Solid and cystic papillary neoplasm of pancreas: A clinic-pathological and immunohistochemical study: A tertiary care center experience.
BACKGROUND
Solid pseudopapillary tumor of the pancreas (SPT) is a rare tumor of low malignant potential, mostly described in young women.


METHODS
In this retrospective study from January 2000 - December 2010, there were 50 pancreatic tumors. In this period, four SPTs were encountered, which were analyzed with respect to clinical, imaging, histopathological, and immunohistochemical findings.


RESULTS
There was a female preponderance with mean age of 22.2 years. Two of the tumors were located in head of the pancreas and two in the body and tail region. On imaging, majority were large cystic tumors. Histopathologically, they exhibited extensive necrosis and presence of pseudo papillae in viable areas. Immunohistochemically, they were positive for alpha-1-anti-trypsin, alpha-1-anti-chymotrypsin, vimentin, CD10, and CD99. Progesterone receptor and p53 exhibited mild positivity in all of the four cases, whereas neuron specific enolase (NSE), synaptophysin, and chromogranin showed focal positivity in one case.


CONCLUSIONS
Despite its non-specific clinical, imaging, and even immunohistochemical features, characteristic gross and microscopic findings provide reliable diagnosis of SPTs.
Department of Pathology, Sri Venkateswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Rashmi
R
Patnayak
Department of Surgical Oncology, Sri Venkateswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Amitabh
A
Jena
Department of Surgical Gastroenterology, Sri Venkateswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Sriram
S
Parthasarathy
Department of Radiology, Sri Venkateswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Bodagala
B
Vijaylaxmi
Department of Radiology, Sri Venkateswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Amancharla Y
AY
Lakshmi
Department of Pathology, Sri Venkateswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Nandyala
N
Rukmangadha
Department of Pathology, Sri Venkateswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Amit K
AK
Chowhan
Department of Pathology, Sri Venkateswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Bobbit V
BV
Phaneendra
Department of Pathology, Sri Venkateswar Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Mandyam K
MK
Reddy
Immunohistochemistry; pancreas; solid pseudopapillary tumor of the pancreas