Microfluidic assembly of multistage porous silicon-lipid vesicles for controlled drug release.
A reliable microfluidic platform for the generation of stable and monodisperse multistage drug delivery systems is reported. A glass-capillary flow-focusing droplet generation device was used to encapsulate thermally hydrocarbonized porous silicon (PSi) microparticles into the aqueous cores of double emulsion drops, yielding the formation of a multistage PSi-lipid vesicle. This composite system enables a large loading capacity for hydrophobic drugs.
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland. helder.santos@helsinki.fi.
Bárbara
B
Herranz-Blanco
Laura R
LR
Arriaga
Ermei
E
Mäkilä
Alexandra
A
Correia
Neha
N
Shrestha
Sabiruddin
S
Mirza
David A
DA
Weitz
Jarno
J
Salonen
Jouni
J
Hirvonen
Hélder A
HA
Santos
D006801:Humans; D008027:Light; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation / Q000379:methods; D055668:Photochemical Processes; D011173:Portraits as Topic; D018508:Water Purification / Q000295:instrumentation / Q000379:methods