Lung protection during non-invasive synchronized assist versus volume control in rabbits.
BACKGROUND
Experimental work provides insight into potential lung protective strategies. The objective of this study was to evaluate markers of ventilator-induced lung injury after two different ventilation approaches: (1) a "conventional" lung-protective strategy (volume control (VC) with low tidal volume, positive end-expiratory pressure (PEEP) and paralysis), (2) a physiological approach with spontaneous breathing, permitting synchrony, variability and a liberated airway. For this, we used non-invasive Neurally Adjusted Ventilatory Assist (NIV-NAVA), with the hypothesis that liberation of upper airways and the ventilator's integration with lung protective reflexes would be equally lung protective.


METHODS
In this controlled and randomized in vivo laboratory study, 25 adult White New Zealand rabbits were studied, including five non-ventilated control animals. The twenty animals with aspiration-induced lung injury were randomized to ventilation with either VC (6 mL/kg, PEEP 5 cm H2O, and paralysis) or NIV-NAVA for six hours (PEEP = zero because of leaks). Markers of lung function, lung injury, vital signs and ventilator parameters were assessed.


RESULTS
At the end of six hours of ventilation (n = 20), there were no significant differences between VC and NIV-NAVA for vital signs, PaO2/FiO2 ratio, lung wet-to-dry ratio and broncho-alveolar Interleukin 8 (Il-8). Plasma IL-8 was higher in VC (P <0.05). Lung injury score was lower for NIV-NAVA (P = 0.03). Dynamic lung compliance recovered after six hours in NIV-NAVA but not in VC (P <0.05). During VC, peak pressures increased from 9.2 ± 2.4 cm H2O (hour 1) to 12.3 ± 12.3 cm H2O (hour 6) (P <0.05). During NIV-NAVA, the tracheal end-expiratory pressure was similar to the end-expiratory pressure during VC. Two animals regurgitated during NIV-NAVA, without clinical consequences, and survived the protocol.


CONCLUSIONS
In experimental acute lung injury, NIV-NAVA is as lung-protective as VC 6 ml/kg with PEEP.
Lucia
L
Mirabella
Giacomo
G
Grasselli
Jack J
JJ
Haitsma
Haibo
H
Zhang
Arthur S
AS
Slutsky
Christer
C
Sinderby
Jennifer
J
Beck
D055371:Acute Lung Injury / Q000503:physiopathology* / Q000628:therapy; D000818:Animals; D004195:Disease Models, Animal; D008168:Lung / Q000473:pathology; D011175:Positive-Pressure Respiration / Q000379:methods*; D011817:Rabbits; D011897:Random Allocation; D012119:Respiration; D013990:Tidal Volume; D055397:Ventilator-Induced Lung Injury / Q000473:pathology / Q000517:prevention & control*