title: Hyperthermia-induced drug delivery from thermosensitive liposomes encapsulated in an injectable hydrogel for local chemotherapy.
abstract: A novel drug delivery system, enabling an in situ, thermally triggered drug release is described, consisting of an injectable thermoresponsive chitosan hydrogel containing doxorubicin-loaded thermosensitive liposomes. The design, fabrication, characterization, and an assessment of in vitro bioactivity of this formulation is detailed. Combining on-demand drug delivery with in situ gelation results in a promising candidate for local chemotherapy.
authors.affiliation: Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland (RCSI), 123 St. Stephen's Green, Dublin 2, Ireland; Trinity Centre for Bioengineering, Trinity College Dublin (TCD), Dublin 2, Ireland; Advanced Materials and Bioengineering Research (AMBER) Centre, (RCSI & TCD), Trinity College Dublin, Dublin 2, Ireland.
authors.forename: Adolfo
authors.initials: A
authors.lastname: López-Noriega
authors.forename: Conn L
authors.initials: CL
authors.lastname: Hastings
authors.forename: Burcin
authors.initials: B
authors.lastname: Ozbakir
authors.forename: Kathleen E
authors.initials: KE
authors.lastname: O'Donnell
authors.forename: Fergal J
authors.initials: FJ
authors.lastname: O'Brien
authors.forename: Gert
authors.initials: G
authors.lastname: Storm
authors.forename: Wim E
authors.initials: WE
authors.lastname: Hennink
authors.forename: Garry P
authors.initials: GP
authors.lastname: Duffy
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ruiz-Hernández
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D048271:Chitosan / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005994:Glycerophosphates / Q000737:chemistry; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D013696:Temperature
chemical_list: D005994:Glycerophosphates; D008081:Liposomes; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D004317:Doxorubicin; D048271:Chitosan
keywords: chemotherapy; chitosan hydrogels; hyperthermia; liposomes; thermoresponsive