Antimicrobial resistance in Salmonella strains clinically isolated in Hyogo, Japan (2009-2012).
The purpose of this study was to examine the in vitro susceptibilities to antimicrobial agents and genetic diversity of 195 clinical strains of Salmonella spp., which were isolated and examined for the extended-spectrum β-lactamase (ESBL) blaCTX-M gene and the presence of gyrA, gyrB, parC, and parE genes mutations in Hyogo, Japan, from 2009 to 2012. Forty-three of the 195 strains were antimicrobial resistant. Two Salmonella enterica subsp. enterica strains, 1 serovar Schwarzengrund, and 1 serovar Enteritidis were identified as ESBL-producing strains possessing blaCTX-M-15 and blaCTX-M-2, respectively. Among 8 nalidixic acid-resistant strains, 7 had mutations in gyrA alone or in gyrA and parC. In conclusion, we identified CTX-M ESBL-producing Salmonella clinical strains with multidrug resistance. Further studies are needed to monitor these serious drug-resistant Salmonella strains in Japan.
Division of Infectious Diseases, Department of International Health, Kobe University Graduate School of Health Science.
Kayo
K
Osawa
Katsumi
K
Shigemura
Rika
R
Shimizu
Ayaka
A
Kato
Mayuha
M
Kimura
Yuki
Y
Katayama
Yuma
Y
Okuya
Shunichiro
S
Yutaka
Akiko
A
Nishimoto
Akane
A
Kishi
Miki
M
Fujiwara
Hiroyuki
H
Yoshida
Yoshio
Y
Iijima
Masato
M
Fujisawa
Toshiro
T
Shirakawa
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D007564:Japan; D008826:Microbial Sensitivity Tests; D012480:Salmonella Infections / Q000382:microbiology*; D019779:Salmonella enterica / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*
D000900:Anti-Bacterial Agents