An approach for the delineation of a generic cut-off value for local respiratory tract irritation by irritating or corrosive substances as a pragmatic tool to fulfill REACH requirements.
Under the current European legislation for the Registration, Evaluation, Authorisation and restriction of Chemicals (REACHs) a Derived No Effect Level (DNEL) has to be delineated for acute and chronic inhalation effects. The majority of available experimental studies are performed by the oral route of exposure. Route to route extrapolation poses particular problems for irritating or corrosive substances but the necessity for additional animal studies with inhalation exposure needs to be balanced with the regulatory information requirements. Existing occupational exposure limits (OEL) as surrogate for cut-off limits representing safe exposure under working conditions were grouped under certain criteria for substances that are legally classified in Europe as irritating or corrosive. As a result, it was shown that the OEL for irritating substances in this dataset is not lower than 10mg/m(3) and for corrosives not lower than 1mg/m(3). Under certain conditions these generic limits could be applied as a pragmatic, but still sufficiently reliable and protective upper cut-off limit approach to avoid additional animal tests with irritating or corrosive chemicals. The respective systemic toxicity profiles and physical-chemical properties need to be considered. Specific exclusion criteria for the discussed concept apply.
Bioresco Food Scientific and Regulatory Services, Jülicherstr. 369, 52070 Aachen, Germany. Electronic address: hmessing@arcor.de.
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Messinger
D000818:Animals; D002424:Caustics / Q000592:standards* / Q000633:toxicity*; D005062:European Union; D033161:Government Regulation; D006801:Humans; D019570:Inhalation Exposure / Q000592:standards*; D007509:Irritants / Q000592:standards* / Q000633:toxicity*; D016273:Occupational Exposure / Q000592:standards; D012137:Respiratory System / Q000187:drug effects; D018570:Risk Assessment / Q000331:legislation & jurisprudence / Q000379:methods; D020711:Threshold Limit Values
D002424:Caustics; D007509:Irritants
Corrosion; Cut-off limit; DNEL; Inhalation; Irritation; REACH