The effect of agoraphobia on oxidative stress in panic disorder.
We aimed to investigate whether agoraphobia (A) in panic disorder (PD) has any effects on oxidative and anti-oxidative parameters. We measured total antioxidant capacity (TAC), paraoxonase (PON), arylesterase (ARE) antioxidant and malondialdehyde (MDA) oxidant levels using blood samples from a total of 31 PD patients with A, 22 PD patients without A and 53 control group subjects. There was a significant difference between the TAC, PON, ARE and MDA levels of the three groups consisting of PD with A, PD without A and the control group. The two-way comparison to clarify the group creating the difference showed that the TAC, PON, and ARE antioxidants were significantly lower in the PD with A group compared to the control group while the MDA oxidant was significantly higher. There was no significant difference between the PD without A and control groups for TAC, PON, ARE and MDA levels. We clearly demonstrated that the oxidative stress and damage to the anti-oxidative mechanism are significantly higher in the PD group with A. These findings suggest that oxidative/anti-oxidative mechanisms may play a more important role on the pathogenesis of PB with A.
Uskudar University, Department of Psychiatry, Istanbul, Turkey.
Isil Gogcegoz
IG
Gul
Inonu University Faculty of Medicine, Department of Psychiatry, Malatya, Turkey.
Rifat
R
Karlidag
Inonu University Faculty of Medicine, Department of Psychiatry, Malatya, Turkey.
Birgul Elbozan
BE
Cumurcu
Inonu University Faculty of Medicine, Department of Biochemistry, Malatya, Turkey.
Yusuf
Y
Turkoz
Inonu University Faculty of Medicine, Department of Psychiatry, Malatya, Turkey.
Sukru
S
Kartalci
Inonu University Faculty of Medicine, Department of Neurology, Malatya, Turkey.
A Cemal
AC
Ozcan
Inonu University Faculty of Medicine, Department of Biochemistry, Malatya, Turkey.
M Erman
ME
Erdemli
Agoraphobia; Free radical; Oxidative stress; Panic disorder; Total antioxidant capacity