Sleep and protein synthesis-dependent synaptic plasticity: impacts of sleep loss and stress.
Sleep has been ascribed a critical role in cognitive functioning. Several lines of evidence implicate sleep in the consolidation of synaptic plasticity and long-term memory. Stress disrupts sleep while impairing synaptic plasticity and cognitive performance. Here, we discuss evidence linking sleep to mechanisms of protein synthesis-dependent synaptic plasticity and synaptic scaling. We then consider how disruption of sleep by acute and chronic stress may impair these mechanisms and degrade sleep function.
Department of Biological and Medical Psychology, University of Bergen Bergen, Norway ; Norwegian Competence Center for Sleep Disorders, Haukeland University Hospital Bergen, Norway.
Janne
J
Grønli
Department of Biological and Medical Psychology, University of Bergen Bergen, Norway.
Jonathan
J
Soulé
Department of Biomedicine and KG Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen Bergen, Norway.
Clive R
CR
Bramham
Arc/Arg3.1; brain-derived neurotrophic factor; gene expression; long-term potentiation; mood disorder; sleep deprivation; stress; translation control