The effects of age at the onset of drinking to intoxication and chronic ethanol self-administration in male rhesus macaques.
BACKGROUND
Consumption of alcohol begins during late adolescence in a majority of humans, and the greatest drinking occurs at 18-25 years then decreases with age.


OBJECTIVE
The present study measured the differences in ethanol intake in relation to age at the onset of ethanol access among nonhuman primates to control for self-selection in humans and isolate age effects on heavy drinking.


METHODS
Male rhesus macaques were assigned first access to ethanol during late adolescence (n = 8), young adulthood (n = 8), or early middle age (n = 11). The monkeys were induced to drink ethanol (4 % w/v in water) in increasing doses (water then 0.5, 1.0, 1.5 g/kg ethanol) using a fixed-time (FT) 300-s schedule of food delivery, followed by 22 h/day concurrent access to ethanol and water for 12 months. Age-matched controls consumed isocaloric maltose-dextrin solution yoked to the late adolescents expected to be rapidly maturing (n = 4).


RESULTS
Young adult monkeys had the greatest daily ethanol intake and blood-ethanol concentration (BEC). Only late adolescents escalated their intake (ethanol, not water) during the second compared to the first 6 months of access. On average, plasma testosterone level was consistent with age differences in maturation and tended to increase throughout the experiment more for control than ethanol-drinking adolescent monkeys.


CONCLUSIONS
Young adulthood in nonhuman primates strongly disposes toward heavy drinking, which is independent of sociocultural factors present in humans. Ethanol drinking to intoxication during the critical period of late adolescence is associated with escalation to heavy drinking.
Division of Neuroscience, Oregon National Primate Research Center, 505 NW 185th Avenue, Beaverton, OR, 97006, USA.
Christa M
CM
Helms
Andrew
A
Rau
Jessica
J
Shaw
Cara
C
Stull
Steven W
SW
Gonzales
Kathleen A
KA
Grant
D017668:Age of Onset; D000428:Alcohol Drinking / Q000503:physiopathology*; D000435:Alcoholic Intoxication / Q000503:physiopathology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000097:blood; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D060766:Drinking Water / Q000008:administration & dosage; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D012646:Self Administration; D013739:Testosterone / Q000097:blood; D014867:Water / Q000008:administration & dosage
D002492:Central Nervous System Depressants; D060766:Drinking Water; D014867:Water; D000431:Ethanol; D013739:Testosterone