Epstein-Barr virus-associated T/natural killer-cell lymphomas in the elderly: the first consensus meeting in Kofu 2013.
From a clinicopathological conference on nine elderly patients with Epstein-Barr virus (EBV)-associated T/natural killer (NK)-cell lymphoma, we have addressed the patients' backgrounds, clinical manifestations, histopathological findings, cytogenesis, complications and prognoses. Among these elderly patients (>65 years old), seven patients had extranodal NK/T-cell lymphoma, nasal type (ENKL) with an NK-cell phenotype, and two patients had EBV(+) T-cell lymphomas or lymphoproliferative disorders (LPD) with cutaneous lesions mimicking pityriasis lichenoides et varioliformis acuta (PLEVA) or hydroa vacciniforme (HV). No patients had a previous episode of EBV-related symptoms such as infectious mononucleosis, chronic active EBV infection, HV or hypersensitivity to mosquito bites. Elderly patients with ENKL may show the centroblastoid variant. EBV(+) CD8(+) CD56(+/-) lymphocytes may be responsible for the development of PLEVA or HV-like cutaneous lesions in the elderly.
Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Toshihisa
T
Hamada
Shigeo
S
Nakamura
Young-Hyeh
YH
Ko
Tadashi
T
Yoshino
Koichi
K
Ohshima
Takamitsu
T
Matsuzawa
Keiko
K
Miura
Toshifumi
T
Takahashi
Hisashi
H
Nomura
Tomomi
T
Hoshino
Daisuke
D
Suzuki
Shinji
S
Shimada
Keiji
K
Iwatsuki
D000368:Aged; D000369:Aged, 80 and over; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000473:pathology; D006801:Humans; D008223:Lymphoma / Q000473:pathology / Q000821:virology*; D012867:Skin / Q000473:pathology
Epstein-Barr virus; T/natural killer-cell lymphoma; centroblastoid; hydroa vacciniforme; nasal type