Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series.
Paracetamol was reported to be effective for patent ductus arteriosus (PDA) closure. We present a case series of PDA closure by paracetamol in seven premature infants. During the treatment, paracetamol blood levels did not exceed the recommended levels for analgesia and hyperthermia in six tested infants. None of the patients demonstrated significant disturbances of liver function.
Department of Neonatology, Carmel Medical Center , Haifa, Israel .
Irena
I
Kessel
Dan
D
Waisman
Karen
K
Lavie-Nevo
Marcelo
M
Golzman
Avraham
A
Lorber
Avi
A
Rotschild
D000082:Acetaminophen / Q000097:blood / Q000627:therapeutic use*; D018712:Analgesics, Non-Narcotic / Q000097:blood / Q000627:therapeutic use*; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000097:blood / Q000188:drug therapy*
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen
Blood level; closure; paracetamol; patent ductus arteriosus