Implications of chemokines, chemokine receptors, and inflammatory lipids in atherosclerosis.
Chemokines are a diverse group of molecules with important implications for the development of solid tissues and normal function of the immune system. However, change of the conditions for such a complex system can have important and dangerous consequences leading to diseases. The specific implications of the various chemokines in diseases have been elucidated in the last few years, prompting hope of manipulating this system for therapy or prevention of diseases. On the other hand, inflammatory lipids are biologically active molecules with crucial impacts on the function of various cell types, including immune cells in health and disease. Here, we describe how these lipids affect the chemokine system and how they interact with chemokines to shape chronic inflammation in the case of atherosclerosis.
1.Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, P.O. Box 1105, Blindern N-0317, Oslo, Norway. azzam.maghazachi@medisin.uio.no (A.A.M.) or johannes.rolin@medisin.uio.no (J.R.).
Johannes
J
Rolin
Azzam A
AA
Maghazachi
D000818:Animals; D050197:Atherosclerosis / Q000209:etiology*; D018925:Chemokines / Q000502:physiology*; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D008041:Linoleic Acids / Q000502:physiology; D044243:Linoleic Acids, Conjugated / Q000502:physiology; D008055:Lipids / Q000502:physiology*; D008077:Lipoproteins, LDL / Q000502:physiology; D008246:Lysophospholipids / Q000502:physiology; D019707:Receptors, Chemokine / Q000502:physiology*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000502:physiology
D018925:Chemokines; D008041:Linoleic Acids; D044243:Linoleic Acids, Conjugated; D008055:Lipids; D008077:Lipoproteins, LDL; D008246:Lysophospholipids; D019707:Receptors, Chemokine; C099252:oxidized low density lipoprotein; C024347:9-hydroxy-10,12-octadecadienoic acid; C060506:sphingosine 1-phosphate; C024348:13-hydroxy-9,11-octadecadienoic acid; D013110:Sphingosine
HODE; atherosclerotic plaque; linoleic acid; monocytes; sphingosine 1-phosphate; statins