Positive nuclear expression of KLF8 might be correlated with shorter survival in gastric adenocarcinoma.
Krűppel-like factor 8 (KLF8) is important in cell proliferation, epithelial-to-mesenchymal transition, cell migration, and invasion. Gastric adenocarcinoma is among the leading causes of cancer-related death in the world. In this study, the clinicopathologic correlation of KLF8 expression with gastric adenocarcinoma in Taiwan was investigated. The nuclear localization of KLF8 was correlated with advanced stage (P = .008) and 3-year survival rate (P = .043). The nuclear expression of KLF8 was significantly higher in the diffused type of gastric adenocarcinoma compared with the intestinal type (P = .036). Kaplan-Meier analysis results showed that patients with positive nuclear KLF8 had significantly lower overall survival rate compared with those with negative nuclear KLF8 (P = .011). Univariate analysis results indicated that positive nuclear KLF8 expression, advanced stage, and lymph node metastasis are correlated with lower overall survival. Positive nuclear KLF8 might be correlated with lower survival in gastric adenocarcinoma patients and might be an oncogene property in gastric adenocarcinoma carcinogenesis.
Institute of Biochemistry and Biotechnology, Chung Shan Medical University, Taichung, Taiwan; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung, Taiwan.
Li-Sung
LS
Hsu
Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan.
Pei-Ru
PR
Wu
Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Ken-Tu
KT
Yeh
Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan.
Chung-Min
CM
Yeh
Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan.
Ko-Hung
KH
Shen
Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan; Department of Medical Technology, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, Taiwan. Electronic address: 132540@cch.org.tw.
Chih-Jun
CJ
Chen
Department of Gastroenterology, Changhua Christian Hospital, Changhua, Taiwan. Electronic address: 2531@cch.org.tw.
Maw-Soan
MS
Soon
D000230:Adenocarcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D049109:Cell Proliferation; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D051741:Kruppel-Like Transcription Factors; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012097:Repressor Proteins / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D013624:Taiwan / Q000453:epidemiology; D046888:Tissue Array Analysis
D014408:Biomarkers, Tumor; C507402:KLF8 protein, human; D051741:Kruppel-Like Transcription Factors; D012097:Repressor Proteins
Gastric adenocarcinoma; Krűppel-like factor 8; survival