Stereospecific nickel-catalyzed cross-coupling reactions of alkyl Grignard reagents and identification of selective anti-breast-cancer agents.
Alkyl Grignard reagents that contain β-hydrogen atoms were used in a stereospecific nickel-catalyzed cross-coupling reaction to form C(sp(3))-C(sp(3)) bonds. Aryl Grignard reagents were also utilized to synthesize 1,1-diarylalkanes. Several compounds synthesized by this method exhibited selective inhibition of proliferation of MCF-7 breast cancer cells.
Department of Chemistry, University of California, Irvine Irvine, CA 92697 (USA).
Ivelina M
IM
Yonova
Department of Chemistry, University of California, Irvine Irvine, CA 92697 (USA).
A George
AG
Johnson
Department of Chemistry, University of California, Irvine Irvine, CA 92697 (USA).
Charlotte A
CA
Osborne
Department of Chemistry and Biochemistry, University of California, San Diego La Jolla, CA 92093 (USA).
Curtis E
CE
Moore
Department of Molecular Biology & Biochemistry, University of California, Irvine.
Naomi S
NS
Morrissette
Department of Chemistry, University of California, Irvine Irvine, CA 92697 (USA).
Elizabeth R
ER
Jarvo
D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002384:Catalysis; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism
D000473:Alkanes; D000970:Antineoplastic Agents; D006841:Hydrocarbons, Aromatic; D007202:Indicators and Reagents; D009532:Nickel
Kumada coupling; alkyl Grignard reagents; breast cancer; enantiospecificity; nickel