Enantioselective hydroacylation of N-vinylindole-2-carboxaldehydes.
We report catalytic, enantioselective intramolecular hydroacylation of N-vinylindole-2-carboxaldehydes. These hydroacylation reactions occur in the presence of a readily accessible rhodium catalyst and form chiral, non-racemic 2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-ones in high yields with excellent enantioselectivities.
Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA. lstanley@iastate.edu.
Avipsa
A
Ghosh
Levi M
LM
Stanley