[Real-world study of effect on liver function of parenterally administered shuxuetong with different doses].
OBJECTIVE
To analyze the effect on liver function of parenterally administered Shuxuetong Injection with different doses.


METHODS
The study is based on hospital information system (HIS) data. We group the cases by dose: The observation group receive a dose > 6 mL (recommended daily dose), the matched group receive the recommended dose. Chi-square test, logistic regression, logistic regression with propensity score, logistic regression with GBM propensity score were used to find the between group differences in ALT and AST after using parentyerally administered Shuxuetong injection.


RESULTS
All tests show that there were no significant differences between groups in AST or ALT after we control for confounding factors.


CONCLUSIONS
Based on HIS data, there was no evidence to associate the use of Shuxuetong over the recommended dose and effects on liver function.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. wzhftcm@163.com
Zhi-Fei
ZF
Wang
Renmin University of China, Beijing 100872, China.
Jian
J
Huo
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Jun-Jie
JJ
Jiang
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yan-Ming
YM
Xie
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D016022:Case-Control Studies; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006751:Hospital Information Systems / Q000706:statistics & numerical data; D006801:Humans; D007263:Infusions, Parenteral; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D064792:Pragmatic Clinical Trials as Topic; D057216:Propensity Score; D012189:Retrospective Studies; D055815:Young Adult
D004365:Drugs, Chinese Herbal; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase