Prophylactic effectiveness of budesonide inhalation in reducing postoperative throat complaints.
Postoperative sore throat (POST) is one of the main postoperative complaints. This study was to evaluate the efficacy of budesonide inhalation suspension (BIS) in reducing the incidence and severity of POST. One hundred and twenty patients scheduled for thyroid surgery with general anesthesia were enrolled and randomized into three groups. Group A received 200 mcg BIS 10 min prior to the tracheal intubation and received the same treatment 6 and 24 h after extubation. Group B received 200 mcg BIS 6 and 24 h after extubation. Control group received the same scheduled treatment as Group A, but the BIS was replaced with 2 ml normal saline. The patients were evaluated for sore throat and hoarseness 1, 24 and 48 h after extubation. The status of laryngopharynx was also recorded. There was no statistically significant difference in the incidence of sore throat among three groups. However, hoarseness occurred significantly less frequently in Group A (P < 0.05). One hour after extubation, Group A exhibited significantly less severe sore throat and hoarseness compared to the other two groups (P < 0.05), which disappeared 24 h later. The mucositis scores of laryngopharynx at 1, 24 and 48 h post-extubation were significantly lower in Group A (P < 0.05). BIS can reduce the incidence and severity of the POST prophylactically.
Department of Oto-Rhino-Laryngology Surgery, Ren Ji Hospistal, School of Medicine, Shanghai Jiao Tong University, Building 10, No. 1630, DongFang Road, 200127, Shanghai, China.
Yan-Qing
YQ
Chen
Ji-Ping
JP
Li
Jie
J
Xiao
D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D019819:Budesonide / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006685:Hoarseness / Q000517:prevention & control*; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D008875:Middle Aged; D010612:Pharyngitis / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D013961:Thyroid Gland / Q000601:surgery*; D016896:Treatment Outcome; D055815:Young Adult
D000893:Anti-Inflammatory Agents; D019819:Budesonide