Replicative Capacity of MERS Coronavirus in Livestock Cell Lines.
Replicative capacity of Middle East respiratory syndrome coronavirus (MERS-CoV) was assessed in cell lines derived from livestock and peridomestic small mammals on the Arabian Peninsula. Only cell lines originating from goats and camels showed efficient replication of MERS-CoV. These results provide direction in the search for the intermediate host of MERS-CoV.
Isabella
I
Eckerle
Victor M
VM
Corman
Marcel A
MA
Müller
Matthias
M
Lenk
Rainer G
RG
Ulrich
Christian
C
Drosten
D000818:Animals; D002162:Camelus / Q000821:virology*; D002460:Cell Line; D017934:Coronavirus / Q000502:physiology*; D006041:Goats / Q000821:virology*; D058507:Host Specificity; D054884:Host-Pathogen Interactions; D008877:Middle East; D012367:RNA, Viral / Q000235:genetics*; D014779:Virus Replication / Q000502:physiology*
D012367:RNA, Viral
Arabian Peninsula; MERS; Middle East respiratory syndrome; camels; cell culture; coronavirus; goats; intermediate host; livestock; viruses; zoonoses; zoonosis; zoonotic