Composite scaffolds of nano calcium deficient hydroxyapatite/multi-(amino acid) copolymer for bone tissue regeneration.
In this study, nano calcium deficient hydroxyapatite (n-DA)/multi-(amino acid) copolymer composite scaffolds were prepared by injection molding foaming method using calcium sulphate dihydrate as a foaming agent. The composite scaffolds showed well interconnected macropores with the pore size of ranging from 100 to 600 μm, porosity of 81 % and compressive strength of 12 MPa, and the compressive strength obviously affected by the porosity. The composite scaffolds could be slowly degraded in phosphate buffered solution (PBS), which lost its initial weight of 61 w % after immersion into PBS for 12 weeks, and the porosity significantly affected the degradability of the scaffolds. Moreover, it was found that the composite scaffolds could promote the MG-63 cells growth and proliferation, and enhance its alkaline phosphatase activity. The implantation of the scaffolds into the femoral bone of rabbits confirmed that the composite scaffolds were biocompatibitive, degradable, and osteoconductive in vivo.
College of Physical Science and Technology, Sichuan University, Chengdu, 610041, China.
Hong
H
Li
Lili
L
Yang
Xieping
X
Dong
Yifei
Y
Gu
Guoyu
G
Lv
Yonggang
Y
Yan
D000596:Amino Acids / Q000737:chemistry*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000138:chemical synthesis; D002118:Calcium / Q000737:chemistry; D002460:Cell Line; D019245:Compressive Strength; D017886:Durapatite / Q000737:chemistry*; D019544:Equipment Failure Analysis; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006801:Humans; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology*; D011108:Polymers / Q000138:chemical synthesis; D016062:Porosity; D011474:Prosthesis Design; D054457:Tissue Scaffolds
D000596:Amino Acids; D018786:Bone Substitutes; D011108:Polymers; D017886:Durapatite; D002118:Calcium