Oxford-MEST classification in IgA nephropathy patients: A report from Iran.
BACKGROUND
There is a limited knowledge about the morphological features of IgA nephropathy (IgAN)in the middle east region.


OBJECTIVE
The objective of this study was to evaluate the spectrum of histopathological findings in IgAN patients at our laboratory.


METHODS
At this work, an observational study reported which was conducted on IgAN patients using the Oxford-MEST classification system.


RESULTS
In this survey, of 102 patients 71.6 % were male. The mean age of the patients was 37.7 ± 13.6 years. Morphologic variables of MEST classification was as follows; M1: 90.2 %, E: 32 %, S: 67 % also,T in grads I and II were in 30% and 19% respectively, while 51% were in grade zero. A significant difference was observed in segmental glomerulosclerosis (P=0.003) and interstitial fibrosis/tubular atrophy frequency distribution (P= 0.045), between males and females . Furthermore, it was found that mesangial hypercellularity was more prevalent in yonger patients. Moreover, there was a significant correlation between serum creatinine and crescents (P<0.001). There was also significant correlation of serum creatinine with segmental glomerulosclerosis (P<0.001).


CONCLUSIONS
Higher prevalence of segmental glomerulosclerosis and interstitial fibrosis/ tubular atrophy, as the two of, four variables of Oxford-MEST classification of IgAN in male patients further attests that male gender is a risk factor in this disease.In this study the significant correlation between serum creatinine and crescent was in an agreement with previous studies and suggests for the probable accomodation of extracapillary proliferation as a new variable in MEST system.
Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan,Iran.
Hamid
H
Nasri
Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan , Iran.
Mojgan
M
Mortazavi
Department of Nephrology, Ahvaz Jundishpur University of Medical Sciences, Ahvaz, Iran.
Ali
A
Ghorbani
Department of Nephrology, Ahvaz Jundishpur University of Medical Sciences, Ahvaz, Iran.
Heshmatollah
H
Shahbazian
Department of Biostatistics and Epidemiology, Faculty of Health,Shahrekord University of Medical Sciences, Shahrekord, Iran.
Soleiman
S
Kheiri
Department of Pathology, Isfahan University of Medical Sciences, Isfahan , Iran.
Azar
A
Baradaran
Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan , Iran.
Afsoon
A
Emami-Naieni
Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan,Iran.
Maryam
M
Saffari
Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Saeed
S
Mardani
Department of Nephrology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Ali
A
Momeni
Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan , Iran.
Yahya
Y
Madihi
Medical Physics and Medical Engineering Department,Isfahan University of Medical Sciences ,Isfahan, Iran.
Milad
M
Baradaran-Ghahfarokhi
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Mahmoud
M
Rafieian-Kopaie
Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan , Iran.
Parin
P
Hedayati
Division of Renal Immunopathology, Dr. Baradaran Laboratory, Isfahan, Iran.
Shahzad
S
Baradaran
Department of Nephrology, Tabriz University of Medical Sciences, Tabriz , Iran.
Mohammadreza
M
Ardalan
Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan , Iran.
Shahram
S
Sajjadieh
Cardiovascular and Renal Research Laboratory, Memorial University of New found land, Canada.
Naziheh
N
Assarzadegan
Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Seyed Mohammad
SM
Ahmadi Soleimani
Department of Nephrology, Semnan University of Medical Sciences, Semnan, Iran.
Mohamad Reza
MR
Tamadon
Classification; Glomerulosclerosis; IgA nephropathy; Interstitial fibrosis; Proliferation; Tubular atrophy