Identification of an arylalkylamine N-acyltransferase from Drosophila melanogaster that catalyzes the formation of long-chain N-acylserotonins.
Arylalkylamine N-acyltransferase-like 2(2) (AANATL2) from Drosophila melanogaster was expressed and shown to catalyze the formation of long-chain N-acylserotonins and N-acydopamines. Subsequent identification of endogenous amounts of N-acylserotonins and colocalization of these fatty acid amides and AANATL2 transcripts gives supporting evidence that AANATL2 has a role in the biosynthetic formation of these important cell signalling lipids.
Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Daniel R
DR
Dempsey
Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Kristen A
KA
Jeffries
Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Ryan L
RL
Anderson
Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Anne-Marie
AM
Carpenter
Department of Chemistry, University of South Florida, Tampa, FL 33620, USA.
Santiago
S
Rodriquez Opsina
Department of Chemistry, University of South Florida, Tampa, FL 33620, USA. Electronic address: merkler@usf.edu.
David J
DJ
Merkler
D000217:Acyltransferases / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D055162:Biocatalysis; D004331:Drosophila melanogaster / Q000201:enzymology* / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D009928:Organ Specificity; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012701:Serotonin / Q000737:chemistry* / Q000378:metabolism*
D012333:RNA, Messenger; D012701:Serotonin; D000217:Acyltransferases
Arylalkylamine N-acetyltransferase; Arylalkylamine N-acyltransferase; Drosophila melanogaster; N-acyldopamine; N-acylserotonin; Steady-state kinetics; Thorax-abdomen