Alkyne aminohalogenation enabled by DBU-activated N-haloimides: direct synthesis of halogenated enamines.
Activated by DBU, N-haloimides can be used as both halogen and nitrogen sources to achieve the difunctionalization of terminal alkynes, giving rise to useful halogenated enamines with high efficiency and high regio- and stereoselectivities. The cascade reaction features simple manipulation, mild conditions, a broad substrate scope, readily available reagents, and atom-economy.
Department of Chemistry, Northeast Normal University, Changchun 130024, China. liangfs112@nenu.edu.cn zhangjp162@nenu.edu.cn.
Mengru
M
Li
Haiyan
H
Yuan
Baozhong
B
Zhao
Fushun
F
Liang
Jingping
J
Zhang