Controlled release of protein from biodegradable multi-sensitive injectable poly(ether-urethane) hydrogel.
The synthesis and characterization of multi-sensitive polymers for use as injectable hydrogels for controlled protein/drug delivery is reported. A series of biodegradable multi-sensitive poly(ether-urethane)s were prepared through a simple one-pot condensation of poly(ethylene glycol), 2,2'-dithiodiethanol, N-methyldiethanolamine, and hexamethylene diisocyanate. The sol-gel phase transition behaviors of the obtained copolymers were investigated. Experimental results showed that the aqueous medium comprising the multi-segment copolymers underwent a sol-to-gel phase transition with increasing temperature and pH. At a certain concentration, the copolymer solution could immediately change to a gel under physiological conditions (37 °C and pH 7.4), indicating their suitability as in situ injectable hydrogels in vivo. Insulin was used as a model protein drug for evaluation of the injectable hydrogels as a site-specific drug delivery system. The controlled release of insulin from the hydrogel devices was demonstrated by degradation of the copolymer, which is modulated via the 2,2'-dithiodiethanol content in the poly(ether-urethane)s. These hydrogels having multi-responsive properties may prove to be promising candidates for injectable and controllable protein drug delivery devices.
Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, Nankai University , Tianjin 300071, China.
Xiaomeng
X
Li
Yangyun
Y
Wang
Jiaming
J
Chen
Yinong
Y
Wang
Jianbiao
J
Ma
Guolin
G
Wu
D001672:Biocompatible Materials / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D007328:Insulin / Q000737:chemistry* / Q000494:pharmacology; D011091:Polyesters / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D007328:Insulin; D011091:Polyesters; D011140:Polyurethanes; C081821:microthane foam; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate