Robust nonenzymatic hybrid nanoelectrocatalysts for signal amplification toward ultrasensitive electrochemical cytosensing.
We have discovered that magnetic Fe3O4 nanoparticles exhibit an intrinsic catalytic activity toward the electrochemical reduction of small dye molecules. Metallic nanocages, which act as efficient signal amplifiers, can be attached to the surface of Fe3O4 beads to further enhance the catalytic electrochemical signals. The Fe3O4@nanocage core-satellite hybrid nanoparticles show significantly more robust electrocatalytic activities than the enzymatic peroxidase/H2O2 system. We have further demonstrated that these nonenzymatic nanoelectrocatalysts can be used as signal-amplifying nanoprobes for ultrasensitive electrochemical cytosensing.
Department of Chemistry and Biochemistry, University of South Carolina , Columbia, South Carolina 29208, United States.
Tingting
T
Zheng
Qingfeng
Q
Zhang
Sheng
S
Feng
Jun-Jie
JJ
Zhu
Qian
Q
Wang
Hui
H
Wang
D015374:Biosensing Techniques / Q000379:methods*; D002384:Catalysis; D004396:Coloring Agents / Q000737:chemistry; D055664:Electrochemical Techniques; D005290:Ferric Compounds / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057230:Limit of Detection; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013696:Temperature
D004396:Coloring Agents; D005290:Ferric Compounds; C000499:ferric oxide; D012834:Silver; D010165:Palladium