The potential role of angiogenic factors in rheumatoid arthritis.
Angiogenesis is an important phenomenon in the pathogenesis of some diseases, such as numerous types of tumors and autoimmunity, and also a number of soluble and cell-bound factors may stimulate neovascularization in inflammatory reaction processes. Here, by highlighting the significance of angiogenesis reaction in rheumatoid arthritis (RA), we will mainly focus on the role of various growth factors, cytokines, enzymes, cells, hypoxic conditions and transcription factors in the angiogenic process and we will then explain some therapeutic strategies based on blockage of angiogenesis and modification of the vascular pathology in RA.
Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.
Gholamreza
G
Azizi
Roobina
R
Boghozian
Abbas
A
Mirshafiey
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D042501:Angiogenic Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy; D009389:Neovascularization, Pathologic; D015398:Signal Transduction
D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins; D018501:Antirheumatic Agents; D016207:Cytokines
RA; VEGF; angiogenesis; cytokines; hypoxia