The effect of hyperinsulinemia and hyperglycemia on endothelial function in pregnant patients with type-2 diabetes.
We studied endothelial function (flow mediated vasodilation, FMD) during hyperinsulinemia and hyperglycemia in pregnant women with type-2 diabetes, in the second and third trimester. We found that hyperglycemia reduces FMD in late pregnancy.
The Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Reena
R
Khurana
The Division of Geriatric Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address: meneilly@mail.ubc.ca.
Graydon S
GS
Meneilly
The Division of Perinatology, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
Kenneth
K
Lim
The Division of Endocrinology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
David
D
Thompson
D000328:Adult; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000503:physiopathology*; D006946:Hyperinsulinism / Q000150:complications / Q000503:physiopathology*; D008297:Male; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D014664:Vasodilation
Endothelial function; Glucose clamp; Pregnancy; Type-2 diabetes