Protein microcapsules: preparation and applications.
Liposomes and polymerosomes generally represent the two most widely used carriers for encapsulating compounds, in particular drugs for delivery. While these are well established carriers, recent applications in biomedicine and food industry have necessitated the use of proteins as robust carriers that are stable under extreme acidic and basic conditions, have practically no toxicity and are able to withstand high shear force. This review highlights the different methods for using proteins as encapsulating materials and lists some biomedical applications of the microcapsules. The advantages and limitations in the capsules from the different preparation routes are enumerated.
Chemical Lab., CSIR-CLRI, Adyar, Chennai 600020, India.
Maheshkumar
M
Jaganathan
Biophysics Lab., CSIR-CLRI, Adyar, Chennai 600020, India.
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D
Madhumitha
Biophysics Lab., CSIR-CLRI, Adyar, Chennai 600020, India.
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A
Dhathathreyan
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D002214:Capsules / Q000737:chemistry; D002417:Cattle; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods; D004396:Coloring Agents / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D004337:Drug Carriers; D015195:Drug Design; D004573:Electrolytes; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry
D001672:Biocompatible Materials; D002214:Capsules; D004396:Coloring Agents; D004337:Drug Carriers; D004573:Electrolytes; D008081:Liposomes; D011108:Polymers; D011506:Proteins; D012710:Serum Albumin, Bovine; D004247:DNA
Biomedicine; Capsules; Covalent; Multicore; Multiwalled; Non covalent; Protein