Iron-catalyzed arylation of heterocycles via directed C-H bond activation.
The iron-catalyzed arylation of aromatic heterocycles, such as pyridines, thiophenes, and furans, has been achieved. The use of an imine directing group allowed for the ortho functionalization of these heterocycles with complete conversion in 15 min at 0 °C. Yields up to 88% were observed in the synthesis of 15 heterocyclic biaryls.
Department of Chemistry, University of Rhode Island , 51 Lower College Road, Kingston, Rhode Island 02881, United States.
John J
JJ
Sirois
Riley
R
Davis
Brenton
B
DeBoef
D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D006860:Hydrogen Bonding; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis*; D013876:Thiophenes / Q000138:chemical synthesis*
D005663:Furans; D006571:Heterocyclic Compounds; D011725:Pyridines; D013876:Thiophenes; D007501:Iron