Management of latent tuberculosis infection in child contacts of multidrug-resistant tuberculosis.
After exposure to a teacher with multidrug-resistant pulmonary tuberculosis, 31 children developed latent infection. Twenty-six were treated with levofloxacin and pyrazinamide. Twelve required a change in therapy secondary to adverse effects. The most common adverse effects included abdominal pain, arthralgias/myalgias and elevated transaminases. All children reported at least 1 adverse effect. Fifteen children completed treatment. All adverse effects were transient.
From the *Infectious Diseases, Children's Hospital Orange County, Orange; and † County of Orange Health Care Agency, Santa Ana, CA.
Felice C
FC
Adler-Shohet
Julie
J
Low
Michael
M
Carson
Haimanot
H
Girma
Jasjit
J
Singh
D000293:Adolescent; D019072:Antibiotic Prophylaxis / Q000009:adverse effects / Q000379:methods*; D000995:Antitubercular Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D016358:Contact Tracing; D006801:Humans; D055985:Latent Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D064704:Levofloxacin / Q000009:adverse effects / Q000627:therapeutic use; D011718:Pyrazinamide / Q000009:adverse effects / Q000627:therapeutic use; D012189:Retrospective Studies; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology
D000995:Antitubercular Agents; D011718:Pyrazinamide; D064704:Levofloxacin