Accuracy of direct genomic values for functional traits in Brown Swiss cattle.
In this study, direct genomic values for the functional traits general temperament, milking temperament, aggressiveness, rank order in herd, milking speed, udder depth, position of labia, and days to first heat in Brown Swiss dairy cattle were estimated based on ~777,000 (777 K) single nucleotide polymorphism (SNP) information from 1,126 animals. Accuracy of direct genomic values was assessed by a 5-fold cross-validation with 10 replicates. Correlations between deregressed proofs and direct genomic values were 0.63 for general temperament, 0.73 for milking temperament, 0.69 for aggressiveness, 0.65 for rank order in herd, 0.69 for milking speed, 0.71 for udder depth, 0.66 for position of labia, and 0.74 for days to first heat. Using the information of ~54,000 (54K) SNP led to only marginal deviations in the observed accuracy. Trying to predict the 20% youngest bulls led to correlations of 0.55, 0.77, 0.73, 0.55, 0.64, 0.59, 0.67, and 0.77, respectively, for the traits listed above. Using a novel method to estimate the accuracy of a direct genomic value (defined as correlation between direct genomic value and true breeding value and accounting for the correlation between direct genomic values and conventional breeding values) revealed accuracies of 0.37, 0.20, 0.19, 0.27, 0.48, 0.45, 0.36, and 0.12, respectively, for the traits listed above. These values are much smaller but probably also more realistic than accuracies based on correlations, given the heritabilities and samples sizes in this study. Annotation of the largest estimated SNP effects revealed 2 candidate genes affecting the traits general temperament and days to first heat.
Department of Animal Science, Animal Breeding and Genetics Group, Georg-August-Universität Göttingen, Albrecht-Thaer-Weg 3, 37075 Göttingen, Germany. Electronic address: mkramer@gwdg.de.
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Kramer
Department of Animal Science, Animal Breeding and Genetics Group, Georg-August-Universität Göttingen, Albrecht-Thaer-Weg 3, 37075 Göttingen, Germany.
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Erbe
Qualitas AG, Chamerstraße 56, 6300 Zug, Switzerland.
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Seefried
Qualitas AG, Chamerstraße 56, 6300 Zug, Switzerland.
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Gredler
Qualitas AG, Chamerstraße 56, 6300 Zug, Switzerland.
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Bapst
FiBL-Research Institute of Organic Agriculture, Ackerstrasse 21, 5070 Frick, Switzerland.
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Bieber
Department of Animal Science, Animal Breeding and Genetics Group, Georg-August-Universität Göttingen, Albrecht-Thaer-Weg 3, 37075 Göttingen, Germany.
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Simianer
D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics / Q000502:physiology*; D003612:Dairying; D005260:Female; D016678:Genome; D055106:Genome-Wide Association Study / Q000662:veterinary*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results; D013694:Temperament
accuracy of direct genomic value; direct genomic value prediction; functional trait; gene annotation