One-pot synthesis of high fluorescent carbon nanoparticles and their applications as probes for detection of tetracyclines.
Herein, a novel strategy for synthesizing fluorescent carbon nanoparticles (CPs) with a quantum yield of approximately 7.1% has been well established by mixing l-cysteine, diphosphorus pentoxide and water. Compared with other current protocols, the method described here displayed various advantages including friendly manipulations, low cost, and rapid reactions. Subsequently, we applied the CPs prepared here for detections of tetracyclines (TCs). Briefly, the fluorescence intensity of CPs was quenched once TCs were introduced. Based on this phenomenon, TCs were analyzed respectively accompanyed with satisfactory detection limits and linear ranges. Significantly, the practicability of this sensing method was further validated by assaying TC in human urine samples and pharmaceutical preparations, confirming its potential to broaden avenues for detecting TCs. Additionally, the CPs could serve as fluorescent powder and ink followed by a simple post-treatment, suggesting their promising applications.
College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China. Electronic address: ming4444@swu.edu.cn.
Xiaoming
X
Yang
College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Yawen
Y
Luo
College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Shanshan
S
Zhu
College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Yuanjiao
Y
Feng
College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Yan
Y
Zhuo
College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China.
Yao
Y
Dou
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000652:urine*; D002244:Carbon / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D055772:Green Chemistry Technology; D006801:Humans; D057230:Limit of Detection; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D013050:Spectrometry, Fluorescence / Q000379:methods; D013754:Tetracyclines / Q000032:analysis* / Q000652:urine*
D000900:Anti-Bacterial Agents; D005456:Fluorescent Dyes; D013754:Tetracyclines; D002244:Carbon
Carbon nanoparticles; Fluorescence quenching.; One-pot synthesis; Tetracyclines