Ratiometric MRI sensors based on core-shell nanoparticles for quantitative pH imaging.
Ratiometric MRI sensors consist of paramagnetic cores and pH-sensitive polymer shells. The core-shell nanostructure enables the coexistence of two incompatible NMR relaxation properties in one particle. The sensors show pH sensitivity in transverse relaxivity (r2 ), but not in longitudinal relaxivity (r1 ). Quantitative pH imaging is achieved by measuring the r2 /r1 value with a clinical 3 T MRI scanner.
Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Satoshi
S
Okada
Shin
S
Mizukami
Takao
T
Sakata
Yutaka
Y
Matsumura
Yoshichika
Y
Yoshioka
Kazuya
K
Kikuchi
D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry
D003287:Contrast Media; D056831:Coordination Complexes; D011108:Polymers; D005682:Gadolinium
contrast agents; core-shell nanoparticles; magnetic resonance imaging; pH-responsive polymers; ratiometric sensors