[Analysis of questionably allergic factors to parenterally administered shenmai--a nested case control study using hospital information system data].
Parenterally administered Shenmai, made from constituents of Ginseng Rubra Radix and Ophiopogonis Radix has, confirmed by modem pharmacological studies, the function of increasing cardiac hypoxia tolerance and anti arrhythmic and antibacterial properties. However, parenterally administered Shenmai is also prone to cause allergic reactions, which is clearly a safety issue. NCCSs combine elements from case-control and cohort studies. HIS data provides real world clinical information on the use of parenterally administered Shenmai. To explore suspected allergic factors this article compares specific information of those who showed allergies to those who didnt in the real world clinical application based on HIS data from 20 nationwide hospitals. Data includes age, gender, severity and type of allergic response, dosage, solvents used in the medication's preparation and drugs used in combination with parenterally administered Shenmai. Whilst this methodology is a possible route of exploration, ultimately pharmaceutical experiments and prospective clinical studies are required to identify and confirm factors related to allergic reactions.
Institute of Basic Research in Clinical Medcine, China Academy of Chinese Medical Sciences, Beijing 100700, China. wanglianxin_tcm@126.com
Lian-Xin
LX
Wang
Renmin University of China, Beijing 100872, China.
Hao
H
Tang
Institute of Basic Research in Clinical Medcine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yan-Ming
YM
Xie
Institute of Basic Research in Clinical Medcine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Wei
W
Yang
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004342:Drug Hypersensitivity / Q000209:etiology*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006751:Hospital Information Systems / Q000706:statistics & numerical data*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D064792:Pragmatic Clinical Trials as Topic; D011446:Prospective Studies; D055815:Young Adult
D004365:Drugs, Chinese Herbal