Outcome and prognostic factors in bronchial carcinoids: a single-center experience.
BACKGROUND
The aim of this study is to assess factors influencing survival in patients with bronchial carcinoids (BCs).


METHODS
A retrospective review of our surgical database of patients operated for primary lung cancer with a final histologic diagnosis of BC in the period from January 1, 1995 to December 31, 2010 was carried out.


RESULTS
There were 126 patients (74 women): 83 had a typical carcinoid and 43 an atypical one (AC). All patients received a radical resection; systematic lymphadenectomy was accomplished in 120. Lymph nodal metastases were observed in 26 cases (12 N2) and were more frequent in ACs (p = 0.009). Twelve patients received adjuvant therapy (chemo/radio/biological). Distant metastases (DM) and local tumor recurrence occurred in 28 (22%) and 8 (6.3%) cases, respectively: DM were more frequent in ACs (p = 0.0001) and in N2 patients (p = 0.0001). Smoke, atypical histology, lymph nodal metastases, and high cellular proliferative index demonstrated to be statistically negative prognostic factors.


CONCLUSIONS
Even if characterized by an indolent behavior, BCs may spread to lymph node or distant or present with local recurrence. Amid all prognostic factors, the presence of DM demonstrated to be the strongest negative one.
Departments of *Thoracic Surgery, †Oncology and Biomedical Sciences, University of Torino, Torino, Italy.
Pier Luigi
PL
Filosso
Alberto
A
Oliaro
Enrico
E
Ruffini
Giulia
G
Bora
Paraskevas
P
Lyberis
Sofia
S
Asioli
Luisa
L
Delsedime
Alberto
A
Sandri
Francesco
F
Guerrera
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001984:Bronchial Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D002276:Carcinoid Tumor / Q000401:mortality / Q000556:secondary* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D009367:Neoplasm Staging; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult