Transient neonatal zinc deficiency due to a new autosomal dominant mutation in gene SLC30A2 (ZnT-2).
Transient neonatal zinc deficiency (TNZD) has a clinical presentation similar to that of acrodermatitis enteropathica but is caused by a low zinc concentration in maternal breast milk. TNZD becomes clinically evident during breastfeeding and is resolved by weaning and the introduction of complementary nutrition. We present a 4-month-old girl with TNZD due to a new autosomal dominant mutation (663delC) in the maternal SLC30A2 gene not previously described in the literature.
Department of Dermatology, Hospital Materno-Infantil, Complejo Hospitalario Carlos Haya, Málaga, Spain.
Miguel
M
Lova Navarro
Angel
A
Vera Casaño
Carmen
C
Benito López
María D
MD
Fernández Ballesteros
Daniel J
DJ
Godoy Díaz
Antonio
A
Crespo Erchiga
Santiago
S
Romero Brufau
D027682:Cation Transport Proteins / Q000235:genetics*; D005260:Female; D006130:Growth Disorders; D006801:Humans; D007223:Infant; D008664:Metal Metabolism, Inborn Errors / Q000188:drug therapy / Q000235:genetics*; D008895:Milk, Human / Q000737:chemistry; D009154:Mutation; D015032:Zinc / Q000627:therapeutic use / Q000172:deficiency
D027682:Cation Transport Proteins; C486299:SLC30A2 protein, human; D015032:Zinc