Systemic effects of wood smoke in a short-term experimental exposure study of atopic volunteers.
OBJECTIVE
To investigate whether short-term systemic effects of wood smoke occurred in atopic subjects after experimental wood smoke exposures.


METHODS
A double-blind climate chamber study was conducted on 20 healthy atopic subjects with exposures to filtered air and wood smoke. Pneumoproteins, coagulation and adhesion factors, and cytokines were measured. Heart rate was monitored with pulse monitors. Data were analyzed with mixed models.


RESULTS
Few differences in the outcomes were observed. Plasma tissue factor remained elevated during filtered air exposure (P = 0.002). P-selectin declined independent of exposure (P = 0.0006). Interleukin-6 increased after filtered air (P = 0.03).


CONCLUSIONS
The study confirmed previous observations among nonatopics of limited changes after a 3-hour wood smoke exposure.
From the Section of Environment Work and Health (Drs Bønløkke, Riddervold, and Sigsgaard), Institute of Public Health, University of Aarhus, Aarhus, Denmark; Section of Biostatistics (Ms Grønborg), Institute of Public Health, University of Aarhus, Aarhus, Denmark; Department of Clinical Biochemistry and Immunology (Drs Skogstrand and Hougaard), Statens Serum Institut, Copenhagen, Denmark; and Department of Occupational and Environmental Medicine (Dr Barregard), Sahlgrenska University Hospital and Academy, University of Gothenburg, Gothenburg, Sweden.
Jakob Hjort
JH
Bønløkke
Ingunn Skogstad
IS
Riddervold
Therese Koops
TK
Grønborg
Kristin
K
Skogstrand
David M
DM
Hougaard
Lars
L
Barregard
Torben
T
Sigsgaard
D000328:Adult; D000393:Air Pollutants / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood*; D018592:Cross-Over Studies; D016207:Cytokines / Q000097:blood; D004311:Double-Blind Method; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D064368:Healthy Volunteers; D006339:Heart Rate; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000503:physiopathology*; D015850:Interleukin-6 / Q000097:blood; D008168:Lung / Q000378:metabolism; D008297:Male; D015233:Models, Statistical; D019007:P-Selectin / Q000097:blood; D037663:Pulmonary Surfactant-Associated Protein D / Q000097:blood; D012906:Smoke / Q000009:adverse effects*; D013925:Thromboplastin / Q000378:metabolism; D014598:Uteroglobin / Q000097:blood; D014934:Wood
D000393:Air Pollutants; D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6; D019007:P-Selectin; D037663:Pulmonary Surfactant-Associated Protein D; C556389:SCGB1A1 protein, human; D012906:Smoke; D013925:Thromboplastin; D014598:Uteroglobin