Palladium-catalyzed double alkylation of 3-aryl-2-fluoroallyl esters with malonate nucleophiles through the carbon-fluorine bond cleavage.
The alkylation of (Z)-3-aryl-2-fluoroallyl acetate with the malonate anion by the [Pd(C3H5)(cod)]BF4/2,2'-bpy catalyst proceeds through the carbon-fluorine bond cleavage, and 2 equiv of the malonate nucleophile was introduced to the allyl substrate.
Department of Chemistry, College of Humanities & Sciences, Nihon University , Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan.
Mitsuaki
M
Yamamoto
Shunsuke
S
Hayashi
Kazuki
K
Isa
Motoi
M
Kawatsura