Watching the clock: endoplasmic reticulum-mediated control of circadian rhythms in cancer.
In the past 20 years both the circadian clock and endoplasmic reticulum (ER) stress signaling have emerged as major players in oncogenesis and cancer development. Although several lines of evidence have established functional links between these two molecular pathways, their interconnection and the subsequent functional implications in cancer development remain to be fully characterized. Herein, we provide an extensive review of the literature depicting the molecular connectivity linking ER stress signaling and the circadian clock and elaborate on the potential use of these functional interactions in cancer therapeutics.
Institut de Biologie de Lille, CNRS UMR8161/Universités Lille 1 et Lille 2/Institut Pasteur de Lille , 1, rue du Pr. Calmette, BP 447, 59021 Lille , France.
Olivier
O
Pluquet
Nicolas
N
Dejeans
Eric
E
Chevet
D000818:Animals; D057906:Circadian Clocks / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D015398:Signal Transduction / Q000502:physiology
ATF6; Angiogenesis; IRE1; PER1; PERK; cancer; circadian clock; endoplasmic reticulum; stress; tumor