title: Smart designing of new hybrid materials based on brushite-alginate and monetite-alginate microspheres: bio-inspired for sequential nucleation and growth.
abstract: In this report new hybrid materials based on brushite-alginate and monetite-alginate were prepared by self-assembling alginate chains and phosphate source ions via a gelation process with calcium ions. The alginate served as nanoreactor for nucleation and growth of brushite or/and monetite due to its gelling and swelling properties. The alginate gel framework, the crystalline phase and morphology of formed hybrid biomaterials were shown to be strongly dependent upon the concentration of the phosphate precursors. These materials were characterized by thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersive x-ray analysis (EDX).
authors.affiliation: MAScIR Foundation, INANOTECH, Rabat Design, Rue Mohamed El Jazouli, Madinat El Irfane 10100 Rabat, Morocco.
authors.forename: Walid
authors.initials: W
authors.lastname: Amer
authors.affiliation: Centre National pour la Recherche Scientifique et Technique (CNRST), Division UATRS, Angle Allal Fassi/FAR, B.P. 8027, Hay Riad, 10000 Rabat, Morocco.
authors.forename: Karima
authors.initials: K
authors.lastname: Abdelouahdi
authors.affiliation: MAScIR Foundation, INANOTECH, Rabat Design, Rue Mohamed El Jazouli, Madinat El Irfane 10100 Rabat, Morocco.
authors.forename: Hugo Ronald
authors.initials: HR
authors.lastname: Ramananarivo
authors.affiliation: MAScIR Foundation, INANOTECH, Rabat Design, Rue Mohamed El Jazouli, Madinat El Irfane 10100 Rabat, Morocco.
authors.forename: Aziz
authors.initials: A
authors.lastname: Fihri
authors.affiliation: MAScIR Foundation, INANOTECH, Rabat Design, Rue Mohamed El Jazouli, Madinat El Irfane 10100 Rabat, Morocco.
authors.forename: Mounir
authors.initials: M
authors.lastname: El Achaby
authors.affiliation: Laboratoire de Matériaux, Catalyse et Valorisation des Ressources Naturelles, URAC 24, Faculté des Sciences et Techniques, Université Hassan II, Mohammedia B.P. 146, 20650, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Zahouily
authors.affiliation: SUPAGRO-INRA-CIRAD-UMR IATE 1208, Ingenierie des Agropolymères et Technologies Emergentes, 2, Place Pierre Viala-Bât 31, 34060 Montpellier cedex 1, France.
authors.forename: Abdellatif
authors.initials: A
authors.lastname: Barakat
authors.affiliation: CNRS-PROMES Tecnosud, F-66100 Perpignan, France.
authors.forename: Kamal
authors.initials: K
authors.lastname: Djessas
authors.affiliation: Green Chemistry, Centre of Excellence, University of York, York YO10 5DD, UK.
authors.forename: James
authors.initials: J
authors.lastname: Clark
authors.affiliation: MAScIR Foundation, INANOTECH, Rabat Design, Rue Mohamed El Jazouli, Madinat El Irfane 10100 Rabat, Morocco. Electronic address: a.solhy@mascir.com.
authors.forename: Abderrahim
authors.initials: A
authors.lastname: Solhy
mesh_terms: D000464:Alginates / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D032701:Biomimetics / Q000379:methods*; D002130:Calcium Phosphates / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D015195:Drug Design; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008863:Microspheres; D008968:Molecular Conformation; D010316:Particle Size; D013499:Surface Properties
chemical_list: D000464:Alginates; D002130:Calcium Phosphates; D006603:Hexuronic Acids; D046911:Macromolecular Substances; D020723:Glucuronic Acid; C485829:calcium phosphate, dibasic, anhydrous; C494366:calcium phosphate, dibasic, dihydrate
keywords: Alginate; Biopolymers; Brushite; Hybrid materials; Monetite; Phosphates