title: [Preparation of self-microemulsion drug delivery system of the mixture of paeonol and borneol based on Xingbi Fang].
abstract: The aim of this study is to prepare self-microemulsifying drug delivery system (SMEDDS) of the mixture of paeonol (Pae) and borneol (Bor). Solubility test, ternary phase diagrams and simplex lattice method were employed to screen and optimize the formulation of the mixture of Pae and Bor-loaded SMEDDS. After formed into microemulsions, the particle diameter (PD) was determined and a TEM was employed to observe the microemulsions' morphology. The contents of Pae and Bor were determined by gas chromatography. As a result, while ethyl oleate (EO) as the oil phase, cremophor EL35 (EL35) as surfactant and Transcutol HP (HP) as cosurfactant, the range of the microemulsion on the ternary phase diagram was larger than other combinations. And at a ratio of 20:45:35, the microemulsions' PD was about 34 nm and the polydispersity index (PI) was about 0.2. There were 16% of Pae, 2% of Bor, 16% of EO, 37% of EL35 and 29% of HP in the prepared SMEDDS. The preparation process of the Pae and Bor-loaded SMEDDS based on Xingbi Fang is simple and feasible. This study provides a reference for the researches on the related traditional Chinese medicine and the related components.
authors.affiliation: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
authors.forename: Feng-Qin
authors.initials: FQ
authors.lastname: Lü
authors.affiliation: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Li
authors.affiliation: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.affiliation: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
authors.forename: Xun
authors.initials: X
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Huang
authors.affiliation: Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zheng
authors.affiliation: School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
authors.forename: Ke-Dan
authors.initials: KD
authors.lastname: Chu
mesh_terms: D000098:Acetophenones / Q000008:administration & dosage* / Q000633:toxicity; D000281:Administration, Intranasal; D000818:Animals; D002025:Bufonidae; D001892:Camphanes / Q000008:administration & dosage* / Q000633:toxicity; D002923:Cilia / Q000187:drug effects; D004338:Drug Combinations; D016503:Drug Delivery Systems / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000633:toxicity; D004655:Emulsions; D005026:Ethylene Glycols / Q000737:chemistry; D005260:Female; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects; D009829:Oleic Acids / Q000737:chemistry; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry; D012995:Solubility; D013501:Surface-Active Agents / Q000737:chemistry
chemical_list: D000098:Acetophenones; D001892:Camphanes; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D005026:Ethylene Glycols; D009829:Oleic Acids; D013501:Surface-Active Agents; C022131:cremophor; C013638:paeonol; D011092:Polyethylene Glycols; C010111:carbitol; C022871:isoborneol; C033180:ethyl oleate