Eculizumab therapy in a patient with dense-deposit disease associated with partial lipodystropy.
BACKGROUND
Dense deposit disease (DDD) (also known as membranoproliferative glomerulonephritis type II) in childhood is a rare glomerulonephritis with frequent progression to end-stage renal disease (ESRD) and a high recurrence after kidney transplantation. The pathophysiologic basis of DDD is associated with the uncontrolled systemic activation of the alternative pathway (AP) of the complement cascade.


METHODS
A 14-year-old girl presented with edema and nephrotic range proteinuria. Blood tests showed hypoalbuminemia, nephrotic range proteinuria, normal renal function, and a low C3 level. Renal biopsy confirmed the diagnosis of crescentic DDD. Complement analysis revealed strong AP activation (low C3), positive C3 nephritic factor (C3NeF), and a decreased complement factor H (CFH) levels with CFH polymorphisms. Therapy with eculizumab was considered after the failure of corticosteroid and plasmapheresis to modulate the ongoing massive proteinuria and persistence of low serum C3 levels. There was a marked clinical and biochemical response following the administration of eculizumab.


CONCLUSIONS
Our case emphasizes the efficacy of eculizumab in the management of crescentic DDD in a patient with a normal renal function, in a short follow-up period. Considering previously reported cases, it appears that eculizumab represents a promising new approach which may prevent progression to ESRD in a subset of patients with DDD.
Pediatric Nephrology Department, Ondokuz Mayis University Faculty of Medicine, Kurupelit, Samsun, Turkey.
Ozan
O
Ozkaya
Hulya
H
Nalcacioglu
Demet
D
Tekcan
Gurkan
G
Genc
Bilge Can
BC
Meydan
B Handan
BH
Ozdemir
M Kemal
MK
Baysal
Hasan Tahsin
HT
Keceligil
D000293:Adolescent; D061067:Antibodies, Monoclonal, Humanized / Q000627:therapeutic use*; D003176:Complement C3 / Q000032:analysis; D003178:Complement C3 Nephritic Factor / Q000172:deficiency; D017242:Complement Factor H / Q000172:deficiency; D003170:Complement Pathway, Alternative; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008060:Lipodystrophy / Q000150:complications*
D061067:Antibodies, Monoclonal, Humanized; D003176:Complement C3; D003178:Complement C3 Nephritic Factor; D017242:Complement Factor H; C481642:eculizumab