Withanolides from Physalis hispida.
Nine new withanolides (1-9), withahisolides A-I, were isolated along with nine known compounds (10-18) from the aerial parts of Physalis hispida. The structures of 1-9 were elucidated through a variety of spectroscopic techniques, while the structures of 1 and 2 were confirmed by X-ray crystallographic analysis. Compounds 1-3 are the first withanolides with nonaromatic six-membered ring D moieties. In addition, withanolide 8 represents a novel withanolide skeleton due to the absence of a C-13-C-17 bond within the steroidal nucleus.
Department of Medicinal Chemistry, University of Kansas , Lawrence, Kansas 66045, United States.
Cong-Mei
CM
Cao
Huaping
H
Zhang
Robert J
RJ
Gallagher
Victor W
VW
Day
Kelly
K
Kindscher
Patrick
P
Grogan
Mark S
MS
Cohen
Barbara N
BN
Timmermann
D018360:Crystallography, X-Ray; D007615:Kansas; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D032321:Physalis / Q000737:chemistry*; D054358:Withanolides / Q000737:chemistry / Q000302:isolation & purification*
D054358:Withanolides