title: [Alterations of SP-A, SP-D and KL-6 in serum and bronchoalveolar lavage fluid in children with Mycoplasma pneumoniae pneumonia].
abstract: OBJECTIVE
  To study the alterations and relationship of surfactant protein (SP)-A, SP-D and KL-6 in serum and bronchoalveolar lavage fluids (BALF) in children with Mycoplasma pneumoniae pneumonia (MPP).
  
  
  METHODS
  Self-control method was used for the study on SP-A, SP-D and KL-6 in serum, infected and non-infected BALFs in 32 MMP children with only one side of MPP.
  
  
  RESULTS
  The contents of SP-A, SP-D and KL-6 in infected BALF were [mg/L;M (IQR) ]: 243 (90-468) , 187 (43-333) , 148 (47-426) ;104 (37-257) , 56 (25-131) , 35 (12-147) in non-infected BALF; 35 (25-69) , 33 (9-149) and 24 (15-62) in serum. The correlation coefficient of KL-6 between serum and infected BALF were -0.534 and -0.378 (P < 0.05).
  
  
  CONCLUSIONS
  There were significant correlation between the alterations of SP-A, SP-D and KL-6 in serum and lung infection in children with CAP. KL-6 in serum may be more sensitive than SP-A and SP-D.
authors.affiliation: Division of Pediatric Pulmonology, Shengjing Hospital of China Medical University, Shenyang 110004, China. Email: shulinhua@126.com.
authors.forename: Lin-hua
authors.initials: LH
authors.lastname: Shu
authors.forename: Yun-xiao
authors.initials: YX
authors.lastname: Shang
authors.forename: Xu-xu
authors.initials: XX
authors.lastname: Cai
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Zong
authors.forename: Xiao-na
authors.initials: XN
authors.lastname: Meng
authors.forename: Han
authors.initials: H
authors.lastname: Zhang
authors.forename: Zhi-jia
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Dai
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D018396:Mucin-1 / Q000097:blood / Q000378:metabolism*; D011019:Pneumonia, Mycoplasma / Q000097:blood / Q000378:metabolism*; D037662:Pulmonary Surfactant-Associated Protein A / Q000097:blood / Q000378:metabolism*; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood / Q000378:metabolism*; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C060192:MUC1 protein, human; D018396:Mucin-1; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D