From observational to dynamic genetics.
Twin and family studies have shown that most traits are at least moderately heritable. But what are the implications of finding genetic influence for the design of intervention and prevention programs? For complex traits, heritability does not mean immutability, and research has shown that genetic influences can change with age, context, and in response to behavioral and drug interventions. The most significant implications for intervention will come when we move from observational genetics to investigating dynamic genetics, including genetically sensitive interventions. Future interventions should be designed to overcome genetic risk and draw upon genetic strengths by changing the environment.
Department of Psychology, University of Warwick Coventry, UK.
Claire M A
CM
Haworth
Department of Genetics, Evolution and Environment, UCL Genetics Institute, University College London London, UK.
Oliver S P
OS
Davis
Twins; dynamic genetics; gene-environment interaction; heritability; intervention