Spatially Fourier-encoded photoacoustic microscopy using a digital micromirror device.
We have developed spatially Fourier-encoded photoacoustic (PA) microscopy using a digital micromirror device. The spatial intensity distribution of laser pulses is Fourier-encoded, and a series of such encoded PA measurements allows one to decode the spatial distribution of optical absorption. The throughput and Fellgett advantages were demonstrated by imaging a chromium target. By using 63 spatial elements, the signal-to-noise ratio in the recovered PA signal was enhanced by ∼4×. The system was used to image two biological targets, a monolayer of red blood cells and melanoma cells.
Jinyang
J
Liang
Liang
L
Gao
Chiye
C
Li
Lihong V
LV
Wang
D000042:Absorption; D000818:Animals; D002417:Cattle; D004912:Erythrocytes / Q000166:cytology; D005583:Fourier Analysis; D008546:Melanoma, Experimental / Q000473:pathology; D008853:Microscopy / Q000295:instrumentation*; D055616:Microtechnology / Q000295:instrumentation*; D061088:Photoacoustic Techniques / Q000295:instrumentation*; D059629:Signal-To-Noise Ratio