Maternal exposure to bisphenol A may increase the risks of Parkinson's disease through down-regulation of fetal IGF-1 expression.
So far, the pathogenesis of Parkinson's disease (PD) remains unclear. Current studies implicate environmental toxins may be potential causes of fetal origin of PD. BPA is a member of the family of estrogenic chemicals existing widely in environment. Significant evidences from animal experimentation have demonstrated that BPA interfere with fetal neurodevelopment. Based on previous reports and our research on EB derived from hESCs, we speculate that maternal exposure to low-dose BPA during gestational period may decrease IGF-1 expression, thus hinder the development of fetal DA neurons, and finally increase the risks of fetal origin of PD. Our hypothesis may shed new light on the pathogenesis of PD and lead to potential preventive treatments.
Department of Life Science and Technology, China Pharmaceutical University, Nanjing 210038, China; State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Boxian
B
Huang
State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Chunyan
C
Jiang
State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Jian
J
Luo
State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
Yugui
Y
Cui
State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. Electronic address: lj_qin@sina.cn.
Lianju
L
Qin
Department of Life Science and Technology, China Pharmaceutical University, Nanjing 210038, China; State Key Laboratory of Reproductive Medicine, Clinical Center of Reproductive Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China. Electronic address: jyliu_nj@126.com.
Jiayin
J
Liu
D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D015536:Down-Regulation; D005260:Female; D005333:Fetus / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D018811:Maternal Exposure; D010300:Parkinson Disease / Q000209:etiology*; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D012307:Risk Factors; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D007334:Insulin-Like Growth Factor I; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds