title: Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis.
abstract: We performed this meta-analysis to assess venous thromboembolism risk in patients with rheumatoid arthritis. A comprehensive search was performed in MEDLINE, EMBASE, and the Cochrane databases. Nine observational studies met our inclusion criteria and were included in the data analysis. The pooled risk ratios of deep venous thrombosis, pulmonary embolism, and venous thromboembolism in patients with rheumatoid arthritis (RA) compared with non-RA participants were 2.08 (95% CI 1.75-2.47), 2.17 (95% CI 2.05-2.31), and 1.96 (95% CI 1.81-2.11), respectively. Subgroup analysis demonstrated a consistent increased risk in every study design (cohort, case-control, and cross-sectional). Our results indicate a significant increased risk of venous thromboembolism among patients with rheumatoid arthritis.
authors.affiliation: Department of Internal Medicine, Bassett Medical Center and Columbia University College of Physicians and Surgeons, Cooperstown, NY, USA, patompong.ungprasert@bassett.org.
authors.forename: Patompong
authors.initials: P
authors.lastname: Ungprasert
authors.forename: Narat
authors.initials: N
authors.lastname: Srivali
authors.forename: Ittikorn
authors.initials: I
authors.lastname: Spanuchart
authors.forename: Charat
authors.initials: C
authors.lastname: Thongprayoon
authors.forename: Eric L
authors.initials: EL
authors.lastname: Knight
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications*; D006801:Humans; D012306:Risk; D054556:Venous Thromboembolism / Q000209:etiology*