Metabolic syndrome in antipsychotic naïve patients with schizophrenia: pooled analysis of data from three Indian studies.
OBJECTIVE
This study aimed to assess the prevalence of metabolic syndrome (MS) and subthreshold MS in antipsychotic naïve patients with schizophrenia by pooling the data from three different centres in India.


METHODS
One hundred thirty-seven antipsychotic naïve patients with schizophrenia were evaluated for MS using common criteria for clinical diagnosis.


RESULTS
Twenty-six patients (19%) met consensus criteria. Additionally, 56 patients (40.9%) fulfilled one criterion and 32 patients (23.3%) fulfilled two criteria of MS out of five criteria.


CONCLUSIONS
One-fifth of antipsychotic naïve patients with schizophrenia had MS and another two-third had at least one metabolic abnormality. Awareness of such a high risk is vitally important for rational selection of antipsychotic medications as well as effective implementation of preventive measures.
Postgraduate Institute of Medical Education and Research, Chandigarh.
Sandeep
S
Grover
All India Institute of Medical Sciences, Jodhpur.
Naresh
N
Nebhinani
Schizophrenia Research Foundation (India), Chennai.
Ramachandran
R
Padmavati
All India Institute of Medical Sciences, New Delhi, India.
Rakesh K
RK
Chadda
Hunter New England Area Health Service, The University of Newcastle, Newcastle, NSW, Australia.
Srinivasan
S
Tirupati
All India Institute of Medical Sciences, New Delhi, India.
Abhishek
A
Pallava
D000293:Adolescent; D000328:Adult; D000368:Aged; D015897:Comorbidity; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology*; D044465:White People / Q000523:psychology / Q000706:statistics & numerical data*; D055815:Young Adult
drug naïve; metabolic syndrome; schizophrenia