Polymyalgia rheumatica--diagnosis and classification.
Polymyalgia rheumatica is the most common inflammatory rheumatic disease of the elderly, and shares many pathogenetic and epidemiological features with giant cell arteritis. The typical symptoms are bilateral aching of the shoulder girdle, associated with morning stiffness. The neck and hip girdle may also be involved. The diagnosis of polymyalgia rheumatica is made primarily on clinical grounds. There is no single diagnostic test, but sets of diagnostic or classification criteria have been suggested by several groups of investigators, based on the typical clinical presentation and laboratory evidence of acute-phase reaction. Other conditions that may mimic polymyalgia rheumatic, such as elderly-onset rheumatoid arthritis, must be excluded by appropriate testing and close monitoring of the disease course. Glucocorticoids at low doses (15-20 mg prednisone per day initially) are the mainstay of treatment.
Department of Internal Medicine A and the Rheumatology Service, Shaare-Zedek Medical Center, Jerusalem, Israel; The Hebrew University, Jerusalem, Israel; St. Louis University School of Medicine, St. Louis, MO, USA. Electronic address: nesher@inter.net.il.
Gideon
G
Nesher
D000210:Acute-Phase Reaction; D017668:Age of Onset; D001172:Arthritis, Rheumatoid / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D001799:Blood Sedimentation; D003937:Diagnosis, Differential; D006801:Humans; D007249:Inflammation / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology; D011111:Polymyalgia Rheumatica / Q000145:classification* / Q000175:diagnosis* / Q000453:epidemiology
Giant cell arteritis; Glucocorticoids; Morning stiffness; Sedimentation rate