Polycystic ovary syndrome and low-grade inflammation with special reference to YKL-40.
OBJECTIVE
To evaluate the plasma level of YKL-40 in a Danish polycystic ovary syndrome (PCOS) population and to investigate whether YKL-40 is associated with CVD risk factors such as waist circumference, body mass index (BMI), insulin resistance (IR), fasting glucose, fasting insulin, blood lipids and CRP.


METHODS
Cross-sectional study.


METHODS
Gynecological clinics at three Danish University Hospitals.


METHODS
One hundred seventy-one premenopausal women with PCOS recruited consecutively from April 2010 to February 2012. PCOS was diagnosed according to the Rotterdam criteria.


METHODS
Plasma level of YKL-40 in four phenotypes of PCOS defined by BMI and IR.


RESULTS
No statistically significant difference was observed in the plasma level of YKL-40 across the four BMI/IR-phenotypes. Positive associations were observed between YKL-40 and BMI, total and free testosterone, triglycerides, and CRP. Total and free testosterone were independent predictors of YKL-40.


CONCLUSIONS
YKL-40, the marker of low-grade inflammation is not increased in women with PCOS.
Department of Gynaecology and Obstetrics, Faculty of Health and Medical Sciences, Herlev Hospital, Copenhagen University , Herlev , Denmark .
M
M
Aziz
M L M
ML
Wissing
K V
KV
Naver
J
J
Faber
S O
SO
Skouby
D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D000071451:Chitinase-3-Like Protein 1; D003430:Cross-Sectional Studies; D003718:Denmark; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D037102:Lectins / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D011446:Prospective Studies; D012044:Regression Analysis; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D007328:Insulin; D037102:Lectins; D014280:Triglycerides; D002097:C-Reactive Protein