Copper-catalyzed regio- and enantioselective hydroamination of alkenes with hydroxylamines.
Adding value: The catalytic hydroamination of alkenes with amines holds promise to rapidly deliver value-added chiral amines from simple and accessible starting materials. The use of mild, Cu-catalyzed electrophilic amination strategies for the regioselective preparation of both linear and chiral branched amines is highlighted.
Worldwide Medicinal Chemistry, Pfizer, Inc. Eastern Point Rd., Groton, CT 06340 (USA). kevin.hesp@pfizer.com.
Kevin D
KD
Hesp
D000475:Alkenes / Q000737:chemistry*; D000586:Amination; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006898:Hydroxylamines / Q000737:chemistry*; D008390:Markov Chains; D013237:Stereoisomerism
D000475:Alkenes; D006898:Hydroxylamines; D003300:Copper
amines; asymmetric; copper; hydroamination; umpolung