Fructose-bisphosphate aldolase a is a potential metastasis-associated marker of lung squamous cell carcinoma and promotes lung cell tumorigenesis and migration.
Fructose-bisphosphate aldolase A (ALDOA) is a key enzyme in glycolysis and is responsible for catalyzing the reversible conversion of fructose-1,6-bisphosphate to glyceraldehydes-3-phosphate and dihydroxyacetone phosphate. ALDOA contributes to various cellular functions such as muscle maintenance, regulation of cell shape and mobility, striated muscle contraction, actin filament organization and ATP biosynthetic process. Here, we reported that ALDOA is a highly expressed in lung squamous cell carcinoma (LSCC) and its expression level is correlated with LSCC metastasis, grades, differentiation status and poor prognosis. Depletion of ALDOA expression in the lung squamous carcinoma NCI-H520 cells reduces the capabilities of cell motility and tumorigenesis. These data suggest that ALDOA could be a potential marker for LSCC metastasis and a therapeutic target for drug development.
Department of Histology and Embryology, Dalian Medical University, Liaoning, China ; Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Liaoning, China.
Sha
S
Du
Department of Histology and Embryology, Dalian Medical University, Liaoning, China ; Liaoning Key Laboratory of Proteomics, Dalian Medical University, Liaoning, China.
Zhuzhu
Z
Guan
Department of Histology and Embryology, Dalian Medical University, Liaoning, China.
Lihong
L
Hao
Department of Histology and Embryology, Dalian Medical University, Liaoning, China.
Yang
Y
Song
Department of Histology and Embryology, Dalian Medical University, Liaoning, China.
Lan
L
Wang
Department of Histology and Embryology, Dalian Medical University, Liaoning, China.
Linlin
L
Gong
Department of Histology and Embryology, Dalian Medical University, Liaoning, China.
Lu
L
Liu
Department of Histology and Embryology, Dalian Medical University, Liaoning, China.
Xiaoyu
X
Qi
Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Liaoning, China.
Zhaoyuan
Z
Hou
Department of Histology and Embryology, Dalian Medical University, Liaoning, China ; Liaoning Key Laboratory of Proteomics, Dalian Medical University, Liaoning, China.
Shujuan
S
Shao
D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000401:mortality / Q000556:secondary; D045744:Cell Line, Tumor; D003593:Cytoplasm / Q000201:enzymology; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D008969:Molecular Sequence Data; D060787:Neoplasm Grading; D009368:Neoplasm Transplantation
D014408:Biomarkers, Tumor; D005634:Fructose-Bisphosphate Aldolase