Role of extracellular matrix signaling cues in modulating cell fate commitment for cardiovascular tissue engineering.
It is generally agreed that engineered cardiovascular tissues require cellular interactions with the local milieu. Within the microenvironment, the extracellular matrix (ECM) is an important support structure that provides dynamic signaling cues in part through its chemical, physical, and mechanical properties. In response to ECM factors, cells activate biochemical and mechanotransduction pathways that modulate their survival, growth, migration, differentiation, and function. This Review describes the role of ECM chemical composition, spatial patterning, and mechanical stimulation in the specification of cardiovascular lineages, with a focus on stem cell differentiation, direct transdifferentiation, and endothelial-to-mesenchymal transition. The translational application of ECMs is discussed in the context of cardiovascular tissue engineering and regenerative medicine.
Department of Cardiothoracic Surgery, Stanford University, 300 Pasteur Dr, Stanford, CA, 94305, USA; Cardiovascular Institute, Stanford University, 265 Campus Drive, G1120, MC-5454, Stanford, CA, 94305, USA; Veterans Affairs Palo Alto Health Care System, 3801 Miranda Avenue, Mail Code 153, Palo Alto, CA, 94304 60031l, 650-493-5000, USA.
Karina H
KH
Nakayama
Luqia
L
Hou
Ngan F
NF
Huang
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D044968:Regenerative Medicine / Q000379:methods*; D015398:Signal Transduction; D023822:Tissue Engineering / Q000379:methods*
cardiovascular; cell fate; extracellular matrix; stem cells; tissue engineering