title: Functional gastrointestinal disorders in patients with familial Mediterranean fever.
abstract: OBJECTIVE
  Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease characterised by recurrent episodes of fever and polyserositis. To date, insufficient data regarding the prevalence of functional gastrointestinal disorders such as irritable bowel syndrome (IBS) and functional dyspepsia (FD) have been reported in patients with FMF. This study aimed to determine the prevalence of functional gastrointestinal disorders in patients with FMF.
  
  
  METHODS
  This study included 122 patients with FMF and a control group of 122 healthy volunteers who were similar with respect to age and sex. Clinical data were collected and gastrointestinal complaints were evaluated according to the Rome III criteria.
  
  
  RESULTS
  IBS was found in 18% of the patients and 10.7% of the controls (P > 0.05). Dyspepsia was reported in 37.7% of the patients and 35.2% of the controls. Constipation was significantly higher in the control group (15.6% vs. 7.4%, P = 0.045), whereas diarrhoea was reported significantly more often in patients with FMF (P = 0.001).
  
  
  CONCLUSIONS
  IBS and dyspepsia were not increased in patients with FMF, whereas diarrhoea was more frequently reported.
authors.affiliation: Department of Internal Medicine, Bozok University Faculty of Medicine, Yozgat, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Börekci
authors.affiliation: Department of Gastroenterology, Bozok University Faculty of Medicine, Yozgat, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Celikbilek
authors.affiliation: Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.
authors.forename: Müjde
authors.initials: M
authors.lastname: Soytürk
authors.affiliation: Department of Rheumatology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey.
authors.forename: Servet
authors.initials: S
authors.lastname: Akar
authors.affiliation: Department of General Surgery, Bozok University Faculty of Medicine, Yozgat, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Börekci
authors.affiliation: Department of Rheumatology, Bozok University Faculty of Medicine, Yozgat, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Günaydin
mesh_terms: D000328:Adult; D003248:Constipation / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003967:Diarrhea / Q000453:epidemiology; D004415:Dyspepsia / Q000453:epidemiology; D010505:Familial Mediterranean Fever / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D043183:Irritable Bowel Syndrome / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology
keywords: Rome criteria; dyspepsia; familial Mediterranean fever; functional gastrointestinal disorders; irritable bowel syndrome