title: Tranexamic acid overdosage-induced generalized seizure in renal failure.
abstract: We report a 45-year-old lady with chronic kidney disease stage 4 due to chronic tubulointerstial disease. She was admitted to our center for severe anemia due to menorrhagia and deterioration of renal function. She was infused three units of packed cells during a session of hemodialysis. Tranexamic acid (TNA) 1 g 8-hourly was administered to her to control bleeding per vaginum. Two hours after the sixth dose of TNA, she had an episode of generalized tonic clonic convulsions. TNA was discontinued. Investigations of the patient revealed no biochemical or structural central nervous system abnormalities that could have provoked the convulsions. She did not require any further dialytic support. She had no further episodes of convulsion till dis-charge and during the two months of follow-up. Thus, the precipitating cause of convulsions was believed to be an overdose of TNA.
authors.forename: Anil
authors.initials: A
authors.lastname: Bhat
authors.affiliation: Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Dipankar M
authors.initials: DM
authors.lastname: Bhowmik
authors.forename: Deepti
authors.initials: D
authors.lastname: Vibha
authors.forename: Manu
authors.initials: M
authors.lastname: Dogra
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Agarwal
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D000933:Antifibrinolytic Agents / Q000009:adverse effects* / Q000378:metabolism; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000503:physiopathology; D008595:Menorrhagia / Q000175:diagnosis / Q000188:drug therapy*; D008875:Middle Aged; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D014148:Tranexamic Acid / Q000009:adverse effects* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid