Randomized clinical trial: the clinical effects of herb-partitioned moxibustion in patients with diarrhoea-predominant irritable bowel syndrome.
Objective. To explore the efficacy of Herb-partitioned moxibustion in treating IBS-D patients. Method. 210 IBS-D patients were randomly assigned on a 3 : 3 : 2 basis to group HM, group FM, or group PB for 4-week treatment. The change of GSRS total score at weeks 4 and 8, the changes of GSRS specific scores, and adverse events were evaluated. Results. Patients in group HM and group FM had lower GSRS total score at week 4 (1.98 ± 0.303, 2.93 ± 0.302 versus 3.73 ± 0.449) and at week 8 (2.75 ± 0.306, 3.56 ± 0.329 versus 4.39 ± 2.48) as compared with patients' score in group PB. However, there was no significant difference of GSRS total score between group HM and group FM. The effect of HM was significantly greater than that of orally taking PB in ameliorating the symptoms of rugitus (0.38 versus 0.59, P < 0.05), abdominal pain (0.28 versus 0.57, P < 0.01), abdominal distension (0.4 versus 0.7, P < 0.01), and increased passage of stools (0.06 versus 0.25, P < 0.01) at the end of treatment period. In the follow-up period, patients' therapeutic effect in group HM remained greater than that in group FM (in abdominal pain, abdominal distension, and increased passage of stools) and that in group PB (in loose stools). Conclusions. HM appears to be a promising, efficacious, and well-tolerated treatment for patients with IBS-D.
Shandong University of Traditional Chinese Medicine, Shandong, Jinan 250014, China.
Yu-Xia
YX
Ma
Shandong University of Traditional Chinese Medicine, Shandong, Jinan 250014, China.
Xiao
X
Liu
Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medicine University, Beijing 10010, China.
Cun-Zhi
CZ
Liu
Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medicine University, Beijing 10010, China.
Lin-Peng
LP
Wang
Qilu Hospital Affiliated to Shandong University, Shandong, Jinan 250012, China.
Gang
G
Guo
Shandong University of Traditional Chinese Medicine, Shandong, Jinan 250014, China.
Dong-Qing
DQ
Du
Shandong University of Traditional Chinese Medicine, Shandong, Jinan 250014, China.
Zhi-Lei
ZL
Wang
Shandong University of Traditional Chinese Medicine, Shandong, Jinan 250014, China.
Hong
H
Ma
Shandong University of Traditional Chinese Medicine, Shandong, Jinan 250014, China.
Ping
P
Qi
Shandong University of Traditional Chinese Medicine, Shandong, Jinan 250014, China.
Zhao-Feng
ZF
Li
Qianfoshan Hospital Affiliated to Shandong University, Shandong, Jinan 250014, China.
Yan-Ping
YP
Guo
Shandong University of Traditional Chinese Medicine, Shandong, Jinan 250014, China.
Hua-Qiang
HQ
Yi
Shandong University of Traditional Chinese Medicine, Shandong, Jinan 250014, China ; Shandong University of Traditional Chinese Medicine, University Science Park, Chang-Qing District, Jinan 250355, China.
Shu-Zhong
SZ
Gao