DNA-hybrid-gated multifunctional mesoporous silica nanocarriers for dual-targeted and microRNA-responsive controlled drug delivery.
The design of an ideal drug delivery system with targeted recognition and zero premature release, especially controlled and specific release that is triggered by an exclusive endogenous stimulus, is a great challenge. A traceable and aptamer-targeted drug nanocarrier has now been developed; the nanocarrier was obtained by capping mesoporous silica-coated quantum dots with a programmable DNA hybrid, and the drug release was controlled by microRNA. Once the nanocarriers had been delivered into HeLa cells by aptamer-mediated recognition and endocytosis, the overexpressed endogenous miR-21 served as an exclusive key to unlock the nanocarriers by competitive hybridization with the DNA hybrid, which led to a sustained lethality of the HeLa cells. If microRNA that is exclusively expressed in specific pathological cell was screened, a combination of chemotherapy and gene therapy should pave the way for a targeted and personalized treatment of human diseases.
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093 (P.R. China).
Penghui
P
Zhang
Fangfang
F
Cheng
Ri
R
Zhou
Juntao
J
Cao
Jingjing
J
Li
Clemens
C
Burda
Qianhao
Q
Min
Jun-Jie
JJ
Zhu
D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000378:metabolism*; D004317:Doxorubicin / Q000008:administration & dosage*; D006367:HeLa Cells; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D045663:Quantum Dots / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D052157:Aptamers, Nucleotide; D003692:Delayed-Action Preparations; D035683:MicroRNAs; D012822:Silicon Dioxide; D004317:Doxorubicin
DNA hybrids; drug delivery; mesoporous materials; microRNA; nanocarriers