Studies on the interaction of isocyanides with imines: reaction scope and mechanistic variations.
The interaction of imines with isocyanides has been studied. The main product results from a sequential process involving the attack of two units of isocyanide, under Lewis acid catalysis, upon the carbon-nitrogen double bond of the imine to form the 4-membered ring system. The scope of the reaction regarding the imine and isocyanide ranges has been determined, and also some mechanistic variations and structural features have been described.
Barcelona Science Park, University of Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Ouldouz
O
Ghashghaei
Barcelona Science Park, University of Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Consiglia Annamaria
CA
Manna
Barcelona Science Park, University of Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Esther
E
Vicente-García
Barcelona Science Park, University of Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, Spain.
Marc
M
Revés
Barcelona Science Park, University of Barcelona, Baldiri Reixac 10-12, 08028 Barcelona, Spain ; Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII sn, 08028 Barcelona, Spain.
Rodolfo
R
Lavilla
azetidines; heterocycles; imines; isocyanides; multicomponent reactions