Impact of obesity and weight loss on cardiac performance and morphology in adults.
Obesity, particularly severe obesity is capable of producing hemodynamic alterations that predispose to changes in cardiac morphology and ventricular function. These include increased cardiac output, left ventricular hypertrophy and diastolic and systolic dysfunction of both ventricles. Facilitated by co-morbidities such as hypertension, the sleep apnea/obesity hypoventilation syndrome, and possibly certain neurohormonal and metabolic alterations, these abnormalities may predispose to left and right heart failure, a disorder known as obesity cardiomyopathy.
Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65202. Electronic address: alpertm@health.missouri.edu.
Martin A
MA
Alpert
Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65202.
Jad
J
Omran
Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65202.
Ankit
A
Mehra
Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65202.
Sivakumar
S
Ardhanari
D000328:Adult; D015992:Body Mass Index; D002302:Cardiac Output; D015897:Comorbidity; D018752:Diet, Fat-Restricted; D005260:Female; D006333:Heart Failure / Q000453:epidemiology* / Q000503:physiopathology; D054144:Heart Failure, Diastolic / Q000453:epidemiology / Q000503:physiopathology; D054143:Heart Failure, Systolic / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy* / Q000453:epidemiology* / Q000503:physiopathology; D010845:Obesity Hypoventilation Syndrome / Q000453:epidemiology / Q000503:physiopathology; D009767:Obesity, Morbid / Q000453:epidemiology / Q000503:physiopathology; D011379:Prognosis; D016019:Survival Analysis; D018487:Ventricular Dysfunction, Left / Q000453:epidemiology / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000453:epidemiology / Q000503:physiopathology; D015431:Weight Loss
BMI; BP; CAD; CBV; CO; Diastolic dysfunction; HF; HTN; High cardiac output; LA; LV; Left ventricular hypertrophy; Obesity; PVR; RAAS; RV; Systolic dysfunction; TG; blood pressure; body mass index; cardiac output; central blood volume; coronary artery disease; heart failure; left atrial or left atrium; left ventricular or left ventricle; peripheral vascular resistance; renin–angiotensin–aldosterone system; right ventricular or right ventricle; systemic hypertension; triglyceride(s)