Histological protection by nilvadipine against neurotoxicity induced by NOC12, a nitric oxide donor, in the rat retina.
In the present study, we histologically examined the effects of nilvadipine on neuronal injury induced by intravitreal (i.v.) N-methyl-D-aspartate (NMDA) (200 nmol/eye) and intravitreal NOC12 (400 nmol/eye), a nitric oxide donor, in the rat retina. Morphometric evaluation at 7 d after injection of NMDA or NOC12 showed that treatment with nilvadipine (1 mg/kg, i.v.) 15 min prior to injection of NMDA or NOC12 dramatically reduced the retinal damage. These results suggest that nilvadipine protects neurons against excitotoxic injury in the rat retina in vivo at least in part via an antioxidative effect.
Department of Molecular Pharmacology, Kitasato University School of Pharmaceutical Sciences.
Taiyo
T
Kuroki
Asami
A
Mori
Tsutomu
T
Nakahara
Kenji
K
Sakamoto
Kunio
K
Ishii
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D008297:Male; D016202:N-Methylaspartate / Q000633:toxicity*; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D020258:Neurotoxicity Syndromes / Q000517:prevention & control*; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D020030:Nitric Oxide Donors / Q000009:adverse effects*; D009603:Nitroso Compounds / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012160:Retina / Q000187:drug effects* / Q000473:pathology; D012164:Retinal Diseases / Q000473:pathology / Q000517:prevention & control*
D000975:Antioxidants; D018690:Excitatory Amino Acid Agonists; C118603:NOC 12; D018696:Neuroprotective Agents; D020030:Nitric Oxide Donors; D009603:Nitroso Compounds; D016194:Receptors, N-Methyl-D-Aspartate; C035100:nilvadipine; D016202:N-Methylaspartate; D009543:Nifedipine