[Current status and perspectives of the research in Pendred syndrome].
Pendred syndrome is an autosomal recessive disorder characterized by sensorineural hearing loss, goiter, and a partial defect in iodide organification, and is the most common syndromic hearing loss. Hearing loss is congenital in most cases and is accompanied by an enlarged vestibular aqueduct and a Mondini cochlea. Pendred syndrome and autosomal recessive deafness-4 (DFNB4) with enlarged vestibular aqueduct comprise a phenotypic spectrum caused by mutations in SLC26A4. Recently, mutations in FOXI1 and KCNJ10 have also been identified in DFNB4. Molecular mechanism of hearing loss and goiter remains to be elucidated, and therapies which can reverse or prevent the progression of the symptoms are not available. Here, we describe advances in the basic, clinical, and translational studies on Pendred syndrome.
Department of Otolaryngology/Laboratory of Auditory Disorders, National Institute of Sensory Organs, National Tokyo Medical Center.
Tatsuo
T
Matsunaga
Department of Otorhinolarygology, Keiyu Hospital.
Masato
M
Fujioka
Department of Otolaryngology/Laboratory of Auditory Disorders, National Institute of Sensory Organs, National Tokyo Medical Center.
Makoto
M
Hosoya
D000818:Animals; D004195:Disease Models, Animal; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006044:Goiter, Nodular / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D006801:Humans; D026901:Membrane Transport Proteins / Q000378:metabolism; D009154:Mutation; D000076988:Sulfate Transporters; D014723:Vestibular Aqueduct / Q000002:abnormalities* / Q000473:pathology
C477894:FOXI1 protein, human; D051858:Forkhead Transcription Factors; D026901:Membrane Transport Proteins; C085609:SLC26A4 protein, human; D000076988:Sulfate Transporters