Effects of Collagen Tripeptide Supplement on Photoaging and Epidermal Skin Barrier in UVB-exposed Hairless Mice.
Collagen tripeptide (CTP) is a functional food material with several biological effects such as improving dry skin and wound and bone fracture healing. This study focused on the anti-photoaging effects of CTP on a hairless mouse model. To evaluate the effects of CTP on UVB-induced skin wrinkle formation in vivo, the hairless mice were exposed to UVB radiation with oral administration of CTP for 14 weeks. Compared with the untreated UVB control group, mice treated with CTP showed significantly reduced wrinkle formation, skin thickening, and transepidermal water loss (TEWL). Skin hydration and hydroxyproline were increased in the CTP-treated group. Moreover, oral administration of CTP prevented UVB-induced MMP-3 and -13 activities as well as MMP-2 and -9 expressions. Oral administration of CTP increased skin elasticity and decreased abnormal elastic fiber formation. Erythema was also decreased in the CTP-treated group. Taken together, these results strongly suggest that CTP has potential as an anti-photoaging agent.
Department of Biomaterials Science and Engineering, Yonsei University, Seoul 120-749, Korea.
Hee-Bong
HB
Pyun
Department of Biomaterials Science and Engineering, Yonsei University, Seoul 120-749, Korea.
Minji
M
Kim
Department of Biotechnology, and College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.
Jieun
J
Park
Central Research Institute, Jellice Co., Ltd., Sendai, Miyagi 984-0826, Japan.
Yasuo
Y
Sakai
Central Research Institute, Jellice Co., Ltd., Sendai, Miyagi 984-0826, Japan.
Noriaki
N
Numata
Amorepacific Corporation R&D Center, Gyeonggi 446-729, Korea.
Jin-Yeong
JY
Shin
Amorepacific Corporation R&D Center, Gyeonggi 446-729, Korea.
Hyun-Jung
HJ
Shin
Food R&D Center, Newtree Co., Ltd, Gyeonggi, 462-120, Korea.
Do-Un
DU
Kim
Department of Biomaterials Science and Engineering, Yonsei University, Seoul 120-749, Korea ; Department of Biotechnology, and College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea.
Jae-Kwan
JK
Hwang
collagen tripeptide (CTP); matrix metalloproteinases (MMPs); photoaging; transepidermal water loss (TEWL); wrinkle formation