Predominance of Gram-negative bacilli among patients with catheter-related bloodstream infections.
We evaluated changes in the epidemiology of catheter-related bloodstream infections (CRBSIs) between 1996 and 2012 in a tertiary care centre in Israel. The cohort included 1754 episodes of CRBSI. The incidence of CRBSIs decreased throughout the study period, whereas 30-day mortality following bacteraemia increased. There was a linear shift toward predominance of Gram-negative bacilli throughout the study period (p for trend<0.001). In 1996, 68% (68/100) of CRBSIs were caused by Gram-positive cocci, whereas in 2012 77.8% (28/26) were caused by Gram-negative bacilli. The shift towards Gram-negative CRBSIs and the associated mortality mandates that empirical treatment for CRBSIs be directed by local epidemiology.
Medicine H, Rambam Health Care Campus, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
E
E
Braun
K
K
Hussein
Y
Y
Geffen
G
G
Rabino
Y
Y
Bar-Lavie
M
M
Paul
D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology*; D055499:Catheter-Related Infections / Q000453:epidemiology* / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D007557:Israel; D012189:Retrospective Studies
Acinetobacter; Klebsiella; catheter-related bacteraemia; central venous catheter