Intra-operative rectal washout with saline solution can effectively prevent anastomotic recurrence: a meta-analysis.
OBJECTIVE
Rectal washout with saline solution may theoretically prevent anastomotic recurrence in patients with resectable rectal cancer, although exact clinical effects have not yet been determined. In order to derive a more precise estimation of the relationship, the present meta-analysis was performed.


METHODS
Relevant studies were identified by a search of Medline, Embase and Google Website with no restrictions to September 1, 2013, and included in the systematic review and meta-analysis.


RESULTS
5 trials (642 participants) were included to assess the association between rectal washout with saline solution and anastomotic recurrence. The rate of anastomotic recurrence (AR) was 6.23% (40/642), with the pooled OR derived from the five studies being 0.32 (95 % CI=0.15-0.70, P=0.004). The pooled OR derived from the TME and radical resection subgroups were 0.72 (95%CI=0.16-3.12, P=0.66) and 0.51 (95%CI=0.13-1.96, P=0.32), respectively.


CONCLUSIONS
Results from this analysis show that intra-operative rectal washout with mere saline solution largely reduces the risk of anastomotic recurrences in patients with resectable rectal cancer.
Department of Centre of Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China E-mail : peijun1020@163.com.
Can
C
Zhou
Yu
Y
Ren
Ke
K
Wang
Jie
J
Liu
Jian-Jun
JJ
He
Pei-Jun
PJ
Liu
D006801:Humans; D007430:Intraoperative Care; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000601:surgery*; D012965:Sodium Chloride / Q000008:administration & dosage*; D007507:Therapeutic Irrigation
D012965:Sodium Chloride