Cardiovascular autonomic neuropathy in context of other complications of type 2 diabetes mellitus.
The aim of this study was to investigate the relationship between cardiac autonomic neuropathy (CAN) and other micro- and macrovascular complications and risk factors for type 2 diabetes. We included, in this study, 149 patients with type 2 diabetes. We evaluated their cardiovascular risk factors, demographic data, and any major micro- and macrovascular complications of their diabetes. Assessments of CAN were based upon Ewing's battery.


RESULTS
CAN was present in 38.9% of patients. In the CAN group, the duration of diabetes, BMI, systolic blood pressure, lipid levels, and HBA1c were all significantly higher than those in the other group. A significant association was found between CAN and retinopathy, peripheral neuropathy, ABI, and IMT. Multivariate logistic regression demonstrated that, in type 2 diabetes, the odds of CAN (OR (95% confidence intervals)) increase with the age of the patients (1.68 (1,4129-2.0025)), the average diabetes duration (0.57 (0.47-0.67)), cholesterol (1.009 (1.00-1.01)), HbA1c levels (1.88 (1.31-2.72)), peripheral neuropathy (15.47 (5.16-46.38)), BMI (1.12 (1.05-1.21)), and smoking (2.21 (1.08-4.53)).


CONCLUSIONS
This study shows that CAN in type 2 diabetes is significantly associated with other macro- and microvascular complications and that there are important modifiable risk factors for its development.
Department of Neurology, University of Medicine and Pharmacy Târgu Mureş, Târgu Mureş, Gheorghe Marinescu, No. 38, 540139, Romania ; Mureş County Clinical Emergency Hospital, Târgu Mureş, Gheorghe Marinescu, No. 50, 540136, Romania.
Anca
A
Moţăţăianu
Department of Neurology, University of Medicine and Pharmacy Târgu Mureş, Târgu Mureş, Gheorghe Marinescu, No. 38, 540139, Romania.
Rodica
R
Bălaşa
Department of Epidemiology, University of Medicine and Pharmacy Târgu Mureş, Târgu Mureş, Gheorghe Marinescu, No. 38, 540139, Romania.
Septimiu
S
Voidăzan
Department of Neurology, University of Medicine and Pharmacy Târgu Mureş, Târgu Mureş, Gheorghe Marinescu, No. 38, 540139, Romania.
Zoltán
Z
Bajkó
D000368:Aged; D015992:Body Mass Index; D018376:Cardiovascular Abnormalities / Q000150:complications / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000473:pathology*; D003929:Diabetic Neuropathies / Q000150:complications / Q000473:pathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000473:pathology; D012307:Risk Factors
D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human