Association of KCNQ1 and KLF14 polymorphisms and risk of type 2 diabetes mellitus: A global meta-analysis.
rs151290 in KCNQ1 and rs972283 in KLF14 have been evaluated in terms of risk of type 2 diabetes mellitus (T2DM), but the results are inconsistent. We performed an meta-analysis to assess the contributions of rs151290 in KCNQ1 and rs972283 in KLF14 to risk of T2DM. We searched the worldwide literature published from 2008 to 2013 in MEDLINE via PubMed, EMBASE, Cochrane CENTRAL and Chinese databases. Two reviewers extracted data independently using a standardized protocol, and any discrepancies were resolved by a third reviewer. Fixed- and random-effects meta-analyses were performed to pool the odds ratios (ORs). Publication bias and heterogeneity were examined. A total of 11 articles were included in the meta-analysis: 6 studies with 6696 cases and 7151 controls investigated rs151290 in KCNQ1, and 5 studies with 50,552 cases and 106,535 controls investigated rs972283 in KLF14. We obtained highly significant ORs for the risk allele C for rs151290 and the risk allele G for rs972283. The population attributable risk percentage for rs151290 and rs972283 was 6.83% and 4.18%, respectively. The risk allele C of rs151290 in KCNQ1 and risk allele G of rs972283 in KLF14 were both associated with increased risk of T2DM in a global population.
Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China. Electronic address: wangjinjin510@163.com.
Jinjin
J
Wang
Henan Armed Police Corps Hospital, Zhengzhou 450000, People's Republic of China. Electronic address: jeefzhang106@163.com.
Jianfeng
J
Zhang
Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China. Electronic address: besdwujing1@163.com.
Jie
J
Shen
Shenzhen University School of Medicine, Shenzhen 518060, People's Republic of China. Electronic address: dongsheng_hu@hotmail.com.
Dongsheng
D
Hu
Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China. Electronic address: 15937168725@163.com.
Guoli
G
Yan
Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China. Electronic address: judylxh@163.com.
Xiaohui
X
Liu
Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China. Electronic address: xxqteresa@126.com.
Xueqin
X
Xu
Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China. Electronic address: peilanying@yahoo.com.cn.
Lanying
L
Pei
Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China. Electronic address: liyanfang2004@126.com.
Yanfang
Y
Li
Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, People's Republic of China. Electronic address: sunchunyang427@163.com.
Chunyang
C
Sun
D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D051657:KCNQ1 Potassium Channel / Q000235:genetics*; D051741:Kruppel-Like Transcription Factors; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D012306:Risk; D051703:Sp Transcription Factors / Q000235:genetics*
D051657:KCNQ1 Potassium Channel; C417549:KLF14 protein, human; D051741:Kruppel-Like Transcription Factors; D051703:Sp Transcription Factors