Expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the endometrium of patients with repeated implantation failure after in vitro fertilization.
OBJECTIVE
To compare the immunohistochemical expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in repeated implantation failure (RIF) patients with normal fertile controls.


METHODS
The study group consisted of primary infertile patients with RIF and normal fertile controls between January 2011 and February 2013. Endometrial samples received at the luteal phase were exposed to immunohistochemical staining for EMMPRIN antibodies. EMMPRIN expression of endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated. The main outcome measure was defined as immunohistochemical score with regard to the severity and extent of staining.


RESULTS
The study group consisted of 26 primary infertile patients, whereas the control group consisted of 40 normal fertile controls. The fertile group was found to have stronger expression of EMMPRIN than the study group when endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated with regards to the severity of staining (p < 0.001), the extent of staining (p < 0.001) and total staining score (p < 0.001).


CONCLUSIONS
This is the first study showing low expression of EMMPRIN in the endometrial cells of the patients with RIF compared with fertile healthy controls. We suggest that reduced EMMPRIN expression in the human endometrium may lead to poor endometrial receptivity.
Department of Obstetrics and Gynaecology, Dicle University School of Medicine, Diyarbakir, Turkey. abdulkadirturgut@gmail.com.
A
A
Turgut
N Y
NY
Goruk
S Y
SY
Tunc
E
E
Agaçayak
U
U
Alabalik
A
A
Yalinkaya
T
T
Gül
D000328:Adult; D051926:Basigin / Q000235:genetics* / Q000378:metabolism*; D016022:Case-Control Studies; D010064:Embryo Implantation / Q000502:physiology; D004717:Endometrium / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques / Q000379:methods; D007247:Infertility, Female / Q000235:genetics* / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism
C497886:BSG protein, human; D051926:Basigin