Synthesis of bis-cellobiose and bis-glucose derivatives of azacrown macrocycles as hosts in complexes with acetylsalicylic acid and 4-acetamidophenol.
Two new C2 symmetric bis-cellobiose and bis-glucose azacrown derivatives were prepared according to the one-step procedure using azacrown ethers and azidosaccharides. Their complexes with aspirin and paracetamol were studied with the use of proton NMR spectroscopy. It was found that these pseudocryptands bind aspirin and paracetamol but each one in a different manner.
Department of Organic and Applied Chemistry, University of Łódź, Tamka 12, 91-403 Łódź, Poland.
Michalina
M
Pintal
Department of Organic and Applied Chemistry, University of Łódź, Tamka 12, 91-403 Łódź, Poland.
Bogusław
B
Kryczka
Universite de Lorraine, SRSMC UMR7565, Faculte des Sciences et Techniques, B.P. 70239, F-54506 Vandoeuvre-Les-Nancy Cedex, France.
Alain
A
Marsura
Department of Organic and Applied Chemistry, University of Łódź, Tamka 12, 91-403 Łódź, Poland. Electronic address: porwany@chemia.uni.lodz.pl.
Stanisław
S
Porwański
D000082:Acetaminophen / Q000737:chemistry*; D001241:Aspirin / Q000737:chemistry*; D002475:Cellobiose / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D043844:Crown Ethers / Q000138:chemical synthesis*; D005947:Glucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
D043844:Crown Ethers; D002475:Cellobiose; D000082:Acetaminophen; D005947:Glucose; D001241:Aspirin
Azacrown ethers; Cryptands; Host–guest chemistry; Saccharides