Effects of oral administration of heat-killed Enterococcus faecium strain NHRD IHARA in post-weaning piglets.
Probiotic bacteria such as lactic acid bacteria (LAB) have recently received attention as candidates for alternative anti-microbial feed additives. We previously isolated Enterococcus faecium strain NHRD IHARA (FERM BP-11090, NHRD IHARA strain) and reported its probiotic efficacy. However, we have not determined the effect of oral administration of heat-killed cells of this strain. Here, we performed two experiments to investigate the effect of oral administration of the heat-killed NHRD IHARA strain on post-weaning piglets. In Experiment 1, there was a significant improvement in growth performance (P = 0.04) and increase in serum immunoglobulin A (IgA) production (P = 0.03) in the group fed heat-killed cells. These results were similar to previous results we obtained with live cells. We also found changes in serum and fecal IgA production that were unrelated to the patterns of microbiotal change. In Experiment 2, we detected a significant improvement in villus growth in the jejunum (P = 0.0002). In conclusion, oral administration of the heat-killed NHRD IHARA strain in post-weaning piglets had the same efficacy as administration of the live strain. The heat-killed NHRD IHARA strain can be used as feed additives to improve pig growth and health on commercial farms.
Research and Development Center, Nippon Meat Packers, Inc., Tsukuba, Japan.
Shin
S
Sukegawa
Yasuhiro
Y
Ihara
Kaoruko
K
Yuge
Shengbin
S
Rao
Kentaro
K
Oka
Fumihiro
F
Arakawa
Tatsuya
T
Fujimura
Hiroshi
H
Murakami
Hisao
H
Kurazono
Motomichi
M
Takahashi
Fumiki
F
Morimatsu
D000284:Administration, Oral; D000821:Animal Feed; D000818:Animals; D019587:Dietary Supplements; D016984:Enterococcus faecium / Q000502:physiology*; D006358:Hot Temperature; D007070:Immunoglobulin A / Q000096:biosynthesis* / Q000097:blood; D007422:Intestines / Q000254:growth & development / Q000276:immunology; D019936:Probiotics / Q000008:administration & dosage*; D013552:Swine / Q000254:growth & development* / Q000276:immunology*; D014886:Weaning
D007070:Immunoglobulin A
feed additive; heat-killed cell; lactic acid bacteria; pig; probiotics