Effects of chronic desipramine pretreatment on open field-induced suppression of blood natural killer cell activity and cytokine response depend on the rat's behavioral characteristics.
Effects of 14 consecutive day exposure to desipramine (10mg/kg i.p.), by itself or following chronic open field (OF) exposure, on subsequent neuroimmunological effects of acute (30 min) OF stress and the involvement of individual differences in response to novelty or social position in the anti-depressive responsiveness were investigated. Chronic desipramine pretreatment did not protect against OF stress-induced suppression of blood anti-tumor natural killer cell activity but increased plasma interleukin-10 and decreased interferon-γ and corticosterone concentration. These effects were particularly dangerous for the animals with increased responsivity to stress (desipramine alone) or with low behavioral activity (desipramine after chronic stress).
Department of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland. Electronic address: wronada3@o2.pl.
Danuta
D
Wrona
Department of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Magdalena
M
Listowska
Department of Experimental Neuroendocrinology, Institute of Pharmacology, PAS, Smętna 12, 31-343 Kraków, Poland.
Marta
M
Kubera
Department of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Wojciech
W
Glac
Department of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Beata
B
Grembecka
Department of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Karolina
K
Plucińska
Department of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Irena
I
Majkutewicz
Department of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Magdalena
M
Podlacha
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D016207:Cytokines / Q000096:biosynthesis / Q000097:blood; D003863:Depression / Q000097:blood / Q000276:immunology; D003891:Desipramine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D007694:Killer Cells, Natural / Q000187:drug effects*; D008297:Male; D015213:Neuroimmunomodulation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood / Q000276:immunology
D000929:Antidepressive Agents, Tricyclic; D016207:Cytokines; D003891:Desipramine
Desipramine; Natural killer cells; Open field; Plasma cytokines; Response to novelty; Social position