Lack of assocation of glutathione S-transferase T1 gene null and susceptibility to lung cancer in china: a meta-analysis.
BACKGROUND
Variation in metabolic genes is regarded as an important factor in processes leading to cancer. However, the effect of GSTT1 null genotype is divergent in the form of lung cancer.


METHODS
Studies were conducted at different research databases from 1990 to 2013 and the total odds ratio (OR) and 95% confidence interval (CI) were calculated for lung cancer. Review Manager 5.2 and STATE 12 are employed.


RESULTS
Total OR value is calculated from 17 articles with 2,118 cases and 2,915 controls. We discovered no significant increase in lung cancer risk among subjects carrying GSTT1 null genotype [OR = 1.15; 95% CI 0.97-1.36] in this meta- analysis.


CONCLUSIONS
The GSTT1 deletion polymorphism does not have a significant effect on the susceptibility to lung cancer overall in China.
Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, Wuhan, China E-mail : zhengfang@whu.edu.cn.
Hong-Zhou
HZ
Liu
Jie
J
Peng
Fang
F
Zheng
Chun-Hong
CH
Wang
Ming-Jun
MJ
Han
D016022:Case-Control Studies; D002681:China; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
C413545:glutathione S-transferase T1; D005982:Glutathione Transferase