Total synthesis of (+)-grandiamide D, dasyclamide and gigantamide A from a Baylis-Hillman adduct: A unified biomimetic approach.
A unified strategy was followed for the synthesis of three putrescine bisamides, (+)-grandiamide D, dasyclamide and gigantamide A, isolated from leaves of Aglaia gigantea, by making use of a common synthetic intermediate prepared by the Baylis-Hillman reaction. Asymmetric synthesis of the natural (+)-grandiamide D was accomplished from camphor sultam.
School of Chemistry, Bharathidasan University, Tiruchirappalli, 620024, India.
Andivelu
A
Ilangovan
School of Chemistry, Bharathidasan University, Tiruchirappalli, 620024, India ; Syngene International Ltd., Bangalore, 560 099, India.
Shanmugasundar
S
Saravanakumar
(+)-grandiamide D; Baylis–Hillman reaction; dasyclamide; gigantamide A; natural products; putrescine bisamides