Iridium-catalyzed intermolecular azide-alkyne cycloaddition of internal thioalkynes under mild conditions.
An iridium-catalyzed azide-alkyne cycloaddition reaction (IrAAC) of electron-rich internal alkynes is described. It is the first efficient intermolecular AAC of internal thioalkynes. The reaction exhibits remarkable features, such as high efficiency and regioselectivity, mild reaction conditions, easy operation, and excellent compatibility with air and a broad spectrum of organic and aqueous solvents. It complements the well-known CuAAC and RuAAC click reactions.
Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR (China).
Shengtao
S
Ding
Guochen
G
Jia
Jianwei
J
Sun
click chemistry; cycloaddition; heterocycles; iridium; triazoles