Increased risk of ischemic heart disease in young patients with migraine: a population-based, propensity score-matched, longitudinal follow-up study.
BACKGROUND
The association between migraine and the risk of ischemic heart disease (IHD) remains controversial. The purpose of the present population-based, propensity score-matched follow-up study was to investigate whether young migraineurs are at a higher risk of developing IHD.


METHODS
A total of 11,541 subjects aged between 18 and 45 years with at least two ambulatory visits with the principal diagnosis of migraine in 2001 were enrolled in the migraine group. We used a logistic regression model that included age, sex, pre-existing comorbidities, and socioeconomic status as covariates to compute the propensity score. The non-migraine group consisted of 11,541 propensity score-matched, randomly sampled subjects without migraine. The 3-year IHD-free survival rate and the cumulative incidence of IHD were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched by propensity score was used to estimate the effect of migraine on the risk of developing subsequent IHD.


RESULTS
The mean age in both groups was 32.3 years. During follow-up, 121 subjects in the migraine group and 55 in the non-migraine group developed IHD. The incidence rate of IHD was 4.56 (95% confidence interval [CI], 3.78 to 5.44) per 1000 person-years in the migraine group and 2.00 (95% CI, 1.51 to 2.61) per 1000 person-years in the non-migraine group. Compared to the non-migraine group, the HR of IHD for the migraine group was 2.50 (95% CI, 1.78 to 3.52, P<0.0001).


CONCLUSIONS
This study showed an increased risk of developing IHD in young patients with newly diagnosed migraine.
Department of Anesthesiology, National Taiwan University Hospital, Taipei, Taiwan.
Yi-Chia
YC
Wang
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan.
Chia-Wei
CW
Lin
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan.
Yu-Tsun
YT
Ho
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Yu-Lin Branch, Yunlin, Taiwan.
Ya-Pin
YP
Huang
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan; Department of Physical Medicine and Rehabilitation, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: panslcb@gmail.com.
Shin-Liang
SL
Pan
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000453:epidemiology*; D017202:Myocardial Ischemia / Q000453:epidemiology*; D057216:Propensity Score; D016016:Proportional Hazards Models; D012307:Risk Factors; D055815:Young Adult
Ischemic heart disease; Migraine; Propensity score; Risk factors