Radical cyclization/ipso-1,4-aryl migration cascade: asymmetric synthesis of 3,3-difluoro-2-propanoylbicyclo[3.3.0]octanes.
A novel method for the asymmetric synthesis of 3,3-difluoro-2-propanoylbicyclo-[3.3.0]octanes involves an unprecedented intramolecular radical cyclization/ipso-1,4-aryl migration cascade.
Center of Excellence for Innovation in Chemistry (PERCH-CIC) and Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400 (Thailand).
Watcharaporn
W
Thaharn
Darunee
D
Soorukram
Chutima
C
Kuhakarn
Patoomratana
P
Tuchinda
Vichai
V
Reutrakul
Manat
M
Pohmakotr
cyclization; fluorine; radical reactions; reaction mechanism; synthetic methods