[Importance of NAMPT-mediated NAD-biosynthesis and NAD-dependent deacetylase SIRT1 in the crosstalk between circadian rhythm and metabolism].
Circadian rhythms are generated by well-conserved interlocked transcriptional feedback loops that involve clock genes. A growing body of research suggests that there is biological crosstalk between circadian rhythm and metabolism. We recently found that the key NAD biosynthetic enzyme, nicotinamide phosphoribosyltransferase (NAMPT), and NAD-dependent deacetylase SIRT1 play a critical role in such crosstalk, by creating a novel feedback loop in which NAD functions as a "metabolic oscillator". This review aims to summarize recent progress in elucidating the pathophysiological importance of clock genes, NAMPT-mediated NAD biosynthesis, and SIRT1, in the crosstalk between circadian rhythm and metabolism.
Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, USA.
Jun
J
Yoshino
D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism; D025461:Feedback, Physiological / Q000502:physiology; D006801:Humans; D009243:NAD / Q000378:metabolism*; D054409:Nicotinamide Phosphoribosyltransferase / Q000378:metabolism*; D056564:Sirtuin 1 / Q000378:metabolism*
D016207:Cytokines; D009243:NAD; D054409:Nicotinamide Phosphoribosyltransferase; C447939:SIRT1 protein, human; D056564:Sirtuin 1