Mechanisms and management of hypertension in autosomal dominant polycystic kidney disease.
Autosomal dominant polycystic kidney disease (ADPKD) is the most commonly inherited kidney disease, characterized by progressive cyst growth and renal enlargement, resulting in renal failure. Hypertension is common and occurs early, prior to loss of kidney function. Whether hypertension in ADPKD is a primary vasculopathy secondary to mutations in the polycystin genes or secondary to activation of the renin-angiotensin-aldosterone system by cyst expansion and intrarenal ischemia is unclear. Dysregulation of the primary cilium causing endothelial and vascular smooth muscle cell dysfunction is a component of ADPKD. In this article, we review the epidemiology, pathophysiology and clinical characteristics of hypertension in ADPKD and give specific recommendations for its treatment.
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Frederic
F
Rahbari-Oskoui
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Olubunmi
O
Williams
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Arlene
A
Chapman
D001794:Blood Pressure / Q000502:physiology*; D019468:Disease Management; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications* / Q000503:physiopathology; D012084:Renin-Angiotensin System / Q000502:physiology*
autosomal dominant polycystic kidney disease; endothelial dysfunction; hypertension; renin–angiotensin–aldosterone system; treatment