title: [Clinicopathologic characteristics of sporadic renal hemangioblastoma].
abstract: OBJECTIVE
  To investigate the clinicopathological characteristics of sporadic renal hemangioblastoma.
  
  
  METHODS
  Two cases of sporadic renal hemangioblastoma were studied by histological and immunohistochemical staining, along with review of the literature.
  
  
  RESULTS
  Both cases were presented with a renal mass during annual physical examination with an age of 40 and 45 years, respectively. The lesions located in the middle portion of the kidney with a sharp tumor border. Histopathologically, the tumors were characterized by two major components: capillary and stromal cells. Immunohistochemically, the stromal cells were positive for vimentin, NSE, S-100 protein and inhibin-α, and negative for CK, HMB45, Melan A, EMA, CD56 and syn. Both tumors showed a very low level of Ki-67 labeling. The endothelial cells were positive for CD34.
  
  
  CONCLUSIONS
  Sporadic renal hemangioblastoma is a rare benign neoplasm, the diagnosis of which is based on the characteristic follicular architecture and an exclusion of other carcinomas of the kidney.
authors.affiliation: Department of Pathology, Affiliated Hospital of Jining Medical University, Jining 272029, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Pathology,Jining First People's Hospital, Jining 272011, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Li-hua
authors.initials: LH
authors.lastname: Zhao
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Lin-sheng
authors.initials: LS
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Department of Pathology, Affiliated Hospital of Jining Medical University, Jining 272029, China; E-mail: hzzhang_1964@163.com.
authors.forename: Ren-ya
authors.initials: RY
authors.lastname: Zhang
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000378:metabolism / Q000473:pathology; D018952:Antigens, CD34 / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D018325:Hemangioblastoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000378:metabolism; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D014057:Tomography, X-Ray Computed / Q000379:methods; D014746:Vimentin / Q000378:metabolism
chemical_list: D018952:Antigens, CD34; D009418:S100 Proteins; D014746:Vimentin; C094377:inhibin-alpha subunit; D007265:Inhibins; D010751:Phosphopyruvate Hydratase