title: Pluripotent stem cells in regenerative medicine: challenges and recent progress.
abstract: After years of incremental progress, several recent studies have succeeded in deriving disease-relevant cell types from human pluripotent stem cell (hPSC) sources. The prospect of an unlimited cell source, combined with promising preclinical data, indicates that hPSC technology may be on the verge of clinical translation. In this Review, we discuss recent progress in directed differentiation, some of the new technologies that have facilitated the success of hPSC therapies and the remaining hurdles on the road towards developing hPSC-based cell therapies.
authors.affiliation: Center for Stem Cell Biology and Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10065, USA.
authors.forename: Viviane
authors.initials: V
authors.lastname: Tabar
authors.affiliation: 1] Center for Stem Cell Biology and Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10065, USA. [2] Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York 10065, USA.
authors.forename: Lorenz
authors.initials: L
authors.lastname: Studer
mesh_terms: D018929:Cell Culture Techniques / Q000379:methods / Q000639:trends; D002454:Cell Differentiation; D018507:Gene Expression Regulation, Developmental; D005855:Germ Layers / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D044968:Regenerative Medicine / Q000331:legislation & jurisprudence / Q000379:methods* / Q000639:trends; D057170:Translational Research, Biomedical / Q000331:legislation & jurisprudence / Q000379:methods / Q000639:trends