Well-differentiated pediatric glial neoplasms with features of oligodendroglioma, angiocentric glioma and dysembryoplastic neuroepithelial tumors: a morphological diagnostic challenge.
OBJECTIVE
Oligodendrogliomas are rare in the pediatric population, and most oligodendroglioma-like tumors in this age group may belong to other entities. In addition, accurate diagnosis and grading of such lesions using criteria developed for adult oligodendrogliomas prove difficult, and often controversial.


METHODS
During a study of tumors previously diagnosed as pediatric oligodendroglioma, we identified four tumors displayed features of that resembled oligodendroglioma, angiocentric glioma and dysembryoplastic neuroepithelial tumor but could not be classified as either one of these entities. Ther clinical, histological and immunohistochemical features of these cases were investigated in this study.


RESULTS
Two male (both 9 years old) and two female (ages 4 years and 20 months) patients presented with new onset of seizures. All patients were treated surgically, and two required reoperation. Histologically, the tumors were well-differentiated glial neoplasms with focal angiocentric pattern, delicate vascularity, diffuse growth, infiltrative margins, cortical nodules, focal myxoid areas, and leptomeningeal extension. Immunohistochemical studies showed diffuse nuclear positivity with Olig-2 and GFAP antibodies, whereas staining with neuronal markers, EMA, p53, and IDH1 were negative. Fluorescent in-situ hybridization analysis demonstrated intact 1p/19q in all tumors, and there was no ultrastructural evidence of ependymal differentiation. All patients were alive with disease with a mean follow-up of 112 months.


CONCLUSIONS
These four cases illustrate the morphological diversity of well-differentiated, oligodendroglioma-like glial neoplasms and the uncertainty in their classification among pediatric tumors.
Department of Pathology, Cumhuriyet University, Faculty of Medicine, SİVAS, TURKEY.
Hande
H
Keser
Michael
M
Barnes
Gregory
G
Moes
Han Sung
HS
Lee
Tarık
T
Tıhan
D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D001932:Brain Neoplasms / Q000737:chemistry / Q000145:classification / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D018302:Neoplasms, Neuroepithelial / Q000737:chemistry / Q000145:classification / Q000150:complications / Q000473:pathology* / Q000601:surgery; D009457:Neuroglia / Q000737:chemistry / Q000473:pathology*; D019635:Neurosurgical Procedures; D009837:Oligodendroglioma / Q000737:chemistry / Q000145:classification / Q000150:complications / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D012086:Reoperation; D012640:Seizures / Q000209:etiology; D013724:Teratoma / Q000737:chemistry / Q000145:classification / Q000150:complications / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
D014408:Biomarkers, Tumor