Emerging roles of Jab1/CSN5 in DNA damage response, DNA repair, and cancer.
Jab1/CSN5 is a multifunctional protein that plays an important role in integrin signaling, cell proliferation, apoptosis, and the regulation of genomic instability and DNA repair. Dysregulation of Jab1/CSN5 activity has been shown to contribute to oncogenesis by functionally inactivating several key negative regulatory proteins and tumor suppressors. In this review, we discuss our current understanding of the relationship between Jab1/CSN5 and DNA damage and summarize recent findings regarding opportunities for and challenges to therapeutic intervention.
Department of Systems Biology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Department of Pathophysiology; Zhongshan School of Medicine; Sun Yat-Sen University; Guangzhou, Guangdong, PR China; Breast Tumor Center; Sun Yat-Sen Memorial Hospital; Sun Yat-Sen University; Guangzhou, Guangdong, PR China.
Yunbao
Y
Pan
Department of Pathophysiology; Zhongshan School of Medicine; Sun Yat-Sen University; Guangzhou, Guangdong, PR China.
Huiling
H
Yang
Department of Systems Biology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; Experimental Therapeutic Academic Program and Cancer Biology Program; The University of Texas Graduate School of Biomedical Sciences at Houston; Houston, TX USA.
Francois X
FX
Claret
D000075686:COP9 Signalosome Complex; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism*
D047908:Intracellular Signaling Peptides and Proteins; D004247:DNA; D010447:Peptide Hydrolases; C501488:COPS5 protein, human; D000075686:COP9 Signalosome Complex
DNA damage; Jab1/CSN5; genomic instability; therapeutic approach; tumorigenesis