Quantitative assessment of oral mucosa and labial minor salivary glands in patients with Sjögren's syndrome using swept source OCT.
Three-dimensional imaging of the mucosa of the lower lip and labial minor salivary glands is demonstrated in vivo using swept source optical coherence tomography (OCT) system at 1310 nm with modified interface. Volumetric data sets of the inner surface of the lower lip covering ~230 mm(2) field are obtained from patients with Sjögren's syndrome and a control group. OCT enables high-resolution visualization of mucosal architecture using cross-sectional images as well as en-face projection images. Comprehensive morphometry of the labial minor salivary glands is performed, and statistical significance is assessed. Statistically significant differences in morphometric parameters are found when subgroups of patients with Sjögren's syndrome are analyzed.
Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, ul. Grudziadzka 5, 87-100 Toruń, Poland.
Ireneusz
I
Grulkowski
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznań, Poland.
Jan K
JK
Nowak
Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, ul. Grudziadzka 5, 87-100 Toruń, Poland.
Karol
K
Karnowski
Department of Rheumatology and Internal Diseases, Poznań University of Medical Sciences, ul. 28 Czerwca 1956 r. 135/147, 61-545 Poznań, Poland.
Paweł
P
Zebryk
Department of Rheumatology and Internal Diseases, Poznań University of Medical Sciences, ul. 28 Czerwca 1956 r. 135/147, 61-545 Poznań, Poland.
Mariusz
M
Puszczewicz
Department of Pediatric Gastroenterology and Metabolic Diseases, Poznań University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznań, Poland.
Jaroslaw
J
Walkowiak
Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University, ul. Grudziadzka 5, 87-100 Toruń, Poland.
Maciej
M
Wojtkowski
(110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging; (170.4580) Optical diagnostics for medicine; (170.6930) Tissue