CYB5A and autophagy-mediated cell death in pancreatic cancer.
The highly invasive and chemoresistant phenotype of pancreatic cancer highlights the urgency to identify prognostic biomarkers and novel therapeutic targets. Recently, we observed a significant correlation between shorter survival and loss of the cytoband 18q22.3. Here we investigated genes encoded by this cytoband, and demonstrated the prognostic value of CYB5A in resected and metastatic patients. Furthermore, our in vitro and in vivo studies clarified CYB5A inhibitory activity of oncogenic phenotypes through autophagy induction. This raises the possibility that inhibition of CYB5A-deregulated downstream pathways, such as those involving TRAF6, may favor autophagy-mediated cancer cell death in selected subgroups of patients.
Department of Medical Oncology; VU University Medical Center; Amsterdam, The Netherlands; Start-Up Unit; University of Pisa; Pisa, Italy.
Elisa
E
Giovannetti
Lombardi Comprehensive Cancer Center; Georgetown University; Department of Oncology; Washington, DC USA.
Giuseppe
G
Giaccone
D001343:Autophagy / Q000502:physiology*; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000502:physiology; D015786:Cytochromes b5 / Q000378:metabolism*; D006801:Humans; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D048029:TNF Receptor-Associated Factor 6 / Q000378:metabolism
C000594834:CYB5A protein, human; D048029:TNF Receptor-Associated Factor 6; D015786:Cytochromes b5
18q22.3 cytoband; CYB5A; TRAF6; pancreatic cancer; prognosis