[Gastroprotective and antisecretory effect of a phytochemical made from matico leaves (Piper aduncum)].
OBJECTIVE
To determine the gastroprotective and antisecretory effect of ethanol extract from matico leaves (Piper aduncum) in animal models.


METHODS
To evaluate the gastroprotective effect, 220 mice of the Balb C57 strain were used. They were randomized in 22 groups of ten animals each, in which the formation of gastric ulcers was induced with indomethacin. Gastroprotection was determined by evaluating three aspects: inflammation, number of hemorrhagic shocks and number of ulcers. To evaluate the antisecretory effect, 64 white male Holtzman rats were used, which were randomized in eight groups of eight animals, one control and seven groups of treatment with one extract dose level and two phytochemical dose levels. Antisecretion was obtained through the pylorus ligation.


RESULTS
Regarding gastroprotection, dichloromethane, chloroform, hexane and methanol extracts decreased inflammation to over 66% (p<0,05). The ethanolic extract shows 100% activity in reducing the number of hemorrhagic bands (p<0,05). The chloroform extract shows antiulcer activity at 75% (p<0,05). In terms of antisecretion, the phytochemical in capsules containing the ethanolic extract achieved 72% reduction of the gastric secretion volume (p<0,01) and 104,3% (p<0,01) PH increase.


CONCLUSIONS
In experimental conditions, ethanolic extracts, their fractions and phytochemicals have a gastroprotective effect in mice and antisecretory effect in rats.
Jorge
J
Arroyo
Pablo
P
Bonilla
Luis
L
Moreno-Exebio
Gerardo
G
Ronceros
Gloria
G
Tomás
Juana
J
Huamán
Ernesto
E
Raez
Mariano
M
Quino
Javier
J
Rodriguez-Calzado
D000818:Animals; D000431:Ethanol; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D031701:Piper; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D013272:Stomach Diseases / Q000517:prevention & control*
D010936:Plant Extracts; D000431:Ethanol