In vitro aceclofenac release from IPN matrix tablets composed of chitosan-tamarind seed polysaccharide.
This communication describes the formulation and in vitro evaluation of IPN matrix tablets of aceclofenac. IPN microparticles using chitosan and tamarind seed polysaccharide blend was prepared using glutaraldehyde as cross-linker. The drug entrapment efficiency and average particle size of these microparticles was found to be 91.97±1.30% and 498.12±38.67 μm, respectively. These IPN microparticles were characterized by scanning electron microscopy (SEM) and powder X-ray diffraction (P-XRD) study. These microparticles were compressed with tablet excipients through direct compression technique. These matrix tablets showed sustained aceclofenac release over 8 h. These matrix tablets might be helpful to minimize dosing frequency and reduction of various side effects during prolong period of treatment.
Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, W.B., India. Electronic address: janapharmacy@rediffmail.com.
Sougata
S
Jana
Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, W.B., India.
Kalyan Kumar
KK
Sen
Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, W.B., India.
Sanat Kumar
SK
Basu
D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000031:analogs & derivatives* / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D013607:Tablets; D029861:Tamarindus / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013607:Tablets; D004008:Diclofenac; D048271:Chitosan; C056498:aceclofenac
Chitosan; Matrix tablet; Tamarind seed polysaccharide