Controlled release from magnetoliposomes aqueous suspensions exposed to a low intensity magnetic field.
Recently, the use of liposomes loaded with magnetic nanoparticles (magnetoliposomes, (MLs)) has been intensely growing as a new drug delivery system. With the use of alternating magnetic fields, it is possible to remotely control the delivery of a drug or any other macromolecule loaded inside the MLs. In this experiment, the release of a fluorescent dye from MLs is achieved through an alternating magnetic field of 20 kHz and amplitude below 100 A/m, and without a macroscopic temperature increase.
Department of Chemistry and Drug Technology, Sapienza University of Rome, Rome, Italy.
Romina
R
Spera
Stefania
S
Petralito
Micaela
M
Liberti
Caterina
C
Merla
Guglielmo
G
d'Inzeo
Rosanna
R
Pinto
Francesca
F
Apollonio
D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D008081:Liposomes; D060526:Magnetic Fields; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D010865:Pilot Projects; D013696:Temperature
D003692:Delayed-Action Preparations; D008081:Liposomes
IF magnetic field; drug delivery; liposomes; magnetic nanoparticle; stimuli-responsive carriers