Voltage-dependent properties of DNA origami nanopores.
We show DNA origami nanopores that respond to high voltages by a change in conformation on glass nanocapillaries. Our DNA origami nanopores are voltage sensitive as two distinct states are found as a function of the applied voltage. We suggest that the origin of these states is a mechanical distortion of the DNA origami. A simple model predicts the voltage dependence of the structural change. We show that our responsive DNA origami nanopores can be used to lower the frequency of DNA translocation by 1 order of magnitude.
Cavendish Laboratory, Department of Physics, University of Cambridge , JJ Thomson Avenue, Cambridge CB3 0HE, United Kingdom.
Silvia
S
Hernández-Ainsa
Karolis
K
Misiunas
Vivek V
VV
Thacker
Elisa A
EA
Hemmig
Ulrich F
UF
Keyser
D004247:DNA / Q000737:chemistry*; D055664:Electrochemical Techniques; D008956:Models, Chemical; D058608:Nanopores
D004247:DNA