Static magnetic field effects on impaired peripheral vasomotion in conscious rats.
We investigated the SMF effects on hemodynamics in the caudal artery-ligated rat as an in vivo ischemia model using noninvasive near-infrared spectroscopy (NIRS) combined with power spectral analysis by fast Fourier transform. Male Wistar rats in the growth stage (10 weeks old) were randomly assigned into four groups: (i) intact and nonoperated cage control (n = 20); (ii) ligated alone (n = 20); (iii) ligated and implanted with a nonmagnetized rod (sham magnet; n = 22); and (vi) ligated and implanted with a magnetized rod (n = 22). After caudal artery ligation, a magnetized or unmagnetized rod (maximum magnetic flux density of 160 mT) was implanted transcortically into the middle diaphysis of the fifth caudal vertebra. During the experimental period of 7 weeks, NIRS measurements were performed in 3- , 5- , and 7-week sessions and the vasomotion amplitude and frequency were analyzed by fast Fourier transform. Exposure for 3-7 weeks to the SMF significantly contracted the increased vasomotion amplitude in the ischemic area. These results suggest that SMF may have a regulatory effect on rhythmic vasomotion in the ischemic area by smoothing the vasomotion amplitude in the early stage of the wound healing process.
Department of Mechanical Engineering and Science, Graduate School of Engineering, Kyoto University, Kyoto 606-8502, Japan ; Research Section for Magnetics, Product Development Department, Development Division, PIP Company, Osaka 540-0011, Japan.
Shenzhi
S
Xu
Research Section for Magnetics, Product Development Department, Development Division, PIP Company, Osaka 540-0011, Japan ; Research Center for Frontier Medical Engineering, Chiba University, Chiba 263-8522, Japan.
Hideyuki
H
Okano
Department of Physical Therapy, School of Health Science and Social Welfare, Kibi International University, Okayama 716-8508, Japan.
Masaaki
M
Nakajima
Department of Mechanical Engineering and Science, Graduate School of Engineering, Kyoto University, Kyoto 606-8502, Japan.
Naoya
N
Hatano
Department of Mechanical Engineering and Science, Graduate School of Engineering, Kyoto University, Kyoto 606-8502, Japan.
Naohide
N
Tomita
Department of Medical Engineering, Nara Medical University, Nara 634-8522, Japan.
Yoshito
Y
Ikada