Upregulated miR-106a plays an oncogenic role in pancreatic cancer.
Carcinogenesis is a complex process during which cells undergo genetic and epigenetic alterations. MicroRNAs control gene expression by negatively regulating protein-coding mRNAs. Several reports demonstrated that miR-106a is up-regulated in gastric and colorectal cancers and promotes tumor progression. In contrast, in glioma miR-106a plays the role of a tumor suppressor gene rather than an oncogene. Here we demonstrate that a high level of miR-106a expression is present in pancreatic cancer. Furthermore, our investigation shows that miR-106a has an oncogenic role in pancreatic tumorigenesis by promoting cancer cell proliferation, epithelial-mesenchymal transition and invasion by targeting tissue inhibitors of metalloproteinase 2 (TIMP-2). MiR-106a could be a critical therapeutic target in pancreatic cancer.
Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Pei
P
Li
Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Qinhong
Q
Xu
Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Dong
D
Zhang
Department of General Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Xuqi
X
Li
Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Liang
L
Han
Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Jianjun
J
Lei
Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Wanxing
W
Duan
Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Qingyong
Q
Ma
Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
Zheng
Z
Wu
Department of Hepatobiliary Surgery, First Affiliated Hospital Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China. Electronic address: zheng.wang11@mail.xjtu.edu.cn.
Zheng
Z
Wang
D001483:Base Sequence; D001665:Binding Sites; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D059447:Cell Cycle Checkpoints; D049109:Cell Proliferation; D002470:Cell Survival; D058750:Epithelial-Mesenchymal Transition; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009857:Oncogenes; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D034622:RNA Interference; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation
D015815:Cell Adhesion Molecules; C542541:MIRN106 microRNA, human; D035683:MicroRNAs; C560823:TIMP2 protein, human; D019716:Tissue Inhibitor of Metalloproteinase-2; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9
Cell invasion; Pancreatic cancer; Tissue inhibitors of metalloproteinase 2; miR-106a; miRNA