The effects of two Lactobacillus plantarum strains on rat lipid metabolism receiving a high fat diet.
The aim of our study was to evaluate the effects of the different probiotic strains, Lactobacillus plantarum LS/07 and Lactobacillus plantarum Biocenol LP96, on lipid metabolism and body weight in rats fed a high fat diet. Compared with the high fat diet group, the results showed that Lactobacillus plantarum LS/07 reduced serum cholesterol and LDL cholesterol, but Lactobacillus plantarum Biocenol LP96 decreased triglycerides and VLDL, while there was no change in the serum HDL level and liver lipids. Both probiotic strains lowered total bile acids in serum. Our strains have no significant change in body weight, gain weight, and body fat. These findings indicate that the effect of lactobacilli on lipid metabolism may differ among strains and that the Lactobacillus plantarum LS/07 and Lactobacillus plantarum Biocenol LP96 can be used to improve lipid profile and can contribute to a healthier bowel microbial balance.
Institute of Experimental Medicine, Faculty of Medicine, P. J. Šafárik University, Trieda SNP 1, 040 01 Košice, Slovakia.
Rastislav
R
Salaj
Institute of Experimental Medicine, Faculty of Medicine, P. J. Šafárik University, Trieda SNP 1, 040 01 Košice, Slovakia.
Jana
J
Stofilová
Institute of Experimental Medicine, Faculty of Medicine, P. J. Šafárik University, Trieda SNP 1, 040 01 Košice, Slovakia.
Alena
A
Soltesová
Department of Medical and Clinical Biochemistry, Faculty of Medicine, P. J. Šafárik University, Trieda SNP 1, 040 01 Košice, Slovakia.
Zdenka
Z
Hertelyová
Institute of Experimental Medicine, Faculty of Medicine, P. J. Šafárik University, Trieda SNP 1, 040 01 Košice, Slovakia.
Emília
E
Hijová
Institute of Experimental Medicine, Faculty of Medicine, P. J. Šafárik University, Trieda SNP 1, 040 01 Košice, Slovakia.
Izabela
I
Bertková
Institute of Experimental Medicine, Faculty of Medicine, P. J. Šafárik University, Trieda SNP 1, 040 01 Košice, Slovakia.
Ladislav
L
Strojný
Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne's Faculty Hospital, Masaryk University, Pekařská 53, 656 91 Brno, Czech Republic.
Peter
P
Kružliak
Institute of Experimental Medicine, Faculty of Medicine, P. J. Šafárik University, Trieda SNP 1, 040 01 Košice, Slovakia.
Alojz
A
Bomba
D000818:Animals; D001835:Body Weight; D059305:Diet, High-Fat; D005966:Glucuronidase / Q000378:metabolism; D048191:Lactiplantibacillus plantarum / Q000201:enzymology / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D019936:Probiotics / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats
D008055:Lipids; D005966:Glucuronidase