Outcome of Intravenous Immunoglobulin-Transmitted HTLV-I, Hepatitis B, Hepatitis C, and HIV infections.
OBJECTIVE
Since each unit of Intravenous Immunoglobulin (IVIG) is obtained from different blood donors, blood-borne viral diseases is of high importance. We aimed at investigating the prevalence of various viral infections: Human T-cell Lymphotropic Virus Type 1 (HTLV-I), Hepatitis B (HBV), Hepatitis C (HCV), and Human Immunodeficiency Virus (HIV) among patients referred for IVIG therapy section in Mashhad University of Medical Sciences, Mashhad, Iran.


METHODS
A prospective study was conducted on 130 IVIG recipients admitted to different wards of our Medical Centre: Immunology, Hematology, and Neurology, in 2010. After filling the informed consent form, a 5 cc blood sample was initially taken from each patient. Viral infections including HTLV-I Ab, HIV-Ab, HBsAg, HBc-Ab, and HBV-Ab were assessed using the ELISA technique before and after six three months treatment.


RESULTS
Test results for HTLV-I Ab, HBsAg, HBc Ab, HIV Ab, and HCV Ab were negative in all cases before IVIG therapy. After receiving IVIG, two female cases with CIDP showed positive results for HBV Ab (0.8%) and HBS Ag (0.8%) with ELISA and only one patient confirmed with PCR. There was not any significant relation between HBV Ag (P=0.14) and HBC Ab with type of disorder (P=0.66).


CONCLUSIONS
This study showed that HTLV-I viral replication and the other investigated viral transmissions do not occur in plasma; therefore, the IVIG products are safe.
Neurology Department, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohsen
M
Foroughipour
Allergy Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Farahzad
F
Jabbari Azad
Immunology Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza
R
Farid Hosseini
Internal Medicine Department, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Abbas
A
Shirdel
Internal Medicine Department, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Amir Reza
AR
Khalighi
Student Research Assembly of Mashhad University of Medical Sciences, Mashhad, Iran.
Hadis
H
Yousefzadeh
Allergy Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Homa
H
Sadri
Preventive Cardiovascular Care Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
Toktam
T
Moghiman
Preventive Cardiovascular Care Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran.
Hossein
H
Hekmatkhah
Hepatitis B virus; Hepatitis C virus; Immune Deficiency; Intravenous Immunoglobulin