Three new diterpenoid alkaloids from the roots of Aconitum duclouxii.
Three new C₁₉-diterpenoid alkaloids, ducloudines C (1), D (2), and E (3), were isolated from the roots of Aconitum duclouxii. Their structures were established on the basis of extensive spectroscopic analyses. Ducloudine C (1) is the first aconitine-type C₁₉-diterpenoid alkaloid with a C=O group at C-3 and a C=C bond between C-1 and C-2. All compounds were tested for their biological activities against one pathogenic fungi and two pathogenic bacteria.
a Key Laboratory of Medicinal Chemistry for Nature Resource , Ministry of Education, School of Chemical Science and Technology, Yunnan University , Kunming 650091 , China.
Tian-Peng
TP
Yin
Le
L
Cai
Jian-Min
JM
He
Jian-Wei
JW
Dong
Hai-Xian
HX
Fang
Hao
H
Zhou
Zhong-Tao
ZT
Ding
D000157:Aconitine / Q000737:chemistry / Q000302:isolation & purification; D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
D000470:Alkaloids; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C588344:ducloudine C; C588345:ducloudine D; C588346:ducloudine E; D000157:Aconitine