[Effect of paclitaxel on platelet aggregation induced by adenosine diphosphate in vitro].
OBJECTIVE
To investigate the effect of paclitaxel on platelet aggregation induced by adenosine diphosphate (ADP) in vitro.


METHODS
Platelet suspension was incubated with paclitaxel in different concentrations (0 ng/mL, 0.01 ng/mL, 0.1 ng/mL, 1 ng/mL, 10 ng/mL, 100 ng/mL, 1 000 ng/mL), then the maximal extent of platelet aggregation was determined under the conditions of the best ADP concentration and the best incubation time.


RESULTS
Under the condition of 10 micromol/L ADP and incubated for 10 min, with the increase of paclitaxel concentration, the effect of paclitaxel on platelet aggregation induced by ADP elevated accordingly, and the differences among the different concentration groups were statistically significant (P < 0.05).


CONCLUSIONS
Paclitaxel can enhance ADP-induced platelet aggregation in a concentration-dependent manner in vitro.
Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, China.
Shu
S
Zhang
Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, China.
Chang-Li
CL
Sun
Department of Emergency, West China Hospital, Sichuan University, Chengdu 610041, China.
Hu
H
Nie
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D004357:Drug Synergism; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D055815:Young Adult
D000244:Adenosine Diphosphate; D017239:Paclitaxel