title: Lymphotoxin organizes contributions to host defense and metabolic illness from innate lymphoid cells.
abstract: The lymphotoxin (LT)-pathway is a unique constituent branch of the Tumor Necrosis Superfamily (TNFSF). Use of LT is a critical mechanism by which fetal innate lymphoid cells regulate lymphoid organogenesis. Within recent years, adult innate lymphoid cells have been discovered to utilize this same pathway to regulate IL-22 and IL-23 production for host defense. Notably, genetic studies have linked polymorphisms in the genes encoding LTα to several phenotypes contributing to metabolic syndrome. The role of the LT-pathway may lay the foundation for a bridge between host immune response, microbiota, and metabolic syndrome. The contribution of the LT-pathway to innate lymphoid cell function and metabolic syndrome will be visited in this review.
authors.affiliation: Committee on Immunology, University of Chicago, United States; Department of Pathology, University of Chicago, United States.
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Upadhyay
authors.affiliation: Committee on Immunology, University of Chicago, United States; Department of Pathology, University of Chicago, United States. Electronic address: yfu@uchicago.edu.
authors.forename: Yang-Xin
authors.initials: YX
authors.lastname: Fu
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D044082:Citrobacter rodentium / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D053759:Interleukin-23 / Q000096:biosynthesis; D007378:Interleukins / Q000096:biosynthesis; D053259:Lymphotoxin beta Receptor / Q000235:genetics*; D008233:Lymphotoxin-alpha / Q000235:genetics / Q000276:immunology*; D053308:Lymphotoxin-beta / Q000235:genetics / Q000276:immunology*; D024821:Metabolic Syndrome / Q000235:genetics; D051379:Mice; D064307:Microbiota / Q000276:immunology; D052002:NF-kappa B p50 Subunit / Q000096:biosynthesis; D011110:Polymorphism, Genetic; D013601:T-Lymphocytes / Q000276:immunology; D051996:Transcription Factor RelA / Q000096:biosynthesis; D000097043:Interleukin-22
chemical_list: D053759:Interleukin-23; D007378:Interleukins; D053259:Lymphotoxin beta Receptor; D008233:Lymphotoxin-alpha; D053308:Lymphotoxin-beta; D052002:NF-kappa B p50 Subunit; D051996:Transcription Factor RelA; D000097043:Interleukin-22; C498143:RELA protein, human
keywords: Host defense; Innate lymphoid cells; Lymphotoxin; Metabolic syndrome; Microbiota