Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population.
OBJECTIVE
Aldehyde dehydrogenase 2 (ALDH2) is a well-known gene involved in alcohol and aldehyde metabolism. Moreover, recent studies have reported associations between ALDH2 and age-related disorders. Benign prostate hyperplasia (BPH) is an age-related disorder and genetic factors may contribute to its onset. In this study, we investigated the association of a well-studied ALDH2 single nucleotide polymorphism (SNP), rs671, with the onset and clinical features of BPH.


METHODS
A total of 222 BPH patients and 214 control subjects were genotyped. The clinical features of the BPH patients (prostate volume, prostate-specific antigen level, and International Prostatic Symptom Score) were analyzed.


RESULTS
The results show that rs671 was only associated with the volume of BPH in genotype and allele frequencies (P<0.05).


CONCLUSIONS
We propose that rs671 is an Asian-specific SNP in ALDH2 that may affect the disease progression of BPH in the Korean population.
Department of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
Hosik
H
Seok
Department of Urology, Kyung Hee University School of Medicine, Seoul, Korea.
Koo Han
KH
Yoo
Development of Ginseng and Medical Plants Research Institute, Rural Administration, Eumseong, Korea.
Young Ock
YO
Kim
Department of Pharmacology and Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
Joo-Ho
JH
Chung
Aldehyde dehydrogenase 2; Prostatic hyperplasia; Single nucleotide polymorphism