Methods for delivery of genes to hepatocytes in vivo using recombinant adenovirus vectors.
In many ways, the liver represents an ideal target organ for gene delivery. Anatomically, the sheer bulk cof its tissue mass and its dual blood supply are advantageous for intravascular injection of virus into either portal or systemic circulation. The portal vein provides a direct iv route into the liver. It also theoretically provides an indirect route by oral administration since the portal system drains the gut.
Division of Transplantation, Department of Surgery, University of Washington, Seattle, WA.
D
D
Barr
M A
MA
Kay