Role of propolis on biochemical parameters in kidney and heart tissues against L-NAME induced oxidative injury in rats.
Nitric oxide (NO), produced by endothelial NO synthase, is recognised as a central antiinflammatory and antiatherogenic principle in the vasculature. Epidemiological and clinical studies have demonstrated that a growing list of natural products, as components of the daily diet or phytomedical preparations, may improve vascular function by enhancing NO bioavailability. In this article, we investigated antioxidant effects of propolis on biochemical parameters in kidney and heart tissues of acute NO synthase inhibited rats by Nω-nitro-l-arginine methyl ester (l-NAME). There was increase (p < 0.001) in the activities of catalase and malondialdehyde levels in the l-NAME treatment groups when compared with control rats, but NO levels were decreased in both kidney and heart tissues. There were statistically significant changes (p < 0.001) in these parameters of l-NAME + propolis treated rats as compared with l-NAME-treated group. In summary, propolis may influence endothelial NO production.
Department of Biology, Faculty of Arts and Sciences, Nigde University , Nigde , Turkey .
Zeliha Selamoglu
ZS
Talas
Ilknur
I
Ozdemir
Osman
O
Ciftci
Oguz
O
Cakir
Mehmet Fuat
MF
Gulhan
Oguz Murat
OM
Pasaoglu
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000633:toxicity; D006321:Heart / Q000187:drug effects*; D006335:Heart Injuries / Q000188:drug therapy / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000293:injuries* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000633:toxicity; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D011429:Propolis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D008315:Malondialdehyde; D011429:Propolis; D002374:Catalase; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester
Catalase; l-NAME; malondialdehyde; nitric oxide; propolis; rat