[Changes of serum leptin levels in patients with obstructive sleep apnea-hypopnea syndrome before and after treatment of surgery].
OBJECTIVE
To investigate the change of serum leptin levels in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) before and after surgery.


METHODS
The cases were divided into effective (n=44) and non-effective (n=13) groups according to PSG. The effective cases were divided into decreased (> or = 5%, n=25) and non-decreased(<5%, n=19) BMI. The level of serum leptin was detected by radioimmunoassay.


RESULTS
The level of serum leptin after treatment (9.1 +/- 2.6 microg/L) was as high as before treatment (9.3 +/- 2.3 microg/L) in 13 non-effective cases. The level of serum leptin after treatment (7.15 +/- 1.23 microg/L) was significantly decreased than before treatment (12.79 +/- 2.98 microg/L) in 25 cases of decreased BMI (> or = 5%). The level of serum leptin after treatment (7.15 +/- 1.23 microg/L) was significantly decreased than before treatment (12.79 +/- 2.98 microg/L) in 19 cases of non-decreased BMI (<5%). Leptin level of all cases showed a positive correlation with AHI (P < 0.01).


CONCLUSIONS
The level of serum leptin in patients with OSAHS are increased. The serum leptin level of effective patients with OSAHS after treatment was significantly decreased. The level of serum leptin reflects the degree of AHI in patients with OSAHS.
Department of Otolaryngology-Head and Neck Surgery, the 105th Hospital of PLA, Hefei, 230031, China.
Shengguo
S
Wang
Department of Otolaryngology-Head and Neck Surgery, the 105th Hospital of PLA, Hefei, 230031, China.
Xianping
X
Shi
Department of Otolaryngology-Head and Neck Surgery, the 105th Hospital of PLA, Hefei, 230031, China.
Benzhong
B
Zhou
Department of Otolaryngology-Head and Neck Surgery, the 105th Hospital of PLA, Hefei, 230031, China.
Longqiao
L
Li
Department of Otolaryngology-Head and Neck Surgery, the 105th Hospital of PLA, Hefei, 230031, China.
Jingtao
J
Bi
Department of Otolaryngology-Head and Neck Surgery, the 105th Hospital of PLA, Hefei, 230031, China.
L V
LV
Ling
D000328:Adult; D000368:Aged; D006801:Humans; D007432:Intraoperative Period; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000601:surgery
D020738:Leptin