Design and evaluation of polysaccharide-based transdermal films for the controlled delivery of nifedipine.
It was aimed to develop the matrix type polysaccharide-based transdermal films of nifedipine (NFD) to provide its long term plasma concentration. The mechanical tests were carried out on gel formulations which were utilised in the fabrication of transdermal films to determine the type of polymer (pectin, sodium alginate) and plasticizer (propylene glycol, glycerine) as well as their concentrations. The mechanical strength, elasticity, bioadhesiveness and the drug release characteristics of optimised films containing NFD were evaluated. Permeation of NFD from the films with/without adding an enhancer (nerolidol) was followed through excised rat skin using Franz diffusion cells. Results showed that the gels composed of either pectin or sodium alginate were appropriate for the fabrication of transdermal films of NFD, and the addition of propylene glycol improved mechanical strength, flexibility, and bioadhesiveness of the films. Permeation data showed that nerolidol was an effective permeation enhancer for the polysaccharide-based transdermal films of NFD.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Istanbul University.
Ayşegül
A
Bektaş
Erdal
E
Cevher
Sevgi
S
Güngör
Yıldız
Y
Ozsoy
D000268:Adhesiveness; D000279:Administration, Cutaneous; D000464:Alginates / Q000737:chemistry*; D000818:Animals; D002121:Calcium Channel Blockers / Q000008:administration & dosage* / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004548:Elasticity; D005260:Female; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D009543:Nifedipine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010368:Pectins / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000737:chemistry; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D057968:Transdermal Patch; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics
D000464:Alginates; D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D012717:Sesquiterpenes; D014665:Vasodilator Agents; D010368:Pectins; D020723:Glucuronic Acid; D009543:Nifedipine; C037055:nerolidol