Specific loss of cellular L-selectin on CD4(+) T cells is associated with progressive multifocal leukoencephalopathy development during HIV infection.
HIV(+) progressive multifocal leukoencephalopathy (PML) patients had a significantly lower expression of CD62L on CD4(+) T cells (P < 0.001) when compared with HIV(+) patients who did not develop PML. CD62L expression on CD4(+) T cells did not correlate with parameters such as CDC stage, CD4(+) cell percentage (of total CD3(+) T cells), CD4(+) cell counts, virus count, or clinical parameters. Measurement of CD62L might provide a biomarker for PML risk and could prompt a treatment change and/or close monitoring.
Department of Neurology, University of Münster, Münster, Germany.
Tilman
T
Schneider-Hohendorf
Konstanze
K
Philipp
Ingo W
IW
Husstedt
Heinz
H
Wiendl
Nicholas
N
Schwab
D015415:Biomarkers / Q000032:analysis*; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry* / Q000276:immunology; D015331:Cohort Studies; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D019041:L-Selectin / Q000032:analysis*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology*; D011379:Prognosis
D015415:Biomarkers; D019041:L-Selectin