Robust ZnO nanoparticle embedded memory device using vancomycin conjugate and its biorecognition for electrical charging node.
Conjugation of antibiotic vancomycin (VAN) on nanoparticles (NPs) has recently initiated novel works in the nanobiotechnology field. In this study, a bioelectronic structure using VAN conjugated zinc oxide (ZnO) NPs as charge storing elements on metal-pentacene-insulator-silicon (MPIS) device is demonstrated. Highly specific molecular recognition between the VAN and membrane protein unit mimicked from VAN-resistant bacteria is employed as the formation mechanism of self-assembly monolayers (SAMs) of ZnO NPs. The insulator surface is modified with the VAN cognate peptide of L-Ala-D-Glu-L-Lys-D-Ala-D-Ala by chemical activator coupling. Hysteretic behaviors in capacitance versus voltage (C-V) curves are obtained for the charged ZnO NPs exhibiting flatband voltage shifts, which demonstrate the charge storage on the VAN conjugated ZnO NPs. The potential perspective of this study will be a tangible progress of biomolecular electronics implemented by the interface between biomolecules and electronics.
Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea.
Minkeun
M
Kim
Department of Chemical and Biochemical Engineering, Korea University, Seoul 100-715, Republic of Korea.
Hye-Jin
HJ
Lee
Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea.
Sewook
S
Oh
Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea.
Yejin
Y
Kim
Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea.
Hunsang
H
Jung
Department of Chemical and Biochemical Engineering, Korea University, Seoul 100-715, Republic of Korea.
Min-Kyu
MK
Oh
Department of Chemistry, Ewha Womans's University, Seoul 120-750, Republic of Korea.
Yeo Joon
YJ
Yoon
Department of Molecular Science and Technology, Ajou University, Suwon 443-749, Republic of Korea.
Tae Hyeon
TH
Yoo
Department of Material Science and Engineering, Myongji University, Yongin 449-728, Republic of Korea.
Tae-Sik
TS
Yoon
Department of Chemical Engineering, Myongji University, Yongin 449-728, Republic of Korea. Electronic address: hyunho@mju.ac.kr.
Hyun Ho
HH
Lee
D000595:Amino Acid Sequence; D015374:Biosensing Techniques / Q000295:instrumentation*; D025802:Electric Capacitance; D004566:Electrodes; D004581:Electronics; D004867:Equipment Design; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010455:Peptides / Q000737:chemistry; D012666:Semiconductors; D014640:Vancomycin / Q000737:chemistry*; D015034:Zinc Oxide / Q000737:chemistry*
D010455:Peptides; D014640:Vancomycin; D015034:Zinc Oxide
Bioelectronics; Biorecognition; Memory device; Self-assembly monolayer; Vancomycin; ZnO nanoparticles