title: [Pathophysiology of primary Sjögren's syndrome].
abstract: Primary Sgögren's syndrome (SSP) is one of the most common connective tissue disorder with an estimated prevalence between 0.6 and 1.7% of the general population. Lymphocytic infiltration of salivary gland is easily accessible favoring the diagnosis, and clinical and fundamental research. However, while many advances have been obtained in the recent decades, the pathophysiology of SSP remains unclear combining environmental factors with genetic predisposition. A central role tends to be attributed to salivary gland epithelial cells, originally designated as "innocent bystanders" and to B cells through the intervention of survey factors like BAFF. New T cells subsets are also carefully studied, particularly natural T regulatory and Th17 cells. They could indeed represent new therapeutic targets.
authors.affiliation: Service de médecine interne A, CHU Dupuytren, 4, avenue Martin-Luther-King, 87000 Limoges, France.
authors.forename: C
authors.initials: C
authors.lastname: Martel
authors.affiliation: Laboratoire d'immunologie, EA3842, CHU Dupuytren, 4, avenue Martin-Luther-King, 87000 Limoges, France.
authors.forename: M-O
authors.initials: MO
authors.lastname: Jauberteau
authors.affiliation: Service de médecine interne A, CHU Dupuytren, 4, avenue Martin-Luther-King, 87000 Limoges, France.
authors.forename: E
authors.initials: E
authors.lastname: Vidal
authors.affiliation: Service de médecine interne A, CHU Dupuytren, 4, avenue Martin-Luther-King, 87000 Limoges, France; Laboratoire d'immunologie, EA3842, CHU Dupuytren, 4, avenue Martin-Luther-King, 87000 Limoges, France. Electronic address: anne-laure.fauchais@unilim.fr.
authors.forename: A-L
authors.initials: AL
authors.lastname: Fauchais
mesh_terms: D000465:Algorithms; D000974:Antibodies, Antinuclear / Q000276:immunology*; D053264:B-Cell Activating Factor / Q000276:immunology*; D015415:Biomarkers / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D012307:Risk Factors; D012720:Severity of Illness Index; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D058504:Th17 Cells / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D053264:B-Cell Activating Factor; D015415:Biomarkers; C035357:SS-B antibodies; D051193:Toll-Like Receptors
keywords: Anti-SSA; Anti-SSB; B cells; BAFF; Lymphocytes B; Sjögren syndrome; Syndrome de Sjögren primitif