Unusual intracytoplasmic crystalline inclusions in chronic myelomonocytic leukemia with double minute chromosomes and MYC amplification: a rare case.
Chronic myelomonocytic leukemia (CMML) is a clonal hematological disease characterized by the presence of peripheral blood monocytosis and bone marrow dysplasia. Double minute chromosomes (dmin) are rare and intracytoplasmic crystalline inclusions are very rare in hematologic malignancies. We present a case of CMML with dmin and unusual intracytoplasmic crystalline inclusions. To our knowledge, no such case has previously been reported.
Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan.
Kanji
K
Miyazaki
Kenshi
K
Suzuki
D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002890:Chromosomes, Human, Pair 20; D005784:Gene Amplification; D016259:Genes, myc; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D002479:Inclusion Bodies / Q000648:ultrastructure*; D007621:Karyotyping; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics* / Q000473:pathology*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged