One size fits one: pharmacogenetics in gastroenterology.
Individual variability in response and development of adverse effects to drugs is a major challenge in clinical practice. Pharmacogenomics refers to the aspect of personalized medicine where the patient's genetic information instructs the selection and dosage of therapy while also predicting its adverse effects profile. Sequencing of the entire human genome has given us the opportunity to study commonly used drugs as well as newer therapeutic agents in a new light, opening up opportunities for better drug efficacy and decreased adverse effects. This article highlights developments in pharmacogenomics, relates these to practice of gastroenterology, and outlines roadblocks in translation of this knowledge into clinical practice.
Division of Pediatric Gastroenterology/Hepatology/Nutrition, Riley Hospital for Children/Indiana University School of Medicine, Indianapolis, Indiana.
Prashanth
P
Porayette
Division of Clinical Pharmacology, Department of Medicine, Riley Hospital for Children/Indiana University School of Medicine, Indiana Institute for Personalized Medicine, Indianapolis, Indiana.
David
D
Flockhart
Division of Pediatric Gastroenterology/Hepatology/Nutrition, Riley Hospital for Children/Indiana University School of Medicine, Indianapolis, Indiana. Electronic address: sgupta@iu.edu.
Sandeep K
SK
Gupta
D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology; D005762:Gastroenterology / Q000379:methods* / Q000639:trends; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006801:Humans; D007206:Individuality; D010597:Pharmacogenetics / Q000379:methods* / Q000639:trends; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D016896:Treatment Outcome
D005765:Gastrointestinal Agents
Gastroenterology; Personalized Medicine; Pharmacogenetics