title: Effectiveness of an Indian-made attenuated influenza A(H1N1)pdm 2009 vaccine: a case control study.
abstract: A live attenuated influenza A(H1N1)pdm 2009 vaccine was developed and distributed in India in 2010. We estimated the vaccine effectiveness (VE) against laboratory-confirmed pandemic H1N1 (pH1N1) infections in patients with influenza-like illness who visited five tertiary care hospitals in Pune, India during June-December 2010. Swab specimens were analyzed for influenza pH1N1 by reverse transcriptase polymerase chain reaction (RT-PCR). VE was estimated using the test-negative case-control study design and logistic regression. A total of 784 patients (253 cases, 531 controls) were analyzed. The unadjusted overall VE was 75.5% (95% confidence interval [CI] 42.1-89.7), while the adjusted VE was 76% (95% CI 42.1-89.7). We conclude that the live attenuated influenza A(H1N1)pdm 2009 vaccine was effective in our study population, which has opened prospects for using this platform for trivalent formulations.
authors.affiliation: Serum Institute of India Ltd; Pune, India.
authors.forename: Prasad S
authors.initials: PS
authors.lastname: Kulkarni
authors.affiliation: D Y Patil Medical College; Pune, India.
authors.forename: Sharad
authors.initials: S
authors.lastname: Agarkhedkar
authors.affiliation: Bharti Vidyapeeth Medical College; Pune, India.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Lalwani
authors.affiliation: King Edward Memorial Hospital Research Centre; Pune, India.
authors.forename: Ashish R
authors.initials: AR
authors.lastname: Bavdekar
authors.affiliation: Deenanath Mangeshkar Hospital and Research Centre; Pune, India.
authors.forename: Sameer
authors.initials: S
authors.lastname: Jog
authors.affiliation: Nobel Hospital; Pune, India.
authors.forename: Sidram K
authors.initials: SK
authors.lastname: Raut
authors.affiliation: Diagnosearch Limited; Mumbai, India.
authors.forename: Varsha
authors.initials: V
authors.lastname: Parulekar
authors.affiliation: D Y Patil Medical College; Pune, India.
authors.forename: Shalaka S
authors.initials: SS
authors.lastname: Agarkhedkar
authors.affiliation: Bharti Vidyapeeth Medical College; Pune, India.
authors.forename: Sonali
authors.initials: S
authors.lastname: Palkar
authors.affiliation: Serum Institute of India Ltd; Pune, India.
authors.forename: Somnath
authors.initials: S
authors.lastname: Mangrule
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology* / Q000302:isolation & purification; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000302:isolation & purification; D012189:Retrospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016896:Treatment Outcome; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D055815:Young Adult
chemical_list: D007252:Influenza Vaccines; D012367:RNA, Viral; D014613:Vaccines, Attenuated
keywords: case control; effectiveness; influenza A(H1N1)pdm 2009; live attenuated vaccine; pandemic