Newly diagnosed dementia and increased risk of hemorrhagic stroke: A nationwide population-based study.
BACKGROUND
This retrospective cohort study was designed to assess whether there is an association between newly diagnosed dementia and the risk of stroke.


METHODS
From Taiwan's National Health Insurance Research Database of reimbursement claims, we identified 2811 patients with newly diagnosed dementia and 14,055 randomly selected, age-matched patients without dementia. A Cox proportional hazards model was constructed to calculate the development of stroke, including ischemic stroke, and intracerebral, or subarachnoid hemorrhage.


RESULTS
During the 3-year follow-up period, 339 patients with dementia (12.06%) and 691 patients without dementia (4.92%) developed stroke. The adjusted HRs of developing stroke among newly diagnosed dementia patients were 2.33-times (range, 2.05-2.66), and the incidence of hemorrhagic stroke was higher than that of other stroke types. Patients who had Alzheimer's disease were at the highest risk of hemorrhagic stroke.


CONCLUSIONS
Individuals with dementia, especially Alzheimer's disease, are at greater risk of developing stroke, especially in intracerebral and subarachnoid hemorrhage than patients without dementia. Early mental screening programs and health education should be initiated for dementia patients.
Hao-Kuang
HK
Wang
Kuen-Jer
KJ
Tsai
Chih-Yuan
CY
Huang
Liang-Chao
LC
Wang
Kang
K
Lu
Han-Jung
HJ
Chen
Chi-Wei
CW
Lin
Yi-Jer
YJ
Lee
Pei-Hsuan
PH
Fang
Li-Ching
LC
Chang
Institute of Health Care Management, National Sun Yat-Sen University, Kaohsiung, Taiwan. ycli@faculty.nsysu.edu.tw.
Ying-Chun
YC
Li
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D018672:Community Health Planning; D016208:Databases, Factual / Q000706:statistics & numerical data; D003704:Dementia / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006470:Hemorrhage / Q000150:complications*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009313:National Health Programs / Q000706:statistics & numerical data; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology*; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult