C-Terminal acetylene derivatized peptides via silyl-based alkyne immobilization.
A new Silyl-based Alkyne Modifying (SAM)-linker for the synthesis of C-terminal acetylene-derivatized peptides is reported. The broad scope of this SAM2-linker is illustrated by manual synthesis of peptides that are side-chain protected, fully deprotected, and disulfide-bridged. Synthesis of a 14-meric (KLAKLAK)2 derivative by microwave-assisted automated SPPS and a one-pot cleavage click procedure yielding protected 1,2,3-triazole peptide conjugates are also described.
Inorganic Chemistry I, Bioinorganic Chemistry, Faculty of Chemistry and Biochemistry, Ruhr-Universität Bochum , Universitätsstrasse 150, 44801 Bochum, Germany.
Martin
M
Strack
Nils
N
Metzler-Nolte
H Bauke
HB
Albada
D000114:Acetylene / Q000138:chemical synthesis / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D000595:Amino Acid Sequence; D055767:Immobilized Proteins / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012821:Silanes / Q000737:chemistry*
D000480:Alkynes; D055767:Immobilized Proteins; D010455:Peptides; D012821:Silanes; D000114:Acetylene