The effect of trapidil and bevacizumab on tracheal anastomotic wound healing.
BACKGROUND
Although bevacizumab has deleterious effects on the healing of colonic anastomoses, trapidil improves wound healing of colonic and tracheal anastomoses.


OBJECTIVE
We aimed to assess the effects of bevacizumab and trapidil on wound healing after tracheal transection.


METHODS
We evaluated 35 rats divided in 5 groups: bevacizumab (Group I, n = 7), trapidil (Group II, n = 7), trapidil + bevacizumab (Group III, n = 7), controls (Group IV, n = 7), and sham (Group V, n = 7). Anastomotic healing was assessed by measurement of bursting pressure and inflammation score at the anastomotic region on the seventh day.


RESULTS
The bursting pressures of Group II, Group III, and Group V were significantly higher than controls (P = 0.001, P = 0.033, and P = 0.035, respectively). Fibrosis was significantly high in the sham group when compared with the other four groups (P = 0.047).


CONCLUSIONS
Although bevacizumab seems to impair anastomotic healing, trapidil can be suggested to improve tracheal anastomoses.
Yedikule Chest Disease Hospital, Istanbul, Turkey.
Esra
E
Ertan
Mersin University Faculty of Medicine, Mersin, Turkey.
Perihan
P
Göçer
Mersin University Faculty of Medicine, Pediatric Surgery, Mersin, Turkey.
Ali
A
Naycı
Mersin University Faculty of Medicine, Biophysic Department, Mersin, Turkey.
Ulkü
U
Cömelekoğlu
Mersin University Faculty of Medicine, Chest Disease Department, Mersin, Turkey.
Sibel
S
Atış
Mersin University Faculty of Medicine, Pathology Department, Mersin, Turkey.
Rabia
R
Bozdağan Arpacı
Mersin University Faculty of Medicine, Infectious Disease Department, Mersin, Turkey ; Mersin University Faculty of Medicine, Ear Nose Throat Department, Mersin, Turkey.
Gülden
G
Ersöz
Mersin University Faculty of Medicine, Ear Nose Throat Department, Mersin, Turkey.
Savaş
S
Körlü
Mersin University Faculty of Medicine, Ear Nose Throat Department, Mersin, Turkey.
Derya
D
Umit Talas
bevacizumab; tracheal transaction; trapidil; wound healing