Nine-year interval recurrence after treatment of boron neutron capture therapy in a patient with glioblastoma: a case report.
Boron neutron capture therapy (BNCT) has been reported to be effective in the patients with glioblastoma multiforme (GBM). Median survival time (MST) of GBM patients treated with BNCT is approximately two years. GBM patients surviving 2 or 3 years are considered long-term survivors. In general, most recurrences are local and dissemination is rare. We report an unusual patient with three recurrences; the first and the second recurrences were local, and the third recurrence was dissemination nine years after BNCT.
Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. Electronic address: tokazaki1978@sirius.ocn.ne.jp.
Toshiyuki
T
Okazaki
Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. Electronic address: kageji@clin.med.tokushima-u.ac.jp.
Teruyoshi
T
Kageji
Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. Electronic address: mizo@yj8.so-net.ne.jp.
Yoshifumi
Y
Mizobuchi
Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. Electronic address: takeshi_edit@yahoo.co.jp.
Takeshi
T
Miyamoto
Department of Neurosurgery, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan. Electronic address: snagahi@clin.med.tokushima-u.ac.jp.
Shinji
S
Nagahiro
D001932:Brain Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000532:radiotherapy*; D006801:Humans; D008137:Longitudinal Studies; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000532:radiotherapy*; D016896:Treatment Outcome; D055815:Young Adult
Boron neutron capture therapy; Dissemination; Glioblastoma; Long-term survival; Recurrence