title: Classification of AIDS-related lymphoma cases between 1987 and 2012 in Japan based on the WHO classification of lymphomas, fourth edition.
abstract: The introduction of combined antiretroviral therapy (ART) has reduced the mortality of patients with human immunodeficiency virus-1 infection worldwide. However, malignant lymphoma is a severe and frequent complication seen in patients with acquired immunodeficiency syndrome (AIDS). The diagnostic criteria for some categories of AIDS-related lymphoma were revised in the World Health Organization International Classification of Lymphoma, fourth edition. The purpose of this study was to assess the clinicopathological characteristics of Japanese patients with AIDS-related lymphoma according to the revised classification. In this retrospective study, 207 AIDS-related lymphoma cases diagnosed between 1987 and 2012 in Japan were subjected to histological subtyping and clinicopathological analyses. Diffuse large B-cell lymphoma (DLBCL) was the predominant histological subtype throughout the study period (n = 104, 50%). Among the DLBCL cases, 24% were of the germinal center (GC) type and 76% were of the non-GC type. Non-GC-type cases showed a significantly lower 1-year survival rate (43%) than the GC-type cases (82%). Cases of Burkitt lymphoma (n = 57, 28%), plasmablastic lymphoma (n = 16, 8%), primary effusion lymphoma (n = 9, 4%), Hodgkin lymphoma (n = 8, 4%), and large B-cell lymphoma arising in Kaposi sarcoma-associated herpesvirus-associated multicentric Castleman disease (n = 2, 1%) were also observed. Hodgkin lymphoma was more common in patients receiving ART (11.1%) than in ART-naïve patients (1.4%). Statistical analyses identified CD10 negativity, BCL-6 negativity, Epstein-Barr virus positivity, and Kaposi sarcoma-associated herpesvirus positivity as risk factors for poor prognosis. This information will help in the early diagnosis of lymphoma in patients with AIDS.
authors.affiliation: Department of Pathology and Laboratory Medicine, Institute of Medical Science, The University of Tokyo, Shirokanedai 4-6-1, Minato-ku, Tokyo, 108-8639, Japan.
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ota
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Hishima
authors.forename: Makoto
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kodama
authors.forename: Suzuko
authors.initials: S
authors.lastname: Moritani
authors.forename: Naoki
authors.initials: N
authors.lastname: Oyaizu
authors.forename: Sohtaro
authors.initials: S
authors.lastname: Mine
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ajisawa
authors.forename: Junko
authors.initials: J
authors.lastname: Tanuma
authors.forename: Tomoko
authors.initials: T
authors.lastname: Uehira
authors.forename: Shotaro
authors.initials: S
authors.lastname: Hagiwara
authors.forename: Keishiro
authors.initials: K
authors.lastname: Yajima
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Koizumi
authors.forename: Takuma
authors.initials: T
authors.lastname: Shirasaka
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kojima
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nagai
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yokomaku
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Shiozawa
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Koibuchi
authors.forename: Aikichi
authors.initials: A
authors.lastname: Iwamoto
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oka
authors.forename: Hideki
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Seiji
authors.initials: S
authors.lastname: Okada
authors.forename: Harutaka
authors.initials: H
authors.lastname: Katano
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000473:pathology; D002648:Child; D055088:Early Detection of Cancer; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000473:pathology*; D015497:HIV-1 / Q000472:pathogenicity; D004854:Herpesvirus 4, Human / Q000472:pathogenicity; D006801:Humans; D017403:In Situ Hybridization; D007564:Japan; D016483:Lymphoma, AIDS-Related / Q000145:classification* / Q000175:diagnosis* / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D051560:Proto-Oncogene Proteins c-bcl-6 / Q000235:genetics; D012189:Retrospective Studies
chemical_list: D051560:Proto-Oncogene Proteins c-bcl-6
keywords: AIDS-related lymphoma; Burkitt lymphoma; Epstein-Barr virus; antiretroviral therapy; diffuse large B-cell lymphoma