title: [Multivariate analysis of risk factors for intra-abdominal infections after radical gastrectomy for gastric cancer].
abstract: OBJECTIVE
  To explore the major risk factors for intra-abdominal infections after radical gastrectomy in patients with gastric cancer.
  
  
  METHODS
  From October 2010 to January 2013, a total of 479 patients undergoing radical gastrectomy at Department of Gastric, Duodenal & Pancreatic Surgery, Hunan Provincial Tumor Hospital were divided into 2 groups according to an onset of postoperative intra-abdominal infections (n = 32, 6.68%) or not (n = 447, 93.32%). Their clinicopathological data, such as age, gender, co-morbidities, surgical duration, operative blood loss and pathological stage were retrospectively analyzed by Logistic regressive analysis with a case-control study model.
  
  
  RESULTS
  As compared with the control group, the patients had a greater age ((59 ± 10) vs (53 ± 11) years, P < 0.01), lower lymphocyte count ((1.4 ± 0.7) ×10(9)/L vs (1.7 ± 0.6) ×10(9)/L, P = 0.02), lower hemoglobin level ( (108 ± 28) vs (117 ± 24) g/L, P = 0.04), lower albumin level ((34 ± 6) vs (37 ± 5) g/L, P < 0.01) and longer surgical duration ((244 ± 43) vs (216 ± 45) min, P < 0.01) in the postoperative intra-abdominal infection group. Univariate Logistic regressive analysis found that a history of abdominal surgery, body mass index (BMI) >25 kg/m(2), co-morbidities, diabetes mellitus, complications due to gastric cancer, lymphocyte count <1.5×10(9)/L, hemoglobin <100 g/L, albumin <30 g/L, ascites, perioperative transfusion, total mastectomy, combined organ resection and surgical duration >240 min were associated with the occurrence of postoperative intra-abdominal infections (all P < 0.05). Further multivariate analysis identified 4 independent risk factors for intra-abdominal infections after radical gastrectomy, including combined multiorgan resection (OR = 3.64, 95%CI: 1.39-9.55), BMI>25 kg/m(2) (OR = 3.04, 95%CI: 1.17-7.92), diabetes mellitus (OR = 3.41, 95%CI: 1.05-11.09) and perioperative transfusion (OR = 2.24, 95%CI: 1.02-5.13).
  
  
  CONCLUSIONS
  A correction of modifiable risk factors may reduce the incidence of intra-abdominal infections after radical gastrectomy, shorten the length of hospital stays and improve outcomes in patients with gastric cancer.
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China.
authors.forename: Yong-zhong
authors.initials: YZ
authors.lastname: Ouyang
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Tang
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tang
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China.
authors.forename: Shu-guang
authors.initials: SG
authors.lastname: Pan
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Yin
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Luo
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China.
authors.forename: Hu
authors.initials: H
authors.lastname: Quan
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China.
authors.forename: Xiao-xin
authors.initials: XX
authors.lastname: Qiu
authors.affiliation: Department of Gastric, Duodenal & Pancreatic Surgery, Affiliated Tumor Hospital, Xiangya Medical School, Central South University, Changsha 410013, China. Email: zuochaohui@vip.sina.com.
authors.forename: Chao-hui
authors.initials: CH
authors.lastname: Zuo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects*; D006801:Humans; D059413:Intraabdominal Infections / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000150:complications* / Q000601:surgery; D055815:Young Adult