A botryane metabolite with a new hexacyclic skeleton from an entomogenous fungus Hypocrea sp.
Hypocrolide A (1), a botryane metabolite with a new hexacyclic skeleton, was isolated from cultures of the entomogenous fungus Hypocrea sp. The proposed structure was confirmed by X-ray crystallography using Cu Kα radiation. The mixed-biogenetic skeleton could be derived from the hypothetical precursors related to coumarin and dihydrobotrydiol, and the latter may be derived from the coisolated 10-oxodehydrodihydrobotrydial (2) or a similar analogue.
State Key Laboratory of Mycology, Institute of Microbiology , Chinese Academy of Sciences, Beijing 100190, People's Republic of China , Beijing Institute of Pharmacology & Toxicology , Beijing 100850, People's Republic of China , and University of Chinese Academy of Sciences , Beijing 100039, People's Republic of China.
Yafei
Y
Yuan
Yu
Y
Feng
Fengxia
F
Ren
Shubin
S
Niu
Xingzhong
X
Liu
Yongsheng
Y
Che
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry; D018360:Crystallography, X-Ray; D006367:HeLa Cells; D006801:Humans; D035901:Hypocrea / Q000737:chemistry*; D061986:MCF-7 Cells; D008968:Molecular Conformation; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D003374:Coumarins; D012717:Sesquiterpenes; C588107:hypocrolide A; C030123:coumarin