Pathologic and clinical characteristics of elderly patients with breast cancer: a retrospective analysis of a multicenter study (Anatolian Society of Medical Oncology).
There is very little information about breast cancer characteristics, treatment choices, and survival among elderly patients. The purpose of this multicenter retrospective study was to examine the clinical, pathologic, and biologic characteristics of 620 breast cancer patients age 70 years or older. Between June 1991 and May 2012, 620 patients with breast cancer, recruited from 16 institutions, were enrolled in the retrospective study. Patients had smaller tumors at diagnosis; only 15% of patients had tumors larger than 5 cm. The number of patients who had no axillary lymph node involvement was 203 (32.7%). Ninety-three patients (15.0%) had metastatic disease at diagnosis. Patients were characterized by a higher fraction of pure lobular carcinomas (75.3%). The tumors of the elderly patients were also more frequently estrogen receptor (ER) positive (75.2%) and progesterone receptor (PR) positive (67.3%). The local and systemic therapies for breast cancer differed according to age. An association between age and overall survival has not been demonstrated in elderly patients with breast cancer. In conclusion, the biologic behavior of older patients with breast cancer differs from younger patients, and older patients receive different treatments.
1 Department of Medical Oncology, Dicle University, Diyarbakir, Turkey.
Ali
A
Inal
Tulay
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Sebnem
S
Yaman
Selcuk Cemil
SC
Ozturk
Caglayan
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Geredeli
Mehmet
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Bilici
Mevlude
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Inanc
Hakan
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Harputoglu
Umut
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Demirci
Ozan
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Balakan
Havva Yesil
HY
Cınkır
Suleyman
S
Alıcı
Dilsen
D
Colak
Ozlem Uysal
OU
Sonmez
Gamze
G
Goksel
Gamze Gokoz
GG
Dogu
Huseyin
H
Engin
Olcun Umit
OU
Unal
Tulay
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Suleyman
S
Buyukberber
Cem Melih
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Boruban
Abdurrahman
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Isıkdogan
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D018567:Breast Neoplasms, Male / Q000401:mortality / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009362:Neoplasm Metastasis; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis