Direct access to functionalized azepanes by cross-coupling with α-halo eneformamides.
The synthesis of functionalized azepanes was accomplished through the palladium-mediated cross-coupling of α-halo eneformamides with mostly unactivated nucleophiles under mild conditions. Alkenylations proceeded with excellent stereoselectivitiy. In most cases, high yields of the coupling products were obtained.
Department of Chemistry, University of California , Berkeley, California 94720, United States.
Timothy K
TK
Beng
Sidney M
SM
Wilkerson-Hill
Richmond
R
Sarpong
D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D005559:Formamides / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D001381:Azepines; D005559:Formamides; D010165:Palladium