Animal microsurgery using microfluidics.
Small multicellular genetic organisms form a central part of modern biological research. Using these small organisms provides significant advantages in genetic tractability, manipulation, lifespan and cost. Although the small size is generally advantageous, it can make procedures such as surgeries both time consuming and labor intensive. Over the past few years there have been dramatic improvements in microfluidic technologies that enable significant improvements in microsurgery and interrogation of small multicellular model organisms.
Carolina Institute for Developmental Disabilities, University of North Carolina, Chapel Hill, NC, USA; Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA; Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC, USA.
Jeffrey N
JN
Stirman
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK.
Bethany
B
Harker
School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Hang
H
Lu
SynthSys, University of Edinburgh, Edinburgh, UK. Electronic address: mcrane2@staffmail.ed.ac.uk.
Matthew M
MM
Crane
D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation / Q000379:methods; D044085:Microfluidics / Q000295:instrumentation / Q000379:methods*; D008866:Microsurgery / Q000295:instrumentation / Q000379:methods*