Serum 25 hydroxy vitamin D insufficiency associated with bronchial asthma in Lucknow, India.
OBJECTIVE
To assess the association between serum 25 hydroxy vitamin D levels and asthma and its control in Indian children.


METHODS
This was a prospective case-control study conducted in tertiary care hospital. Cases of asthma and healthy age-matched controls were included, aged 1-15 y, who had not received any vitamin D supplementation in the last year and had no other co-morbidity, after obtaining written informed parental consent. 25 hydroxy vitamin D insufficiency was taken below level of ≤ 30 ng/mL.


RESULTS
Fifty asthmatics and 25 age-matched controls were recruited from August 2011-July 2012. 25 hydroxy vitamin D insufficiency was associated with occurrence of asthma (OR = 13.5; 95 % CI = 4.25-42.85: p = 0.000). With decreasing level of asthma control there was increasing strength of association with 25 hydroxy vitamin D insufficiency [χ (2) for trend = 24.96 (p = 0.000)].


CONCLUSIONS
25 hydroxy vitamin D insufficiency is associated with bronchial asthma as well as its level of control.
Department of Pediatrics and Translational Medicine Unit, King George's Medical University, Lucknow, 226003, India, shallya@rediffmail.com.
Shally
S
Awasthi
Kumar
K
Vikram
D000293:Adolescent; D001249:Asthma / Q000097:blood* / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D008297:Male; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood* / Q000150:complications*
D014807:Vitamin D; C104450:25-hydroxyvitamin D