Infective endocarditis and meningitis due to Scedosporium prolificans in a renal transplant recipient.
Scedosporium prolificans is a ubiquitous filamentous fungi that may cause disseminated diseases in neutropenic patients with hematological malignancies. We report a fatal case of renal transplant recipient who developed both infective endocarditis and meningitis due to S. prolificans during treatment with micafungin and itraconazole for chronic necrotizing aspergillosis. Breakthrough Scedosporium infection should be considered among differential diagnosis of invasive fungal diseases in patients with renal transplant recipients receiving antifungal agents.
Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, Japan. Electronic address: hello_kenji2004@yahoo.co.jp.
Kenji
K
Uno
Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, Japan.
Kei
K
Kasahara
Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, Japan.
Satoshi
S
Kutsuna
Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, Japan.
Yuichi
Y
Katanami
Second Department of Internal Medicine, Nara Medical University, Nara, Japan.
Yoshifumi
Y
Yamamoto
Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, Japan.
Koichi
K
Maeda
Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, Japan.
Mitsuru
M
Konishi
Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, Japan.
Taku
T
Ogawa
Department of Urology, Nara Medical University, Nara, Japan.
Tatsuo
T
Yoneda
Department of Urology, Nara Medical University, Nara, Japan.
Katsunori
K
Yoshida
Second Department of Internal Medicine, Nara Medical University, Nara, Japan.
Hiroshi
H
Kimura
Center for Infectious Diseases, Nara Medical University, 840 Shijo-cho, Kashihara City, Nara, Japan.
Keiichi
K
Mikasa
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy; D004696:Endocarditis / Q000382:microbiology*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D016921:Meningitis, Fungal / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology*; D021681:Scedosporium / Q000302:isolation & purification*
D000935:Antifungal Agents
Disseminated infection; Infective endocarditis; Kidney transplantation; Meningitis; Scedosporium prolificans