title: Multifaceted roles of adiponectin in cancer.
abstract: Obesity is linked to increased cancer risk. Pathological expansion of adipose tissue impacts adipocyte function and secretion of hormonal factors regulating tissue homeostasis and metabolism. Adiponectin is an adipocyte-secreted, circulating hormone with pleiotropic functions in lipid and glucose metabolism, and beneficial roles in cardiovascular functions and inflammation. In obesity, decreased Adiponectin plasma levels correlate with tumor development and progression. The association of Adiponectin with potential tumor-limiting functions has raised significant interest in exploring this adipokine as a target for cancer-diagnostic and therapeutic applications. Recent studies, however, also implicate Adiponectin in supporting malignancy. This review highlights the evidence that links Adiponectin signaling to either cancer-protective or cancer-supporting functions. In this context, we discuss Adiponectin interactions with its receptors and associated signaling pathways. Despite significant advances in understanding Adiponectin functions and signaling mechanisms, its role in cancer remains multifaceted and subject to controversy.
authors.affiliation: Storr Liver Unit, Westmead Millennium Institute and The University of Sydney, PO Box 412, Darcy Road, Westmead, NSW 2145, Australia. Electronic address: lionel.hebbard@sydney.edu.au.
authors.forename: Lionel
authors.initials: L
authors.lastname: Hebbard
authors.affiliation: Sanford-Burnham Medical Research Institute, NIH-designated Cancer Center, Tumor Microenvironment Program, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: ranscht@sanfordburnham.org.
authors.forename: Barbara
authors.initials: B
authors.lastname: Ranscht
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D052242:Adiponectin / Q000009:adverse effects / Q000097:blood / Q000502:physiology*; D000273:Adipose Tissue / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis; D015820:Cadherins / Q000096:biosynthesis / Q000378:metabolism; D002273:Carcinogens / Q000494:pharmacology; D004789:Enzyme Activation; D006801:Humans; D007328:Insulin / Q000502:physiology; D009369:Neoplasms / Q000209:etiology / Q000503:physiopathology*; D009389:Neovascularization, Pathologic; D054419:Receptors, Adiponectin / Q000096:biosynthesis / Q000378:metabolism; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000502:physiology; D060449:Wnt Signaling Pathway / Q000187:drug effects
chemical_list: C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D052242:Adiponectin; D014408:Biomarkers, Tumor; D015820:Cadherins; D002273:Carcinogens; C099972:H-cadherin; D007328:Insulin; D054419:Receptors, Adiponectin; D025521:Tumor Suppressor Proteins; D055372:AMP-Activated Protein Kinases
keywords: AdipoR1; AdipoR2; Adiponectin; T-cadherin; cancer; signaling