Nocturnal hypoxemia in children and adolescents with cystic fibrosis.
To determine the prevalence of nocturnal hypoxemia and its association with pulmonary function, nutritional status, sleep macrostructure, and obstructive respiratory events during sleep in a population of clinically stable children and adolescents with cystic fibrosis (CF).



This was a cross-sectional study involving 67 children and adolescents with CF between 2 and 14 years of age. All of the participants underwent polysomnography, and SpO2 was measured by pulse oximetry. We also evaluated the Shwachman-Kulczycki (S-K) scores, spirometry findings, and nutritional status of the patients.



The study involved 67 patients. The mean age of the patients was 8 years. The S-K scores differed significantly between the patients with and without nocturnal hypoxemia, which was defined as an SpO2 < 90% for more than 5% of the total sleep time (73.75 ± 6.29 vs. 86.38 ± 8.70; p < 0.01). Nocturnal hypoxemia correlated with the severity of lung disease, FEV1 (rs = -0.42; p = 0.01), FVC (rs = -0.46; p = 0.01), microarousal index (rs = 0.32; p = 0.01), and apnea-hypopnea index (rs = 0.56; p = 0.01).



In this sample of patients with CF and mild-to-moderate lung disease, nocturnal oxygenation correlated with the S-K score, spirometry variables, sleep macrostructure variables, and the apnea-hypopnea index.
Federal University of Bahia School of Medicine, Department of Pediatrics, Salvador, Brazil.
Regina Terse Trindade
RT
Ramos
Bahia State Referral Center for Cystic Fibrosis, Salvador, Brazil.
Maria Angélica Pinheiro
MA
Santana
Federal University of Bahia School of Medicine, Department of Pediatrics, Salvador, Brazil.
Priscila de Carvalho
Pde C
Almeida
Bahia Foundation for Science Development, Bahia School of Medicine and Public Health, Salvador, Brazil.
Almério de Souza
Ade S
Machado
Federal University of Bahia, Collective Health Institute, Salvador, Brazil.
José Bouzas
JB
Araújo-Filho
Federal University of Bahia, School of Medicine, Salvador, Brazil.
Cristina
C
Salles
D000293:Adolescent; D000402:Airway Obstruction / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000453:epidemiology*; D008297:Male; D009752:Nutritional Status; D010092:Oximetry; D017286:Polysomnography; D015995:Prevalence; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology*