Aspewentins A-C, norditerpenes from a cryptic pathway in an algicolous strain of Aspergillus wentii.
Through addition of suberoylanilide hydroxamic acid, two new aromatic norditerpenes, aspewentins A (1) and B (2), along with an oxygenated derivative, aspewentin C (3), were obtained from the culture of an Aspergillus wentii strain (na-3) isolated from the tissue of the brown alga Sargassum fusiforme. The structures and absolute configurations were unambiguously elucidated by spectroscopic analyses and quantum chemical calculations. Aspewentins A-C were produced before sporulation and exhibited potent bioactivities against some marine-derived organisms.
Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences , Yantai 264003, People's Republic of China.
Feng-Ping
FP
Miao
Xiao-Rui
XR
Liang
Xiang-Hong
XH
Liu
Nai-Yun
NY
Ji
D001230:Aspergillus / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D004578:Electron Spin Resonance Spectroscopy; D006877:Hydroxamic Acids / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D044647:Sargassum / Q000382:microbiology; D000077337:Vorinostat
D004224:Diterpenes; D006877:Hydroxamic Acids; C000590248:aspewentin A; C000590249:aspewentin B; C000590250:aspewentin C; D000077337:Vorinostat