Smart magnetic poly(N-isopropylacrylamide) to control the release of bio-active molecules.
Thermo switchable magnetic hydrogels undoubtedly have a great potential for medical applications since they can behave as smart carriers able to transport bioactive molecules to a chosen part of the body and release them on demand via magneto-thermal activation. We report on the ability to modify the lower critical solution temperature (LCST) of poly(N-isopropylacrylamide) (PNIPAM) on demand from 32 °C to LCST ≥ 37 °C. This was achieved by the absorption of controlled amounts of magnetite nanoparticles on the polymer chains. We show, through the effect on cell viability, that the resulting magnetic PNIPAM is able to trap and to release bio-active molecules, such as cell growth factors. The activities of the released bio molecule are tested on human umbilical vein endothelial cells culture. We demonstrate that the LCST of the magnetic PNIPAM can be reached remotely via inductive heating with an alternating magnetic field. This approach on magnetic PNIPAM clearly supports appealing applications in safe biomedicine.
Consiglio Nazionale Delle Ricerche - Istituto per lo Studio dei Materiali Nanostrutturati (CNR-ISMN), via P. Gobetti 101, 40129, Bologna, Italy, c.dionigi@bo.ismn.cnr.it.
Chiara
C
Dionigi
Lisa
L
Lungaro
Vitaly
V
Goranov
Alberto
A
Riminucci
Yolanda
Y
Piñeiro-Redondo
Manuel
M
Bañobre-López
José
J
Rivas
Valentin
V
Dediu
D000180:Acrylic Resins / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008280:Magnetics; D008422:Materials Testing; D013818:Thermogravimetry; D042461:Vascular Endothelial Growth Factor A / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D042461:Vascular Endothelial Growth Factor A; C052970:poly-N-isopropylacrylamide