Cyclin C: an inducer of mitochondrial division hidden in the nucleus.
In response to cellular stress, mitochondria remodel their structure by organelle division and fusion. In this issue of Developmental Cell, Cooper et al. (2014) report that a nuclear protein, cyclin C, is recruited from nuclei to mitochondria upon oxidative stress and promotes mitochondrial division and apoptosis of the cell.
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Yoshihiro
Y
Adachi
Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: hsesaki@jhmi.edu.
Hiromi
H
Sesaki
D002467:Cell Nucleus / Q000378:metabolism*; D056850:Cyclin-Dependent Kinase 8 / Q000378:metabolism*; D063154:Mitochondrial Dynamics; D018384:Oxidative Stress; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D029701:Saccharomyces cerevisiae Proteins; D056850:Cyclin-Dependent Kinase 8; C498309:SSN3 protein, S cerevisiae