Umbilical cord plasma and salivary insulin and leptin concentrations in AGA neonates: a preliminary report.
Background and objective: Insulin and leptin hormones are important regulators of food intake and energy balance. There is limited information about insulin and leptin hormones in neonates. This preliminary study aimed to investigate the concentrations of insulin and leptin in umbilical cord plasma and neonate's saliva and their relationships.


METHODS
Umbilical cord plasma and salivary samples were obtained from 13 healthy, appropriate for gestational age (AGA) neonates. Insulin and leptin concentrations in umbilical cord plasma and saliva were measured using the MILLIPLEX MAP® Human Metabolic Hormone Magnetic Bead Panel.


RESULTS
Insulin concentrations in umbilical cord plasma correlates positively and significantly with leptin concentrations in umbilical cord plasma (r = 0.55, p = 0.04).


CONCLUSIONS
More research is needed to explore the relationships between insulin and leptin hormones in neonate's saliva.
College of Nursing, University of Wisconsin-Milwaukee , Milwaukee, WI , USA .
Nuananong
N
Seal
Danish S
DS
Siddiqui
John
J
Seal
Kiley A
KA
Bernhard
Sumpan
S
Williams
D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D012463:Saliva / Q000737:chemistry
D007328:Insulin; D020738:Leptin
Insulin; leptin; neonates