Highly Potent, Chemically Stable Quorum Sensing Agonists forVibrio Cholerae.
In theVibrio choleraepathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist ofV. choleraequorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence inV. cholerae.
Department of Chemistry, Princeton University, Washington Road, Princeton, NJ 08544 (USA).
Lark J
LJ
Perez
Department of Chemistry, Princeton University, Washington Road, Princeton, NJ 08544 (USA).
Theodora K
TK
Karagounis
Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544 (USA).
Amanda
A
Hurley
Department of Molecular Biology, Princeton University, Washington Road, Princeton, NJ 08544 (USA) ; Howard Hughes Medical Institute Chevy Chase, MD 02815.
Bonnie L
BL
Bassler
Department of Chemistry, Princeton University, Washington Road, Princeton, NJ 08544 (USA).
Martin F
MF
Semmelhack