Modeling of femoral neck cortical bone for the numerical simulation of ultrasound propagation.
Quantitative ultrasound assessment of the cortical compartment of the femur neck (FN) is investigated with the goal of achieving enhanced fracture risk prediction. Measurements at the FN are influenced by bone size, shape and material properties. The work described here was aimed at determining which FN material properties have a significant impact on ultrasound propagation around 0.5 MHz and assessing the relevancy of different models. A methodology for the modeling of ultrasound propagation in the FN, with a focus on the modeling of bone elastic properties based on scanning acoustic microscopy data, is introduced. It is found that the first-arriving ultrasound signal measured in through-transmission at the FN is not influenced by trabecular bone properties or by the heterogeneities of the cortical bone mineralized matrix. In contrast, the signal is sensitive to variations in cortical porosity, which can, to a certain extent, be accounted for by effective properties calculated with the Mori-Tanaka method.
Sorbonne Universités, UPMC Univ Paris 06, UMR 7623, LIP, F-75006, Paris, France; CNRS, UMR 7623, LIP, F-75006, Paris, France. Electronic address: quentin.grimal@upmc.fr.
Quentin
Q
Grimal
Julius Wolff Institute and Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Daniel
D
Rohrbach
Sorbonne Universités, UPMC Univ Paris 06, UMR 7623, LIP, F-75006, Paris, France; CNRS, UMR 7623, LIP, F-75006, Paris, France.
Julien
J
Grondin
Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Universitätklinikum Schleswig-Holstein, Campus Kiel, Germany.
Reinhard
R
Barkmann
Sektion Biomedizinische Bildgebung, Klinik für Radiologie und Neuroradiologie, Universitätklinikum Schleswig-Holstein, Campus Kiel, Germany.
Claus-C
CC
Glüer
Julius Wolff Institute and Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Kay
K
Raum
Sorbonne Universités, UPMC Univ Paris 06, UMR 7623, LIP, F-75006, Paris, France; CNRS, UMR 7623, LIP, F-75006, Paris, France.
Pascal
P
Laugier
D015519:Bone Density / Q000502:physiology; D003198:Computer Simulation / Q000706:statistics & numerical data*; D004548:Elasticity / Q000502:physiology; D005265:Femoral Neck Fractures / Q000000981:diagnostic imaging; D005272:Femur Neck / Q000000981:diagnostic imaging*; D006801:Humans; D033401:Microscopy, Acoustic / Q000379:methods*; D008875:Middle Aged; D008954:Models, Biological; D011237:Predictive Value of Tests; D012307:Risk Factors
Acoustic microscopy; Cortical bone; Elasticity; Femur; Fracture risk; Homogenization; Porosity; Quantitative ultrasound