Increased risk of solid renal tumors in lithium-treated patients.
Cystic kidney diseases and toxic interstitial nephritis may be complicated by renal tumors. Long-term lithium intake is associated with tubulointerstitial nephritis and renal cysts but to date such an association with tumors has not been determined. We evaluated this in a retrospective study to determine whether lithium-treated patients were at higher risk of renal tumors compared with lithium-free patients with chronic kidney disease (CKD), and to the general population. Over a 16-year period, 14 of 170 lithium-treated patients had renal tumors, including seven malignant and seven benign tumors. The mean duration of lithium exposure at diagnosis was 21.4 years. The renal cancers included three clear-cell and two papillary renal cell carcinomas, one hybrid tumor with chromophobe and oncocytoma characteristics, and one clear-cell carcinoma with leiomyomatous stroma. The benign tumors included four oncocytomas, one mixed epithelial and stromal tumor, and two angiomyolipomas. The percentage of renal tumors, particularly cancers and oncocytomas, was significantly higher in lithium-treated patients compared with 340 gender-, age-, and estimated glomerular filtration rate (eGFR)-matched lithium-free patients. Additionally, the Standardized Incidence Ratio of renal cancer was significantly higher in lithium-treated patients compared with the general population: 7.51 (95% confidence interval (CI) (1.51-21.95)) and 13.69 (95% CI (3.68-35.06)) in men and women, respectively. Thus, there is an increased risk of renal tumors in lithium-treated patients.
1] Department of Nephrology-Transplantation, Necker Hospital, APHP, Paris Descartes University, Paris, France [2] Paris Descartes University, Sorbonne Paris Cité, Paris, France [3] INSERM U845, Centre de Recherche "Croissance et Signalisation", Paris, France.
Mohamad
M
Zaidan
Department of Nephrology, Tenon Hospital, APHP, Paris, France.
Fabien
F
Stucker
1] INSERM U1018, Centre for Epidemiology and Population Health, Villejuif, France [2] UMRS 1018, Univ Paris-Sud, Villejuif, France.
Bénédicte
B
Stengel
Department of Pathology, Necker Hospital, APHP, Paris Descartes University, Paris, France.
Viorel
V
Vasiliu
1] Department of Nephrology-Transplantation, Necker Hospital, APHP, Paris Descartes University, Paris, France [2] Paris Descartes University, Sorbonne Paris Cité, Paris, France.
Aurélie
A
Hummel
1] Paris Descartes University, Sorbonne Paris Cité, Paris, France [2] Department of Biostatistics, Necker Hospital, Paris, France.
Paul
P
Landais
1] Department of Nephrology, Tenon Hospital, APHP, Paris, France [2] UPMC Univ Paris 6, Paris, France.
Jean-Jacques
JJ
Boffa
1] Department of Nephrology, Tenon Hospital, APHP, Paris, France [2] UPMC Univ Paris 6, Paris, France.
Pierre
P
Ronco
1] Department of Nephrology-Transplantation, Necker Hospital, APHP, Paris Descartes University, Paris, France [2] Paris Descartes University, Sorbonne Paris Cité, Paris, France.
Jean-Pierre
JP
Grünfeld
1] Department of Nephrology-Transplantation, Necker Hospital, APHP, Paris Descartes University, Paris, France [2] Paris Descartes University, Sorbonne Paris Cité, Paris, France.
Aude
A
Servais
D018249:Adenoma, Oxyphilic / Q000209:etiology / Q000473:pathology; D000328:Adult; D018207:Angiomyolipoma / Q000209:etiology / Q000473:pathology; D018692:Antimanic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001714:Bipolar Disorder / Q000150:complications / Q000188:drug therapy; D002292:Carcinoma, Renal Cell / Q000209:etiology / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D018020:Lithium Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D051436:Renal Insufficiency, Chronic / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
D018692:Antimanic Agents; D018020:Lithium Compounds