The correlation of the total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase activity (PON1) with smoking.
OBJECTIVE
In this study, we aimed to assess the total antioxidant status (TAS), total oxidant status (TOS) and paraoxonase activity (PON1) in smokers and nonsmokers.


METHODS
This cross-sectional analytical study was conducted on 100 smokers and 100 nonsmokers. Low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), total cholesterol (TC), triglyceride (TG), fasting blood glucose (FBG), TAS, TOS and PON1 levels of the participants were determined in the blood samples. TAS and TOS were determined by using the automated measurement method. Paraoxon was used as a substrate for measuring PON1 activity.


RESULTS
A statistically significant difference could not be found between smokers and nonsmokers in terms of mean FBG, LDL-c, HDL-c, TC, TG, TAS, TOS, PON1, oxidative stress index (OSI) and body mass index (BMI). Mean TAS and TOS levels were higher in men than women (p=0.001). As age (p=0.022) and age to start smoking (p=0.023) increased, TOS level decreased. As the age to start smoking (p=0.001) increased, TAS level decreased whereas as BMI (p=0.001) increased, TAS level also increased. A statistically significant relationship could not be established between age, age to start smoking, duration and amount of smoking, dependence score and BMI and PON1 (p>0.05).


CONCLUSIONS
In our study, although no significant correlation could be established between smokers and nonsmokers in terms of mean TAS, TOS and PON1, it is a fact that TAS, TOS and PON1 in the organism are affected by many factors and therefore there is a need for more extensive studies in this regard.
Department of Family Medicine, Meram Medical Faculty, University of Konya, Turkey. Electronic address: halilraziye@hotmail.com.
Raziye
R
Aslan
Department of Family Medicine, Meram Medical Faculty, University of Konya, Turkey. Electronic address: ruhuse@yahoo.com.
Ruhusen
R
Kutlu
Department of Family Medicine, Meram Medical Faculty, University of Konya, Turkey. Electronic address: selmacivi@yahoo.com.
Selma
S
Civi
Department of Biochemistry, Meram Medical Faculty, University of Konya, Turkey. Electronic address: erkan1452@mynet.com.
Erkan
E
Tasyurek
D000328:Adult; D000367:Age Factors; D000975:Antioxidants / Q000378:metabolism*; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D015992:Body Mass Index; D003710:Demography; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism*; D012907:Smoking / Q000378:metabolism*; D055815:Young Adult
D000975:Antioxidants; D016877:Oxidants; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
Paraoxonase; Smoking; Total antioxidant status; Total oxidant status