Computational modeling of transcranial direct current stimulation in the child brain: implications for the treatment of refractory childhood focal epilepsy.
Transcranial direct current stimulation (tDCS) was recently proposed for the treatment of epilepsy. However, the electrode arrangement for this case is debated. This paper analyzes the influence of the position of the anodal electrode on the electric field in the brain. The simulation shows that moving the anode from scalp to shoulder does influence the electric field not only in the cortex, but also in deeper brain regions. The electric field decreases dramatically in the brain area without epileptiform activity.
CNR Consiglio Nazionale delle Ricerche, Istituto di Elettronica e di Ingegneria, dell'Informazione e delle Telecomunicazioni IEIIT, Piazza Leonardo da Vinci 32, Milano 20133, Italy.
Marta
M
Parazzini
Serena
S
Fiocchi
Ilaria
I
Liorni
Alberto
A
Priori
Paolo
P
Ravazzani
D001921:Brain / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology; D002648:Child; D003198:Computer Simulation; D004599:Electric Stimulation Therapy / Q000379:methods*; D004566:Electrodes; D004828:Epilepsies, Partial / Q000503:physiopathology* / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D012535:Scalp; D012782:Shoulder