title: Formal [4 + 1]-cycloaddition of homopropargyl alcohols to diazo dicarbonyl compounds giving substituted tetrahydrofurans.
abstract: A novel formal [4 + 1]-cycloaddition of readily available homopropargyl alcohols with diazo dicarbonyl compounds is described, which involves tandem O-H insertion/Conia-ene cyclization under cooperative Rh(II)/Zn(II) catalysis. This reaction provides easy access to various substituted tetrahydrofurans and exhibits complete E-selectivity in the case of nonterminal alkynes.
authors.affiliation: Graduate School of Biomedical Sciences, Nagasaki University , Nagasaki 852-8521, Japan.
authors.forename: Fumiya
authors.initials: F
authors.lastname: Urabe
authors.forename: Shohei
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Keisuke
authors.initials: K
authors.lastname: Takahashi
authors.forename: Jun
authors.initials: J
authors.lastname: Ishihara
authors.forename: Susumi
authors.initials: S
authors.lastname: Hatakeyama
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D001391:Azo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D061565:Cycloaddition Reaction; D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D010293:Pargyline / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D000438:Alcohols; D001391:Azo Compounds; D005663:Furans; D010293:Pargyline