Lichen sclerosus and the risk of malignant progression: a case series of 159 patients.
OBJECTIVE
We analyzed 159 stored specimens of Lichen Sclerosus (LS) collected in the period 1999-2011 from 159 patients, in order to evaluate the histological patterns, clinical outcomes and possible associations with malignancies. The histopathologic analysis revealed 145 cases (males and females) with LS alone, 7 in whom penile LS was associated with spinocellular carcinoma (SCC), and 7 in whom LS was associated with a pseudocarcinomatous-hyperplasia (PCH). Extragenital LS was found in 20% (17/85) of the males and 78% (58/74) of the females. In the cases of SCC, immunohistochemical analyses was performed.


CONCLUSIONS
The results showed very low positivity to p16INK4A and Ki-67; biomolecular PCR was positive in only two cases, and in both cases the non-oncogenic genotype HPV 100 was detected. No important additional risk factors for malignancies were found (e.g., hormones, infections, other autoimmune diseases).
Dermatopathological Unit San Gallicano Institute - IRCCS, Rome, Italy - paolgio@libero.it.
G
G
Paolino
C
C
Panetta
C
C
Cota
L
L
Muscardin
P
P
Donati
A
A
Di Carlo
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000032:analysis; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D018459:Lichen Sclerosus et Atrophicus / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000473:pathology* / Q000821:virology; D010412:Penile Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012878:Skin Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery
D014408:Biomarkers, Tumor; D019941:Cyclin-Dependent Kinase Inhibitor p16; D019394:Ki-67 Antigen