title: Facial soft-tissue morphology of adolescent patients with nonsyndromic bilateral cleft lip and palate.
abstract: The purpose of this study was to cephalometrically evaluate the facial soft-tissue characteristics of adolescent patients with bilateral cleft lip and palate (BCLP) and to compare them with a noncleft control group. Lateral cephalometric radiographs obtained from 56 adolescents with nonsyndromic BCLP (29 boys and 27 girls) were analyzed and compared with 67 control subjects (29 boys and 38 girls) who were matched for sex, age, and ethnicity. All patients had been operated on before the age of 2 years for the surgical repair of cleft lip and palate. None had received any orthopedic or orthodontic treatment. Independent-samples t test revealed that patients with BCLP significantly differed from the control group by having a flatter facial profile, thinner and more retruded nasal base, flatter nasal tip (in males), and reduced upper-lip length. Furthermore, thicker lower-lip pit, shallower mentolabial sulcus, and increased inclination angles of the upper and lower lips relative to the horizontal plane were observed in female patients compared with the normal group. The findings of the current study suggested that adolescent patients with BCLP showed several facial soft-tissue deformities when compared with normal individuals with the same age, sex, and ethnic origin. This study provides objective measures that could lead to better treatment planning and prediction of the need for corrective surgeries in patients with BCLP.
authors.affiliation: From the *Dental Material Research Center, School of Dentistry; †Sinus and Surgical Endoscopic Research Center and ‡Ghaem Hospital, School of Medicine; and §Dental Research Center, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Nadia
authors.initials: N
authors.lastname: Hasanzadeh
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Majidi
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Kianifar
authors.forename: Neda
authors.initials: N
authors.lastname: Eslami
mesh_terms: D000293:Adolescent; D059925:Anatomic Landmarks / Q000473:pathology; D001921:Brain / Q000002:abnormalities* / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D002508:Cephalometry / Q000379:methods; D002680:Chin / Q000473:pathology; D002971:Cleft Lip / Q000473:pathology* / Q000601:surgery; D002972:Cleft Palate / Q000473:pathology* / Q000601:surgery; D005145:Face / Q000473:pathology*; D005260:Female; D006801:Humans; D007492:Iran; D008046:Lip / Q000473:pathology; D008297:Male; D009666:Nose / Q000473:pathology; D012737:Sex Factors; D055815:Young Adult