The shape of things to come.
Surface receptors can link binding of ligands to changes in the actin-based cell cytoskeleton. Chia et al. and Chen et al. provide evidence for direct binding between the cytoplasmic tails of receptors and the WAVE complex, a regulator of the actin nucleator Arp2/3 complex, which might help to explain how environmental signals are translated into changes in morphology and motility.
Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: lzipursky@mednet.ucla.edu.
S Lawrence
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Zipursky
D008841:Actin Cytoskeleton / Q000378:metabolism*; D000199:Actins / Q000378:metabolism*; D000818:Animals; D001369:Axons / Q000378:metabolism*; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D008565:Membrane Proteins / Q000737:chemistry*; D046912:Multiprotein Complexes / Q000737:chemistry*; D013569:Synapses / Q000378:metabolism*; D051300:Wiskott-Aldrich Syndrome Protein Family / Q000737:chemistry*
D000199:Actins; D029742:Caenorhabditis elegans Proteins; D007136:Immunoglobulins; D008565:Membrane Proteins; D046912:Multiprotein Complexes; C473474:SYG-1 protein, C elegans; D051300:Wiskott-Aldrich Syndrome Protein Family