title: Grb10 is a dual regulator of receptor tyrosine kinase signaling.
abstract: The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras-GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine kinases in a tyrosine phosphorylation dependent or independent manner. Association with multiple proteins allows Grb10 to regulate different signaling pathways resulting in different biological consequences.
authors.affiliation: Laboratory of Computational Biochemistry, KN Biomedical Research Institute, Bagura Road, Barisal, Bangladesh.
authors.forename: Nuzhat N
authors.initials: NN
authors.lastname: Kabir
authors.forename: Julhash U
authors.initials: JU
authors.lastname: Kazi
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D066246:ErbB Receptors / Q000378:metabolism; D051383:GRB10 Adaptor Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D054730:Protein Interaction Domains and Motifs; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D011972:Receptor, Insulin / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism; D015398:Signal Transduction; D018909:src Homology Domains
chemical_list: D051383:GRB10 Adaptor Protein; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D011972:Receptor, Insulin; D040262:Receptors, Vascular Endothelial Growth Factor