title: Inhibition of reverse transcriptase and Taq DNA polymerase by compounds possessing the coumarin framework.
abstract: Coumarin derivatives were prepared using natural products isolated from plants belonging in the Pterocaulon genus (Asteraceae) and commercial drugs. Some molecules have displayed interesting activity against myeloid murine leukemia virus-reverse transcriptase (MMLV-RT) (compounds 20 and 28 produced inhibition with IC50 values of 38.62 and 50.98 μM, respectively) and Taq DNA polymerase (analogues 13 and 14 produced inhibition with IC50 values of 48.08 and 57.88 μM, respectively). Such inhibitors may have importance as antiretroviral chemotherapeutic agents and also in the development of anticancer drugs.
authors.affiliation: INTEQUI-CONICET, Fac. Qca., Bioqca. y Fcia., Univ. Nac. de San Luis (U.N.S.L), Chacabuco y Pedernera, 5700 San Luis, Argentina. Electronic address: hugocanaya@yahoo.com.ar.
authors.forename: A
authors.initials: A
authors.lastname: Garro Hugo
authors.affiliation: Área de Biología Molecular, Fac. Qca., Bioqca. y Fcia., Univ. Nac. de San Luis (U.N.S.L), Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Manzur Jimena
authors.affiliation: Instituto Multidisciplinario de Investigaciones Biológicas, IMIBIO-CONICET, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Ciuffo Gladys
authors.affiliation: INTEQUI-CONICET, Fac. Qca., Bioqca. y Fcia., Univ. Nac. de San Luis (U.N.S.L), Chacabuco y Pedernera, 5700 San Luis, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Tonn Carlos
authors.affiliation: INTEQUI-CONICET, Fac. Qca., Bioqca. y Fcia., Univ. Nac. de San Luis (U.N.S.L), Chacabuco y Pedernera, 5700 San Luis, Argentina. Electronic address: crpungi@unsl.edu.ar.
authors.forename: R
authors.initials: R
authors.lastname: Pungitore Carlos
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D020128:Inhibitory Concentration 50; D051379:Mice; D008954:Models, Biological; D015394:Molecular Structure; D008979:Moloney murine leukemia virus / Q000201:enzymology; D028321:Plant Preparations / Q000737:chemistry; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D019914:Taq Polymerase / Q000037:antagonists & inhibitors*
chemical_list: D003374:Coumarins; D028321:Plant Preparations; D018894:Reverse Transcriptase Inhibitors; C030123:coumarin; D019914:Taq Polymerase
keywords: Coumarins; Inhibition; Molecular target; Polymerase; Reverse transcriptase