Tryptophan hydroxylase 2 gene polymorphisms in Japanese patients with medication overuse headaches.
OBJECTIVE
We investigated whether tryptophan hydroxylase 2 (TPH2) gene polymorphisms were involved in the aggravation of migraines due to the overuse of medication.


METHODS
Forty-seven migraine patients (6 males and 41 females; 36.4 10.3 years) and 22 MOH patients (1 male and 21 females; 39.6 9.9 years) who had migraines participated in this study. The genotypes for the TPH2 gene polymorphisms (rs4565946, rs4570625, and rs4341581) were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methods.


RESULTS
The rs4565946, rs4570625, and rs4341581 genotypes were similarly distributed between migraine patients and MOH patients.


CONCLUSIONS
The results of this study showed no association between tryptophan TPH2 gene polymorphisms and the complication of MOH in patients with migraines.
Department of Pharmacology, Toxicology and Therapeutics, Division of Physiology and Pathology, Showa University School of Pharmacy, Tokyo 142-8555, Japan.
Masakazu
M
Ishii
Department of Neurology, Showa University School of Medicine, Tokyo 142-8666, Japan.
Hirotaka
H
Katoh
Department of Pharmacology, Toxicology and Therapeutics, Division of Physiology and Pathology, Showa University School of Pharmacy, Tokyo 142-8555, Japan.
Tomomi
T
Onaya
Department of Neurology, Showa University School of Medicine, Tokyo 142-8666, Japan.
Hideyo
H
Kasai
Department of Neurology, Showa University School of Medicine, Tokyo 142-8666, Japan.
Mitsuru
M
Kawamura
Department of Pharmacology, Toxicology and Therapeutics, Division of Physiology and Pathology, Showa University School of Pharmacy, Tokyo 142-8555, Japan.
Shunichi
S
Shimizu
D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051271:Headache Disorders, Secondary / Q000188:drug therapy / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014365:Tryptophan Hydroxylase / Q000235:genetics*
C494784:TPH2 protein, human; D014365:Tryptophan Hydroxylase