Decomposition of L-valine under nonthermal dielectric barrier discharge plasma.
L-Valine solutions in water and phosphate buffer were treated with nonthermal plasma generated by using a dielectric barrier discharge (DBD) device and the products generated after plasma treatments were characterized by (1)H NMR and GC-MS. Our results demonstrate that L-valine is decomposed to acetone, formic acid, acetic acid, threo-methylaspartic acid, erythro-methlyaspartic acid, and pyruvic acid after direct exposure to DBD plasma. The concentrations of these compounds are time-dependent with plasma treatment. The mechanisms of L-valine under the DBD plasma are also proposed in this study. Acetone, pyruvic acid, and organic radicals (•)CHO, CH3COCH2OO(•) (acetonylperoxy), and CH3COC(OH)2OO(•) (1,1-dihydroxypropan-2-one peroxy) may be the determining chemicals in DNA damage.
Department of Chemistry, Drexel University , Philadelphia, Pennsylvania 19104, United States.
Yingying
Y
Li
Arben
A
Kojtari
Gary
G
Friedman
Ari D
AD
Brooks
Alex
A
Fridman
Hai-Feng
HF
Ji
D000388:Air; D004249:DNA Damage; D017666:Deuterium Oxide / Q000737:chemistry; D017097:Electric Impedance; D007700:Kinetics; D010100:Oxygen / Q000737:chemistry; D058626:Plasma Gases / Q000737:chemistry*; D014633:Valine / Q000737:chemistry* / Q000494:pharmacology
D058626:Plasma Gases; D014633:Valine; D017666:Deuterium Oxide; D010100:Oxygen