Hyperleptinemia is associated with CRP, but not apolipoprotein E, and is reduced by exercise training.
The purpose of this study was to examine whether leptin levels affect the response of leptin to exercise training (ET) and whether this is also affected by C-reactive protein (CRP) or the three common Apolipoprotein E genotypes (APOE). Ninety-seven (male = 45, female = 52) sedentary individuals underwent 6 months of supervised ET. Blood was sampled before the initiation of ET, and again 24 and 72 hr after completion of the final training session. ET resulted in a small reduction in body mass (80.47 ± 18.03 vs 79.42 ± 17.34 kg, p < .01). Leptin was reduced 24 hr after the final exercise session (p < .01), but returned to normal after 72 hr (p > .05)--Pre: 13.51 ± 12.27, 24hr: 12.14 ± 12.34, 72 hr: 12.98 ± 11.40 ng/ml. The most hyperleptinemic individuals had a greater initial response, which was sustained through to 72 hr after the final session in the pooled study population (p < .01), and in both males (p < .05) and females (p < .05) separately. CRP was related to leptin independently of body weight and positively related to the reductions in leptin. APOE genotype was not related to leptin levels and did not affect the response to ET. Leptin levels may only be reduced by ET in those with hyperleptinemia. In addition, both the initial extent of hyperleptinemia and the subsequent reduction in leptin may be related to low grade chronic systemic inflammation.
Dept. of Health Professions, University of Central Florida, Orlando, FL.
Joshua
J
Lowndes
Robert F
RF
Zoeller
George E
GE
Kyriazis
Mary P
MP
Miles
Richard L
RL
Seip
Niall M
NM
Moyna
Paul
P
Visich
Linda
L
Pescatello
Paul
P
Gordon
Paul D
PD
Thompson
Theodore J
TJ
Angelopoulos
D000328:Adult; D001057:Apolipoproteins E / Q000235:genetics*; D001835:Body Weight / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism*; D015444:Exercise / Q000502:physiology; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D064797:Physical Conditioning, Human / Q000502:physiology*; D057185:Sedentary Behavior
D001057:Apolipoproteins E; D020738:Leptin; D002097:C-Reactive Protein