[Effects of parenterally administered shenqi fuzheng on patient outcomes with tumor using propensity score].
OBJECTIVE
Use propensity score methods to explore the effect of parenterally administered Shenqi Fuzheng on clinical outcome of patients with tumor.


METHODS
HIS data from 20 hospitals was analyzed. Patients suffering from malignant tumor, ranging from 18 to 80 years, Were divided into the treatment group and control group. The treatment group was given parenterally administered Shenqi Fuzheng, the control group received other parenterally administered anti-cancer medicines. Various levels of controls for confounding factors were applied, including chi-square test, Fisher exact test, stratified analysis, logistic regression, and logistic regression based on adjusted propensity score, to assess parenterally administered Shenqi Fuzheng's clinical effects.


RESULTS
Stratified analysis showed that among elderly patients whose condition was classified as either 'urgent' or 'dangerous'. Comparing these two sub-groups it was found that the test P < 0.05. The treatment group had a significantly lower mortality rate than the control group. After adjusting for 72 confounding factors, the statistical results also show that the mortality rate overall in the treatment group was significantly lower than in the control group.


CONCLUSIONS
Analysis of HIS data showed that parenterally administered Shenqi Fuzheng can reduce mortality due to malignant cancer when compared to other available treatments.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. aimly28@163.com
Qing-Hua
QH
Ai
Renmin University of China, Beijing 100872, China.
Xian-Bin
XB
Zeng
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yan-Ming
YM
Xie
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006751:Hospital Information Systems / Q000706:statistics & numerical data; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000188:drug therapy* / Q000401:mortality; D017063:Outcome Assessment, Health Care; D064792:Pragmatic Clinical Trials as Topic; D057216:Propensity Score; D016896:Treatment Outcome; D055815:Young Adult
D004365:Drugs, Chinese Herbal; C521737:shenqi fuzheng