π-Complexation in nickel-catalyzed cross-coupling reactions.
The kinetic isotope effect (KIE) is used to experimentally elucidate the first irreversible step in oxidative addition reactions of a zerovalent nickel catalyst to a set of haloarene substrates. Halogenated o-methylbenzene, dimethoxybenzene, and thiophene derivatives undergo intramolecular oxidative addition through irreversible π-complexation. Density functional theory computations at the B3LYP-D3/TZ2P-LANL2TZ(f)-LANL08d level predict η(2)-bound π-complexes are generally stable relative to a solvated catalyst plus free substrate and that ring-walking of the Ni(0) catalyst and intramolecular oxidative addition are facile in these intermediates.
Department of Chemistry, ‡Center for Computational Chemistry, and §College of Engineering, University of Georgia , Athens, Georgia 30602, United States.
S Kyle
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Sontag
Jenna A
JA
Bilbrey
N Eric
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Huddleston
Gareth R
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Sheppard
Wesley D
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Allen
Jason
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Locklin