Acoustic emission monitoring from a lab scale high shear granulator--a novel approach.
A new approach to the monitoring of granulation processes using passive acoustics together with precise control over the granulation process has highlighted the importance of particle-particle and particle-bowl collisions in acoustic emission. The results have shown that repeatable acoustic results could be obtained but only when a spray nozzle water addition system was used. Acoustic emissions were recorded from a transducer attached to the bowl and an airborne transducer. It was found that the airborne transducer detected very little from the granulation and only experienced small changes throughout the process. The results from the bowl transducer showed that during granulation the frequency content of the acoustic emission shifted towards the lower frequencies. Results from the discrete element model indicate that when larger particles are used the number of collisions the particles experience reduces. This is a result of the volume conservation methodology used in this study, therefore larger particles results in less particles. These simulation results coupled with previous theoretical work on the frequency content of an impacting sphere explain why the frequency content of the acoustic emissions reduces during granule growth. The acoustic system used was also clearly able to identify when large over-wetted granules were present in the system, highlighting its benefit for detecting undesirable operational conditions. High-speed photography was used to study if visual changes in the granule properties could be linked with the changing acoustic emissions. The high speed photography was only possible towards the latter stages of the granulation process and it was found that larger granules produced a higher magnitude of acoustic emission across a broader frequency range.
Department of Food Science and Nutrition, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK. Electronic address: n.j.watson@leeds.ac.uk.
N J
NJ
Watson
Department of Food Science and Nutrition, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.
M J W
MJ
Povey
Pharmaceutical Development, AstraZeneca, Silk Road Business Park, Macclesfield SK10 2NA, UK.
G K
GK
Reynolds
Institute of Particle Science and Engineering, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.
B H
BH
Xu
Institute of Particle Science and Engineering, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.
Y
Y
Ding
D000162:Acoustics / Q000295:instrumentation; D002482:Cellulose / Q000737:chemistry*; D004867:Equipment Design; D009038:Motion; D010316:Particle Size; D011208:Powders; D012815:Signal Processing, Computer-Assisted; D013016:Sound; D013018:Sound Spectrography; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*; D013997:Time Factors; D014159:Transducers; D014867:Water / Q000737:chemistry
D011208:Powders; D014867:Water; D002482:Cellulose; C109691:microcrystalline cellulose
Discrete element monitoring; Granulation; High shear mixer; High speed photography; Passive acoustic monitoring; Process monitoring