title: Low-volume exercise training and vitamin E supplementation attenuates oxidative stress in postmenopausal women.
abstract: The purpose of this study was to investigate the effects of low-volume exercise training (90 min/wk) and vitamin E supplementation on oxidative stress markers in postmenopausal women. The participants were non-randomly assigned the following four groups: control (C, n=8), vitamin E (S, n=8), exercise (Ex, n=6), or vitamin E and exercise (S+Ex, n=7). The S and S+Ex groups were instructed to take vitamin E (α-tocopherol, 300 mg/d) capsules for 12 wk. The exercise program of Ex and S+Ex groups consisted of walking for a 30-60 min/session 2 d per week for 12 wk. The serum derivatives of reactive oxygen metabolites concentrations were significantly decreased in the Ex, and S+Ex groups after 12 wk compared with the baseline values (three-factor ANOVA, an interaction between exercise and time, p<0.05). Conversely, serum biological antioxidant potential concentrations in the S and Ex groups were significantly higher at 12 wk than at the baseline, but not in the S+Ex group (three-factor ANOVA, an interaction between supplementation, exercise and time, p<0.05). Plasma thioredoxin concentrations in the S, Ex, and S+Ex groups were significantly higher at 12 wk than at the baseline values (three-factor ANOVA, interactions between exercise and time, and between supplementation, exercise and time, p<0.05). Our findings suggest that low-volume physical activity may improve resting oxidative stress status in postmenopausal women.
authors.affiliation: Graduate School of Sport Sciences, Waseda University.
authors.forename: Masaki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Masashi
authors.initials: M
authors.lastname: Miyashita
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Park
authors.forename: Noriaki
authors.initials: N
authors.lastname: Kawanishi
authors.forename: Seong-ryu
authors.initials: SR
authors.lastname: Bae
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Shizuo
authors.initials: S
authors.lastname: Sakamoto
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D000375:Aging; D000975:Antioxidants / Q000032:analysis / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D019587:Dietary Supplements; D015444:Exercise; D005260:Female; D006293:Health Promotion; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D018384:Oxidative Stress; D017698:Postmenopause; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000097:blood; D012306:Risk; D013879:Thioredoxins / Q000819:agonists / Q000097:blood; D014810:Vitamin E / Q000627:therapeutic use*; D016138:Walking; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species; D014810:Vitamin E; D013879:Thioredoxins; D024502:alpha-Tocopherol