The impact of rapid weight loss on oxidative stress markers and the expression of the metabolic syndrome in obese individuals.
OBJECTIVE
Obesity is linked with a state of increased oxidative stress, which plays an important role in the etiology of atherosclerosis and type 2 diabetes mellitus. The aim of our study was to evaluate the effect of rapid weight loss on oxidative stress markers in obese individuals with metabolic syndrome (MetS).


METHODS
We measured oxidative stress markers in 40 obese subjects with metabolic syndrome (MetS+), 40 obese subjects without metabolic syndrome (MetS-), and 20 lean controls (LC) at baseline and after three months of very low caloric diet.


RESULTS
Oxidized low density lipoprotein (ox-LDL) levels decreased by 12% in MetS+ subjects, associated with a reduction in total cholesterol (TC), even after adjustment for age and sex. Lipoprotein associated phospholipase A₂ (Lp-PLA₂) activity decreased by 4.7% in MetS+ subjects, associated with a drop in LDL-cholesterol (LDL-C), TC, and insulin levels. Multivariate logistic regression analysis showed that a model including ox-LDL, LpPLA₂ activity, and myeloperoxidase (MPO) improved prediction of MetS status among obese individuals compared to each oxidative stress marker alone.


CONCLUSIONS
Oxidative stress markers were predictive of MetS in obese subjects, suggesting a higher oxidative stress. Rapid weight loss resulted in a decline in oxidative stress markers, especially in MetS+ patients.
Centre for Preventive Cardiology, 3rd Department of Internal Medicine, General Teaching Hospital and Charles University in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.
Eva
E
Tumova
Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, and Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Wensheng
W
Sun
Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, and Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Peter H
PH
Jones
Centre for Preventive Cardiology, 3rd Department of Internal Medicine, General Teaching Hospital and Charles University in Prague, U Nemocnice 2, 128 08 Prague 2, Czech Republic.
Michal
M
Vrablik
Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, and Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Christie M
CM
Ballantyne
Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, and Section of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Ron C
RC
Hoogeveen
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D031204:Caloric Restriction; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007328:Insulin / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D018384:Oxidative Stress; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
D015415:Biomarkers; D008078:Cholesterol, LDL; D007328:Insulin; D008077:Lipoproteins, LDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein