Breath tests for the assessment of the orocecal transit time.
Orocecal transit time (OCTT) is one of the main determinant of the hunger ratings and gastrointestinal sensitivity. While marked-isotopes scintigraphy is the gold standard in its determination in the clinical frame, breath tests are cheap, well-tolerated and non-invasive alternatives. In fact C-13 and C-14 stable isotopes breath tests can be used to assess gastric emptying and OCTT in the clinical and research frames. Moreover, hydrogen (H2) lactulose breath test can be used to assess OCTT in the research frame only due to its laxative action; inulin breath test, devoid of this bias, could be replacing it. However, the main limitation in the use of breath tests in the OCTT determination is their low reproducibility.
Department of Pediatrics and Neuropsychiatry, Division of Gastroenterology, University Hospital Umberto I, Sapienza University of Rome, Rome, Italy. emidio.scarpellini@uniroma1.it  
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Scarpellini
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Abenavoli
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Balsano
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Gabrielli
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Luzza
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Tack
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001944:Breath Tests; D005740:Gases; D005746:Gastric Emptying; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology; D005772:Gastrointestinal Transit; D006801:Humans; D007444:Inulin; D007792:Lactulose; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013997:Time Factors
D015415:Biomarkers; D005740:Gases; D007792:Lactulose; D007444:Inulin