[Progress in researches of molecular mechanism of schistosome cercariae infection].
Schistosome cercariae must penetrate skin as an initial step to successfully infect the final host. Proteolytic enzymes secreted from the acetabular glands of cercariae contribute significantly to the invasion process. Nowadays, the researches of molecular mechanism of schistosome infection mainly focus on the cercarial secretions including serine protease and cysteine protease. Previous researches already showed that Schistosoma mansoni penetrates the skin mainly depend on cercarial elastease secreted by cercariae while Schistosoma japonicum penetrates the skin chiefly by cathepsin B2. The illustration of molecular mechanism of schistosome cecariae infection will accelerate the identification of novel vaccines and drug targets.
Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China.
Xiaofeng
X
Du
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology of Ministry of Health, WHO Collaborating Center for Malaria, Schistosomiasis and Filariasis, China.
Chuan
C
Ju
Department of Microbiology and Microbial Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China.
Wei
W
Hu
D000818:Animals; D058487:Cercaria / Q000378:metabolism; D057056:Cysteine Proteases / Q000502:physiology; D006801:Humans; D012547:Schistosoma / Q000201:enzymology; D012552:Schistosomiasis / Q000209:etiology*; D057057:Serine Proteases / Q000502:physiology
D057056:Cysteine Proteases; D057057:Serine Proteases