A new dihydroagarofuranoid sesquiterpene from the roots of Tripterygium hypoglaucum.
A new sesquiterpene ester (1) has been isolated from the root bark of Tripterygium hypoglaucum. The structure was determined as 1α-acetoxy-6β,9β-dibenzoyloxy-4β-hydroxy-dihydroagarofuran by the extensive analysis of NMR data, and the absolute configurations were established as 1R, 4R, 6S, and 9R by application of the CD excitation chirality method. Compound 1 exhibited weak cytotoxicity against HeLa cells, with an IC₅₀ value of 30.2 μM.
a Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College , Beijing , 100193 , China.
Zhen-Zhen
ZZ
Liu
Rong-Hua
RH
Zhao
Yue-Tao
YT
Liu
Hong-Wu
HW
Zhang
Gang
G
Ding
Zhuo
Z
Ma
Zhong-Mei
ZM
Zou
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029757:Tripterygium / Q000737:chemistry*
C587305:1alpha-acetoxy-6beta,9beta-dibenzoyloxy-4beta-hydroxy-dihydroagarofuran; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C079978:dihydroagarofuran