Cohort study of diabetes in HIV-infected adult patients: evaluating the effect of diabetes mellitus on immune reconstitution.
We conducted a retrospective cohort study assessing the association between diabetes mellitus (DM) and immune recovery in HIV-infected adults. Immune reconstitution after initiating antiretroviral therapy was more rapid in DM patients (120.4 cells/year) compared to non-DM patients (94.2 cells/year, p<0.023). Metformin use was associated with improved CD4 recovery (p=0.034).
Institute for Health Sciences, Gaborone, Botswana.
D
D
Moyo
Institute for Health Sciences, Gaborone, Botswana.
G
G
Tanthuma
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, United States.
M S
MS
Cary
Institute for Health Sciences, Gaborone, Botswana.
O
O
Mushisha
Institute for Health Sciences, Gaborone, Botswana.
G
G
Kwadiba
Institute for Health Sciences, Gaborone, Botswana.
F
F
Chikuse
Botswana-UPenn Partnership, Gaborone, Botswana; Perelman School of Medicine, University of Pennsylvania, United States; Center for AIDS Research, University of Pennsylvania, United States; Department of Pediatrics, Division of Infectious Diseases, The Children's Hospital of Philadelphia, United States; University of Botswana, School of Medicine, Botswana.
A P
AP
Steenhoff
Botswana-UPenn Partnership, Gaborone, Botswana; Perelman School of Medicine, University of Pennsylvania, United States. Electronic address: michael.j.a.reid@gmail.com.
M J A
MJ
Reid
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
D007004:Hypoglycemic Agents; D008687:Metformin
CD4 count; HIV; Immune reconstitution; Metformin