Paradigm shift from alkaline (earth) metals to early transition metals in fluoroorganometal chemistry: perfluoroalkyl titanocene(III) reagents prepared via not titanocene(II) but titanocene(III) species.
Perfluoroalkyl (RF) titanocene reagents [Cp2Ti(III)RF] synthesized via [Cp2Ti(III)Cl] rather than [Cp2Ti(II)] show new types of perfluoroalkylation reactions. The [Cp2Ti(III)RF] reagents exhibit a wide variety of reactivity with carbonyl compounds including esters and nitriles, and selectivities far higher than those reported for conventional RFLi and RFMgX reagents.
Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552 (Japan), Fax: (+81) 3-5734-2776.
Motohiro
M
Fujiu
Ryota
R
Hashimoto
Yuzo
Y
Nakamura
Kohsuke
K
Aikawa
Shigekazu
S
Ito
Koichi
K
Mikami
D007202:Indicators and Reagents / Q000737:chemistry*; D008673:Metals, Alkaline Earth / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*; D028561:Transition Elements / Q000737:chemistry*
D007202:Indicators and Reagents; D008673:Metals, Alkaline Earth; D009942:Organometallic Compounds; D028561:Transition Elements; C406884:titanocene; D014025:Titanium
alkylation; fluorine; metallocenes; synthetic methods; titanium