Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment: The many facets of tumor-derived oxysterols.
By binding to the liver X receptor (LXR), oxysterols inhibit the expression of chemokine (C-C motif) receptor 7 (CCR7), hence impairing the migration of dendritic cells to secondary lymphoid organs and inhibiting antitumor immune responses. We have recently identified a new tumor-supporting activity of oxysterols, which recruit neutrophils within tumor microenvironment by a chemokine (C-X-C motif) receptor 2 (CXCR2)-dependent, LXR-independent mechanism.
Cancer Gene Therapy Unit; Division of Molecular Oncology; San Raffaele Scientific Institute; Milan, Italy.
Laura
L
Raccosta
Cancer Gene Therapy Unit; Division of Molecular Oncology; San Raffaele Scientific Institute; Milan, Italy.
Raffaella
R
Fontana
MolMed SpA; Milan, Italy.
Catia
C
Traversari
Cancer Gene Therapy Unit; Division of Molecular Oncology; San Raffaele Scientific Institute; Milan, Italy.
Vincenzo
V
Russo
CXCR2; immune evasion; microenvironment; oxysterols; tumor-infiltrating neutrophils