IDENTIFICATION OF MYOCARDIAL INFARCTION USING THREE-DIMENSIONAL STRAIN TENSOR FRACTIONAL ANISOTROPY.
Accurate localization of myocardial viability is important in diagnosis of infarction. Regional strain function provides excessive information for clinical decision making but comparison of strain tensor profiles across differing tissue types is usually difficult due to multivariate nature of tensors. It is desirable to describe tensors with simplified scalar indices which are more mathematically and statistically intuitive. In this work, anisotropy of tensors in healthy and experimental infarct regions in a large animal model is assessed and compared to directional components of strain tensors which are currently the most popular indices in active use. Myocardial strain tensors are computed using zHARP, a magnetic resonance (MR) tagging technique that provides quantification of cardiac function with direct computation of three-dimensional tensors from two-dimensional short axis MR images. Fractional anisotropy of strain tensors shows high correlation with late gadolinium enhanced images and is capable of discrimination between healthy and infarcted regions.
Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, M.D., USA.
Sahar
S
Soleimanifard
Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, M.D., USA.
Khaled Z
KZ
Abd-Elmoniem
Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, M.D., USA.
Harsh K
HK
Agarwal
Department of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, M.D., USA.
Miguel S
MS
Tomas
Department of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, M.D., USA.
Tetsuo
T
Sasano
Department of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, M.D., USA.
Evertjan
E
Vonken
Department of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, M.D., USA.
Amr
A
Youssef
Department of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, M.D., USA.
M Roselle
MR
Abraham
Department of Cardiology, School of Medicine, Johns Hopkins University, Baltimore, M.D., USA.
Theodore P
TP
Abraham
Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, M.D., USA.
Jerry L
JL
Prince
Fractional Anisotropy; HARP; Infarction; Strain tensor; zHARP