Recent advances and new strategies in the NMR-based identification of natural products.
Nature comprises an untapped pool of unique compounds with high structural uniqueness and exceptional properties. At the core of natural products (NPs) discovery is the identification procedure and NMR remains the most efficient method. Technical improvements such as miniaturized and crycogenic NMR probes along with hyphenation capabilities and computational support are at the center of evolution. Concepts such as dereplication and metabolomics are increasingly adopted in NPs using the power of databases, currently fragmented. The introduction and utilization of these technical and computational implements could lead NPs research to more comprehensive structure identification and new holistic perspectives.
Division of Medicinal and Natural Products Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Maria
M
Halabalaki
Division of Medicinal and Natural Products Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Konstantina
K
Vougogiannopoulou
Division of Medicinal and Natural Products Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece. Electronic address: mikros@pharm.uoa.gr.
Emmanuel
E
Mikros
Division of Medicinal and Natural Products Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.
Alexios Leandros
AL
Skaltsounis
D001688:Biological Products / Q000032:analysis* / Q000737:chemistry; D002853:Chromatography, Liquid; D003201:Computers; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods*; D055432:Metabolomics
D001688:Biological Products