Vibsatins A and B, two new tetranorvibsane-type diterpenoids from Viburnum tinus cv. variegatus.
Vibsatins A (1) and B (2), a pair of 14,15,16,17-tetranorvibsane-type diterpenoids that feature a bicyclo[4.2.1]nonane moiety formed by a new C-13/C-2 bond, were isolated from the twigs and leaves of Viburnum tinus cv. variegatus. The structures and absolute configurations were elucidated by a combination of NMR spectra, optical rotation, and X-ray diffraction experiments. A possible biogenetic pathway is also proposed. Moreover, vibsatin A (1) enhanced the neurite outgrowth of NGF-mediated PC12 cells at a concentration of 10 μM.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, People's Republic of China.
Xiu
X
Gao
Li-Dong
LD
Shao
Liao-Bin
LB
Dong
Xiao
X
Cheng
Xing-De
XD
Wu
Fei
F
Liu
Wei-Wei
WW
Jiang
Li-Yan
LY
Peng
Juan
J
He
Qin-Shi
QS
Zhao
D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018515:Plant Leaves; D013237:Stereoisomerism; D027925:Viburnum / Q000737:chemistry*; D014961:X-Ray Diffraction
D004224:Diterpenes; C000590611:vibsatin A; C000590612:vibsatin B