[On general physical aspects of a problem of in vivo effective detection and recognition of malignant cells].
A fundamentally new recognition method of bio-objects (in particular malignant cells) that escape the immune system supervision control is suggested. Recognition of such bio-objects should be carried out by the unified complex consisting of several molecular groups (for example, antibodies) bound to each other, each group identifies on a surface of this bio-object its target binding site. The choice of such targets is determined by a specific surface-antigen expression profiling. Thus the efficiency of recognition appears to be many times higher, than that in a situation when these molecular groups do not form a uniform complex and operate separately. The possibilities of destruction of such recognized cells are discussed.
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Namiot
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EA
Kogan
D000906:Antibodies / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000235:genetics / Q000276:immunology*; D020869:Gene Expression Profiling; D006801:Humans; D018448:Models, Immunological; D058990:Molecular Targeted Therapy; D050997:Nanomedicine; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009360:Neoplastic Cells, Circulating / Q000276:immunology*; D011485:Protein Binding
D000906:Antibodies; D000951:Antigens, Neoplasm