title: Requisites for successful theranostics with radionuclide-based reporter gene imaging.
abstract: Radionuclide-based theranostic strategy has been widely used in diagnosis and treatment of patients with hyperthyroidism or differentiated thyroid cancer for a long time, and sodium iodide symporter gene is the radionuclide-based reporter gene used in theranostics. Theranostics, which is a promising approach, offering the ideal combination of accurate diagnosis and successful therapy in various clinical fields, is expected to become a key area of personalized medicine. Rapid advancements in biotechnologies using theranostic reporter genes and theranostic radiochemistry have led to development of the concept of theranostics using radionuclide-based imaging reporter genes; the theranostic approach is almost ready for application in a limited arena of clinics. In order to fulfill both the diagnostic and therapeutic purposes, theranostics with radionuclide-based imaging reporter requires use of successful combinations of various components, such as radionuclide-based reporter genes, promoters/enhancers that regulate expression of reporter genes, delivery vectors/vehicles, imaging or therapeutic probes and prodrugs, transductional and transcriptional targeting strategies, transgene amplification systems, etc. In this review, overview and recent updates on theranostics using radionuclide-based imaging reporter genes will be discussed.
authors.affiliation: Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital , Daegu , Republic of Korea.
authors.forename: Byeong-Cheol
authors.initials: BC
authors.lastname: Ahn
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques; D017930:Genes, Reporter; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging / Q000235:genetics / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D057054:Molecular Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D027981:Symporters / Q000235:genetics; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000235:genetics / Q000532:radiotherapy; D015899:Tomography, Emission-Computed, Single-Photon; D000099209:Sodium-Iodide Symporters
chemical_list: D019275:Radiopharmaceuticals; D027981:Symporters; D000099209:Sodium-Iodide Symporters