors.initials: M
authors.lastname: Duval
authors.affiliation: Infectious Diseases Division, Université de Montréal, Montréal, Québec;
authors.forename: Delphine Thuillard
authors.initials: DT
authors.lastname: Crisinel
authors.affiliation: Department of Microbiology and Immunology CHU Ste-Justine - Université de Montréal, Montréal, Québec.
authors.forename: Brigitte
authors.initials: B
authors.lastname: Mallette
authors.affiliation: Onco-Hematology Division, Université de Montréal, Montréal, Québec;
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bellier
authors.affiliation: Onco-Hematology Division, Université de Montréal, Montréal, Québec;
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Vachon
authors.affiliation: Onco-Hematology Division, Université de Montréal, Montréal, Québec;
authors.forename: Laurence
authors.initials: L
authors.lastname: Dedeken
authors.affiliation: Department of Microbiology and Immunology CHU Ste-Justine - Université de Montréal, Montréal, Québec.
authors.forename: Céline
authors.initials: C
authors.lastname: Rousseau
authors.affiliation: Infectious Diseases Division, Université de Montréal, Montréal, Québec;
authors.forename: Bruce
authors.initials: B
authors.lastname: Tapiero
authors.affiliation: Infectious Diseases Division, Université de Montréal, Montréal, Québec;
authors.forename: Philippe
authors.initials: P
authors.lastname: Ovetchkine
keywords: Children; Cytomegalovirus; Hematopoietic stem cell transplant; Umbilical cord blood