Concise synthesis of reduced propionates by stereoselective reductions combined with the Kobayashi reaction.
A concise and straightforward synthesis of 2,4,6-trimethyloctanoates was established by using the sequence of the vinylogous Mukaiyama aldol reaction and regio- and stereoselective reduction reactions. All isomers were obtained selectively in a few steps. The short step synthesis of septoriamycin A, an antimalarial and antileishmanial agent, has been achieved by this methodology.
Department of Applied Chemistry, Faculty of Advanced Science and Engineering, Waseda University , 3-4-1 Ohkubo, Shinjuku-ku, Tokyo 169-8555, Japan.
Tatsuya
T
Nakamura
Mio
M
Harachi
Takaaki
T
Kano
Yuki
Y
Mukaeda
Seijiro
S
Hosokawa
D002210:Caprylates / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D002210:Caprylates; D011422:Propionates