title: Abnormal baseline brain activity in drug-naïve patients with Tourette syndrome: a resting-state fMRI study.
abstract: Tourette syndrome (TS) is a childhood-onset chronic disorder characterized by the presence of multiple motor and vocal tics. This study investigated spontaneous low-frequency fluctuations in TS patients during resting-state functional magnetic resonance imaging (rs-fMRI) scans. We obtained rs-fMRI scans from 17 drug-naïve TS children and 15 demographically matched healthy children. We computed the amplitude of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) of rs-fMRI data to measure spontaneous brain activity, and assessed the between-group differences in ALFF/fALFF and the relationship between ALFF/fALFF and tic severity scores. Our results showed that the children with TS exhibited significantly decreased ALFF in the posterior cingulate gyrus/precuneus and bilateral parietal gyrus. fALFF was decreased in TS children in the anterior cingulated cortex, bilateral middle and superior frontal cortices and superior parietal lobule, and increased in the left putamen and bilateral thalamus. Moreover, we found significantly positive correlations between fALFF and tic severity scores in the right thalamus. Our study provides empirical evidence for abnormal spontaneous neuronal activity in TS patients, which may implicate the underlying neurophysiological mechanism in TS and demonstrate the possibility of applying ALFF/fALFF for clinical TS studies.
authors.affiliation: Department of Pediatrics, Beijing An Ding Hospital, Capital Medical University Beijing, China.
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Medical Imaging, 306 Hospital of People's Liberation Army Beijing, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Jin
authors.affiliation: Department of Pediatrics, Beijing An Ding Hospital, Capital Medical University Beijing, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Chen
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and International Digital Group/McGovern Institute for Brain Research, Beijing Normal University Beijing, China ; Center for Collaboration and Innovation in Brain and Learning Sciences, Beijing Normal University Beijing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: He
authors.affiliation: State Key Laboratory of Cognitive Neuroscience and Learning and International Digital Group/McGovern Institute for Brain Research, Beijing Normal University Beijing, China ; Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health Baltimore, MD, USA.
authors.forename: Xia
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Pediatrics, Beijing An Ding Hospital, Capital Medical University Beijing, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zheng
keywords: Tourette syndrome; amplitude of low-frequency fluctuation; cortico-striatal-thalamo-cortical; fractional amplitude of low-frequency fluctuation; resting-state fMRI