title: Rhamnogalacturonan from Acmella oleracea (L.) R.K. Jansen: gastroprotective and ulcer healing properties in rats.
abstract: A rhamnogalacturonan (RGal) isolated from Acmella oleracea (L.) R.K. Jansen administered by oral route showed gastroprotective activity against acute lesions induced by ethanol. In this study, we investigated the gastric ulcer healing effect of RGal and its mechanisms of action. Intraperitoneal treatment of animals with RGal protected the gastric mucosa against acute lesions induced by ethanol, with participation of gastric mucus. Furthermore, in the chronic ulcer model, oral administration of RGal accelerates the gastric ulcer healing, accompanied by increasing of cellular proliferation and gastric mucus content, reducing inflammatory parameters and oxidative stress. In addition, the repeated 7 days-treatment of animals with RGal did not show alterations of clinical and behavioral symptoms, body and organs weights or plasmatic biochemical parameters. Collectively, these results showed that RGal has an interesting antiulcerogenic activity and could constitute an attractive molecule of interest for the development of new antiulcer agents.
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Daniele
authors.initials: D
authors.lastname: Maria-Ferreira
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Luisa Mota
authors.initials: LM
authors.lastname: da Silva
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Daniel Augusto Gasparin Bueno
authors.initials: DA
authors.lastname: Mendes
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Daniela de Almeida
authors.initials: Dde A
authors.lastname: Cabrini
authors.affiliation: Department of Biochemistry and Molecular Biology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Adamara Machado
authors.initials: AM
authors.lastname: Nascimento
authors.affiliation: Department of Biochemistry and Molecular Biology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Marcello
authors.initials: M
authors.lastname: Iacomini
authors.affiliation: Department of Biochemistry and Molecular Biology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Thales Ricardo
authors.initials: TR
authors.lastname: Cipriani
authors.affiliation: Department of Physiological Sciences, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
authors.forename: Adair Roberto Soares
authors.initials: AR
authors.lastname: Santos
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Maria Fernanda de Paula
authors.initials: MF
authors.lastname: Werner
authors.affiliation: Department of Pharmacology, Sector of Biological Sciences, Federal University of Paraná, Curitiba, PR, Brazil.
authors.forename: Cristiane Hatsuko
authors.initials: CH
authors.lastname: Baggio
mesh_terms: D019342:Acetic Acid / Q000009:adverse effects; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism; D019659:Asteraceae / Q000737:chemistry*; D001835:Body Weight / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D019610:Cytoprotection / Q000187:drug effects*; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D009077:Mucins / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010368:Pectins / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects* / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000897:Anti-Ulcer Agents; D000975:Antioxidants; D009077:Mucins; D000431:Ethanol; D010368:Pectins; D005978:Glutathione; D019342:Acetic Acid