title: Case of solitary pulmonary capillary hemangioma: pathological features based on frozen section analysis.
abstract: Solitary pulmonary capillary hemangioma (SPCH) is a rare benign lung tumor that must be distinguished from small and early lung cancers. Here, we report a case of SPCH for which we performed frozen section diagnosis. The patient was a 55-year-old Japanese woman. Five years before the operation, mixed ground-glass opacity was detected by computed tomography in the left posterior basal segment of the lower lobe (S10). Because the interior tumor density of the ground-glass opacity increased slightly, video-assisted thoracic surgery wedge resection was performed. Frozen section diagnosis revealed a benign tumor without proliferation of atypical epithelial cells. The tumor had narrow alveolar lumens, thickened alveolar septa and a clear boundary separating it from normal lung tissue. The proliferated lumens varied in size and were lined with single layers of flat cells. After the operation, immunohistochemical staining of a paraffin section revealed that the thickened alveolar septa resulted from the proliferation of capillary vessels, the flat cells of which were positive for CD31 and CD34 and negative for podoplanin; the tumor was diagnosed as SPCH. Here, we discuss the pathological features of SPCH on frozen sections with reference to this case and review previous related reports.
authors.affiliation: Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan; Department of Thoracic Surgery, Kanagawa Cancer Center, Yokohama, Japan; Department of Surgery, Yokohama City University, Yokohama, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Isaka
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yokose
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ito
authors.forename: Kota
authors.initials: K
authors.lastname: Washimi
authors.forename: Naoko
authors.initials: N
authors.lastname: Imamura
authors.forename: Masato
authors.initials: M
authors.lastname: Watanabe
authors.forename: Kentaro
authors.initials: K
authors.lastname: Imai
authors.forename: Teppei
authors.initials: T
authors.lastname: Nishii
authors.forename: Kouzo
authors.initials: K
authors.lastname: Yamada
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Nakayama
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
mesh_terms: D005260:Female; D005629:Frozen Sections; D018324:Hemangioma, Capillary / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008875:Middle Aged
keywords: CD31; CD34; Elastica van Gieson; frozen section; frozen section diagnosis; ground-glass opacity; immunohistochemical staining; podoplanin; solitary pulmonary capillary hemangioma