Case of keratitis caused by Streptomyces thermocarboxydus.
We describe a case of keratitis caused by Streptomyces thermocarboxydus and report the usefulness of molecular analysis in identifying the exact species of Streptomyces. A 50-year-old man was diagnosed with keratitis caused by Streptomyces sp. which was identified as S. thermocarboxydus by sequencing the 16S rDNA. He had no history of trauma or systemic diseases. He was initially treated with topical beta-lactams and fluoroquinolones, and systemic beta-lactams but the keratitis did not improve. His vision improved significantly after topical erythromycin (5 mg/ml) and oral minocycline (200 mg/day) therapy. Our findings demonstrate that molecular analysis can be used to identify the exact Streptomyces species causing the keratitis. This then allowed us to determine the susceptibility of this species to different antibacterial drugs which were used to treat our patient successfully.
Department of Ophthalmology, Gifu Municipal Hospital, Japan. Electronic address: hkawa-gif@umin.ac.jp.
Hideaki
H
Kawakami
Department of Ophthalmology, Gifu Municipal Hospital, Japan.
Hiroko
H
Inuzuka
Department of Ophthalmology, Gifu University Graduate School of Medicine, Japan.
Kiyofumi
K
Mochizuki
Department of Clinical Laboratory, Gifu Municipal Hospital, Japan.
Toshihiro
T
Muto
Department of Microbiology, Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Japan.
Kiyofumi
K
Ohkusu
Medical Mycology Research Center, Chiba University, Japan.
Takashi
T
Yaguchi
Department of Infection Control and Prevention, Aichi Medical University, Japan.
Yuka
Y
Yamagishi
Department of Infection Control and Prevention, Aichi Medical University, Japan.
Hiroshige
H
Mikamo
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D013302:Streptomyces / Q000187:drug effects
D000900:Anti-Bacterial Agents
Keratitis; Molecular analysis; Streptomyces thermocarboxydus; Susceptibility