title: [Drug-induced liver damage and the problem of its pharmacological correction].
abstract: This review summarizes data on the pathogenesis and diagnostics of drug-induced liver damage. Special attention is paid to the role of individual genetically determined characteristics of drug metabolism in the development of this pathology. Results of experimental and clinical studies of the efficacy of hepatoprotectors in the treatment and prevention of the drug-induced hepatotoxicity are generalized.
authors.forename: M N
authors.initials: MN
authors.lastname: Somova
authors.forename: E N
authors.initials: EN
authors.lastname: Muzalevskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Nikolaevskiĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Buzlama
authors.forename: G A
authors.initials: GA
authors.lastname: Batishcheva
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Chernov
mesh_terms: D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D028321:Plant Preparations / Q000494:pharmacology*; D055553:Prescription Drugs / Q000009:adverse effects; D020011:Protective Agents / Q000494:pharmacology*; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D014580:Ursodeoxycholic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D015262:Xenobiotics / Q000633:toxicity
chemical_list: D028321:Plant Preparations; D055553:Prescription Drugs; D020011:Protective Agents; D015262:Xenobiotics; D014580:Ursodeoxycholic Acid; D012436:S-Adenosylmethionine