Rational design of sulfoxide-phosphine ligands for Pd-catalyzed enantioselective allylic alkylation reactions.
A new type of chiral sulfoxide-phosphine ligands have been developed by a rational combination of two privileged scaffolds for Pd-catalyzed asymmetric allylic alkylation reactions. Under optimized conditions, generally high yields (up to 97%) and excellent enantioselectivities (up to >99% ee) were obtained.
Key Laboratory of Pesticide & Chemical Biology of Education, Ministry College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China. chenjiarong@mail.ccnu.edu.cn wxiao@mail.ccnu.edu.cn.
Hong-Gang
HG
Cheng
Bin
B
Feng
Li-Yan
LY
Chen
Wei
W
Guo
Xiao-Ye
XY
Yu
Liang-Qiu
LQ
Lu
Jia-Rong
JR
Chen
Wen-Jing
WJ
Xiao
D000478:Alkylation; D002384:Catalysis; D008024:Ligands; D010165:Palladium / Q000737:chemistry*; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013454:Sulfoxides / Q000138:chemical synthesis* / Q000737:chemistry
D008024:Ligands; D010720:Phosphines; D013454:Sulfoxides; D010165:Palladium