Thermally switchable polymers achieve controlled Escherichia coli detachment.
The thermally triggered release of up to 96% of attached uropathogenic E. coli is achieved on two polymers with opposite changes in surface wettability upon reduction in temperature. This demonstrates that the bacterial attachment to a surface cannot be explained in terms of water contact angle alone; rather, the surface composition of the polymer plays the key role.
Laboratory of Biophysics and Surface Analysis, School of Pharmacy, University of Nottingham, Nottingham, NG72RD, UK.
Andrew L
AL
Hook
Chien-Yi
CY
Chang
David J
DJ
Scurr
Robert
R
Langer
Daniel G
DG
Anderson
Paul
P
Williams
Martyn C
MC
Davies
Morgan R
MR
Alexander
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects; D004926:Escherichia coli / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties; D013696:Temperature; D017155:Wettability
D000900:Anti-Bacterial Agents; D011108:Polymers
Escherichia coli; ToF-SIMS; switchable polymers; thermal responsiveness