The gene polymorphism of LOX1 predicts the incidence of LVH in patients with essential hypertension.
BACKGROUND
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) has been shown to play an important role in cardiac remodeling under different pathologic conditions. The role of genetic polymorphisms in the LOX1 gene, however, remains unclear in the development of left ventricular hypertrophy (LVH) for patients with hypertension.


METHODS
A total of 536 patients diagnosed with essential hypertension (EH) were recruited in this study. Patients were assigned to the LVH+ (n=143) and LVH- (n=393) groups, respectively. The serum LOX1 level was measured and three single nucleotide polymorphisms (SNPs), i.e. intron 4 (G→A), intron 5(T→G), and 3' UTR (T→C) of the LOX1 gene were genotyped.


RESULTS
The genotype frequencies of intron 4 G>A and 3'UTR T>C were not significantly different between the LVH+ and LVH- groups (both P>0.05), however, frequencies of 501G>C were significantly different between those two groups (P=0.007). The 501CC genotype carriers had a markedly higher serum LOX1 level and an increased risk to develop LVH (adjusted OR=2.444, adjusted P=0.002). There was a positive correlation between serum LOX1 level and left ventricular mass index (r=0.907, P<0.001); a cutoff value of 1.0 ng/mL for sLOX-1 was applied to significantly differentiate the LVH+ patients from the LVH- patients with 84% sensitivity and 86% specificity.


CONCLUSIONS
Our data suggest that both the 501>C SNP in the LOX1 gene and the serum LOX1 level may be used to predict the development of LVH among EH patients.
Department of Cardiothoracic Surgery, Huashan Hospital, Fudan University, Shanghai, China.
Xiaolin
X
Xu
Xuwei
X
Hou
Yixiu
Y
Liang
Fan
F
Li
Liewen
L
Pang
Guoqian
G
Huang
Jiechun
J
Huang
Meng
M
Shi
Xiaotian
X
Sun
Yiqing
Y
Wang
D002097:C-Reactive Protein / Q000378:metabolism; D000075222:Essential Hypertension; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000150:complications* / Q000235:genetics*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012372:ROC Curve; D051127:Scavenger Receptors, Class E / Q000235:genetics*
C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E; D002097:C-Reactive Protein