Cardiovascular health in adolescents with type 1 diabetes: the SEARCH CVD study.
OBJECTIVE
In their Strategic Impact Goal Statement, the American Heart Association focused on primordial prevention of cardiovascular risk factors by defining metrics for ideal cardiovascular health (ICH). The prevalence of ICH among youth with type 1 diabetes is unknown. Youth with type 1 diabetes face an increased risk of cardiovascular disease (CVD) as they age. The purpose of this report was to examine the prevalence of ICH in a population of youth with type 1 diabetes and to examine the association of ICH with measures of cardiovascular structure and function.


METHODS
This report is based on SEARCH CVD an ancillary study to the SEARCH for Diabetes in Youth. A total of 190 adolescents with type 1 diabetes had complete data on all of the ICH metrics at baseline and had measures of arterial stiffness [pulse wave velocity (PWV), brachial distensibility (BrachD), and augmentation index (AIx)] and carotid intima-media thickness completed at a follow-up visit [on average 5 yr after baseline (interquartile range 4-5)].


RESULTS
No subjects met the ICH criteria for all 7 metrics. Meeting an increasing number of ICH metrics was significantly associated with lower arterial stiffness [lower PWV of the trunk (β = -0.02 ±0.01; p = 0.004) and AIx (β = -2.2 ±0.66; p = 0.001), and increased BrachD (β = 0.14 ±0.07; p = 0.04)].


CONCLUSIONS
Increasing number of ICH metrics was significantly associated with decreased arterial stiffness, but prevalence of ICH in this population was low. Youth with type 1 diabetes could benefit from improvements in their cardiovascular health.
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, 33612, USA.
Amy C
AC
Alman
Jennifer W
JW
Talton
R Paul
RP
Wadwa
Elaine M
EM
Urbina
Lawrence M
LM
Dolan
Stephen R
SR
Daniels
Richard F
RF
Hamman
Ralph B
RB
D'Agostino
Santica M
SM
Marcovina
Elizabeth J
EJ
Mayer-Davis
Dana M
DM
Dabelea
D000293:Adolescent; D000294:Adolescent Behavior; D000572:American Heart Association; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D003120:Colorado / Q000453:epidemiology; D003131:Combined Modality Therapy; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000628:therapy*; D003925:Diabetic Angiopathies / Q000453:epidemiology / Q000517:prevention & control*; D058065:Diabetic Cardiomyopathies / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006293:Health Promotion; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology / Q000517:prevention & control; D008137:Longitudinal Studies; D008297:Male; D009043:Motor Activity; D018673:Nutrition Policy; D009820:Ohio / Q000453:epidemiology; D010349:Patient Compliance; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
adolescent; carotid intima-media thickness; diabetes mellitus, type 1; pulse wave analysis