[Expression of secretoglobin family 2A member 2 in oral lichen planus lesions].
OBJECTIVE
To examine the expression of secretoglobin family 2A member 2 (SCGB2A2) (mammaglobin A, MGB1) in oral lichen planus (OLP) lesions.


METHODS
Sixteen OLP patients and 10 healthy controls were included in this study. The real time reverse transcription-PCR (RT-PCR), Western blotting and immunohistochemistry (IHC) were used to determine the mRNA and protein of SCGB2A2.


RESULTS
Compared with healthy controls (0.48 ± 0.09), the expression of SCGB2A2 protein in OLP lesions significantly increased (1.02 ± 0.11) (P < 0.05).However, the mRNA level of SCGB2A2 in lesions was significantly lower than that in controls (P < 0.05).


CONCLUSIONS
These results suggest that SCGB2A2 may be involved in pathogenesis of OLP.
Department of Oral Medicine,Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China.
Xiao-an
XA
Tao
Jian-yong
JY
Xiao
Qi
Q
Zeng
Email: chengbin@mail.sysu.edu.cn.
Bin
B
Cheng
D000293:Adolescent; D000328:Adult; D000368:Aged; D015153:Blotting, Western; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007150:Immunohistochemistry; D017676:Lichen Planus, Oral / Q000235:genetics / Q000378:metabolism*; D008297:Male; D060785:Mammaglobin A / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055815:Young Adult
D060785:Mammaglobin A; D012333:RNA, Messenger; C556448:SCGB2A2 protein, human