Association of IL-6-174G > C and -572C > G polymorphisms with risk of young ischemic stroke patients.
OBJECTIVE
To investigate the association between interleukin-6 (IL-6) -174G>C and -572C>G polymorphisms and risk for ischemic stroke (IS) in young patients.


METHODS
We genotyped IL-6 -174G>C and -572C>G in a case-control study of 430 young IS patients and 461 control subjects. An unconditional multiple logistical regression model was used to calculate the effects of IL-6-174G>C and -572C>G polymorphisms on IS risk.


RESULTS
Higher body mass index, diabetes, hypertension, obesity, and smoking were associated with risk of ischemic stroke. Multivariate regression analyses showed that subjects carrying the -174CC genotype (OR=1.69, 95% CI=1.16-2.57) and C allele (OR=1.37, 95% CI=1.09-1.67) had a small but significant increased risk of IS. Similarly, those carrying the -572GG genotype (OR=2.12, 95% CI=1.18-3.82) and G allele (OR=1.43, 95% CI=1.14-1.83) had a moderate increased risk of IS. We found the -174G>C and -572C>G polymorphisms interact with hypertension and obesity.


CONCLUSIONS
Our results suggest that polymorphisms in IL-6-174G>C and -572C>G are associated with IS risk in young patients, and that these polymorphisms interact with hypertension, obesity and etiologic subtypes. These findings could be helpful in identifying individuals at increased risk for developing IS.
Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266000, China. Electronic address: yangxuan_qdh@163.com.
Xuan
X
Yang
Diagnostic Imaging Division, Qingdao Municipal Hospital, Qingdao 266000, China.
Lei
L
Feng
Intensive Care Unit, Qingdao Central Hospital, Qingdao 266000, China.
Changjiang
C
Li
Zibo Municipal Hospital Authorities Internal Medicine, Zibo 255000, China.
Yu
Y
Li
D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D002545:Brain Ischemia / Q000209:etiology*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D020521:Stroke / Q000209:etiology*
D015415:Biomarkers; D015850:Interleukin-6
Interleukin-6; Ischemic stroke; Polymorphism; Risk