Magnetic resonance guided high-intensity focused ultrasound for image-guided temperature-induced drug delivery.
Magnetic resonance guided high-intensity focused ultrasound (MR-HIFU) is a versatile technology platform for noninvasive thermal therapies in oncology. Since MR-HIFU allows heating of deep-seated tissue to well-defined temperatures under MR image guidance, this novel technology has great potential for local heat-mediated drug delivery from temperature-sensitive liposomes (TSLs). In particular, MR provides the ability for image guidance of the drug delivery when an MRI contrast agent is co-encapsulated with the drug in the aqueous lumen of the liposomes. Monitoring of the tumor drug coverage offers possibilities for a personalized thermal treatment in oncology. This review focuses on MR-HIFU as a noninvasive technology platform, temperature-sensitive liposomal formulations for drug delivery and image-guided drug delivery, and the effect of HIFU-induced hyperthermia on the TSL and drug distribution. Finally, the opportunities and challenges of localized MR-HIFU-mediated drug delivery from temperature-sensitive liposomes in oncology are discussed.
Eindhoven University of Technology, Dept. of Biomedical NMR, Eindhoven, The Netherlands; Center for Imaging Research and Education (CIRE), Eindhoven, The Netherlands.
Nicole
N
Hijnen
Philips Research Eindhoven, Minimally Invasive Healthcare, Eindhoven, The Netherlands; Center for Imaging Research and Education (CIRE), Eindhoven, The Netherlands.
Sander
S
Langereis
Eindhoven University of Technology, Dept. of Biomedical NMR, Eindhoven, The Netherlands; Philips Research Eindhoven, Minimally Invasive Healthcare, Eindhoven, The Netherlands; Center for Imaging Research and Education (CIRE), Eindhoven, The Netherlands. Electronic address: h.gruell@tue.nl.
Holger
H
Grüll
D000818:Animals; D016503:Drug Delivery Systems; D057086:High-Intensity Focused Ultrasound Ablation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000628:therapy; D013696:Temperature
Doxorubicin; Drug delivery; MR image guidance; MR-HIFU; Temperature-sensitive liposomes; Ultrasound