title: Bortezomib therapy for nephrotic syndrome due to idiopathic membranous nephropathy.
abstract: Idiopathic membranous nephropathy is a common cause of nephrotic syndrome in adults. The nephrotic syndrome due to idiopathic membranous nephropathy is often resistant to glucocorticosteroids and requires an alkylating agent such as chlorambucil or cyclophosphamide to induce remission. Recent studies illustrate that antibodies against the autoantigen M-type phospholipase A2 receptor contribute to a vast majority but not all cases of idiopathic membranous nephropathy. Herein, we report a patient with nephrotic syndrome due to membranous nephropathy that was resistant to 6 months of therapy with ramipril and high-dose glucocorticosteroids but responded to a single cycle of bortezomib infusion.
authors.affiliation: The Rogosin Institute, 505 East 70th Street, Box 102, New York, NY, 10021, USA, chh2001@nyp.org.
authors.forename: Choli
authors.initials: C
authors.lastname: Hartono
authors.forename: Miriam
authors.initials: M
authors.lastname: Chung
authors.forename: Sheng F
authors.initials: SF
authors.lastname: Kuo
authors.forename: Surya V
authors.initials: SV
authors.lastname: Seshan
authors.forename: Thangamani
authors.initials: T
authors.lastname: Muthukumar
mesh_terms: D001897:Boronic Acids / Q000627:therapeutic use*; D000069286:Bortezomib; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000209:etiology; D061988:Proteasome Inhibitors / Q000627:therapeutic use*; D011719:Pyrazines / Q000627:therapeutic use*
chemical_list: D001897:Boronic Acids; D061988:Proteasome Inhibitors; D011719:Pyrazines; D000069286:Bortezomib