Bacterial growth: global effects on gene expression, growth feedback and proteome partition.
The function of endogenous as well as synthetic genetic circuits is generically coupled to the physiological state of the cell. For exponentially growing bacteria, a key characteristic of the state of the cell is the growth rate and thus gene expression is often growth-rate dependent. Here we review recent results on growth-rate dependent gene expression. We distinguish different types of growth-rate dependencies by the mechanisms of regulation involved and the presence or absence of an effect of the gene product on growth. The latter can lead to growth feedback, feedback mediated by changes of the global state of the cell. Moreover, we discuss how growth rate dependence can be used as a guide to study the molecular implementation of physiological regulation.
Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany. Electronic address: klumpp@mpikg.mpg.de.
Stefan
S
Klumpp
Department of Physics, University of California at San Diego, La Jolla, CA 92093-0374, United States; Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, CA 92093-0374, United States; Section of Molecular Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, CA 92093-0374, United States.
Terence
T
Hwa
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000235:genetics* / Q000254:growth & development* / Q000378:metabolism; D024881:Drug Resistance, Bacterial / Q000235:genetics; D025461:Feedback, Physiological; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D020543:Proteome / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D020543:Proteome