Hospital-based surveillance of rotavirus gastroenteritis among children under 5 years of age in the Republic of Ivory Coast: a cross-sectional study.
OBJECTIVE
To estimate the proportion of rotavirus gastroenteritis (RVGE) among children aged less than 5 years who had been diagnosed with acute gastroenteritis (AGE) and admitted to hospitals and emergency rooms (ERs). The seasonal distribution of RVGE and most prevalent rotavirus (RV) strains was also assessed.


METHODS
A cross-sectional hospital-based surveillance study.


METHODS
5 reference paediatric hospitals across Abidjan.


METHODS
Children aged less than 5 years, who were hospitalised/visiting ERs for WHO-defined AGE, were enrolled. Written informed consent was obtained from parents/guardians before enrolment. Children who acquired nosocomial infection were excluded from the study.


METHODS
The proportion of RVGE among AGE hospitalisations and ER visits was expressed with 95% exact CI. Stool samples were collected from all enrolled children and were tested for the presence of RV using an enzyme immunoassay. RV-positive samples were serotyped using reverse transcriptase-PCR.


RESULTS
Of 357 enrolled children (mean age 13.6±11.14 months), 332 were included in the final analyses; 56.3% (187/332) were hospitalised and 43.7% (145/332) were admitted to ERs. The proportion of RVGE hospitalisations and ER visits among all AGE cases was 30.1% (95% CI 23.6% to 37.3%) and 26.9% (95% CI 19.9% to 34.9%), respectively. Ninety-five children (28.6%) were RV positive; the highest number of RVGE cases was observed in children aged 6-11 months. The number of GE cases peaked in July and August 2008; the highest percentage of RV-positive cases was observed in January 2008. G1P[8] wild-type and G8P[6] were the most commonly detected strains.


CONCLUSIONS
RVGE causes substantial morbidity among children under 5 years of age and remains a health concern in the Republic of Ivory Coast, where implementation of prevention strategies such as vaccination might help to reduce disease burden.
Pasteur Institute of Ivory Coast/Medical Sciences Training and Research Unit of Bouake, Abidjan, Republic of Ivory Coast.
Chantal
C
Akoua-Koffi
Vincent
V
Asse Kouadio
Jean Jacques
JJ
Yao Atteby
D000208:Acute Disease; D002675:Child, Preschool; D007560:Cote d'Ivoire; D003430:Cross-Sectional Studies; D004636:Emergency Service, Hospital; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D006761:Hospitals; D006801:Humans; D007223:Infant; D008297:Male; D011159:Population Surveillance; D012401:Rotavirus / Q000145:classification / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology; D012621:Seasons
Infectious Diseases; Virology