Human Papillomavirus (HPV) infection in women participating in cervical cancer screening from 2006 to 2010 in Shenzhen City, South China.
OBJECTIVE
Human papillomavirus (HPV) infection plays an important role in the development of cervical cancer, but the prevalence of HPV infection in women of Shenzhen city remains unclear. The present study was performed to describe the change of cervical HPV infection in females who participated in voluntary cervical cancer screening from 2006 to 2010 in Shenzhen city, China.


METHODS
A total of 4, 413 women were recruited. HPV infections were genotyped by polymerase chain reaction (PCR) and reversed dot blot hybridization in Shenzhen Maternity and Child Health Hospital.


RESULTS
The prevalence of HPV infection was 13.8%. The five most commonly found HPV types were HPV16 (3.47%), HPV58 (1.68%), HPV33 (1.38%), HPV43 (1.36%) and HPV18 (1.27%). The secular trends of major HPV type-specific were diverse. Among of them, the prevalence of HPV18 increased sharply while others increased slowly or even decreased in the period. The change of total HPV, single HPV and multiple HPV infection were similar during the five years.


CONCLUSIONS
Our findings suggested that HPV infection is common with HPV16 and HPV 58 as the primary subtypes in women in Shenzhen city. The prevalence of HPV 18 infection is increasing faster than any others, which will lead it to be one of the main subtypes in this city in the future.
Shenzhen Maternity and Child Health Hospitals, Shenzhen, China E-mail : zhhliu2012@126.com.
Yue-Yun
YY
Wang
Li
L
Li
Sheng
S
Wei
Ji
J
Peng
Shi-Xin
SX
Yuan
Jian-Sheng
JS
Xie
Zhi-Hua
ZH
Liu
D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000235:genetics; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000235:genetics / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011379:Prognosis; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000235:genetics / Q000821:virology*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000150:complications / Q000235:genetics / Q000821:virology*
D004279:DNA, Viral