Transfusion related anaphylaxis during orthotopic liver transplantation.
Acute non-hemolytic transfusion reactions, consisting of both allergic and febrile reactions, are common occurring in up to 10.2% of transfused blood products, however anaphylaxis, or severe allergic reactions, are rare following transfusion. The incidence of anaphylaxis is more common after the transfusion of plasma containing products with estimations from 1:10,000-33,000 units of platelets and 1:29,000-50,000 units of fresh frozen plasma (FFP) compared with 1:50,000-200,000 units of red blood cells. Despite the rare occurrence, the clinical significance of transfusion related anaphylaxis can be severe with 12 reported fatalities over a 5-year span. We report a case of FFP related anaphylaxis in a patient anticipating orthotopic liver transplant (OLT) with a unique peri-operative treatment plan.
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
Allison
A
Paroskie
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address: garrett.s.booth@vanderbilt.edu.
Garrett S
GS
Booth
D000707:Anaphylaxis / Q000209:etiology* / Q000628:therapy; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D010949:Plasma