A highly selective chemosensor for Al3+ based on 2-oxo-quinoline-3-carbaldehyde Schiff-base.
A new Schiff-base ligand (1) with good fluorescence response to Al(3+), derived from 2-oxo-quinoline-3-carbaldehyde and nicotinic hydrazide, had been synthesized and investigated in this paper. Spectroscopic investigation revealed that the compound 1 exhibited a high selectivity and sensitivity toward Al(III) ions over other commonly coexisting metal ions in ethanol, and the detection limit of Al(3+) ions is at the parts per billion level. The mass spectra and Job's plot confirmed the 1:1 stoichiometry between 1 and Al(3+). Potential utilization of 1 as intracellular sensors of Al(3+) ions in human cancer (HeLa) cells was also examined by confocal fluorescence microscopy.
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Ke
K
Zhang
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China. Electronic address: yangzy@lzu.edu.cn.
Zheng-yin
ZY
Yang
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China. Electronic address: wangbd@lzu.edu.cn.
Bao-dui
BD
Wang
Institute of Integrated Traditional and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, PR China.
Shao-Bo
SB
Sun
Institute of Integrated Traditional and Western Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, PR China.
Ying-Dong
YD
Li
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Tian-rong
TR
Li
Department of Chemistry, Zhoukou Normal University, Zhoukou 466001, PR China.
Zeng-chen
ZC
Liu
College of Chemistry and Chemical Engineering and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Jun-mei
JM
An
D000535:Aluminum / Q000032:analysis*; D001667:Binding, Competitive; D016923:Cell Death; D002470:Cell Survival; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D000431:Ethanol / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006835:Hydrazones / Q000737:chemistry*; D042541:Intracellular Space / Q000378:metabolism; D066244:Proton Magnetic Resonance Spectroscopy; D011804:Quinolines / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D012996:Solutions; D013050:Spectrometry, Fluorescence
C000594893:2-oxoquinoline-3-carbaldehyde (nicotinoyl) hydrazone; D006835:Hydrazones; D011804:Quinolines; D015363:Quinolones; D012545:Schiff Bases; D012996:Solutions; D000431:Ethanol; D000535:Aluminum; C037219:quinoline; D004121:Dimethyl Sulfoxide
Bioactivity of Al(3+) in living cells; Detection limit; Fluorescence chemosensors; Quinoline derivatives; Sensitivity and selectivity