title: Characterization of the congeners in the lantibiotic NAI-107 complex.
abstract: NAI-107, a lantibiotic produced by Microbispora sp. 107891, shows potent activity against multi-drug-resistant bacterial pathogens. It is produced as a complex of related molecules, which is unusual for ribosomally synthesized peptides. Here we describe the identification, characterization, and antibacterial activity of the congeners produced by Microbispora sp. 107891 and by the related Microbispora corallina NRRL 30420. These molecules differ by the presence of two, one, or zero hydroxyl groups at Pro-14, by the presence of a chlorine at Trp-4, and/or by the presence of a sulfoxide on the thioether of the first lanthionine.
authors.affiliation: NAICONS , Via Gaudenzio Fantoli 16/15, 20138, Milano, Italy.
authors.forename: Sonia I
authors.initials: SI
authors.lastname: Maffioli
authors.forename: Marianna
authors.initials: M
authors.lastname: Iorio
authors.forename: Margherita
authors.initials: M
authors.lastname: Sosio
authors.forename: Paolo
authors.initials: P
authors.lastname: Monciardini
authors.forename: Eleonora
authors.initials: E
authors.lastname: Gaspari
authors.forename: Stefano
authors.initials: S
authors.lastname: Donadio
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000409:Alanine / Q000031:analogs & derivatives; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001430:Bacteriocins / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D015394:Molecular Structure; D005810:Multigene Family; D013440:Sulfides
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D013440:Sulfides; C528150:microbisporicin; C001520:lanthionine; D000409:Alanine