The detrimental role of glial acidification during ischemia.
In this issue of Neuron, Beppu et al. (2014) demonstrate that glial acidification during ischemia contributes to neurotoxicity. Using a suite of in vivo optogenetic tools, the authors are able to exacerbate or attenuate neuronal damage during ischemia with glial acidification or alkalization, respectively.
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA. Electronic address: ssloan1@stanford.edu.
Steven A
SA
Sloan
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA.
Ben A
BA
Barres
D000138:Acidosis; D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism*; D020925:Hypoxia-Ischemia, Brain / Q000150:complications*; D009457:Neuroglia / Q000378:metabolism*; D062308:Optogenetics
D018698:Glutamic Acid