Analgesic, anti-inflammatory and anticancer activities of extra virgin olive oil.
Background. In folk medicine, extra virgin olive oil (EVOO) is used as a remedy for a variety of diseases. This study investigates the in vivo antinociceptive, anti-inflammatory, and anti-cancer effects of EVOO on mice and rats. Materials and Methods. In this experimental study, using the acetic acid-induced writhing and formalin tests in mice, the analgesic effect of EVOO was evaluated. Acetylsalicylic acid and morphine were used as standard drugs, respectively. The anti-inflammatory activity was investigated by means of the carrageenan-induced paw edema model in rats using acetylsalicylic acid and dexamethasone as standard drugs. Last, the xenograft model in athymic mice was used to evaluate the anticancer effect in vivo. Results. EVOO significantly decreased acetic acid-induced abdominal writhes and reduces acute and inflammatory pain in the two phases of the formalin test. It has also a better effect than Dexamethasone in the anti-inflammatory test. Finally, the intraperitoneal administration of EVOO affects the growth of HCT 116 tumours xenografted in athymic mice. Conclusion. EVOO has a significant analgesic, anti-inflammatory, and anticancer properties. However, further detailed studies are required to determine the active component responsible for these effects and mechanism pathway.
Laboratoire de Biosurveillance de l'Environnement (LR01/ES14), Equipe REMP "Risque Écologique des Médicaments & Pesticides", Faculté des Sciences de Bizerte, Université de Carthage, 7021 Zarzouna, Tunisia.
Myriam
M
Fezai
INSERM, U848, 94805 Villejuif, France ; Institut Gustave Roussy, 94805 Villejuif, France.
Laura
L
Senovilla
INSERM, U848, 94805 Villejuif, France ; Institut Gustave Roussy, 94805 Villejuif, France ; CNRS UMR5237, CRBM 1919 Route de Mende, 34293 Montpellier, France.
Mohamed
M
Jemaà
Laboratoire de Biosurveillance de l'Environnement (LR01/ES14), Equipe REMP "Risque Écologique des Médicaments & Pesticides", Faculté des Sciences de Bizerte, Université de Carthage, 7021 Zarzouna, Tunisia.
Mossadok
M
Ben-Attia