Positive sentinel lymph node metastasis from a metastasis in Melanoma.
The rationale for certain patterns of metastatic spread seen in melanoma is not well understood. Currently, there is no clear experimental evidence to support the potential for metastases to form metastases in this disease. We report a case of a 31-year-old woman, with metastatic melanoma, who developed axillary lymph node metastases hypothesized to originate from a breast metastasis rather than the primary disease. Improved understanding of the underlying molecular processes involved in systemic spread would facilitate development of improved adjuvant therapies and prognostic markers.
Department of Medical Oncology, Cancer Centre, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Samantha
S
Bowyer
Kynan
K
Feeney
Michael
M
Millward
D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis / Q000556:secondary*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008545:Melanoma / Q000473:pathology*; D049268:Positron-Emission Tomography; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000473:pathology*