Intensity of Free Radical Processes in Rat Liver under Type 2 Diabetes and Introduction of Epifamin.
The effect of epifamin on free radical processes, the activity of caspase-1 and -3, aconitate hydratase and citrate content in rat's liver at experimentally induced type 2 diabetes mellitus (T2DM) was studied. The action of epifamin at T2DM leads to a decrease in biochemiluminescence parameters, characterizing the intensity of free radical processes, and changes in aconitase activity and citrate level towards the control. Activities of caspase-1 and caspase-3 in the tissue decreased by a factor of 2.4 and 1.6 in comparison with the levels at the disease. Apparently, epifamin-mediated correction of the level of melatonin, providing a significant antioxidant effect, promotes positive action on the free radical homeostasis.
Voronezh State University, Universitetskaya pl., 1, Voronezh, Russia, 394006.
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Popova
Voronezh State University, Universitetskaya pl., 1, Voronezh, Russia, 394006.
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Agarkov
Voronezh State University, Universitetskaya pl., 1, Voronezh, Russia, 394006.
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Verevkin
aconitate hydratase; biochemiluminescence; citrate, caspase; epifamin; type 2 diabetes mellitusXXXX