A one-pot three-component synthesis of 4,6-diarylpyrimidin-2(1H)-ones (DAPMs) using atomized sodium in THF under sonic condition.
A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is developed. The method is mild and inexpensive; yields are high and the reactions go to completion within 10-15 min.
Department of Studies in Chemistry, Central College Campus, Bangalore University, Bengaluru 560 001, India. Electronic address: m_af_pasha@ymail.com.
Mohamed Afzal
MA
Pasha
Department of Studies in Chemistry, Central College Campus, Bangalore University, Bengaluru 560 001, India.
Shrivatsa
S
Nagashree
4,6-Diarylpyrimidin-2(1H)-ones (DAPMs); Aldehydes; Atomized sodium; Methyl ketones; Ultrasound; Urea