What doesn't kill you makes you stronger: the anti-inflammatory effect of neutrophil respiratory burst.
In this issue of Immunity, Campbell et al. (2014) demonstrate that hypoxia caused by the respiratory burst of infiltrating neutrophils activates hypoxia inducible factor (HIF) in epithelial cells and protects the mucosa cells in an experimental model of inflammatory bowel disease.
Department of Hematology, National University Hospital, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address: borregaard@rh.dk.
Niels
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Borregaard
D000818:Animals; D003092:Colitis / Q000276:immunology*; D000860:Hypoxia / Q000276:immunology*; D009092:Mucous Membrane / Q000378:metabolism*; D009504:Neutrophils / Q000473:pathology*