Benzimidazole CB2 agonists: design, synthesis and SAR.
A new series of CB2-selective agonists containing a benzimidazole core is reported. Design, synthesis, SAR and pharmacokinetic data for selected compounds are described.
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, United States. Electronic address: kausik_nanda@merck.com.
Kausik K
KK
Nanda
Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
Darrell A
DA
Henze
Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
Kimberly
K
Della Penna
Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
Reshma
R
Desai
Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
Michael
M
Leitl
Department of Pain Research, Merck Research Laboratories, West Point, PA, United States.
Wei
W
Lemaire
Department of Drug Metabolism & Pharmacokinetics, Merck Research Laboratories, West Point, PA, United States.
Rebecca B
RB
White
Department of Drug Metabolism & Pharmacokinetics, Merck Research Laboratories, West Point, PA, United States.
Suzie
S
Yeh
Department of Structure Elucidation, Merck Research Laboratories, West Point, PA, United States.
Janine N
JN
Brouillette
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, United States.
George D
GD
Hartman
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA, United States.
Mark T
MT
Bilodeau
Department of Medicinal Chemistry, Merck Research Laboratories, Boston, MA, United States.
B Wesley
BW
Trotter
D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists*; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; D043885:Receptor, Cannabinoid, CB2; C031000:benzimidazole
Benzimidazole; CB2 agonist; Cannabinoid 2 receptor