AMPK-sensitive cellular transport.
The energy sensing AMP-activated protein kinase (AMPK) regulates cellular and whole-body energy balance through stimulating catabolic ATP-generating and suppressing anabolic ATP-consuming pathways thereby helping cells survive during energy depletion. The kinase has previously been reported to be either directly or indirectly involved in the regulation of several carriers, channels and pumps of high significance in cellular physiology. Thus AMPK provides a necessary link between cellular energy metabolism and cellular transport activity. Better understanding of the AMPK role in cellular transport offers a potential for improved therapies in various human diseases and disorders. In this review, we discuss recent advances in understanding the role and function of AMPK in transport regulation under physiological and pathological states.
Faculty of Medicine, University of Prishtina, Str. Bulevardi i Dëshmorëve, p.n. 10 000 Prishtina, Kosova; Department of Chemistry, University of Prishtina, Str. 'Nëna Terezë' p.n. 10 000 Prishtina, Kosova; Department of Chemistry, University of Tirana, Tirana, Albania; and Department of Biological and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 31, 98166 S.Agata-Messina, Italy.
Miribane
M
Dërmaku-Sopjani
Sokol
S
Abazi
Caterina
C
Faggio
Jehona
J
Kolgeci
Mentor
M
Sopjani
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008954:Models, Biological
D007473:Ion Channels; D055372:AMP-Activated Protein Kinases
AMPK; carrier; cellular transport; energy homeostasis; ion channel; pump