Preventing kidney injury in children with neurogenic bladder dysfunction.
The most common cause of neurogenic bladder dysfunction (NBD) in newborn infants is myelomeningocele. The pathophysiology almost always involves the bladder detrusor sphincter dyssynergy (DSD), which if untreated can cause severe and irreversible damage to the upper and lower urinary tracts. Early diagnosis and adequate management of NBD is critical to prevent both renal damage and bladder dysfunction and to reduce chances for the future surgeries. Initial investigation of the affected newborn infant includes a renal and bladder ultrasound, measurement of urine residual, determination of serum creatinine level, and urodynamics study. Voiding cystogram is indicated when either hydronephrosis or DSD is present. The main goal of treatment is prevention of urinary tract deterioration and achievement of continuance at an appropriate age. Clean intermittent catheterization (CIC) in combination with anticholinergic (oxybutynin) and antibiotics are instituted in those with high filling and voiding pressures, DSD and/or high grade reflux immediately after the myelomeningocele is repaired. Botulium toxin-A injection into detrusor is a safe alternative in patients with insufficient response or significant side effects to anticholinergic (oral or intravesical instillation) therapy. Surgery is an effective alternative in patients with persistent detrusor hyperactivity and/or dyssynergic detrusor sphincter despites of the CIC and maximum dosage of anticholinergic therapy. Children with NBD require care from a multidisciplinary team approach consisting of pediatricians, neurosurgeon, urologist, nephrologists, orthopedic surgeon, and other allied medical specialists.
Department of Pediatrics, Division of Nephrology, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Faezeh Javadi
FJ
Larijani
Department of Pediatrics, Division of Nephrology, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Mastaneh
M
Moghtaderi
Department of Pediatrics, Division of Nephrology, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Nilofar
N
Hajizadeh
Department of Pediatrics, Division of Nephrology, Rush University Medical Center, Chicago, IL, USA.
Farahnak
F
Assadi
Anticholinergic; botulinum toxin; chronic kidney failure; clean intermittent catheterization; neurogenic bladder dysfunction