title: Synthesis of novel 1,2,3-triazole tagged pyrazolo[3,4-b]pyridine derivatives and their cytotoxic activity.
abstract: A series of novel 1,2,3-triazole tagged pyrazolo[3,4-b]pyridine derivatives 3 and 4 were prepared respectively starting from 6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 1 via selective N-propargylation, followed by reaction with diverse substituted alkyl/perfluoroalkyl/aryl/aryl amide azides under Sharpless conditions. All the synthesized compounds 3 and 4 were screened for cytotoxic activity against four human cancer cell lines such as U937, THP-1, HL60 and B16-F10. Compounds 3e, 4g, 4i and 4j which showed promising activity have been identified.
authors.affiliation: Fluoro Organic Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
authors.forename: Chavva
authors.initials: C
authors.lastname: Kurumurthy
authors.affiliation: Fluoro Organic Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
authors.forename: Banda
authors.initials: B
authors.lastname: Veeraswamy
authors.affiliation: Fluoro Organic Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
authors.forename: Pillalamarri
authors.initials: P
authors.lastname: Sambasiva Rao
authors.affiliation: Fluoro Organic Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
authors.forename: Gautham
authors.initials: G
authors.lastname: Santhosh Kumar
authors.affiliation: Fluoro Organic Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India.
authors.forename: Pamulaparthy
authors.initials: P
authors.lastname: Shanthan Rao
authors.affiliation: Biology division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: Velaturu
authors.initials: V
authors.lastname: Loka Reddy
authors.affiliation: Biology division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 607, India.
authors.forename: Janapala
authors.initials: J
authors.lastname: Venkateswara Rao
authors.affiliation: Fluoro Organic Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India. Electronic address: narsaiah@iict.res.in.
authors.forename: Banda
authors.initials: B
authors.lastname: Narsaiah
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D011720:Pyrazoles; D011725:Pyridines; D014230:Triazoles; C023666:pyridine
keywords: 1,2,3-Triazoles; Cytotoxic activity; Propargylation; Pyrazolo[3,4-b]pyridine; Sharpless conditions