Influence of radiolytic-produced hydrogen peroxide on the stability of commercial kit (99m) technetium-exametazime preparation.
99mTc-d,l-hexamethylpropylene amine oxime ((99m) Tc-d,l-HMPAO) is a widely used radiopharmaceutical that suffers from an inherent instability with a shelf life of 30 min that constrains its availability for clinical use. A protocol for improving the stability of the kit with minimal modification of manufacturer's instructions and no chemicals addition to the commercial formulation is proposed. The protocol is based on the displacement of the oxygen present in the preparation, preventing free radicals build up and free pertechnetate formation. Although the degradation of (99m) Tc-d,l-HMPAO cannot be explained solely by the radiolytic production of free radicals, it appears to be an important factor in the shelf stability of the complex.
Hospital General Universitario Santa Lucia, Unidad de Radiofarmacia, Cartagena, Murcia, Spain.
Teresa
T
Martinez
Elena
E
Miñana
Tomás Chivato
TC
Martín-Falquina
Teodomiro
T
Fuente
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006861:Hydrogen Peroxide / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry; D011854:Radiochemistry; D013670:Sodium Pertechnetate Tc 99m / Q000737:chemistry; D019690:Technetium Tc 99m Exametazime / Q000737:chemistry*; D013997:Time Factors
D019690:Technetium Tc 99m Exametazime; D013670:Sodium Pertechnetate Tc 99m; D006861:Hydrogen Peroxide; D010100:Oxygen
99mTc; 99mTc-d,l-hexamethylpropylene amine oxime; hydrogen peroxide; radiochemical purity; radiolysis; radiopharmaceutical; stability