Health-related quality of life in small-cell lung cancer: a systematic review on reporting of methods and clinical issues in randomised controlled trials.
Small-cell lung cancer represents about 15% of all lung cancers; increasingly, randomised controlled trials of this disease measure the health-related quality of life of patients. In this Systematic Review we assess the adequacy of reporting of health-related quality-of-life methods in randomised controlled trials of small-cell lung cancer, and the potential effect of this reporting on clinical decision making. Although overall reporting of health-related quality of life was acceptable, improvements are needed to optimise the use of health-related quality of life in randomised controlled trials.
Quality of Life Department, EORTC Headquarters, Brussels, Belgium. Electronic address: efstathios.zikos@eortc.be.
Efstathios
E
Zikos
Quality of Life Department, EORTC Headquarters, Brussels, Belgium.
Irina
I
Ghislain
Quality of Life Department, EORTC Headquarters, Brussels, Belgium.
Corneel
C
Coens
Quality of Life Department, EORTC Headquarters, Brussels, Belgium.
Divine E
DE
Ediebah
New England Center for Children, Southborough, Massachusetts, MA, USA.
Elizabeth
E
Sloan
European Centre for Disease Prevention and Control, Surveillance and Response Support Unit, Stockholm, Sweden.
Chantal
C
Quinten
University Hospital Regensburg, Center for Clinical Studies, Regensburg, Germany.
Michael
M
Koller
Multidisciplinary Oncology Centre Antwerp (MOCA)/Thoracic Oncology, Antwerp University Hospital, Edegem, Belgium.
Jan P
JP
van Meerbeeck
University of Magdeburg, Child and Adolescent Psychiatry and Psychotherapy, Magdeburg, Germany.
Hans-Henning
HH
Flechtner
Department of Oncology and Cancer Center, University Hospital Zurich, Zurich, Switzerland.
Roger
R
Stupp
Clinical Research Physicians Unit, EORTC Headquarters, Brussels, Belgium.
Athanasios
A
Pallis
Hungaroprax NC, Budapest, Hungary.
Agnes
A
Czimbalmos
Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Mirjam A G
MA
Sprangers
Quality of Life Department, EORTC Headquarters, Brussels, Belgium.
Andrew
A
Bottomley
D000203:Activities of Daily Living; D000223:Adaptation, Psychological; D017281:Cost of Illness; D019317:Evidence-Based Medicine; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy; D011379:Prognosis; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic / Q000379:methods*; D012107:Research Design; D055752:Small Cell Lung Carcinoma / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy; D011795:Surveys and Questionnaires