Bronchial hyperreactivity in children with antibody deficiencies.
BACKGROUND
Antibody deficiency comprises a heterogeneous group of disorders characterised by the body's inability to mount an effective antibody response to pathogens. Although it has been reported that asthma and allergic disease are frequent in antibody deficiencies, there are no data that evaluate and compare bronchial hyperreactivity (BHR) in all groups of antibody deficiencies. In this study, we aimed to evaluate and compare the frequency of BHR in patients with different antibody deficiencies.


METHODS
The study was carried out on 113 patients between ages 5 and 18 diagnosed with antibody deficiencies. The patients and their families were questioned on their history of asthma and allergic diseases. Allergic skin prick tests and non-specific bronchial provocation test with methacholine was done for all patients. Complete blood count and serum total IgE levels were measured.


RESULTS
The mean age of the patients was 10.8 ± 3.8 years and 66.4% were male. Within the study group 41.6% of the patients had selective IgA deficiency, 24.8% had IgG subclass deficiency, 14.2% had partial IgA deficiency, 10.6% had common variable immunodeficiency, 6.2% had transient hypogammaglobulinaemia and 2.7% X-linked agammaglobulinaemia. In total group, 42.5% had bronchial hyperreactivity with methacholine challenge test. BHR was more significant in both patients with selective IgA deficiency and partial IgA deficiency compared to those with IgG subclass deficiency (P=0.041 and P=0.038, respectively).


CONCLUSIONS
BHR was high in antibody deficiencies, especially selective IgA deficiency compared to IgG subclass deficiency.
Ankara Children's Hematology Oncology, Education and Research Hospital, Department of Pediatric Allergy and Immunology, Ankara, Turkey. Electronic address: celalozcan01@yahoo.com.tr.
Celal
C
Özcan
Ankara Children's Hematology Oncology, Education and Research Hospital, Department of Pediatric Allergy and Immunology, Ankara, Turkey.
Ayşe
A
Metin
Ankara Children's Hematology Oncology, Education and Research Hospital, Department of Pediatric Allergy and Immunology, Ankara, Turkey.
Mustafa
M
Erkoçoğlu
Ankara Children's Hematology Oncology, Education and Research Hospital, Department of Pediatric Allergy and Immunology, Ankara, Turkey.
Can Naci
CN
Kocabas
D000293:Adolescent; D000485:Allergens / Q000276:immunology; D000906:Antibodies / Q000235:genetics*; D001772:Blood Cell Count; D016535:Bronchial Hyperreactivity / Q000453:epidemiology*; D001985:Bronchial Provocation Tests; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D017098:IgA Deficiency / Q000453:epidemiology*; D007073:Immunoglobulin E / Q000097:blood; D007153:Immunologic Deficiency Syndromes / Q000453:epidemiology*; D015994:Incidence; D008297:Male; D012882:Skin Tests
D000485:Allergens; D000906:Antibodies; D007073:Immunoglobulin E
Allergy; Antibody deficiency; Bronchial hyperreactivity; IgA deficiency; IgG subclass deficiency