[Coagulation therapy in multiple trauma without point-of-care testing].
Analysis of blood coagulation with thrombelastometry (ROTEM™) and thrombelastography (TEG™) and analysis of thrombocyte function by a Multiplate™ assay is possible in only a few hospitals in Germany. Recently, the grade of recommendation (GoR) for point-of-care (POC) testing in official guidelines was increased and is now classified as GoR 1C. If a POC-based option is not available alternatives must be used. Besides blood products (RBC, FFP, TC), coagulation factor concentrates are used to treat trauma-induced coagulopathy. The benefits of therapy with factor concentrates are fewer immunological and infection side effects as well as faster effects after administration of specific coagulation factors. A good outcome in patients with multiple trauma is only possible by an adequate transfusion regime and administration of coagulation factors.
Klinik für Anästhesiologie und Operative Intensivmedizin, Universitätsklinikum Köln (AöR), Kerpener Straße 62, 50937, Köln, Deutschland, Heiko.Lier@uk-koeln.de.
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D001778:Blood Coagulation Disorders / Q000209:etiology* / Q000628:therapy*; D001779:Blood Coagulation Factors / Q000627:therapeutic use*; D001780:Blood Coagulation Tests / Q000379:methods*; D016913:Blood Component Transfusion / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods; D004632:Emergency Medical Services / Q000379:methods; D006801:Humans; D009104:Multiple Trauma / Q000150:complications* / Q000628:therapy*; D019095:Point-of-Care Systems
D001779:Blood Coagulation Factors