Methods for the discovery of new anti-aging products--targeted approaches.
BACKGROUND
Aging is considered to be one of the most complicated and heterogeneous phenomena and is the main risk factor for most chronic diseases, disabilities and declining health. Aging cells cease to divide and drive the progression of illness through various pathways. Over the years, a number of anti-aging medicines of natural and synthetic origin have been introduced. Indeed, some studies have identified senescent cells as potential therapeutic targets in the treatment of aging and age-related diseases.


METHODS
In this review, the authors highlight and critically review the possible mechanisms of the aging process and related illnesses. The authors give particular attention to illnesses, including Alzheimer's disease, Parkinson's disease, skin aging and cardiovascular diseases.


CONCLUSIONS
Several reports have highlighted that mitochondria are a key factor in the progression of aging and neurodegenerative illnesses. This is due to their production of extra amounts of reactive oxygen species, which leads into progressive caspase-dependent apoptosis and cell death. Therefore, strategies to prevent/reduce oxidative stress-mediated aging, whether environmental, nutritional and pharmacological, need to be taken into account. Presently, Drosophila melanogaster and Caenorhabditis elegans, which focus on the evolutionary and genetic foundations of aging, have helped to establish the screening of several synthetic and natural compounds with large cohorts in a quick manner. However, there is yet to be any efficient experimental evidence to prove the exact role of senescent cells in age-related dysfunction and further studies are required to better understand these processes.
Tehran University of Medical Sciences, Faculty of Pharmacy, Medicinal Plants Research Center , Tehran 1417614411 , Iran.
Azadeh
A
Manayi
Soodabeh
S
Saeidnia
Ahmad Reza
AR
Gohari
Mohammad
M
Abdollahi
D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism; D055808:Drug Discovery; D006801:Humans; D010300:Parkinson Disease / Q000209:etiology / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects