To be or not to be a piRNA: genomic origin and processing of piRNAs.
Piwi-interacting RNAs (piRNAs) originate from genomic regions dubbed piRNA clusters. How cluster transcripts are selected for processing into piRNAs is not understood. We discuss evidence for the involvement of chromatin structure and maternally inherited piRNAs in determining their fate.
Adrien
A
Le Thomas
Katalin Fejes
KF
Tóth
Alexei A
AA
Aravin
D000818:Animals; D002843:Chromatin / Q000737:chemistry / Q000235:genetics; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D056426:Genetic Loci; D023281:Genomics / Q000379:methods*; D051379:Mice; D005810:Multigene Family; D034741:RNA, Small Interfering / Q000235:genetics* / Q000378:metabolism
D002843:Chromatin; D029721:Drosophila Proteins; D034741:RNA, Small Interfering