title: [Perilla nankinensis Decne by using melt granulation method].
abstract: The aim of the research was to work out the technology and tablet composition from the overground parts of the Perilla nankinensis Decne on the base of complex research. The dry extract was prepared from dried overground parts of perilla introduced in Georgia. The structural-mechanical and technological character of tablets and their masses were identified by the known methodic. Friability was studied by defining the fluctuation and bending corner. Volume density was established by using vibration cylinder. Volume density of powders was studied by pyknometers. Porosity was calculated by the bearing of volume density of the masses. The size of pressing was established by defining the firmness of tablets. The granule composition was defined by analysis. Disintegration and dissolution were studied by using "rotating basket" and "basket-rack assembly". From the result we got it was clear that the dry extract for research don't have good fluctuation and pressing. It should be mentioned that it contained moisture and is hygroscopic. As the character of substances is not satisfied it was necessary to select new assisting substances and studying and using additional technological method. We have selected some more additional substances for optimal firmness and for the purpose of shortening the time of tablet dissolution. There were also selected parameters of optimal pressing force. Assisting substances are practically selected and theoretically accepted on the base of studying technological and physical-chemical character features of the substances of the dry extract from the over ground parts of Perilla nankinensis Decne. As a result optimal composition of tablets is delivered. It is also scientifically proved and practically offered optimal technological parameters of tablets forming melt granulation method.
authors.forename: N B
authors.initials: NB
authors.lastname: Shashiashvili
authors.forename: D T
authors.initials: DT
authors.lastname: Berashvili
authors.forename: L A
authors.initials: LA
authors.lastname: Bakuridze
authors.forename: A D
authors.initials: AD
authors.lastname: Bakuridze
mesh_terms: D004339:Drug Compounding; D005846:Georgia (Republic); D006801:Humans; D031343:Perilla / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013607:Tablets / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; D013607:Tablets