Nutraceuticals in the prophylaxis of pediatric migraine: Evidence-based review and recommendations.
BACKGROUND
The literature on complementary and alternative medicine (CAM) is expanding. One of the most common conditions for which CAM is studied in the pediatric population is migraine. Nutraceuticals are a form of CAM that is being used for pediatric migraine prophylaxis.


METHODS
A literature search was carried out in order to identify both observational studies and randomized controlled trials on the use of nutraceuticals for the prophylaxis of pediatric migraine. Adult studies on included nutraceuticals were also reviewed.


METHODS
Thirty studies were reviewed on six different nutraceuticals: butterbur, riboflavin, ginkgolide B, magnesium, coenzyme Q10 and polyunsaturated fatty acids.


CONCLUSIONS
Overall, the quality of the evidence for the use of nutraceuticals in pediatric migraine prophylaxis is poor. Further research needs to be done in order to study the efficacy of nutraceuticals for the prophylaxis of pediatric migraine.
Children's Hospital of Eastern Ontario, ON, Canada University of Ottawa, ON, Canada sorr@cheo.on.ca.
Serena L
SL
Orr
Children's Hospital of Eastern Ontario, ON, Canada University of Ottawa, ON, Canada.
Sunita
S
Venkateswaran
D002648:Child; D019587:Dietary Supplements; D019317:Evidence-Based Medicine; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use; D046934:Ginkgolides / Q000627:therapeutic use; D006801:Humans; D007783:Lactones / Q000627:therapeutic use; D008274:Magnesium / Q000627:therapeutic use; D008881:Migraine Disorders / Q000517:prevention & control*; D064887:Observational Studies as Topic; D036901:Petasites; D016032:Randomized Controlled Trials as Topic; D012256:Riboflavin / Q000627:therapeutic use; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use
D005231:Fatty Acids, Unsaturated; D046934:Ginkgolides; D007783:Lactones; D014451:Ubiquinone; C045856:ginkgolide B; C024989:coenzyme Q10; D008274:Magnesium; D012256:Riboflavin
Pediatric; headache; migraine; migraine prophylaxis; nutraceutical