title: Prp4 kinase is required for proper segregation of chromosomes during meiosis in Schizosaccharomyces pombe.
abstract: Chromosome segregation during meiosis is a complex process, which leads to production of four haploid gametes from two precursor cells. Reversible phosphorylation of proteins plays a crucial role in this process. The Schizosaccharomyces pombe Prp4 is an essential serine/threonine protein kinase, which belongs to the Clk/Sty family. To study the role of Prp4 in meiosis, we analysed chromosome segregation in a strain carrying conditional analog-sensitive allele of Prp4 protein kinase (prp4-as2). Our data show, that Prp4 protein kinase plays important role in chromosome segregation during meiosis, as revealed by enhanced missegregation of chromosomes in prp4-as2 mutant cells.
authors.affiliation: Slovak University of Agriculture, Department of Genetics and Breeding Biology, Nitra, Slovakia.
authors.forename: Miroslava
authors.initials: M
authors.lastname: Pozgajova
authors.affiliation: Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia.
authors.forename: Lubos
authors.initials: L
authors.lastname: Cipak
authors.affiliation: Slovak University of Agriculture, Department of Genetics and Breeding Biology, Nitra, Slovakia.
authors.forename: Anna
authors.initials: A
authors.lastname: Trakovicka
mesh_terms: D020090:Chromosome Segregation / Q000235:genetics*; D002875:Chromosomes / Q000235:genetics; D015966:Gene Expression Regulation, Fungal; D008540:Meiosis / Q000235:genetics*; D009154:Mutation; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D000072260:RNA Splicing Factors; D017414:Ribonucleoprotein, U4-U6 Small Nuclear / Q000235:genetics*; D012568:Schizosaccharomyces / Q000235:genetics; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics*
chemical_list: D000072260:RNA Splicing Factors; D017414:Ribonucleoprotein, U4-U6 Small Nuclear; D029702:Schizosaccharomyces pombe Proteins; D017346:Protein Serine-Threonine Kinases; C489981:prp4 protein, S pombe