Association between complement factor H Val62Ile polymorphism and age-related macular degeneration susceptibility: a meta-analysis.
BACKGROUND
An increasing body of studies has assessed the contribution of Val62Ile polymorphism to age-related macular degeneration (AMD) risk, but the exact association still remains uncertain. This meta-analysis was undertaken in order to further characterize the potential association between Val62Ile polymorphism and AMD risk in four different ethnic populations.


METHODS
A meta-analysis was performed using data available from 16 case-control studies evaluating correlation between the Val62Ile polymorphism and AMD in Caucasian, Chinese, Japanese and South Korean populations. Data extraction and study quality assessment were performed in duplicate. Summary odds ratios (ORs) and 95% confidence intervals (CIs) of allele contrast and genotype contrast were estimated using the random-effects model. The Q-statistic test was used to identify heterogeneity, and the funnel plot was adopted to evaluate publication bias.


RESULTS
Sixteen studies involving a total of 11,400 subjects based on the search criteria were included in the meta-analysis. In overall populations, the Val62Ile polymorphism seemed to be associated with AMD (ORAA vs. GG=0.40, 95% CI=0.28-0.59; ORAA+GA vs. GG=0.72, 95% CI=0.64-0.80; ORAA vs. GC+GG=0.50, 95% CI=0.36-0.70; ORA vs. G=0.68, 95% CI=0.58-0.78; ORGA vs. GG=0.71, 95% CI=0.65-0.77). Similarly, subgroup analysis also revealed that this polymorphism was related to AMD in all ethnicities.


CONCLUSIONS
This meta-analysis suggested that Val62Ile polymorphism was associated with susceptibility to AMD.
Department of Ophthalmology, Chinese PLA General Hospital & Chinese PLA Medical School, 28 Fuxing Road, Beijing 100853, People's Republic of China; Department of Ophthalmology, The 306th Hospital of Chinese PLA, 9 North Anxiang Road, Beijing 100101, People's Republic of China.
Xin
X
Wang
Institute of Oncology, Key Laboratory of Oncology, Cancer Center, Division of Internal Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, 28 Fuxing Road, Beijing 100853, People's Republic of China.
Peiliang
P
Geng
Department of Ophthalmology, Chinese PLA General Hospital & Chinese PLA Medical School, 28 Fuxing Road, Beijing 100853, People's Republic of China.
Ying
Y
Zhang
Department of Ophthalmology, Chinese PLA General Hospital & Chinese PLA Medical School, 28 Fuxing Road, Beijing 100853, People's Republic of China. Electronic address: zmn301@sina.com.
Maonian
M
Zhang
D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D017242:Complement Factor H / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People / Q000235:genetics
C493495:CFH protein, human; D017242:Complement Factor H
Age-related macular degeneration; Complement factor H polymorphism; Meta-analysis