Psychometric properties of Chinese language Liverpool Seizure Severity Scale 2.0 (LSSS 2.0) and status and determinants of seizure severity for patients with epilepsy in China.
OBJECTIVE
This study aimed to translate and validate the Liverpool Seizure Severity Scale (LSSS) in Chinese-speaking patients with epilepsy and explore the determinants of seizure severity in China.


METHODS
Accepted procedures were followed to translate the LSSS. Each participant was interviewed to complete the LSSS, Seizure Severity Index, Quality of Well-being Scale Self-Administered (QWB-SA), EuroQol (EQ-5D), and Mini Mental State Examination (MMSE). Construct validity and internal consistency were assessed. The determinants of seizure severity were explored.


RESULTS
The construct validity of the LSSS was demonstrated by good convergent and discriminant validities. Cronbach's alpha and the intraclass correlation coefficient were 0.886, respectively. In the multivariate analysis, seizure types (p=0.001), seizure frequency (p=0.001), and numbers of antiepileptic drugs (p=0.042) predicted the scores on the LSSS. Types of antiepileptic drugs also contributed to the variation in the LSSS scores.


CONCLUSIONS
Chinese LSSS is a valid, reliable, and sensitive seizure severity scale. Seizure frequency, seizure types, and quantities and types of AEDs predict seizure severity.
School of Biomedical Sciences & Pharmacy, The University of Newcastle, Callaghan, NSW, Australia.
Lan
L
Gao
Neurology Department, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Li
L
Xia
Neurology Department, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Song-Qing
SQ
Pan
Neurology Department, The Fifth Hospital of Wuhan, Wuhan, Hubei, China.
Tao
T
Xiong
School of Biomedical Sciences & Pharmacy, The University of Newcastle, Callaghan, NSW, Australia. Electronic address: ShuChuen.Li@newcastle.edu.au.
Shu-Chuen
SC
Li
D000328:Adult; D000704:Analysis of Variance; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D011594:Psychometrics / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014175:Translating; D055815:Young Adult
Epilepsy; EuroQol (EQ-5D); Health-related quality of life; Liverpool Seizure Severity Scale; Quality of Well-being Scale Self-administered (QWB-SA); Seizure severity