In vitro effects of coital lubricants and synthetic and natural oils on sperm motility.
OBJECTIVE
To evaluate the effects of coital lubricants and oils on sperm motility.


METHODS
Comparative prospective in vitro study.


METHODS
University Andrology laboratory.


METHODS
Twenty-two normozoospermic donors.


METHODS
Semen samples were incubated in modified human tubal fluid (mHTF) control and in 10% Pre-Seed, Astroglide, and KY products (Sensitive, Warming, and Tingling) and baby, canola, sesame, and mustard oils. Total and progressive sperm motility was evaluated before and at 5, 30, and 60 minutes of incubation.


METHODS
Sperm motility.


RESULTS
Control samples exhibited no significant decrease in sperm motility. Pre-Seed showed a slight (∼4%) but significant drop in progressive motility after 30 minutes. Total and progressive sperm motility significantly declined under Astroglide, KY products (Sensitive, Warming, and Tingling) and sesame oil incubation. Canola oil significantly decreased total motility after 30 minutes and progressive motility after 5 minutes of incubation. Similarly, baby oil decreased total motility after 60 minutes and progressive motility after 5 minutes. After initial decline, total and progressive sperm motility under Pre-Seed and canola and baby oils remained high. Exposure to mustard oil caused persistent hyperactivation of sperm in each sample with no decrease in motility.


CONCLUSIONS
Sesame oil and synthetic coital lubricants impaired sperm motility and may hamper fertility. Pre-Seed and canola, mustard, and baby oils showed no deleterious effect and may be considered sperm-friendly coital lubricants. Mustard oil exposure resulted in hyperactivation of sperm and needs to be studied further.
Andrology Laboratory, State University of New York Upstate Medical University, Syracuse, New York.
Ranjit S
RS
Sandhu
Andrology Laboratory, State University of New York Upstate Medical University, Syracuse, New York.
Timothy H
TH
Wong
Andrology Laboratory, State University of New York Upstate Medical University, Syracuse, New York.
Crystal A
CA
Kling
Andrology Laboratory, State University of New York Upstate Medical University, Syracuse, New York. Electronic address: chohank@upstate.edu.
Kazim R
KR
Chohan
D000328:Adult; D002478:Cells, Cultured; D005990:Glycerol / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D054327:Lubricants / Q000494:pharmacology*; D008297:Male; D008899:Mineral Oil / Q000494:pharmacology*; D010938:Plant Oils / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects* / Q000502:physiology; D014622:Vaginal Creams, Foams, and Jellies / Q000494:pharmacology
C076620:Astroglide; D054327:Lubricants; D010938:Plant Oils; D014622:Vaginal Creams, Foams, and Jellies; D008899:Mineral Oil; D005990:Glycerol
Sperm; coital; lubricants; motility; oils