Deficiency of 25-hydroxyvitamin d and dyslipidemia in Indian subjects.
Background. Vitamin D deficiency is widespread throughout the world. Several reports have incriminated vitamin D deficiency as the cause of rickets, osteomalacia, and other chronic diseases. Recent studies have suggested a possible link between deficiency of 25-hydroxyvitamin D and dyslipidemia. Aim. To investigate the association between 25-hydroxyvitamin D deficiency and dyslipidemia in Indian subjects. Methodology. We recruited 150 asymptomatic consecutive subjects from patients' attendees at the Departments of Neurology and Medicine in Yashoda Hospital, Hyderabad, India. Study period was from October 2011 to March 2012. All subjects underwent 25-hydroxyvitamin D assay by chemiluminescent microparticle immunoassay, fasting blood sugar and lipid profile, calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP). Results. Out of 150 subjects, men were 82 (54.6%), and mean age was 49.4 (±15.6) years. Among risk factors, hypertension was noted in 63/150 (42%), 25-hydroxyvitamin D deficiency in 59/150 (39.3%), diabetes in 45/150 (30%), dyslipidemia in 60 (40%), smoking in 35/150 (23.3%), and alcoholism in 27/150 (18%). Deficiency of 25-hydroxyvitamin D was significantly associated with dyslipidemia (P = 0.0001), mean serum glucose (P = 0.0002) mean CRP (P = 0.04), and mean alkaline phosphatase (P = 0.01). Multivariate analysis showed that 25-hydroxyvitamin D deficiency was independently associated with dyslipidemia (odds ratio: 1.9; 95% CI : 1.1-3.5). Conclusions. We found that deficiency of 25-hydroxyvitamin D was independently associated with dyslipidemia in Indian subjects.
Department of Neurology, Yashoda Hospital, Hyderabad, India.
Jaydip Ray
JR
Chaudhuri
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India.
K Rukmini
KR
Mridula
Department of Biochemistry, Yashoda Hospital, Hyderabad, India.
Alluri
A
Anamika
Department of Neurology, Caringhands Neurocenter, Vizag, India.
Demudu Babu
DB
Boddu
Department of Medicine, Yashoda Hospital, Hyderabad, India.
Pradeep Kumar
PK
Misra
Director of Medical Services, Yashoda Hospital, Hyderabad, India.
A
A
Lingaiah
Department of Medicine, Yashoda Hospital, Hyderabad, India.
Banda
B
Balaraju
Department of Neurology, Yashoda Hospital, Hyderabad, India ; Department of Clinical Research, Yashoda Hospital, Hyderabad 500082, India.
Vcs Srinivasarao
VS
Bandaru