A novel scientific model for rare and often neglected neoplastic conditions.
Study Type Retrospective cohort. Introduction The treatment of rare neoplastic conditions is challenging, especially because studies providing high levels of evidence are often lacking. Such is the case with primary tumors of the spine (PTS), which have a low incidence, are pathologically heterogeneous, and have diverse treatment approaches.1 Despite these difficulties, appropriate evidence-based care of these complex patients is imperative. Failure to follow validated oncologic principles may lead to unnecessary mortality and profound morbidity. Objective With the aim of offering patients the most appropriate treatment based on the best available evidence, a novel scientific model was developed and employed. This article outlines this model, which has not only provided significant evidence guiding treatment of this rare condition, but we believe is readily transferrable to other similarly rare conditions. Methods A four-stage approach was employed. (1) Planning: Data from large volume centers were reviewed together with results from a feasibility questionnaire to provide insight into epidemiology, patient volumes, tumor pathology, treatment modalities, and outcomes. (2) Recruitment: Centers with sufficient volume and valid data were enrolled and provided with the necessary infrastructure. This included study coordinators and a secure, Web-based database (REDCap, Vanderbilt University, Nashville, Tennessee, United States) to capture international data from six modules comprising: demographic, clinical, diagnostic, therapeutic, local recurrence, perioperative morbidity fields, and a cross-sectional survey to update survival information. The AOSpine Knowledge Forum Tumor designed these modules and provided funding. Each center received institutional ethics approval. (3) Retrospective stage: Prospectively collected data from all recruited centers were reviewed and analyzed retrospectively. (4) Prospective stage: Following interim analysis, prospective data collection has been implemented. In addition, a PTS bio-bank network has been created to link clinical data with tumor pathology and molecular analysis. Results It took 18 months to implement stages 1 to 3 of this model and stage 4 is ongoing. A total of 1,495 tumor cases were captured and diagnosed as one of the 18 primary spine tumor subtypes listed (Fig. 1). The most prevalent diagnosis was chordoma (n = 344, 23%). There were 674 females and 821 males with a mean age of 43 ± 19 years at the time of surgery. Surgical treatment was performed between 1981 and 2012. The survival at 5 and 10 years postsurgery was 71.9 and 53.3%, respectively, with a median survival of 13 years postsurgery (Fig. 2). Conclusions To date, this is the largest international collection of PTS. This novel scientific model has not only aggregated a large amount of PTS data, but has also established an international collaborative network of spine oncology centers. The access to large volumes of clinical and bio-bank data will generate further research to guide and enhance the clinical management of PTS. This novel scientific model could be of similar tremendous value if applied to other rare neoplastic conditions.
Division of Spine, Department of Orthopaedics, University of British Columbia and Vancouver Coastal Health, Vancouver, British Columbia, Canada.
Charles G
CG
Fisher
Division of Spine, Department of Orthopaedics, University of British Columbia and Vancouver Coastal Health, Vancouver, British Columbia, Canada.
Tony
T
Goldschlager
Department of Degenerative and Oncological Spine Surgery, Rizzoli Institute, Bologna, Italy.
Stefano
S
Boriani
National Center for Spinal Disorders and Buda Health Center, Budapest, Hungary.
Peter Pal
PP
Varga
Division of Neurosurgery, Department of Surgery, University of Toronto and Toronto Western Hospital, Toronto, Ontario, Canada.
Michael G
MG
Fehlings
Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York, United States.
Mark H
MH
Bilsky
Orthopaedic Surgery, The CORE Institute, Sun City West, Arizona, United States.
Mark B
MB
Dekutoski
Oncologia Ortopedica e Ricostruttiva del Rachide, Istituto Ortopedico Galeazzi, Milano, Italy.
Alessandro
A
Luzzati
Department of Orthopaedics, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Richard P
RP
Williams
Department of Orthopaedic Surgery, University of California San Francisco, San Francisco, California, United States.
Sigurd
S
Berven
Department of Neurological Surgery, University of California San Francisco, San Francisco, California, United States.
Dean
D
Chou
Spinal Division, Oxford University Hospital NHS Trust, Oxford, United Kingdom.
Jeremy J
JJ
Reynolds
Queens Medical Centre, Nottingham University Hospital NHS Trust, Nottingham, United Kingdom.
Nasir A
NA
Quraishi
Department of Neurosurgery, MD Anderson Cancer Center, The University of Texas, Houston, Texas, United States.
Laurence D
LD
Rhines
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Chetan
C
Bettegowda
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Ziya L
ZL
Gokaslan
collection; primary tumor; rare disease; scientific model; spine