title: Further in vitro evaluation of antiradical and antimicrobial activities of phytol.
abstract: The antiradical activity of phytol was evaluated by electron paramagnetic resonance towards hydroxyl radical (·OH), superoxide anion radical (·O2(-)), methoxy radical (·CH2OH), carbon-dioxide anion radical (·CO2(-)), as well as towards nitric-oxide radical (·NO) and 2,2-diphenyl-1-picrylhydrazyl (·DPPH) radical. It reduced the production of all tested radicals showing more promising activity against ·CO2(-), ·CH2OH and ·DPPH radicals (56%, 50% and 48%, respectively) in comparison with ·NO, ·O2(-) and ·OH radicals (38%, 23% and 15%, respectively). The antimicrobial activity of phytol was evaluated by the microdilution method against eight bacterial and eight fungal strains. To varying degrees, it was proven to be active against all tested bacteria and fungi (MIC 0.003-0.038 mg/mL and MBC 0.013-0.052 mg/mL, MIC 0.008-0.016 mg/mL and MFC 0.090-0.520 mg/mL, respectively). According to the obtained results, medical foods containing phytol may support development of new therapies for heart disease.
authors.affiliation: a Department of Life Sciences , Institute for Multidisciplinary Research, University of Belgrade , Kneza Viseslava 1, Belgrade 11030 , Serbia.
authors.forename: B
authors.initials: B
authors.lastname: Pejin
authors.forename: A
authors.initials: A
authors.lastname: Savic
authors.forename: M
authors.initials: M
authors.lastname: Sokovic
authors.forename: J
authors.initials: J
authors.lastname: Glamoclija
authors.forename: A
authors.initials: A
authors.lastname: Ciric
authors.forename: M
authors.initials: M
authors.lastname: Nikolic
authors.forename: K
authors.initials: K
authors.lastname: Radotic
authors.forename: M
authors.initials: M
authors.lastname: Mojovic
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D001409:Bacillus cereus / Q000187:drug effects; D001713:Biphenyl Compounds / Q000494:pharmacology; D016972:Enterobacter cloacae / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology*; D017665:Hydroxyl Radical; D008089:Listeria monocytogenes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D009569:Nitric Oxide; D010407:Penicillium / Q000187:drug effects; D010836:Phytol / Q000494:pharmacology*; D010851:Picrates / Q000494:pharmacology; D010936:Plant Extracts; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects; D013481:Superoxides / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D013481:Superoxides; D010836:Phytol; D009569:Nitric Oxide; D017665:Hydroxyl Radical; C004931:1,1-diphenyl-2-picrylhydrazyl