Rh(III)-catalyzed intramolecular redox-neutral cyclization of alkenes via C-H activation.
Biologically interesting fused oligocyclic lactams have been prepared via an intramolecular redox-neutral cyclization process. By the proper choice of the substrates with a wide variety of tethered olefins, the less favored C-H bond can be activated and functionalized. This C-H activation proceeds under mild conditions, obviates the need for external oxidants, and displays a broad scope with respect to the substituents.
Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany. glorius@uni-muenster.de.
Zhuangzhi
Z
Shi
Mélissa
M
Boultadakis-Arapinis
Dennis C
DC
Koester
Frank
F
Glorius
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007769:Lactams / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
D000475:Alkenes; D007769:Lactams; D012238:Rhodium