Dynamics of ezrin and EBP50 in regulating microvilli on the apical aspect of epithelial cells.
Microvilli are found on the apical surface of epithelial cells. Recent studies on the microvillar proteins ezrin and EBP50 (ezrin/radixin/moesin-binding phosphoprotein of 50 kDa) have revealed both the dynamics and the regulation of microvillar components, and how a dynamic ezrin phosphocycle is necessary to confine microvilli to the apical membrane. In the present review, we first summarize the background to allow us to place these advances in context.
*Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, U.S.A.
Raghuvir
R
Viswanatha
*Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, U.S.A.
Anthony
A
Bretscher
*Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, U.S.A.
Damien
D
Garbett
D000818:Animals; D003598:Cytoskeletal Proteins / Q000378:metabolism / Q000502:physiology*; D004847:Epithelial Cells / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D008871:Microvilli / Q000378:metabolism*; D010750:Phosphoproteins / Q000502:physiology*; D015398:Signal Transduction; D017923:Sodium-Hydrogen Exchangers / Q000502:physiology*; D000099149:Ezrin
D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D010750:Phosphoproteins; D017923:Sodium-Hydrogen Exchangers; D000099149:Ezrin; C093376:sodium-hydrogen exchanger regulatory factor; C071058:moesin; C071776:radixin