Hollow superparamagnetic PLGA/Fe3O4 composite microspheres for lysozyme adsorption.
Uniform hollow superparamagnetic poly(lactic-co-glycolic acid) (PLGA)/Fe(3)O(4) composite microspheres composed of an inner cavity, PLGA inner shell and Fe(3)O(4) outer shell have been synthesized by a modified oil-in-water (O/W) emulsion-solvent evaporation method using Fe(3)O(4) nanoparticles as a particulate emulsifier. The obtained composite microspheres with an average diameter of 2.5 μm showed excellent monodispersity and stability in aqueous medium, strong magnetic responsiveness, high magnetite content (>68%), high saturation magnetization (58 emu g(-1)) and high efficiency in lysozyme adsorption.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, People's Republic of China.
Qi
Q
Yang
Yao
Y
Wu
Fang
F
Lan
Shaohua
S
Ma
Liqin
L
Xie
Bin
B
He
Zhongwei
Z
Gu
D000327:Adsorption; D052203:Ferrosoferric Oxide; D019344:Lactic Acid; D008863:Microspheres; D009113:Muramidase / Q000737:chemistry*; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D009113:Muramidase; D052203:Ferrosoferric Oxide