Interventions for reducing benzodiazepine use in older people: meta-analysis of randomised controlled trials.
BACKGROUND
The use of benzodiazepines has been advised against in older people, but prevalence rates remain high.


OBJECTIVE
To review the evidence for interventions aimed at reducing benzodiazepine use in older people.


METHODS
We conducted a systematic review, assessment of risk of bias and meta-analyses of randomised controlled trials of benzodiazepine withdrawal and prescribing interventions.


RESULTS
Ten withdrawal and eight prescribing studies met the inclusion criteria. At post-intervention, significantly higher odds of not using benzodiazepines were found with supervised withdrawal with psychotherapy (odds ratio (OR) = 5.06, 95% CI 2.68-9.57, P<0.00001) and withdrawal with prescribing interventions (OR = 1.43, 95% CI 1.02-2.02, P = 0.04) in comparison with the control interventions treatment as usual (TAU), education placebo, withdrawal with or without drug placebo, or psychotherapy alone. Significantly higher odds of not using benzodiazepines were also found for multifaceted prescribing interventions (OR = 1.37, 95% CI 1.10-1.72, P = 0.006) in comparison with control interventions (TAU and prescribing placebo).


CONCLUSIONS
Supervised benzodiazepine withdrawal augmented with psychotherapy should be considered in older people, although pragmatic reasons may necessitate consideration of other strategies such as medication review.
Rebecca L. Gould, PhD, DClinPsy, King's College London, Department of Old Age Psychiatry, Institute of Psychiatry, London; Mark C. Coulson, PhD, Department of Psychology, School of Health and Education, Middlesex University, Hendon; Natasha Patel, MBBS, Elizabeth Highton-Williamson, BSc, Robert J. Howard, MD, King's College London, Department of Old Age Psychiatry, Institute of Psychiatry, London, UK.
Rebecca L
RL
Gould
Mark C
MC
Coulson
Natasha
N
Patel
Elizabeth
E
Highton-Williamson
Robert J
RJ
Howard
D000367:Age Factors; D000368:Aged; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001569:Benzodiazepines / Q000008:administration & dosage* / Q000009:adverse effects; D015982:Bias; D003131:Combined Modality Therapy / Q000379:methods; D004334:Drug Administration Schedule; D004363:Drug Utilization / Q000706:statistics & numerical data*; D006801:Humans; D016017:Odds Ratio; D010919:Placebos; D011613:Psychotherapy; D016032:Randomized Controlled Trials as Topic; D012044:Regression Analysis; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*
D014151:Anti-Anxiety Agents; D010919:Placebos; D001569:Benzodiazepines