Case report: an atypical peripapillary uveal melanoma.
BACKGROUND
The treatment of uveal melanoma has seen a shift towards eye conserving treatments. Efforts have been made towards the identification of patients at high risk of metastatic disease with the use of prognostic fine needle biopsy, Monosomy 3 a risk factor for metastatic death thought to occur early in the development of uveal melanoma.


METHODS
We report a case in which an atypical optic nerve lesion was found to be a peripapillary primary uveal melanoma with distinct non-pigmented and pigmented halves on gross dissection and corresponding disomy 3 and monosomy 3 halves. The tumour demonstrated rapid growth with apparent transformation from disomy 3 to monosomy 3.


CONCLUSIONS
These are clinical features that challenge the current concepts of the cytogenetic pathogenesis of uveal melanoma and demonstrate the potential problems and limitations of prognostic fine needle biopsy and molecular classifications.
The Henry C, Witelson Ocular Pathology Laboratory, McGill University, 3775 University St,, Room 216, Montreal, QC H3A 2B4, Canada. limlianne@gmail.com.
Li-Anne
LA
Lim
Cristina
C
Miyamoto
Paula
P
Blanco
Silvin
S
Bakalian
Miguel N
MN
Burnier
D044963:Biopsy, Fine-Needle; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D014602:Uvea / Q000473:pathology*; D014604:Uveal Neoplasms / Q000235:genetics / Q000473:pathology*