Coffee polyphenols improve peripheral endothelial function after glucose loading in healthy male adults.
Brewed coffee is a widely consumed beverage, and many studies have examined its effects on human health. We investigated the vascular effects of coffee polyphenols (CPPs), hypothesizing that a single ingestion of CPP during glucose loading would improve endothelial function. To test this hypothesis, we conducted a randomized acute clinical intervention study with crossover design and measured reactive hyperemia index (RHI) to assess the acute effects of a 75-g glucose load with CPP in healthy, nondiabetic adult men. Blood glucose and insulin levels were elevated after glucose loading with and without CPP, with no significant differences between treatments. The RHI did not significantly decrease after glucose loading without CPP. With CPP, however, RHI significantly (P < .05) increased over baseline after glucose loading. The difference between treatments was statistically significant (P < .05). No significant changes were observed in an oxidative stress marker after glucose loading with or without CPP. These findings suggest that a single ingestion of CPP improves peripheral endothelial function after glucose loading in healthy subjects.
Health Care Food Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan. Electronic address: ochiai.ryuuji@kao.co.jp.
Ryuji
R
Ochiai
Health Care Food Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Yoko
Y
Sugiura
Health Care Food Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Yasushi
Y
Shioya
Health Care Food Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Kazuhiro
K
Otsuka
Health Care Food Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
Yoshihisa
Y
Katsuragi
Department of Laboratory and Vascular Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, 890-8520, Japan.
Teruto
T
Hashiguchi
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D040503:Coffea / Q000737:chemistry*; D003069:Coffee / Q000737:chemistry*; D018592:Cross-Over Studies; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D006940:Hyperemia; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols / Q000494:pharmacology*; D012016:Reference Values
D001786:Blood Glucose; D003069:Coffee; D010936:Plant Extracts; D059808:Polyphenols; D005947:Glucose
3,4-diCQA; 3,4-dicaffeoylquinic acid; 3,5-diCQA; 3,5-dicaffeoylquinic acid; 3-CQA; 3-FQA; 3-caffeoylquinic acid; 3-feruloylquinic acid; 4,5-diCQA; 4,5-dicaffeoylquinic acid; 4-CQA; 4-FQA; 4-caffeoylquinic acid; 4-feruloylquinic acid; 5-CQA; 5-FQA; 5-caffeoylquinic acid; 5-feruloylquinic acid; BP; CPP; CQAs; Chlorogenic acid; Chlorogenic acids; Coffee; Endothelial function; FMD; Glu; Men; Polyphenol; RHI; ROS; blood pressure; coffee polyphenol; flow-mediated dilation; glucose; reactive hyperemia index; reactive oxygen species