title: The Impact of Left Ventricular Hypertrophy and Diastolic Dysfunction on Outcome in Intracerebral Hemorrhage Patients.
abstract: BACKGROUND
  The objective of this study was to determine the prevalence of LVH and DD in patients presenting with supratentorial deep ICH and to determine if the presence of LVH or DD was an independent predictor of initial ICH volume, hematoma expansion, or poor outcome.
  
  
  METHODS
  A cross-sectional study was performed on ICH patients who presented from 7/2008 to 12/2010. Cases were excluded if ICH was traumatic, lobar, infratentorial, secondary to elevated international normalized ratio, suspicious for underlying structural malformation, or where surgical evacuation was performed. Logistic and linear regressions were used to assess the ability of LVH to predict ICH imaging characteristics and patient outcomes.
  
  
  RESULTS
  After adjusting for use of hemostatic agents, LVH was not a significant independent predictor of initial ICH volume (P= 0.344) or 33% volume expansion (P= 0.378). After adjusting for age, infectious complications, and use of hemostatic agents, LVH was not a significant independent predictor of poor functional outcome (P= 0.778). Similar results were seen for DD.
  
  
  CONCLUSIONS
  In our sample, patients with deep ICH and LVH were more likely to develop IVH, but LVH was not a significant independent predictor of initial ICH volume, hematoma expansion, or poor short-term outcome.
authors.affiliation: Health Services and Outcomes Research Center for Outcome and Effectiveness Research and Education (COERE), University of Alabama at Birmingham, Birmingham, AL 35294-4410, USA ; Center of Excellence in Comparative Effectiveness Research for Eliminating Disparities (CERED) Minority Health & Health Disparities Research Center (MHRC), University of Alabama at Birmingham, Birmingham, AL 35294-4410, USA ; School of Public Health, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.
authors.forename: Karen C
authors.initials: KC
authors.lastname: Albright
authors.affiliation: Department of Medicine, Cardiology Section, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Burak
authors.affiliation: Division of Neurosciences Critical Care Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
authors.forename: Tiffany R
authors.initials: TR
authors.lastname: Chang
authors.affiliation: Stroke Program, Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors.forename: Aimee
authors.initials: A
authors.lastname: Aysenne
authors.affiliation: Stroke Program, Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors.forename: James E
authors.initials: JE
authors.lastname: Siegler
authors.affiliation: Stroke Program, Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors.forename: Laurie
authors.initials: L
authors.lastname: Schluter
authors.affiliation: Department of Neurology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA.
authors.forename: Sharyl R
authors.initials: SR
authors.lastname: Martini
authors.affiliation: School of Public Health, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294-0022, USA.
authors.forename: Amelia K
authors.initials: AK
authors.lastname: Boehme
authors.affiliation: Stroke Program, Department of Neurology, Tulane University School of Medicine, New Orleans, LA 70112, USA ; Stroke Program at Tulane University Hospital, Department of Neurology, Suite 1000, 1440 Canal Street, TB-52, New Orleans, LA 70112-2715, USA.
authors.forename: Sheryl
authors.initials: S
authors.lastname: Martin-Schild