Hemodiafiltration does not have additional benefits over hemodialysis on arterial stiffness, wave reflections and central aortic pressures.
OBJECTIVE
The hypothesis that dialytic modality affects arterial stiffness was never investigated. This study includes comparative evaluation of hemodiafiltration versus hemodialysis on arterial function during first and second weekly dialysis sessions.


METHODS
24 patients receiving hemodiafiltration and another 24 age- and sex-matched controls receiving hemodialysis were included. Patients were evaluated before and after first and second weekly dialysis sessions. Applanation tonometry of peripheral arteries was applied to determine aortic and brachial pulse wave velocity and heart rate-adjusted augmentation index (AIx(75)).


RESULTS
Hemodiafiltration and hemodialysis reduced AIx(75), but not aortic and brachial pulse wave velocity. Intradialytic reductions in AIx(75) did not differ between hemodiafiltration and hemodialysis in first and mid-week dialysis. In multivariate linear regression, predictors of intradialytic reduction in AIx(75) were changes in body weight and central aortic systolic blood pressure, but not dialytic modality.


CONCLUSIONS
This study showed that hemodiafiltration has similar effects with hemodialysis on wave reflections and stiffness.
Section of Nephrology and Hypertension, 1st Department of Medicine, AHEPA University Hospital, Thessaloniki, Greece.
Panagiotis I
PI
Georgianos
Pantelis A
PA
Sarafidis
Antonios
A
Karpetas
Dimitrios
D
Kosmidis
Athanasios
A
Sioulis
Vassilios
V
Liakopoulos
Dimitrios N
DN
Stamatiadis
Aikaterini
A
Papagianni
Pantelis E
PE
Zebekakis
Pavlos
P
Nikolaidis
Anastasios N
AN
Lasaridis
D001011:Aorta / Q000502:physiology; D062186:Arterial Pressure; D001158:Arteries / Q000502:physiology*; D001783:Blood Flow Velocity; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D008297:Male; D011673:Pulsatile Flow; D006435:Renal Dialysis; D014655:Vascular Resistance; D059289:Vascular Stiffness