IL-17 and IL-22 serum cytokine levels in patients with squamous intraepithelial lesion and invasive cervical carcinoma.
OBJECTIVE
Several works correlate the synthesis of IL-17 and IL-22 with tumoral progression. However, there are no studies of these cytokines on cervical cancer. The authors studied the concentration of IL-17 and IL-22 on serum obtained from patients with different grades of squamous intraepithelial lesions (SILs) and invasive cervical carcinoma.


METHODS
Eighty-one women were enrolled in this study, including 23 in the healthy control (with no history of infection or lesions), 11 with low-grade squamous intraepithelial lesion (LSIL), 36 with high-grade squamous intraepithelial lesion (HSIL), and 11 who were diagnosed anatomo-pathologically with invasive carcinoma. Levels of the IL-17 and IL-22 cytokines were measured in the serum obtained from these patients using the enzyme-linked immunoabsorbent assay (ELISA) method.


RESULTS
IL-17 and IL-22 displayed a similar pattern of results, with an increase in the serum level of LSIL patients, when compared with serum from HSIL patients (respectively, mean- pg/ml: 22.50 vs 12.20, and 168.2 vs 61.48, p < 0.05).


CONCLUSIONS
Concentrations of IL-17 and IL-22 in the peripheral blood of patients with LSIL were increased compared to HSIL patients.
Oncology Research Institute, IPON, Federal University of Triangulo Mineiro (UFTM), Uberaba, MG, Brazil.
J M
JM
Souza
Oncology Research Institute, IPON, Federal University of Triangulo Mineiro (UFTM), Uberaba, MG, Brazil.
B F
BF
Matias
Oncology Research Institute, IPON, Federal University of Triangulo Mineiro (UFTM), Uberaba, MG, Brazil.
C M
CM
Rodrigues
Oncology Research Institute, IPON, Federal University of Triangulo Mineiro (UFTM), Uberaba, MG, Brazil.
E F C
EF
Murta
Oncology Research Institute, IPON, Federal University of Triangulo Mineiro (UFTM), Uberaba, MG, Brazil.
M A
MA
Michelin
D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D007378:Interleukins / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000276:immunology*; D002578:Uterine Cervical Dysplasia / Q000276:immunology*; D000097043:Interleukin-22
D020381:Interleukin-17; D007378:Interleukins; D000097043:Interleukin-22