title: Microchannel-based surface-enhanced Raman spectroscopy for integrated microfluidic analysis.
abstract: We have demonstrated a microchannel-based, surface-enhanced Raman spectroscopy (SERS) sensing approach for integrated microfluidic analysis developed using standard micro-fabrication technology. Our approach allows high-sensitivity SERS sensing with a comparatively low-excitation optical power intensity and large cross-sectional microchannel for biological cell analysis. Utilizing a microchannel with a cross section of 100 × 70 μm(2), we achieved a detection limit smaller than 10 nM for rhodamine 6G at an excitation power intensity of 132 W/cm(2), avoiding any possible heating effects on the sample under investigation. There is great potential for further improvement in the sensitivity of this microchannel-based SERS detection.
authors.affiliation: Key Laboratory of Optoelectronic Technology and Systems (Chongqing University), Ministry of Education, Key Disciplines Lab of Novel Micro-nano Devices and System Technology, and School of Optoelectronics Engineering, Chongqing University, Shapingba, Chongqing 400044, China.
authors.forename: Chun-hong
authors.initials: CH
authors.lastname: Lai
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.forename: Chun-yan
authors.initials: CY
authors.lastname: Wang