Obesity hypoventilation syndrome in obstructive sleep apnea patients in the United Arab Emirates: a retrospective cross-sectional study.
OBJECTIVE
To estimate the frequency of symptoms of obesity hypoventilation syndrome (OHS) in patients with obstructive sleep apnoea (OSA) and to evaluate comorbidities associated with OHS.


METHODS
Retrospective study based on patients' medical records and on further sleep tests performed in the study centre during the inclusion visit.


METHODS
Respiratory Care Unit and Sleep Disorder Centre of the Zayed Military Hospital United Arab Emirates.


METHODS
All patients referred to the study centre for a suspicion of sleep-disordered breathing.


METHODS
Prevalence of OSA and OSA + OHS and comorbidities in patients with OSA and OHS.


RESULTS
A total of 212 adult patients participated in the study. Of these, 107 patients (50.5% [43.8-57.1% CI 95%]) fulfilled diagnostic criteria for OSA, and the majority were men (79.4%). Among patients with OSA, 18 patients (16.8% [10.8-25.1% CI 95%]) fulfilled diagnostic criteria for OHS. In this group, women were more frequently affected than men (31.8% [7/22] vs. 12.9% [11/85], respectively; p = 0.03) and tended to be older than affected men, with a mean age of 55 ± 10.6 years versus 46 ± 13 for men. After adjustment for gender, OHS was significantly associated with hypertension (OR = 3.5; p = 0.03), diabetes mellitus (OR = 4.6; p = 0.02), ischaemic heart disease (OR = 5.1; p = 0.04) and pulmonary hypertension (OR = 16.1; p = 0.001).


CONCLUSIONS
OHS is a common condition in obese patients in the UAE and is associated with an increased risk of cardiovascular comorbidities and diabetes.
Respirology Division, Zayed Military Hospital, Abu Dhabi, UAE.
Ashraf
A
Alzaabi
Respirology Division, Zayed Military Hospital, Abu Dhabi, UAE.
Salahudeen
S
Fizal
Respirology Division, Zayed Military Hospital, Abu Dhabi, UAE.
Rafeek
R
Moilothkandy
Respirology Division, University of Sharjah, Sharjah, UAE.
Bassam
B
Mahboub
Faculty of Medicine and Health Sciences, UAE University. Al-Ain, UAE.
Nico
N
Nagelkerke
Pickwickian syndrome; hyperpnoea syndrome; obesity; obstructive lung disease; obstructive sleep apnoea; pulmonary hypertension; restrictive lung disease