Retroperitoneal Castleman's disease: advocating a multidisciplinary approach for a rare clinical entity.
BACKGROUND
Castleman's disease is a rare and poorly understood disease entity that may resemble more common conditions and represents a clinical challenge to the treating surgeon.


METHODS
In this report, we describe a case of a 61-year-old Caucasian woman with a symptomatic retroperitoneal mass. The specimen obtained from her resection contained a protuberant encapsulated mass, exhibiting microscopic features consistent with localized, unicentric Castleman's disease. These characteristics included architectural features and immunohistochemical findings consistent with the hyaline vascular variant of Castleman's disease.


CONCLUSIONS
We report a very rare case of a retroperitoneal hyaline vascular type of Castleman's disease. We discuss the diagnostic dilemma Castleman's disease may present to the surgeon, with an emphasis on multidisciplinary management of these patients. We also review current data on pathogenesis, treatment and outcomes.
Austin D
AD
Williams
Adriana
A
Sanchez
Jun Steve
JS
Hou
Rene Rothstein
RR
Rubin
Mark E
ME
Hysell
Blake D
BD
Babcock
Mohammad F
MF
Shaikh
Michael S
MS
Weingarten
Division of Surgical Oncology, Department of Surgery, Drexel University College of Medicine, 254 N, 15th St,, MS 413, Philadelphia, PA 19102, USA. wilbur.bowne@drexelmed.edu.
Wilbur B
WB
Bowne
D014408:Biomarkers, Tumor / Q000378:metabolism; D005871:Castleman Disease / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D011379:Prognosis; D012187:Retroperitoneal Space / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor