Introduction of Organic Anion Transporters (SLC22A) and a Regulatory Mechanism by Caveolins.
The kidney is an important organ for controlling the volume of body fluids, electrolytic balance and excretion/reabsorption of endogenous and exogenous compounds. Among these renal functions, excretion/reabsorption of endogenous and exogenous substance is very important for the maintenance of physiological homeostasis in the body. Recently discovered organic anion transporters (OAT or SLC22A) have important roles for renal functions. It is well known as drug transporter. Several isoforms belong to SLC22A family. They showed different transport substrate spectrums and different localizations within the kidney. Their gene expressions are changed by some stimulus. The functional transport properties are regulated by protein kinase C. In addition, the function of organic anion transporters are also regulated by protein-protein interaction, such as caveolin which is compositional protein of caveolae structure. In this review, we will give an introduction of organic anion transporters and its regulatory mechanisms.
Department of Laboratory Animal, Medical Research Center, College of Medicine, Yonsei University, Seoul, Korea.
Woon Kyu
WK
Lee
Department of Pharmacology and Toxicology, College of Medicine, Inha University, Inchon, Korea.
Sun-Mi
SM
Jung
Department of Pharmacology and Toxicology, College of Medicine, Inha University, Inchon, Korea.
Jin-Oh
JO
Kwak
Department of Pharmacology and Toxicology, College of Medicine, Inha University, Inchon, Korea.
Seok Ho
SH
Cha
Caveolin; Kidney; Multispecific organic anion transporter; Organic anion; Renal localization; Tubular secretion; Xenobiotics