The Rostro-Caudal Axis of Frontal Cortex Is Sensitive to the Domain of Stimulus Information.
Evidence suggests that lateral frontal cortex implements cognitive control processing along its rostro-caudal axis, yet other evidence supports a dorsal-ventral functional organization for processes engaged by different stimulus domains (e.g., spatial vs. nonspatial). This functional magnetic resonance imaging study investigated whether separable dorsolateral and ventrolateral rostro-caudal gradients exist in humans, while participants performed tasks requiring cognitive control at 3 levels of abstraction with language or spatial stimuli. Abstraction was manipulated by using 3 different task sets that varied in relational complexity. Relational complexity refers to the process of manipulating the relationship between task components (e.g., to associate a particular cue with a task) and drawing inferences about that relationship. Tasks using different stimulus domains engaged distinct posterior regions, but within the lateral frontal cortex, we found evidence for a single rostro-caudal gradient that was organized according to the level of abstraction and was independent of processing of the stimulus domain. However, a pattern of dorsal/ventral segregation of processing engaged by domain-specific information was evident in each separable frontal region only within the most rostral region recruited by task demands. These results suggest that increasingly abstract information is represented in the frontal cortex along distinct rostro-caudal gradients that also segregate along a dorsal-ventral axis dependent on task demands.
Department of Neurology, University of Lübeck, Lübeck, Germany Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.
Jörg
J
Bahlmann
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA Department of Neurology, University of California, Irvine, CA 92697, USA.
Robert S
RS
Blumenfeld
Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA Department of Psychology, University of California, Berkeley, CA 94720, USA.
Mark
M
D'Esposito
D001931:Brain Mapping; D003071:Cognition / Q000502:physiology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D013028:Space Perception / Q000502:physiology*; D055815:Young Adult
cognitive control; hierarchy; language; prefrontal cortex; spatial; stimulus domain