Holmium laser enucleation of the prostate versus transurethral resection of the prostate: a randomized clinical trial.
OBJECTIVE
To evaluate the efficacy and safety of holmium laser enucleation of the prostate (HoLEP) and transurethral resection of the prostate (TURP), for treatment of benign prostatic hyperplasia (BPH).


METHODS
A total of 164 cases of BPH were selected from patients who were hospitalized between January 2010 and December 2011. Patients had received either HoLEP or TURP treatment. Clinical data were collected from the perioperative period, 1 month after surgery, and 12 months after surgery.


RESULTS
There was no significant difference between the two groups in the maximum urinary flow rate (Q max), postvoid residual volume (PVR), international prostate symptom score (IPSS), or quality-of-life score (QOL score) at 1 month after surgery (p = 0.56, p = 0.346, p = 0.536 and p = 0.145, respectively). However, after 12 months, patients from the HoLEP group demonstrated better scores in Qmax, PVR, IPSS, and QOL than those from the TURP group (p = 0.037, p = 0.003, p < 0.001 and p = 0.019, respectively). The two groups had comparable operation time (p = 0.105), catheterization time (p = 0.173), and length of hospital stay (p = 0.395), but were statistically different in the weight of resected prostate tissue (p < 0.001), bladder irrigation time (p < 0.001), hemoglobin levels (p = 0.011), and blood sodium levels (p = 0.002) after surgery.


CONCLUSIONS
Compared to TURP, HoLEP was safer and had better long-term efficacy as assessed by multiple quantitative measures. Therefore, HoLEP may present a better option in the treatment of BPH.
Department of Urology, Urology and Nephrology Center, First Hospital of Jilin University, No. 71 Xinmin Street, Changchun, 130021, Jilin, China, sy820925@163.com.
Nao
N
Sun
Yaowen
Y
Fu
Tengzheng
T
Tian
Jialin
J
Gao
Yuantao
Y
Wang
Song
S
Wang
Wei
W
An
D000368:Aged; D006801:Humans; D053844:Lasers, Solid-State; D008297:Male; D008875:Middle Aged; D061646:Operative Time; D011467:Prostate / Q000601:surgery*; D011470:Prostatic Hyperplasia / Q000601:surgery; D016896:Treatment Outcome; D014563:Urodynamics; D013521:Urologic Surgical Procedures, Male / Q000379:methods*