Intramuscular capillary-type hemangioma: radiologic-pathologic correlation.
BACKGROUND
Infantile hemangiomas demonstrate a pattern of proliferative growth in infancy followed by a slow phase of involution. In contrast a rare type of vascular tumor, intramuscular capillary-type hemangioma, usually presents beyond the period of infancy with nonspecific symptoms and no evidence of involution.


OBJECTIVE
The purpose of this study was to characterize the clinical, imaging, histopathological characteristics and management of intramuscular capillary-type hemangioma.


METHODS
We performed a retrospective review of a 20-year period to identify children diagnosed with intramuscular capillary-type hemangioma. Patient demographics, imaging and histopathological findings were recorded.


RESULTS
We included 18 children (10 boys, 8 girls) with histologically proven intramuscular capillary-type hemangioma - and adequate imaging. The mean age at presentation was 8.1 years (range 1 day to 19 years). Twelve lesions involved muscles of the extremities, 4 were located in the trunk and 2 were in the head and neck. MRI had been performed in all children and demonstrated a soft-tissue mass with flow voids, consistent with fast flow. The lesion was well-circumscribed in 16 children and intralesional fat was seen in 14. Doppler US demonstrated a heterogeneous lesion, predominantly isoechoic to surrounding muscle, with enlarged arterial feeders. Enlarged feeding arteries, inhomogeneous blush and lack of arteriovenous shunting were noted on angiography (n = 5). The most common histopathological findings were lobules of capillaries with plump endothelium and at least some adipose tissue. The lesions were excised in six children. Two children were lost to follow-up. In the remaining 10, follow-up MRI studies ranging from 3 months to 10 years showed that the lesion enlarged in proportion to the child (n = 7), demonstrated slow growth (n = 2) or remained stable (n = 1). There was no change in imaging characteristics on follow-up.


CONCLUSIONS
Intramuscular capillary-type hemangioma is a rare benign vascular tumor of skeletal muscle. The most typical imaging features show a heterogeneous intramuscular mass with fast flow, and intralesional fat. Although the lesion is relatively stable in appearance over time, imaging does not obviate the need for a biopsy to rule out sarcoma. The diagnosis can usually be established by typical findings on histopathology.
Vascular Anomalies Center, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.
Sabri
S
Yilmaz
Harry P
HP
Kozakewich
Ahmad I
AI
Alomari
Steven J
SJ
Fishman
John B
JB
Mulliken
Gulraiz
G
Chaudry
D000293:Adolescent; D017677:Age Distribution; D001900:Boston / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D018324:Hemangioma, Capillary / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D018810:Magnetic Resonance Angiography / Q000706:statistics & numerical data*; D008297:Male; D019042:Muscle Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D035583:Rare Diseases / Q000175:diagnosis / Q000453:epidemiology; D012307:Risk Factors; D017678:Sex Distribution; D014463:Ultrasonography / Q000706:statistics & numerical data*; D055815:Young Adult