Relationship between physical activity and plasma fibrinogen concentrations in adults without chronic diseases.
OBJECTIVE
To analyze the relationship between regular physical activity, as assessed by accelerometer and 7-day physical activity recall (PAR), and plasma fibrinogen concentrations.


METHODS
A cross-sectional study in a previously established cohort of healthy subjects was performed. This study analyzed 1284 subjects who were included in the EVIDENT study (mean age 55.0±13.6 years; 60.90% women). Fibrinogen concentrations were measured in blood plasma. Physical activity was assessed with a 7-day PAR (metabolic equivalents (METs)/hour/week) and GT3X ActiGraph accelerometer (counts/minute) for 7 days.


RESULTS
Physical exercise, which was evaluated with both an accelerometer (Median: 237.28 counts/minute) and 7-day PAR (Median: 8 METs/hour/week). Physical activity was negatively correlated with plasma fibrinogen concentrations, which was evaluated by counts/min (r = -0.100; p<0.001) and METs/hour/week (r = -0.162; p<0.001). In a multiple linear regression analysis, fibrinogen concentrations of the subjects who performed more physical activity (third tertile of count/minute and METs/hour/week) respect to subjects who performed less (first tertile), maintained statistical significance after adjustments for age and others confounders (β = -0.03; p = 0.046 and β = -0.06; p<0.001, respectively).


CONCLUSIONS
Physical activity, as assessed by accelerometer and 7-day PAR, was negatively associated with plasma fibrinogen concentrations. This relation is maintained in subjects who performed more exercise even after adjusting for age and other confounders.
Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service-SACYL, IBSAL, and Department of Medicine, University of Salamanca, Salamanca, Spain.
Manuel A
MA
Gomez-Marcos
Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service-SACYL, Salamanca, Spain.
José I
JI
Recio-Rodríguez
Stadistics Department, University of Salamanca, and Primary Care Research Unit, The Alamedilla Health Center, Salamanca, Spain.
Maria C
MC
Patino-Alonso
Social and Health Care Research Center, University of Castilla-La Mancha, Cuenca, Spain.
Vicente
V
Martinez-Vizcaino
DEA, Ciències de l'Educació i l'Esport (FPCEE) Universitat Ramon Llull, Barcelona, Spain.
Carme
C
Martin-Borras
Casa of Barco Health Center, Castilla and León Health Service-SACYL,Valladolid, Spain.
Aventina
A
de-la-Cal-Dela-Fuente
Torre Ramona Health Center, Aragón Health Service - Salud, Zaragoza, Spain.
Ines
I
Sauras-Llera
Primary Care Research Unit of Bizkaia, Basque Health Service-Osakidetza, Bilbao, Spain.
Alvaro
A
Sanchez-Perez
Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service-SACYL, Salamanca, Spain.
Cristina
C
Agudo-Conde
Primary Care Research Unit, The Alamedilla Health Center, Castilla and León Health Service-SACYL, IBSAL, and Department of Medicine, University of Salamanca, Salamanca, Spain.
Luis
L
García-Ortiz
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D015444:Exercise / Q000502:physiology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005500:Follow-Up Studies; D064368:Healthy Volunteers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult
D015415:Biomarkers; D005340:Fibrinogen