Oral hepatoprotective ability evaluation of purple sweet potato anthocyanins on acute and chronic chemical liver injuries.
In recent years, chemical liver injury cases increased significantly in Asian countries, and the imbalance in redox system was believed to be the main cause. Purple sweet potato anthocyanins (PSPA) have been shown to exert antioxidant activity and oxidative-stress-associated functional protein modulation through various signaling pathways, so it is considered to have the potential of liver injury preventive activity. In order to evaluate the hepatoprotective potency of PSPA according to its free radical scavenging and antioxidant effects, three acute chemical liver injury models were set up with ethanol, acetaminophen and carbon tetrachloride. PSPA at moderate and high doses obviously attenuated the tested serum biomarker levels and liver index in our experiments. Besides, one chronic liver injury model set up with carbon tetrachloride was also applied, in which PSPA was orally administrated after the liver damage had been formed. Both the serum biomarker levels and histopathological analysis showed that PSPA was able to attenuated chronic liver injury. Our experimental results demonstrated the potential of PSPA as an oral hepatoprotective agent against chemical liver injury from food plant.
Medical College of Qingdao University, 308 Ningxia Road, Qingdao, 266071, Shandong, People's Republic of China.
Wencheng
W
Wang
Jinlian
J
Li
Zhi
Z
Wang
Hui
H
Gao
Li
L
Su
Jing
J
Xie
Xuehong
X
Chen
Hui
H
Liang
Chunbo
C
Wang
Yantao
Y
Han
D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage* / Q000494:pharmacology*; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood; D002251:Carbon Tetrachloride / Q000009:adverse effects; D002460:Cell Line; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D019610:Cytoprotection / Q000187:drug effects*; D006801:Humans; D027723:Ipomoea batatas / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012449:Safety
D000872:Anthocyanins; D000975:Antioxidants; D015415:Biomarkers; D017382:Reactive Oxygen Species; D002251:Carbon Tetrachloride