Non-CpG hypermethylation in placenta of mutation-induced intrauterine growth restricted bovine foetuses.
The existence of non-CpG methylation in mammalian DNA has mainly been observed in embryonic stem cells, but its functional significance is uncertain. We found an age-dependent non-CpG hypermethylation in DMR at the 3' end of the MIMT1 in the placenta of intrauterine growth restricted foetuses in cattle. Data suggest that this DMR play a role in epigenetic regulation of the PEG3 domain.
Department of Production Animal Medicine, University of Helsinki, Saarentaus, Finland.
Heli
H
Venhoranta
Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
Shun
S
Li
Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637 Poznan, Poland.
Sylwia
S
Salamon
Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
Tatiana
T
Flisikowska
Department of Production Animal Medicine, University of Helsinki, Saarentaus, Finland.
Magnus
M
Andersson
Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, 60-637 Poznan, Poland.
Marek
M
Switonski
Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
Alexander
A
Kind
Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany.
Angelika
A
Schnieke
Chair of Livestock Biotechnology, Technische Universität München, Freising, Germany. Electronic address: flisikowski@wzw.tum.de.
Krzysztof
K
Flisikowski
D000818:Animals; D001483:Base Sequence; D002417:Cattle; D018899:CpG Islands; D019175:DNA Methylation; D017931:DNA Primers; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D009154:Mutation; D010920:Placenta / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011247:Pregnancy
D017931:DNA Primers
Epigenetic regulation; Intrauterine growth restriction; Mammalian DNA; Non-CpG methylation; PEG3