[Acute monoblastic leukemia with MLL/AF9 rearrangement which developed 18 months after myeloid sarcoma onset].
We describe a 36-month-old boy with acute monoblastic leukemia (AMoL M5a) and mixed-lineage leukemia (MLL)-AF9 rearrangement. At 18 months of age, he presented with swelling on the back of his hand that was considered to be an inflammatory change, but no hematological abnormalities were found. However, blasts with MLL-AF9 rearrangement were detected in biopsied tissue taken at the time and in peripheral blood samples taken 18 months later. These findings indicate that myeloid sarcoma with MLL-AF9 rearrangement may ultimately, though slowly, progress to AMoL.
Department of Pediatrics, Dokkyo Medical University School of Medicine.
Yuya
Y
Sato
Atsuko
A
Nakazawa
Hidemitsu
H
Kurosawa
Keitaro
K
Fukushima
Mayuko
M
Okuya
Susumu
S
Hagisawa
Kenichi
K
Sugita
Osamu
O
Arisaka
D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001706:Biopsy / Q000379:methods; D002675:Child, Preschool; D015321:Gene Rearrangement / Q000235:genetics*; D006801:Humans; D007948:Leukemia, Monocytic, Acute / Q000209:etiology / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics / Q000378:metabolism; D012074:Remission Induction; D023981:Sarcoma, Myeloid / Q000150:complications / Q000235:genetics / Q000473:pathology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D051788:Myeloid-Lymphoid Leukemia Protein; C067980:CD68 antigen, human; D000097382:CD68 Molecule