title: Contrasting the glial response to axon injury in the central and peripheral nervous systems.
abstract: Enabling axon regeneration after central nervous system (CNS) injury remains a major challenge in neurobiology. One of the major differences between the injured peripheral nervous system (PNS) and CNS is the pro- and antiregenerative responses of their glial cell populations. In addition to intrinsic qualities of the neurons themselves, glial-driven changes to the neural environment have a significant impact on regenerative outcome. This Review presents a comparison of the glial response to injury between the CNS and PNS and highlights features of the PNS glial response that, with continued study, might reveal long-sought-after keys to achieving CNS repair.
authors.affiliation: Department of Neurobiology, Stanford University, Stanford, CA 94110, USA. Electronic address: abrolutz@stanford.edu.
authors.forename: Amanda
authors.initials: A
authors.lastname: Brosius Lutz
authors.affiliation: Department of Neurobiology, Stanford University, Stanford, CA 94110, USA.
authors.forename: Ben A
authors.initials: BA
authors.lastname: Barres
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism / Q000502:physiology*; D002490:Central Nervous System / Q000293:injuries / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism; D009416:Nerve Regeneration; D009457:Neuroglia / Q000378:metabolism / Q000502:physiology*; D017933:Peripheral Nervous System / Q000293:injuries / Q000502:physiology*