Tigecycline susceptibility in multidrug resistant Acinetobacter isolates from Turkey.
The present study aimed to evaluate antimicrobial activity of tigecydcline against 84 multidrug resistant (MDR) Acinetobacter spp. strains by disc diffusion and E-test methods. The results of disc diffusion test were compared according to two different interpretation ways. In addition, E-test results and the disc diffusion results that interpreted by both the methods were checked for compatibility. According to the disc diffusion test, 3 strains (3.57%) were found resistant to tigecycline when considering breakpoints suggested by Food and Drug Administration (FDA). On the other hand, none of the strains was found resistant to the evaluation criteria recommended by Jones etal. (2007). Considering E-test results of tigecycline, MIC, and MICG, values of tigecycline for Acinetobacter spp. were 0.75 and 1 mg/l, respectively. Based on FDA defined breakpoints for Enterobacteriaceae, any resistant isolate was detected. In conclusion, although there are some differences in the results, tigecycline was found quite effective on Acinetobacter spp. isolates with reference to the both disc diffusion and the E-test methods.
Ege University Faculty of Pharmacy, Dep. of Pharmaceutical Microbiology, Izmir, Türkiye. fetferday@gmail.com
Fethiye Ferda
FF
Yilmaz
Ege University Faculty of Pharmacy, Dep. of Pharmaceutical Microbiology, Izmir, Türkiye.
Hüseyin
H
Taşli
lzmir Katip Celebi University, Atatürk Training and Research Hospital Medical Microbiology Laboratory, Izmir, Türkiye.
Süreyya
S
Gül-Yurtsever
Ege University Faculty of Pharmacy, Dep. of Pharmaceutical Microbiology, Izmir, Türkiye.
Ayça
A
Büyük
Ege University Faculty of Pharmacy, Dep. of Pharmaceutical Microbiology, Izmir, Türkiye.
Mine
M
Hoşgör-Limoncu
D000150:Acinetobacter / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D000151:Acinetobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D005838:Genotype; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078304:Tigecycline; D014421:Turkey / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline