title: Role of adiponectin in mediating the association of osteocalcin with insulin resistance and type 2 diabetes: a cross sectional study in pre- and post-menopausal women.
abstract: OBJECTIVE
  To analyse the association of osteocalcin with insulin resistance and type 2 diabetes and assess the role of adiponectin in these relationships.
  
  
  METHODS
  This study comprised 98 newly diagnosed type 2 diabetic women (51 pre-menopausal and 47 post-menopausal) and 102 age and BMI matched controls (53 pre-menopausal and 49 post-menopausal). Insulin resistance was calculated by homeostasis model assessment-insulin resistance (HOMA-IR).
  
  
  RESULTS
  Osteocalcin was significantly positively correlated with adiponectin in both pre-menopausal (p = 0.0026) and post-menopausal diabetic women (p = 0.0357). Significant negative association between osteocalcin and HOMA-IR was observed only in pre-menopausal diabetic women (p = 0.0019), but the association was partially reduced (p = 0.0219) after additional adjustment for adiponectin. Adiponectin slightly attenuated the inverse association between osteocalcin and presence of type 2 diabetes in both pre- and post-menopausal women.
  
  
  CONCLUSIONS
  The protective action of osteocalcin against the development of insulin resistance and type 2 diabetes in women may be partially mediated through up-regulation of adiponectin secretion.
authors.affiliation: Department of Biochemistry, NSCB Medical College , Jabalpur, Madhya Pradesh , India .
authors.forename: Anil Baran
authors.initials: AB
authors.lastname: Choudhury
authors.forename: Purnima Dey
authors.initials: PD
authors.lastname: Sarkar
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Sakalley
authors.forename: Sudhakar B
authors.initials: SB
authors.lastname: Petkar
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D015675:Osteocalcin / Q000378:metabolism*; D017698:Postmenopause / Q000378:metabolism*; D017697:Premenopause / Q000378:metabolism*
chemical_list: D052242:Adiponectin; D015675:Osteocalcin