Effect of acute moderate exercise on induced inflammation and arterial function in older adults.
Acute inflammation reduces flow-mediated vasodilatation and increases arterial stiffness in young healthy individuals. However, this response has not been studied in older adults. The aim of this study, therefore, was to evaluate the effect of acute induced systemic inflammation on endothelial function and wave reflection in older adults. Furthermore, an acute bout of moderate-intensity aerobic exercise can be anti-inflammatory. Taken together, we tested the hypothesis that acute moderate-intensity endurance exercise, immediately preceding induced inflammation, would be protective against the negative effects of acute systemic inflammation on vascular function. Fifty-nine healthy volunteers between 55 and 75 years of age were randomized to an exercise or a control group. Both groups received a vaccine (induced inflammation) and sham (saline) injection in a counterbalanced crossover design. Inflammatory markers, endothelial function (flow-mediated vasodilatation) and measures of wave reflection and arterial stiffness were evaluated at baseline and at 24 and 48 h after injections. There were no significant differences in endothelial function and arterial stiffness between the exercise and control group after induced inflammation. The groups were then analysed together, and we found significant differences in the inflammatory markers 24 and 48 h after induction of acute inflammation compared with sham injection. However, flow-mediated vasodilatation, augmentation index normalized for heart rate (AIx75) and β-stiffness did not change significantly. Our results suggest that acute inflammation induced by influenza vaccination did not affect endothelial function in older adults.
* Department of Anesthesiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. ranadive.sushant@mayo.edu.
Sushant Mohan
SM
Ranadive
Rebecca Marie
RM
Kappus
Marc D
MD
Cook
Huimin
H
Yan
Abbi Danielle
AD
Lane
Jeffrey A
JA
Woods
Kenneth R
KR
Wilund
Gary
G
Iwamoto
Vishwas
V
Vanar
Rudhir
R
Tandon
Bo
B
Fernhall
D000367:Age Factors; D000368:Aged; D018592:Cross-Over Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D015444:Exercise; D005260:Female; D006339:Heart Rate; D006801:Humans; D007087:Illinois; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000097:blood; D007252:Influenza Vaccines / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D013997:Time Factors; D059289:Vascular Stiffness; D014664:Vasodilation
D018836:Inflammation Mediators; D007252:Influenza Vaccines