No evidence of association between functional polymorphisms located within IL6R and IL6ST genes and Henoch-Schönlein purpura.
Henoch-Schönlein purpura (HSP) is the most common type of primary small-sized blood vessel vasculitis in children and an uncommon condition in adults. Interleukin (IL)-6 is a proinflammatory cytokine whose effect is controlled by the IL-6 receptor (IL-6R). IL-6 transducer (IL-6ST/gp130) is the signal-transducing subunit of the IL-6R. Two hundred and eighty five Spanish HSP patients and 877 sex and ethnically matched controls were genotyped for the IL6R rs2228145 and IL6ST/gp130 rs2228044 functional polymorphisms. No significant differences in the genotype and allele frequencies between HSP patients and controls were observed. Moreover, there were no differences between HSP patients according to the age at disease onset, presence of nephritis or gastrointestinal manifestations. Our results do not confirm association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with HSP.
Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IFIMAV, Santander, Spain.
R
R
López-Mejías
B
B
Sevilla Pérez
F
F
Genre
S
S
Castañeda
N
N
Ortego-Centeno
J
J
Llorca
B
B
Ubilla
R
R
Ochoa
T
T
Pina
A
A
Marquez
L
L
Sala-Icardo
J A
JA
Miranda-Filloy
J
J
Rueda-Gotor
J
J
Martín
R
R
Blanco
M A
MA
González-Gay
D000328:Adult; D002648:Child; D050822:Cytokine Receptor gp130 / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011695:IgA Vasculitis / Q000235:genetics* / Q000276:immunology; D008297:Male; D011110:Polymorphism, Genetic; D019947:Receptors, Interleukin-6 / Q000235:genetics*; D013030:Spain
C494199:IL6ST protein, human; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130
Henoch–Schönlein purpura; IL6R; IL6ST; polymorphisms; rs2228044; rs2228145; vasculitis