Cytotoxic polyphenols from a sponge-associated fungus Aspergillus versicolor Hmp-48.
A new dibenzo[1,4]dioxin 1, and two new prenylated diphenyl ethers, 2 and 3, together with six known compounds, 4-9, were isolated from a sponge-associated fungus Aspergillus versicolor Hmp-F48 by bioactivity-guided fractionation. Their structures were elucidated by 1D- and 2D-NMR, and MS analyses. The compounds showed potent cell growth inhibitory activities against HL-60 cell line.
Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, P. R. China, (phone: +86-88087740); School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China.
Xiao
X
Wang
Yanhua
Y
Mou
Jiangchun
J
Hu
Nan
N
Wang
Li
L
Zhao
Li
L
Liu
Shujin
S
Wang
Dali
D
Meng
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011161:Porifera / Q000382:microbiology*; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D059808:Polyphenols
Aspergillus versicolor; Dibenzo[1,4]dioxin; Fungus; Sponges