Associations of oxidative stress status parameters with traditional cardiovascular disease risk factors in patients with schizophrenia.
BACKGROUND
The purpose of this study was to assess oxidative stress status parameters and their possible associations with traditional cardiovascular risk factors in patients with schizophrenia, as well as their potential for patient-control discrimination.


METHODS
Fasting glucose, lipid profile and oxidative stress status parameters were assessed in 30 schizophrenic patients with atypical antipsychotic therapy and 60 control subjects.


RESULTS
Malondialdehyde (MDA), pro-oxidant/antioxidant balance (PAB) and total anti-oxidant status (TAS) were significantly higher whereas total sulfhydryl (SH) groups were significantly lower in schizophrenic patients vs. control group. Higher serum PAB values showed an independent association with schizophrenia. The addition of PAB to conventional risk factors improved discrimination between healthy control subjects and patients.


CONCLUSIONS
Increased oxidative stress and changed lipid profile parameters are associated in schizophrenic patients and may indicate risk for atherosclerosis. The serum PAB level may reflect the levels of oxidative stress in schizophrenia and improve discrimination of patients from controls.
Department of Bromatology.
Bojana
B
Vidović
Aleksandra
A
Stefanović
Srđan
S
Milovanović
Brižita
B
Ðorđević
Jelena
J
Kotur-Stevuljević
Jasmina
J
Ivanišević
Milica
M
Miljković
Slavica
S
Spasić
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001053:Apolipoproteins / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D011379:Prognosis; D012307:Risk Factors; D012559:Schizophrenia / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D014280:Triglycerides / Q000097:blood
D014150:Antipsychotic Agents; D001053:Apolipoproteins; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D008315:Malondialdehyde