Granulocyte colony-stimulating factor-producing lung cancer and acute respiratory distress syndrome.
Granulocyte colony-stimulating factor (G-CSF)-producing lung cancers are known to cause extreme leukocytosis. However, acute respiratory distress syndrome (ARDS) caused by G-CSF-producing lung cancer is extremely rare. We present a case of G-CSF-producing lung cancer with marked leukocytosis, which rapidly led to severe ARDS after the patient developed pneumonia. The present case suggests that extreme leukocytosis may easily lead to ARDS, triggered by infection. Thus, G-CSF-producing lung cancer with marked leukocytosis should be carefully monitored before surgery and during treatment.
Department of Emergency and Critical Care Medicine, Shirane Tokushukai Hospital, Minami-Alps, Yamanashi, Japan; Department of Emergency and Critical Care Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Ryota
R
Inokuchi
Haruki
H
Manabe
Fumihito
F
Ohta
Kensuke
K
Nakamura
Susumu
S
Nakajima
Naoki
N
Yahagi
D002277:Carcinoma / Q000175:diagnosis / Q000209:etiology*; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology*; D006801:Humans; D007964:Leukocytosis / Q000175:diagnosis / Q000209:etiology*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000209:etiology*
D016179:Granulocyte Colony-Stimulating Factor
ARDS; G-CSF; large-cell carcinoma; leukocytosis; lung cancer