Immunohistochemical patterns in the interfollicular Caucasian scalps: influences of age, gender, and alopecia.
Skin ageing and gender influences on the scalp have been seldom studied. We revisited the changes in the interfollicular scalp. The study was performed on a population of 650 volunteers (300 women and 350 men) for over 7 years. Three age groups were selected in both genders, namely, subjects aged 20-35, 50-60, and 60-70 years. The hair status was further considered according to nonalopecic and alopecic patterns and severity (discrete, moderate, and severe). Biopsies from the parietal area were processed for immunohistochemistry. Stromal cells were distinguished according to the presence of vimentin, Factor XIIIa, CD117, and versican. Blood and lymphatic vessels were highlighted by Ulex europaeus agglutinin-1 and human podoplanin immunoreactivities, respectively. Actinic elastosis was identified by the lysozyme coating of elastic fibres. The epidermis was explored using the CD44 variant 3 and Ki67 immunolabellings. Biplot analyses were performed. Immunohistochemistry revealed a prominent gender effect in young adults. Both Factor XIIIa+ dermal dendrocytes and the microvasculature size decreased with scalp ageing. Alopecia changes mimicked stress-induced premature senescence.
Department of Dermatopathology, University Hospital of Liège, 4000 Liège, Belgium ; Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, University of Liège, 4000 Liège, Belgium.
Claudine
C
Piérard-Franchimont
L'Oréal, Research & Innovation, 93400 Saint-Ouen, France.
Geneviève
G
Loussouarn
L'Oréal, Research & Innovation, 93400 Saint-Ouen, France.
Ségolène
S
Panhard
DSL Consult, 75000 Paris, France.
Didier
D
Saint Léger
L'Oréal, Research & Innovation, 93400 Saint-Ouen, France.
Myriam
M
Mellul
Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, University of Liège, 4000 Liège, Belgium.
Gérald E
GE
Piérard
D000328:Adult; D000368:Aged; D000375:Aging / Q000235:genetics / Q000378:metabolism; D000505:Alopecia / Q000453:epidemiology / Q000473:pathology*; D001706:Biopsy; D004817:Epidermis / Q000473:pathology; D026122:Factor XIIIa / Q000096:biosynthesis / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019009:Proto-Oncogene Proteins c-kit / Q000096:biosynthesis / Q000378:metabolism; D012535:Scalp / Q000378:metabolism / Q000473:pathology*; D012727:Sex Characteristics; D015595:Skin Aging; D053675:Versicans / Q000096:biosynthesis / Q000378:metabolism; D014746:Vimentin / Q000096:biosynthesis / Q000378:metabolism; D044465:White People
D014746:Vimentin; D053675:Versicans; D026122:Factor XIIIa; D019009:Proto-Oncogene Proteins c-kit