Understanding IFNλ in rheumatoid arthritis.
Unraveling the mechanisms underlying the inflammatory response in rheumatoid arthritis is crucial in order to better understand the disease and to develop novel therapeutic approaches. Although the effect of type I interferons on fibroblasts and in the context of rheumatoid arthritis has been described for some time, little is known on the effects of the type III interferons, also known as IFNλ. In a previous issue, Xu and colleagues demonstrate that one of the members of the IFNλ family, IFNλ1, enhances Toll-like receptor expression and consequently promotes the production of proinflammatory cytokines known to be involved in initiating and maintaining the inflammatory responses in rheumatoid arthritis.
Rik A
RA
de Groen
Bi-Sheng
BS
Liu
André
A
Boonstra
D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000276:immunology* / Q000378:metabolism; D000095022:Interferon Lambda
D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda