Evolving indications for and trends in keratoplasty in British Columbia, Canada, from 2002 to 2011: a 10-year review.
OBJECTIVE
The aim of this study was to report the evolving indications for keratoplasty and the shift in the type of keratoplasty performed in British Columbia, Canada, over a 10-year period from 2002 to 2011.


METHODS
This was a retrospective database review of all the records of corneal transplant tissues at the Eye Bank of British Columbia, Canada, from January 2002 to December 2011. The patient demographics, indications, and types of transplant performed were analyzed.


RESULTS
A total of 4843 corneal transplants were performed in 3742 patients (1968 male and 1774 female) from January 2002 to December 2011. The number of keratoplasties performed ranged from 420 in 2008 to 578 in 2011. The top 4 indications over the 10-year period were Fuchs endothelial dystrophy (FED; 18.9%), aphakic/pseudophakic bullous keratopathy (17.4%), regraft (17.1%), and keratoconus (15.5%). Penetrating keratoplasty (PKP) accounted for 86.5% (4191 transplants) of all keratoplasties performed. Since the introduction of Descemet stripping automated endothelial keratoplasty (DSAEK) in 2007, there was a significant increase in the number of DSAEKs (P < 0.0001) performed and a statistical decline in the number of PKPs (P < 0.0001) performed. Despite only 30 deep anterior lamellar keratoplasties being performed, an increasing trend was observed after 2008 (P = 0.0087). A decreasing trend in PKPs and an increasing trend in DSAEKs were observed for surgeries performed for FED, aphakic/pseudophakic bullous keratopathy, and regraft.


CONCLUSIONS
FED has become the top indication for performing a keratoplasty over the 10-year period. There was a shift from PKP to DSAEK performed for endothelial failure. Although the number of deep anterior lamellar keratoplasty surgeries was small, there was a significant increasing trend.
*Department of Ophthalmology and Visual Sciences, Division of Cornea and External disease, University of British Columbia, Canada; †National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; ‡Pacific Laser Eye Centre, Vancouver, Canada; and §Eye Bank of British Columbia, Canada.
Johnson C H
JC
Tan
Simon P
SP
Holland
Paul J
PJ
Dubord
Gregory
G
Moloney
Martin
M
McCarthy
Sonia N
SN
Yeung
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001955:British Columbia / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D003316:Corneal Diseases / Q000453:epidemiology / Q000601:surgery*; D015715:Corneal Edema / Q000453:epidemiology / Q000601:surgery; D016039:Corneal Transplantation / Q000639:trends*; D016208:Databases, Factual; D057111:Descemet Stripping Endothelial Keratoplasty / Q000639:trends; D005125:Eye Banks / Q000706:statistics & numerical data; D005260:Female; D005642:Fuchs' Endothelial Dystrophy / Q000453:epidemiology / Q000601:surgery; D006801:Humans; D007223:Infant; D007640:Keratoconus / Q000453:epidemiology / Q000601:surgery; D015948:Keratoplasty, Penetrating / Q000639:trends; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies