Association between the CYP1A1 T3801C polymorphism and risk of cancer: evidence from 268 case-control studies.
T3801C is a common polymorphism in CYP1A1, showing differences in its biological functions. Case-control studies have been performed to elucidate the role of T3801C in cancer, although the results are conflicting and heterogeneous. Hence, we performed a meta-analysis to investigate the association between cancer susceptibility and T3801C (55,963 cases and 76,631 controls from 268 studies) polymorphism in different inheritance models.We used odds ratios with 95% confidence intervals to assess the strength of the association. Overall, significantly increased cancer risk was observed in any genetic model (dominant model: odds ratio [OR]=1.14, 95% confidence interval [CI]=1.09–1.19; recessive model: OR=1.23, 95% CI=1.12–1.34; CC vs. TT: OR=1.31, 95% CI=1.19–1.45; TC vs. TT: OR=1.12, 95% CI=1.07–1.18; additive model: OR=1.14, 95% CI=1.09–1.19) when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, the elevated risk remained for subgroups of cervical cancer, head and neck cancer, hepatocellular cancer, leukemia, lung cancer, prostate cancer and breast cancer. In addition, significantly decreased colorectal cancer risk was also observed. In summary, this meta-analysis suggests that the participation of CYP1A1 T3801C is a genetic susceptibility for some cancer types.Moreover, our work also points out the importance of new studies for T3801C association in some cancer types, such as gallbladder cancer, Asians of acute myeloid leukemia, and thyroid cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the CYP1A1 T3801C polymorphism in cancer development.
Xiao-Feng
XF
He
Wu
W
Wei
Zhi-Zhong
ZZ
Liu
Xu-Liang
XL
Shen
Xian-Bin
XB
Yang
Su-Lan
SL
Wang
Dao-Lin
DL
Xie
D016022:Case-Control Studies; D016001:Confidence Intervals; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D012307:Risk Factors
C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1