title: [Investigation of the effects of cytoflavin on symptoms of depression and autonomic dysfunction in patients with organic depressive disorder].
abstract: The present observational study addressed effects of cytoflavin as an adjunctive nootropic therapy in patients with organic depressive disorder (F06.36). 54 female and 46 male in-patients were included into the study. All patients received standard antidepressant therapy (controls) and 48 patients additionally received 2 pills of cytoflavin twice per day. Age, gender distribution, education and severity of depression were equal in cytoflavin and control groups. The follow-up assessment at discharge showed a significantly more pronounced decline in the severity of depression symptoms in patients receiving cytoflavin in comparison with the controls. Importantly, the effect of cytoflavin on the depression symptoms was prominent only in females. Moreover, women receiving cytoflavin demonstrated the more pronounced normalization of autonomic regulation in comparison with control women. The present results allow to recommend cytoflavin in dose 4 pills daily as an adjunctive therapy in female patients with organic depressive disorder.
authors.affiliation: Kafedra nevrologii i neĭrokhirurgii RNIMU im. N.I. Pirogova, Moskva; Nauchno-prakticheskiĭ psikhonevrologicheskiĭ tsentr Departamenta zdravookhraneniia goroda Moskvy.
authors.forename: A N
authors.initials: AN
authors.lastname: Gudkova
authors.forename: N A
authors.initials: NA
authors.lastname: Osinovskaia
authors.forename: A G
authors.initials: AG
authors.lastname: Polunina
authors.forename: A B
authors.initials: AB
authors.lastname: Gekht
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy*; D003866:Depressive Disorder / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D005486:Flavin Mononucleotide / Q000627:therapeutic use*; D006801:Humans; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use*; D018697:Nootropic Agents / Q000627:therapeutic use*; D012737:Sex Factors; D013386:Succinates / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D004338:Drug Combinations; D018697:Nootropic Agents; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate