[Evaluation of a long-term sensomotor deficit after neonatal rat brain ischemia/hypoxia].
The application of magnetic resonance imaging method showed that ischemia/hypoxia of the brain of neonatal rats made by the protocol suggested by Levine-Rice induces one-sided lesions in the areas of cerebral cortex, striatum and hippocampus. Unilateral ischemic injury leads to a long-term sensorimotor and behavioral distortions within 90-115 days after the operation which has been tested in animals by the battery of tests including Cylinder, Beam-walking, Staircase and Limb-placing test. Chosen battery of tests in combination with magnetic resonance imaging allows to reliably estimate the long-term sensorimotor recovery in adult animals suffered an injury in neonatal age.
D N
DN
Silachev
M I
MI
Shubina
S S
SS
Iankauskas
V P
VP
Mkrtchian
V N
VN
Manskikh
M V
MV
Guliaev
D B
DB
Zorov
D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000187:drug effects* / Q000293:injuries; D003342:Corpus Striatum / Q000473:pathology; D056228:Feedback, Sensory; D006624:Hippocampus / Q000187:drug effects / Q000473:pathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D051381:Rats