Ruthenium-catalyzed hydroarylation of anilides with alkynes: an efficient route to ortho-alkenylated anilines.
Acetanilides reacted with symmetrical as well as unsymmetrical alkynes in the presence of [{RuCl2(p-cymene)}2], pivalic acid, and AgSbF6 in iso-PrOH providing ortho-alkenylated acetanilides in a highly regio- and stereoselective manner. Later, ortho-alkenylated acetanilides were converted into ortho-alkenylated anilines in the presence of HCl.
Department of Chemistry, Indian Institute of Science Education and Research , Pune 411021, India.
Rajendran
R
Manikandan
Masilamani
M
Jeganmohan