Clinical arterial infusion of calcium gluconate: the preferred method for treating hydrofluoric acid burns of distal human limbs.
OBJECTIVE
This study was designed to evaluate the efficiency and safety of arterial infusions of calcium gluconate to treat hydrofluoric (HF) acid burns of the distal human limbs.


METHODS
Eligible patients with HF burn limbs, collected from January 2008 to October 2011, were given the arterial infusion of calcium gluconate into the injured limbs. The measures of pain were conducted before the infusion, immediately after the infusion, 4 h after the infusion, and 2 days after the infusion by the visual analogy score (VAS). If the VAS score was higher than 4.0 at the time point 4 h after the first infusion, the infusion was repeated. The time of wound healing, and the number and ratio of the cases receiving the surgical operation were also evaluated.


RESULTS
A total of 118 patients, male (107 cases) and female (11 cases), were collected, including 64 cases of outpatients and 54 cases of inpatients. The age of the subjects ranged from 16 to 60 years, with the mean age of 37.6. The burn sites were located in the lateral limbs (28 cases) and in the unilateral limbs (90 cases). For 107 cases, the pain scores decreased quickly after the first infusion. The other 11 cases, with the VAS score higher than 4.0 at the time point 4 h after the first infusion, received the second infusion. The average time of wound healing and the ratio of the cases receiving the surgical operation were closely related to the interval from the injury to the reception of infusion.


CONCLUSIONS
Arterial infusion of calcium gluconate, effectively relieving the pain, blocking wound progressive deepening, and causing no adverse effects, could be the preferential method to treat hydrofluoric acid burns of the distal human limbs.
Department of Burns, Zhejiang Quhua Hospital, Quzhou, China.
Zhang
Z
Yuanhai
Ni
N
Liangfang
Wang
W
Xingang
Jiang
J
Ruiming
Liu
L
Liping
Ye
Y
Chunjiang
Xia
X
Wenhao
Han
H
Chunmao
D000293:Adolescent; D000328:Adult; D002021:Buffers; D002057:Burns, Chemical / Q000188:drug therapy* / Q000209:etiology; D002125:Calcium Gluconate / Q000008:administration & dosage*; D005121:Extremities; D005260:Female; D006801:Humans; D006858:Hydrofluoric Acid / Q000633:toxicity*; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D060051:Occupational Injuries / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement; D014945:Wound Healing; D055815:Young Adult
D002021:Buffers; D006858:Hydrofluoric Acid; D002125:Calcium Gluconate