[Metabolic syndrome is associated with cardiovascular events in haemodialysis].
BACKGROUND
Metabolic syndrome (MS) is a cardiovascular risk factor and is associated with mortality in the general population and in patients with chronic kidney disease. However, few studies have been carried out in patients on haemodialysis (HD).


OBJECTIVE
The objective of the study is to analyse the effect of MS on the occurrence of cardiovascular events in HD. The secondary objective is to determine the influence of the fat tissue index and conicity index on cardiovascular events.


METHODS
A prospective study including 100 patients on HD. The follow-up period was 3 years. Cardiovascular events and mortality were recorded. MS was defined in accordance with ATPIII and IDF criteria.


RESULTS
MS prevalence as defined by the ATPIII was 32%, and by the IDF, 29%. The concordance between the two definitions was high (kappa index 0.79, 95% confidence interval 0.65 to 0.92). The risk of cardiovascular events was higher in patients with MS (Log Rank 6.185, p = 0.013), with a fat tissue index greater than 11.5 kg/m(2) (log rank 10.220, p=.001) and a conicity index greater than 1.2 (log rank 6.393, p=.011). In the Cox analysis, adjusted for age and sex, patients with MS had twice the risk of being admitted due to a cardiovascular event (odds ratio 1.93, 1.022 to 3.6, p=.043). Mortality was 35% in the 3 year follow-up period with no differences between the groups with and without MS.


CONCLUSIONS
MS is a very prevalent disease in HD patients and its presence doubles the risk of hospitalisation due to cardiovascular events in the short term.
Ana
A
Pérez de José
Úrsula
Ú
Verdalles-Guzmán
Soraya
S
Abad
Almudena
A
Vega
Javier
J
Reque
Nayara
N
Panizo
Abrahan
A
Rincón
Claudia
C
Yuste
David
D
Arroyo
Juan M
JM
López-Gómez
D000368:Aged; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis