Angiotensin-converting enzyme I/D polymorphism is associated with pneumonia risk: a meta-analysis.
BACKGROUND
Previous studies examined the association between angiotensin-converting enzyme (ACE) I/D polymorphism and pneumonia, but their results were inconsistent. Thus, a meta-analysis was performed to clarify the effect of ACE I/D polymorphism on pneumonia risk and pneumonia-related mortality.


METHODS
The PubMed, Embase, and Chinese National Knowledge Infrastructure (CNKI) databases were searched for relevant studies published up to 27 April 2013. Data were extracted and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.


RESULTS
Pooled analysis of 12 case-control studies (1431 cases and 3600 controls) showed that there was a significant association between ACE I/D polymorphism and pneumonia risk in a recessive genetic model (OR = 1.53, 95% CI 1.30-1.80, p < 0.00001). No significant association between ACE I/D polymorphism and mortality was observed (OR = 2.68, 95% CI 0.80-8.90, p = 0.11).


CONCLUSIONS
Our meta-analysis confirmed that ACE I/D polymorphism was associated with pneumonia risk. However, ACE I/D polymorphism was not associated with pneumonia mortality.
Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Wei
W
Nie
Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Yuansheng
Y
Zang
Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Jiquan
J
Chen
Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Tao
T
Liu
Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China.
Lin
L
Xiao
Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China xiu_qingyu@126.com.
Qingyu
Q
Xiu
D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011014:Pneumonia / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors
D007703:Peptidyl-Dipeptidase A
Angiotensin-converting enzyme; association study; mortality; pneumonia; polymorphism