title: The palliative index: predicting outcomes of emergent surgery in patients with cancer.
abstract: BACKGROUND
  The role of emergent palliative surgery in the setting of advanced malignancy remains a subject of controversy.
  
  
  OBJECTIVE
  The purpose of this study was to identify clinical predictors of outcome in patients with cancer who undergo nonelective abdominal surgery.
  
  
  METHODS
  Individuals who underwent urgent and emergent abdominal operations between 2006 and 2010 at a tertiary cancer center were identified.
  
  
  METHODS
  Analyses were performed to identify predictors of 30-day morbidity and mortality as well as overall survival (OS). A risk score was derived from predictors of OS.
  
  
  RESULTS
  Of 143 patients, 93 (65%) had active disease (AD; defined as evidence of malignancy at time of surgery). Thirty-day morbidity and mortality were 36.4% and 9.8%, respectively. Independent predictors of 30-day mortality included ASA score >3 (p=0.009) and albumin <2.8 (p=0.040). Median OS was 5.4 months in patients with AD and was not reached in patients without AD (p<0.001). Independent predictors of decreased OS included AD; ASA >3; creatinine >1.3; and a tumor-related indication (i.e., bleeding, obstructing, or perforating tumor). A risk or palliative index (PI) score stratified patients into groups with discreet outcomes.
  
  
  CONCLUSIONS
  Although AD did not predict 30-day morbidity, it was the dominant independent predictor of postoperative OS. In cancer patients undergoing emergency abdominal surgery, outcome is anticipated by disease status and other independent predictors of OS.
authors.affiliation: 1 Department of Surgery, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania.
authors.forename: Robert E
authors.initials: RE
authors.lastname: Roses
authors.forename: Ching-Wei D
authors.initials: CW
authors.lastname: Tzeng
authors.forename: Merrick I
authors.initials: MI
authors.lastname: Ross
authors.forename: Keith F
authors.initials: KF
authors.lastname: Fournier
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Abbott
authors.forename: Y Nancy
authors.initials: YN
authors.lastname: You
mesh_terms: D000006:Abdomen, Acute / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002173:Cancer Care Facilities / Q000706:statistics & numerical data; D004638:Emergency Treatment / Q000379:methods / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000601:surgery; D010166:Palliative Care / Q000379:methods / Q000592:standards*; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult