Circulating Th22 and Th9 levels in patients with acute coronary syndrome.
BACKGROUND
CD4+ T helper (Th) cells play critical roles in the development and progression of atherosclerosis and the onset of acute coronary syndromes (ACS, including acute myocardial infarction (AMI) and unstable angina pectoris (UAP)). In addition to Th1, Th2, and Th17 cells, Th22 and Th9 subsets have been identified in humans. In the present study, we investigated whether Th22 cells and Th9 cells are involved in the onset of ACS.


METHODS
The frequencies of Th22 and Th9 cells were detected using a flow cytometric analysis and their related cytokine and transcription factor were measured in the AMI, UAP, stable angina pectoris (SAP), and control groups.


RESULTS
The results revealed a significant increase in the peripheral Th22 number, AHR expression, and IL-22 levels in patients with ACS compared with those in the SAP and control groups. Although there was no difference in the peripheral Th9 number among the four groups, the PU.1 expression and IL-9 levels were significantly increased in patients with ACS compared with the SAP and control groups.


CONCLUSIONS
Circulating Th22 and Th9 type responses may play a potential role in the onset of ACS symptom.
Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Ying-zhong
YZ
Lin
Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Bang-wei
BW
Wu
Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Zheng-de
ZD
Lu
Department of Ultrasound, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Ying
Y
Huang
Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Ying
Y
Shi
Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Hao
H
Liu
Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Ling
L
Liu
Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qiu-tang
QT
Zeng
Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xiang
X
Wang
Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Qing-wei
QW
Ji
D054058:Acute Coronary Syndrome / Q000276:immunology*; D000368:Aged; D060050:Angina, Stable / Q000276:immunology; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016906:Interleukin-9 / Q000097:blood; D007378:Interleukins / Q000097:blood; D020935:MAP Kinase Signaling System; D008297:Male; D008875:Middle Aged; D011518:Proto-Oncogene Proteins / Q000032:analysis; D018336:Receptors, Aryl Hydrocarbon / Q000032:analysis; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology*; D015534:Trans-Activators / Q000032:analysis; D016277:Ventricular Function, Left; D000097043:Interleukin-22; D000099232:Proto-Oncogene Protein Spi-1
D016906:Interleukin-9; D007378:Interleukins; D011518:Proto-Oncogene Proteins; D018336:Receptors, Aryl Hydrocarbon; D015534:Trans-Activators; D000097043:Interleukin-22; D000099232:Proto-Oncogene Protein Spi-1