Intercellular adhesion molecule 1/2 and E-selectin in plasma cell mastitis: immunohistochemical study of 35 cases.
Plasma cell mastitis (PCM) is one of the most frequently encountered inflammatory diseases of the nonlactating breast. Histologically, PCM is characterized by infiltration of relatively abundant plasma cells into the mammary ducts. Its pathogenesis has remained unknown. In this study, we immunolocalized intercellular adhesion molecule (ICAM) 1 and 2 and E-selectin, all of which play pivotal roles in the inflammatory process, in 35 cases of PCM. We then compared the results with those of non-PCM and nonpathologic breast tissue. In the ductal epithelium, ICAM-1 immunoreactivity was significantly more pronounced in PCM than in non-PCM (P = .045). Both ICAM-1 (P < .001) and ICAM-2 (P = .001) were significantly more pronounced in PCM than in nonpathologic breast tissue. However, no significant differences in ICAM-2 and E-selectin immunoreactivity were detected between ductal epithelium of PCM and non-PCM. ICAM-1, but not ICAM-2 or E-selectin, demonstrated significantly higher immunoreactivity in endothelial cells of PCM than in nonpathologic breast (P < .001). These results all suggest that ICAM-1 in both ductal epithelium and endothelium plays important roles in the inflammatory process of PCM, possibly through margination, extravasation, and attachment of plasma cells and lymphocytes, which may result in continuous inflammatory cell homing to ductal epithelial cells.
Department of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan; Department of Surgical Oncology, Ningxia Medical University, Yinchuan, Ningxia, 750021, People's Republic of China; Department of Breast Surgery, Ningxia People's Hospital, Yinchuan, Ningxia, 750021, People's Republic of China.
Yu
Y
Dong
Department of Surgical Oncology, Ningxia Medical University, Yinchuan, Ningxia, 750021, People's Republic of China; Department of Breast Surgery, Ningxia People's Hospital, Yinchuan, Ningxia, 750021, People's Republic of China.
Jian-Jun
JJ
Yu
Department of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
Yukiko
Y
Shibahara
Department of Pathology, Ningxia People's Hospital, Yinchuan, Ningxia, 750021, People's Republic of China.
Huai-Sheng
HS
Lu
Department of Pathology, Ningxia People's Hospital, Yinchuan, Ningxia, 750021, People's Republic of China.
Hai-Yan
HY
He
Department of Pathology, Ningxia People's Hospital, Yinchuan, Ningxia, 750021, People's Republic of China.
Jian-Dong
JD
Liu
Department of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan; Department of Pathology, Second Hospital of Jilin University, Changchun, 130041, People's Republic of China.
Shi-Fan
SF
Chen
Department of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan; Department of Physiology, Harbin Medical University Daqing Branch, Daqing, 163319, People's Republic of China.
Lin
L
Wang
Division of Oral Physiology, Graduate School of Dentistry, Tohoku University, Sendai, Miyagi, 980-8575, Japan.
Ye
Y
Zhang
Department of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
Saulo J A
SJ
Felizola
Department of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
Monica S M
MS
Chan
Department of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
Katsuhiko
K
Ono
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
Takanori
T
Ishida
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan.
Noriaki
N
Ohuchi
Department of Pathology, Tohoku University, Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan. Electronic address: hsasano@patholo2.med.tohoku.ac.jp.
Hironobu
H
Sasano
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism*; D001940:Breast / Q000378:metabolism*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D019040:E-Selectin / Q000378:metabolism*; D042783:Endothelial Cells / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008413:Mastitis / Q000378:metabolism*; D010950:Plasma Cells / Q000378:metabolism*
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D019040:E-Selectin; C065289:ICAM2 protein, human; D018799:Intercellular Adhesion Molecule-1
Breast; Cell adhesion; Inflammation; Plasma cell mastitis