title: Effective dose evaluation for BNCT brain tumor treatment based on voxel phantoms.
abstract: For BNCT treatments, in addition to tumor target doses, non-negligible doses will result in all the remaining organs of the body. This work aims to evaluate the effective dose as well as the average absorbed doses of each of organs of patients with brain tumor treated in the BNCT epithermal neutron beam at THOR. The effective doses were evaluated according to the definitions of ICRP Publications 60 and 103 for the reference male and female computational phantoms developed in ICRP Publication 110 by using the MCNP5 Monte Carlo code with the THOR-Y09 beam source. The effective dose acquired in this work was compared with the results of our previous work calculated for an adult hermaphrodite mathematical phantom. It was found that the effective dose for the female voxel phantom is larger than that for the male voxel phantom by a factor of 1.2-1.5 and the effective dose for the voxel phantom is larger than that for the mathematical phantom by a factor of 1.3-1.6. For a typical brain tumor BNCT, the effective dose was calculated to be 1.51Sv and the average absorbed dose for eye lenses was 1.07Gy.
authors.affiliation: Department of Engineering and System Science, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan; Division of Health Physics, Institute of Nuclear Energy Research, No. 1000, Wenhua Road, Jiaan Village, Longtan Township, Taoyuan County 32546, Taiwan.
authors.forename: Jeng-Ning
authors.initials: JN
authors.lastname: Wang
authors.affiliation: Institute of Nuclear Engineering and Science, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan; Division of Health Physics, Institute of Nuclear Energy Research, No. 1000, Wenhua Road, Jiaan Village, Longtan Township, Taoyuan County 32546, Taiwan.
authors.forename: Kuo-Wei
authors.initials: KW
authors.lastname: Lee
authors.affiliation: Department of Engineering and System Science, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan; Institute of Nuclear Engineering and Science, National Tsing Hua University, No. 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan. Electronic address: shjiang@mx.nthu.edu.tw.
authors.forename: Shiang-Huei
authors.initials: SH
authors.lastname: Jiang
mesh_terms: D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012062:Relative Biological Effectiveness; D016896:Treatment Outcome
keywords: BNCT treatment; Effective dose; MCNP5; Voxel phantom