[Chronotherapy--present and future].
Chronotherapy integrates chronoeffective and chronotoxic data to enhance an effectiveness and tolerance of a drug by choosing optimal dosing-time. Chronotherapy is already performed in several diseases such as hypertension, osteoporosis, dyslipidemia and malignant diseases, and improves the prognosis of these patients. However, it is still a new concept for physicians. Efforts are needed to take chronotherapy into dosage regimen by physicians, who have a major role in providing the benefits of chronotherapy to their patients. In addition, chronotherapy studies are not requested for drug evaluations by the regulatory authorities. However, preliminary screening of new drugs for their chronotherapeutic potential is a way of enhancing the research and development in pharmaceutical industries.
Division of Clinical Pharmacology, Department of pharmacology, Jichi Medical University School of Medicine.
Akio
A
Fujimura
D019454:Chronotherapy / Q000379:methods; D057906:Circadian Clocks; D006801:Humans; D006973:Hypertension / Q000628:therapy; D009369:Neoplasms / Q000628:therapy; D010024:Osteoporosis / Q000628:therapy; D011379:Prognosis