T-lineage acute lymphoblastic leukemia and parvovirus infection in a child with neurofibromastosis-1.
Neurofibromatosis (NF-1) patients have an increased risk of developing malignancies most commonly rhabdomyosarcomas, optic gliomas, brain tumors and non-lymphocytic leukemias. Acute lymphoblastic leukemia (ALL) has been infrequently reported in association with NF-1. We describe a rare association of NF-1, T-lineage ALL and parvovirus infection in a 12-year-old child. In addition, it is also to emphasize that a high index of suspicion should be kept for parvovirus B19 infection as a cause of bicytopenia/pancytopenia in ALL patients following induction chemotherapy.
Pallavi
P
Agarwal
Department of Hematology, PGIMER, Chandigarh, India.
Shano
S
Naseem
Neelam
N
Varma
R K
RK
Marwaha
D015703:Antigens, CD / Q000032:analysis; D001773:Blood Cells / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008853:Microscopy; D009456:Neurofibromatosis 1 / Q000150:complications*; D010322:Parvoviridae Infections / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology
D015703:Antigens, CD