Synthesis, characterization and biological studies of substituted quinozoline-4-(3H)-ones containing diazepine moiety.
The synthesis and characterization of new series of 1,4-benzodiazepine derivatives have been presented. The structures were confirmed by elemental analyses, IR spectral, (1)H NMR spectral and mass spectral data. All the compounds were screened for in vitro antimicrobial and anthelmintic activities. The antibacterial activity was tested against Staphylococcus aureus (Gram positive), Bacillus cereus (Gram positive), Escherichia coli (Gram negative) and Pseudomonas aeruginosa (Gram negative). The antifungal activity was tested against Aspergillus niger and Candida albicans. All the compounds showed considerable antimicrobial activity against the microorganism studied. The significant anthelmintic activity of all novel compounds was demonstrated against Pheretima posthuma. Based on the nature of substituent present, the structure-activity correlation of novel compounds was discussed.
Department of Chemistry, Sri Krishnadevaraya University, Anantapur, AP, India.
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Narayana Rao
Faculty of Science and Technology, ICFAI Foundation for Higher Education, Hyderabad, AP, India. Electronic address: guruprasadar@yahoo.co.in.
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Raghavendra Guru Prasad
Department of Chemistry, Sri Krishnadevaraya University, Anantapur, AP, India.
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Spoorthy
Department of Anatomy, Osmania Medical College, Dr. N.T.R. University of Health Sciences, Hyderabad, AP, India.
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Pariplavi
Department of Chemistry, Sri Krishnadevaraya University, Anantapur, AP, India.
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Ravindranath
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001234:Aspergillus niger / Q000187:drug effects; D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009835:Oligochaeta / Q000187:drug effects; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D001570:Benzodiazepinones; D011799:Quinazolines
1,4-benzodiazepine; Activité anthelmintique; Activité antimicrobienne; Anthelmintic activity; Antimicrobial activity; Caractérisation structurale; Structural characterization