An autopsy case of incipient Pick's disease: immunohistochemical profile of early-stage Pick body formation.
There is little immunohistochemical information about the early stage of Pick body formation, due to the extremely limited opportunities of studying Pick's disease at the incipient or subclinical stage. We report a 62-year-old man without any clinical manifestations of Pick's disease, who died of B-cell lymphoma of the brainstem. Post mortem examination revealed many Pick bodies without obvious neuronal loss mainly in the left frontal and temporal lobes. Three brains of patients with typical Pick's disease (disease duration: 7, 11 and 16 years) were also examined. Pick bodies were immunopositive for phosphorylated tau and 3-repeat tau, and less consistently for p62 in both incipient and typical cases. In the incipient case, borderline positivity for ubiquitin was evident in only a few Pick bodies, whereas in the typical cases many Pick bodies showed obvious positivity for ubiquitin. These findings suggest that Pick bodies are rarely ubiquitinated in the early stage of Pick body formation.
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Yasuo
Y
Miki
Fumiaki
F
Mori
Kunikazu
K
Tanji
Hidekachi
H
Kurotaki
Akiyoshi
A
Kakita
Hitoshi
H
Takahashi
Koichi
K
Wakabayashi
D000368:Aged; D002540:Cerebral Cortex / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000648:ultrastructure*; D020774:Pick Disease of the Brain / Q000473:pathology*; D016875:tau Proteins / Q000032:analysis / Q000276:immunology
D016875:tau Proteins
3-repeat tau; Pick body; Pick's disease; p62; ubiquitin