[Importance of diabetic nephropathy in childhood. Clinical findings and basic research in recent decades].
Over the past decades diabetes mellitus is becoming a global pandemic affecting more than 371 million people worldwide. Parallel with the increasing prevalence of type 1 diabetes, there is a growing number of type 2 diabetes cases among children and adolescents that poses new challenges to pediatricians. Diabetic nephropathy is one of the major causes of end stage renal disease, developing in approximately 30% of diabetic patients. However, overt nephropathy is rare in childhood; screening and ongoing assessment for the earliest manifestation of renal injury is extremely important in this young population, as well. Although in the past decades intensive research activity focused on understanding of the pathomechanism of diabetic nephropathy and invention of new therapeutic approaches, prevention and definitive care are still urgently needed. The clinical section of the article summarizes the present state of epidemiology, diagnosis and current therapies of childhood diabetic nephropathy. Then, the authors discuss the state of basic research and show a few promising targets for drug development.
Semmelweis Egyetem, Általános Orvostudományi Kar I. Gyermekgyógyászati Klinika, MTA-SE Lendület Diabétesz Kutatócsoport Budapest Bókay J. u. 53. 1083.
Andrea
A
Fekete
MTA-SE Gyermekgyógyászati és Nephrologiai Kutatócsoport Budapest.
Ádám
Á
Vannay
D000293:Adolescent; D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D035843:Biomedical Research / Q000639:trends; D002648:Child; D002675:Child, Preschool; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology / Q000628:therapy; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D058990:Molecular Targeted Therapy / Q000639:trends; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D016212:Transforming Growth Factor beta / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D004791:Enzyme Inhibitors; D016212:Transforming Growth Factor beta; D000449:Aldehyde Reductase; D011493:Protein Kinase C
animal study; diabetes; kidney; nephropathia; nephropathy; vese; állatkísérlet