There is no association between the serotonin receptor gene and bipolar I disorder in the Korean population.
OBJECTIVE
Despite the close relationship between the functional polymorphism C(-1019)G (rs6295) of the serotonergic 1A receptor (5-HT1A) and mood, few studies have investigated the relationship between rs6295 and bipolar disorder.


OBJECTIVE
In this study, we aimed to investigate whether rs6295 is associated with clinical prognosis and treatment response in patients with bipolar I disorder acute manic episodes.


METHODS
One hundred twenty-eight patients with bipolar I disorder and one hundred sixty-eight healthy controls were recruited. Associations between patients with bipolar I disorder and healthy controls were compared. In addition, age at onset, number of admissions, and treatment response, including response rate, mean changes in manic symptoms, number of anti-manic agents and the total dosage of mood stabilizers for acute manic symptoms were compared between the rs6295 GG and CG+ CC groups in patients with bipolar I disorder. We conducted a separate subgroup analysis according to gender.


RESULTS
There were no differences in frequency between patients and controls. In patients with bipolar disorder, clinical prognosis and treatment response were no different between GG and CG+ CC groups. However, in a subgroup analysis according to gender, male, but not female, patients in the GG group had a longer duration of illness and a greater number of both previous episodes and psychiatric ward admissions than did the GC+ CC group.


CONCLUSIONS
Further studies should investigate the relationship between 5-HT1A polymorphisms and bipolar disorder in terms of mood episode and gender.
Yong-Ku Kim, Department of Psychiatry, Korea University Ansan Hospital , Ansan , Republic of Korea.
Yong-Ku
YK
Kim
Jung-A
JA
Hwang
Heon-Jeong
HJ
Lee
Bun-Hee
BH
Lee
Kyoung-Sae
KS
Na
D000328:Adult; D017668:Age of Onset; D018692:Antimanic Agents / Q000627:therapeutic use; D044466:Asian People / Q000235:genetics; D001714:Bipolar Disorder / Q000188:drug therapy / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D011567:Psychiatric Department, Hospital; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics*; D016896:Treatment Outcome
D018692:Antimanic Agents; C583518:HTR1A protein, human; D044282:Receptor, Serotonin, 5-HT1A
Bipolar disorder; Mood stabilizer; Polymorphism; Serotonin 1A receptor; Treatment