Autoantibodies to transient receptor potential cation channel, subfamily M, member 1 in a Japanese patient with melanoma-associated retinopathy.
OBJECTIVE
To report a case of melanoma-associated retinopathy (MAR) in a Japanese patient found to have autoantibodies to transient receptor potential cation channel, subfamily M, member 1 (TRPM1).


METHODS
An 82-year-old man presented with blurred vision OS as well as night blindness and photopsia OU. Fundus photography, fluorescein angiography, and spectral domain-optical coherence tomography findings were essentially normal. Goldmann perimetry revealed a relative central scotoma, including the blind spot in the right eye, as well as a relative scotoma around a blind spot OS. The full-field scotopic electroretinograms showed a "negative-type" pattern OU, suggestive of extensive bipolar cell dysfunction. Systemic examination revealed that the patient had malignant melanoma of the anus with lung metastasis. Autoantibodies to TRPM1 were detected in the serum of the patient by immunoblot analysis. Vitreous opacity developed during follow-up. The visual symptoms and vitreous opacity of the patient were markedly improved after oral prednisolone therapy. The patient died as a result of widespread metastasis of the melanoma at 11 months after his first visit.


CONCLUSIONS
The present case is the first reported instance of MAR positive for autoantibodies to TRPM1 in an Asian patient.
Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi, 755-8505, Japan.
Yukiko
Y
Morita
Kazuhiro
K
Kimura
Youichiro
Y
Fujitsu
Atsushi
A
Enomoto
Shinji
S
Ueno
Mineo
M
Kondo
Koh-Hei
KH
Sonoda
D000284:Administration, Oral; D000369:Aged, 80 and over; D044466:Asian People; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology*; D004596:Electroretinography; D005451:Fluorescein Angiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015151:Immunoblotting; D008297:Male; D059545:Paraneoplastic Syndromes, Ocular / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use; D050053:TRPM Cation Channels / Q000276:immunology*; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology
D001323:Autoantibodies; D001324:Autoantigens; D005938:Glucocorticoids; D050053:TRPM Cation Channels; C492059:TRPM1 protein, human; D011239:Prednisolone