Microbial production of 1α-hydroxyvitamin D3 from vitamin D3.
The microbial transformation of vitamin D3 (1) by the fungi Candida maltosa R42 and Botrytis allii NRRL 2502 was investigated. Incubation of compound 1 with C. maltosa R42 and B. allii NRRL 2502 produced the same three more polar metabolites in small yields. The main metabolite was identified as 1α-hydroxyvitamin D3 (2). This biotransformation has utility as a possible tool for the production of 1α-hydroxyvitamin D3 from the readily available vitamin D3 for patients with compromised kidney function.
a Department of Pharmacognosy , Faculty of Pharmacy, Suez Canal University , Ismailia , Egypt.
Safwat A
SA
Ahmed
Mostafa K
MK
Mesbah
Diaa T
DT
Youssef
Sherief I
SI
Khalifa
D020171:Botrytis / Q000378:metabolism*; D002175:Candida / Q000378:metabolism*; D002762:Cholecalciferol / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006887:Hydroxycholecalciferols / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure
D006887:Hydroxycholecalciferols; D002762:Cholecalciferol; C008088:alfacalcidol