title: Modelling of the physiological response of the brain to ischaemic stroke.
abstract: Identification of salvageable brain tissue is a major challenge when planning the treatment of ischaemic stroke. As the standard technique used in this context, the perfusion-diffusion mismatch, has not shown total accuracy, there is an ongoing search for new imaging protocols that could better identify the region of the brain at risk and for new physiological models that could, on the one hand, incorporate the imaged parameters and predict the evolution of the condition for the individual, and, on the other hand, identify future biomarkers and thus suggest new directions for the design of imaging protocols. Recently, models of cellular metabolism after stroke and blood-brain barrier transport at tissue level have been introduced. We now extend these results by developing a model of the propagation of key metabolites in the brain's extracellular space owing to stroke-related oedema and chemical concentration gradients between the ischaemic and normal brain. We also couple the resulting chemical changes in the extracellular space with cellular metabolism. Our work enables the first patient-specific simulations of stroke progression with finite volume models to be made.
authors.affiliation: Institute of Biomedical Engineering , Department of Engineering Science , University of Oxford , Oxford , UK.
authors.forename: Piotr
authors.initials: P
authors.lastname: Orlowski
authors.affiliation: Institute of Biomedical Engineering , Department of Engineering Science , University of Oxford , Oxford , UK.
authors.forename: David
authors.initials: D
authors.lastname: O'Neill
authors.affiliation: Institute of Biomedical Engineering , Department of Engineering Science , University of Oxford , Oxford , UK.
authors.forename: Vicente
authors.initials: V
authors.lastname: Grau
authors.affiliation: Institute of Biomedical Engineering , Department of Engineering Science , University of Oxford , Oxford , UK.
authors.forename: Yiannis
authors.initials: Y
authors.lastname: Ventikos
authors.affiliation: Institute of Biomedical Engineering , Department of Engineering Science , University of Oxford , Oxford , UK.
authors.forename: Stephen
authors.initials: S
authors.lastname: Payne
keywords: diffusion; ischaemia; oedema; stroke