title: [Clinical effect analysis of ankylosing spondylitis treated by Chinese medical syndrome differentiation].
abstract: OBJECTIVE
  To evaluate the curative effect and safety of Bushen Qiangji Decoction (BQD) and Qingre Qiangji Decoction (QQD) in treating ankylosing spondylitis (AS) patients, and to verify the clinical utility of AS syndrome differentiation and treatment scheme [Shen-deficiency induced stasis obstruction syndrome (SDISOS) and dampness-heat obstruction syndrome (DHOS) being two basic syndrome types, Shen invigorating blood activating method (SIBAM) and heat clearing dampness resolving method (HCDRM) being two basic treatment methods].
  
  
  METHODS
  Totally 354 AS patients of SDISOS and DHOS were randomly assigned to the treatment group and the control group using a multi-center randomized, positive drug parallel-controlled clinical trail. Patients in treatment group were treated by BQD or QQD according to syndrome typing, while those in the control group took Sulfasalazine enteric-coated tablet (SECT), 24 weeks as one therapeutic course. After treatment, the clinical efficacy was evaluated by using ASAS20 standard (set by Asessment in Ankylosing Spondylitis working group), Chinese medical efficacy evaluation standards, and BASDAI, BASFI, BASMI, night-pain index, spinal pain index, PGA, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR).
  
  
  RESULTS
  After 24 weeks of treatment by BQD or QQD, ASAS20 standard rate was 86.75% in the treatment group, and the total effective rate of Chinese medical syndrome was 85.47%. They could significantly reduce patients' integrals of Chinese medical syndrome, BASDAI, BASFI, BASMI, night-pain index, spinal pain index, and PGA (all P < 0.01).
  
  
  CONCLUSIONS
  QQD and BQD got confirmable clinical effects in treating AS, providing strong evidence of evidence-based medicine for syndrome differentiation and treatment of AS.
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. fxh2188@sina.com
authors.forename: Xing-Hua
authors.initials: XH
authors.lastname: Feng
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Quan
authors.initials: Q
authors.lastname: Jiang
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Hong-Xiao
authors.initials: HX
authors.lastname: Liu
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Wang
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Xia-Xiu
authors.initials: XX
authors.lastname: He
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Hua-Dong
authors.initials: HD
authors.lastname: Zhang
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Xiao-Po
authors.initials: XP
authors.lastname: Tang
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Feng-Quan
authors.initials: FQ
authors.lastname: Xu
authors.affiliation: Affiliated Hospital of Anhui College of Traditional Chinese Medicine, Hefei 230038, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.affiliation: Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China.
authors.forename: Cui-Ying
authors.initials: CY
authors.lastname: Zhou
authors.affiliation: First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300192, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.affiliation: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.
authors.forename: Cai-Yun
authors.initials: CY
authors.lastname: Zhou
authors.affiliation: Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China.
authors.forename: Ming-Li
authors.initials: ML
authors.lastname: Gao
authors.affiliation: Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China.
authors.forename: Ming-Li
authors.initials: ML
authors.lastname: Gao
authors.affiliation: Bethune International Peace Hospital of the People's Liberation Army, Shijiazhuang 050082, China.
authors.forename: Zhen-Bin
authors.initials: ZB
authors.lastname: Li
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.affiliation: Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
mesh_terms: D000293:Adolescent; D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*; D013167:Spondylitis, Ankylosing / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal