A review on anti-inflammatory activity of phenylpropanoids found in essential oils.
The search for alternative drugs capable of disrupting the inflammatory process has become an important issue in scientific research, especially with reference to the use of natural substances and the reduction of undesirable side effects. Essential oils represent an important source of such substances, since their active constituents often exhibit an array of pharmacological properties, including anti-inflammatory activity. This review presents an overview of the anti-inflammatory action exerted by phenylpropanoids from essential oils and discusses possible mechanisms of action involved in the anti-inflammatory response, assessed through specific experimental models.
Departamento de Fisiologia e Patologia, Universidade Federal da Paraíba, CP 5009, João Pessoa CEP 58051-970, PB, Brazil.
Rita
R
de Cássia da Silveira E Sá
Departamento de Farmácia, Universidade Federal de Sergipe, São Cristóvão-SE, CEP 49100-000, SE, Brazil.
Luciana Nalone
LN
Andrade
Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, CP 5009, João Pessoa, CEP 58051-970, PB, Brazil.
Rafael
R
Dos Reis Barreto de Oliveira
Departamento de Fisiologia e Patologia, Universidade Federal da Paraíba, CP 5009, João Pessoa CEP 58051-970, PB, Brazil. sousadam@yahoo.com.
Damião Pergentino
DP
de Sousa
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy / Q000473:pathology; D001688:Biological Products / Q000008:administration & dosage / Q000737:chemistry*; D002934:Cinnamates / Q000737:chemistry; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000473:pathology; D056747:Immunomodulation / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy* / Q000276:immunology; D009822:Oils, Volatile / Q000008:administration & dosage / Q000737:chemistry*; D010649:Phenylalanine / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D001688:Biological Products; D002934:Cinnamates; D016207:Cytokines; D009822:Oils, Volatile; C029010:cinnamic acid; D010649:Phenylalanine