Ni(II)-salt catalyzed activation of primary amine-sp(3)Cα-H and cyclization with 1,2-diketone to tetrasubstituted imidazoles.
NiCl2·6H2O and Ni(OAc)2·4H2O were found as efficient catalysts for C-H activation of benzyl and aliphatic amines for an unprecedented multi C-N bond forming cyclization with 1,2-diketones under refluxing toluene to furnish highly substituted and polycyclic imidazoles.
Department of Chemistry, University of Calcutta, University College of Science, 92, A. P. C. Road, Kolkata-700009, India. dkmchem@caluniv.ac.in.
Srikanta
S
Samanta
Dipanwita
D
Roy
Saikat
S
Khamarui
Dilip K
DK
Maiti