Simultaneous presentation of kappa-restricted chronic lymphocytic leukemia and lambda light chain AL amyloidosis.
We report on a 58-year-old man who presented with simultaneous kappa-restricted chronic lymphocytic leukemia (CLL) and a lambda-restricted plasma cell dyscrasia causing AL amyloidosis involving the kidney and GI tract. While monoclonal immunoglobulins occasionally produced by CLL has previously been implicated in AL amyloidosis, this is the first case of AL amyloidosis resulting from a distinct plasma cell dyscrasia that is not clonally related to the concurrent CLL. Appropriate treatment depended on detailed pathologic diagnosis of both disease processes.
Department of Hematology and Oncology, University of Chicago, Chicago, IL, USA .
Gottfried
G
von Keudell
Vaishali
V
Sanchorawala
Carl
C
O'Hara
David
D
C Seldin
J Mark
JM
Sloan
D000686:Amyloidosis / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D000075363:Immunoglobulin Light-chain Amyloidosis; D007146:Immunoglobulin lambda-Chains / Q000378:metabolism; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains
AL amyloidosis; CLL; plasma cell dyscrasia