Six1: a critical transcription factor in tumorigenesis.
In the past two decades, many studies have shown that sine oculis homeobox 1 (Six1) is a powerful regulator of organogenesis and disease, with important roles in tumorigenesis; therefore, it is important to review the biology of Six1 gene comprehensively. This review describes the function of Six1 in normal organ development, summarizes its role in several diseases, including cancer. The review will extend our understanding about the functional roles of Six1 and suggests opportunities to target Six1 for diagnostic, prognostic, and therapeutic purposes.
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China; Huaian Academy of Nanjing Agricultural University, Huaian, Jiangsu, China.
Wangjun
W
Wu
Zhuqing
Z
Ren
Pinghua
P
Li
Debing
D
Yu
Jie
J
Chen
Ruihua
R
Huang
Honglin
H
Liu
D000818:Animals; D019280:Branchio-Oto-Renal Syndrome / Q000209:etiology; D063646:Carcinogenesis; D018398:Homeodomain Proteins / Q000502:physiology*; D006801:Humans; D038081:Organogenesis; D014157:Transcription Factors / Q000502:physiology*
D018398:Homeodomain Proteins; C099236:SIX1 protein, human; D014157:Transcription Factors
Six1; cancer; disease; organs development