Meta-analysis of the association between common interleukin-1 polymorphisms and dental implant failure.
Interleukin-1 (IL) plays a pivotal role in immune-inflammatory response that maintains periodontal homeostasis. A number of epidemiological studies have been conducted to investigate the associations between common polymorphisms of IL-1 (IL-1A, IL-1B) genes and risk of peri-implant disease, but the findings remain inconclusive. Thirteen studies evaluating the association between IL-1 polymorphisms and risk for peri-implant diseases (implant failure/loss, peri-implantitis) were included. Fixed model or random-effects models were applied to calculate overall and ethnicity-specific summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) as risk estimates for IL-1 polymorphisms individually or in combination. Heterogeneity and publication bias were evaluated by Q-test, I2 statistic, Begg's funnel plot and Egger's test accordingly. The composite genotype of IL-1A (-889) and IL-1B (+3954) was associated with increased risk of implant failure/loss (OR 1.76, 95% CI 1.21-2.57) and peri-implantitis (OR 2.34, 95% CI 1.03-5.33). The significance was borderline in European descents (implant failure/loss: OR 1.48, 95% CI 0.99-2.22; peri-implantitis: OR 1.65, 95% CI 1.00-2.73). T allele of IL-1B (-511) was associated with increased risk of implant failure/loss (OR 1.28, 95% CI 1.01-1.62), while the association was not significant in European descents (OR 1.12, 95% CI 0.85-1.48). These findings support a potential role of IL-1 polymorphisms, particularly the composite genotype of IL-1A (-889) and IL-1B (+3954), in peri-implant disease susceptibility. More studies with large sample size are needed to validate the associations.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section of Ren Min Nan Rd, Chengdu, People's Republic of China.
Jian
J
Liao
Chao
C
Li
Yong
Y
Wang
MinHua
M
Ten
Xu
X
Sun
Ai
A
Tian
Qi
Q
Zhang
Xing
X
Liang
D000483:Alleles; D003757:Dental Implantation / Q000009:adverse effects; D015921:Dental Implants / Q000009:adverse effects; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D053582:Interleukin-1alpha / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D016017:Odds Ratio; D010510:Periodontal Diseases / Q000209:etiology / Q000235:genetics; D011110:Polymorphism, Genetic; D017594:Publication Bias; D017211:Treatment Failure
D015921:Dental Implants; D007375:Interleukin-1; D053582:Interleukin-1alpha; D053583:Interleukin-1beta