Evaluation of calcium supplementation with algae (Lithothamnion muelleri) on metabolic and inflammatory parameters in mice fed a high refined carbohydrate-containing diet.
The aim of the present study was to evaluate the potential of calcium supplementation from Lithothamnium muelleri algae on metabolic and inflammatory parameters in mice with increased adiposity. Male mice were fed and divided during 8 weeks in: control (C), a high refined carbohydrate-containing diet (HC), HC diet supplemented with 1% of Lithothamnion muelleri algae (HC + A) and HC diet supplemented with 0.9% calcium carbonate (HC + C). Animals fed HC diet had increased body weight gain and adiposity, serum glucose and cholesterol, glucose intolerance and decreased insulin sensitivity, compared to control diet. However, the HC + A and HC + C groups did not prevent these aspects and were not able to change the CD14 + cells population in adipose tissue of animals fed HC diet. Calcium supplementation with Lithothamnium muelleri algae and calcium carbonate had no protective effect against the development of adiposity, metabolic and inflammatory alterations induced by HC diet.
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais , MG , Brasil .
Zélia
Z
Menezes-Garcia
Andrezza Fernanda
AF
Santiago
Ana Maria Caetano
AM
Faria
Marina Chaves
MC
Oliveira
Leida Maria
LM
Botion
Danielle Glória
DG
Souza
Mauro Martins
MM
Teixeira
Adaliene Versiani Matos
AV
Ferreira
D052436:Adipose Tissue, White / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D050154:Adiposity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D019440:Anti-Obesity Agents / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D001808:Blood Vessels / Q000276:immunology / Q000473:pathology; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000032:analysis / Q000302:isolation & purification; D002136:Calcium, Dietary / Q000032:analysis / Q000302:isolation & purification / Q000627:therapeutic use*; D002478:Cells, Cultured; D045424:Complex Mixtures / Q000737:chemistry / Q000627:therapeutic use*; D004040:Dietary Carbohydrates / Q000009:adverse effects; D019587:Dietary Supplements / Q000032:analysis; D005511:Food Handling; D018149:Glucose Intolerance / Q000209:etiology / Q000517:prevention & control; D007333:Insulin Resistance; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D009765:Obesity / Q000209:etiology / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D000461:Rhodophyta / Q000737:chemistry*; D017154:Stromal Cells / Q000276:immunology / Q000473:pathology; D015430:Weight Gain
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019440:Anti-Obesity Agents; D002136:Calcium, Dietary; D045424:Complex Mixtures; D004040:Dietary Carbohydrates; D002119:Calcium Carbonate
Algae; calcium supplementation; inflammation; metabolism; obesity