title: The relationship between epicardial adipose tissue and ST-segment resolution in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
abstract: The relationship between epicardial adipose tissue (EAT) and coronary artery disease has been predominantly demonstrated in the last two decades. The aim of this study was to investigate the predictive value of EAT thickness on ST-segment resolution that reflects myocardial reperfusion in patients undergoing primary percutaneous coronary intervention (pPCI) for acute ST-segment elevation myocardial infarction (STEMI). The present study prospectively included 114 consecutive patients (mean age 54 ± 10 years, range 35-83, 15 women) with first acute STEMI who underwent successful pPCI. ST-segment resolution (ΔSTR) <70 % was accepted as ECG sign of no-reflow phenomenon. The EAT thickness was measured by two-dimensional echocardiography. EAT thickness was increased in patients with no-reflow (3.9 ± 1.7 vs. 5.4 ± 2, p = 0.001). EAT thickness was also found to be inversely correlated with ΔSTR (r = -0.414, p = 0.001). Multivariate logistic regression analysis demonstrated that EAT thickness independently predicted no-reflow (OR 1.43, 95 % CI 1.13-1.82, p = 0.003). Receiver operating characteristic curve analysis demonstrated good diagnostic accuracy for EAT thickness in predicting no-reflow [area under curve (AUC) = 0.72, 95 % CI 0.63-0.82, p < 0.001]. In conclusion, increased EAT thickness may play an important role in the prediction of no-reflow in STEMI treated with pPCI.
authors.affiliation: Department of Cardiology, Acibadem Maslak Hospital, Buyukdere C. 40 Maslak/Sarıyer, 34457, Istanbul, Turkey, ertuzencirci@gmail.com.
authors.forename: Ertuğrul
authors.initials: E
authors.lastname: Zencirci
authors.forename: Aycan Esen
authors.initials: AE
authors.lastname: Zencirci
authors.forename: Aleks
authors.initials: A
authors.lastname: Değirmencioğlu
authors.forename: Gültekin
authors.initials: G
authors.lastname: Karakuş
authors.forename: Murat
authors.initials: M
authors.lastname: Uğurlucan
authors.forename: Kıvılcım
authors.initials: K
authors.lastname: Özden
authors.forename: Aysun
authors.initials: A
authors.lastname: Erdem
authors.forename: Ahmet Ümit
authors.initials: AÜ
authors.lastname: Güllü
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ekmekçi
authors.forename: Yalçın
authors.initials: Y
authors.lastname: Velibey
authors.forename: Hatice Betül
authors.initials: HB
authors.lastname: Erer
authors.forename: Seden
authors.initials: S
authors.lastname: Çelik
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akyol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D016009:Chi-Square Distribution; D004562:Electrocardiography; D005260:Female; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000175:diagnosis / Q000628:therapy*; D054318:No-Reflow Phenomenon / Q000175:diagnosis / Q000209:etiology*; D016017:Odds Ratio; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D010496:Pericardium / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012307:Risk Factors; D016896:Treatment Outcome; D014463:Ultrasonography