A conversion formula for comparing pulse oximeter desaturation rates obtained with different averaging times.
OBJECTIVE
The number of desaturations determined in recordings of pulse oximeter saturation (SpO2) primarily depends on the time over which values are averaged. As the averaging time in pulse oximeters is not standardized, it varies considerably between centers. To make SpO2 data comparable, it is thus desirable to have a formula that allows conversion between desaturation rates obtained using different averaging times for various desaturation levels and minimal durations.


METHODS
Oxygen saturation was measured for 170 hours in 12 preterm infants with a mean number of 65 desaturations <90% per hour of arbitrary duration by using a pulse oximeter in a 2-4 s averaging mode. Using 7 different averaging times between 3 and 16 seconds, the raw red-to-infrared data were reprocessed to determine the number of desaturations (D). The whole procedure was carried out for 7 different minimal desaturation durations (≥ 1, ≥ 5, ≥ 10, ≥ 15, ≥ 20, ≥ 25, ≥ 30 s) below SpO2 threshold values of 80%, 85% or 90% to finally reach a conversion formula. The formula was validated by splitting the infants into two groups of six children each and using one group each as a training set and the other one as a test set.


RESULTS
Based on the linear relationship found between the logarithm of the desaturation rate and the logarithm of the averaging time, the conversion formula is: D2 = D1 (T2/T1)(c), where D2 is the desaturation rate for the desired averaging time T2, and D1 is the desaturation rate for the original averaging time T1, with the exponent c depending on the desaturation threshold and the minimal desaturation duration. The median error when applying this formula was 2.6%.


CONCLUSIONS
This formula enables the conversion of desaturation rates between different averaging times for various desaturation thresholds and minimal desaturation durations.
Children's Hospital, Department of Neonatology, University of Tübingen, Tübingen, Germany ; ARCIM-Institute, Research Department, Filderklinik, Filderstadt, Germany.
Jan
J
Vagedes
Children's Hospital, Department of Neonatology, University of Tübingen, Tübingen, Germany.
Anja
A
Bialkowski
Children's Hospital, Department of Neonatology, University of Tübingen, Tübingen, Germany.
Cornelia
C
Wiechers
Children's Hospital, Department of Neonatology, University of Tübingen, Tübingen, Germany.
Christian F
CF
Poets
Department of Medical Biometry, University of Tübingen, Tübingen, Germany.
Klaus
K
Dietz
D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000097:blood*; D012016:Reference Values
D010100:Oxygen