title: Wound healing activities of standardized pomegranate rind extract and its major antioxidant ellagic acid in rat dermal wounds.
abstract: The in vivo wound healing potential of a standardized pomegranate rind extract (SPRE) and its major antioxidant constituent, ellagic acid (EA, 13 %, w/w), were investigated in three rat dermal wound models. It was found that both SPRE (5 and 2.5 %) and its equivalent amount of EA (0.65 and 0.325 %) increased the tensile strength of the incision wound by a maximum of 35.43 and 31.82 %, respectively. SPRE at 5 and 2.5 % accelerated wound contraction of the excision wound and the burn wound, while EA was effective only at 0.65 % in these two wound models. Further assays revealed that SPRE enhanced the synthesis of collagen by a maximum of 21.83 mg/g and inhibited neutrophil infiltration dose-dependently, while EA was not effective in increasing collagen accumulation and its inhibitory effect on neutrophil infiltration was milder. These results indicated that SPRE is a promising phytopharmaceutical effective in facilitating the healing of wounds and is superior to its marker compound EA.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
authors.forename: Jiao
authors.initials: J
authors.lastname: Mo
authors.forename: Pharkphoom
authors.initials: P
authors.lastname: Panichayupakaranant
authors.forename: Nattha
authors.initials: N
authors.lastname: Kaewnopparat
authors.forename: Anupong
authors.initials: A
authors.lastname: Nitiruangjaras
authors.forename: Wantana
authors.initials: W
authors.lastname: Reanmongkol
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D020405:Dermis / Q000187:drug effects / Q000473:pathology; D004610:Ellagic Acid / Q000494:pharmacology*; D029561:Lythraceae / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D004610:Ellagic Acid