Augmenting endothelial repair in diabetes: role of bone marrow-derived cells.
Endothelial loss, a consequence of both higher rates of apoptosis and diminished repair, is a major factor in the pathogenesis of diabetes complications. Although the repair process previously was viewed to arise primarily from the proliferation and migration of neighbouring endothelial cells, it now has become evident that certain bone marrow-derived cells contribute substantially to this process. Unfortunately, both the number and function of such cells are reduced in diabetes. Here, we first review the effects of current therapies on angiogenic bone marrow-derived cells and then explore future strategies to augment their number and function, aiming to reduce both the microvascular and macrovascular complications of diabetes.
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Ontario, Canada. Electronic address: richard.gilbert@utoronto.ca.
Richard E
RE
Gilbert
D001854:Bone Marrow Cells; D049109:Cell Proliferation; D064987:Cell- and Tissue-Based Therapy; D003324:Coronary Artery Disease / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D048909:Diabetes Complications / Q000503:physiopathology / Q000517:prevention & control*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D042783:Endothelial Cells / Q000637:transplantation*; D004730:Endothelium, Vascular / Q000637:transplantation*; D005260:Female; D006801:Humans; D008297:Male; D033581:Stem Cell Transplantation; D016896:Treatment Outcome; D040301:Vascular Endothelial Growth Factor Receptor-2
D040301:Vascular Endothelial Growth Factor Receptor-2
bone marrow; cellules progénitrices endothéliales; coronaropathie; coronary artery disease; endothelial progenitor cells; endothelium; endothélium; moelle osseuse; nephropathy; néphropathie; retinopathy; rétinopathie