From ST segments to endothelial pathophysiology: hypercholesterolemia and endothelial superoxide production.
As a young medical resident, I encountered a patient suffering from spontaneous coronary vasospasm and was puzzled by these dramatic alterations in vasomotion. This encounter piqued my interest in understanding the drivers of vascular reactivity. In a paper published in the JCI, my colleagues and I revealed a role for superoxide production in the vascular dysfunction associated with hypercholesterolemia. Subsequent work by our group and others has unveiled complex associations between ROS generation and vascular disease.
David G
DG
Harrison
D000818:Animals; D035843:Biomedical Research / Q000266:history; D002986:Clinical Trials as Topic; D003329:Coronary Vasospasm / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D006937:Hypercholesterolemia / Q000503:physiopathology*; D007249:Inflammation; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D013481:Superoxides; D014652:Vascular Diseases / Q000503:physiopathology*
D017382:Reactive Oxygen Species; D013481:Superoxides