Polyethylene glycol-phosphatidylethanolamine (PEG-PE)/vitamin E micelles for co-delivery of paclitaxel and curcumin to overcome multi-drug resistance in ovarian cancer.
The therapeutic potential of mixed micelles, made of PEG-PE and vitamin E co-loaded with curcumin and paclitaxel, was investigated against SK-OV-3 human ovarian adenocarcinoma along with its multi-drug resistant version SK-OV-3-paclitaxel-resistant (TR) cells in vitro and in vivo. The addition of curcumin at various concentrations did not significantly enhance the cytotoxicity of paclitaxel against SK-OV-3 in vitro. However, a clear synergistic effect was observed with the combination treatment against SK-OV-3TR in vitro. In vivo, this combination treatment produced a three-fold tumor inhibition with each of these cell lines. Our results indicate that such co-loaded mixed micelles could have significant clinical advantages for the treatment of resistant ovarian cancer.
Northeastern University, Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, 140 The Fenway, Room 236, 360 Huntington Avenue, Boston, MA 02115, United States.
Abraham H
AH
Abouzeid
Northeastern University, Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, 140 The Fenway, Room 236, 360 Huntington Avenue, Boston, MA 02115, United States.
Niravkumar R
NR
Patel
Northeastern University, Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, 140 The Fenway, Room 211/214, 360 Huntington Avenue, Boston, MA 02115, United States. Electronic address: V.Torchilin@neu.edu.
Vladimir P
VP
Torchilin
D000818:Animals; D045744:Cell Line, Tumor; D003474:Curcumin / Q000008:administration & dosage* / Q000378:metabolism; D018432:Drug Resistance, Multiple / Q000187:drug effects* / Q000502:physiology; D019008:Drug Resistance, Neoplasm / Q000187:drug effects / Q000502:physiology; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008823:Micelles; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000378:metabolism; D017239:Paclitaxel / Q000008:administration & dosage* / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000008:administration & dosage*; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage* / Q000378:metabolism; D023041:Xenograft Model Antitumor Assays / Q000379:methods
D008823:Micelles; D010714:Phosphatidylethanolamines; C067972:dioleoyl-N-(monomethoxypolyethylene glycol succinyl)phosphatidylethanolamine; D014810:Vitamin E; D011092:Polyethylene Glycols; D003474:Curcumin; D017239:Paclitaxel
Combination therapy; Curcumin; Mixed micelles; Multi-drug resistance; Nuclear factor-kappa B (NF-κB); Ovarian cancer