title: [Use of infusion solution remaxol in the combination treatment of patients with leptospirosis].
abstract: OBJECTIVE
  To evaluate the efficiency of using remaxol in the combination treatment of patients with leptospirosis.
  
  
  METHODS
  Thirty patients (29 men and 1 woman) with leptospirosis were treated with remaxol. The icteric and anicteric forms of the disease were diagnosed in 28 and 2 patients, respectively. Moderate, severe, and very severe leptospirosis were observed in 3, 24, and 3 cases, respectively. Remaxol was injected intravenously as a ready-to-use infusion solution 400 ml/day; the treatment duration was 3 to 9 days at the height of the disease.
  
  
  RESULTS
  Clinical improvement and normalization of laboratory parameters were achieved in the course of the disease. There were no deaths. During early convalescence at 4-5 weeks of the disease, the patients taking remaxol at the height of the disease were substantially more rarely recorded to have general weakness, fever, anorexia, myalgia, leukocytosis, increased erythrocyte sedimentation rate, and hyperbilirubinemia than those untreated with this drug.
  
  
  CONCLUSIONS
  The performed study established the clinical efficacy of remaxol when used in the combination treatment of patients with leptospirosis.
authors.forename: V V
authors.initials: VV
authors.lastname: Lebedev
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Zhuravlev
authors.forename: S V
authors.initials: SV
authors.lastname: Zotov
authors.forename: P V
authors.initials: PV
authors.lastname: Lebedev
authors.forename: M G
authors.initials: MG
authors.lastname: Pronin
authors.forename: A A
authors.initials: AA
authors.lastname: Podsadniaia
authors.forename: E K
authors.initials: EK
authors.lastname: Arbuzova
authors.forename: N V
authors.initials: NV
authors.lastname: Svistunov
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D007922:Leptospirosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013386:Succinates / Q000008:administration & dosage*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; C555877:Remaxol; D013386:Succinates