The function of Fcγ receptors in dendritic cells and macrophages.
Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens and to receive feedback control from adaptive immune cells. Although it was long believed that all immunoglobulin Fc receptors are universally expressed by phagocytes, recent findings indicate that only monocyte-derived DCs and macrophages express high levels of activating Fc receptors for IgG (FcγRs), whereas conventional and plasmacytoid DCs express the inhibitory FcγR. In this Review, we discuss how the uptake, processing and presentation of antigens by DCs and macrophages is influenced by FcγR recognition of immunoglobulins and immune complexes in the steady state and during inflammation.
1] Laboratory of Immunoregulation, VIB Inflammation Research Center, 9052 Ghent, Belgium. [2] Department of Respiratory Medicine, Ghent University, 9000 Ghent, Belgium.
Martin
M
Guilliams
1] Institut Pasteur, Département d'Immunologie, Laboratoire Anticorps en Thérapie et Pathologie, 75015 Paris, France. [2] Institut National de la Santé et de la Recherche Médicale, U760, 75015 Paris, France.
Pierre
P
Bruhns
1] Laboratory of Immunoregulation, VIB Inflammation Research Center, 9052 Ghent, Belgium. [2] Department of Respiratory Medicine, Ghent University, 9000 Ghent, Belgium.
Yvan
Y
Saeys
1] Laboratory of Immunoregulation, VIB Inflammation Research Center, 9052 Ghent, Belgium. [2] Department of Respiratory Medicine, Ghent University, 9000 Ghent, Belgium.
Hamida
H
Hammad
1] Laboratory of Immunoregulation, VIB Inflammation Research Center, 9052 Ghent, Belgium. [2] Department of Respiratory Medicine, Ghent University, 9000 Ghent, Belgium. [3] Department of Pulmonary Medicine, Erasmus University Medical Center, 3015 Rotterdam, The Netherlands.
Bart N
BN
Lambrecht
D000818:Animals; D017951:Antigen Presentation; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology; D012333:RNA, Messenger / Q000032:analysis; D011961:Receptors, Fc / Q000276:immunology*; D017452:Receptors, IgG / Q000235:genetics / Q000502:physiology*
D012333:RNA, Messenger; D011961:Receptors, Fc; D017452:Receptors, IgG