title: T1-T2 dual-modal MRI of brain gliomas using PEGylated Gd-doped iron oxide nanoparticles.
abstract: To overcome the negative contrast limitations of iron oxide-based contrast agents and to improve the biocompatibility of Gd-chelate contrast agents, PEGylated Gd-doped iron oxide (PEG-GdIO) NPs as a T1-T2 dual-modal contrast agent were synthesized by the polyol method. The transverse relaxivity (r2) and longitudinal relaxivity (r1) of PEG-GdIO were determined to be 66.9 and 65.9 mM(-1) s(-1), respectively. The high r1 value and low r2/r1 ratio make PEG-GdIO NPs suitable as a T1-T2 dual-modal contrast agent. The in vivo MRI demonstrated a brighter contrast enhancement in T1-weighted image and a simultaneous darken effect in T2-weighted MR image compared to the pre-contrast image in the region of glioma. Furthermore, the biocompatibility of PEG-GdIO NPs was confirmed by the in vitro MTT cytotoxicity and in vivo histological analyses (H&E). Therefore, PEG-GdIO NPs hold great potential in T1-T2 dual-modal imaging for the diagnosis of brain glioma.
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Xiao
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Gu
authors.affiliation: Regeneration and Repair, Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Capital Medical University, Beijing 100069, PR China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Deng
authors.affiliation: School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Shi
authors.affiliation: School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China. Electronic address: lingye@ccmu.edu.cn.
authors.forename: Ling
authors.initials: L
authors.lastname: Ye
mesh_terms: D000818:Animals; D001692:Biological Transport; D001932:Brain Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000138:chemical synthesis* / Q000378:metabolism; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000378:metabolism; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D005910:Glioma / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D009374:Neoplasms, Experimental; D009942:Organometallic Compounds / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D009942:Organometallic Compounds; C510452:gadolinium acetylacetonate; D011092:Polyethylene Glycols; D052203:Ferrosoferric Oxide
keywords: Brain glioma; Dual-modal contrast agent (CA); Gd-doped iron oxide (IO); MRI