[Genome-wide identification of functional noncoding RNAs,].
Non-coding RNAs (ncRNAs) are functional transcripts that do not encode proteins. They are involved in many regulation pathways. The only general characteristic shared by many (but not all) known RNAs is folding into complex shapes that are crucial to function and thus should be conserved. This fact can be used for genome-wide prediction of ncRNAs. Our approach is based on computing of local base pairing probabilities and further maximizing of probability for a segment with the use of Nussinoff algorithm. We showed that it allows to efficiently predict known ncRNA and possibly some new ncRNAs.
S V
SV
Vinogradova
R A
RA
Soldatov
A A
AA
Mironov
D000465:Algorithms; D000818:Animals; D001483:Base Sequence; D004330:Drosophila / Q000235:genetics*; D016678:Genome; D049750:Genome, Insect; D008969:Molecular Sequence Data; D012326:RNA Splicing; D022661:RNA, Untranslated / Q000032:analysis*
D022661:RNA, Untranslated