title: Tracking of stem cells in vivo for cardiovascular applications.
abstract: In the past ten years, the concept of injecting stem and progenitor cells to assist with rebuilding damaged blood vessels and myocardial tissue after injury in the heart and peripheral vasculature has moved from bench to bedside. Non-invasive imaging can not only provide a means to assess cardiac repair and, thereby, cellular therapy efficacy but also a means to confirm cell delivery and engraftment after administration. In this first of a two-part review, we will review the different types of cellular labeling techniques and the application of these techniques in cardiovascular magnetic resonance and ultrasound. In addition, we provide a synopsis of the cardiac cellular clinical trials that have been performed to-date.
authors.forename: Nicole
authors.initials: N
authors.lastname: Azene
authors.forename: Yingli
authors.initials: Y
authors.lastname: Fu
authors.forename: Jeremy
authors.initials: J
authors.lastname: Maurer
authors.affiliation: Russell H, Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, USA. dkraitc1@jhmi.edu.
authors.forename: Dara L
authors.initials: DL
authors.lastname: Kraitchman
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D058948:Cell Tracking / Q000379:methods; D006801:Humans; D008279:Magnetic Resonance Imaging; D015336:Molecular Probe Techniques; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012038:Regeneration; D033581:Stem Cell Transplantation; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome