title: Anaphylactic Shock: Kounis Hypersensitivity-Associated Syndrome Seems to be the Primary Cause.
abstract: Experiments have shown that anaphylaxis decreases cardiac output; increases left ventricular end diastolic pressure; induces severe early acute increase in respiratory resistance with pulmonary interstitial edema; and decreases splanchnic, cerebral, and myocardial blood flow more than what would be expected from severe arterial dilation and hypotension. This is attributed to the constrictive action of inflammatory mediators released during anaphylactic shock. Inflammatory mediators such as histamine, neutral proteases, arachidonic acid products, platelet-activating factor (PAF), and a variety of cytokines and chemokines constitute the pathophysiologic basis of Kounis hypersensitivity-associated acute coronary syndrome. Although the mechanisms of anaphylactic shock still remain to be elucidated, myocardial involvement due to vasospasm-induced coronary blood flow reduction manifesting as Kounis syndrome should be always considered. Searching current experimental and clinical literature on anaphylactic shock pathophysiology, causality, clinical appearance, and treatment via PubMed showed that differentiating global hypoperfusion from primary tissue suppression due to mast cell mediator constrictive action on systemic arterial vasculature is a challenging procedure. Combined tissue suppression from arterial involvement and peripheral vasodilatation, perhaps, occur simultaneously. In cases of anaphylactic shock treatment targeting the primary cause of anaphylaxis together with protection of coronary vasculature and subsequently the cardiac tissue seems to be of paramount importance.
authors.affiliation: Department of Medical Sciences, Patras Highest Institute of Education and Technology, Patras, Greece.
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Kounis
authors.affiliation: Department of Cardiology, 'Saint Andrews' State General Hospital, Patras, Greece.
authors.forename: George D
authors.initials: GD
authors.lastname: Soufras
authors.affiliation: Department of Cardiology, University of Patras Medical School, Rio, Patras, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Hahalis
keywords: Anaphylactic shock; Anaphylaxis; Kounis syndrome; Respiratory reactance; Respiratory resistance; Vascular resistance