Incorporating β-cyclodextrin with ZnO nanorods: a potentiometric strategy for selectivity and detection of dopamine.
We describe a chemical sensor based on a simple synthesis of zinc oxide nanorods (ZNRs) for the detection of dopamine molecules by a potentiometric approach. The polar nature of dopamine leads to a change of surface charges on the ZNR surface via metal ligand bond formation which results in a measurable electrical signal. ZNRs were grown on a gold-coated glass substrate by a low temperature aqueous chemical growth (ACG) method. Polymeric membranes incorporating β-cyclodextrin (β-CD) and potassium tetrakis (4-chlorophenyl) borate was immobilized on the ZNR surface. The fabricated electrodes were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM) techniques. The grown ZNRs were well aligned and exhibited good crystal quality. The present sensor system displays a stable potential response for the detection of dopamine in 10(-2) mol·L(-1) acetic acid/sodium acetate buffer solution at pH 5.45 within a wide concentration range of 1 × 10(-6) M(-1) × 10(-1) M, with sensitivity of 49 mV/decade. The electrode shows a good response time (less than 10 s) and excellent repeatability. This finding can contribute to routine analysis in laboratories studying the neuropharmacology of catecholamines. Moreover, the metal-ligand bonds can be further exploited to detect DA receptors, and for bio-imaging applications.
Department of Science and Technology, Campus Norrköping, Linköping University, Norrköping SE-60174, Sweden. sami.elhag@liu.se.
Sami
S
Elhag
Department of Science and Technology, Campus Norrköping, Linköping University, Norrköping SE-60174, Sweden. zafar.hussain.ibupoto@liu.se.
Zafar Hussain
ZH
Ibupoto
Department of Science and Technology, Campus Norrköping, Linköping University, Norrköping SE-60174, Sweden. omer.nour@liu.se.
Omer
O
Nur
Department of Science and Technology, Campus Norrköping, Linköping University, Norrköping SE-60174, Sweden. magnus.willander@liu.se.
Magnus
M
Willander
D004298:Dopamine / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D011199:Potentiometry / Q000379:methods*; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry*
D047392:beta-Cyclodextrins; C031215:betadex; D015034:Zinc Oxide; D004298:Dopamine