Evaluation of risk of atherosclerosis in Indian adults.
OBJECTIVE
To investigate interrelationship of arterial measurements with metabolic syndrome (MS) components and zinc status in apparently healthy Indian adults.


METHODS
Anthropometry and biochemical data were recorded in 110 men and 139 women (25-50 yr). Carotid Intima media thickness (CIMT), stiffness (beta), pulse wave velocity (PWV), elasticity modulus (Ep), and arterial compliance (AC) of the right carotid artery were evaluated ultrasonically. According to definition of MS, subjects were categorized as MS-1, MS-2, MS-3. Further, normal and MS subjects were divided as zinc sufficient and deficient.


RESULTS
In all, 12.1% subjects had 3 risk factors for MS. Mean CIMT, beta, Ep and PWV were significantly higher by 6%, 11.6%, 29.5% and 12.4% in subjects with MS than normal (p < 0.05). AC showed significant decline in MS subjects by only 3% than normal (p < 0.05). Serum zinc was inversely correlated with beta, Ep and PWV in both the genders in subjects with MS (p < 0.05). A synergistic effect of serum zinc deficiency with MS further envisages the elevated risk of arterial stiffness.


CONCLUSIONS
Risk of atherosclerosis is marked by increase in stiffness parameters even in presence of a single MS risk and zinc deficiency may further aggravate the risk indicating need for early diagnosis.
Agharkar Research Institute, Agarakar Road, Pune 411 004, India.
Deepa
D
Pandit
Hirabai Cowasji Jehangir Medical Research Institute, 32, Sassoon Road, Pune 411 001, India.
Shashi
S
Chiplonkar
Hirabai Cowasji Jehangir Medical Research Institute, 32, Sassoon Road, Pune 411 001, India.
Anuradha
A
Khadilkar
Hirabai Cowasji Jehangir Medical Research Institute, 32, Sassoon Road, Pune 411 001, India.
Arun
A
Kinare
Hirabai Cowasji Jehangir Medical Research Institute, 32, Sassoon Road, Pune 411 001, India.
Vaman
V
Khadilkar
Hirabai Cowasji Jehangir Medical Research Institute, 32, Sassoon Road, Pune 411 001, India.
Uma
U
Divate
D000328:Adult; D050197:Atherosclerosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D002339:Carotid Arteries / Q000473:pathology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D008875:Middle Aged; D012307:Risk Factors; D059289:Vascular Stiffness / Q000502:physiology; D015032:Zinc / Q000172:deficiency*
D015032:Zinc