Intra-tumor distribution of metallofullerene using micro-particle induced X-ray emission (PIXE).
To clarify the intra tumor distribution of gadlinium containing fullerene (Gd@C82), micro particle induced X-ray emission (Micro-PIXE) analysis were performed. The tumor bearing BALB/c mice were injected Gd@C82 and subcutaneous tumors were taken from 48h after the intravenous injection. Using the Micro-PIXE method, we could visualize Gd intra tumor distribution. Therefore our results indicate the possibility that Micro-PIXE is useful technique for imaging the bioditribution of Gd, and Gd@C82 is potentially useful Gd carrier for NCT.
Department of Neurosurgery, Graduated School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Yohei
Y
Yamamoto
Department of Neurosurgery, Graduated School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Tetsuya
T
Yamamoto
Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan.
Yukichi
Y
Horiguchi
Department of Neurosurgery, Graduated School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Makoto
M
Shirakawa
Department of Advanced Radiation Technology, Japan Atomic Energy Agency (JAEA), 1233 Watanuki-machi, Takasaki, Gunma 370-1292, Japan.
Takahiro
T
Satoh
Department of Advanced Radiation Technology, Japan Atomic Energy Agency (JAEA), 1233 Watanuki-machi, Takasaki, Gunma 370-1292, Japan.
Masashi
M
Koka
Department of Materials Science, Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573, Japan.
Yukio
Y
Nagasaki
Department of Neurosurgery, Graduated School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan. Electronic address: knakai@md.tsukuba.ac.jp.
Kei
K
Nakai
Department of Neurosurgery, Graduated School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Akira
A
Matsumura
D000818:Animals; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000473:pathology*; D037741:Fullerenes / Q000737:chemistry* / Q000627:therapeutic use; D005682:Gadolinium / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D008863:Microspheres; D013052:Spectrometry, X-Ray Emission / Q000379:methods*
D037741:Fullerenes; D005682:Gadolinium
Biodistribution; Fullerene; Gd@C(82); Metallofullerene; Micro-Particle Induced X-ray Emission (Micro-PIXE); Neutron Capture Therapy (NCT)