Therapeutic angiogenesis after ischemic stroke: Chinese medicines, bone marrow stromal cells (BMSCs) and their combinational treatment.
Ischemic stroke is a clinical acute disease which causes neurological dysfunction and threatens a patient's life. Because the mechanism of pathology is complicated and most patients miss the best therapeutic window time, the effect of the treatment is not satisfied at present. Numerous studies indicated new vessels not only recuperated blood flow in the ischemic boundary zone, but also facilitated endogenous neurogenesis and improved neurological function after ischemic stroke. Therefore, angiogenesis has been an important research field in neurovascular regeneration. Recently, some Chinese medicines, bone marrow stromal cells (BMSCs) and their combination treatment were demonstrated to have beneficial effects in promoting angiogenesis both in vitro and in vivo. In this review, we summarized the effective mechanisms of Chinese medicines and BMSCs, as well as BMSCs in combination with Chinese medicines on angiogenesis post-stroke.
State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macao 999078, Macao SAR of P. R. China.
Qian
Q
Zhang
Yong-Hua
YH
Zhao
D064591:Allografts; D000818:Animals; D016026:Bone Marrow Transplantation; D001921:Brain / Q000502:physiology*; D003131:Combined Modality Therapy; D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D036145:Ginsenosides; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology; D057888:Iridoid Glucosides; D018919:Neovascularization, Physiologic; D009416:Nerve Regeneration; D055495:Neurogenesis; D052250:Nitric Oxide Synthase Type III; D008517:Phytotherapy; D020521:Stroke / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy*; D042461:Vascular Endothelial Growth Factor A
D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D051793:Hypoxia-Inducible Factor 1; D057888:Iridoid Glucosides; D042461:Vascular Endothelial Growth Factor A; C004999:ferulic acid; D052250:Nitric Oxide Synthase Type III; C035054:ginsenoside Rg1