Tablet disintegration studied by high-resolution real-time magnetic resonance imaging.
The present work employs recent advances in high-resolution real-time magnetic resonance imaging (MRI) to investigate the disintegration process of tablets containing disintegrants. A temporal resolution of 75 ms and a spatial resolution of 80 × 80 µm with a section thickness of only 600 µm were achieved. The histograms of MRI videos were quantitatively analyzed with MATLAB. The mechanisms of action of six commercially available disintegrants, the influence of relative tablet density, and the impact of disintegrant concentration were examined. Crospovidone seems to be the only disintegrant acting by a shape memory effect, whereas the others mainly swell. A higher relative density of tablets containing croscarmellose sodium leads to a more even distribution of water within the tablet matrix but hardly impacts the disintegration kinetics. Increasing the polacrilin potassium disintegrant concentration leads to a quicker and more thorough disintegration process. Real-time MRI emerges as valuable tool to visualize and investigate the process of tablet disintegration.
Julian
J
Quodbach
Amir
A
Moussavi
Roland
R
Tammer
Jens
J
Frahm
Peter
P
Kleinebudde
D002266:Carboxymethylcellulose Sodium / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D007700:Kinetics; D008279:Magnetic Resonance Imaging / Q000379:methods; D011205:Povidone / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D013607:Tablets; D014867:Water; D011205:Povidone; D002266:Carboxymethylcellulose Sodium