[Propensity score analysis of liver and kidney function changes when shenmai is parenterally administered over extended period].
Since parenterally administered Shenmai directly enters the bloodstream, avoiding gastrointestinal absorption, there are concerns as to its toxicity on the liver and kidneys. Previously, the risk of toxicity to the liver and kidneys through overdose has been discussed. This paper investigates changes in liver and kidney functions as indicated by ALT, AST, Cr and Bun, obtained from hospital information system (HIS) data, when it is administered over a longer than the recommended period of 14 days. Methods applied include: column joint analysis, logistic regression, propensity score and propensity score weighting. Results indicate that a longer course of administration does not have a significant effect on the function of liver and kidneys. However, continued monitoring of the toxicity to the liver and kidneys is a long-term and important issue; further exploration through toxicology experiments and prospective clinical research is required.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. wanglianxin_tcm@126.com
Lian-Xin
LX
Wang
Renmin University of China, Beijing 100872, China.
Hao
H
Cheng
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yan-Ming
YM
Xie
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Wei
W
Yang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000378:metabolism; D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006751:Hospital Information Systems / Q000706:statistics & numerical data; D006801:Humans; D007263:Infusions, Parenteral; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D064792:Pragmatic Clinical Trials as Topic; D057216:Propensity Score; D011446:Prospective Studies; D014508:Urea / Q000097:blood; D055815:Young Adult
D004365:Drugs, Chinese Herbal; D014508:Urea; D000410:Alanine Transaminase