Evaluation of various silver-containing dressing on infected excision wound healing study.
Silver-containing dressings have been widely used for controlling wound infection. However, the relationship between different concentrations of silver in dressings and their antimicrobial activities and wound-healing efficacies remains unclear. In the present study, we (in cooperation with Bio-medical Carbon Technology) investigated various silver-containing activated carbon fibers to understand the effects of different silver concentrations on the efficacies of a silver containing dressing. Our results indicated that various silver-containing activated carbon fibers exhibited good antibacterial effects and biocompatibility in terms of cell viability and that silver concentration showed a minor influence on cell growth. The infected excision wound model indicated that compared to silver-containing activated carbon fiber and other commercial silver-containing dressings assisted wound healing by promoting granulation and collagen deposition. Meanwhile, the silver ion can only be restrained in epidermis by intact skin. During application on the wound area, a temporary increase of serum silver can be detected, but this elevated serum silver level decreased to a subtle level after the removal of silver-containing activated carbon fiber.
Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, ylhsin@mail.cmu.edu.tw.
Yu-Hsin
YH
Lin
Wei-Shan
WS
Hsu
Wan-Yu
WY
Chung
Tse-Hao
TH
Ko
Jui-Hsiang
JH
Lin
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D001424:Bacterial Infections / Q000473:pathology / Q000628:therapy*; D001458:Bandages; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012834:Silver / Q000008:administration & dosage* / Q000737:chemistry; D013530:Surgical Wound Infection / Q000473:pathology / Q000628:therapy*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D012834:Silver