Polygonumosides A-D, stilbene derivatives from processed roots of Polygonum multiflorum.
Four new stilbene derivatives, polygonumosides A-D (1-4), were isolated from the processed roots of Polygonum multiflorum. Their structures were elucidated by spectroscopic analysis, including 1D and 2D NMR and ECD. Polygonumosides A (1) and B (2), possessing an unprecedented tetracyclic skeleton, were assigned as 2S- and 2R-2-(4-hydroxyphenyl)-9,10,11-trihydroxy-2H-benzo[c]furo[2,3-f]chromen-7(3H)-one-4-O-β-d-glucopyranosides, respectively, while polygonumosides C (3) and D (4) were assigned as a pair of diastereomeric stilbene glucoside dimers.
Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science & Technology, Tianjin University , Tianjin 300072, People's Republic of China.
Shi-Lun
SL
Yan
Yan-Fang
YF
Su
Lei
L
Chen
Meng
M
Que
Xiu-Mei
XM
Gao
Jun-Biao
JB
Chang
D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D028502:Polygonum / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification*
C489707:2',3',4',5'-tetrahydroxystilbene-2-O-beta-D-glucoside; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D013267:Stilbenes