title: Efficient and accelerated growth of multifunctional dendrimers using orthogonal thiol-ene and SN2 reactions.
abstract: An orthogonal coupling strategy was developed by combining thiol-ene and SN2 reactions, which was subsequently applied to the accelerated synthesis of multifunctional dendrimers using carbohydrate building blocks. In surface plasmon resonance (SPR) studies, the β-d-galactopyranoside-coated dendrimer exhibited nM binding affinity with the bacterial LecA lectin extracted from Pseudomonas aeruginosa.
authors.affiliation: Department of Chemistry, University of Quebec a Montreal, C.P. 8888, Succ. Centre-Ville, Montreal, Quebec, Canada H3C 3P8. roy.rene@uqam.ca.
authors.forename: Naresh
authors.initials: N
authors.lastname: Kottari
authors.forename: Yoann M
authors.initials: YM
authors.lastname: Chabre
authors.forename: Tze Chieh
authors.initials: TC
authors.lastname: Shiao
authors.forename: Rabindra
authors.initials: R
authors.lastname: Rej
authors.forename: René
authors.initials: R
authors.lastname: Roy
mesh_terms: D018829:Adhesins, Bacterial / Q000737:chemistry; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D020349:Surface Plasmon Resonance
chemical_list: D018829:Adhesins, Bacterial; D050091:Dendrimers; C102929:LecA protein, bacteria; D013438:Sulfhydryl Compounds