Anti-tumour and immunomodulatory activities of oligosaccharides isolated from Panax ginseng C.A. Meyer.
Water-soluble ginseng oligosaccharides (WGOS) composed of D-glucose with a degree of polymerisation ranging from 2 to 14 were obtained from Panax ginseng C.A. Meyer. In this study, the anti-tumour and immunoregulatory effects of WGOS were evaluated in Hepatoma-22 (H22)-bearing mice. Treatment with WGOS inhibited tumour growth in vivo and significantly increased relative spleen and thymus weight, serum tumour necrosis factor-α level, spleen lymphocyte proliferation, natural killer cell activity, phagocytic function and nitric oxide production secreted by macrophage in H22-bearing mice. However, no direct cytotoxicity was detected. Therefore, the anti-tumour activity of WGOS may be related to their immunomodulatory effects.
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Lili
L
Jiao
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Xiaoyu
X
Zhang
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Bo
B
Li
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Zhen
Z
Liu
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China.
Mingzhu
M
Wang
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130117, China; Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: syliu@ciac.jl.cn.
Shuying
S
Liu
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D008262:Macrophage Activation / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005894:Panax / Q000737:chemistry*; D012995:Solubility; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014867:Water / Q000737:chemistry
D000970:Antineoplastic Agents; D007155:Immunologic Factors; D009844:Oligosaccharides; D014409:Tumor Necrosis Factor-alpha; D014867:Water
Anti-tumour; Immunomodulatory; Oligosaccharides; Panax ginseng