Calcium level during the first trimester of pregnancy as a predictor of preeclampsia.
OBJECTIVE
To examine the association between calcium levels during the first trimester of pregnancy and preeclampsia.


METHODS
The study population included registered births (n = 5233) in a tertiary medical center between 2001 and 2011. A comparison was performed between women with and without hypocalcemia during the first trimester of pregnancy. A second analysis was performed after correcting calcium levels for albumin. Multiple logistic regression models were used to control for confounders. Receiver operating characteristic curve analysis graphs were used to describe the relationship between the true-positive rate (sensitivity) and the false-positive rate for different values of calcium during the first half of pregnancy in the prediction of preeclampsia.


RESULTS
Of 5233 deliveries, 841 (16%) had hypocalcemia and 4392 (84%) had a normal calcium level. No significant difference were found between the groups regarding mild preeclampsia [odds ratio (OR) = 1.216; 95% confidence interval (CI) 0.831-1.779; p = 0.312], severe preeclampsia (OR = 1.618; 95% CI 0.919-2.849; p = 0.092) and any hypertensive disorders (OR = 1.324; 95% CI 0.963-1.821; p = 0.083).


CONCLUSIONS
Hypocalcemia during the first trimester of pregnancy is not a risk factor for preeclampsia.
Department of Obstetrics & Gynecology .
Aviezer
A
Gabbay
Tamar
T
Tzur
Adi Y
AY
Weintraub
Ilana
I
Shoham-Vardi
Ruslan
R
Sergienko
Eyal
E
Sheiner
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002118:Calcium / Q000097:blood*; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000175:diagnosis*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D012307:Risk Factors; D055815:Young Adult
D015415:Biomarkers; D002118:Calcium
Calcium; Hypertensive disorders.; Hypocalcemia; Preeclampsia