title: Rate of improvement of CF life expectancy exceeds that of general population--observational death registration study.
abstract: BACKGROUND
  It is unclear why cystic fibrosis (CF) survival has improved. We wished to quantify increases in CF median age of death in the context of general population survival improvement.
  
  
  METHODS
  Death registration data analysis (US, England & Wales (E&W)-1972-2009).
  
  
  RESULTS
  CF median age of death is higher in US than E&W and greater for males, opposite to that of death from all causes. CF median age of death has increased by 0.543 life years per year (E&W, US combined (95% confidence interval 0.506, 0.582)). The difference in median age at death between those dying from all causes and CF decreased in both territories. CF median age of death for males is greater than for females in both territories. This gap has not narrowed.
  
  
  CONCLUSIONS
  The median age of death of people with CF is improving more rapidly than that of the general population in US and E&W.
authors.affiliation: Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, E Floor East Block, Queens Medical Centre, Nottingham, NG7 2UH, United Kingdom. Electronic address: matthew.hurley@nottingham.ac.uk.
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Hurley
authors.affiliation: Division of Epidemiology and Public Health, School of Medicine, Nottingham City Hospital, Hucknall Road, Nottingham, NG5 1PB, United Kingdom.
authors.forename: Tricia M
authors.initials: TM
authors.lastname: McKeever
authors.affiliation: Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, E Floor East Block, Queens Medical Centre, Nottingham, NG7 2UH, United Kingdom.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Prayle
authors.affiliation: Division of Epidemiology and Public Health, School of Medicine, Nottingham City Hospital, Hucknall Road, Nottingham, NG5 1PB, United Kingdom.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Fogarty
authors.affiliation: Division of Child Health, Obstetrics and Gynaecology, School of Medicine, University of Nottingham, E Floor East Block, Queens Medical Centre, Nottingham, NG7 2UH, United Kingdom.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Smyth
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D002423:Cause of Death / Q000639:trends; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000401:mortality*; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008017:Life Expectancy; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D012042:Registries; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology; D014852:Wales / Q000453:epidemiology; D055815:Young Adult
keywords: Cystic fibrosis; Healthcare; Mortality; Survival