Mechanism of O2 activation and methanol production by (di(2-pyridyl)methanesulfonate)Pt(II)Me(OH(n))((2-n)-) complex from theory with validation from experiment.
The mechanism of the (dpms)Pt(II)Me(OH(n))((2-n)-) oxidation in water to form (dpms)Pt(IV)Me(OH)2 and (dpms)Pt(IV)Me2(OH) complexes was analyzed using DFT calculations. At pH < 10, (dpms)Pt(II)Me(OH(n))((2-n)-) reacts with O2 to form a methyl Pt(IV)-OOH species with the methyl group trans to the pyridine nitrogen, which then reacts with (dpms)Pt(II)Me(OH(n))((2-n)-) to form 2 equiv of (dpms)Pt(IV)Me(OH)2, the major oxidation product. Both the O2 activation and the O-O bond cleavage are pH dependent. At higher pH, O-O cleavage is inhibited whereas the Pt-to-Pt methyl transfer is not slowed down, so making the latter reaction predominant at pH > 12. The pH-independent Pt-to-Pt methyl transfer involves the isomeric methyl Pt(IV)-OOH species with the methyl group trans to the sulfonate. This methyl Pt(IV)-OOH complex is more stable and more reactive in the Pt-to-Pt methyl-transfer reaction as compared to its isomer with the methyl group trans to the pyridine nitrogen. A similar structure-reactivity relationship is also observed for the S(N)2 functionalization to form methanol by two isomeric (dpms)Pt(IV)Me(OH)2 complexes, one featuring the methyl ligand trans to the sulfonate group and another with the methyl trans to the pyridine nitrogen. The barrier to functionalize the former isomer with the CH3 group trans to the sulfonate group is 2-9 kcal/mol lower. The possibility of the involvement of Pt(III) species in the reactions studied was found to correspond to high-barrier reactions and is hence not viable. It is concluded that the dpms ligand facilitates Pt(II) oxidation both enthalpically and entropically.
Materials and Process Simulation Center, California Institute of Technology , Pasadena, California 91125, United States.
Wei-Guang
WG
Liu
Anna V
AV
Sberegaeva
Robert J
RJ
Nielsen
William A
WA
Goddard
Andrei N
AN
Vedernikov