Is there a relationship between serum paraoxonase level and epicardial fat tissue thickness?
OBJECTIVE
This study aimed to show the relationship between serum paraoxonase 1 level and the epicardial fat tissue thickness.


METHODS
Two hundred and seven patients without any atherosclerotic disease history were included in this cross-sectional observational study. Correlation analysis was performed to determine the correlation between epicardial fat tissue thickness, which was measured by echocardiography and serum paraoxonase 1 level. Also correlation analysis was performed to show correlation between patients' clinical and laboratory findings and the level of serum paraoxonase 1 (PON 1) and the epicardial fat tissue thickness. Pearson and Spearman test were used for correlation analysis.


RESULTS
No linear correlation between epicardial fat tissue thickness and serum PON 1 found (correlation coefficient: -0.127, p=0.069). When epicardial fat tissue thickness were grouped as 7 mm and over, and below, and 5 mm and over, and below, serum PON 1 level were significantly lower in ≥7 mm group (PON1 : 168.9 U/L) than <7 mm group (PON 1: 253.9 U/L) (p<0.001). Also hypertension prevalence was increased in ≥7 mm group (p=0.001). Serum triglyceride was found to be higher in ≥7 mm group (p=0.014), body mass index was found higher in ≥5 mm group (p=0.006).


CONCLUSIONS
Serum PON 1 level is not correlated with the epicardial fat tissue thickness. But PON 1 level is lower in patients with epicardial fat tissue thickness 7 mm and over. Therefore, increased atherosclerosis progression can be found among patients with 7 mm and higher epicardial fat tissue thickness.
Clinic of Cardiology, Ankara Penal Instution Campus State Hospital; Ankara-Turkey. agertem@hotmail.com.
Ahmet Göktuğ
AG
Ertem
Ali
A
Erayman
Tolga Han
TH
Efe
Bilge
B
Duran Karaduman
Halil Ibrahim
HI
Aydın
Mehmet
M
Bilge
D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D043303:Aryldialkylphosphatase / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging*
D043303:Aryldialkylphosphatase