To drive or be driven: the path of a mouse model of recurrent pregnancy loss.
This review is an example of the use of an animal model to try to understand the immune biology of pregnancy. A well-known model of recurrent spontaneous pregnancy loss is put in clinical, historical, and theoretical context, with emphasis on T cell biology.
Division of Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont College of Medicine, Given Building, 89 Beaumont Avenue, Burlington, Vermont 05404, USA.
Elizabeth A
EA
Bonney
Stephen A
SA
Brown
D000026:Abortion, Habitual / Q000276:immunology* / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007107:Immune System / Q000276:immunology / Q000502:physiology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000276:immunology* / Q000502:physiology; D008811:Mice, Inbred DBA / Q000276:immunology* / Q000502:physiology; D010641:Phenotype; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000276:immunology* / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000502:physiology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000502:physiology