Limited geographic distribution of the novel cyclovirus CyCV-VN.
A novel cyclovirus, CyCV-VN, was recently identified in cerebrospinal fluid (CSF) from patients with central nervous system (CNS) infections in central and southern Vietnam. To explore the geographic distribution of this novel virus, more than 600 CSF specimens from patients with suspected CNS infections in northern Vietnam, Cambodia, Nepal and The Netherlands were screened for the presence of CyCV-VN but all were negative. Sequence comparison and phylogenetic analysis between CyCV-VN and another novel cyclovirus recently identified in CSF from Malawian patients indicated that these represent distinct cycloviral species, albeit phylogenetically closely related. The data suggest that CyCV-VN has a limited geographic distribution within southern and central Vietnam. Further research is needed to determine the global distribution and diversity of cycloviruses and importantly their possible association with human disease.
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Van Tan
VT
Le
1] Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam [2] Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Menno D
MD
de Jong
1] National Hospital for Tropical Diseases, Hanoi, Vietnam [2] Hanoi Medical University, Hanoi, Vietnam.
Van Kinh
VK
Nguyen
1] National Hospital for Tropical Diseases, Hanoi, Vietnam [2] Hanoi Medical University, Hanoi, Vietnam.
Vu Trung
VT
Nguyen
1] Oxford University Clinical Research Unit, Hanoi, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Walter
W
Taylor
1] Oxford University Clinical Research Unit, Hanoi, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Heiman F L
HF
Wertheim
1] Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands [2] The Netherlands National Reference Laboratory for Bacterial Meningitis, Amsterdam, the Netherlands.
Arie
A
van der Ende
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Lia
L
van der Hoek
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Marta
M
Canuti
Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Martin
M
Crusat
Angkor Hospital for Children, Siem Reap, Kingdom of Cambodia.
Soeng
S
Sona
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Hanh Uyen
HU
Nguyen
Oxford University Clinical Research Unit, Patan Hospital, Kathmandu, Nepal.
Abhishek
A
Giri
Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.
Thi Thuy Chinh Bkrong
TT
Nguyen
1] Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam [2] Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam [3] Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
Dang Trung Nghia
DT
Ho
1] Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Jeremy
J
Farrar
1] Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Juliet E
JE
Bryant
1] Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Tinh Hien
TH
Tran
Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
Van Vinh Chau
VV
Nguyen
1] Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam [2] Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
H Rogier
HR
van Doorn
D000328:Adult; D001483:Base Sequence; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000821:virology*; D002648:Child; D018136:Circoviridae / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D018173:Circoviridae Infections / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D016679:Genome, Viral; D005843:Geography; D006801:Humans; D008295:Malawi / Q000453:epidemiology; D008297:Male; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D014744:Vietnam / Q000453:epidemiology
D004279:DNA, Viral