Kinetochore signalling: the KIss that MELTs Knl1.
Mitotic kinetochores coordinate chromosome bi-orientation and anaphase onset by serving as scaffolds for the recruitment of regulatory proteins. Three new studies reveal that multiple interaction motifs of the kinetochore protein Knl1 cooperate to assemble signaling complexes that regulate chromosome segregation.
Laboratory of Biosignaling and Therapeutics, KU Leuven Department of Cellular and Molecular Medicine, University of Leuven, B-3000 Leuven, Belgium. Electronic address: Mathieu.Bollen@med.kuleuven.be.
Mathieu
M
Bollen
D020090:Chromosome Segregation / Q000502:physiology*; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism* / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism*
D008869:Microtubule-Associated Proteins