Cutaneous infection with Alternaria triticina in a Bilateral lung transplant recipient.
We report the case of a 60-year-old man who was receiving immunosuppressive therapy for a bilateral lung transplant and presented with a crusted, violaceous plaque on the left hand. Based on histopathology and microbiological culture the patient was diagnosed with infection by Alternaria species. Treatment with itraconazole led to complete resolution of the skin lesion. Forty months later he developed four reddish, nodular, skin lesions on the left leg. Analysis of a biopsy from one of these lesions using histopathologic and molecular techniques identified a mold that shared 98% homology with a strain of Alternaria triticina. Alternaria species belong to a group of dematiaceous fungi that cause opportunistic infections in humans. The incidence of these infections is increasing, mainly in transplant centers. To the best of our knowledge, this is the first reported case of a human infection caused by A. triticina.
Departamento de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria e IFIMAV, Santander, Spain.
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MC
González-Vela
Servicio de Dermatología, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain.
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S
Armesto
Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
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F
Unda-Villafuerte
Departamento de Anatomía Patológica, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria e IFIMAV, Santander, Spain. Electronic address: apavbj@humv.es.
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JF
Val-Bernal
D060487:Alternariosis / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000188:drug therapy
Alternaria triticina; Alternariosis cutánea; Cutaneous alternariosis; Feohifomicosis; Organ transplantation; Phaehyphomycoses; Trasplante de órganos