Description of the vasospasm phenomena following perimesencephalic nonaneurysmal subarachnoid hemorrhage.
BACKGROUND
Perimesencephalic nonaneurysmal subarachnoid hemorrhage (PM-NASAH) is characterized by a benign course compared with aneurysmal SAH. While vasospasm (VS) after aneurysmal SAH is considered responsible for serious complications, VS post-PM-NASAH is not well documented. Our purpose was to characterize the incidence and course of VS among 63 patients--one of the largest databases of PM-NASAH patients with documented blood flow velocities in the literature.


METHODS
Data from 63 patients that were admitted with PM-NASAH from 2000 to 2012 and underwent transcranial Doppler tests to assess cranial vessel flow velocity was analyzed.


RESULTS
On average, the maximal flow velocity was measured on the 7th day after hemorrhage. Higher risk for VS was associated with younger age, female sex, and higher Hunt and Hess scores, a lower risk for patients treated with statins (P < 0.05). Using velocity thresholds for diagnosis of VS, 49.2% showed evidence of VS. This is the first description of blood flow velocities in PM-NASAH. VS average onset was on the 4th day, average cessation on day 15 after hemorrhage. No patients showed clinical manifestation of VS.


CONCLUSIONS
VS post-PM-NASAH is not as rare as previously believed. However, its lack of clinical significance raises questions regarding the need for diagnosis and may suggest a less intensive treatment protocol.
Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.
Daphna
D
Prat
Department of Neurosurgery, Sheba Medical Center, 52621 Tel-Hashomer, Israel.
Oded
O
Goren
Department of Neurosurgery, Sheba Medical Center, 52621 Tel-Hashomer, Israel.
Bela
B
Bruk
Department of Radiology, Sheba Medical Center, 52621 Tel-Hashomer, Israel.
Mati
M
Bakon
Department of Neurosurgery, Sheba Medical Center, 52621 Tel-Hashomer, Israel.
Moshe
M
Hadani
Department of Neurosurgery, Sheba Medical Center, 52621 Tel-Hashomer, Israel.
Sagi
S
Harnof
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D056973:Four-Dimensional Computed Tomography; D006801:Humans; D008297:Male; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D020301:Vasospasm, Intracranial / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*