Tc1 clonal T cell expansion during chronic graft-versus-host disease-associated hypereosinophilia.
Although hypereosinophilia (HE) associated with chronic graft-versus-host disease (GVHD) has long been recognized, biological data on this phenomenon are scarce. Here we compare patients with chronic GVHD with HE together with a clonal T cell expansion and control patients with acute or chronic GVHD but without HE. These clonal expansions share a CD8(+) TC1 phenotype rather than a CD4(+) Th2 profile. In contrast to the drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, these allogeneic CD8(+) clones do not recognize the epitopes of herpesviruses. Furthermore, these TC1 clones do not produce IL-17 as described in the DRESS syndrome.
Departement d'Immunologie, INSERM UMRS-940, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Emmanuel
E
Clave
Service d'Hématologie-Greffe, AP-HP Hôpital Saint Louis, Paris, France.
Aliénor
A
Xhaard
Departement d'Immunologie, INSERM UMRS-940, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France.
Corrine
C
Douay
Service d'Hématologie, AP-HP Hôpital Avicenne, Paris, France.
Lionel
L
Adès
Service d'Hématologie Biologique, AP-HP Hôpital Saint Louis, Paris, France.
Jean Michel
JM
Cayuela
Service d'Hématologie-Greffe, AP-HP Hôpital Saint Louis, Paris, France.
Régis
R
Peffault de Latour
Service d'Hématologie-Greffe, AP-HP Hôpital Saint Louis, Paris, France.
Marie
M
Robin
Departement d'Immunologie, INSERM UMRS-940, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Service d'Immunologie, AP-HP Hôpital Saint Louis, Paris, France.
Antoine
A
Toubert
Departement d'Immunologie, INSERM UMRS-940, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Paris, France; Service d'Hématologie-Greffe, AP-HP Hôpital Saint Louis, Paris, France. Electronic address: gerard.socie@sls.aphp.fr.
Gérard
G
Socié
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D049109:Cell Proliferation; D002908:Chronic Disease; D002999:Clone Cells; D004802:Eosinophilia / Q000150:complications / Q000276:immunology / Q000473:pathology*; D004804:Eosinophils / Q000276:immunology / Q000473:pathology; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000276:immunology / Q000473:pathology*; D019337:Hematologic Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*
D000970:Antineoplastic Agents
Eosinophilia; Graft-versus-host disease