Genetics of diffuse large B-cell lymphoma: paving a path to personalized medicine.
Diffuse large B-cell lymphoma, the most common type of lymphoma in Western countries, remains incurable in approximately 40% of patients. Over the past decade, nascent molecular technologies have led to the discovery of many of the genetic events underlying the pathogenesis of this group of diseases. Whether by defining gene signatures that subclassify diffuse large B-cell lymphoma into subgroups, dysregulation of key cellular pathways, or specific mutations, we are approaching an era in which personalized diagnostics, prognostication, and therapy are imminent.
From the *Perelman School of Medicine at the University of Pennsylvania, The Children's Hospital of Philadelphia; and †Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA.
Rebecca L
RL
King
Adam
A
Bagg
D020869:Gene Expression Profiling; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics* / Q000628:therapy*; D057285:Precision Medicine / Q000379:methods*