[Research on the correlation between Chinese medical syndrome types and objective indices of Wilson's disease].
OBJECTIVE
To explore the correlation between Chinese medical syndrome types of Wilson's disease (WD) and clinical materials as well as physical and chemical indices.


METHODS
Totally 116 WD patients were typed by Chinese medical syndrome. The correlation between Chinese medical syndrome types and clinical materials as well as physical and chemical indices were analyzed using binary stepwise Logistic regression by SPSS 19.0 Software, taking the common Chinese medical syndrome types as the dependent variable and clinical materials as well as physical and chemical indices as the independent variables.


RESULTS
Gan-Galibladder dampness-heat syndrome (GGDHS, 35.3%). Gan-stagnation and Pi-deficiency syndrome (GSPDS, 13.8%), Gan-Shen yin deficiency syndrome (GSYDS, 13.8%), and phlegm-dampness retention syndrome (PDRS, 12.1%) were most often seen. GGDHS was positively correlated with grade of K-F ring, total bilirubin (TBIL), alanine transaminase (ALT), laminin (LN) (P < 0.01). GSYDS was positively correlated with TBIL (P < 0.01). PDRS was positively correlated with clinical types, ceruloplasmin (CP), aspartate aminotransferase (AST), and total protein (TP) (P < 0.01, P < 0.05). Qi blood deficiency syndrome was positively correlated with disease course, blood ammonia, blood urea nitrogen (BUN), and LN (P < 0.01, P < 0.05).


CONCLUSIONS
Chinese medical syndrome types were correlated with clinical materials, physical and chemical indices in WD patients, which could provide experimental reference for Chinese medical syndrome typing. GGDHS, GSPDS, GSYDS, and PDRS were most often seen.
Department of Neurology, Institute of Neurology, Anhui College of Traditional Chinese Medicine, Hefei (230061), China. wgq616@163.com
Gong-qiang
GQ
Wang
Department of Neurology, Institute of Neurology, Anhui College of Traditional Chinese Medicine, Hefei (230061), China.
Xin-feng
XF
Ma
Department of Neurology, Institute of Neurology, Anhui College of Traditional Chinese Medicine, Hefei (230061), China.
Wei
W
Wang
Department of Neurology, Institute of Neurology, Anhui College of Traditional Chinese Medicine, Hefei (230061), China.
Quan
Q
Sun
Department of Neurology, Institute of Neurology, Anhui College of Traditional Chinese Medicine, Hefei (230061), China.
Zhi-hua
ZH
Zhou
Department of Neurology, Institute of Neurology, Anhui College of Traditional Chinese Medicine, Hefei (230061), China.
Yong-zhu
YZ
Han
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008516:Medicine, Chinese Traditional / Q000379:methods*; D055815:Young Adult