[Residual relaxant block due to pseudocholinesterase deficiency - First manifestation in an elderly patient].
Pseudocholinesterase or butyrylcholinesterase (BChE) inactivates the relaxant drugs mivacurium and suxamethonium. A deficiency in plasma activity of this enzyme may result in prolonged muscular paralysis and subsequently the need for an extended duration of mechanical ventilation. We report the case of a 65-year-old patient who was diagnosed with butyrylcholinesterase deficiency for the first time during elective surgery. Neuromuscular monitoring constitutes a central diagnostic asset in ensuring patient safety.
Marc
M
Zoller
Stefan
S
Walther
D000368:Aged; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D001049:Apnea; D002091:Butyrylcholinesterase / Q000097:blood / Q000172:deficiency*; D006801:Humans; D058926:Intraoperative Awareness; D007546:Isoquinolines / Q000009:adverse effects* / Q000493:pharmacokinetics; D008297:Male; D008661:Metabolism, Inborn Errors / Q000503:physiopathology*; D000077590:Mivacurium; D016343:Monitoring, Intraoperative; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D011229:Preanesthetic Medication; D013390:Succinylcholine / Q000009:adverse effects* / Q000493:pharmacokinetics
D007546:Isoquinolines; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D002091:Butyrylcholinesterase; D013390:Succinylcholine