A short expedient synthesis of [(14)C]Ticlopidine.
To support the development of a reactive metabolite strategy, the preparation of several radiolabelled compounds such as [(14)C] Ticlopidine was required. In this report, we describe a facile and rapid synthesis of [(14)C] Ticlopidine starting from [(14)C] carbon dioxide. The compound was radiolabelled in the 2-chloromethyl portion of the molecule with a specific activity of 53.4 mCi/mmol and with a radiochemical purity of 98.5%. Storage stability was best as the hydrochloride salt in an ethanol solution.
Isotope Chemistry, AstraZeneca R&D, Alderley Park, Alderley Edge, SK10 4TG, UK.
Michael J
MJ
Hickey
Lee P
LP
Kingston
Paul H
PH
Allen
Tim
T
Johnson
David J
DJ
Wilkinson
D002250:Carbon Radioisotopes; D060326:Chemistry Techniques, Synthetic; D007700:Kinetics; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D013988:Ticlopidine / Q000138:chemical synthesis* / Q000737:chemistry
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013988:Ticlopidine
carbon-14; metal-halogen exchange; ticlopidine