Manganese in health and disease.
Manganese is an important metal for human health, being absolutely necessary for development, metabolism, and the antioxidant system. Nevertheless, excessive exposure or intake may lead to a condition known as manganism, a neurodegenerative disorder that causes dopaminergic neuronal death and parkinsonian-like symptoms. Hence, Mn has a paradoxal effect in animals, a Janus-faced metal. Extensive work has been carried out to understand Mn-induced neurotoxicity and to find an effective treatment. This review focuses on the requirement for Mn in human health as well as the diseases associated with excessive exposure to this metal.
Biochemistry Graduation Program, Universidade Federal do Pampa, Uruguaiana, Rio Grande do Sul, Brazil, avilads1@gmail.com.
Daiana Silva
DS
Avila
Robson Luiz
RL
Puntel
Michael
M
Aschner
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D016923:Cell Death; D059290:Dopaminergic Neurons / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008345:Manganese / Q000378:metabolism*; D020149:Manganese Poisoning / Q000378:metabolism / Q000473:pathology; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000473:pathology
D000975:Antioxidants; D008345:Manganese