[Regulation and disorders of calcium and phosphate metabolism].
Calcium and phosphate are the constituents of biomineral, and their levels in circulation are regulated by various hormones. Disorders in calcium/phosphate metabolism are often associated with skeletal demineralization and pathological calcification. Some of the hypophosphatemic rickets/osteomalacia are caused by the increased bioactivity of FGF23, and classified into FGF23-mediated hypophosphatemic rickets/osteomalacia. In the adult patients with FGF23-mediated hypophosphatemic rickets/osteomalacia, mineralizing enthesopathy is an often observed complication. In addition, mutations of the same genes can be responsible for both rickets/osteomalacia and ectopic calcification.
Department of Bone and Mineral Research, Osaka Medical Center and Research Institute for Maternal and Child Health, Japan.
Toshimi
T
Michigami
D000818:Animals; D002113:Calcification, Physiologic / Q000502:physiology; D002118:Calcium / Q000378:metabolism*; D053098:Familial Hypophosphatemic Rickets / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism; D006801:Humans; D010018:Osteomalacia / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism*
C000717427:FGF23 protein, human; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D002118:Calcium