Correlation of metabolic tumor volume and 11C-choline uptake with the pathology of prostate cancer: evaluation by use of simultaneously recorded MR and PET images.
OBJECTIVE
This study was conducted to assess the relationship between (11)C-choline uptake and pathologic findings obtained by combined use of magnetic resonance (MR) and positron emission tomography (PET) imaging of patients with prostate cancer.


METHODS
We retrospectively evaluated 69 patients with prostate cancer who underwent (11)C-choline PET-CT and magnetic resonance imaging before radical prostatectomy. Combined MR-PET images were acquired to obtain precise anatomic information. The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were compared with pathologic findings from resected specimens as the reference standard.


RESULTS
The mean and standard deviation of tumor SUVmax and MTV were 3.9 ± 1.8 and 12.9 ± 16.4, respectively. Tumors with high MTV (≧8.2) were more likely to be admixed with prostatic intraepithelial neoplasia (PIN) (p < 0.0001) or hyperplasia (p < 0.0001) in the background than those without these findings. Multiple regression analysis also revealed that the presence of hyperplasia (OR; 4.25, 95% CI 1.25-14.4, p = 0.02) and PIN (OR; 9.22, 95% CI 2.60-32.7, p = 0.001) were associated with tumors with high MTV.


CONCLUSIONS
We have demonstrated, by pathologic evaluation of patients with prostate cancer, that (11)C-choline uptake volume is greater for prostate cancer admixed with PIN and hyperplasia than that without.
Department of Radiology, Graduate School of Medicine, Yokohama City University, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan.
Tomohiro
T
Yoneyama
Ukihide
U
Tateishi
Takashi
T
Terauchi
Tomio
T
Inoue
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002250:Carbon Radioisotopes; D002794:Choline; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D047368:Tumor Burden
D002250:Carbon Radioisotopes; D002794:Choline