title: Cucurbit[7]uril assisted ultraviolet to visible fluorescence switch of a heart medicine.
abstract: Host-guest interactions between cucurbit[7]uril (CB7) and a cardiotonic drug, milrinone, have been explored using steady state and pico-second time-resolved techniques. A novel fluorescence switch from ultraviolet (UV) to visible (cyan) is observed as a consequence of upward pKa shift of the drug inside the nano-cavity of cucurbit[7]uril.
authors.affiliation: Department of Chemistry, Mendeleev Block, Indian Institute of Science Education and Research, Pune, India. p.hazra@iiserpune.ac.in.
authors.forename: Krishna
authors.initials: K
authors.lastname: Gavvala
authors.forename: Raj Kumar
authors.initials: RK
authors.lastname: Koninti
authors.forename: Abhigyan
authors.initials: A
authors.lastname: Sengupta
authors.forename: Partha
authors.initials: P
authors.lastname: Hazra
mesh_terms: D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002316:Cardiotonic Agents / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D020105:Milrinone / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D013050:Spectrometry, Fluorescence; D014466:Ultraviolet Rays; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D002316:Cardiotonic Agents; D007093:Imidazoles; D020105:Milrinone; C456276:cucurbit(7)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils