Investigating the clinical significance of mesh peritonization in abdominal vault suspension surgery using a comparative rabbit model.
OBJECTIVE
To investigate the clinical significance of mesh peritonization in an experimental rabbit model.


METHODS
Twenty rabbits were randomly assigned to two groups. A sacrouteropexy operation was performed in both groups using a polypropylene mesh. In the first group, the pelvic peritoneum was not closed over the mesh, and in the second group, the mesh was buried throughout the pelvic retroperitoneal tunnel. One month after mesh implantation, the abdomen was opened and the previous surgical site was explored. The primary outcome was intraabdominal adhesion formation; the secondary outcome was the histologic degree of tissue remodeling.


RESULTS
There were no statistically significant differences between the two groups in terms of adhesion scores and collagen organization (P=0.692, P=0.097, respectively). There was a greater degree of inflammation in the second group as identified by significantly higher scores for eosinophils-neutrophils, macrophages-foreign body giant cells and mononuclear cells (P=0.002, P=0.001 and P=0.002, respectively).


CONCLUSIONS
Similar adhesion and collagen organization patterns were found in both groups, but indicators of the inflammatory process were significantly higher in the second group.
Department of Obstetrics and Gynecology, Adana Numune Education and Research Hospital, Adana, Turkey. Electronic address: drhakannazik@gmail.com.
Hakan
H
Nazik
Department of Obstetrics and Gynecology, Adana Numune Education and Research Hospital, Adana, Turkey.
Mehmet Ali
MA
Narin
Department of Obstetrics and Gynecology, Adana Numune Education and Research Hospital, Adana, Turkey.
Raziye
R
Narin
Çukurova University, Faculty of Veterinary, Department of Veterinary, Adana, Turkey.
Kenan
K
Dağlıoğlu
Çukurova University, Department of Histology and Embryology, Faculty of Medicine, Adana, Turkey.
Ïrem
Ï
Ünal
Çukurova University, Department of Histology and Embryology, Faculty of Medicine, Adana, Turkey.
Ozgül
O
Tap
Department of Obstetrics and Gynecology, Mersin University Medical School, Mersin, Turkey.
Hakan
H
Aytan
D000818:Animals; D005260:Female; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D010537:Peritoneum / Q000473:pathology / Q000601:surgery*; D011817:Rabbits; D011897:Random Allocation; D013526:Surgical Mesh / Q000009:adverse effects*
Mesh; Peritonization; Rabbit model; Sacrohysteropexy; Uterine prolapse