Comparative histomorphometric analysis of maxillary sinus augmentation with absorbable collagen membrane and osteoinductive replaceable bony window in rabbits.
OBJECTIVE
The aim of this animal study was to evaluate, through histomorphometric evaluation, bone regeneration in rabbit maxillary sinuses with absorbable collagen membranes and osteoinductive replaceable bony windows over bone grafts.


METHODS
Bilateral sinus augmentation procedures were performed in 16 adult male rabbits. The rabbits were randomly assigned to 4 groups of 4 rabbits each. Rectangular replaceable bony windows were made with a piezoelectric thin saw insert. In control group, grafted β-tricalcium phosphate (β-TCP) was covered by absorbable collagen membranes. In experimental groups, β-TCP was grafted and covered by replaceable bony windows. The rabbits were killed at 1, 2, 4, and 8 weeks postoperatively. The augmented sinuses were stained with hematoxylin-eosin and Masson trichrome stains and examined, under light microscopy, for newly formed bone and soft tissue changes in the maxillary sinuses.


RESULTS
Histologically, significantly higher and faster new bone formation was observed in the augmented sinuses of the experimental groups, receiving homologous replaceable bony windows than in those of the control group receiving collagen membranes.


CONCLUSIONS
This study demonstrates that, for augmentation, the use of the homologous replaceable bony window over bone graft material on the maxillary sinus accelerates bone regeneration.
*Professor, Department of Anatomy, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea. †Professor, Department of Dentistry and Oral and Maxillofacial Surgery, Catholic University Hospital of Daegu, Daegu, Republic of Korea. ‡Assistant Professor, Department of Dentistry and Oral and Maxillofacial Surgery, Catholic University Hospital of Daegu, Daegu, Republic of Korea. §Clinical Instructor, Department of Dentistry and Oral and Maxillofacial Surgery, Catholic University Hospital of Daegu, Daegu, Republic of Korea.
Yong-Suk
YS
Moon
Dong-Seok
DS
Sohn
Jee-Won
JW
Moon
Ju-Hyoung
JH
Lee
In-Sook
IS
Park
Jung-Kwang
JK
Lee
D000818:Animals; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods; D003094:Collagen; D008297:Male; D059745:Piezosurgery / Q000379:methods; D011817:Rabbits; D059546:Sinus Floor Augmentation / Q000295:instrumentation / Q000379:methods*
D003094:Collagen