Flavonoid and phenolic compounds from Salvia palaestina L. growing wild in Jordan and their antioxidant activities.
Investigation of the butanol fraction of Salvia palaestina Benth. from Jordanian origin resulted in the isolation and characterization of nine compounds, three of which are reported here for the first time in Nature. These compounds included the two phenolics: salpalaestinin (1), methyl 3-O-methylrosmarinate (3) and the flavonoid luteolin 7-O-(2″-p-hydroxybenzoyl)-β-glucuronide) (8). In addition, 3,4-dihydroxyphenyl caffeate (2), diosmetin (4), apigenin-7-O-(6″-butyryl-β-glucopyranoside) (5), luteolin-3'-O-methyl-7-O-(6″-butyryl-β-glucopyranoside) (6) and clinopodic acid B (7) were also obtained from the butanol fraction of the plant. The structures of the isolated compounds were elucidated by different spectroscopic methods including NMR (1D and 2D), UV, IR and MS (HRESIMS and EIMS). The DPPH radical scavenging activity for compounds 1, 3, 5, 6 &8 was evaluated. Compound 3 had the highest antioxidant activity (91.9±1.30% inhibition) with an IC₅₀ value of 1.0±0.23(μg/mL).
Department of Chemistry, Faculty of Science, Yarmouk University, Irbid, Jordan. Electronic address: mahmoud.qudah@yu.edu.jo.
Mahmoud A
MA
Al-Qudah
Department of Applied Sciences, Faculty of Engineering Technology, Al-Balqa Applied University, Marka, Jordan. Electronic address: rhhjaber@yahoo.com.
Hala I
HI
Al-Jaber
Department of Chemistry, Faculty of Science, The University of Jordan, Amman, Jordan.
Musa H
MH
Abu Zarga
Department of Chemistry, Faculty of Science, Yarmouk University, Irbid, Jordan.
Sultan T
ST
Abu Orabi
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007597:Jordan; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D027544:Salvia / Q000737:chemistry*; D013237:Stereoisomerism
D000975:Antioxidants; D001713:Biphenyl Compounds; D005419:Flavonoids; D016166:Free Radical Scavengers; D010636:Phenols; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl
Antioxidant activity; Luteolin 7-O-(2″-p-hydroxybenzoyl)-β-glucuronide; Methyl 3-O-methylrosmarinate; Salpalaestinin; Salvia palaestina