Copper-catalyzed domino addition/double cyclization: an approach to polycyclic benzimidazole derivatives.
An efficient and versatile method for the assembly of novel polycyclic benzimidazole derivatives has been developed by Cu-catalyzed domino addition/double cyclization reactions. A wide variety of polycyclic benzimidazole derivatives, which might be used as synthetic medicines and functional materials, were successfully assembled from bis-(o-haloaryl)carbodiimides. Unexpected N-methylated benzo[4,5]imidazo[1,2-a]indoles can also be selectively assembled. Multibonds and polycyclic moieties were conveniently formed in one pot during these domino processes.
Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and Life Sciences, Zhejiang Normal University , Jinhua 321004, People's Republic of China.
Guodong
G
Yuan
Haiquan
H
Liu
Jilong
J
Gao
Kangjian
K
Yang
Qingsheng
Q
Niu
Hui
H
Mao
Xiaoxia
X
Wang
Xin
X
Lv
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D007211:Indoles / Q000737:chemistry; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*
D001562:Benzimidazoles; D007211:Indoles; D011083:Polycyclic Compounds; D003300:Copper; C031000:benzimidazole