Regulation of EB1/3 proteins by classical MAPs in neurons.
Microtubules (MTs) are key cytoskeletal elements in developing and mature neurons. MT reorganization underlies the morphological changes that occur during neuronal development. Furthermore, MTs contribute to the maintenance of neuronal architecture, enable intracellular transport and act as scaffolds for signaling molecules. Thus, a fine-tuned regulation of MT dynamics and stability is crucial for the correct differentiation and functioning of neurons. Different types of proteins contribute to the regulation of the MT state, such as plus-end tracking proteins (+TIPs), which interact with the plus-ends of growing microtubules, and classical microtubule-associated proteins (MAPs), which bind along the microtubule lattice. Recent evidence indicates that MAPs interplay with End Binding Proteins (EBs), the core +TIPs, in neuronal cells. This might contribute to the orchestrated regulation of MT dynamics in neurons. In this mini-review article, we address recent research on the neuronal crosstalk between EBs and classical MAPs and speculate on its possible functional relevance.
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM); Universidad Autónoma de Madrid; Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED); Madrid, Spain.
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Sayas
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM); Universidad Autónoma de Madrid; Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED); Madrid, Spain.
Jesús
J
Avila
D000818:Animals; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D011485:Protein Binding
C405804:EB1 microtubule binding proteins; D008869:Microtubule-Associated Proteins
+TIPs; EB proteins; MAP1B; MAP2; MAPs; microtubule dynamics; neuronal development