Serous ovarian cancer signaling pathways.
Ovarian cancer is the most lethal malignancy of the female genital tract, mainly due to the failure of early diagnosis and the limitations posed by the conventional chemotherapies. Current research has focused in the study of cascades of various cellular molecular reactions, known as signaling pathways. In this review article, authors try to describe the current knowledge regarding the signaling pathways that influence multiple cellular processes in serous ovarian cancer and especially the pathogenesis. Thorough understanding of the precise role of these pathways can lead to the development of new and more effective targeted therapies as well as novel biomarkers in ovarian cancer.
*Obstetrics & Gynecology Department, Medical School, University of Patras, Rion; and †1st Obstetrics & Gynecology Department, Medical School, "Aristotle" University of Thessaloniki; ‡Medical Oncology Department, "Euromedica" General Clinic; and §Cytology Department, "Theagenio" Cancer Hospital, Thessaloniki, Greece.
Ioannis C
IC
Kotsopoulos
Alexios
A
Papanikolaou
Alexandros F
AF
Lambropoulos
Konstantinos T
KT
Papazisis
Dimitrios
D
Tsolakidis
Panagiota
P
Touplikioti
Basil C
BC
Tarlatzis
D018284:Cystadenocarcinoma, Serous / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000378:metabolism; D015398:Signal Transduction