Cerebrospinal fluid pharmacology: an improved pharmacology approach for chinese herbal medicine research.
Despite many successful applications of Chinese herbal medicine (CHM) in the treatment and prevention of neurological diseases (ND), the fully scientific understanding of CHM's action mechanisms had been hampered for lack of appropriate methods to explore the combinatorial rules, the synergistic mechanisms, and the molecular basis of CHM. As an improved pharmacology approach, cerebrospinal fluid pharmacology (CSFP), based on the fact that cerebrospinal fluid plays an important role in the health maintenance of specific survival environment for neurons and glial cells, has been constructed and applied to CHM research for treating ND. In the present review, the concept and advantages of CSFP are briefly introduced. The approaches and key technologies of CSFP in CHM research are also collated and analyzed. Furthermore, the developing tendency of CSFP is summarized, and its framework in CHM research is also proposed. In summary, CSFP provides a new strategy not only to eliminate some barriers of CHM research for treating ND, but also to broaden the pharmacology research for bridging the gap between CHM and modern medicine. Moreover, the advancements in CSFP will bring about a conceptual move in active ingredients discovery of CHM and make a significant contribution to CHM modernization and globalization.
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China ; The Second Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China.
Yan-Qing
YQ
Wu
The Gu Lou Hospital of Traditional Chinese Medicine of Beijing, Beijing 100009, China.
Ying-Wu
YW
Zhou
The Second Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China.
Xiu-de
XD
Qin
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Sheng-Yu
SY
Hua
The Second Hospital Affiliated to Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China.
Yu-Lian
YL
Zhang
Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Li-Yuan
LY
Kang