Circulating levels of adipokines in Parkinson's disease.
BACKGROUND
Adipokines are adipocyte-derived secretory factors, which have functions in satiety, energetic homeostasis, insulin sensitivity, vascular disease and also immune response. Parkinson's disease (PD) has been associated with unintended weight loss and reduced prevalence of cardiovascular risk factors. In addition, inflammation has been proposed as one of the factors contributing to PD pathophysiology. Therefore, we sought to investigate if adipokine levels - adiponectin, leptin and resistin - are altered in PD patients. Also, we aimed to evaluate association between adipokine levels and clinical variables in PD.


METHODS
Forty PD patients and twenty-five age-, gender- and body mass index-matched controls were enrolled in this study. Peripheral blood was drawn and plasma levels of adiponectin, leptin and resistin were measured by Enzyme-Linked Immunosorbent Assay.


RESULTS
There was no significant difference between PD patients and controls regarding plasma levels of the evaluated adipokines. In PD patients, higher leptin levels were associated with increased age and body mass index. No other correlation was found between adipokine levels and clinical or demographic data.


CONCLUSIONS
Although adipokines play important roles in inflammation, it seems that they are not implicated in the inflammatory response associated with PD.
Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Laboratório de Neurofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: npessoarocha@gmail.com.
Natália Pessoa
NP
Rocha
Laboratório de Neurobiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Paula Luciana
PL
Scalzo
Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Izabela Guimarães
IG
Barbosa
Departamento de Neurologia e Neurocirurgia, Santa Casa de Belo Horizonte Hospital, Belo Horizonte, Brazil.
Mariana Soares
MS
de Sousa
Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil; Laboratório de Neurofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Isabela Boechat
IB
Morato
Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Erica Leandro Marciano
EL
Vieira
Departamento de Neurologia e Neurocirurgia, Santa Casa de Belo Horizonte Hospital, Belo Horizonte, Brazil.
Paulo Pereira
PP
Christo
Laboratório de Neurofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Helton José
HJ
Reis
Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: altexr@gmail.com.
Antônio Lúcio
AL
Teixeira
D054392:Adipokines / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000175:diagnosis*
D054392:Adipokines; D015415:Biomarkers
Adipokines; Adiponectin; Inflammation; Leptin; Parkinson's disease; Resistin