title: Total laryngeal transplant explanted: 14 years of lessons learned.
abstract: In 1998, the first successful total laryngeal transplant was performed. Outstanding voice quality and swallowing function were achieved, and over the subsequent 14 years, much was learned about tolerance of a transplanted larynx. After approximately a decade, a slowly progressive, chronic rejection process gradually rendered the organ nonfunctional, and the patient and his providers deemed him appropriate for explantation. This is a report of the clinical indications and outcome surrounding the explantation of the first successful total laryngeal transplant.
authors.affiliation: Department of Otolaryngology Head & Neck Surgery, Head & Neck Institute, Cleveland Clinic, Cleveland, Ohio, USA.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Lorenz
authors.forename: Marshall
authors.initials: M
authors.lastname: Strome
mesh_terms: D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery; D007825:Laryngectomy / Q000379:methods; D007830:Larynx / Q000637:transplantation*; D016377:Organ Transplantation / Q000009:adverse effects* / Q000379:methods; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000379:methods; D012086:Reoperation / Q000379:methods; D018570:Risk Assessment; D013997:Time Factors; D014019:Tissue Donors; D014181:Transplantation Immunology / Q000502:physiology*
keywords: laryngeal transplantation; larynx transplant