Decreased serum fetuin-A levels and active inflammatory bowel disease.
BACKGROUND
Fetuin-A is a mediator of inflammatory response that might also be involved in the pathogenesis of inflammatory bowel disease (IBD). This study aims to assess whether serum fetuin-A levels are associated with the disease activity in patients with Crohn's disease (CD) and ulcerative colitis (UC).


METHODS
A total of 139 patients with CD, 114 patients with UC, and 46 controls were enrolled in this study. The serum fetuin-A levels of the participants were measured using commercially available sandwich enzyme-linked immunosorbent assay.


RESULTS
The patients with IBD had significantly lower serum fetuin-A levels compared with the healthy controls. The active patients with CD and patients with UC both had significantly decreased serum fetuin-A levels compared with the inactive patients with CD and patients with UC. Multivariable logistic regression analysis revealed that decreased serum fetuin-A levels were independently associated with the disease activity of CD and UC. Serum fetuin-A levels were negatively associated with C-reactive protein concentrations and white blood cell count in patients with CD but not in patients with UC.


CONCLUSIONS
Decreased serum fetuin-A levels were independently associated with disease activity in patients with CD and UC. The utilization of fetuin-A concentration measurements as markers of disease activity in patients with IBD warrants further investigations.
Department of Gastroenterology (PM, YF), Yan'an University Affiliated Hospital, Yan'an University, Yanan, Shanxi, China; Department of Gastroenterology (PM), The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China.
Peng
P
Ma
Yi-chao
YC
Feng
D000328:Adult; D015415:Biomarkers / Q000097:blood; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis; D003424:Crohn Disease / Q000097:blood / Q000175:diagnosis; D003430:Cross-Sectional Studies; D015536:Down-Regulation / Q000502:physiology; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D060749:alpha-2-HS-Glycoprotein / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism*
C556354:AHSG protein, human; D015415:Biomarkers; D060749:alpha-2-HS-Glycoprotein