Hiding behind the mycobacterial cell wall.
A recent study has found that pathogenic mycobacteria employ two structurally related cell wall lipids to coordinately recruit macrophages permissive to infection and intracellular replication, all the while inhibiting the recruitment of macrophages with enhanced bactericidal activity. These findings suggest a novel mechanism of immune evasion.
Division of Infectious Diseases, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Howard H
HH
Song
Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address: jun.liu@utoronto.ca.
Jun
J
Liu
D000818:Animals; D005260:Female; D057131:Immune Evasion; D008264:Macrophages / Q000382:microbiology*; D008563:Membrane Lipids / Q000378:metabolism*; D009161:Mycobacterium / Q000502:physiology*
D008563:Membrane Lipids