Antifungal ether diglycosides from Matayba guianensis Aublet.
Since the 1960s, fungal infections have become a major worldwide public health problem. Antifungal treatments have many limitations, such as toxicity and resistance. Matayba guianensis Aublet (Sapindaceae) was chemically investigated as part of our ongoing search for lead molecules against fungi in the Brazilian Cerrado biome. The ethanolic extract of M. guianensis root bark revealed the presence of two previously unreported ether diglycosides: matayoside E (1) and F (2) with anti Candida activity, along with two known compounds: cupanioside (3) and stigmasterol (4).
Laboratório de Farmacognosia, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900 Brasília, DF, Brazil.
Polyana A
PA
de Assis
Laboratório de Farmacognosia, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900 Brasília, DF, Brazil.
Phellipe N E T
PN
Theodoro
Laboratório de Anatomia Vegetal, Universidade de Brasília, Brasília, Brazil.
José E
JE
de Paula
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Brazil.
Ana J
AJ
Araújo
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Brazil.
Letícia V
LV
Costa-Lotufo
Laboratoire de Pharmacognosie, U.M.R./C.N.R.S. 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.
Sylvie
S
Michel
Laboratoire de Pharmacognosie, U.M.R./C.N.R.S. 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France.
Raphaël
R
Grougnet
Laboratoire de Pharmacognosie, U.M.R./C.N.R.S. 8638, Faculté des Sciences Pharmaceutiques et Biologiques, Université Paris Descartes, Sorbonne Paris Cité, 4 Avenue de l'Observatoire, 75006 Paris, France. Electronic address: marina.kritsanida@parisdescartes.fr.
Marina
M
Kritsanida
Laboratório de Farmacognosia, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900 Brasília, DF, Brazil. Electronic address: darvenne@unb.br.
Laila S
LS
Espindola
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002175:Candida / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D024301:Plant Bark / Q000737:chemistry / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry / Q000378:metabolism; D029631:Sapindaceae / Q000737:chemistry* / Q000378:metabolism
D000935:Antifungal Agents; D006027:Glycosides
Antifungal activity; Brazilian Cerrado; Ether diglycosides; Matayba guianensis; Matayosides E and F