Black tea supplementation improves antioxidant status in rats subjected to oxidative stress.
The protective effect of black tea extract (BTE) against HgCl2-induced oxidative damage in Wistar rats was investigated. Rats were injected with HgCl2 (5 mg/kg body weight in 0.9% NaCl) to induce oxidative stress. The aqueous BTE (2.5%) was prepared from CTC (curl, tear, crush) grade tea. BTE was fed to control and HgCl2-treated rats by gavage at a dose of 1 ml/(100 g body weight d). Biomarkers of oxidative stress, such as the erythrocyte plasma membrane redox system (PMRS) activity, lipid peroxidation, and advanced oxidation protein products (AOPP), increased by 166, 31, and 373%, respectively, in response to HgCl2 treatment, while intracellular glutathione and plasma antioxidant potential, i.e. ferric reducing ability (FRAP) decreased by 75 and 22%, respectively. BTE protected the rats against HgCl2-induced oxidative damage and raised the antioxidant potential in control rats. Due to its strong antioxidant effect in vivo, black tea intake may provide a significant health-promoting effect to humans.
Department of Biochemistry, University of Allahabad, Allahabad, U. P. 211002, India.
Dileep
D
Kumar
Department of Biochemistry, University of Allahabad, Allahabad, U. P. 211002, India.
Syed Ibrahim
SI
Rizvi
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013662:Tea
D000975:Antioxidants; D013662:Tea; D008315:Malondialdehyde; D005978:Glutathione