Penicillipyrones A and B, meroterpenoids from a marine-derived Penicillium sp. fungus.
Penicillipyrones A (1) and B (2), two novel meroterpenoids, were isolated from the marine-derived fungus Penicillium sp. On the basis of the results of combined spectroscopic analyses, these compounds were structurally elucidated to be sesquiterpene γ-pyrones from a new skeletal class derived from a unique linkage pattern between the drimane sesquiterpene and pyrone moieties. Compound 2 elicited significant induction of quinone reductase.
Natural Products Research Institute, College of Pharmacy, Seoul National University , San 56-1, Sillim, Gwanak, Seoul 151-742, Korea.
Lijuan
L
Liao
Jung-Ho
JH
Lee
Minjung
M
You
Tae Joon
TJ
Choi
Wanki
W
Park
Sang Kook
SK
Lee
Dong-Chan
DC
Oh
Ki-Bong
KB
Oh
Jongheon
J
Shin
D000818:Animals; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011808:Quinone Reductases / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D011753:Pyrones; D012717:Sesquiterpenes; C000590073:penicillipyrone A; C000590074:penicillipyrone B; D011808:Quinone Reductases