Glycogen phosphorylase isoenzyme BB, creatine kinase isoenzyme MB and troponin I for monitoring patients with percutaneous coronary intervention - a pilot study.
OBJECTIVE
The glycogen phosphorylase isoenzyme BB (GPBB), as an ischemic marker, has not yet been investigated after elective percutaneous coronary intervention (PCI). ose aim of the study was to monitor GPBB, creatine kinase myocardial isoform (CK-MB) mass) and troponin I (TnI) value after PCI in correlation with ischemic incidents.


METHODS
Forty-two consecutive patients undergoing elective PCI were included in the study. Baseline blood samples and two more after the PCI (3 and 24 hours) were taken. The significance of cardiac markers in twenty-ththe stable patients with baseline values of CK-MB mass and TnI below the upper reference limit (URL) was evaluated based on ischemic incidents after PCI.


RESULTS
TnI value was the only biomarker that was statistically significant at 3 and 24 hours after PCI in group of 23 stable patients. An overall comparisonthe biomarkers of 18 patients without and five patients with ischemic incidents displayed significant differences only for the baseline GPBB (p=0.019) and CK-MB mass 24 hours after PCI (p=0.034). Ischemic incidents were independently predictable only based on overall CK-MB mass measurements (OR=1.680, p=0.041) and particularly GPBB at baseline (OR=1.899, p=0.008) and CK-MB mass 24 hours after PCI (OR=2.111, p=0.022).


CONCLUSIONS
Only significant increases in TnI were observed after elective PCI with ischemic incidents predicted using GPBB and CK-MB mass measurements.
Institute of Clinical Chemistry and Biochemistry, 2Department for Cardiology; University Medical Centre Ljubljana, Slovenia.
Milan
M
Skitek
Igor
I
Kranjec
Aleš
A
Jerin
D000368:Aged; D052279:Creatine Kinase, MB Form / Q000097:blood*; D005260:Female; D024981:Glycogen Phosphorylase / Q000097:blood*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008991:Monitoring, Physiologic; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis; D062645:Percutaneous Coronary Intervention; D010865:Pilot Projects; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis; D011446:Prospective Studies; D019210:Troponin I / Q000097:blood*
D007527:Isoenzymes; D019210:Troponin I; D024981:Glycogen Phosphorylase; C528446:glycogen phosphorylase BB, human; D052279:Creatine Kinase, MB Form