[Research of the glomerular filtration rate estimation model].
The glomerular filtration rate (GFR) is an important index of renal function with advantages of accurate, sensitive, stable, repetitive and accurate measurement of renal functions. The GFR is mainly determined in the clear rate of radioisotope markers (99m)Tc-DTPA, the process of which is complicated, long time-taking, high cost, and radioactively injuring. Recently, the methods using other renal function parameters measured easily to create the mathematic models and to estimate GFR are being investigated in the world. In this paper, for the renal function data of the Chinese, the efficiency in the three existing GFR formulas has been optimized with multi-function optimization techniques and the accuracy of the computation has been improved. Then the BP neural network technology is used for establishing a new GFR formula, which is a simpler form and obtains higher precision result than the formulas existed. The rmse and P30 of the new formula are better than those of the old ones.
Jiangsu Province Hospital, Nanjing 210029, China.
Weihongt
W
Zhao
Jiangsu Province Hospital, Nanjing 210029, China.
Xiaohua
X
Pei
School of Computer Science and Technology, Nanjing University of Science and Technology, Nanjing 210094, China.
Dong
D
Li
School of Computer Science and Technology, Nanjing University of Science and Technology, Nanjing 210094, China.
Jin
J
Zhu
D000465:Algorithms; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood; D005919:Glomerular Filtration Rate; D006801:Humans; D008962:Models, Theoretical; D016571:Neural Networks, Computer; D016284:Technetium Tc 99m Pentetate
D055316:Cystatin C; D003404:Creatinine; D016284:Technetium Tc 99m Pentetate