Emphasis of neutrophil-to-lymphocyte ratio in non-metastatic renal cell carcinoma.
BACKGROUND
We investigated the prognostic significance of the neutrophil-to-lymphocyte ratio on overall survival and tumor stage in non-metastatic renal cell carcinoma.


METHODS
The records of 229 patients with non-metastatic RCC (T1-4N0M0) were retrospectively reviewed. Patients were classified as group 1 (T1 + T2) and group 2 (T3 + T4). The significance of the differences between the groups in terms of averages and median values were investigated with Student's t-test and Mann-Whitney U test, respectively.


RESULTS
Patients were divided in two as group 1 (T1 + T2) and group 2 (T3 + T4), consisting of 208 and 21 patients, respectively. Between the two groups, the neutrophil-to-lymphocyte ratio (NLR) was found as 2.83 ± 2.15 and 4.79 ± 4.65, respectively (p = 0.02). We found that NLR had a distinctive feature at a cut-off value of 2.9.


CONCLUSIONS
NLR was higher in local advanced tumors. We observed that the cut-off value of NLR is only associated with tumor volume.
Department of Urology, Clinic of Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara - Turkey.
Cavit
C
Ceylan
Ahmet
A
Camtosun
Omer Gokhan
OG
Doluoglu
Sedat
S
Tasdemir
Ibrahim
I
Keles
Erdogan
E
Aglamis
Can Ali
CA
Tatar
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D007680:Kidney Neoplasms / Q000097:blood* / Q000401:mortality / Q000473:pathology; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009504:Neutrophils; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012680:Sensitivity and Specificity