Chronic granulomatous disease associated with common variable immunodeficiency - 2 clinical cases.
BACKGROUND
Chronic granulomatous disease associated with common variable immunodeficiency (GD-CVID), although well documented, is rare. Granulomatous lesions can affect several organs and are histologically indistinguishable from sarcoidosis.


METHODS
Case 1: A 39-year-old male patient with CVID, asymptomatic although with thrombocytopenia and mediastinal-hilar adenopathies. GD-CVID was diagnosed by bone marrow biopsy. Progressive clinical and radiological improvement was obtained with corticotherapy. Case 2: A 38-year-old male patient with CVID, suffered from asthenia, anorexia, myalgia, lower limbs edemas, and dry cough. He had mediastinal and bilateral hilar adenopathies within which biopsy revealed non-necrotizing granulomatous infiltrate. A spontaneous resolution was detected after 9 months of evolution.


CONCLUSIONS
GD-CVID is rare and can mimetize other pathologies, namely, sarcoidosis; it should therefore be publicized and discussed so that it becomes a general clinical knowledge.
Serviço de Pneumologia, Hospital de Braga, Braga, Portugal. Electronic address: ceciliafpacheco@gmail.com.
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Pacheco
Serviço de Pneumologia, Centro Hospitalar de São João; Faculdade de Medicina da Universidade do Porto, Porto, Portugal.
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Morais
Serviço de Pneumologia, Hospital de Braga, Braga, Portugal.
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Rolo
Serviço de Pneumologia, Hospital de Braga, Braga, Portugal.
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Ferreira
Serviço de Medicina Interna, Hospital de Braga, Braga, Portugal.
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Nabiço
Serviço de Pneumologia, Hospital de Braga, Braga, Portugal.
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Cunha
D000328:Adult; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male
Common variable immunodeficiency; Doença granulomatosa; Granulomas; Granulomatous disease; Imunodeficiência comum variável; Sarcoidose; Sarcoidosis