De-peptidising protein-protein interactions - big jobs for small molecules.
Virtually all biological processes rely on protein-protein interactions (PPIs) for signal propagation, therefore representing a vast array of potentially viable therapeutic intervention points. Targeting PPIs is a relatively novel drug development strategy so computational approaches towards analysing the interface between protein partners and predicting the likelihood of developing a small molecule inhibitor are still progressing. This review provides an overview of recent successful examples of computational methodologies used to predict druggable PPIs and small molecules designed to inhibit them.
Darren
D
Fayne
D015195:Drug Design; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D011485:Protein Binding; D025941:Protein Interaction Mapping; D054852:Small Molecule Libraries
D010455:Peptides; D054852:Small Molecule Libraries