HLA restriction of carbamazepine-specific T-Cell clones from an HLA-A*31:01-positive hypersensitive patient.
HLA-A*31:01 is associated with carbamazepine (CBZ) hypersensitivity in Caucasian and Japanese populations. Herein, we show that HLA-A*31:01+ restricted the activation of carbamazepine-specific CD8(+) T-cells, which provides an immunological basis for the genetic association. Furthermore, CD4(+) T-cells were activated with carbamazepine in a HLA-DRB1*04:04-restricted manner, indicating that a common HLA haplotype may contribute to the multiclonal T-cell response seen in European patients with CBZ hypersensitivity.
Department of Molecular and Clinical Pharmacology, University of Liverpool , Sherrington Building, Ashton Street, Liverpool L69 3GE, England.
Maike
M
Lichtenfels
John
J
Farrell
Monday O
MO
Ogese
Catherine C
CC
Bell
Sidonia
S
Eckle
James
J
McCluskey
B Kevin
BK
Park
Ana
A
Alfirevic
Dean J
DJ
Naisbitt
Munir
M
Pirmohamed
D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002220:Carbamazepine / Q000009:adverse effects*; D002999:Clone Cells / Q000276:immunology; D004342:Drug Hypersensitivity / Q000276:immunology*; D015234:HLA-A Antigens / Q000276:immunology*; D006801:Humans
D015234:HLA-A Antigens; C069527:HLA-A31 antigen; D002220:Carbamazepine