Seq and CLIP through the miRNA world.
High-throughput sequencing of RNAs crosslinked to Argonaute proteins reveals not only a multitude of atypical miRNA binding sites but also of miRNA targets with atypical functions, and can be used to infer quantitative models of miRNA-target interaction strength.
Nitish
N
Mittal
Mihaela
M
Zavolan
D000818:Animals; D060565:Argonaute Proteins / Q000235:genetics / Q000378:metabolism*; D001665:Binding Sites / Q000235:genetics; D059014:High-Throughput Nucleotide Sequencing / Q000379:methods; D006801:Humans; D047468:Immunoprecipitation / Q000379:methods*; D035683:MicroRNAs / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics; D017423:Sequence Analysis, RNA / Q000379:methods*
D060565:Argonaute Proteins; D035683:MicroRNAs; D022661:RNA, Untranslated