An efficient strategy for the synthesis of polysubstituted chromeno[4,3-b]pyrrolidine derivatives.
A powerful cascade reaction was developed for the synthesis of chromeno[4,3-b]pyrrolidines with high yields and excellent stereoselectivities. This efficient cascade reaction expeditiously established two fused rings which bear three contiguous stereogenic centers including one quaternary stereocenter in a single operation with low catalyst loading under mild conditions.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China. liangym@lzu.edu.cn xupf@lzu.edu.cn.
Li
L
Tian
Guo-Qiang
GQ
Xu
Yun-Han
YH
Li
Yong-Min
YM
Liang
Peng-Fei
PF
Xu
D007097:Imines / Q000737:chemistry; D007783:Lactones / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000737:chemistry
D007097:Imines; D007783:Lactones; D011759:Pyrrolidines; D013890:Thiourea