Synthetic aminomethylnaphthoquinones inhibit the in vitro replication of bovine herpesvirus 5.
Bovine herpesvirus type 5 (BoHV-5) is an etiologic agent of meningoencephalitis in cattle. The aim of this study was to evaluate the antiviral potential of a series of synthetic Mannich bases derived from lawsone and to investigate at which stage of the BoHV-5 replicative cycle the compounds might be acting. The most potent and selective inhibitor exhibited CC50 and EC50 values of 1867 μM ± 8.3 and 3.8 μM ± 1.2, respectively (ACV: 989 μM ± 2 and 166 μM ± 2, respectively).
Instituto Biomédico, Universidade Federal Fluminense, Rua Professor Hernani Melo, 101, São Domingos, Niterói, RJ, CEP 24210-130, Brazil, anapintoj26@gmail.com.
Ana Maria V
AM
Pinto
José Paulo G
JP
Leite
Amanda P
AP
Neves
Gustavo B
GB
da Silva
Maria D
MD
Vargas
Izabel Christina N P
IC
Paixão
D000212:Acyclovir / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D025881:Herpesvirus 5, Bovine / Q000187:drug effects* / Q000502:physiology; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D009285:Naphthoquinones; D000212:Acyclovir