title: The function of BAFF on T helper cells in autoimmunity.
abstract: B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.
authors.affiliation: Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China; Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
authors.forename: Maogen
authors.initials: M
authors.lastname: Chen
authors.affiliation: Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA; Department of Thyroid and Breast Surgery, Huangpu Branch of the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510700, PR China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Lin
authors.affiliation: Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Division of Rheumatology at Penn State University Hershey College of Medicine, Hershey, PA 17033, USA.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.affiliation: Division of Rheumatology and Immunology, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
authors.forename: Yiling
authors.initials: Y
authors.lastname: Deng
authors.affiliation: Institute of Immunology and Transplantation, Shanghai East Hospital at Tongji University, Shanghai, PR China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Research Service, Veterans Affairs Medical Center, Memphis, USA.
authors.forename: David
authors.initials: D
authors.lastname: Brand
authors.affiliation: Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Guo
authors.affiliation: Organ Transplant Center, 1st Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, PR China. Electronic address: gdtrc@163.com.
authors.forename: Xiaoshun
authors.initials: X
authors.lastname: He
authors.affiliation: University of Orléans and Molecular Immunology and Embryology, CNRS UMR6218, Orleans, France; IIDMM, University of Cape Town, South Africa.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Ryffel
authors.affiliation: Division of Rheumatology at Penn State University Hershey College of Medicine, Hershey, PA 17033, USA; Institute of Immunology and Transplantation, Shanghai East Hospital at Tongji University, Shanghai, PR China. Electronic address: szheng1@hmc.psu.edu.
authors.forename: Song Guo
authors.initials: SG
authors.lastname: Zheng
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D053264:B-Cell Activating Factor / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D002454:Cell Differentiation / Q000276:immunology*; D049109:Cell Proliferation; D002470:Cell Survival / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology / Q000473:pathology; D007105:Immune Complex Diseases / Q000276:immunology / Q000473:pathology; D017578:Immunoglobulin Class Switching / Q000276:immunology; D008213:Lymphocyte Activation; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000473:pathology
chemical_list: D001323:Autoantibodies; D053264:B-Cell Activating Factor; C505719:TNFSF13B protein, human
keywords: BAFF; T helper cells; Tfh cells; Th17; Treg cells