Carboxyl decorated Fe3O4 nanoparticles for MRI diagnosis and localized hyperthermia.
We report the development of carboxyl decorated iron oxide nanoparticles (CIONs) by a facile soft-chemical approach for magnetic resonance imaging (MRI) and hyperthermia applications. These superparamagnetic CIONs (~10 nm) are resistant to protein adsorption under physiological medium and exhibit good colloidal stability, magnetization and cytocompatibility with cell lines. Analysis of the T2-weighted MRI scans of CIONs in water yields a transverse relaxivity (r2) value of 215 mM(-1) s(-1). The good colloidal stability and high r2 value make these CIONs as promising candidates for high-efficiency T2 contrast agent in MRI. Further, these biocompatible nanoparticles show excellent self-heating efficacy under external AC magnetic field (AMF). The infrared thermal imaging confirmed the localized heating of CIONs under AMF. Thus, these carboxyl decorated Fe3O4 nanoparticles can be used as a contrast agent in MRI as well as localized heat activated killing of cancer cells. Furthermore, the active functional groups (COOH) present on the surface of Fe3O4 nanoparticles can be accessible for routine conjugation of biomolecules/drugs through well-developed bioconjugation chemistry.
Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India. Electronic address: kcbarick@barc.gov.in.
K C
KC
Barick
Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology Bombay, Mumbai 400076, India.
Sarika
S
Singh
Department of Metallurgical Engineering and Materials Science, Indian Institute of Technology Bombay, Mumbai 400076, India.
D
D
Bahadur
Department of MRI, Dr. Balabhai Nanavati Hospital and Research Centre, Mumbai 400056, India.
Malini A
MA
Lawande
Department of MRI, Dr. Balabhai Nanavati Hospital and Research Centre, Mumbai 400056, India.
Deepak P
DP
Patkar
Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400085, India. Electronic address: hassan@barc.gov.in.
P A
PA
Hassan
D000818:Animals; D001773:Blood Cells / Q000166:cytology / Q000187:drug effects; D002460:Cell Line; D003287:Contrast Media / Q000737:chemistry* / Q000494:pharmacology; D052203:Ferrosoferric Oxide / Q000737:chemistry* / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005456:Fluorescent Dyes; D005998:Glycine / Q000737:chemistry*; D006367:HeLa Cells; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D006979:Hyperthermia, Induced; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051379:Mice; D046529:Microscopy, Electron, Transmission; D012235:Rhodamines; D014961:X-Ray Diffraction
D003287:Contrast Media; D005456:Fluorescent Dyes; D058185:Magnetite Nanoparticles; D012235:Rhodamines; C022027:lissamine rhodamine B; D005998:Glycine; D052203:Ferrosoferric Oxide
Fe(3)O(4); Hyperthermia; MRI; Nanoparticles; Surface functionalization