Lateral junction dynamics lead the way out.
Epithelial cell layers need to be tightly regulated to maintain their integrity and correct function. Cell integration into epithelial sheets is now shown to depend on the N-WASP-regulated stabilization of cortical F-actin, which generates distinct patterns of apical-lateral contractility at E-cadherin-based cell-cell junctions.
Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Martin
M
Behrndt
Institute of Science and Technology Austria, Am Campus 1, 3400 Klosterneuburg, Austria.
Carl-Philipp
CP
Heisenberg
D000199:Actins / Q000502:physiology*; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism*
D000199:Actins