Synthesis of proline-based N-heterocyclic carbene ligands.
The synthesis of proline-based N-heterocyclic carbene ligands is reported. An approach to a variety of proline-containing imidazolium NHC precursors is presented. The proline amino acids are shown to be compatible with peptide synthetic methods by incorporation into tripeptides. Following peptide synthesis, the carbene is generated and bound to rhodium.
Department of Chemistry, University of Houston , Houston, Texas 77204-5003, United States.
Yang
Y
Zhao
Scott R
SR
Gilbertson
D002384:Catalysis; D007093:Imidazoles / Q000737:chemistry; D008024:Ligands; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D007093:Imidazoles; D008024:Ligands; C030011:carbene; D011392:Proline; D012238:Rhodium; D008697:Methane