Cells derived from iPSC can be immunogenic - yes or no?
The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming factors in somatic cells, can potentially provide unlimited autologous cells for regenerative medicine. In theory, the autologous cells derived from patient iPSCs should be immune tolerant by the host without any immune rejections. However, our recent studies have found that even syngeneic iPSC-derived cells can be immunogenic in syngeneic hosts by using a teratoma transplantation model (Nature 474:212-215, 2011). Recently two research groups differentiated the iPSCs into different germ layers or cells, transplanted those cells to the syngeneic hosts, and evaluated the immunogenicity of those cells. Both of the two studies support our conclusions that some certain but not all tissues derived from iPSCs can be immunogenic, although they claimed either "negligible" or "lack of" immunogenicity in iPSC derivatives (Nature 494:100-104, 2013; Cell Stem Cell 12:407-412, 2013). To test the immunogenicity of clinically valuable cells differentiated from human iPSCs are emergently required for translation of iPSC technology to clinics.
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.
Jiani
J
Cao
Xiaoyan
X
Li
Xiao
X
Lu
Chao
C
Zhang
Honghao
H
Yu
Tongbiao
T
Zhao
D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D017690:Cell Transplantation / Q000379:methods*; D006084:Graft Rejection / Q000276:immunology; D057026:Induced Pluripotent Stem Cells / Q000276:immunology* / Q000637:transplantation*; D008565:Membrane Proteins / Q000378:metabolism; D018345:Mice, Knockout; D013724:Teratoma / Q000276:immunology* / Q000378:metabolism
D018797:Cell Cycle Proteins; D008565:Membrane Proteins; C506693:Nohma protein, mouse; C487135:ZG-16 protein, mouse