[New developments in the antiarrhythmic therapy of atrial fibrillation].
Atrial fibrillation often affects elderly people with cardiovascular disease and takes a progressive course with increasing resistance to treatment. For the latter, electrical and structural changes (remodelling) seem to be responsible that are directly related to the high excitatory rate in the atria. Therapeutic strategies for atrial fibrillation consist of (i) treating the underlying cardiovascular disease, (ii) re-establishing sinus rhythm and (iii) reducing ventricular rate. Rapid pharmacological or electrical cardioversion is expected to prevent remodelling. Classical antiarrhythmic drugs are notoriously ineffective and burdened with serious cardiac and extracardiac side effects so that there is an urgent need for effective and safe novel compounds. In this review the three recently introduced drugs dronedarone, vernakalant and ranolazine are discussed with respect to the use in atrial fibrillation. Other new antiarrhythmic agents are still in the developmental phase and aim at atria-selective mechanisms thereby excluding ventricular proarrhythmic effects. The mechanisms of action will be discussed in the context of the present understanding of the pathophysiology of onset and maintenance of atrial fibrillation.
Medizinische Fakultät Carl Gustav Carus, Institut für Pharmakologie und Toxikologie, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland, ravens@rcs.urz.tu-dresden.de.
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D000083:Acetanilides / Q000008:administration & dosage*; D000638:Amiodarone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000840:Anisoles / Q000008:administration & dosage*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage* / Q000145:classification; D001281:Atrial Fibrillation / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D000077764:Dronedarone; D004359:Drug Therapy, Combination / Q000379:methods; D019317:Evidence-Based Medicine; D006801:Humans; D010879:Piperazines / Q000008:administration & dosage*; D011759:Pyrrolidines / Q000008:administration & dosage*; D000069458:Ranolazine; D026941:Sodium Channel Blockers / Q000008:administration & dosage*; D016896:Treatment Outcome
D000083:Acetanilides; D000840:Anisoles; D000889:Anti-Arrhythmia Agents; D010879:Piperazines; D011759:Pyrrolidines; D026941:Sodium Channel Blockers; C524581:vernakalant; D000069458:Ranolazine; D000077764:Dronedarone; D000638:Amiodarone