Retroperitoneal liposarcoma with leiomyosarcomatous differentiation.
We herein describe a 60-year-old Japanese man with a giant retroperitoneal liposarcoma undergoing leiomyosarcomatous differentiation. He was admitted to our hospital because of a 5-month history of dysphagia and abdominal distention. Abdominal computed tomography showed a giant tumor that occupied the entire retroperitoneal space. The majority of the mass was lipomatous and low density; both a heterogenous and solid mass were also present. A giant retroperitoneal liposarcoma was diagnosed, and tumor resection was performed. At surgery, the tumor was mostly isolated from the retroperitoneum and other organs. Histopathologically, the tumor comprised well-differentiated and dedifferentiated liposarcoma with heterologous differentiation of the leiomyosarcomatous components, which is a rare phenomenon in liposarcoma. The patient was alive 3 years after the first treatment, although he has had 3 local recurrences (approximately one recurrence yearly) and has been treated by repeated resection and radiotherapy.
1 Department of Surgery, Social Insurance Gunma Chuo General Hospital, Gunma, Japan.
Masaki
M
Suzuki
Minoru
M
Fukuchi
Shinji
S
Sakurai
Hiroshi
H
Naitoh
Shinsuke
S
Kiriyama
Takaharu
T
Fukasawa
Yuichi
Y
Tabe
Hayato
H
Yamauchi
Tomonori
T
Yoshida
Hiroyuki
H
Kuwano
D002471:Cell Transformation, Neoplastic; D006801:Humans; D007890:Leiomyosarcoma / Q000473:pathology*; D008080:Liposarcoma / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012186:Retroperitoneal Neoplasms / Q000473:pathology*