Synthesis of a miniature lipoarabinomannan.
An analog of Mycobacterium tuberculosis lipoarabinomannan (LAM) has been synthesized containing the characteristic structures of all of its three major components; that is, a mannosylated phosphatidylinositol moiety, an oligomannan, and an oligoarabinan. A highly convergent strategy was developed that is applicable to the synthesis of other LAM analogs. The synthetic miniature LAM should be useful for various biological studies.
Department of Chemistry, Wayne State University , Detroit, Michigan 48202, United States.
Jian
J
Gao
Guochao
G
Liao
Lizhen
L
Wang
Zhongwu
Z
Guo
D008070:Lipopolysaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000737:chemistry* / Q000276:immunology; D009844:Oligosaccharides / Q000737:chemistry*; D010716:Phosphatidylinositols / Q000737:chemistry*
D008070:Lipopolysaccharides; D009844:Oligosaccharides; D010716:Phosphatidylinositols; C050016:lipoarabinomannan