title: Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization.
abstract: Pattern recognition receptors (PRRs) are essential sentinels for pathogens or tissue damage and integral components of the innate immune system. Recent structural studies have provided unprecedented insights into the molecular mechanisms of ligand recognition and signal transduction by several PRR families at distinct subcellular compartments. Here we highlight some of the recent discoveries and summarize the common themes that are emerging from these exciting studies. Better mechanistic understanding of the structure and function of the PRRs will improve future prospects of therapeutic targeting of these important innate immune receptors.
authors.affiliation: Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 20892-0430.
authors.forename: Watchalee
authors.initials: W
authors.lastname: Chuenchor
authors.affiliation: Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 20892-0430.
authors.forename: Tengchuan
authors.initials: T
authors.lastname: Jin
authors.affiliation: Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 20892-0430.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Ravilious
authors.affiliation: Structural Immunobiology Unit, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA 20892-0430.
authors.forename: T Sam
authors.initials: TS
authors.lastname: Xiao
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D015536:Down-Regulation / Q000276:immunology*; D018390:Gene Targeting / Q000379:methods*; D006801:Humans; D007113:Immunity, Innate; D008024:Ligands; D005810:Multigene Family / Q000276:immunology; D011485:Protein Binding / Q000276:immunology; D055503:Protein Multimerization / Q000276:immunology*; D017434:Protein Structure, Tertiary; D051192:Receptors, Pattern Recognition / Q000737:chemistry* / Q000378:metabolism / Q000502:physiology*
chemical_list: D008024:Ligands; D051192:Receptors, Pattern Recognition