Effect of different hemodialyzers on serum levels of interleukin-6, interleukin-10 and interleukin-18.
BACKGROUND
The blood and membrane contact during dialysis may elicit an immune reaction. The current study looked at the impact of different dialyzers on blood levels of cytokines.


METHODS
During the first month, randomly selected patients were treated with one dialyzer (PF-170H) and then crossed over to another dialyzer (FLX-18GW) during the next month. Pre- and postdialysis blood samples were assayed for interleukin (IL)-6, IL-10 and IL-18.


RESULTS
A significant drop of postdialysis systolic blood pressure (pre vs. post 156.4 ± 31.8 vs. 143.1 ± 24.8 mm Hg, p = 0.014) and diastolic pressure (80.7 ± 12.7 vs. 73.4 ± 10.9 mm Hg, p = 0.002) were found when patients were dialyzed with PF-170H. A significant increase of postdialysis IL-18 levels was found in both groups (pre vs. post 605.5 ± 278.6 vs. 690.6 ± 315.3 pg/ml, p = 0.016, for PF-170H and 556.4 ± 231.0 vs. 647.3 ± 282.6 pg/ml, p = 0.067, for FLX-18GW). There was a positive correlation between IL-6 and IL-10 levels (p < 0.0001).


CONCLUSIONS
We demonstrated a significant increase of postdialysis serum IL-18 level when either dialyzer was used. There is a strong correlation between serum levels of IL-6 and IL-10.
Division of Nephrology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
Kuo-Hsiung
KH
Shu
Chi-Hung
CH
Cheng
Ming-Ju
MJ
Wu
Cheng-Hsu
CH
Chen
Tung-Min
TM
Yu
Ya-Wen
YW
Chuang
Shih-Ting
ST
Huang
Shang-Feng
SF
Tsai
Ying-Chih
YC
Lo
D000368:Aged; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D020382:Interleukin-18 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D007688:Kidneys, Artificial; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D016896:Treatment Outcome; D014511:Uremia / Q000097:blood / Q000209:etiology / Q000628:therapy
D020382:Interleukin-18; D015850:Interleukin-6; D016753:Interleukin-10