Efficacy of dexamethasone on penicillin-induced epileptiform activity in rats: an electrophysiological study.
Corticosteroids are extensively used in treatment of many diseases. In neurosurgery practice, dexamethasone (DEX) is commonly used particularly in cerebral edema secondary to brain tumors, head trauma, and central nervous system infections. There are some uncertainties surrounding the secure use of DEX in patients with epilepsy or seizures induced by diseases of the central nervous system such as head trauma and brain tumors. Despite its extensive use, the effect of DEX on epileptiform activity is unclear. In this study the effect of DEX on epileptiform activity was investigated in rats. The effects of 1, 3, and 10mg/kg DEX on epileptiform activity was compared with effects of antiepileptic drugs commonly employed in treatment of epilepsy, namely phenytoin (PHT) 50mg/kg and levetiracetam (LEV) 50mg/kg that were administered intraperitoneally for 1 week. All groups were administered intracortical penicillin (500IU) to induce epileptiform activity. DEX at the doses of 3mg/kg and 10mg/kg significantly reduced spike frequencies compared to the initial values. In conclusion, we think that DEX can effectively decrease the epileptiform activity.
Department of Neurosurgery, Faculty of Medicine, Dicle University, Yenişehir 21280, Diyarbakir, Turkey. Electronic address: kartaltevfik@hotmail.com.
Tevfik
T
Yılmaz
Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Metehan
M
Akça
Department of Neurosurgery, Faculty of Medicine, Dicle University, Yenişehir 21280, Diyarbakir, Turkey.
Yahya
Y
Turan
Department of Anatomy, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Hakan
H
Ocak
Department of Neurosurgery, Faculty of Medicine, Dicle University, Yenişehir 21280, Diyarbakir, Turkey.
Kağan
K
Kamaşak
Department of Physiology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Mehmet
M
Yildirim
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology*; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology*; D005938:Glucocorticoids / Q000008:administration & dosage / Q000494:pharmacology; D000077287:Levetiracetam; D008297:Male; D010406:Penicillins; D010672:Phenytoin / Q000494:pharmacology; D010889:Piracetam / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D016896:Treatment Outcome
D000927:Anticonvulsants; D005938:Glucocorticoids; D010406:Penicillins; D000077287:Levetiracetam; D010672:Phenytoin; D003907:Dexamethasone; D010889:Piracetam
Dexamethasone; Experimental epilepsy; Levetiracetam; Penicillin; Phenytoin; Rat