Intraprocedural yttrium-90 positron emission tomography/CT for treatment optimization of yttrium-90 radioembolization.
Radioembolization with yttrium-90 ((90)Y) microspheres relies on delivery of appropriate treatment activity to ensure patient safety and optimize treatment efficacy. We report a case in which (90)Y positron emission tomography (PET)/computed tomography (CT) was performed to optimize treatment planning during a same-day, three-part treatment session. This treatment consisted of (i) an initial (90)Y infusion with a dosage determined using an empiric treatment planning model, (ii) quantitative (90)Y PET/CT imaging, and (iii) a secondary infusion with treatment planning based on quantitative imaging data with the goal of delivering a specific total tumor absorbed dose.
Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920.
Austin C
AC
Bourgeois
Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920.
Ted T
TT
Chang
Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920.
Yong C
YC
Bradley
Molecular Imaging and Translational Research Program, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920.
Shelley N
SN
Acuff
Department of Radiology, University of Tennessee Graduate School of Medicine, Knoxville, TN 37920; Department of Radiology, University of Tennessee Medical Center, 1924 Alcoa Highway, Knoxville, TN 37920. Electronic address: apasciak@utmck.edu.
Alexander S
AS
Pasciak
D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D015641:Radiography, Interventional; D019275:Radiopharmaceuticals / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000008:administration & dosage*
D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes
(18)FDG; (90)Y; (99m)Tc MAA; BSA; HCC; T/N; TTR; body surface area; fluorine 18–labeled deoxyglucose; hepatocellular carcinoma; technetium-99m macroaggregated albumin; tumor-to-normal uptake; tumoricidal target ratio; yttrium-90