Phagocyte roulette in Salmonella killing.
Salmonella propagates in macrophages to cause life-threatening infections, but the role of neutrophils in combating Salmonella has been controversial. In this issue, Burton et al. (2014) use single cell analyses and modeling to explain the ability of Salmonella to survive in macrophages while being killed by neutrophils.
Department of Microbiology, University of Illinois, Urbana, IL 61801-3709, USA.
Luke A
LA
Fenlon
Department of Microbiology, University of Illinois, Urbana, IL 61801-3709, USA; College of Medicine, University of Illinois, Urbana, IL 61801-3709, USA. Electronic address: slauch@illinois.edu.
James M
JM
Slauch
D000818:Animals; D005260:Female; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D012480:Salmonella Infections / Q000276:immunology* / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000502:physiology*; D013154:Spleen / Q000276:immunology*