Nonalcoholic fatty liver disease and bariatric surgery in adolescents.
Obesity is a multi-organ system disease with underlying insulin resistance and systemic chronic inflammation. Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of the underlying metabolic dysfunction. This review provides a highlight of the current understanding of NAFLD pathogenesis and disease characteristics, with updates on the challenges of NAFLD management in obese and severely obese (SO) patients and recommendations for the pediatric surgeons' role in the care of SO adolescents.
Department of Surgery, University of Illinois College of Medicine, Peoria, Illinois; Pediatric Surgery, Children's Hospital of Illinois, University of Illinois College of Medicine, Peoria, Illinois. Electronic address: aixuan.l.holterman@osfhealthcare.org.
AiXuan
A
Holterman
Department of Surgery, University of Illinois College of Medicine, Peoria, Illinois.
Juan
J
Gurria
Department of Surgery, University of Illinois College of Medicine, Peoria, Illinois; Pediatric Surgery, Children's Hospital of Illinois, University of Illinois College of Medicine, Peoria, Illinois.
Smita
S
Tanpure
Department of Surgery, University of Illinois College of Medicine, Peoria, Illinois; Pediatric Surgery, Children's Hospital of Illinois, University of Illinois College of Medicine, Peoria, Illinois.
Nerina
N
DiSomma
D000293:Adolescent; D050110:Bariatric Surgery; D003131:Combined Modality Therapy; D005234:Fatty Liver / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D065626:Non-alcoholic Fatty Liver Disease; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D063766:Pediatric Obesity / Q000150:complications / Q000601:surgery*; D012307:Risk Factors; D016896:Treatment Outcome
Adolescent morbid obesity; Metabolic dysfunction; Nonalcoholic fatty liver disease