Preventing UV induced cell damage by scavenging reactive oxygen species with enzyme-mimic Au-Pt nanocomposites.
We have prepared enzyme-mimic Au-Pt nanocomposites (NCs) for catalyzing the decomposition of reactive oxygen species. After surface modification, the Au-Pt NCs can be readily internalized and retained by human skin cells and also can effectively reduce cellular oxidative stress. We have demonstrated that the active and biocompatible Au-Pt nanocomposites can be applied for preventing cell damages by scavenging cellular reactive oxygen species induced by ultraviolet irradiation, indicating potential uses for the prevention and therapy of ROS-mediated diseases.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology Hunan University, Changsha 410082, China.
Bin
B
Xiong
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology Hunan University, Changsha 410082, China.
Ruili
R
Xu
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology Hunan University, Changsha 410082, China.
Rui
R
Zhou
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology Hunan University, Changsha 410082, China. Electronic address: yanhe2021@gmail.com.
Yan
Y
He
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology Hunan University, Changsha 410082, China.
Edward S
ES
Yeung
D002460:Cell Line; D016166:Free Radical Scavengers / Q000737:chemistry / Q000627:therapeutic use*; D006046:Gold / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry / Q000627:therapeutic use* / Q000648:ultrastructure; D010084:Oxidation-Reduction / Q000187:drug effects / Q000528:radiation effects; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D010984:Platinum / Q000737:chemistry / Q000627:therapeutic use*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D014466:Ultraviolet Rays
D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D010984:Platinum; D006046:Gold
Cell imaging; Enzyme-mimic nanomaterials; Reactive active species; Ultraviolet irradiation