Association of aging, arterial stiffness, and cardiovascular disease: a review.
Coronary heart disease (CHD) is the leading cause of morbidity and mortality in the western world. Primary and secondary prevention strategies have improved tremendously. Conventional risk factors are identified and treated with intensive pharmacotherapy. Despite these measures, the incidence of CHD is on the rise in developed countries. Arterial stiffness has been identified as an independent risk factor for the development of CHD, both in the general population and in those with established CHD. This review examines the association of arterial stiffness with cardiovascular disease.
From the *Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom; †Institute of Ageing and Health, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, United Kingdom; ‡Cardiothoracic Centre, Freeman Hospital, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom; §Department of Biochemistry, Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle-upon-Tyne, United Kingdom.
Murugapathy
M
Veerasamy
Gary A
GA
Ford
Dermot
D
Neely
Alan
A
Bagnall
Guy
G
MacGowan
Rajiv
R
Das
Vijay
V
Kunadian
D000375:Aging / Q000502:physiology*; D003327:Coronary Disease / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D059289:Vascular Stiffness