Red ginseng (Panax ginseng) decreases isoproterenol-induced cardiac injury via antioxidant properties in porcine.
Red ginseng (RG, Panax ginseng) has been shown to possess various ginsenosides. These ginsenosides are widely used for treating cardiovascular diseases in Asian communities. The present study was designed to evaluate the cardioprotective potential of RG against isoproterenol (ISO)-induced myocardial infarction (MI), by assessing electrocardiographic, hemodynamic, and biochemical parameters. Male porcines were orally administered with RG (250 and 500 mg/kg) or with vehicle for 9 days, with concurrent intraperitoneal injections of ISO (20 mg/kg) on the 8th and 9th day. RG significantly attenuated ISO-induced cardiac dysfunctions as evidenced by improved ventricular hemodynamic functions and reduced ST segment and QRS complex intervals. Also, RG significantly ameliorated myocardial injury parameters such as antioxidants. Malonaldialdehyde formation was also inhibited by RG. Based on the results, it is concluded that RG possesses significant cardioprotective potential through the inhibition of oxidative stress and may serve as an adjunct in the treatment and prophylaxis of MI.
1 Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University , Jeonju City, Jeollabuk-Do, Korea.
Kyu Hee
KH
Lim
Jae Youl
JY
Cho
Bumseok
B
Kim
Bong-Seuk
BS
Bae
Jong-Hoon
JH
Kim
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D036145:Ginsenosides / Q000008:administration & dosage; D006801:Humans; D007545:Isoproterenol / Q000009:adverse effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009203:Myocardial Infarction / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000008:administration & dosage*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013552:Swine
D000975:Antioxidants; D036145:Ginsenosides; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D007545:Isoproterenol