title: Two- and three-dimensional prenatal sonographic diagnosis of Alagille syndrome.
abstract: We describe a case of Alagille syndrome diagnosed by second-trimester ultrasound. Features included the characteristic prominent chin, single umbilical artery, and hemivertebrae. Three-dimensional imaging demonstrated classic butterfly vertebrae, which were not otherwise appreciable. Alagille syndrome may be detected by second-trimester ultrasound in the at-risk fetus.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, ME, 04102.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Wax
authors.forename: Renée
authors.initials: R
authors.lastname: Chard
authors.forename: Michael G
authors.initials: MG
authors.lastname: Pinette
authors.forename: Angelina
authors.initials: A
authors.lastname: Cartin
mesh_terms: D000328:Adult; D016738:Alagille Syndrome / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007231:Infant, Newborn; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal / Q000379:methods*; D055815:Young Adult
keywords: Alagille syndrome; butterfly vertebrae; fetal malformations; hemivertebrae; intrahepatic cholestasis; obstetrics; ultrasonography