Y-box binding protein 1--a prognostic marker and target in tumour therapy.
Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular processes including both transcriptional and translational regulation of target gene expression. Significantly increased YB-1 levels have been reported in a number of human malignancies and shown to be associated with poor prognosis and disease recurrence. Indeed, YB-1 can act as a versatile oncoprotein playing an important role in tumour cell proliferation and progression. Consequently, YB-1 not only proves to be a good prognostic tumour marker, but also may be a promising emerging molecular target for the development of new therapeutical strategies. In this review, we discuss both the role of YB-1 in cancer and specifically in malignant melanoma as well as possible translations into the clinics derived thereof.
Department of Dermatology, Division of Dermatooncology, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.
Corinna
C
Kosnopfel
Department of Dermatology, Division of Dermatooncology, Eberhard-Karls-Universität Tübingen, Tübingen, Germany.
Tobias
T
Sinnberg
Department of Dermatology, Division of Dermatooncology, Eberhard-Karls-Universität Tübingen, Tübingen, Germany. Electronic address: birgit.schittek@med.uni-tuebingen.de.
Birgit
B
Schittek
D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D051840:Y-Box-Binding Protein 1 / Q000235:genetics / Q000378:metabolism*
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D051840:Y-Box-Binding Protein 1
Angiogenesis; Chemoresistance; DNA repair; Genomic instability; Migration/invasion; Oncogene; Proliferation; Survival; Transcription factor; Translational regulation