title: Poly(acrylic acid-co-methyl methacrylate)/metronidazole systems: synthesis and complexation.
abstract: We report on preparation of poly(acrylic acid-co-methyl methacrylate) (PAM) micro- and nanoparticles and, in the subsequent stage, complexation reaction with the active substance - metronidazole (MET). The drug release behavior of MET - loaded PAM micro- and nanoparticles was evaluated in water and phosphate buffered saline (PBS, 0.9% NaCl) at 37ºC. It has been found that introduction of MET into PAM micro- and nanoparticles enabled gradual and controlled release of the active substance. Structural analysis using FT-IR (ATR) and (1)H NMR, as well as surface morphology assessment by SEM, were performed.
authors.affiliation: Department of Chemistry and Technology of Polymers, Cracow University of Technology, Kraków, Poland.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bialik-Wąs
authors.affiliation: Department of Chemistry and Technology of Polymers, Cracow University of Technology, Kraków, Poland.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Pielichowski
mesh_terms: D016503:Drug Delivery Systems; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008795:Metronidazole / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D053758:Nanoparticles / Q000737:chemistry; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D012965:Sodium Chloride; D013499:Surface Properties; D014867:Water / Q000737:chemistry
chemical_list: D011109:Polymethacrylic Acids; C507106:poly(acrylic acid-co-methyl methacrylate); D014867:Water; D008795:Metronidazole; D012965:Sodium Chloride