Thyroid metastasis from nonsmall cell lung cancer.
Background. Thyroid metastases are rare. Clinically, they represent less than 4% of thyroid malignancy in clinical studies. Aim. To assess various presentations and therapy for patients with lung cancer metastatic in the thyroid. Materials and Methods. We report a case of metastatic adenocarcinoma of the lung to the thyroid. We reviewed similar reports through PubmMed search from 1997 until 2013. Case Presentation. A 48-year-old lady was seen in the clinic for an adenocarcinoma of left upper lobe (LUL) of the lung; she received neoadjuvant chemotherapy then LUL lobectomy. After 9 months she presented with diffuse goiter initially believed to be a solitary metastatic lesion as it was positive for adenocarcinoma of lung origin on histopathological exam with TTF-1 positivity. Unfortunately, PET scan showed additional mediastinal lymphadenopathy. Conclusion. The treatment strategy for metastatic thyroid disease is based on a multidisciplinary approach, where thyroidectomy would have been considered in case of a solitary metastatic involvement, but further metastatic workup is mandated to direct further systemic therapy versus palliative radiation therapy.
Division of Hematology and Oncology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Tariq
T
Namad
Division of Pathology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Jiang
J
Wang
Division of Radiology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Ralph
R
Shipley
Division of Hematology and Oncology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA.
Nagla
N
Abdel Karim