Case fatality ratio and mortality rate trends of community-onset Staphylococcus aureus bacteraemia.
Lethal outcomes can be expressed as a case fatality ratio (CFR) or as a mortality rate per 100 000 population per year (MR). Population surveillance for community-onset methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) Staphylococcus aureus bacteraemia was conducted in Canada, Australia, Sweden and Denmark to evaluate 30-day CFR and MR trends between 2000 and 2008. The CFR was 20.3% (MSSA 20.2%, MRSA 22.3%) and MR was 3.4 (MSSA 3.1, MRSA 0.3) per 100 000 per year. Although MSSA CFR was stable the MSSA MR increased; MRSA CFR decreased while its MR remained low during the study. Community-onset S. aureus bacteraemia, particularly MSSA, is associated with major disease burden. This study highlights complementary information provided by evaluating both CFR and MR.
University of Calgary, Calgary, AB, Canada.
S
S
Tom
J C
JC
Galbraith
L
L
Valiquette
G
G
Jacobsson
P
P
Collignon
H C
HC
Schønheyder
M
M
Søgaard
K J
KJ
Kennedy
J D
JD
Knudsen
C
C
Ostergaard
O
O
Lyytikäinen
K B
KB
Laupland
D001315:Australia / Q000453:epidemiology; D016470:Bacteremia / Q000382:microbiology / Q000401:mortality*; D002170:Canada / Q000453:epidemiology; D017714:Community-Acquired Infections / Q000382:microbiology / Q000401:mortality; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D011159:Population Surveillance / Q000379:methods; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000401:mortality; D013211:Staphylococcus aureus / Q000145:classification*; D013548:Sweden / Q000453:epidemiology
Bacteraemia; case fatality; mortality; staphylococcus