title: Regulating intestinal function to reduce atherogenic lipoproteins.
abstract: Significant knowledge regarding different molecules involved in the transport of dietary fat into the circulation has been garnered. Studies point to the possibility that accumulation of intestine-derived lipoproteins in the plasma could contribute to atherosclerosis. This article provides a brief overview of dietary lipid metabolism and studies in mice supporting the hypothesis that intestinal lipoproteins contribute to atherosclerosis. Deficiencies in lipoprotein lipase and Gpihbp1, and overexpression of heparanse in mice, are associated with increases in atherosclerosis, suggesting that defects in catabolism of larger lipoproteins in the plasma contribute to atherosclerosis. Furthermore, inositol-requiring enzyme 1β-deficient mice that produce more intestinal lipoproteins also develop more atherosclerosis. Thus, increases in plasma intestinal lipoproteins due to either overproduction or reduced catabolism result in augmented atherosclerosis. Intestinal lipoproteins tend to adhere strongly to subendothelial proteoglycans, elicit an inflammatory response by endothelial cells and activate macrophages, contributing to the initiation and progression of the disease. Thus, molecules that reduce intestinal lipid absorption can be useful in lowering atherosclerosis.
authors.affiliation: Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11797, USA ; Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11797, USA.
authors.forename: M Mahmood
authors.initials: MM
authors.lastname: Hussain
authors.affiliation: Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11797, USA ; Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11797, USA.
authors.forename: Tung Ming
authors.initials: TM
authors.lastname: Leung
authors.affiliation: Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11797, USA ; Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11797, USA.
authors.forename: Liye
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Department of Cell Biology, SUNY Downstate Medical Center, Brooklyn, NY 11797, USA ; Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY 11797, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Abu-Merhi
keywords: MTP; apoB; atherosclerosis; cholesterol; chylomicronemia; hyperlipidemia; hypertriglyceridemia; lipoproteins; triglyceride