Functional DNA nanomaterials for sensing and imaging in living cells.
Recent developments in integrating high selectivity of functional DNA, such as DNAzymes and aptamers, with efficient DNA delivery into cells by gold nanoparticles or superior near-infrared optical properties of upconversion nanoparticles are reviewed. Their applications in sensing and imaging small organic metabolites, toxins, metal ions, pH, DNA, RNA, proteins, and pathogens are summarized. The advantages and future directions of these functional DNA materials are discussed.
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States.
Seyed-Fakhreddin
SF
Torabi
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States. Electronic address: yi-lu@illinois.edu.
Yi
Y
Lu
D052157:Aptamers, Nucleotide / Q000737:chemistry; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D021881:DNA, Catalytic / Q000737:chemistry / Q000378:metabolism; D006046:Gold / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000737:chemistry; D018613:Microscopy, Confocal; D049329:Nanostructures / Q000737:chemistry*; D009369:Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D011859:Radiography
D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D006046:Gold; D004247:DNA