Treatment of non-healing sternum wound after open-heart surgery with allogenic platelet-rich plasma and fibrin glue-preliminary outcomes.
BACKGROUND
Non-healing wound in the sternal region after coronary arteries bypass graft surgery is a serious complication. For healing a chronic wound, several novel approaches have been proposed recently such as using bone marrow stem cells, platelets and fibrin glue (PFG); but a non-invasive method is highly desirable in the first approach for treatment. The current study was undertaken to evaluate the effect of the combination of PFG in one treatment.


METHODS
We report on the treatment of six patients with life-threatening chronic sternum wounds, which caused septicemia with multi-drug resistant pathogens. The ulcers were extensively debrided initially and were measured and photographed at weekly intervals. The combination of PFG was applied topically on the wound after every 2 days.


RESULTS
The wounds were completely closed in five patients and significantly reduced in size in one. There was no evidence of local or systemic complications and any abnormal tissue formation, keloid or hypertrophic scarring.


CONCLUSIONS
Our study suggests, in the first approach, PFG can be used safely in order to heal a non healing sternum wound following coronary artery bypass surgery.
Department of Cardiac Surgery, Imam Reza Academic Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Abbasi
MA
Tashnizi
Stem cell and Regenerative Medicine Research Group, Department of Clinical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Daryoush Hamidi
DH
Alamdari
Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Mashhad, Iran.
Mohammad Esmail
ME
Khayami
Student Research Committee, Department of Modern Sciences & Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Hamid Reza
HR
Rahimi
Department of Cardiac Surgery, Imam Reza Academic Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Aliasghar
A
Moeinipour
Department of Cardiac Surgery, Imam Reza Academic Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Ahmad
A
Amouzeshi
Research Department of General Surgery, Division of Surgery and Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, Royal Free Hampstead NHS Trust Hospital, London, UK.
Alexander M
AM
Seifalian
Chronic wounds; fibrin glue; platelet-rich plasma; sternal wound