The prostate cancer risk stratification project: database construction and risk stratification outcome analysis.
This investigation reports on the biochemical and clinical outcomes of a newly created pan-Canadian Prostate Cancer Risk Stratification (ProCaRS) database developed by the Genitourinary Radiation Oncologists of Canada (GUROC). GUROC ProCaRS template-compliant data on 7974 patients who underwent radiotherapy were received from 7 unique databases. Descriptive analysis, Cox proportional hazards, and Kaplan-Meier analyses were performed using American Society for Radiation Oncology (ASTRO) biochemical failure-free survival (BFFS), prostate cancer-specific survival, and overall survival. Multivariable modeling for the primary ASTRO BFFS end point showed that age, prostate-specific antigen, T stage, and Gleason score and components such as hormonal therapy, and radiation treatment (brachytherapy with better outcome than external-beam) were predictive of outcome. Kaplan-Meier analysis of the existing GUROC and new NCCN classification system both showed good separation of all clinical outcome curves. The construction of a pan-Canadian database has informed important prostate cancer radiotherapy outcomes and risk stratification.
From the aDepartment of Radiation Oncology, London Health Sciences Centre, London, Ontario; bDepartment of Radiation Oncology, Juravinski Cancer Centre, Hamilton, Ontario; cRadiation Medicine Program, Princess Margaret Cancer Centre, Toronto, Ontario; dDepartment of Radiation Oncology, Kingston Regional Cancer Centre, Kingston, Ontario; eDepartment of Radiation Oncology, Montreal General Hospital, Montreal, Quebec; fDepartment of Radiation Oncology, Kelowna General Hospital, Kelowna, British Columbia; gDepartment of Radiation Oncology, L'Hotel Dieu de Quebec, Quebec City, Quebec; hDepartment of Radiation Oncology, British Columbia Cancer Agency - Vancouver Centre, Vancouver, British Columbia, Canada.
George
G
Rodrigues
Himu
H
Lukka
Padraig
P
Warde
Michael
M
Brundage
Luis
L
Souhami
Juanita
J
Crook
Fabio
F
Cury
Charles
C
Catton
Gary
G
Mok
Andre-Guy
AG
Martin
Eric
E
Vigneault
Jim
J
Morris
Andrew
A
Warner
Sandra Gonzalez
SG
Maldonado
Tom
T
Pickles
D000368:Aged; D001918:Brachytherapy; D002170:Canada; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012306:Risk; D018570:Risk Assessment; D016896:Treatment Outcome
D017430:Prostate-Specific Antigen