Intensity and sulci landmark combined brain atlas construction for Chinese pediatric population.
Constructing an atlas from a population of brain images is of vital importance to medical image analysis. Especially in neuroscience study, creating a brain atlas is useful for intra- and inter-population comparison. Research on brain atlas construction has attracted great attention in recent years, but the research on pediatric population is still limited, mainly due to the limited availability and the relatively low quality of pediatric magnetic resonance brain images. This article is targeted at creating a high quality representative brain atlas for Chinese pediatric population. To achieve this goal, we have designed a set of preprocessing procedures to improve the image quality and developed an intensity and sulci landmark combined groupwise registration method to align the population of images for atlas construction. As demonstrated in experiments, the newly constructed atlas can better represent the size and shape of brains of Chinese pediatric population, and show better performance in Chinese pediatric brain image analysis compared with other standard atlases.
Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR; Research Center for Medical Image Computing, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR.
Yishan
Y
Luo
Lin
L
Shi
Jian
J
Weng
Hongjian
H
He
Winnie C W
WC
Chu
Feiyan
F
Chen
Defeng
D
Wang
D044466:Asian People; D001271:Atlases as Topic; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development; D002648:Child; D002681:China; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size
atlas construction; image registration; magnetic resonance image; pediatric population