Four-component reaction of cyclic amines, 2-aminobenzothiazole, aromatic aldehydes and acetylenedicarboxylate.
The four-component reaction of 2-aminobenzothiazole, aromatic aldehydes, acetylenedicarboxylate and piperidine or pyrrolidine in ethanol afforded the functionalized 2-pyrrolidinones containing both benzothiazolyl and piperidinyl (or pyrrolidinyl) units in good yields. On the other hand, the similar four-component reactions resulted in the functionalized morpholinium or piperidinium 2-pyrrolidinon-3-olates in the presence of p-toluenesulfonic acid.
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Hong
H
Gao
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Jing
J
Sun
College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
Chao-Guo
CG
Yan
benzothiazole; domino reaction; electron-deficient alkyne; multicomponent reaction; pyrrolidinone