Effect of total-body prehabilitation on postoperative outcomes: a systematic review and meta-analysis.
OBJECTIVE
To systematically review the evidence of pre-operative exercise, known as 'prehabilitation', on peri- and postoperative outcomes in adult surgical populations.


METHODS
Systematic review and meta-analysis.


METHODS
CENTRAL, Medline, EMBASE, CINAHL, PsycINFO and PEDro were searched from 1950 to 2011.


METHODS
Two reviewers independently examined relevant, English-language articles that examined the effects of pre-operative total-body exercise with peri- and postoperative outcome analysis. Given the nascence of this field, controlled and uncontrolled trials were included. Risk of bias was assessed using the Cochrane Risk of Bias Assessment tool. Only data on length of stay were considered eligible for meta-analysis due to the heterogeneity of measures and methodologies for assessing other outcomes.


RESULTS
In total, 4597 citations were identified by the search strategy, of which 21 studies were included. Trials were generally small (median=54 participants) and of moderate to poor methodological quality. Compared with standard care, the majority of studies found that total-body prehabilitation improved postoperative pain, length of stay and physical function, but it was not consistently effective in improving health-related quality of life or aerobic fitness in the studies that examined these outcomes. The meta-analysis indicated that prehabilitation reduced postoperative length of stay with a small to moderate effect size (Hedges' g=-0.39, P=0.033). Intervention-related adverse events were reported in two of 669 exercising participants.


CONCLUSIONS
The literature provides early evidence that prehabilitation may reduce length of stay and possibly provide postoperative physical benefits. Cautious interpretation of these findings is warranted given modest methodological quality and significant risk of bias.
Department of Surgical Oncology, Princess Margaret Cancer Center, Toronto, Ontario, Canada; Kinesiology Program, University of Guelph-Humber, Toronto, Ontario, Canada; School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada. Electronic address: Daniel.santamina@guelphhumber.ca.
D
D
Santa Mina
University of Toronto, Toronto, Ontario, Canada; University Health Network, Toronto, Ontario, Canada.
H
H
Clarke
Kinesiology Program, University of Guelph-Humber, Toronto, Ontario, Canada; Cancer Care Ontario, Toronto, Ontario, Canada.
P
P
Ritvo
University of Toronto, Toronto, Ontario, Canada; University Health Network, Toronto, Ontario, Canada.
Y W
YW
Leung
Department of Surgical Oncology, Princess Margaret Cancer Center, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.
A G
AG
Matthew
School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada; University Health Network, Toronto, Ontario, Canada.
J
J
Katz
Department of Surgical Oncology, Princess Margaret Cancer Center, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada.
J
J
Trachtenberg
University of Toronto, Toronto, Ontario, Canada; University Health Network, Toronto, Ontario, Canada.
S M H
SM
Alibhai
D015444:Exercise / Q000502:physiology*; D006801:Humans; D026741:Physical Therapy Modalities; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care; D011788:Quality of Life
Exercise; General surgery; Meta-analysis; Postoperative outcomes; Postoperative period; Pre-operative exercise; Prehabilitation; Preoperative care; Preoperative period; Rehabilitation; Systematic review