Seven imported histoplasmosis cases due to Histoplasma capsulatum var. capsulatum: From few weeks to more than three decades asymptomatic period.
Histoplasma capsulatum is a nonendemic fungus in Europe. Epidemiological, clinical biological features and follow-up of seven imported cases in France were reported. These cases underlined the difficulties of such diagnosis in nonendemic areas due to greatly variable asymptomatic period, and lack of specific clinical signs. Thus, anamnesis should be carefully analysed; mucocutaneous signs and immunosuppression should be systematically investigated. Biological diagnosis requires multiple sites sampling and long-term conservation of culture medium.
Laboratoire de parasitologie-mycologie, centre hospitalier universitaire de Nîmes, université Montpellier-I, place du Pr.-Debré, 30029 Nîmes cedex 9, France.
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Bourgeois
Laboratoire de bactériologie, centre hospitalier universitaire de Nîmes, place du Pr. Robert-Debré, 30029 Nîmes, France.
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Douard-Enault
Service des maladies infectieuses et tropicales, centre hospitalier universitaire de Montpellier, université Montpellier I, 80, avenue Augustin-Fliche, 34295 Montpellier cedex 5, France.
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Reynes
Service de maladies infectieuses et tropicales, centre hospitalier universitaire de Nîmes, place du Pr. Robert-Debré, 30029 Nîmes, France.
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Lechiche
Laboratoire de parasitologie-mycologie, centre hospitalier universitaire de Montpellier, université Montpellier I, 39, avenue Charles-Flahault, 34095 Montpellier cedex 5, France.
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Basset
Laboratoire de parasitologie-mycologie, centre hospitalier universitaire de Montpellier, université Montpellier I, 39, avenue Charles-Flahault, 34095 Montpellier cedex 5, France.
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Rispail
Laboratoire de parasitologie-mycologie, centre hospitalier universitaire de Nîmes, université Montpellier-I, place du Pr.-Debré, 30029 Nîmes cedex 9, France.
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Lachaud