JAK2-STAT5B pathway and osteoblast differentiation.
Osteoblast differentiation is a critical step in the maintenance of bone homeostasis. Osteoblast differentiation is generally maintained by growth hormone (GH) and various other endocrine and autocrine/paracrine factors. JAK2-STAT5B pathway is a central axis in the mechanism of GH signaling. Similarly, the autocrine/paracrine signaling factor IGF-1 also mediates its effects through this pathway. Analysis on JAK2-STAT5B pathway showed its importance in the IGF-1/IGF-1R mediated regulation of gene expression and osteoblast differentiation. Persistent activation of STAT5B and inhibition of STAT5B degradation showed increased osteoblastic differentiation and STAT5B/Runx-2 activities. Conditional gene silencing studies showed the importance of the JAK2-STAT5B pathway in stimulation of other transcription factors and expression of various differentiation markers.
Department of Pathology; School of Medicine; and Institute of Biomedical Science and Technology; Konkuk University; Seoul, Republic of Korea.
Pramod
P
Darvin
Department of Pathology; School of Medicine; and Institute of Biomedical Science and Technology; Konkuk University; Seoul, Republic of Korea.
Youn Hee
YH
Joung
Department of Pathology; School of Medicine; and Institute of Biomedical Science and Technology; Konkuk University; Seoul, Republic of Korea.
Young Mok
YM
Yang
BMPs; IGF-1R; JAK2-STAT5B; growth hormone receptor; osteoblast differentiation