Quinolone alkaloids from Fructus Euodiae show activity against methicillin-resistant Staphylococcus aureus.
Fructus Euodiae is used in traditional Chinese medicine to treat infection. In this study, four of the quinolone alkaloids isolated from Fructus Euodiae showed activity against methicillin-resistant Staphylococcus aureus (MRSA). The minimum inhibitory concentrations (MIC) were 8-128 µg/mL, which were equivalent to or lower than the control antibiotics, oxacillin, erythromycin and tetracycline (MIC ≥128 µg/mL). Among these isolated quinolone alkaloids, evocarpine with a 13 carbon alkenyl chain substituent at position-2 showed the best activity against MRSA. This study has demonstrated the potential of quinolone alkaloids from Fructus Euodiae as anti-MRSA compounds and supports the traditional use of the fruit as a treatment for bacterial infections.
School of Human Sciences, Faculty of Life Sciences and Computing, London Metropolitan University, 166-220 Holloway Road, London, N7 8DB, UK.
Xiaobei
X
Pan
S W Annie
SW
Bligh
Eileen
E
Smith
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D032086:Evodia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000302:isolation & purification / Q000494:pharmacology*; D015363:Quinolones
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal; D011804:Quinolines; D015363:Quinolones; C059242:evocarpine
Evocarpine; MIC; MRSA; antibacterial; minimum inhibitory concentration