title: Breaching the blood-brain barrier for drug delivery.
abstract: Molecular "hitchhiking" through receptor-mediated transcytosis at the blood-brain barrier is a CNS drug delivery strategy. In this issue of Neuron, Niewoehner et al. (2014) describe a modular anti-transferrin receptor Fab approach for shuttling therapeutic antibodies into the brain.
authors.affiliation: Neuroscience Research Unit, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA 02139, USA.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Bell
authors.affiliation: Neuroscience Research Unit, Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, MA 02139, USA. Electronic address: michael.ehlers@pfizer.com.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Ehlers
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D006801:Humans; D021381:Protein Transport / Q000502:physiology*; D057127:Single-Chain Antibodies / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D057127:Single-Chain Antibodies