Analysis of association of TaqI VDR gene polymorphism with the chronic periodontitis in Dravidian ethnicity.
OBJECTIVE
The aim of this study is to analyze the association of TaqI vitamin D receptor (VDR) gene polymorphism with the chronic periodontitis (CP) in Dravidian ethnicity.


METHODS
A total of 120 subjects were recruited for this study, which included 60 CP and 60 healthy controls. TaqI VDR gene polymorphism was analyzed using specific primers and amplified by polymerase chain reaction (PCR) and visualized under 2% agarose gel.


RESULTS
Our study results showed that Tt and tt genotype had a higher frequency of occurrence in CP compared with controls. Similarly, t allele was found to be associated with CP.


CONCLUSIONS
Our study concludes that TaqI VDR gene polymorphism is associated with CP in Dravidian ethnicity.
Department of Periodontics, Saveetha Dental College, Chennai, Tamil Nadu, India.
Gurumoorthy
G
Kaarthikeyan
Department of Periodontics, Saveetha Dental College, Chennai, Tamil Nadu, India.
N D
ND
Jayakumar
Department of Periodontics, Saveetha Dental College, Chennai, Tamil Nadu, India.
O
O
Padmalatha
Department of Periodontics, Saveetha Dental College, Chennai, Tamil Nadu, India.
Sheeja
S
Varghese
Department of Genetics, ALMPGIBMS, Chennai, Tamil Nadu, India.
B
B
Anand
Alleles; TaqI; chronic periodontitis; polymorphism; vitamin D receptor