Association of serum IgG4 and soluble interleukin-2 receptor levels with epicardial adipose tissue and coronary artery calcification.
OBJECTIVE
Immunoglobulin G4 (IgG4)-related immuno-inflammation may play a role in the development of coronary artery disease (CAD). We analyzed the association of serum IgG4 and soluble interleukin-2 receptor (sIL-2R) levels with epicardial fat volume (EFV) and coronary artery calcification (CAC).


METHODS
Serum IgG4 and sIL-2R levels were measured in 267 patients who underwent 320-slice cardiac computed tomography.


RESULTS
THE median serum levels of IgG4 and sIL-2R were higher in patients with CAD than in those without. Serum IgG4 levels were significantly greater in patients with EFV within the second and fourth quartile (≥75 mL) than in those with low EFV (b75 mL) (33.5 mg/dL vs. 22.5 mg/dL). On the other hand, serum sIL-2R levels were significantly higher in patients with CAC than in those without (409 U/mL vs. 345 U/mL). In age- and gender-adjusted logistic regression analysis, the fourth quartile of IgG4 (≥56.7 mg/dL) was associated with EFV within the second and fourth quartile (≥75 mL) with an odds ratio of 3.13.


CONCLUSIONS
Serum IgG4 levels were greater in patients with EFV within the second and fourth quartile, whereas serum sIL-2R levels were increased in patients with CAC. These two biomarkers may reflect different mechanisms underlying development of cardiovascular remodeling.
Aiko
A
Sakamoto
Nobukazu
N
Ishizaka
Yasushi
Y
Imai
Jiro
J
Ando
Ryozo
R
Nagai
Issei
I
Komuro
D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000097:blood* / Q000378:metabolism; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007249:Inflammation / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000097:blood* / Q000378:metabolism; D012995:Solubility; D055815:Young Adult
D007074:Immunoglobulin G; D015375:Receptors, Interleukin-2