The role of key genes and pathways involved in the tumorigenesis of Malignant Mesothelioma.
Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes (p16(INK4a), p14(ARF), NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM.
Laboratory of Hypertension, Campus Universitário Morro do Cruzeiro, Brazil; Pharmacy School, Federal University of Ouro Preto, Minas Gerais, Brazil.
Leonardo Vinícius Monteiro
LV
de Assis
Laboratory of Hypertension, Campus Universitário Morro do Cruzeiro, Brazil; Núcleo de Pesquisa em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil.
Jamille
J
Locatelli
Department of Biological Science, Institute of Exact and Biological Sciences, Brazil; Laboratory of Hypertension, Campus Universitário Morro do Cruzeiro, Brazil; Núcleo de Pesquisa em Ciências Biológicas (NUPEB), Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil. Electronic address: mauroisoldi@hotmail.com.
Mauro César
MC
Isoldi
D001194:Asbestos / Q000633:toxicity; D063646:Carcinogenesis / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000473:pathology; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008654:Mesothelioma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D000086002:Mesothelioma, Malignant; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*; D013539:Simian virus 40 / Q000472:pathogenicity; D017641:Zeolites / Q000633:toxicity
D001194:Asbestos; D019869:Phosphatidylinositol 3-Kinases; D017641:Zeolites; C083174:erionite
Erionite/SV40; Genes and pathways; Malignant Mesothelioma; NF2; PI3K/AKT; p16(INK4a)/p(14ARF)