Sorbicatechols A and B, antiviral sorbicillinoids from the marine-derived fungus Penicillium chrysogenum PJX-17.
Two novel sorbicillinoids combining a bicyclo[2.2.2]octane with a 2-methoxyphenol moiety, named sorbicatechols A (1) and B (2), were isolated from the culture of the marine sediment-derived fungus Penicillium chrysogenum PJX-17, together with the known protocatechuic acid methyl ester and caffeic acid methyl ester (3). Their structures, including absolute configurations, were assigned by analysis of NMR, MS data, and TDDFT ECD calculations. Compounds 1 and 2 exhibited activities against influenza virus A (H1N1), with IC50 values of 85 and 113 μ M, respectively.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
Jixing
J
Peng
Xiaomin
X
Zhang
Lin
L
Du
Wei
W
Wang
Tianjiao
T
Zhu
Qianqun
Q
Gu
Dehai
D
Li
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D010408:Penicillium chrysogenum / Q000737:chemistry*; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000998:Antiviral Agents; D061065:Polyketides; C000590077:sorbicatechol A; C000590078:sorbicatechol B