title: Maxillomandibular osteomyelitis associated with osteopetrosis.
abstract: Osteopetrosis is a heterogeneous disorder characterized by abnormal bone remodeling and increased bone density primarily due to defective osteoclast resorption. The diagnosis is based on a history of numerous fractures and radiological findings indicative of osteosclerosis, usually sufficient for a definitive diagnosis. We present a quite rare case of osteopetrosis complicated by recurrent episodes of maxillomandibular osteomyelitis associated with cutaneous fistulization and purulent nasal discharge. We used intravenous antibiotic therapy and necrotic bone debridement that prevented the appearance of acute infections over a 3-year follow-up, but the complete healing of the case was not achieved.
authors.affiliation: From the *Department of Oral and Maxillofacial Surgery, Virgen del Rocio University Hospital; †Department of Prosthodontics, Faculty of Dentistry, University of Seville; ‡Department of Ophthalmology, Virgen Macarena University Hospital; and §Department of Preventive and Community Dentistry, Faculty of Dentistry, University of Seville, Seville, Spain.
authors.forename: Pedro
authors.initials: P
authors.lastname: Infante-Cossio
authors.forename: Luis-Miguel
authors.initials: LM
authors.lastname: Gonzalez-Perez
authors.forename: Rafael
authors.initials: R
authors.lastname: Martinez-de-Fuentes
authors.forename: Monica
authors.initials: M
authors.lastname: Infante-Cossio
authors.forename: Antonio
authors.initials: A
authors.lastname: Castaño-Seiquer
authors.forename: Emilio
authors.initials: E
authors.lastname: Jimenez-Castellanos
mesh_terms: D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D003131:Combined Modality Therapy; D017577:Cutaneous Fistula / Q000175:diagnosis / Q000601:surgery; D003646:Debridement; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D007571:Jaw Diseases / Q000175:diagnosis* / Q000601:surgery*; D009668:Nose Diseases / Q000175:diagnosis / Q000601:surgery; D010019:Osteomyelitis / Q000175:diagnosis* / Q000601:surgery*; D010020:Osteonecrosis / Q000601:surgery; D010022:Osteopetrosis / Q000175:diagnosis* / Q000601:surgery*; D010026:Osteosclerosis / Q000175:diagnosis* / Q000601:surgery*; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents; D019980:Amoxicillin-Potassium Clavulanate Combination