title: Management of comorbidities in older patients with cystic fibrosis.
abstract: Several key advances have been made in the treatment and management of people with cystic fibrosis in the past two decades. Substantial improvements in survival have resulted from the introduction of key drugs, coordinated care packages, improved nutritional support, and the intensive use of antibiotics. The age profile of people with cystic fibrosis has changed greatly during this time-some countries now have more adult than paediatric patients with the disease. With their increasing age and more advanced lung disease, several important sequelae (both pulmonary and extrapulmonary) occur in these adult patients including pulmonary disease, cystic fibrosis-related diabetes, renal disease, metabolic bone disease, cancers, drug allergies and toxic effects, and complications associated with lung transplantation.
authors.affiliation: Adult Cystic Fibrosis Centre, Department of Respiratory Medicine, Cork University Hospital, University College Cork, Cork, Ireland. Electronic address: barry.plant@hse.ie.
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Plant
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Christopher H
authors.initials: CH
authors.lastname: Goss
authors.affiliation: Department of Renal Medicine, Cork University Hospital, University College Cork, Cork, Ireland.
authors.forename: William D
authors.initials: WD
authors.lastname: Plant
authors.affiliation: Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, QLD, Australia; Queensland Children's Medical Research Institute, Royal Children's Hospital, Brisbane, QLD, Australia.
authors.forename: Scott C
authors.initials: SC
authors.lastname: Bell
mesh_terms: D000328:Adult; D017668:Age of Onset; D001851:Bone Diseases, Metabolic / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D015897:Comorbidity; D003550:Cystic Fibrosis / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D019468:Disease Management; D018450:Disease Progression; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D008171:Lung Diseases / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D016040:Lung Transplantation / Q000009:adverse effects; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D011183:Postoperative Complications / Q000453:epidemiology / Q000628:therapy*; D015995:Prevalence