Intraparenchymal leiomyoma of the breast: report of a case with emphasis on needle core biopsy-based diagnosis.
OBJECTIVE
We report the clinicopathologic features of a rare case of leiomyoma of the breast parenchyma in a 36-year-old female, diagnosed preoperatively at core biopsy. A complete review of the literature on the topic is provided and differential diagnostic problems are discussed.


METHODS
Standard histological examination and immunohistochemical analyses using a large panel of antibodies were performed in both the core biopsy and surgical specimen.


RESULTS
Ultrasonography revealed a well-circumscribed tumour mass without calcifications. Histological examination of the core biopsy showed proliferation of bland-looking eosinophilic spindle cells arranged in a fascicular growth pattern. Mitoses, pleomorphism and necrosis were absent. Immunohistochemistry, revealing diffuse staining for a-smooth muscle actin, desmin and h-caldesmon, confirmed the leiomiomatous nature of neoplastic cells. Histological and immunohistochemical analyses of the surgical specimen confirmed the definitive diagnosis of leiomyoma.


CONCLUSIONS
The present case emphasizes that diagnosis of leiomyoma of the breast parenchyma can be confidentially rendered on needle core biopsy. We believe that correct diagnosis is primarily dependent on the awareness that this tumour can arise in this unusual site on rare occasions.
Dipartimento G. F. Ingrassia, Anatomia Patologica, Università di Catania, AOU Policlinico-Vittorio Emanuele, Catania.
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Vecchio
Istituto di Anatomia Patologica, Azienda Ospedaliera di Perugia, Perugia.
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Cavaliere
Anatomia Patologica, Ospedale Città di Castello, Città di Castello.
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Cartaginese
Anatomia Patologica, Ospedale Città di Castello, Città di Castello.
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Lucaccioni
U. O. di Senologia, Ospedale Città di Castello, Città di Castello.
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Lombardi
Dipartimento Scienze Biomediche, Sezione di Fisiologia, Università di Catania, Catania.
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Parenti
Dipartimento G. F. Ingrassia, Anatomia Patologica, Università di Catania, AOU Policlinico-Vittorio Emanuele, Catania.
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Salvatorelli
Dipartimento G. F. Ingrassia, Anatomia Patologica, Università di Catania, AOU Policlinico-Vittorio Emanuele, Catania.
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Magro
D000328:Adult; D044963:Biopsy, Fine-Needle; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000175:diagnosis / Q000473:pathology*