title: Behçet's syndrome pathophysiology and potential therapeutic targets.
abstract: Behçet syndrome is a systemic inflammatory disorder characterized by multiorgan involvement such as oral and genital ulcers, uveitis, skin lesions as well as by less frequent, but often more severe, central nervous system and vascular manifestations. The pathogenetic mechanisms are still incompletely known; however the interaction between a specific genetic background and environmental or infectious factors certainly contributes to the immune dysregulation that characterizes this disease. The discovery of new immunological pathways in Behçet syndrome pathogenesis may help us to set up new treatments. In this review, we will focus our attention on the possible mechanisms underlying Behçet syndrome pathogenesis and their potential role as novel therapeutic targets.
authors.affiliation: Department of Experimental and Clinical Medicine, University of Florence, L.go G. Brambilla 3, 50134, Florence, Italy, giacomaci@yahoo.it.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Emmi
authors.forename: Elena
authors.initials: E
authors.lastname: Silvestri
authors.forename: Danilo
authors.initials: D
authors.lastname: Squatrito
authors.forename: Mario Milco
authors.initials: MM
authors.lastname: D'Elios
authors.forename: Lucia
authors.initials: L
authors.lastname: Ciucciarelli
authors.forename: Domenico
authors.initials: D
authors.lastname: Prisco
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Emmi
mesh_terms: D001528:Behcet Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D058990:Molecular Targeted Therapy