miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models.
MicroRNA alterations and axonopathy have been reported in patients with Alzheimer's disease (AD) and in AD mouse models. We now report that miR-342-5p is upregulated in APP/PS1, PS1ΔE9, and PS1-M146V transgenic AD mice, and that this upregulation is mechanistically linked to elevated β-catenin, c-Myc, and interferon regulatory factor-9. The increased miR-342-5p downregulates the expression of ankyrin G (AnkG), a protein that is known to play a critical role at the axon initial segment. Thus, a specific miRNA alteration may contribute to AD axonopathy by downregulating AnkG.
State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Xiaqin
X
Sun
State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Yu
Y
Wu
State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China.
Mingxue
M
Gu
State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China. Electronic address: yanzhang@pku.edu.cn.
Yan
Y
Zhang
D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D017487:Ankyrins / Q000235:genetics / Q000378:metabolism*; D001369:Axons / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D050834:Interferon-Stimulated Gene Factor 3, gamma Subunit / Q000235:genetics / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D053764:Presenilin-1 / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; C094681:Ank3 protein, mouse; D017487:Ankyrins; D050834:Interferon-Stimulated Gene Factor 3, gamma Subunit; D035683:MicroRNAs; C581863:Mirn342 microRNA, mouse; D053764:Presenilin-1; D016271:Proto-Oncogene Proteins c-myc; D051176:beta Catenin