title: Chaetoglobosin Y, a new cytochalasan from Chaetomium globosum.
abstract: Chaetoglobosin Y (1), was isolated from the endolichenic fungal strain Chaetomium globosum (No. 64-5-8-2), along with related six known cytochalasans, chaetoglobosin Fex (2), chaetoglobosin E (3), isochaetoglobosin D (4), chaetoglobosin G (5), cytoglobosin B (6), and cytoglobosin C (7). Their structures were determined by detailed spectroscopic analyses and comparison with those of the closely related compounds previously reported. The cytotoxicity to HCT-116 cell line of 2-7 was evaluated in vitro with doxorubicin as positive control.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Qi-Chang
authors.initials: QC
authors.lastname: Zheng
authors.affiliation: Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, PR China.
authors.forename: Ming-Zhu
authors.initials: MZ
authors.lastname: Kong
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Department of Pharmaceutical Engineering, South China Agricultural University, Guangzhou 510642, PR China. Electronic address: chgdtong@163.com.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Chen
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Tian
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China.
authors.forename: Xiao-Xia
authors.initials: XX
authors.lastname: Li
authors.affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China.
authors.forename: Liang-Dong
authors.initials: LD
authors.lastname: Guo
authors.affiliation: National Center for Drug Screening, and State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai 201203, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.affiliation: Shenzhen Key Laboratory of Microbial Genetic Engineering, College of Life Sciences, Shenzhen University, Shenzhen 518060, PR China.
authors.forename: Yi-Zhi
authors.initials: YZ
authors.lastname: Zheng
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, PR China. Electronic address: tghao@jnu.edu.cn.
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis; D002597:Chaetomium / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D026121:Indole Alkaloids; C019290:chaetoglobosins
keywords: Chaetoglobosins; Chaetomiaceae; Chaetomium globosum; Cytochalasans; Cytotoxicity