title: Multiple cysts in kidneys: a case report.
abstract: Von Hippel-Lindau (VHL) disease, which is an autosomal dominant inherited disease, is characterized by highly vascularized tumors in different organs. We report a 42-year-old male who presented to our hospital with diarrhea and weight loss of six months' duration. Ultrasonography of the abdomen revealed bilateral polycystic kidneys with multiple cystic and solid components as well as polycystic pancreas. A computerized tomography scan of the abdomen revealed bilateral multiple simple and complex renal cysts, cystic lesions in the head and body of the pancreas and a non-enhancing lesion in the left adrenal gland. The features raised the possibility of VHL syndrome and a biopsy of the kidney revealed atypical cells with a suspicion of malignancy. He underwent bilateral nephrectomy and is on maintenance dialysis since then.
authors.affiliation: Department of Endocrinology, Medwin Hospitals, Nampally, Hyderabad, A.P., India.
authors.forename: K V S Hari
authors.initials: KV
authors.lastname: Kumar
authors.forename: Ratan
authors.initials: R
authors.lastname: Jha
authors.forename: S
authors.initials: S
authors.lastname: Shekhar
authors.forename: K
authors.initials: K
authors.lastname: Sunil
authors.forename: K D
authors.initials: KD
authors.lastname: Modi
mesh_terms: D000328:Adult; D001706:Biopsy; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D002908:Chronic Disease; D003967:Diarrhea / Q000209:etiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D008297:Male; D009154:Mutation; D009392:Nephrectomy; D010181:Pancreatic Cyst / Q000175:diagnosis / Q000235:genetics; D010641:Phenotype; D007690:Polycystic Kidney Diseases / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006435:Renal Dialysis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics; D015431:Weight Loss; D006623:von Hippel-Lindau Disease / Q000175:diagnosis / Q000235:genetics / Q000628:therapy
chemical_list: D051794:Von Hippel-Lindau Tumor Suppressor Protein; C497446:VHL protein, human