Treatment of pain in SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome.
SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome includes a variety of musculoskeletal disorders and associated skin conditions. Diagnosis can be difficult but should be considered in the differential in patients with lytic, sclerotic, or hyperostotic bone lesions and pain. Appropriate and prompt treatment, including use of nonsteroidal medications such as ibuprofen or naproxen, colchicine, corticosteroids, and bisphosphonates, and use of disease-modifying agents such as methotrexate, sulfasalazine and infliximab, can produce improvement of symptoms. Multidisciplinary care, including the disciplines of rheumatology and dermatology, should be considered.
Department of Neurosurgery, Division of Pain Management, West Virginia University School of Medicine, Morgantown, WV 26505(∗). Electronic address: kimc@wvuhealthcare.com.
Chong H
CH
Kim
Department of Anesthesiology, West Virginia University, Morgantown, WV(†).
Sarah
S
Kadhim
Department of Anesthesiology, West Virginia University, Morgantown, WV(‡).
Christina
C
Julien
D020083:Acquired Hyperostosis Syndrome / Q000150:complications / Q000175:diagnosis*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D059350:Chronic Pain / Q000188:drug therapy* / Q000209:etiology; D003692:Delayed-Action Preparations; D003951:Diagnostic Errors; D003952:Diagnostic Imaging; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D010348:Patient Care Team
D000701:Analgesics, Opioid; D003692:Delayed-Action Preparations; D005938:Glucocorticoids