Inorganic polyphosphate adsorbed onto hydroxyapatite for guided bone regeneration: an animal study.
Inorganic polyphosphate (poly(P)) is recognized as a therapeutic agent that promotes fibroblast growth factor and enhances osteogenic differentiation, and in vivo, when adsorbed onto interconnected porous calcium hydroxyapatite (IP-CHA) enhances bone regeneration. The present study focused on the effect of poly(P) adsorbed onto IP-CHA granules (Poly(P)/IP-CHA) in guided bone regeneration (GBR). Dental implants were placed into the edentulous mandibular areas of five Beagle-Labrador hybrid dogs with screw expose on the buccal side, and then bone defects were filled Poly(P)/IP-CHA (test) or IP-CHA (control). After 12 weeks, histological evaluation and histomorphometrical analysis were performed. Newly-bone formation around exposed implant screw was clearly detected in the test-group. The ratio for regenerated bone height in the test group versus the control-group was 85.6±20.2 and 62.6±23.8, respectively, with no significant difference, while, that for bone implant contact was significantly higher (67.9±11.8 and 48.8±14.1, respectively). These findings indicate that Poly(P)/IP-CHA enhances bone regeneration in GBR.
Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical and Health Sciences.
Kazuya
K
Doi
Takayasu
T
Kubo
Ryou
R
Takeshita
Shiho
S
Kajihara
Shinichi
S
Kato
Yumi
Y
Kawazoe
Toshikazu
T
Shiba
Yasumasa
Y
Akagawa
D000327:Adsorption; D000818:Animals; D001861:Bone Regeneration; D004285:Dogs; D017886:Durapatite / Q000737:chemistry*; D007287:Inorganic Chemicals / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D011122:Polyphosphates / Q000737:chemistry*
D007287:Inorganic Chemicals; D011122:Polyphosphates; D017886:Durapatite