Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients.
OBJECTIVE
The Movement Disorder Society sponsored version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a comprehensive instrument for assessing Parkinson's disease (PD). The present study was aimed at determining the relationships between MDS-UPDRS components and health-related quality of life (HRQoL) evaluations in PD patients.


METHODS
An international, multicenter, cross-sectional study was carried out of 435 PD patients assessed with the MDS-UPDRS, Hoehn and Yahr (HY), Clinical Impression Severity for PD, EQ-5D and PD Questionnaire - eight items (PDQ-8). Spearman's rank correlation coefficients, exploratory factor analysis and multiple linear regression models (dependent variables EQ-5D and PDQ-8) were performed.


RESULTS
The participants' age was 66.71 ± 10.32 years (51.5% men). PD duration was 8.52 ± 6.14, and median HY was 2 (range 1-5). The correlation between the EQ-5D index and the MDS-UPDRS ranged from -0.46 (Part IV) to -0.72 (Part II) and for the PDQ-8 index from 0.47 (Part III) to 0.74 (Part II). In multiple regression models with the MDS-UPDRS domains as independent variables, the main determinant for both the EQ-5D index and the PDQ-8 was Part II followed by Part I. After factorial grouping of the cardinal PD manifestations embedded in the MDS-UPDRS Parts III and IV for inclusion into multiple regression models, a factor formed by M-EDL, nM-EDL and fluctuations was the main determinant for both the EQ-5D and PDQ-8 indexes.


CONCLUSIONS
The MDS-UPDRS component most tightly related with the HRQoL measures was a combination of motor and non-motor experiences of daily living.
Alzheimer Center Reina Sofia Foundation and CIBERNED, Carlos III Institute of Health, Madrid, Spain.
P
P
Martínez-Martín
C
C
Rodríguez-Blázquez
M J
MJ
Forjaz
M
M
Alvarez-Sánchez
T
T
Arakaki
A
A
Bergareche-Yarza
A
A
Chade
N
N
Garretto
O
O
Gershanik
M M
MM
Kurtis
J C
JC
Martínez-Castrillo
A
A
Mendoza-Rodríguez
H P
HP
Moore
M
M
Rodríguez-Violante
C
C
Singer
B C
BC
Tilley
J
J
Huang
G T
GT
Stebbins
C G
CG
Goetz
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis* / Q000523:psychology*; D011788:Quality of Life / Q000523:psychology*; D012044:Regression Analysis; D012720:Severity of Illness Index
EQ-5D; MDS-UPDRS; PDQ-8; Parkinson's disease; health-related quality of life; rating scales