[Mesothelial proliferation in rectal cancer].
In an epiphrenic lymph node of a 55 years old female patient who underwent surgical resection of a rectal adenocarcinoma epitheloid proliferations with papillary and solid growth pattern were seen additional to a metastasis of the carcinoma. Adjacent vessels contained similar infiltrates. Immunohistochemically a co-expression of pan-keratin, calretinin and WT1 was seen, suggestive for a diagnosis of a metastasis of a malignant mesothelioma. However, radiologic examination yielded no morphologic correlate to this suspicion. Further immunohistochemical work-up showed positivity for desmin, negativity for EMA, GLUT1, p53 and a low ki67-fraction of 2-3 %. Therefore, a final diagnosis of benign mesothelial proliferations disseminated into the lymph node and the adjacent vessels was made.
Abteilung Allgemeine Pathologie und Pathologische Anatomie, Institut für Pathologie und Neuropathologie, Eberhard-Karls-Universität Tübingen, Liebermeisterstr. 8, 72076, Tübingen, Deutschland, patrick.adam@med.uni-tuebingen.de.
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Adam
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Schraml
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Sipos
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D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology*; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology* / Q000601:surgery; D012007:Rectum / Q000473:pathology; D036542:Tomography, Spiral Computed
D014408:Biomarkers, Tumor