title: Will therapies that target tumour suppressor genes be useful in cancer treatment?
abstract: Human cancers represent one of the biggest challenges for modern societies. By 2020, cancer deaths worldwide could reach 10 million. Therefore, one of the important aims of science research is the improvement of anti-malignant treatment options to mitigate cancer-related morbidity and mortality. This essay summarises current trends and future directions of target tumour suppressor genes therapies based on an example of one of the most promising targets, p53.
authors.affiliation: Hematology and Oncology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
authors.forename: Elwira
authors.initials: E
authors.lastname: Szychot
authors.forename: Andrzej
authors.initials: A
authors.lastname: Brodkiewicz
authors.forename: Jarosław
authors.initials: J
authors.lastname: Peregud-Pogorzelski
mesh_terms: D000818:Animals; D059248:Chemoradiotherapy; D016153:Genes, Suppressor; D016158:Genes, p53; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors*
chemical_list: D016159:Tumor Suppressor Protein p53