Drug-Induced Acute Liver Injury Within 12 Hours After Fluvastatin Therapy.
Although statins are generally well-tolerated drugs, recent cases of drug-induced liver injury associated with their use have been reported. A 52-year-old Chinese man reported with liver damage, which appeared 12 hours after beginning treatment with fluvastatin. Patient presented with complaints of increasing nausea, anorexia, and upper abdominal pain. His laboratory values showed elevated creatine kinase and transaminases. Testing for autoantibodies was also negative. The liver biochemistries eventually normalized within 3 weeks of stopping the fluvastatin. Therefore, when prescribing statins, the possibility of hepatic damage should be taken into account.
Department of Cardiovascular Medicine, The Tangshan Affiliated Clinical Hospital of Hebei Medical University, Tangshan, Hebei, P.R. China.
Li
L
Li
Yi
Y
Ma
Xue-Bin
XB
Geng
Yu-Xin
YX
Song
Zheng
Z
Tan
Xiao-Ming
XM
Shang
Guo-Yu
GY
Zhao
Bi-Qiong
BQ
Zhao
Mei-Rong
MR
Tian
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005229:Fatty Acids, Monounsaturated / Q000009:adverse effects*; D000077340:Fluvastatin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D007211:Indoles / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D000077340:Fluvastatin