The desmoplastic stroma of pancreatic cancer is a barrier to immune cell infiltration.
A detailed map demonstrating the spatially restricted distribution of immune cells within the desmoplastic stroma of human pancreatic tumors opens up the field of pancreatic oncoimmunology. CD8+T cells located in the proximity of malignant lesions are associated with a survival advantage, suggesting the existence of immunoediting. Pancreatic stellate cells appear to dictate the infiltration of the juxtatumoral stroma by CD8+T cells.
Centre for Tumour Biology; Barts Cancer Institute; Barts and the London School of Medicine and Dentistry; Queen Mary University of London; London, UK ; Barts and the London HPB Centre; The Royal London Hospital; Barts Health NHS Trust; London UK.
Jennifer
J
Watt
Centre for Tumour Biology; Barts Cancer Institute; Barts and the London School of Medicine and Dentistry; Queen Mary University of London; London, UK ; Barts and the London HPB Centre; The Royal London Hospital; Barts Health NHS Trust; London UK.
Hemant M
HM
Kocher
B cells; CD8+ T cells; macrophages; natural killer cells; neutrophils