Isolated Chorea Associated with LGI1 Antibody.
BACKGROUND
Leucine-rich glioma inactivated 1 (LGI1) antibody produces a syndrome of limbic encephalitis, hyponatremia, and facio-brachial dystonic seizures that is non-paraneoplastic and responsive to corticosteroids. Parkinsonism, tremor, and generalized chorea are rare manifestations of LGI1, but, when present, commonly accompany other signs of limbic encephalitis.


METHODS
We present a case of LGI1-related isolated chorea in a 53-year-old Japanese male. His chorea responded to high-dose steroids, suggesting a potential role for this synaptic antibody in triggering chorea.


CONCLUSIONS
This case highlights a new treatable etiology of chorea.
Movement Disorders Division, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Ritesh A
RA
Ramdhani
Movement Disorders Division, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Steven J
SJ
Frucht
LGI1 antibody; chorea; pulse steroids; reversible