Nrf1 to the rescue.
When the level of proteasomal activity in a cell drops off, a transcription factor called Nrf1 travels to the nucleus to activate the genes that code for proteasomes.
Jin Ye is in the Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, United States jin.ye@utsouthwestern.edu.
Jin
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Ye
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D006801:Humans; D051266:Nuclear Respiratory Factor 1 / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects*; D061988:Proteasome Inhibitors / Q000494:pharmacology*
D018797:Cell Cycle Proteins; D051266:Nuclear Respiratory Factor 1; D061988:Proteasome Inhibitors; D046988:Proteasome Endopeptidase Complex; D000251:Adenosine Triphosphatases
Nrf1; p97; proteasomes