The Interleukin-18 promoter -607C>A polymorphism contributes to nasopharyngeal carcinoma risk: evidence from a meta-analysis including 1,886 subjects.
The interleukin-18 promoter -607C>A gene polymorphism may be related to nasopharyngeal carcinoma (NPC) risk but the results of individual studies remain conflicting. A meta-analysis including 1,886 subjects from five individual studies was therefore performed to provide a more accurate estimation. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were evaluated by fixed- or random-effects models. A significant relationship between interleukin-18 promoter -607C>A gene polymorphism and NPC was found in a dominant genetic model (OR: 1.351, 95% CI: 1.089-1.676, P=0.006, Pheterogeneity=0.904), a homozygote model (OR: 1.338, 95% CI: 1.023-1.751, P=0.034, Pheterogeneity=0.863), and a heterozygote model (OR: 1.357, 95% CI: 1.080-1.704, P=0.009, Pheterogeneity=0.824). No significant association was detected in either an allelic genetic model (OR: 1.077, 95% CI: 0.960-1.207, 0.207, Pheterogeneity=0.844) or a recessive genetic model (OR: 1.093, 95% CI: 0.878-1.361, P=0.425, Pheterogeneity=0.707). In conclusion, a significant association was found between interleukin-18 promoter -607C>A gene polymorphism and NPC risk. Individuals with the C allele of interleukin-18 promoter -607C>A gene polymorphism have a higher risk of NPC development.
Department of Clinical Laboratory Medicine, the Third affiliated Hospital of Guangzhou Medical University, Guangzhou, China E-mail : gysyxy@gmail.com.
Xu-Guang
XG
Guo
Yong
Y
Xia
D002277:Carcinoma; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000209:etiology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors
D020382:Interleukin-18