Treatment of multiple solitary plasmacytomas with cytokine-induced killer cells.
OBJECTIVE
Currently available treatment methods for advanced plasmacytoma include surgery, chemotherapy, radiotherapy, immunomodulatory agents, hematopoietic stem cell transplantation and donor lymphocyte infusion. We report a case of advanced refractory multiple solitary plasmacytomas in a 68-year-old Asian man with multiple bone lesions, in whom autologous cytokine-induced killer (CIK) cells were administered in an effort to eliminate residual tumor lesions.


METHODS
CIK cells were infused monthly for 21 courses.


RESULTS
The patient has survived 63 months since the first hospital visit without disease progression for 40 months.


CONCLUSIONS
This case represents the first report of autologous CIK cell immunotherapy used successfully to suppress multiple solitary plasmacytomas and resolve bone lesions.
Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China.
Bo
B
Yang
Department of Cadre Health Care, Chinese PLA Navy General Hospital, Beijing, China.
Ji
J
Wang
Department of Geriatric Laboratory Medicine, Chinese PLA General Hospital, Beijing, China.
Li-Li
LL
Cai
Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China.
Hong-Li
HL
Zhu
Institute of Otorhinolaryngology, Chinese PLA General Hospital, Beijing, China.
Rui-Li
RL
Yu
Department of Pharmacy, the Second Artillery General Hospital, Beijing, China.
Xiao-Hua
XH
Chi
Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China. Electronic address: luxuechun@126.com.
Xue-Chun
XC
Lu
D000368:Aged; D044466:Asian People; D001859:Bone Neoplasms / Q000276:immunology / Q000628:therapy*; D019496:Cancer Vaccines; D055612:Cytokine-Induced Killer Cells / Q000276:immunology / Q000637:transplantation*; D018572:Disease-Free Survival; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D010954:Plasmacytoma / Q000276:immunology / Q000628:therapy*; D014182:Transplantation, Autologous
D019496:Cancer Vaccines
cancer; chemotherapy; cytokine-induced killer cells; immunotherapy; plasmacytoma