FeCl3 catalyzed regioselective C-alkylation of indolylnitroalkenes with amino group substituted arenes.
An efficient FeCl3 catalyzed protocol for the synthesis of amino functionalized indolylnitroalkanes from easily available precursor indolylnitroalkenes and substituted amines has been developed. Regioselective C-alkylation in the presence of free amino substituted arenes occurred. The scope of this methodology shows good functional group tolerance, and further, this protocol was used to prepare indolylquinoline derivatives.
Department of Chemistry, National Taiwan Normal University , 88, Sec. 4, Tingchow Road, Taipei, Taiwan 116, R.O.C.
Manoj R
MR
Zanwar
Veerababurao
V
Kavala
Sachin D
SD
Gawande
Chun-Wei
CW
Kuo
Wen-Chang
WC
Huang
Ting-Shen
TS
Kuo
Hsiu-Ni
HN
Huang
Chiu-Hui
CH
He
Ching-Fa
CF
Yao
D000478:Alkylation; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D002712:Chlorides / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D009574:Nitro Compounds / Q000737:chemistry*
D000588:Amines; D002712:Chlorides; D005290:Ferric Compounds; D007211:Indoles; D009574:Nitro Compounds; C024555:ferric chloride