Development of an experimental model of infected bone void in the ulna of rabbits.
OBJECTIVE
Develop a model that allowed the study of bone regeneration in infection conditions.


METHODS
A 15 mm defect was surgically created in the rabbit ulna and inoculated with 5x10(8) colony-forming units (CFU) of S. aureus. Surgical debridement was performed two weeks after and systemic gentamicin was administered for four weeks. Animals were followed up to 12 weeks to evaluate infection control and bone regeneration.


RESULTS
Bone regeneration was inferior to 25% of the defect in radiological and histological analysis.


CONCLUSIONS
Infected bone defect of 15 mm in the rabbit ulna was unable to achieve full regeneration without further treatment. Level of Evidence V, Experimental Study.
Department of Biomechanics, Medicine and Rehabilitation of the Musculoskeletal System, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo.
Matheus
M
Lemos Azi
Department of Biomechanics, Medicine and Rehabilitation of the Musculoskeletal System, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo.
Mauricio
M
Kfuri Junior
Department of Clinical Medicine, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo.
Roberto
R
Martinez
Department of Surgery, Oral and Maxillofacial Traumatology and Periodontics, Faculdade de Odontologia de Ribeirão Preto da Universidade de São Paulo.
Luis Antonio
LA
Salata
Department of Biomechanics, Medicine and Rehabilitation of the Musculoskeletal System, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo.
Cleber Antonio Jansen
CA
Paccola
Bone diseases; Bone regeneration; Infectious; Rabbits