Clobazam-clonazepam combination effective for stimulus-induced falling in hyperekplexia.
A child with the major form of hyperekplexia is presented who stopped ambulating because of frequent unexpected falls associated with acoustic and visual stimuli. A combination of clobazam and clonazepam was well tolerated and was rapidly and dramatically effective in eliminating the falls and restoring ambulation.
Division of Child Neurology, Meadowlands Hospital Medical Center, Seton Hall School of Health & Medical Sciences, Secaucus, NJ, USA gmcabee@meadowlandsphysicians.org.
Gary N
GN
McAbee
D000058:Accidental Falls / Q000517:prevention & control*; D000927:Anticonvulsants / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D002648:Child; D000078306:Clobazam; D002998:Clonazepam / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D016750:Stiff-Person Syndrome / Q000150:complications* / Q000188:drug therapy*
D000927:Anticonvulsants; D001569:Benzodiazepines; D000078306:Clobazam; D002998:Clonazepam
clobazam; clonazepam; falling; hyperekplexia