Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in chinese han women.
OBJECTIVE
Genetic variation in fibroblast growth factor receptor 2 (FGFR2) is a newly described risk factor for breast cancer. This study aimed to evaluate the association of four single nucleotide polymorphisms (SNPs) in FGFR2 with breast cancer in Han Chinese women.


METHODS
Two hundred three women with breast cancer and 200 breast cancer-free age-matched controls were selected. Four SNPs (rs2981579, rs1219648, rs2420946, and rs2981582) and their haplotypes were analyzed to test for their association with breast cancer susceptibility. The presence of the four FGFR2 SNPs was determined by polymerase chain reaction-restriction fragment length polymorphism analysis.


RESULTS
A statistically significant difference was observed in the frequency of rs2981582 in the FGFR2 gene (p<0.05) between case and control groups. In subjects stratified by menopausal status, rs2981582 TT, rs2420946 AA, and rs1219648 CC were significantly associated with the risk of breast cancer in postmenopausal subjects, but no significant associations between these four SNPs and the risk of breast cancer were identified in premenopausal subjects. Further, there was no significant association between hormone receptor status (estrogen receptor and progesterone receptor) and breast cancer risk. Six common (> 3%) haplotypes were identified. Three of these haplotypes, CGTC (odds ratio [OR], 0.613; 95% confidence interval [CI], 0.457-0.82; p=0.001), TGTC (OR, 6.561; 95% CI, 2.064-20.854; p<0.001), and CATC (OR, 12.645; 95% CI, 1.742-91.799; p=0.001) were significantly associated with breast cancer risk.


CONCLUSIONS
Our findings indicated that the SNP rs2981582 and haplotypes CGTC, TGTC, and CATC in FGFR2 may be associated with an increased risk of breast cancer in Han Chinese women.
Department of Center for Reproductive Medicine, General Hospital, Ningxia Medical University, Ningxia, China. ; Key Laboratory of Fertility Preservation and Maintenance, Ningxia Medical University, Ministry of Education, Ningxia, China.
Chun-Lian
CL
Liu
Department of Clinical Laboratory, Ningxiang Hospital, Hunan, China.
Xiao-Ping
XP
Hu
Department of Surgical Oncology, General Hospital, Ningxia Medical University, Ningxia, China.
Wei-Dong
WD
Guo
Department of Clinical Laboratory, General Hospital, Ningxia Medical University, Ningxia, China.
Li
L
Yang
Key Laboratory of Fertility Preservation and Maintenance, Ningxia Medical University, Ministry of Education, Ningxia, China. ; Department of Medical Genetics and Cell Biology, Ningxia Medical University, Ningxia, China.
Jie
J
Dang
Key Laboratory of Fertility Preservation and Maintenance, Ningxia Medical University, Ministry of Education, Ningxia, China. ; Department of Medical Genetics and Cell Biology, Ningxia Medical University, Ningxia, China.
Hai-Yan
HY
Jiao
Breast neoplasms; Single nucleotide polymorphisms; Type 2 fibroblast growth factor receptor