Searching for a successful HDL-based treatment strategy.
Despite strong evidence that HDL-cholesterol levels predict atherosclerotic events in a population, attempts at using and HDL-based treatment strategy have not yet been successful. Most of the efforts to date have focused on raising plasma HDL-cholesterol levels. This brief review focuses on a different strategy, which is based on the use of 18-amino acid apoA-I-mimetic peptides. The story of these peptides spans decades and illustrates the remarkable complexity of HDL-based treatment strategies, but suggests that such a strategy may still be successful.
Srinivasa T
ST
Reddy
Mohamad
M
Navab
G M
GM
Anantharamaiah
Alan M
AM
Fogelman
D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood*; D006801:Humans; D010455:Peptides / Q000627:therapeutic use*; D057786:Peptidomimetics / Q000627:therapeutic use*
D008076:Cholesterol, HDL; D010455:Peptides; D057786:Peptidomimetics; C582295:apolipoprotein A-I mimetic peptide 4F