Toxicity of phthalate esters exposure to carp (Cyprinus carpio) and antioxidant response by biomarker.
To study the toxic effects of phthalate esters on the aquatic creatures, carps were exposed to dibutyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) of six different concentrations for 96 h-LC50 measurements. It shows that the 96 h-LC50 is 16.30 and 37.95 mg L(-1), thus the safe concentration (1/10LC(50)) is 1.63 mg L(-1). The activities of xanthine oxidase (XOD) and catalase (CAT) were measured in liver to carp exposure for single or combinations of DBP and DEHP. The quantity of malonic dialdehyde (MDA) was also measured in the same way. XOD, CAT and MDA had shown an evident change while exposure time and concentration increased, combined exposure can aggravate this change. They might be used as early warning indicators and monitors, and have potentials in the ecological risk assessment.
College of Environmental Science and Engineering, Donghua University, Shanghai, 201620, People's Republic of China, zxx@dhu.edu.cn.
Xiaoxiang
X
Zhao
Ying
Y
Gao
Mingliang
M
Qi
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D002347:Carps / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism*; D003993:Dibutyl Phthalate / Q000633:toxicity*; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D008099:Liver / Q000201:enzymology; D008315:Malondialdehyde / Q000378:metabolism; D023382:Toxicity Tests, Acute; D014969:Xanthine Oxidase / Q000378:metabolism*
D000975:Antioxidants; D015415:Biomarkers; D003993:Dibutyl Phthalate; D008315:Malondialdehyde; D004051:Diethylhexyl Phthalate; D002374:Catalase; D014969:Xanthine Oxidase