Tooth-derived bone graft material.
With successful extraction of growth factors and bone morphogenic proteins (BMPs) from mammalian teeth, many researchers have supported development of a bone substitute using tooth-derived substances. Some studies have also expanded the potential use of teeth as a carrier for growth factors and stem cells. A broad overview of the published findings with regard to tooth-derived regenerative tissue engineering technique is outlined. Considering more than 100 published papers, our team has developed the protocols and techniques for processing of bone graft material using extracted teeth. Based on current studies and studies that will be needed in the future, we can anticipate development of scaffolds, homogenous and xenogenous tooth bone grafts, and dental restorative materials using extracted teeth.
Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea.
Young-Kyun
YK
Kim
Korea Tooth Bank, Seoul, Korea.
Junho
J
Lee
Korea Tooth Bank, Seoul, Korea.
In-Woong
IW
Um
Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Korea.
Kyung-Wook
KW
Kim
Department of Oral and Maxillofacial Surgery, Health Sciences University of Hokkaido, Sapporo, Japan.
Masaru
M
Murata
Department of Industrial Technology Research, Hokkaido Industrial Research Institute, Sapporo, Japan.
Toshiyuki
T
Akazawa
Takamatsu Oral and Maxillofacial Surgery Clinic, Kagawa, Japan.
Masaharu
M
Mitsugi
Bone substitutes; Demineralized dentin matrix; Dentin; Tissue engineering; Tooth