Performance of Routine Helicobacter pylori Invasive Tests in Patients with Dyspepsia.
Background. This study was designed to compare the accuracy of three different invasive methods for the detection of Helicobacter pylori (H. pylori) infection in patients with dyspepsia. These tests included culture, histology, and the rapid urease test (CLO test). Methods. H. pylori infection was diagnosed prospectively in 246 untreated dyspeptic patients who underwent upper gastrointestinal endoscopy. The gold standard for H. pylori infection was based on a positive culture or both a positive histological examination and a CLO test. Results. H. pylori was diagnosed in 33.3% of the patients. The sensitivity, specificity, positive predictive value, negative predictive value, and overall accuracy were as follows: histology from the antrum (95.12; 95.12; 90.7; 97.5; 95.12%); histology from the antrum and corpus (95.12; 95.12; 90.7; 97.5; 95.12%); histology from the corpus (76.83; 96.95; 92.65; 89.33; 90.24%); culture (91.46; 100; 100; 95.91; 97.15%); a CLO test from the antrum and corpus (85.59; 100; 100; 93.71; 95.52%); a CLO test from the antrum (64.63; 100; 100; 84.97; 88.21%); a CLO test from the corpus (69.51; 100; 100; 96.77; 89.83%), respectively. Conclusions. Antral biopsy histology and culture are the best methods for the diagnosis of H. pylori infection in our cohort of patients with dyspepsia.
Liver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, Taiwan.
Hsi-Chang
HC
Lee
Liver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, Taiwan.
Ting-Chang
TC
Huang
Liver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, Taiwan.
Chin-Lin
CL
Lin
Liver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, Taiwan.
Kuan-Yang
KY
Chen
Liver Center, Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei 106, Taiwan.
Chung-Kwe
CK
Wang
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan ; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Deng-Chyang
DC
Wu