The impact of cell proliferation markers and p53 mutation status on prognosis of non-metastatic colon cancer.
OBJECTIVE
We aimed to evaluate the prognostic value of cell cycle proteins and p53 together with clinicopathologic features in non-metastatic resected colon cancer.


METHODS
One hundred nine patients who were diagnosed with resected colon cancer between 2006 and 2011 were analyzed retrospectively. Immunohistochemical staining analyses were used to evaluate the expression of cyclins D1 and A, p53 and Ki-67 in tumor tissue.


RESULTS
High cyclin D1 and cyclin A expression was more common in stage II than stage III tumors. Disease recurrence was more frequent in tumors with low cyclin D1 expression (P = 0.05). No significant association was observed between p53, Ki-67 or cyclin A expression and the risk of relapse and/or death. Multivariate analysis showed that the strongest predictor for a shorter disease-free survival period was extracapsular nodal invasion (ECNI).


CONCLUSIONS
We were not able to establish a strong association between patient prognosis and cyclins D1 and A, p53 or Ki-67 expression. However, a negative correlation between cyclin D1 and cyclin A expression and disease stage as well as more frequent relapses in patients with low expression of cyclin D1 suggested that cyclins may be predictive for early relapse in non-metastatic colon cancer.
Department of Medical Oncology, Ataturk Training and Resarch Hospital, Katip Celebi University, Izmir, Turkey; Department of Basic Oncology, Institute of Oncology, Dokuz Eylul University Medical Faculty, Izmir, Turkey.
Lutfiye
L
Demir
Nese
N
Ekinci
Cigdem
C
Erten
Isil
I
Somali
Alper
A
Can
Ahmet
A
Dirican
Suna
S
Cokmert
Vedat
V
Bayoglu
Murat
M
Akyol
Yuksel
Y
Kucukzeybek
Ahmet
A
Alacacioglu
Mustafa Oktay
MO
Tarhan
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002453:Cell Cycle; D049109:Cell Proliferation; D003110:Colonic Neoplasms / Q000737:chemistry / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D019925:Cyclin A / Q000032:analysis; D019938:Cyclin D1 / Q000032:analysis; D005260:Female; D016158:Genes, p53; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies
C530104:CCND1 protein, human; D019925:Cyclin A; D019394:Ki-67 Antigen; D019938:Cyclin D1
cell proliferation markers; colon cancer; p53 mutation; prognosis