title: Subcutaneous adipose tissue insulin resistance is associated with visceral adiposity in postmenopausal women.
abstract: OBJECTIVE
  Whole body and subcutaneous adipose tissue (SAT) insulin resistance association with regional fat mass (FM) was determined.
  
  
  METHODS
  Postmenopausal women (mean ± SD; age 56 ± 4 years, n = 25) who were overweight or obese (BMI 29.9 ± 5.1 kg/m(2) ) were studied. Whole body and regional FM were measured by dual-energy X-ray absorptiometry (DXA) and computed tomography (CT). Women were studied during basal and insulin-stimulated (3-stage euglycemic clamp) conditions. Whole-body lipolysis was assessed by [(2) H5 ]-glycerol rate of appearance and abdominal and femoral SAT lipolysis by interstitial glycerol (microdialysis).
  
  
  RESULTS
  Whole body insulin resistance in skeletal muscle (insulin-stimulated glucose disposal) and adipose tissue (insulin-suppressed lipolysis) were independently related to trunk FM (r = -0.336 and 0.484, respectively), but not leg FM (r = -0.142 and -0.148, respectively). Local antilipolytic insulin resistance in abdominal, but not femoral, SAT was positively related to trunk FM (r = 0.552) and visceral FM (r = 0.511) but not related to leg FM (r = -0.289). Whole body and abdominal, but not femoral, adipose tissue insulin sensitivity were strongly related to skeletal muscle insulin sensitivity (r = -0.727 and -0.674, respectively).
  
  
  CONCLUSIONS
  The association of SAT insulin sensitivity (lipolysis) with adiposity and skeletal muscle insulin sensitivity was specific to the abdominal region.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
authors.forename: Beret A
authors.initials: BA
authors.lastname: Casey
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Kohrt
authors.forename: Robert S
authors.initials: RS
authors.lastname: Schwartz
authors.forename: Rachael E
authors.initials: RE
authors.lastname: Van Pelt
mesh_terms: D015502:Absorptiometry, Photon; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D005260:Female; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008066:Lipolysis / Q000502:physiology; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000000981:diagnostic imaging; D056128:Obesity, Abdominal / Q000000981:diagnostic imaging / Q000378:metabolism*; D050177:Overweight / Q000000981:diagnostic imaging; D017698:Postmenopause; D012189:Retrospective Studies; D050151:Subcutaneous Fat / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
chemical_list: D007328:Insulin