Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells.
Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of DRG2 in EAE was mediated by the inhibition of the development of T(H)17 cells. DRG2 enhanced the activity of PPARγ, which led to an inhibition of the nuclear factor kappa B (NF-κB) activity and IL-6 production in antigen presenting cells and an inhibition of the development of T(H)17 cells. Our results demonstrate that DRG2 is an essential modulator of EAE.
Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea; Department of Medical Science, University of Ulsan College of Medicine, Seoul 138-736, South Korea.
Myoung Seok
MS
Ko
Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
Hyo Jeong
HJ
Kim
Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
Hong Kyung
HK
Kim
Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
Nal Ae
NA
Yoon
Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
Unn Hwa
UH
Lee
Personalized Medicine System R&D Center, Bio-Support Co., Ltd., Anyang, Kyeonggi-Do 431-810, South Korea.
Sang Chul
SC
Lee
School of Biotechnology and Institute of Life Science and Resources, Kyung Hee University, Yongin 449-701, South Korea.
Dae Kyun
DK
Chung
Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea.
Byung Ju
BJ
Lee
Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, South Korea.
Jae Hee
JH
Suh
Biomedical Research Center, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan 682-060, South Korea.
Wha Ja
WJ
Cho
Department of Biological Sciences, University of Ulsan, Ulsan 680-749, South Korea. Electronic address: jwpark@ulsan.ac.kr.
Jeong Woo
JW
Park
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D002454:Cell Differentiation; D056970:Co-Repressor Proteins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D005838:Genotype; D018836:Inflammation Mediators / Q000378:metabolism; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D016328:NF-kappa B / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D058504:Th17 Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
D056970:Co-Repressor Proteins; D016207:Cytokines; D018836:Inflammation Mediators; D015850:Interleukin-6; D016328:NF-kappa B; D047495:PPAR gamma; C078418:developmentally regulated GTP-binding protein; D019204:GTP-Binding Proteins
DRG2; EAE; IL-6; NF-κB; PPARγ; T(H)17