Six new tetraprenylated alkaloids from the South China Sea gorgonian Echinogorgia pseudossapo.
Six new tetraprenylated alkaloids, designated as malonganenones L-Q (1-6), were isolated from the gorgonian Echinogorgia pseudossapo, collected in Daya Bay of Guangdong Province, China. The structures of 1-6 featuring a methyl group at N-3 and a tetraprenyl chain at N-7 in the hypoxanthine core were established by extensive spectroscopic analyses. Compounds 1-6 were tested for their inhibitory activity against the phosphodiesterases (PDEs)-4D, 5A, and 9A, and compounds 1 and 6 exhibited moderate inhibitory activity against PDE4D with IC₅₀ values of 8.5 and 20.3 µM, respectively.
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China. sysuszh@126.com.
Zhang-Hua
ZH
Sun
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China. caiyinghong88@163.com.
Ying-Hong
YH
Cai
East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China. chengqifan92@pku.org.cn.
Cheng-Qi
CQ
Fan
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China. tanggh5@mail.sysu.edu.cn.
Gui-Hua
GH
Tang
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China. luohb77@mail.sysu.edu.cn.
Hai-Bin
HB
Luo
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China. yinsh2@mail.sysu.edu.cn.
Sheng
S
Yin
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000470:Alkaloids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D002681:China; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000187:drug effects; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5 / Q000187:drug effects; D020128:Inhibitory Concentration 50; D009792:Oceans and Seas; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis
D000470:Alkaloids; D010726:Phosphodiesterase Inhibitors; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5