Blastic plasmacytoid dendritic cell neoplasms: clinico-immunohistochemical correlations in a series of 91 patients.
Blastic plasmacytoid dendritic cell neoplasm is a rare clinicopathologic entity, characterized by strong skin tropism and a poor prognosis. The diagnosis is generally made by skin biopsy with appropriate immunohistochemical studies. To identify potential biological prognostic factors for blastic plasmacytoid dendritic cell neoplasm, we performed an extended clinico-immunohistochemical study on a series of 91 well-documented cases collected since 1995 by the French Study Group on Cutaneous Lymphomas. Skin biopsies were analyzed using a panel of 12 immunohistochemical markers (CD4, CD56, CD123, CD303, TCL1, CD68, CD2, CD7, TdT, Ki-67, S100, and MX-1). The results were correlated with survival. The 5 most characteristic markers of this entity (CD4, CD56, CD123, CD303, and TCL1) were expressed simultaneously in only 46% of patients. However, when 4 markers were expressed the diagnosis could still be reliably made without resorting to any additional stains. Expression of TdT and/or S100 correlated with varying degrees of maturation. Statistical survival analyses showed that CD303 expression and high proliferative index (Ki-67) were significantly associated with longer survival.
Departments of *Dermatology ‡Pathology, hôpital Lyon Sud, Claude Bernard Lyon 1 University, Hospices Civils de Lyon, Lyon †Department of Statistics, Université claude bernard lyon I, Villeurbanne §Department of Pathology, Hôpital Haut-Lévêque, CHU, Bordeaux ∥Department of Pathology, Hôpital Henri Mondor, APHP, Créteil ¶Department of Pathology, Hôpital Saint-Louis ¶¶Department of Pathology, Hôpital Cochin ***Department of Pathology, Hôpital Necker-Enfants Malades, APHP, Paris #Department of Pathology, Centre hospitalo-universitaire, Montpellier **Department of Pathology, Hôpital Purpan, CHU, Toulouse ††Department of Dermatologie, Hôpital du Bocage §§§Department of Pathology, PTB, CHU ∥∥∥Centre de Pathologie, Dijon ‡‡Department of Pathology, Centre hospitalo-universitaire, Lille §§Department of Pathology, Hôpital Estaing, CHU, Clermont-Ferrand ∥∥Department of Pathology, Hôpital Ch. Nicolle, CHU, Rouen ##Department of Pathology, Hôpital Trousseau, CHU, Tours †††Department of Pathology, Hôpital Avicennes, APHP, Bobigny, France ‡‡‡Department of Pathology, Hôpital Maisonneuve Rosemont, Montréal, QC, Canada.
Fanny
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Julia
Stephane
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Dalle
Gerard
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Duru
Brigitte
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Balme
Béatrice
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Vergier
Nicolas
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Ortonne
Marie D
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Vignon-Pennamen
Valérie
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Costes-Martineau
Laurence
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Lamant
Sophie
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Dalac
Claire
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Delattre
Pierre
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Déchelotte
Philippe
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Courville
Agnès
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Carlotti
Anne
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De Muret
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Fraitag
Annie
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Levy
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Petrella
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D003713:Dendritic Cells / Q000378:metabolism / Q000473:pathology*; D005260:Female; D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D055815:Young Adult
D014408:Biomarkers, Tumor