Matrix metalloproteinase-7 and matrix metalloproteinase-25 in oral tongue squamous cell carcinoma.
BACKGROUND
Predicting the clinical course of early-stage oral tongue squamous cell carcinoma (SCC) is challenging. As matrix metalloproteinases (MMPs) are enzymes associated with invasion, metastasis, and poor survival in many cancers, we examined MMP-7 and MMP-25 in oral tongue SCC.


METHODS
We used tissue microarray (TMA) technique and immunohistochemistry to study the expression of MMP-7 and MMP-25 in 73 patients with stage I to II oral tongue SCC and compared their immunoexpressions with clinical data.


RESULTS
Immunohistochemistry revealed MMP-7 and MMP-25 expression in 90% (n = 63 of 70) and 90% (n = 64 of 71) of the tumors, respectively. MMP-7 protein expression was associated with presence of occult cervical metastases (odds ratio [OR], 3.67; p = .013), increased invasion depth (OR, 4.60; p = .005), and higher tumor grade (OR, 3.30; p = .007). MMP-7 expression was predictive for poor outcome (p = .021). Immunostaining of MMP-25 did not correlate with any clinical parameters.


CONCLUSIONS
We conclude that MMP-7, but not MMP-25, expression may have prognostic significance in early-stage oral tongue SCC.
Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Laura K
LK
Mäkinen
Valtteri
V
Häyry
Jaana
J
Hagström
Timo
T
Sorsa
Fabricio
F
Passador-Santos
Harri
H
Keski-Säntti
Jari
J
Haukka
Antti A
AA
Mäkitie
Caj
C
Haglund
Timo
T
Atula
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D058851:GPI-Linked Proteins / Q000378:metabolism; D006801:Humans; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism*; D053504:Matrix Metalloproteinases, Membrane-Associated / Q000378:metabolism*; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D046888:Tissue Array Analysis; D014062:Tongue Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D055815:Young Adult
D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; D053504:Matrix Metalloproteinases, Membrane-Associated; C403928:matrix metalloproteinase 25; D020783:Matrix Metalloproteinase 7
biomarker; immunohistochemistry; matrix metalloproteinase; oral cancer; prognosis