Update on idiopathic hirsutism: diagnosis and treatment.
Idiopathic hirsutism (IH) is defined as hirsutism in conjunction with normal ovulatory function and normal serum androgen levels. The pathogenesis of IH is still not clear. Increased peripheral 5alpha-reductase enzyme activity and abnormalities of androgen receptor gene polymorphisms have been postulated to explain the pathogenesis of this disorder. It is diagnosed in women who have hirsutism, normal ovulatory function, and normal levels of serum total or free testosterone. Combination treatment of IH, including androgen suppression, peripheral androgen blockade and cosmetic methods is most effective.
Department of Internal Medicine, Division of Endocrinology and Metabolism, Karadeniz Technical University. cihangirerem@hotmail.com
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D000726:Androgen Antagonists / Q000627:therapeutic use*; D000736:Androstenes / Q000627:therapeutic use; D000813:Anilides / Q000627:therapeutic use; D003278:Contraceptives, Oral, Hormonal / Q000627:therapeutic use*; D017373:Cyproterone Acetate / Q000627:therapeutic use; D005260:Female; D018120:Finasteride / Q000627:therapeutic use; D005485:Flutamide / Q000627:therapeutic use; D006204:Hair Removal / Q000379:methods; D006628:Hirsutism / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use; D009570:Nitriles / Q000627:therapeutic use; D013148:Spironolactone / Q000627:therapeutic use; D014105:Tosyl Compounds / Q000627:therapeutic use
D000726:Androgen Antagonists; D000736:Androstenes; D000813:Anilides; D003278:Contraceptives, Oral, Hormonal; D009570:Nitriles; D014105:Tosyl Compounds; D013148:Spironolactone; D017373:Cyproterone Acetate; D018120:Finasteride; D005485:Flutamide; C053541:bicalutamide; D016729:Leuprolide; C035144:drospirenone