Clinical utility of serum cystatin C in predicting coronary artery disease in patients without chronic kidney disease.
BACKGROUND
Cystatin C has been proposed as a novel marker of renal function and predictor of cardiovascular risk. The aim of this study was to investigate the role of cystatin C level as a predictor of cardiovascular events in patients with coronary artery disease (CAD).


METHODS
Three hundred and five coronary artery patients were included in this study. Serum cystatin C levels, high-sensitive C-reactive protein (hs-CRP), and oxidative stress were measured. Estimated glomerular filtration rate (eGFR) and the CAD severity score were calculated.


RESULTS
Cystatin C was correlated with the CAD severity score (r = 0.631, P < 0.0001) and was significantly elevated in the CAD severity score >50. Every 0.1 mg/l increase in cystatin C, 2 mg/l increase in hs-CRP, 0.2 mmol/l decrease in high-density lipoprotein cholesterol, 13.7 ml/min decrease in eGFR, and 1.51 μmol/l increase in homocysteine caused a 34, 12, 5, and 22% increase in the risk of having CAD, respectively.


CONCLUSIONS
Cystatin C could be a useful laboratory biochemical marker in predicting the severity of CAD. Cystatin C is associated with biochemical atherosclerosis markers such as CRP and homocysteine.
Department of Clinical Biochemistry, CHU-Farhat Hached, Sousse, Tunisia.
Azza
A
Dandana
Imen
I
Gammoudi
Abdelkader
A
Chalghoum
Hinda
H
Chahed
Faouzi
F
Addad
Salima
S
Ferchichi
Abdelhedi
A
Miled
D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008075:Lipoproteins, HDL; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D051436:Renal Insufficiency, Chronic / Q000097:blood; D012307:Risk Factors
D015415:Biomarkers; D055316:Cystatin C; D008075:Lipoproteins, HDL; D002097:C-Reactive Protein
Estimated glomerular filtration rate; biochemical atherosclerosis markers; coronary artery disease; cystatin C