title: Subfoveal choroidal thickness in retinal angiomatous proliferation.
abstract: OBJECTIVE
  To investigate the subfoveal choroidal thickness in patients with retinal angiomatous proliferation (RAP).
  
  
  METHODS
  In consecutive patients with RAP, subfoveal choroidal thickness was retrospectively measured by the use of enhanced depth imaging spectral domain optical coherence tomography in comparison with age-matched control subjects.
  
  
  RESULTS
  Nineteen eyes of 19 patients with RAP and 32 eyes of 32 control subjects were included in this study. No significant differences were found between the eyes with RAP and the control eyes regarding age, gender, spherical equivalent, and axial length. Mean subfoveal choroidal thickness in 19 eyes with RAP was significantly less than that in the control eyes (129.5 ± 35.8 μm vs. 201.3 ± 55.0 μm, P < 0.0001). The difference in mean subfoveal choroidal thickness between eyes with Stage 2 RAP (132.8 ± 38.2 μm) and eyes with Stage 3 RAP (126.4 ± 36.6 μm) was not significant, though each measurement was significantly less than that in the control eyes (P < 0.001 and P = 0.002, respectively).
  
  
  CONCLUSIONS
  Eyes with RAP had a significantly thinner subfoveal choroid compared with normal eyes. Such morphologic features may be related to the pathologic mechanism of RAP.
authors.affiliation: Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
authors.forename: Taizo
authors.initials: T
authors.lastname: Yamazaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Koizumi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamagishi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kinoshita
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002829:Choroid / Q000473:pathology*; D004396:Coloring Agents; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D009929:Organ Size; D015861:Retinal Neovascularization / Q000150:complications* / Q000175:diagnosis; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D057135:Wet Macular Degeneration / Q000150:complications* / Q000175:diagnosis
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green