Racial and socioeconomic disparities in malignant carcinoid cancer cause specific survival: analysis of the surveillance, epidemiology and end results national cancer registry.
BACKGROUND
This study hypothesized living in a poor neighborhood decreased the cause specific survival in individuals suffering from carcinoid carcinomas. Surveillance, Epidemiology and End Results (SEER) carcinoid carcinoma data were used to identify potential socioeconomic disparities in outcome.


METHODS
This study analyzed socioeconomic, staging and treatment factors available in the SEER database for carcinoid carcinomas. The Kaplan-Meier method was used to analyze time to events and the Kolmogorov-Smirnov test to compare survival curves. The Cox proportional hazard method was employed for multivariate analysis. Areas under the receiver operating characteristic curves (ROCs) were computed to screen the predictors for further analysis.


RESULTS
There were 38,546 patients diagnosed from 1973 to 2009 included in this study. The mean follow up time (S.D.) was 68.1 (70.7) months. SEER stage was the most predictive factor of outcome (ROC area of 0.79). 16.4% of patients were un-staged. Race/ethnicity, rural urban residence and county level family income were significant predictors of cause specific survival on multivariate analysis, these accounting for about 5% of the difference in actuarial cause specific survival at 20 years of follow up.


CONCLUSIONS
This study found poorer cause specific survival of carcinoid carcinomas of individuals living in poor and rural neighborhoods.
275 S Bryn Mawr Ave, K43, Bryn Mawr, PA 19010 E-mail : cheung.r100@gmail.com.
Rex
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Cheung
D002276:Carcinoid Tumor / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D054625:Healthcare Disparities; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009369:Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D044469:Racial Groups / Q000706:statistics & numerical data*; D018426:SEER Program; D012923:Social Class; D012959:Socioeconomic Factors; D015996:Survival Rate