MiR-26a promotes ovarian cancer proliferation and tumorigenesis.
MicroRNAs (miRNAs) important for posttranscriptional gene expression are involved in the initiation and progression of human cancer. In this study, we reported that miR-26a was over-expressed in human EOC specimens and the expression level of extracellular miR-26a in plasma can distinguish patients from healthy controls in EOC. Ectopic expression of miR-26a in ovarian cancer (OC) cells increased cell proliferation and clonal formation. This growth promoting effect of OC cell growth was mediated by miR-26a inhibition of the posttranscription of ER-α. Furthermore, inhibition of miR-26a suppressed the tumor formation generated by injecting OC cells in nude mice. Our results suggest that aberrantly expressed miR-26a may contribute to OC development.
Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Wenjing
W
Shen
Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Institute of Pathology and Pathophysiology, Shenyang, China.
Min
M
Song
Experimental Technology Center, China Medical University, Shenyang, China.
Jie
J
Liu
Department of Medical Genetics, China Medical University, Shenyang, China.
Guangrong
G
Qiu
Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Tianren
T
Li
Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yanjie
Y
Hu
Department of Health Statistics, School of Public Health, China Medical University, Shenyang, China.
Hongbo
H
Liu
D000818:Animals; D015153:Blotting, Western; D063646:Carcinogenesis / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D003001:Cloning, Molecular; D005260:Female; D006801:Humans; D008156:Luciferases; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000503:physiopathology*; D060888:Real-Time Polymerase Chain Reaction; D018709:Statistics, Nonparametric
D008156:Luciferases; D035683:MicroRNAs; C528163:MIRN26 microRNA, human