Prognostic value of tissue factor in patients with abdominal aortic and iliac arterial aneurysms - preliminary study.
BACKGROUND
The decision on the time and choice of strategy of treatment of abdominal aortic aneurysm must be especially carefully balanced. The aim of the study was to evaluate the tissue factor (TF) plasma level as a potential factor useful in anticipation of abdominal aortic aneurysm and/or iliac arterial aneurysm via comparison of plasma TF level in patients with ruptured and non-ruptured aneurysms.


METHODS
The study included 33 patients with aneurysm (17 operated on electively because of non-ruptured aneurysm and 16 operated on emergently due to ruptured aneurysm), 33 claudicant patients with atherosclerosis of the abdominal aorta and iliac arteries with normal diameter of arteries, and 30 healthy controls. Plasma TF level was assessed by ELISA method using the IMUBIND Tissue Factor ELISA Kit (American Diagnostica Inc.).


RESULTS
The study showed an increased TF level in patients with aneurysm (134 ±54 pg/ml) and in patients with atherosclerosis without concomitant aneurysm (91 ±30 pg/ml) in comparison with the control group (62 ±20 pg/ml), respectively p < 0.001 and p = 0.008. A significantly higher TF plasma level was observed in patients with ruptured abdominal aortic aneurysms (160 ±57 pg/ml) as compared to patients with non-ruptured aortic aneurysms (109 ±39 pg/ml) or peripheral arterial occlusive disease (91 ±30 pg/ml), respectively p < 0.001 and p < 0.001. The difference in TF level between the group with non-ruptured aortic aneurysms (109 ±39 pg/ml) and the patients with atherosclerosis without aneurysm (91 ±30 pg/ml) was not statistically significant.


CONCLUSIONS
No difference in TF level between patients with non-ruptured AAA/IAA and patients with aortic and iliac atherosclerosis without aneurysm indicates that an increased TF plasma level is not specific for any of the above-mentioned vascular pathologies.
Department of Vascular, General and Transplantation Surgery, Wroclaw Medical University, Poland.
Jan
J
Skóra
Department of Vascular, General and Transplantation Surgery, Wroclaw Medical University, Poland.
Tomasz
T
Dawiskiba
Department of Vascular, General and Transplantation Surgery, Wroclaw Medical University, Poland.
Patrycja
P
Zaleska
Department of General Radiology, Interventional Radiology and Neuroradiology, Wroclaw Medical University, Poland.
Jacek
J
Kurcz
Department of Family Medicine, Wroclaw Medical University, Poland.
Agnieszka
A
Mastalerz-Migas
Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Poland.
Rajmund
R
Adamiec
Department of Angiology, Hypertension and Diabetology, Wroclaw Medical University, Poland.
Izabela
I
Gosk-Bierska
abdominal aorta; iliac artery; non-ruptured aneurysm; ruptured; tissue factor