Correlation between radiation dose and histopathological findings in patients with gliblastoma treated with boron neutron capture therapy (BNCT).
The purpose of this study was to clarify the correlation between the radiation dose and histopathological findings in patients with glioblastoma multiforme (GBM) treated with boron neutron capture therapy (BNCT). Histopathological studies were performed on specimens from 8 patients, 3 had undergone salvage surgery and 5 were autopsied. For histopathological cure of GBM at the primary site, the optimal minimal dose to the gross tumor volume (GTV) and the clinical target volume (CTV) were 68Gy(w) and 44Gy(w), respectively.
Department of Neurosurgery, The University of Tokushima, Tokushima 770-8503, Japan. Electronic address: kageji@clin.med.tokushima-u.ac.jp.
T
T
Kageji
Department of Neurosurgery, The University of Tokushima, Tokushima 770-8503, Japan.
Y
Y
Mizobuchi
Department of Neurosurgery, The University of Tokushima, Tokushima 770-8503, Japan.
S
S
Nagahiro
Department of Neurosurgery, Kagawa National Children's Hospital, Kagawa, Japan.
Y
Y
Nakagawa
Department of Radiation Oncology, Graduate School of Comprehensive Human Science, University of Tsukuba, Ibaragi, Japan.
H
H
Kumada
D001894:Borohydrides / Q000627:therapeutic use*; D001896:Boron Compounds / Q000627:therapeutic use*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D001932:Brain Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D005909:Glioblastoma / Q000473:pathology* / Q000532:radiotherapy*; D006801:Humans; D018365:Neoplasm, Residual / Q000473:pathology / Q000517:prevention & control; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D013223:Statistics as Topic; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*; D015996:Survival Rate; D016896:Treatment Outcome
C436045:4-dihydroxyborylphenylalanine; D001894:Borohydrides; D001896:Boron Compounds; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D010649:Phenylalanine
BNCT; Glioblatoma; Radiation