Local and systemic tissue response submitted to injection of 2 and 30% polymethylmethacrylate in rats' tongue.
BACKGROUND
Adverse effects on the oral mucosa after the use of dermal fillers have been reported due to their increased use for facial aesthetics.


OBJECTIVE
This study aimed to evaluate, clinically and histologically, the local and systemic effects of two concentrations of polymethylmethacrylate (PMMA) dermal filler in rats.


METHODS
Fifty-four female rats were allocated into three treatment groups (2% PMMA, 30% PMMA and 0.9% NaCl), according to the substance injected in the tongue, and three experimental periods: 7, 60 and 90 days. The rats were clinically evaluated and then euthanised, and their tongue and right kidney removed. The histological sections were stained with haematoxylin/eosin and picrosirius.


RESULTS
Clinically, significant differences were found between test groups as to the occurrence of nodules (Kruskal-Wallis; p < 0.001). Histologically, there was greater inflammatory response in the PMMA compared with control (Kruskal-Wallis; p < 0.001). 30% PMMA had greater collagen formation (anova mixed models; p < 0.01). No migration of the material towards kidney was found.


CONCLUSIONS
Polymethylmethacrylate induced intense reaction in the initial period of observation (7 days), followed by gradual decrease during the study, favouring the presence of fibroplasia adjacent to the material.
Oral Medicine, School of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Karlon F
KF
Vargas
Oral Medicine, School of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Ruchielli L
RL
Borghetti
School of Dentistry, Brazilian Lutheran University, Porto Alegre, Rio Grande do Sul, Brazil.
Sabrina P
SP
Moure
Oral Medicine, School of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Karen
K
Cherubini
Oral Medicine, School of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Maria Antonia Z
MA
de Figueiredo
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000473:pathology; D003094:Collagen / Q000096:biosynthesis; D000067548:Dermal Fillers / Q000008:administration & dosage / Q000494:pharmacology; D037901:Euthanasia, Animal; D005260:Female; D005548:Foreign-Body Migration / Q000139:chemically induced / Q000473:pathology; D005549:Foreign-Body Reaction / Q000139:chemically induced / Q000473:pathology; D015726:Giant Cells / Q000187:drug effects / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced; D007271:Injections, Intradermal; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D009061:Mouth Mucosa / Q000187:drug effects; D019904:Polymethyl Methacrylate / Q000008:administration & dosage* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000008:administration & dosage / Q000494:pharmacology; D013997:Time Factors; D014059:Tongue / Q000187:drug effects* / Q000473:pathology*
D000067548:Dermal Fillers; D012965:Sodium Chloride; D003094:Collagen; D019904:Polymethyl Methacrylate
dermal filler; foreign body reaction; polymethylmethacrylate; rats