title: [Metabolic effects of delta-sleep inducing peptide during physiological aging of the organism].
abstract: Subcutaneous injection of delta-sleep inducing peptide (DSIP) to postnatal rats (aged from 2 to 24 months) during 5 consecutive days every months at a dose of 10 microg/100 g body weight favors normalization of the age-related changes in carbohydrate metabolism and shows hypoglycemic effect, as manifested by a decrease in the level of glycosylated hemoglobin in erythrocytes of test rats. The administration of DSIP in postnatal rats of different age also led to a decrease in serum total lipid level, total cholesterol level, and atherogenicity index and an increase in the level of high-density lipoprotein cholesterol.
authors.forename: T I
authors.initials: TI
authors.lastname: Bondarenko
authors.forename: E A
authors.initials: EA
authors.lastname: Maĭboroda
authors.forename: I I
authors.initials: II
authors.lastname: Mikhaleva
authors.forename: I A
authors.initials: IA
authors.lastname: Prudchenko
mesh_terms: D000375:Aging / Q000097:blood*; D000818:Animals; D021461:Animals, Outbred Strains; D001786:Blood Glucose / Q000187:drug effects; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004912:Erythrocytes / Q000737:chemistry / Q000187:drug effects; D006442:Glycated Hemoglobin / Q000378:metabolism; D007279:Injections, Subcutaneous; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D051381:Rats
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D008076:Cholesterol, HDL; D003701:Delta Sleep-Inducing Peptide; D006442:Glycated Hemoglobin