Live birth from previously vitrified oocytes, after trophectoderm biopsy, revitrification, and transfer of a euploid blastocyst.
Our objective is to describe a successful live birth from oocyte vitrification followed by thaw, fertilization, blastocyst culture, trophectoderm biopsy, vitrification, and subsequent thaw. Fifteen mature oocytes were frozen from a patient with uterine factor infertility. Thirteen oocytes survived the thaw, and five underwent trophectoderm biopsy and were refrozen. Three euploid embryos were obtained. A single euploid embryo was transferred in the second thaw cycle to a known recipient leading to the delivery of a normal male infant. This case report is proof of the concept that preimplantation screening and diagnosis is an option for fertility preservation patients.
The NYU Fertility Center, NYU Langone Medical Center, New York, New York, USA.
Jamie A
JA
Grifo
The NYU Fertility Center, NYU Langone Medical Center, New York, New York, USA.
Brooke
B
Hodes-Wertz
The NYU Fertility Center, NYU Langone Medical Center, New York, New York, USA.
Hsiao Ling
HL
Lee
The NYU Fertility Center, NYU Langone Medical Center, New York, New York, USA.
Esmeralda
E
Ampeloquio
The NYU Fertility Center, NYU Langone Medical Center, New York, New York, USA.
Melicia
M
Clarke-Williams
The NYU Fertility Center, NYU Langone Medical Center, New York, New York, USA.
Alexis
A
Adler
The NYU Fertility Center, NYU Langone Medical Center, New York, New York, USA.
Santiago
S
Munné
The NYU Fertility Center, NYU Langone Medical Center, New York, New York, USA.
Alan S
AS
Berkeley
array comparative genomic hybridization; embryo biopsy; fertility preservation; oocyte cryopreservation; preimplantation genetic diagnosis; trophectoderm biopsy