Do YB2/0 cells produce alien sugars?
Olovnikova et al. ("Impact on N-glycosylation profile of monoclonal anti-D antibodies as a way to control their immunoregulatory and cytotoxic properties" (2012) Biochemistry (Moscow), 77, 925-933) mentioned the presence of "alien sugars" on monoclonal antibodies (mAbs) produced by YB2/0 cell line. We summarize in this paper our previous findings on the glycosylation profile of two anti-D mAbs produced in this cell line (LFB-R297 and LFB-R593, so-called Roledumab). Our results show the absence of any immunogenic glycotopes, and furthermore neither immunogenicity nor other serious adverse reactions were observed during clinical trials.
Development Program Department, LFB Biotechnologies, BP 50052, 91 942 Courtaboeuf Cedex, France. quagliaroli@lfb.fr.
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Quagliaroli
D000911:Antibodies, Monoclonal / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology*
D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents