Xyloglucan-block-poly(ϵ-caprolactone) copolymer nanoparticles coated with chitosan as biocompatible mucoadhesive drug delivery system.
The development of novel xyloglucan-block-poly(ϵ-caprolactone) (XGO-b-PCL) nanoparticles coated with the mucoadhesive polysaccharide chitosan is described. XGO-b-PCL nanoparticles show monodisperse size distribution (Rh  = 50 nm). Curcumin is successfully encapsulated within the PCL core within drug to polymer ratio of 1:5 (w/w). The coating of nanoparticles with chitosan results in an increased particle size and positive surface charge due to the polycation nature of the chitosan. Mucoadhesive properties of chitosan-coated nanoparticles are demonstrated by its exceptional ability to interact with mucin through electrostatic forces. Finally, in vitro studies show that curcumin-loaded nanoparticles exhibit higher cytotoxic effects against B16F10 melanoma cells than L929 fibroblast cells.
Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Catarina (UFSC), Campus Universitário Trindade, 88040-900, Florianópolis, SC, Brazil.
Letícia
L
Mazzarino
Issei
I
Otsuka
Sami
S
Halila
Lorena dos Santos
Ldos S
Bubniak
Suelen
S
Mazzucco
Maria C
MC
Santos-Silva
Elenara
E
Lemos-Senna
Redouane
R
Borsali
D000269:Adhesives / Q000737:chemistry*; D017209:Apoptosis / Q000187:drug effects; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D005936:Glucans / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D020349:Surface Plasmon Resonance; D014990:Xylans / Q000737:chemistry*
D000269:Adhesives; D001672:Biocompatible Materials; D005936:Glucans; D011091:Polyesters; D014990:Xylans; C016240:polycaprolactone; C029353:xyloglucan; D048271:Chitosan; D003474:Curcumin
block copolymer nanoparticles; chitosan-coated nanoparticles; curcumin; cytotoxicity; mucoadhesive nanoparticles; polysaccharide coating