NON-HOMOGENEOUS POISSON PROCESS MODEL FOR GENETIC CROSSOVER INTERFERENCE.
The genetic crossover interference is usually modeled with a stationary renewal process to construct the genetic map. We propose two non-homogeneous, also dependent, Poisson process models applied to the known physical map. The crossover process is assumed to start from an origin and to occur sequentially along the chromosome. The increment rate depends on the position of the markers and the number of crossover events occurring between the origin and the markers. We show how to obtain parameter estimates for the process and use simulation studies and realDrosophiladata to examine the performance of the proposed models.
Department of Pediatrics, Institute for Clinical and Translational Science, 1115 Hewitt Hall, Zot 1385, University of California, Irvine, Irvine, California 92697, sleu@uci.edu.
Szu-Yun
SY
Leu
Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
Pranab K
PK
Sen
Crossover; Interference; Non-homogeneous; Poisson