Perioperative conjunctival inflammation and trabeculectomy outcome.
OBJECTIVE
To correlate subclinical conjunctival inflammation and trabeculectomy results.


METHODS
Prospective case series of 28 patients with primary open-angle glaucoma (28 eyes) under topical anti-glaucoma medication who underwent trabeculectomy. During surgery, a sample from the inferior bulbar conjunctiva was collected and the expression of HLA-DR together with the presence of inflammatory cells was correlated with trabeculectomy outcomes after 24 months. Surgical success was defined as intraocular pressure between 6 and 20 mmHg irrespective of the use of anti-glaucoma medication.


RESULTS
Five patients missed follow-up visits and were removed from the study. Ten eyes (43.5%) were HLA-DR(+), but no significant differences were observed between eyes with successful and failed surgeries (p = 0.214). There was no significant association between the number of neutrophils and surgical outcomes (p = 0.353).


CONCLUSIONS
The presence of inflammatory cells and expression of the inflammation marker HLA-DR in the conjunctiva did not correlate with the prognosis of trabeculectomy in this study.
Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, School of Medicine of Ribeirão Preto, University of São Paulo , Ribeirão Preto , Brazil .
João Marcello
JM
Furtado
Jayter Silva
JS
Paula
Edson Garcia
EG
Soares
Régia Caroline
RC
Lira
Ana Maria
AM
Rocha
Neifi Hassam Saloum
NH
Dhegaide
Eduardo Melani
EM
Rocha
Eduardo
E
Donadi
Maria de Lourdes Veronese
Mde L
Rodrigues
D000368:Aged; D015415:Biomarkers / Q000378:metabolism; D003228:Conjunctiva / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D003231:Conjunctivitis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006684:HLA-DR Antigens / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D014130:Trabeculectomy; D016896:Treatment Outcome
D015415:Biomarkers; D006684:HLA-DR Antigens
Conjunctiva; HLA-DR; glaucoma; inflammation; trabeculectomy