Paper microfluidics goes digital.
The first example of so-called "digital microfluidics" (DMF) implemented on paper by inkjet printing is reported. A sandwich enzyme-linked immunosorbent assay (ELISA) is demonstrated as an example of a complex, multistep protocol that would be difficult to achieve with capillary-driven paper microfluidics. Furthermore, it is shown that paper-based DMF devices have comparable performance to traditional photolithographically patterned DMF devices at a fraction of the cost.
Institute for Biomaterials and Biomedical Engineering, University of Toronto, 164 College St., Toronto, ON, M5S 3E1, Canada.
Ryan
R
Fobel
Andrea E
AE
Kirby
Alphonsus H C
AH
Ng
Ramin R
RR
Farnood
Aaron R
AR
Wheeler
D016287:Computer Peripherals; D004209:Disposable Equipment; D004797:Enzyme-Linked Immunosorbent Assay / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D008904:Miniaturization; D010209:Paper; D066330:Printing, Three-Dimensional; D011934:Reagent Strips; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*
D011934:Reagent Strips
diagnostics; digital microfluidics; electrowetting; enzyme-linked immunosorbent assay (ELISA); paper