title: De novo design of Ln(III) coiled coils for imaging applications.
abstract: A new peptide sequence (MB1) has been designed which, in the presence of a trivalent lanthanide ion, has been programmed to self-assemble to form a three stranded metallo-coiled coil, Ln(III)(MB1)3. The binding site has been incorporated into the hydrophobic core using natural amino acids, restricting water access to the lanthanide. The resulting terbium coiled coil displays luminescent properties consistent with a lack of first coordination sphere water molecules. Despite this the gadolinium coiled coil, the first to be reported, displays promising magnetic resonance contrast capabilities.
authors.affiliation: School of Chemistry and ‡School of Biosciences, University of Birmingham , Edgbaston, B15 2TT, United Kingdom.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Berwick
authors.forename: David J
authors.initials: DJ
authors.lastname: Lewis
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Jones
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Parslow
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Dafforn
authors.forename: Helen J
authors.initials: HJ
authors.lastname: Cooper
authors.forename: John
authors.initials: J
authors.lastname: Wilkie
authors.forename: Zoe
authors.initials: Z
authors.lastname: Pikramenou
authors.forename: Melanie M
authors.initials: MM
authors.lastname: Britton
authors.forename: Anna F A
authors.initials: AF
authors.lastname: Peacock
mesh_terms: D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D049449:Luminescence; D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D010455:Peptides