Driving nucleolar assembly.
In this issue of Genes & Development, Grob and colleagues (pp. 220-230) identify the minimal molecular requirements to assemble a fully functional nucleolus in human cells and demonstrate the importance of the nucleolar transcription factor upstream binding factor (UBF) as a mitotic bookmark at the ribosomal DNA (rDNA).
Department of Genetics.
Kathleen L
KL
McCann
Susan J
SJ
Baserga
D000818:Animals; D058045:Artificial Cells / Q000378:metabolism*; D002455:Cell Division / Q000502:physiology*; D002466:Cell Nucleolus / Q000378:metabolism*; D006801:Humans
UBF; mitotic bookmarking; neo-NOR; nucleolar organizer region (NOR); nucleolus; pseudo-NOR