[Effect of prenatal stress and 17beta-estradiol on anxiety and depressive behaviors of ovariectomized female rats].
The present study evaluated the ability of 17beta-estradiol to induce anxiolytic- and antidepressant-like action in adult ovariectomized female offspring of dams that were restrained under lights for 1 h on gestational days 15-19. There were no differences in behavioral profile of ovariectomized prenatal stressed and control female rats. Injections of 17beta-estradiol (0.5 microg/rat) in the course of two week had minimal behavioral effects in control rats, but produced a decrease of immobility in the forced swimming test and anxiety level in the elevated plus maze in prenatal stressed rats. These findings suggest that ovariectomized prenatal stressed female rats demonstrate more sensitivity to estrogen-replacement.
N E
NE
Ordian
S G
SG
Pivina
V K
VK
Akulova
V V
VV
Rakitskaia
D000328:Adult; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001007:Anxiety / Q000188:drug therapy* / Q000473:pathology; D001522:Behavior, Animal / Q000187:drug effects; D003863:Depression / Q000188:drug therapy* / Q000473:pathology; D004958:Estradiol / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D010052:Ovariectomy; D051381:Rats
D014151:Anti-Anxiety Agents; D004958:Estradiol