Direct α-alkylation of ketones with alcohols in water.
The direct α-alkylation of ketones with alcohols has emerged as a new green protocol to construct C-C bonds with H2 O as the sole byproduct. In this work, a very simple and convenient Pd/C catalytic system for the direct α-alkylation of ketones with primary alcohols in pure water is developed. Based on this catalytic system, aqueous mixtures of dilute acetone, 1-butanol, and ethanol (mimicking ABE fermentation products) can be directly transformed into C5 -C11 or longer-chain ketones and alcohols, which are precursors to fuels.
CAS Key Laboratory of Bio-based Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101 (PR China), Fax: (+86) 532-80662724.
Guoqiang
G
Xu
Qiong
Q
Li
Jiange
J
Feng
Qiang
Q
Liu
Zuojun
Z
Zhang
Xicheng
X
Wang
Xiaoyun
X
Zhang
Xindong
X
Mu
D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D055772:Green Chemistry Technology; D007659:Ketones / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000438:Alcohols; D007659:Ketones; D014867:Water; D010165:Palladium; D002244:Carbon
alcohols; alkylations; aqueous-phase reforming; heterogeneous catalysis; ketones