Discrepancies between Antimullerian Hormone and Follicle Stimulating Hormone in Assisted Reproduction.
Data from 107 women undergoing their first IVF/ICSI were analyzed. Relationships between antimullerian hormone (AMH) and follicle stimulating hormone (FSH) were analyzed after dividing patients into four groups according to AMH/FSH levels. Concordance was noted in 57% of women (both AMH/FSH either normal or abnormal) while 43%of women had discordant values (AMH/FSH one hormone normal and the other abnormal). Group 1 (AMH and FSH in normal range) and group 2 (normal AMH and high FSH) were younger compared to group 3 (low AMH and normal FSH) and group 4 (both AMH/FSH abnormal). Group 1 showing the best oocyte yield was compared to the remaining three groups. Groups 3 and 4 required higher dose of gonadotrophins for controlled ovarian hyperstimulation showing their low ovarian reserve. There was no difference in cycle cancellation, clinical pregnancy, and live birth/ongoing pregnancy rate in all groups. These tests are useful to predict ovarian response but whether AMH is a substantially better predictor is not yet established.
St. Michael's Hospital, University Hospital Bristol NHS Foundation Trust, Southwell Street Bristol, BS2 8EG, UK.
Munawar
M
Hussain
University of Bristol, St. Michael's Hospital, Bristol BS2 8EG, UK.
David
D
Cahill
Southmead Hospital, North Bristol NHS Trust & Bristol Centre for Reproductive Medicine Bristol, Southmead Road, Westbury-on-Trym, Bristol BS10 5NB, UK.
Valentine
V
Akande
Southmead Hospital, North Bristol NHS Trust & Bristol Centre for Reproductive Medicine Bristol, Southmead Road, Westbury-on-Trym, Bristol BS10 5NB, UK.
Uma
U
Gordon