title: [Platform for drug discovery targeting HMGB1, AGEs-RAGE response].
authors.forename: Shuji
authors.initials: S
authors.lastname: Mori
authors.forename: Hideo
authors.initials: H
authors.lastname: Takahashi
authors.forename: Takao
authors.initials: T
authors.lastname: Toyomura
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D048909:Diabetes Complications / Q000235:genetics / Q000628:therapy; D055808:Drug Discovery / Q000639:trends; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D024243:HMGB1 Protein / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000628:therapy; D018836:Inflammation Mediators / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008019:Life Style; D008024:Ligands; D020782:Matrix Metalloproteinases / Q000378:metabolism; D058990:Molecular Targeted Therapy; D016328:NF-kappa B / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D010766:Phosphorylation; D017382:Reactive Oxygen Species / Q000378:metabolism; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000502:physiology*
chemical_list: D016207:Cytokines; D024243:HMGB1 Protein; D018836:Inflammation Mediators; D008024:Ligands; D016328:NF-kappa B; D017382:Reactive Oxygen Species; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D018799:Intercellular Adhesion Molecule-1; D048049:Extracellular Signal-Regulated MAP Kinases; D020782:Matrix Metalloproteinases; D019204:GTP-Binding Proteins