Whole eye axial biometry during accommodation using ultra-long scan depth optical coherence tomography.
OBJECTIVE
To investigate changes of whole eye axial biometry during accommodation using ultra-long scan depth optical coherence tomography (UL-OCT).


METHODS
Prospective, observational case series.


METHODS
Twenty-one adult subjects were enrolled. Using UL-OCT, the left eye of each subject was imaged with relaxed diopters (0 D) and accommodative stimuli (+6 D). Full eye biometry included central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness, vitreous length, and axial length (AL).


RESULTS
During accommodation (+6 D), the axial biometry of the whole eye changed significantly. Compared to the rest state, ACD at the accommodative state decreased significantly from 3.128 ± 0.305 mm to 2.961 ± 0.298 mm (paired t test, P < .001). The lens thickness increased significantly from 3.723 ± 0.237 mm to 3.963 ± 0.234 mm (P < .001). The vitreous length decreased significantly from 17.129 ± 0.864 mm to 17.057 ± 0.848 mm (P < .001). AL was 24.519 ± 0.917 mm at the rest state and increased to 24.545 ± 0.915 mm with +6 D accommodation stimulus. The elongated AL of 26.1 ± 13.4 μm between the rest and accommodative states was significant (P < .001).


CONCLUSIONS
During accommodation, whole eye axial biometry changed, including a decrease in ACD and vitreous length and an increase in lens thickness and AL. UL-OCT provides an alternative method that is suitable for full eye biometry during accommodation.
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Hangzhou First People's Hospital, Zhejiang, China.
Jianguang
J
Zhong
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, China.
Aizhu
A
Tao
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, China.
Zhe
Z
Xu
Hangzhou First People's Hospital, Zhejiang, China.
Hong
H
Jiang
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, China.
Yilei
Y
Shao
Hangzhou First People's Hospital, Zhejiang, China.
Huicheng
H
Zhang
Department of Biomedical Engineering, University of Miami, Miami, Florida.
Che
C
Liu
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address: jwang3@med.miami.edu.
Jianhua
J
Wang
D000065:Accommodation, Ocular / Q000502:physiology*; D000328:Adult; D000867:Anterior Chamber / Q000033:anatomy & histology; D058452:Axial Length, Eye / Q000033:anatomy & histology*; D001699:Biometry; D003315:Cornea / Q000033:anatomy & histology; D005260:Female; D006801:Humans; D007908:Lens, Crystalline / Q000033:anatomy & histology; D008297:Male; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014822:Vitreous Body / Q000033:anatomy & histology; D055815:Young Adult