Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies.
Magnetic resonance spectroscopy (MRS) characteristics of dementia with Lewy bodies (DLB) Alzheimer's disease (AD) and cognitively normal controls were compared. DLB (n = 34), AD (n = 35), and cognitively normal controls (n = 148) participated in a MRS study from frontal, posterior cingulate, and occipital voxels. We investigated DLB patients with preserved hippocampal volumes to determine the MRS changes in DLB with low probability of overlapping AD pathology. DLB patients were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) in the occipital voxel. AD patients were characterized by lower NAA/Cr in the frontal and posterior cingulate voxels. Normal NAA/Cr levels in the frontal voxel differentiated DLB patients with preserved hippocampal volumes from AD patients. DLB and AD patients had elevated choline/creatine, and myo-Inositol/creatine in the posterior cingulate. MRS abnormalities associated with loss of neuronal integrity localized to the occipital lobes in DLB, and the posterior cingulate gyri and frontal lobes in AD. This pattern of MRS abnormalities may have a role in differential diagnosis of DLB and in distinguishing DLB patients with overlapping AD pathology.
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Jonathan
J
Graff-Radford
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Bradley F
BF
Boeve
Department of Neuropathology, Mayo Clinic, Jacksonville, FL, USA.
Melissa E
ME
Murray
Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA.
Tanis J
TJ
Ferman
Department of Health Sciences Research, Division of Biostatistics, Rochester, MN, USA.
Nirubol
N
Tosakulwong
Department of Health Sciences Research, Division of Biostatistics, Rochester, MN, USA.
Timothy G
TG
Lesnick
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Mandie
M
Maroney-Smith
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Matthew L
ML
Senjem
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Jeffrey
J
Gunter
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Glenn E
GE
Smith
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
David S
DS
Knopman
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Clifford R
CR
Jack
Department of Neuropathology, Mayo Clinic, Jacksonville, FL, USA.
Dennis W
DW
Dickson
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Ronald C
RC
Petersen
Department of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: kantarci.kejal@mayo.edu.
Kejal
K
Kantarci
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism / Q000473:pathology; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D009778:Occipital Lobe / Q000378:metabolism / Q000473:pathology*
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine
Alzheimer's disease; Dementia with Lewy bodies; Magnetic resonance spectroscopy