TRPV4: new therapeutic target for inflammatory bowel diseases.
The transient receptor potential vanilloid-4 (TRPV4) belongs to a family of ion channels and can be activated by warm temperature, hypotonicity, cell swelling or lipid mediators of the arachidonic cascade. The metabolites or events responsible for TRPV4 activation are associated with inflammation, arguing in favor of a role for this receptor in inflammatory diseases. The first studies have focused their attention on the role of TRPV4 in neurons and endothelial cells but TRPV4 cellular distribution is widespread, particularly in the gastrointestinal tract. Herein, we review a number of studies demonstrating the expression of TRPV4 in the gut, the regulation of its expression and functions by inflammatory mediators in that organ and the consequences of TRPV4 activation or inhibition in the intestine. We further discuss the relevance of considering this receptor as a potential target for therapeutic development in inflammatory bowel diseases.
Université de Toulouse, Université Paul Sabatier,Centre de Physiopathologie de Toulouse Purpan(CPTP), Toulouse, France; INSERM, U1043, Toulouse, France; CNRS, U5282, Toulouse, France. Electronic address: nathalie.vergnolle@inserm.fr.
Nathalie
N
Vergnolle
D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010146:Pain / Q000188:drug therapy / Q000378:metabolism; D013449:Sulfonamides / Q000008:administration & dosage; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors* / Q000378:metabolism*
D018836:Inflammation Mediators; C544743:RN 1734; D013449:Sulfonamides; D050916:TRPV Cation Channels; C416986:TRPV4 protein, human
IBD; Mucosal Inflammation; TRPV4; Visceral Pain