Molecular tools for the construction of peptide-based materials.
Proteins and peptides are fundamental components of living systems where they play crucial roles at both functional and structural level. The versatile biological properties of these molecules make them interesting building blocks for the construction of bio-active and biocompatible materials. A variety of molecular tools can be used to fashion the peptides necessary for the assembly of these materials. In this tutorial review we shall describe five of the main techniques, namely solid phase peptide synthesis, native chemical ligation, Staudinger ligation, NCA polymerisation, and genetic engineering, that have been used to great effect for the construction of a host of peptide-based materials.
Radboud University Nijmegen, Institute for Molecules and Materials, Bio-Organic Chemistry, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands. d.lowik@science.ru.nl.
B E I
BE
Ramakers
J C M
JC
van Hest
D W P M
DW
Löwik
D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D005818:Genetic Engineering; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*
D001672:Biocompatible Materials; D004337:Drug Carriers; D053769:Nanocapsules; D010455:Peptides; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate