Redox-driven host-guest interactions allow the controlled release of captured cells on RGD-functionalized surfaces.
A quartz crystal microbalance technique with dissipation monitoring and a complementary optical microscopy technique were used for monitoring the capture and release of specific cells on a surface displaying a bifunctional molecular device, composed of a molecular scaffold endowed with the cell recognition property of an RGD ligand and a β-CD/Fc redox-switchable system.
Université Grenoble Alpes, Département de Chimie Moléculaire, CNRS, UMR 5250, FR 2607, 570 rue de la chimie, B. P. 53, 38400 Grenoble (France).
Dhruv
D
Thakar
Liliane
L
Coche-Guérente
Michaël
M
Claron
Christiane H F
CH
Wenk
Jérôme
J
Dejeu
Pascal
P
Dumy
Pierre
P
Labbé
Didier
D
Boturyn
D002469:Cell Separation; D005296:Ferrous Compounds / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D039302:Integrin alphaVbeta3 / Q000378:metabolism; D000075163:Metallocenes; D008853:Microscopy; D009842:Oligopeptides / Q000737:chemistry*; D010084:Oxidation-Reduction; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000378:metabolism; D058525:Quartz Crystal Microbalance Techniques; D013499:Surface Properties; D047392:beta-Cyclodextrins / Q000737:chemistry
D005296:Ferrous Compounds; D039302:Integrin alphaVbeta3; D000075163:Metallocenes; D009842:Oligopeptides; D010456:Peptides, Cyclic; D047392:beta-Cyclodextrins; C047981:arginyl-glycyl-aspartic acid; C031215:betadex; C004998:ferrocene
RGD peptides; cell capture; host-guest systems; multivalent binding; quartz crystal microbalance