Platelet count reduction and outcomes in living liver donors.
BACKGROUND
Platelet count reduction in living donors after graft harvesting is very common. The mechanisms and the subsequent adverse consequences are not clear. The present study was to explore the mechanisms and the consequences of platelet count reduction in living donors.


METHODS
We collected data from 231 living liver donor patients who donated at our transplant center between July 2002 and August 2009. Baseline and post-operative platelet counts were collected and analyzed. Multivariate logistic regression analysis was used to compare the risk factors for the persistent decrease in platelet counts. Complications and other post-operative recovery were compared between the donors.


RESULTS
Platelet count decreased differently at each of the follow-up intervals, and the average reduction from baseline evaluation to year 3 was 18.2%. A concomitant decrease in white blood cells was observed with platelet count reduction. All of the splenic volumes at the post-operative follow-up time points were significantly higher than those at baseline (P<0.01). Multivariate logistic regression analysis indicated that the graft-to-donor weight ratio was a risk factor for low post-operative platelet counts in living donors at the three follow-up time points: one week (P=0.047), one month (P=0.034), and three months (P=0.047). At the one week follow-up time, 77 donor platelet counts were higher (group 1) and 151 donor platelet counts were lower (group 2) than baseline levels. Two hemorrhage events (1.3%) were observed in group 2, while three hemorrhage events (3.9%) were observed in group 1 (P=0.211). The overall complication rate was comparable between the two groups (P=0.972).


CONCLUSIONS
An increase in harvesting graft may decrease platelet counts, but this reduction does not produce short- or long-term damage in living liver donors.
Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610041, China. ljydoctor@163.com.
Jian-Yong
JY
Lei
Wen-Tao
WT
Wang
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D008099:Liver / Q000601:surgery*; D016031:Liver Transplantation; D019520:Living Donors; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011184:Postoperative Period; D020127:Recovery of Function; D012189:Retrospective Studies; D012307:Risk Factors