title: Targeted therapies for bone sarcomas.
abstract: Bone sarcomas include a very large number of tumour subtypes, which originate form bone and more particularly from mesenchymal stem cell lineage. Osteosarcoma, Ewing's sarcoma and chondrosarcoma, the three main bone sarcoma entities develop in a favourable microenvironment composed by bone cells, blood vessels, immune cells, based on the 'seed and soil theory'. Current therapy associates surgery and chemotherapy, however, bone sarcomas remain diseases with high morbidity and mortality especially in children and adolescents. In the past decade, various new therapeutic approaches emerged and target the tumour niche or/and directly the tumour cells by acting on signalling/metabolic pathways involved in cell proliferation, apoptosis or drug resistance. The present review gives a brief overview from basic to clinical assessment of the main targeted therapies of bone sarcoma cells.
authors.affiliation: INSERM, UMR 957, Faculty of Medicine, University of Nantes , Nantes, France ; Faculté de Médecine, Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives , Nantes, France ; University Hospital, Hôtel Dieu , CHU de Nantes, France ; Equipe Labellisée Ligue Nationale Contre le Cancer 2012 , Nantes, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Heymann
authors.affiliation: INSERM, UMR 957, Faculty of Medicine, University of Nantes , Nantes, France ; Faculté de Médecine, Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives , Nantes, France ; University Hospital, Hôtel Dieu , CHU de Nantes, France ; Equipe Labellisée Ligue Nationale Contre le Cancer 2012 , Nantes, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Rédini