Levels of dechloranes and polybrominated diphenyl ethers (PBDEs) in human serum from France.
Human exposure to dechloranes has been evaluated in Western Europe (France) with the analysis of Dechlorane Plus (DP), Dechloranes (Dec) 602, 603 and 604, Chlordene Plus (CP) and Mirex in 48 serum samples collected between 2003 and 2005. While no production source has been identified in Europe until now, detection frequencies for all investigated dechloranes were high, except for Dec 604 which was below detection limit for all samples. The mean DP concentration was 1.40±1.40ng/g lipid weight (lw), lower than levels reported in serum from Chinese population, but higher than levels reported in Canadian human milk. To the best of our knowledge, this is the first time that ∑5dechlorane levels are reported for human serum. A specific pattern of contamination was found (Dec 603>DP>Mirex>Dec 602>CP) compared to other biota samples that have been analyzed from Europe, with Dec 603 as the most abundant dechlorane (mean level: 2.61±2.63ng/g lw). Dec 603 and CP levels were correlated with age and with levels of some bioaccumulative organochlorine pesticides (OCPs). These results indicate that bioaccumulation properties should be further investigated and taken in consideration when assessing human exposure to dechloranes. For comparison purposes, polybrominated diphenyl ether (PBDE) levels were also measured for BDE-47, -99, -100, -153 and -154 in the serum samples. As expected, BDE-47 and BDE-153 were the major congeners with mean levels of 2.06±1.80ng/g lw and 1.39±0.97ng/g lw, respectively. The mean ∑5PBDE levels (4.32±2.99ng/g lw) were in the range typical of Western Europe levels, but lower than the mean ∑5dechlorane levels (6.24±4.16ng/g lw). These results indicate that the attention to dechloranes should be continued if research indicates toxicological concerns.
CART, Organic and Biological Analytical Chemistry, Chemistry Department, University of Liège, Allée du 6 août, B6c, Sart-Tilman, B-4000 Liège, Belgium; CART, Mass Spectrometry Laboratory, Chemistry Department, University of Liège, Allée du 6 août, B6c, Sart-Tilman, B-4000 Liège, Belgium.
Catherine
C
Brasseur
CART, Organic and Biological Analytical Chemistry, Chemistry Department, University of Liège, Allée du 6 août, B6c, Sart-Tilman, B-4000 Liège, Belgium.
Catherine
C
Pirard
CART, Mass Spectrometry Laboratory, Chemistry Department, University of Liège, Allée du 6 août, B6c, Sart-Tilman, B-4000 Liège, Belgium.
Georges
G
Scholl
CART, Mass Spectrometry Laboratory, Chemistry Department, University of Liège, Allée du 6 août, B6c, Sart-Tilman, B-4000 Liège, Belgium.
Edwin
E
De Pauw
INSERM U1085, Epidemiological Research on Environment, Reproduction and Development, Faculty of Medicine, University of Rennes, Campus de Beaulieu, 35042 Rennes, France.
Jean-François
JF
Viel
Ontario Ministry of the Environment, 125 Resources Road, Toronto, M9P 3V6 Ontario, Canada.
Li
L
Shen
Ontario Ministry of the Environment, 125 Resources Road, Toronto, M9P 3V6 Ontario, Canada.
Eric J
EJ
Reiner
CART, Organic and Biological Analytical Chemistry, Chemistry Department, University of Liège, Allée du 6 août, B6c, Sart-Tilman, B-4000 Liège, Belgium. Electronic address: JF.Focant@ulg.ac.be.
Jean-François
JF
Focant
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005602:France; D055768:Halogenated Diphenyl Ethers / Q000097:blood*; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D008297:Male; D008875:Middle Aged
D004785:Environmental Pollutants; D055768:Halogenated Diphenyl Ethers; D006843:Hydrocarbons, Chlorinated
Blood serum; Dechloranes; Flame retardants; Human biomonitoring; PBDEs