SLC30A8 rs13266634 polymorphism is related to a favorable cardiometabolic lipid profile in HIV/hepatitis C virus-coinfected patients.
OBJECTIVE
To analyze the relationship of SLC30A8 rs13266634 polymorphism with insulin resistance and dyslipidemia in HIV/hepatitis C virus (HCV)-coinfected patients.


METHODS
Cross-sectional study in 260 HIV/HVC-coinfected patients.


METHODS
SLC30A8 polymorphisms were genotyped by GoldenGate assay. Genetic data were analyzed under the dominant inheritance model (CT/TT versus CC). Cholesterol, triglycerides, high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), LDL-C/HDL-C, atherogenic index, and homeostatic model assessment of insulin resistance (HOMA-IR) values were assayed for each genotype.


RESULTS
rs13266634 CT/TT carriers had higher serum values of HDL-C (P = 0.014) and lower values of LDL-C/HDL-C (P = 0.036) and atherogenic index (P = 0.011) than CC carriers. Additionally, rs13266634 CT/TT carriers had lower percentage of HDL 35 mg/dl or less (P = 0.050) and higher percentage of LDL/HDL at least 3 (P = 0.091) and atherogenic index at least 3.5 (P = 0.003) than CC carriers. When adjusted regression analysis was performed, rs13266634 CT/TT genotype was associated with high serum values of HDL-C [arithmetic mean ratio (AMR) = 1.10 (95% confidence interval, CI = 1.03-1.19) P = 0.006], and low values of LDL-C/HDL-C [AMR = 0.88 (95% CI = 0.79-0.99) P = 0.045] and atherogenic index [AMR = 0.89 (95% CI = 0.81-0.98) P = 0.024]. For categorical outcomes, rs13266634 CT/TT carriers had lower significant likelihood of having atherogenic index at least 3.5 [odds ratio = 0.47 (95% CI = 0.26-0.83) P = 0.009], and very close to significance for LDL-C/HDL-C at least 3 [odds ratio = 0.52 (95% CI = 0.27-1.02) P = 0.056], supporting the protective effect of the CT/TT genotypes. No significant relationship was observed between rs13266634 and HOMA-IR values.


CONCLUSIONS
rs13266634 CT/TT genotype was associated to higher levels of HDL-C and lower values of cardiovascular risk indices (LDL-C/HDL-C and atherogenic index), but there was a lack of association with HOMA-IR values. Thus, rs13266634 polymorphism might play a significant role in lipid metabolism and cardiovascular risk in HIV/HCV-coinfected patients.
aUnidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda bServicio de Medicina Interna cUnidad de Enfermedades Infecciosas/VIH, Hospital General Universitario 'Gregorio Marañón' dInstituto de Investigación Sanitaria Gregorio Marañón (IiSGM) eFundación para la Investigación Biomédica, Hospital General Universitario 'Gregorio Marañón', Madrid, Spain.
Daniel
D
Pineda-Tenor
Dariela
D
Micheloud
Juan
J
Berenguer
María A
MA
Jiménez-Sousa
Amanda
A
Fernández-Rodríguez
Pilar
P
García-Broncano
María
M
Guzmán-Fulgencio
Cristina
C
Diez
José M
JM
Bellón
Ana
A
Carrero
Teresa
T
Aldámiz-Echevarria
Mónica
M
García-Álvarez
Salvador
S
Resino
D000328:Adult; D027682:Cation Transport Proteins / Q000235:genetics*; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D060005:Genotyping Techniques; D015658:HIV Infections / Q000150:complications* / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000473:pathology; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008055:Lipids / Q000097:blood*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D000075703:Zinc Transporter 8
D027682:Cation Transport Proteins; D008055:Lipids; C492522:SLC30A8 protein, human; D000075703:Zinc Transporter 8