Association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and Graves' disease risk: a meta-analysis of 11 case-control studies.
BACKGROUND
Data on the association between the interleukin-1 (IL-1) gene polymorphisms and Graves' disease (GD) risk were conflicting. A meta-analysis was undertaken to assess this association.


METHODS
We searched for case-control studies investigating the association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk. We extracted data using standardized forms and calculated odds ratios (OR) with 95% confidence intervals (CI).


RESULTS
A total of 11 case-control studies were included in this meta-analysis. Available data indicated that the IL1B (-511) polymorphism was associated with GD risk in the overall populations (Caucasians and Asians) in homozygote model (TT vs. CC, OR = 0.86, 95% CI: 0.76-0.97, Pz  = 0.015), but not in dominant and recessive models (TT+TC vs. CC: OR = 0.95, 95% CI: 0.81-1.12, Pz  =  0.553 and TT vs. TC+CC: OR = 0.82, 95% CI: 0.60-1.12, Pz  =  0.205, respectively). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was found in the overall populations in any of the genetic models. In subgroup analyses according to ethnicity, the IL1B (-511) polymorphism was associated with GD risk in Asians in recessive and homozygote models (TT vs. TC+CC: OR =  0.68, 95% CI: 0.55-0.84, Pz < 0.001 and TT vs. CC: OR = 0.81, 95% CI: 0.70-0.93, Pz  =  0.003, respectively), but not in dominant model (TT+TC vs. CC: OR =  0.92, 95% CI: 0.77-1.11, Pz  =  0.389). No association between the IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk was indicated in Asians, and we found no association between the IL1B (-511), IL1B (+3954), IL1RN (VNTR) polymorphisms and GD risk in Caucasians in any of the genetic models.


CONCLUSIONS
The IL1B (-511) polymorphism, but not the IL1B (+3954) and IL1RN (VNTR) polymorphisms was associated with GD risk in Asians. There was no association between these polymorphisms and GD risk in Caucasians.
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Min-Li
ML
Chen
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Ning
N
Liao
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Hua
H
Zhao
Department of Clinical Medicine, Grade 2001, Guangxi Medical University, Nanning, China.
Jian
J
Huang
Department of Geriatrics and Gerontology, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
Zheng-Fu
ZF
Xie
D016022:Case-Control Studies; D005808:Genes, Recessive; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006111:Graves Disease / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics*; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
C508585:IL1B protein, human; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta