Randomized clinical efficacy of superficial peeling with 85% lactic acid versus 70% glycolic acid.
BACKGROUND
Peeling is a procedure which aims to accelerate the process of skin exfoliation.


OBJECTIVE
Development of formulations containing lactic acid at 85% or glycolic acid at 70% and the evaluation of these formulations on clinical efficacy in reduction of fine wrinkles.


METHODS
Preliminary stability tests were carried out and an in vivo study was performed with three groups with 9 representatives each. One was the control group, which used only sunscreen; another one used lactic acid+sunscreen, and the last group used acid glycolic+sunscreen. Clinical efficacy was assessed with a CCD color microscope, through the digitization of images before and after treatment. The applications were carried out by a dermatologist, once a mont h every 30 days, during 3 months. The area with wrinkles was calculated by planimetry point counting, in accordance with Mandarin-de-Lacerda.


RESULTS
The formulations were stable in the visual and Ph evaluation. There was no improvement in the control group; for lactic acid, there was significant improvement after the second peeling application on the outer lateral area of the right eye and after the third application on the outer lateral area of the left eye. For the glycolic acid group, there was significant improvement in the outer lateral area of the left eye after the first application, and of the right eye region, after three applications. The formulations used must be kept under refrigeration and should be manipulated every 30 days.


CONCLUSIONS
Both peelings were effective in reducing fine wrinkles of the outer lateral eye area after three applications (p ≤ 0.05%). It was observed that peeling efficacy in the external-lateral region of one eye might be different compared with that in skin of the external-lateral region of the other eye, relative to the speed of skin improvement.
Health Sciences College, Methodist University of Piracicaba, PiracicabaSP, Brazil, MSc, Health Sciences College, Methodist University of Piracicaba - Piracicaba (SP), Brazil.
Paula Souza
PS
Prestes
Dermatologist, Private Dermatology Office - Piracicaba (SP), Brazil.
Márcia Motta Maia de
MM
Oliveira
Institute of Environmental Chemistry and Pharmaceutical Sciences, Federal University of São Paulo, São PauloSP, Brazil, Doctor, Institute of Environmental Chemistry and Pharmaceutical Sciences, Federal University of São Paulo (UNIFESP). Post-Graduate in Translational Medicine - Federal University of São Paulo (UNIFESP), São Paulo (SP), Brazil.
Gislaine Ricci
GR
Leonardi
D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D002615:Chemexfoliation / Q000379:methods*; D005123:Eye; D005260:Female; D006016:Glycolates / Q000008:administration & dosage*; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage*; D019344:Lactic Acid / Q000008:administration & dosage*; D008875:Middle Aged; D015203:Reproducibility of Results; D012867:Skin / Q000187:drug effects; D015595:Skin Aging / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome
D006016:Glycolates; D007641:Keratolytic Agents; C031149:glycolic acid; D019344:Lactic Acid