Rapid and specific determination of DNA adducts for clinical diagnosis of poisoning and disease associated with aristolochic acid.
1. A liquid chromatography-mass spectrometry method was developed to detect and characterise aristocholic acid-DNA adducts in biological samples. 2. The detection of DNA adducts in plasma, urine or the cells found in urine may be useful to support the diagnosis and monitoring of aristocholic acid-associated poisoning and disease. 3. Efforts should be made to improve the sensitivity and specificity of this approach for the detection and characterisation of exposure to other mutagens/carcinogens.
Department of Chemistry, Hong Kong Baptist University.
Z W
ZW
Cai
A Y W
AY
Chan
Z Z
ZZ
Zhao
D034341:Aristolochic Acids / Q000506:poisoning*; D015415:Biomarkers / Q000032:analysis; D002853:Chromatography, Liquid; D018736:DNA Adducts / Q000032:analysis*; D006801:Humans; D066298:In Vitro Techniques; D013058:Mass Spectrometry; D012680:Sensitivity and Specificity
D034341:Aristolochic Acids; D015415:Biomarkers; D018736:DNA Adducts; C000228:aristolochic acid I