TT Mutant Homozygote of Kruppel-like Factor 5 Is a Key Factor for Increasing Basal Metabolic Rate and Resting Metabolic Rate in Korean Elementary School Children.
We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR) and resting metabolic rate (RMR) and the inhibition of obesity in Korean children. A variation of KLF5 (rs3782933) was genotyped in 62 Korean children. Using multiple linear regression analysis, we developed a model to predict BMR in children. We divided them into several groups; normal versus overweight by body mass index (BMI) and low BMR versus high BMR by BMR. There were no differences in the distributions of alleles and genotypes between each group. The genetic variation of KLF5 gene showed a significant correlation with several clinical factors, such as BMR, muscle, low-density lipoprotein cholesterol, and insulin. Children with the TT had significantly higher BMR than those with CC (p = 0.030). The highest muscle was observed in the children with TT compared with CC (p = 0.032). The insulin and C-peptide values were higher in children with TT than those with CC (p= 0.029 vs. p = 0.004, respectively). In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p = 0.018, respectively), while Rohrer's index could explain the usual decrease in BMR (adjust r(2) = 1.000, p < 0.001, respectively). We identified a novel association between TT of KLF5 rs3782933 and BMR in Korean children. We could make better use of the variation within KLF5 in a future clinical intervention study of obesity.
Research Institute of Obesity Science, Sungshin Women's University, Seoul 142-137, Korea.
Jung Ran
JR
Choi
Laboratory Exercise Biochemistry, Korea National Sport University, Seoul 138-763, Korea. ; Department of Food and Nutrition, Sungshin Women's University, Seoul 142-137, Korea.
In-Su
IS
Kwon
Nutrition and Metabolism Research Group, Korea Food Research Institute, Seongnam 463-746, Korea.
Dae Young
DY
Kwon
Nutrition and Metabolism Research Group, Korea Food Research Institute, Seongnam 463-746, Korea.
Myung-Sunny
MS
Kim
Research Institute of Obesity Science, Sungshin Women's University, Seoul 142-137, Korea. ; Department of Food and Nutrition, Sungshin Women's University, Seoul 142-137, Korea.
Myoungsook
M
Lee
Kruppel-like factor 5 (KLF5); basal metabolic rate; body composition; predictive equations; resting metabolic rate (RMR)