Terpenoids from the roots of Drypetes hoaensis and their cytotoxic activities.
Seven terpenoids consisting of five sesquiterpenoids, hoaensieremone, hoaensieremodione, hoaensifuranonal, hoaensieudesone, and hoaensibenzofuranal, and two friedelane triterpenoids, 3α-(E)-p-coumaroyloxyfriedelan-7-one and 3α-(E)-caffeoyloxyfriedelan-7-one were isolated from the dichloromethane extract of the roots of Drypetes hoaensis. Additionally, twelve known compounds and vanillin were isolated. Their structures were established on the basis of spectroscopic analysis, as well as by comparison with literature data. The anticancer activity of nine of these compounds was investigated.
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Sawangjitt
S
Wittayalai
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand; Chulabhorn Graduate Institute and Center for Environmental Health and Toxicology (EHT), Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Chulabhorn
C
Mahidol
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Vilailak
V
Prachyawarakorn
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand. Electronic address: hunsa@cri.or.th.
Hunsa
H
Prawat
Chulabhorn Research Institute, Kamphaeng Phet 6 Road, Bangkok 10210, Thailand; Chulabhorn Graduate Institute and Center for Environmental Health and Toxicology (EHT), Kamphaeng Phet 6 Road, Bangkok 10210, Thailand.
Somsak
S
Ruchirawat
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes
Cytotoxicities; Drypetes hoaensis; Eremophilane; Eudesmane; Euphorbiaceae; Friedelane; Lignan; Roots; Steroid