[Mechanisms of coronary flow recovery in the isolated heart during reperfusion with cardioprotective liposomal emoxipin form].
In the experiments on the isolated perfused rat heart the effects of liposomes, containing different concentrations (0.25 and 0.1 mg/mL) of emoxipine, on coronary flow restoration after total normothermic ischemia and reperfusion were studied. The coronary flow, levels of nitrates and nitrites in the outflowing perfusate from heart and level of free radical processes were assessed, The obtained results showed that 0.1 mg/mL liposomal emoxipine provide with stronger increase coronary flow during reperfusion mostly due to the increase concentration of endothelial nitric oxide compare with treatments at 0.25 mg/mL.
Ia G
IaG
Toropova
L V
LV
Antonova
R A
RA
Mukhamadiiarov
M V
MV
Bogdanov
A S
AS
Golovkin
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D066298:In Vitro Techniques; D008081:Liposomes / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D010847:Picolines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000889:Anti-Arrhythmia Agents; D008081:Liposomes; D009566:Nitrates; D009573:Nitrites; D010847:Picolines; D009569:Nitric Oxide; D008315:Malondialdehyde; C009820:6-methyl-2-ethyl-3-hydroxypyridine