mRNA deadenylation by Pan2-Pan3.
Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3'→5' exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylation activity in eukaryotes: Ccr4-Not and Pan2-Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2-Pan3 deadenylation complex.
*MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, U.K.
Jana
J
Wolf
*MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, U.K.
Lori A
LA
Passmore
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D005095:Exoribonucleases / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D026723:Polyadenylation; D020871:RNA Stability; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*
D002352:Carrier Proteins; C568693:PAN3 protein, human; D012333:RNA, Messenger; D005095:Exoribonucleases; C551828:PAN2 protein, human