Association study to evaluate FoxO1 and FoxO3 gene in CHD in Han Chinese.
BACKGROUND
Coronary heart disease (CHD) is one of the leading causes of mortality and morbidity in China. Genetic factors that predispose individuals to CHD are unclear. In the present study, we aimed to determine whether the variation of FoxOs, a novel genetic factor associated with longevity, was associated with CHD in Han Chinese populations.


METHODS
1271 CHD patients and 1287 age-and sex-matched controls from Beijing and Harbin were included. We selected four tagging single nucleotide polymorphisms (SNPs) of FoxO1 (rs2755209, rs2721072, rs4325427 and rs17592371) and two tagging SNPs of FoxO3 (rs768023 and rs1268165). And the genotypes of these SNPs were determined in both CHD patients and non-CHD controls.


RESULTS
For population from Beijing, four SNPs of FoxO1 and two SNPs of FoxO3 were found not to be associated with CHD (p>0.05). And this was validated in the other population from Harbin (p>0.05). After combining the two geographically isolated case-control populations, the results showed that the six SNPs did not necessarily predispose to CHD in Han Chinese(p>0.05). In stratified analysis according to gender, the history of smoking, hypertension, diabetes mellitus, hyperlipidemia and the metabolic syndrome, we further explored that neither the variants of FoxO1 nor the variants of FoxO3 might be associated with CHD (p>0.05).


CONCLUSIONS
The variants of FoxO1 and FoxO3 may not increase the prevalence of CHD in Han Chinese population.
Department of Geriatrics, Jinan Military General Hospital, Jinan, China.
Ying
Y
Zhao
Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, China.
Yanbo
Y
Yu
Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China.
Xiaoli
X
Tian
Department of Human Population Genetics, Institute of Molecular Medicine, Peking University, Beijing, China.
Xi
X
Yang
Department of Cardiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Xueqi
X
Li
Department of Cardiology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Feng
F
Jiang
Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
Yundai
Y
Chen
Department of Geriatrics, Jinan Military General Hospital, Jinan, China.
Maowei
M
Shi
D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D000071161:Forkhead Box Protein O1; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
C085126:FOXO1 protein, human; C499517:FOXO3 protein, human; D000071161:Forkhead Box Protein O1; D000071316:Forkhead Box Protein O3; D051858:Forkhead Transcription Factors