Synthesis, crystal structure and potential antimicrobial activities of di (4-sulfamoyl-phenyl-ammonium) sulphate.
A new organic-inorganic hybrid SO4[C6H9N2O2S]2, has been synthesized and characterized by X-ray diffraction. This compound crystallizes in the orthorhombic system, spaces group Pbcn. In the title compound, the packing is stabilized by intermolecular N-H⋯O hydrogen bonds and π-π stacking interactions between the phenyl rings, linking the molecules into three-dimensional network. The in vitro antimicrobial activity of di (4-sulfamoyl-phenyl-ammonium) sulphate was determined by the broth dilution method against several strains selected to define their spectrum and potency. Here we show that the synthetic sulfanilamide exhibits promising antibacterial potency. High inhibition was also detected against Candida albicans. In this paper we firstly showed the antifungal activity of the sulfanilamide against two serious phytopathogenic fungi. Interestingly, the new compound was able to suppress mycelial growth as well as the spores germination of tested fungi, values of spore germination vary from 97.6% to 37.5%, respectively for Botrytis cinerea and Fusarium species. The minimal inhibitory concentrations (MIC) ranging from 8 to 100 μg ml(-1) and IC50 values varying from 5.81 to less than 100 μg ml(-1)), showed that the sulfanilamide sulphate had high activity against bacteria, yeast and fungi, compared to others published antifungal compounds.
Laboratoire Microorganismes et Biomolécules Actives, Faculté des Sciences, 2092 El Manar, Tunis, Tunisia. Electronic address: badiaaessghaier@gmail.com.
Badiaa
B
Essghaier
Laboratoire Microorganismes et Biomolécules Actives, Faculté des Sciences, 2092 El Manar, Tunis, Tunisia.
Amani
A
Naouar
Laboratoire de Matériaux et Cristallochimie, Département de chimie, Faculté des Sciences, 2092 El Manar, Tunis, Tunisia.
Jawher
J
Abdelhak
Laboratoire de Matériaux et Cristallochimie, Département de chimie, Faculté des Sciences, 2092 El Manar, Tunis, Tunisia.
Mohamed Faouzi
MF
Zid
Laboratoire Microorganismes et Biomolécules Actives, Faculté des Sciences, 2092 El Manar, Tunis, Tunisia.
Najla
N
Sadfi-Zouaoui
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D000077145:Sulfanilamide; D013424:Sulfanilamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D013424:Sulfanilamides; D000077145:Sulfanilamide
Antifungal activity; Single crystal structure; Spores germination inhibition; Sulfanilamide