Regulatory mechanisms of RNA function: emerging roles of DNA repair enzymes.
The acquisition of an appropriate set of chemical modifications is required in order to establish correct structure of RNA molecules, and essential for their function. Modification of RNA bases affects RNA maturation, RNA processing, RNA quality control, and protein translation. Some RNA modifications are directly involved in the regulation of these processes. RNA epigenetics is emerging as a mechanism to achieve dynamic regulation of RNA function. Other modifications may prevent or be a signal for degradation. All types of RNA species are subject to processing or degradation, and numerous cellular mechanisms are involved. Unexpectedly, several studies during the last decade have established a connection between DNA and RNA surveillance mechanisms in eukaryotes. Several proteins that respond to DNA damage, either to process or to signal the presence of damaged DNA, have been shown to participate in RNA quality control, turnover or processing. Some enzymes that repair DNA damage may also process modified RNA substrates. In this review, we give an overview of the DNA repair proteins that function in RNA metabolism. We also discuss the roles of two base excision repair enzymes, SMUG1 and APE1, in RNA quality control.
Division of Medicine, Department of Clinical Molecular Biology, Akershus University Hospital, Nordbyhagen, 1478, Lørenskog, Norway.
Laure
L
Jobert
Hilde
H
Nilsen
D004249:DNA Damage; D004260:DNA Repair / Q000235:genetics*; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D014176:Protein Biosynthesis; D012313:RNA / Q000737:chemistry*; D020871:RNA Stability / Q000235:genetics*; D051981:Uracil-DNA Glycosidase / Q000235:genetics / Q000378:metabolism
D012313:RNA; C498095:SMUG1 protein, human; D051981:Uracil-DNA Glycosidase; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase