[The usefulness of evaluation of: ferritin, ultrasensitive CRP and tissue specific polypeptide 18th (TPS) in assessment of therapy efficacy in patients with nasal polyps].
BACKGROUND
Chronic rhinosinusitis with nasal polyps is social, clinical and cost-effective problem, by reason of bothersome symptoms, chronic nature of the disease, tendency to recur and lack of satisfying treatment.


OBJECTIVE
The aim of this study is assessment of suitability of hsCRP, ferritin and blood levels in nasal polyps patients in evaluation of treatment efficacy.


METHODS
The study enrolled 38 patients between 20 and 68 years of age. Patients were divided into 2 groups. Levels of ultrasensitive CRP ferritin and TPS have been measured in all patients. The ultrasensitive CRP levels have been measured by chemiluminescence method. Ferritin levels have been measured by MEIA method. The TPS levels have been measured by chemiluminescence method.


RESULTS
Comparison of mean ferritin levels in both study groups in each stage of observation shows the significant difference of mean values in only 6 weeks after surgery. Mean ferritin level is significantly lower in group I than in group II (p<0.05). Mean hsCRP levels vary from one corresponding to ferritin levels. Statistically significant difference between study groups in 2nd and 6th week after surgery has been ascertained (p<0.05). Similarly, like in ferritin levels, the TPS levels are significantly different in 6th week after surgery.


CONCLUSIONS
Analysis of ferritin, hsCRP and TPS serum levels indicates that these may be useful in assessment of treatment efficacy in patients with nasal polyps. Rise of the chosen inflammatory state parameter level in the postoperative monitoring and anti-inflammatory treatment introduction in nasal polyps patients may inhibit the recurrence of the disease.
Oddział Laryngologii Wojewódzkiego Szpitala Specjalistycznego nr 5 im Świętej Barbary w Sosnowcu, Polska.
Jacek
J
Pałac
Oddział Laryngologii Górnośląskiego Centrum Medycznego w Katowicach-Ochojcu, Polska.
Szczepan
S
Bratek
Katedra Anestezjologii, Intensywnej Terapii i Medycyny Ratunkowej Wydziału Lekarskiego z Oddziałem Lekarsko-Dentystycznym w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach, Polska. Electronic address: robertpartyka@op.pl.
Robert
R
Partyka
Katedra i Oddział Kliniczny Laryngologii w Zabrzu Śląskiego Uniwersytetu Medycznego w Katowicach, Polska.
Maciej
M
Misiołek
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D005293:Ferritins / Q000097:blood*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000097:blood* / Q000601:surgery*; D010455:Peptides / Q000097:blood*; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers; D018836:Inflammation Mediators; D010455:Peptides; D005293:Ferritins
Chronic rhinosinusitis; Ferritin; Nasal polyps; TPS; ferrytyna; hsCRP; polipy nosa; przewlekłe zapalenie zatok przynosowych