Comprehensive screening of veterinary drugs in honey by ultra-high-performance liquid chromatography coupled to mass spectrometry.
In the context of multi-residue screening in honey, a complete methodology was developed for 200 veterinary drugs comprising a sample preparation step and an ultra-high-performance liquid chromatography (UHPLC) coupled to time-of-flight (TOF) mass spectrometry analysis. In addition, specific analytical strategies were developed for two compounds, streptomycin and chloramphenicol, using UHPLC and tandem mass spectrometry (MS/MS). Methodologies were then applied to real honey samples obtained from the Swiss market.
a Official Food Control Authority and Veterinary Affairs of Geneva , 22 Quai Ernest-Ansermet, 1211 Geneva 4, Switzerland.
Aline
A
Staub Spörri
Philippe
P
Jan
Emmanuelle
E
Cognard
Didier
D
Ortelli
Patrick
P
Edder
D053000:Analytic Sample Preparation Methods; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry; D002701:Chloramphenicol / Q000032:analysis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis* / Q000737:chemistry / Q000592:standards; D005062:European Union; D005506:Food Contamination; D005513:Food Inspection / Q000379:methods*; D019983:Guideline Adherence; D017408:Guidelines as Topic; D006722:Honey / Q000032:analysis* / Q000191:economics / Q000592:standards; D057230:Limit of Detection; D010573:Pesticide Residues / Q000032:analysis / Q000737:chemistry / Q000592:standards; D015203:Reproducibility of Results; D052616:Solid Phase Extraction; D021241:Spectrometry, Mass, Electrospray Ionization; D013307:Streptomycin / Q000032:analysis / Q000737:chemistry; D013557:Switzerland; D053719:Tandem Mass Spectrometry; D019155:Veterinary Drugs / Q000032:analysis* / Q000737:chemistry / Q000592:standards
D000900:Anti-Bacterial Agents; D010573:Pesticide Residues; D019155:Veterinary Drugs; D002701:Chloramphenicol; D013307:Streptomycin
honey; liquid chromatography; mass spectrometry; screening; veterinary drugs