[Macrophage activation syndrome: rare complication of murine typhus].
BACKGROUND
Typhi is one of the rickettsial species endemic in the Mediterranean countries and is associated with the zoonotic infection of murine typhus, which may have a complicated course especially in adult patients. The association with macrophage activation syndrome (MAS) has rarely been reported in the medical literature.


METHODS
We describe a case of murine typhus in a diabetic woman complicated with MAS, who was effectively treated with cyclin and parenteral immunoglobulin.


CONCLUSIONS
The murine typhus can be exceptionally complicated with SAM. This infection should be suspected in front of the discovery of SAM.
Service des maladies infectieuses, hôpital Fattouma Bourguiba, 5019 Monastir, Tunisie. Electronic address: loussaief10@yahoo.fr.
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Loussaief
Service des maladies infectieuses, hôpital Fattouma Bourguiba, 5019 Monastir, Tunisie.
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Toumi
Service des maladies infectieuses, hôpital Fattouma Bourguiba, 5019 Monastir, Tunisie.
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Ben Brahim
Service des maladies infectieuses, hôpital Fattouma Bourguiba, 5019 Monastir, Tunisie.
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Aouam
Service d'ophtalmologie, hôpital Fattouma Bourguiba, 5019 Monastir, Tunisie.
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Kairallah
Service des maladies infectieuses, hôpital Fattouma Bourguiba, 5019 Monastir, Tunisie.
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Chakroun
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000740:Anemia / Q000209:etiology / Q000628:therapy; D000907:Antibodies, Bacterial / Q000097:blood; D016913:Blood Component Transfusion; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005076:Exanthema / Q000209:etiology; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008262:Macrophage Activation; D008875:Middle Aged; D012173:Retinitis / Q000209:etiology; D012286:Rickettsia typhi / Q000276:immunology; D013577:Syndrome; D013921:Thrombocytopenia / Q000209:etiology / Q000628:therapy; D014437:Typhus, Endemic Flea-Borne / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology
D000305:Adrenal Cortex Hormones; D000907:Antibodies, Bacterial; D016756:Immunoglobulins, Intravenous; D004318:Doxycycline
Cyclin; Cycline; Macrophage activation syndrome; Murine typhus; Syndrome d’activation macrophagique; Typhus murin