Metachronous multiple primary malignant neoplasms of the stomach and the breast: report of two cases with review of literature.
Multiple primary malignant neoplasm is the occurrence of a second primary malignancy in the same patient within 6 months of the detection of first primary (synchronous), or 6 months or more after primary detection (metachronous). Multiple primary malignant neoplasms are not very frequently encountered in clinical practice. The relative risk for a second primary malignancy increases by 1.111-fold every month from the detection of the first primary malignancy in any individual. We present 2 patients treated for carcinoma of the breast who developed a metachronous primary malignancy in the stomach to highlight the rare occurrence of multiple primary malignant neoplasms. These tumors were histologically dissimilar, with distinct immunohistochemical parameters. The importance lies in carefully identifying the second primary malignancies, not dismissing them as metastases, and treating them accordingly.
1 Department of Urology, 2Department of Surgery, 3Department of Surgical Gastroenterology, 4Department of Pathology, and 5Department of Medical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Vilvapathy Senguttuvan
VS
Karthikeyan
Sarath Chandra
SC
Sistla
Ramachandran
R
Srinivasan
Debdatta
D
Basu
Lakshmi C
LC
Panicker
Sheik Manwar
SM
Ali
Nagarajan
N
Rajkumar
D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000473:pathology*; D013274:Stomach Neoplasms / Q000473:pathology*