[Efficacy of intravenous dexketoprofen trometamol compared to intravenous paracetamol for postoperative pain management after day-case operative hysteroscopy: randomized, double-blind, placebo-controlled study].
OBJECTIVE
Adequate pain management following day-case surgery allows early ambulation of patients. In this study, we aimed to compare postoperative analgesic efficacy of intravenous (iv) dexketoprofen vs. iv paracetamol following day-case operative hysteroscopy.


METHODS
One hundred and fourteen American Society of Anesthesiologists (ASA) I-II patients scheduled for day-case operative hysteroscopy were recruited and randomized to three groups in the study. Group D received 50 mg iv dexketoprofen trometamol, Group P 1000 mg iv paracetamol and Group C normal saline solution. Visual Analogue Scale (VAS) pain intensity, pain relief, sedation, nausea-vomiting, other side effects, and additional opioid analgesic requirement were noted at postoperative 15 minutes (min), 30 min, 1 hour (h), 2 h, and 3 h. Patients with VAS>=40 mm received meperidine 0.25 mg/kg as rescue analgesic medication.


RESULTS
VAS scores at 15 min, 30 min, 1 h, and 2 h were significantly lower in Group D compared to Group C. VAS scores at 15 min and 30 min were significantly lower in Group D compared to Group P. The percentages of patients who required opioid treatment were 34%, 60%, and 63% in Groups D, P and C, respectively (p<0.05). Total delivered opioid dose was 0.10±0.16 mg/kg, 027±0.33 mg/kg and 0.28±0.25 mg/kg in Groups D, P and C, respectively (p<0.05). Pain relief score was significantly better in Group D at postoperative 15 min when compared with Group C (p<0.05).


CONCLUSIONS
Our study demonstrated that iv dexketoprofen has superior efficacy for postoperative pain management following day-case operative hysteroscopy when compared with paracetamol and placebo.
Department of Anesthesiology and Reanimation, Başkent University Faculty of Medicine, Ankara, Turkey. aysukocum@gmail.com.
Aysu
A
Koçum
Department of Anesthesiology and Reanimation, Başkent University Faculty of Medicine, Ankara, Turkey.
Mesut
M
Sener
Department of Anesthesiology and Reanimation, Başkent University Faculty of Medicine, Ankara, Turkey.
Hatice
H
Izmirli
Department of Obstetrics and Gynecology, Başkent University Faculty of Medicine, Ankara, Turkey.
Bülent
B
Haydardedeoğlu
Department of Anesthesiology and Reanimation, Başkent University Faculty of Medicine, Ankara, Turkey.
Anış
A
Arıboğan
D000082:Acetaminophen / Q000008:administration & dosage*; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007262:Infusions, Intravenous; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D016896:Treatment Outcome; D014325:Tromethamine / Q000008:administration & dosage*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D000082:Acetaminophen; D007660:Ketoprofen; C118296:dexketoprofen trometamol