Prevalence of and potential risk factors for mild cognitive impairment in community-dwelling residents of Beijing.
OBJECTIVE
To estimate the prevalence of mild cognitive impairment (MCI) in Beijing, China, and to explore the potential protective and risk factors for MCI.


METHODS
Population-based survey.


METHODS
The Beijing Ageing Brain Rejuvenation Initiative (BABRI).


METHODS
Participants randomly recruited from BABRI (N=1,211).


METHODS
Participants underwent a battery of neuropsychological examinations to determine cognitive function and answered a series of personal questions. The prevalence of MCI and its subtypes were computed using Petersen's criteria. Influencing factors for MCI were estimated based on participant medical history, lifestyle, diet, and leisure activities.


RESULTS
One thousand twenty (aged>55, mean 63.9±6.6; 36.7% male) subjects completed the neuropsychological tests. The overall prevalence of MCI was 15.7%, with single-domain amnestic, multiple-domain amnestic, and nonamnestic subtype prevalences of 6.4%, 3.7%, and 5.6%, respectively. Eight hundred sixty-four subjects were used for the case–control analysis. Hypertension, diabetes mellitus, and cerebrovascular disease were found to be associated with MCI. Healthy diet and greater involvement in physical, intellectual, and social activities were associated with a lower risk of MCI.


CONCLUSIONS
The prevalence of MCI was compatible with that found in previous published reports, and the information on the epidemiology of MCI, especially risk factors, may help to explore therapeutic strategies and preventive approaches to delay conversion to dementia.
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Xin
X
Li
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Chao
C
Ma
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Junying
J
Zhang
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Ying
Y
Liang
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Yaojing
Y
Chen
Department of Psychiatry, Banner Alzheimer's Institute, Phoenix, Arizona.
Kewei
K
Chen
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Jun
J
Wang
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Zhanjun
Z
Zhang
Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China.
Yongyan
Y
Wang
D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D060825:Cognitive Dysfunction / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires