X-inactivation: Xist RNA uses chromosome contacts to coat the X.
The mechanisms by which Xist RNA associates with the X chromosome to mediate alterations in chromatin structure remain mysterious. Recent genome-wide Xist RNA distribution studies suggest that this long noncoding RNA uses 3-dimensional chromosome contacts to move to its sites of action.
Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA; Department of Anatomy, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA.
Karen N
KN
Leung
Department of Biochemistry and Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA. Electronic address: Barbara.Panning@ucsf.edu.
Barbara
B
Panning
D000818:Animals; D005260:Female; D016678:Genome; D008297:Male; D062085:RNA, Long Noncoding / Q000378:metabolism*; D014960:X Chromosome / Q000378:metabolism*; D049951:X Chromosome Inactivation
D062085:RNA, Long Noncoding