Comparison between the effects of quercetin on seizure threshold in acute and chronic seizure models.
Flavonoids are important constituents of food and beverages, and several studies have shown that they have neuroactive properties. Many of these compounds are ligands for γ-aminobutyric acid type A receptors in the central nervous system. This study aimed to investigate the anticonvulsant effects of quercetin (3,3',4',5,7-pentahydroxyflavone), which is a flavonoid found in plants, in rats treated with pentylenetetrazole in acute and chronic seizure models. Single intraperitoneal administration of quercetin did not show anticonvulsive effects against acute seizure. Similarly, multiple oral pretreatment with quercetin did not have protective effects against acute seizure. However, multiple intraperitoneal administration of quercetin (25 and 50 mg/kg) significantly increased time to death compared with the control (p < 0.001). However, quercetin pretreatment had no significant effects on the pattern of convulsion development during all periods of kindling. But on the test day, quercetin (100 mg/kg) could significantly increase generalized tonic-clonic seizure onset (GTCS) and decrease GTCS duration compared with the control (p < 0.01, p < 0.05). We conclude that quercetin has a narrow therapeutic dose range for anticonvulsant activities in vivo, and it has different effects on the seizure threshold. The different effects of quercetin on seizure threshold may occur through several mechanisms.
Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran Department of Pharmacology, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran mnassiriasl@qums.ac.ir.
Marjan
M
Nassiri-Asl
School of Medicine, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.
Farid
F
Hajiali
School of Medicine, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.
Mina
M
Taghiloo
Department of Pharmacology, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.
Esmail
E
Abbasi
School of Medicine, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.
Fatemeh
F
Mohseni
School of Medicine, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.
Farbod
F
Yousefi
D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002908:Chronic Disease; D003292:Convulsants / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D010433:Pentylenetetrazole / Q000633:toxicity; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000145:classification / Q000188:drug therapy*
D000927:Anticonvulsants; D003292:Convulsants; D011794:Quercetin; D010433:Pentylenetetrazole
Flavonoids; acute seizure model; kindling; pentylenetetrazole; quercetin