Diffuse large B-cell lymphoma, not otherwise specified of the palate: A case report.
Diffuse large B-cell lymphoma (DLBCL) is the most frequent type of non-Hodgkin´s lymphoma found in oral and maxillofacial regions. A large number of cases may be biologically heterogeneous, which are commonly defined as DLBCL, not otherwise specified (NOS) by the World Health Organization (WHO-2008). The present case reports on an ulcer of raised and irregular edges, found on the border between the hard and soft palate, as the first and only manifestation of an extranodal non-Hodgkin lymphoma in an 85-year-old patient. Incisional biopsy was carried out, and the specimen revealed a proliferation of large lymphoid cells suggestive of diffuse large cell lymphoma. An immunohistochemical analysis was performed. EBV-RNA was assessed by in situ hybridization that also proved to be negative. Immunohistochemical and EBV analyses are important to avoid delays and inappropriate treatment strategies. Although advanced age is considered an adverse prognostic factor, early diagnosis did prove to be a key contributory factor in the cure of non-Hodgkin lymphoma. Key words:Diffuse large B-cell lymphoma, elderly, EBV.
DDS. MSc. Department of Oral Surgery and Pathology.School of Dentistry. Universidade Federal de Minas Gerais.
Giovanna R
GR
Souto
DDS. Department of Oral Surgery and Pathology.School of Dentistry. Universidade Federal de Minas Gerais.
Thaís Sf
TS
Pereira
MD. Oncomed. Belo Horizonte. Minas Gerais, Brazil ; MD. Hospital Felício Rocho. Belo Horizonte. Minas Gerais, Brazil.
Alexandre F
AF
Castro
DDS. PhD. Department of Oral Surgery and Pathology.School of Dentistry. Universidade Federal de Minas Gerais.
Ricardo A
RA
Mesquita