Biomarkers for early detection of risk in female patients with coronary artery disease: pilot study.
In women with coronary artery disease (CAD), clinical presentation is different enough from men which leads to missed or delayed diagnosis. Biomarkers can be used for assessment of CAD patients. In case control study, we analyzed blood samples of 30 controls, 30 cases of Unstable Angina (UA) and 30 cases of Myocardial Infarction (MI) for Pro-inflammatory markers (hs-CRP, IL-6, ICAM-1) and Pregnancy Associated Plasma Protein-A (PAPP-A). Based on discriminant analysis, hs-CRP is the potential marker to discriminate cases of UA from controls while PAPP-A is the reliable marker which can discriminate the cases of MI from UA and controls.
Department of Biochemistry, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-110095.
Sunita
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Mahto
Department of Biochemistry, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-110095.
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Sharma
Coronary Care Unit, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-110095
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Dwivedi
Department of Biochemistry, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-110095.
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Puri
Department of Biochemistry, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-110095.
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Tripathi
D000328:Adult; D000368:Aged; D000789:Angina, Unstable / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D010865:Pilot Projects; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D012307:Risk Factors
D015415:Biomarkers; D002097:C-Reactive Protein; D011266:Pregnancy-Associated Plasma Protein-A