ACEMg supplementation ameliorates progressive Connexin 26 hearing loss in a child.
Mutations in the gene encoding Connexin 26 are the most common cause of genetic hearing loss. The hearing loss is typically stable but may be progressive. The reason for progression is unknown. Antioxidants have been associated with attenuation of hearing loss from other insults. One antioxidant regimen consists of beta-carotene (metabolized to vitamin A), vitamin C, vitamin E, and magnesium (ACEMg). We present a child with Connexin 26 related hearing loss who experienced progressive hearing loss over 7 years of observation. He was given ACEMg daily for 3 years, during which time his progressive hearing loss was ameliorated.
University of Michigan, Department of Otolaryngology, United States. Electronic address: aarlthat@med.umich.edu.
Aaron
A
Thatcher
University of Florida, Department of Speech, Language, and Hearing Sciences, United States. Electronic address: colleeng@phhp.ufl.edu.
Colleen
C
Le Prell
University of Michigan, Department of Otolaryngology, United States. Electronic address: josef@umich.edu.
Josef
J
Miller
University of Michigan, Department of Otolaryngology, United States. Electronic address: gegreen@med.umich.edu.
Glenn
G
Green
D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage; D001301:Audiometry, Pure-Tone; D002648:Child; D000072259:Connexin 26; D017630:Connexins / Q000235:genetics*; D019587:Dietary Supplements; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014801:Vitamin A / Q000008:administration & dosage; D014810:Vitamin E / Q000008:administration & dosage
D000975:Antioxidants; D017630:Connexins; D014801:Vitamin A; D000072259:Connexin 26; D014810:Vitamin E; D008274:Magnesium; D001205:Ascorbic Acid
Antioxidants; Connexin 26; Genetic hearing loss; Sensorineural hearing loss