Nagelamide I and 2,2'-didebromonagelamide B, new dimeric bromopyrrole-imidazole alkaloids from a marine sponge Agelas sp.
New dimeric bromopyrrole-imidazole alkaloids, nagelamide I (1) and 2,2'-didebromonagelamide B (2), have been isolated from an Okinawan marine sponge Agelas species. The structures of 1 and 2 were elucidated based on analyses of the spectral data. Nagelamide I (1) was the first symmetric dimeric bromopyrrole-imidazole alkaloid consisting of two subunits connected with a single bond.
Graduate School of Pharmaceutical Sciences, Hokkaido University.
Takahiro
T
Iwai
Takaaki
T
Kubota
Jane
J
Fromont
Jun'ichi
J
Kobayashi
D047230:Agelas / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D000818:Animals; D054879:Halogenation; D007093:Imidazoles / Q000737:chemistry* / Q000302:isolation & purification; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification
D000470:Alkaloids; D007093:Imidazoles; D011758:Pyrroles