Methods for liposome-mediated gene transfer to tumor cells in vivo.
Despite considerable progress in the understanding of the molecular basis of cancer, many malignancies remain resistant to traditional forms of treatment. Certain cancers, such as melanoma or renal cell carcinoma, respond to modulation of immune function, presumably because the immune system is induced to recognize mutant proteins in tumor cells. The advent of cationic liposomes as safe and increasingly efficient vectors for gene transfer in vivo has allowed the development of new approaches to immunotherapy that offer alternative therapies for cancer in the future.
Departments of Internal Medicine and Biological Chemistry, Howard Hughes Medical Institution, University of Michigan Medical Center, Ann Arbor, MI.
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