High-intensity focused ultrasound treatment of late-stage pancreatic body carcinoma: optimal tumor depth for safe ablation.
Objective criteria are currently not available for assessing the extent of ablation by high-intensity focused ultrasound (HIFU). A retrospective review was conducted in Chinese patients with late-stage pancreatic body carcinoma treated with 1 h/d intermittent HIFU at a single center. Clinical and procedure-related characteristics were examined in relation to tumor posterior depth. Clinically, tumor ablation was negatively correlated with posterior tumor depth, with a 1-cm increase in depth decreasing ablation by 30.7%. At a computed tomography (CT)-determined 7-cm posterior tumor depth (considered the critical value for the procedure), ablation sensitivity and specificity were 77.8% and 72.7%, respectively. Tumor ablation >30% in patients with a CT-determined posterior tumor depth ≤7 cm was 9.333 times better than that in patients with a CT-determined posterior tumor depth >7 cm. Adverse effects did not affect the efficacy of HIFU. Tumors with posterior depths <7 cm may effectively be treated with HIFU-induced ablation with minimal adverse events.
Department of Ultrasound, Peking University Third Hospital, Haidian District, Beijing, China.
Hui-Yu
HY
Ge
Department of Ultrasound, Peking University Third Hospital, Haidian District, Beijing, China. Electronic address: ghyzmw@163.com.
Li-Ying
LY
Miao
Department of Urology, Peking University People's Hospital, Xicheng District, Beijing, China. Electronic address: xiongliulin@sina.com.
Liu-Lin
LL
Xiong
Clinic Epidemiology Research Group, Beijing Anding Hospital, Capital Medical University, Xicheng District, Beijing, China.
Fang
F
Yan
Department of Ultrasound, Peking University Third Hospital, Haidian District, Beijing, China.
Cui-Shan
CS
Zheng
Department of Ultrasound, Peking University Third Hospital, Haidian District, Beijing, China.
Jin-Rui
JR
Wang
Department of Ultrasound, Peking University Third Hospital, Haidian District, Beijing, China.
Jian-Wen
JW
Jia
Department of Ultrasound, Peking University Third Hospital, Haidian District, Beijing, China.
Li-Gang
LG
Cui
Department of Ultrasound, Peking University Third Hospital, Haidian District, Beijing, China.
Wen
W
Chen
D000368:Aged; D000369:Aged, 80 and over; D002681:China; D005260:Female; D057086:High-Intensity Focused Ultrasound Ablation / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000000981:diagnostic imaging / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D061214:Patient Safety; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D014463:Ultrasonography
Ablation; Carcinoma; Computed tomography; Depth; High-intensity focused ultrasound; Pancreatic cancer; Safety profile; Ultrasound