RNA families in Epstein-Barr virus.
Epstein-Barr virus (EBV) is a tumorigenic human γ-herpesvirus, which produces several known structured RNAs with functional importance: two are implicated in latency maintenance and tumorigenic phenotypes, EBER1 and EBER2; a viral small nucleolar RNA (v-snoRNA1) that may generate a small regulatory RNA; and an internal ribosomal entry site in the EBNA1 mRNA. A recent bioinformatics and RNA-Seq study of EBV identified two novel EBV non-coding (nc)RNAs with evolutionary conservation in lymphocryptoviruses and likely functional importance. Both RNAs are transcribed from a repetitive region of the EBV genome (the W repeats) during a highly oncogenic type of viral latency. One novel ncRNA can form a massive (586 nt) hairpin, while the other RNA is generated from a short (81 nt) intron and is found in high abundance in EBV-infected cells.
Howard Hughes Medical Institute; Yale University; Department of Molecular Biophysics and Biochemistry; New Haven, CT USA.
Walter N
WN
Moss
Howard Hughes Medical Institute; Yale University; Department of Molecular Biophysics and Biochemistry; New Haven, CT USA.
Nara
N
Lee
Howard Hughes Medical Institute; Yale University; Department of Molecular Biophysics and Biochemistry; New Haven, CT USA.
Genaro
G
Pimienta
Howard Hughes Medical Institute; Yale University; Department of Molecular Biophysics and Biochemistry; New Haven, CT USA.
Joan A
JA
Steitz
D001483:Base Sequence; D017124:Conserved Sequence; D019143:Evolution, Molecular; D016679:Genome, Viral; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D018143:Lymphocryptovirus / Q000145:classification / Q000235:genetics; D005810:Multigene Family; D010802:Phylogeny; D020537:RNA, Small Nucleolar; D022661:RNA, Untranslated / Q000235:genetics; D012367:RNA, Viral / Q000737:chemistry* / Q000235:genetics*
C099537:Epstein-Barr virus encoded RNA 1; C106732:Epstein-Barr virus encoded RNA 2; D020537:RNA, Small Nucleolar; D022661:RNA, Untranslated; D012367:RNA, Viral
EBER; Epstein–Barr virus; latency; ncRNA; pseudoknot; stable intronic sequence RNA