An anticancer drug to probe non-specific protein-DNA interactions.
A visible fluorescence switch of an eminent anti-carcinogen, ellipticine has been used to probe non-specific protein-DNA interaction. The unique pattern of protein-DNA complexation is depicted for the first time through field emission scanning electron microscopy (FE-SEM) images and spectroscopic techniques.
IISER-Pune, Maharashtra (411008), India. p.hazra@iiserpune.ac.in.
Abhigyan
A
Sengupta
Raj Kumar
RK
Koninti
Krishna
K
Gavvala
Nirmalya
N
Ballav
Partha
P
Hazra
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002417:Cattle; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004611:Ellipticines / Q000737:chemistry* / Q000494:pharmacology; D031541:Fluorescence Resonance Energy Transfer; D011485:Protein Binding / Q000187:drug effects; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism
D000970:Antineoplastic Agents; D004611:Ellipticines; D011506:Proteins; D012709:Serum Albumin; C034192:ellipticine; D012710:Serum Albumin, Bovine; D004247:DNA; C427203:calf thymus DNA