[Morbidity and mortality cardiovascular risk in dependence of type 2 diabetes duration].
BACKGROUND
This study was aimed to assess the prognostic importance of diabetes duration to predict cardiovascular risk in type 2 diabetic patients.


METHODS
Prospective cohort study with inclusion of type 2 diabetic patients. Follow-up lasted until the appearance of a cardiovascular event, until death or until 2012. Patients were classified into 5 groups in accordance to diabetes duration and baseline cardiovascular disease (CVD): group 1: ≤ 5 years without CVD; group 2: 6-10 years without CVD; group 3: 11-15 years without CVD; group 4: >15 years without CVD; group 5: baseline CVD independently of diabetes duration. CVD rates were expressed per 1000 patients-year and compared by Kaplan-Meier analysis and Log Rank Test. The predictive power of diabetes duration was evaluated by Cox regression.


RESULTS
457 patients, aged 64.9 (DE 9.3) years (38.9% males), were included. Diabetes duration was 10.5 (DE 7.6) years. 125 cardiovascular events occurred during 12.3 years follow-up. Cardiovascular event rates were progressively increased from groups 1 to 5 (group 1: 14.1; group 2: 18.3; group 3: 19.6; group 4: 32.9; group 5: 53.5; p<0.0001, linear tendency). Diabetes duration superior to 15 years significantly increased cardiovascular risk of the patients (HR=1.97; 95%CI: 1.23-3.15; P=.004).


CONCLUSIONS
It could be useful to consider diabetes duration in order to stratify cardiovascular risk of type 2 diabetic patients.
Servicio Endocrinología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. Electronic address: jagimeno@salud.aragon.es.
José Antonio
JA
Gimeno Orna
Servicio Endocrinología, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España.
Yolanda
Y
Blasco Lamarca
Servicio Medicina Interna, Hospital Comarcal de Alcañiz, Alcañiz, Teruel, España.
Belén
B
Campos Gutierrez
Servicio Medicina Interna, Hospital Comarcal de Alcañiz, Alcañiz, Teruel, España.
Edmundo
E
Molinero Herguedas
Servicio Nefrología, Hospital Universitario Miguel Servet, Zaragoza, España.
Luis Miguel
LM
Lou Arnal
D000368:Aged; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors
Cardiovascular disease; Diabetes tipo2; Enfermedad cardiovascular; Evolución; Evolution; Type2 diabetes