Resveratrol oligomers inhibit biofilm formation of Escherichia coli O157:H7 and Pseudomonas aeruginosa.
Biofilm formation is closely related to bacterial infection and is also a mechanism of antimicrobial resistance. Hence, the antibiofilm approach provides an alternative to an antibiotic strategy. In this study, the antibiofilm activities of resveratrol (1) and five of its oligomers, namely, ε-viniferin (2), suffruticosol A (3), suffruticosol B (4), vitisin A (5), and vitisin B (6), were investigated against enterohemorrhagic Escherichia coli O157:H7 and Pseudomonas aeruginosa PA14. Vitisin B (6), a stilbenoid tetramer, was found to inhibit biofilm formation by the two bacteria the most effectively and at 5 μg/mL inhibited E. coli O157:H7 biofilm formation by more than 90%.
School of Chemical Engineering, Yeungnam University , Gyeongsan, 712-749, Republic of Korea.
Jin-Hyung
JH
Lee
Yong-Guy
YG
Kim
Shi Yong
SY
Ryu
Moo Hwan
MH
Cho
Jintae
J
Lee
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D019453:Escherichia coli O157 / Q000187:drug effects*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001572:Benzofurans; D010636:Phenols; D013267:Stilbenes; C480486:malvidin-3-O-glucoside-4 vinyl; C091891:epsilon-viniferin; D000077185:Resveratrol