Increased oxidative stress tolerance results in general stress tolerance in Candida albicans independently of stress-elicited morphological transitions.
A selection of tert-butylhydroperoxide (tBOOH)-tolerant Candida albicans mutants showed increased tolerances to 19 different stress conditions. These mutants are characterized by a constitutively upregulated antioxidative defense system and, therefore, adaptation to oxidative stress may play an important role in gaining general stress tolerance in C. albicans. Although C. albicans cells may undergo morphological transitions under various stress treatments, this ability shows considerable stress-specific and strain-specific variability and, hence, it is independent of mounting stress cross protections.
Department of Microbial Biotechnology and Cell Biology, Faculty of Science and Technology, University of Debrecen, P.O. Box 63, 4010, Debrecen, Hungary.
Ágnes
Á
Jakab
Károly
K
Antal
Ágnes
Á
Kiss
Tamás
T
Emri
István
I
Pócsi
D000222:Adaptation, Physiological / Q000235:genetics / Q000502:physiology*; D000975:Antioxidants / Q000502:physiology*; D002176:Candida albicans / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D008856:Microscopy, Fluorescence; D008858:Microscopy, Phase-Contrast; D009154:Mutation / Q000235:genetics / Q000502:physiology; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology*; D015854:Up-Regulation / Q000235:genetics / Q000502:physiology*
D000975:Antioxidants