Validation of the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4, a simplified severity scale for assessing skin lesions of atopic dermatitis in dogs.
BACKGROUND
Severity scales are used to grade skin lesions in clinical trials for treatment of dogs with atopic dermatitis (AD). At this time, only two scales have been validated, namely the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-3 and the Canine Atopic Dermatitis Lesion Index (CADLI). However, the high number of assessed sites makes the CADESI-3 impractical.


OBJECTIVE
The aim of this study was to develop and validate a fourth version of the CADESI that is simpler and quicker to administer.


METHODS
Body sites, lesions and severity grades were revised by members of the International Committee on Allergic Diseases of Animals (ICADA). The newly designed CADESI-4 was tested for its validity (i.e. content, construct and criterion), reliability (i.e. inter- and intra-observer reliability and internal consistency), responsiveness (i.e. sensitivity to change) and time to administer. Disease severity benchmarks were chosen using receiver operating characteristic methodology.


RESULTS
The CADESI-4 was simplified in comparison to its previous version to comprise 20 body sites typically affected in atopic dogs. Three lesions (erythema, lichenification and alopecia/excoriation) were scored from 0 to 3 at each site. The CADESI-4 had satisfactory validity, reliability and sensitivity to change. On average, the time to administer a CADESI-4 was one-third that of a CADESI-3. Proposed benchmarks for mild, moderate and severe AD skin lesions are 10, 35 and 60, respectively.


CONCLUSIONS
The CADESI-4 is simpler to use and quicker to administer than its previous version. The ICADA recommends the CADESI-4 instead of the CADESI-3 to score skin lesions of AD in dogs enrolled in clinical trials.
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC, 27607, USA; Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, 27606, USA.
Thierry
T
Olivry
Manolis
M
Saridomichelakis
Tim
T
Nuttall
Emmanuel
E
Bensignor
Craig E
CE
Griffin
Peter B
PB
Hill
D000818:Animals; D003876:Dermatitis, Atopic / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000145:classification / Q000473:pathology*; D004285:Dogs; D010147:Pain Measurement / Q000145:classification / Q000662:veterinary*; D011537:Pruritus / Q000145:classification / Q000662:veterinary*; D015203:Reproducibility of Results; D012720:Severity of Illness Index