title: Screening of a panel of steroid-related genes showed polymorphisms of aromatase genes confer susceptibility to advanced stage endometriosis in the Taiwanese Han population.
abstract: OBJECTIVE
  To establish a multilocus model for studying the effect of steroid-related genes on advanced stage endometriosis.
  
  
  METHODS
  A total of 121 patients with advanced stage endometriosis and 171 control women were included. Eighteen single-nucleotide polymorphisms (SNPs) from nine genes (HSD17B1, HSD17B2, HSD17B5, HSD17B6, CYP17, CYP19, ERα, ERβ, and PGR) were genotyped using the TaqMan assays. Logistic regression models were used to evaluate the genetic effects, with adjustment for other covariates.
  
  
  RESULTS
  Only the presence of the mutant CYP19 (aromatase gene) was associated with a significantly increased risk of endometriosis after adjusting for age, BMI, and parity (p = 0.002, OR = 2.69; 95% CI = 1.44-5.02). No association was ascertained between the other investigated SNPs and endometriosis.
  
  
  CONCLUSIONS
  Polymorphisms of the aromatase gene confer susceptibility to advanced stage endometriosis in the Taiwanese Han population.
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Cheng-Hsuan
authors.initials: CH
authors.lastname: Wu
authors.affiliation: Department of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Jyuer-Ger
authors.initials: JG
authors.lastname: Yang
authors.affiliation: Epidemiology and Biostatistics Center, Changhua Christian Hospital, Changhua, Taiwan.
authors.forename: Yu-Jun
authors.initials: YJ
authors.lastname: Chang
authors.affiliation: Department of Obstetrics and Gynecology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: tube2363808@gmail.com.
authors.forename: Chao-Chin
authors.initials: CC
authors.lastname: Hsu
authors.affiliation: Department of Obstetrics and Gynecology, Cheng Kung University Hospital, Tainan, Taiwan. Electronic address: paolink@mail.ncku.edu.tw.
authors.forename: Pao-Lin
authors.initials: PL
authors.lastname: Kuo
mesh_terms: D015096:3-Hydroxysteroid Dehydrogenases / Q000235:genetics; D000328:Adult; D000074425:Aldo-Keto Reductase Family 1 Member C3; D001141:Aromatase / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004715:Endometriosis / Q000208:ethnology / Q000235:genetics*; D004960:Estradiol Dehydrogenases / Q000235:genetics; D047628:Estrogen Receptor alpha / Q000235:genetics; D047629:Estrogen Receptor beta / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D019998:Racemases and Epimerases / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics; D013624:Taiwan; D055815:Young Adult
chemical_list: D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011980:Receptors, Progesterone; D015096:3-Hydroxysteroid Dehydrogenases; D006911:Hydroxyprostaglandin Dehydrogenases; C487341:AKR1C3 protein, human; D000074425:Aldo-Keto Reductase Family 1 Member C3; D004960:Estradiol Dehydrogenases; C513331:HSD17B1 protein, human; C523763:HSD17B2 protein, human; D001141:Aromatase; D013254:Steroid 17-alpha-Hydroxylase; C414602:HSD17B6 protein, human; D019998:Racemases and Epimerases
keywords: endometriosis; polymorphism; steroid-related genes