Polychlorinated dioxins, furans (PCDD/Fs), and polychlorinated biphenyls (PCBs) and their trends in Canadian human milk from 1992 to 2005.
More than 300 samples of human milk were collected from individuals residing in various regions across Canada in the years 1992 to 2005. The milks were taken from the main populated areas east to west in southern Canada as well as from the region of Nunavik in northern Quebec and analysed for polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs). The concentrations, expressed in ng kg(-1) milk lipid, show an overall decrease of virtually all compounds examined including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), World Health Organization 2005 toxic equivalents (WHO2005-TEQ) PCDD/PCDFs, WHO2005-TEQ dioxin-like PCBs (dl-PCBs), and total PCBs. Median values of 2,3,7,8-TCDD changed from about 1.5 ng kg(-1) milk lipid in 1992 to 0.8 ng kg(-1) in 2005 while the median WHO2005-TEQ PCDD/F fell from about 14-7 ng kg(-1) milk lipid in the same period. The concentrations of PCDD/Fs and PCBs in samples from Nunavik, which is in Arctic Quebec, were higher than those observed in milk from southern Quebec although this difference was not large. Over two time periods, milk samples from Hamilton, Ontario showed slightly higher levels of PCBs than Austin, Texas, USA--a North American city of similar size and development but with more than twice the PBDE exposure. When compared with earlier human milk data going back to the early 1980s, this large data set shows a steady decline of human exposure to POPs in Canada by a factor of about four times.
Bureau Chemical Safety, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada. Electronic address: jake.ryan@hc-sc.gc.ca.
John Jake
JJ
Ryan
Bureau Chemical Safety, Health Products and Food Branch, Health Canada, Ottawa, ON, Canada.
Dorothea F K
DF
Rawn
D000328:Adult; D000818:Animals; D001572:Benzofurans / Q000032:analysis*; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins / Q000032:analysis*; D005260:Female; D005663:Furans / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008895:Milk, Human / Q000737:chemistry*; D009864:Ontario; D011078:Polychlorinated Biphenyls / Q000032:analysis*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis; D011792:Quebec; D013997:Time Factors; D014944:World Health Organization
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D005663:Furans; D008055:Lipids; D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls; C020887:dibenzo(1,4)dioxin
Human milk; PCBs; PCDD/PCDFs; Trends; WHO2005-TEQ