Benefits of the neutrophil-to-lymphocyte ratio for the prediction of gestational diabetes mellitus in pregnant women.
OBJECTIVE
There is growing consensus in the literature that inflammation plays a central role in the pathophysiology of obesity, Type 2 Diabetes Mellitus (T2DM), Gestational Diabetes Mellitus (GDM) and cardiovascular complications. Measuring the neutrophil-to-lymphocyte ratio (NLR) provides a simple inexpensive method for the assessment of inflammatory status. We investigated the predictive value of pre-procedural (before the oral glucose tolerance test (OGTT)) NLR on the development of GDM in pregnancy.


METHODS
42 women with GDM and 68 women without GDM were included in the study. Complete Blood Count and biochemical tests were followed by a diagnostic 4-point 100-g-OGTT within 2 weeks. GDM was diagnosed by the Carpenter and Coustan criteria. The NLR was calculated from the data.


RESULTS
The mean NLR level was significantly higher in GDM women (3.00±0.83 vs. 2.26±0.43 p<0.001, respectively). In ROC analysis, NLR>2.93 had 76.2% sensitivity and 94.1% specificity in predicting GDM. Logistic regression analysis showed that elevated NLR (OR: 5.512, 95% CI: 1.352-22.475, p=0.017) was an independent variable for predicting GDM in pregnancy.


CONCLUSIONS
An elevated NLR level is a powerful and independent predictor of GDM. The results of this study suggested that inflammation plays a central role in the pathogenesis of GDM.
Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
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H
Yilmaz
Turgut Ozal University, School of Medicine, Biochemistry, Ankara, Turkey.
H T
HT
Celik
Turgut Ozal University, School of Medicine, Biochemistry, Ankara, Turkey.
M
M
Namuslu
Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
O
O
Inan
Turgut Ozal University, School of Medicine, Obstetrics and Gynecology, Ankara, Turkey.
Y
Y
Onaran
Necmettin Erbakan University, School of Medicine Konya, Turkey.
F
F
Karakurt
Agn State Hospital, Biochemistry, Agn, Turkey.
A
A
Ayyildiz
Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
M A
MA
Bilgic
Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
N
N
Bavbek
Turgut Ozal University, School of Medicine, Internal Medicine, Ankara, Turkey.
A
A
Akcay
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D016640:Diabetes, Gestational / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000166:cytology*; D009504:Neutrophils / Q000166:cytology*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
D001786:Blood Glucose