Lab-on-a-Chip Sensor with Evaporated Bismuth Film Electrode for Anodic Stripping Voltammetry of Zinc.
In this work, we report on the development of a lab-on-a-chip electrochemical sensor that uses an evaporated bismuth electrode to detect zinc using square wave anodic stripping voltammetry. The microscale electrochemical cell consists of a bismuth working electrode, an integrated silver/silver chloride reference electrode, and a gold auxiliary electrode. The sensor demonstrated linear response in 0.1 M acetate buffer at pH 6 with zinc concentrations ranging from 1 μM to 30 μM and a calculated detection limit of 60 nM. The sensor was also able to successfully detect zinc in a bovine serum extract and the results were verified with independent AAS measurements. These results demonstrate the advantageous qualities of this lab-on-a-chip electrochemical sensor for clinical applications, which include a small sample volume (μL scale), reduced cost, short response time and high accuracy at low concentrations of analyte.
BioMicroSystems Lab, Department of Electrical Engineering and Computing Systems, University Of Cincinnati, Cincinnati, OH, 45221 tel.: (513) 556-2347; fax: (513) 556-7326.
Wenjing
W
Kang
BioMicroSystems Lab, Department of Electrical Engineering and Computing Systems, University Of Cincinnati, Cincinnati, OH, 45221 tel.: (513) 556-2347; fax: (513) 556-7326.
Xing
X
Pei
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221.
Wei
W
Yue
Department of Chemistry, Xavier University, Cincinnati, OH, Cincinnati, OH 45221.
Adam
A
Bange
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221.
William R
WR
Heineman
BioMicroSystems Lab, Department of Electrical Engineering and Computing Systems, University Of Cincinnati, Cincinnati, OH, 45221 tel.: (513) 556-2347; fax: (513) 556-7326.
Ian
I
Papautsky