Outpatient consumption of antibiotics in the City of Zagreb (2006-2010).
OBJECTIVE
To investigate outpatient consumption of antibiotics during the 2006-2010 period in the City of Zagreb and compare it with other European countries.


METHODS
Data on outpatient consumption of antibiotics were obtained from all pharmacies in the City of Zagreb. Based on the data obtained, the number of defined daily doses per 1000 inhabitants per day (DDDs/TID) were calculated for each ATC subgroup. Drug Utilization 90% (DU90%) method and ratio indicators were used for the assessment of drug prescribing quality.


RESULTS
During the period of five years total antibiotics consumption has declined from 37.38 DDDs/TID in 2006 to 33.28 DDDs/ TID in 2010. The most frequently prescribed subgroup was penicillins (J01C). DU90% segment included 10 out of a total of 32 antibiotics in the year 2006 and 10 out of a total of 23 antibiotics in the year 2010. Leading position in the consumption, in 2006 and 2010, was held by broad-spectrum antibiotics, moreover their consumption increased in 2010.


CONCLUSIONS
Consumption of antibiotics in Zagreb is still very high and is similar to the consumption in European countries with the highest consumption of antibiotics. Reduced consumption of narrow-spectrum antibiotics and unjustified increase in the consumption of broad-spectrum antibiotics suggess that physicians do not follow clinical guidelines.
General Practice "Zdenka Orlović, dr. med., spec. obit. med.", Velika Gorica, 2Institute of Public Health Zagreb, 3University of Zagreb, School of Medicine, Zagreb; Croatia.
Anja
A
Golub
Danijela
D
Štimac
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017523:Croatia; D004363:Drug Utilization / Q000706:statistics & numerical data*; D005060:Europe; D006801:Humans; D010045:Outpatients; D013997:Time Factors
D000900:Anti-Bacterial Agents