No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak.
Chikungunya (CHIKV) and Dengue (DENV) viruses, both arboviruses, have caused multiple outbreaks worldwide. Their clinical features are poorly described in Africa and there is no comparative study, although Chikungunya is considered as a dengue-like disease. We conducted a comparative study of clinical and biological data from CHIKV and DENV positive patients during the 2010 Gabonese outbreak. Patients consulting with general symptoms and having laboratory confirmation for CHIKV or DENV were included. Clinical and biological data were recorded. Statistical analyses were performed using Epi Info. A P value < 0.05 was considered significant. In all, 270 CHIKV+, 53 DENV+ and 20 co-infected patients were included in the study. Headaches, hemorrhage, leukopenia and lymphopenia were significantly (P respectively 0.01, 0.001, 0.02 and 0.001) more frequent in DENV+ patients than in CHIKV+. There was no additive effect of the two viruses.These clinical and hematological disorders are non specific and cannot assist for the differential diagnosis. These diseases are clinically indistinguishable, and need for laboratory confirmation.
Unité des Maladies Virales Emergentes, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville; ; Ministère de la Santé Publique, Libreville;
Dieudonné
D
Nkoghe
Unité des Maladies Virales Emergentes, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville;
Roland Fabrice Kassa
RF
Kassa
Unité de Biologie Médicale et de Santé Publique, Centre International de Recherches Médicales de Franceville, Gabon;
Ulrich
U
Bisvigou
Unité des Maladies Virales Emergentes, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville;
Mélanie
M
Caron
Unité des Maladies Virales Emergentes, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville;
Gilda
G
Grard
Unité des Maladies Virales Emergentes, Centre International de Recherches Médicales de Franceville (CIRMF), Franceville; ; MIVEGEC, Montpellier, France.
Eric Maurice
EM
Leroy
Chikungunya- Dengue- Symptoms-Gabon.