The extended reductive acetyl-CoA pathway: ATPases in metal cluster maturation and reductive activation.
The reductive acetyl-coenzyme A (acetyl-CoA) pathway, also known as the Wood-Ljungdahl pathway, allows reduction and condensation of two molecules of carbon dioxide (CO2) to build the acetyl-group of acetyl-CoA. Productive utilization of CO2 relies on a set of oxygen sensitive metalloenzymes exploiting the metal organic chemistry of nickel and cobalt to synthesize acetyl-CoA from activated one-carbon compounds. In addition to the central catalysts, CO dehydrogenase and acetyl-CoA synthase, ATPases are needed in the pathway. This allows the coupling of ATP binding and hydrolysis to electron transfer against a redox potential gradient and metal incorporation to (re)activate one of the central players of the pathway. This review gives an overview about our current knowledge on how these ATPases achieve their tasks of maturation and reductive activation.
Jae-Hun
JH
Jeoung
Sebastian
S
Goetzl
Sandra Elisabeth
SE
Hennig
Jochen
J
Fesseler
Christina
C
Wörmann
Julia
J
Dendra
Holger
H
Dobbek
D000105:Acetyl Coenzyme A / Q000378:metabolism*; D002245:Carbon Dioxide; D002248:Carbon Monoxide; D002384:Catalysis; D008670:Metals; D009532:Nickel
D008670:Metals; D002245:Carbon Dioxide; D000105:Acetyl Coenzyme A; D009532:Nickel; D002248:Carbon Monoxide