Severe acute renal failure in patients treated with glucagon-like peptide-1 receptor agonists.
We report two patients with diabetes in whom acute renal failure requiring hemodialysis occurred while on treatment with glucagon-like peptide-1 receptor agonists. We discuss the mechanisms of this complication and the potential for its prevention.
Department of Immunology and Diabetology, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: daniele.dubois@cch.aphp.fr.
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Dubois-Laforgue
Department of Immunology and Diabetology, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
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Boutboul
Department of Immunology and Diabetology, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
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Lévy
Department of Nephrology, Hôpital Necker, 149 rue de Sèvres, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
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Joly
Department of Immunology and Diabetology, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
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Timsit
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000009:adverse effects*; D000067757:Glucagon-Like Peptide-1 Receptor; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018027:Receptors, Glucagon / Q000819:agonists*; D006435:Renal Dialysis
C000593833:GLP1R protein, human; D000067757:Glucagon-Like Peptide-1 Receptor; D007004:Hypoglycemic Agents; D018027:Receptors, Glucagon; D052216:Glucagon-Like Peptide 1
Acute interstitial nephritis; Acute renal failure; Exenatide; Glucagon-like peptide-1 receptor agonists; Liraglutide; Type 2 diabetes mellitus