Effect of immunotherapy on the response of TICLs to solid tumour invasion.
There is clinical evidence that some people have lived with a benign tumour for their entire life time. This is explained by cancer dormancy which is attributed to the interaction of tumour infiltrating cytotoxic lymphocytes (TICLs) with tumour cells. We present two mathematical models to study the mechanism of interaction of TICLs with tumour cells, with and without clinical intervention. Stability analysis and numerical simulations of the models reveal the existence of a stable tumour dormant state.
University of Kwazulu Natal, School of Mathematics, Statistics, and Computer Science, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa. Electronic address: Mambilimamboundou@ukzn.ac.za.
Hermane
H
Mambili-Mamboundou
University of Kwazulu Natal, School of Mathematics, Statistics, and Computer Science, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa. Electronic address: SibandaP@ukzn.ac.za.
Precious
P
Sibanda
University of Kwazulu Natal, School of Mathematics, Statistics, and Computer Science, Private Bag X01, Scottsville, Pietermaritzburg 3209, South Africa. Electronic address: josephmalinzi@aims.ac.za.
Joseph
J
Malinzi
D003198:Computer Simulation; D006801:Humans; D007167:Immunotherapy; D007376:Interleukin-2 / Q000378:metabolism; D016246:Lymphocytes, Tumor-Infiltrating / Q000145:classification / Q000276:immunology* / Q000473:pathology; D055641:Mathematical Concepts; D018448:Models, Immunological; D009361:Neoplasm Invasiveness / Q000276:immunology* / Q000473:pathology; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology / Q000628:therapy
C508594:IL2 protein, human; D007376:Interleukin-2
Cancer dormancy; Immunotherapy; Resting cells; Tumour-immune interactioné TICLs-tumour interactions