Aspirin intake correlates with halted growth of sporadic vestibular schwannoma in vivo.
OBJECTIVE
Given the presence of a pathological immune response in sporadic vestibular schwannoma (sVS), this study aims to explore the roles of aspirin in minimizing sVS growth in vivo.


METHODS
Retrospective case review.


METHODS
Tertiary care hospital.


METHODS
People diagnosed with sVS and followed at a tertiary referral center by serial magnetic resonance imaging (MRI) for at least 4 months within the period of January 1980 through April 2012.


METHODS
Patient use of aspirin and sVS growth rate measured by changes in the largest tumor dimension as noted on serial MRIs


RESULTS
Within a set of 689 cases, 347 were followed by serial MRI scans (50.3%); of the latter, 81 took aspirin, of which, 33 demonstrated sVS growth, and 48 did not. Of the 266 nonaspirin users, 154 demonstrated sVS growth, and 112 did not. A significant inverse association was found among aspirin users and sVS growth (odds ratio [OR]: 0.50, 95% confidence interval [CI]: 0.29-0.85), which was not confounded by age or sex.


CONCLUSIONS
Our results suggest a potential therapeutic role of aspirin in inhibiting sVS growth.
*Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston; †Department of Otology and Laryngology, Harvard Medical School, Boston; ‡Program in Speech and Hearing Bioscience and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge; and §Biostatistics Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, U.S.A.
Cherian K
CK
Kandathil
Sonam
S
Dilwali
Chen-Chi
CC
Wu
Metin
M
Ibrahimov
Michael J
MJ
McKenna
Hang
H
Lee
Konstantina M
KM
Stankovic
D001241:Aspirin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000473:pathology*; D012189:Retrospective Studies
D001241:Aspirin