title: Interaction of JAK with steroid receptor function.
abstract: The function of steroid receptors is not only regulated by steroid hormones, but also by multiple cellular signaling cascades activated by membrane-bound receptors which are stimulated by growth factors or cytokines. Cross-talk between JAK and steroid receptors plays a central role in the regulation of a multitude of physiological processes and aberrant signaling is involved in the development of numerous diseases including cancer. In this review we provide a brief summary of the knowledge of interactions between JAK and the function of steroid receptors in normal cells and tissues and in diseases.
authors.affiliation: Hematology and Oncology; University Hospital Magdeburg; Magdeburg, Germany.
authors.forename: Nibedita
authors.initials: N
authors.lastname: Gupta
authors.affiliation: Hormones and Signal Transduction Group; German Cancer Research Center; Heidelberg, Germany.
authors.forename: Doris
authors.initials: D
authors.lastname: Mayer
keywords: JAK2/estrogen receptor-alpha interaction; PPAR ligands; aldosterone; androgens; estrogens; glucocorticoids; progesterone; retinoic acid; vitamin D