Relationship between common viral upper respiratory tract infections and febrile seizures in children from Suzhou, China.
This study aimed to determine the potential predisposing factors for the development of febrile seizures among children with upper respiratory tract infection in the eastern Chinese region. Participants were individuals aged 6 months and 6 years (n = 189) who were diagnosed with febrile seizure, complicated with upper respiratory tract infection, and 174 age-matched children who had upper respiratory tract infection without seizures as controls. The viral antigens including influenza A and B, parainfluenza, adenovirus, and respiratory syncytial virus were detected from nasopharyngeal aspirates. The incidence of influenza A infection was much higher in patients with febrile seizure than controls, especially those children aged >36 months. Patients with influenza A infection had higher body temperatures at seizure occurrence, shorter seizure duration, and shorter fever duration before seizure onset. Influenza A infections are frequently associated with febrile seizure in children with upper respiratory tract infection. During an influenza epidemic, effective vaccination of children, especially those with a past history of febrile seizure, may minimize the development of febrile seizure.
Department of Neurology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
Jihong
J
Tang
Department of Respiratory Medicine, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
Wenhua
W
Yan
Department of Neurology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China yan62bh@126.com.
Yan
Y
Li
Department of Neurology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
Bingbing
B
Zhang
Department of Neurology, Children's Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China.
Qing
Q
Gu
D000367:Age Factors; D001831:Body Temperature; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D009980:Influenza A virus; D008297:Male; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000453:epidemiology*; D003294:Seizures, Febrile / Q000453:epidemiology*
children; common respiratory viruses; febrile seizures; upper respiratory tract infections