Seven hours to adequate antimicrobial therapy in urosepsis using isothermal microcalorimetry.
Urosepsis can progress toward severe sepsis, septic shock, and, ultimately, death. Rapid antimicrobial susceptibility testing is crucial to decrease mortality and morbidity. This report shows that isothermal microcalorimetry can provide an antibiogram within 7 h with a sensitivity of 95% and specificity of 91% using Vitek-2 system as a reference.
Department of Urology, University Hospital Basel, Basel, Switzerland.
Olivier
O
Braissant
Georg
G
Müller
Adrian
A
Egli
Andreas
A
Widmer
Reno
R
Frei
Armin
A
Halla
Dieter
D
Wirz
Thomas C
TC
Gasser
Alexander
A
Bachmann
Florian
F
Wagenlehner
Gernot
G
Bonkat
D002151:Calorimetry / Q000379:methods*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods*; D012680:Sensitivity and Specificity; D013995:Time; D014552:Urinary Tract Infections / Q000175:diagnosis* / Q000382:microbiology*