title: Circadian disruption in the pathogenesis of metabolic syndrome.
abstract: Metabolic syndrome is a multifactorial process induced by a combination of genetic and environmental factors and recent evidence has highlighted that circadian disruption and sleep loss contribute to disease pathogenesis. Emerging work in experimental genetic models has provided insight into the mechanistic basis for clock disruption in disease. Indeed, disruption of the clock system perturbs both neuroendocrine pathways within the hypothalamus important in feeding and energetics, in addition to peripheral tissues involved in glucose and lipid metabolism. This review illustrates the impact of molecular clock disruptions at the level of both brain and behavior and peripheral tissues, with a focus on how such dysregulation in turn impacts lipid and glucose homeostasis, inflammation and cardiovascular function. New insight into circadian biology may ultimately lead to improved therapeutics for metabolic syndrome and cardiovascular disease in humans.
authors.affiliation: Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Lurie 7-220, Chicago, Illinois 60611, USA. Electronic address: e-maury@northwestern.edu.
authors.forename: E
authors.initials: E
authors.lastname: Maury
authors.affiliation: Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Lurie 7-220, Chicago, Illinois 60611, USA.
authors.forename: H K
authors.initials: HK
authors.lastname: Hong
authors.affiliation: Department of Medicine, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Lurie 7-220, Chicago, Illinois 60611, USA. Electronic address: j-bass@northwestern.edu.
authors.forename: J
authors.initials: J
authors.lastname: Bass
mesh_terms: D056926:CLOCK Proteins / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology*; D002940:Circadian Rhythm; D004734:Energy Metabolism; D005786:Gene Expression Regulation; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000378:metabolism / Q000503:physiopathology*; D015398:Signal Transduction; D012892:Sleep Deprivation / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D008055:Lipids; D056926:CLOCK Proteins; D005947:Glucose
keywords: Cardiovascular disease; Circadian rhythm; Metabolism