Serum profiling of healthy aging identifies phospho- and sphingolipid species as markers of human longevity.
As centenarians well represent the model of healthy aging, there are many important implications in revealing the underlying molecular mechanisms behind such successful aging. By combining NMR metabonomics and shot-gun lipidomics in serum we analyzed metabolome and lipidome composition of a group of centenarians with respect to elderly individuals. Specifically, NMR metabonomics profiling of serum revealed that centenarians are characterized by a metabolic phenotype distinct from that of elderly subjects, in particular regarding amino acids and lipid species. Shot- gun lipidomics approach displays unique changes in lipids biosynthesis in centenarians, with 41 differently abundant lipid species with respect to elderly subjects. These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. Considering the particular actions of these metabolites, these data are suggestive of a better counteractive antioxidant capacity and a well-developed membrane lipid remodelling process in the healthy aging phenotype.
NESTEC SA, Nestlé Research Center, Vers-chez-les-Blanc, CH-1000 Lausanne 26, Switzerland.
Ivan
I
Montoliu
Max
M
Scherer
Fiona
F
Beguelin
Laeticia
L
DaSilva
Daniela
D
Mari
Stefano
S
Salvioli
Francois-Pierre J
FP
Martin
Miriam
M
Capri
Laura
L
Bucci
Rita
R
Ostan
Paolo
P
Garagnani
Daniela
D
Monti
Elena
E
Biagi
Patrizia
P
Brigidi
Martin
M
Kussmann
Serge
S
Rezzi
Claudio
C
Franceschi
Sebastiano
S
Collino
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000596:Amino Acids / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D008136:Longevity; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D055432:Metabolomics / Q000379:methods; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood*; D013107:Sphingolipids / Q000097:blood*
D000596:Amino Acids; D015415:Biomarkers; D010743:Phospholipids; D013107:Sphingolipids