Mechanisms of synaptic plasticity and recognition memory in the perirhinal cortex.
Learning is widely believed to involve synaptic plasticity, employing mechanisms such as those used in long-term potentiation (LTP) and long-term depression (LTD). In this chapter, we will review work on mechanisms of synaptic plasticity in perirhinal cortex in vitro and relate these findings to studies underlying recognition memory in vivo. We describe how antagonism of different glutamate and acetylcholine receptors, inhibition of nitric oxide synthase, inhibition of CREB phosphorylation, and interfering with glutamate AMPA receptor internalization can produce deficits in synaptic plasticity in vitro. Inhibition of each of these different mechanisms in vivo also results in recognition memory deficits. Therefore, we provide strong evidence that synaptic plastic mechanisms are necessary for the information processing and storage that underlies object recognition memory.
School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
P J
PJ
Banks
School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
E C
EC
Warburton
School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
M W
MW
Brown
School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom.
Z I
ZI
Bashir
D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D021641:Recognition, Psychology / Q000502:physiology*; D015398:Signal Transduction
Cholinergic; Familiarity; Glutamate; LTD; LTP; Medial temporal lobe