Stability studies of cefpirome sulfate in the solid state: Identification of degradation products.
The process of degradation was studied by using an HPLC-DAD method. Four degradation products were identified with a hybrid ESI-Q-TOF mass spectrometer. The influence of temperature and relative air humidity (RH) on the stability of cefpirome sulfate was investigated. In the solid state the degradation of cefpirome sulfate was a first-order reaction depending on the substrate concentration. The kinetic and thermodynamic parameters of degradation were calculated.
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland. Electronic address: pzalewski@ump.edu.pl.
Przemysław
P
Zalewski
Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
Robert
R
Skibiński
Department of Pharmaceutical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
Judyta
J
Cielecka-Piontek
D002511:Cephalosporins / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D006813:Humidity; D007700:Kinetics; D013058:Mass Spectrometry / Q000379:methods; D013696:Temperature; D013816:Thermodynamics; D000097572:Cefpirome
D002511:Cephalosporins; D000097572:Cefpirome
Cefpirome sulfate; HPLC; Q-TOF; Stability in solid state; thermodynamical parameters