Pure primary osteosarcoma of the breast: a case report.
BACKGROUND
Mammary sarcomas are relatively uncommon and they represent less than one percent of all primary breast malignancies. Osteosarcoma of the breast, unassociated with other tumors, is distinctly rare, with published references generally limited to case reports and occasional cases in several series encompassing a heterogeneous group of mammary sarcomas and extraosseous osteosarcomas at various sites. The authors present a patient with pure osteosarcoma of the breast, osteoblastic type, with biologically aggressive pattern.


METHODS
A 79-year-old lady became aware of a rapidly enlarging lump in the lateral part of the right breast. Clinical examination revealed a firm to hard, mobile, irregular, and painful breast lump measuring about six by four cm. On examination there was no axillary or supraclavicular lymphadenopathy. After initial diagnosis, excisional biopsy without dissection of the axillary lymph nodes was performed. Therefore, the histological and immunohistochemical findings established the diagnosis of pure primary osteosarcoma of the breast.


CONCLUSIONS
Pure osteosarcoma of the breast is extremely rare and needs to be distinguished from a variety of benign and malignant breast lesions producing metaplastic bone. Less than a hundred cases of pure osteosarcoma of the breast were reported, but diagnostic confirmation with immunohistochemistry has been performed in relatively few of these cases.
Surgery Clinic, Clinical Center Kragujevac, Kragujevac, Serbia.
S D
SD
Jakovljevic
Surgery Clinic, Clinical Center Kragujevac, Kragujevac, Serbia.
M B
MB
Spasic
Department of Pathology, Clinical Center Kragujevac, Kragujevac, Serbia.
M Z
MZ
Milosavljevic
Surgery Clinic, Clinical Center Kragujevac, Kragujevac, Serbia.
G L
GL
Azanjac
Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Z M
ZM
Protrka
Surgery Clinic, Clinical Center Kragujevac, Kragujevac, Serbia.
D M
DM
Radovanović
Department of Pathology, Clinical Center Kragujevac, Kragujevac, Serbia.
S L
SL
Mitrovic
D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000473:pathology*; D014463:Ultrasonography