Three new sterigmatocystin analogues from marine-derived fungus Aspergillus versicolor MF359.
During the systematic screening of active compounds from marine-derived fungi, the extract of a strain of Aspergillus versicolor MF359 isolated from a marine sponge of Hymeniacidon perleve was identified for detailed chemical investigation. Three new secondary metabolites, named hemiacetal sterigmatocystin (1), acyl-hemiacetal sterigmatocystin (2), and 5-methoxydihydrosterigmatocystin (3), together with a known compound, aversin (4), were characterized. 1 represents a first structure of sterigmatocystin hemiacetal from nature. The antibacterial activities of these identified compounds were evaluated against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Compound 3 showed activity against S. aureus and B. subtilis with MIC values of 12.5 and 3.125 μg/mL, respectively.
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Beijing, 100101, People's Republic of China.
Fuhang
F
Song
Biao
B
Ren
Caixia
C
Chen
Ke
K
Yu
Xinru
X
Liu
Yuhan
Y
Zhang
Na
N
Yang
Hongtao
H
He
Xueting
X
Liu
Huanqin
H
Dai
Lixin
L
Zhang
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D059001:Aquatic Organisms / Q000737:chemistry / Q000145:classification / Q000235:genetics; D001230:Aspergillus / Q000737:chemistry* / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D001412:Bacillus subtilis / Q000187:drug effects; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D011161:Porifera / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D017422:Sequence Analysis, DNA; D013211:Staphylococcus aureus / Q000187:drug effects; D013241:Sterigmatocystin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004271:DNA, Fungal; D013241:Sterigmatocystin