Serum Follistatin-like-3 was elevated in second trimester of pregnant women who subsequently developed preeclampsia.
OBJECTIVE
To determine whether serum Follistatin-like-3 was enhanced in second trimester of pregnant women who subsequently developed preeclampsia.


METHODS
Thirty-nine pregnant women subsequently developed preeclampsia and 73 normal pregnancy women were included. Serum samples taken in 24-28 weeks gestation were used for assay of Follistatin-like-3.


RESULTS
Follistatin-like-3 was significantly elevated in preeclampsia group compared with control. However, there was no significant difference of Follistatin-like-3 in women with mild or severe preeclampsia.


CONCLUSIONS
The elevation of Follistatin-like-3 was demonstrated in late second trimester of pregnancy destined to developing preeclampsia, suggesting its causal role in the pathogenesis and prediction of preeclampsia.
Obstetric Department, Women's Hospital, School of Medicine, Zhejiang University , Zhejiang Province , China.
Xiujun
X
Han
Jing
J
He
Aiping
A
Wang
Minyue
M
Dong
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D038702:Follistatin-Related Proteins / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood*; D012307:Risk Factors; D012720:Severity of Illness Index
D015415:Biomarkers; D038702:Follistatin-Related Proteins
Follistatin-like-3; Prediction; Preeclampsia; Pregnancy; Second trimester.