Indium chloride catalyzed alkylative rearrangement of propargylic acetates using alkyl chlorides, alcohols, and acetates: facile synthesis of α-alkyl-α,β-unsaturated carbonyl compounds.
Indium chloride catalyzed alkylative rearrangement of propargylic acetates into α-alkyl-α,β-unsaturated carbonyl compounds has been achieved. Propargylic acetates functioned as α-acylvinyl anion equivalents to react with carbocations generated from alkyl chlorides. Other alkyl electrophiles such as alcohols and acetates were also applicable.
Department of Applied Chemistry, Graduate School of Engineering, Osaka University 2-1 , Yamada-oka, Suita, Japan.
Yoshiharu
Y
Onishi
Yoshihiro
Y
Nishimoto
Makoto
M
Yasuda
Akio
A
Baba