[Chrono-drug delivery system based on the circadian rhythm of transferrin receptor].
Transferrin receptor 1(TfR1) is a key cell surface molecule that regulates the uptake of iron-bound transferrin. TfR1 expression is higher in tumor cells than in normal cells. Thus, intracellular targeting using iron-saturated Tf as a ligand for TfR-mediated endocytosis has attracted attention. TfR1 in colon cancer-bearing mice exhibits a 24-hour rhythm in mRNA and protein levels. The clock-controlled gene c-MYC rhythmically activate the transcription of the TfR1 gene. In addition, the cyclical accumulation of TfR1 causes dosing time-dependent changes in the intratumoral delivery of drug by receptor-mediated endocytosis. Identification of the circadian properties of molecules that are targeted by ligand-directed DDS may aid the choice of the most appropriate time of day for their administration.
Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University.
Naoya
N
Matsunaga
Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University.
Fumiyasu
F
Okazaki
Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University.
Satoru
S
Koyanagi
Department of Pharmaceutics, Graduate School of Pharmaceutical Sciences, Kyushu University.
Shigehiro
S
Ohdo
D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D016503:Drug Delivery Systems; D006801:Humans; D007501:Iron / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism; D011990:Receptors, Transferrin / Q000235:genetics / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism
D011990:Receptors, Transferrin; D014168:Transferrin; D007501:Iron