Silver-catalyzed cross-coupling of propargylic alcohols with isocyanides: an atom-economical synthesis of 2,3-allenamides.
Cross-coupling reactions between propargylic alcohols and isocyanides, by means of silver catalysis, have been described. This new reaction is both atom and step efficient and is applicable to a broad scope of substrates, allowing the synthesis of a range of synthetically valuable 2,3-allenamides in moderate to excellent yields.
Department of Chemistry, Northeast Normal University, Changchun 130024 (China).
Jianquan
J
Liu
Zhenhua
Z
Liu
Nannan
N
Wu
Peiqiu
P
Liao
Xihe
X
Bi
2,3-allenamides; cross-coupling; isocyanides; propargylic alcohols; silver catalysis