[Study on "multi-dimensional structure and process dynamics quality control system" of Danshen infusion solution based on component structure theory].
As traditional Chinese medicine (TCM) preparation products feature complex compounds and multiple preparation processes, the implementation of quality control in line with the characteristics of TCM preparation products provides a firm guarantee for the clinical efficacy and safety of TCM preparation products. Danshen infusion solution is a preparation commonly used in clinic, but its quality control is restricted to indexes of finished products, which can not guarantee its inherent quality. Our study group has proposed "multi-dimensional structure and process dynamics quality control system" on the basis of "component structure theory", for the purpose of controlling the quality of Danshen infusion solution at multiple levels and in multiple links from the efficacy-related material basis, the safety-related material basis, the characteristics of dosage form to the preparation process. This article, we bring forth new ideas and models to the quality control of TCM preparation products.
Key Laboratory of New Drug Delivery System of Traditional Chinese Medicine under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Liang
L
Feng
Key Laboratory of New Drug Delivery System of Traditional Chinese Medicine under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Ming-Hua
MH
Zhang
Key Laboratory of New Drug Delivery System of Traditional Chinese Medicine under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Jun-Fei
JF
Gu
Anhui Tianyang Pharmaceutical Co., Ltd., Tianchang 239304, China.
Gui-You
GY
Wang
Anhui Tianyang Pharmaceutical Co., Ltd., Tianchang 239304, China.
Zi-Yu
ZY
Zhao
Key Laboratory of New Drug Delivery System of Traditional Chinese Medicine under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
Xiao-Bin
XB
Jia
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology / Q000592:standards*; D006801:Humans; D051379:Mice; D010618:Phenanthrolines / Q000737:chemistry* / Q000494:pharmacology / Q000592:standards*; D011786:Quality Control; D027561:Salvia miltiorrhiza / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D010618:Phenanthrolines; C028972:dan-shen root extract