Advances in the management of neurogenic detrusor overactivity in multiple sclerosis.
Bladder dysfunction in multiple sclerosis (MS) can be socially disabling, have negative psychological and economic consequences, and impair patients' quality of life. Knowledge of the functional anatomy and physiology of the urinary tract is essential to understand the symptoms associated with central nervous system lesions and the pharmacotherapies used to treat them. Treatments for neurogenic detrusor overactivity (NDO) have consisted mainly of administration of anticholinergic drugs, which have been shown to provide suboptimal clinical benefits and be poorly tolerated. The US Food and Drug Administration (FDA) approval of intravesicular botulinum toxin therapy provides a second-line option for MS patients with NDO not responsive to anticholinergic drugs. We performed a review of key literature pertaining to the intravesicular application of botulinum toxin. In the management of NDO, administration of intravesicular botulinum toxin using clean intermittent catheterization decreases the incidence of urinary tract infections, promotes urinary continence, and improves quality of life for 9 months after a single injection; moreover, those benefits are maintained with repeated injections over time.
Department of Neurology, University of Utah, Salt Lake City, UT, USA (GJY, ASF, JWR); Neurovirology Research Laboratory, SLC-VAMC, Department of Neurology, Salt Lake City, UT, USA (NGC, JWR); and The Brain Institute, University of Utah, Salt Lake City, UT, USA (JWR).
Gael J
GJ
Yonnet
Department of Neurology, University of Utah, Salt Lake City, UT, USA (GJY, ASF, JWR); Neurovirology Research Laboratory, SLC-VAMC, Department of Neurology, Salt Lake City, UT, USA (NGC, JWR); and The Brain Institute, University of Utah, Salt Lake City, UT, USA (JWR).
Anette S
AS
Fjeldstad
Department of Neurology, University of Utah, Salt Lake City, UT, USA (GJY, ASF, JWR); Neurovirology Research Laboratory, SLC-VAMC, Department of Neurology, Salt Lake City, UT, USA (NGC, JWR); and The Brain Institute, University of Utah, Salt Lake City, UT, USA (JWR).
Noel G
NG
Carlson
Department of Neurology, University of Utah, Salt Lake City, UT, USA (GJY, ASF, JWR); Neurovirology Research Laboratory, SLC-VAMC, Department of Neurology, Salt Lake City, UT, USA (NGC, JWR); and The Brain Institute, University of Utah, Salt Lake City, UT, USA (JWR).
John W
JW
Rose