[Intermediate term outcome in 70 patients with Tako-Tsubo syndromes].
BACKGROUND
Tako-Tsubo syndrome is a reversible left ventricular myocardial dysfunction. There are few publications on its evolution and the purpose of this study is to describe the medium-term outcome of patients who presented this pathology.


METHODS
This retrospective study included 70 patients presenting with Tako-Tsubo syndrome who were referred to Haut-Lévèque hospital between November 2003 and January 2012. The parameters included in follow-up were: number of cardiovascular events, recurrence, electrocardiographic and echocardiographic evolution.


RESULTS
Sixty-eight patients had a mean follow-up of 4.8±2.4 years. The survival rate was 92%, 39 patients (57%) showed no cardiovascular symptoms, 12 (18%) had one or more new episodes of chest pain and 4 (6%) had stage II dyspnoea on the NYHA classification scale. One patient had a recurrence 6.5 years later, triggered by the same stress as the first instance. Forty-five patients (64%) had ECGs which evolved in the early days to diffuse T-wave inversion. In the medium term, 32 (54%) patients had a normal ECG, 19 (32%) had inverted T-waves in precordial leads and 2 (3%) had Q-waves. In terms of echocardiography, left ventricular ejection fraction was normal in all with variable delays. Four patients continued to have apical hypokinesia.


CONCLUSIONS
This study shows that the medium-term outlook is favourable in terms of cardiovascular mortality and that recurrence is rare. It highlights, however, the persistence of electrocardiographic and echocardiographic abnormalities.
Service de cardiologie, hôpital d'instruction des armées Robert-Picqué, 351, route de Toulouse, 33882 Villenave-d'Ornon cedex, France.
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Réglat
Service de cardiologie, hôpital d'instruction des armées Robert-Picqué, 351, route de Toulouse, 33882 Villenave-d'Ornon cedex, France.
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Chevalier
Service de cardiologie et maladies vasculaires, hôpital cardiologique du Haut-Lévêque, soins intensifs, plateau de cardiologie interventionnelle, CHU de Bordeaux, avenue de Magellan, 33604 Pessac cedex, France.
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Coste
Service de cardiologie, hôpital d'instruction des armées Robert-Picqué, 351, route de Toulouse, 33882 Villenave-d'Ornon cedex, France.
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Godon
Service de cardiologie, hôpital d'instruction des armées Robert-Picqué, 351, route de Toulouse, 33882 Villenave-d'Ornon cedex, France.
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Renault
Service de cardiologie et d'échocardiographie, hôpital cardiologique du Haut-Lévêque, CHU de Bordeaux, avenue de Magellan, 33604 Pessac cedex, France.
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Roudaut
Service de cardiologie et maladies vasculaires, hôpital cardiologique du Haut-Lévêque, soins intensifs, plateau de cardiologie interventionnelle, CHU de Bordeaux, avenue de Magellan, 33604 Pessac cedex, France.
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Seguy
Service de cardiologie et maladies vasculaires, hôpital cardiologique du Haut-Lévêque, soins intensifs, plateau de cardiologie interventionnelle, CHU de Bordeaux, avenue de Magellan, 33604 Pessac cedex, France. Electronic address: edouard.gerbaud@chu-bordeaux.fr.
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Gerbaud
D000368:Aged; D002637:Chest Pain / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D054549:Takotsubo Cardiomyopathy / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000401:mortality; D014463:Ultrasonography
Devenir; Echocardiography; Electrocardiogram; Epidemiology; Outcome; Stress; Syndrome de Tako-Tsubo; Tako-Tsubo syndrome; Échocardiographie; Électrocardiogramme; Épidémiologie