[Circadian clock disruption and diabetes mellitus].
Recent studies have demonstrated relationships between the dysfunction of circadian clocks and the development of obesity and type 2 diabetes. In humans, both shift work and the genetic variations of clock genes increase the risk of these disorders. In mice, the light conditions which induce chronic jet lag and modifications of the clock genes cause obesity and/or type 2 diabetes. Moreover, circadian clocks in peripheral tissues are impaired in both patients with type 2 diabetes and genetically obese diabetic mice. Therefore, circadian clocks are important new therapeutic targets for preventing and treating obesity and type 2 diabetes.
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University School of Medicine.
Hitoshi
H
Ando
Division of Clinical Pharmacology, Department of Pharmacology, Jichi Medical University School of Medicine.
Akio
A
Fujimura
D000818:Animals; D057906:Circadian Clocks / Q000235:genetics / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D009765:Obesity / Q000235:genetics; D020178:Sleep Disorders, Circadian Rhythm / Q000378:metabolism