Alistonitrine A, a caged monoterpene indole alkaloid from Alstonia scholaris.
Alistonitrine A, a new monoterpene indole alkaloid incorporating a third nitrogen atom, was isolated from the leaves of Alstonia scholaris and found to possess an unprecedented caged skeleton with a unique 6/5/6/5/5/6 ring system. Its structure and absolute configuration were established by extensive spectroscopic analyses and electron circular dichroism calculations. A plausible biogenetic pathway has been proposed for the biosynthesis of alistonitrine A from picrinine.
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology , Taipa, Macau, China.
Guo-Yuan
GY
Zhu
Xiao-Jun
XJ
Yao
Liang
L
Liu
Li-Ping
LP
Bai
Zhi-Hong
ZH
Jiang
D031051:Alstonia / Q000737:chemistry*; D026121:Indole Alkaloids / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D046948:Secologanin Tryptamine Alkaloids / Q000737:chemistry* / Q000302:isolation & purification*
D026121:Indole Alkaloids; D046948:Secologanin Tryptamine Alkaloids; C588339:alistonitrine A; C528220:picrinine