Genetic programs controlling cortical interneuron fate.
The origins of cortical interneurons in rodents have been localized to the embryonic subcortical telencephalon where distinct neuroepithelial precursors generate defined interneuron subsets. A swathe of research activity aimed at identifying molecular determinants of subtype identity has uncovered a number of transcription factors that function at different stages of interneuron development. Pathways that lead to the acquisition of mature interneuron traits are therefore beginning to emerge. As genetic programs are influenced by external factors the search continues not only into genetic determinants but also extrinsic influences and the interplay between the two in cell fate specification.
Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. Electronic address: n.tekki-kessaris@ucl.ac.uk.
Nicoletta
N
Kessaris
Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Lorenza
L
Magno
Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Anna Noren
AN
Rubin
Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK.
Marcio Guiomar
MG
Oliveira
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D002540:Cerebral Cortex / Q000166:cytology* / Q000196:embryology / Q000254:growth & development; D055614:Genetic Phenomena / Q000502:physiology*; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D014157:Transcription Factors