title: Highly efficient preparation of selectively isotope cluster-labeled long chain fatty acids via two consecutive C(sp3)-C(sp3) cross-coupling reactions.
abstract: An efficient synthesis involving two copper-catalyzed alkyl-alkyl coupling reactions has been designed to easily access doubly isotope-labeled fatty acids. Such NMR- and IR-active compounds were obtained in excellent overall yields and will be further used for determining the conformation of an alkyl chain of lipidic biomolecules upon interaction with proteins.
authors.affiliation: JST ERATO, Lipid Active Structure Project and §Project Research Center for Fundamental Sciences, Osaka University , 1-1 Machikaneyama, Toyonaka, Osaka 560-0043, Japan.
authors.forename: Sébastien
authors.initials: S
authors.lastname: Lethu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Matsuoka
authors.forename: Michio
authors.initials: M
authors.lastname: Murata