Fine-coarse semantic processing in schizophrenia: a reversed pattern of hemispheric dominance.
Left lateralization for language processing is a feature of neurotypical brains. In individuals with schizophrenia, lack of left lateralization is associated with the language impairments manifested in this population. Beeman׳s fine-coarse semantic coding model asserts left hemisphere specialization in fine (i.e., conventionalized) semantic coding and right hemisphere specialization in coarse (i.e., non-conventionalized) semantic coding. Applying this model to schizophrenia would suggest that language impairments in this population are a result of greater reliance on coarse semantic coding. We investigated this hypothesis and examined whether a reversed pattern of hemispheric involvement in fine-coarse semantic coding along the time course of activation could be detected in individuals with schizophrenia. Seventeen individuals with schizophrenia and 30 neurotypical participants were presented with two word expressions of four types: literal, conventional metaphoric, unrelated (exemplars of fine semantic coding) and novel metaphoric (an exemplar of coarse semantic coding). Expressions were separated by either a short (250 ms) or long (750 ms) delay. Findings indicate that whereas during novel metaphor processing, controls displayed a left hemisphere advantage at 250 ms delay and right hemisphere advantage at 750 ms, individuals with schizophrenia displayed the opposite. For conventional metaphoric and unrelated expressions, controls showed left hemisphere advantage across times, while individuals with schizophrenia showed a right hemisphere advantage. Furthermore, whereas individuals with schizophrenia were less accurate than control at judging literal, conventional metaphoric and unrelated expressions they were more accurate when judging novel metaphors. Results suggest that individuals with schizophrenia display a reversed pattern of lateralization for semantic coding which causes them to rely more heavily on coarse semantic coding. Thus, for individuals with schizophrenia, speech situation are always non-conventional, compelling them to constantly seek for meanings and prejudicing them toward novel or atypical speech acts. This, in turn, may disadvantage them in conventionalized communication and result in language impairment.
Department of Psychology and Gonda Brain Research Center, Bar-Ilan University, Ramat Gan 52900, Israel.
Maor
M
Zeev-Wolf
Department of Psychology and Gonda Brain Research Center, Bar-Ilan University, Ramat Gan 52900, Israel. Electronic address: goldsa@mail.biu.ac.il.
Abraham
A
Goldstein
Emotion-Cognition Research Center, The Shalvata Mental Health Care Center and Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Yechiel
Y
Levkovitz
Department of Psychology and Gonda Brain Research Center, Bar-Ilan University, Ramat Gan 52900, Israel.
Miriam
M
Faust
D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D012660:Semantics; D012930:Social Dominance; D014825:Vocabulary; D055815:Young Adult
Hemispheres; Metaphor comprehension; Schizophrenia; Semantic processing; Split-visual field