Association between helicobacter pylori infection and body mass index, before and after eradication of infection in hemodialysis batients.
BACKGROUND
In dialysis patients, chronic infections have been associated with cachexia and anorexia.


OBJECTIVE
This study was carried out to determine the association between Helicobacter pylori (HP) infection and body mass index (BMI) in hemodialysis (HD) patients.


METHODS
Ninety eight patients were divided into two groups of negative (group 1) and positive (group 2), for HP. BMI of all patients was measured at the beginning and in group2 after six months following eradication of HP. Before dialysis, various paraclinical parameters were checked at the same intervals.


RESULTS
Fifty-nine patients were enrolled in group 1 and 39 patients in group 2. The means of BMI in groups 1 and 2 were 23.4±3.7 and 25.8±4.4kg/m², respectively. Prior to the study, there was no significant difference for BMI, duration of HD and paraclinic data between two groups. Group 2 took anti HP therapy and eradication occurred in 30 of them. In this group six months after eradication of HP, the BMI was significantly decreased from 25.02±4.4 to 24.4±4.0 kg/m² (P = 0.001). Also six months following the eradication of HP, the mean of serum albumin level was significantly declined from 4.2 to 3.7 g/L (P<0.001). There was also significant decrease in cholesterol (P=0.001), blood urea nitrogen (P=0.005) and calcium (P=0.02). However, significant increase in hemoglobin level was also seen (P=0.03).


CONCLUSIONS
The results of this study show that eradication of HP has an impact on BMI. The results need to be investigated with larger cases.
Departments of Nephrology , Imam Hossein Hospital , Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mojgan
M
Jalalzadeh
Department of Nephrology. Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Hassan
MH
Ghadiani
Department of Social Medicine , Zanjan University of Medical Sciences, Zanjan, Iran.
Nouraddin
N
Mousavinasab
Body Mass Index; H. pylori infection; Hemodialysis