Synthesis and antinociception activity of new substituted phenothiazines and ethylenediamines as antihistaminic drugs.
Antihistamines play an important role in medicine when it comes to relieving seasonal or non-seasonal rhinitis, the common cold, and itching. They have also shown many various combinations of pharmacological properties such as anti-inflammatory and analgesic activities. Phenothiazines and ethylenediamines are 2 important classes of antihistamines with analgesic activities in addition to other pharmacological effects. In this study, some new derivatives of these compounds (V-IX) were synthesized and their antinociceptive behaviors were examined by pharmacological tests. The results indicated that new analogue with methyl groups produced a better analgesic activity than chlorine atoms but less than III (without any substitutions) in ethylenediamine class. Also in phenothiazine class, adding pyrimidine and pyridine substituted showed the better analgesic activity compared to other groups. Moreover, the analgesic activities proved that dimethylamine is the best group in amino alkyl side chain of these molecules relative to the substituted piperazines in new analogues.
Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran.
A
A
Ahmadi
School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
N
N
Naderi
Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran.
M
M
Souri
Department of Chemistry, Faculty of Science, Islamic Azad University, Shahre Ray Branch, Tehran, Iran.
F
F
Shirkavand
Department of Chemistry, Faculty of Science, Karaj Branch, Islamic Azad University, Karaj, Iran.
B
B
Nahri-Niknafs
D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000494:pharmacology; D006633:Histamine Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D000700:Analgesics; D005029:Ethylenediamines; D006633:Histamine Antagonists; D010640:Phenothiazines