Nicotine exposure, blood pressure, and inflammation in tobacco smokers and chewers in a rural community in Nepal.
Tobacco consumption is high amongst the people of Xxx. This study was carried out in 2011 in a rural community of Xxx, to compare pathological parameters associated with tobacco use in relation to nicotine metabolism between smokers, chewers, and a control group. A total of 216 volunteers provided blood and urine samples for testing nicotine metabolites, C-reactive protein, and cell counts. Data were analyzed using ANOVA, correlation, and t-tests using STATA. Differences in blood pressure amongst the groups indicate a role of smoking in preventing a rise in BP with age, likely attributable to a different mechanism of metabolism of tobacco constituents.
Department of Biochemistry, Xxx Medical College Basic Sciences Block, Xxx, Xxx, Xxx.
Arti S
AS
Pandey
Naveen K
NK
Shreevastva
Durga P
DP
Neupane
D000328:Adult; D000368:Aged; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000276:immunology*; D016022:Case-Control Studies; D003367:Cotinine / Q000652:urine*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009390:Nepal; D009538:Nicotine / Q000378:metabolism*; D012424:Rural Population; D012907:Smoking / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D064424:Tobacco Use / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D055815:Young Adult
D009538:Nicotine; D002097:C-Reactive Protein; D003367:Cotinine