Genetic variations in insulin-like growth factor binding protein acid labile subunit gene associated with growth traits in beef cattle (Bos taurus) in China.
The insulin-like growth factor binding protein acid labile subunit (IGFALS) gene encodes a serum protein that binds to IGFs and regulates growth, development, and other physiological processes. We have found that sequencing of the IGFALS gene in Chinese Qinchuan beef cattle (n=300) revealed four SNP loci in exon two of the gene (g1219: T>C, g1893: T>C, g2612: G>A, and g2696: A>G). The SNP g2696: A>G resulted in a change from asparagine to aspartic acid (p. N574D) in the leucine-rich repeat region in the carboxyl-terminal domain of IGFALS. Four SNPs were in low linkage disequilibrium, and 12 different haplotypes were identified in the population. Association analysis suggested that SNP g1219: T>C had a significant association with hip width (P<0.05) and SNP g2696: A>G displayed a significant association with stature (P<0.05). The results from our investigation indicated that polymorphisms in the IGFALS gene were associated with growth traits of bovine, and may serve as a genetic marker for selection of beef cattle for growth traits, including stature.
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Yu
Y
Liu
HeBei North University, Zhang Jiakou, Hebei 075000, China.
Xiaoyan
X
Duan
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Xiaolin
X
Liu
College of Animal Science and Technology, Sichuan Agricultural University, Yaan, Sichuan 625014, China.
Jiazhong
J
Guo
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Hongliang
H
Wang
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Zhixiong
Z
Li
College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China.
Jing
J
Yang
D000818:Animals; D001483:Base Sequence; D049628:Body Size / Q000235:genetics; D001835:Body Weight / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics*; D002417:Cattle / Q000235:genetics* / Q000254:growth & development; D002681:China; D005787:Gene Frequency; D056726:Genetic Association Studies; D006023:Glycoproteins / Q000235:genetics*; D006239:Haplotypes; D015810:Linkage Disequilibrium; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
D002352:Carrier Proteins; D006023:Glycoproteins; C075944:insulin-like growth factor binding protein, acid labile subunit
Association; Bovine; Growth traits; IGFALS; SNP