Association between a single nucleotide polymorphism of the XRCC1 gene and hepatocellular carcinoma susceptibility in the Chinese Han population.
The human X-ray repair cross-complementing protein 1 (XRCC1) gene is a potentially gene determining hepatocellular carcinoma (HCC) susceptibility. The purpose of this study was to evaluate the association between XRCC1 and susceptibility to HCC. The association of XRCC1 polymorphisms with HCC susceptibility was investigated in 460 HCC patients and 463 controls using the created restriction site-polymerase chain reaction method. Our results indicate that the c.1471G>A variant could be detected and that the allele and genotype frequencies were statistically different between cases and controls. The AA genotype was strongly associated with increased HCC susceptibility as compared with the GG wild genotype (OR = 2.214, 95%CI = 1.493-3.283, χ(2) = 15.97, P < 0.0001). In addition, significantly increased HCC susceptibility was also found in a dominant and recessive model (P < 0.01). The allele A could contribute to HCC susceptibility compared with the G allele (OR = 1.480, 95%CI = 1.224-1.789, χ(2) = 16.44, P = 0.0001). Results from this study indicate that the XRCC1 c.1471G>A polymorphism is associated with HCC susceptibility in the Chinese Han population. Future studies on larger populations are essential to confirm this association.
Department of Infectious Diseases, the Yiwu Central Hospital, Yiwu, Zhejiang Province, China.
X F
XF
Li
Department of Infectious Diseases, the Yiwu Central Hospital, Yiwu, Zhejiang Province, China.
Y X
YX
Chen
Department of Infectious Diseases, the Yiwu Central Hospital, Yiwu, Zhejiang Province, China.
W W
WW
Ye
Department of Infectious Diseases, the Yiwu Central Hospital, Yiwu, Zhejiang Province, China.
X F
XF
Tao
Department of Infectious Diseases, the Yiwu Central Hospital, Yiwu, Zhejiang Province, China.
J H
JH
Zhu
Department of Infectious Diseases, the Yiwu Central Hospital, Yiwu, Zhejiang Province, China.
S
S
Wu
Department of Infectious Diseases, the Yiwu Central Hospital, Yiwu, Zhejiang Province, China lianqinglou@sina.com.
L Q
LQ
Lou
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D000076105:X-ray Repair Cross Complementing Protein 1
D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human