A cobalt-catalyzed alkene hydroboration with pinacolborane.
An extremely efficient cobalt catalyst for the hydroboration of both vinylarenes and aliphatic α-olefins with pinacolborane is described, providing the anti-Markovnikov products with excellent regio- and chemoselectivity, broad functional-group tolerance, and high turnover numbers (up to 19,800). The alkene hydroboration route is further extended to a two-step, one-pot hydroboration and cross-coupling of alkylboronates with aryl chlorides.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032 (China).
Lei
L
Zhang
Ziqing
Z
Zuo
Xuebing
X
Leng
Zheng
Z
Huang
alkenes; cobalt; cross-coupling; hydroboration; synthetic methods