Heterocycles 33: lipophilicity of a new class of thioethers estimated by reversed-phase thin-layer chromatography and different computational methods.
The retention behavior for a series of new polyheterocyclic compounds containing azolic rings (1,3-thiazole, 1,2,4-triazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole) has been investigated using reversed-phase thin-layer chromatography. Different approaches and computational methods were employed to evaluate their lipophilicity indices derived from chromatographic parameters. The obtained experimental results were correlated with various lipophilicity indices estimated via different computer software and internet websites. A strong correlation between experimental and computed results was observed. Furthermore, the lipophilicity parameters obtained by applying principal component analysis divided the investigated compounds into four groups according to their structural similarities.
Department of Organic Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Victor Babeş 41, Ro-400012 Cluj-Napoca, Romania.
Alexandra
A
Toma
Department of Organic Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Victor Babeş 41, Ro-400012 Cluj-Napoca, Romania hapau.denisa@umfcluj.ro.
Denisa
D
Hapău
Department of Analytical Chemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University of Cluj-Napoca, Arany János 11, Ro-400028 Cluj-Napoca, Romania.
Dorina
D
Casoni
Department of Organic Chemistry, Iuliu Haţieganu University of Medicine and Pharmacy, Victor Babeş 41, Ro-400012 Cluj-Napoca, Romania.
Valentin
V
Zaharia
D001393:Azoles / Q000737:chemistry; D056148:Chromatography, Reverse-Phase / Q000379:methods*; D002855:Chromatography, Thin Layer / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D025341:Principal Component Analysis; D013440:Sulfides / Q000737:chemistry*
D001393:Azoles; D013440:Sulfides