EGFR mutation of adenocarcinoma in congenital cystic adenomatoid malformation/congenital pulmonary airway malformation: a case report.
An 80-year-old man underwent right upper lobectomy for the resection of multiple cysts accompanied by a nodule. The pathological diagnosis was adenocarcinoma with surrounding atypical epithelial cell proliferation in a Type 1 congenital cystic adenomatoid malformation/congenital pulmonary airway malformation. There was epidermal growth factor receptor mutation in the adenocarcinoma and surrounding atypical epithelial cells that had proliferated. Malignant transformation of congenital cystic adenomatoid malformation/congenital pulmonary airway malformation may be related to the epidermal growth factor receptor pathway in this case, with atypical epithelial cell proliferation as a precursor. We emphasize the importance of complete resection of congenital cystic adenomatoid malformation/congenital pulmonary airway malformation and the possibility of treatment with epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor-mutated cases.
*Department of Respiratory Medicine, Tokyo Women's Medical University, Yachiyo Medical Center, 477-96 Owada-Shinden, Yachiyo, Chiba 276-8524, Japan. hasemizue@yahoo.co.jp.
Mizue
M
Hasegawa
Fumikazu
F
Sakai
Ken
K
Arimura
Hideki
H
Katsura
Eitetsu
E
Koh
Yasuo
Y
Sekine
Kenzo
K
Hiroshima
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery*; D000077192:Adenocarcinoma of Lung; D000369:Aged, 80 and over; D002471:Cell Transformation, Neoplastic; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000473:pathology*; D066246:ErbB Receptors / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000601:surgery*; D008297:Male; D009154:Mutation; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*
D047428:Protein Kinase Inhibitors; D066246:ErbB Receptors; D011505:Protein-Tyrosine Kinases
EGFR genes; congenital cystic adenomatoid malformation; lung cancer