Association between calcaneus quantitative ultrasound (QUS) parameters and thyroid status in middle-aged and elderly Chinese men with euthyroidism: a population-based cross-sectional study.
Although it is generally accepted that thyroid hormones affect bone metabolism, there is little data on the association of thyroid antibodies with bone status. We aimed to investigate the association between thyroid hormones or antibodies and quantitative ultrasound (QUS) parameters. This was a cross-sectional, population-based study conducted in Nanjing, China. A total of 1,001 Chinese men over 40 years were enrolled. We measured free triiodothyronine, free thyroxin (fT4), thyroid-stimulating hormone, anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin, 25-hydroxyvitamin D, and QUS parameters. After adjusting for potential confounders, QUS values decreased from the lowest to highest tertiles of fT4 in euthyroid men [quantitative ultrasound index (QUI) p = 0.002, broadband ultrasound attenuation (BUA) p = 0.000, speed of sound (SOS) p = 0.009, respectively]. Men with high anti-TPO levels (≥200 IU/ml) were found to have lower QUI (p = 0.030), BUA (p = 0.034), and SOS (p = 0.041) values than controls (<200 IU/ml). The prevalence of vitamin D deficiency was significantly higher in individuals with high anti-TPO than those in lower levels (87.5 vs. 59.5 %, p = 0.001). Our results suggest that high fT4 or anti-TPO values are associated with lower QUS parameters. Prospective studies are needed to confirm the precise relationship between thyroid status and osteoporosis.
Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
Yun
Y
Shi
Min
M
Sun
Zhixiao
Z
Wang
Qi
Q
Fu
Mengdie
M
Cao
Zhenxin
Z
Zhu
Chuchen
C
Meng
Jia
J
Mao
Yu
Y
Duan
Wei
W
Tang
Xiaoping
X
Huang
Jieli
J
Lu
Yufang
Y
Bi
Guang
G
Ning
Wei
W
He
Tao
T
Yang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D015519:Bone Density; D002111:Calcaneus / Q000000981:diagnostic imaging*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D006304:Health Status; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D033862:Iron-Binding Proteins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
D001323:Autoantibodies; D001324:Autoantigens; D033862:Iron-Binding Proteins; D013963:Thyroid Hormones; C006606:anti-thyroglobulin; D013972:Thyrotropin; C056658:TPO protein, human; D007453:Iodide Peroxidase