Polymeric implants for the delivery of green tea polyphenols.
Polymeric implants (millirods) have been tested for local delivery of chemotherapeutic agents in cancer treatment. Modeling of drug release profiles is critical as it may provide theoretical insights on rational implant design. In this study, a biodegradable poly (ε-caprolactone) (PCL) polymeric implant delivery system was tested to deliver green tea polyphenols (GTPs), both in vitro and in vivo. Factors including polymer compositions, supplements, drug loads, and surface area of implants were investigated. Our data showed that GTPs were released from PCL implants continuously for long durations, and drug load was the main determining factor of GTPs release. Furthermore, rates of in vitro release and in vivo release in the rat model followed similar kinetics for up to 16 months. A mathematical model was deduced and discussed. GTP implants have the potential to be used systemically and locally at the tumor site as an alternative strategy.
Department of Pharmacology and Toxicology, University of Louisville, Louisville, Kentucky, 40202.
Pengxiao
P
Cao
Jeyaprakash
J
Jeyabalan
Farrukh
F
Aqil
Srivani
S
Ravoori
Ramesh C
RC
Gupta
Manicka V
MV
Vadhanam
D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D063566:Biodegradable Plastics / Q000737:chemistry* / Q000378:metabolism; D028241:Camellia sinensis / Q000737:chemistry*; D002208:Caproates / Q000737:chemistry* / Q000378:metabolism; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D002839:Chromans / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D003505:Cyclodextrins / Q000737:chemistry / Q000378:metabolism; D004339:Drug Compounding; D004343:Drug Implants; D005260:Female; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism; D008970:Molecular Weight; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D018515:Plant Leaves / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry / Q000378:metabolism; D059808:Polyphenols / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics; D011409:Propylene Glycols / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D011912:Rats, Inbred ACI; D012995:Solubility; D013499:Surface Properties; D044366:Transition Temperature
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D063566:Biodegradable Plastics; D002208:Caproates; D002839:Chromans; D003505:Cyclodextrins; D004343:Drug Implants; D007783:Lactones; C116176:PEO-PPO-PEO; D010936:Plant Extracts; D059808:Polyphenols; D011409:Propylene Glycols; C527126:green tea extract polyphenone E; D011092:Polyethylene Glycols; C121056:caprolactone; D002392:Catechin
antioxidants; bioavailability; green tea polyphenols; in vitro/in vivo correlations; polymeric drug delivery systems; preclinical pharmacokinetics; toxicology