Polymorphic distribution and forensic effectiveness study of eight miniSTR in Chinese Uyghur ethnic group.
We obtained the allelic frequencies and forensic efficiency data for eight mini short tandem repeat loci including Penta E, D12S391, D6S1043, D2S1338, D19S433, CSF1PO, Penta D and D19S253 loci from a sample of 128 unrelated Uyghur individuals from China. The amplification products of the eight STR loci are <240 bp in size. A total of 94 alleles were observed and the corresponding allelic frequencies ranged from 0.0039 to 0.3438 in the present study. Observed genotype distributions for each locus do not show deviations from Hardy-Weinberg equilibrium expectations. The combined power of discrimination, combined power of exclusion and combined matching probability of the eight STR loci equaled to 0.999999999963373, 0.9997770 and 3.6627 × 10(-11), respectively. Because of the small fragment length of PCR products and the high degree of polymorphisms, the eight STR loci are highly beneficial for the forensic analysis of degraded DNA samples which are commonly observed in forensic cases. The STR data of the Uyghur group were compared with the previously published population STR data of other groups from different ethnic or areas, and significant differences were observed among these groups at some loci.
Medical Genetic Institute of Henan Province, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, 450003, People's Republic of China.
Hong-Dan
HD
Wang
Ji-Gang
JG
Ruan
Chun-Mei
CM
Shen
Yu-Dang
YD
Zhang
Wen-Juan
WJ
Liu
Hao-Tian
HT
Meng
Xin-Yuan
XY
Yang
Jiang-Wei
JW
Yan
Shi-Xiu
SX
Liao
Shuan-Liang
SL
Fan
Xiao-di
XD
Jia
Xing
X
Wei
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002681:China; D005006:Ethnicity / Q000235:genetics*; D053803:Forensic Genetics; D005787:Gene Frequency; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic