Adult mesenchymal stem cells and their potency in the cell-based therapy.
Recent advances in the field of regenerative medicines manifested the unique properties of stem cells including the ability of self-renewal and differentiation to make them available for their replacement in tissue injury. Mesenchymal stem cells (MSCs) are important tools in treating immune disorders and in tissue repair due to their multipotency, immunosuppressive properties, and production of cytokines or growth factors. MSC-mediated therapy is a fast-growing field that has proven safe and effective in the treatment of various degenerative diseases and tissue injuries. Generation of induced pluripotent stem (iPS) cells holds a great promise for regenerative medicine and other aspects of clinical applications. The mechanisms governing multipotency in MSCs are not well understood. This review mainly throws light on the biology of MSCs, including their efficiency in treating several diseases and also the progress of the use of iPSC-derived MSC widely in the clinic.
Department of Virology and Immunology, Haffkine Institute, Parel, Mumbai, India.
Madhurima
M
Das
Department of Virology and Immunology, Haffkine Institute, Parel, Mumbai, India.
Inger Birgitta
IB
Sundell
Department of Virology and Immunology, Haffkine Institute, Parel, Mumbai, India.
Prasad S
PS
Koka
D000328:Adult; D053687:Adult Stem Cells / Q000276:immunology / Q000502:physiology* / Q000637:transplantation*; D000818:Animals; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000276:immunology / Q000502:physiology*; D044968:Regenerative Medicine / Q000379:methods / Q000639:trends; D014181:Transplantation Immunology / Q000502:physiology; D016896:Treatment Outcome