Direct access to isoindolines through tandem Rh(III)-catalyzed alkenylation and cyclization of N-benzyltriflamides.
The rhodium-catalyzed oxidative alkenylation of N-benzyltriflamides with olefins followed by an intramolecular cyclization via C-H bond activation is described. This method results in the direct and efficient synthesis of highly substituted isoindoline frameworks.
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. insukim@skku.edu.
Neeraj Kumar
NK
Mishra
Jihye
J
Park
Satyasheel
S
Sharma
Sangil
S
Han
Mirim
M
Kim
Youngmi
Y
Shin
Jinbong
J
Jang
Jong Hwan
JH
Kwak
Young Hoon
YH
Jung
In Su
IS
Kim
D001596:Benzylamines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*
D001596:Benzylamines; D054833:Isoindoles; D009942:Organometallic Compounds; D013449:Sulfonamides; D012238:Rhodium