Association of angiopoietin-2 and dimethylarginines with complicated course in patients with leptospirosis.
Leptospirosis is one of the most relevant zoonosis worldwide and a potentially life-threatening infectious disease. While it is frequent in tropic regions, it is uncommon in European industrialized countries. Angiopoietin-2 (Angpt-2) and asymmetric and symmetric dimethylarginine (ADMA and SDMA) are markers of endothelial activation and systemic inflammation. These parameters have been studied recently in the context of sepsis and MODS showing potential to determine disease severity and outcome specific parameters like acute kidney injury (AKI) and survival. These biomarkers were measured in 13 patients with leptospirosis. High levels of Angpt-2 were statistically significant associated with a complicated clinical course with occurrence of AKI, Sepsis and intensive care unit treatment. ADMA was significantly associated with occurrence of AKI and ICU treatment whereas SDMA was associated with AKI. Therefore these endothelial markers may serve as additional tools for risk stratification in these patients.
Department of Nephrology & Hypertension, Hannover Medical School, Hannover, Germany ; Department of Medicine D, Division of General Internal Medicine, Nephrology, and Rheumatology, University Hospital Muenster, Muenster, Germany.
Alexander
A
Lukasz
Department of Infectious Diseases and Pulmonology, Charité University Medicine, Berlin, Germany.
Bodo
B
Hoffmeister
Department of Microbiology and Hygiene, Charité University Medicine, Berlin, Germany.
Barbara
B
Graf
Institute for Virology, Hannover Medical School, Hannover, Germany.
Benno
B
Wölk
Bundesinstitut für Risikobewertung, Abteilung für Biologische Sicherheit, Berlin, Germany.
Karsten
K
Noeckler
Institute for Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany.
Stefanie M
SM
Bode-Böger
Department of Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany.
Johannes
J
Hadem
Department of Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany.
Sven
S
Pischke
Department of Nephrology & Hypertension, Hannover Medical School, Hannover, Germany.
Jan T
JT
Kielstein
D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D000328:Adult; D042702:Angiopoietin-2 / Q000378:metabolism*; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000378:metabolism / Q000473:pathology; D007362:Intensive Care Units; D007922:Leptospirosis / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D012720:Severity of Illness Index
D042702:Angiopoietin-2; D015415:Biomarkers; C487735:dimethylarginine; D001120:Arginine