Enterovirus 71 infection-associated acute flaccid paralysis: a case series of long-term neurologic follow-up.
The authors undertook long-term neurologic outcomes of 27 patients aged 0 to 15 years with enterovirus 71-related acute flaccid paralysis from June 1998 to July 2012. Motor function outcome was graded from class I (complete recovery) to class V (permanent paralytic limbs). Twelve of 20 patients (60%) who received intravenous immunoglobulin for treatment of acute flaccid paralysis had motor function outcomes in classes III to V. The median duration of follow-up was 6 months, during which time 7 of 13 patients (54%) with central nervous system infection, 3 of 6 patients (50%) with autonomic nervous system dysregulation, and 3 of 8 patients (37%) with heart failure showed motor function outcomes in classes III to V. These findings suggested that the usage of intravenous immunoglobulin and the severity of disease staging at disease onset might not be able to predict long-term motor function outcomes.
Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Hsiu-Fen
HF
Lee
Institute of Biochemistry and Biotechnology, College of Medicine, Chung Shan Medical University, Taichung, Taiwan Department of Pediatrics, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan chi-cs@hotmail.com.
Ching-Shiang
CS
Chi
D002648:Child; D002675:Child, Preschool; D029821:Enterovirus A, Human; D004769:Enterovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity; D010243:Paralysis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D020127:Recovery of Function; D012720:Severity of Illness Index; D013116:Spinal Cord
D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors
acute flaccid paralysis; enterovirus 71; motor function outcome