PTGS2 gene polymorphism -765G>C is associated with coronary artery disease: a meta-analysis.
Previous studies focusing on the association of PTGS2 polymorphism -765G>C with coronary artery disease (CAD) have failed to reach the same conclusion. In the present study, we performed a meta-analysis to systematically summarize the possible association between PTGS2 polymorphism -765G>C and the risk of CAD. We conducted a search of case-control studies on the associations of PTGS2 with susceptibility to CAD in PubMed, EMBASE, and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. CAD risk associated with PTGS2 -765G>C was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95%CI) with the RevMan 5.2 software. Eleven independent case-control studies on PTGS2 -765G>C were included in our meta-analysis. Our results showed that PTGS2 -765G>C was associated with a decreased risk of CAD (OR = 0.66, 95%CI = 0.56-0.79; P < 0.001). This meta-analysis suggests that PTGS2 -765G>C is associated with a decreased risk of CAD.
Department of Cardiac Surgery, Second Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
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Department of Cardiac Surgery, Second Hospital of Jilin University, Jilin University, Changchun, Jilin, China.
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Norman Bethune Medical College, Jilin University, Changchun, Jilin, China.
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Department of Cardiac Surgery, Second Hospital of Jilin University, Jilin University, Changchun, Jilin, China xu6mouse@163.com.
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D000483:Alleles; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias
D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human