Low-dose bevacizumab is effective in radiation-induced necrosis.
BACKGROUND
Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited.


METHODS
The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported.


RESULTS
Both patients with metastatic melanoma, aged 48 and 51 years, had significant symptomatic and radiological improvement with low-dose bevacizumab treatment. Doses as low as 5 mg/kg every 6 weeks and 7.5 mg/kg i.v. every 4 weeks were used and were highly effective.


CONCLUSIONS
Low-dose bevacizumab is a solid option in the management of edema associated with radiation necrosis.
Oncology Department, Hospital São José, São Paulo, Brazil.
Matheus
M
Alessandretti
Oncology Department, Hospital São José, São Paulo, Brazil.
Antonio C
AC
Buzaid
Oncology Department, Hospital São José, São Paulo, Brazil.
Raphael
R
Brandão
Oncology Department, Hospital São José, São Paulo, Brazil.
Erika P
EP
Brandão
Bevacizumab; Brain irradiation; Brain metastasis; Melanoma; Radiation-induced necrosis