Cu-catalyzed amidation of halogenated imidazoles.
An efficient methodology involving the Cu-catalyzed amidation of halogenated imidazoles has been successfully developed. The amidated product of 5-bromo-1-alkylimidazole was further applied to the synthesis of a new chiral imidazole nucleophilic catalyst for the kinetic resolution of secondary alcohols.
School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China. wanbin@sjtu.edu.cn.
Mo
M
Wang
Zhenfeng
Z
Zhang
Fang
F
Xie
Wanbin
W
Zhang
D000438:Alcohols / Q000737:chemistry; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure
D000438:Alcohols; D000577:Amides; D007093:Imidazoles; D003300:Copper