Detection of chromosomal bla(CTX-M-2) in diverse Escherichia coli isolates from healthy broiler chickens.
The rise of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in food-producing animals is a growing concern for public health. We investigated ESBL producers isolated from broiler chickens in Brazil and characterized 19 CTX-M-2-producing E. coli. The ISCR1 was detected upstream of the chromosome-located gene bla(CTX-M-2), associated with sul-1 type integron structure. CTX-M-2-producing E. coli exhibited different PFGE-types and phylogenetic groups, showing a non-clonal dissemination. The sequence types found (ST93, ST155 and ST2309) have been associated with humans and animals worldwide. Herein, we report the chromosomal location of bla(CTX-M-2) on E. coli, highlighting the risks of multidrug-resistant bacteria in food-producing animals.
School of Pharmaceutical Sciences of Ribeirão Preto - São Paulo University (USP), Ribeirão Preto, SP, Brazil.
J C
JC
Ferreira
R A C
RA
Penha Filho
L N
LN
Andrade
A
A
Berchieri
A L C
AL
Darini
D000818:Animals; D001938:Brazil; D002645:Chickens; D002876:Chromosomes, Bacterial; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000382:microbiology / Q000662:veterinary*; D019143:Evolution, Molecular; D006801:Humans; D010802:Phylogeny; D011201:Poultry Diseases / Q000382:microbiology*; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism
C071167:beta-lactamase CTX-2; D001618:beta-Lactamases
Brazil; extended-spectrum beta-lactamase; food- producing animals; poultry; qnr