[Genetic and cytogenetic predictors of human chromosomal radiosensitivity].
We studied association between the frequencies of gamma-induced (1 Gy in vitro) chromosome aberrations in blood lymphocytes and polymorphism of 45 repair candidate genes, detoxification and oxidative stress genes (53 sites) for 99 healthy volunteers. The levels of chromosome-type aberrations correlated with carriage of the minor alleles of the genes OGG1 Ser326Cys, ABCB1 Ile1145 = and NQO1 Pro187Ser (p = 0.0002). We have shown that all the revealed genetic associations were less effective in predicting chromosomal radiosensitivity as compared to the correlations between spontaneous and gamma-induced aberrations (p = 1.0 x 10(-6)). The addition of genetic markers to cytogenetic predictors improved the predictive accuracy for chromosomal radiosensitivity with the multiple correlation coefficient reaching R = 0.58 (p = 3.1 x 10(-8)). Thereby we were able to explain more than 30% of the population variability in chromosomal radiosensitivity.
L E
LE
Sal'nikova
A G
AG
Chumachenko
O B
OB
Belopol'skaia
A V
AV
Rubanovich
D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics; D002869:Chromosome Aberrations / Q000528:radiation effects*; D045647:DNA Glycosylases / Q000235:genetics; D005720:Gamma Rays; D056726:Genetic Association Studies; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D018384:Oxidative Stress / Q000235:genetics*; D011110:Polymorphism, Genetic; D011836:Radiation Tolerance / Q000235:genetics*; D014838:Volunteers
C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human