Detrimental role of humoral signalling in cardio-renal cross-talk.
In critically ill patients, any acute organ injury is associated with a sudden change of circulating factors that may play a role in distant organ dysfunction through a complex cross-talk. In this issue, Virzì and colleagues discuss the relevance of humoral signalling between heart and kidney, focusing on type 1 and type 3 cardio-renal syndrome. We herein review the mechanisms of heart-kidney cross-talk, discussing the role of circulating detrimental mediators in the pathogenetic mechanisms of cardio-renal syndrome.
Vincenzo
V
Cantaluppi
Sergio
S
Dellepiane
Alessandro D
AD
Quercia
Silvia
S
Ferrario
D058186:Acute Kidney Injury / Q000503:physiopathology*; D059347:Cardio-Renal Syndrome; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*