Concise review: parthenote stem cells for regenerative medicine: genetic, epigenetic, and developmental features.
Embryonic stem cells (ESCs) have the potential to provide unlimited cells and tissues for regenerative medicine. ESCs derived from fertilized embryos, however, will most likely be rejected by a patient's immune system unless appropriately immunomatched. Pluripotent stem cells (PSCs) genetically identical to a patient can now be established by reprogramming of somatic cells. However, practical applications of PSCs for personalized therapies are projected to be unfeasible because of the enormous cost and time required to produce clinical-grade cells for each patient. ESCs derived from parthenogenetic embryos (pESCs) that are homozygous for human leukocyte antigens may serve as an attractive alternative for immunomatched therapies for a large population of patients. In this study, we describe the biology and genetic nature of mammalian parthenogenesis and review potential advantages and limitations of pESCs for cell-based therapies.
Departments of Cell and Developmental Biology and Molecular and Medical Genetics, and Program in Molecular and Cellular Biosciences, School of Medicine, and Divisions of Reproductive and Developmental Sciences, Oregon National Primate Research Center, and Reproductive Endocrinology, Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA.
Brittany
B
Daughtry
Shoukhrat
S
Mitalipov
D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D053595:Embryonic Stem Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism* / Q000637:transplantation; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D010312:Parthenogenesis / Q000235:genetics*; D011003:Ploidies; D044968:Regenerative Medicine
D006680:HLA Antigens
Histocompatibility; Imprinting; Parthenogenesis; Pluripotent stem cells