Incidence of malignancies in patients with IgG4-related disease.
OBJECTIVE
It has been discussed whether IgG4-related disease (IgG4-RD), including autoimmune pancreatitis (AIP), is associated with malignancy; however, the issue has not been clarified.


METHODS
We analyzed 113 patients with IgG4-RD in whom malignancy was not diagnosed at the time of IgG4-RD onset and the follow-up period was longer than six months. A total of 95 patients had AIP. The mean follow-up period was 73 months. The incidence of the observed malignancies was compared with the expected incidence in an age- and sex-matched general Japanese population based on the Vital Statistics of Japan.


RESULTS
There were 15 malignancies (lung cancer in five patients, pancreatic cancer in two patients, gastric cancer in two patients, bile duct cancer in one patient, renal cancer in one patient, breast cancer in one patient, tongue cancer in one patient, malignant melanoma in one patient and acute myeloid leukemia in one patient) in 14 patients during the follow-up period. The calculated standardized incidence rate of the total malignancies was not significant, that is, 1.04 (95% CI 0.57-1.75).


CONCLUSIONS
The incidence of total malignancies in IgG4-RD patients is similar to that observed in the general population. At present, it is reasonable to conclude that IgG4-RD is not associated with an increased incidence of total malignancies.
Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Japan.
Kenji
K
Hirano
Minoru
M
Tada
Naoki
N
Sasahira
Hiroyuki
H
Isayama
Suguru
S
Mizuno
Kaoru
K
Takagi
Takeo
T
Watanabe
Tomotaka
T
Saito
Shuhei
S
Kawahata
Rie
R
Uchino
Tsuyoshi
T
Hamada
Koji
K
Miyabayashi
Dai
D
Mohri
Takashi
T
Sasaki
Hirofumi
H
Kogure
Natsuyo
N
Yamamoto
Yousuke
Y
Nakai
Haruhiko
H
Yoshida
Yukiko
Y
Ito
Dai
D
Akiyama
Nobuo
N
Toda
Toshihiko
T
Arizumi
Hiroshi
H
Yagioka
Naminatsu
N
Takahara
Saburo
S
Matsubara
Yoko
Y
Yashima
Kazuhiko
K
Koike
D000368:Aged; D001327:Autoimmune Diseases / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D011446:Prospective Studies
D007074:Immunoglobulin G