N-heterocyclic carbene catalyzed activation of esters: a new option for asymmetric domino reactions.
Esters-what else! A new strategy in NHC organocatalysis allows the α-, β- and γ-activation of saturated and unsaturated esters. The resulting acyl azolium intermediates efficiently participate in domino reactions with suitable substrates to generate synthetically valuable carbo- and heterocycles with very good diastereo- and excellent enantioselectivities.
Institut für Organische Chemie, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany) http://www.oc.rwth_aachen.de/akenders/enders_d.html.
Pankaj
P
Chauhan
Dieter
D
Enders
N-heterocyclic carbenes; asymmetric synthesis; domino reactions; esters; organocatalysis