Single-nucleotide polymorphisms at the 9p21.3 genomic region not associated with the risk of cardiovascular disease in patients with rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic polygenic inflammatory disease associated with accelerated atherosclerosis and high risk of cardiovascular disease (CVD). In this study, we evaluated the potential association of 9p21.3 single-nucleotide polymorphisms (SNPs) - previously linked to coronary artery disease - and CVD risk in 2001 Spanish RA patients genotyped for 9p21.3 SNPs using TaqMan™ assays. Carotid intima media thickness (cIMT) and presence of carotid plaques were also analyzed. Cox regression model did not disclose significant differences between patients who experienced CVD and those who did not. Neither association was found between cIMT or carotid plaques and SNPs allele distribution. In conclusion, results do not support a role of rs10116277 or rs1537375 SNPs in CVD risk in Spanish RA patients.
Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, 18016, Granada, Spain.
M
M
García-Bermúdez
R
R
López-Mejías
F
F
Genre
S
S
Castañeda
C
C
González-Juanatey
J
J
Llorca
A
A
Corrales
J A
JA
Miranda-Filloy
T
T
Pina
C
C
Gómez-Vaquero
L
L
Rodríguez-Rodríguez
B
B
Fernández-Gutiérrez
D
D
Pascual-Salcedo
A
A
Balsa
F J
FJ
López-Longo
P
P
Carreira
R
R
Blanco
I
I
González-Álvaro
J
J
Martín
M A
MA
González-Gay
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D002339:Carotid Arteries / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013030:Spain
9p21 single‐nucleotide polymorphisms; atherosclerosis; cardiovascular disease; rheumatoid arthritis