Autochthonous Dobrava-Belgrade virus infection in Eastern Germany.
A 21-year-old male patient from Borna, Saxony, in Eastern Germany, suffered from acute kidney injury (AKI) and symptoms typical for a hantavirus infection. These symptoms included nausea, vomiting, abdominal pain, diarrhea, and acute renal failure. Serological investigations by indirect IgM and IgG in-house ELISAs, commercial immunofluorescence and line assays, as well as chemiluminescence focus reduction neutralization assay confirmed an acute Dobrava-Belgrade virus (DOBV) infection of the patient. Serological and RT-PCR analyses of striped field mouse (Apodemus agrarius) trapped in a neighboring region of the residence of the patient identified an infection by DOBV, genotype Kurkino. This is the first report of an autochthonous DOBV infection in a German patient living far from the known endemic region in the north of the country. This finding has implications for the awareness of physicians in areas which are not recognized as hantavirus endemic regions but where the reservoir host of the virus is present.
Franz Maximilian
FM
Rasche
Sabrina
S
Schmidt
Christian
C
Kretzschmar
Marc
M
Mertens
Jörg
J
Thiel
Martin H
MH
Groschup
Mathias
M
Schlegel
Christof
C
Mayer
Tom H
TH
Lindner
Stephan
S
Schiekofer
Rainer G
RG
Ulrich
D000328:Adult; D000818:Animals; D004197:Disease Reservoirs / Q000821:virology; D019353:Endemic Diseases; D005858:Germany / Q000453:epidemiology; D006476:Orthohantavirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission / Q000821:virology*; D006801:Humans; D008297:Male; D051379:Mice; D055815:Young Adult