Direct writing of bio-functional coatings for cardiovascular applications.
The surface modification of metallic biomaterials is of critical importance to enhance the biocompatibility of surgical implant materials and devices. This article investigates the use of a direct-write inkjet technique for multilayer coatings of a biodegradable polymer (polyester urethane urea (PEUU)) embedded with an anti-proliferation drug paclitaxel (Taxol). The direct-write inkjet technique provides selective patterning capability for depositing multimaterial coatings on three-dimensional implant devices such as pins, screws, and stents for orthopedic and vascular applications. Drug release profiles were studied to observe the influence of drug loading and coating thickness for obtaining tunable release kinetics. Platelet deposition studies were conducted following ovine blood contact and significant reduction in platelet deposition was observed on the Taxol loaded PEUU substrate compared with the unloaded control. Rat smooth muscle cells were used for cell proliferation studies. Significant reduction in cell growth was observed following the release of anti-proliferative drug from the biopolymer thin film. This research provides a basis for developing anti-proliferative biocompatible coatings for different biomedical device applications.
Department of Industrial and Systems Engineering, North Carolina A&T State University, 1601 E. Market St, Greensboro, North Carolina, 27411; Engineering Research Center for Revolutionizing Metallic Biomaterials, North Carolina A&T State University, 1601 E. Market St., Greensboro, North Carolina, 27411.
Jessica
J
Perkins
Yi
Y
Hong
Sang-Ho
SH
Ye
William R
WR
Wagner
Salil
S
Desai
D000818:Animals; D063566:Biodegradable Plastics / Q000737:chemistry / Q000494:pharmacology; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D049109:Cell Proliferation; D020099:Coated Materials, Biocompatible / Q000737:chemistry / Q000494:pharmacology; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism*; D010973:Platelet Adhesiveness; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D066330:Printing, Three-Dimensional; D051381:Rats; D012756:Sheep
D063566:Biodegradable Plastics; D020099:Coated Materials, Biocompatible; D011091:Polyesters; C497893:poly(ester urethane)urea
anti-proliferative; bio-functional coatings; cardiovascular devices; direct write inkjet; elastomeric polymer