The therapeutic target of estrogen receptor-alpha36 in estrogen-dependent tumors.
Estrogen receptor-alpha36 (ER-α36) is a new isoform of estrogen receptors without transcriptional activation domains of the classical ER-α(ER - α66). ER-α36 is mainly located in cytoplasm and plasma membrane. ER-α36 mediates non-genomic signaling and is involved in genomic signaling of other ERs. Recently ER-α36 is found to play a critical role in the development of estrogen-dependent cancers and endocrine resistance of breast cancer. The present article overviews and updates the biological nature and function of ER-α36, potential interaction of ER-α36 with other estrogen receptors and growth factor receptors, intracellular signaling pathways, potential mechanism by which ER-α36 may play an important role in the development of tumor resistance to endocrine therapies.
Yu
Y
Gu
Tianxiang
T
Chen
Elena
E
López
Weizhu
W
Wu
Department of Surgical Oncology, The 1st Affiliated Hospital, School of Medicine, Zhejiang University, 79, Qingchun Road, Hangzhou 310003 Zhejiang Province, China. xiangdong.wang@clintransmed.org.
Xiangdong
X
Wang
Jiang
J
Cao
Lisong
L
Teng
D047628:Estrogen Receptor alpha / Q000737:chemistry / Q000378:metabolism*; D004967:Estrogens / Q000378:metabolism*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D011494:Protein Kinases / Q000378:metabolism
D047628:Estrogen Receptor alpha; D004967:Estrogens; D036341:Intercellular Signaling Peptides and Proteins; D011494:Protein Kinases