Use of 111In-pentetreotide scan in a subject with treatment refractory atypical meningioma.
A 57-year-old man with a history of multiple recurrent atypical meningiomas (World Health Organization grade II) had several surgical resections including γ knife resection of the parafalcine meningioma, followed with a stereotactic radiosurgical ablation. Despite these treatments, an MRI scan performed 7 months later showed progression of the disease. The patient remained symptomatic with intermittent severe headaches associated with nausea, vomiting, and visual disturbance. He had a positive In-pentetreotide indicating the presence of somatostatin receptors. Therefore, he was placed on systemic Sandostatin (octreotide acetate) treatment, and at follow-up, he was clinically responsive to treatment.
From the *Division of Nuclear Medicine, Department of Radiology, and †Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, PA.
Gonca G
GG
Bural
Frank
F
Lieberman
James M
JM
Mountz
D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy*; D008579:Meningioma / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy*; D008875:Middle Aged; D016634:Radiosurgery; D013004:Somatostatin / Q000031:analogs & derivatives*; D017211:Treatment Failure
D013004:Somatostatin; C081788:pentetreotide