Representation of response alternatives in human presupplementary motor area: multi-voxel pattern analysis in a go/no-go task.
A debate exists as to the role of the presupplementary motor area (preSMA) in cognitive control. Recent findings suggest that preSMA plays a central role in conflict resolution and encodes response alternatives as opposed to simply the presence of conflict. Evidence of neuronal heterogeneity within preSMA of non-human primates suggests that univariate analysis of functional MRI data may not provide adequate resolution to fully characterize cognitive control-related responses. Here, multi-voxel pattern analysis (MVPA) is employed to examine the distributed patterns of activity in preSMA associated with both successful go responses and no-go inhibitions. In a go/no-go task, univariate analysis showed undifferentiated activation of preSMA in response to both go and no-go stimuli. However, when an anatomically-defined preSMA ROI was subjected to MVPA, a significant difference in the activation pattern encoded by go as compared to no-go stimuli was observed. These differences in preSMA activation are consistent with the ongoing maintenance and manipulation of stimulus-action representations.
Department of Psychology, George Mason University.
John R
JR
Fedota
Department of Psychiatry, University of Michigan.
Jillian E
JE
Hardee
Department of Psychology, The Pennsylvania State University.
Koraly
K
Pérez-Edgar
Department of Psychology, George Mason University.
James C
JC
Thompson
D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D003657:Decision Making / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D009044:Motor Cortex / Q000098:blood supply / Q000502:physiology*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult
D010100:Oxygen
Cognitive control; Multi-voxel pattern analysis; Response inhibition; preSMA