High levels of BCOX1 expression are associated with poor prognosis in patients with invasive ductal carcinomas of the breast.
This study was to examine the breast cancer-overexpressed gene 1 (BCOX1) expression in invasive ductal carcinomas (IDC) of the breast and its value in the prognosis of the disease. The levels of BCOX1 expression in 491 paired IDC and surrounding non-tumor breast tissues as well as 40 paired fresh specimens were evaluated by tissue microarray, immunohistochemistry and quantitative RT-PCR. The potential associations of high BCOX1 expression with clinicopathological variables and the overall survival of these patients were analyzed. The relative levels of BCOX1 mRNA transcripts in the IDC breast tissues were significantly higher than that in the corresponding non-tumor tissues (P = 0.005). The anti-BCOX1 was predominantly stained in the cytoplasm of breast tissue cells and the levels of BCOX1 expression in the majority of breast cancer tissues were obviously higher than that in the corresponding non-tumor breast tissues. High levels of BCOX1 expression were found in 59.5% (292/491) of breast cancer tissues. The high BCOX1 expression was significantly associated with high histological grade (P = 0.037), positive expression of human epidermal growth factor receptor 2 (HER2, P = 0.031) and triple negative breast cancer (P = 0.027). The high BCOX1 expression in breast cancers was significantly associated with a shorter overall survival of these patients (P = 0.023), particularly in patients with triple negative breast cancer (P = 0.005). Therefore, the high BCOX1 expression may serve as a novel marker of poor prognosis and a potential therapeutic target for patients with IDC of the breast.
Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Tong
T
Liu
Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Xian-Yu
XY
Zhang
Department of Medical Records, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Xiao-Hui
XH
He
Department of Pathology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin, China ; Department of Medical Genetics, Harbin Medical University, Harbin, China.
Jing-Shu
JS
Geng
Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Yang
Y
Liu
Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
De-Jia
DJ
Kong
Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Qing-Yu
QY
Shi
Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Feng
F
Liu
Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Wei
W
Wei
Department of Breast Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China.
Da
D
Pang
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000473:pathology*; D003710:Demography; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D016016:Proportional Hazards Models; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D064726:Triple Negative Breast Neoplasms / Q000235:genetics / Q000473:pathology
D009363:Neoplasm Proteins; D012333:RNA, Messenger; C510758:BLTP2 protein, human