[The embryonic stem cells research. Example of biotechnology progress under extra-scientific pressure].
The possibility to isolate, cultivate, preserve, characterize and differentiate Human Embryonic Stem Cells (ES) discovered by James Thomson and his colleagues in 1998 was a milestone in the history of Stem Cell Research. Immediately after this discovery many speculations were made about the therapeutic possibilities of ES, motivated by ideological, political and economic aspects. The episode made clear the lack of scientific rationality and ethics when assessing realities as meaningful as those of human embryos obtained by in vitro fertilization techniques (IVF) or human eggs. Therapeutic Cloning as a promise to produce ″tailored″ Stem Cells reported by Hwang and his team in 2004, ended up being a scandal within the scientific community. The technical difficulties and ethical controversies that arose from obtaining ES were insurmountable. In 2010 only two clinical trials were reported using these cells. Those trials were abandoned in late 2011 arguing financial reasons. The discovery of Induced Pluripotent Stem Cell (iPS) in 2006 in mice and in 2007 in humans, represented the possibility of obtaining pluripotent stem cells without the need to destroy embryos. Today, the absence of clinical trials using ES, caused by financial difficulties as a result of its ineffectiveness, anticipates that the use of ES will be limited to certain experimental controls. Probably, the main contribution of Embryonic Stem Cells will be the understanding that biomedical research should follow an ethically and rationally based rigorous method that cannot be ignore.
Universidad Monteávila. 1060a Caracas. jgamez@uma.edu.ve.
José Antonio
JA
Gámez Escalona
D000818:Animals; D002417:Cattle; D002454:Cell Differentiation; D002986:Clinical Trials as Topic / Q000191:economics / Q000941:ethics; D002999:Clone Cells / Q000166:cytology; D019976:Cloning, Organism / Q000941:ethics / Q000331:legislation & jurisprudence; D033041:Embryo Research; D058732:Embryoid Bodies / Q000166:cytology; D053595:Embryonic Stem Cells / Q000166:cytology; D044127:Epigenesis, Genetic; D005307:Fertilization in Vitro; D006801:Humans; D006822:Hybrid Cells; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D008119:Lobbying; D051379:Mice; D053652:Nuclear Transfer Techniques / Q000941:ethics / Q000331:legislation & jurisprudence; D011639:Public Opinion; D015871:Scientific Misconduct; D057905:Stem Cell Research / Q000941:ethics* / Q000331:legislation & jurisprudence; D033581:Stem Cell Transplantation / Q000941:ethics / Q000331:legislation & jurisprudence; D014481:United States