Health resource utilization and cost associated with myeloproliferative neoplasms in a large United States health plan.
Myelofibrosis (MF), polycythemia vera (PV) and essential thrombocythemia (ET) may lead to bone marrow fibrosis. Because the disease course of ET and PV are long and the disease course of MF may be fatal, healthcare resource utilization (HRU) associated costs of these neoplasms are especially important to understand. We used a large US health insurance claim database to describe the costs of these diseases. Compared to age-gender matched comparisons without myeloproliferative neoplasms (MPN), all aspects of HRU that we examined, including inpatient, outpatient and emergency room visits and pharmacy, as well as overall healthcare expenditures, were significantly higher in patients with MF, PV and ET (e.g. MF total costs = $54 168 vs. $10 203; PV = $14 903 vs. $7913; ET = $29 553 vs. $8026) than in matched comparisons. In order to reduce the burden of illness associated with these diseases, continued efforts in the development of more efficacious treatments for these disorders are needed.
Oncology-Global Evidence and Value Development, Medical Affairs and Research and Development , Sanofi, Cambridge, MA , USA.
Jyotsna
J
Mehta
Hongwei
H
Wang
Jon P
JP
Fryzek
Sheikh Usman
SU
Iqbal
Ruben
R
Mesa
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015897:Comorbidity; D016208:Databases, Factual; D005260:Female; D017048:Health Care Costs; D006295:Health Resources; D006801:Humans; D007348:Insurance, Health; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000175:diagnosis / Q000453:epidemiology*; D010342:Patient Acceptance of Health Care; D012189:Retrospective Studies; D014481:United States / Q000453:epidemiology; D055815:Young Adult
Myeloproliferative disorders; health resource utilization