Selective DNA purine base photooxidation by bis-terdentate iridium(III) polypyridyl and cyclometalated complexes.
Two bis-terdentate iridium(III) complexes with polypyridyl and cyclometalated ligands have been prepared and characterized. Their spectroscopic and electrochemical properties have been studied, and a photophysical scheme addressing their properties is proposed. Different types of excited states have been considered to account for the deactivation processes in each complex. Interestingly, in the presence of mono- or polynucleotides, a photoinduced electron-transfer process from a DNA purine base (i.e., guanine or adenine) to the excited complex is shown through luminescence quenching experiments. For the first time, this work reports evidence for selective DNA purine bases oxidation by excited iridium(III) bis-terdentate complexes.
Institut de la Matière Condensée et des Nanosciences, Université Catholique de Louvain , Place Louis Pasteur 2, Box L4.01.02, B-1348 Louvain-la-Neuve, Belgium.
Alexandre
A
Jacques
Andrée
A
Kirsch-De Mesmaeker
Benjamin
B
Elias
D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D004247:DNA / Q000737:chemistry*; D007495:Iridium / Q000737:chemistry* / Q000494:pharmacology; D049449:Luminescence; D010083:Oxidants, Photochemical / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D011687:Purines / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology
D056831:Coordination Complexes; D010083:Oxidants, Photochemical; D011687:Purines; D011725:Pyridines; D007495:Iridium; D004247:DNA; C030985:purine