[Biological diagnosis of pheochromocytoma in 2014].
Pheochromocytomas and/or paragangliomas are rare, heterogeneous tumors of the chromaffin cells. Thirty percent of the patients presented with these diseases in a hereditary context. The biological diagnosis relies on the identification of excessive secretion of the metanephrines which are more sensitive and specific than those of catecholamines. The published recommendations give the opportunity to choose between the metanephrines in sera or urines. The concentrations of the free plasmatic metanephrines reflect the ongoing production of tumor. They are little sensitive to the renal failure. The gold standard method to measure the free metaphrines in plasma is the LC-MS/MS chromatography. This is the technical event that we use since 2008, and we relate our experience.
Centre de biologie-pathologie-génétique, CHRU, Lille, France.
Nathalie
N
Rouaix-Emery
Centre de biologie-pathologie-génétique, CHRU, Lille, France.
Catherine
C
Tierny-Fontalirand
Clinique d'endocrinologie Marc Linquette, Hôpital Huriez, CHRU Lille, France.
Catherine
C
Cardot-Bauters
Clinique de chirurgie endocrinienne, CHRU Lille, France, Université de Lille 2, France.
Bruno
B
Carnaille
Clinique d'endocrinologie Marc Linquette, Hôpital Huriez, CHRU Lille, France, Université de Lille 2, France.
Jean-Louis
JL
Wemeau
Centre de biologie-pathologie-génétique, CHRU, Lille, France, Université de Lille 2, France.
Michèle
M
d'Herbomez
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D001774:Blood Chemical Analysis; D002395:Catecholamines / Q000502:physiology; D019411:Clinical Laboratory Techniques / Q000379:methods* / Q000639:trends; D005602:France / Q000453:epidemiology; D006801:Humans; D010235:Paraganglioma / Q000175:diagnosis; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D016482:Urinalysis
D002395:Catecholamines
mass spectrometry; metanephrines; paraganglioma; pheochromocytoma