Facile assembly of chiral tetrahydrothiopyrans containing four consecutive stereocenters via an organocatalytic enantioselective Michael-Michael cascade.
An organocatalytic enantioselective Michael-Michael cascade reaction has been implemented for the creation of structurally variant chiral tetrahydrothiopyrans. The process is realized by employment of new bifunctional ketothioether enones and proceeds highly enantioselectively with formation of four consecutive stereogenic centers.
Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University , 325 Guohe Road, Shanghai 200433, P. R. China.
Shengzheng
S
Wang
Yongqiang
Y
Zhang
Guoqiang
G
Dong
Shanchao
S
Wu
Kun
K
Fang
Zhengang
Z
Li
Zhenyuan
Z
Miao
Jianzhong
J
Yao
Hao
H
Li
Jian
J
Li
Wannian
W
Zhang
Wei
W
Wang
Chunquan
C
Sheng
D002384:Catalysis; D018360:Crystallography, X-Ray; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D013440:Sulfides / Q000737:chemistry*
D011714:Pyrans; D013438:Sulfhydryl Compounds; D013440:Sulfides; C522033:thiopyran