[Analgesic effect of ferulic acid on CCI mice: behavior and neurobiological analysis].
To study the analgesic effect of chronic administration with ferulic acid, and preliminarily discuss its mechanism. Thermal hyperalgesia and mechanical allodynia tests were conducted to observe the analgesic effect of chronic administration with ferulic acid on CCI mice. The neurochemical detection method was applied to observe the effect chronic administration with ferulic acid on monoamine neurotransmitter and monoamine oxidase activity. Compared with the normal group, CCI mice showed notable reduction in heat sensation and nociceptive threshold in and mechanical allodynia. Ferulic acid (10, 20, 40 and 80 mg x kg(-1), po) could significantly reverse the situations. In an in-depth study, we found that the reason for these results was that ferulic acid was dose-dependent in increasing 5-HT and NE levels in hippocampus, frontal cortex and amygdale and could inhibit MAO-A activity in mouse brains. These results showed that ferulic acid has the analgesic effect. Its mechanism may be related to the inhibition of monoamine oxidase activity and the increase in monoamine neurotransmitter in mouse brains.
Department of Pharmacy, Wenling traditional Chinese medical hospital, Taizhou 317500, China.
Wei-Hong
WH
Lv
Department of Pharmacy, Taizhou Central Hospital, Taizhou 318000, China.
Lu
L
Zhang
Department of Pharmacology, Wenzhou Medical University, Wenzhou 325035, China.
Shu-Juan
SJ
Wu
Department of Pharmacy, Taizhou Central Hospital, Taizhou 318000, China.
Sai-Zhen
SZ
Chen
Department of Pharmacology, Wenzhou Medical University, Wenzhou 325035, China.
Xin-Bo
XB
Zhu
Department of Pharmacology, Wenzhou Medical University, Wenzhou 325035, China.
Jian-Chun
JC
Pan
D000700:Analgesics / Q000008:administration & dosage*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003373:Coumaric Acids / Q000008:administration & dosage*; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy* / Q000523:psychology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008995:Monoamine Oxidase / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D012584:Sciatic Nerve / Q000187:drug effects / Q000293:injuries; D020426:Sciatic Neuropathy / Q000188:drug therapy* / Q000378:metabolism / Q000523:psychology*
D000700:Analgesics; D003373:Coumaric Acids; D018377:Neurotransmitter Agents; C004999:ferulic acid; D008995:Monoamine Oxidase