Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
Herpesviruses encode membrane-associated G protein-coupled receptors (GPCRs) in their viral genomes that are structurally similar to chemokine receptors. These GPCRs hijack GPCR-mediated cellular signalling networks of the host for survival, replication and pathogenesis. In particular the herpesvirus-encoded chemokine receptors ORF74, BILF1 and US28, which are present at inflammatory sites and tumour cells, provide important virus-specific targets for directed therapies. Given the high druggability of GPCRs in general, these viral GPCRs can be considered promising antiviral drug targets.
Amsterdam Institute for Molecules Medicines and Systems, Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
Henry F
HF
Vischer
Amsterdam Institute for Molecules Medicines and Systems, Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
Marco
M
Siderius
Amsterdam Institute for Molecules Medicines and Systems, Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
Rob
R
Leurs
Amsterdam Institute for Molecules Medicines and Systems, Division of Medicinal Chemistry, Faculty of Sciences, VU University, Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
Martine J
MJ
Smit
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D049109:Cell Proliferation / Q000187:drug effects; D006564:Herpesviridae / Q000235:genetics / Q000472:pathogenicity*; D006566:Herpesviridae Infections / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D006801:Humans; D011485:Protein Binding; D019707:Receptors, Chemokine / Q000235:genetics* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014412:Tumor Virus Infections / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000998:Antiviral Agents; D019707:Receptors, Chemokine; D043562:Receptors, G-Protein-Coupled; D014764:Viral Proteins