Teaching neuroimages: neonatal parechovirus encephalitis: typical MRI findings.
A full-term 9-day-old girl presented with fever, irritability, and seizures. The routine CSF examination, cranial ultrasound, and laboratory tests were normal. Brain MRI showed diffuse white matter abnormality (figure). Human parechovirus (HPeV) type 3 was isolated in both CSF and blood. The neurodevelopmental outcome at 4 months is poor, and MRI shows an extensive cystic leukomalacia in the frontal white matter.
From the Departments of Neurosciences (V.B.) and Neonatology (P.B., R.B., M.B.), S. Anna Hospital, Como, Italy.
Vincenzo
V
Belcastro
Paolo
P
Bini
Roberta
R
Barachetti
Mario
M
Barbarini
D004660:Encephalitis / Q000209:etiology* / Q000473:pathology / Q000821:virology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D056784:Leukoencephalopathies / Q000209:etiology* / Q000473:pathology / Q000821:virology; D008279:Magnetic Resonance Imaging / Q000379:methods; D059906:Neuroimaging / Q000379:methods; D009462:Neurology / Q000193:education; D030061:Parechovirus / Q000472:pathogenicity*; D010850:Picornaviridae Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000473:pathology