The GG genotype of telomerase reverse transcriptase at genetic locus rs2736100 is associated with human atherosclerosis risk in the Han Chinese population.
A single nucleotide polymorphism (SNP) in the second intron of human TERT (hTERT), rs2736100, acts as a critical factor in hTERT synthesis and activation. The rs2736100 SNP was found to be associated with susceptibility to many cancers. Recently, inhibition of telomerase and marked telomere shortening were determined to be closely associated with the increasing severity of atherosclerosis. The association between the SNP of rs2736100 and the presence of atherosclerosis was evaluated in 84 atherosclerosis patients and 257 healthy controls using multivariate logistic regression analyses. The proportion of the GG genotype in atherosclerosis patients (17.9%) was significantly higher than in the control group (9.7%). Eight variables, including age, gender, cholesterol, high density lipoprotein, homocysteine, total bilirubin, indirect bilirubin, and rs2736100 GG genotype, were associated with atherosclerosis with odds ratios of 1.88, 2.11, 1.66, 0.23, 1.27, 1.29, 1.53, and 1.74, respectively, using multivariate logistic regression analyses. Homozygous GG was demonstrated to be associated with the presence of atherosclerosis in our population.
Department of Laboratory, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
Lei
L
Feng
Intensive Care Unit, People's Hospital of Yuxi City, Yuxi, Yunnan Province, China.
Shi-Yan
SY
Nian
Faculty of Medicine, Kunming University of Science and Technology, Kunming, Yunnan Province, China.
Jihong
J
Zhang
D000328:Adult; D000368:Aged; D044466:Asian People; D050197:Atherosclerosis / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D001663:Bilirubin / Q000097:blood; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D019098:Telomerase / Q000235:genetics*; D016615:Telomere; D059505:Telomere Homeostasis
D008075:Lipoproteins, HDL; D002784:Cholesterol; C509186:TERT protein, human; D019098:Telomerase; D001663:Bilirubin