Alterations in hair follicle dynamics in women.
Endocrine changes supervening after parturition and menopause participate in the control of sebum production and hair growth modulation. The ensuing conditions include some peculiar aspects of hair loss (effluvium), alopecia, and facial hirsutism. The hair cycling is of major clinical relevance because most hair growth disorders result from disturbances in this chronobiological feature. Of note, any correlation between a biologic abnormality and hair cycling disturbance does not prove a relationship of causality. The proportion of postmenopausal women is rising in the overall population. Therefore, the prevalence of these hair follicle disturbances is globally on the rise. Current therapies aim at correcting the underlying hormonal imbalances, and at improving the overall cosmetic appearance. However, in absence of pathogenic diagnosis and causality criteria, chances are low that a treatment given by the whims of fate will adequately control hair effluvium. The risk and frequency of therapeutic inertia are further increased. When the hair loss is not controlled and/or compensated by growth of new hairs, several clinical aspects of alopecia inexorably develop. Currently, there is little evidence supporting any specific treatment for these endocrine hair disorders in post-partum and postmenopausal women. Current hair treatment strategies are symptomatic and nonspecific so current researchers aim at developing new, targeted methods.
Department of Dermatopathology, Unilab Lg, University Hospital of Liège, CHU Sart Tilman, 4000 Liège, Belgium ; Department of Dermatology, Regional Hospital of Huy, 4500 Huy, Belgium.
Claudine
C
Piérard-Franchimont
Department of Dermatopathology, Unilab Lg, University Hospital of Liège, CHU Sart Tilman, 4000 Liège, Belgium ; Laboratory of Skin Bioengineering and Imaging, Department of Clinical Sciences, B23, University of Liège, 4000 Liège, Belgium.
Gérald E
GE
Piérard
D000505:Alopecia / Q000473:pathology*; D005260:Female; D006197:Hair / Q000254:growth & development / Q000473:pathology*; D006201:Hair Diseases / Q000473:pathology*; D018859:Hair Follicle / Q000254:growth & development / Q000473:pathology*; D006801:Humans; D008593:Menopause / Q000378:metabolism / Q000502:physiology; D012629:Sebum / Q000378:metabolism