Bilateral hippocampal malformation and concurrent granulomatous meningoencephalitis in a dog with refractory epilepsy.
A 5-year-old dog was referred with a history of anorexia and apathy for 3 weeks and acute status epilepticus. Ten weeks later the animal was humanely destroyed due to refractory epilepsy despite anti-epileptic medical treatment. Microscopical examination of the brain revealed bilateral malformation of the dentate gyrus with abnormal gyration. Cornu ammonis segments comprised of sparse pyramidal cells accompanied by marked gliosis. Additionally, there was severe generalized disseminated granulomatous meningoencephalitis, mainly localized to the white matter of the cerebral hemispheres. This is the first description of bilateral hippocampal malformation in a dog.
Institute of Pathology and Forensic Veterinary Medicine, Department for Pathobiology, Veterinärplatz 1, 1210 Vienna, Austria.
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Klang
Clinic for Internal Medicine and Infectious Diseases, Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
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M
Leschnik
Institute of Pathology and Forensic Veterinary Medicine, Department for Pathobiology, Veterinärplatz 1, 1210 Vienna, Austria.
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P
Schmidt
Clinic for Internal Medicine and Infectious Diseases, Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria. Electronic address: akos.pakozdy@vetmeduni.ac.at.
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Pakozdy
D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004827:Epilepsy / Q000473:pathology / Q000662:veterinary*; D005911:Gliosis / Q000473:pathology / Q000662:veterinary*; D006624:Hippocampus / Q000002:abnormalities* / Q000473:pathology; D008590:Meningoencephalitis / Q000473:pathology / Q000662:veterinary*
dog; epilepsy; granulomatous meningoencephalitis; hippocampus malformation