title: Cell migration: sinking in a gradient.
abstract: How chemoattractant gradients form and persist in complex tissues is a key question in cell migration. Two studies now show that CXCR7 acts as a sink in the migrating zebrafish lateral line primordium to generate SDF1 gradients.
authors.affiliation: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Konstadinos
authors.initials: K
authors.lastname: Moissoglu
authors.affiliation: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Ritankar
authors.initials: R
authors.lastname: Majumdar
authors.affiliation: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: parentc@mail.nih.gov.
authors.forename: Carole A
authors.initials: CA
authors.lastname: Parent
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D002630:Chemotactic Factors / Q000378:metabolism*; D006801:Humans; D053403:Lateral Line System / Q000196:embryology*; D054387:Receptors, CXCR / Q000378:metabolism*; D015027:Zebrafish / Q000196:embryology* / Q000502:physiology*; D029961:Zebrafish Proteins / Q000378:metabolism*
chemical_list: D002630:Chemotactic Factors; D054387:Receptors, CXCR; D029961:Zebrafish Proteins