title: Targeting platelet receptor function in thrombus formation: the risk of bleeding.
abstract: In this review, we presume that the process of thrombus formation, as assessed in whole blood flow studies and in experimental (murine) thrombosis studies, reflects the platelet responses in human haemostasis and thrombosis. Following this concept, we give an up-to-date overview of the main platelet receptors and signalling pathways that contribute to thrombus formation and are used as targets in (pre)clinical intervention studies to prevent cardiovascular disease. Discussed are receptors for thrombin, thromboxane, ADP, ATP, prostaglandins, von Willebrand factor, collagen, CLEC-2 ligand, fibrinogen and laminin. Sketched are the consequences of receptor deficiency or blockage for haemostasis and thrombosis in mouse and man. Recording of bleeding due to (congenital) platelet dysfunction or (acquired) antiplatelet treatment occurs according to different protocols, while common laboratory methods are used to determine platelet function.
authors.affiliation: Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands.
authors.forename: Frauke
authors.initials: F
authors.lastname: Swieringa
authors.affiliation: Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands.
authors.forename: Marijke J E
authors.initials: MJ
authors.lastname: Kuijpers
authors.affiliation: Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands. Electronic address: jwm.heemskerk@maastrichtuniversity.nl.
authors.forename: Johan W M
authors.initials: JW
authors.lastname: Heemskerk
authors.affiliation: Department of Biochemistry, CARIM, Maastricht University, Maastricht, The Netherlands.
authors.forename: Paola E J
authors.initials: PE
authors.lastname: van der Meijden
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D006470:Hemorrhage / Q000209:etiology / Q000378:metabolism; D006801:Humans; D051379:Mice; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors*; D013927:Thrombosis / Q000378:metabolism* / Q000517:prevention & control
chemical_list: D011956:Receptors, Cell Surface
keywords: Antiplatelet drugs; Bleeding; Cardiovascular disease; Platelets; Thrombus