Concise syntheses of meridianins and meriolins using a catalytic domino amino-palladation reaction.
A synthesis of natural and synthetic members of the meridianin family of kinase inhibitory natural products has been developed. The sequence utilizes a variation of the Cacchi palladium-catalyzed domino reaction to efficiently construct the heterocyclic framework of the meridianins and meriolins from monocyclic precursors.
School of Chemistry and Physics, University of Adelaide , Adelaide, SA, Australia.
Scott R
SR
Walker
Milena L
ML
Czyz
Jonathan C
JC
Morris
D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D019086:Bridged Bicyclo Compounds, Heterocyclic; D006573:Heterocyclic Compounds, 1-Ring; D026121:Indole Alkaloids; D011743:Pyrimidines; C560347:meridianin A; C523800:meriolin 3; D010165:Palladium