Cystic lymphoid hyperplasia of the parotid gland as the initial manifestation of HIV infection.
We report the case of a patient who presented with cystic lymphoid hyperplasia of the right parotid gland as the index diagnosis of HIV infection. Histological examination of the excised parotid gland revealed a solid-cystic lymphoepithelial lesion with a non-keratinous squamous epithelium, which grew into the lymphoid component via anastomosing cords and islands. These anastomosing cords and islands contained variably abundant B cells, several subepithelial multinucleated histiocytes, salivary ducts infiltrated by small lymphocytes, and a dense lymphoid infiltrate containing lymphoid follicles with enlarged, irregular germinal centres.
Department of Pathology, National University Health System, 5 Lower Kent Ridge Road, Singapore 119074. fredrikpetersson@live.se.
Bingcheng
B
Wu
Raymond
R
Ngo
Fredrik
F
Petersson
D000328:Adult; D001402:B-Lymphocytes / Q000166:cytology; D001706:Biopsy; D004847:Epithelial Cells / Q000166:cytology; D004848:Epithelium / Q000378:metabolism; D015658:HIV Infections / Q000175:diagnosis*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology* / Q000821:virology; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D010306:Parotid Gland / Q000473:pathology* / Q000821:virology; D012469:Salivary Glands / Q000473:pathology; D014057:Tomography, X-Ray Computed