Cyclic peptides as inhibitors of amyloid fibrillation.
Many neurodegenerative diseases, like Parkinson's, Alzheimer's, or Huntington's disease, occur as a result of amyloid protein fibril formation and cell death induced by this process. Cyclic peptides (CPs) and their derivatives form a new class of powerful inhibitors that prevent amyloid fibrillation and decrease the cytotoxicity of aggregates. The strategies for designing CPs are described, with respect to their amino acid sequence and/or conformational similarity to amyloid fibrils. The implications of CPs for the study and possible treatment of amyloid-related diseases are discussed.
Leiden Institute of Chemistry, Leiden University, Gorlaeus Laboratoriesm, Einsteinweg 55 (The Netherlands).
Jinghui
J
Luo
Jan Pieter
JP
Abrahams
D000595:Amino Acid Sequence; D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000378:metabolism; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*
D000682:Amyloid; D016229:Amyloid beta-Peptides; D010456:Peptides, Cyclic
amyloid fibrillation; cyclic peptides; fibrils; inhibitors; mimics; proteins