Significance of higher-order chromatin architecture for neuronal function and dysfunction.
Recent studies in neurons indicate that the large-scale chromatin architectural framework, including chromosome territories or lamina-associated chromatin, undergoes dynamic changes that represent an emergent level of regulation of neuronal gene-expression. This phenomenon has been implicated in neuronal differentiation, long-term potentiation, seizures, and disorders of neural plasticity such as Rett syndrome and epilepsy.
Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteura 3, 02-093 Warsaw, Poland. Electronic address: g.wilczynski@nencki.gov.pl.
Grzegorz M
GM
Wilczynski
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D042002:Chromatin Assembly and Disassembly; D044127:Epigenesis, Genetic; D004827:Epilepsy / Q000378:metabolism / Q000473:pathology; D005786:Gene Expression Regulation; D006801:Humans; D017774:Long-Term Potentiation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism* / Q000473:pathology; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology / Q000378:metabolism* / Q000473:pathology; D034881:Nuclear Lamina / Q000378:metabolism / Q000473:pathology; D015518:Rett Syndrome / Q000378:metabolism / Q000473:pathology
D009419:Nerve Tissue Proteins
Cell nucleus; Chromatin; Chromosome territory