A graphene oxide and exonuclease-aided amplification immuno-sensor for antigen detection.
We have developed a novel immuno-sensor applied to protein detection based on exonuclease III (Exo III)-induced signal amplification, multiplex binding of the biotin-streptavidin system and the fluorescence quenching ability of graphene oxide.
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, P. R. China. zhkhe@whu.edu.cn.
Yufei
Y
Liu
Ming
M
Luo
Xia
X
Xiang
Chaohui
C
Chen
Xinghu
X
Ji
Lu
L
Chen
Zhike
Z
He
D000941:Antigens / Q000032:analysis*; D001681:Biological Assay; D005090:Exodeoxyribonucleases / Q000737:chemistry*; D006108:Graphite / Q000737:chemistry*; D057230:Limit of Detection; D010087:Oxides / Q000737:chemistry*; D000509:alpha-Fetoproteins / Q000737:chemistry
D000941:Antigens; D010087:Oxides; D000509:alpha-Fetoproteins; D006108:Graphite; D005090:Exodeoxyribonucleases; C020133:exodeoxyribonuclease III