Summary of: dental composite materials and renal function in children.
OBJECTIVE
To examine whether greater exposure to resin-based composite materials, which may intra-orally release bisphenol A (BPA), is associated with worse renal function outcomes in children.


METHODS
Prospective multi-centre study.


METHODS
Community health dental clinics in Boston and Maine from 1997-2005.


METHODS
Five hundred and thirty-four New England Children's Amalgam Trial participants aged six to ten years were randomised to treatment with amalgam or resin-based composite restorations over five years of follow-up.


METHODS
Restorations were placed according to treatment arm, and sealants placed per standard of care. Cumulative composite exposure was calculated using surface-years (each treated surface weighted by number years present).


METHODS
Urinary excretion of albumin, gamma-glutamyl transpeptidase (gamma-GT), and N-acetyl-β-D-glucosaminidase (NAG) were available for 417 children.


RESULTS
Analysis of covariance showed no association between exposure to dental composites, polyacid-modified compomer, or flowable composite dental sealants and preventative resin restorations with levels of renal function. There was no association between composite materials and thresholds indicating renal damage in logistic regression models.


CONCLUSIONS
This study found no harmful associations between dental composite materials and renal function in children. Therefore, concerns about renal function need not be a consideration in the choice of dental restoration material or placement of preventative dental sealants.
Dublin Dental University Hospital Trinity College Dublin, Ireland.
Emma Louise
EL
McGinley
D003188:Composite Resins / Q000009:adverse effects*; D003723:Dental Amalgam / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008297:Male
D003188:Composite Resins; D003723:Dental Amalgam