Enteropathic arthritis in Brazil: data from the Brazilian Registry of Spondyloarthritis.
Inflammatory bowel diseases (Crohn's disease and ulcerative rectocolitis) have extraintestinal manifestations 25% of the patients, with the most common one being the enteropathic arthritis.


METHODS
Prospective, observational, multicenter study with patients from 29 reference centers participating in the Brazilian Registry of Spondyloarthritis (RBE), which incorporates the RESPONDIA (Ibero-American Registry of Spondyloarthritis) group. Demographic and clinical data were collected from 1472 patients and standardized questionnaires for the assessment of axial mobility, quality of life, enthesitic involvement, disease activity and functional capacity were applied. Laboratory and radiographic examinations were performed. The aim of this study is to compare the clinical, epidemiological, genetic, imaging, treatment and prognosis characteristics of patients with enteropathic arthritis with other types of spondyloarthritis in a large Brazilian cohort.


RESULTS
A total of 3.2% of patients were classified as having enteroarthritis, 2.5% had spondylitis and 0.7%, arthritis (peripheral predominance). The subgroup of individuals with enteroarthritis had a higher prevalence in women (P < 0.001), lower incidence of inflammatory axial pain (P < 0.001) and enthesitis (P = 0.004). HLA-B27 was less frequent in the group with enteroarthritis (P = 0.001), even when considering only those with the pure axial form. There was a lower prevalence of radiographic sacroiliitis (P = 0.009) and lower radiographic score (BASRI) (P = 0.006) when compared to patients with other types of spondyloarthritis. They also used more corticosteroids (P < 0.001) and sulfasalazine (P < 0.001) and less non-steroidal anti-inflammatory drugs (P < 0.001) and methotrexate (P = 0.001).


CONCLUSIONS
There were differences between patients with enteroarthritis and other types of spondyloarthritis, especially higher prevalence of females, lower frequency of HLA-B27, associated with less severe axial involvement.
Gustavo G
GG
Resende
Cristina C D
CC
Lanna
Adriana B
AB
Bortoluzzo
Célio R
CR
Gonçalves
José Antonio Braga
JA
da Silva
Antonio Carlos
AC
Ximenes
Manoel B
MB
Bértolo
Sandra L E
SL
Ribeiro
Mauro
M
Keiserman
Rita
R
Menin
Thelma L
TL
Skare
Sueli
S
Carneiro
Valderílio F
VF
Azevedo
Walber P
WP
Vieira
Elisa N
EN
Albuquerque
Washington A
WA
Bianchi
Rubens
R
Bonfiglioli
Cristiano
C
Campanholo
Hellen M S
HM
Carvalho
Izaias P
IP
Costa
Angela P
AP
Duarte
Charles L
CL
Kohem
Nocy
N
Leite
Sonia A L
SA
Lima
Eduardo S
ES
Meirelles
Ivânio A
IA
Pereira
Marcelo M
MM
Pinheiro
Elizandra
E
Polito
Francisco Airton C
FA
Rocha
Mittermayer B
MB
Santiago
Maria de Fátima L C
Mde F
Sauma
Valeria
V
Valim
Percival D
PD
Sampaio-Barros
D000328:Adult; D001168:Arthritis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D001938:Brazil; D003093:Colitis, Ulcerative / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012042:Registries; D025241:Spondylarthritis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy