Stabilized porous liposomes with encapsulated Gd-labeled dextran as a highly efficient MRI contrast agent.
A highly efficient contrast agent for magnetic resonance imaging was developed by encapsulating gadolinium within a stabilized porous liposome. The highly porous membrane leads to a high relaxivity of the encapsulated Gd. The stability of the liposome was improved by forming a polymer network within the bilayer membrane.
Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. zcheng@seas.upenn.edu.
Zhiliang
Z
Cheng
Ajlan
A
Al Zaki
Ian W
IW
Jones
Henry K
HK
Hall
Craig A
CA
Aspinwall
Andrew
A
Tsourkas
D003287:Contrast Media / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry*; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives* / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*; D016062:Porosity
D003287:Contrast Media; D003911:Dextrans; D006571:Heterocyclic Compounds; D008081:Liposomes; D009942:Organometallic Compounds; D010713:Phosphatidylcholines; C015219:fluorescein isothiocyanate dextran; C077390:1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholine; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium; D016650:Fluorescein-5-isothiocyanate