Chronic neutrophilic leukemia with concurrent CSF3R and SETBP1 mutations: single colony clonality studies, in vitro sensitivity to JAK inhibitors and lack of treatment response to ruxolitinib.
Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
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Lasho
Division of Hematology and Oncology, Medical University of South Carolina, Charleston, SC, USA.
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Mims
Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
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Elliott
Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
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Finke
Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
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Pardanani
Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
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Tefferi
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000628:therapy; D002352:Carrier Proteins / Q000235:genetics*; D003131:Combined Modality Therapy; D019008:Drug Resistance, Neoplasm / Q000187:drug effects; D041905:Erythroid Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D066298:In Vitro Techniques; D053614:Janus Kinase 2 / Q000037:antagonists & inhibitors*; D015467:Leukemia, Neutrophilic, Chronic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D009154:Mutation / Q000235:genetics*; D009570:Nitriles; D009687:Nuclear Proteins / Q000235:genetics*; D011379:Prognosis; D011720:Pyrazoles / Q000627:therapeutic use*; D011743:Pyrimidines; D016184:Receptors, Colony-Stimulating Factor / Q000235:genetics*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; C517047:CSF3R protein, human; D002352:Carrier Proteins; D009570:Nitriles; D009687:Nuclear Proteins; D011720:Pyrazoles; D011743:Pyrimidines; D016184:Receptors, Colony-Stimulating Factor; C425066:SETBP1 protein, human; C540383:ruxolitinib; C507924:JAK2 protein, human; D053614:Janus Kinase 2; D006918:Hydroxyurea