title: Correlation between serum IL-1beta levels and cerebral edema extent in a hypertensive intracerebral hemorrhage rat model.
abstract: BACKGROUND
  Interleukin-1beta (IL-1beta) is a pro-inflammatory cytokine that is increased following hypertensive intracerebral hemorrhage (ICH), potentially related to neural damage by cerebral edema.
  
  
  OBJECTIVE
  To investigate the correlation between post-ICH serum IL-1beta and cerebral edema in a hypertensive rat model.
  
  
  METHODS
  We used 30 successful ICH male spontaneously hypertensive rats (SHR) subjected to autologous blood infusion and displaying behavioral abnormalities (ICH group), and 30 sham-operated rats. Cerebral edema was assessed at 8, 16, 24, 48, 72, and 120 hours using dry and wet right hemisphere weighing, and serum IL-1beta levels were determined by enzyme-linked immunosorbent assay (ELISA). Nonlinear regression was performed between serum IL-1beta levels and cerebral edema extent at different time intervals after ICH.
  
  
  RESULTS
  No significant difference was observed in preoperative blood pressure between the two groups. In ICH rats, behavioral abnormalities were observed at all time points except at 120 hours Intracerebral hemorrhage rats exhibited significantly increased serum IL-1beta levels between 16 and 72 hours, and increased cerebral edema between 24 and 72 hours (all P < 0·05 vs sham-operated rats), but no significant differences were found in the sham-operated group. Serum IL-1beta and cerebral edema in the ICH group returned to baseline by 120 hours Serum IL-1beta levels were positively correlated with cerebral edema (r  =  0·906, P  =  0·001).
  
  
  CONCLUSIONS
  Serum IL-1beta was related to cerebral edema extent in hypertensive ICH rats, which may eventually be useful as an indicator for progression of cerebral edema after ICH, and contributing to the choice of a treatment strategy.
authors.forename: Pingbo
authors.initials: P
authors.lastname: Wei
authors.forename: Chao
authors.initials: C
authors.lastname: You
authors.forename: Hong
authors.initials: H
authors.lastname: Jin
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Bin
authors.initials: B
authors.lastname: Lin
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D001921:Brain / Q000473:pathology* / Q000601:surgery; D001929:Brain Edema / Q000097:blood* / Q000209:etiology / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000150:complications / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D009043:Motor Activity; D017711:Nonlinear Dynamics; D011897:Random Allocation; D051381:Rats; D011918:Rats, Inbred SHR; D012044:Regression Analysis; D013997:Time Factors
chemical_list: D053583:Interleukin-1beta
keywords: Cerebral edema,; Hypertension; IL-1beta,; Intracerebral hemorrhage,