Magnetic pH-responsive nanocarrier with long spacer length and high colloidal stability for controlled delivery of doxorubicin.
A novel magnetic nanocarrier with long spacer length and high colloidal stability has been prepared for effective delivery of doxorubicin (DOX). First, poly(amidoamine) (PAMAM) dendrimer was grown up onto the surface of superparamagnetic iron oxide nanoparticles to increase the loading amount of amine groups. Then, terminal amine groups were functionalized by polyethylene glycol dimethylester to increase the spacer length. Then anticancer drug DOX was covalently attached onto the system by hydrazone bond to forms a pH-sensitive nanocarrier. This system is designed to combine the advantage of magnetic targeting, high drug loading capacity, and controlled release.
Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran. Electronic address: purjavad@sharif.edu.
Ali
A
Pourjavadi
Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Seyed Hassan
SH
Hosseini
Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Mahshid
M
Alizadeh
Department of Physics, Acadia University, Wolfville, NS, Canada.
Craig
C
Bennett
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry*; D003102:Colloids / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D013499:Surface Properties
D000970:Antineoplastic Agents; D003102:Colloids; D050091:Dendrimers; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; C104700:PAMAM Starburst; D004317:Doxorubicin
Dendrimer; Drug delivery; Magnetic nanoparticle; pH-responsive nanocarrier