T Cell Transcription Factors and Their Impact on HIV Expression.
By targeting CD4+effector T cells, HIV has a dramatic impact on the depletion, expansion and function of the different polarized T cell subsets. The maturation of T cell lineages is in part driven by intrinsic transcription factors that potentially influence how efficiently HIV replicates. In this review, we explore whether transcription factors that are required for polarizing T cells influence HIV replication. In particular, we examine provirus transcription as well as the establishment and maintenance of HIV latency. Furthermore, it is suggested these factors may provide novel cell-specific therapeutic strategies for targeting the HIV latent reservoir.
Graduate Program in Molecular and Translational Medicine, Boston University School of Medicine, Boston, MA.
Katarzyna
K
Kaczmarek
Section of Infectious Diseases and Department of Medicine, Boston University School of Medicine, Boston, MA.
Ayana
A
Morales
Graduate Program in Molecular and Translational Medicine, Boston University School of Medicine, Boston, MA. ; Section of Infectious Diseases and Department of Medicine, Boston University School of Medicine, Boston, MA.
Andrew J
AJ
Henderson
CD4+ T cells; HIV; latency; transcription