title: The use of platelet-rich plasma gel in patients with mixed tumour undergoing superficial parotidectomy: a randomized study.
abstract: OBJECTIVE
  Salivary gland tumors are mostly benign tumors. Whether a more conservative surgical approach at greater risk of recurrence, or a more radical intervention with an increased risk of facial paralysis is warranted is still under discussion. Our study addresses the opportunity for improving surgical outcome by employing platelet-rich plasma (PRP) gel at the surgical site.
  
  
  METHODS
  Twenty consecutive patients undergoing superficial parotidectomy were randomized and assigned to two groups, one with and one without PRP gel. Many parameters were evaluated after surgery and during follow-up, such as the duration of hospitalization, facial nerve deficit, onset of Frey's syndrome, relapse, cosmetic results, presence of keloid or scar depressions, behavior of several facial muscles.
  
  
  RESULTS
  Our explorative analysis suggests a positive effect of PRP on surgical outcome in patients undergoing parotidectomy, whereas no negative effects were detected.
  
  
  CONCLUSIONS
  This work suggests that administration of PRP in patients undergoing parotidectomy is beneficial.
authors.affiliation: S.C. Chirurgia Plastica e Ricostruttiva, IRCCS San Martino - IST, L.go R. Benzi, 10, 16132 Genoa, Italy. francesco.spagnolo85@gmail.com.
authors.forename: Marco
authors.initials: M
authors.lastname: Scala
authors.forename: Paola
authors.initials: P
authors.lastname: Mereu
authors.forename: Francesco
authors.initials: F
authors.lastname: Spagnolo
authors.forename: Michela
authors.initials: M
authors.lastname: Massa
authors.forename: Annalisa
authors.initials: A
authors.lastname: Barla
authors.forename: Sofia
authors.initials: S
authors.lastname: Mosci
authors.forename: Gilberto
authors.initials: G
authors.lastname: Forno
authors.forename: Andra
authors.initials: A
authors.lastname: Ingenito
authors.forename: Paolo
authors.initials: P
authors.lastname: Strada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005782:Gels / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D053657:Platelet-Rich Plasma / Q000737:chemistry*; D011183:Postoperative Complications; D044968:Regenerative Medicine; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D005782:Gels
keywords: Regenerative medicine; parotidectomy; platelet gel; platelet-rich plasma; salivary gland tumors