Cellulase inhibits Burkholderia cepacia biofilms on diverse prosthetic materials.
Burkholderia cepacia is an opportunistic pathogen causing infections in patients with cystic fibrosis. Patients with implanted devices are prone to B. cepacia infections due to its ability to grow as biofilms. Knowing the importance of polysaccharides in a biofilm, enzymes that degrade them were targeted as a possible candidate for antibiofilm agents. In this study, the antibiofilm potential of cellulase against B. cepacia biofilms formed on various prosthetic materials was tested. Cellulase exhibited significant antibiofilm activity against B. cepacia without having much action on its growth, thus ruling out the chance of selection pressure and subsequent development resistance.
Department of Microbiology, PRIST University, Thanjavur, Tamil Nadu, India.
Satish Kumar
SK
Rajasekharan
Samiraj
S
Ramesh
D001234:Aspergillus niger / Q000737:chemistry / Q000201:enzymology; D001407:Bacillus / Q000737:chemistry / Q000201:enzymology; D001426:Bacterial Proteins / Q000378:metabolism / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D016956:Burkholderia cepacia / Q000187:drug effects* / Q000302:isolation & purification / Q000502:physiology; D002480:Cellulase / Q000378:metabolism / Q000494:pharmacology*; D015536:Down-Regulation / Q000187:drug effects; D004866:Equipment Contamination; D005656:Fungal Proteins / Q000378:metabolism / Q000494:pharmacology*; D019736:Prostheses and Implants / Q000382:microbiology*
D001426:Bacterial Proteins; D005656:Fungal Proteins; D002480:Cellulase