[Correlation of VEGF expression with microvessel and microlymphatic density in sinonasal squamous cell carcinoma].
OBJECTIVE
To study the expression of VEGF in sinonasal squamous cell carcinoma and its correlations with microvessel density (MVD), microlymphatic vessel density (MLVD).


METHODS
The expression of VEGF, MVD and MLVD in 41 cases of sinonasal squamous cell carcinoma were detected by immunohistochemical technique.


RESULTS
In the sinonasal squamous cell carcinoma, the positive rate of VEGF was 82.9% (34/41). The over expression of VEGF was related with tumor invasion, histological grading and lymphatic metastasis (P < 0.05). The MVD of cases with positive VEGF expression was significantly higher than those without VEGF expression (P < 0.05), but was not statistical difference in MLVD (P > 0.05).


CONCLUSIONS
VEGF may participate in the metastasis of sinonasal squamous cell carcinoma through promoting vascularization in the tumors, but not promoting MLVD.
Department of Otolaryngology, First People's Hospital of Shunde City Affiliated to Southern Medical University, Shunde 528300, China. damaodoctor@126.com
Zhi
Z
Tang
Department of Otolaryngology, First Affiliated Hospital of Zhengzhou University, China.
Jin
J
Sun
Department of Otolaryngology, First People's Hospital of Shunde City Affiliated to Southern Medical University, Shunde 528300, China.
Jiqun
J
Wang
Department of Otolaryngology, First People's Hospital of Shunde City Affiliated to Southern Medical University, Shunde 528300, China.
Yulan
Y
Li
Department of Otolaryngology, First People's Hospital of Shunde City Affiliated to Southern Medical University, Shunde 528300, China.
Yongming
Y
Chen
Department of Otolaryngology, First People's Hospital of Shunde City Affiliated to Southern Medical University, Shunde 528300, China.
Zhifeng
Z
Tu
D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D055806:Microvessels; D009296:Nasal Cavity; D009389:Neovascularization, Pathologic; D009669:Nose Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A