Enantioselective construction of vicinal all-carbon quaternary centers via catalytic double asymmetric decarboxylative allylation.
We report a catalytic stereoconvergent construction of vicinal all-carbon quaternary centers via double stereoablative enantioselective alkylation of a mixture having racemic and meso diastereomers of esters to afford exceptional levels of diastereo- (up to 17 : 1) and enantioselectivity (up to >99% ee). The strategy offers an efficient and general approach to dimeric cyclotryptamine alkaloids sharing a labile C(3a)-C(3a') σ-bond in the hexahydropyrroloindoline core.
Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhauri, Indore By-Pass Road, Bhopal, MP-462066, India. alakesh@iiserb.ac.in.
Santanu
S
Ghosh
Subhajit
S
Bhunia
Badrinath N
BN
Kakde
Subhadip
S
De
Alakesh
A
Bisai