Copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters: one-pot synthesis of 2-arylpyridines.
The first example of the copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters has been developed, leading to a wide range of 2-arylpyridines in a one-pot synthesis with moderate to good yields without an additional reductant. This transformation allows for rapid access to a variety of 2-arylpyridines using an inexpensive catalytic system that would be more difficult to access with traditional methods. Thus, this method represents a simple and practical procedure to access 2-arylpyridines.
College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China. jiuxichen@wzu.edu.cn huayuewu@wzu.edu.cn.
Yan
Y
Shen
Jiuxi
J
Chen
Miaochang
M
Liu
Jinchang
J
Ding
Wenxia
W
Gao
Xiaobo
X
Huang
Huayue
H
Wu