Chronic myeloid leukemia in children and adolescents: A single center experience from Eastern India.
BACKGROUND
Chronic Myeloid Leukemia (CML) constitutes around 3% of leukemia in the children and adolescent age group.


OBJECTIVE
The aim of the study was to evaluate the characteristics at presentation and the treatment outcome of CML in the children and adolescent age group.


METHODS
Retrospective analysis was carried out at a single center in India.


METHODS
Thirteen patients (≤17 years) attending CML outdoor from April 2008 to August 2012 were included in the analysis.


METHODS
The mean and median of various parameters were calculated using a Microsoft excel sheet. SPSS 16.0 version software was used to calculate OS and PFS.


RESULTS
CML-CP was the most common phase at presentation. Maximum patients belonged to the 14 - 17 year old age group. Disease was common in the male sex. Splenic discomfort and asthenia were the most common symptoms and splenomegaly was the most common sign.


CONCLUSIONS
The treatment with Imatinib was effective and well-tolerated.
Institute of Hematology and Transfusion Medicine, Medical College and Hospital, Kolkata, West Bengal, India.
Lalit
L
Raut
Institute of Hematology and Transfusion Medicine, Medical College and Hospital, Kolkata, West Bengal, India.
Vinay V
VV
Bohara
Institute of Hematology and Transfusion Medicine, Medical College and Hospital, Kolkata, West Bengal, India.
Siddhartha S
SS
Ray
Institute of Hematology and Transfusion Medicine, Medical College and Hospital, Kolkata, West Bengal, India.
Prantar
P
Chakrabarti
Institute of Hematology and Transfusion Medicine, Medical College and Hospital, Kolkata, West Bengal, India.
Utpal
U
Chaudhuri
Children and adolescents; chronic myeloid leukemia; imatinib