Mechanistic Studies of Azaphilic versus Carbophilic Activation by Gold(I) in the Gold/Palladium Dual-Catalyzed Rearrangement of Alkenyl Vinyl Aziridines.
A vinyl aziridine activation strategy cocatalyzed by palladium(0) and a gold(I) Lewis acid has been developed. This rearrangement installs a C-C and a C-N bond in one synthetic step to form pyrrolizidine and indolizidine products. Two proposed mechanistic roles for the gold cocatalyst were considered: (1) carbophilic gold catalysis or (2) azaphilic gold catalysis. Mechanistic studies support an azaphilic Lewis acid activation of the aziridine over a carbophilic Lewis acid activation of the alkene.
Department of Chemistry, University of California, Irvine, CA 92697-2025, USA.
Joshua J
JJ
Hirner
Department of Chemistry, University of California, Irvine, CA 92697-2025, USA.
Katrina E
KE
Roth
Department of Chemistry, University of California, Irvine, CA 92697-2025, USA.
Yili
Y
Shi
Department of Chemistry, University of California, Irvine, CA 92697-2025, USA.
Suzanne A
SA
Blum