Vaccinium corymbosum L. (blueberry) extracts exhibit protective action against cadmium toxicity in Saccharomyces cerevisiae cells.
Blueberries (Vaccinium corymbosum L.) are a rich source of antioxidants and their consumption is believed to contribute to food-related protection against oxidative stress. In the present study, the chemoprotective action of blueberry extracts against cadmium toxicity was investigated using a cadmium-hypersensitive strain of Saccharomyces cerevisiae. Four varieties of blueberries were used in the study, and it was found that the extracts with high content of total anthocyanidins exhibited significant protective effect against the toxicity of cadmium and H2O2. Both the blueberry extracts and pure cyanidin exhibited protective effects against cadmium in a dose-dependent manner, but without significantly interfering with the cadmium accumulation by the yeast cells. The results imply that the blueberry extracts might be a potentially valuable food supplement for individuals exposed to high cadmium.
University of Bucharest, Faculty of Chemistry, Department of Organic Chemistry, Biochemistry and Catalysis, Sos. Panduri 90-92, 050663 Bucharest, Romania. Electronic address: eliza.oprea@g.unibuc.ro.
Eliza
E
Oprea
University of Bucharest, Faculty of Chemistry, Department of Organic Chemistry, Biochemistry and Catalysis, Sos. Panduri 90-92, 050663 Bucharest, Romania. Electronic address: lavinia.ruta@g.unibuc.ro.
Lavinia L
LL
Ruta
University of Bucharest, Faculty of Chemistry, Department of Organic Chemistry, Biochemistry and Catalysis, Sos. Panduri 90-92, 050663 Bucharest, Romania. Electronic address: ioanaa.dumitru@g.unibuc.ro.
Ioana
I
Nicolau
University of Bucharest, Faculty of Chemistry, Department of Organic Chemistry, Biochemistry and Catalysis, Sos. Panduri 90-92, 050663 Bucharest, Romania. Electronic address: claudia.popa@g.unibuc.ro.
Claudia V
CV
Popa
University of Bucharest, Faculty of Biology, Spl. Independentei 91-95, 050095 Bucharest, Romania. Electronic address: aurora.neagoe@unibuc.ro.
Aurora D
AD
Neagoe
University of Bucharest, Faculty of Chemistry, Department of Organic Chemistry, Biochemistry and Catalysis, Sos. Panduri 90-92, 050663 Bucharest, Romania. Electronic address: ileana.farcasanu@g.unibuc.ro.
Ileana C
IC
Farcasanu
D029798:Blueberry Plants / Q000737:chemistry*; D002104:Cadmium / Q000633:toxicity*; D005638:Fruit / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
D010936:Plant Extracts; D020011:Protective Agents; D002104:Cadmium; D006861:Hydrogen Peroxide
Cadmium; Cyanidin; Saccharomyces cerevisiae; Vaccinium corymbosum; YAP1