Economic burden of seasonal influenza B in France during winter 2010-2011.
BACKGROUND
In France, 2-15% of the population is affected annually by influenza, which causes significant socioeconomic disruption. Nevertheless, despite its importance for policy makers, few published studies have evaluated the impact of influenza B. Therefore, we assessed the costs associated with influenza B during 2010-2011 in France.


METHODS
Cases of lab-confirmed influenza B were analyzed as part of the Influenza B in General Practice Study. Cost calculations were based on micro-costing methods according to the French Health Insurance (FHI) perspective (in Euros, 2011). Costs were compared between age groups using the Kruskal-Wallis test, and when significant, by multiple comparisons based on rank. Moreover, uncertainties were assessed using one-way sensitivity and probabilistic analyses. Overall economic burden was estimated by multiplying cost per patient, flu attack rate, and the French population.


RESULTS
A total of 201 patients were included in the study. We found that the mean cost associated with Influenza B was 72€ (SD: 205) per patient: 70€ (SD: 262) for younger children, 50€ (SD: 195) for older children, 126€ (SD: 180) for adults, and 42€ (SD: 18) for elderly. Thus, we observed significantly different costs between the distinct age groups (p<0.0001). Finally, the economic burden of influenza B for the FHI was estimated to be 145 million Euros (95% CI: 88-201).


CONCLUSIONS
Our findings highlight the important impact of influenza B and encourage further investigation on policy regarding vaccination strategies in France.
GATE-UMR CNRS 5824, University of Lyon, University Lumière Lyon 2, Lyon 1, Lyon, France. maria-laura.silva@univ-lyon2.fr.
Maria Laura
ML
Silva
Lionel
L
Perrier
Hans-Martin
HM
Späth
Isidore
I
Grog
Anne
A
Mosnier
Nathalie
N
Havet
Jean Marie
JM
Cohen
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D002675:Child, Preschool; D017281:Cost of Illness; D005260:Female; D005602:France / Q000453:epidemiology; D017048:Health Care Costs / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009981:Influenza B virus; D007251:Influenza, Human / Q000191:economics* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012621:Seasons; D018709:Statistics, Nonparametric; D055815:Young Adult