Peripheral T cell lymphoma in Asia.
Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T- and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environmental factors, and infectious causes) have been proposed. PTCL are classified based on a combination of several parameters, including morphology, site of presentation, viral status, immunophenotype, and specific genetic alterations. Their classification is ongoing, with the emergence of new entities and refinement of existing entities because of the development of diagnostic markers and new genetic alterations. This review presents epidemiologic data for PTCL in Asia, together with recent progress in the pathology of PTCL compared with the WHO 2008 classification.
Department of Pathology and Global Top 5 Research Program, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
Sanghui
S
Park
Young Hyeh
YH
Ko
D000077548:Anaplastic Lymphoma Kinase; D001208:Asia / Q000453:epidemiology; D005770:Gastrointestinal Neoplasms; D004854:Herpesvirus 4, Human; D006801:Humans; D015994:Incidence; D007694:Killer Cells, Natural / Q000473:pathology / Q000821:virology; D016411:Lymphoma, T-Cell, Peripheral / Q000145:classification / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D008232:Lymphoproliferative Disorders / Q000473:pathology / Q000821:virology; D020794:Receptor Protein-Tyrosine Kinases; D012307:Risk Factors; D012878:Skin Neoplasms; D013601:T-Lymphocytes / Q000473:pathology / Q000821:virology; D014944:World Health Organization
D000077548:Anaplastic Lymphoma Kinase; D020794:Receptor Protein-Tyrosine Kinases