Integrin cytoplasmic tail interactions.
Integrins are heterodimeric cell surface adhesion receptors essential for multicellular life. They connect cells to the extracellular environment and transduce chemical and mechanical signals to and from the cell. Intracellular proteins that bind the integrin cytoplasmic tail regulate integrin engagement of extracellular ligands as well as integrin localization and trafficking. Cytoplasmic integrin-binding proteins also function downstream of integrins, mediating links to the cytoskeleton and to signaling cascades that impact cell motility, growth, and survival. Here, we review key integrin-interacting proteins and their roles in regulating integrin activity, localization, and signaling.
Department of Cell Biology and ‡Department of Pharmacology, Yale University School of Medicine , 333 Cedar Street, New Haven, Connecticut 06520, United States.
Elizabeth M
EM
Morse
Nina N
NN
Brahme
David A
DA
Calderwood
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D040542:Mechanotransduction, Cellular; D015398:Signal Transduction
D016023:Integrins; D047908:Intracellular Signaling Peptides and Proteins