Total synthesis and structural revision of (+)-cristatumin C.
Naturally occurring (+)-cristatumin C, a bis-pyrrolidinoindoline diketopiperazine alkaloid isolated from Eurotium cristatum EN-220, is the 2R,3R,11S,15R,2'R,3'R,11'S,15'S enantiomer, as confirmed by total synthesis.
Departamento de Química Orgánica, Universidade de Vigo , Lagoas-Marcosende, 36310 Vigo, Spain.
Paula
P
Lorenzo
Rosana
R
Álvarez
Ángel R
ÁR
de Lera
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D055325:Eurotium / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000470:Alkaloids; C000590076:cristatumin C