Effect of hydrogel grafting, water and surfactant wetting on the adherence of PET wound dressings.
Traditional wound dressings, including cotton gauze, absorbent pads and bandages, can cause trauma and pain to wounds during dressing changes, leading to a variety of physical and psychosocial sequelae. The aim of this study was to adapt an in vitro model of adherence to evaluate the effects of various methods to theoretically reduce the adherence of wound dressings. Gelatin in liquid form was cast onto poly(ethylene terephthalate) (PET) fabric and allowed to solidify and progressively dry to simulate wound desiccation in the clinical setting. A 180° peel test of PET from the gelatin slab yielded adherence data of peeling energy. The peeling energy of PET increased with the drying time. It was possible to reduce the force by drying at 75% relative humidity (RH). After drying for 24h, either 500μL of water or surfactant solution was added onto the PET surface (16×60mm(2)). The peeling energy decreased dramatically with wetting and there was no significant difference between water and surfactant. As a long-term strategy for decreasing adherence, a thin layer of polyacrylamide (PAM) hydrogel was deposited onto PET fabric via UV irradiation. This resulted in a much lower peeling energy without severely compromising fabric flexibility. This hydrogel layer could also serve as a reservoir for bioactive and antimicrobial agents which could be sustainably released to create a microbe-free microenvironment for optimized wound healing.
Department of Textile Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, MB, Canada.
Chenxi Coco
CC
Ning
Manitoba Firefighters Burn Unit, Department of Surgery, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada.
Sarvesh
S
Logsetty
Department of Textile Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, MB, Canada.
Shivkumar
S
Ghughare
Department of Textile Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, MB, Canada; Department of Chemistry, University of Manitoba, Winnipeg, MB, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Department of Biosystems Engineering, University of Manitoba, Winnipeg, MB, Canada. Electronic address: Song.Liu@umanitoba.ca.
Song
S
Liu
D001458:Bandages; D002056:Burns / Q000628:therapy*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000627:therapeutic use*; D008954:Models, Biological; D011093:Polyethylene Terephthalates / Q000627:therapeutic use*; D013501:Surface-Active Agents / Q000627:therapeutic use*; D014867:Water
D011093:Polyethylene Terephthalates; D013501:Surface-Active Agents; D014867:Water; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate
Burn wound care dressing; Dressing adherence; Hydrogel grafting; In vitro dressing adherence test