title: Two new noroleanane-type triterpene saponins from the methanol extract of Salicornia herbacea.
abstract: Two new noroleanane-type triterpene saponins, Salbige A (1) and Salbige B (2), have been isolated from the aerial parts of Salicornia herbacea together with five other known compounds, including echinocystic acid (3), gypsogenin (4), pheophorbide a (5), (13(2)S)-hydroxy-pheophorbide a (6) and (13(2)S)-hydro-pheophorbide-lactone a (7). The chemical structures of these compounds were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivity. This work represents the first recorded example of the isolation of these compounds from S. herbacea. Compounds 1 and 2 exhibited potent antiproliferative activities and high levels of selectivity towards A549 cancer cells, with IC50 values of 52.35 and 79.39 μM, respectively, whereas compound 5 showed high levels of inhibitory activity against A549 and HepG2 cancer cells with IC50 values of 6.15 and 17.56 μM, respectively. None of these compounds exhibited antioxidant activities except for compound 7, which showed weak antioxidant activity.
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China.
authors.forename: Tianxing
authors.initials: T
authors.lastname: Liu
authors.affiliation: Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, PR China. Electronic address: xzhfood@njau.edu.cn.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Xin
mesh_terms: D001688:Biological Products; D019663:Chenopodiaceae / Q000737:chemistry*; D006801:Humans; D000432:Methanol / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry*
chemical_list: D001688:Biological Products; D012503:Saponins; D014315:Triterpenes; D000432:Methanol
keywords: Antiproliferative activity; Noroleanane-type triterpene saponins; Pheophorbide a; Salicornia herbacea; Structural identification