Peritoneal Surface Disease Severity Score as a predictor of resectability in the treatment of peritoneal surface malignancies.
BACKGROUND
We evaluated the clinical utility of the Peritoneal Surface Disease Severity Score (PSDSS) as a preoperative predictor of resectability in the treatment of peritoneal surface malignancies.


METHODS
Forty-nine patients were selected for cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) and were stratified according to the PSDSS retrospectively.


RESULTS
Of 52 cytoreductive surgeries performed in 49 patients, HIPEC was performed in 33 cases (63%). We analyzed 31 cases of appendiceal and colorectal cancer patients who underwent CRS and HIPEC and 12 who underwent CRS only. 68% of the patients in whom CRS and HIPEC was performed were classified as PSDSS stage I or II. Contrastingly, all patients in whom CRS and HIPEC was unachievable were scored as PSDSS stage III or IV.


CONCLUSIONS
The outcomes of this study suggest that the PSDSS can be used as a preoperative assessment tool to predict disease resectability in the treatment of peritoneal surface malignancies.
Department of Surgery, Section of Surgical Oncology, St John Hospital and Medical Center, Van Elslander Cancer Center, Detroit, MI 48236, USA. Electronic address: william.yoon@stjohn.org.
William
W
Yoon
Department of Surgery, Section of Surgical Oncology, St John Hospital and Medical Center, Van Elslander Cancer Center, Detroit, MI 48236, USA.
Amer
A
Alame
Department of Surgery, Section of Surgical Oncology, St John Hospital and Medical Center, Van Elslander Cancer Center, Detroit, MI 48236, USA.
Richard
R
Berri
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001063:Appendiceal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010537:Peritoneum / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
D000970:Antineoplastic Agents
Complete cytoreduction; Cytoreductive surgery; Hyperthermic intraperitoneal chemotherapy (HIPEC); Peritoneal surface disease severity score (PSDSS); Peritoneal surface malignancies