title: The role of the JAK-STAT pathway and related signal cascades in telomerase activation during the development of hematologic malignancies.
abstract: Telomerase, comprising a reverse transcriptase protein (TERT) and an RNA template, plays a critical role during senescence and carcinogenesis; however, the mechanisms by which telomerase is regulated remain to be elucidated. Several signaling pathways are involved in the activation of TERT at multistep levels. The JAK-STAT pathway is indispensable for mediating signals through growth factor and cytokine receptors during the development of hematopoietic cells, and its activity is frequently upregulated in hematological malignancies. Here, we review the role of the JAK-STAT pathway and related signaling cascades in the regulation of telomerase in hematological malignancies.
authors.affiliation: Medical Research Institute and Department of Hematology; Tokyo Women's Medical University; Tokyo, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yamada
authors.affiliation: Department of Medicine; Tokyo Women's Medical University; Medical Center East; Tokyo, Japan ; Nishiogu Clinic; Tokyo, Japan.
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Kawauchi
keywords: JAK; STAT; hematologic malignancy; signal transduction; telomerase