title: [Study on the clinical manifestation of 438 cases with blepharitis].
abstract: OBJECTIVE
  To summarize the clinical characteristics and the therapy effect of blepharitis patients in clinic.
  
  
  METHODS
  Retrospective case series study.Four hundred and thirty-eight patients were diagnosed clinically as blepharitis in Beijing Tongren Hospital from Jan 2009 to July 2012. Analyzed the general states of health, case history, and the clinical manifestation, to summarize the clinical characteristics of blepharitis. The patients were clinically degree indexing and treated appropriately. After 1-2 courses of the treatment, the effect was analyzed.main outcome measures:manifestation of lid margin, corneal, conjunctiva, and the results of tear tests.
  
  
  RESULTS
  Four hundred and thirty-eight patients were recorded, from 3 to 84 years old, and the average was 40 ± 18 years old.435 (99.3%) cases were suffered with double eyes.159(26.3%) cases were males, and 279 (63.7%) cases were females. Children group had 41 cases (9.4%), which from 0 to 16 years old. Adult group (17-59 years) included 331 cases, which were 75.6% in the study. 66 cases were in aged group ( ≥ 60 years), being 15.0% in all cases.176 cases (40.2%) were on mild stage, 174 cases (39.7%) on middle stage, and 88 cases (20.1%) were on serious stage. Aged group were significantly more than children group (χ(2) = 34.575, P < 0.05).No significant difference between male and female (χ(2) = 32.877, P = 0.192). In 222 cases (50.7%) blepharitis patients complicated with correlation of keratoconjunctivitis lesions, respectively 8.5%, 75.3% and 86.4% in the mild, moderate, and severe patients. Adult group cases were significantly more than Children and aged group (χ(2) = 362.785, P < 0.05). Aged group were significantly more than Children group (χ(2) = 362.785, P < 0.05). 303 cases (69.2%)were with tear abnormal. The moderate and serious patients were more suffered with tear abnormal than mild patients (χ(2) = 64.438, P = 0.000). Patients were followed up for 1.5 to 27 months, mean 8 months. According to different extent of blepharitis, patients were given 1 courses of treatment.333 cases were clinical recovery, and the other cases were improved obviously.
  
  
  CONCLUSIONS
  Blepharitis occurs mainly in adults.It always complicate with dry eye and keratoconjunctival lesions.It is needed pay attention to by Ophthalmologist. The diagnosis and grade is based on typical clinical symptoms. The treatment according different grades should focus on the correct handling of the palpebral margin.
authors.affiliation: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100038, China. Email:sunxg1955@163.com.
authors.forename: Xu-guang
authors.initials: XG
authors.lastname: Sun
authors.forename: Yu-mei
authors.initials: YM
authors.lastname: Zhou
authors.forename: Chao
authors.initials: C
authors.lastname: Jiang
authors.forename: Zhi-qun
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001762:Blepharitis / Q000175:diagnosis* / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult