Accurate prediction of nodal status in preoperative patients with pancreatic ductal adenocarcinoma using next-gen nanoparticle.
OBJECTIVE
The objective of this study is to assess lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) in identifying malignant nodal involvement in patients with pancreatic ductal adenocarcinoma.


METHODS
Magnetic resonance imaging was performed in 13 patients with known or high index of suspicion of pancreatic cancer and who were scheduled for surgical resection. Protocols included T2*-weighted imaging before and after administration of Ferumoxytol (Feraheme) for the evaluation of lymph node involvement. Eleven of the 13 patients underwent a Whipple procedure and lymph node dissection. Nodes that lacked contrast uptake were deemed malignant, and those that demonstrated homogeneous uptake were deemed benign.


RESULTS
A total of 264 lymph nodes were resection, of which 17 were malignant. The sensitivity and specificity of LNMRI was 76.5% and 98.4% at a nodal level and 83.3% and 80% at a patient level.


CONCLUSIONS
LNMRI demonstrated high sensitivity and specificity in patients with pancreatic ductal adenocarcinoma.
Department of Radiology, Massachusetts General Hospital, Boston, MA ; Center for Systems Biology, Massachusetts General Hospital, Boston, MA.
Shaunagh
S
McDermott
Department of Surgery, Massachusetts General Hospital, Boston, MA.
Sarah P
SP
Thayer
Department of Surgery, Massachusetts General Hospital, Boston, MA.
Carlos
C
Fernandez-Del Castillo
Department of Pathology, Massachusetts General Hospital, Boston, MA.
Mari
M
Mino-Kenudson
Department of Radiology, Massachusetts General Hospital, Boston, MA ; Center for Systems Biology, Massachusetts General Hospital, Boston, MA.
Ralph
R
Weissleder
Department of Radiology, Massachusetts General Hospital, Boston, MA ; Center for Systems Biology, Massachusetts General Hospital, Boston, MA.
Mukesh G
MG
Harisinghani