title: Antioxidant status and oxidative stress in the circulation of younger and elderly human subjects.
abstract: Extensive research has demonstrated the protective properties of antioxidants, which scavenge reactive oxygen species and their precursors, as well as up-regulate enzymes involved in the repair of cellular damage. Several case-control studies have showed higher blood levels of antioxidants and decreased oxidative stress in younger individuals when compared with older ones. Cell damage caused by free radicals appears to be a major contributor in aging and degenerative diseases of aging such as cancer, cardiovascular disease, cataracts, compromised immune system, rheumatoid arthritis and brain dysfunction. The objective of this study was to determine the variation of Circulating levels of selected antioxidants (enzymic and non enzymic) and oxidative stress marker in younger and older humans. The results showed that a majority of the younger age group participants showed a significant increase in enzymic and nonenzymic antioxidant status and a decrease in oxidative stress when compared with the older age group.
authors.affiliation: Department of Medical Biochemistry, School of Health Sciences, Kannur University, Thalassery, Kerala India.
authors.forename: P
authors.initials: P
authors.lastname: Faizal
authors.affiliation: Department of Surgical Oncology, Malabar Cancer Centre, Thalassery, Kerala India.
authors.forename: B
authors.initials: B
authors.lastname: Satheeshan
authors.affiliation: Department of Radiation Oncology, Malabar Cancer Centre, Thalassery, Kerala India.
authors.lastname: Milindkumar
authors.affiliation: Department of Medical Biochemistry, School of Health Sciences, Kannur University, Thalassery, Kerala India.
authors.forename: A K
authors.initials: AK
authors.lastname: Adarsh
authors.affiliation: Department of Medical Biochemistry, School of Health Sciences, Kannur University, Thalassery, Kerala India.
authors.forename: R
authors.initials: R
authors.lastname: Shilpa
authors.affiliation: Department of Medical Biochemistry, School of Health Sciences, Kannur University, Thalassery, Kerala India.
authors.forename: P
authors.initials: P
authors.lastname: Roshni
authors.affiliation: Department of Medical Biochemistry, School of Health Sciences, Kannur University, Thalassery, Kerala India.
authors.forename: T
authors.initials: T
authors.lastname: Remya
authors.affiliation: Department of Medical Biochemistry, School of Health Sciences, Kannur University, Thalassery, Kerala India ; Research Guide in Medical Biochemistry, School of Health Sciences, Kannur University, Palayad (PO), Kannur, Thalassery, 670 661 Kerala India ; Kunnathedam, R1- Jai Nagar, Medical College P.O, Thiruvananthapuram, 695 011 Kerala India.
authors.forename: K T
authors.initials: KT
authors.lastname: Augusti
keywords: Antioxidants; Free radicals; Oxidative stress; Reactive oxygen species