Detection of heterozygous c.1708C>T and c.1978C>G thyroid peroxidase (TPO) mutations in Iraqi patients with toxic and nontoxic goiter.
Sixty-three Arabic patients (16 males and 47 females) with thyroid toxic and nontoxic goiter who attended the endocrinologist in Nuclear Medicine Hospital and Al Yarmok Nuclear Medicine Department in Baghdad, Iraq were examined for thyroid peroxidase (TPO) gene mutations. A total of ten heterozygous mutations have been identified in the humanTPOgene associated with thyroid toxic and nontoxic goiter. These mutations involved transition or transversion of cysteine either by thymine or guanine at the position 1708 of the exon 10 (c.1708C>T) and the position 1978 of the exon 11 (c.1978C>G). From a total of ten detected mutations, two c.1978C>G mutations were detected in nontoxic goiter patients and eight (two c.1708C>T and six c.1978C>G mutations) were detected in toxic goiter. In conclusion, this study identified ten TPO mutations associated with toxic and nontoxic goiter that have not been yet reported in Iraq, and most of them are detected among females (90 %) and adults age between 30 and 50 years old (80 %).
Genetic Engineering and Biotechnology Institute (GEBI), Baghdad, Iraq.
A H M
AH
Al-Faisal
Research and Development of Medical Diagnostic Laboratories (CMDL), Al-Razi Centre for Medical Diagnostic kits Production, Ministry of Industry, Baghdad, Iraq.
I J
IJ
Al-Ramahi
Genetic Engineering and Biotechnology Institute (GEBI), Baghdad, Iraq.
I A
IA
Abudl-Hassan
Medical College, University of Basrah, Basrah, Iraq.
A T
AT
Hamdan
Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40002 Thailand.
S
S
Barusrux
Mutation; TPO; Thyroid disorders; c.1708C>T; c.1978C>G