Effects of electromagnetic pulse on serum element levels in rat.
Electromagnetic pulse (EMP) was a potentially harmful factor to the human body, and a biological dosimetry to evaluate effects of EMP is necessary. Little is known about effects of EMP on concentration of macro and trace elements in serum so far. In this study, Sprague-Dawley rats were randomly divided into 50-kV/m EMP-exposed group (n = 10), 100-kV/m EMP-exposed group (n = 10), 200-kV/m EMP-exposed group (n = 40), and the sham-exposed group (n = 20). The macro and trace element concentrations in serum were examined at 6, 12, 24, and 48 h after EMP exposure at different electric field intensities. Compared with the sham-exposed groups, the concentration of sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), zinc (Zn), copper (Cu), iron (Fe), selenium (Se), and manganese (Mn) in rat serum was not changed significantly within 48 h after 200 pulses of EMP exposure at electric field intensity of 50, 100, and 200 kV/m although the K level was decreased and the Ca level was increased with the electric field intensity of EMP increasing. In addition, there was a tendency that the Zn level was decreased with the time going on within 48 h after EMP exposure. Under our experimental conditions, EMP exposure cannot affect the concentration of macro and trace elements in rat serum. There was no time-effect or dose-effect relationship between EMP exposure and serum element levels. The macro and trace elements in serum are not suitable endpoints of biological dosimetry of EMP.
Department of Radiation Medicine and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Fourth Military Medical University, Xi'an, 710032, Shaanxi, People's Republic of China.
Kangchu
K
Li
Shirong
S
Ma
Dongqing
D
Ren
Yurong
Y
Li
Guirong
G
Ding
Junye
J
Liu
Yao
Y
Guo
Guozhen
G
Guo
D000818:Animals; D002118:Calcium / Q000097:blood; D003300:Copper / Q000097:blood; D004574:Electromagnetic Fields; D006801:Humans; D007501:Iron / Q000097:blood; D008274:Magnesium / Q000097:blood; D008297:Male; D008345:Manganese / Q000097:blood; D011188:Potassium / Q000097:blood; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000097:blood; D012964:Sodium / Q000097:blood; D013054:Spectrophotometry, Atomic / Q000379:methods; D013997:Time Factors; D014131:Trace Elements / Q000097:blood*; D015032:Zinc / Q000097:blood
D014131:Trace Elements; D008345:Manganese; D003300:Copper; D012964:Sodium; D007501:Iron; D012643:Selenium; D008274:Magnesium; D015032:Zinc; D011188:Potassium; D002118:Calcium