[Expression and significance of phosphated signal transducer and activator of transcription 3 and p53 protein in laryngeal squamous cell carcinoma].
OBJECTIVE
To investigate the expression and clinical significance of phosphated signal transducer and activator of transcription 3 (p-STAT3) and p53 protein in laryngeal squamous cell carcinoma (LSCC), and the relationship between the two genes.


METHODS
Formalin-fixed and paraffin-embedded tissues, which came from 60 cases of LSCC and 32 samples of normal mucosa over 2.0 cm away from tumor margin in 32 patients with total or subtotal laryngectomy were detected for the expression of p-STAT3 and p53 protein by in SP immunohistochemistry. Micro-image analysis system was used to determine the optical density,and the result was analyzed statistically.


RESULTS
There is over expression of p-STAT3 and p53 protein in LSCC. The expression of p-STAT3 and p53 protein in LSCC was associated with clinical stage and lymph nodal metastases (P < 0.05). There was a positive correlation between the expression of p-STAT3 and P53 protein. The correlation coefficient (r) was 0.6558 (P < 0.01).


CONCLUSIONS
The expression of p-STAT3 and p53 protein may play an important role in the tumorigenesis,metastases and poor prognosis of LSCC. There was a positive correlation between the over expression of p-STAT3 and p53 protein in LSCC.
Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.
Lili
L
Dai
Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.
Tingyan
T
Liu
Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.
Xuehua
X
Zhou
Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.
Qingyu
Q
Wei
Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.
Yuan
Y
Li
Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.
Caiuia
C
Cui
Department of Otolaryngology-Head and Neck Surgery, the Affiliated Hospital of Hangzhou Normal University, Hangzhou, 310015, China.
Mao
M
Li
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010766:Phosphorylation; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D000077195:Squamous Cell Carcinoma of Head and Neck; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53