Comparison of ghrelin plasma levels between pre and postoperative period in patients submitted to gastric plication associated with fundoplication.
BACKGROUND
The recurrence of the gastroesophageal reflux disease may be related to later postoperative weight gain, therefore increasing the chances of developing columnar metaplasia and cancer. The gastric plication associated with fundoplication can be employed in order to be treating the two issues.


OBJECTIVE
To evaluate the serum ghrelin hormone in pre and postoperatively as well as weight loss and control of reflux disease in patients undergoing gastroplication associated with fundoplication.


METHODS
Was performed laparoscopic gastric plication with fundoplication in eight patients; endoscopic examinations were performed pre and postoperatively as well as blood collection for ghrelin hormonal dosage.


RESULTS
There was control of reflux symptoms and mucosal lesions. Weight loss was significant. Since the change of the hormone ghrelin was not of great significance.


CONCLUSIONS
Gastric plication associated with fundoplication was effective in treating reflux disease with surgical indication and for weight loss in obese patients. Appetite control occurs, but not due to ghrelin, because no significant decrease of its plasmatic levels was observed.
Flávio Heuta
FH
Ivano
Léia de Mello
Lde M
Silva
Gerusa Gabriele
GG
Seniski
Aline Moraes
AM
Menacho
Micheli Angelo
MA
Chigueira
Renar
R
Barros
D000328:Adult; D005260:Female; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000097:blood* / Q000601:surgery*; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011184:Postoperative Period; D011300:Preoperative Care; D013270:Stomach / Q000601:surgery*; D055815:Young Adult
D054439:Ghrelin