Physiologically based pharmacokinetic-pharmacodynamic modeling to the rescue: understanding how resuscitation from local anesthetic overdose with lipid emulsions works.
From Simcyp (Certara) Ltd., Sheffield, United Kingdom.
Geoffrey T
GT
Tucker
D000818:Animals; D002045:Bupivacaine / Q000633:toxicity*; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D006323:Heart Arrest / Q000139:chemically induced* / Q000628:therapy*; D008297:Male; D012151:Resuscitation / Q000379:methods*
D002316:Cardiotonic Agents; D005217:Fat Emulsions, Intravenous; D002045:Bupivacaine