Molecular genetics of soft-tissue sarcomas: a brief overview for clinical oncologists.
Soft-tissue sarcomas (STSs) are a heterogeneous group of tumors with distinct lines of differentiation and biologic behavior. Currently, histological analysis is still the main diagnostic approach for the classification of STSs. However, ancillary molecular genetic methods are becoming increasingly important for diagnostic confirmation and therapeutic considerations. Herein, we provide a brief overview of clinically relevant molecular abnormalities of STSs for the general clinical oncologist.
From the *Department of Laboratory Medicine and Pathology, †Division of Medical Oncology, and ‡Department of Orthopedics, Mayo Clinic, Rochester, MN.
Jorge
J
Torres-Mora
Karen J
KJ
Fritchie
Steven I
SI
Robinson
Andre M
AM
Oliveira
D006801:Humans; D008967:Molecular Biology; D012509:Sarcoma / Q000235:genetics* / Q000473:pathology