title: Optic neuropathy secondary to Linezolid for multidrug-resistant mycobacterial spinal tuberculosis.
abstract: OBJECTIVE
  To report a case of optic neuropathy secondary to Linezolid, second line anti tuberculosis agent.
  
  
  METHODS
  22 year Indian male with multidrug resistant spinal tuberculosis and TB meningitis was started on second line anti tuberculosis drugs. Within one month of onset of second line anti TB drug, he was noted to have optic neuropathy in both eyes. Visual field and electro diagnostics suggested optic neuropathy.
  
  
  CONCLUSIONS
  Linezolid is a synthetic oxazolidinone broad spectrum antibiotic and has been in off label use for multidrug resistant tuberculosis (MDR-TB). There are very scattered case reports of optic neuropathy secondary to use of this off label drug. In our case, the optic neuropathy was however reversible on stoppage of the drug.
  
  
  CONCLUSIONS
  It seems prudent that baseline ophthalmological evaluation to be done for all patients to be subjected for treatment with this drug for any short term or long term therapy.
authors.affiliation: Moorfields Eye Hospital NHS Foundation Trust , London , UK and.
authors.forename: Rupesh
authors.initials: R
authors.lastname: Agrawal
authors.forename: Peter
authors.initials: P
authors.lastname: Addison
authors.forename: Zubin
authors.initials: Z
authors.lastname: Saihan
authors.forename: Maria
authors.initials: M
authors.lastname: Pefkianaki
authors.forename: Carlos
authors.initials: C
authors.lastname: Pavesio
mesh_terms: D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D000069349:Linezolid; D008297:Male; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy*; D014399:Tuberculosis, Spinal / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid
keywords: Linezolid; MDR TB; optic neuropathy; second-line anti-TB drugs