Comparison of oral and intramuscular recombinant canine distemper vaccination in African wild dogs (Lycaon pictus).
A series of three doses of recombinant canary-pox-vectored canine distemper virus vaccine was administered at 1-mo intervals, orally (n = 8) or intramuscularly (n = 13), to 21 previously unvaccinated juvenile African wild dogs (Lycaon pictus) at the Wildlife Conservation Society's Bronx Zoo. Titers were measured by serum neutralization at each vaccination and at intervals over a period of 3.5-21.5 mo after the initial vaccination. All postvaccination titers were negative for orally vaccinated animals at all sampling time points. Of the animals that received intramuscular vaccinations, 100% had presumed protective titers by the end of the course of vaccination, but only 50% of those sampled at 6.5 mo postvaccination had positive titers. None of the three animals sampled at 21.5 mo postvaccination had positive titers.
Zoological Health, Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, New York 10460, USA. maren.connolly@dallaszoo.com
Maren
M
Connolly
Zoos and Aquarium Division, Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, New York 10460, USA.
Patrick
P
Thomas
Institute of Zoology, Regent's Park, London, NW1 4RY, United Kingdom.
Rosie
R
Woodroffe
Zoological Health, Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, New York 10460, USA.
Bonnie L
BL
Raphael
D000284:Administration, Oral; D000818:Animals; D000836:Animals, Zoo; D028121:Canarypox virus; D046028:Canidae; D004216:Distemper / Q000517:prevention & control*; D004217:Distemper Virus, Canine / Q000276:immunology; D005260:Female; D006391:Hemangioma; D008297:Male; D014611:Vaccination / Q000662:veterinary*; D014614:Vaccines, Synthetic; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
D014614:Vaccines, Synthetic; D014765:Viral Vaccines