Redox reactivity of cerium oxide nanoparticles against dopamine.
The interaction between dopamine and the redox active cerium oxide nanoparticles, or nanoceria was studied using a suite of spectroscopic and surface characterization methods. Changes in the chemical reactivity and concentration of dopamine upon exposure to nanoceria was assessed in aqueous solutions and a human physiological fluid--human serum. The results indicate strong attachment of dopamine to the nanoparticle surface through oxidation followed by chemisorption of the oxidative product with formation of a charge transfer complex. Such oxidation/surface adsorption processes between nanoceria and dopamine lead to a reduction of the concentration of free dopamine in aqueous environments. These findings suggest that the redox reactivity of nanoceria may alter dopamine levels in biological systems exposed to these particles and indicate the need for a comprehensive assessment of the potential neurological consequences that might result from intended or unintended exposure to these particles.
Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.
Akhtar
A
Hayat
Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.
Daniel
D
Andreescu
Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA.
Gonca
G
Bulbul
Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY, USA. Electronic address: eandrees@clarkson.edu.
Silvana
S
Andreescu
D000327:Adsorption; D000975:Antioxidants / Q000378:metabolism*; D002563:Cerium / Q000097:blood*; D004298:Dopamine / Q000097:blood*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D052638:Particulate Matter / Q000097:blood*; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared; D055672:Static Electricity; D013535:Suspensions / Q000737:chemistry; D014867:Water
D000975:Antioxidants; D052638:Particulate Matter; D013535:Suspensions; D014867:Water; D002563:Cerium; C030583:ceric oxide; D004298:Dopamine
Dopamine; Nanoceria; Redox reactivity of nanoparticles; Surface attachment; Surface oxidation