Secretory Phospholipase A2 Is Associated with the Odds of Acute Coronary Syndromes through Elevation of Serum Amyloid-A Protein.
In coronary heart disease (CHD), levels of secretory phospholipase A2 (sPLA2) are commonly increased. Serum amyloid-A (SAA) is increased in acute coronary syndromes (ACS) as well. It is needed to verify the hypotheses that sPLA2 is associated with the odds of ACS through elevation of SAA. We conducted a case-control study with 57 male patients with ACS and 30 controls matched by gender category. Levels of sPLA2, SAA, and myeloperoxidase (MPO) were measured by immunoreactive assay on the basis of a double-antibody sandwich technique. Levels of sPLA2, MPO, and SAA were significantly higher in patients than those in controls (11,359.0 ± 10,372.4 pg/mL vs. 1,320.5 ± 654.5 pg/mL, p = 0.00; 438.6 ± 310.7 ng/mL vs. 271.1 ± 176.8 ng/mL, p = 0.01; 10,995.2 ± 2,842.6 ng/mL vs. 3,861.7 ± 3,173.5 ng/mL, p = 0.00). There were significant correlations between age, visceral obesity, MPO, sPLA2, and SAA (r = 0.43; p = 0.00; r = 0.30; p = 0.00; r = 0.28; p = 0.00 and r = 0.53; p = 0.00). On multivariate logistic regression analyses, there were significant and independent associations between sPLA2 and SAA with odds of ACS [OR (95% CI) = 14.2 (2.1 to 98.6), p = 0.00; OR (95% CI) = 44.9 (6.9 to 328.4), p = 0.00]. Our findings suggest that sPLA2 may be associated with the odds of ACS compared with controls through increased inflammation, represented by elevated SAA.
Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Harapan Kita Hospital, National Cardiovascular Centre, Jakarta, Indonesia.
Anwar
A
Santoso
School of Pharmacy, Bandung Institute of Technology, Bandung, Indonesia.
Marita
M
Kaniawati
Department of Internal Medicine, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia.
Syakib
S
Bakri
Department of Physiology, Faculty of Medicine, University of Hasanuddin, Makassar, Indonesia.
Irawan
I
Yusuf
acute coronary syndromes; case–control study; coronary heart disease; myeloperoxidase; odds ratio; secretory phospholipase A2; serum amyloid-A