[Effects of nano-selenium on antioxidant capacity and histopathology of Cyprinus carpio liver under fluoride stress].
To evaluate the protection effect of nano-selenium (NSe) on the antioxidant capacity and histopathology of Cyprinus carpio liver under fluoride stress, a total of 750 C. carpio individuals were randomly divided into five groups, i. e., no fluoride stress and NSe addition (CK), fluoride (100 mg F- x L(-1))-stressed (FS), and fluoride-stressed plus NSe added with a dosage of 0.1 mg Se x L(-1) (NSe L), 0.5 mg Se x L(-1) (NSe M), and 1.0 mg Se x kg(-1)(NSe H). The NSe was mixed with fish foods, and the fishes of FS and NSe groups were exposed to the fluoride stress for 30 days. As compared with CK, fluoride stress decreased the SOD, CAT, and GSH-Px activities and increased the MDA content of C. carpio liver, and induced a definite damage on the histopathology of the liver. Compared with FS, NSe increased the liver SOD, CAT, and GSH-Px activities, decreased the liver MDA content, and mitigated the damage of fluoride stress on the histopathology of the liver. The results demonstrated that in some extent, the addition of NSe into fish foods could alleviate the decline of the antioxidant capacity of C. carpio liver and the damage on the liver histopathology caused by fluoride stress.
Shanxi Province Key Laboratory of Ecological Animal Husbandry and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, China. 710425649@qq.com
Jian-Jie
JJ
Chen
Shanxi Province Key Laboratory of Ecological Animal Husbandry and Environmental Veterinary Medicine, College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, China.
Jin-Ling
JL
Cao
Guangxi Institute of Fisheries, Nanning 530021, China.
Yong-Ju
YJ
Luo
Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, Jiangsu, China.
Ju-Yin
JY
Li
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002347:Carps / Q000502:physiology*; D002374:Catalase / Q000378:metabolism; D002681:China; D005459:Fluorides / Q000633:toxicity*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D053768:Metal Nanoparticles; D012643:Selenium / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D012643:Selenium; D005459:Fluorides