Effects of two commonly used mydriatics on choroidal thickness: direct and crossover effects.
OBJECTIVE
To investigate the effect of 2 commonly used mydriatics on choroidal thickness using enhanced depth imaging optical coherence tomography (EDI-OCT).


METHODS
In this prospective study, 90 healthy subjects were enrolled. The participants were randomly divided into 3 groups based on the application of drops. One eye of each subject received a drop of tropicamide 1% in the tropicamide group (n=30), a drop of phenylephrine 2.5% in the phenylephrine group (n=30), and a drop of artificial tear in the control group (n=30). Drops were given thrice at 5 min intervals. Subfoveal choroidal thickness (SFCT) was measured using EDI-OCT before and at 45 min after drop application in both the dilated eye and nondilated contralateral eye.


RESULTS
The SFCT was significantly decreased after drop instillation in both the dilated eye and contralateral eye in the tropicamide group (P<0.001 and P=0.001, respectively) and in the phenylephrine group (P<0.001 and P=0.001, respectively). However, the SFCT did not significantly differ after drop instillation in either the dropped eye or contralateral eye in the control group (P=0.108 and P=0.695, respectively).


CONCLUSIONS
The findings of the present study revealed that tropicamide and phenylephrine cause a decrease in choroidal thickness.
1 Department of Ophthalmology, Sehitkamil Government Hospital , Gaziantep, Turkey .
Necip
N
Kara
Ali
A
Demircan
Gonul
G
Karatas
Engin Bilge
EB
Ozgurhan
Gurkan
G
Tatar
Yalcin
Y
Karakucuk
Abdurrahman
A
Basci
Ahmet
A
Demirok
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult; D002829:Choroid / Q000187:drug effects; D009184:Mydriatics / Q000627:therapeutic use; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D010656:Phenylephrine / Q000627:therapeutic use; D011446:Prospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods; D014331:Tropicamide / Q000627:therapeutic use
D009184:Mydriatics; D009883:Ophthalmic Solutions; D010656:Phenylephrine; D014331:Tropicamide