title: [Effects of chrysalis oil on learning, memory and oxidative stress in D-galactose-induced ageing model of mice].
abstract: To investigate the effects of chrysalis oil on learning, memory and oxidative stress in D-galactose-induced ageing model of mice.
  
  
  
  Mice were injected intraperitoneally with D-galactose daily and received chrysalis oil intragastrically simultaneously for 30 d. Then mice underwent space navigation test and spatial probe test, superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) activity and malondialdehyde (MDA) contents in mouse brain were measured.
  
  
  
  Compared to model group, escape latency in mice treated with 6 ml/kg*d chrysalis oil was significantly shorter (P<0.05), crossing times in 12 ml/kg*d group and 6 ml/kg*d group treated with chrysalis oil were significantly increased (P<0.05). Chrysalis oil treatment (12ml/kg*d) significantly increased SOD and GSH-PX activity and reduced MDA contents in brain of D-galactose-induced aging mice.
  
  
  
  Chrysalis oil can improve the ability of learning and memory in D-galactose-induced aging mice, and inhibit peroxidation in brain tissue.
authors.affiliation: Zhejiang University City College, School of Medicine, Hangzhou 310015, China.
authors.forename: Weiping
authors.initials: W
authors.lastname: Chen
authors.forename: Qiongjie
authors.initials: Q
authors.lastname: Yang
authors.forename: Xing
authors.initials: X
authors.lastname: Wei
mesh_terms: D000375:Aging; D000818:Animals; D012831:Bombyx / Q000737:chemistry*; D005690:Galactose / Q000633:toxicity*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D018384:Oxidative Stress / Q000187:drug effects*
chemical_list: D005690:Galactose