Aligned bacterial PHBV nanofibrous conduit for peripheral nerve regeneration.
The conventional method of peripheral nerve gap treatment is autografting. This method is limited. In this study, an aligned nanofibrous graft was formed using microbial polyester, Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). The regenerative effect of the graft was compared with that of autografting in vivo. To determine the regenerative effect, rats were assessed with sciatic nerve functional index, electromyographic evaluation, and histological evaluation. Results found in this study include PHBV grafts stimulated progressive nerve regeneration, although regeneration was not comparable with that of autografting. We conclude that the study results were promising for aligned bacterial polymeric grafts for peripheral nerve regeneration.
Bayındır Hospital , Söğütözü, Ankara , Turkey.
Murat
M
Demirbilek
Mustafa
M
Sakar
Zeynep
Z
Karahaliloğlu
Ebru
E
Erdal
Eda
E
Yalçın
Gökhan
G
Bozkurt
Petek
P
Korkusuz
Elif
E
Bilgiç
Çağrı Mesut
ÇM
Temuçin
Emir Baki
EB
Denkbaş
D000818:Animals; D020118:Cupriavidus necator / Q000737:chemistry*; D005260:Female; D057139:Nanofibers / Q000737:chemistry*; D009416:Nerve Regeneration / Q000187:drug effects*; D011091:Polyesters / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D054457:Tissue Scaffolds / Q000737:chemistry*; D000094122:Polyhydroxybutyrates
D011091:Polyesters; C052620:poly(3-hydroxybutyrate)-co-(3-hydroxyvalerate); D000094122:Polyhydroxybutyrates
aligned; bacterial PHBV; peripheral nerve regeneration; regenerative medicine; scaffold