Science to practice: Can we turn the undesired heating effects of MR imaging into effective cancer therapies?
In this basic research study, Zhang et al created and report on a clever magnetic resonance (MR)-guided radiofrequency (RF) system that enables focal hyperthermic heating, targeting, and visualization for the treatment of cholangiocarcinoma. The key novelty is creating localized MR-induced heating around a metallic guidewire, which they subsequently demonstrate can be successfully combined with chemotherapy to (a) reduce cell proliferation in vitro, (b) decrease tumor growth in mouse xenografts, and (c) increase biliary uptake of chemotherapeutic drugs in swine. An added benefit of the system is using the wire as an intraluminal receiver antenna to improve the resolution of intraprocedural imaging guidance.
Image-guided Therapy and Interventional Oncology Unit, Department of Radiology Hadassah Hebrew University Medical Center Ein Karem Jerusalem, Israel Minimally Invasive Tumor Therapy Laboratory Section of Interventional Radiology Department of Radiology Beth Israel Deaconess Medical Center/Harvard Medical School 330 Brookline Ave Boston, MA 02215.
S Nahum
SN
Goldberg
D000818:Animals; D001650:Bile Duct Neoplasms / Q000628:therapy*; D018281:Cholangiocarcinoma / Q000628:therapy*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D006979:Hyperthermia, Induced; D008279:Magnetic Resonance Imaging / Q000379:methods*; D000093542:Gemcitabine
D003841:Deoxycytidine; D005472:Fluorouracil; D000093542:Gemcitabine