Effects of an orabase formulation with ethanolic extract of Malva sylvestris L. in oral wound healing in rats.
Malva sylvestris L. is widely used in medicine for treatment of inflammatory processes. The plant has anti-inflammatory properties due to substances such as mucilage, flavonoids, and tannins. A mouthwash with leaves from the plant can be used for the treatment of wounds in the oral mucosa. The aim of this study was to assess the wound healing effect of Malva sylvestris L. on a palate mucosa wound in rats. After intraperitoneal anesthesia, a 4-mm-diameter excisional wound was made in the center of the palatal mucosa of 136 rats, using a punch-out biopsy tool. Eight animals were used as baseline wound. The remaining rats were divided into four groups: CO, control; OB, orabase vehicle; CX, 2% chlorhexidine; and MA, 20% Malva in orabase. At 24 h postoperatively, the animals were immobilized without anesthetic to apply 25 mg of each substance twice a day, totaling 50 mg daily. The wound areas were measured photographically and the reepithelialization rates were determined histologically (%) after 0, 3, 7, 15, and 21 days. The data were analyzed by ANOVA and Tukey post hoc test. Similar healing pattern was observed among the groups (P>.05; ANOVA). According to the methodology, Malva sylvestris L. extract had no effect on wound healing in the palatal mucosa of rats.
1 Department of Dentistry, School of Dentistry, Ponta Grossa State University , Ponta Grossa, Brazil .
Ana Cristina
AC
Kovalik
Paula
P
Bisetto
Márcia Thaís
MT
Pochapski
Eduardo Baulm
EB
Campagnoli
Gibson Luiz
GL
Pilatti
Fábio André
FA
Santos
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000431:Ethanol; D005419:Flavonoids / Q000008:administration & dosage; D008297:Male; D028501:Malva / Q000737:chemistry*; D009061:Mouth Mucosa / Q000293:injuries* / Q000473:pathology; D010159:Palate; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013634:Tannins / Q000008:administration & dosage; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D010936:Plant Extracts; D013634:Tannins; D000431:Ethanol; C056627:Orabase; D002266:Carboxymethylcellulose Sodium
herbal medicine; medicinal food; mucosa; oral ulcer; palate; phytotherapy; rat; wound healing