title: mRNA 3'end processing: A tale of the tail reaches the clinic.
abstract: Recent advances reveal mRNA 3'end processing as a highly regulated process that fine-tunes posttranscriptional gene expression. This process can affect the site and/or the efficiency of 3'end processing, controlling the quality and the quantity of substrate mRNAs. The regulation of 3'end processing plays a central role in fundamental physiology such as blood coagulation and innate immunity. In addition, errors in mRNA 3'end processing have been associated with a broad spectrum of human diseases, including cancer. We summarize and discuss the paradigmatic shift in the understanding of 3'end processing as a mechanism of posttranscriptional gene regulation that has reached clinical medicine.
authors.affiliation: Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Ina
authors.initials: I
authors.lastname: Hollerer
authors.forename: Kerstin
authors.initials: K
authors.lastname: Grund
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Hentze
authors.forename: Andreas E
authors.initials: AE
authors.lastname: Kulozik
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D006402:Hematologic Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D039102:Poly(A)-Binding Proteins / Q000235:genetics / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000378:metabolism*; D039221:mRNA Cleavage and Polyadenylation Factors / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; D039102:Poly(A)-Binding Proteins; D012333:RNA, Messenger; D039221:mRNA Cleavage and Polyadenylation Factors