Enantioselective organocatalytic oxaziridination of N-tosyl aldimine catalyzed by Cinchona alkaloid-ester derivatives.
A series of cinchona alkaloid-ester derivatives was synthesized and applied to catalyze the enantioselective oxaziridination of aryl aldimines with m-CPBA. The (R,R)-oxaziridines were obtained in good yields with high enantiomeric excess (ee) values (up to 98%).
Department of Pharmacy, Jilin Medical College, Jilin, China.
Ying
Y
Jin
Tianyi
T
Zhang
Wei
W
Zhang
Sheng
S
Chang
Bo
B
Feng
D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D004951:Esterification; D004952:Esters; D006878:Hydroxides / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D014105:Tosyl Compounds / Q000737:chemistry*
D002930:Cinchona Alkaloids; D004952:Esters; D006878:Hydroxides; D007097:Imines; D014105:Tosyl Compounds; C031356:hydroxide ion
asymmetric; cinchona alkaloid-ester derivatives; oxaziridination