Core fucosylation and IgG function in NAIT.
In this issue of Blood, Kapur et al show that maternal human platelet-specific antigen 1a (HPA 1a)-specific antibodies causing neonatal alloimmune thrombocytopenia (NAIT) possess oligosaccharides that are deficient in "core fucose" residues and appear to be more effective than fucosylated antibodies in promoting phagocytosis of antibody-coated platelets.
BLOODCENTER OF WISCONSIN;
Richard H
RH
Aster
D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000737:chemistry*; D007074:Immunoglobulin G / Q000737:chemistry*; D007518:Isoantibodies / Q000737:chemistry*; D011247:Pregnancy; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000097:blood* / Q000276:immunology*
D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007518:Isoantibodies