Escape of DNA from a weakly biased thin nanopore: experimental evidence for a universal diffusive behavior.
We report experimental escape time distributions of double-stranded DNA molecules initially threaded halfway through a thin solid-state nanopore. We find a universal behavior of the escape time distributions consistent with a one-dimensional first passage formulation notwithstanding the geometry of the experiment and the potential role of complex molecule-liquid-pore interactions. Diffusion constants that depend on the molecule length and pore size are determined. Also discussed are the practical implications of long time diffusive molecule trapping in the nanopore.
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.
David P
DP
Hoogerheide
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA.
Fernando
F
Albertorio
Department of Physics, Harvard University, Cambridge, Massachusetts 02138, USA and School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA.
Jene A
JA
Golovchenko
D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004058:Diffusion; D008956:Models, Chemical; D058608:Nanopores
D004247:DNA