[Use propensity score method to analyze data about effectiveness of coronary heart disease treated by kudiezi injection].
OBJECTIVE
Real world clinical research to evaluate the effect on coronary heart disease (CHD) of parenterally administered Kudiezi.


METHODS
Eighteen nationwide general hospitals' hospital information systems (HIS) were searched for information on in patients treated with parenterally administered Kudiezi. Evaluation used generalized boosted models (GBM), and three types of logistic regression based on adjusted propensity score to balance confounding factors.


RESULTS
Two groups of coronary heart patients were compared, one group received parenterally administered Kudiezi and one did not. Seventy two confounding factors were identified and balanced by GBM. The three methods of logistic regression demonstrated that patients receiving parenterally administered Kudiezi had improved outcomes compared to those who did not receive the drug and this was statistically significant.


CONCLUSIONS
Parenterally administered Kudiezi is a potential adjuvant therapy in the treatment of coronary heart disease. Logistic regression based on adjusted propensity score can balance confounding factors in retrospective data analysis. However it's limitation is that it is not applicable in prospective studies.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. okfrom2008@hotmail.com
Xing
X
Liao
School of Statistics, Renmin University of China, Beijing 100872, China.
Xian-Bin
XB
Zeng
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yan-Ming
YM
Xie
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Wei
W
Yang
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Wei
W
Yang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000188:drug therapy* / Q000401:mortality; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D006751:Hospital Information Systems / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D064792:Pragmatic Clinical Trials as Topic; D057216:Propensity Score; D016896:Treatment Outcome; D055815:Young Adult
D004365:Drugs, Chinese Herbal