Enlightened Mannhemia haemolytica lung inflammation in bovinized mice.
Polymorphonuclear cells diapedesis has an important contribution to the induced Mannhemia haemolytica (M. haemolytica) infection lung inflammation and IL-8 is the primary polymorphonuclear chemoattractant. Using a bovine IL-8/luciferase transiently transgenized mouse model, the orchestration among M. haemolytica, IL-8 promoter activation and neutrophilia was followed in real time by in vivo image analysis.
Fabio Franco
FF
Stellari
Sophia
S
Lavrentiadou
Francesca
F
Ruscitti
Sarah
S
Jacca
Valentina
V
Franceschi
Maurizio
M
Civelli
Chiara
C
Carnini
Gino
G
Villetti
Department of Medical Veterinary Science, University of Parma, via del Taglio 10, 43126 Parma, Italy. gaetano.donofrio@unipr.it.
Gaetano
G
Donofrio
D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D005260:Female; D016209:Interleukin-8 / Q000378:metabolism*; D008156:Luciferases / Q000378:metabolism; D049408:Luminescent Agents / Q000378:metabolism; D008168:Lung / Q000276:immunology / Q000382:microbiology; D016978:Mannheimia haemolytica / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D009504:Neutrophils / Q000276:immunology* / Q000382:microbiology; D010326:Pasteurella Infections / Q000276:immunology*; D018410:Pneumonia, Bacterial / Q000276:immunology*
D016209:Interleukin-8; D049408:Luminescent Agents; D008156:Luciferases