A RIDDle solved: why an intact IRE1α/XBP-1 signaling relay is key for humoral immune responses.
As they commit to plasma cell differentiation, B lymphocytes must swiftly gear up to produce and secrete huge amounts of antibodies. To develop their secretory capacity, B cells exploit a signaling pathway that is employed by all eukaryotic cells in response to endoplasmic reticulum stress. An article by Benhamron et al. in this issue of the European Journal of Immunology, [Eur. J. Immunol. 2014. 44: 867-876] sheds new light on why an intact IRE1/XBP-1 signaling relay is central to orchestrate the full-blown expansion of the secretory machinery needed for massive antibody production.
San Raffaele Scientific Institute & Università Vita-Salute San Raffaele, Milan, Italy.
Eelco
E
van Anken
Andrea
A
Orsi
Roberto
R
Sitia
D000818:Animals; D000917:Antibody Formation / Q000502:physiology*; D007136:Immunoglobulins / Q000096:biosynthesis*; D008565:Membrane Proteins / Q000378:metabolism*; D010950:Plasma Cells / Q000276:immunology* / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
D007136:Immunoglobulins; D008565:Membrane Proteins; C486556:Ern2 protein, mouse; D017346:Protein Serine-Threonine Kinases
Antibody production; IRE1; Plasma cells; Regulated IRE1-dependent decay (RIDD); Unfolded protein response; XBP-1