Interferon beta-related nephropathy and interstitial lung disease: a new association and a long-term warning.
We report on a so-far never described association between glomerulonephritis and sarcoid-like lung disease after long-term interferon beta (IFNb) treatment for relapsing-remitting multiple sclerosis. The interest in this case resides in the documented remission after IFNb discontinuation. The history of IFNb-related adverse events is probably not yet completely written. The rapid reversal of the pathological signs in our patient underlines the importance of careful clinical and laboratory surveillance, including kidney functional parameters, for an early diagnosis of IFNb-related diseases.
SCDO Neurologia 2 - Centro di Riferimento Regionale Sclerosi Multipla, Orbassano, Italy m.capobianco@alice.it.
Marco
M
Capobianco
SS Nefrologia, Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Italy.
Giorgina
G
Piccoli
SS Nefrologia, Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Italy.
Federica
F
Neve Vigotti
Medicina Nucleare, Istituto per la Ricerca e la Cura del Cancro, Candiolo, Italy.
Paola
P
Scapoli
SS Nefrologia, Dipartimento di Scienze Cliniche e Biologiche, Università degli Studi di Torino, Orbassano, Italy.
Maria Chiara
MC
Deagostini
SCDU Pneumologia, Dipartimento di Scienze Cliniche e Biologiche, Univeristà degli Studi di Torino, Orbassano, Italy.
Carlo
C
Albera
Centro Interreggionale Malattie Rare, Università degli Studi di Torino, Torino, Italy.
Dario
D
Roccatello
SCDO Neurologia 2 - Centro di Riferimento Regionale Sclerosi Multipla, Orbassano, Italy.
Antonio
A
Bertolotto
D004334:Drug Administration Schedule; D005260:Female; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000068556:Interferon beta-1a / Q000008:administration & dosage / Q000009:adverse effects*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D000072078:Positron Emission Tomography Computed Tomography; D012074:Remission Induction; D017565:Sarcoidosis, Pulmonary / Q000139:chemically induced* / Q000175:diagnosis; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
D007166:Immunosuppressive Agents; D000068556:Interferon beta-1a
Disease-modifying therapies; adverse event; nephritis; sarcoidosis