[Correlation between endothelin receptor type A gene polymorphism and sporadic intracranial aneurysms].
OBJECTIVE
To investigate the relationship between the 3 polymorphic loci of endothelin receptor type A (EDNRA) gene and intracranial aneurysms.


METHODS
Three EDNRA gene polymorphisms (rs5335, rs6842241, and rs6841581) were genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis. The genotype and allele frequencies were calculated in the patients and the control group to analyze the association between the gene and the size of aneurysms.


RESULTS
No significant difference was found in the distribution of the EDNRA gene genotypes or allele frequencies between the patients and the control subjects. Only GG genotype of rs6841581 was found to significantly correlate with the size of aneurysms.


CONCLUSIONS
EDNRA gene rs6841581 has significant associations with the size of intracranial aneurysms, indicating a possible role of EDNRA in the genetic mechanisms of intracranial aneurysms and subarachnoid hemorrhage.
Department of Neurology, General Hospital of PLA, Beijing 100853, China. E-mail: snkjyb40207@sina.cn.
Li
L
Liu
Xusheng
X
Huang
Yiling
Y
Cai
Kai
K
Feng
Juan
J
DU
Haojun
H
Lu
Feifei
F
Cheng
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D002532:Intracranial Aneurysm / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044022:Receptor, Endothelin A / Q000235:genetics*
D044022:Receptor, Endothelin A