Hot-melt co-extrusion for the production of fixed-dose combination products with a controlled release ethylcellulose matrix core.
In this study, hot-melt co-extrusion was evaluated as a technique for the production of fixed-dose combination products, using ethylcellulose as a core matrix former to control the release of metoprolol tartrate and a polyethylene oxide-based coat formulation to obtain immediate release of hydrochlorothiazide. By lowering the concentration of the hydrophilic additive polyethylene oxide in the plasticized ethylcellulose matrix or by lowering the drug load, the in vitro metoprolol tartrate release from the core was substantially sustained. The in vitro release of hydrochlorothiazide from the polyethylene oxide/polyethylene glycol coat was completed within 45 min for all formulations. Tensile testing of the core/coat mini-matrices revealed an adequate adhesion between the two layers. Raman mapping showed no migration of active substances. Solid state characterization indicated that the crystalline state of metoprolol tartrate was not affected by thermal processing via hot-melt extrusion, while hydrochlorothiazide was amorphous in the coat. These solid state characteristics were confirmed during the stability study. Considering the bioavailability of metoprolol tartrate after oral administration to dogs, the different co-extruded formulations offered a range of sustained release characteristics. Moreover, high metoprolol tartrate plasma concentrations were reached in dogs allowing the administered dose to be halved.
Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
A-K
AK
Vynckier
Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
L
L
Dierickx
Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Ghent, Belgium.
L
L
Saerens
CONEXUS Pharma, Ghent, Belgium.
J
J
Voorspoels
CONEXUS Pharma, Ghent, Belgium.
Y
Y
Gonnissen
Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Ghent, Belgium.
T
T
De Beer
Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium. Electronic address: Chris.Vervaet@UGent.be.
C
C
Vervaet
Laboratory of Pharmaceutical Technology, Ghent University, Ghent, Belgium.
J P
JP
Remon
D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D004285:Dogs; D004338:Drug Combinations; D006358:Hot Temperature; D008297:Male
D003692:Delayed-Action Preparations; D004338:Drug Combinations; C013517:ethyl cellulose; D002482:Cellulose
Co-extrusion; Fixed-dose combination product; Hot-melt extrusion; Hydrochlorothiazide (PubChem CID: 3639); Immediate release; Matrix; Metoprolol tartrate (PubChem CID: 441308); Sustained release