Induced murine models of systemic lupus erythematosus.
Induced mouse models of systemic lupus erythematosus (SLE) have been developed to complement the spontaneous models. This chapter describes the methods used in the pristane-induced model and the chronic graft-versus-host disease (cGVHD) model, both of which have been extensively used. We will also outline the specific mechanisms of systemic autoimmunity that can be best characterized using each of these models.
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Florida, Gainesville, FL, USA.
Yuan
Y
Xu
Leilani
L
Zeumer
Westley H
WH
Reeves
Laurence
L
Morel
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D004195:Disease Models, Animal; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D008181:Lupus Nephritis; D008297:Male; D051379:Mice; D010641:Phenotype; D013729:Terpenes / Q000009:adverse effects
D016207:Cytokines; D007136:Immunoglobulins; D013729:Terpenes; C009042:pristane