Systemic arterial endothelial function in children and young adults with idiopathic pulmonary arterial hypertension: is there a relation to pulmonary endothelium-dependent relaxation?
Pulmonary arterial endothelial function is known to be affected in patients with idiopathic pulmonary arterial hypertension (IPAH). Current reports also detected peripheral systemic arterial dysfunction in IPAH patients. The purpose of this study was to assess whether there is a relation between pulmonary arterial and systemic arterial endothelial function. Pulmonary arterial endothelium-dependent relaxation was assessed by changes in pulmonary blood flow in response to acetylcholine which were determined using intravascular Doppler flow measurements. Pulmonary flow reserve (PFR) was calculated as the ratio of pulmonary blood flow velocity in response to acetylcholine relative to baseline values. Systemic arterial endothelial function was assessed by the vascular response to reactive hyperemia, and was recorded non-invasively by peripheral arterial finger tonometry under standardized conditions. Thirteen children and young adults [mean age 16.7 (±5.6) years] with IPAH and 13 age-/gender-matched controls were included in the study. Digital reactive hyperemic index (RHI) of the IPAH patients was 1.54 (±0.69), and of the controls was 1.67 (±0.66) [p = 0.64]. The mean baseline flow velocity in the segmental pulmonary artery of all patients was 18.5 (±5.5) cm/s, increasing to 27.4 (±12.3) cm/s (p = 0.003) during acetylcholine infusion. The calculated mean PFR was 1.48 (±0.4). There was no significant correlation between the PFR and RHI (r = 0.19; p = 0.54). According to our results, systemic arterial endothelial function assessed by peripheral arterial finger tonometry was not significantly impaired in children and young adults with IPAH compared with age-/gender-matched controls. There was no correlation between systemic arterial and pulmonary arterial endothelial function, suggesting that different mechanisms may contribute to their pathogenesis and progression.
Pediatric Heart Centre, Justus-Liebig-University, Giessen, Germany, heiner.latus@googlemail.com.
Heiner
H
Latus
Anna
A
Werz
Ines
I
Kock
Stefan
S
Rupp
Gunter
G
Kerst
Joachim
J
Kreuder
Dietmar
D
Schranz
Christian
C
Apitz
D000109:Acetylcholine; D000293:Adolescent; D001783:Blood Flow Velocity; D002648:Child; D004730:Endothelium, Vascular / Q000503:physiopathology*; D065627:Familial Primary Pulmonary Hypertension / Q000503:physiopathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006940:Hyperemia; D008297:Male; D011651:Pulmonary Artery / Q000503:physiopathology*; D014665:Vasodilator Agents; D055815:Young Adult
D014665:Vasodilator Agents; D000109:Acetylcholine