The immune contexture of primary and metastatic human tumours.
A tumour grows in a complex microenvironment composed of stromal cells, lymphoid and myeloid cells, vascular and lymphatic vessels, and the resultant cytokine and chemokine milieu. In most primary tumours, a strong Th1/cytotoxic T cells infiltration correlates with a longer survival. This beneficial effect can be hampered by the presence of M2 polarized macrophages and high VEGF production. Recent studies revealed that the pattern of the tumour microenvironment remains a major prognostic factor even in the metastatic lesions, while been reproducible between the primary and metastatic tumour. Nevertheless the prognostic impact of the Th1/cytotoxic T cell infiltrate could be different according to the origin of the primary tumour. This model highlights a novel tumour cell-dependent immune contexture that predicts patient's clinical outcome and has implications in the use of immunotherapies.
INSERM UMRS872, Cordeliers Research Center, Immune Microenvironment and Tumours Laboratory, Paris, France; Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France.
Nicolas A
NA
Giraldo
INSERM UMRS872, Cordeliers Research Center, Immune Microenvironment and Tumours Laboratory, Paris, France; Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France.
Etienne
E
Becht
INSERM UMRS872, Cordeliers Research Center, Immune Microenvironment and Tumours Laboratory, Paris, France; Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France.
Romain
R
Remark
INSERM UMRS872, Cordeliers Research Center, Immune Microenvironment and Tumours Laboratory, Paris, France; Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France; Department of Pathology, Hôpital Cochin, Paris, France.
Diane
D
Damotte
INSERM UMRS872, Cordeliers Research Center, Immune Microenvironment and Tumours Laboratory, Paris, France; Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France.
Catherine
C
Sautès-Fridman
INSERM UMRS872, Cordeliers Research Center, Immune Microenvironment and Tumours Laboratory, Paris, France; Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France. Electronic address: herve.fridman@crc.jussieu.fr.
Wolf H
WH
Fridman
D006801:Humans; D007249:Inflammation / Q000276:immunology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D059016:Tumor Microenvironment