Role of clinical and paraclinical manifestations of methanol poisoning in outcome prediction.
BACKGROUND
Methanol poisoning is one of the most important poisoning due to drinking of illegal and non-standard alcoholic beverage in some countries. Relatively limited studies have been carried out to identify the prognostic factors in methanol poisoning.


METHODS
We performed a retrospective study on acute methanol-intoxicated patients, which were admitted on the Loghman Hakim Hospital Poison Center (Tehran, Iran) over a 24-month period. The demographic data, clinical manifestations and paraclinical findings, therapeutic interventions and outcome (survivors with or without complications and non-survivors) were extracted.


RESULTS
We evaluated 30 patients with methanol poisoning during 2 years. All of the patients were male; with the median age of 25.5 years. Visual disturbances, respiratory manifestations, and loss of consciousness were the most common clinical manifestations on admission time. The results of paraclinical manifestations on admission time were as following: The median of blood methanol level was 20 mg/dL. The median of pH, PaCO2 and HCO3 was 7.15, 22.35 mmHg and 7.2 mEq/L, respectively. Hyperglycemia was observed in 70% of the patients and the median of blood glucose was 184.5 mg/dL. In fourteen of the patients hemodialysis was performed. Median duration of hospitalization was 48 h. Nine of the patients died. There was a significant difference between survivors and non-survivors with regard to coma, blood methanol level, and PaCO2 and blood glucose. Furthermore, we did not observe a significant difference between these two groups regarding to pH, HCO3 level, and time interval between alcohol ingestion to hospital admission and beginning of hemodialysis.


CONCLUSIONS
Regarding the results of this study, it can be suggested that coma, PaCO2 and hyperglycemia on admission time could be used as strong predictors of poor outcome.
Excellent Center of Clinical Toxicology, Toxicological Research Center, Clinical Toxicology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shahin
S
Shadnia
Excellent Center of Clinical Toxicology, Toxicological Research Center, Clinical Toxicology Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mojgan
M
Rahimi
Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran.
Kambiz
K
Soltaninejad
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Amir
A
Nilli
Hyperglycemia; methanol; outcome; partial pressure of carbon dioxide; poisoning; prognostic factors