Case for diagnosis. Granular cell tumor.
Granular cell tumor is a rare benign neoplasm of neural origin. We report the case of a female patient, 27 years old presenting a brown-red nodule in the right arm, which pathological examination showed to be formed by polygonal cells with eosinophilic granular cytoplasm and immunohistochemistry positive for S100 protein and CD68. Granular cell tumor is usually solitary and in half the cases located in the head and neck areas, 30% of these in the tongue. It is most frequent between the third and fifth decades of life in women and people of African-American ethnicity. Its origination is controversial, including the possible origins in muscle, fibroblasts, neural crest, neural sheath or histiocytes. The positivity for S-100 and CD68 suggest the neural origin.
Dermatology Service, Pará Federal University, BelémPA, Brazil, MD, Dermatology resident at the Dermatology Service at Pará Federal University (UFPA)- Belém (PA), Brazil.
Thaiane Lima
TL
Lage
Pará Federal University, Medical School, BelémPA, Brazil, MD, Dermatologist, Dermatopathologist - Adjunct Professor of Dermatology at Pará Federal University (UFPA) Medical School - Belém (PA), Brazil.
Mario Fernando Ribeiro de
MF
Miranda
Pará Federal University, BelémPA, Brazil, MD, MSc in tropical diseases - Assistant Professor of dermatology at Pará Federal University(UFPA) and State Universitary Center of Pará (CESUPA) - Belém (PA), Brazil.
Maraya de Jesus Semblano
Mde J
Bittencourt
Dermatology Service, Pará Federal University, BelémPA, Brazil, MD, Dermatology resident at the Dermatology Service at Pará Federal University (UFPA)- Belém (PA), Brazil.
Carolina Moraes
CM
Dias
MD, Dermatologist - Private Practice - Belém (PA), Brazil.
Amanda Magno de
AM
Parijós
Santa Casa de Misericórdia do Pará Foundation, BelémPA, Brazil, MD, Internal Medicine Resident at Santa Casa de Misericórdia do Pará Foundation (FSCMPA) - Belém (PA), Brazil.
Theisla Kely Azevedo
TK
Raiol
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D016586:Granular Cell Tumor / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000473:pathology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule