title: Neutrophil survival in the death zone.
abstract: In this issue of Blood, Thompson et al reveal a key role for hypoxia-inducible factor (HIF)-2a in the adaptation of neutrophils to hypoxia. Tissue hypoxia is a common feature of trauma and inflammation. Infiltrating neutrophils must adapt to this low-oxygen environment to satisfy the metabolic and functional demands of an immune response.
authors.affiliation: BOSTON CHILDREN'S HOSPITAL.
authors.forename: Ben A
authors.initials: BA
authors.lastname: Croker
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D009504:Neutrophils / Q000378:metabolism*; D000099162:Endothelial PAS Domain-Containing Protein 1
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D000099162:Endothelial PAS Domain-Containing Protein 1