Direct access to α-trifluoromethyl enones via efficient copper-catalyzed trifluoromethylation of Meyer-Schuster rearrangement.
A novel domino copper-catalyzed trifluoromethylated Meyer-Schuster rearrangement reaction with Togni's reagent was developed, leading to α-trifluormethyl (CF3) enone products with moderate to good yields. Furthermore, α-CF3 enones can be transformed toward important trifluoromethyl heterocyclic motifs in a one-pot version.
Department of Chemistry South University of Science and Technology of China , Shenzhen, 518055, P. R. China.
Ya-Ping
YP
Xiong
Ming-Yue
MY
Wu
Xiang-Yu
XY
Zhang
Can-Liang
CL
Ma
Lin
L
Huang
Li-Jiao
LJ
Zhao
Bin
B
Tan
Xin-Yuan
XY
Liu
D000478:Alkylation; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D006571:Heterocyclic Compounds; D006845:Hydrocarbons, Fluorinated; D003300:Copper