title: A Bi-Lineal Acute Leukemia (T/Myeloid, NOS) with Complex Cytogenetic Abnormalities.
abstract: We report an unusual case of bi-lineal mixed-phenotype acute leukemia (T/Myeloid, NOS) with complex cytogenetic abnormalities in a 2-year-old boy. Despite attaining complete remission with therapy, he succumbed to status epilepticus following febrile illness. Flow cytometry represents the current standard of care for the diagnosis of this malignancy and the approach adopted in our case is discussed.
authors.affiliation: Department of Haematology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India ; Department of Haematology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Prashant
authors.initials: P
authors.lastname: Sharma
authors.affiliation: Centre for Genetics, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India.
authors.forename: Meena
authors.initials: M
authors.lastname: Lall
authors.affiliation: Becton-Dickinson Biosciences, Signature Towers, Gurgaon, Haryana India.
authors.forename: Paresh
authors.initials: P
authors.lastname: Jain
authors.affiliation: Department of Haematology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Saraf
authors.affiliation: Paediatric Haemato-Oncology Division, Department of Paediatrics, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India.
authors.forename: Anupam
authors.initials: A
authors.lastname: Sachdeva
authors.affiliation: Department of Haematology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India.
authors.forename: Manorama
authors.initials: M
authors.lastname: Bhargava
keywords: Acute leukemia of ambiguous lineage; Childhood cancer; Flow cytometric immunophenotyping; Mixed-phenotype; Pediatric malignancies