[Clinical features and epidemiological trend of diabetic ketosis in patients admitted to West China Hospital].
OBJECTIVE
To evaluate the clinical features and epidemiological trend of diabetes ketosis (DK) in patients admitted to West China Hospital.


METHODS
We reviewed medical records of diabetic patients with DK who were admitted to West China Hospital from 1997 to 2005. Their clinical and laboratory data were analysed with SAS 9.0.


RESULTS
From 1997 to 2005, the proportion of diabetic patients with DK increased by 0.12% annually. The proportion of provoked DK patients (who had a clinically evident precipitating factor) in those with DK remained stable; whereas the proportion of T1D patients in those with DK declined by 2.00% annually and the proportion of ketosis prone obesity diabetes (KPD) in those with DK increased by 2.27% annually. The KPD patients displayed a striking male predominance (2.31:1, male:female) and were diagnosed at an older age compared with those with T1D [(46.3 +/- 12.9) yr. vs. (28.9 +/- 14.7) yr.]. The KPD patients were more likely to have a strong family history of diabetes and a better beta-cell function reserve, and be accompanied with dyslipidemia (52.7%), hypertension (23.3%), fatty liver (10.1%) and hyperuricemia/gout (8. 5%) compared with those with T1D.


CONCLUSIONS
In recent years the proportion of KPD patients in the hospitalized DK patients is increasing. With different characteristics compared with typical T1D, KPD might belong to a subgroup of T2D.
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Yun-Xia
YX
Zhou
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Hui-Wen
HW
Tan
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Ye-Rong
YR
Yu
D000293:Adolescent; D000328:Adult; D002681:China / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology; D016883:Diabetic Ketoacidosis / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D012189:Retrospective Studies; D012737:Sex Factors; D055815:Young Adult