title: Bioresorbable vascular scaffolds in acute ST-segment elevation myocardial infarction: a prospective multicentre study 'Prague 19'.
abstract: OBJECTIVE
  Bioresorbable vascular scaffolds (BVSs) have been studied in chronic coronary artery disease, but not in acute ST-segment elevation myocardial infarction (STEMI). This prospective multicentre study analysed the feasibility and safety of BVS implantation during primary percutaneous coronary intervention (p-PCI) in STEMI.
  
  
  RESULTS
  Bioresorbable vascular scaffold implantation became the default strategy for all consecutive STEMI patients between 15 December 2012 and 30 August 2013. A total of 142 patients underwent p-PCI; 41 of them (28.9%) fulfilled the inclusion/exclusion criteria for BVS implantation. The BVS device success was 98%, thrombolysis in myocardial infarction 3 flow was restored in 95% of patients, and acute scaffold recoil was 9.7%. An optical coherence tomography (OCT) substudy (21 patients) demonstrated excellent procedural results with only a 1.1% rate of scaffold strut malapposition. Edge dissections were present in a 38% of patients, but were small and clinically silent. Reference vessel diameter measured by quantitative coronary angiography was significantly lower than that measured by OCT by 0.29 (±0.56) mm, P = 0.028. Clinical outcomes were compared between BVS group and Control group; the latter was formed by patients who had implanted metallic stent and were in Killip Class I or II. Combined clinical endpoint was defined as death, myocardial infarction, or target vessel revascularization. Event-free survival was the same in both groups; 95% for BVS and 93% for Control group, P = 0.674.
  
  
  CONCLUSIONS
  Bioresorbable vascular scaffold implantation in acute STEMI is feasible and safe. The procedural results evaluated by angiography and OCT are excellent. The early clinical results are encouraging.
authors.affiliation: Cardiocenter, Third Faculty of Medicine, Charles University in Prague, University Hospital Kralovske Vinohrady, Srobarova 60, 100 34 Prague 10, Czech Republic.
authors.forename: Viktor
authors.initials: V
authors.lastname: Kočka
authors.forename: Martin
authors.initials: M
authors.lastname: Malý
authors.forename: Petr
authors.initials: P
authors.lastname: Toušek
authors.forename: Tomas
authors.initials: T
authors.lastname: Buděšínský
authors.forename: Libor
authors.initials: L
authors.lastname: Lisa
authors.forename: Petko
authors.initials: P
authors.lastname: Prodanov
authors.forename: Jiri
authors.initials: J
authors.lastname: Jarkovský
authors.forename: Petr
authors.initials: P
authors.lastname: Widimský
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D017023:Coronary Angiography; D054855:Drug-Eluting Stents; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000628:therapy*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011446:Prospective Studies; D054457:Tissue Scaffolds; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors
keywords: Acute myocardial infarction; Biodegradable stent; Bioresorbable vascular scaffold; Optical coherence tomography; Primary PCI