Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia.
Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
K
K
Matsuda
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
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000000030793815X
Y
Nakazawa
Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
C
C
Iwashita
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
T
T
Kurata
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
K
K
Hirabayashi
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
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S
Saito
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
M
M
Tanaka
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
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K
Yoshikawa
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
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R
Yanagisawa
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
K
K
Sakashita
Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki, Japan.
S
S
Sasaki
Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan.
T
T
Honda
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.
K
K
Koike
D002675:Child, Preschool; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007223:Infant; D054429:Leukemia, Myelomonocytic, Juvenile / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D008297:Male; D015122:Mercaptopurine / Q000494:pharmacology* / Q000627:therapeutic use*; D009154:Mutation; D014411:Neoplastic Stem Cells / Q000187:drug effects* / Q000378:metabolism*; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics*; D015398:Signal Transduction; D016896:Treatment Outcome
D015122:Mercaptopurine; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11