Characteristics of sebaceous carcinoma and early outcomes of treatment using Mohs micrographic surgery versus wide local excision: an update of the Mayo Clinic experience over the past 2 decades.
BACKGROUND
Sebaceous carcinoma (SC) is a rare cutaneous neoplasm.


OBJECTIVE
To characterize SC and treatment approaches and outcomes.


METHODS
We retrospectively reviewed records of patients with SC from 1992 through 2012. Recurrence-free survival was estimated and compared between groups.


RESULTS
We identified 52 patients with SC (39, 75.0% male). Mean age ± standard deviation at diagnosis was 72.7 ± 10.8. Forty-nine patients (94.2%) were white. Twenty-one (of 29 with known status) had a diagnosis of Muir-Torre syndrome. Six had multiple primary SCs (total of 73 SCs in 52 patients). The most common locations for SC were the back (20.5%), cheek (13.7%), nose (11.0%), and eye (9.6%). Treatment was recorded for 70 SCs; 35 (50.0%) were treated using Mohs micrographic surgery (MMS) and 26 (37.1%) using wide local excision (WLE). Of the 45 patients (66 SCs) with clinical follow-up, three (6.7% of patients; 4.8% of SCs) had documented recurrence.


CONCLUSIONS
MMS and WLE are effective treatments for SC. Further research is warranted to determine whether one treatment is more efficacious than the other.
College of Medicine, Mayo Medical School, Rochester, Minnesota.
Jennifer L
JL
Hou
Jill M
JM
Killian
Christian L
CL
Baum
Clark C
CC
Otley
Randall K
RK
Roenigk
Christopher J
CJ
Arpey
Amy L
AL
Weaver
Jerry D
JD
Brewer
D018266:Adenocarcinoma, Sebaceous / Q000473:pathology / Q000601:surgery*; D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D015580:Mohs Surgery; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome