Maternal serum analyte screening for fetal aneuploidy.
In the first and second trimesters, chemicals produced by the fetoplacental unit are measured to assess risks of fetal abnormalities. Consistent associations between levels of these proteins in such pregnancies enable these biomarkers to be used to calculate risk for Down syndrome and other chromosomal abnormalities in individual pregnancies. Special consideration may be required when assessing risk in multiple pregnancies and pregnancies achieved with infertility therapy.
*NewYork-Presbyterian Hospital; †Weill Cornell Medical College, New York, New York.
Stephen T
ST
Chasen
D000782:Aneuploidy; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood* / Q000378:metabolism; D025063:Chromosome Disorders / Q000097:blood* / Q000175:diagnosis / Q000378:metabolism; D002882:Chromosomes, Human, Pair 13; D002887:Chromosomes, Human, Pair 18 / Q000378:metabolism; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D004964:Estriol / Q000097:blood; D005260:Female; D006801:Humans; D007265:Inhibins / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D011272:Pregnancy, Multiple / Q000097:blood*; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011296:Prenatal Diagnosis / Q000379:methods*; D027724:Reproductive Techniques, Assisted; D014314:Trisomy / Q000175:diagnosis; D000073839:Trisomy 13 Syndrome; D000073842:Trisomy 18 Syndrome; D000509:alpha-Fetoproteins / Q000378:metabolism*
D015415:Biomarkers; D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins; C422362:inhibin A; D007265:Inhibins; D011266:Pregnancy-Associated Plasma Protein-A; C579283:PAPPA protein, human; D004964:Estriol