Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone.
Literature data indicate that the infertility in women with polycystic ovary syndrome (PCOS) is not only attributed to anovulation but also to endometrial dysfunction. Endometrial biopsies were performed in the proliferative and secretory phases of women with normal cycle and in women with PCOS before and after oral treatment with micronized progesterone. After the treatment, the endometrium of the women with PCOS exhibited a lower number of glands and thicker luminal epithelium compared to the normal women in the secretory phase. In addition, the PCOS group exhibited reduced integrin and MECA-79 immunoexpression during the secretory phase. The expression of E-cadherin was higher in the PCOS and the expression of intercellular adhesion molecule 1 was lower in PCOS, during the secretory and proliferative phases, respectively. Also, there is a negative correlation with MECA-79 and integrin expression and body mass index. Conventional doses of progesterone may not be enough to correct the changes of endometrial histomorphology and the receptive markers of PCOS-bearing women. The obesity may be a factor that interferes with this response.
Departamento Materno Infantil, Centro de Ciências da Saúde, Universidade Federal do Piauí, UFPI, Teresina, Brazil.
Ione Maria Ribeiro Soares
IM
Lopes
Departamento de Ginecologia, Departamento de Ginecologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, EPM/UNIFESP, Brazil.
Carla Cristina
CC
Maganhin
Departamento de Farmacologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, USP, São Paulo, Brazil.
Ricardo Martins
RM
Oliveira-Filho
Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina da Universidade de São Paulo, FMUSP, São Paulo, Brazil ricardossimoes@hotmail.com.
Ricardo Santos
RS
Simões
Departamento de Ginecologia, Departamento de Ginecologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, EPM/UNIFESP, Brazil.
Manuel Jesus
MJ
Simões
Departamento de Ginecologia, Departamento de Ginecologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, EPM/UNIFESP, Brazil.
Margareth Chiharu
MC
Iwata
Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina da Universidade de São Paulo, FMUSP, São Paulo, Brazil.
Edmund Chada
EC
Baracat
Departamento de Ginecologia, Departamento de Ginecologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, EPM/UNIFESP, Brazil Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina da Universidade de São Paulo, FMUSP, São Paulo, Brazil.
José Maria
JM
Soares
cell adhesion molecules; endometrium; polycystic ovary syndrome