[Physiological significance of nongenomic mechanisms of glucocorticoids].
Glucocorticoids (GC) are the most important regulatory hormones involved in stress response. GCs are also widely used clinically as anti-inflammatory and immunosuppressive drugs. In addition to the well-known classical genomic mechanisms, GCs also take effects by nongenomic mechanisms. The therapeutic benefits of nongenomic GC actions have been exploited in clinical medicine, especially with high-dose pulsed glucocorticoid administration. However, it is certainly not the case that the inherent non-genomic glucocorticoid mechanisms evolved only for their clinical utility. So that there must exist some unrevealed important physiological significance. Based onour series of studies focusing on the active actions of the rapid secreted GC over the last few years and literature review, we propose that the physiological significance of nongenomic mechanisms of GC lies in stress regulation.
Laboratory of Stress Medicine, Faculty of Psychology and Mental Health, Shanghai, China.
Lei
L
Liu
Laboratory of Stress Medicine, Faculty of Psychology and Mental Health, Shanghai, China.
Ting
T
Zhang
Laboratory of Stress Medicine, Faculty of Psychology and Mental Health, Shanghai, China.
Chun-Lie
CL
Jiang
D000818:Animals; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents; D013312:Stress, Physiological
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D007166:Immunosuppressive Agents