Nickel-catalyzed C-H alkylations: direct secondary alkylations and trifluoroethylations of arenes.
A versatile nickel catalyst allowed for C-H alkylations of unactivated arenes with challenging secondary alkyl bromides and chlorides. The high catalytic efficacy also set the stage for direct secondary alkylations of indoles as well as C-H trifluoroethylations with ample substrate scope.
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität, Tammannstrasse 2, 37077 Göttingen (Germany) http://www.org.chemie.uni-goettingen.de/ackermann/
Weifeng
W
Song
Sebastian
S
Lackner
Lutz
L
Ackermann
CH activation; auxiliary assistance; nickel; secondary alkylation; trifluoroethylation