Nakijiquinone S and nakijinol C, new meroterpenoids from a marine sponge of the family spongiidae.
New meroterpenoids, nakijiquinone S (1) and nakijinol C (2), have been isolated from an Okinawan marine sponge of the family Spongiidae. The gross structures and relative stereochemistries of 1 and 2 were elucidated on the basis of their spectral data. Nakijiquinone S (1) and nakijinol C (2) were new meroterpenoids consisting of a clerodane-type decalin ring connected to a 2-butoxy-5-hydroxy-benzoquinone unit or methyl 2,3,4-trihydroxybenzoate unit through a methylene, respectively. Nakijiquinone S (1) and nakijinol C (2) showed antimicrobial activities against several bacteria and fungi.
Graduate School of Pharmaceutical Sciences, Hokkaido University.
Haruna
H
Suzuki
Takaaki
T
Kubota
Azusa
A
Takahashi-Nakaguchi
Jane
J
Fromont
Tohru
T
Gonoi
Jun'ichi
J
Kobayashi
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D016227:Benzoquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008958:Models, Molecular; D009181:Mycoses / Q000188:drug therapy; D011161:Porifera / Q000737:chemistry*; D011748:Pyrogallol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D000890:Anti-Infective Agents; D016227:Benzoquinones; D012717:Sesquiterpenes; C000591905:nakijinol C; C000591904:nakijiquinone S; D011748:Pyrogallol