Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process.
The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes genotype-based drug guidelines to help clinicians understand how available genetic test results could be used to optimize drug therapy. CPIC has focused initially on well-known examples of pharmacogenomic associations that have been implemented in selected clinical settings, publishing nine to date. Each CPIC guideline adheres to a standardized format and includes a standard system for grading levels of evidence linking genotypes to phenotypes and assigning a level of strength to each prescribing recommendation. CPIC guidelines contain the necessary information to help clinicians translate patient-specific diplotypes for each gene into clinical phenotypes or drug dosing groups. This paper reviews the development process of the CPIC guidelines and compares this process to the Institute of Medicine's Standards for Developing Trustworthy Clinical Practice Guidelines.
Kelly E
KE
Caudle
Teri E
TE
Klein
James M
JM
Hoffman
Daniel J
DJ
Muller
Michelle
M
Whirl-Carrillo
Li
L
Gong
Ellen M
EM
McDonagh
Katrin
K
Sangkuhl
Caroline F
CF
Thorn
Matthias
M
Schwab
Jose A G
JA
Agundez
Robert R
RR
Freimuth
Vojtech
V
Huser
Ming Ta Michael
MT
Lee
Otito F
OF
Iwuchukwu
Kristine R
KR
Crews
Stuart A
SA
Scott
Mia
M
Wadelius
Jesse J
JJ
Swen
Rachel F
RF
Tyndale
C Michael
CM
Stein
Dan
D
Roden
Mary V
MV
Relling
Marc S
MS
Williams
262 Danny Thomas Place MS: 313, Memphis, TN 38105, USA. cpic@pharmgkb.org.
Samuel G
SG
Johnson
D005820:Genetic Testing / Q000379:methods*; D005838:Genotype; D006801:Humans; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010597:Pharmacogenetics / Q000379:methods*; D010641:Phenotype; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians'
D004364:Pharmaceutical Preparations