Contribution of small heat shock proteins to muscle development and function.
Investigations undertaken over the past years have led scientists to introduce the concept of protein quality control (PQC) systems, which are responsible for polypeptide processing. The PQC system monitors proteostasis and involves activity of different chaperones such as small heat shock proteins (sHSPs). These proteins act during normal conditions as housekeeping proteins regulating cellular processes, and during stress conditions. They also mediate the removal of toxic misfolded polypeptides and thereby prevent development of pathogenic states. It is postulated that sHSPs are involved in muscle development. They could act via modulation of myogenesis or by maintenance of the structural integrity of signaling complexes. Moreover, mutations in genes coding for sHSPs lead to pathological states affecting muscular tissue functioning. This review focuses on the question how sHSPs, still relatively poorly understood proteins, contribute to the development and function of three types of muscle tissue: skeletal, cardiac and smooth.
Department of Animal Developmental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland.
Magda
M
Dubińska-Magiera
Department of Animal Developmental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland.
Jadwiga
J
Jabłońska
Department of Medical Biochemistry, Medical University, Chalubinskiego 10, 50-368 Wroclaw, Poland.
Jolanta
J
Saczko
Department of Medical Biochemistry, Medical University, Chalubinskiego 10, 50-368 Wroclaw, Poland.
Julita
J
Kulbacka
Institut National de la Santé et de la Recherche Médicale U384, Faculté de Medecine, Clermont-Ferrand, France.
Teresa
T
Jagla
Department of Animal Developmental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland. Electronic address: malgorzata.daczewska@uni.wroc.pl.
Małgorzata
M
Daczewska
D000818:Animals; D050888:Heat-Shock Proteins, Small / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D024510:Muscle Development; D009132:Muscles / Q000378:metabolism / Q000502:physiology*
D050888:Heat-Shock Proteins, Small
Cardiac and smooth muscle; Protein quality control system; Skeletal; Small heat shock protein; Stress