The protective effects of the combination of sodium ferulate and oxymatrine on ethanol-induced liver damage in mice.
The aim of this study was to investigate the effects of the combination of SF and OMT on ethanol-induced liver damage in mice. The animal liver wet/dry weight (W/D) ratio and liver tissue histopathology, alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), malondialdehyde (MDA), superoxidase dismutase (SOD), C-reactive protein (CRP), interleukin-6 (IL-6), and nuclear factor κB (NF-κB) levels were measured. The data indicated that the levels of ALT, AST, TG, CRP, IL-6, NF-κB and MDA significantly decreased and that SOD activity improved after treatment with the combination of SF and OMT; the same effects were not observed with the same dose of SF or OMT when used alone. These results indicated that the combination of SF and OMT had a protective effect on ethanol-induced liver damage in mice and that antioxidation and anti-inflammatory effects might be involved in this protective mechanism.
School of Pharmacy, Yantai University, No. 30, Qingquan Road, Laishan District, Yantai, Shandong, China.
Xiaokun
X
Pei
School of Pharmacy, Yantai University, No. 30, Qingquan Road, Laishan District, Yantai, Shandong, China.
Wei
W
Wang
School of Pharmacy, Yantai University, No. 30, Qingquan Road, Laishan District, Yantai, Shandong, China.
Ningshu
N
Miao
School of Pharmacy, Yantai University, No. 30, Qingquan Road, Laishan District, Yantai, Shandong, China.
Mengxin
M
Xu
School of Pharmacy, Yantai University, No. 30, Qingquan Road, Laishan District, Yantai, Shandong, China.
Chunlei
C
Zhang
School of Pharmacy, Yantai University, No. 30, Qingquan Road, Laishan District, Yantai, Shandong, China.
Mengmeng
M
Sun
Beijing SL Pharmaceutical Co. Ltd, No. 9, Shijingshan Industrial Area, Haidian District, Beijing, China.
Mingbo
M
Xu
School of Pharmacy, Yantai University, No. 30, Qingquan Road, Laishan District, Yantai, Shandong, China. Electronic address: liuzhifengytu@163.com.
Zhifeng
Z
Liu
D000410:Alanine Transaminase / Q000097:blood; D000470:Alkaloids / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D003373:Coumaric Acids / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000633:toxicity*; D015850:Interleukin-6 / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011807:Quinolizines / Q000494:pharmacology / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000378:metabolism; D000093842:Matrines
D000410:Alanine Transaminase; D000470:Alkaloids; D001219:Aspartate Aminotransferases; D002097:C-Reactive Protein; D003373:Coumaric Acids; D000431:Ethanol; D015850:Interleukin-6; D008315:Malondialdehyde; D016328:NF-kappa B; D020011:Protective Agents; D011807:Quinolizines; D013482:Superoxide Dismutase; C037573:oxymatrine; D000093842:Matrines; C004999:ferulic acid
Anti-inflammatory; Antioxidant; Ethanol; Oxymatrine; Sodium ferulate