Structures of soluble guanylate cyclase: implications for regulatory mechanisms and drug development.
Activation of cGMP synthesis leads to vasodilation, and is an important mechanism in clinical treatment of angina, heart failure, and severe peripheral and pulmonary hypertension. The nitric oxide-responsive sGC (soluble guanylate cyclase) has been the target of recent drug discovery efforts. The present review surveys recent data on the structure and regulation of sGC, and the prospects of new avenues for therapeutic intervention.
*Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, U.K.
Opher
O
Gileadi
D000494:Allosteric Regulation; D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D020134:Catalytic Domain; D055808:Drug Discovery; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D017433:Protein Structure, Secondary
D006162:Guanylate Cyclase