Thymoma with osseous metaplasia in an adolescent.
A 13-year-old girl was incidentally found to have a partially calcified anterior mediastinal mass during the work-up for a left humeral lesion. The resected specimen demonstrated a lymphocyte predominant World Health Organization type B1 thymoma with nodules of metaplastic bone consistent with osseous metaplasia. In addition, she had multiple osteochondromas, a periosteal chondroma of the humerus, a metaplastic osseous pseudotumor of the thigh, and other benign-appearing sclerotic foci, all manifestations of what is likely an autosomal dominant disorder.
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd., St. Louis, MO, 63110, USA, farmakiss@mir.wustl.edu.
Shannon G
SG
Farmakis
Thomas E
TE
Herman
Marilyn J
MJ
Siegel
D000293:Adolescent; D002812:Chondroma / Q000473:pathology; D005097:Exostoses, Multiple Hereditary / Q000473:pathology; D005260:Female; D006801:Humans; D006811:Humerus / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008679:Metaplasia; D009999:Ossification, Heterotopic / Q000473:pathology*; D012598:Sclerosis; D013945:Thymoma / Q000473:pathology*; D013953:Thymus Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed