Cisplatin binds to human copper chaperone Cox17: the mechanistic implication of drug delivery to mitochondria.
Cox17 facilitates the platinum accumulation in mitochondria, which contributes to the overall cytotoxicity of cisplatin.
CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry & Collaborative Innovation Center of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei Anhui, 230026, China. liuyz@ustc.edu.cn.
Linhong
L
Zhao
Qinqin
Q
Cheng
Zhen
Z
Wang
Zhaoyong
Z
Xi
Dechen
D
Xu
Yangzhong
Y
Liu
D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism*; D002945:Cisplatin / Q000378:metabolism / Q000494:pharmacology*; D000079922:Copper Transport Proteins; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*
D000970:Antineoplastic Agents; C491006:COX17 protein, human; D002352:Carrier Proteins; D000079922:Copper Transport Proteins; D002945:Cisplatin