Fibromyalgia and cytokines.
Fibromyalgia is a common chronic pain syndrome characterized by widespread pains and characteristic somatic symptoms. Current evidence suggests that cytokines and especially chemokines may have a role in the pathogenesis of this syndrome. Cytokines are small soluble factors that work as immune system messengers. They can be classified as pro-inflammatory and anti-inflammatory cytokines. Chemokines are a special kind of pro-inflammatory cytokines that guide the movement of circulating mononuclear cells to the injured side. Some pro-inflammatory cytokine levels (i.e. IL-1RA, IL-6, and IL-8) and, recently, some chemokines' levels have been found to be increased in patients with fibromyalgia. Thus, herein we review the current knowledge regarding the role of cytokines in fibromyalgia patients and their possible clinical relevance.
Zabludowicz Center for Autoimmune Disease, Sheba Medical Center, Tel Hashomer, Israel; Department of Autoimmune Disease, Hospital Clinic de Barcelona, Spain.
Ignasi
I
Rodriguez-Pintó
Zabludowicz Center for Autoimmune Disease, Sheba Medical Center, Tel Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Nancy
N
Agmon-Levin
Zabludowicz Center for Autoimmune Disease, Sheba Medical Center, Tel Hashomer, Israel.
Amital
A
Howard
Zabludowicz Center for Autoimmune Disease, Sheba Medical Center, Tel Hashomer, Israel; Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Israel. Electronic address: shoenfel@post.tau.ac.il.
Yehuda
Y
Shoenfeld
D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D005356:Fibromyalgia / Q000175:diagnosis / Q000276:immunology* / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism
D018925:Chemokines; D016207:Cytokines; D018836:Inflammation Mediators
Biologic markers; Chemokines; Cytokines; Fibromyalgia; Pain