Novel paramyxovirus associated with severe acute febrile disease, South Sudan and Uganda, 2012.
In 2012, a female wildlife biologist experienced fever, malaise, headache, generalized myalgia and arthralgia, neck stiffness, and a sore throat shortly after returning to the United States from a 6-week field expedition to South Sudan and Uganda. She was hospitalized, after which a maculopapular rash developed and became confluent. When the patient was discharged from the hospital on day 14, arthralgia and myalgia had improved, oropharynx ulcerations had healed, the rash had resolved without desquamation, and blood counts and hepatic enzyme levels were returning to reference levels. After several known suspect pathogens were ruled out as the cause of her illness, deep sequencing and metagenomics analysis revealed a novel paramyxovirus related to rubula-like viruses isolated from fruit bats.
César G
CG
Albariño
Michael
M
Foltzer
Jonathan S
JS
Towner
Lory A
LA
Rowe
Shelley
S
Campbell
Carlos M
CM
Jaramillo
Brian H
BH
Bird
DeeAnn M
DM
Reeder
Megan E
ME
Vodzak
Paul
P
Rota
Maureen G
MG
Metcalfe
Christina F
CF
Spiropoulou
Barbara
B
Knust
Joel P
JP
Vincent
Michael A
MA
Frace
Stuart T
ST
Nichol
Pierre E
PE
Rollin
Ute
U
Ströher
D000208:Acute Disease; D000328:Adult; D000818:Animals; D002685:Chiroptera / Q000821:virology*; D005260:Female; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D058977:Molecular Sequence Annotation; D018184:Paramyxoviridae Infections / Q000473:pathology / Q000635:transmission / Q000821:virology*; D018098:Paramyxovirinae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D010802:Phylogeny; D012367:RNA, Viral / Q000145:classification* / Q000235:genetics; D013397:Sudan; D014195:Travel; D014454:Uganda
D012367:RNA, Viral
Paramyxoviridae; Sosuga virus; South Sudan; Uganda; bats; diagnostics; metagenomics; rash; rubula-like virus; viruses; zoonosis