title: A RING to rule them all: RING1 as silencer and activator.
abstract: Polycomb proteins are known for silencing their target genes during development and cell differentiation. Reporting in Developmental Cell, Kondo et al. (2014) now show that Polycomb factors can also participate in gene activation by orchestrating the 3D chromatin structure changes involved in transcriptional activation of their target genes.
authors.affiliation: Institute of Human Genetics, UPR 1142 CNRS, 141 rue de la Cardonille, Montpellier, France. Electronic address: giacomo.cavalli@igh.cnrs.fr.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Cavalli
mesh_terms: D000818:Animals; D004742:Enhancer Elements, Genetic; D018398:Homeodomain Proteins / Q000378:metabolism*; D008636:Mesencephalon / Q000378:metabolism*; D063150:Polycomb Repressive Complex 1 / Q000378:metabolism*; D016548:Prosencephalon / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: D018398:Homeodomain Proteins; C102641:Mrg1 protein, mouse; D063150:Polycomb Repressive Complex 1; C489842:Rnf2 protein, mouse; D044767:Ubiquitin-Protein Ligases