Efficacy of vitamin E to prevent dermal complications of isotretinoin.
Acne treatment depends on whether patents have a mild, moderate, or severe type of acne. The aim of this study was to compare the using of Isotretinoin (Rokutan) with and without oral vitamin E in treating acne. This study was performed on 60 patients on 0.5 mg/kg/day isotretinoin treatment for 6 months. The first group received 800 IU day(-1) Vit E during treatment and the second group recieved 800 Iu day(-1) cod liver oil capsules. All patients were observed for the complications at 1th, 4th and 6th weeks during treatment. Cheilitis was the most common side effect among these patients (69%). Epistaxis was the second side effect in both groups (22%). Other side effects were xerosis, pruritus, epigastric pain and nail fragility. The frequency and the severity of complications were less common at 4th and 6th weeks of treatment. Isotretinoin is a useful and effective drug in treating severe and treatment-resistance acne lesions.
Department of Dermatology, Tabriz University of Medical Sciences, Tabriz, Iran.
Farideh
F
Goforoushan
Department of Dermatology, Tabriz University of Medical Sciences, Tabriz, Iran.
Hamideh
H
Azimi
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohamad
M
Goldust
D000152:Acne Vulgaris / Q000175:diagnosis / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002214:Capsules; D002613:Cheilitis / Q000209:etiology / Q000517:prevention & control; D016009:Chi-Square Distribution; D003060:Cod Liver Oil / Q000008:administration & dosage; D003879:Dermatologic Agents / Q000009:adverse effects*; D004844:Epistaxis / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects*; D008297:Male; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014810:Vitamin E / Q000008:administration & dosage*; D055815:Young Adult
D002214:Capsules; D003879:Dermatologic Agents; D014810:Vitamin E; D003060:Cod Liver Oil; D015474:Isotretinoin