title: High dietary fat intake during lactation promotes development of diet-induced obesity in male offspring of mice.
abstract: The maternal nutritional status during pregnancy and lactation influences the risk of obesity in offspring, but the details of this phenomenon are unclear. In particular, there is little information on the influence on the offspring of the maternal nutritional status during lactation only. Therefore, in this study, we examined the influence of high dietary fat intake in dams during lactation on the risk of obesity in offspring, using C57BL/6J mice. The mice were fed a control diet (CD) during pregnancy. After birth, dams were fed a CD or a high-fat diet (HD) during lactation (3 wk). Fat and energy were significantly increased in milk from dams fed a HD during lactation. Male offspring were weaned at 3 wk old and fed a CD for 4 wk, which resulted in no significant difference in their physique. Four weeks after weaning, the offspring (7 wk old) were fed a CD or HD for 4 wk to induce obesity. High dietary fat intake in dams and offspring promoted lipid accumulation in white adipose tissue and adipocyte hypertrophy in male offspring. The underlying mechanism may involve an increase in expression of Lpl and a decrease in expression of Hsl in white adipose tissue of offspring. In conclusion, our results show that high dietary fat intake during lactation promotes development of diet-induced obesity in male offspring.
authors.affiliation: Laboratory of Food and Biomolecular Science, Graduate School of Agriculture Science, Tohoku University.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tsuduki
authors.forename: Yasuna
authors.initials: Y
authors.lastname: Kitano
authors.forename: Taro
authors.initials: T
authors.lastname: Honma
authors.forename: Ryo
authors.initials: R
authors.lastname: Kijima
authors.forename: Ikuo
authors.initials: I
authors.lastname: Ikeda
mesh_terms: D052436:Adipose Tissue, White / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001522:Behavior, Animal; D059305:Diet, High-Fat / Q000009:adverse effects*; D002149:Energy Intake; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006984:Hypertrophy; D007774:Lactation; D050356:Lipid Metabolism; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D051379:Mice; D008810:Mice, Inbred C57BL; D008892:Milk / Q000737:chemistry; D009765:Obesity / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002787:Sterol Esterase / Q000235:genetics / Q000378:metabolism; D014886:Weaning
chemical_list: D002787:Sterol Esterase; D008071:Lipoprotein Lipase