Copper-mediated cross-coupling-cyclization-oxidation: a one-pot reaction to construct polysubstituted pyrroles.
A novel and efficient procedure for the synthesis of polysubstituted pyrroles has been developed in this work. The polysubsituted pyrroles were synthesized directly from terminal alkenes, amines and β-keto esters through cross-coupling-cyclization-oxidation in the presence of a catalytic amount of cuprous chloride. This method provides a one-pot synthesis route from terminal alkenes to polysubstituted pyrroles for the first time and opens a new area in cuprous catalysis.
Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), School of Chemistry & Chemical Engineering of Guangxi Normal University, Guilin 541004, People's Republic of China. panym2013@hotmail.com chenzfubc@yahoo.com.
Pei
P
Liu
Jin-ling
JL
Liu
Heng-shan
HS
Wang
Ying-ming
YM
Pan
Hong
H
Liang
Zhen-Feng
ZF
Chen
D002384:Catalysis; D003300:Copper / Q000737:chemistry* / Q000378:metabolism*; D018360:Crystallography, X-Ray; D003500:Cyclization / Q000502:physiology; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000138:chemical synthesis* / Q000378:metabolism*
D011758:Pyrroles; D003300:Copper; C028419:cuprous chloride