Two new secondary metabolites from Xylaria sp. cfcc 87468.
A new isocoumarin glycoside, 3R-(+)-5-O-[6'-O-acetyl]-α-D-glucopyranosyl-5-hydroxymellein (1), and a new phenylethanol glycoside, (-)-phenylethyl-8-O-α-L-rhamno-pyranoside (2), were isolated from the ethyl acetate extract of the fungus Xylaria sp. cfcc 87468, together with five known steroids, β-sitosterol (3), stigmast-4-en-3-one (4), ergosterol (5), (22E)-cholesta-4,6,8(14),22-tetraen-3-one (6), and 4α-methyl- ergosta-8(14),24(28)-dien-3β-ol (7). The structures of compounds 1 and 2 were elucidated by MS, extensive 1D and 2D NMR spectroscopy, and the circular dichroism (CD) spectroscopy.
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. wangfuqian.c@163.com.
Fuqian
F
Wang
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. mshss880910@163.com.
Shishi
S
Han
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. huyaoshi@sina.com.cn.
Song
S
Hu
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. yongboxue@mail.hust.edu.cn.
Yongbo
Y
Xue
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. jpwang1001@163.com.
Jianping
J
Wang
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. xhf991030@tom.com.
Hongfeng
H
Xu
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. chenglu19810620@163.com.
Lu
L
Chen
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. zhanggen888@126.com.
Geng
G
Zhang
Department of Pharmacy, Wuhan First Hospital, Wuhan 430022, Hubei, China. zhangyh@mails.tjmu.edu.cn.
Yonghui
Y
Zhang
D002942:Circular Dichroism; D049934:Isocoumarins / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D020409:Molecular Motor Proteins; D009005:Monosaccharides / Q000737:chemistry* / Q000302:isolation & purification; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification; D013098:Xylariales / Q000737:chemistry*
C000591494:5-O-(6'-O-acetyl)-alpha-D-glucopyranosyl-5-hydroxymellein; D049934:Isocoumarins; D020409:Molecular Motor Proteins; D009005:Monosaccharides; D013256:Steroids; C000591495:phenylethyl-8-O-alpha-L-rhamnopyranoside