Present status and future challenges of electroencephalography- and magnetic resonance imaging-based monitoring in preclinical models of focal cerebral ischemia.
Animal models are useful tools for better understanding the mechanisms underlying neurological deterioration after an ischemic insult as well as subsequent evolution of changes and recovery of functions. In response to the updated requirements for preclinical investigations of stroke to include relevant functional measurement techniques and biomarker endpoints, we here review the state of knowledge on application of some translational electrophysiological and neuroimaging methods, and in particular, electroencephalography monitoring and magnetic resonance imaging in rodent models of ischemic stroke. This may lead to improvement of diagnostic methods and identification of new therapeutic targets, which would considerably advance the translational value of preclinical stroke research.
Neuropharmacology Unit, I.R.C.C.S. Istituto Neurologico Mediterraneo NEUROMED, Pozzilli, Italy. Electronic address: slavmoy13@gmail.com.
Slavianka G
SG
Moyanova
Biomedical MR Imaging & Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Radiology, Molecular Imaging Program at Stanford, Stanford University School of Medicine, Stanford, CA, United States.
Rick M
RM
Dijkhuizen
D000818:Animals; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D002545:Brain Ischemia / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods*; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D020521:Stroke / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology
EEG; Focal models of stroke; MR imaging; Rodents