Maternal grafts protect daughter recipients from acute cellular rejection after pediatric living donor liver transplantation for biliary atresia.
Some studies have found that gender mismatch between donors and recipients are related to poor graft prognosis after liver transplantation. However, few studies have investigated the impact of gender mismatch on acute cellular rejection (ACR) in pediatric living donor liver transplantation (LDLT). This retrospective study investigated the clinical significance of these factors in ACR after pediatric LDLT. Between November 2001 and February 2012, 114 LDLTs were performed for recipients with biliary atresia (BA) using parental grafts. We performed univariate and multivariate analyses to identify the factors associated with ACR. The donor-recipient classifications included mother donor to daughter recipient (MD; n = 43), mother to son (n = 18), father to daughter (FD; n = 33), and father to son (n = 20) groups. The overall incidence rate of ACR in the recipients was 36.8%. Multivariate analysis showed that gender mismatch alone was an independent risk factor for ACR (P = 0.012). The FD group had a higher incidence of ACR than the MD group (P = 0.002). In LDLT, paternal grafts with gender mismatch were associated with a higher increased incidence of ACR than maternal grafts with gender match. Our findings support the possibility that maternal antigens may have an important clinical impact on graft tolerance in LDLT for patients with BA.
Department of Transplant Surgery, Jichi Medical University, Shimotsuke City, Japan; Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Yukihiro
Y
Sanada
Youichi
Y
Kawano
Atsushi
A
Miki
Junko
J
Aida
Ken-ichi
K
Nakamura
Naotaka
N
Shimomura
Naoshi
N
Ishikawa
Tomio
T
Arai
Yuta
Y
Hirata
Naoya
N
Yamada
Noriki
N
Okada
Taiichi
T
Wakiya
Yoshiyuki
Y
Ihara
Taizen
T
Urahashi
Yoshikazu
Y
Yasuda
Kaiyo
K
Takubo
Koichi
K
Mizuta
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001656:Biliary Atresia / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005220:Fathers; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007223:Infant; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D009035:Mothers; D012189:Retrospective Studies; D012307:Risk Factors; D012727:Sex Characteristics; D055815:Young Adult
acute cellular rejection; biliary atresia; gender; parental donor; pediatric living donor liver transplantation