Serum uric acid: relationships with biomarkers in adolescents and changes over 1 year.
OBJECTIVE
To (1) elucidate the range of serum uric acid (UA) levels in adolescent sample; (2) examine the relationships of serum UA and 1-year change with gender, anthropometric and cardiometabolic factors.


METHODS
Measurements (anthropometrics, fasting venipuncture and blood pressure) were performed at the beginning of the seventh and eighth grades. Descriptive data, differences according to weight, correlations and changes over time were examined.


RESULTS
In 77 adolescents, BMI and serum UA had relationships with several cardiometabolic measures. Males had higher serum UA at follow-up compared to baseline; female change was minimal. Time-by-gender interaction was significant, as were the main effects of gender and BMI classification. Males had lower HDL-C at follow-up than at baseline; females had higher HDL-C at follow-up.


CONCLUSIONS
Serum UA has importance in cardiometabolic examination of youth risk factors. It should be examined in youth with elevated BMI and/or hypertension. Early adolescence is the period when gender-related metabolic changes occur.
Ruth C
RC
Bindler
Kenn B
KB
Daratha
Ross J
RJ
Bindler
Robert
R
Short
D000293:Adolescent; D000375:Aging / Q000378:metabolism*; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood*; D001835:Body Weight / Q000502:physiology; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000453:epidemiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009043:Motor Activity; D063766:Pediatric Obesity / Q000097:blood; D012307:Risk Factors; D012727:Sex Characteristics; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid