Diagnostic performance of the QuantiFERON-TB Gold In-Tube assay and factors associated with nonpositive results in patients with miliary tuberculosis.
The QuantiFERON-TB Gold In-Tube (QFT-GIT) assay provides suboptimal diagnostic performance in patients with miliary tuberculosis. QFT-GIT results should be carefully interpreted, particularly in patients suspected of having miliary tuberculosis with severe lymphocytopenia or an extent of ground glass opacity (GGO) >50% on chest computed tomography (CT). Diagnostic performance of the QFT-GIT assay was evaluated in 44 patients with miliary tuberculosis. Among these individuals, 30 (68%) had true-positive QFT-GIT results. Severe lymphocytopenia and an extent of GGO >50% on chest CT were independent risk factors for nonpositive QFT-GIT results.
Department of Internal Medicine.
Chang Ho
CH
Kim
Jae Kwang
JK
Lim
Seung Soo
SS
Yoo
Shin Yup
SY
Lee
Seung Ick
SI
Cha
Jae Yong
JY
Park
Jaehee
J
Lee
D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D059425:Interferon-gamma Release Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014391:Tuberculosis, Miliary / Q000175:diagnosis*
QuantiFERON-TB Gold In-Tube assay; interferon-gamma release assay; miliary tuberculosis