(18)F-FLT PET/CT in Patients with Gastric Carcinoma.
The aim of the study was to evaluate the usefulness of 18F-FLT PET/CT in the detection and differentiation of gastric cancers (GC). 104 consecutive patients (57 cases of adenocarcinoma tubulare (G2 and G3), 17 cases of mucinous adenocarcinoma, 6 cases of undifferentiated carcinoma, 14 cases of adenocarcinoma partim mucocellulare, and 10 cases of end stage gastric cancer) with newly diagnosed advanced gastric cancer were examined with FLT PET/CT. For quantitative and comparative analyses, the maximal standardized uptake value (SUVmax) was calculated for both the tumors and noninvaded gastric wall. Results. There were found, in the group of adenocarcinoma tubulare, SUVmax 1.5-23.1 (7.46 ± 4.57), in mucinous adenocarcinoma, SUVmax 2.3-10.3 (5.5 ± 2.4), in undifferentiated carcinoma, SUVmax 3.1-13.6 (7.28 ± 3.25), in adenocarcinoma partim mucocellulare, SUVmax 2-25.3 (7.7 ± 6.99), and, in normal gastric wall, SUVmax 1.01-2.55 (1.84 ± 0.35). For the level of 2.6 cut-off value between the normal wall and neoplasm FLT uptake from ROC analysis, all but five gastric cancers showed higher accumulation of FLT than noninfiltrated mucosa. Conclusion. Gastric cancer presents higher accumulation of 18F-FLT than normal, distended gastric mucosa. Significantly higher accumulation was shown in cancers better differentiated and with higher cellular density.
Department of Nuclear Medicine, Oncological Centre, Bydgoszcz, Poland ; Department of Positron Emission Tomography and Molecular Diagnostics, Collegium Medicum, Nicolaus Copernicus University, 85-796 Bydgoszcz, Poland.
Bogdan
B
Małkowski
Department of Oncological Surgery, Oncological Centre, 85-796 Bydgoszcz, Poland.
Tomasz
T
Staniuk
Department of Cancer Pathology and Pathomorphology, Collegium Medicum, Nicolaus Copernicus University, 85-796 Bydgoszcz, Poland.
Ewa
E
Srutek
Department of Radiology, Medical University of Gdańsk, 80-952 Gdańsk, Poland.
Tomasz
T
Gorycki
Department of Oncological Surgery, Oncological Centre, 85-796 Bydgoszcz, Poland.
Wojciech
W
Zegarski
Department of Radiology, Medical University of Gdańsk, 80-952 Gdańsk, Poland.
Michał
M
Studniarek