Green fabrication of quaternized chitosan/rectorite/Ag NP nanocomposites with antimicrobial activity.
Silver nanoparticles (Ag NPs) were synthesized rapidly in one pot via the Tollens reaction, in which quaternized chitosan (QCS) and rectorite (REC) acted as the reducing and stabilizing agent, while other chemical reducing and stabilizing agents and the surfactant were not included. X-ray diffraction, scanning electron microscopy and transmission electron microscopy results showed that spherical Ag NPs with uniform sizes were obtained, the layers of clay were peeled and thus exfoliated QCS/REC/Ag NP (QCRAg) nanocomposite was achieved. Moreover, Ag NPs dispersed well in the exfoliated nanocomposite matrix, some Ag NPs even entered into the interlayer of REC. QCRAg nanocomposites showed strong antimicrobial activity; the lowest minimum inhibitory concentration against Staphyloccocus aureus was only 0.0001% (w/v). The study reveals that the obtained QCRAg nanocomposites have great potential for biomedical applications.
Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006, People's Republic of China. State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China.
Jiwen
J
Luo
Meijia
M
Xie
Xiaoying
X
Wang
D000538:Aluminum Silicates / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D015195:Drug Design; D055772:Green Chemistry Technology; D053768:Metal Nanoparticles / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D008903:Minerals / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D050997:Nanomedicine / Q000379:methods; D012834:Silver / Q000737:chemistry*; D055672:Static Electricity; D013501:Surface-Active Agents
D000538:Aluminum Silicates; D000890:Anti-Infective Agents; D008903:Minerals; D013501:Surface-Active Agents; C546376:rectorite; D012834:Silver; D048271:Chitosan