Pleural epithelioid hemangioendothelioma harboring CAMTA1 rearrangement.
Pleural epithelioid hemangioendothelioma (EHE) is a very rare disease with adverse clinical outcomes. Recently, CAMTA1 rearrangement has been introduced as a consistent genetic abnormality in EHEs of different anatomical locations. We report a 71-year-old man with pleural EHE harboring CAMTA1 rearrangement confirmed by fluorescence in situ hybridization on paraffin embedded tissue.
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea.
Sang Yun
SY
Ha
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea.
In Ho
IH
Choi
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea. Electronic address: hanjho@skku.edu.
Joungho
J
Han
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea.
Yoon-la
YL
Choi
Department of Thoracic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea.
Jong Ho
JH
Cho
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea.
Kyung-Jong
KJ
Lee
Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Republic of Korea.
Jong-Mu
JM
Sun
D000368:Aged; D002135:Calcium-Binding Proteins / Q000235:genetics*; D015321:Gene Rearrangement / Q000235:genetics; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D015534:Trans-Activators / Q000235:genetics*
C487554:CAMTA1 protein, human; D002135:Calcium-Binding Proteins; D015534:Trans-Activators
CAMTA1; EHE; Epithelioid hemangioendothelioma; FISH; Lung; Pleura