Oxidative stress increased in pregnant women with iodine deficiency.
Iodine is an essential element trace for the synthesis of maternal thyroid hormones needed to support normal fetal development; it also acts as an antioxidant directly or induce antioxidant enzymes indirectly. Iodine deficiency and oxidative stress are associated with pregnancy complications. This study aimed to assess the urinary iodine concentration and its relationship with the antioxidant and oxidative stress status during gestation. Pregnant women were consecutively recruited from an obstetric clinic during all gestation trimesters, and urinary iodine concentration, antioxidant, and oxidative stress were determined. Results showed that 70 % of pregnant women have optimal iodine levels (150-200 μg/L), while approximately 30 % showed mild iodine deficiency (50-99 μg/L). Oxidative stress was significantly higher, and the antioxidant status was also compromised as evidenced by decreased total antioxidant status and superoxide dismutase (SOD) activity in pregnant women with mild iodine deficiency than pregnant women with optimal iodine levels. Significant positive correlations were noted between optimal iodine levels and total antioxidant status. Oxidative stress was significantly correlated with mild iodine deficiency. However, no significant correlation was found between iodine levels and SOD and catalase activities. In conclusion, for the first time, these data suggest a correlation between iodine levels and the antioxidant status during pregnancy.
Instituto de Salud Pública, Universidad Veracruzana, Avenida Luís Castelazo Ayala S/N, Col. Industrial Ánimas, Xalapa, Veracruz, México.
Zendy Evelyn Olivo
ZE
Vidal
Sergio Cuellar
SC
Rufino
Esteban Hernández
EH
Tlaxcalteco
Cirenia Hernández
CH
Trejo
Raúl Martínez
RM
Campos
Mónica Navarro
MN
Meza
Rocío Coutiño
RC
Rodríguez
Omar
O
Arroyo-Helguera
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007455:Iodine / Q000172:deficiency* / Q000378:metabolism / Q000652:urine; D008875:Middle Aged; D018384:Oxidative Stress; D011247:Pregnancy; D011248:Pregnancy Complications / Q000201:enzymology / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D055815:Young Adult
D000975:Antioxidants; D007455:Iodine; D013482:Superoxide Dismutase