Reward inference by primate prefrontal and striatal neurons.
The brain contains multiple yet distinct systems involved in reward prediction. To understand the nature of these processes, we recorded single-unit activity from the lateral prefrontal cortex (LPFC) and the striatum in monkeys performing a reward inference task using an asymmetric reward schedule. We found that neurons both in the LPFC and in the striatum predicted reward values for stimuli that had been previously well experienced with set reward quantities in the asymmetric reward task. Importantly, these LPFC neurons could predict the reward value of a stimulus using transitive inference even when the monkeys had not yet learned the stimulus-reward association directly; whereas these striatal neurons did not show such an ability. Nevertheless, because there were two set amounts of reward (large and small), the selected striatal neurons were able to exclusively infer the reward value (e.g., large) of one novel stimulus from a pair after directly experiencing the alternative stimulus with the other reward value (e.g., small). Our results suggest that although neurons that predict reward value for old stimuli in the LPFC could also do so for new stimuli via transitive inference, those in the striatum could only predict reward for new stimuli via exclusive inference. Moreover, the striatum showed more complex functions than was surmised previously for model-free learning.
Institute for Cognitive Neurodynamics, East China University of Science and Technology, Shanghai 200237, China, Brain Science Institute, Tamagawa University, Machida, Tokyo 194-8610, Japan, Department of Psychology, Senshu University, Tama-ku, Kawasaki, Kanagawa 214-8580, Japan, and Research Institute for Electronic Science, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan.
Xiaochuan
X
Pan
Hongwei
H
Fan
Kosuke
K
Sawa
Ichiro
I
Tsuda
Minoru
M
Tsukada
Masamichi
M
Sakagami
D000818:Animals; D003342:Corpus Striatum / Q000502:physiology*; D000882:Haplorhini; D007858:Learning / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000502:physiology; D018408:Patch-Clamp Techniques; D017397:Prefrontal Cortex / Q000502:physiology*; D012201:Reward
inference; model-based learning; model-free learning; prefrontal cortex; reward; striatum