A synergistic combination therapy with paclitaxel and doxorubicin loaded micellar nanoparticles.
Doxorubicin was chemically conjugated to a biodegradable polymeric carrier as a polymer-doxorubicin (polymer-Dox) conjugate via an acid labile Schiff-base bond. Then, paclitaxel was physically encapsulated by the polymer-Dox conjugate to self assemble in water as micellar nanoparticles with both doxorubicin and paclitaxel in one nanoparticle. In this way, doxorubicin and paclitaxel were combined. The preparation of the polymer-doxorubicin conjugates, encapsulation of paclitaxel, characterization of nanoparticles was systematically studied and the biological evaluation of the free drug combination as well as the micellar platform combination in vitro was thoroughly detailed.
Research Center for Gene Therapy, China-Japan Union Hospital, Jilin University, Changchun, China.
Yan
Y
Wang
Endoscopy Center, China-Japan Union Hospital, Jilin University, Changchun, China.
Shurong
S
Ma
Department of Colorectal and Anal Surgery, China-Japan Union Hospital, Jilin University, Changchun, China.
Zhongshi
Z
Xie
Department of Colorectal and Anal Surgery, China-Japan Union Hospital, Jilin University, Changchun, China. Electronic address: haishanzh@163.com.
Haishan
H
Zhang
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D008823:Micelles; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D008823:Micelles; D004317:Doxorubicin; D017239:Paclitaxel
Combination therapy; Doxorubicin; Drug delivery; Nanoparticles; Paclitaxel