Chemical composition and general toxicity of essential oils extracted from the aerial parts of Artemisia armeniaca Lam. and A. incana (L.) Druce growing in Iran.
The essential oils of the aerial parts of A. armeniaca and A. incana, collected from Arasbaran area (East Azarbaijan province, Iran) were extracted by hydrodistillation and analyzed by GC-MS. In total, 16 and 40 constituents were identified and quantified in the oils of A. armeniaca and A. incana representing 80.5% and 84.6% of the oils, respectively. The essential oil of A. armeniaca was mainly composed of non-terpene hydrocarbons (24.8%). The major components of the oil were α-pinene (10.7%), nonadecane (10.0%), 6,10,14-trimethyl-2-pentadecanone (9.4%), spathulenol (7.8%) and Z-verbenol (5.8%). The essential oil of A. incana was dominated by oxygenated monoterpenes (41.6%), with camphor (20.4%), 1,8-cineol (10.3%), Z-verbenol (8.7%), β-thujone (8.3%) and α-thujone (5.6%), as major components. The essential oils were also subjected to general toxicity assay using brine shrimp lethality method. The toxicity profile of both oils indicated some degree of toxicity in comparison with podophyllotoxin.
Department of Pharmacognosy and Biotechnology, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.
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M
Mojarrab
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, I.R. Iran ; Department of Pharmacognosy, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.
A
A
Delazar
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.
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S
Esnaashari
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, I.R. Iran ; Department of Pharmacognosy, School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, I.R. Iran.
F Heshmati
FH
Afshar
Artemisia armeniaca; Artemisia incana; Brine shrimp; General toxicity; Monoterpene