[Role of Nods like receptors in the patients with nasal polyps].
OBJECTIVE
To investigate the expression and role of a new pattern-recognition receptors (PRR), nucleotide binding oligomerization domain (Nod) like receptors (NLRs), in the patients with nasal polyps and nasal septum normal control group.


METHODS
The expressions of Nod1, Nod2 and Nalp3 mRNA and protein were explored with real-time RT-PCR, Western-Blot and immunohistochemistry respectively.


RESULTS
The protein levels of Nod1, Nod2 and Nalp3 were expressed in nasal polyp and the control, but the expression of Nod1 and Nalp3 in nasal polyps were higher than those in control. No significant difference of Nod2 was seen between the two groups. And then, there was no significant difference of Nod1, Nod2, Nalp3 mRNA between two groups with Real-time RT-PCR.


CONCLUSIONS
The expression of Nod1 and Nalp3 are increased in nasal polyp tissues and maybe a etiological factors in the formation of nasal polyps.
Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China.
Shenhua
S
Zhang
Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China.
Congxiang
C
Shen
Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China.
Zhong
Z
Wen
Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China.
Guanxue
G
Li
Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China.
Keke
K
Yang
Department of Otorhinolaryngology-Head and Neck Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China.
Xin
X
Shi
D000328:Adult; D002352:Carrier Proteins / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology; D053474:Nod1 Signaling Adaptor Protein / Q000378:metabolism*; D053473:Nod2 Signaling Adaptor Protein / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000378:metabolism*
D002352:Carrier Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; C119067:NOD1 protein, human; C429018:NOD2 protein, human; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D051192:Receptors, Pattern Recognition