Probiotics for human lactational mastitis.
The use of culture-dependent and -independent techniques to study the human milk microbiota and microbiome has revealed a complex ecosystem with a much greater diversity than previously anticipated. The potential role of the milk microbiome appears to have implications not only for short- and long-term infant health but also for mammary health. In fact, mammary disbiosis, which may be triggered by a variety of host, microbial and medical factors, often leads to acute, subacute or subclinical mastitis, a condition that represents the first medical cause for undesired weaning. Multiresistance to antibiotics, together with formation of biofilms and mechanisms for evasion of the host immune response, is a common feature among the bacterial agents involved. This explains why this condition uses to be elusive to antibiotic therapy and why the development of new strategies for mastitis management based on probiotics is particularly appealing. In fact, selected lactobacilli strains isolated from breast milk have already shown a high efficacy for treatment.
Department of Nutrition, Food Science and Food Technology, Complutense University of Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain Probisearch SL, C/ Santiago Grisolía 2, 28760 Tres Cantos, Spain.
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Fernández
Department of Nutrition, Food Science and Food Technology, Complutense University of Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain.
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Arroyo
Probisearch SL, C/ Santiago Grisolía 2, 28760 Tres Cantos, Spain.
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Espinosa
Department of Nutrition, Food Science and Food Technology, Complutense University of Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain.
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Marín
Department of Nutrition, Food Science and Food Technology, Complutense University of Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain.
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Jiménez
Department of Nutrition, Food Science and Food Technology, Complutense University of Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain Probisearch SL, C/ Santiago Grisolía 2, 28760 Tres Cantos, Spain.
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Rodríguez
D005260:Female; D006801:Humans; D008413:Mastitis / Q000628:therapy*; D008895:Milk, Human / Q000382:microbiology; D019936:Probiotics / Q000627:therapeutic use*; D016896:Treatment Outcome
breastfeeding; human milk; mastitis; microbiota; probiotics