title: Perineural xanthoma associated with type 2 diabetes mellitus and hyperlipidemia.
abstract: It is well known that patients with diabetes mellitus (DM) may demonstrate skin manifestations, or dermadromes, due to disease-related metabolic, vascular, neurologic, and/or immunologic disturbances; however, the pathogenesis of some of these manifestations remains unknown. Xanthomas often are associated with increased levels of serum cholesterol and/or triglycerides and therefore can present as a dermadrome in patients with a history of uncontrolled DM and hyperlipidemia. The presence of tender lesions in this patient population can indicate a diagnosis of perineural xanthoma. We report a case of perineural xanthoma arising in a patient with type 2 DM and hyperlipidemia.
authors.affiliation: Department of Dermatology, Osaka Saiseikai Izuo Hospital, Kitamura 3-4-5, Taisho-ku, Osaka 551-0032, Japan. arai88@gaia.eonet.ne.jp.
authors.forename: Rie
authors.initials: R
authors.lastname: Arai
authors.forename: Shiori
authors.initials: S
authors.lastname: Itoh
authors.forename: Asako
authors.initials: A
authors.lastname: Masatsugu
authors.forename: Miyuki
authors.initials: M
authors.lastname: Ohta
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shintaku
authors.forename: Ken
authors.initials: K
authors.lastname: Masatsugu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Horiguchi
mesh_terms: D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014973:Xanthomatosis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology
chemical_list: D014280:Triglycerides; D002784:Cholesterol