Parathyroid adenoma diagnosed on the basis of a giant cell tumor of parieto-occipital region and multifocal bone injuries.
Brown tumors are rare skeletal manifestations of hyperparathyroidism (HPT) that may mimic cancer metastases. Histopathologically, they are difficult to differentiate from other giant cell lesions. A case is presented of 41-year-old woman with giant cell tumor in parieto-occipital region with injury of external bone lamina, growing into the skull cavity. The mass was suspected of being neoplastic. Numerous osteolytic lesions in the skull skeleton and multifocal bone injuries were observed, also. Elevation in calcium (5.91 mEq/L) and parathormone (1188 ng/mL) concentrations and hypercalciuria (52 mEq/24 h) suggested the diagnosis of HPT initially manifesting as a brown tumor of the skull. Further exploration confirmed the existence of parathyroid adenoma as a cause of the disease. The key treatment for the condition was surgical excision of the adenoma followed by the normalization of parathyroid function and significant reduction in size of skull tumor and other lesions.
Department of Endocrinology, Diabetology and Isotope Therapy, Medical University Wroclaw, Poland. anna.bohdanowicz-pawlak@umed.wroc.pl.
Anna
A
Bohdanowicz-Pawlak
Department of Endocrinology, Diabetology and Isotope Therapy, Medical University Wroclaw, Poland.
Jadwiga
J
Szymczak
Department of Endocrinology, Diabetology and Isotope Therapy, Medical University Wroclaw, Poland.
Joanna
J
Jakubowska
Department of Endocrinology, Diabetology and Isotope Therapy, Medical University Wroclaw, Poland.
Diana
D
Jedrzejuk
Department of Orthopedics, Specialist Hospital, Wrocław, Poland.
Andrzej
A
Pawlak
Department of Endocrine Surgery, Wroclaw Medical University, Poland.
Tadeusz
T
Lukienczuk
Department of Endocrinology, Diabetology and Isotope Therapy, Medical University Wroclaw, Poland.
Marek
M
Bolanowski
D000236:Adenoma / Q000175:diagnosis*; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005870:Giant Cell Tumors / Q000175:diagnosis*; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications / Q000175:diagnosis*; D009777:Occipital Bone / Q000473:pathology; D010002:Osteitis Fibrosa Cystica / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D010282:Parathyroid Neoplasms / Q000175:diagnosis*; D010294:Parietal Bone / Q000473:pathology; D012888:Skull Neoplasms / Q000175:diagnosis*