Comparative effectiveness of two metronomic chemotherapy schedules-our experience in the preclinical field.
Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis growth, survival, and toxicity. Metronomic chemotherapy with Cyclophosphamide + Celecoxib (Cy + Cel) showed higher antimetastatic power than Cyclophosphamide + Doxorubicin (Cy + Dox), while being similar in other aspects. That difference, plus the advantage that represents its oral administration, suggests that the Cy + Cel combination is more suitable than Cy + Dox for metronomic chemotherapy of mammary tumors and could be proposed to the translation to the clinic.
Institute of Experimental Genetics, School of Medical Sciences, National University of Rosario , Rosario , Argentina.
M J
MJ
Rico
H A
HA
Perroud
L E
LE
Mainetti
V R
VR
Rozados
O G
OG
Scharovsky
D000704:Analysis of Variance; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D005260:Female; D008175:Lung Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D051379:Mice; D009362:Neoplasm Metastasis; D047368:Tumor Burden / Q000187:drug effects