title: [Laparoscopic conservative surgery plus gonadotropin-releasing hormone agonist in the treatment of endometriosis: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the efficacy of laparoscopic conservative surgery plus gonadotropin-releasing hormone agonist (GnRH-a) in the treatment of endometriosis through meta-analysis.
  
  
  METHODS
  Six randomized controlled clinical trials comparing laparoscopic conservative surgery plus GnRH-a versus placebo or no treatment for endometriosis were retrieved. Meta-analysis was conducted to estimate the efficacy.
  
  
  RESULTS
  A total of 477 patients were included. Among them, 233 patients received laparoscopic conservative surgery plus GnRH-a while another 244 laparoscopic surgery alone. The results of meta-analysis showed that laparoscopic conservative surgery plus GnRH-a could decrease the recurrence of pain symptoms (P < 0.05), but it could not increase the pregnancy rate of infertility associated with endometriosis (P > 0.05). Furthermore the combined regiment could better improve clinical symptoms than placebo.
  
  
  CONCLUSIONS
  Laparoscopic conservative surgery plus GnRH-a could decrease the recurrence of pain symptoms associated with endometriosis, but it failed to increase the pregnancy rate of infertility.
authors.affiliation: Department of Obstetrics & Gynecology, No. 306 Hospital of PLA, Beijing 100101, China.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.affiliation: Department of Obstetrics & Gynecology, No. 306 Hospital of PLA, Beijing 100101, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.affiliation: Department of Obstetrics & Gynecology, No. 306 Hospital of PLA, Beijing 100101, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Obstetrics & Gynecology, No. 306 Hospital of PLA, Beijing 100101, China. Email: wyzhang1@yahoo.com.cn.
authors.forename: Wen-ying
authors.initials: WY
authors.lastname: Zhang
mesh_terms: D003131:Combined Modality Therapy; D004715:Endometriosis / Q000628:therapy*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D010535:Laparoscopy; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D007987:Gonadotropin-Releasing Hormone