Transcriptional co-repressors and memory storage.
Epigenetic modifications are a central mechanism for regulating chromatin structure and gene expression in the brain. A wide array of histone- and DNA-modifying enzymes have been identified as critical regulators of neuronal function, memory formation, and as causative agents in neurodevelopmental and neuropsychiatric disorders. Chromatin modifying enzymes are frequently incorporated into large multi-protein co-activator and co-repressor complexes, where the activity of multiple enzymes is both spatially and temporally coordinated. In this review, we discuss negative regulation of gene expression by co-repressor complexes, and the role of co-repressors and their binding partners in neuronal function, memory, and disease.
Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104, USA.
Hannah
H
Schoch
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: abele@sas.upenn.edu.
Ted
T
Abel
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D056970:Co-Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D063185:Epigenetic Repression; D005786:Gene Expression Regulation; D006801:Humans; D008568:Memory; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009422:Nervous System Diseases / Q000201:enzymology / Q000378:metabolism; D009474:Neurons / Q000201:enzymology / Q000378:metabolism*; D056971:Nuclear Receptor Co-Repressor 1 / Q000235:genetics / Q000378:metabolism; D056985:Nuclear Receptor Co-Repressor 2 / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D056264:Sin3 Histone Deacetylase and Corepressor Complex; D014158:Transcription, Genetic
D056970:Co-Repressor Proteins; C539127:NCOR1 protein, human; C539130:NCOR2 protein, human; D009419:Nerve Tissue Proteins; D056971:Nuclear Receptor Co-Repressor 1; D056985:Nuclear Receptor Co-Repressor 2; C121019:RCOR1 protein, human; D012097:Repressor Proteins; C099683:SIN3A transcription factor; D056245:Mi-2 Nucleosome Remodeling and Deacetylase Complex; D056264:Sin3 Histone Deacetylase and Corepressor Complex
Chromatin remodeling; Co-repressor; Epigenetics; Memory; NCOR; SIN3A