MicroRNA-106a targets TIMP2 to regulate invasion and metastasis of gastric cancer.
Emerging evidence has shown that microRNA plays an important role in tumor development and progression. Here, we report that miR-106a is frequently up-regulated in gastric cancer tissues and positively correlates with metastasis. Restrained expression of miR-106a in gastric cancer cells significantly reduces their capacity of proliferation, migration and invasion. In tissue sections, the positive signal of miR-106a localized in metastasis-associated regions confirmed this result. Moreover, we show that TIMP2 is a direct downstream target for miR-106a and knockdown of TIMP2 strengthens the beneficial effects of miR-106a. Our study adds miR-106a to the complex mechanisms of tumor metastasis.
Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Rood, Xi'an, Shanxi 710061, People's Republic of China.
Meng
M
Zhu
Department of Pathology, General Hospital of Ningxia Medical University, Yinchuan, People's Republic of China.
Ning
N
Zhang
Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Rood, Xi'an, Shanxi 710061, People's Republic of China. Electronic address: hesx123@126.com.
Shuixiang
S
He
Department of Gastroenterology, The Central Hospital of Xi'an, Xi'an, People's Republic of China.
Yuanyuan
Y
Lui
Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Rood, Xi'an, Shanxi 710061, People's Republic of China.
Guifang
G
Lu
Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, 277 West Yanta Rood, Xi'an, Shanxi 710061, People's Republic of China.
Lin
L
Zhao
D001483:Base Sequence; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D005260:Female; D005557:Formaldehyde / Q000378:metabolism; D055785:Gene Knockdown Techniques; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D016612:Paraffin Embedding; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*; D016707:Tissue Fixation; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000172:deficiency / Q000235:genetics*; D015854:Up-Regulation / Q000235:genetics
C542541:MIRN106 microRNA, human; D035683:MicroRNAs; C560823:TIMP2 protein, human; D019716:Tissue Inhibitor of Metalloproteinase-2; D005557:Formaldehyde
Gastric cancer; Matrix metalloproteinase 2; Metastasis; MicroRNA-106a; Tissue inhibitor of metalloproteinase 2