A unique combined source of "CN" from 1,2-dichloroethane and TMSN3 in the copper-catalyzed cyanation of a C(sp3)-H bond adjacent to a nitrogen atom.
A novel combined metal-free "CN" source from trimethylsilyl azide and 1,2-dichloroethane has been developed and successfully applied to copper-catalyzed oxidative cyanation of α-C-H tertiary amines for the synthesis of C1-cyanation tetrahydroisoquinoline derivatives with good to excellent yields for the first time.
School of Chemical Engineering, Nanjing University of Science, Technology , Nanjing 210000, China.
Gen
G
Zhang
Yunxia
Y
Ma
Guangbin
G
Cheng
Dabin
D
Liu
Rui
R
Wang
D003300:Copper / Q000737:chemistry*; D005025:Ethylene Dichlorides / Q000737:chemistry*; D006860:Hydrogen Bonding; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis*; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D005025:Ethylene Dichlorides; D007546:Isoquinolines; D009570:Nitriles; C024565:ethylene dichloride; D003300:Copper; D009584:Nitrogen