Catalytic asymmetric conjugate addition of terminal alkynes to β-trifluoromethyl α,β-enones.
The first enantioselective conjugate alkynylation of β-trifluoromethyl α,β-enones using terminal alkynes and a taniaphos-Cu(I) complex as catalyst is described. Ketones bearing a trifluoromethylated propargylic chiral centre in the β-position were obtained with good yields and high enantiomeric excesses (up to 99%).
Departament de Química Orgànica, Facultat de Química, Universitat de València, C/ Dr. Moliner 50, 46100-Burjassot, Spain. jose.r.pedro@uv.es gonzalo.blay@uv.es.
Amparo
A
Sanz-Marco
Andrea
A
García-Ortiz
Gonzalo
G
Blay
José R
JR
Pedro
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000480:Alkynes; D006845:Hydrocarbons, Fluorinated; D007659:Ketones