Antihyperglycemic glucosylated coumaroyltyramine derivatives from Teucrium viscidum.
Eight new glucosylated coumaroyltyramine derivatives, teuvissides A-H (1-8), were isolated from whole plants of Teucrium viscidum. Their structures were elucidated using spectroscopic data and chemical methods. The antihyperglycemic activities of these compounds were evaluated in HepG2 cells and 3T3-L1 adipocytes, and all of the isolates elicited different levels of glucose consumption at a concentration of 2.0 μM. Teuvissides A (1), B (2), and F (6) induced 2.2-, 2.1-, and 2.2-fold changes, respectively, in the levels of glucose consumption in HepG2 cells and 2.5-, 2.1-, and 2.3-fold changes, respectively, in 3T3-L1 adipocytes relative to the basal levels.
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, China Pharmaceutical University , 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China.
Hua-Wei
HW
Lv
Meng-Di
MD
Zhu
Jian-Guang
JG
Luo
Ling-Yi
LY
Kong
D017667:Adipocytes / Q000187:drug effects; D000818:Animals; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005947:Glucose / Q000031:analogs & derivatives / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D056945:Hep G2 Cells; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031367:Teucrium / Q000737:chemistry*; D014439:Tyramine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D007004:Hypoglycemic Agents; D007328:Insulin; C000590034:teuvisside A; C000590035:teuvisside B; C000590036:teuvisside F; D005947:Glucose; D014439:Tyramine