[Inv(16)-type acute myeloid leukemia with repeated skin infiltration without bone marrow relapse before and after allogeneic hematopoietic stem cell transplantation].
We report a 40-year-old woman diagnosed as having acute myeloid leukemia with CBFB-MYH11. Before and after stem cell transplantation in the phase of molecular remission of the marrow, CBFB-MYH11-positive cells were detected by RT-PCR analysis in skin lesions. The former was pathologically diagnosed as leukemic infiltration, while the latter was considered to be graft-versus-host disease. We can speculate that a low level of leukemic stem cells not detectable by RT-PCR analysis remained in the bone marrow, at least prior to transplantation. This case may suggest interesting biological features of inv(16)-type acute myeloid leukemia.
Department of Hematology and Oncology, Dokkyo Medical University School of Medicine.
Katsuya
K
Tokita
Wataru
W
Takahashi
Honoka
H
Arai
Tomoyuki
T
Handa
Yuko
Y
Nakamura
Kazuhiro
K
Maki
Ko
K
Sasaki
Kinuko
K
Mitani
D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006086:Graft vs Host Disease / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D015514:Oncogene Proteins, Fusion / Q000378:metabolism; D012008:Recurrence; D012867:Skin / Q000473:pathology*
D015514:Oncogene Proteins, Fusion; C471254:inv(16) fusion protein, human