Renal cell carcinoma is more aggressive in Turkish patients with the metabolic syndrome.
BACKGROUND
Metabolic syndrome (MetS) is a multifactorial disease characterized by impaired glucose tolerance/diabetes, obesity, high triglyceride levels, low HDL levels, and hypertension. In this study we evaluate the relationship between tumor size and grade, and presence of the metabolic syndrome in patients with renal cell carcinoma.


METHODS
Between 2007-2013, radical nephrectomy was performed for 310 patients with renal tumors in our clinic and those with pathology reported renal cell carcinoma were enrolled and divided into two groups, with and without metabolic syndrome diagnosed on the basis of the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) criteria. The relationship between tumor size and grade of the two groups (Fuhrman nuclear degree) was evaluated statistically.


RESULTS
The metabolic syndrome was found in 70 patients, with a mean age of 65.5 (40-87), as compared to 58.8 (31-84) years in the non-metabolic syndrome group. Tumor size over 7 cm was found in 54% and 33%, respectively, and tumor grade over Fuhrman 3 in 56% and 32% of patients. Patients with metabolic syndrome had significantly higher tumor size and grade (p<0.05). In the presence of hypertension, diabetes and high triglyceride levels, significant assocations were again observed (p<0.05). Tumor size and degree also increased with increasing body mass index but this was not statistically significant (p>0.05).


CONCLUSIONS
Renal cancer is more aggressive in patients with metabolic syndrome. Lifestyle and risk factors were revealed to be significant influences in renal cancer patients.
Department of Urology, Okmeydani Training and Research Hospital, Istanbul, Turkey E-mail : mrt_drsn@hotmail.com.
Emin
E
Ozbek
Alper
A
Otunctemur
Suleyman
S
Sahin
Murat
M
Dursun
Huseyin
H
Besiroglu
Ismail
I
Koklu
Emre Can
EC
Polat
Mustafa
M
Erkoc
Eyyup
E
Danis
Muammer
M
Bozkurt
D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D002292:Carcinoma, Renal Cell / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D009392:Nephrectomy; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D014421:Turkey