Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme.
BACKGROUND
We present the final results of the effect of lung cancer screening with low-dose CT on the smoking habits of participants in a 5-year screening trial.


METHODS
The Danish Lung Cancer Screening Trial (DLCST) was a 5-year screening trial that enrolled 4104 subjects; 2052 were randomised to annual low-dose CT (CT group) and 2052 received no intervention (control group). Participants were current and ex-smokers (≥4 weeks abstinence from smoking) with a tobacco consumption of ≥20 pack years. Smoking habits were determined annually. Missing values for smoking status at the final screening round were handled using two different models.


RESULTS
There were no statistically significant differences in annual smoking status between the CT group and control group. Overall the ex-smoker rates (CT + control group) significantly increased from 24% (baseline) to 37% at year 5 of screening (p<0.001). The annual point prevalence quit rate increased from 11% to 24% during the five screening rounds; the ex-smokers' relapse rate remained stable, around 11%, across the same period.


CONCLUSIONS
Screening with low-dose CT had no extra effect on smoking status compared with the control group, but overall the screening programme probably promoted smoking cessation.


BACKGROUND
The DLCST is registered in Clinical Trials.gov Protocol Registration System (identification no. NCT00496977).
Department of Respiratory Medicine, Gentofte University Hospital, Hellerup, Denmark Department of Radiology, Akershus University Hospital, Lørenskog, Norway.
Haseem
H
Ashraf
Department of Respiratory Medicine, Gentofte University Hospital, Hellerup, Denmark.
Zaigham
Z
Saghir
Department of Respiratory Medicine, Gentofte University Hospital, Hellerup, Denmark.
Asger
A
Dirksen
Department of Thoracic Surgery RT, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Jesper Holst
JH
Pedersen
Department of Respiratory Medicine, Gentofte University Hospital, Hellerup, Denmark.
Laura Hohwü
LH
Thomsen
Department of Internal Medicine, Frederikssund Hospital, Frederikssund, Denmark.
Martin
M
Døssing
Department of Respiratory Medicine, Gentofte University Hospital, Hellerup, Denmark.
Philip
P
Tønnesen
D000368:Aged; D003718:Denmark / Q000453:epidemiology; D055088:Early Detection of Cancer / Q000379:methods* / Q000523:psychology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009042:Motivation; D015995:Prevalence; D011829:Radiation Dosage; D012907:Smoking / Q000453:epidemiology* / Q000523:psychology; D016540:Smoking Cessation / Q000523:psychology / Q000706:statistics & numerical data*; D014057:Tomography, X-Ray Computed
Lung Cancer; Tobacco and the lung