Chemoselective catalytic conjugate addition of alcohols over amines.
A highly chemoselective conjugate addition of alcohols in the presence of amines is described. The cooperative nature of the catalyst enabled chemoselective activation of alcohols over amines, allowing the conjugate addition to soft Lewis basic α,β-unsaturated nitriles. Divergent transformation of the nitrile functionality highlights the utility of the present catalysis.
Graduate school of Pharmaceutical Sciences, Kyushu University and CREST, JST, Maidashi Higashi-ku, Fukuoka, 812-8582 (Japan).
Shuhei
S
Uesugi
Zhao
Z
Li
Ryo
R
Yazaki
Takashi
T
Ohshima
D000438:Alcohols / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D058115:Lewis Bases / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D011522:Protons
D000438:Alcohols; D000588:Amines; D058115:Lewis Bases; D009570:Nitriles; D011522:Protons
amino alcohols; chemoselective catalysis; cooperative effects; proton transfer; synthetic methods