A uterine tumor resembling ovarian sex cord tumor associated with tamoxifen treatment: a case report and literature review.
Uterine tumors resembling ovarian sex cord tumors are rare neoplasms of unknown etiology that are classified as distinct from endometrial stromal tumors on the basis of their morphologic, molecular, and behavioral characteristics. These neoplasms have a variable immunophenotype, sometimes coexpressing epithelial, myoid, and sex cord markers. To date, only 2 cases of uterine tumors resembling ovarian sex cord tumors associated with tamoxifen use have been reported. Here, we report the case of a 49-year-old woman who had been using tamoxifen for 5 years to treat breast cancer. The tumor was initially diagnosed by hysteroscopy biopsy on the basis of morphologic and immunohistochemical features. Hysterectomy revealed a polypoid mass measuring 20 mm. After an 18-month follow-up, the patient remains disease free. Here, we review the clinical, pathologic, and immunohistochemical features of uterine tumors resembling ovarian sex cord tumors and endometrial stromal tumors with a sex cord component associated with tamoxifen treatment.
Departments of Pathology (A.G.-P., P.T.-Z., A.P., M.G.-C., J.P.) Gynaecology (D.R.-M., E.M.-B.), Hospital Universitario Ramón y Cajal, Madrid, Spain.
Ana
A
Gutierrez-Pecharroman
Pernilla
P
Tirado-Zambrana
Alejandro
A
Pascual
Dolores
D
Rubio-Marin
Mónica
M
García-Cosío
Enrique
E
Moratalla-Bartolomé
José
J
Palacios
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology*; D013629:Tamoxifen / Q000627:therapeutic use*; D014594:Uterine Neoplasms / Q000473:pathology*
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen