[Circadian rhythm and stroke].
Studies on the relationship between stroke incidence and alterations of circadian rhythm are scarce, while pathologically reduced or abolished circadian variation has been described to cause stroke since a long time ago. Although ischemic and hemorrhagic strokes are different entities and are characterized by different pathophysiological mechanisms, they share an identical pattern. A constellation of endogenous circadian rhythms and exogenous cyclic factors are involved. The staging of the circadian rhythms in vascular tone, coagulation balance including platelet function, and blood pressure plus temporal patterns in posture, physical activity, emotional stress, autonomic function, and medication effects play central and/or triggering roles. Features of the circadian rhythm of blood pressure, in terms of their chronic and acute effects on cerebral vessels, and of coagulation are especially important.
Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University.
Yasuo
Y
Terayama
D000818:Animals; D001794:Blood Pressure; D002545:Brain Ischemia / Q000209:etiology / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D012307:Risk Factors; D012890:Sleep; D020521:Stroke / Q000209:etiology / Q000503:physiopathology*