Integrated text mining and chemoinformatics analysis associates diet to health benefit at molecular level.
Awareness that disease susceptibility is not only dependent on genetic make up, but can be affected by lifestyle decisions, has brought more attention to the role of diet. However, food is often treated as a black box, or the focus is limited to few, well-studied compounds, such as polyphenols, lipids and nutrients. In this work, we applied text mining and Naïve Bayes classification to assemble the knowledge space of food-phytochemical and food-disease associations, where we distinguish between disease prevention/amelioration and disease progression. We subsequently searched for frequently occurring phytochemical-disease pairs and we identified 20,654 phytochemicals from 16,102 plants associated to 1,592 human disease phenotypes. We selected colon cancer as a case study and analyzed our results in three directions; i) one stop legacy knowledge-shop for the effect of food on disease, ii) discovery of novel bioactive compounds with drug-like properties, and iii) discovery of novel health benefits from foods. This works represents a systematized approach to the association of food with health effect, and provides the phytochemical layer of information for nutritional systems biology research.
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Lyngby, Denmark.
Kasper
K
Jensen
School of Biological Sciences, The University of Hong Kong, Hong Kong.
Gianni
G
Panagiotou
School of Biological Sciences, The University of Hong Kong, Hong Kong.
Irene
I
Kouskoumvekaki
D000465:Algorithms; D001499:Bayes Theorem; D003110:Colonic Neoplasms / Q000628:therapy; D057225:Data Mining / Q000379:methods*; D018450:Disease Progression; D004198:Disease Susceptibility; D005502:Food; D006801:Humans; D008019:Life Style; D008055:Lipids / Q000737:chemistry; D008490:Medical Informatics / Q000379:methods*; D052756:Nutritional Sciences; D010641:Phenotype; D064209:Phytochemicals / Q000627:therapeutic use; D010944:Plants / Q000737:chemistry; D012984:Software; D049490:Systems Biology
D008055:Lipids; D064209:Phytochemicals