The microbiome and psoriatic arthritis.
Psoriatic arthritis is a chronic inflammatory joint disease, seen in combination with the chronic inflammatory skin disease psoriasis and belonging to the family of spondylarthritides (SpA). A link is recognized between psoriatic arthritis and inflammatory bowel disease (IBD). Environmental factors seem to induce inflammatory disease in individuals with underlying genetic susceptibility. The microbiome is a subject of increasing interest in the etiology of these inflammatory immune-mediated diseases. The intestinal microbiome is able to affect extra-intestinal distant sites, including the joints, through immunomodulation. At this point, evidence regarding a relationship between the microbiome and psoriatic arthritis is scarce. However, we hypothesize that common immune-mediated inflammatory pathways seen in the "skin-joint-gut axis" in psoriatic arthritis are induced or at least mediated by the microbiome. Th17 has a crucial function in this mechanism. Further establishment of this connection may lead to novel therapeutic approaches for psoriatic arthritis.
Department of Dermatology, Erasmus MC-University Medical Center Rotterdam, s Gravendijkwal 230, NL-3000, CA, Rotterdam, The Netherlands, hestereppinga@gmail.com.
Hester
H
Eppinga
Sergey R
SR
Konstantinov
Maikel P
MP
Peppelenbosch
H Bing
HB
Thio
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015535:Arthritis, Psoriatic / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D015551:Autoimmunity; D005243:Feces / Q000382:microbiology; D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D007422:Intestines / Q000382:microbiology; D064307:Microbiota / Q000276:immunology; D019936:Probiotics / Q000627:therapeutic use; D012867:Skin / Q000382:microbiology; D013559:Symbiosis; D016176:T-Lymphocyte Subsets / Q000276:immunology; D016378:Tissue Transplantation / Q000379:methods
D000900:Anti-Bacterial Agents