Ursolic Acid provides kidney protection in diabetic rats.
BACKGROUND
Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes and the leading cause of end-stage renal failure. However, the treatment of DN is still a problem in the world. Inflammatory process plays a critical role in the development of DN. Therefore, anti-inflammatory treatment of DN is worth exploring now and in the future.


OBJECTIVE
The study aimed to evaluate the impact of ursolic acid (UA) on renal function in streptozotocin-induced diabetes.


METHODS
Rats with streptozotocin-induced diabetes were treated with UA for 16 weeks. After 16 weeks, urine albumin excretion, serum creatinine, and blood urea nitrogen were measured. In addition, renal oxidative stress level, nuclear factor kappa-B (NF-κB) activity, P-selectin expression, and kidney histopathologic changes were evaluated.


RESULTS
Sixteen weeks following streptozotocin injection, the rats produced significant alteration in renal function and increased oxidative stress, NF-κB activity, and P-selectin expression in the kidneys. Interestingly, UA significantly prevented biochemical and histopathologic changes in the kidneys associated with diabetes. Compared with untreated diabetic rats, UA treatment lowered urine albumin excretion, renal oxidative stress level, NF-κB activity, and P-selectin expression. Moreover, UA treatment also improved renal histopathologic changes in rats with diabetes.


CONCLUSIONS
UA treatment exhibited a protective effect on kidneys in diabetic rats, implying that UA could be a potential treatment for diabetic nephropathy.
Department of Internal Medicine and Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Chen
C
Ling
Department of Internal Medicine and Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Lu
L
Jinping
Department of Internal Medicine and Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Li
L
Xia
Department of Internal Medicine and Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Yang
Y
Renyong
diabetic nephropathy; nuclear factor kappa-B; oxidative stress; ursolic acid