Safe prescription recommendations for non steroidal anti-inflammatory drugs: consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG).
This article outlines key recommendations for the appropriate prescription of non steroidal anti-inflammatory drugs to patients with different musculoskeletal problems. These recommendations are based on current scientific evidence, and takes into consideration gastrointestinal and cardiovascular safety issues. The recommendations have been agreed on by experts from three scientific societies (Spanish Society of Rheumatology [SER], Spanish Association of Gastroenterology [AEG] and Spanish Society of Cardiology [SEC]), following a two-round Delphi methodology. Areas that have been taken into account encompass: efficiency, cardiovascular risk, gastrointestinal risk, liver risk, renal risk, inflammatory bowel disease, anemia, post-operative pain, and prevention strategies. We propose a patient management algorithm that summarizes the main aspects of the recommendations.
Servicio de Aparato Digestivo, Hospital Clínico Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, España. Electronic address: alanas@unizar.es.
Angel
A
Lanas
Servicio de Reumatología, Hospital del Mar, Universidad Autónoma de Barcelona, Barcelona, España.
Pere
P
Benito
Servicio de Cardiología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, España.
Joaquín
J
Alonso
i+D+I, Unidad de Gestión Clínica de Reumatología, Servicio de Reumatología, Hospital Universitario Virgen Macarena, Sevilla, España.
Blanca
B
Hernández-Cruz
Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, España.
Gonzalo
G
Barón-Esquivias
Unidad de Digestivo, Agencia Sanitaria Costa del Sol, Marbella, Málaga, España.
Ángeles
Á
Perez-Aísa
Servei de Digestiu, Hospital de Sabadell, Universidad Autónoma de Barcelona, CIBERehd, Sabadell, Barcelona, España.
Xavier
X
Calvet
Unidad de Reumatología, Hospital de Tortosa, Tortosa, Tarragona, España.
José Francisco
JF
García-Llorente
Unidad de Investigación, Sociedad Española de Reumatología, Madrid, España.
Milena
M
Gobbo
Servicio de Cardiología y Unidad Coronaria, Hospital Clínico Universitario, Santiago de Compostela, La Coruña, España.
José R
JR
Gonzalez-Juanatey
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000627:therapeutic use*; D003697:Delphi Technique; D006801:Humans; D009140:Musculoskeletal Diseases / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal
Adverse event; Anti-inflamatorios no esteroideos; Cardiovascular; Efecto adverso; Gastrointestinal hemorrhage; Hemorragia gastrointestinal; Non steroidal anti-inflammatory drugs; Peptic ulcer; Úlcera péptica