[Colitis-associated colorectal carcinoma: epidemiology, pathogenesis and early diagnosis].
Colitis-associated colorectal carcinoma (CRC) accounts for about 5% of all CRC and the risk for CRC in inflammatory bowel disease (IBD) patients - according to older meta-analyses - is slightly increased when compared to normal population. Effective anti-inflammatory therapy seems to decrease this risk. Main risk factors for colitis-associated CRC are pancolitis, duration of colitis and presence of primary sclerosing cholangitis. In contrast to sporadic CRC, a characteristic adenoma-carcinoma sequence in the pathogenesis of colitis-associated CRC cannot be found. Nevertheless, numerous cell and gene defects occur. Reactive oxygen species also seem to play a pivotal role in the pathogenesis of colitis-associated CRC. Particularly patients with chronically active pancolitis should undergo regular surveillance colonoscopy, since prognosis of colitis-associated CRC is poor.
Klinik für Gastroenterologie und Hepatologie, Departement für Innere Medizin, Universitätsspital Zürich.
Michael
M
Scharl
Klinik für Gastroenterologie und Hepatologie, Departement für Innere Medizin, Universitätsspital Zürich.
Luc
L
Biedermann
Klinik für Gastroenterologie und Hepatologie, Departement für Innere Medizin, Universitätsspital Zürich.
Gerhard
G
Rogler
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control; D042241:Early Diagnosis; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology*; D008403:Mass Screening; D019370:Observation; D017382:Reactive Oxygen Species; D012307:Risk Factors
D000893:Anti-Inflammatory Agents; D017382:Reactive Oxygen Species
Colitis ulcerosa; Colitis-associated colorectal carcinoma; Kolitis-assoziiertes kolorektales Karzinom; carcinome; carcinome colorectal associé à une colite; chronisch-entzündliche Darmerkrankung; colite ulcéreuse; inflammatory bowel disease; maladies inflammatoires chroniques; ulcerative colitis