Synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition.
The synthesis and antifungal activity of ASP9726, a novel echinocandin with potent Aspergillus hyphal growth inhibition and significantly improved MIC against Candida parapsilosis and echinocandin resistant-Candida is described.
Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. Electronic address: hiroshi.morikawa@astellas.com.
Hiroshi
H
Morikawa
Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Masaki
M
Tomishima
Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Natsuko
N
Kayakiri
Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Takanobu
T
Araki
Chemistry Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
David
D
Barrett
Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Souichirou
S
Akamatsu
Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Satoru
S
Matsumoto
Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Satoko
S
Uchida
Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Toru
T
Nakai
Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Shinobu
S
Takeda
Pharmacology Research Laboratories, Astellas Pharma. Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan.
Katsuyuki
K
Maki
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D054714:Echinocandins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
C000592174:ASP9726; D000935:Antifungal Agents; D054714:Echinocandins
ASP9726; Antifungal; Aspergillus fumigatus; Candida spp.; Echinocandin; Natural product