Orbital nerve seath myxoma with extraocular muscle involvement: a rare case.
A 66-year-old woman with breast cancer presented with a painless mass in the left orbit. MRI revealed a well-defined intraconal mass in the temporal quadrant of the orbit. Fifteen months later, a further MRI indicated the mass had grown, displacing the left optic nerve and making contact with the lateral rectus muscle, suggesting its possible intramuscular origin. Despite the clinical and radiological characteristics of the lesion and its slow growth, a PET/CT study was developed because of the history of malignant disease. No metabolic activity of the mass or malignant lesion in other locations was observed. After surgical excision, histopathological examination revealed an abundant myxoid matrix with few spindle-shaped cells and no signs of malignancy. The cells were immunopositive for CD34, positive for S-100 protein, and negative for EMA, actin, and CD57. A diagnosis was made of a nerve sheath myxoma. The orbital location of these tumors is extremely rare.
Department of Ophthalmology, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC) , Madrid , Spain .
Ignacio
I
Rodríguez-Uña
Juan A
JA
Troyano-Rivas
Cristina
C
González-García
Reinaldo
R
Chícharo-de-Freitas
Juan J
JJ
Ortiz-Zapata
Luis
L
Ortega-Medina
Nicolás
N
Toledano-Fernández
Julián
J
García-Feijoo
D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D009363:Neoplasm Proteins / Q000378:metabolism; D018321:Neurothekeoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D009801:Oculomotor Muscles / Q000294:innervation*; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D049268:Positron-Emission Tomography; D009418:S100 Proteins / Q000378:metabolism; D014057:Tomography, X-Ray Computed
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D009418:S100 Proteins; D019788:Fluorodeoxyglucose F18
Benign tumors; immunohistochemistry; nerve sheath myxoma; neurothekeoma; orbital neoplasms