[Minocycline hydrochloride liposome controlled-release gel improves rat experimental periodontitis].
OBJECTIVE
To evaluate the therapeutic effects of 2% minocycline hydrochloride liposome controlled-release gel on the periodontitis in an established rat periodontitis model.


METHODS
Biocompatibility was tested by oral perfusion sample solution for long-term observation. Minocycline hydrochloride liposome controlled-release gel was utilized to treat the established rat periodontitis model. The rats were selected randomly and divided into three groups: group A (PERIO-treated group), group B (minocycline hydrochloride liposome controlled-release gel treated group), and group C (negative control group). The gingival index (GI) and probing depth (PD) were detected, and the number of mononuclear and broken bone cells were examined after 7, 14, 28, and 56 d.


RESULTS
The minocycline hydrochloride liposome controlled-release gel exhibited excellent biocompatibility based on weight measure and tissue section evaluation. The rats with periodontitis demonstrated that GI, PD, and the number of mononuclear and broken bone cells of group B decreased in 14, 28, and 56 d. Pathological observation showed that new bones and fibers were formed in group B.


CONCLUSIONS
Minocycline hydrochloride liposome controlled-release gel improves rat periodontitis, thereby providing valuable evidence for clinical application.
Dept. of Prosthodontics, Stomatological Hospital of Shandong University, Jinan 250012, China.
Di
D
Liu
Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012, China.
Pishan
P
Yang
State Key Laboratory of Oral Diseases, Dept. of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Deyu
D
Hu
State Key Laboratory of Oral Diseases, Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Fuxiang
F
Liu
D000818:Animals; D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D012534:Dental Scaling; D008081:Liposomes; D008911:Minocycline; D010512:Periodontal Index; D010518:Periodontitis; D051381:Rats
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D008081:Liposomes; D008911:Minocycline