Perinatal asphyxia in monochorionic versus dichorionic twins: incidence, risk factors and outcome.
OBJECTIVE
To estimate the incidence, risk factors, severity and outcome after perinatal asphyxia in monochorionic (MC) versus dichorionic (DC) twins.


METHODS
We included all consecutive near-term MC and DC twins with perinatal asphyxia admitted to our neonatal ward between 2004 and 2013 and compared the perinatal characteristics and neonatal outcome between both groups.


RESULTS
The incidence of perinatal asphyxia in MC and DC twin infants was 4.0 (11/272) and 4.0% (8/200; p = 1.00). In contrast to DC twins, asphyxia in MC twins was strongly associated with acute exsanguination and anemia at birth; 64% (7/11) in MC twins and 0% (0/8) in DC twins (p < 0.01). Median hemoglobin level at birth in the MC and DC groups was 11.5 and 18.6 g/dl, respectively (p < 0.01).


CONCLUSIONS
Perinatal asphyxia in MC twins is often associated with severe anemia at birth due to acute hemorrhage through the placental vascular anastomoses.
Division of Neonatology, Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands.
A
A
van Steenis
H E
HE
Kromhout
S J
SJ
Steggerda
M
M
Sueters
M
M
Rijken
D
D
Oepkes
E
E
Lopriore
D001237:Asphyxia / Q000453:epidemiology* / Q000209:etiology; D004200:Diseases in Twins / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005311:Fetal Hypoxia / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D012189:Retrospective Studies; D012307:Risk Factors