Lymphoplasmacytic lymphoma exposed by haemoptysis and acquired von Willebrand syndrome.
We report on a 36-year-old man who presented to the emergency department with haemoptysis. Computed tomography (CT) of the thorax showed a pulmonary mass paramediastinal in the right upper lobe, with the density of a haematoma. Laboratory data demonstrated an absolute lymphocytosis of 5.900 × 10/l (normal range, 1.150-3.250 × 10/l) and a prolonged activated partial thromboplastin time (APTT) of 47.7 s (normal range, 28.0-39.0 s). A de novo diagnosis of lymphoplasmacytic lymphoma (Waldenström macroglobulinaemia) was made, complicated by an acquired von Willebrand syndrome (aVWS) as demonstrated by further laboratory investigations. In this case report, we present a case of aVWS with markedly prolonged APTT and haemoptysis that revealed an underlying Waldenström macroglobulinaemia.
aCoagulation Laboratory, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent bClinical Laboratory cClinical Hematology dDepartment of Pathology, AZ Delta Hospital, Roeselare eDepartment of Pathology, Ghent University Hospital, Ghent, Belgium.
Line
L
Coucke
Ludo
L
Marcelis
Dries
D
Deeren
Jo
J
Van Dorpe
Kathleen
K
Lambein
Katrien
K
Devreese
D000328:Adult; D006469:Hemoptysis / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008258:Waldenstrom Macroglobulinemia / Q000175:diagnosis*; D014842:von Willebrand Diseases / Q000175:diagnosis*