title: Polypoidal choroidal vasculopathy and systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) associated with antiphospholipid syndrome can have ocular complications. We report a 44-year-old Chinese lady with recurrent relapses of SLE and antiphospholipid syndrome with high disease activity, presenting with visual distortion in her right eye for 2 months. There was subretinal hemorrhage in her right eye, confirmed on investigations to be choroidal neovascularization secondary to a variant of age-related macular degeneration known as polypoidal choroidal vasculopathy (PCV). Anti-vascular endothelial growth factor therapy resolved her eye condition. SLE could be associated with PCV via common mechanisms, including complement pathway activation and vasculitis involving the choroidal circulation.
authors.affiliation: 1Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
authors.forename: Y C
authors.initials: YC
authors.lastname: Chin
authors.forename: M
authors.initials: M
authors.lastname: Bhargava
authors.forename: C C
authors.initials: CC
authors.lastname: Khor
authors.forename: C M G
authors.initials: CM
authors.lastname: Cheung
authors.forename: T Y
authors.initials: TY
authors.lastname: Wong
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D017152:Antibodies, Antiphospholipid / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002832:Choroid Hemorrhage / Q000209:etiology; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008268:Macular Degeneration / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D010778:Photochemotherapy; D012008:Recurrence; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology
chemical_list: D020533:Angiogenesis Inhibitors; D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D007166:Immunosuppressive Agents
keywords: Systemic lupus erythematosus; age-related macular degeneration; antiphospholipid syndrome; polypoidal choroidal vasculopathy