Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides.
Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti-tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles.
1] College of Science, China University of Petroleum, Qingdao 266580, China [2] Weifang Biomedical Innovation and Entrepreneurship Service Center, Weifang 261205, China.
Jing
J
Xu
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Cheng-shi
CS
Jiang
College of Science, China University of Petroleum, Qingdao 266580, China.
Zai-long
ZL
Zhang
Weifang Biomedical Innovation and Entrepreneurship Service Center, Weifang 261205, China.
Wen-quan
WQ
Ma
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Yue-wei
YW
Guo
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D018942:Macrolides / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D015394:Molecular Structure; D012118:Resorcinols / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D018942:Macrolides; D012118:Resorcinols