[Expression and significance of hMSH2 protein in laryngeal squamous cell carcinoma].
OBJECTIVE
To study the expression and significance of hMSH2 protein in laryngeal squamous cell carcinoma.


METHODS
The expression of hMSH2 protein were detected by immunohistochemistry SP method in 51 cases of laryngeal squamous cell carcinoma, the control group included 30 cases of atypical hyperplasia tissue of vocal fold and 16 cases of normal laryngeal tissue.


RESULTS
The expression rates of hMSH2 in laryngeal squamous cell carcinoma, atypical hyperplasia tissue of vocal fold and normal laryngeal tissue were 58.8%, 73.3%, 87.5% respectively. There was significant difference among them (P < 0. 05). The expression of hMSH2 in laryngeal carcinoma was not associated with location and T stage (P > 0.05), but the expression was related with metastasis of lymph node and differentiation level (P < 0.05).


CONCLUSIONS
The deletion of hMSH2 maybe participate the early occurrence of laryngeal carcinoma; hMSH2 protein maybe delay and suppress oncogenesis and development of laryngeal carcinoma.
Department of Otolaryngology-Head and Neck Surgery, the First Peoples' Hospital of Ping-dingshan, Pingdingshan, 467000, China. pdsrenyingchuan@126.com
Yingchuan
Y
Ren
Department of Otolaryngology-Head and Neck Surgery, the First Peoples' Hospital of Ping-dingshan, Pingdingshan, 467000, China.
Peiyan
P
Qi
Department of Otolaryngology-Head and Neck Surgery, the First Peoples' Hospital of Ping-dingshan, Pingdingshan, 467000, China.
Yuxia
Y
Li
Department of Otolaryngology-Head and Neck Surgery, the First Peoples' Hospital of Ping-dingshan, Pingdingshan, 467000, China.
Xiaosheng
X
Wang
Department of Otolaryngology-Head and Neck Surgery, the First Peoples' Hospital of Ping-dingshan, Pingdingshan, 467000, China.
Ying
Y
Du
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D051718:MutS Homolog 2 Protein / Q000378:metabolism*; D000077195:Squamous Cell Carcinoma of Head and Neck
C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein