title: Synthesis and photophysical property studies of the 2,6,8-triaryl-4-(phenylethynyl)quinazolines.
abstract: The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines via Suzuki-Miyaura cross-coupling with arylboronic acids occurred without selectivity to afford the corresponding 2,6,8-triaryl-4-(phenylethynyl)quinazolines. The absorption and emission properties of these polysubstituted quinazolines were also determined.
authors.affiliation: Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa. mphahmj@unisa.ac.za.
authors.forename: Malose Jack
authors.initials: MJ
authors.lastname: Mphahlele
authors.affiliation: Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa. tkademph@unisa.ac.za.
authors.forename: Hugues Kadem
authors.initials: HK
authors.lastname: Paumo
authors.affiliation: Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa. amelnahas@hotmail.com.
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: El-Nahas
authors.affiliation: Department of Chemistry, College of Science, Engineering and Technology, University of South Africa, P.O. Box 392, Pretoria 0003, South Africa. Morad.elhendawy@yahoo.com.
authors.forename: Morad M
authors.initials: MM
authors.lastname: El-Hendawy
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007455:Iodine / Q000737:chemistry; D008956:Models, Chemical; D010084:Oxidation-Reduction; D011789:Quantum Theory; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet
chemical_list: D011799:Quinazolines; D007455:Iodine