Transition metal-promoted biomimetic steps in total syntheses.
This review summarizes the state-of-the-art on the use of transition metals in synthetic steps inspired by biosynthesis. After an introduction showing the importance of metals in life processes, with special emphasis on biosynthetic processes, their place in biomimetic synthesis will be described. Topics include oxidative cyclizations for polyether synthesis, electrophilic and radical cyclizations of polyprenoids, the role of palladium in electrocyclizations, oxidative biaryl couplings and other rearrangement steps.
Muséum National d'Histoire Naturelle and Centre National de la Recherche Scientifique, Unité"Molécules de Communication et Adaptation des Micro-organismes" (UMR 7245 CNRS-MNHN), 57 rue Cuvier (CP 54), 75005 Paris, France. bnay@mnhn.fr.
Xu-Wen
XW
Li
Bastien
B
Nay
D032701:Biomimetics; D003500:Cyclization; D007501:Iron / Q000737:chemistry; D008345:Manganese / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D015394:Molecular Structure; D013455:Sulfur / Q000737:chemistry; D013729:Terpenes / Q000138:chemical synthesis* / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
D008670:Metals; D013729:Terpenes; D028561:Transition Elements; D008345:Manganese; D013455:Sulfur; D007501:Iron; D015032:Zinc