title: Young coronary artery disease in patients undergoing percutaneous coronary intervention.
abstract: OBJECTIVE
  Understanding the nature and pattern of young coronary artery disease (CAD) is important due to the tremendous impact on these patients' socio-economic and physical aspect. Data on young CAD in the southeast Asian region is rather patchy and limited. Hence we utilized our National Cardiovascular Disease Database (NCVD)-Percutaneous Coronary Intervention (PCI) Registry to analyze young patients who underwent PCI in the year 2007 to 2009.
  
  
  METHODS
  This is a retrospective study of all patients who had undergone coronary angioplasty from 2007 to 2009 in 11 hospitals across Malaysia.
  
  
  METHODS
  Data were obtained from the NCVD-PCI Registry, 2007 to 2009. Patients were categorized into 2 groups-young and old, where young was defined as less than 45 years for men and less than 55 years for women and old was defined as more than or equals to 45 years for men and more than or equals to 55 years for women. Patients' baseline characteristics, risk factor profile, extent of coronary disease and outcome on dis.charge, and 30-day and 1-year follow-up were compared between the 2 groups.
  
  
  RESULTS
  We analyzed 10268 patients, and the prevalence of young CAD was 16% (1595 patients). There was a significantly low prevalence of Chinese patients compared to other major ethnic groups. Active smoking (30.2% vs 17.7%) and obesity (20.9% vs 17.3%) were the 2 risk factors more associated with young CAD. There is a preponderance toward single vessel disease in the young CAD group, and they had a favorable clinical outcome in terms of all-cause mortality at discharge (RR 0.49 [CI 0.26-0.94]) and 1-year follow-up (RR 0.47 [CI 0.19-1.15]).
  
  
  CONCLUSIONS
  We observed distinctive features of young CAD that would serve as a framework in the primary and secondary prevention of the early onset CAD.
authors.affiliation: Dr. AS Zuhdi, Cardiology Unit,, University Malaya Medical Centre,, Lembah Pantai,, Kuala Lumpur 59 100, Malaysia, T: +603.79494422, F: +603-79562253, syadizuhdi@yahoo.co.uk.
authors.forename: A S
authors.initials: AS
authors.lastname: Zuhdi
authors.forename: Jeevitha
authors.initials: J
authors.lastname: Mariapun
authors.forename: Noran Naqiah
authors.initials: NN
authors.lastname: Mohd Hairi
authors.forename: Wan Azman
authors.initials: WA
authors.lastname: Wan Ahmad
authors.forename: Imran Zainal
authors.initials: IZ
authors.lastname: Abidin
authors.forename: Abdul Wahab
authors.initials: AW
authors.lastname: Undok
authors.forename: Muhammad Dzafir
authors.initials: MD
authors.lastname: Ismail
authors.forename: Kui-hian
authors.initials: KH
authors.lastname: Sim
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D003324:Coronary Artery Disease / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D016208:Databases, Factual; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects