Increased efficiency in geographic ancestry assignment and human identification by combining lineage profiles: The case of the Iranians.
OBJECTIVE
This research is a first empirical attempt to quantify the increase of the among-groups variance and the probative value of a DNA evidence when combining profiles based on markers with uniparental inheritance.


METHODS
Yfiler and HVS-I panels of loci were analyzed in 130 healthy unrelated males from six Iranian native groups.


RESULTS
A separate analysis of DNA profiles at the two lineage markers failed to detect a population substructure, whereas maximum levels of genetic diversity (HD = 1) and discrimination capacity (DC = 1) were obtained by combining the two profiles.


CONCLUSIONS
When combined, the forensic efficiency of routinely used panels of lineage markers can be largely sufficient to resolve cases of geographic ancestry and human identification even in genetically homogeneous populations.
Dipartimento di Biologia, Università di Pisa, Pisa, Italy.
Sergio
S
Tofanelli
Stefania
S
Bertoncini
Shirin
S
Farjadian
Abbas
A
Ghaderi
Gianmarco
G
Ferri
Giovanni
G
Romeo
Donata
D
Luiselli
D041322:Chromosomes, Human, Y / Q000235:genetics*; D018732:Forensic Anthropology / Q000379:methods*; D005787:Gene Frequency; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D007492:Iran; D008297:Male; D010375:Pedigree; D016133:Polymerase Chain Reaction