Letrozole dispersed on poly (vinyl alcohol) anchored maleic anhydride grafted low density polyethylene: a controlled drug delivery system for treatment of breast cancer.
The present work focuses on the design of a drug delivery system for systemic, controlled release of the poorly soluble breast cancer drug, letrozole. The drug delivery system was prepared in two steps: a low density polyethylene (LDPE) substrate surface was grafted with maleic anhydride (MA) via solution grafting technique. Next, the grafted substrate was used to anchor a hydrophilic polymeric drug release system consisting of poly (vinyl alcohol) (PVA). The PVA anchored MA grafted LDPE (PVA/MA-g-LDPE) drug release system was used for the controlled release of letrozole. This system was characterized using ATR-FTIR spectrophotometry, surface profilometry, and scanning electron microscopy. Biocompatibility studies were also carried out. In vitro release studies of letrozole from the system were performed in distilled water and phosphate buffer saline (PBS) at 37°C. Release of ∼90% letrozole from hydrophilic PVA matrix was observed within a period of 35 days. A high correlation coefficient (R(2)=0.99) was seen between the release of letrozole in distilled water and PBS. Cytotoxicity studies using MTT colorimetric assay suggested that all samples were biocompatible. It is concluded that the letrozole delivery system appears to overcome the limitations associated with letrozole by providing enhanced drug dissolution rate, controlled release and improved bioavailability of the incorporated drug and, therefore, seems to have extended therapeutic effects.
Materials Science Centre, Indian Institute of Technology, Kharagpur, West Bengal 721302, India.
Akhtar Jahan
AJ
Siddiqa
School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal 721302, India.
Koel
K
Chaudhury
Materials Science Centre, Indian Institute of Technology, Kharagpur, West Bengal 721302, India. Electronic address: ba@matsc.iitkgp.ernet.in.
Basudam
B
Adhikari
D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D000077289:Letrozole; D008299:Maleic Anhydrides / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D009570:Nitriles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D020959:Polyethylene / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D008299:Maleic Anhydrides; D009570:Nitriles; D014230:Triazoles; D000077289:Letrozole; D020959:Polyethylene; D011142:Polyvinyl Alcohol
Controlled release; In vitro; LDPE; Letrozole; Poly(vinyl alcohol)