Use of Magnetic Resonance Imaging as Well as Clinical Disease Activity in the Clinical Classification of Multiple Sclerosis and Assessment of Its Course: A Report from an International CMSC Consensus Conference, March 5-7, 2010.
It has recently been suggested that the Lublin-Reingold clinical classification of multiple sclerosis (MS) be modified to include the use of magnetic resonance imaging (MRI). An international consensus conference sponsored by the Consortium of Multiple Sclerosis Centers (CMSC) was held from March 5 to 7, 2010, to review the available evidence on the need for such modification of the Lublin-Reingold criteria and whether the addition of MRI or other biomarkers might lead to a better understanding of MS pathophysiology and disease course over time. The conference participants concluded that evidence of new MRI gadolinium-enhancing (Gd+) T1-weighted lesions and unequivocally new or enlarging T2-weighted lesions (subclinical activity, subclinical relapses) should be added to the clinical classification of MS in distinguishing relapsing inflammatory from progressive forms of the disease. The consensus was that these changes to the classification system would provide more rigorous definitions and categorization of MS course, leading to better insights as to the evolution and treatment of MS.
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Stuart D
SD
Cook
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Suhayl
S
Dhib-Jalbut
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Peter
P
Dowling
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Luca
L
Durelli
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Corey
C
Ford
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Gavin
G
Giovannoni
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
June
J
Halper
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Colleen
C
Harris
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Joseph
J
Herbert
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
David
D
Li
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
John A
JA
Lincoln
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Robert
R
Lisak
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Fred D
FD
Lublin
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Claudia F
CF
Lucchinetti
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Wayne
W
Moore
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Robert T
RT
Naismith
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Carlos
C
Oehninger
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Jack
J
Simon
University of Medicine and Dentistry of New Jersey, Newark, NJ, USA (SDC); Department of Neurology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, NJ (SDJ); VA Medical Center-East Orange, East Orange, NJ, USA (PD); Department of Clinical and Biological Sciences, San Luigi Gonzaga Medical School, University of Torino, Orbassano, Italy (LD); Multiple Sclerosis Clinic, University of New Mexico Health Sciences Center, Albuquerque, NM, USA (CF); Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, Whitechapel, London, UK (GG); Consortium of Multiple Sclerosis Centers, Hackensack, NJ, USA (J Halper); Multiple Sclerosis Clinic, Foothills Medical Centre, Calgary, Alberta, Canada (CH); MS Comprehensive Care Center, NYU Langone Medical Center, New York, NY, USA (J Herbert); MS Clinic, University of British Columbia Hospital, Vancouver, British Columbia, Canada (DL); MS Research Group, University of Texas Health, Houston, TX, USA (JAL); Comprehensive Clinical and Research MS Center, Wayne State University, Detroit, MI, USA (RL); Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Mount Sinai School of Medicine, New York, NY, USA (FDL); Department of Neurology, Mayo Clinic, Rochester, MN, USA (CFL); Vancouver General Hospital, Vancouver, British Columbia, Canada (WM); Department of Neurology, Washington University, St. Louis, MO, USA (RTN); LACTRIMS and Institute of Neurology, Montevideo, Uruguay (CO); VA Medical Center, Portland, OR, USA (JS); and Biostatistics Unit, Department of Health Sciences, University of Genoa, Genoa, Italy (MPS).
Maria Pia
MP
Sormani