TPO signal for stem cell genomic integrity.
In this issue of Blood, de Laval et al report on a novel mechanism by which hematopoietic stem cells (HSCs) harboring DNA damage are rescued by thrombopoietin (TPO)-mediated DNA repair.1 It has been recently demonstrated that HSCs use the error-prone nonhomologous end-joining (NHEJ) pathway of DNA repair to fix DNA breaks. Maintenance of genomic integrity is crucial for HSC function. Finding the players involved in HSC DNA repair will provide a better understanding of hematopoietic homeostasis, HSC aging, and leukemogenesis.
KANAZAWA UNIVERSITY.
Atsushi
A
Hirao
D000818:Animals; D004260:DNA Repair; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D017874:Immediate-Early Proteins / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D013926:Thrombopoietin / Q000378:metabolism*
C518820:IEX-1 protein, mouse; D017874:Immediate-Early Proteins; D016328:NF-kappa B; D013926:Thrombopoietin; D048049:Extracellular Signal-Regulated MAP Kinases