Components of foods inhibit a drug exporter, human multidrug and toxin extrusion transporter 1.
Human multidrug and toxic compounds extrusion transporter 1 (hMATE1/SLC47A1) is a H(+)-coupled organic cation exporter responsible for the final step of excretion of various xenobiotics at the kidney and liver. In this study, effects of dietary constituents on hMATE1 mediated drug transport were examined to evaluate possible food-drug interactions. Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a Ki of 98.7 µM. Coumarins, flavonols, and catechin inhibited hMATE1 activity. Among 23 compounds tested, isorhamnetin was the strongest inhibitor of hMATE1 with the Ki of 0.32 µM in a competitive manner. Since isorhamnetin is abundant in Ginkgo biloba that is widely used for herbal supplements, the findings suggest the potential hMATE1 related food-drug interactions.
Department of Membrane Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
Tatsuya
T
Kawasaki
Hideyuki
H
Ito
Hiroshi
H
Omote
D001692:Biological Transport; D001693:Biological Transport, Active; D002412:Cations / Q000378:metabolism; D002460:Cell Line; D004032:Diet; D018565:Food-Drug Interactions; D011564:Furocoumarins / Q000494:pharmacology; D020441:Ginkgo biloba / Q000737:chemistry; D057809:HEK293 Cells; D041743:Herb-Drug Interactions; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D027701:Organic Cation Transport Proteins / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000494:pharmacology*; D011522:Protons; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D019789:Tetraethylammonium / Q000378:metabolism*; D015262:Xenobiotics / Q000378:metabolism
D002412:Cations; D011564:Furocoumarins; D027701:Organic Cation Transport Proteins; D010936:Plant Extracts; D011522:Protons; D015262:Xenobiotics; C047368:3-methylquercetin; D019789:Tetraethylammonium; D011794:Quercetin; C068337:bergamottin