Maternal antibodies by passive immunization with formalin inactivated respiratory syncytial virus confer protection without vaccine-enhanced disease.
Maternal immunization of mice with formalin inactivated respiratory syncytial virus (FI-RSV) resulted in the passive transfer of RSV antibodies but not cellular components to the offspring. The offspring born to FI-RSV immunized mothers showed serum RSV neutralizing activity, effectively controlled lung viral loads without vaccine-enhanced disease, did not induce pulmonary eosinophilia, and cytokine producing cells after live RSV infection. Therefore, this study provides evidence that maternal immunization provides an in vivo model in investigating the roles of antibodies independent of cellular components.
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Young-Man
YM
Kwon
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Hye Suk
HS
Hwang
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Jong Seok
JS
Lee
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Eun-Ju
EJ
Ko
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Si-Eun
SE
Yoo
Animal and Plant Quarantine Agency, Anyang, Gyeonggi-do, South Korea.
Min-Chul
MC
Kim
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Yu-Na
YN
Lee
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA.
Ki-Hye
KH
Kim
Department of Global Medical Science, Sungshin Women's University, Seoul, South Korea.
Jae-Min
JM
Song
Department of Pediatrics, Emory University, Atlanta, GA 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA.
Sujin
S
Lee
Department of Pediatrics, Emory University, Atlanta, GA 30322, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA.
Martin L
ML
Moore
Center for Inflammation, Immunity & Infection, and Department of Biology, Georgia State University, Atlanta, GA 30303, USA. Electronic address: skang24@gsu.edu.
Sang-Moo
SM
Kang
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D007112:Immunity, Maternally-Acquired; D008168:Lung / Q000276:immunology / Q000473:pathology / Q000821:virology; D051379:Mice; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D016207:Cytokines; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
FI-RSV; Maternal antibodies; Passive immunization; Vaccine enhanced disease