Role of reactive oxygen species in pathogenesis of radiocontrast-induced nephropathy.
In vitro and in vivo studies have demonstrated enhanced hypoxia and formation of reactive oxygen species (ROS) in the kidney following the administration of iodinated contrast media, which play a relevant role in the development of contrast media-induced nephropathy. Many studies indeed support this possibility, suggesting a protective effect of ROS scavenging or reduced ROS formation with the administration of N-acetylcysteine and bicarbonate infusion, respectively. Furthermore, most risk factors, predisposing to contrast-induced nephropathy, are prone to enhanced renal parenchymal hypoxia and ROS formation. In this review, the association of renal hypoxia and ROS-mediated injury is outlined. Generated during contrast-induced renal parenchymal hypoxia, ROS may exert direct tubular and vascular endothelial injury and might further intensify renal parenchymal hypoxia by virtue of endothelial dysfunction and dysregulation of tubular transport. Preventive strategies conceivably should include inhibition of ROS generation or ROS scavenging.
Department of Nephrology, "Federico II" University of Naples, 80131 Naples, Italy.
Antonio
A
Pisani
Department of Nephrology, "Federico II" University of Naples, 80131 Naples, Italy.
Eleonora
E
Riccio
Department of Health Sciences, "Magna Graecia" University, Catanzaro, Italy.
Michele
M
Andreucci
Department of Health Sciences, "Magna Graecia" University, Catanzaro, Italy.
Teresa
T
Faga
Department of Health Sciences, "Magna Graecia" University, Catanzaro, Italy.
Michael
M
Ashour
Department of Nephrology, "Federico II" University of Naples, 80131 Naples, Italy.
Antonella
A
Di Nuzzi
National Cancer Institute G. Pascale, Naples, Italy.
Aldo
A
Mancini
Department of Nephrology, "Federico II" University of Naples, 80131 Naples, Italy.
Massimo
M
Sabbatini
D058186:Acute Kidney Injury / Q000378:metabolism* / Q000503:physiopathology; D015687:Cell Hypoxia / Q000528:radiation effects; D003287:Contrast Media / Q000009:adverse effects*; D016166:Free Radical Scavengers / Q000378:metabolism; D006801:Humans; D007049:Iatrogenic Disease / Q000453:epidemiology; D007457:Iodine Radioisotopes / Q000009:adverse effects; D017382:Reactive Oxygen Species / Q000378:metabolism* / Q000528:radiation effects
D003287:Contrast Media; D016166:Free Radical Scavengers; D007457:Iodine Radioisotopes; D017382:Reactive Oxygen Species