title: A case of small cell carcinoma of the vagina.
abstract: Primary small cell carcinoma of the vagina is quite rare, and a standard treatment has not been established yet. Herein, we report a case of an 81-year-old woman who was diagnosed with a vaginal tumor without continuity with the uterine cervix. Histopathological diagnosis indicated alveolar solid growth of nuclear chromatin-rich atypical cells with a high N/C ratio and a partially recognized rosette-like structure, suggesting a differentiated neuroendocrine system. Chromogranin A and synaptophysin were positive. Stage I vaginal small cell carcinoma localized to the vagina was diagnosed. The tumor disappeared by radiation monotherapy with external beam irradiation and endocavitary irradiation. The patient remains alive without any disease 1 year and 8 months after the treatment, suggesting the efficacy of radiotherapy in small cell carcinoma of the vagina.
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine Japan.
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Tamura
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Yokoyama
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine Japan.
authors.forename: Asami
authors.initials: A
authors.lastname: Kobayashi
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Osawa
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine Japan.
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Shigeto
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Futagami
authors.affiliation: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Mizunuma
keywords: radiotherapy; small cell carcinoma of the vagina