title: The Complex Relationship between Liver Cancer and the Cell Cycle: A Story of Multiple Regulations.
abstract: The liver acts as a hub for metabolic reactions to keep a homeostatic balance during development and growth. The process of liver cancer development, although poorly understood, is related to different etiologic factors like toxins, alcohol, or viral infection. At the molecular level, liver cancer is characterized by a disruption of cell cycle regulation through many molecular mechanisms. In this review, we focus on the mechanisms underlying the lack of regulation of the cell cycle during liver cancer, focusing mainly on hepatocellular carcinoma (HCC). We also provide a brief summary of novel therapies connected to cell cycle regulation.
authors.affiliation: Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos#3-09, Singapore 138673, Singapore. xbisteau@imcb.a-star.edu.sg.
authors.forename: Xavier
authors.initials: X
authors.lastname: Bisteau
authors.affiliation: Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos#3-09, Singapore 138673, Singapore. mjcaldez@imcb.a-star.edu.sg.
authors.forename: Matias J
authors.initials: MJ
authors.lastname: Caldez
authors.affiliation: Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), 61 Biopolis Drive, Proteos#3-09, Singapore 138673, Singapore. kaldis@imcb.a-star.edu.sg.
authors.forename: Philipp
authors.initials: P
authors.lastname: Kaldis