Nodular lymphoid hyperplasia of the stomach in a patient with multiple submucosal tumors.
Nodular lymphoid hyperplasia of the stomach is a rare lymphoproliferative disorder. Here, we report a 38-year-old man who presented with multiple submucosal tumors of the stomach. Histologically, the lesions were characterized by multiple discrete submucosal nodules of lymphoid cells. The infiltrates between the lymphoid follicles were composed mainly of medium-sized lymphoid cells with abundant clear cytoplasm, as well as a few large cells with vesicular nuclei. The gastric mucosa exhibited multifocal lymphoid aggregates and some of the epithelial cells were infiltrated by small lymphocytes mimicking lymphoepithelial lesions. Histopathology was consistent with mucosa-associated lymphoid tissue lymphoma. However, the infiltrating lymphoid cells were positive for CD2, CD3, CD5, and CD7. In addition, polymerase chain reaction analysis of the immunoglobulin heavy chain and T-cell receptor gene rearrangements demonstrated polyclonality. This case was diagnosed as reactive lymphoid hyperplasia of the stomach.
Department of Internal Medicine, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Ja Young
JY
Jeon
Department of Gastroenterology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Sun Gyo
SG
Lim
Department of Pathology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Jang Hee
JH
Kim
Department of Gastroenterology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Kee Myung
KM
Lee
Department of Laboratory Medicine, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Sung Ran
SR
Cho
Department of Pathology, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.
Jae Ho
JH
Han
Lymphoid hyperplasia; MALToma; Stomach