Implications of pentraxin 3 levels in patients with acute aortic dissection.
Acute aortic dissection (AAD) causes transient inflammation with occasional pleural fluid (PF) accumulation. Although pentraxin 3 (PTX3) is a vascular inflammation-related biomarker, little is known about PTX3 levels in patients with AAD. We explored the serial changes in plasma PTX3 levels and the association of peak levels with the amount of PF accumulation. Consecutive patients (n = 41) with Stanford type B AAD were enrolled, and blood samples for the measurements of serum albumin, plasma PTX3 and high-sensitivity C-reactive protein (CRP) were collected daily until 7 days after symptom onset. PF accumulation on computed tomography imaging on the third hospital day was divided into 3 grades (I: none or slight, II: mild in the uni- or bilateral pleural cavity, III: moderate or more). PTX3 and CRP levels were analyzed after logarithmic transformation because of their skewed distributions. Peak PTX3 and CRP levels were observed at 4.3 ± 2.1 and 4.7 ± 2.0 days after symptom onset, and their values were 12.2 [interquartile range (IQR), 8.2-20.9] ng/mL and 12.0 (IQR, 8.6-15.2) mg/dL, respectively. On univariate analysis, the peak level of PTX3 had a negative correlation with the minimum level of serum albumin, and a positive correlation with PF grade and duration of intensive care unit stay. On multivariate analysis, the peak level of PTX3 was correlated with PF grade (P = 0.037). In conclusion, the peak level of PTX3 in patients with AAD was associated with the amount of transient PF accumulation, which may be associated with inflammatory vascular permeability.
Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma, Omiya-ku, Saitama, 330-8503, Japan, araon@omiya.jichi.ac.jp.
Kenshiro
K
Arao
Takayuki
T
Fujiwara
Yousuke
Y
Taniguchi
Hiroyuki
H
Jinnouchi
Harue
H
Sasai
Mitsunari
M
Matsumoto
Hiroshi
H
Funayama
Junya
J
Ako
Shin-ichi
S
Momomura
D000208:Acute Disease; D000368:Aged; D000784:Aortic Dissection / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D001014:Aortic Aneurysm / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D001027:Aortography / Q000379:methods; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D002199:Capillary Permeability; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010996:Pleural Effusion / Q000097:blood / Q000175:diagnosis; D011237:Predictive Value of Tests; D011379:Prognosis; D012709:Serum Albumin / Q000378:metabolism; D000075462:Serum Albumin, Human; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D000099153:Pentraxins
D015415:Biomarkers; D002097:C-Reactive Protein; D018836:Inflammation Mediators; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D000683:Serum Amyloid P-Component; D000099153:Pentraxins; C422455:ALB protein, human