Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.
A library of potentially bioactive compounds through the novel 1H-indole-methyl-isocyanide and MCRs has been described. A flexible and efficient synthesis affording great complexity and diversity is achieved with moderate to good yields with no need for protection and deprotection steps.
Department of Drug Design, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands. a.s.s.domling@rug.nl.
Constantinos G
CG
Neochoritis
Alexander
A
Dömling
D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
D007211:Indoles