Too much of a good thing: beta-chain overexpression blocks FcεRI signalling by capturing Lyn in the cytosol.
Department of Biology, Virginia Commonwealth University, Richmond, VA, USA.
J J
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Ryan
D020013:Calcium Signaling; D015536:Down-Regulation; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism*; D007637:Keratoconjunctivitis / Q000378:metabolism*; D008297:Male; D008407:Mast Cells / Q000378:metabolism*; D017455:Receptors, IgE / Q000096:biosynthesis*
C502447:MS4A2 protein, human; D017455:Receptors, IgE