Breaking news on the enantioselective intermolecular Heck reaction.
Glowing results with less phosphorus: Tremendous progress has been made recently in asymmetric intermolecular Heck chemistry. Previously unprecedented enantioselective Heck-Matsuda reactions have been accomplished, and mixed phosphine/phosphine oxides have been shown to be superior ligands in enantioselective Mizoroki-Heck reactions. All of this was achieved with chiral ligands containing few or even no phosphorus donors (see scheme).
Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623 Berlin (Germany) http://www.organometallics.tu-berlin.de. martin.oestreich@tu-berlin.de.
Martin
M
Oestreich
D000438:Alcohols / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic
D000438:Alcohols; D000475:Alkenes
Heck-Matsuda reaction; Mizoroki-Heck reaction; asymmetric catalysis; hemilabile ligands