Left ventricular torsion changes post kidney transplantation.
BACKGROUND
To quantify changes of left ventricular (LV) torsion in patients' pre and post kidney transplantation.


METHODS
A prospective study was conducted on 48 patients who received kidney transplantation for end stage renal disease and without myocardial infarction. The rotation, twist and torsion of LV were studied pre and post kidney transplantation (6 months post transplantation) using velocity vector imaging by echocardiography. The data is expressed as mean ± standard deviation and compared by paired t-test at the p < 0.05 significance level.


RESULTS
Six months post kidney transplantation, left ventricular ejection fraction (from 40.33 ± 11.42 to 61.00 ± 13.68%), ratio of mitral early and late diastolic filling velocity (from 1.04 ± 0.57 to 1.21 ± 0.52), rotation of basal LV (from 4.48 ± 2.66 to 5.65 ± 2.64 degree), rotation of apical LV (from 4.27 ± 3.08 to 5.50 ± 4.25 degree), LV twist (8.75 ± 4.45 to 11.14 ± 5.25 degree) and torsion (from 1.06 ± 0.54 to 1.33 ± 0.61 degree/cm) were increased significantly (p < 0.05). Interventricular septum thickness (from 11.67 ± 2.39 to 9.67 ± 0.48 mm), left ventricular mass index (from 104.00 ± 16.47 to 95.50 ± 21.44 g/m(2)), systolic blood pressure (from 143.50 ± 34.99 to 121.50 ± 7.09 mmHg), serum blood urea nitrogen (from 42.40 ± 7.98 to 30.43 ± 13.85 mg/dL) and creatinine (from 4.53 ± 1.96 to 2.73 ± 2.57 mg/dL) were decreased significantly (p < 0.05).


CONCLUSIONS
Kidney transplantation in end stage renal disease without myocardial infarction results in improvement in left ventricular structure, function and myocardial mechanics as detected by echocardiography and velocity vector imaging. Velocity vector imaging provided valuable information for detection and follow-up of cardiac abnormalities in patients with end stage renal disease.
Department of Cardiovascular Ultrasound and Non-invasive Cardiology, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Sichuan, China.
Yan
Y
Deng
Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Anil
A
Pandit
Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Raymond L
RL
Heilman
Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Harini A
HA
Chakkera
Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Marek J
MJ
Mazur
Department of Internal Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Farouk
F
Mookadam
Cardiac mechanics; Echocardiography; Kidney transplant