Crystallization of DNA-capped gold nanoparticles in high-concentration, divalent salt environments.
The multiparametric nature of nanoparticle self-assembly makes it challenging to circumvent the instabilities that lead to aggregation and achieve crystallization under extreme conditions. By using non-base-pairing DNA as a model ligand instead of the typical base-pairing design for programmability, long-range 2D DNA-gold nanoparticle crystals can be obtained at extremely high salt concentrations and in a divalent salt environment. The interparticle spacings in these 2D nanoparticle crystals can be engineered and further tuned based on an empirical model incorporating the parameters of ligand length and ionic strength.
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853 (USA); Current Address: Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602 (Singapore). jt394@cornell.edu.
Shawn J
SJ
Tan
Jason S
JS
Kahn
Thomas L
TL
Derrien
Michael J
MJ
Campolongo
Mervin
M
Zhao
Detlef-M
DM
Smilgies
Dan
D
Luo
D020029:Base Pairing; D003460:Crystallization; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D008024:Ligands; D015636:Magnesium Chloride / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D009693:Nucleic Acid Hybridization; D009994:Osmolar Concentration; D012492:Salts / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry
D008024:Ligands; D012492:Salts; D015636:Magnesium Chloride; D012965:Sodium Chloride; D006046:Gold; D004247:DNA
DNA hybridization; DNA nanoparticles; DNA nanotechnology; crystallization; divalent salts