Specific noninvasive detection of Leishmania donovani in desquamated buccal cell swab samples from human visceral Leishmaniasis-HIV coinfected patients.
Diagnosis of human immunodeficiency virus (HIV) infection with visceral leishmaniasis (VL) coinfection is challenging. Specific diagnosis of VL in HIV-coinfected patients was evaluated by molecular methods in desquamated buccal swab samples, demonstrating 86.3% sensitivity and 98.3% specificity in controls. This test holds significant potential for development as a noninvasive diagnostic tool for VL in HIV-coinfected patients.
Department of Molecular Biology, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Patna, India.
Sushmita
S
Das
Avishek
A
Halder
Vidya Nand
VN
Rabidas
Abhishek
A
Mandal
Pradeep
P
Das
D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007893:Leishmania donovani / Q000302:isolation & purification*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis*; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D009061:Mouth Mucosa / Q000469:parasitology*; D010274:Parasitology / Q000379:methods; D012680:Sensitivity and Specificity