title: Dramatic remission of nephrotic syndrome after unusual complication of mucormycosis in idiopathic membranous nephropathy.
abstract: Mucormycosis is a rare and fatal opportunistic infection occurring in severely immunocompromised patients. Here, we report, for the first time, on a 65-year-old man with idiopathic membranous nephropathy and moderate renal dysfunction who suffered from life-threatening pulmonary mucormycosis during immunosuppressive therapy. After amphotericin B (AmB) administration with a total accumulating dose of 1.5 g, not only has he recovered from this fatal infection, but also his nephrotic syndrome has entered complete and long-term remission without any continued corticosteroid and immunosuppressive therapy during the 6-year follow-up. Serum creatinine levels remained stable by adjusting the tolerable daily dose of AmB during the period of treatment.
authors.affiliation: Division of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Shuifuyuan 1, Wangfujing, Beijing, 100730, China, wenlyepumch@163.com.
authors.forename: Wenling
authors.initials: W
authors.lastname: Ye
authors.forename: Yingyi
authors.initials: Y
authors.lastname: Wang
authors.forename: Yubing
authors.initials: Y
authors.lastname: Wen
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.forename: Xuemei
authors.initials: X
authors.lastname: Li
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D015433:Glomerulonephritis, Membranous / Q000150:complications; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D008297:Male; D009091:Mucormycosis / Q000188:drug therapy* / Q000209:etiology; D009404:Nephrotic Syndrome / Q000209:etiology*; D012075:Remission, Spontaneous
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B