title: Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet.
abstract: Xanthohumol is the major prenylated flavonoid of female inflorescences of the hop plant (Humulus lupulus L.) and is a hydrophobic flavonoid. We examined the effects of dietary xanthohumol-rich hop extract in obese rats that was induced by feeding a high-fat diet. Dietary xanthohumol-rich hop extract significantly lowered the body weight gain of these rats compared to rats fed a high-fat diet without the extract. The increase of body weight, liver weight, and triacylglycerol levels in the plasma and liver of the rats fed a high-fat diet was ameliorated by dietary xanthohumol-rich hop extract. Dietary xanthohumol-rich hop extract tended to reduce hepatic fatty acid synthesis through the reduction of hepatic SREBP1c mRNA expression in the rats fed a high-fat diet. The excreted of triacylglycerol into feces also was promoted by dietary xanthohumol-rich hop extract. Plasma adiponectin levels in the rats fed a high-fat diet also tended to be elevated by dietary xanthohumol-rich hop extract. Thus, xanthohumol-rich hop extract may inhibit the increase of body weight, liver weight, and triacylglycerol in the plasma and liver induced by feeding high-fat diet through the regulation of hepatic fatty acid metabolism and inhibition of intestinal fat absorption. Therefore, xanthohumol-rich hop extract may exert preventive function on the increase of body weight and tissue triacylglycerol levels by overnutrition.
authors.affiliation: Department of Agricultural Chemistry, School of Agriculture, Meiji University.
authors.forename: Kazuki
authors.initials: K
authors.lastname: Yui
authors.forename: Ayane
authors.initials: A
authors.lastname: Kiyofuji
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Osada
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D019440:Anti-Obesity Agents; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000008:administration & dosage*; D005227:Fatty Acids / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D005419:Flavonoids / Q000008:administration & dosage* / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D027582:Humulus; D007408:Intestinal Absorption / Q000187:drug effects; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009765:Obesity / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology*; D011427:Propiophenones / Q000008:administration & dosage* / Q000494:pharmacology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D051782:Sterol Regulatory Element Binding Protein 2 / Q000235:genetics; D014280:Triglycerides / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
chemical_list: D052242:Adiponectin; D019440:Anti-Obesity Agents; D004041:Dietary Fats; D005227:Fatty Acids; D005419:Flavonoids; D010936:Plant Extracts; D011427:Propiophenones; D012333:RNA, Messenger; D051782:Sterol Regulatory Element Binding Protein 2; D014280:Triglycerides; C104536:xanthohumol