Evaluation of neostigmine antagonism at different levels of vecuronium-induced neuromuscular blockade in isoflurane anesthetized dogs.
Residual neuromuscular block (NMB) during recovery from general anesthesia may be minimized by antagonizing NMB with neostigmine. We examined neostigmine for restoring neuromuscular function when administered at 2 levels of vecuronium-induced NMB in dogs. Eight healthy adult dogs received vecuronium 0.1 mg/kg body weight (BW), IV, during isoflurane anesthesia. Recovery from vecuronium occurred spontaneously (control group; C), or was enhanced with neostigmine, 0.04 mg/kg BW, IV, administered when 2 (N2) or 4 (N4) responses to train-of-four (TOF) stimulation were first observed. Duration of NMB was significantly shorter for N2 and N4 than for C. The period of complete NMB was equal for all groups; differences were observed during the recovery phase of NMB. Time of neostigmine-enhanced recovery was significantly shorter for N4 than N2, but overall duration of NMB was not reduced. Recovery from NMB was faster with neostigmine. There is no clinical advantage in delaying neostigmine administration once 2 responses to TOF are present.
Cátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Baldivieso, Himelfarb, Litterio); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Augusto M
AM
Lorenzutti
Cátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Baldivieso, Himelfarb, Litterio); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Manuel
M
Martin-Flores
Cátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Baldivieso, Himelfarb, Litterio); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Juan M
JM
Baldivieso
Cátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Baldivieso, Himelfarb, Litterio); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Martín A
MA
Himelfarb
Cátedra de Farmacología y Toxicología, Facultad de Ciencias Agropecuarias, Universidad Católica de Córdoba, Argentina (Lorenzutti, Baldivieso, Himelfarb, Litterio); Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA (Martin-Flores).
Nicolás J
NJ
Litterio
D018685:Anesthetics, Inhalation / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D005260:Female; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D009388:Neostigmine / Q000627:therapeutic use*; D019148:Neuromuscular Blockade / Q000662:veterinary*; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D014673:Vecuronium Bromide / Q000494:pharmacology*
D018685:Anesthetics, Inhalation; D003473:Neuromuscular Nondepolarizing Agents; D009388:Neostigmine; D014673:Vecuronium Bromide; D007530:Isoflurane