Evolving protein-protein interaction networks: A model based on duplication and mutation at different rates.
We present a model describing the evolution of protein-protein interaction networks. The model is based on gene duplication and mutation. Considering rates of gene duplication and mutation, the average node degree and cluster coefficient are calculated for different parameters. The predicted degree distribution and cluster coefficient are in good agreement with the observed statistical properties obtained from the analysis of the yeast proteome.
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Jin-Tu
JT
Sun
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Bin
B
Ao
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Sheng
S
Zhang
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Zhitong
Z
Bing
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China. Electronic address: lyang@impcas.ac.cn.
Lei
L
Yang
D019143:Evolution, Molecular; D020440:Gene Duplication; D008957:Models, Genetic; D009154:Mutation / Q000235:genetics*; D059645:Mutation Rate; D060066:Protein Interaction Maps; D020543:Proteome / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
D020543:Proteome; D029701:Saccharomyces cerevisiae Proteins
Evolution; Genome; Yeast