Blood group type antigens in pancreatic intraductal papillary mucinous neoplasms.
BACKGROUND
There are few data on blood group (BG) types and types of pancreatic cancers. The aims of this study were to study BG types and BG-antigens in pancreatic intraductal papillary mucinous neoplasms (IPMNs).


METHODS
BG type and tumor BG-antigen (glycoprotein) expression (studied by immunohistochemistry on tissue microarrays) were analyzed with regard to characteristics of 101 surgically resected pancreatic IPMNs.


RESULTS
Non-O BG type predicted invasive carcinoma independently from high serum CA19-9 and male gender. BG type A was observed more frequently in women than in men. Chronic pancreatitis was more frequently seen in patients with BG type B or AB. Aberrant tumor expression (with regard to BG type) of loss of A antigen expression type occurred in 15.0% of IPMNs and of loss of B antigen expression type in 62.5% of IPMNs. Intraneoplasm BG-antigen expression was not related to dysplasia grade or invasion.


CONCLUSIONS
The results of the study suggest that in pancreatic IPMN, non-O BG type predicted invasive carcinoma, whereas for intratumor BG-antigen expression no specific patterns were detected with regard to the progression of glandular epithelial dysplasia or invasion.
Departments of Pathology, Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA; and APHP Universite Paris Nord Sorbonne Cite-Sce Anatomie Pathologique, GHU Avicenne, 125 rue Stalingrad, Bobigny 93000, France. adriana.handra-luca@avc.aphp.fr.
Adriana
A
Handra-Luca
D002288:Adenocarcinoma, Mucinous / Q000276:immunology* / Q000401:mortality; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000941:Antigens / Q000378:metabolism*; D001789:Blood Group Antigens / Q000276:immunology*; D021441:Carcinoma, Pancreatic Ductal / Q000276:immunology* / Q000401:mortality; D002291:Carcinoma, Papillary / Q000276:immunology* / Q000401:mortality; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000276:immunology* / Q000401:mortality; D012189:Retrospective Studies; D012737:Sex Factors; D015996:Survival Rate; D046888:Tissue Array Analysis
D000941:Antigens; D001789:Blood Group Antigens