Clinical and laboratory parameters associated with metabolic syndrome in Turkish patients with psoriasis.
OBJECTIVE
To assess clinical and laboratory parameters associated with metabolic syndrome in Turkish patients with moderate or severe plaque-type psoriasis and nonpsoriatic controls.


METHODS
Patients with moderate or severe plaque psoriasis (patient group) or with nonpsoriatic dermatological disease (controls) were included. Waist circumference, weight, height and arterial blood pressure were measured, together with fasting blood glucose, triglyceride, high density lipoprotein (HDL), fibrinogen, homocysteine and adiponectin levels. Metabolic syndrome was diagnosed using National Cholesterol Education Program-Adult Treatment Panel III criteria.


RESULTS
Out of 90 patients (50 with psoriasis; 40 controls), metabolic syndrome was more frequent in the patient group than in controls. In terms of metabolic syndrome parameters, only hypertension was more frequent in patients with psoriasis compared with controls. There was no statistically significant difference between the patient and control groups for obesity, hypertriglyceridaemia, HDL levels or hyperglycaemia. Fibrinogen levels were increased and adiponectin levels were decreased in the psoriasis group. No between-group difference in homocysteine levels was found.


CONCLUSIONS
In this small study, metabolic syndrome was found to be more frequently identified in Turkish patients with psoriasis than in controls; metabolic syndrome could lead to increased cardiovascular disease risk in patients with moderate to severe psoriasis.
Department of Dermatology, School of Medicine, Research and Trainign Hospital, Gaziantep University, Gaziantep, Turkey.
Cenk
C
Akcali
Burcin
B
Buyukcelik
Necmettin
N
Kirtak
Serhat
S
Inaloz
D052242:Adiponectin / Q000097:blood; D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000453:epidemiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood; D015228:Hypertriglyceridemia / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D009765:Obesity / Q000150:complications*; D011565:Psoriasis / Q000150:complications* / Q000276:immunology; D014280:Triglycerides / Q000097:blood; D014421:Turkey / Q000453:epidemiology
D052242:Adiponectin; D008075:Lipoproteins, HDL; D014280:Triglycerides; D005340:Fibrinogen
Psoriasis; adiponectin; fibrinogen; metabolic syndrome