[Clinical analysis for 18 cases of vulvar Bowen's disease].
OBJECTIVE
To analyse the clinical and pathological characteristics, diagnosis, treatment and prognosis of vulvar Bowen's disease.


METHODS
Clinical data including pathological characteristics, diagnosis, treatment methods and follow-up of 18 cases with vulvar Bowen's disease admitted to Cancer Hospital, Chinese Academy of Medical Sciences during January 1991 to June 2011 were retrospectively analyzed.


RESULTS
The median age of the 18 patients was 37 years (range:23 to 64 years) . Sixteen patients had symptoms of vulvar itching and two patients had no symptom. Five cases were single neoplasm focus and the other 13 cases were multiple focuses. The diagnosis of vulvar Bowen's disease was according to the pathological diagnosis. Its diagnostic characteristic was giant round or ovoid cells with mono nucleolus in the whole layer of epidermis. All the patients received operation, eleven with simple vulvectomy and other seven cases with lumpectomy. The median follow-up time was 123 months (range: 5 to 197 months). Relapse was found in two cases. One patient relapsed five months postoperation and received vulvectomy. Another patient relapsed fifteen moths post-operation and received lumpectomy again. And they were follow-up for 192 months and 55 months respectively after second operation without relapse.


CONCLUSIONS
The diagnostic characteristic of vulvar Bowen's disease is giant round or ovoid cell with mono nucleolus in the whole layer of epidermis, itsdiagnosis is according to the pathological diagnosis. Operation could get very good curative effect for patients with primary vulvar Bowen's disease and even for the recurrent patients. The prognosis of vulvar Bowen's disease is good.
Department of Gynecologic Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
Guang-wen
GW
Yuan
Department of Gynecologic Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. Email:wulingying@csco.org.cn.
Ling-ying
LY
Wu
Department of Gynecologic Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
Rong
R
Zhang
Department of Gynecologic Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
Xiao-guang
XG
Li
D000328:Adult; D001706:Biopsy; D001913:Bowen's Disease / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D011379:Prognosis; D012086:Reoperation; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D014844:Vulva / Q000473:pathology / Q000601:surgery; D014846:Vulvar Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D055815:Young Adult