Antipsychotic dosing: found in translation.
In the field of schizophrenia research, as in other areas of psychiatry, there is a sense of frustration that greater advances have not been made over the years, calling into question existing research strategies. Arguably, many purported gains claimed by research have been "lost in translation," resulting in limited impact on diagnosis and treatment in the clinical setting. There are exceptions; for example, we would argue that different lines of preclinical and clinical research have substantially altered how we look at antipsychotic dosing. While this story remains a work in progress, advances "found in translation" have played an important role. Detailing these changes, the present paper speaks to a body of evidence that has already shifted clinical practice and raises questions that may further alter the manner in which antipsychotics have been administered over the last 6 decades.
The Department of Psychiatry, University of Toronto, Toronto, Ont., Institute of Medical Science, University of Toronto, Toronto, Ont., Centre for Addiction and Mental Health (CAMH), Toronto, Ont., and The Campbell Family Mental Health Research Institute, Toronto, Ont., Canada.
Gary
G
Remington
Institute of Medical Science, University of Toronto, Toronto, Ont.
Gagan
G
Fervaha
The Department of Psychiatry, University of Toronto, Toronto, Ont., Institute of Medical Science, University of Toronto, Toronto, Ont., and The Centre for Addiction and Mental Health (CAMH), Toronto, Ont.
George
G
Foussias
The Department of Psychiatry, University of Toronto, Toronto, Ont., Institute of Medical Science, University of Toronto, Toronto, Ont., and The Centre for Addiction and Mental Health (CAMH), Toronto, Ont.
Ofer
O
Agid
Institute of Medical Science, University of Toronto, Toronto, Ont.
Peter
P
Turrone
D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D011600:Psychopharmacology; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents