title: Findings of cardiac magnetic resonance imaging in asymptomatic myocardial ischemic disease in Takayasu arteritis.
abstract: Takayasu arteritis (TA) may affect myocardium and cause coronary stenosis. The aim of this study was to assess the prevalence and pattern of myocardial disease in patients with TA, using late gadolinium enhancement (LGE) of cardiac magnetic resonance imaging (CMRI). Twenty-seven consecutive patients with TA and 80 age- and gender-matched controls without known cardiovascular disease underwent CMRI. The prevalence of myocardial ischemic disease, as revealed by LGE, was compared between patients with TA and controls, and factors associated with myocardial disease were identified in patients with TA. Myocardial ischemic disease, as characterized by LGE on CMRI, was present in 7 (25.9%) of 27 patients with TA, and imaging with LGE showed a typical pattern of myocardial infarction in 6 patients (22.2%). Although both patients with TA and control subjects shared a similar risk of cardiovascular events, the prevalence of myocardial ischemia was >5× greater in patients with TA (p = 0.002 vs controls). No association was found between myocardial disease in patients with TA and cardiovascular atherosclerotic risk factors. The presence of myocardial scarring tended to be more closely associated with specific features of TA such as renovascular hypertension, older age at the onset of TA symptoms, male gender, aneurysmal dilatation, and Numano type V. In conclusion, finding of a significant and unexpectedly high prevalence of occult myocardial scarring in patients with TA indicates the usefulness of CMRI with LGE for the identification of occult myocardial disease in such patients.
authors.affiliation: Department of Internal Medicine 2, Centre de Référence des Maladies Autoimmunes Rares, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Cloé
authors.initials: C
authors.lastname: Comarmond
authors.affiliation: Department of Cardiovascular Imaging and Interventional Radiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Cluzel
authors.affiliation: Department of Cardiovascular Imaging and Interventional Radiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Dan
authors.initials: D
authors.lastname: Toledano
authors.affiliation: Department of Internal Medicine 2, Centre de Référence des Maladies Autoimmunes Rares, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Costedoat-Chalumeau
authors.affiliation: Department of Cardiology, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Richard
authors.initials: R
authors.lastname: Isnard
authors.affiliation: Department of Vascular Surgery, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Gaudric
authors.affiliation: Department of Vascular Surgery, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Chiche
authors.affiliation: Department of Vascular Surgery, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Koskas
authors.affiliation: Department of Internal Medicine 2, Centre de Référence des Maladies Autoimmunes Rares, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France.
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
authors.affiliation: Department of Internal Medicine 2, Centre de Référence des Maladies Autoimmunes Rares, Assistance Publique-Hôpitaux de Paris (AP-HP), Groupe Hospitalier Pitié Salpétrière, Université Pierre et Marie Curie, Paris, France. Electronic address: david.saadoun@psl.aphp.fr.
authors.forename: David
authors.initials: D
authors.lastname: Saadoun
mesh_terms: D000328:Adult; D058070:Asymptomatic Diseases / Q000453:epidemiology*; D002921:Cicatrix / Q000473:pathology; D005260:Female; D005682:Gadolinium; D006801:Humans; D006978:Hypertension, Renovascular / Q000453:epidemiology; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D015995:Prevalence; D018570:Risk Assessment; D013625:Takayasu Arteritis / Q000453:epidemiology*
chemical_list: D005682:Gadolinium