Intralesional vincristine use for treatment of squamous cell carcinoma in a puma (Puma concolor).
A 14-yr-old male puma (Puma concolor) was presented to the veterinary staff of the National Zoo in Malaysia for an auricular mass. Squamous cell carcinoma was diagnosed by histologic examination of a biopsy. Systemic administration of chemotherapy using vincristine (0.5 mg/m2 i.v. q. 7 days for six treatments) and prednisolone (2 mg/kg i.m. q. 72 hr x 7 days) caused side effects of vomiting, weight loss, and alopecia and did not improve the size or appearance of the tumor. Intralesional vincristine injections (0.2 mg q. 7 days for two treatments) and prednisolone (2 mg/kg i.m. q. 72 hr x 15 days) were administered, resulting in complete tumor regression after 14 days of treatment.
National Zoo of Malaysia, Ulu Kelang, Ampang, Selangor, 68000, Malaysia. beyotta@gmail.com
Blanca Juarez
BJ
Sandoval
Faculty of Veterinary Medicine, University Putra Malaysia, Serdang, Selangor, 43400, Malaysia.
Azlan Che'
AC
Amat
Faculty of Veterinary Medicine, University Putra Malaysia, Serdang, Selangor, 43400, Malaysia.
Jasni
J
Sabri
National Zoo of Malaysia, Ulu Kelang, Ampang, Selangor, 68000, Malaysia.
Mat Naim
MN
Ramli
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000662:veterinary*; D015552:Injections, Intralesional / Q000662:veterinary; D008297:Male; D046011:Puma; D012878:Skin Neoplasms / Q000188:drug therapy / Q000662:veterinary*; D014750:Vincristine / Q000008:administration & dosage / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D014750:Vincristine