Exercise test in pediatric renal transplant recipients and its relationship with their cardiac function.
Pediatric kidney transplant recipients are at increased risk of CVD. Exercise test is a good method to evaluate exercise capacity, cardiorespiratory fitness, and risk of potential CVDs. The aim of this study was to assess the exercise capacity in this population and determine its relationship with their cardiac function using conventional and tissue Doppler echocardiography. Exercise test, conventional and tissue Doppler echocardiography were performed on 44 kidney transplant children (age ranging 11-20, 59% male) with acceptable renal function, and the results were compared with their normal healthy counterparts. Our transplant patients achieved significantly lower maximal heart rate, maximal heart rate ratio, total energy expenditure during the exercise, and maximal O2 consumption (Max VO2 ) than the normal group (p < 0.05). No correlation was found between hemoglobin (Hb) level, dialysis duration, kidney function, and the exercise test parameters. Kidney transplant patients had preserved systolic despite diminished diastolic cardiac function compared to the normal children. Our pediatric renal transplant recipients had severely impaired diastolic dysfunction and significantly reduced MaxVO2 compared with their healthy counterparts. No correlation was found between MaxVO2 and measured indices of systolic and diastolic cardiac function.
Medical School, Shiraz Nephrology-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Ali
A
Derakhshan
Dorna
D
Derakhshan
Hamid
H
Amoozgar
Mohammad Ali
MA
Shakiba
Mitra
M
Basiratnia
Mohammad Hossein
MH
Fallahzadeh
D000293:Adolescent; D002318:Cardiovascular Diseases / Q000150:complications* / Q000628:therapy; D002648:Child; D003430:Cross-Sectional Studies; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005080:Exercise Test; D005260:Female; D006334:Heart Function Tests; D006339:Heart Rate; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D010101:Oxygen Consumption; D051437:Renal Insufficiency / Q000150:complications* / Q000628:therapy; D012306:Risk; D013997:Time Factors; D066027:Transplant Recipients; D016896:Treatment Outcome; D055815:Young Adult
Exercise test; cardiac function; children; echocardiography; pediatric kidney transplantation