Eccrine carcinoma in the foot of an Asian elephant (Elephas maximus).
A case of eccrine carcinoma of the interdigital foot glands in a 39-yr-old female Asian elephant (Elephas maximus) from Zagreb Zoo is described. The tumor between the toenails of the right forefoot was surgically removed 3 yr before postmortem examination (2003), and the histopathologic diagnosis was compound eccrine carcinoma characterized with glandular tubular and papillary proliferations, mild cellular pleomorphism, proliferation of the myoepithelial cells with mucoid secretions, and necrosis. Immunohistochemistry revealed strong immunoreactivity to S-100 protein, estrogen, and high-molecular weight cytokeratin. This elephant also had chronic renal fibrosis with uremia.
Department of General Pathology and Pathological Morphology, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia. zgrabar@vef.hr
Zeljko
Z
Grabarević
Department of General Pathology and Pathological Morphology, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia.
Andrea Gudan
AG
Kurilj
Department of General Pathology and Pathological Morphology, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia.
Marko
M
Hohsteter
Department of General Pathology and Pathological Morphology, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia.
Branka
B
Artuković
Government District Veterinarian of Protection Animals and Zoo Veterinarian in Erfurt Zoo, Uber den Krautlandern 71, Erfurt-Urbich 99198, Germany.
Angelica
A
Hinke-Bruckmann
Department of Forensic Veterinary Medicine, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, Zagreb 10000, Croatia.
Petar
P
Dzaja
Clinical Health Center Zagreb, Department of Clinical Pathology, Kispatićeva 12, Zagreb, Croatia.
Zdenka
Z
Hutinec
Department of General Pathology and Pathological Anatomy, School of Medicine of the University of Zagreb, Salata 4, 10000 Zagreb, Croatia.
Sven
S
Seiwerth
Zoological Garden of Zagreb, Maksimirski perivoj bb. Zagreb 10000, Croatia.
Ingeborg
I
Bata
D000818:Animals; D000836:Animals, Zoo; D002277:Carcinoma / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D004606:Elephants; D005260:Female; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*