Methicillin-susceptible Staphylococcus aureus clonal complex 398: high prevalence and geographical heterogeneity in bone and joint infection and nasal carriage.
The prevalence of clonal complex (CC) 398 methicillin-susceptible Staphylococcus aureus (MSSA) was unexpectedly high among bone and joint infections (BJIs) and nasal-colonizing isolates in France, with surprising geographical heterogeneity. With none of the major, most-known staphylococcal virulence genes, MSSA CC398 BJI was associated with lower biological inflammatory syndrome and lower treatment failure rates.
Bacteriology Department, Groupement Hospitalier Nord, Hospices Civils de Lyon, Lyon, France; Infectious Diseases Department, Hospices Civils de Lyon, Lyon, France; International Centre for Research in Infectious Diseases, INSERM U1111, Université Claude Bernard Lyon 1, Lyon, France.
F
F
Valour
J
J
Tasse
S
S
Trouillet-Assant
J-P
JP
Rasigade
B
B
Lamy
E
E
Chanard
P
P
Verhoeven
J-W
JW
Decousser
H
H
Marchandin
M
M
Bès
C
C
Chidiac
F
F
Vandenesch
T
T
Ferry
F
F
Laurent
D000328:Adult; D000368:Aged; D001170:Arthritis, Infectious / Q000453:epidemiology / Q000382:microbiology*; D001850:Bone Diseases, Infectious / Q000453:epidemiology / Q000382:microbiology*; D002353:Carrier State / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D008875:Middle Aged; D009666:Nose / Q000382:microbiology*; D015995:Prevalence; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000145:classification* / Q000302:isolation & purification*
Clonal complex 398; bone and joint infection; methicillin-susceptible Staphylococcus aureus; molecular epidemiology; nasal carriage; virulence factors