title: Palladium-catalyzed acetylation of arenes.
abstract: A simple method for the preparation of aryl methyl ketones is reported. The transformation involves the Pd-catalyzed coupling of an acyl anion equivalent, acetyltrimethylsilane, with aryl bromides to afford the corresponding acetylated arenes in synthetically useful yields. The methodology is tolerant of heterocycles and provides a new method for arene functionalization.
authors.affiliation: Department of Chemistry and Biochemistry University of California , Los Angeles, California 90095-1569, United States.
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Ramgren
authors.forename: Neil K
authors.initials: NK
authors.lastname: Garg
mesh_terms: D000107:Acetylation; D000838:Anions / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000838:Anions; D006571:Heterocyclic Compounds; D007659:Ketones; D010165:Palladium