Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
The linker of nucleoskeleton and cytoskeleton (LINC) complex, composed of proteins within the inner and the outer nuclear membranes, connects the nuclear lamina to the cytoskeleton. The importance of this complex has been highlighted by the discovery of mutations in genes encoding LINC complex proteins, which cause skeletal or cardiac myopathies. Herein, this review summarizes structure, function, and interactions of major components of the LINC complex, highlights how mutations in these proteins may lead to cardiac disease, and outlines future challenges in the field.
From the Department of Cardiology, University of California San Diego School of Medicine, La Jolla, CA.
Matthew J
MJ
Stroud
Indroneal
I
Banerjee
Jennifer
J
Veevers
Ju
J
Chen
D000818:Animals; D003599:Cytoskeleton / Q000737:chemistry* / Q000473:pathology / Q000502:physiology*; D006331:Heart Diseases / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D032383:Myocytes, Cardiac / Q000737:chemistry / Q000473:pathology / Q000502:physiology*; D015530:Nuclear Matrix / Q000737:chemistry* / Q000473:pathology / Q000502:physiology*; D051179:Plakins / Q000737:chemistry* / Q000502:physiology*
D051179:Plakins
cardiomyopathies; cell nucleus; myocytes, cardiac