[Comparison of the efficiency between in-vitro maturation and in-vitro fertilization after early follicular phase GnRH agonist down-regulation in infertile women with polycystic ovary syndrome].
OBJECTIVE
To compare the outcomes of in-vitro maturation (IVM) and in-vitro fertilization (IVF) after early follicular phase gonadotropin-releasing hormone agonist (GnRH-a) down-regulation in infertile patients with polycystic ovary syndrome (PCOS).


METHODS
From July 2010 to December 2012, 72 infertile patients with PCOS undergoing assisted reproductive technology treatment in the Affiliated First Hospital of Wenzhou Medical University were enrolled in this study. The patients were divided into 2 groups, which were patients with early follicular phase down-regulation IVM (36 cases) at IVM group and early follicular phase down-regulation long protocol IVF (36 cases) at IVF group. The laboratory parameters and clinical outcomes were compared between two groups.


RESULTS
(1) Lab parameters: a total of 442 oocytes were retrieved in group IVM, and 560 were in group IVF. The rate of mature oocytes of 83.8% (469/560) and high-quality embryos of 70.9% (212/299) at group IVF were significantly higher than that of group IVM[54.1% (239/442) and 50.7% (73/144), retrospectively, P < 0.01]. In group IVM, the average duration of gonadotropin (Gn) was (2.8 ± 1.5) days and the average dosage of Gn was (285 ± 169) U, which were significantly lower than (11.0 ± 1.0) days and (1499 ± 165) U in group IVF (P < 0.01). The mean number of oocytes retrieved 12.8 ± 2.5, fertilization rate of 64.8% (155/239), and implantation rate of 31% (23/74) in group IVM and 15.6 ± 3.1, 65.5% (307/469), 31% (23/74) in group IVF, which did not reach statistical difference (P > 0.05) . (2) Clinical outcomes: the clinical pregnancy rate (17/31, 55%) of IVF group was not significantly higher than that 44% (14/32) at IVM group (P > 0.05). The abortion rate was 1/17 at Group IVF and 1/14 in group IVM, which did not show statistical difference. Women at IVM group has no ovarian hyper-stimulation syndrome (OHSS) cycle, group IVF has 31% (11/36) cycles presented moderate and severe OHSS.


CONCLUSIONS
Infertile patients with PCOS undergoing IVM and IVF treatment after early follicular phase GnRH-a down-regulation can get satisfactory laboratory and clinical outcome. In addition to short treatment cycle, IVM can also avoid the occurrence of OHSS completely, but it has a rising trend in the abortion rate. IVF has a high incidence of OHSS, meanwhile, it increases the dosage of gonadotropins.
Reproductive Medicine Center, Affiliated First Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Ru-ru
RR
Zhu
Reproductive Medicine Center, Affiliated First Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Shi-quan
SQ
Xiao
Reproductive Medicine Center, Affiliated First Hospital of Wenzhou Medical University, Wenzhou 325000, China. Email: z.joyce08@163.com.
Jun-zhao
JZ
Zhao
Reproductive Medicine Center, Affiliated First Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Jia
J
Lin
Reproductive Medicine Center, Affiliated First Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Pei-yu
PY
Wang
Reproductive Medicine Center, Affiliated First Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Cong-cong
CC
Jin
Reproductive Medicine Center, Affiliated First Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Wu-min
WM
Jin
D000328:Adult; D002478:Cells, Cultured; D015536:Down-Regulation; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000819:agonists*; D006062:Gonadotropins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques / Q000379:methods*; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D009865:Oocytes / Q000187:drug effects / Q000254:growth & development*; D016471:Ovarian Hyperstimulation Syndrome / Q000453:epidemiology / Q000517:prevention & control; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone