[Treatment and prognosis of sinonasal mucosal melanoma].
OBJECTIVE
To evaluate the treatment and prognosis of sinonasal mucosal melanoma (SMM).


METHODS
Clinicopathological data of SMM patients from January 1976 to December 2005 were analyzed retrospectively. Survival analysis was performed and Kaplan-Meier analysis was used to compare the effect of clinicopathological factors on survival using SPSS 18.0 software. A Cox model was applied for multivariate analysis.


RESULTS
The 3-year and 5-year overall survival (OS) rates of 68 cases of SMM were 36.1% and 29.4%, respectively. The 3-year and 5-year OS of patients who underwent surgery or biotherapy were significantly higher than that of patients who underwent other therapeutic regimens without surgery or without biotherapy, respectively. Multivariate analysis showed the patients with distant metastasis at first present or residual/recurrence had a worse prognosis than that without distant metastasis or residual/recurrence, respectively. Surgery and biotherapy were effective treatments for SMM.


CONCLUSIONS
SMM has a poor prognosis, especially in the patients with distant metastasis or residual/recurrence. Surgery or biotherapy may improve the prognosis of patients with SMM.
Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
Chuanzheng
C
Sun
Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
Zedong
Z
Hu
Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
Hu
H
Wang
Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
Yan
Y
Xi
Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
Guoping
G
Li
Department of Head and Neck Surgery, Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
Liufang
L
Zhao
Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Ankui
A
Yang
Department of Head and Neck Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
Qiuli
Q
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000628:therapy; D008875:Middle Aged; D009297:Nasal Mucosa; D009669:Nose Neoplasms / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult