Association between APOC1 polymorphism and Alzheimer's disease: a case-control study and meta-analysis.
BACKGROUND
Previous association studies examining the relationship between the APOC1 polymorphism and susceptibility to Alzheimer's disease (AD) have shown conflicting results, and it is not clear if an APOC1 variant acts as a genetic risk factor in AD etiology across multiple populations.


METHODS
To confirm the risk association between APOC1 and AD, we designed a case-control study and also performed a meta-analysis of previously published studies.


RESULTS
Seventy-nine patients with AD and one hundred fifty-six unrelated controls were included in case-control study. No association was found between the variation of APOC1 and AD in stage 1 of our study. However, our meta-analysis pooled a total of 2092 AD patients and 2685 controls. The APOC1 rs11568822 polymorphism was associated with increased AD risk in Caucasians, Asians and Caribbean Hispanics, but not in African Americans. APOE ε4 carriers harboring the APOC1 insertion allele, were more prevalent in AD patients than controls (χ(2) = 119.46, OR = 2.79, 95% CI = 2.31-3.36, P<0.01).


CONCLUSIONS
The APOC1 insertion allele, in combination with APOE ε4, likely serves as a potential risk factor for developing AD.
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China ; Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Qin
Q
Zhou
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Fan
F
Zhao
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Ze-ping
ZP
Lv
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Chen-guang
CG
Zheng
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Wei-dong
WD
Zheng
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Liang
L
Sun
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Na-na
NN
Wang
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Shenghang
S
Pang
Health Science Institute, Universidade Feevale, Novo Hamburgo, Rio Grande do Sul, Brazil.
Fabiana Michelsen
FM
de Andrade
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Mian
M
Fu
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Xiang-hua
XH
He
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Juan
J
Hui
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
WenyYu
W
Jiang
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Chu-yu
CY
Yang
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Xiao-hong
XH
Shi
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Xiao-quan
XQ
Zhu
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Guo-fang
GF
Pang
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Yi-ge
YG
Yang
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Hai-qun
HQ
Xie
Institutes for Biological Sciences, National Research Council of Canada, Ottawa, Canada.
Wan-dong
WD
Zhang
Department of Neurology, Jiangbin hospital, Guangxi Zhuang Autonomous Region, Nanning, China.
Cai-you
CY
Hu
The Key Laboratory of Geriatrics, Beijing Hospital & Beijing Institute of Geriatrics, Ministry of Health, Beijing, China.
Ze
Z
Yang
D000368:Aged; D006801:Humans; D000544:Alzheimer Disease / Q000208:ethnology / Q000235:genetics; D053302:Apolipoprotein C-I / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics; D044466:Asian People / Q000235:genetics; D001741:Black or African American / Q000235:genetics; D016022:Case-Control Studies; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics; D016014:Linear Models; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
C505803:APOC1 protein, human; D053302:Apolipoprotein C-I; D053327:Apolipoprotein E4