Drug delivery system design and development for boron neutron capture therapy on cancer treatment.
We have already synthesized a boron-containing polymeric micellar drug delivery system for boron neutron capture therapy (BNCT). The synthesized diblock copolymer, boron-terminated copolymers (Bpin-PLA-PEOz), consisted of biodegradable poly(D,l-lactide) (PLA) block and water-soluble polyelectrolyte poly(2-ethyl-2-oxazoline) (PEOz) block, and a cap of pinacol boronate ester (Bpin). In this study, we have demonstrated that synthesized Bpin-PLA-PEOz micelle has great potential to be boron drug delivery system with preliminary evaluation of biocompatibility and boron content.
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC; Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC.
Lin-Chiang
LC
Sherlock Huang
Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu 31040, Taiwan, ROC.
Wen-Yuan
WY
Hsieh
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan, ROC.
Jiun-Yu
JY
Chen
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan, ROC.
Su-Chin
SC
Huang
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli 35053, Taiwan, ROC.
Jen-Kun
JK
Chen
Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC. Electronic address: mhhsu@mx.nthu.edu.tw.
Ming-Hua
MH
Hsu
D020341:Absorbable Implants; D001896:Boron Compounds / Q000008:administration & dosage / Q000737:chemistry* / Q000633:toxicity*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D002470:Cell Survival / Q000187:drug effects*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000633:toxicity; D004058:Diffusion; D015195:Drug Design; D006367:HeLa Cells; D006801:Humans; D019344:Lactic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D011108:Polymers / Q000737:chemistry* / Q000633:toxicity*
C510584:2,2'-bis(2-oxazoline) linked poly(lactic acid); C578864:4,4,5,5-tetramethyl(1,3,2)dioxaborolane; D001896:Boron Compounds; D003692:Delayed-Action Preparations; D011108:Polymers; D019344:Lactic Acid
BNCT; Drug delivery; Micelle; PEOz; PLA