title: Autologous chondrocyte implantation for cartilage injury treatment in Chiang Mai University Hospital: a case report.
abstract: Autologous chondrocyte implantation (ACI) has become one of the standard procedures for articular cartilage defect treatment. This technique provides a promising result. However the procedural process requires an approach of several steps from multidisciplinary teams. Although the success of this procedure has been reported from Srinakharinvirot University since 2007, the application of ACI is still limited in Thailand due to the complexity of processes and stringent quality control. This report is to present the first case of the cartilage defect treatment using the first generation-ACI under Chiang Mai University's (CMU) own facility and Ethics Committee. This paper also reviews the process of biotechnology procedures, patient selection, surgical, and rehabilitation techniques. The success of the first case is an important milestone for the further development of the CMU Human Translational Research Laboratory in near future.
authors.affiliation: Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Prasit
authors.initials: P
authors.lastname: Wongtriratanachai
authors.affiliation: Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Dumnoensun
authors.initials: D
authors.lastname: Pruksakorn
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Peraphan
authors.initials: P
authors.lastname: Pothacharoen
authors.affiliation: Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Puwapong
authors.initials: P
authors.lastname: Nimkingratana
authors.affiliation: Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Nuttaya
authors.initials: N
authors.lastname: Pattamapaspong
authors.affiliation: Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Chanakarn
authors.initials: C
authors.lastname: Phornphutkul
authors.affiliation: Blood Bank Unit, Chiang Mai University Hospital, Chiang Mai, Thailand.
authors.forename: Sasiwariya
authors.initials: S
authors.lastname: Setsitthakun
authors.affiliation: Blood Bank Unit, Chiang Mai University Hospital, Chiang Mai, Thailand.
authors.forename: Ladda
authors.initials: L
authors.lastname: Fongsatitkul
authors.affiliation: Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Sureeporn
authors.initials: S
authors.lastname: Phrompaet
mesh_terms: D000328:Adult; D001182:Arthroscopy; D064592:Autografts; D002358:Cartilage, Articular / Q000293:injuries*; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000175:diagnosis / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D018579:Patient Selection