Antiplasmodial and cytotoxic dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv.
Two unusual dibenzofurans, preussiafurans A-B (1-2), together with six known compounds have been isolated from the fungus Preussia sp. occurring in Enantia chlorantha Oliv. The structures were established on the basis of 1D and 2D NMR spectroscopy and MS analysis. Compounds 1-4 showed antiplasmodial activity against erythrocytic stages of chloroquine-resistant Plasmodium falciparum (NF54) and moderate cytotoxicity on L6 cell lines with IC50 values of 8.67 and 14.8 μM, respectively.
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
Ferdinand Mouafo
FM
Talontsi
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany.
Marc
M
Lamshöft
Institute of Biology, University of Kassel, Heinrich-Plett-Strasse 40, D-34132 Kassel, Germany.
Clovis
C
Douanla-Meli
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany; Department of Chemistry, Higher Teachers' Training College, University of Yaoundé I, P. O. Box 47, Yaoundé, Cameroon.
Simeon Fogue
SF
Kouam
Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany. Electronic address: m.spiteller@infu.tu-dortmund.de.
Michael
M
Spiteller
D000818:Animals; D029061:Annonaceae / Q000382:microbiology*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification*; D001203:Ascomycota / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D002460:Cell Line; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D051381:Rats; D064210:Secondary Metabolism
D000962:Antimalarials; D001572:Benzofurans; C000595286:preussiafuran A; C000595287:preussiafuran B
Antiplasmodial activity; Cytotoxicity; Dibenzofurans; Enanthia chloranta Oliv; Endophyte; Preussia sp.