Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts.
Curcumin is a natural phenolic compound extracted from the plant Curcuma longa L. In previous studies, curcumin has been shown to have anticancer, antioxidant, and anti-inflammatory effects. In this study, the cytotoxicity of different concentrations (5, 10, 25, 50, 75, and 100 μM) of curcumin dissolved in dimethyl sulfoxide was compared between MG-63 osteosarcoma and healthy human osteoblast cells. Consequently, the viability of osteosarcoma cells was less than 50% at a concentration of 10 μM compared to the control sample without curcumin, but healthy osteoblast cells had at least 80% viability throughout all the concentrations tested. The results demonstrated that MG-63 osteosarcoma cells were much more sensitive in terms of cytotoxicity to curcumin, while the healthy human osteoblasts exhibited a higher healthy viability after 24 hours of curcumin treatment. Therefore, this study showed that at the right concentrations (5 μM to 25 μM), curcumin, along with a proper nanoparticle drug delivery carrier, may selectively kill bone cancer cells over healthy bone cells.
Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
Run
R
Chang
Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
Linlin
L
Sun
Department of Chemical Engineering, Northeastern University, Boston, MA, USA ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia.
Thomas J
TJ
Webster
D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects*; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology*
D003474:Curcumin
bone cancer; curcumin; human osteoblast; osteosarcoma; viability