[Neurobehavioral derangement in medaka fish receiving polybrominated diphenyl ethers (PBDE-47) during the early-stage development].
OBJECTIVE
To investigate the neurobehavioral toxicity of polybrominated diphenyl ethers(PBDE-47) to larval medaka during the early-stage development.


METHODS
Early-life stage fish were treated with PBDE-47, control, and solvent control. Animals were randomly collected on 5, 10 and 60 days after exposure, and some toxicological endpoints such as startle response, optokinetic response (OKR), optomotor response (OMR) and dorsal light response (DLR) were measured.


RESULTS
There were no any significant difference in body weight gain or body length in the PBDE-47 treated medaka except for the highest concentration. Both startle response and escape response were inhibited in dose-related manners. Furthermore, delayed OMR and DLR were induced in the higher PBDE-47 groups (P < 0.05 or P < 0.01). However, OKR was similar between the each group.


CONCLUSIONS
Harmony of the sense-behavior in the medaka larvae could be impaired by PBDEs, and further study should focus on the relationship between the toxicity and hormone disruption caused by PBDE-47.
Department of Public Health, Anhui Medical University, Hefei 230601, China. uyuan@mail.ustc.edu.cn
Yuan
Y
Wu
Department of Public Health, Anhui Medical University, Hefei 230601, China.
Tianli
T
Zheng
Department of Public Health, Anhui Medical University, Hefei 230601, China.
Jingya
J
Wang
Department of Public Health, Anhui Medical University, Hefei 230601, China.
Yali
Y
Zhang
Department of Public Health, Anhui Medical University, Hefei 230601, China.
Tingting
T
Chen
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D005411:Flame Retardants / Q000633:toxicity; D055768:Halogenated Diphenyl Ethers / Q000633:toxicity*; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D009990:Oryzias / Q000235:genetics / Q000254:growth & development*
D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers