Recognition and neutralization of angiotensins I and II using an artificial nanogel receptor fabricated by ligand specificity determinant imprinting.
A nanogel combined with a molecularly imprinted polymer (MIP-nanogel) receptor was prepared using the specificity determinant as a template in aqueous media. The artificial receptor can serve as the selective recognition element for angiotensins I and II and a novel way to control hypertension was investigated.
School of Chemistry and Environment, MOE Key Laboratory of Laser Life Science, South China Normal University, 510006 Guangzhou, China. tanglab@scnu.edu.cn.
Zerong
Z
Yu
Zhiguang
Z
Xu
He
H
Li
Jianwen
J
Chen
Zhiying
Z
Huang
Youwen
Y
Tang
D000803:Angiotensin I / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure; D008024:Ligands; D054802:Molecular Imprinting; D049329:Nanostructures; D051381:Rats; D011945:Receptors, Angiotensin / Q000737:chemistry* / Q000378:metabolism*
D008024:Ligands; D011945:Receptors, Angiotensin; D000804:Angiotensin II; D000803:Angiotensin I