Clinical implications of pathogenic calcium crystals.
OBJECTIVE
The role of intraarticular calcifications has been challenged over the past years, with respect to cartilage destruction, especially in osteoarthritis.


RESULTS
Main themes reviewed in this article will discuss prevalence of articular cartilage calcifications, mechanisms of cartilage calcifications, and mostly the pathogenic role of both calcium pyrophosphate and basic calcium phosphate crystals.


CONCLUSIONS
A direct pathogenic role of both calcium crystals has been depicted, in cartilage as a crystal-induced stress, or via acute or chronic crystal-induced synovitis.
aSorbonne Paris Cité, University Paris Diderot bInserm, UMR S606/1332, Centre Viggo Petersen, Hôpital Lariboisière cAP-HP, Hôpital Lariboisière, Pôle Appareil Locomoteur, Service de Rhumatologie A, Centre Viggo Petersen, Paris, France.
Frédéric
F
Lioté
Hang-Korng
HK
Ea
D000818:Animals; D002130:Calcium Phosphates / Q000737:chemistry / Q000378:metabolism*; D002131:Calcium Pyrophosphate / Q000737:chemistry / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism; D002805:Chondrocalcinosis / Q000209:etiology / Q000378:metabolism; D019902:Chondrocytes / Q000378:metabolism; D003460:Crystallization; D006801:Humans; D010003:Osteoarthritis / Q000209:etiology / Q000378:metabolism
D002130:Calcium Phosphates; D002131:Calcium Pyrophosphate