Vitamin-D supplementation in prediabetes reduced progression to type 2 diabetes and was associated with decreased insulin resistance and systemic inflammation: an open label randomized prospective study from Eastern India.
Vitamin-D supplementation in vitamin-D insufficient/deficient prediabetes individuals is associated with significantly lower progression to diabetes (6/55 vs. 13/49; p=0.04) and higher reversal to normoglycemia (23/55 vs. 10/49; p=0.02), associated with decreased insulin resistance and systemic inflammation (TNFα and IL6). Baseline vitamin-D and 2h blood glucose independently predicted progression to diabetes.
Department of Endocrinology & Metabolism, IPGMER & SSKM Hospital, 244 AJC Bose Road, Calcutta 700020, India. Electronic address: deepdutta2000@yahoo.com.
Deep
D
Dutta
Department of Biochemistry, IPGMER & SSKM Hospital, 244 AJC Bose Road, Calcutta 700020, India. Electronic address: prot.samim@gmail.com.
Samim Ali
SA
Mondal
Department of Biochemistry, IPGMER & SSKM Hospital, 244 AJC Bose Road, Calcutta 700020, India. Electronic address: schoudhuri6@gmail.com.
Subhadip
S
Choudhuri
Department of Endocrinology & Metabolism, IPGMER & SSKM Hospital, 244 AJC Bose Road, Calcutta 700020, India. Electronic address: i.maisnam@gmail.com.
Indira
I
Maisnam
Department of Biochemistry, IPGMER & SSKM Hospital, 244 AJC Bose Road, Calcutta 700020, India. Electronic address: abu.rinku@rediffmail.com.
Abu Hena
AH
Hasanoor Reza
Department of Biochemistry, IPGMER & SSKM Hospital, 244 AJC Bose Road, Calcutta 700020, India. Electronic address: bbasudev@rediffmail.com.
Basudeb
B
Bhattacharya
Department of Endocrinology & Metabolism, IPGMER & SSKM Hospital, 244 AJC Bose Road, Calcutta 700020, India. Electronic address: subhankar.chowdhury@gmail.com.
Subhankar
S
Chowdhury
Department of Endocrinology & Metabolism, IPGMER & SSKM Hospital, 244 AJC Bose Road, Calcutta 700020, India. Electronic address: satinath.mukhopadhyay@gmail.com.
Satinath
S
Mukhopadhyay
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000401:mortality / Q000517:prevention & control*; D019587:Dietary Supplements; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D007249:Inflammation / Q000188:drug therapy / Q000401:mortality / Q000517:prevention & control*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood / Q000188:drug therapy*; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate; D014807:Vitamin D / Q000008:administration & dosage*; D014808:Vitamin D Deficiency / Q000401:mortality / Q000517:prevention & control; D014815:Vitamins / Q000008:administration & dosage*
D001786:Blood Glucose; D014815:Vitamins; D014807:Vitamin D
Diabetes; Insulin resistance; Prediabetes; Systemic inflammation; Vitamin-D