Birth outcomes and maternal residential proximity to natural gas development in rural Colorado.
BACKGROUND
Birth defects are a leading cause of neonatal mortality. Natural gas development (NGD) emits several potential teratogens, and U.S. production of natural gas is expanding.


OBJECTIVE
We examined associations between maternal residential proximity to NGD and birth outcomes in a retrospective cohort study of 124,842 births between 1996 and 2009 in rural Colorado.


METHODS
We calculated inverse distance weighted natural gas well counts within a 10-mile radius of maternal residence to estimate maternal exposure to NGD. Logistic regression, adjusted for maternal and infant covariates, was used to estimate associations with exposure tertiles for congenital heart defects (CHDs), neural tube defects (NTDs), oral clefts, preterm birth, and term low birth weight. The association with term birth weight was investigated using multiple linear regression.


RESULTS
Prevalence of CHDs increased with exposure tertile, with an odds ratio (OR) of 1.3 for the highest tertile (95% CI: 1.2, 1.5); NTD prevalence was associated with the highest tertile of exposure (OR = 2.0; 95% CI: 1.0, 3.9, based on 59 cases), compared with the absence of any gas wells within a 10-mile radius. Exposure was negatively associated with preterm birth and positively associated with fetal growth, although the magnitude of association was small. No association was found between exposure and oral clefts.


CONCLUSIONS
In this large cohort, we observed an association between density and proximity of natural gas wells within a 10-mile radius of maternal residence and prevalence of CHDs and possibly NTDs. Greater specificity in exposure estimates is needed to further explore these associations.
Department of Environmental and Occupational Health, and.
Lisa M
LM
McKenzie
Ruixin
R
Guo
Roxana Z
RZ
Witter
David A
DA
Savitz
Lee S
LS
Newman
John L
JL
Adgate
D002972:Cleft Palate / Q000139:chemically induced / Q000453:epidemiology; D003120:Colorado; D005260:Female; D006330:Heart Defects, Congenital / Q000139:chemically induced / Q000453:epidemiology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure; D059206:Natural Gas / Q000633:toxicity*; D009436:Neural Tube Defects / Q000139:chemically induced / Q000453:epidemiology; D016017:Odds Ratio; D011247:Pregnancy; D047928:Premature Birth / Q000139:chemically induced / Q000453:epidemiology; D012189:Retrospective Studies
D059206:Natural Gas