[Clinical experience on treating Toxoplasma gondii infection during pregnancy by using acetyl spiramycin combined with azithromycin].
OBJECTIVE
To explore an effective therapy for pregnant Toxoplasma gondii infection by using acetyl spiramycin combined with azithromycin.


METHODS
ELISA and PCR were used to diagnose and evaluate the therapy efficiency to toxoplasmosis in pregnant women.


RESULTS
The serological test showed that the positive rates of specific antibodies IgM and IgG to Toxoplasma gondii in 285 pregnant women were 1.05% (3/285) and 5.97% (17/285), respectively. All the 3 cases of serum IgM positive pregnant women received the amniotic fluid PCR tests for Toxoplasma gondii DNA and 2 were positive, and they received spiramycin combined with azithromycin. After the therapy, their serum IgM antibody specific to Toxoplasma gondii and positive amniotic fluid PCR test for Toxoplasma gondii DNA turned to be negative.


CONCLUSIONS
Acetyl spiramycin in combination with azithromycin is effective in the treatment of pregnant toxoplasmosis.
Heshan District Maternal and Child Health Hospital of Yiyang City in Hunan Province, Yiyang 413002, China.
Hong-xia
HX
Tang
Heshan District Maternal and Child Health Hospital of Yiyang City in Hunan Province, Yiyang 413002, China.
Xue-feng
XF
Xiong
National Institute of Parasitic Diseases, Chinese Centre for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, China.
Zhi-qiang
ZQ
Qin
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017963:Azithromycin / Q000008:administration & dosage*; D016054:DNA, Protozoan / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007933:Leucomycins / Q000008:administration & dosage*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy*; D015572:Spiramycin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014123:Toxoplasmosis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D016054:DNA, Protozoan; D007933:Leucomycins; C033163:acetylspiramycin; D015572:Spiramycin; D017963:Azithromycin