Influenza vaccines: unmet needs and recent developments.
Influenza is a worldwide public health concern. Since the introduction of trivalent influenza vaccine in 1978, vaccination has been the primary means of prevention and control of influenza. Current influenza vaccines have moderate efficacy, good safety, and acceptable tolerability; however, they have unsatisfactory efficacy in older adults, are dependent on egg supply for production, and are time-consuming to manufacture. This review outlines the unmet medical needs of current influenza vaccines. Recent developments in influenza vaccines are also described.
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ; Asian Pacific Influenza Institute, Korea University College of Medicine, Seoul, Korea.
Ji Yun
JY
Noh
Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea. ; Asian Pacific Influenza Institute, Korea University College of Medicine, Seoul, Korea. ; Transgovernmental Enterprise for Pandemic Influenza in Korea, Seoul, Korea.
Woo Joo
WJ
Kim
Influenza Vaccines; Influenza, Human; Pandemics