Applications of surface-enhanced Raman scattering in advanced bio-medical technologies and diagnostics.
In this review of the literature on surface-enhanced Raman scattering (SERS), we describe recent developments of this technique in the medical field. SERS has developed rapidly in the last few years as a result of the fascinating advancements in instrumentation and the ability to interpret complex Raman data using high-processional, computer-aided programs. This technique, has many advantages over ordinary spectroscopic analytical techniques - such as extremely high sensitivity, molecular selectivity, intense signal and great precision - that can be leveraged to address complex medical diagnostics problems. This review focuses on the SERS-active substrate, as well as major advances in cancer and bacteria detection and imaging. Finally, we present a perspective on anticipated future advancements in SERS techniques to address some of the most critical challenges in the areas of diagnostics, detection, and sensing.
Center for Integrative Nanotechnology Sciences, University of Arkansas at Little Rock , Little Rock, AR , USA .
Zeid A
ZA
Nima
Abhijit
A
Biswas
Ilker S
IS
Bayer
Franklin D
FD
Hardcastle
Donald
D
Perry
Anindya
A
Ghosh
Enkeleda
E
Dervishi
Alexandru S
AS
Biris
D020811:Biomedical Technology / Q000295:instrumentation / Q000379:methods / Q000639:trends; D003936:Diagnosis, Computer-Assisted; D019719:Diagnostic Equipment; D004867:Equipment Design; D006801:Humans; D008962:Models, Theoretical; D025202:Molecular Diagnostic Techniques; D053758:Nanoparticles; D009369:Neoplasms / Q000175:diagnosis; D013059:Spectrum Analysis, Raman; D020349:Surface Plasmon Resonance