Novel avian-origin influenza A (H7N9) virus attachment to the respiratory tract of five animal models.
We determined the pattern of attachment of the avian-origin H7N9 influenza viruses A/Anhui/1/2013 and A/Shanghai/1/2013 to the respiratory tract in ferrets, macaques, mice, pigs, and guinea pigs and compared it to that in humans. The H7N9 attachment pattern in macaques, mice, and to a lesser extent pigs and guinea pigs resembled that in humans more closely than the attachment pattern in ferrets. This information contributes to our knowledge of the different animal models for influenza.
Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands.
Jurre Y
JY
Siegers
Kirsty R
KR
Short
Lonneke M E
LM
Leijten
Miranda
M
de Graaf
Monique I J
MI
Spronken
Eefje J A
EJ
Schrauwen
Nicolle
N
Marshall
Anice C
AC
Lowen
Gülsah
G
Gabriel
Albert D M E
AD
Osterhaus
Thijs
T
Kuiken
Debby
D
van Riel
D000818:Animals; D002681:China; D004195:Disease Models, Animal; D005260:Female; D005289:Ferrets; D006168:Guinea Pigs; D006801:Humans; D064766:Influenza A Virus, H7N9 Subtype / Q000235:genetics / Q000502:physiology*; D007251:Influenza, Human / Q000821:virology*; D008251:Macaca; D008297:Male; D051379:Mice; D012137:Respiratory System / Q000821:virology*; D013552:Swine; D053585:Virus Attachment