title: Diffusion tensor MRI changes in gray structures of the frontal-subcortical circuits in amyotrophic lateral sclerosis.
abstract: In this study, we used an automated segmentation of regions of interest and co-registration to diffusion tensor imaging (DTI) images to investigate whether microstructural abnormalities occur in gray structures of the frontal-subcortical circuits in patients with amyotrophic lateral sclerosis (ALS). Twenty-four patients with probable or definite sporadic ALS and 22 healthy controls were enrolled in the study. Thirteen out of 24 ALS patients and all of the control subjects underwent a detailed neuropsychological evaluation. DTI was performed to measure mean diffusivity (MD) and fractional anisotropy in the frontal cortex, caudate, putamen, globus pallidus, thalamus, amygdala and hippocampus. MD values of ALS patients were significantly higher in the frontal cortex (P = 0.023), caudate (P = 0.01), thalamus (P = 0.019), amygdala (P = 0.012) and hippocampus (P = 0.002) compared to controls. MD of these structures significantly correlated to a variable degree with neurological disability and neuropsychological dysfunctions. The increased MD values in several cortical and subcortical gray structures and their correlations with neuropsychological variables substantiate a multisystemic degeneration in ALS and suggest that dysfunctions of frontal-subcortical circuits could play a pivotal role in frontal impairment and behavioral symptoms in ALS patients.
authors.affiliation: Institute of Neurology, University Magna Græcia, Catanzaro, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Barbagallo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nicoletti
authors.forename: Andrea
authors.initials: A
authors.lastname: Cherubini
authors.forename: Maria
authors.initials: M
authors.lastname: Trotta
authors.forename: Tiziana
authors.initials: T
authors.lastname: Tallarico
authors.forename: Carmelina
authors.initials: C
authors.lastname: Chiriaco
authors.forename: Rita
authors.initials: R
authors.lastname: Nisticò
authors.forename: Dania
authors.initials: D
authors.lastname: Salvino
authors.forename: Francesco
authors.initials: F
authors.lastname: Bono
authors.forename: Paola
authors.initials: P
authors.lastname: Valentino
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000679:Amygdala / Q000473:pathology; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology*; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D056324:Diffusion Tensor Imaging; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged