title: Efficient and novel one-pot synthesis of polycycles bearing cyclols by FeCl3-promoted [2 + 2] cycloaddition: application to cannabicyclol, cannabicyclovarin, and ranhuadujuanine A.
abstract: Simple and facile synthetic routes for the preparation of biologically interesting cyclol bearing polycycles were developed using FeCl3-promoted [2 + 2] cycloaddition from readily available benzopyrans possessing a variety of substituents. As examples of this methodology, one-step syntheses of cannabicyclol, cannabicyclovarin, and ranhuadujuanine A were accomplished in good yield.
authors.affiliation: School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea. yrlee@yu.ac.kr.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Yong Rok
authors.initials: YR
authors.lastname: Lee
mesh_terms: D001578:Benzopyrans / Q000737:chemistry; D002186:Cannabinoids / Q000138:chemical synthesis*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D061565:Cycloaddition Reaction; D007501:Iron / Q000737:chemistry
chemical_list: D001578:Benzopyrans; D002186:Cannabinoids; C000591814:ranhuadujuanine A; C022213:cannabicyclol; D007501:Iron