Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model.
Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease.
Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Sung Hoon
SH
Baik
Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Moon-Yong
MY
Cha
Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
Young-Min
YM
Hyun
BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hansang
H
Cho
BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Bashar
B
Hamza
Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Dong Kyu
DK
Kim
Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Sun-Ho
SH
Han
Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Heesun
H
Choi
Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Kyung Ho
KH
Kim
Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.
Minho
M
Moon
Department of Pharmacology, College of Pharmacy, Seoul National University, Seoul, Korea.
Jeewoo
J
Lee
Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea; Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
Minsoo
M
Kim
BioMEMS Resource Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Daniel
D
Irimia
Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea. Electronic address: inhee@snu.ac.kr.
Inhee
I
Mook-Jung
D000544:Alzheimer Disease / Q000276:immunology*; D000818:Animals; D001921:Brain / Q000276:immunology*; D002465:Cell Movement / Q000276:immunology*; D002478:Cells, Cultured; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008853:Microscopy / Q000379:methods; D057054:Molecular Imaging / Q000379:methods; D009504:Neutrophils / Q000276:immunology*; D058225:Plaque, Amyloid / Q000276:immunology*
Alzheimer's disease; Amyloid plaques; Immune cells; Neutrophils