Inhibition of death receptor signaling by bacterial gut pathogens.
Gastrointestinal bacterial pathogens such as enteropathogenic Escherichia coli, Salmonella and Shigella control inflammatory and apoptotic signaling in human intestinal cells to establish infection, replicate and disseminate to other hosts. These pathogens manipulate host cell signaling through the translocation of virulence effector proteins directly into the host cell cytoplasm, which then target various signaling pathways. Death receptors such as TNFR1, FAS and TRAIL-R induce signaling cascades that are crucial to the clearance of pathogens, and as such are major targets for inhibition by pathogens. This review focuses on what is known about how bacterial gut pathogens inhibit death receptor signaling to suppress inflammation and prevent apoptosis.
Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia.
Cristina
C
Giogha
Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia.
Tania Wong Fok
TW
Lung
Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia.
Jaclyn S
JS
Pearson
Department of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Victoria 3010, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria 3052, Australia. Electronic address: hartland@unimelb.edu.au.
Elizabeth L
EL
Hartland
D017209:Apoptosis / Q000276:immunology; D058947:Bacterial Secretion Systems / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D041981:Gastrointestinal Tract / Q000276:immunology* / Q000382:microbiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D064307:Microbiota / Q000276:immunology; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D053218:Receptors, Death Domain / Q000037:antagonists & inhibitors* / Q000276:immunology*; D012475:Salmonella / Q000276:immunology; D012760:Shigella / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology
D058947:Bacterial Secretion Systems; D016328:NF-kappa B; D053218:Receptors, Death Domain
Apoptosis; Bacterial pathogens; Death receptor; Inflammation; T3SS effectors