Indolent peripheral T-cell lymphoma involving the gastrointestinal tract.
We describe an unusual case of indolent peripheral T-cell lymphoma with multifocal involvement of the gastrointestinal tract. The patient, a 42-year-old Asian man, has been followed up for more than 10 years without chemotherapy and multiple gastrointestinal biopsies showing similar findings. Histologically, the neoplasm expanded into the lamina propria and/or focally extended into the submucosa and was composed of small- to medium-sized lymphocytes with slightly irregular nuclear contours and clear cytoplasm and rare large lymphocytes. The tumor cells were positive for CD3, CD8, granzyme B, and TIA-1 (subset) and negative for CD5, CD56, and Epstein-Barr virus-encoded RNA. Molecular studies for T-cell receptor γ and/or β chain gene rearrangement demonstrated the same clone at different sites and times during the course of the disease. Rare cases of indolent peripheral T-cell lymphoma of the gastrointestinal tract have been previously described and need to be further characterized to avoid the use of aggressive chemotherapy.
Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA, 77030; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA, 38105. Electronic address: vasiliki.leventaki@stjude.org.
Vasiliki
V
Leventaki
Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA, 77030.
John T
JT
Manning
Department of Lymphoma/Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Rajayalakshmi
R
Luthra
Department of Lymphoma/Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Pramod
P
Mehta
Department of Lymphoma/Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Yasuhiro
Y
Oki
Department of Lymphoma/Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Jorge E
JE
Romaguera
Department of Hematopathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA, 77030.
L Jeffrey
LJ
Medeiros
Division of Hematopathology, University of Miami/Sylvester Cancer Centeri, FL, USA, 33136.
Francisco
F
Vega
D000328:Adult; D005770:Gastrointestinal Neoplasms / Q000276:immunology* / Q000473:pathology*; D041981:Gastrointestinal Tract / Q000276:immunology; D006801:Humans; D016411:Lymphoma, T-Cell, Peripheral / Q000276:immunology / Q000473:pathology*; D008297:Male
Gastrointestinal tract; Indolent lymphoma; NK-cell enteropathy; T-cell lymphoma