Catalytic enantioselective trifluoromethylthiolation of oxindoles using shelf-stable N-(trifluoromethylthio)phthalimide and a cinchona alkaloid catalyst.
The organocatalytic enantioselective trifluoromethylthiolation of oxindoles employing N-(trifluoromethylthio)phthalimide as a stable, easy to handle CF3S-source has been developed. Optically active products with a quaternary stereogenic center bearing a CF3S-group are obtained in good yields and with good to excellent enantioselectivities.
Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany. magnus.rueping@rwth-aachen.de.
Magnus
M
Rueping
Xiangqian
X
Liu
Teerawut
T
Bootwicha
Roman
R
Pluta
Carina
C
Merkens
D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D010797:Phthalimides / Q000737:chemistry*; D013237:Stereoisomerism
D002930:Cinchona Alkaloids; D007211:Indoles; D010797:Phthalimides