MicroRNA-206: a promising theranostic marker.
MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by binding to the 3` untranslated regions (3`UTR) of their target mRNAs. MiRs were shown to play pivotal roles in tissue development and function and are also involved in the pathogenesis of various diseases including cancer. MicroRNA-206, which belongs to the group of so-called "myomiRs", is one of the most studied miRs thus far. In addition to being involved in skeletal muscle development and pathology, it has also been established that it is involved in the pathogenesis of numerous diseases including heart failure, chronic obstructive pulmonary disease, Alzheimer's disease and various types of cancers. The aim of this review is to provide a complex overview of microRNA-206, including regulating its expression, a brief description of its known functions in skeletal muscle and a complex overview of its roles in the biology and pathology of other tissues, emphasizing its significant diagnostic and therapeutic potential.
1. International Clinical Research Center, Department of Cardiovascular Diseases, St. Anne's University Hospital Brno, Brno, Czech Republic ; 2. Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic ; 3. Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Jan
J
Novák
1. International Clinical Research Center, Department of Cardiovascular Diseases, St. Anne's University Hospital Brno, Brno, Czech Republic.
Peter
P
Kružliak
3. Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic ; 4. Molecular Oncology II, Central European Institute of Technology, Brno, Czech Republic.
Julie
J
Bienertová-Vašků
4. Molecular Oncology II, Central European Institute of Technology, Brno, Czech Republic.
Ondřej
O
Slabý
1. International Clinical Research Center, Department of Cardiovascular Diseases, St. Anne's University Hospital Brno, Brno, Czech Republic.
Miroslav
M
Novák
D000544:Alzheimer Disease / Q000503:physiopathology / Q000628:therapy; D001688:Biological Products / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis*; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology*; D018482:Muscle, Skeletal / Q000254:growth & development; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000628:therapy
D001688:Biological Products; D015415:Biomarkers; C546087:MIRN206 microRNA, human; D035683:MicroRNAs
Theranostic Marker; microRNA-206