Chronic obstructive pulmonary disease and infection. Disruption of the microbiome?
The dynamics of infection in chronic obstructive pulmonary disease (COPD) are complex, and microbiome technology has provided us with a new research tool for its better understanding. There is compartmentalization of the microbiota in the various parts of the lung. Studies of the lower airway lumen microbiota in COPD have yielded confusing results, and additional studies with scrupulous attention to prevent and account for upper airway contamination of bronchoalveolar lavage samples are required. Lung tissue microbiota has been examined in three studies, which also demonstrate varied results based on the site of sampling (bronchial mucosa, lung parenchyma), and this variation extends to sampling sites within a lobe of the lung. The Vicious Circle Hypothesis embodies how an altered lung microbiome could contribute to COPD progression. Relating microbiota composition to airway and systemic inflammation and clinical outcomes are important research questions. Although various obstacles need to be surmounted, ultimately lung microbiome studies will provide new insights into how infection contributes to COPD.
1 Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University at Buffalo, State University of New York, Buffalo, New York; and Department of Veterans Affairs Western New York Healthcare System, Buffalo, New York.
Sanjay
S
Sethi
D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D018450:Disease Progression; D006801:Humans; D007249:Inflammation; D008168:Lung / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology; D064307:Microbiota; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology; D012141:Respiratory Tract Infections / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology