Potential role of omega-3-derived resolution mediators in metabolic inflammation.
In its most reduced form, metabolic inflammation can be best described as a maladaptive process that involves an integrated innate and acquired immune response to nutrient surplus. Although originally these events were thought to be restricted to the expanding adipose depots of obese individuals, there are increasing reports that other metabolic centers such as the gut, liver, skeletal muscle and hypothalamus are also foci for metabolic inflammation. This review presents an overview of the major events and players identified thus far as central components of metabolic inflammation, and will examine recent findings concerning a novel class of omega-3-derived bioactive lipids that suggest that altered resolution processes may also contribute to metabolic inflammation.
1] Department of Medicine, Québec Heart and Lung Institute, Ste-Foy, Québec, Canada [2] Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.
Phillip J
PJ
White
1] Department of Medicine, Québec Heart and Lung Institute, Ste-Foy, Québec, Canada [2] Institute of Nutrition and Functional Foods, Laval University, Québec City, Québec, Canada.
André
A
Marette
D000818:Animals; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism*; D008954:Models, Biological; D009928:Organ Specificity; D051192:Receptors, Pattern Recognition / Q000378:metabolism
D015525:Fatty Acids, Omega-3; D051192:Receptors, Pattern Recognition