A new diterpene from Clinopodium chinense.
A new abietane diterpene, named as 3β-hydroxy-12-O-β-D-glucopyranosyl-8,11,13-abietatrien-7-one (1), together with four known flavonoids, was isolated from the hot water extract of the aerial parts of Clinopodium chinense. Their structures were determined by analysing the spectroscopic data including 1D, 2D NMR and HR-ESI-MS. Compound 1 tested against HepG-2 and A549 cancer cell lines expressed weak cytotoxicity. Cardioprotective effects of compounds 2-5 against H2O2-induced apoptosis in H9c2 cells were also evaluated; compounds 2 and 3 exhibited moderate cardioprotective effect.
a Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine , Peking Union Medical College, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences , Beijing 100193 , P.R. China.
Mingliang
M
Zhong
Haifeng
H
Wu
Xiaopo
X
Zhang
Guangli
G
Sun
Guibo
G
Sun
Shichun
S
Yu
Xudong
X
Xu
D045784:Abietanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D045784:Abietanes; D000972:Antineoplastic Agents, Phytogenic; D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D005960:Glucosides; D006861:Hydrogen Peroxide