Tumor antigenicity revealed.
The extent to which mutated peptide antigens encoded by somatic mutations contribute to tumor antigenicity in human cancer patients has been unclear. Two recent studies using tumor exome sequencing to predict candidate mutated antigens provide insight into this question.
Department of Pathology, University of Chicago, Chicago, IL 60605, USA. Electronic address: psavage@bsd.uchicago.edu.
Peter A
PA
Savage
D000818:Animals; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation*