Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper.
A new pyridine alkaloid-coupled iridoid glucoside, dipasperoside A (1), and 20 known compounds (2–21) were isolated from a water extract of Dipsacus asper roots. Compound 1 possessed a unique structural feature with a nicotinic acid nucleus coupled through C-5 with C-7 of a secoiridoid/iridoid glucoside dimer, and esterified with a C-7 hydroxyl group of an iridoid glucoside monomer. All isolates were evaluated for their inhibitory activity against nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated murine macrophage cell line, RAW264.7.
Feng
F
Li
Ken
K
Tanaka
Shiro
S
Watanabe
Yasuhiro
Y
Tezuka
Ikuo
I
Saiki
D000470:Alkaloids / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D049917:Dipsacaceae / Q000737:chemistry*; D005960:Glucosides / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D039823:Iridoids / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D051379:Mice; D009569:Nitric Oxide / Q000276:immunology; D018517:Plant Roots / Q000737:chemistry; D011725:Pyridines / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D005960:Glucosides; D039823:Iridoids; D008070:Lipopolysaccharides; D011725:Pyridines; D009569:Nitric Oxide; C023666:pyridine