title: The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice.
abstract: Experimental autoimmune encephalomyelitis (EAE) is a model for human multiple sclerosis (MS) in rodents. Static magnetic field (SMF)-exposure was shown to be beneficial in specific cases of inflammatory background, where it suppresses symptoms. The null-hypothesis was that animals with induced EAE exposed to SMF would show different seriousness of symptoms, than those in the sham-exposed control group. Three replicated series of repetitive, 30 min/day whole-body exposure to SMF with 477 mT peak-to-peak magnetic induction and 48 T/m lateral induction gradient was tested on female CSJLF1 mice with a mild, mouse spinal cord homogenate emulsion-induced EAE. Conventional scores of the animal response to EAE were compared between sham- and SMF-exposed groups of animals. Following pilot test we used 18 animals per group. Primary outcome measure was the daily group average of standard EAE scores. Results show that SMF-exposure has a strong, reproducible, and significantly beneficial effect up to 51.82% (p<0.001) over sham-exposure on the symptoms of EAE in the course of the 25 days of the experiment. This study aimed to build experimental research foundation for a later therapy option by applying SMF-exposure in the clinical management of MS.
authors.forename: János F
authors.initials: JF
authors.lastname: László
authors.forename: Judit
authors.initials: J
authors.lastname: Solténszky
authors.forename: Róbert
authors.initials: R
authors.lastname: Pórszász
authors.forename: Attila
authors.initials: A
authors.lastname: Kónya
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D005620:Freund's Adjuvant / Q000494:pharmacology; D060526:Magnetic Fields; D051379:Mice; D010243:Paralysis / Q000503:physiopathology / Q000628:therapy; D013116:Spinal Cord / Q000503:physiopathology
chemical_list: D000276:Adjuvants, Immunologic; D005620:Freund's Adjuvant