title: Chlorogenic acid supplementation improves multifocal electroretinography in patients with retinitis pigmentosa.
abstract: To evaluate the effect of chlorogenic acid supplementation in patients with retinitis pigmentosa, we evaluated objective change in visual function with multifocal electroretinography, along with visual acuity, visual field, standard electroretinography, and contrast sensitivity. Eighteen patients diagnosed with retinitis pigmentosa were enrolled in this prospective, non-comparative, single-arm study. Multifocal electroretinography, best-corrected visual acuity in Early Treatment Diabetic Retinopathy Study letters, total point score on visual field examination with Humphrey Field Analyzer II, electroretinography, and contrast sensitivity were measured and repeated after 3 months supplementation with chlorogenic acid. The amplitude of ring 5 was significantly higher on multifocal electroretinography after 3 months of chlorogenic acid supplementation (7.2 ± 9.5 vs 8.3 ± 10.8 nV/deg(2), mean ± standard deviation, P = 0.022). There were no significant changes in the best-corrected visual acuity, total point score on Humphrey Field Analyzer, 30 Hz flicker amplitude on standard electroretinography, or contrast sensitivity. Chlorogenic acid may have a beneficial effect on the peripheral area at the margins of retinal degeneration, and should be considered as an anti-oxidant for the management of retinitis pigmentosa.
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul National University, Seoul, Korea.
authors.forename: Joo Young
authors.initials: JY
authors.lastname: Shin
authors.affiliation: Department of Ophthalmology, Seoul National University Hospital, Seoul National University, Seoul, Korea. ; Sensory Organs Institute, Medical Research Center, Seoul National University, Seoul, Korea.
authors.forename: Hyeong Gon
authors.initials: HG
authors.lastname: Yu
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000009:adverse effects / Q000627:therapeutic use; D002726:Chlorogenic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D019587:Dietary Supplements / Q000009:adverse effects; D004596:Electroretinography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects; D011446:Prospective Studies; D012160:Retina / Q000503:physiopathology; D012174:Retinitis Pigmentosa / Q000188:drug therapy*; D014785:Vision, Ocular / Q000187:drug effects*; D014792:Visual Acuity / Q000187:drug effects*; D014794:Visual Fields / Q000187:drug effects; D055815:Young Adult
chemical_list: D000975:Antioxidants; D002726:Chlorogenic Acid
keywords: Antioxidants; Chlorogenic Acid; Oxidative Stress; Retinal Degeneration; Retinitis Pigmentosa