Genotype circulation pattern of human respiratory syncytial virus in Iran.
In order to have information on the molecular epidemiology and genetic circulation pattern of human respiratory syncytial virus (HRSV) in Iran, we studied the genetic variability of both group A and B HRSV strains during seven consecutive years by sequencing the hypervariable C-terminal domain of G protein. A total of 485 children <2years of age who were negative for influenza viruses, screened for the presence of HRSV in this research. HRSV was detected in 94 (19.38%) of the samples using nested RT-PCR. Group A viruses were isolated during each year, while group B viruses were isolated during 2009 and 2013. Phylogenetic analysis showed that all HRSV group A viruses belonged to three genotypes: GA1, GA2, GA5 and the group B viruses were in BA genotype.
Virology Department, School of Public Health, Tehran University of Medical Sciences, Iran. Electronic address: faghihloo@razi.tums.ac.ir.
Ebrahim
E
Faghihloo
Virology Department, School of Public Health, Tehran University of Medical Sciences, Iran. Electronic address: yavarian@tums.ac.ir.
Jila
J
Yavarian
Virology Department, School of Public Health, Tehran University of Medical Sciences, Iran. Electronic address: nz-shafiei@tums.ac.ir.
Nazanin Zahra Shafiei
NZ
Jandaghi
Virology Department, School of Public Health, Tehran University of Medical Sciences, Iran. Electronic address: ariaadonis@yahoo.com.
Azadeh
A
Shadab
Virology Department, School of Public Health, Tehran University of Medical Sciences, Iran. Electronic address: mokhtari@tums.ac.ir.
Talat Mokhtari
TM
Azad
D005838:Genotype; D006801:Humans; D007492:Iran / Q000453:epidemiology; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000821:virology*; D018113:Respiratory Syncytial Virus, Human / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
D012367:RNA, Viral
Genotype circulation; HRSV; Iran