One-step fabrication of agent-loaded biodegradable microspheroids for drug delivery and imaging applications.
Non-spherical particles may offer advantages over conventional spherical systems for drug delivery applications. This work describes the fabrication of agent-loaded poly(lactic-co-glycolic acid) (PLGA) spheroids via the emulsion solvent evaporation (ESE) method. The versatility of this technique for loading a variety of therapeutics is demonstrated via loading of paclitaxel, bovine serum albumin, and cadmium sulfide nanoparticles into PLGA spheroids. The encapsulation efficiency for spheroids fabricated via oil-in-water (O/W) emulsions is highest at low aqueous phase surfactant concentrations while the encapsulation efficiency for spheroids made via water-in-oil-in-water (W/O/W) is highest at high aqueous phase surfactant concentrations and basic aqueous phase pH values. Particle aspect ratio polydispersity can be minimized via the use of high aqueous phase PVA concentration and pH. The ESE technique is an attractive alternative to recently described methods for fabrication of non-spherical particles due to its simplicity in setup, high particle yield and adaptability to a variety of biodegradable polymers and therapeutics.
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Michael J
MJ
Heslinga
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Gabriella M
GM
Willis
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Daniel J
DJ
Sobczynski
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Alex J
AJ
Thompson
Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: lolaa@umich.edu.
Omolola
O
Eniola-Adefeso
D000818:Animals; D019187:Cadmium Compounds / Q000737:chemistry; D002417:Cattle; D016503:Drug Delivery Systems; D004655:Emulsions / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000737:chemistry*; D057054:Molecular Imaging; D053758:Nanoparticles / Q000737:chemistry; D009821:Oils / Q000737:chemistry; D017239:Paclitaxel / Q000737:chemistry; D011100:Polyglycolic Acid / Q000138:chemical synthesis* / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry; D014867:Water / Q000737:chemistry
D019187:Cadmium Compounds; D004655:Emulsions; D009821:Oils; D013440:Sulfides; C034939:cadmium sulfide; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D012710:Serum Albumin, Bovine; D019344:Lactic Acid; D017239:Paclitaxel
Microparticles; Nanoparticles; Non-spherical drug carrier; Poly(lactic-co-glycolic acid); Solvent evaporation; Vascular-targeted carriers