Clinical evaluation of vancomycin dosage in pediatric oncology patients.
Vancomycin trough serum concentrations were below therapeutic range (8-15 mg/L) in 58% of 124 pediatric oncology patients receiving 60 mg/kg/d divided qid. Patients <6 and between 6 and 12 years had significantly lower trough concentrations than patients >12 years. A vancomycin dosage of 60 mg/kg/d is inadequate for pediatric oncology patients >12 years.
From the *Department of Clinical Pharmacy; †Department of Pediatric Infectious Diseases; and ‡Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
Stefan J W J
SJ
Sanders
Yuma A
YA
Bijleveld
Fleur
F
Sinkeler
Elles M
EM
Kemper
Dasja
D
Pajkrt
Marianne
M
van de Wetering
Natasha K A
NK
van Eijkelenburg
Ron A A
RA
Mathôt
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000150:complications; D012189:Retrospective Studies; D044967:Serum / Q000737:chemistry; D014640:Vancomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D014640:Vancomycin