[Certain aspects of therapy of acute hepatic insufficiency].
The author analysed and summarized available information on acute hepatic insufficiency (AHI) with reference to its diagnostics and treatment. The principal cause of AHI is hepatitis and alcohol-induced lesions in the liver, the main pathogenetic mechanisms are hepatocyte necrosis, apoptosis, and necrapoptosis, clinical manifestations include jaundice, coagulopathy and hepatic encephalopathy. Special emphasis is laid on the role of cytokines. Liver transplantation is the sole radical method for the treatment of AHI despite a variety of other therapeutic modalities. Positive effect of efferent and gravitational treatment is confirmed Survival in AHI depends on the regenerative potential of the liver. Prognosis of AHI is individual even though many scales and criteria were proposed.
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Plekhanov
D000208:Acute Disease; D048550:Hepatic Insufficiency / Q000628:therapy*; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D011379:Prognosis; D016060:Sorption Detoxification / Q000379:methods*