PPAR α and PPAR γ polymorphisms as risk factors for dyslipidemia in a Chinese Han population.
BACKGROUND
The PPAR α and PPAR γ are the key messengers responsible for the translation of nutritional stimuli into changes for the expression of genes, particularly genes involved in lipid metabolism. However, the associations between PPAR α/γ polymorphisms and lipid serum levels in the general population were rarely studied, and the conclusions were conflicting. The objective was to investigate the associations of the PPAR α and PPAR γ polymorphisms with dyslipidemia.


METHODS
820 subjects were randomly selected from the Prevention of Multiple Metabolic Disorders and MS in Jiangsu Province cohort populations. The logistic regression model was used to examine the association between these polymorphisms and dyslipidemia. SNPstats was used to explore the haplotype association analyses.


RESULTS
In the codominant and log-additive models, rs1800206, rs1805192 and rs3856806 were all associated with dyslipidemia (P < 0.005). When the most common haplotype L-G (established by rs1800206, rs4253778) was treated as the reference group, the V-G haplotype was associated with dyslipidemia (P < 0.001), higher TC and TG levels (P < 0.01). Moreover, when compared to Pro-C haplotype (established by rs1805192, rs3856806), the Pro-T, Ala-C, Ala-T haplotypes were associated with dyslipidemia (p < 0.001). A-T haplotype was associated with higher TC levels, (p < 0.01), and the P-T, A-C, A-T haplotypes were associated with higher TG levels (p < 0.01).


CONCLUSIONS
PPAR α and PPAR γ polymorphisms and haplotypes may be the genetic risk factors for dyslipidemia.
Shu-Jun
SJ
Gu
Department of Epidemiology, School of Public Health, Soochow University, Suzhou, Jiangsu 215123, China. guozhirong28@163.com.
Zhi-Rong
ZR
Guo
Zheng-Yuan
ZY
Zhou
Xiao-Shu
XS
Hu
Ming
M
Wu
D000328:Adult; D016022:Case-Control Studies; D002681:China; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000097:blood / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D047493:PPAR alpha / Q000235:genetics; D047495:PPAR gamma / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D047493:PPAR alpha; D047495:PPAR gamma; D014280:Triglycerides; D002784:Cholesterol