HIF meets NF-κB signaling.
An inflammatory stimulus prior to an ischemic insult can be protective in acute kidney injury (AKI) as well as other acute organ injury models, an effect called cross-tolerance. He et al. investigated mechanisms of cross-tolerance whereby pretreatment with lipopolysaccharide (LPS) protects from a subsequent ischemic insult of the kidney. The protection was mediated by LPS-induced nuclear factor-κB and hypoxia-inducible factor-2α (HIF-2α) signaling. These results link two central cellular pathways and give new insight into HIF-mediated renoprotection in AKI models.
Department of Nephrology and Hypertension, University Erlangen-Nuremberg, Erlangen, Germany.
Carsten
C
Willam
D058186:Acute Kidney Injury / Q000517:prevention & control*; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D015427:Reperfusion Injury / Q000517:prevention & control*; D000099162:Endothelial PAS Domain-Containing Protein 1
D051792:Basic Helix-Loop-Helix Proteins; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D000099162:Endothelial PAS Domain-Containing Protein 1