FOXP3-specific immunity.
Forkhead box P3 (FOXP3)-specific cytotoxic CD8+T cells are present among human peripheral blood mononuclear cells (PBMCs), especially in cancer patients. Such T lymphocytes are able not only to specifically recognize dendritic cells (DCs) that have been exposed to recombinant FOXP3 and regulatory T cells, but also to kill FOXP3+malignant T cells. The natural occurrence of FOXP3-specific cytotoxic T lymphocytes among human PBMCs suggests a general role for these cells in the complex network of immune regulation.
Center for Cancer Immune Therapy (CCIT); Department of Hematology; Copenhagen University Hospital; Herlev, Denmark.
Mads Hald
MH
Andersen
CTL; HLA class I restricted T-cell epitope; Tregs; antigen; foxp3