[Research of grape seed powder on serum lipids and hepatic protection effects in high-fat diet rats].
OBJECTIVE
To research of grape seed powder on serum lipids and hepatic protection effects in high-fat diet rats.


METHODS
The rats were divided into five groups, every group wastaken high-fat diet except control group, the physiological saline was administered to the control group and the high-fat diet groups. The doses of grape seed power in low, middle and high groups were determined based on the 1x , 5x , and 10x standard human doses (20 mg/60 kg BW), respectively. The rats were orally given test sample respectively for 28 days, once a day. Observed the changes of erum lipids and live pathology.


RESULTS
Compared to the control group, the serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) were increased significantly (P < 0.05) and HDL-C markedly decreased (P < 0.05) in high-fat diet group. The histological data with light microscopy demonstrated that the fatty degeneration in liver was significantly attenuated in grape seed powder rats as compared to high-fat diet group.


CONCLUSIONS
The grape seed powder can reduce the level of serum lipids and prevent the occurrence of fatty liver.
Jilin Medical College, Jilin 132013, China. scmjilin@163.com
Chunmei
C
Song
Jilin Medical College, Jilin 132013, China.
Xiuhong
X
Zhong
Jilin Medical College, Jilin 132013, China.
Hongjuan
H
Ge
Jilin Medical College, Jilin 132013, China.
Min
M
Liu
D000818:Animals; D059305:Diet, High-Fat / Q000009:adverse effects*; D005234:Fatty Liver / Q000097:blood / Q000517:prevention & control*; D006949:Hyperlipidemias / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D027843:Vitis / Q000737:chemistry*
D008055:Lipids; D010936:Plant Extracts