Topical cream-based dosage forms of the macrocyclic drug delivery vehicle cucurbit[6]uril.
The macrocycle family of molecules called cucurbit[n]urils are potential drug delivery vehicles as they are able to form host-guest complexes with many different classes of drugs. This study aimed to examine the utility of Cucurbit[6]uril (CB[6]) in topical cream-based formulations for either localised treatment or for transdermal delivery. Cucurbit[6]uril was formulated into both buffered cream aqueous- and oily cream-based dosage forms. The solid state interaction of CB[6] with other excipients was studied by differential scanning calorimetry and the macrocycle's transdermal permeability was determined using rat skin. Significant solid state interactions were observed between CB[6] and the other dosage form excipients. At concentrations up to 32% w/w the buffered aqueous cream maintained its normal consistency and could be effectively applied to skin, but the oily cream was too stiff and is not suitable as a dosage form. Cucurbit[6]uril does not permeate through skin; as such, the results imply that cucurbituril-based topical creams may potentially only have applications for localised skin treatment and not for transdermal drug delivery.
Faculty of Pharmacy, The University of Sydney, Sydney, New South Whales, Australia.
Marian
M
Seif
Faculty of Pharmacy, The University of Sydney, Sydney, New South Whales, Australia.
Michael L
ML
Impelido
Faculty of Pharmacy, The University of Sydney, Sydney, New South Whales, Australia.
Michael G
MG
Apps
Faculty of Pharmacy, The University of Sydney, Sydney, New South Whales, Australia.
Nial J
NJ
Wheate
D000287:Administration, Topical; D001952:Bridged-Ring Compounds / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D004304:Dosage Forms; D016503:Drug Delivery Systems; D005453:Fluorescence; D007093:Imidazoles / Q000008:administration & dosage* / Q000737:chemistry; D014677:Pharmaceutical Vehicles; D012869:Skin Absorption; D013818:Thermogravimetry; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
D001952:Bridged-Ring Compounds; D004304:Dosage Forms; D007093:Imidazoles; D014677:Pharmaceutical Vehicles; C454805:cucurbit(6)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils