An insight on bacterial cellular targets of photodynamic inactivation.
The emergence of microbial resistance is becoming a global problem in clinical and environmental areas. As such, the development of drugs with novel modes of action will be vital to meet the threats created by the rise in microbial resistance. Microbial photodynamic inactivation is receiving considerable attention for its potentialities as a new antimicrobial treatment. This review addresses the interactions between photosensitizers and bacterial cells (binding site and cellular localization), the ultrastructural, morphological and functional changes observed at initial stages and during the course of photodynamic inactivation, the oxidative alterations in specific molecular targets, and a possible development of resistance.
Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.
Eliana
E
Alves
Maria Af
MA
Faustino
Maria Gpms
MG
Neves
Angela
A
Cunha
Joao
J
Tome
Adelaide
A
Almeida
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy; D001419:Bacteria / Q000187:drug effects*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D004249:DNA Damage; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D006801:Humans; D008027:Light; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000737:chemistry / Q000378:metabolism
D000890:Anti-Infective Agents; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species