Analysis of visual appearance of retinal nerve fibers in high resolution fundus images: a study on normal subjects.
The retinal ganglion axons are an important part of the visual system, which can be directly observed by fundus camera. The layer they form together inside the retina is the retinal nerve fiber layer (RNFL). This paper describes results of a texture RNFL analysis in color fundus photographs and compares these results with quantitative measurement of RNFL thickness obtained from optical coherence tomography on normal subjects. It is shown that local mean value, standard deviation, and Shannon entropy extracted from the green and blue channel of fundus images are correlated with corresponding RNFL thickness. The linear correlation coefficients achieved values 0.694, 0.547, and 0.512 for respective features measured on 439 retinal positions in the peripapillary area from 23 eyes of 15 different normal subjects.
Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, University of Technology, Technicka 12, 61600 Brno, Czech Republic ; International Clinical Research Center, Center of Biomedical Engineering, St. Anne's University Hospital Brno, Pekarska 53, 65691 Brno, Czech Republic.
Radim
R
Kolar
Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Ralf P
RP
Tornow
Department of Ophthalmology, University of Erlangen-Nuremberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Robert
R
Laemmer
Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, University of Technology, Technicka 12, 61600 Brno, Czech Republic ; International Clinical Research Center, Center of Biomedical Engineering, St. Anne's University Hospital Brno, Pekarska 53, 65691 Brno, Czech Republic.
Jan
J
Odstrcilik
Pattern Recognition Lab and Erlangen Graduate School of Advanced Optical Technologies, University of Erlangen-Nuremberg, Martensstraße 3, 91058 Erlangen, Germany.
Markus A
MA
Mayer
Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, University of Technology, Technicka 12, 61600 Brno, Czech Republic.
Jiri
J
Gazarek
Department of Biomedical Engineering, Faculty of Electrical Engineering and Communication, University of Technology, Technicka 12, 61600 Brno, Czech Republic.
Jiri
J
Jan
Ophthalmology Clinic of Dr. Tomas Kubena, U Zimniho Stadionu 1759, 760 00 Zlin, Czech Republic.
Tomas
T
Kubena
Ophthalmology Clinic of Dr. Tomas Kubena, U Zimniho Stadionu 1759, 760 00 Zlin, Czech Republic.
Pavel
P
Cernosek
D000465:Algorithms; D001369:Axons / Q000473:pathology*; D003116:Color; D019277:Entropy; D005654:Fundus Oculi; D064368:Healthy Volunteers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009412:Nerve Fibers; D010781:Photography; D012016:Reference Values; D012044:Regression Analysis; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D013499:Surface Properties; D041623:Tomography, Optical Coherence