Systematic study of high-frequency ultrasonic transducer design for laser-scanning photoacoustic ophthalmoscopy.
Photoacoustic ophthalmoscopy (PAOM) is a high-resolution in vivo imaging modality that is capable of providing specific optical absorption information for the retina. A high-frequency ultrasonic transducer is one of the key components in PAOM, which is in contact with the eyelid through coupling gel during imaging. The ultrasonic transducer plays a crucial role in determining the image quality affected by parameters such as spatial resolution, signal-to-noise ratio, and field of view. In this paper, we present the results of a systematic study on a high-frequency ultrasonic transducer design for PAOM. The design includes piezoelectric material selection, frequency selection, and the fabrication process. Transducers of various designs were successfully applied for capturing images of biological samples in vivo. The performances of these designs are compared and evaluated.
University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90033.
Teng
T
Ma
University of Southern California, Keck School of Medicine, Department of Ophthalmology, Los Angeles, California 90033.
Xiangyang
X
Zhang
University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90033.
Chi Tat
CT
Chiu
University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90033.
Ruimin
R
Chen
University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90033.
K
K
Kirk Shung
University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90033.
Qifa
Q
Zhou
University of Southern California, Department of Biomedical Engineering, Los Angeles, California 90033bUniversity of Southern California, Keck School of Medicine, Department of Ophthalmology, Los Angeles, California 90033.
Shuliang
S
Jiao
D000162:Acoustics / Q000295:instrumentation*; D000818:Animals; D003460:Crystallization; D003952:Diagnostic Imaging / Q000295:instrumentation; D004867:Equipment Design; D006801:Humans; D021621:Imaging, Three-Dimensional; D007834:Lasers; D008027:Light; D009887:Ophthalmoscopy / Q000379:methods*; D061088:Photoacoustic Techniques; D051381:Rats; D012160:Retina / Q000473:pathology; D015398:Signal Transduction; D059629:Signal-To-Noise Ratio; D014159:Transducers; D014465:Ultrasonics