GPR109a: the missing link between microbiome and good health?
A complex partnership between the host and the vast intestinal microbial ecosystem serves numerous biological activities including nutrition, immunity, and barrier function. In this issue of Immunity, Singh et al. (2014) demonstrate that microbial-derived butyrate mediated its protective activity against inflammation and colorectal cancer through GPR109a signaling.
Department of Medicine, Department of Infectious Diseases & Pathology, University of Florida, Gainesville, FL 32611, USA. Electronic address: christian.jobin@medicine.ufl.edu.
Christian
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D000818:Animals; D063646:Carcinogenesis / Q000276:immunology*; D003092:Colitis / Q000276:immunology*; D003106:Colon / Q000276:immunology*; D003110:Colonic Neoplasms / Q000517:prevention & control*; D004847:Epithelial Cells / Q000276:immunology*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism*
C473652:Hcar2 protein, mouse; D043562:Receptors, G-Protein-Coupled; D011978:Receptors, Nicotinic