Is the Campylobacter jejuni secretory protein Cj0069 a suitable antigen for serodiagnostics?
Campylobacter spp. is the most common bacterial pathogen of gastroenteritis worldwide. Poultry is the main reservoir and consequently the main origin of infections for humans. As a consequence of a primary Campylobacter infection which typically manifests as diarrhea, there is an increased risk to suffer from post-infectious complications such as reactive arthritis, neuropathia, myositis or a Guillain-Barré Syndrome. Usually the verification of acute campylobacteriosis is made by stool culture. In contrast, post-infectious complications can be diagnosed by serological assays. Since most of them are based on whole cell lysates, an insufficient specificity results from cross-reactions between related species. Therefore, the use of recombinant antigens becomes more and more favorable. Campylobacter is able to secrete a number of proteins, which are amongst others necessary for cell invasion and therefore play a crucial role for virulence. One of these, Cj0069, has a similar specificity and sensitivity in the detection of anti-Campylobacter jejuni IgG compared to the well-established antigens OMP18 and P39. This makes it a suitable antigen for diagnosing C. jejuni post-infectious complications.
Abteilung für Medizinische Mikrobiologie, Universitätsmedizin Göttingen Kreuzbergring 57, D-37075 Göttingen Germany.
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Corso
Abteilung für Medizinische Mikrobiologie, Universitätsmedizin Göttingen Kreuzbergring 57, D-37075 Göttingen Germany.
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Lugert
Abteilung für Medizinische Mikrobiologie, Universitätsmedizin Göttingen Kreuzbergring 57, D-37075 Göttingen Germany.
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Groß
Abteilung für Medizinische Mikrobiologie, Universitätsmedizin Göttingen Kreuzbergring 57, D-37075 Göttingen Germany.
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Zautner
Campylobacter jejuni; Cj0069; Guillain-Barré syndrome; OMP18; P39; arthritis; campylobacteriosis; serodiagnostics