Resolving human object recognition in space and time.
A comprehensive picture of object processing in the human brain requires combining both spatial and temporal information about brain activity. Here we acquired human magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI) responses to 92 object images. Multivariate pattern classification applied to MEG revealed the time course of object processing: whereas individual images were discriminated by visual representations early, ordinate and superordinate category levels emerged relatively late. Using representational similarity analysis, we combined human fMRI and MEG to show content-specific correspondence between early MEG responses and primary visual cortex (V1), and later MEG responses and inferior temporal (IT) cortex. We identified transient and persistent neural activities during object processing with sources in V1 and IT. Finally, we correlated human MEG signals to single-unit responses in monkey IT. Together, our findings provide an integrated space- and time-resolved view of human object categorization during the first few hundred milliseconds of vision.
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Radoslaw Martin
RM
Cichy
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Dimitrios
D
Pantazis
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Aude
A
Oliva
D000328:Adult; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004567:Electrodes, Implanted; D055724:Electrophysiological Phenomena; D005260:Female; D059907:Functional Neuroimaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008253:Macaca mulatta; D015225:Magnetoencephalography / Q000295:instrumentation / Q000379:methods*; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology / Q000601:surgery; D013997:Time Factors; D014793:Visual Cortex / Q000502:physiology; D055815:Young Adult