title: Carcinosarcoma of the uterus-a single institution retrospective analysis of the management and outcome and a brief review of literature.
abstract: Uterine carcinosarcomas are highly aggressive tumors of the uterus associated with a poor prognosis. Though initially classified as sarcomas, now these tumors are classified as carcinomas. The management approach of carcinosarcomas has also changed from those used for high grade sarcomas to that used for managing high grade endometrial carcinomas. The purpose of our study was to analyze the management and outcome of patients with uterine carcinosarcomas treated at our institution and also to attempt a brief review regarding the management of uterine carcinosarcomas. We did a retrospective analysis of all patients with a diagnosis of carcinosarcoma of the uterus treated at our Institution from January 2005 till December 2010. All Patients with a pathological diagnosis of carcinosacrcoma or malignant mixed mullerian tumours of the uterus were included. Data was obtained from the hospital electronic medical records and the hospital cancer registry. Data was analyzed using SPSS v.17. During this 6 year period we had 20 patients with carcinosarcoma of the uterus. 75 % of the patients belonged to Stage I and II. 95 % of the patients underwent Hysterectomy with Bilateral salpingo oophorectomy and 60 % had lymphadenectomy also along with hysterectomy.8 patients had disease recurrence . In patients who had gross extrauterine disease at the time of surgery , the survival was only 9 months whereas in patients who had complete staging with disease confined to the uterus , the survival was 36 months. Carcinosarcomas, accounts for more than 15 % of the uterine cancer associated deaths. Surgery remains the cornerstone of management for these tumors and surgery with pelvic and para aortic lymphadenectomy and peritoneal and omental biopsies is required for the correct staging of the disease and may also provide a survival advantage. Radiation therapy has been shown to provide only better local control without any survival advantage. Further studies are needed to assess whether chemotherapy offers a definite survival benefit in uterine carcinosarcomas.
authors.affiliation: Department of Surgical Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala India ; Department of Surgical Oncology, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi, Kerala India 682041.
authors.forename: Rajanbabu
authors.initials: R
authors.lastname: Anupama
authors.affiliation: Department of Gynecology, Medical College, Calicut, Kerala India.
authors.forename: Santhosh
authors.initials: S
authors.lastname: Kuriakose
authors.affiliation: Department of Surgical Oncology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala India.
authors.forename: D K
authors.initials: DK
authors.lastname: Vijaykumar
authors.affiliation: Department of Medical Oncology, Amrita Institute of Medical Sciences, Kochi, Kerala India.
authors.forename: K
authors.initials: K
authors.lastname: Pavithran
authors.affiliation: Department of Pathology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala India.
authors.forename: Annie
authors.initials: A
authors.lastname: Jojo
authors.affiliation: Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala India.
authors.forename: R Nair
authors.initials: RN
authors.lastname: Indu
authors.affiliation: Department of Biostatistics, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala India.
authors.forename: V S
authors.initials: VS
authors.lastname: Sheejamol
keywords: Carcinosarcoma uterus; MMMT uterus