Biological and demographic profile of meningiomas in a cohort of Egyptian patients: impact on tumor recurrence.
OBJECTIVE
This work was designed to study the biological and demographic characteristics of meningiomas and their impact on tumor recurrence in Egyptian patients.


METHODS
A cohort of 265 Egyptian patients with meningioma was studied. Immunohistochemistry for VEGF, Ki67, PR, CD20, and CD3 was performed. Statistical analysis was used to detect independent predictors of recurrence.


RESULTS
Adults represented 98.9% of cases, with female preponderance (M : F ratio = 1 : 2.4). Histologically, 78.10% of cases were grade I, 19.20% were grade II, and 2.60% were grade III. Transitional variant was the most common (43.40%). VEGF expression (38.50% of cases) correlated positively with perifocal edema, tumor size, and proliferative index (PI). PR expression (64.5% of cases) correlated inversely with the PI (mean 3.75). Lymphocytic aggregates were detected in 7.20% of cases, with a mean CD20 : CD3 ratio of 1 : 10.1. In a multivariate analysis, only tumor size, PR expression and necrosis predicted recurrence independently. Using ROC curve, size was the best predictor of tumor recurrence with a cut-off point of >6 cm and an excellent negative predictive value (97.6%).


CONCLUSIONS
Meningiomas in our region showed some distinctive clinicopathological and demographic criteria. Tumor size was found to be the best recurrence predictor factor of meningioma.
Department of Pathology, Faculty of Medicine, University of Alexandria, Alexandria 21533, Egypt.
Eman
E
Abdelzaher
Department of Pathology, Faculty of Medicine, University of Alexandria, Alexandria 21533, Egypt.
Nevine M F
NM
El Deeb
Department of Oncology and Nuclear Medicine, Faculty of Medicine, University of Alexandria, Alexandria 21533, Egypt.
Ahmed G
AG
Gowil
Department of Neurosurgery, Faculty of Medicine, University of Alexandria, Alexandria 21533, Egypt.
Ahmed
A
Yehya
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002648:Child; D015331:Cohort Studies; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism*; D008579:Meningioma / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism*; D012307:Risk Factors; D017678:Sex Distribution; D055815:Young Adult
D014408:Biomarkers, Tumor