Predictive value of serum collagen biomakers on the outcome of acute myocardial infarction treated with percutaneous coronary intervention.
OBJECTIVE
This study was designed to investigate the predictive value of serum collagen biomarkers on the outcomes of acute ST-elevation myocardial infarction (STEMI) treated with percutaneous coronary intervention (PCI).


METHODS
Two hundred and ten patients with STEMI were successfully treated with PCI within 6 hrs ofthe onset of chest pain. The levels of serum procollagen type I carboxyterminal peptide (PICP) and procollagen type III peptide (PIIINP) were measured by enzymelinked immunosorbent assay (ELISA) before, 3 and 6 months after PCI. Left ventricular ejection fraction was assessed by echocardiography at 3 and 6 months after PCI. The composite endpoints were death by any cause, recurrent myocardial infarction, heart failure or stroke.


RESULTS
At the end of the 12-month follow up, 29 patients (13.8%) experienced an end point. The level of serum PICP in patients with an end point was higher than in patients without an end point 7 days (19.45 ± 2.17 vs 14.95 ± 3.07 ng/mL, P<0.05) or 3 month after the PCI (29.87 ± 3.02 vs 22.14 ± 3.33 ng/mL, P<0.05). The serum PIIINP level in patients with an end point was also higher than those without 7 days after PCI (59.34 ± 4.23 vs 48.78 ± 4.23 ng/mL, P<0.05). Multivariate logistic regression analysis showed day 7 (OR=2.170, 95% CI 1.583-4.345, P=0.01) and 3-month serum PICP (OR=2.340, 95% CI 1.431-4.650, P=0.01) were independent predictors of composite end points.


CONCLUSIONS
Persistent elevation of serum collagen marker PICP three months after PCI predicts an adverse outcome for patients with acute ST-elevation myocardial infarction.
Department of Cardiology, Liaocheng People's Hospital, Liaocheng 252000, PR China.
Hang
H
Gao
Department of Cardiology, Liaocheng People's Hospital, Liaocheng 252000, PR China.
Xue-Song
XS
Zhang
Department of Cardiology, the Red Cross Hospital of Guangzhou City, the Fourth Affiliated Hospital of Jinan University, Guangzhou 510220, PR China.
Qiang
Q
Zhao
Department of Cardiology, Liaocheng People's Hospital, Liaocheng 252000, PR China.|School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
Long-Le
LL
Ma
Department of Cardiology, Liaocheng People's Hospital, Liaocheng 252000, PR China.|School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, NSW 2678, Australia.
Le-Xin
LX
Wang
D000704:Analysis of Variance; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D010446:Peptide Fragments / Q000378:metabolism*; D062645:Percutaneous Coronary Intervention; D011347:Procollagen / Q000378:metabolism*; D012008:Recurrence; D013318:Stroke Volume / Q000502:physiology; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000209:etiology
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; C042813:procollagen type I carboxy terminal peptide
left ventricular function; myocardial infarction; percutaneous coronary intervention; procollagen type I carboxyterminal peptide