A new approach to glycan targeting: enzyme inhibition by oligosaccharide metalloshielding.
Metalloglycomics - the effects of defined coordination compounds on oligosaccharides and their structure and function - opens new areas for bioinorganic chemistry and expands its systematic study to the third major class of biomolecules after DNA/RNA and proteins.
Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, USA. npfarrell@vcu.edu.
John B
JB
Mangrum
Brigitte J
BJ
Engelmann
Erica J
EJ
Peterson
John J
JJ
Ryan
Susan J
SJ
Berners-Price
Nicholas P
NP
Farrell
D056831:Coordination Complexes / Q000737:chemistry*; D000077425:Fondaparinux; D006493:Heparin / Q000031:analogs & derivatives* / Q000737:chemistry; D019763:Heparin Lyase / Q000037:antagonists & inhibitors / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry*; D011509:Proteoglycans / Q000737:chemistry*
D056831:Coordination Complexes; D011134:Polysaccharides; D011509:Proteoglycans; C036090:heparin proteoglycan; D010984:Platinum; D006493:Heparin; D019763:Heparin Lyase; D000077425:Fondaparinux