Stillbirth during infection with Middle East respiratory syndrome coronavirus.
We conducted an epidemiologic investigation among survivors of an outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in Jordan. A second-trimester stillbirth occurred during the course of an acute respiratory illness that was attributed to MERS-CoV on the basis of exposure history and positive results of MERS-CoV serologic testing. This is the first occurrence of stillbirth during an infection with MERS-CoV and may have bearing upon the surveillance and management of pregnant women in settings of unexplained respiratory illness potentially due to MERS-CoV. Future prospective investigations of MERS-CoV should ascertain pregnancy status and obtain further pregnancy-related data, including biological specimens for confirmatory testing.
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
Daniel C
DC
Payne
Jordan Field Epidemiology Training Program.
Ibrahim
I
Iblan
Communicable Diseases Directorate.
Sultan
S
Alqasrawi
Eastern Mediterranean Public Health Network, Amman, Jordan.
Mohannad
M
Al Nsour
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases Epidemic Intelligence Service.
Brian
B
Rha
Global Immunization Division, Center for Global Health.
Rania A
RA
Tohme
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
Glen R
GR
Abedi
Division of High Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases.
Noha H
NH
Farag
Directorate of Laboratories, Jordan Ministry of Health.
Aktham
A
Haddadin
Directorate of Laboratories, Jordan Ministry of Health.
Tarek
T
Al Sanhouri
Communicable Diseases Directorate.
Najwa
N
Jarour
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
David L
DL
Swerdlow
Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia.
Denise J
DJ
Jamieson
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
Mark A
MA
Pallansch
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
Lia M
LM
Haynes
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
Susan I
SI
Gerber
Communicable Diseases Directorate.
Mohammad Mousa
MM
Al Abdallat
D000293:Adolescent; D000328:Adult; D017934:Coronavirus / Q000302:isolation & purification*; D018352:Coronavirus Infections / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007597:Jordan; D011247:Pregnancy; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D012189:Retrospective Studies; D050497:Stillbirth / Q000453:epidemiology*; D055815:Young Adult
EMC-CoV; Jordan; MERS-CoV; Middle East respiratory syndrome; birth outcomes; novel coronavirus; pneumonia; pregnancy; severe acute respiratory illness; stillbirth