Computational investigation of pkcβ inhibitors for the treatment of diabetic retinopathy.
Diabetic Retinopathy (DR) is one of the attenuating complications of diabetes mellitus. The key gene responsible for causing diabetic retinopathy is protein kinase C beta (PKCβ). Protein kinase C is a family of protein kinase enzymes which are involved in controlling the function of other proteins through phosphorylation mechanism and plays a crucial role in signal transduction mechanisms. Among all the PKC isoenzymes, PKCβ could be a significant isoenzyme involved in vascular dysfunction during hyperglycemia. Studies show that oral administration of PKCβ inhibitor Ruboxistaurin (LY333531), decreases vessel permeability and improves retinal condition. Thus compounds that decrease the PKCβ activation would be helpful in the treatment of diabetic retinopathy. The compounds similar to Ruboxistaurin are taken from Super Target database and docking analysis was performed. Maleimide derivative 3 showed highest binding affinities compared to Ruboxistaurin and so we advise that compound may be utilized in the treatment of diabetic retinopathy.
Department of IT, GITAM University,Patancheru Mandal,Medak Dist-502329.
Susmitha Valli
SV
Gogula
Pydah College of Engineering and Technology, Gambheeram, Anandapuram (M); Visakhapatnam-531163.
Ch
Ch
Divakar
Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh-533003.
Ch
Ch
Satyanarayana
Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh-533003.
Yedla Phani
YP
Kumar
Jawaharlal Nehru Technological University Kakinada, Kakinada, Andhra Pradesh-533003.
Vadapalli Santhosi
VS
Lavanaya
Diabetic retinopathy (DR); Diacylglycerol (DAG); PKCβ; Ruboxistaurin