Significant association between IL23R and IL17F polymorphisms and clinical features of colorectal cancer.
Th17cells are involved in inflammatory and autoimmune diseases. These cells may be involved in pathological processes mainly producing pro-inflammatory cytokines. Recently, it was shown that the IL23/IL17 pathway plays an important role in the development of inflammatory bowel disease. In general, genes encoding cytokines are genetically polymorphic and polymorphisms in genes IL23R el IL17F were shown associated with susceptibility to Crohn's disease and ulcerative colitis which in their turn are considered as risk factors for developing colorectal cancer (CRC). Our approach is to study IL17F and IL23R polymorphisms as risk factor associated with CRC in the Tunisian population in patients and healthy controls. Interesting, we noted a significant association between IL17F and IL23R polymorphisms and tumor location (p=0.0001 and p=0.049, respectively), tumor histology (p=0.007 and p=0.049, respectively) and tumor architecture (p=0.0000000001 and p=0.07, respectively) in CRC patients. We also showed a significant association of IL17F variant with an increased risk of TNM stage III/IV (p=0.007), showing an increased risk of advanced stage. Finally, we observed a positive link between IL17F polymorphism and CRC patients with lymph nodes (p=0.0000000001) and metastasis (p=0.00000009). However, we found no evidence to support a significant association between IL17F and IL23R polymorphisms and colorectal cancer susceptibility. Our findings suggest that IL17F and IL23R polymorphisms were significantly associated with clinical features variables. The IL17F cytokine appear to be involved in the control of tumor growth and invasion of gastrointestinal tumors. IL17 and IL23 polymorphisms or those of their receptors as important determinants of susceptibility to colorectal cancer are still subject to questioning.
Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis El Manar, University of Tunis, Tunisia. Electronic address: inesomrane@hotmail.fr.
Inés
I
Omrane
Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis El Manar, University of Tunis, Tunisia.
Olfa
O
Baroudi
Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis El Manar, University of Tunis, Tunisia.
Karim
K
Bougatef
Gastroenterology Service, Salah Azaiez hospital of Tunis, Tunisia.
Amel
A
Mezlini
Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis El Manar, University of Tunis, Tunisia.
Ahmed
A
Abidi
Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis El Manar, University of Tunis, Tunisia.
Imen
I
Medimegh
Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis El Manar, University of Tunis, Tunisia.
Nejla
N
Stambouli
Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis El Manar, University of Tunis, Tunisia.
Hager
H
Ayari
Laboratory of Anatomy and Pathology, Charles Nicolle Hospital of Tunis, Tunisia.
Nadia
N
Kourda
Laboratory of Diagnosis and Molecular Genetics, Centre Jean Perrin, Clermont Ferrand, France.
Nancy
N
Uhrhammer
Laboratory of Diagnosis and Molecular Genetics, Centre Jean Perrin, Clermont Ferrand, France.
Yves Jean
YJ
Bignon
Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis El Manar, University of Tunis, Tunisia.
Amel
A
Benammar Elgaaied
Laboratory of Human Genetics Immunology and Pathology, Faculty of Sciences Tunis El Manar, University of Tunis, Tunisia.
Raja
R
Marrakchi
D000368:Aged; D063646:Carcinogenesis; D002277:Carcinoma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D004252:DNA Mutational Analysis; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D020381:Interleukin-17 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D018123:Receptors, Interleukin / Q000235:genetics* / Q000378:metabolism; D014416:Tunisia
C515500:IL23R protein, human; D018836:Inflammation Mediators; D020381:Interleukin-17; D018123:Receptors, Interleukin
Clinical features; Colorectal cancer; IL17/IL23R; Immunity; Polymorphism; Th17 cells