The effects of transoral incisionless fundoplication on chronic GERD patients: 12-month prospective multicenter experience.
OBJECTIVE
This study aimed to assess the impact of transoral incisionless fundoplication (TIF) on patients with chronic gastroesophageal reflux disease (GERD) at 12-month follow-up.


METHODS
Clinical outcomes of 100 consecutive patients with chronic GERD who underwent TIF between January 2010 and February 2011 were analyzed.


RESULTS
There were no major complications reported. Esophageal acid exposure was normalized in 14/27 (52%) of patients who underwent 12-month pH testing. Seventy-four percent of all patients were off proton pump inhibitors versus 92% on daily proton pump inhibitors before TIF, P<0.001. Daily bothersome heartburn and regurgitation symptoms were eliminated in 66/85 (78%) and 48/58 (83%) of patients. Median reflux symptom index score was reduced from 20 (0 to 41) to 5 (0 to 44), P<0.001. Two patients reported de novo dysphagia and 1 patient reported bloating (scores 0 to 3). Six patients underwent revision; 5 laparoscopic Nissen fundoplication and 1 TIF.


CONCLUSIONS
TIF provided a safe and effective therapeutic option for carefully selected patients with chronic GERD.
*Department of Surgery, The University of Texas Health Science Center, Houston ¶Master Center for Minimally Invasive Surgery, Southlake #Ihde Surgical Group, Arlington, TX †Livingston Hospital and Healthcare Services Inc., CAH, Salem, KY ‡Internal Medicine Associates, Merrillville, IN §Mt Graham Regional Medical Center, Safford ##Tempe St Luke's Hospital, Tempe, AZ ∥SurgOne Foregut Institute, Englewood, CO **Allegan Surgical Associates, Allegan, MI ††Munroe Regional Medical Center, Ocala, FL ‡‡Utah County Surgical Associates, Orem, UT §§Crossville Medical Group, PA, Crossville, TN ∥∥Department of Surgery, The George Washington University School of Medicine & Health Sciences, Washington, DC ¶¶Reston Surgical Associates, Reston, VA ***The Surgeons Group of Baton Rouge, Baton Rouge, LA †††EndoGastric Solutions Inc., Redmond, WA.
Erik B
EB
Wilson
William E
WE
Barnes
Peter G
PG
Mavrelis
Bart J
BJ
Carter
Reginald C W
RC
Bell
Robert W
RW
Sewell
Glenn M
GM
Ihde
David
D
Dargis
Kevin M
KM
Hoddinott
Ahmad B
AB
Shughoury
Brian D
BD
Gill
Mark A
MA
Fox
Daniel G
DG
Turgeon
Katherine D
KD
Freeman
Tanja
T
Gunsberger
Mark G
MG
Hausmann
Karl A
KA
Leblanc
Emir
E
Deljkich
Karim S
KS
Trad
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D057605:Natural Orifice Endoscopic Surgery / Q000379:methods*; D011446:Prospective Studies; D011788:Quality of Life; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult