title: Complete mitochondrial genome of the cephalosporin-producing fungus Acremonium chrysogenum.
abstract: Complete nucleotide sequence of the 27,266 bp mitochondrial genome of the сephalosporin C producing fungus Acremonium chrysogenum have been determined using whole genome shotgun sequencing approach. The circular mapping molecule encodes a usual set of mitochondrial proteins and RNA genes, including large and small ribosomal RNAs, 19 proteins and 26 tRNA genes and contains 2 introns. All structural genes are located on one strand and are apparently transcribed in one direction. Comparative analysis of this and previously sequenced Pezizomycotina mtDNAs revealed more extensive similarity between A. chrysogenum genome and those of Fusarium clade and specific synthenic patterns characteristic of Hypocrealean mitogenomes. Phylogenetic analysis based on catenated mitochondrial protein sequences confirmed current taxonomic position of A. chrysogenum within Hyprocreales and related taxa.
authors.affiliation: a Centre "Bioengineering" RAS , Moscow , Russia.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Eldarov
authors.affiliation: a Centre "Bioengineering" RAS , Moscow , Russia.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Mardanov
authors.affiliation: a Centre "Bioengineering" RAS , Moscow , Russia.
authors.forename: Alexey V
authors.initials: AV
authors.lastname: Beletsky
authors.affiliation: a Centre "Bioengineering" RAS , Moscow , Russia.
authors.forename: Maria V
authors.initials: MV
authors.lastname: Dumina
authors.affiliation: a Centre "Bioengineering" RAS , Moscow , Russia.
authors.forename: Nikolai V
authors.initials: NV
authors.lastname: Ravin
authors.affiliation: a Centre "Bioengineering" RAS , Moscow , Russia.
authors.forename: Konstantin G
authors.initials: KG
authors.lastname: Skryabin
mesh_terms: D000164:Acremonium / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D001482:Base Composition; D002511:Cephalosporins / Q000378:metabolism; D059646:Genome Size; D054629:Genome, Mitochondrial; D010802:Phylogeny; D017422:Sequence Analysis, DNA / Q000379:methods*
chemical_list: D002511:Cephalosporins
keywords: Acremonium chrysogenum; antibiotics; cephalosporin; fungi; mitochondrial DNA; sequence analysis