Lipocalin-type prostaglandin D synthase is not a biomarker of atherosclerotic manifestations.
OBJECTIVE
Over the last decades Lipocalin-type prostaglandin D synthase (L-PGDS), Osteoprotegerin (OPG), Osteopontin (OPN) and Pregnancy associated plasma protein A (PAPP-A) have been reported to be associated with coronary artery disease, and L-PGDS has been proposed as a potential new diagnostic tool in the setting of stable coronary artery disease. We set out to investigate if measurement of concentrations of these biomarkers could be used to differentiate between four groups of individuals with different atherosclerotic manifestations.


METHODS
A total of 120 individuals from four equal gender- and age-matched groups were studied: (i) no previous cardiovascular disease (CVD) and no coronary calcifications [CAC-negative group], (ii) no previous CVD but evidence of severe coronary calcifications [CAC-positive group], (iii) acute coronary syndrome [ACS-group], and (iv) clinical stable patients with CVD, who were referred for cardiovascular surgery [CVD-group]. Concentrations of L-PGDS, OPG, OPN and PAPP-A were analyzed and compared between the four groups.


RESULTS
We did not find any significant differences in L-PGDS concentrations between the four groups (p = 0.32). OPG concentrations differed significantly (p = 0.003), with the highest concentration observed in ACS patients. Considering OPN (p = 0.12) and PAPP-A (p = 0.53) their concentrations between groups did not differ significantly.


CONCLUSIONS
The main message from this study is the observation that L-PGDS based on a single blood test appears to be less valuable than previously proposed in identification of patients with coronary artery disease. However, ACS patients have higher OPG concentrations than patients with different manifestations of stable atherosclerosis. Neither OPN nor PAPP-A concentrations differed between groups.
Department of Cardiology, Odense University Hospital , Odense , Denmark.
Susanne E
SE
Hosbond
Axel C P
AC
Diederichsen
Lise
L
Pedersen
Lars M
LM
Rasmussen
Henrik
H
Munkholm
Oke
O
Gerke
Tina S
TS
Poulsen
Hans
H
Mickley
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000097:blood; D054834:Lipocalins / Q000097:blood; D008297:Male; D008875:Middle Aged; D053495:Osteopontin / Q000097:blood; D053244:Osteoprotegerin / Q000097:blood*; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism; D061205:Vascular Calcification / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology
D015415:Biomarkers; D054834:Lipocalins; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human; D053495:Osteopontin; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase