Novel polyhydroxylated steroids from the East China Sea gorgonian Echinogorgia sassapo reticulata with suppressive activity of leukotriene C4 generation and degranulation in bone marrow-derived mast cells.
The gorgonian Echinogorgia sassapo reticulata contains two new bioactive polyhydroxylated steroids, sassapols A (1), B (2), and five related known compounds (3-7). Compound 6 has been encountered for the first time in natural sources. The structures of these new compounds were defined by spectroscopic analysis. All the compounds (1-7) isolated from E. sassapo reticulata were tested for anti-inflammatory activity. Compounds 1, 3, 5, and 7 inhibited both the generation of leukotriene C₄ and the degranulation reaction in mouse bone marrow-derived mast cells.
a Institute of Molecular Medicine, Huaqiao University , Quanzhou 362021 , China.
Rong
R
Xu
Mei-Hua
MH
Jin
Yang
Y
Jiao
Guo-Sheng
GS
Xing
Wen-Jun
WJ
Zhao
Chuan
C
Zhao
Hong-Quan
HQ
Duan
Sheng-An
SA
Tang
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells / Q000187:drug effects; D002681:China; D017997:Leukotriene C4 / Q000037:antagonists & inhibitors*; D008407:Mast Cells / Q000187:drug effects*; D051379:Mice; D015394:Molecular Structure; D009792:Oceans and Seas; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D013256:Steroids; D017997:Leukotriene C4