X-ray diffraction study confirms intra-adipocitary lipid crystallization after lipocryolysis stimulus.
Lipocryolysis always claimed localized-fat-reduction to be a consequence of local apoptotic adipocyte destruction triggered by intracellular triglyceride crystallization. The idea is now under debate, for it has been suggested that the physical changes occurring in adipocytes after lipocryolysis could be better explained by a lipid gel-like transition process rather than by lipid crystallization. Since a) lipocryolysis claims apoptosis to be the key to adipocyte destruction and clinical-result achievement and b) it considers crystallization to be a necessary step for the apoptotic stimulus unleashing, any effort to untangle, prove or discard this process is very important.
Instituto de Investigaciones para las Especialidades Estéticas y del Envejecimiento, Barcelona; Spain. portatil@ageback.es.
H
H
Pinto
Centre de Recerca en Metabolisme, Barcelona (CEREMET).
D
D
Ricart-Jane
Centre de Recerca en Metabolisme, Barcelona (CEREMET).
E
E
Pardina
D017667:Adipocytes / Q000737:chemistry / Q000166:cytology*; D000818:Animals; D017209:Apoptosis; D002478:Cells, Cultured; D003080:Cold Temperature; D003460:Crystallization; D008055:Lipids / Q000737:chemistry*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000737:chemistry; D014961:X-Ray Diffraction
D008055:Lipids; D014280:Triglycerides