Air, bone and soft tissue excitation of the cochlea in the presence of severe impediments to ossicle and window mobility.
Clinical conditions have been described in which one of the two cochlear windows is immobile (otosclerosis) or absent (round window atresia), but nevertheless bone conduction (BC) thresholds are relatively unaffected. To clarify this apparent paradox, experimental manipulations which would severely impede several of the classical osseous mechanisms of BC were induced in fat sand rats, including discontinuity or immobilization of the ossicular chain, coupled with window fixation. Effects of these manipulations were assessed by recording auditory nerve brainstem evoked response (ABR) thresholds to stimulation by air conduction (AC), by osseous BC and by non-osseous BC (also called soft tissue conduction-STC) in which the BC bone vibrator is applied to skin sites. Following the immobilization, discontinuity and window fixation, auditory stimulation was also delivered to cerebro-spinal fluid (CSF) and to saline applied to the middle ear cavity. While the manipulations (immobilization, discontinuity, window fixation) led to an elevation of AC thresholds, nevertheless, there was no change in osseous and non-osseous BC thresholds. On the other hand, ABR could be elicited in response to fluid pressure stimulation to CSF and middle ear saline, even in the presence of the severe restriction of ossicular chain and window mobility. The results of these experiments in which osseous and non-osseous BC thresholds remained unchanged in the presence of severe restriction of the classical middle ear mechanisms and in the absence of an efficient release window, while ABR could be recorded in response to fluid pressure auditory stimulation to fluid sites, indicate that it is possible that the inner ear may be activated at low sound intensities by fast fluid pressure stimulation. At higher sound intensities, a slower passive basilar membrane traveling wave may serve to excite the inner ear.
Department of Otolaryngology and Head and Neck Surgery, Shaare Zedek Medical Center, POB 3235, 91031, Jerusalem, Israel.
Ronen
R
Perez
Speech and Hearing Center, Hebrew University School of Medicine-Hadassah Medical Center, POB 12000, 91120, Jerusalem, Israel.|Department of Communication Disorders, Hadassah Academic College, 37 Hanevi'im Street, POB 1114, 91010, Jerusalem, Israel.
Cahtia
C
Adelman
Department of Communication Disorders, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Shai
S
Chordekar
Department of Otolaryngology and Head and Neck Surgery, Western Galilee Hospital, Nahariya, Israel.
Reuven
R
Ishai
Department of Medical Neurobiology (Physiology), Institute for Medical Research-Israel-Canada, Hebrew University-Hadassah Medical School, POB 12272, 91120, Jerusalem, Israel. haims@ekmd.huji.ac.il.
Haim
H
Sohmer
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001489:Basilar Membrane / Q000473:pathology / Q000503:physiopathology; D001844:Bone Conduction / Q000502:physiology*; D015834:Cochlear Diseases / Q000151:congenital*; D004195:Disease Models, Animal; D004429:Ear Ossicles / Q000473:pathology / Q000503:physiopathology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D005849:Gerbillinae; D010040:Otosclerosis; D051381:Rats; D012405:Round Window, Ear / Q000473:pathology / Q000503:physiopathology