Reversible posterior leukoencephalopathy syndrome during regorafenib treatment: a case report and literature review of reversible posterior leukoencephalopathy syndrome associated with multikinase inhibitors.
Division of Hematology/Oncology, Department of Medicine and the UVA Cancer Center, University of Virginia Health System, Charlottesville, VA. Electronic address: zm3p@virginia.edu.
Zaw W
ZW
Myint
Department of Pharmacy Services, University of Virginia Health System, Charlottesville, VA.
Jeremy M
JM
Sen
Department of Pharmacy Services, University of Virginia Health System, Charlottesville, VA.
Nicole L
NL
Watts
Division of Neuroradiology, Department of Radiology and Medical Imaging, University of Virginia Health System, Charlottesville, VA.
Thomas J
TJ
Druzgal
Department of Neurology, University of Virginia Health System, Charlottesville, VA.
Barnett R
BR
Nathan
Department of Neurology, University of Virginia Health System, Charlottesville, VA.
Melanie D
MD
Ward
Division of Hematology/Oncology, Department of Medicine and the UVA Cancer Center, University of Virginia Health System, Charlottesville, VA.
James E
JE
Boyer
Division of Hematology/Oncology, Department of Medicine and the UVA Cancer Center, University of Virginia Health System, Charlottesville, VA.
Paula M
PM
Fracasso
D020533:Angiogenesis Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D010671:Phenylurea Compounds / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000503:physiopathology; D011725:Pyridines / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D011725:Pyridines; C559147:regorafenib
Metastatic colorectal cancer; Posterior reversible encephalopathy; RPLS; Regorafenib; VEGF multikinase inhibitor; syndrome