[Blood lipid, glucose and uric acid in people with subclinical hypothyroidism].
OBJECTIVE
To investigate the changes of blood lipid, fasting blood glucose and blood uric acid and its clinical significance in people with subclinical hypothyroidism.


METHODS
Body mass index (BMI), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free tetraiodothyronine (FT4), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG) and uric acid (UA) were measured and compared in 356 people with subclinical hypothyroidism and 331 health people (controls).


RESULTS
Compared to the control group, people with subclinical hypothyroidism had higher levels of BMI, TSH, TC, LDL-C, TG, FBG, UA (P < 0.05) and non-significant decrease of HDL-C (P > 0.05). The level of TSH was positively correlated with TC (r = 0.254), LDL-C (r = 0.110), TG (r = 0.218), BMI (r = 0.119) and FBG (r = 0.210) (P < 0.05). The level of HDL-C was not correlated with TSH (P > 0.05).


CONCLUSIONS
Thyroid dysfunction may have an effect on the metabolism of blood lipid, FBG and UA.
Department of General Practice Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Li-Bo
LB
Liang
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Mei
M
Zhang
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Heng-Jian
HJ
Huang
Department of Physical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, China.
You-Juan
YJ
Wang
Department of General Practice Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Shuang-Qing
SQ
Li
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000145:classification; D008055:Lipids / Q000097:blood*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*
D001786:Blood Glucose; D008055:Lipids; D014527:Uric Acid