Novel vitamin D compounds and skin cancer prevention.
As skin cancer is one of the most costly health issues in many countries, particularly in Australia, the possibility that vitamin D compounds might contribute to prevention of this disease is becoming increasingly more attractive to researchers and health communities. In this article, important epidemiologic, mechanistic and experimental data supporting the chemopreventive potential of several vitamin D-related compounds are explored. Evidence of photoprotection by the active hormone, 1α,25dihydroxyvitamin D3, as well as a derivative of an over-irradiation product, lumisterol, a fluorinated analog and bufalin, a potential vitamin D-like compound, are provided. The aim of this article is to understand how vitamin D compounds contribute to UV adaptation and potentially, skin cancer prevention.
Department of Physiology Anatomy & Histology; Bosch Institute; The University of Sydney; Sydney, NSW Australia.
Wannit
W
Tongkao-On
Department of Physiology Anatomy & Histology; Bosch Institute; The University of Sydney; Sydney, NSW Australia.
Clare
C
Gordon-Thomson
Department of Physiology Anatomy & Histology; Bosch Institute; The University of Sydney; Sydney, NSW Australia.
Katie M
KM
Dixon
Department of Physiology Anatomy & Histology; Bosch Institute; The University of Sydney; Sydney, NSW Australia.
Eric J
EJ
Song
Department of Physiology Anatomy & Histology; Bosch Institute; The University of Sydney; Sydney, NSW Australia.
Tan
T
Luu
Department of Physiology Anatomy & Histology; Bosch Institute; The University of Sydney; Sydney, NSW Australia.
Sally E
SE
Carter
Department of Physiology Anatomy & Histology; Bosch Institute; The University of Sydney; Sydney, NSW Australia ; Oncology Research Unit; School of Medical Sciences; The University of New South Wales; Kensington, NSW Australia.
Vanessa B
VB
Sequeira
Department of Faculty of Veterinary Science; The University of Sydney; Sydney, NSW Australia.
Vivienne E
VE
Reeve
Department of Physiology Anatomy & Histology; Bosch Institute; The University of Sydney; Sydney, NSW Australia.
Rebecca S
RS
Mason
1α,25-dihydroxyvitaminD3; DNA damage; bufalin; photocarcinogenesis; photoimmune suppression; photoprotection; skin cancer prevention; vitamin D compounds; vitamin D photoproducts