Interplay between microRNAs and host pathogen recognition receptors (PRRs) signaling pathways in response to viral infection.
Antimicrobial response is greatly influenced by microRNAs (miRNAs) which are the important post-transcriptional regulators of gene expression. Simultaneously, host pathogen recognition receptors (PRRs) engaged by pathogen-associated molecular patterns (PAMPs) also play critical roles in activating innate immunity against microbial infection. Emerging evidences suggest that the interaction between microbial-regulated miRNAs and important PRRs signaling pathways influence host immune response to microbial pathogens. In this manuscript, we describe the roles of miRNAs in virus-regulated innate immune pathways and the crosstalk between miRNAs and PRRs, further breaking out the mechanistic dissection of miRNAs-PRRs in viral infection and the development of the prognosis of disease and novel miRNA-therapeutic strategies targeting immunity.
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
Ao
A
Zhou
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
Shuaifeng
S
Li
Hubei Key Laboratory of Animal Embryo and Molecular Breeding, Institute of Animal Husbandry and Veterinary, Hubei Provincial Academy of Agricultural Sciences, Wuhan 430064, China.
Junjing
J
Wu
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
Faheem Ahmed
FA
Khan
Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: sjxiaozhang@mail.hzau.edu.cn.
Shujun
S
Zhang
D053263:Gene Regulatory Networks; D054884:Host-Pathogen Interactions; D007113:Immunity, Innate; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction; D014780:Viruses / Q000254:growth & development / Q000276:immunology*
D035683:MicroRNAs; D051192:Receptors, Pattern Recognition
Innate immune response; MicroRNAs; PAMP; PRRs