Amphiphilic chitosan derivative-based core-shell micelles: synthesis, characterisation and properties for sustained release of Vitamin D3.
Novel amphiphilic chitosan derivative of N,N-dimethylhexadecyl carboxymethyl chitosan (DCMCs) was synthesised. The physical properties of DCMCs were characterised by Fourier transform-infrared spectroscopy, nuclear magnetic resonance spectroscopy, X-ray diffraction and differential scanning calorimetry. DCMCs can form core-shell micelles with low critical micelle concentration (31 mg L(-1)). The core-shell micelles exhibited spherical shape with positive charge (+50.7 mV) and narrow size distribution (polydispersity index <0.5). Vitamin D3 (VD3) was initially used to load into the core-shell micelles, and the solubility of VD3 was improved with higher encapsulation efficiency (53.2%). The in vitro release processes of VD3 from the core-shell micelles were initially rapid and then followed by a sustained release. The Higuchi model was the most suitable for describing the entire release procedure. DCMCs core-shell micelles are promising carriers for VD3 and other hydrophobic bioactive food factors.
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China.
Wenjian
W
Li
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China; Department of Chemical and Pharmaceutical Engineering, Nanchang University, Nanchang 330031, Jiangxi, China.
Hailong
H
Peng
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China.
Fangjian
F
Ning
School of Life Science, Jiangxi Science & Technology Normal University, Nanchang 330013, Jiangxi, China.
Lihua
L
Yao
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China; Department of Chemical and Pharmaceutical Engineering, Nanchang University, Nanchang 330031, Jiangxi, China.
Mei
M
Luo
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China.
Qiang
Q
Zhao
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China.
Xuemei
X
Zhu
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China. Electronic address: huaxiong100@126.com.
Hua
H
Xiong
D048271:Chitosan / Q000138:chemical synthesis / Q000737:chemistry*; D002762:Cholecalciferol / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008823:Micelles; D010316:Particle Size; D012995:Solubility; D014961:X-Ray Diffraction
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008823:Micelles; D002762:Cholecalciferol; D048271:Chitosan
Core–shell micelle; N,N-Dimethylhexadecyl carboxymethyl chitosan; Self-assemble; Sustained release; Vitamin D(3)