NHCs catalyzed hydrophosphonylation of α-ketoesters and α-trifluoromethyl ketones.
N-Heterocyclic carbenes catalyzed hydrophosphonylation reaction of α-ketoesters and α-trifluoromethyl ketones was developed. Under the catalysis of 10 mol% IPr, α-ketoesters or α-trifluoromethyl ketones reacted with dialkyl phosphites to provide quaternary α-hydroxyphosphonates in good to excellent yield.
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang 832000, China.
Lin
L
He
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang 832000, China.
Zhi-Hua
ZH
Cai
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang 832000, China.
Ji-Xin
JX
Pian
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan and School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang 832000, China.
Guang-Fen
GF
Du
D002384:Catalysis; D004952:Esters / Q000378:metabolism*; D007659:Ketones / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D010766:Phosphorylation; D021241:Spectrometry, Mass, Electrospray Ionization
D004952:Esters; D007659:Ketones