Compounds fromSimarouba berteroanawhich inhibit proliferation ofNF1-defective cancer cells.
A neurofibromatosis type 1 (NF1) based bioassay-guided phytochemical investigation onSimarouba berteroanaled to the isolation of one new canthin-6-one-9-methoxy-5-O-β-D-glucopyranoside (1), seven known canthine alkaloids (2-8), two known quassinoids (9-10) and a known neo-lignan (11). The structures of all compounds were established by HRMS, 1D- and 2D-NMR analysis and comparison with previously reported data. Most of the compounds inhibited the proliferation of anNf1- andp53-deficient mouse glioma cell line at non-cytotoxic concentrations.
Molecular Targets Laboratory, Center for Cancer Research, Frederick, Maryland 21702, United States.
Krishna P
KP
Devkota
Molecular Targets Laboratory, Center for Cancer Research, Frederick, Maryland 21702, United States.
Jennifer A
JA
Wilson
Molecular Targets Laboratory, Center for Cancer Research, Frederick, Maryland 21702, United States ; SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, Maryland 21702, United States.
Curtis J
CJ
Henrich
Molecular Targets Laboratory, Center for Cancer Research, Frederick, Maryland 21702, United States.
James B
JB
McMahon
Mouse Cancer Genetics Program, Center for Cancer Research, Frederick, Maryland 21702, United States.
Karlyne M
KM
Reilly
Molecular Targets Laboratory, Center for Cancer Research, Frederick, Maryland 21702, United States.
John A
JA
Beutler
Neurofibromatosis type 1; Simarouba berteroana; canthine alkaloids; glioblastomas; growth inhibition