Stromal reaction and prognosis in acinic cell carcinoma of the salivary gland.
BACKGROUND
Primary acinic cell carcinoma (ACC) is an uncommon malignant neoplasm of the salivary gland (SG), which usually presents as slow growing tumor.


METHODS
We reported a 69-year-old woman with tumor in the right parotid gland with a 5-year progress. Biopsy sections revealed a hybrid form of ACC with a low- and high-grade component and prominent lymphoid tissue in tumor stroma. Immunohistochemistry was performed to define the molecular profile of this unusual ACC, with special interest for stromal influence on to the proliferative activity of ACC with dedifferentiation. We detected that the level and the type of stromal lymphoid reaction (particularly CD8+/CD4+ ratio) had a significant influence on to Ki-67 index in the high-grade component of ACC, as well as the involvement of the CXCR4 signaling axis in the stromal reaction influence.


CONCLUSIONS
We suggest that tumor stroma may be a source of potential new tumor biomarkers which can determine the aggressivity of this tumor.
Institute of Pathology, Faculty of Medicine, University of Nis, Nis, Serbia.
Ljubinka Janković
LJ
Velicković
Department of Immunology, Faculty of Medicine, University of Nis, Nis, Serbia.
Irena
I
Dimov
Clinic of Stomatology, Faculty of Medicine, University of Nis, Nis, Serbia.
Dragan
D
Petrović
Institute of Pathology, Faculty of Medicine, University of Nis, Nis, Serbia.
Slavica
S
Stojnev
Clinic of Stomatology, Faculty of Medicine, University of Nis, Nis, Serbia.
Stefan
S
Dacić
Clinic of Stomatology, Faculty of Medicine, University of Nis, Nis, Serbia.
Stefan
S
Velicković
Institute of Nephrology, Faculty of Medicine, University of Nis, Nis, Serbia.
Vladisav
V
Stefanović
D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D018267:Carcinoma, Acinar Cell / Q000175:diagnosis* / Q000378:metabolism; D005260:Female; D006801:Humans; D010307:Parotid Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D011379:Prognosis; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology
D014408:Biomarkers, Tumor