title: NIR-light-induced surface-enhanced Raman scattering for detection and photothermal/photodynamic therapy of cancer cells using methylene blue-embedded gold nanorod@SiO2 nanocomposites.
abstract: Methylene blue-loaded gold nanorod@SiO2 (MB-GNR@SiO2) core@shell nanoparticles are synthesized for use in cancer imaging and photothermal/photodynamic dual therapy. For the preparation of GNR@SiO2 nanoparticles, we found that the silica coating rate of hexadecylcetyltrimethylammonium bromide (CTAB)-capped GNRs is much slower than that of PEGylated GNRs due to the densely coated CTAB bilayer. Encapsulated MB molecules have both monomer and dimer forms that result in an increase in the photosensitizing effect through different photochemical pathways. As a consequence of the excellent plasmonic properties of GNRs at near-infrared (NIR) light, the embedded MB molecules showed NIR light-induced SERS performance with a Raman enhancement factor of 3.0 × 10(10), which is enough for the detection of a single cancer cell. Moreover, the MB-GNR@SiO2 nanoparticles exhibit a synergistic effect of photodynamic and photothermal therapies of cancer under single-wavelength NIR laser irradiation.
authors.affiliation: Department of Applied Chemistry, Kumoh National Institute of Technology, Gyeongbuk 730-701, Republic of Korea.
authors.forename: Sun-Hwa
authors.initials: SH
authors.lastname: Seo
authors.affiliation: Department of Applied Chemistry, Kumoh National Institute of Technology, Gyeongbuk 730-701, Republic of Korea.
authors.forename: Bo-Mi
authors.initials: BM
authors.lastname: Kim
authors.affiliation: Department of Applied Chemistry, Kumoh National Institute of Technology, Gyeongbuk 730-701, Republic of Korea.
authors.forename: Ara
authors.initials: A
authors.lastname: Joe
authors.affiliation: Department of Applied Chemistry, Kumoh National Institute of Technology, Gyeongbuk 730-701, Republic of Korea.
authors.forename: Hyo-Won
authors.initials: HW
authors.lastname: Han
authors.affiliation: National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
authors.forename: Xiaoyuan
authors.initials: X
authors.lastname: Chen
authors.affiliation: Molecular Imaging Program at Stanford (MIPS) and Bio-X Program, Department of Radiology, Stanford University, 1201 Welch Rd, Stanford, CA 94305, USA.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Department of Applied Chemistry, Kumoh National Institute of Technology, Gyeongbuk 730-701, Republic of Korea. Electronic address: euesoon@kumoh.ac.kr.
authors.forename: Eue-Soon
authors.initials: ES
authors.lastname: Jang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006046:Gold / Q000737:chemistry*; D007259:Infrared Rays; D051379:Mice; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry*; D010778:Photochemotherapy; D012542:Scattering, Radiation; D012822:Silicon Dioxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D006046:Gold; D012822:Silicon Dioxide
keywords: Gold nanorod; Methylene blue; Photodynamic therapy; Photothermal therapy; SERS imaging