P300 binds to and acetylates MTA2 to promote colorectal cancer cells growth.
MTA2 is a member of metastasis associated family, which is highly expressed in several solid tumors and associated with tumor cells migration and invasion. Here, we report that MTA2 is acetylated at K152 and histone acetyltransferase p300 binds to and acetylates MTA2. Furthermore, mutation of the MTA2 acetylation site inhibits the growth of colorectal cancer cells and migration and invasion of Rat1 fibroblasts. These results reveal a novel post-translational regulation of MTA2 by the way of p300-dependent acetylation, which is important for tumor cells growth and migration and provides a potential target for clinical cancer research.
Department of Radiology, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Jun
J
Zhou
Department of Radiology, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China. Electronic address: songhuazhan.sg@gmail.com.
Songhua
S
Zhan
Department of Radiology, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Wenli
W
Tan
Department of Radiology, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Ruixin
R
Cheng
Department of Radiology, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Hangjun
H
Gong
Department of Radiology, Shu Guang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China.
Qiong
Q
Zhu
D000107:Acetylation; D000595:Amino Acid Sequence; D000818:Animals; D015179:Colorectal Neoplasms / Q000378:metabolism / Q000473:pathology*; D050881:E1A-Associated p300 Protein / Q000378:metabolism*; D006655:Histone Deacetylases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding; D012097:Repressor Proteins / Q000737:chemistry / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
D012097:Repressor Proteins; D050881:E1A-Associated p300 Protein; C494360:EP300 protein, human; C120917:MTA2 protein, human; D006655:Histone Deacetylases
Acetylation; Cell growth; MTA2; Migration; P300