Outlook for a dengue vaccine.
Dengue is an increasing medical problem in subtropical and tropical countries. The search for a safe and effective vaccine is complicated by the fact that there are four types of dengue virus and that, if a vaccine is live attenuated, it should be proven not to cause the life-threatening form of dengue, dengue haemorrhagic fever. So far one vaccine candidate, a four-valent chimeric vaccine constructed from a yellow fever vaccine strain, has reached large clinical trials and has been shown to offer protection against dengue types 1, 3 and 54 but not against dengue type 2. It is highly likely that an effective vaccine will be available in the next decade.
International Vaccine Institute, Seoul, Korea.
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D017326:Clinical Trials, Phase III as Topic; D003715:Dengue / Q000517:prevention & control*; D053059:Dengue Vaccines / Q000276:immunology*; D003716:Dengue Virus; D006801:Humans; D016032:Randomized Controlled Trials as Topic
D053059:Dengue Vaccines
Dengue; clinical trial; dengue epidemiology; dengue haemorrhagic fever; dengue vaccine