Effects of short-term niacin treatment on plasma lipoprotein concentrations in African green monkeys (Chlorocebus aethiops).
Niacin is the most effective drug available for raising levels of high-density lipoprotein (HDL) cholesterol. To evaluate its effects on plasma lipid concentrations, the authors administered a low dose of niacin to healthy, adult, female African green monkeys for 3 months. In the treated monkeys, low-density lipoprotein cholesterol concentrations decreased by 43% from baseline, whereas concentrations of HDL cholesterol and apolipoprotein A-I increased by 49% and 34%, respectively. The results suggest that in this primate model, a low dose of niacin can effectively increase concentrations of HDL cholesterol.
Medical Research Council Primate Unit, Tygerberg, South Africa.
Chesa G
CG
Chauke
Biotechnology Department, University of the Western Cape, Cape Town, South Africa.
Zainunisha
Z
Arieff
1] Biotechnology Department, University of the Western Cape, Cape Town, South Africa. [2] Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.
Mandeep
M
Kaur
Medical Research Council Primate Unit, Tygerberg, South Africa.
Jurgen V
JV
Seier
D000704:Analysis of Variance; D000818:Animals; D016632:Apolipoprotein A-I / Q000097:blood* / Q000187:drug effects; D001835:Body Weight; D002522:Chlorocebus aethiops; D008076:Cholesterol, HDL / Q000097:blood* / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood* / Q000187:drug effects; D004195:Disease Models, Animal; D005260:Female; D009525:Niacin / Q000008:administration & dosage / Q000494:pharmacology*; D013045:Species Specificity
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D009525:Niacin