Lens capsule as a model to study type IV collagen.
The study of collagen IV has benefited greatly from the seminal work conducted by Arthur Veis and colleagues over three decades ago. Through a series of electron microscopy studies focused on lens basement membrane, an appreciation was gained for the distinct network-forming properties of collagen IV. Veis correctly suggested that network assembly is a phenomenon of the non-collagenous termini of the molecule. This review seeks to document how the field advanced following these seminal conclusions, including recent discoveries regarding the molecular reinforcement of networks that support Veis' conclusions.
Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center , Nashville, TN , USA .
Christopher F
CF
Cummings
Billy G
BG
Hudson
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D002477:Cells / Q000378:metabolism; D024141:Collagen Type IV / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000378:metabolism*; D008954:Models, Biological
D024141:Collagen Type IV