Palladium-catalyzed aza-Wittig-type condensation of isoxazol-5(4H)-ones with aldehydes.
This paper describes the development of a palladium-catalyzed decarboxylative inter- and intramolecular condensation reaction of isoxazol-5(4 H)-ones with carbonyl compounds in the presence of PPh3 , giving various 2-azabuta-1,3-dienes or pyrroles in moderate to high yields.
Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510 (Japan). kokamoto@scl.kyoto-u.ac.jp.
Kazuhiro
K
Okamoto
Takuya
T
Shimbayashi
Eisuke
E
Tamura
Kouichi
K
Ohe
Staudinger reaction; aza-wittig; decarboxylation; nitrene transfer; palladium