Diffuse renal parenchyma uptake with bone scintigraphy in a patient with paroxysmal nocturnal hemoglobinuria and normal kidney function.
A 41-year-old woman with a Harrington spondylodesis presented with lower back pain. Bone scintigraphy showed diffusely increased parenchymal uptake in both kidneys. She reported 2 previous periods of dark, almost black, urine. Additional flow cytometric analysis confirmed the diagnosis of paroxysmal nocturnal hemoglobinuria. The increased renal parenchyma uptake is very probably due to paroxysmal nocturnal hemoglobinuria-related renal hemosiderosis. Remarkably, the patient did not develop any abnormality of renal function.
From the Departments of *Nuclear Medicine, †Hematology, and ‡Nephrology, Medical Center Leeuwarden, Leeuwarden, the Netherlands.
Hans
H
Balink
Mels
M
Hoogendoorn
Marc
M
Hemmelder
D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D007677:Kidney Function Tests; D011877:Radionuclide Imaging