Manganese-mediated C3-selective direct alkylation and arylation of 2-pyridones with diethyl malonates and arylboronic acids.
A manganese-mediated dehydrogenative direct alkylation of 2-pyridones with diethyl malonates has been developed. A similar reaction system is applicable to the direct arylation with arylboronic acids. These manganese-based reactions occur regioselectively at the C3 position of the 2-pyridones. The observed high C3 regioselectivity can complement precedented C-H functionalization protocols of the 2-pyridones in view of the site selectivity.
Department of Applied Chemistry, Faculty of Engineering, Osaka University , Suita, Osaka 565-0871, Japan.
Akihiro
A
Nakatani
Koji
K
Hirano
Tetsuya
T
Satoh
Masahiro
M
Miura
D000478:Alkylation; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D008314:Malonates / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D015394:Molecular Structure; D011728:Pyridones / Q000737:chemistry*
D001897:Boronic Acids; D008314:Malonates; D011728:Pyridones; D008345:Manganese; C498810:diethyl malonate