IGFBP-3 promoter polymorphism -202A>C (rs2854774) contributes to prostate cancer risk: evidence based on 9,482 subjects.
OBJECTIVE
Evidence suggests that insulin-like growth factor-binding protein 3 (IGFBP-3) might play a role in the carcinogenesis of prostate cancer (PCa). To date, several studies have been conducted to investigate the association between IGFBP-3 -202A>C polymorphism and PCa risk in humans. However, the results remain inconclusive and inconsistent. Hence, we performed a meta-analysis of all eligible case-control studies.


METHODS
We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.


RESULTS
16 studies from 10 articles that included a total of 4,602 PCa cases and 4,880 controls were included in the meta-analysis. The results showed that the IGFBP-3 -A>C polymorphism was associated with a significant increase in PCa risk. The variant homozygote genotype CC of IGFBP-3 -202A>C polymorphism was associated with a significantly increased risk in homozygote comparison (OR = 1.22, 95% CI = 1.07-1.38, I(2) = 36.10%) and recessive model (OR = 1.11, 95% CI = 1.00-1.22, I(2) = 15.60%). In the stratified analysis, the risk remained for studies in Asian men and hospital-based studies.


CONCLUSIONS
These results suggested that the IGFBP-3 -202A>C polymorphism might contribute to PCa susceptibility, especially in Asian men and hospital-based studies. Further studies are needed to confirm the relationship.
Department of Urology, The Changshu Hospital Affiliated to Soochow University, Changshu, China.
Qi
Q
Ding
Ying
Y
Shi
Bo
B
Fan
Zhijiang
Z
Fan
Jing
J
Wang
D044466:Asian People; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*
C515497:IGFBP3 protein, human; D018972:Insulin-Like Growth Factor Binding Protein 3