Design, construction and application of a neutron shield for the treatment of diffuse lung metastases in rats using BNCT.
A model of multiple lung metastases in BDIX rats is under study at CNEA (Argentina) to evaluate the feasibility of BNCT for multiple, non-surgically resectable lung metastases. A practical shielding device that comfortably houses a rat, allowing delivery of a therapeutic, uniform dose in lungs while protecting the body from the neutron beam is presented. Based on the final design obtained by numerical simulations, the shield was constructed, experimentally characterized and recently used in the first in vivo experiment at RA-3.
Universidad Favaloro, FICEN, Av. Belgrano 1723 (1093), C.A.B.A., Buenos Aires, Argentina.
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Razetti
Universidad Favaloro, FICEN, Av. Belgrano 1723 (1093), C.A.B.A., Buenos Aires, Argentina; CONICET, Av. Rivadavia 1917 (1033), C.A.B.A., Córdoba, Argentina; Comisión Nacional de Energía Atómica (CNEA), Av. Gral Paz 1499 (1650), Buenos Aires, Argentina.
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Farías
Comisión Nacional de Energía Atómica (CNEA), Av. Gral Paz 1499 (1650), Buenos Aires, Argentina.
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Thorp
CONICET, Av. Rivadavia 1917 (1033), C.A.B.A., Córdoba, Argentina; Comisión Nacional de Energía Atómica (CNEA), Av. Gral Paz 1499 (1650), Buenos Aires, Argentina.
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VA
Trivillin
Comisión Nacional de Energía Atómica (CNEA), Av. Gral Paz 1499 (1650), Buenos Aires, Argentina.
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Pozzi
Comisión Nacional de Energía Atómica (CNEA), Av. Gral Paz 1499 (1650), Buenos Aires, Argentina.
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Curotto
CONICET, Av. Rivadavia 1917 (1033), C.A.B.A., Córdoba, Argentina; Comisión Nacional de Energía Atómica (CNEA), Av. Gral Paz 1499 (1650), Buenos Aires, Argentina.
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Schwint
CONICET, Av. Rivadavia 1917 (1033), C.A.B.A., Córdoba, Argentina; Comisión Nacional de Energía Atómica (CNEA), Av. Gral Paz 1499 (1650), Buenos Aires, Argentina. Electronic address: srgonzal@cnea.gov.ar.
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González
D000818:Animals; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation*; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008175:Lung Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D011835:Radiation Protection / Q000295:instrumentation*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D051381:Rats
Computational dosimetry; Lung cancer; MCNP; Multiple metastatic disease; Neutron attenuation