Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism.
Adolescents with a family history of alcoholism (FHP) are at heightened risk for developing alcohol use disorders (AUDs). The nucleus accumbens (NAcc), a key brain region for reward processing, is implicated in the development of AUDs. Thus, functional connectivity of the NAcc may be an important marker of risk in FHP youth. Resting state functional magnetic resonance imaging (rs-fcMRI) was used to examine the intrinsic connectivity of the NAcc in 47 FHP and 50 family history negative (FHN) youth, ages 10-16 years old. FHP and FHN adolescents showed significant group differences in resting state synchrony between the left NAcc and bilateral inferior frontal gyri and the left postcentral gyrus (PG). Additionally, FHP youth differed from FHN youth in right NAcc functional connectivity with the left orbitofrontal cortex (OFC), left superior temporal gyrus, right cerebellum, left PG, and right occipital cortex. These results indicate that FHP youth have less segregation between the NAcc and executive functioning brain regions, and less integration with reward-related brain areas, such as the OFC. The findings of the current study highlight that premorbid atypical connectivity of appetitive systems, in the absence of heavy alcohol use, may be a risk marker in FHP adolescents.
Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, DC7P, Portland, OR, USA.
Anita
A
Cservenka
Graduate Program of Neurobiology and Behavior, University of Washington, Seattle, WA, USA.
Kaitlyn
K
Casimo
Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, DC7P, Portland, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L470, Portland, OR, USA; Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, USA.
Damien A
DA
Fair
Department of Psychiatry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, DC7P, Portland, OR, USA; Department of Behavioral Neuroscience, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L470, Portland, OR, USA. Electronic address: nagelb@ohsu.edu.
Bonnie J
BJ
Nagel
D000293:Adolescent; D019973:Alcohol-Related Disorders / Q000503:physiopathology; D000437:Alcoholism / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D002531:Cerebellum / Q000503:physiopathology; D002648:Child; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D009714:Nucleus Accumbens / Q000503:physiopathology*; D010296:Parietal Lobe / Q000503:physiopathology; D012107:Research Design; D012201:Reward
Adolescence; Alcohol; Familial; Risk; Ventral striatum