Influencing Factors and Predictors of Early Response in Schizophrenia Patients Receiving the Paliperidone Extended-Release Tablets (Paliperidone ER).
OBJECTIVE
Paliperidone extended-release tablet (paliperidone ER) is a new oral psychotropic agent developed for schizophrenia treatment. There have been some studies about paliperidone's good efficacy and tolerability. Clinicians appear to change the antipsychotic medication to paliperidone ER. However, it is not known what patients are favorable responsive to paliperidone ER. The aim of this study was to evaluate the characteristics of early responders and investigate predictors of acute response when the medications changed to paliperidone ER.


METHODS
Data were analyzed from schizophrenic patients who participated in a multi-center, open-label, non-comparative clinical trial. Total 320 patients were examined in this study. Sociodemographic, psychopathology, social function and metabolic data were evaluated. Unpaired t-test for continuous and χ(2) for categorical data, respectively, were used to compare early responder and non-responders. Logistic regression analysis was used to establish a prediction model.


RESULTS
38.7% of study subjects (124 of 320) responded to paliperidone ER treatment. Logistic regression analysis showed that a good paliperidone ER response was more likely when patients were social drinkers, when patients had started medication at inpatient, when negative symptoms were less severe, and when patients' social relationship and self-care were better.


CONCLUSIONS
Early response to paliperidone ER treatment is associated with less negative symptoms and good social relationships and self-care. Strategies to reduce these symptoms may contribute to early response to paliperidone ER.
Department of Psychiatry, Inha University Hospital, Incheon, Republic of Korea.
Seung-Ho
SH
Jung
Department of Psychiatry, Chonnam National University, Gwangju, Republic of Korea.
Jin-Sang
JS
Yoon
Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Yong-Min
YM
Ahn
Department of Psychiatry, Dongguk University Ilsan Hospital, Goyang, Republic of Korea.
Yong-Sik
YS
Kim
Department of Psychiatry, Inha University Hospital, Incheon, Republic of Korea.
Chul-Eung
CE
Kim
Antipsychotics; Early response; Paliperidone ER; Predictors; Schizophrenia