Comparison of the antifungal efficacy of terbinafine hydrochloride and ciclopirox olamine containing formulations against the dermatophyte Trichophyton rubrum in an infected nail plate model.
Onychomycosis is a fungal infection mostly induced by dermatophytes such as Trichophyton rubrum. Due to slow nail growth, the treatment takes 3-9 months depending on the nail size and infected area. Hence, high efficacy of the active ingredient without systemic side effects is of major interest. To test the efficacy of an antifungal formulation, an appropriate in vitro model reflecting the in vivo situation as close as possible is required. In this study, a variety of antifungal formulations, i.e., commercial ones (Ciclopoli and Lamisil cream), those used in compounding pharmacies (Pentravan) as well as poloxamer 407-based systems, have been evaluated in an infected nail plate model. The active pharmaceutical ingredients (APIs) were ciclopirox olamine and terbinafine hydrochloride. The poloxamer 407-based formulations consisted of poloxamer 407, double distilled water, propylene glycol, isopropyl alcohol, medium chain triglycerides and either 1% ciclopirox olamine or 1% terbinafine hydrochloride as API, respectively. Former studies have shown high permeation rates of terbinafine hydrochloride from similar poloxamer 407-based formulations with dimethyl isosorbide instead of propylene glycol. The present contribution shows superior inhibition of T. rubrum growth from poloxamer 407-based formulations in comparison to the commercial Lamisil cream. Moreover, poloxamer 407-based formulations were equally effective as the nail lacquer Ciclopoli even though the poloxamer formulations contained only 1% of the drug instead of 8% in the marketed lacquer. Poloxamer 407-based systems containing ciclopirox olamine proved to be about as effective as similar terbinafine hydrochloride systems.
Institut für Pharmazeutische Technologie, Technische Universität Braunschweig , Mendelssohnstraße 1, 38106 Braunschweig, Germany.
Anja
A
Täuber
Christel C
CC
Müller-Goymann
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D002417:Cattle; D002626:Chemistry, Pharmaceutical / Q000379:methods; D000077768:Ciclopirox; D005533:Foot Dermatoses / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D005534:Foot Diseases / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D006724:Hoof and Claw / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D014009:Onychomycosis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary; D020442:Poloxamer / Q000737:chemistry; D011728:Pyridones / Q000737:chemistry / Q000494:pharmacology*; D000077291:Terbinafine; D014249:Trichophyton / Q000187:drug effects*
D000935:Antifungal Agents; D009281:Naphthalenes; D011728:Pyridones; D020442:Poloxamer; D000077768:Ciclopirox; D000077291:Terbinafine