Protein conformation as a regulator of cell-matrix adhesion.
The dynamic regulation of cell-matrix adhesion is essential for tissue homeostasis and architecture, and thus numerous pathologies are linked to altered cell-extracellular matrix (ECM) interaction and ECM scaffold. The molecular machinery involved in cell-matrix adhesion is complex and involves both sensory and matrix-remodelling functions. In this review, we focus on how protein conformation controls the organization and dynamics of cell-matrix adhesion. The conformational changes in various adhesion machinery components are described, including examples from ECM as well as cytoplasmic proteins. The discussed mechanisms involved in the regulation of protein conformation include mechanical stress, post-translational modifications and allosteric ligand-binding. We emphasize the potential role of intrinsically disordered protein regions in these processes and discuss the role of protein networks and co-operative protein interactions in the formation and consolidation of cell-matrix adhesion and extracellular scaffolds.
University of Tampere, Institute of Biomedical Technology and BioMediTech, Biokatu 6, 33520 Tampere, Finland.
Vesa P
VP
Hytönen
Bernhard
B
Wehrle-Haller
D000185:Actinin / Q000737:chemistry / Q000378:metabolism; D000494:Allosteric Regulation; D000081247:CSK Tyrosine-Protein Kinase; D002448:Cell Adhesion; D050719:Crk-Associated Substrate Protein / Q000737:chemistry / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000737:chemistry* / Q000378:metabolism; D064448:Filamins / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D016608:Talin / Q000737:chemistry / Q000378:metabolism; D016596:Vinculin / Q000737:chemistry / Q000378:metabolism; D019061:src-Family Kinases / Q000737:chemistry / Q000378:metabolism
D050719:Crk-Associated Substrate Protein; D016326:Extracellular Matrix Proteins; D064448:Filamins; D016608:Talin; D000185:Actinin; D016596:Vinculin; D000081247:CSK Tyrosine-Protein Kinase; D019061:src-Family Kinases