Unifying immunology with informatics and multiscale biology.
The immune system is a highly complex and dynamic system. Historically, the most common scientific and clinical practice has been to evaluate its individual components. This kind of approach cannot always expose the interconnecting pathways that control immune-system responses and does not reveal how the immune system works across multiple biological systems and scales. High-throughput technologies can be used to measure thousands of parameters of the immune system at a genome-wide scale. These system-wide surveys yield massive amounts of quantitative data that provide a means to monitor and probe immune-system function. New integrative analyses can help synthesize and transform these data into valuable biological insight. Here we review some of the computational analysis tools for high-dimensional data and how they can be applied to immunology.
1] Department of Genetics and Genomic Sciences, New York, New York, USA. [2] Icahn Institute for Genomics and Multiscale Biology, New York, New York, USA. [3] Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Brian A
BA
Kidd
1] Icahn School of Medicine at Mount Sinai, New York, New York, USA. [2] Graduate School of Biomedical Sciences, New York, New York, USA.
Lauren A
LA
Peters
1] Department of Genetics and Genomic Sciences, New York, New York, USA. [2] Icahn Institute for Genomics and Multiscale Biology, New York, New York, USA. [3] Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Eric E
EE
Schadt
1] Department of Genetics and Genomic Sciences, New York, New York, USA. [2] Icahn Institute for Genomics and Multiscale Biology, New York, New York, USA. [3] Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Joel T
JT
Dudley
D000486:Allergy and Immunology; D000818:Animals; D055106:Genome-Wide Association Study; D057166:High-Throughput Screening Assays; D006801:Humans; D007107:Immune System; D008490:Medical Informatics / Q000379:methods*; D025341:Principal Component Analysis; D012107:Research Design; D049490:Systems Biology / Q000379:methods*