Evolution of resistance to phytoene desaturase and protoporphyrinogen oxidase inhibitors--state of knowledge.
Two major classes of herbicides include inhibitors of protoporphyrinogen oxidase (PPO) and phytoene desaturase (PDS). Plants can evolve resistance to PPO and PDS inhibitors via several mechanisms that include physical changes, resulting in reduced uptake, physiological changes, resulting in compartmentalization or altered translocation, and biochemical changes, resulting in enhanced metabolic degradation or alterations of protein structures, leading to loss of sensitivity to the herbicides. This review discusses the involvement of some of these mechanisms in the various cases of resistance to PDS- and PPO-inhibiting herbicides, and highlights unique aspects of target-site resistance to these herbicides.
Natural Products Utilization Research Unit, United States Department of Agriculture - Agricultural Research Service, University, MS, USA.
Franck E
FE
Dayan
Daniel K
DK
Owens
Patrick J
PJ
Tranel
Christopher
C
Preston
Stephen O
SO
Duke
D004791:Enzyme Inhibitors / Q000494:pharmacology*; D053209:Herbicide Resistance / Q000235:genetics*; D006540:Herbicides / Q000494:pharmacology*; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D057685:Plant Weeds / Q000187:drug effects / Q000235:genetics*; D050768:Protoporphyrinogen Oxidase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; D006540:Herbicides; D010088:Oxidoreductases; C022398:phytoene dehydrogenase; D050768:Protoporphyrinogen Oxidase
aquatic weed management; carotenoids; chlorophylls; codon deletion; codon usage; dual targeting; herbicide resistance; invasive weed; phytoene desaturase; protoporphyrinogen oxidase; somatic mutation