Palladium-catalyzed oxidative carbonylation of N-allylamines for the synthesis of β-lactams.
β-Lactam scaffolds are considered to be ideal building blocks for the synthesis of nitrogen-containing compounds. A new palladium-catalyzed oxidative carbonylation of N-allylamines for the synthesis of α-methylene-β-lactams is reported. DFT calculations suggest that the formation of β-lactams via a four-membered-ring transition state is favorable.
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, (P. R. China) http://aiwenlei.whu.edu.cn/Main_Website/
Wu
W
Li
Chao
C
Liu
Heng
H
Zhang
Keyin
K
Ye
Guanghui
G
Zhang
Wangzheng
W
Zhang
Zhengli
Z
Duan
Shuli
S
You
Aiwen
A
Lei
D000499:Allylamine / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D047090:beta-Lactams / Q000138:chemical synthesis* / Q000737:chemistry
D047090:beta-Lactams; D000499:Allylamine; D010165:Palladium
allylic compounds; heterocycles; lactams; palladium; synthetic methods