Synthesis of multi-substituted pyrroles using enamides and alkynes catalyzed by Pd(OAc)2 with molecular oxygen as an oxidant.
A cyclization reaction between enamides and alkynes catalyzed by palladium(II) acetate is described. In this method, the molecular oxygen serves as an efficient oxidant for the Pd(II)/Pd(0) catalytic cycle. The simple reaction conditions permit this methodology to be used as a general tool for the preparation of multi-substituted pyrroles.
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P.R. China. teckpeng@ntu.edu.sg.
Yun-He
YH
Xu
Tao
T
He
Qiu-Chi
QC
Zhang
Teck-Peng
TP
Loh
D000085:Acetates / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D016877:Oxidants / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis*
D000085:Acetates; D000480:Alkynes; D000577:Amides; D016877:Oxidants; D011758:Pyrroles; D010165:Palladium; D010100:Oxygen