Altered behavior associated with damage to the ventromedial hypothalamus: a distinctive syndrome.
An adult manifested a tetrad of neurobehavioral findings consisting of episodic rage, emotional lability, hyperphagia with obesity, and memory impairment with intellectual decline following surgical removal of a craniopharyngioma. Post-mortem investigation of the topography of the lesion as well as review of previously reported cases suggest that this tetrad represents a specific neurobehavioral syndrome referable to damage to the ventromedial hypothalamus.
Neurobehavior Unit, West Los Angeles Veterans Administration Medical Center Departments of Neurology and Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California, 90073 U.S. Army AMEDD Student Detachment, Academy of Health Sciences, Ft. Sam Houston, Texas.
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Flynn
Neurobehavior Unit, West Los Angeles Veterans Administration Medical Center Departments of Neurology and Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California, 90073.
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Cummings
Laboratory Service (Neuropathology), West Los Angeles Veterans Administration Medical Center.
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Tomiyasu