An unprecedented Pd-catalyzed trans-addition of boronic acids to ynamides.
An unprecedented Pd-catalyzed trans-addition of boronic acids to ynamides has been reported, giving α,β-disubstituted enamides in high yields with excellent regio- and stereoselectivity. A possible mechanism involving the palladium carbene intermediate has been proposed to account for the unusual trans-addition.
Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China. gangguo@zjnu.cn.
Yuanfa
Y
Yang
Lina
L
Wang
Jieni
J
Zhang
Yali
Y
Jin
Gangguo
G
Zhu