title: A case cluster demonstrating the relationship between HLA concordance and virologic and disease outcomes in human immunodeficiency virus infection.
abstract: We present a detailed analysis of sexual HIV transmission from one source partner to two recipients. The HLA haplotypes between the source partner and one recipient were very similar with 7 out of 8 HLA alleles from four loci (HLA A, B, C and DRB) shared, while the other recipient shared only one allele. The immunologic outcomes between the two recipients differed dramatically, despite the absence of apparent virologic differences in their inoculums. We suggest that non-viral factors, which might be related to differences in the HLA profile, played a role in determining different CD4+ T-cells dynamics for these two recipients.
authors.affiliation: University of California, San Diego, La Jolla, CA, USA; Inserm UMR U966, Tours, France. Electronic address: achaillon@ucsd.edu.
authors.forename: A
authors.initials: A
authors.lastname: Chaillon
authors.affiliation: University of California, San Diego, La Jolla, CA, USA.
authors.forename: S
authors.initials: S
authors.lastname: Gianella
authors.affiliation: University of California, San Diego, La Jolla, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Massanella Luna
authors.affiliation: University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Little
authors.affiliation: University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Richman
authors.affiliation: University of California, San Diego, La Jolla, CA, USA; Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Mehta
mesh_terms: D000328:Adult; D000483:Alleles; D018450:Disease Progression; D015658:HIV Infections / Q000235:genetics / Q000276:immunology* / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D006680:HLA Antigens
keywords: Cellular immunity; Concordance; Disease progression; Evolution; HLA; Human immunodeficiency virus; Transmission