Caveolin-1 in cell migration and metastasis.
Caveolin-1 is a member of the caveolin family that has been ascribed a dual role in cancer. In early stages of disease the protein functions predominantly as a tumor suppressor, whereas at later stages, caveolin-1 expression is associated with tumor progression and metastasis. Here, some mechanisms associated with caveolin-1-dependent tumor suppression will be briefly discussed before focusing on the role of this protein and particularly phosphorylation of tyrosine-14 in promoting cell migration, invasion and metastasis. Models are provided summarizing possible explanations for these dramatic changes in function, as well as mechanisms by which this may be achieved.
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Núñez-Wehinger
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Ortiz
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Díaz
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Díaz
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Lobos-González
Independencia 1027, Facultad de Medicina, Universidad de Chile, Santiago, Chile. aquest@med.uchile.cl.
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Quest
D000818:Animals; D051242:Caveolin 1 / Q000235:genetics / Q000378:metabolism*; D002465:Cell Movement / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics; D010766:Phosphorylation
D051242:Caveolin 1