The validity of anthropometric leg muscle volume estimation across a wide spectrum: from able-bodied adults to individuals with a spinal cord injury.
The assessment of muscle volume, and changes over time, have significant clinical and research-related implications. Methods to assess muscle volume vary from simple and inexpensive to complex and expensive. Therefore this study sought to examine the validity of muscle volume estimated simply by anthropometry compared with the more complex proton magnetic resonance imaging ((1)H-MRI) across a wide spectrum of individuals including those with a spinal cord injury (SCI), a group recognized to exhibit significant muscle atrophy. Accordingly, muscle volume of the thigh and lower leg of eight subjects with a SCI and eight able-bodied subjects (controls) was determined by anthropometry and (1)H-MRI. With either method, muscle volumes were significantly lower in the SCI compared with the controls (P < 0.05) and, using pooled data from both groups, anthropometric measurements of muscle volume were strongly correlated to the values assessed by (1)H-MRI in both the thigh (r(2) = 0.89; P < 0.05) and lower leg (r(2) = 0.98; P < 0.05). However, the anthropometric approach systematically overestimated muscle volume compared with (1)H-MRI in both the thigh (mean bias = 2407cm(3)) and the lower (mean bias = 170 cm(3)) leg. Thus with an appropriate correction for this systemic overestimation, muscle volume estimated from anthropometric measurements is a valid approach and provides acceptable accuracy across a spectrum of adults with normal muscle mass to a SCI and severe muscle atrophy. In practical terms this study provides the formulas that add validity to the already simple and inexpensive anthropometric approach to assess muscle volume in clinical and research settings.
Department of Medicine, Division of Geriatrics, University of Utah, Salt Lake City, Utah;
Gwenael
G
Layec
Massimo
M
Venturelli
Eun-Kee
EK
Jeong
Russell S
RS
Richardson
D000328:Adult; D000886:Anthropometry / Q000379:methods; D005260:Female; D006801:Humans; D007866:Leg / Q000033:anatomy & histology* / Q000473:pathology / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000033:anatomy & histology* / Q000473:pathology / Q000502:physiology; D009133:Muscular Atrophy / Q000175:diagnosis* / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000175:diagnosis* / Q000503:physiopathology; D013848:Thigh / Q000033:anatomy & histology / Q000473:pathology / Q000502:physiology; D013904:Thoracic Vertebrae
atrophy; imaging; magnetic resonance; muscle mass; skeletal muscle