Solid self-nanoemulsifying drug delivery system (S-SNEDDS) for oral delivery of glimepiride: development and antidiabetic activity in albino rabbits.
BACKGROUND
This study presents novel self-nanoemulsifying drug delivery system potential of oral delivering which leads poorly aqueous soluble drug glimepiride.


OBJECTIVE
The objective of this study was to prepare solid self-nanoemulsifying drug delivery system (S-SNEDDS) for the improved oral delivery of glimepiride and to evaluate its therapeutic efficacy in albino rabbits.


CONCLUSIONS
The droplet size analyses revealed a droplet size of less than 200 nm. The solid state characterization of S-SNEDDS by scanning electron microscopy (SEM), X-ray powder diffraction and differential scanning calorimetry (DSC) revealed the absence of crystalline glimepiride in the S-SNEDDS. The in vitro dissolution studies revealed that the significant improvement in glimepiride release characteristics. The effect of S-SNEDDS on therapeutic efficacy of glimepride was assessed in albino rabbits by monitoring blood glucose levels and compared with free drug suspension, L-SNEDDS. The S-SNEDDS showed significant (p < 0.05) increase in in vitro drug release and therapeutic efficacy as compared with free drug.


CONCLUSIONS
This study demonstrated that S-SNEDDS is a promising novel drug delivery system of glimepride to enhance oral delivery.
Department of Pharmaceutics, School of Pharmacy, Anurag Group of Institutions , Hyderabad, Andhra Pradesh , India and.
Abdul Bari
AB
Mohd
Krishna
K
Sanka
Srikanth
S
Bandi
Prakash V
PV
Diwan
Nalini
N
Shastri
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D002152:Calorimetry, Differential Scanning; D016503:Drug Delivery Systems; D065546:Drug Liberation; D004655:Emulsions; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011817:Rabbits; D012995:Solubility; D013453:Sulfonylurea Compounds / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D014961:X-Ray Diffraction
D001786:Blood Glucose; D004655:Emulsions; D007004:Hypoglycemic Agents; D013453:Sulfonylurea Compounds; C057619:glimepiride
Aerosol 200; S-SNEDDS; dissolution; glimepiride; oral delivery; solid carrier