Evidence of human neurocysticercosis in Slovenia.
To assess the prevalence of Taenia solium cysticercosis in patients with neurological disorders in Slovenia, serum/cerebrospinal fluid (CSF) samples from 348 suspected patients were collected between the beginning of January 2001 and the end of December 2012 and analysed serologically for the presence of anti-T. solium IgG antibodies. Of 20 patients whose samples tested positive or equivocal by enzyme-linked immunosorbent assay (ELISA), samples of 7 patients were confirmed positive by Western blot (WB). The overall seroprevalence rate of T. solium infection in patients with neurological disorders included in the study was 2.0%. Serological results of positive patients corresponded to clinical and/or imaging findings concerning their brain cysts. Based on their personal data, it was ascertained that neurocysticercosis (NCC) positive patients had immigrated or came to Slovenia from the former Yugoslav republics. Since the disease is believed not to be endemic in Slovenia we assume that all of the NCC-positive patients had acquired the infection before immigration to Slovenia or visiting or being visited by their relatives infected with an adult T. solium parasite. The present results represent the first insight into the prevalence of NCC in patients with neurological disorders in Slovenia.
Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia.
Barbara
B
Šoba
Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1000 Ljubljana, Slovenia.
Bojana
B
Beović
Department of Infectious Diseases, University Medical Centre Ljubljana, Japljeva 2, 1000 Ljubljana, Slovenia.
Zala
Z
Lužnik
Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia.
Miha
M
Skvarč
Faculty of Medicine, Institute of Microbiology and Immunology, University of Ljubljana, Zaloška 4, 1000 Ljubljana, Slovenia.
Jernej
J
Logar
D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth / Q000097:blood*; D015153:Blotting, Western; D001921:Brain / Q000469:parasitology; D003710:Demography; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007814:Larva; D008297:Male; D008875:Middle Aged; D020019:Neurocysticercosis / Q000469:parasitology*; D016036:Seroepidemiologic Studies; D017524:Slovenia / Q000453:epidemiology; D041201:Taenia solium / Q000276:immunology* / Q000302:isolation & purification
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D007074:Immunoglobulin G