Biflavanones with anti-proliferative activity against eight human solid tumor cell lines from Stellera chamaejasme.
Six 3,3″-biflavanones, including a new compound isochamaejasmenin C (1), were isolated from EtOH extracts of the roots of Stellera chamaejasme L. Their structures were elucidated on the basis of spectroscopic methods, including HR-ESI-MS and 2D NMR techniques. The absolute configurations on 2, 3, 3″, and 2″ of compounds 1, 3, and 6, which represent three geometry types of these compounds, were determined by TDDFT quantum chemical calculations of their ECD spectra. All compounds were evaluated for their cytotoxicities against eight human solid tumor cell lines and compounds 2, 4, and 6 showed strong anti-proliferative effects against all these cell lines with IC50 values ranging from 1.08 to 15.97 μM, which were in the same range as the positive control paclitaxel.
School of Medicine, Zhejiang University City College, 48 Huzhou Rd., Hangzhou 310015, China.
Jie
J
Li
School of Medicine, Zhejiang University City College, 48 Huzhou Rd., Hangzhou 310015, China.
Jiao-Jiao
JJ
Zhang
School of Medicine, Zhejiang University City College, 48 Huzhou Rd., Hangzhou 310015, China.
Xiao-Xiao
XX
Pang
School of Medicine, Zhejiang University City College, 48 Huzhou Rd., Hangzhou 310015, China.
Xi-Lei
XL
ZhengChen
College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Rd., Hangzhou 310058, China. Electronic address: lsgan@zju.edu.cn.
Li-She
LS
Gan
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D017239:Paclitaxel; D029645:Thymelaeaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D044950:Flavanones; C000595288:isochamaejasmenin C; D017239:Paclitaxel
Cytotoxic activity; Isochamaejasmenin C; Stellera chamaejasme; TDDFT