Association between migraine and ACE gene (insertion/deletion) polymorphism: the BioBIM study.
OBJECTIVE
In the present case-control study, we investigated the correlation between the common ACE insertion/deletion (I/D) polymorphism and migraine.


METHODS
Genotyping of the ACE I/D variant was performed in 502 Caucasian patients with migraine and 323 age-, sex- and race/ethnicity-matched healthy controls. We investigated associations between ACE genetic variants and sociodemographic and/or clinical features of migraineurs.


RESULTS
We found a significant association between ACE insertion/insertion (I/I) polymorphism and lower use of pharmacological prophylaxis in migraine patients with aura and in those with chronic migraine. Moreover, ACE I/I polymorphism was significantly more common in migraine patients with aura who had a negative family history of migraine.


CONCLUSIONS
Our data suggest that although the ACE I/D polymorphism is not a direct risk factor for migraine, the ACE I/I genotype may influence the clinical feature of this disease being associated with reduced use of prophylactic agents in patients with migraine with aura and in those with chronic migraine.
Interinstitutional Multidisciplinary BioBank (BioBIM), Department of Advanced Biotechnologies & Bioimaging, IRCCS San Raffaele Pisana, Rome, Italy.
Raffaele
R
Palmirotta
Piero
P
Barbanti
Giorgia
G
Ludovici
Maria Laura
ML
De Marchis
Cristiano
C
Ialongo
Gabriella
G
Egeo
Cinzia
C
Aurilia
Luisa
L
Fofi
Pasquale
P
Abete
Antonella
A
Spila
Patrizia
P
Ferroni
David
D
Della-Morte
Fiorella
F
Guadagni
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000235:genetics* / Q000473:pathology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A