Synthetic Routes to a Series of Proximal and Distal 2'-Deoxy Fleximers.
Two series of innovative 2'-deoxy nucleoside analogues have been designed where the nucleobase has been split into its imidazole and pyrimidine subunits. This structural modification serves to introduce flexibility into the nucleobase scaffold while still retaining the elements required for recognition. The synthetic efforts to realize these analogues are described within.
Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA Fax +1(410)4552608.
Orrette R
OR
Wauchope
Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA Fax +1(410)4552608.
Melvin
M
Velasquez
Department of Chemistry and Biochemistry, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD, 21250, USA Fax +1(410)4552608.
Katherine
K
Seley-Radtke
adenosine; flexible nucleosides; fleximers; guanosine; nucleobase; resistance