The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder.
Unbiased genome-wide approaches can provide novel insights into the biological pathways that are important for human behavior and psychiatric disorder risk. The association of α-endomannosidase gene (MANEA) variants and cocaine-induced paranoia (CIP) was initially described in a study that used a whole-genome approach. Behavioral effects have been reported for other mannosidase genes, but MANEA function in humans and the clinical potential of the previous findings remain unclear. We hypothesized that MANEA would be associated with psychiatric phenotypes unrelated to cocaine use. We used a multi-stage association study approach starting with four psychiatric disorders to show an association between a MANEA single-nucleotide polymorphism (SNP; rs1133503) and anxiety disorders. In the first study of 2073 European American (EA) and 2459 African American subjects mostly with comorbid drug or alcohol dependence, we observed an association in EAs of rs1133503 with panic disorder (PD) (191 PD cases, odds ratio (OR)=1.7 (95% confidence interval (CI): 1.22-2.41), P=0.002). We replicated this finding in an independent sample of 142 PD cases (OR =1.53 (95% CI: 1.00-2.31), P=0.043) and extended it in an independent sample of 131 generalized social anxiety disorder cases (OR=2.15 (95% CI: 1.27-3.64), P=0.004). MANEA alleles and genotypes were also associated with gene expression differences in whole blood cells. Using publically available data, we observed a consistent effect on expression in brain tissue. We conclude that pathways involving α-endomannosidase warrant further investigation in relation to anxiety disorders.
1] Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA [2] VA CT Health Care Center, West Haven, CT, USA.
K P
KP
Jensen
Departments of Psychiatry and Family & Preventive Medicine, University of California San Diego, La Jolla, CA, USA.
M B
MB
Stein
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine and the VISN4 MIRECC, Philadelphia VA Medical Center, Philadelphia, PA, USA.
H R
HR
Kranzler
1] Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA [2] VA CT Health Care Center, West Haven, CT, USA.
B Z
BZ
Yang
Departments of Medicine, Neurology, Ophthalmology, Genetics and Genomics, Epidemiology, and Biostatistics, Boston University School of Medicine and Public Health, Boston, MA, USA.
L A
LA
Farrer
1] Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA [2] VA CT Health Care Center, West Haven, CT, USA [3] Departments of Genetics and Neurobiology, Yale University School of Medicine, New Haven, CT, USA.
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Gelernter
D000328:Adult; D001741:Black or African American / Q000235:genetics* / Q000706:statistics & numerical data; D001773:Blood Cells / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D015897:Comorbidity; D005260:Female; D015870:Gene Expression / Q000235:genetics; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008361:Mannosidases / Q000235:genetics* / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D016584:Panic Disorder / Q000453:epidemiology / Q000235:genetics*; D010698:Phobic Disorders / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000235:genetics; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics* / Q000706:statistics & numerical data; D055815:Young Adult
D008565:Membrane Proteins; C505100:MANEA protein, human; D008361:Mannosidases