Evaluation of the antipsychotic potential of aqueous fraction of Securinega virosa root bark extract in mice.
Securinega virosa (Roxb ex. Willd) Baill. is a plant which is commonly used in African traditional medicine in management of mental illness. Previous study showed that the crude methanolic root bark extract of the plant possesses antipsychotic activity. In this study, the antipsychotic potential of the residual aqueous fraction of the plant was evaluated using two experimental models, apomorphine induced stereotypic climbing behaviour and swim induced grooming, all in mice. The effect of the fraction on haloperidol-induced catalepsy was also evaluated. The fraction significantly reduced the mean climbing score at the highest dose tested (500 mg/kg). In the swim-induced grooming test, the fraction significantly and dose-dependently (125-500 mg/kg) decreased the mean number and mean duration of swim-induced grooming activity in mice. Similarly, the standard haloperidol (1 mg/kg) significantly (p < 0.001) decreased the mean grooming episodes and duration. However, the fraction did not significantly potentiate haloperidol-induced catalepsy. These results suggest that the residual aqueous fraction of methanol root bark extract of Securinega virosa contains biological active principle with antipsychotic potential.
Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria, magmas1@yahoo.com.
M G
MG
Magaji
M
M
Mohammed
R A
RA
Magaji
A M
AM
Musa
I
I
Abdu-Aguye
I M
IM
Hussaini
D000818:Animals; D014150:Antipsychotic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D001058:Apomorphine / Q000633:toxicity; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D019665:Euphorbiaceae; D005260:Female; D006120:Grooming / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology / Q000633:toxicity; D008297:Male; D016488:Medicine, African Traditional; D000432:Methanol; D051379:Mice; D008517:Phytotherapy; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000627:therapeutic use*; D018517:Plant Roots / Q000737:chemistry*; D012997:Solvents; D013239:Stereotyped Behavior / Q000187:drug effects; D013550:Swimming; D014867:Water
D014150:Antipsychotic Agents; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D006220:Haloperidol; D001058:Apomorphine; D000432:Methanol