Free and cued recall memory in Parkinson's disease associated with amnestic mild cognitive impairment.
The hypothesis has been advanced that memory disorders in individuals with Parkinson's disease (PD) are related to either retrieval or consolidation failure. However, the characteristics of the memory impairments of PD patients with amnestic mild cognitive impairment have not been clarified. This study was aimed at investigating whether memory deficits in PD patients with amnestic mild cognitive impairment (PDaMCI) are due to failure of retrieval or consolidation processes. Sixteen individuals with PDaMCI, 20 with amnestic mild cognitive impairment without PD (aMCINPD), and 20 healthy controls were recruited. Participants were administered the Free and Cued Selective Reminding Test. An index of cueing was computed for each subject to capture the advantage in retrieval of cued compared to free recall. Individuals with PDaMCI performed worse than healthy controls on the free recall (p<0.01) but not the cued recall (p>0.10) task, and they performed better than aMCINPD subjects on both recall measures (p<0.01). The index of cueing of subjects with PD was comparable to that of healthy controls (p>0.10) but it was significantly higher than that of the aMCINPD sample (p<0.01). Moreover, PD patients' performance on free recall trials was significantly predicted by scores on a test investigating executive functions (i.e., the Modified Card Sorting Test; p = 0.042). Findings of the study document that, in subjects with amnestic mild cognitive impairment associated to PD, episodic memory impairment is related to retrieval rather than to consolidation failure. The same data suggest that, in these individuals, memory deficits might be due to altered frontal-related executive functioning.
Behavioural and Clinical Neurology Laboratory, I.R.C.C.S. Fondazione S. Lucia, Rome, Italy.
Alberto
A
Costa
Behavioural and Clinical Neurology Laboratory, I.R.C.C.S. Fondazione S. Lucia, Rome, Italy.
Marco
M
Monaco
Behavioural and Clinical Neurology Laboratory, I.R.C.C.S. Fondazione S. Lucia, Rome, Italy.
Silvia
S
Zabberoni
Behavioural and Clinical Neurology Laboratory, I.R.C.C.S. Fondazione S. Lucia, Rome, Italy.
Antonella
A
Peppe
Behavioural and Clinical Neurology Laboratory, I.R.C.C.S. Fondazione S. Lucia, Rome, Italy.
Roberta
R
Perri
Behavioural and Clinical Neurology Laboratory, I.R.C.C.S. Fondazione S. Lucia, Rome, Italy ; Dipartimento di Medicina dei Sistemi, Rome University "Tor Vergata", Rome, Italy.
Lucia
L
Fadda
Behavioural and Clinical Neurology Laboratory, I.R.C.C.S. Fondazione S. Lucia, Rome, Italy.
Francesca
F
Iannarelli
Behavioural and Clinical Neurology Laboratory, I.R.C.C.S. Fondazione S. Lucia, Rome, Italy ; Dipartimento di Medicina dei Sistemi, Rome University "Tor Vergata", Rome, Italy.
Carlo
C
Caltagirone
Behavioural and Clinical Neurology Laboratory, I.R.C.C.S. Fondazione S. Lucia, Rome, Italy ; Dipartimento di Medicina dei Sistemi, Rome University "Tor Vergata", Rome, Italy.
Giovanni A
GA
Carlesimo
D000368:Aged; D000647:Amnesia / Q000523:psychology*; D060825:Cognitive Dysfunction / Q000523:psychology*; D003463:Cues; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D010300:Parkinson Disease / Q000523:psychology*