Fluoride levels and osteosarcoma.
BACKGROUND
Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma.


OBJECTIVE
The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water.


METHODS
The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls).


METHODS
Serum and drinking water fluoride levels were estimated by ion selective electrode.


METHODS
The data were computed as mean ± SD and Student's t test was applied.


RESULTS
Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P > 0.05, P > 0.001, respectively).


CONCLUSIONS
These results suggest a link between fluoride exposure and osteosarcoma.
Department of Biochemistry, Pt.BDS PGIMS, Rohtak, India.
Simmi
S
Kharb
Department of Biochemistry, Pt.BDS PGIMS, Rohtak, India.
Ravindra
R
Sandhu
Department of Orthopedics, Pt.BDS PGIMS, Rohtak, India.
Zile Singh
ZS
Kundu
Fluoride; osteosarcoma; serum; water