Limonene inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal function and dopamine release.
Methamphetamine is a psychomotor stimulant that produces hyperlocomotion in rodents. Limonene (a cyclic terpene from citrus essential oils) has been reported to induce sedative effects. In this study, we demonstrated that limonene administration significantly inhibited serotonin (5-hydroxytryptamine, 5-HT)-induced head twitch response in mice. In rats, pretreatment with limonene decreased hyperlocomotion induced by methamphetamine injection. In addition, limonene reversed the increase in dopamine levels in the nucleus accumbens of rats given methamphetamine. These results suggest that limonene may inhibit stimulant-induced behavioral changes via regulating dopamine levels and 5-HT receptor function.
Pharmaceutical Standardization Research and Testing Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Republic of Korea. Electronic address: actpotyjs@korea.kr.
Jaesuk
J
Yun
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D002957:Citrus / Q000737:chemistry*; D053138:Cyclohexenes / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D000077222:Limonene; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D009822:Oils, Volatile / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000378:metabolism*; D059326:Serotonergic Neurons / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism*; D013729:Terpenes / Q000494:pharmacology*
D000697:Central Nervous System Stimulants; D053138:Cyclohexenes; D009822:Oils, Volatile; D010936:Plant Extracts; D011985:Receptors, Serotonin; D013729:Terpenes; D012701:Serotonin; D008694:Methamphetamine; D000077222:Limonene; D004298:Dopamine
5-HT; Dopamine; Drug addiction; Limonene; Methamphetamine