Retromer: a master conductor of endosome sorting.
The endosomal network comprises an interconnected network of membranous compartments whose primary function is to receive, dissociate, and sort cargo that originates from the plasma membrane and the biosynthetic pathway. A major challenge in cell biology is to achieve a thorough molecular description of how this network operates, and in so doing, how defects contribute to the etiology and pathology of human disease. We discuss the increasing body of evidence that implicates an ancient evolutionary conserved complex, termed "retromer," as a master conductor in the complex orchestration of multiple cargo-sorting events within the endosomal network.
Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut 06520.
Christopher
C
Burd
Peter J
PJ
Cullen
D011992:Endosomes / Q000502:physiology*; D006801:Humans; D021381:Protein Transport / Q000502:physiology*; D033921:Vesicular Transport Proteins / Q000502:physiology*; D021601:trans-Golgi Network / Q000502:physiology*
D033921:Vesicular Transport Proteins