In vivo optical spectroscopy for improved detection of pancreatic adenocarcinoma: a feasibility study.
Pancreatic adenocarcinoma has a five-year survival rate of less than 6%. This low survival rate is attributed to the lack of accurate detection methods, which limits diagnosis to late-stage disease. Here, an in vivo pilot study assesses the feasibility of optical spectroscopy to improve clinical detection of pancreatic adenocarcinoma. During surgery on 6 patients, we collected spectrally-resolved reflectance and fluorescence in vivo. Site-matched in vivo and ex vivo data agreed qualitatively and quantitatively. Quantified differences between adenocarcinoma and normal tissues in vivo were consistent with previous results from a large ex vivo data set. Thus, optical spectroscopy is a promising method for the improved diagnosis of pancreatic cancer in vivo.
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2099, USA.
William R
WR
Lloyd
Applied Physics Program, University of Michigan, Ann Arbor, MI 48109-1040, USA.
Robert H
RH
Wilson
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2099, USA.
Seung Yup
SY
Lee
Applied Physics Program, University of Michigan, Ann Arbor, MI 48109-1040, USA.
Malavika
M
Chandra
Department of Pathology, University of Michigan, Ann Arbor, MI 48109-0602, USA.
Barbara
B
McKenna
Department of Surgery, University of Michigan, Ann Arbor, MI 48109-5331, USA.
Diane
D
Simeone
Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109-0362, USA ; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109-0944, USA.
James
J
Scheiman
Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109-2099, USA ; Applied Physics Program, University of Michigan, Ann Arbor, MI 48109-1040, USA ; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109-0944, USA.
Mary-Ann
MA
Mycek
(170.3660) Light propagation in tissues; (170.4580) Optical diagnostics for medicine; (170.6510) Spectroscopy, tissue diagnostics