[Gastric signet ring cell adenocarcinoma: A distinct entity].
Gastric signet ring cell carcinoma (GSRC) is a distinct entity. Their incidence is increasing. The pathologist plays a central role in the identification of this entity. Diagnosis is based on an adenocarcinoma containing a majority of signet ring cells (above 50 %). The prognosis of GSRC is the same as gastric adenocarcinoma while GSRC appeared more aggressive. Signet ring cells present a low sensitivity to chemotherapy. This review aimed to discuss the histological, the prognostic and the therapeutic aspect of this entity.
CHU Cochin Port-Royal, service de gastro-entérologie, 75014 Paris, France.
Tessa
T
Tabouret
CHU Cochin Port-Royal, service de gastro-entérologie, 75014 Paris, France; Université Paris-Descartes-Sorbonne-Paris-Cité, faculté de médecine, AP-HP, 75006 Paris, France.
Marion
M
Dhooge
CHU Cochin Port-Royal, service d'anatomopathologie, 75014 Paris, France.
Alexandre
A
Rouquette
CHU Cochin Port-Royal, service de gastro-entérologie, 75014 Paris, France.
Catherine
C
Brezault
CHU Cochin Port-Royal, service d'anatomopathologie, 75014 Paris, France.
Frédéric
F
Beuvon
CHU Cochin Port-Royal, service de gastro-entérologie, 75014 Paris, France; Université Paris-Descartes-Sorbonne-Paris-Cité, faculté de médecine, AP-HP, 75006 Paris, France.
Stanislas
S
Chaussade
CHU Cochin Port-Royal, service de gastro-entérologie, 75014 Paris, France; Université Paris-Descartes-Sorbonne-Paris-Cité, faculté de médecine, AP-HP, 75006 Paris, France. Electronic address: romain.coriat@cch.aphp.fr.
Romain
R
Coriat
D000971:Antineoplastic Combined Chemotherapy Protocols; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005743:Gastrectomy; D015390:Gastric Bypass; D005753:Gastric Mucosa / Q000473:pathology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008197:Lymph Node Excision; D020360:Neoadjuvant Therapy; D011379:Prognosis; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000601:surgery / Q000628:therapy; D016019:Survival Analysis