Catalytic reductive dehydration of tertiary amides to enamines under hydrosilylation conditions.
Tertiary amides are efficiently reduced to their corresponding enamines under hydrosilylation conditions, using a transition-metal-free catalytic protocol based on t-BuOK (5 mol %) and (MeO)3SiH or (EtO)3SiH as the reducing agent. The enamines were formed with high selectivity in good-to-excellent yields.
Department of Organic Chemistry, Stockholm University , The Arrhenius Laboratory, SE-106 91 Stockholm, Sweden.
Alexey
A
Volkov
Fredrik
F
Tinnis
Hans
H
Adolfsson