title: Mucoadhesive microspheres containing anti-hypertensive agent: formulation and characterization.
abstract: The spherical microspheres consisting of Furosemide loaded sodium alginate and along with HPMC E50 or sodium CMC as mucoadhesive polymers in different ratios were prepared using ionic gelation technique. Calcium chloride was used as crosslinking, to retard the drug release from the mucoadhesive microspheres. The prepared mucoadhesive microspheres were subjected for evaluation of various parameters like production yield, particle size, encapsulation efficiency, mucoadhesion test and in vitro dissolution profile studies. Formulations were subjected to DSC study and SEM analysis. The in vitro release data were well fit into Higuchi and Korsmeyer-Peppas model and followed non-Fickian diffusion mechanism.
authors.forename: Ankita Sunilbhai
authors.initials: AS
authors.lastname: Patel
authors.forename: Pande
authors.initials: P
authors.lastname: Saikat
authors.affiliation: A.R. College of Pharmacy & G.H. Patel Institute of Pharmacy, Vallabh Vidyanagar, Anand, Gujarat, India. ankita2305patel@gmail.com.
authors.forename: Patel Ronakkumar
authors.initials: PR
authors.lastname: Pravinbhai
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry*; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D005665:Furosemide / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D065347:Hypromellose Derivatives / Q000737:chemistry; D007413:Intestinal Mucosa / Q000737:chemistry; D008863:Microspheres; D009093:Mucus / Q000737:chemistry; D010316:Particle Size; D051381:Rats; D012995:Solubility
chemical_list: D000464:Alginates; D000959:Antihypertensive Agents; D006603:Hexuronic Acids; D065347:Hypromellose Derivatives; D005665:Furosemide; D020723:Glucuronic Acid; D002266:Carboxymethylcellulose Sodium