Highly effective antibiofilm coating of silver-polymer nanocomposite on polymeric medical devices deposited by one step plasma process.
Foley's catheters were coated with Silver (Ag), plasma polymerized aniline (PPAni) and Ag-PPAni composite by plasma based deposition processes which were characterized by XRD, EDX, SEM, and FT-IR spectroscopy and bioassays were performed to validate their efficacies to kill planktonic cells as well as to remove biofilm. The analyses confirmed the formation of Ag nanoparticles (AgNPs), PPAni and Ag-PPAni composite and also corroborated their successful deposition over the catheters. Antibacterial assays showed that coated catheters were capable of killing planktonic cells of most commonly encountered uropathogens and equally capable of eradicating biofilm formation by the uropathogens as evident from the reduced cfu/ml. UV-vis spectroscopy results showed that the nanoparticle coated catheters were capable of gradual release of AgNPs, killing all planktonic cells in solution over the time. Foley's catheters coated with AgNPs and their composites by one step plasma process were non-toxic devices capable of killing planktonic cells and proficient in eradicating biofilm formation which could be used to cutback the likelihood of the catheter related complications.
Physical Sciences Division Institute of Advanced Study in Science and Technology, Paschim Boragaon, Garchuk, Guwahati, 781035, Assam, India; Centre for Studies in Biotechnology, Dibrugarh University, Dibrugarh, 786004, Assam, India.
Munin
M
Agarwala
Tapan
T
Barman
Dolly
D
Gogoi
Bula
B
Choudhury
Arup R
AR
Pal
R N S
RN
Yadav
D000814:Aniline Compounds / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000502:physiology*; D053761:Nanocomposites / Q000737:chemistry*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology
D000814:Aniline Compounds; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; C416807:polyaniline; D012834:Silver
Foley's catheter; MRSA; biofilm; plasma deposition; silver nanoparticle