Immune-mediated mechanism for thrombocytopenia after Loxosceles spider bite.
Loxoscelism, characterized by high fever, vomiting, malaise, a dermonecrotic lesion, and thrombocytopenia, was diagnosed in a 3-year-old female. Clinical laboratory and dermatological signs are described. Blood test showed a transient hypercoagulable state and the presence of IgG antibodies against platelets, suggesting an immune-mediated mechanism for platelet destruction, in addition to the direct toxic effect of the spider venom. The finding of platelet antibodies after a Loxosceles spider bite has not been previously reported.
Pediatric Hematology Unit and Pediatric Department B, Emek Medical Center, Afula, Israel; The Ruth and Baruch Rappaport School of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Carina
C
Levin
Lilach
L
Bonstein
Roy
R
Lauterbach
Rivka
R
Mader
Dganit
D
Rozemman
Ariel
A
Koren
D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D063287:Brown Recluse Spider; D002675:Child, Preschool; D005260:Female; D006801:Humans; D001098:Spider Bites / Q000097:blood / Q000150:complications / Q000276:immunology; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology / Q000276:immunology
D001323:Autoantibodies
dermonecrosis; immune-mediated thrombocytopenia; loxoscelism; spider bite