[Toxicant-induced and drug-induced coma neurotoxicological issues of general anesthesia].
Coma is a pathological condition of unconsciousness in which the patient cannot be awaken by any stimuli (lack of arousal), whose eyes are closed and who has no awareness of self or environment (lack of content of consciousness). Toxic coma is usually transient and disappears after elimination of xenobiotic, and possibly its active metabolites, from the body. Authors present the etiological factors, clinical features and principles of diagnosis and management of toxic coma. Additionally, mechanisms of altered consciousness induced iatrogenically by general anesthetics as well as a brief description of their toxicity are presented.
KlinikaToksykologii i Chorób Srodowiskowych, Wydziału Lekarskiego, Collegium Medicum Uniwersytetu, Jagiellońskiego w Krakowie. wt_poohatek@wp.pl
Krzysztof
K
Ciszowski
Oddzial Toksykologii i Chorób Wewnetrznych z Pododdziałem Detoksykacji, Szpitala Specjalistycznego im Ludwika Rydygiera w Krakowie.
Aneta
A
Mietka-Ciszowska
D000768:Anesthesia, General / Q000009:adverse effects*; D000777:Anesthetics / Q000633:toxicity*; D003128:Coma / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D014474:Unconsciousness / Q000139:chemically induced / Q000175:diagnosis
D000777:Anesthetics