Osseous metaplasia within a canine insulinoma.
An 11-year-old male castrated mixed-breed dog was presented for exercise intolerance, tetraparesis, and persistent hypoglycemia. Abdominal ultrasound examination revealed 2 nodules within the right limb of the pancreas. Cytology from one nodule was consistent with a carcinoma of neuroendocrine origin, with a primary differential diagnosis of insulinoma. Histologic evaluation and immunohistochemistry for synaptophysin and insulin confirmed the diagnosis of insulinoma. Additionally, there was a solitary nodule of mineralized compact bone composing approximately 60% of the mass. To the authors' knowledge, this is the first report of osseous metaplasia within an insulinoma (islet cell carcinoma).
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Emily M
EM
Pieczarka
Duncan S
DS
Russell
Kelly S
KS
Santangelo
Famke
F
Aeffner
Mary Jo
MJ
Burkhard
D000818:Animals; D044963:Biopsy, Fine-Needle / Q000662:veterinary; D001842:Bone and Bones / Q000473:pathology; D018273:Carcinoma, Islet Cell / Q000473:pathology / Q000662:veterinary*; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D037901:Euthanasia, Animal; D007003:Hypoglycemia / Q000473:pathology / Q000662:veterinary*; D007328:Insulin / Q000378:metabolism; D007340:Insulinoma / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008679:Metaplasia; D009820:Ohio; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000662:veterinary*; D016708:Synaptophysin / Q000378:metabolism
D007328:Insulin; D016708:Synaptophysin
Bone; dog; islet cell carcinoma; pancreas