Verrucous carcinoma of the esophagus: a potential diagnostic dilemma.
Verrucous carcinoma of the esophagus is a rare variant of squamous cell carcinoma associated with human papillomavirus. We report the case of a 58-year-old female who presented with ongoing symptoms of dysphagia. On previous endoscopies she had been noted to have a large polyp-like mass involving the esophagus, with negative biopsies for malignancy. Repeat endoscopy with concurrent endoscopic ultrasound showed a large semi-pedunculated polyp in the distal esophagus and a hypoechoic, irregular mass involving the gastroesophageal junction with esophageal thickening. Deep layer biopsies showed pseudoepitheliomatous hyperplasia with immunohistochemical staining positive for human papillomavirus. The patient was subsequently treated with chemo-radiation followed by esophagectomy.
Internal Medicine, Sanford Medical Center, University of South Dakota, Sioux Falls, S. Dak., USA.
Kabir
K
Ahmed
Department of Surgery, Sanford Medical Center, University of South Dakota, Sioux Falls, S. Dak., USA.
Gary
G
Timmerman
Department of Gastroenterology, Sanford Medical Center, University of South Dakota, Sioux Falls, S. Dak., USA.
Robert
R
Meyer
Department of Pathology, Sanford Medical Center, University of South Dakota, Sioux Falls, S. Dak., USA.
Tara
T
Miller
Department of Medical Oncology, Sanford Medical Center, University of South Dakota, Sioux Falls, S. Dak., USA.
Miroslaw
M
Mazurczak
Department of Pathology, Sanford Medical Center, University of South Dakota, Sioux Falls, S. Dak., USA.
Kimberlee
K
Tams
Department of Gastroenterology, Sanford Medical Center, University of South Dakota, Sioux Falls, S. Dak., USA.
Muslim
M
Atiq
Esophagus; Human papillomavirus; Verrucous carcinoma