[Effect of mutations in lawc/Trf2 gene on development of chromocenter and chromosome disjunction in Drosophila melanogaster].
In Drosophila, one of the genes of the lawc/Trf2 (leg-arista-wing complex/TBP-related factor 2) complex encodes an alternative basic transcription factor homologous to the TRF2 protein in vertebrates and human and belongs to a conservative Tbp (TATA box-binding protein) gene family. In the present study, reasons for the high frequency of chromosome nondisjunction were studied among descendants of mutants from 18 lines with a decreased expression of the TRF2 protein. It was determined that the suppression of the TRF2 expression violates the development of a compact chromocenter and the correct approach of homologous chromosomes (in germinative and somatic cells). The possibility of the participation of TRF2 in the evolutionary genetically programmed process of sex-ratio violation, which is typical of a number of animal species, is discussed.
Yu E
YE
Vorontsova
R O
RO
Cherezov
O B
OB
Simonova
D000818:Animals; D059006:Chromosomes, Insect / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics* / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D005854:Germ Cells / Q000378:metabolism; D006570:Heterochromatin / Q000235:genetics / Q000378:metabolism*; D008297:Male; D009154:Mutation; D009630:Nondisjunction, Genetic; D012744:Sex Ratio; D035341:Telomeric Repeat Binding Protein 2 / Q000235:genetics* / Q000378:metabolism
D029721:Drosophila Proteins; D006570:Heterochromatin; C509085:TRF2 protein, Drosophila; D035341:Telomeric Repeat Binding Protein 2