Clinical aspects of hyperthyroidism, hypothyroidism, and thyroid screening in pregnancy.
OBJECTIVE
To evaluate the peer-reviewed literature on hypothyroidism, hyperthyroidism, and thyroid autoimmunity in pregnancy.


METHODS
We review published studies on thyroid autoimmunity and dysfunction in pregnancy, the impact of thyroid disease on pregnancy, and discuss implications for screening.


RESULTS
Overt hyperthyroidism and hypothyroidism are responsible for adverse obstetric and neonatal events. Several studies of association suggest that either subclinical hypothyroidism or thyroid autoimmunity increase the risk of complications. One randomized controlled trial showed that pregnant women with subclinical hypothyroidism benefit from treatment in terms of obstetric and neonatal complications, whereas another study demonstrated no benefit in the intelligence quotient of babies born to women with subclinical hypothyroidism. Thyroid autoimmunity has been associated with increased rate of pregnancy loss, recurrent miscarriage, and preterm delivery.


CONCLUSIONS
Current guidelines agree that overt hyperthyroidism and hypothyroidism need to be promptly treated and that as potential benefits outweigh potential harm, subclinical hypothyroidism also requires substitutive treatment. The chance that women with thyroid autoimmunity may benefit from levothyroxine treatment to improve obstetric outcome is intriguing, but adequately powered randomized controlled trials are needed. The issue of universal thyroid screening at the beginning of pregnancy is still a matter of debate, and aggressive case-finding is supported.
Division of Endocrinology, "V. Fazzi" Hospital, Lecce, Italy.
Roberto
R
Negro
Rockford Regional Dean, College of Medicine, University of Illinois, Rockford, Illinois.
Alex
A
Stagnaro-Green
D015551:Autoimmunity; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis*; D007037:Hypothyroidism / Q000175:diagnosis*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D013961:Thyroid Gland / Q000276:immunology*