Dopa-responsive dystonia in a ten-year-old girl.
Children with recent onset dystonia and gait abnormalities may pose a diagnostic challenge. A ten-year-old, developmentally normal girl, presented with a six-month history of gait abnormality and dystonia. Her complaint worsened as the day progressed. In view of typical diurnal variation of dystonia, a therapeutic challenge with levodopa/carbidopa was given and there was a dramatic response. Hence, a diagnosis of dopa-responsive dystonia (DRD) was made. DRD is an inherited disorder characterized by dystonia with diurnal variation and favorable response to levodopa/carbidopa. The inheritance is usually autosomal dominant, however, in some cases, autosomal-recessive inheritance is also seen.
Department of Pediatrics, AVMC and H, Kirumampakkam, Puducherry, India.
Venkatesh
V
Soma
Department of Pediatrics, AVMC and H, Kirumampakkam, Puducherry, India.
Hussain Sadiq
HS
Mohammed
Department of Pediatrics, AVMC and H, Kirumampakkam, Puducherry, India.
Ebrahim
E
Riyas
Department of Pediatrics, AVMC and H, Kirumampakkam, Puducherry, India.
Karuppasamy
K
Murugesan
Autosomal dominant dystonia with diurnal variation; Segawa's disease; dopa-responsive dystonia