Effects of partial desulfation on antioxidant and inhibition of DLD cancer cell of Ulva fasciata polysaccharide.
Ulva fasciata belonging to the family Ulvaceae, commonly known as 'sea lettuce', is an abundantly growing green seaweed in coastal seashore of South China. Three different molecular weight sulfated polysaccharides (UFP1, UFP2 and UFP3) were extracted and separated from U. fasciata by hot water extraction and ultrafiltration. The three native UFP fractions had partial desulfurization by solvolytic desulfation respectively and the effect of sulfate content on the exhibition of the antioxidant and anti-tumor capacities had been evaluated and compared. The results showed that each native polysaccharide (UFP1, UFP2, UFP3) with high sulfate content exhibited better antioxidant activities compared with the partial desulfated polysaccharides (DS-UFP1, DS-UFP2, DS-UFP3). Specifically, UFP2 with relatively high sulfate content, molecular weight and uronic acid content had consistently excellent antioxidant performances. However, UFP2 demonstrated the minimal inhibitory effects on growth of DLD intestinal cancer cells. Instead, DS-UFP3 with the lowest sulfate content but highest uronic acid content and molecular weight exhibited the best antitumor activity.
Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China.
Ping
P
Shao
Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China.
Yaping
Y
Pei
School of Public Health, Curtin Health Innovation Research Institute, International Institute of Agri-Food Security, Curtin University, GPO Box U1987, Perth, WA 6845, Australia.
Zhongxian
Z
Fang
Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, PR China. Electronic address: sunpl1964@163.com.
Peilong
P
Sun
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology; D005609:Free Radicals / Q000737:chemistry; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology*; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013431:Sulfates / Q000737:chemistry*; D044445:Ulva / Q000737:chemistry*
D000970:Antineoplastic Agents; D016166:Free Radical Scavengers; D005609:Free Radicals; D011134:Polysaccharides; D013431:Sulfates
Activity; Partial desulfation; Ulva fasciata polysaccharides