title: pH-responsive controlled-release system based on mesoporous bioglass materials capped with mineralized hydroxyapatite.
abstract: A controlled release system with pH-responsive ability has been presented. Mesoporous bioglass (MBG) was used as the drug carrier and a spontaneous mineralization method was adopted to cap the pores of the carrier with hydroxyapatite (HAp) and to restrict the drug release. It is a simple and green method to realize the ingenious pH-sensitive controlled release. The model drug, metformin hydrochloride (MH), was loaded simultaneously with the mineralization process. Due to the degradation of HAp at acid environments, the system shows well pH-sensitive drug release ability. The release kinetics can be easily adjusted by the mineralization time and the ion concentration of media. The system is recommended as a promising candidate as a pH-sensitive vehicle for drug controlled release to low pH tissues, such as inflammatory sites and tumors.
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Chunyu
authors.initials: C
authors.lastname: Yang
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Liru
authors.initials: L
authors.lastname: Cui
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Di
authors.initials: D
authors.lastname: Xiang
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, PR China.
authors.forename: Kun
authors.initials: K
authors.lastname: Cai
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, PR China. Electronic address: hiuminglin@gmail.com.
authors.forename: Huiming
authors.initials: H
authors.lastname: Lin
authors.affiliation: Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, College of Chemistry and Chemical Engineering, Harbin Normal University, Harbin 150025, PR China. Electronic address: qufengyu2013@gmail.com.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Qu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000737:chemistry*; D009584:Nitrogen / Q000737:chemistry; D016062:Porosity; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D008903:Minerals; D017886:Durapatite; D009584:Nitrogen
keywords: Bioglass mesoporous materials; Controlled-release; Mineralized hydroxyapatite; pH-responsive