Artocarpus heterophyllus L. seed starch-blended gellan gum mucoadhesive beads of metformin HCl.
Jackfruit (Artocarpus heterophyllus Lam., family: Moraceae) seed starch (JFSS)-gellan gum (GG) mucoadhesive beads containing metformin HCl were developed through ionotropic gelation technique. The effect of GG to JFSS ratio and CaCl2 concentration on the drug encapsulation efficiency (DEE, %) and cumulative drug release at 10h (R10h, %) was optimized and analyzed using response surface methodology based on 3(2) factorial design. The optimized JFSS-GG beads containing metformin HCl showed DEE of 92.67±4.46%, R10h of 61.30±2.37%, and mean diameter of 1.67±0.27 mm. The optimized beads showed pH-dependent swelling and mucoadhesivity with the goat intestinal mucosa. The in vitro drug release from all these JFSS-GG beads containing metformin HCl was followed zero-order pattern (R(2)=0.9907-0.9975) with super case-II transport mechanism over a period of 10 h. The beads were also characterized by SEM and FTIR. The optimized JFSS-GG beads containing metformin HCl exhibited significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.
Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757 086, Odisha, India. Electronic address: amitkrnayak@yahoo.co.in.
Amit Kumar
AK
Nayak
Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur 495009, Chhattisgarh, India.
Dilipkumar
D
Pal
Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757 086, Odisha, India.
Kousik
K
Santra
D000269:Adhesives / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D031622:Artocarpus / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D008687:Metformin / Q000737:chemistry* / Q000494:pharmacology; D008863:Microspheres; D011135:Polysaccharides, Bacterial / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry*; D013213:Starch / Q000737:chemistry*; D013499:Surface Properties
D000269:Adhesives; D004337:Drug Carriers; D011135:Polysaccharides, Bacterial; C048288:gellan gum; D013213:Starch; D008687:Metformin
Drug release; Jackfruit seed starch; Mucoadhesion