[Real world study of affect on liver function of overdose of salvianolate extract injection].
OBJECTIVE
To understand the affect on liver function of using salvianolate injection above the recommended dose.


METHODS
Nationwide, research of hospital information system (HIS) data from 18 general hospitals comprising 14 191 patients was carried out. Two groups of patients were studied and their blood tests monitored before and after injections. One group received the recommended dose of 200 mg, the other exceeded it. To take into account group differences the propensity score method and logstic regression was used alongside liver function.


RESULTS
When salvianolate injection was administered above the recommended dose patients were more likely to have abnormal AST and ALT levels. However, the difference between the groups was not statistically significant.


CONCLUSIONS
According to our data the affect of exceeding the recommended dose of salvianolate injection on liver function is not significant. However, monitoring of liver function should be carried out in clinic.
Institute of Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. cyp2668@163.com
Yan-Peng
YP
Chang
Renmin University of China, Beijing 100872, China.
Jian
J
Huo
Institute of Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yan-Ming
YM
Xie
Renmin University of China, Beijing 100872, China.
Hui
H
Zhang
The PLA Navy General Hospital, Beijing 100048, China.
Yan
Y
Zhuang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006751:Hospital Information Systems / Q000706:statistics & numerical data; D006801:Humans; D007263:Infusions, Parenteral; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects; D064792:Pragmatic Clinical Trials as Topic; D057216:Propensity Score; D055815:Young Adult
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C561960:salvianolate; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase