title: Leptomeningeal carcinomatosis from breast cancer treated with intrathecal topotecan with concomitant intravenous eribulin.
abstract: We present a patient with leptomeningeal carcinomatosis from breast cancer treated with intrathecal topotecan and intravenous eribulin. The regimen was well tolerated and provided clinical stability in a patient with progression on a prior intrathecal chemotherapy regimen.
authors.affiliation: Boston University, Boston, MA, USA.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Salgia
authors.affiliation: University of Chicago, Department of Medicine, Section of Hematology & Oncology, Chicago, IL, USA.
authors.forename: Gini F
authors.initials: GF
authors.lastname: Fleming
authors.affiliation: University of Chicago, Department of Neurology, 5841 South Maryland Avenue, MC 2030, Chicago, IL 60637, USA. Electronic address: rlukas@neurology.bsd.uchicago.edu.
authors.forename: Rimas V
authors.initials: RV
authors.lastname: Lukas
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000473:pathology*; D005260:Female; D005663:Furans / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D007659:Ketones / Q000008:administration & dosage*; D055756:Meningeal Carcinomatosis / Q000188:drug therapy* / Q000556:secondary*; D008875:Middle Aged; D019772:Topotecan / Q000008:administration & dosage*; D000095662:Polyether Polyketides
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D007659:Ketones; D019772:Topotecan; C490954:eribulin; D000095662:Polyether Polyketides
keywords: Breast neoplasms; Eribulin; Intrathecal; Meningeal carcinomatosis; Topotecan