Treatment of renal manifestations of ANCA-associated vasculitis.
BACKGROUND
Vasculitis is a clinicopathological entity characterized by inflammation and necrosis of blood vessels.


METHODS
Directory of Open Access Journals (DOAJ), Google Scholar, Pubmed (NLM), LISTA (EBSCO) and Web of Science have been searched.


RESULTS
Two major autoantigens for ANCA are myeloperoxidase (MPO) and proteinase 3 (PR3), which are proteins in the primary granules of neutrophils and in the lysosomes of monocytes. They are expressed in mature neutrophils of patients with ANCA, while absent in healthy subjects.


CONCLUSIONS
The kidney is the most commonly affected vital organ in ANCA-associated vasculitis, and patient outcomes are largely determined by the severity of renal disease at diagnosis and by its response to treatment.
Department of Nephrology, Dubrava University Hospital, Zagreb Medical School, Zagreb, Croatia.
Kresimir
K
Galesic
Department of Pathology, Dubrava University Hospital, Zagreb Medical School, Zagreb, Croatia.
Danica
D
Ljubanovic
Department of Nephrology, Dubrava University Hospital, Zagreb Medical School, Zagreb, Croatia.
Ivica
I
Horvatic
ANCA-associated small-vessel vasculitis; Antineutrophil cytoplasmatic autoantibody; Chapel Hill Consensus Conference classification; Crescentic glomerulonephritis; Vasculitis