[The phenomenon of release activity and the hypothesis of "spatial" homeostasis].
When analyzing the technology of multiple sequential reductions in concentration of parent substance we have discovered a novel physical phenomenon. It was shown that dilutions of parent substance prepared using this technology have one common peculiarity - they are capable to exert direct modifying effect on parent substance altering spatial structure of parent substance and consequently its physical, chemical and biological properties. Technologically processed dilutions also exert activity when they do not contain molecules of parent substance. We have defined a newly revealed modifying activity manifested in the process of multiple sequential reductions in concentrations and associated with vehicle as release-activity while the drugs exerting modifying activity we have called release-active drugs. Having analyzed the ceffects of a drug in the whole range of doses - toxic, therapeutic, low doses as well as release-active form of a drug we came to a conclusion that there were supramolecular spatial matrices with the structure, which was identical to the one of a certain substance, and combines body molecules into semantic molecular assemblies. All biological systems unlike nonliving nature have dual structure - both individual and specific ones. Enhancement in any body spatial complexity is its key feature from the point of view of evolution development; that is why all processes - both normal physiologic and pathologic ones - shall comply with superiority of preservation of a body spatial structure hierarchy (hypothesis of spatial homeostasis).
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Epstein
D000818:Animals; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry; D010600:Pharmacology
D004364:Pharmaceutical Preparations