Brain natriuretic peptide upon admission as a biological marker of short-term mortality after intracerebral hemorrhage.
OBJECTIVE
The purpose of the present study was to test the hypothesis that plasma brain natriuretic peptide (BNP) is associated with short-term mortality after intracerebral hemorrhage (ICH).


METHODS
We prospectively enrolled 271 patients (median age 72 years; 109 females) who were admitted within 24 h of ICH onset between April 2007 and July 2011 and in whom plasma BNP levels were measured upon admission. The patients were assigned to two groups according to survival within 1 month of ICH. Factors associated with mortality were determined by multivariate logistic regression analysis.


RESULTS
Within 1 month of ICH, 48 (17.7%) of the 271 enrolled patients died. The median (interquartile range) level of plasma BNP was significantly higher in the group of non-survivors than in the group of survivors [102.5 (48.7-205.0) vs. 32.4 (17.3-85.0) pg/ml; p < 0.001]. A cutoff BNP level of 60.0 pg/ml could predict death within 1 month of ICH. Multivariate logistic regression analysis showed that a plasma BNP of >60.0 pg/ml (OR 4.7; 95% CI 1.43-15.63; p = 0.011) was independently associated with mortality within 1 month after ICH.


CONCLUSIONS
A high BNP level upon admission is associated with mortality within 1 month after ICH.
Department of Stroke Medicine, Kawasaki Medical School, Kurashiki, Japan.
Yoshino
Y
Goya
Kensaku
K
Shibazaki
Kenichiro
K
Sakai
Junya
J
Aoki
Jyunichi
J
Uemura
Naoki
N
Saji
Katsunori
K
Isa
Yusuke
Y
Ohya
Kazumi
K
Kimura
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000401:mortality*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011379:Prognosis
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain