title: On the TRAIL to overcome BRAF-inhibitor resistance.
abstract: BRAF inhibition has been an instant, although short-lasting, success in BRAF-mutated melanoma treatment. Novel data by Berger et al. now suggest that BRAF-inhibitor-mediated "priming to death" facilitates tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis. We give an overview about the importance of the crosstalk of extrinsic and mitochondrial apoptotic signaling and propose other combination therapies that may prevent or overcome secondary resistance in melanoma.
authors.affiliation: Section of Molecular Dermatology, Medical Faculty Mannheim, Department of Dermatology, Venereology, and Allergology, University Heidelberg, Mannheim, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Geserick
authors.affiliation: The Wistar Institute, Philadelphia, Pennsylvania, USA.
authors.forename: Meenhard
authors.initials: M
authors.lastname: Herlyn
authors.affiliation: Section of Molecular Dermatology, Medical Faculty Mannheim, Department of Dermatology, Venereology, and Allergology, University Heidelberg, Mannheim, Germany. Electronic address: Martin.Leverkus@medma.uni-heidelberg.de.
authors.forename: Martin
authors.initials: M
authors.lastname: Leverkus
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors*; D011725:Pyridines / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000188:drug therapy*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000378:metabolism*
chemical_list: C530671:L-779,450; D011725:Pyridines; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf