Lower serum uric acid levels in cerebral amyloid angiopathy: a pilot study.
Cerebral amyloid angiopathy (CAA) is a common degenerative disease presenting intracerebral hemorrhage (ICH) in older people. Uric acid (UA) is a natural antioxidant, and may have a beneficial role in neurodegenerative diseases. Nevertheless, the role of UA in CAA remains unknown. In the present study, we compared serum UA levels in CAA-associated ICH patients (n = 82) and age/sex-matched controls (n = 82). Serum UA levels in possible CAA were significantly decreased when compared with healthy controls (232.68 ± 77.70 vs. 309.42 ± 59.83 μmol/L; p < 0.001). Furthermore, UA levels in patients clinically diagnosed as probable CAA were significantly lower than those in patients diagnosed as possible CAA (193.06 ± 56.98 vs. 232.68 ± 77.70 μmol/L; p = 0.014). These differences were still significant after adjusting for renal function and dyslipidemia (p < 0.001 and p = 0.002, respectively). However, there were no associations between serum UA levels and the distribution of hemorrhagic lesion, as well as neurological impairment. Our observations indicate that serum UA levels were decreased in CAA patients. UA might play a neuroprotective role in CAA and serve as a potential biomarker for reflecting the severity of Aβ deposition.
Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Qi
Q
Hu
Anding
A
Liu
Mengyang
M
Huang
Luo
L
Cheng
Huicong
H
Kang
Feng
F
Xu
Xiaoyan
X
Liu
Lifei
L
Lian
Qiming
Q
Liang
Hong
H
Jiang
Cuntai
C
Zhang
Suiqiang
S
Zhu
D000368:Aged; D001794:Blood Pressure; D016657:Cerebral Amyloid Angiopathy / Q000097:blood*; D003401:Creatine / Q000097:blood; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D003401:Creatine