Uveal effusion as a mechanism of bilateral angle-closure glaucoma induced by chlorthalidone.
OBJECTIVE
To report a novel case of acute bilateral uveal effusions, angle closure, and acute myopia induced by administration of chlorthalidone.


METHODS
Case report.


RESULTS
Bilateral shallow anterior chambers, high intraocular pressure, and a myopic shift were encountered in a patient 1 week after initiation of chlorthalidone. Ultrasound evaluation revealed bilateral ciliochoroidal effusions, appositional angle closure, and suspected ciliary body edema. Cessation of chlorthalidone, in addition to administration of cycloplegics and ocular antihypertensives, resulted in prompt resolution of this idiosyncratic reaction.


CONCLUSIONS
The antihypertensive medication chlorthalidone may cause bilateral uveal effusions inducing acute angle-closure glaucoma and acute myopia.
*Department of Ophthalmology Michigan State University, East Lansing †Metro Health Hospital, Wyoming, MI.
James R
JR
Singer
Zachary D
ZD
Pearce
Scott J
SJ
Westhouse
Karl J
KJ
Siebert
D000208:Acute Disease; D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002752:Chlorthalidone / Q000009:adverse effects*; D004232:Diuretics / Q000627:therapeutic use; D005260:Female; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D033401:Microscopy, Acoustic; D009184:Mydriatics / Q000008:administration & dosage; D009216:Myopia / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D014603:Uveal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D014792:Visual Acuity / Q000187:drug effects
D000959:Antihypertensive Agents; D004232:Diuretics; D009184:Mydriatics; D002752:Chlorthalidone