Presumed solitary intraocular or conjunctival lymphoma in dogs and cats: 9 cases (1985-2013).
OBJECTIVE
To determine prevalence, reason for evaluation, treatment, and outcome for dogs and cats with presumed solitary ocular lymphoma (PSOL).


METHODS
Retrospective case series.


METHODS
7 dogs and 2 cats with PSOL.


METHODS
Medical records were reviewed. Progression-free survival time (PFST) and overall survival time (OST) were determined.


RESULTS
Animals with intraocular (4 dogs and 1 cat) or conjunctival (3 dogs and 1 cat) lymphoma represented 0.1% and 0.08% of patients with lymphoma evaluated at the hospital during the study period, respectively. Animals with intraocular lymphoma represented 0.19% of all patients with uveitis; animals with conjunctival lymphoma represented 0.16% of all patients with conjunctivitis. Tumors included B-cell (2 intraocular and 1 conjunctival), non-B-cell, non-T-cell (1 intraocular), and T-cell (3 conjunctival) neoplasms; immunophenotype of 2 uveal lymphomas was not determined. Treatments included enucleation (4 intraocular) and chemotherapy (3 intraocular and 2 conjunctival). All dogs with intraocular lymphoma developed neurologic signs. Lymph node metastasis was detected in 2 patients with conjunctival lymphoma. Median PFST and OST were 178 days for all animals with PSOL, dogs with PSOL, and animals with intraocular lymphoma. Median PFST and OST for animals with conjunctival lymphoma were 221 and 549 days, respectively.


CONCLUSIONS
Results indicated PSOL was uncommon, but should be considered a differential diagnosis for animals with uveitis or conjunctivitis. Performance of MRI and cytologic analysis of CSF and regional lymph node aspirate samples may be beneficial for such patients. Prognosis seemed to be better for animals with conjunctival lymphoma than it was for those with intraocular lymphoma.
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523.
K Tomo
KT
Wiggans
Katherine A
KA
Skorupski
Christopher M
CM
Reilly
Sara A
SA
Frazier
Richard R
RR
Dubielzig
David J
DJ
Maggs
D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis* / Q000473:pathology; D002415:Cats; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005134:Eye Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008223:Lymphoma / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies