InFLUencing host survival: cIAP2 tips the scales.
Necroptosis has emerged as an important facet of both host defense and inflammatory disease. In this issue, Rodrigue-Gervais et al. (2014) demonstrate a role for the cell death regulator cIAP2 in maintaining lung homeostasis during influenza infection. Loss of cIAP2 promotes necroptosis of lung tissues, leading to host death.
Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2506 Speedway, Stop A5000, Austin, TX 78712-1191, USA. Electronic address: upton@austin.utexas.edu.
Jason W
JW
Upton
Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2506 Speedway, Stop A5000, Austin, TX 78712-1191, USA.
Haripriya
H
Sridharan
D000818:Animals; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D051034:Inhibitor of Apoptosis Proteins / Q000276:immunology*; D008168:Lung / Q000276:immunology*; D009336:Necrosis / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000276:immunology*; D020545:Respiratory Mucosa / Q000276:immunology*; D044767:Ubiquitin-Protein Ligases
D051034:Inhibitor of Apoptosis Proteins; D000075747:Baculoviral IAP Repeat-Containing 3 Protein; C494835:Birc3 protein, mouse; D044767:Ubiquitin-Protein Ligases; D053422:Receptor-Interacting Protein Serine-Threonine Kinases; C485615:Ripk3 protein, mouse