Quality of life in patients with craniocervical dystonia: Italian validation of the "Cervical Dystonia Impact Profile (CDIP-58)" and the "Craniocervical Dystonia Questionnaire (CDQ-24)".
Dystonia is a disabling and disfiguring disorder that can often affect many aspects of patients' daily lives, and lower their self-esteem. To date, quality of life (QoL) has been assessed in dystonic patients using generic measures that do not address the specific problems of this diagnostic group. Recently, two disease-specific scales "The Cervical Dystonia Impact Profile (CDIP-58)" and the "Craniocervical Dystonia Questionnaire (CDQ-24)" were validated for measuring QoL in craniocervical dystonia patients. No disease-specific scales for QoL for dystonic patients are currently available in Italian. The aim of our study was to produce and validate the Italian version of the CDIP-58 and CDQ-24. We obtained the Italian version of CDQ-24 and CDIP-58 with a back-translation design. Both scales were applied to a population of 94 craniocervical dystonia patients along with the Short Form 36 health-survey questionnaire (SF-36), both before and 4 weeks after botulinum toxin therapy. A group of 65 controls matched for sex, age and comorbidity underwent the SF-36. Internal consistency was satisfactory for all subscales. Both the CDIP-58 and CDQ-24 showed moderate to high correlations with similar items of the SF-36. Sensitivity to change was confirmed by highly significant improvements in all CDQ-24 subscales and by moderate improvements in three out of eight CDIP-58 subscales and total score. This is the first Italian study on QoL in dystonia patients. We validated the Italian version of two disease-specific questionnaires to evaluate QoL in craniocervical dystonia patients. These scales could be useful for both clinical practice and clinical trials.
IRCCS Institute of Neurological Sciences, Via Altura 3, 40139, Bologna, Italy, margheritafabbrimd@gmail.com.
Margherita
M
Fabbri
Maria
M
Superbo
Giovanni
G
Defazio
Cesa Lorella Maria
CL
Scaglione
Elena
E
Antelmi
Giacomo
G
Basini
Stefania
S
Nassetti
Fabio
F
Pizza
Rosaria
R
Plasmati
Rocco
R
Liguori
D065087:Acetylcholine Release Inhibitors / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D001905:Botulinum Toxins / Q000627:therapeutic use; D002574:Cervical Vertebrae / Q000503:physiopathology*; D020821:Dystonic Disorders / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology*; D005260:Female; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014175:Translating; D016896:Treatment Outcome
D065087:Acetylcholine Release Inhibitors; D001905:Botulinum Toxins