Effect of fructooligosaccharides fraction from Psacalium decompositum on inflammation and dyslipidemia in rats with fructose-induced obesity.
Psacalium decompositum, commonly known as "Matarique," is a medicinal plant used in Mexico for diabetes mellitus empirical therapy. Previous studies have shown that the fructooligosaccharides (FOS) present in the roots of this plant exhibit a notable hypoglycemic effect in animal models; this effect might be associated with the attenuation of the inflammatory process and other metabolic disorders. In this study, we examined the effects of FOS fraction administration in a fructose-fed rat model for obesity. Phytochemical chromatographic studies (high performance thin layer chromatography and nuclear magnetic resonance) were performed to verify isolation of FOS. 24 male Wistar rats were maintained for 12 weeks on a diet of 20% HFCS in drinking water and chow. Glucose, cholesterol, triglycerides and liver transaminases levels were measured monthly, after administering FOS fraction intragastrically (150 mg/kg/day for 12 weeks), while the levels of inflammatory cytokines were only quantified at the end of the treatments. Rats treated with FOS fraction decreased body weight, cholesterol, triglycerides, and significantly reduced IL-6, IFN-γ, MCP-1, IL-1β and VEGF levels (p < 0.05). These results suggest that P. decompositum has anti-inflammatory and hypolipidemic properties that might be used as an alternative treatment for the control of obesity.
Programa de Doctorado en Ciencias Biológicas y de la Salud. D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa, Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico. hmerino@ciencias.unam.mx.
Héctor
H
Merino-Aguilar
Instituto Politécnico Nacional-CNMN, Calle Luis Enrique Erro s/n, Unidad Profesional Adolfo López Mateos, Col. Zacatenco, México D.F. C.P. 07738, Mexico. danielarrieta@hotmail.com.
Daniel
D
Arrieta-Baez
Instituto de Química, Universidad Nacional Autónoma de México, Coyoacán, México D.F. C.P. 04510, Mexico. manueljemex@gmail.com.
Manuel
M
Jiménez-Estrada
Facultad de Medicina, Universidad Nacional Autónoma de México, Coyoacán, México D.F. C.P. 04510, Mexico. gamagos@unam.mx.
Gil
G
Magos-Guerrero
Programa de Doctorado en Biología Experimental, D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa, Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico. rjhb11@yahoo.com.mx.
René Javier
RJ
Hernández-Bautista
Programa de Doctorado en Biología Experimental, D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa, Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico. qfbsus@yahoo.com.mx.
Ana Del Carmen
Adel C
Susunaga-Notario
Departamento de Ciencias de la Salud, D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa, Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico. jcap@xanum.uam.mx.
Julio Cesar
JC
Almanza-Pérez
Departamento de Ciencias de la Salud, D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa, Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico. gera@xanum.uam.mx.
Gerardo
G
Blancas-Flores
Departamento de Ciencias de la Salud, D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa, Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico. rrr@xanum.uam.mx.
Rubén
R
Román-Ramos
Departamento de Ciencias de la Salud, D.C.B.S., Universidad Autónoma Metropolitana-Iztapalapa, Apdo-Postal 55-535, México D.F. C.P. 09340, Mexico. aaasj2@prodigy.net.mx.
Francisco Javier
FJ
Alarcón-Aguilar
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D001835:Body Weight; D018932:Chemokine CCL2 / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D050171:Dyslipidemias / Q000188:drug therapy*; D005632:Fructose / Q000009:adverse effects*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy*; D007371:Interferon-gamma / Q000097:blood; D053583:Interleukin-1beta / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009765:Obesity / Q000139:chemically induced / Q000188:drug therapy*; D009844:Oligosaccharides / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood
D000893:Anti-Inflammatory Agents; C491766:Ccl2 protein, rat; D018932:Chemokine CCL2; D007004:Hypoglycemic Agents; D053583:Interleukin-1beta; D015850:Interleukin-6; D009844:Oligosaccharides; D010936:Plant Extracts; D014280:Triglycerides; D042461:Vascular Endothelial Growth Factor A; C116580:fructooligosaccharide; C467498:vascular endothelial growth factor A, rat; D005632:Fructose; D007371:Interferon-gamma; D002784:Cholesterol