title: Tag polymorphisms of solute carrier family 12 member 3 gene modify the risk of hypertension in northeastern Han Chinese.
abstract: Converging evidence suggests that the gene encoding solute carrier family 12 member 3 (SLC12A3) is a logical candidate involved in the underlying cause of hypertension. We therefore selected four tag polymorphisms (rs2304483, rs5804, rs8063291 and rs6499857) from SLC12A3 gene to investigate their individual and interactive associations with hypertension in northeastern Han Chinese. There were 1009 hypertensive patients and 756 normotensive controls. Data were analyzed by Haplo.Stats and multifactor dimensionality reduction (MDR) softwares, and risk estimates were expressed as odds ratio (OR) and 95% confidence interval (95% CI). Overall, there were significant differences in the genotype (P=0.002) and allele (P=0.002) distributions of rs5804 between patients and controls. Compared with the most common haplotype A-C-T-G, haplotype G-C-T-G that was overrepresented in controls (P<0.001) reduced the crude and adjusted risk of hypertension by 36% (OR 0.64; 95% CI 0.50-0.81; P<0.001) and 39% (OR 0.61; 95% CI 0.48-0.79; P<0.001), respectively. Further interaction analyses identified an overall best MDR model including rs5804 and body mass index (P=0.001), which was validated by logistic regression analysis. Taken together, our findings demonstrate a predominant role played by SLC12A3 gene rs5804 in determining hypertension risk among northeastern Han Chinese. Moreover, the interaction of this polymorphism with obesity can enhance risk prediction.
authors.affiliation: The Third Division of Cardiology, Department of Internal Medicine, The Second Affiliated Hospital of Qiqihar Medical University, Heilongjiang Province, China.
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Qi
authors.affiliation: The Third Division of Cardiology, Department of Internal Medicine, The Second Affiliated Hospital of Qiqihar Medical University, Heilongjiang Province, China.
authors.forename: J N
authors.initials: JN
authors.lastname: Bai
authors.affiliation: The Third Division of Cardiology, Department of Internal Medicine, The Second Affiliated Hospital of Qiqihar Medical University, Heilongjiang Province, China.
authors.forename: Z M
authors.initials: ZM
authors.lastname: Qi
authors.affiliation: The Third Division of Cardiology, Department of Internal Medicine, The Second Affiliated Hospital of Qiqihar Medical University, Heilongjiang Province, China.
authors.forename: J R
authors.initials: JR
authors.lastname: Li
authors.affiliation: Department of Physiology, Qiqihar Medical University, Heilongjiang, China.
authors.forename: H Y
authors.initials: HY
authors.lastname: Zhao
authors.affiliation: Department of Physiology, Qiqihar Medical University, Heilongjiang, China.
authors.forename: Y F
authors.initials: YF
authors.lastname: Wang
authors.affiliation: Department of Physiology, Qiqihar Medical University, Heilongjiang, China.
authors.forename: C Z
authors.initials: CZ
authors.lastname: Lu
authors.affiliation: Department of Physiology, Qiqihar Medical University, Heilongjiang, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: 1] Department of Hypertension, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China [2] Shanghai Institute of Hypertension, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: N
authors.initials: N
authors.lastname: Jia
authors.affiliation: Department of Physiology, Qiqihar Medical University, Heilongjiang, China.
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.affiliation: 1] Shanghai Institute of Hypertension, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China [2] State Key Laboratory of Medical Genomics, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
authors.forename: W Q
authors.initials: WQ
authors.lastname: Niu
mesh_terms: D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D064486:Solute Carrier Family 12, Member 3 / Q000235:genetics
chemical_list: C578874:SLC12A3 protein, human; D064486:Solute Carrier Family 12, Member 3