Nanostructuring carbon fibre probes for use in central venous catheters.
A carbon fibre probe is described which utilises the oxidation of an endogenous biomarker to provide diagnostic information on the condition of intravascular access lines. The probe surface was modified through anodic oxidation to provide a high selectivity towards urate which was used as a redox probe through which the pH could be determined. A Nernstian response (-60 mV/pH) was obtained which was free from the interference of other redox species common to biofluids. The electroanalytical performance of the probe has been optimised and the applicability of the approach demonstrated through testing the responses in whole blood.
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Meixian
M
Li
School of Engineering, University of Ulster, Jordanstown, Northern Ireland BT37 0QB, UK.
Jolene
J
Phair
Lifescan Scotland Ltd, Beechwood Park North, Inverness IV2 3ED, UK.
Marco F
MF
Cardosi
School of Engineering, University of Ulster, Jordanstown, Northern Ireland BT37 0QB, UK. Electronic address: james.davis@ulster.ac.uk.
James
J
Davis
D002244:Carbon / Q000737:chemistry*; D062905:Central Venous Catheters; D015335:Molecular Probes; D049329:Nanostructures
D015335:Molecular Probes; D002244:Carbon
Biofilm; Carbon fibre; Catheter; Infection; Uric acid; pH