Hydrolyzed formulas for allergy prevention.
OBJECTIVE
The aim of the present review was to provide recommendations on the use of hydrolysates in infants when formula feeding is initiated.


METHODS
We performed an overview of reviews followed by a systematic review of subsequently published trials.


RESULTS
We found 8 systematic reviews; only 1 study of limited quality was published afterwards. Certain extensively hydrolyzed casein and certain partially hydrolyzed whey formulas are appropriate for reducing the risk of allergy in infants at high risk when formula feeding is initiated.


CONCLUSIONS
In high-risk infants, when breast-feeding is not possible, hydrolysates of documented safety and efficacy have an indication in infant feeding up to the age 4 to 6 months.
*UZ Brussel, Vrije Universiteit Brussel, Brussels, Belgium †Division of Neonatology, Department of Pediatrics, Georgia Regents University, Augusta ‡Schneider Children's Medical Center of Israel, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel §Department of Pediatrics, IRCCS Ospedale Maggiore Policlinico, DISCCO, University of Milan, Milan, Italy ||Department of Pediatrics, Jeanne de Flandre Lille University Children's Hospital, Faculty of Medicine, University of Lille 2, Lille, France ¶Department of Translation Medical Science, Section of Pediatrics, University of Naples "Federico II," Naples, Italy #Department of Pediatrics, Medical University of Warsaw, Warsaw, Poland.
Yvan
Y
Vandenplas
Jatinder
J
Bhatia
Raanan
R
Shamir
Carlo
C
Agostoni
Dominique
D
Turck
Annamaria
A
Staiano
Hania
H
Szajewska
D000818:Animals; D001942:Breast Feeding; D002364:Caseins; D002417:Cattle; D005512:Food Hypersensitivity / Q000517:prevention & control*; D059022:Food Safety; D006801:Humans; D041943:Infant Formula; D008892:Milk / Q000737:chemistry; D008894:Milk Proteins; D011492:Protein Hydrolysates; D012307:Risk Factors; D000067816:Whey Proteins
D002364:Caseins; D008894:Milk Proteins; D011492:Protein Hydrolysates; D000067816:Whey Proteins