Neural correlates of own name and own face detection in autism spectrum disorder.
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition clinically characterized by social interaction and communication difficulties. To date, the majority of research efforts have focused on brain mechanisms underlying the deficits in interpersonal social cognition associated with ASD. Recent empirical and theoretical work has begun to reveal evidence for a reduced or even absent self-preference effect in patients with ASD. One may hypothesize that this is related to the impaired attentional processing of self-referential stimuli. The aim of our study was to test this hypothesis. We investigated the neural correlates of face and name detection in ASD. Four categories of face/name stimuli were used: own, close-other, famous, and unknown. Event-related potentials were recorded from 62 electrodes in 23 subjects with ASD and 23 matched control subjects. P100, N170, and P300 components were analyzed. The control group clearly showed a significant self-preference effect: higher P300 amplitude to the presentation of own face and own name than to the close-other, famous, and unknown categories, indicating preferential attentional engagement in processing of self-related information. In contrast, detection of both own and close-other's face and name in the ASD group was associated with enhanced P300, suggesting similar attention allocation for self and close-other related information. These findings suggest that attention allocation in the ASD group is modulated by the personal significance factor, and that the self-preference effect is absent if self is compared to close-other. These effects are similar for physical and non-physical aspects of the autistic self. In addition, lateralization of face and name processing is attenuated in ASD, suggesting atypical brain organization.
Nencki Institute of Experimental Biology, Department of Neurophysiology, Laboratory of Psychophysiology, Warsaw, Poland.
Hanna B
HB
Cygan
Nencki Institute of Experimental Biology, Department of Neurophysiology, Laboratory of Psychophysiology, Warsaw, Poland ; Karolinska Institute, Department of Neuroscience, Brain, Body and Self Laboratory, Stockholm, Sweden.
Pawel
P
Tacikowski
University of Social Sciences and Humanities, Department of Psychology, Warsaw, Poland.
Pawel
P
Ostaszewski
Medical University of Warsaw, Department of Medical Genetics, Warsaw, Poland.
Izabela
I
Chojnicka
Nencki Institute of Experimental Biology, Department of Neurophysiology, Laboratory of Psychophysiology, Warsaw, Poland.
Anna
A
Nowicka
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology* / Q000523:psychology; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology; D005071:Evoked Potentials / Q000502:physiology; D005145:Face; D006801:Humans; D009275:Names; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000502:physiology; D012649:Self Concept; D055815:Young Adult