[Quality of life and problems posed by hypoglycemia in type 2 diabetes mellitus during oral hypoglycemic therapy].
Quality of life characteristics, hypoglycemic episodes and patients' attitude toward them were estimated in the patients with type 2 diabetes mellitus based on the modern recommendations for the patient-oriented treatment with metformin in combination with sulfonylurea derivatives (M+S) therapy, traditional approach, n = 83) and metformin in combination with vildagliptin (M+V therapy, innovative approach, n = 111). M+V therapy ensured a higher quality of life than M+S therapy based on all SF-36 scales. Quality of life parameters corresponded to population norms in most patients given M+V therapy and only in 52% of those treated with M+S. The frequency of hypoglycemic episodes, related concerns, and other problems associated with this condition were less apparent in case of M+V therapy. Transition from M+S to M+V therapy resulted in the improvement of quality of life and reduction in the frequency of hypoglycemia. Quality of life did not change after transition to M+S therapy while the frequency of hypoglycemia and the number of related problems increased. HbA1c levels were similar in both groups (0.8% difference). According to patients' reports M+V therapy is more efficient than M+S; these data allow to comprehensively evaluate the efficacy of therapy and monitor the health state of diabetic patients in the course of treatment.
T I
TI
Ionova
V I
VI
Odin
T P
TP
Nikitina
K A
KA
Kurbatova
N E
NE
Shablovskaia
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced / Q000523:psychology*; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011788:Quality of Life
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents