Lymphocytic choriomeningitis virus in employees and mice at multipremises feeder-rodent operation, United States, 2012.
We investigated the extent of lymphocytic choriomeningitis virus (LCMV) infection in employees and rodents at 3 commercial breeding facilities. Of 97 employees tested, 31 (32%) had IgM and/or IgG to LCMV, and aseptic meningitis was diagnosed in 4 employees. Of 1,820 rodents tested in 1 facility, 382 (21%) mice (Mus musculus) had detectable IgG, and 13 (0.7%) were positive by reverse transcription PCR; LCMV was isolated from 8. Rats (Rattus norvegicus) were not found to be infected. S-segment RNA sequence was similar to strains previously isolated in North America. Contact by wild mice with colony mice was the likely source for LCMV, and shipments of infected mice among facilities spread the infection. The breeding colonies were depopulated to prevent further human infections. Future outbreaks can be prevented with monitoring and management, and employees should be made aware of LCMV risks and prevention.
Barbara
B
Knust
Ute
U
Ströher
Laura
L
Edison
César G
CG
Albariño
Jodi
J
Lovejoy
Emilian
E
Armeanu
Jennifer
J
House
Denise
D
Cory
Clayton
C
Horton
Kathy L
KL
Fowler
Jessica
J
Austin
John
J
Poe
Kraig E
KE
Humbaugh
Lisa
L
Guerrero
Shelley
S
Campbell
Aridth
A
Gibbons
Zachary
Z
Reed
Deborah
D
Cannon
Craig
C
Manning
Brett
B
Petersen
Douglas
D
Metcalf
Bret
B
Marsh
Stuart T
ST
Nichol
Pierre E
PE
Rollin
D000328:Adult; D000822:Animal Husbandry; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008216:Lymphocytic Choriomeningitis / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D008217:Lymphocytic choriomeningitis virus / Q000145:classification* / Q000235:genetics; D008297:Male; D008582:Meningitis, Aseptic / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D051379:Mice; D016273:Occupational Exposure; D010802:Phylogeny; D012367:RNA, Viral / Q000145:classification* / Q000235:genetics; D051381:Rats; D012703:Serotyping; D014481:United States / Q000453:epidemiology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012367:RNA, Viral
Indiana; Lymphocytic choriomeningitis virus; United States; aseptic meningitis; occupational health; rodent-borne disease; viral meningitis; viruses; zoonotic disease