Methyltransferases modulate RNA stability in embryonic stem cells.
Emerging data support that RNA methylation plays important roles in RNA processing and metabolism. The methyltransferases Mettl3 and Mettl14 are shown to catalyse N(6)-methyladenosine (m(6)A) RNA modification in embryonic stem cells (ESCs). This m(6)A modification controls RNA metabolism and functions to destabilize mRNAs encoding developmental regulators to help sustain ESC self-renewal.
Stem Cell Program, Boston Children's Hospital, Massachusetts 02115, USA; the Department of Biological Chemistry and Molecular Pharmacology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA; and the Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA.
Shuibin
S
Lin
Stem Cell Program, Boston Children's Hospital, Massachusetts 02115, USA; the Department of Biological Chemistry and Molecular Pharmacology, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA; and the Harvard Stem Cell Institute, Boston, Massachusetts 02115, USA.
Richard I
RI
Gregory
D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D053595:Embryonic Stem Cells / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans
C010223:N-methyladenosine; D000241:Adenosine