Pharmaceutical point of view on parenteral nutrition.
Parenteral nutrition--a form of administering nutrients, electrolytes, trace elements, vitamins, and water--is a widely used mode of therapy applied in many diseases, in patients of different ages both at home and in hospital. The success of nutritional therapy depends chiefly on proper determination of the patient's energetic and electrolytic needs as well as preparation and administration of a safe nutritional mixture. As a parenterally administered drug, it is expected to be microbiologically and physicochemically stable, with all of the components compatible with each other. It is very difficult to obtain a stable nutritional mixture due to the fact that it is a complex, two-phase drug. Also, the risk of incompatibility between mixture components and packaging should be taken into consideration and possibly eliminated. Since parenteral nutrition is a part of therapy, simultaneous use of drugs may cause pharmacokinetic and pharmacodynamic interactions as well as those with the pharmaceutical phase. The aim of this paper is to discuss such aspects of parenteral nutrition as mixture stability, methodology, and methods for determining the stability of nutritional mixtures and drugs added to them.
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Poznań, Poland.
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Stawny
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Poznań, Poland.
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Olijarczyk
School of Pharmacy, De Montfort University, The Gateway, Leicester LE19 BH, UK.
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Jaroszkiewicz
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, 6 Grunwaldzka, 60-780 Poznań, Poland.
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Jelińska
D004358:Drug Therapy / Q000379:methods*; D018565:Food-Drug Interactions; D006801:Humans; D009753:Nutritive Value; D057947:Parenteral Nutrition Solutions / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016331:Parenteral Nutrition, Home
D057947:Parenteral Nutrition Solutions