Performance of β-tricalcium phosphate granules and putty, bone grafting materials after bilateral sinus floor augmentation in humans.
Sinus floor augmentation (SFA) using bone grafting materials, and in particular calcium phosphates (CaP), is a well-established pre-implantology procedure. The use of CaP simplifies SFA procedures. β-tricalcium phosphate (β-TCP) is amply used for SFA. This study evaluated the clinical and osteogenic performance of β-TCP granules (TCP-G) and a β-TCP putty (TCP-P) bone graft material. TCP-P consisted of TCP-G in a hyaluronic acid (HyA) carrier. Bone formation, volume stability and osteogenic marker expression after bilateral SFA in patients was assessed. Eight patients were selected for a split-mouth design. Biopsies obtained six months after SFA, were processed for immunohistochemical analysis of collagen type I (Col I), alkaline phosphatase (ALP), osteocalcin (OC) and bone sialoprotein (BSP). Histomorphometric analysis determined bone, grafting material and marrow space percentages. Cone-beam computed tomography was used to calculate the graft volume and its stability. Both materials allowed excellent bone regeneration and volume stability. TCP-P displayed better surgical handling properties, greater bone formation, higher expression of Col I, ALP, OC and BSP; as well as significantly lower grafting volume reduction values. HyA had no adverse effect on TCP-P performance. Due to its clinical and osteogenic performance, TCP-P can be regarded as excellent bone grafting material for SFA.
Dept. of Oral Surgery, Charité University Medical Center Berlin, 14197 Berlin, Germany.
Michael
M
Stiller
Dept. of Experimental Dentistry, Charité University Medical Center Berlin, 14197 Berlin, Germany.
Esther
E
Kluk
RMS Foundation, 2544 Bettlach, Switzerland.
Marc
M
Bohner
Dept. of Experimental Orofacial Medicine, Philipps University, 35039 Marburg, Germany.
Marco A
MA
Lopez-Heredia
Department of Traumatology and Orthopaedics, Hospital for Special Surgery, 44534 Lünen, Germany.
Christian
C
Müller-Mai
Dept. of Experimental Orofacial Medicine, Philipps University, 35039 Marburg, Germany. Electronic address: knabec@med.uni-marburg.de.
Christine
C
Knabe
D001672:Biocompatible Materials; D016025:Bone Transplantation; D002130:Calcium Phosphates / Q000737:chemistry*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry; D008297:Male; D059546:Sinus Floor Augmentation / Q000379:methods*
D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D006820:Hyaluronic Acid
Granules; Putty; Sinus floor augmentation; Split-mouth design; β-TCP bone graft