miRNA423-5p regulates cell proliferation and invasion by targeting trefoil factor 1 in gastric cancer cells.
TFF1 is a small, secreted protein in the TFF family that has a pivotal role as a motogenic factor in epithelial restitution and cell motility, and as a tumor suppressor gene in the stomach. In this study, we identified TFF1 as a novel target gene of miRNA-423-5p. miRNA-423-5p negatively regulated the expression of TFF1 by binding to its 3'UTR and participated in proliferation/invasion-related processes via a TFF1-dependent manner in gastric cancer cells. Our findings suggested that miR-423-5p may be a novel target for the future development of specific therapeutic interventions for gastric cancer.
Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, Fujian Province, PR China.
Jingjing
J
Liu
Faculty of Clinical Medicine, Medical College of Xiamen University, Xiamen 361005, Fujian Province, PR China.
Xu
X
Wang
Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, Fujian Province, PR China.
Xiaoning
X
Yang
Faculty of Clinical Medicine, Medical College of Xiamen University, Xiamen 361005, Fujian Province, PR China.
Yunpeng
Y
Liu
Faculty of Clinical Medicine, Medical College of Xiamen University, Xiamen 361005, Fujian Province, PR China.
Ying
Y
Shi
Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, Fujian Province, PR China; Faculty of Clinical Medicine, Medical College of Xiamen University, Xiamen 361005, Fujian Province, PR China. Electronic address: renjianl@xmu.edu.cn.
Jianlin
J
Ren
Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen 361004, Fujian Province, PR China; Faculty of Clinical Medicine, Medical College of Xiamen University, Xiamen 361005, Fujian Province, PR China. Electronic address: bayasi@xmu.edu.cn.
Bayasi
B
Guleng
D001483:Base Sequence; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D056741:Cyclin D / Q000378:metabolism; D017931:DNA Primers; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D009361:Neoplasm Invasiveness; D016133:Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism
D056741:Cyclin D; D017931:DNA Primers; C548900:MIRN423 microRNA, human; D035683:MicroRNAs; C051838:TFF1 protein, human; D000071163:Trefoil Factor-1; D025521:Tumor Suppressor Proteins; D051176:beta Catenin
Expression regulation; Gastric cancer; Proliferation and invasion; Trefoil factor 1 (TFF1); miR-423-5p