[Validation of APACHE II and SOFA scores in 2 cohorts of patients with suspected infection and sepsis, not admitted to critical care units].
OBJECTIVE
To validate the APACHE II and SOFA scores in patients with suspected infection in clinical settings other than intensive care units.


METHODS
A secondary analysis was performed on 2,530 adult patients participating in 2 cohort studies, with suspected infection as admission diagnosis within the first 24 h of hospitalization. The performance of both scoring systems was studied in order to set calibration and discrimination, respectively, on the outcomes such as mortality, admission to Intensive Care Unit, development of septic shock, or multiple organ dysfunctions.


RESULTS
The AUC-ROC values for mortality at discharge and on day 28 in the first cohort were around 0.50 for the SOFA and APACHE II scores; whereas for the second cohort the discrimination value was around 0.70. Calibration of both scoring systems for primary outcomes, according to Hosmer-Lemeshow test, showed p>.05 in the first cohort; while in the second cohort calibration it only showed a p>.05 in the case of the SOFA for mortality at hospital discharge.


CONCLUSIONS
This validation study of SOFA and APACHE II scores in patients with suspected infection in-hospital units other than the Intensive Care Unit, showed no consistent performance for calibration and discrimination. Its application in emergency and in-hospital patients is limited.
Grupo Académico de Epidemiología Clínica, Departamento de Medicina Interna, Universidad de Antioquia, Medellín, Colombia.
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Cerro
Grupo Académico de Epidemiología Clínica, Departamento de Medicina Interna, Universidad de Antioquia, Medellín, Colombia.
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Valencia
Grupo Académico de Epidemiología Clínica, Departamento de Medicina Interna, Universidad de Antioquia, Medellín, Colombia.
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Calle
Grupo Académico de Epidemiología Clínica, Departamento de Medicina Interna, Universidad de Antioquia, Medellín, Colombia.
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León
Grupo Académico de Epidemiología Clínica, Departamento de Medicina Interna, Universidad de Antioquia, Medellín, Colombia. Electronic address: fjaimesb@jhsph.edu.
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Jaimes
D018806:APACHE; D000328:Adult; D000368:Aged; D019540:Area Under Curve; D003105:Colombia / Q000453:epidemiology; D005260:Female; D006305:Health Status Indicators; D017052:Hospital Mortality; D006801:Humans; D007239:Infections / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012372:ROC Curve; D018805:Sepsis / Q000401:mortality*
APACHE II; Calibración; Calibration; Discriminación; Discrimination; Emergency; Hospitalization; Infección; Infection; Mortalidad; Mortality; Prognosis; Pronóstico; SOFA; Salas de hospitalización; Urgencias