[IPS an ethical paradigm for biomedical research].
One of the greatest advances in molecular and cell biology was the discovery of the Induced Pluripotent Stem cells (iPS) in mice, by Shinya Yamanka and his team in 2006. The possibility that these cells can be generated also in humans opens up unexpected ways of development for biomedicine. Its main contribution is the creation of a strong protocol that takes into account three major advances in biology such as; nuclear transfer techniques, the discovery of transcription factors associated with pluripotency and the isolation of mouse embryonic stem cells. A protocol that can be easily replicated in other laboratories to have the oportunity to design tests that allow modeling of many incurable diseases, drug testing for human cells or explore the possibilities of autologous transplants of tissues or organs. Yamanaka ethical motivation to find an alternative to embryonic stem cells (ES) and prevent the destruction of embryos produced by In Vitro Fertilization techniques (IVF), has proved to be a research model, in which the intuition of the ethical principles and its application in advanced biotechnology projects, has meant the opening of a whole new way of understanding the biology of embryonic development. It is clear that development, biologically understood (puede ser también ″treated″; tratado), is not a one-way street. The possibilities to deepen into the foundations of molecular biology and genetics, along with the expectations of its clinical applications have earned Yamanka the Nobel Prize in Medicine 2012, along with another great scholar Sir John Gurdon, discoverer of nuclear transfer techniques.
Universidad Monteávila. 1060a Caracas. jgamez@uma.edu.ve.
José Antonio
JA
Gámez Escalona
D000818:Animals; D035843:Biomedical Research / Q000941:ethics* / Q000331:legislation & jurisprudence; D002454:Cell Differentiation; D002469:Cell Separation / Q000379:methods; D033041:Embryo Research / Q000941:ethics / Q000331:legislation & jurisprudence; D005307:Fertilization in Vitro / Q000941:ethics / Q000331:legislation & jurisprudence; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D057026:Induced Pluripotent Stem Cells; D051379:Mice; D053652:Nuclear Transfer Techniques / Q000941:ethics / Q000331:legislation & jurisprudence; D013045:Species Specificity; D057905:Stem Cell Research / Q000941:ethics / Q000266:history / Q000331:legislation & jurisprudence