Regulation and function of histone acetyltransferase MOF.
The mammalian MOF (male absent on the first), a member of the MYST (MOZ, YBF2, SAS2, and Tip60) family of histone acetyltransferases (HATs), is the major enzyme that catalyzes the acetylation of histone H4 on lysine 16. Acetylation of K16 is a prevalent mark associated with chromatin decondensation. MOF has recently been shown to play an essential role in maintaining normal cell functions. In this study, we discuss the important roles of MOF in DNA damage repair, apoptosis, and tumorigenesis. We also analyze the role of MOF as a key regulator of the core transcriptional network of embryonic stem cells.
Key Laboratory of Experimental Teratology, Ministry of Education, Department of Cell Biology, Shandong University School of Medicine, Jinan, 250012, China.
Yang
Y
Yang
Xiaofei
X
Han
Jingyun
J
Guan
Xiangzhi
X
Li
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D053595:Embryonic Stem Cells / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D051548:Histone Acetyltransferases / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology
D051548:Histone Acetyltransferases; C496552:KAT8 protein, human; C000622683:Kat8 protein, mouse