Treatment of obesity with the resveratrol-enriched rice DJ-526.
Obesity is the most prevalent disease in the world which poses a serious risk for various chronic diseases. However, currently there are not any therapeutic agents that reduce body weight without causing serious side effects. In order to prevent and/or treat obesity and related diseases through a nutraceutical approach, we created a resveratrol-enriched transgenic rice accumulating 1.4 μg/g of resveratrol in its grain, DJ-526. Feeding of mice with the resveratrol-enriched rice DJ-526 showed excellent anti-obesity effect with reduction of body weights and abdominal fat volumes compared to the control by 20.0% and 31.3%, respectively. Also, the consumption of the resveratrol-enriched rice DJ526 significantly improved the blood lipid profiles and glucose levels in the animal experiments. Our resveratrol-enriched rice DJ-526 rice could provide both safe and convenient way for people with obesity and related diseases without major change of lifestyle or unwanted side effects from medication.
1] National Institute of Crop Science, Rural Development Administration, Iksan, Chonbuk, Korea [2].
So-Hyeon
SH
Baek
1] Department of Biomedical Sciences, Chonbuk National University Medical School, Jeonju, Chonbuk, Korea [2].
Hea-Jong
HJ
Chung
1] Department of Biomedical Sciences, Chonbuk National University Medical School, Jeonju, Chonbuk, Korea [2].
Heui-Kwan
HK
Lee
Department of Biomedical Sciences, Chonbuk National University Medical School, Jeonju, Chonbuk, Korea.
Roshan
R
D'Souza
Department of Biomedical Sciences, Chonbuk National University Medical School, Jeonju, Chonbuk, Korea.
Youngju
Y
Jeon
JINIS BDRD institute, JINIS Biopharmaceuticals Co., 948-9 Dunsan, Bongdong, Wanju 565-902, Jeollabuk-do, South Korea.
Hyeon-Jin
HJ
Kim
National Academy of Agricultural Science, Rural Development Administration, Suwon, Gyeonggi, Korea.
Soon-Jong
SJ
Kweon
Department of Biomedical Sciences, Chonbuk National University Medical School, Jeonju, Chonbuk, Korea.
Seong-Tshool
ST
Hong
D050153:Abdominal Fat; D000818:Animals; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D002851:Chromatography, High Pressure Liquid; D005260:Female; D008055:Lipids / Q000097:blood; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000178:diet therapy*; D012275:Oryza / Q000737:chemistry*; D030821:Plants, Genetically Modified; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*
D019440:Anti-Obesity Agents; D001786:Blood Glucose; D008055:Lipids; D013267:Stilbenes; D000077185:Resveratrol