Insulin analogue therapy improves quality of life in patients with type 2 diabetes in India: the A1chieve study.
OBJECTIVE
To determine the effects on quality of life after starting insulin with, or switching to, insulin analogue therapies in Indians with type 2 diabetes mellitus in the 24-week, prospective, observational A1chieve study.


METHODS
Health-related quality of life (HRQoL) was assessed at baseline and at 24 weeks by the validated EQ-5D questionnaire (visual analogue score [VAS] and five dimensions) in 20,554 people who had started using basal insulin detemir, mealtime insulin aspart (with or without a basal insulin) or biphasic insulin aspart 30.


RESULTS
Quality of life improved in both insulin-naive and insulin experienced patients in all treatment groups. At the start of the study, 63.2% of the insulin-naive patients reported problems with walking but after 24 weeks, only 15.2% reported difficulties. At baseline all HrQOL parameters were deteriorated in Indian cohort and the improvement observed was highly significant and well appreciated. The improvement was seen across all insulin regimen and all regions around India.


CONCLUSIONS
Compared with baseline scores, HRQoL improvement was seen after 24 weeks of treatment with all insulin analogue therapies
Institute of Diabetology, Madras Medical College, Chennai.
Anand
A
Moses
North Delhi Diabetes Centre, New Delhi.
Rajeev
R
Chawla
Providence Endocrine and Diabetes Specialty Centre, Trivandrum 695011.
Matthew
M
John
D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000209:etiology; D061265:Biphasic Insulins / Q000627:therapeutic use*; D003863:Depression / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007194:India; D061267:Insulin Aspart / Q000627:therapeutic use*; D000069057:Insulin Detemir; D049528:Insulin, Long-Acting / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology; D016138:Walking
D061265:Biphasic Insulins; D007004:Hypoglycemic Agents; D049528:Insulin, Long-Acting; D000069057:Insulin Detemir; D061267:Insulin Aspart