Early administration of terbutaline in severe pediatric asthma may reduce incidence of acute respiratory failure.
BACKGROUND
Severe pediatric asthma, if not immediately and aggressively treated, may progress to acute respiratory failure requiring mechanical ventilation in the pediatric intensive care unit (PICU). Intravenous (IV) terbutaline, a β2 agonist, is dispensed when the initial treatment does not improve the clinical condition.


OBJECTIVE
To investigate the influence of early initiation of IV terbutaline on the incidence of acute respiratory failure requiring mechanical ventilation in severe pediatric asthma.


METHODS
A retrospective chart review was conducted of 120 subjects (35 patients from an outside hospital emergency department [ED] with late start of terbutaline and 85 patients from the authors' hospital ED with early initiation of IV terbutaline) admitted to the PICU with severe asthma treated with continuous IV terbutaline. Responses to terbutaline treatment and outcomes were evaluated.


RESULTS
Patients transported from outlying hospital EDs had shorter pre-PICU mean durations of IV terbutaline than those transferred from the authors' ED (0.69 ± 1.38 and 2.91 ± 2.47 hours, respectively, P = .001). Twenty-one of 35 patients (60%) from outlying EDs required mechanical ventilation compared with 14 of 85 patients (16%) from the authors' ED (P = .001). Durations of pre-PICU terbutaline infusion for patients requiring mechanical ventilation were significantly shorter than those with no such requirement (P = .015).


CONCLUSIONS
The results of the present study, conducted in the largest number of subjects to date, suggest that early administration of continuous terbutaline in the ED may decrease acute respiratory failure and the need for mechanical respiratory (invasive and noninvasive) support in severe pediatric asthma.
Division of Pediatric Critical Care Medicine, Cohen Children's Medical Center of New York, New Hyde Park, New York. Electronic address: sdoymaz@hotmail.com.
Sule
S
Doymaz
Division of Pediatric Critical Care Medicine, Cohen Children's Medical Center of New York, New Hyde Park, New York.
James
J
Schneider
Division of Pediatric Critical Care Medicine, New York University Medical Center, New York, New York.
Mayer
M
Sagy
D058666:Adrenergic beta-2 Receptor Agonists / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D015278:Intensive Care Units, Pediatric; D008297:Male; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000453:epidemiology*; D012189:Retrospective Studies; D013726:Terbutaline / Q000008:administration & dosage*
D058666:Adrenergic beta-2 Receptor Agonists; D001993:Bronchodilator Agents; D013726:Terbutaline