title: [Value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography in early diagnosis of lung cancer].
abstract: OBJECTIVE
  To evaluate the application value of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) in early diagnosis of lung cancer.
  
  
  METHODS
  Retrospective analyses were conducted for 347 cases of pulmonary space-occupying lesions at Zhongshan Hospital from June 2010 to October 2012. The diagnostic validity of PET/CT and fluorodeoxyglucose maximum standardized uptake value (SUVmax) of lesions were compared respectively. Among different morphological characteristics, pathologic types and levels of tumor markers. The diagnostic value of PET/CT was also evaluated along with serum tumor markers for lung cancer.
  
  
  RESULTS
  SUVmax was positively correlated with lesion size (r = 0.484, P < 0.05) and negatively with tumor differentiation degree (r = -0.232, P < 0.01). It was significantly higher in tumor marker positive group than the negative group (10.6 ± 5.5 vs 7.6 ± 5.4, P < 0.05). The diagnostic specificity, sensitivity and accuracy of PET/CT were 50.0%, 96.6% and 89.3% in lung cancer. And the greater the lesion, the higher the diagnostic accuracy (P < 0.05). PET/CT plus serum tumor markers could boost the diagnostic specificity of lung cancer by 30% (P < 0.01).
  
  
  CONCLUSIONS
  (18)F-FDG PET/CT has high diagnostic values for early stage pulmonary nodules. It can also suggest the differentiation degree of lung cancer. Combined use of serum tumor markers and (18)F-FDG PET/CT increases the early diagnostic specificity of lung cancer.
authors.affiliation: Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai Respiratory Research Institute, Shanghai 200032, China.
authors.forename: Fang-lei
authors.initials: FL
authors.lastname: Liu
authors.forename: Qun-ying
authors.initials: QY
authors.lastname: Hong
authors.forename: Hong-cheng
authors.initials: HC
authors.lastname: Shi
authors.forename: Yu-can
authors.initials: YC
authors.lastname: Gu
authors.affiliation: Email: chunxue.bai@zs-hospital.sh.cn.
authors.forename: Chun-xue
authors.initials: CX
authors.lastname: Bai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood; D055088:Early Detection of Cancer; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000000981:diagnostic imaging*; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D019788:Fluorodeoxyglucose F18