title: [Regulatory roles of compound danshen in the downstream path of cyclooxygenases in rheumatoid arthritis patients' synovium].
abstract: Rheumatoid arthritis (RA) belongs to Bi syndrome (arthralgia) in Chinese medicine. Till now there lacks effective therapeutic methods. Recently cyclooxygenases (COXs) inhibitors, having regulator roles for many pro-inflammatory cytokines, have been widely used in RA treatment. But due to existing cardiovascular risks, researches on targeting the downstream specific factors of COXs have been under discussion. Considering the key role of blood stasis syndrome (BSS) in the pathology of RA and the fact that thromboxane A2 (TXA2) plays a pivotal role in BSS, we theoretically explored possible regulatory roles of Compound Danshen, a representative therapy in blood activating stasis removing method in the downstream path of COXs in synovial cells of RA. We proposed a brand new research direction of RA researches.
authors.affiliation: Department of Rheumatology, Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. RY-Huang@hotmail.com
authors.forename: Qing-Chun
authors.initials: QC
authors.lastname: Huang
authors.affiliation: Department of Rheumatology, Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
authors.forename: Yong-Liang
authors.initials: YL
authors.lastname: Chu
authors.affiliation: Department of Rheumatology, Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: He
authors.affiliation: Department of Rheumatology, Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
authors.forename: Run-Yue
authors.initials: RY
authors.lastname: Huang
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D027561:Salvia miltiorrhiza / Q000737:chemistry; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism*
chemical_list: D004365:Drugs, Chinese Herbal; C028972:dan-shen root extract; D011451:Prostaglandin-Endoperoxide Synthases