Tandem sp3 C-H functionlization/decarboxylation of 2-alkylazaarenes with coumarin-3-carboxylic acids.
The catalyst-free sp(3) C-H functionalization of 2-alkylazaarenes has been achieved in the reaction with (thio)coumarin-3-carboxylic acids. Followed by a tandem decarboxylation, this method provides facile synthesis of biologically important azaarene-substituted 3,4-dihydro(thio)coumarins in a single step in high yields.
College of Chemistry and Pharmaceutical Sciences, Qingdao Agricultural University , Qingdao 266109, China.
Lubin
L
Xu
Zhuzhou
Z
Shao
Liang
L
Wang
Jian
J
Xiao
D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D003374:Coumarins / Q000737:chemistry*; D003653:Decarboxylation; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D001372:Aza Compounds; D003374:Coumarins; D013438:Sulfhydryl Compounds; C104227:coumarin-3-carboxylic acid