Are Hsp70 protein expression and genetic polymorphism implicated in multiple sclerosis inflammation?
Genetic and environmental factors contribute to disease Multiple Sclerosis (MS) susceptibility, the most prevalent neurological pathology affecting young individuals in Western countries. We focused our attention on HSP70-2, an inducible chaperon induced under stress conditions. Genotype analysis of HSP70-2 (+1267 A/G) polymorphism revealed a significant association between the minor allele G and presence of MS (OR:1.31, 95% CI: 1.02-1.69, P = 0.039). In addition, Hsp70-2 protein content in vitro from PBMC was significantly lower in MS patients with GG genotype compared to AA genotype, indicating an implication of the G allele of HSP70-2 gene polymorphism in the development of MS.
Inter-department Multiple Sclerosis Research Centre, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy. Electronic address: chiara.boiocchi@unipv.it.
Chiara
C
Boiocchi
Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy.
Cecilia
C
Osera
Section of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Maria Cristina
MC
Monti
Section of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Ottavia Eleonora
OE
Ferraro
Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy.
Stefano
S
Govoni
Laboratory of Immunogenetics, Department of Biology & Biotechnology "L. Spallanzani", University of Pavia, Pavia, Italy.
Mariaclara
M
Cuccia
Section of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Cristina
C
Montomoli
Department of Drug Sciences, Section of Pharmacology, University of Pavia, Pavia, Italy.
Alessia
A
Pascale
Inter-department Multiple Sclerosis Research Centre, C. Mondino National Institute of Neurology Foundation, IRCCS, Pavia, Italy.
Roberto
R
Bergamaschi
D000328:Adult; D015153:Blotting, Western; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000378:metabolism; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics* / Q000378:metabolism*; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
D018840:HSP70 Heat-Shock Proteins; C525621:HSPA1B protein, human
HSP70-2 (+1267 A/G) polymorphism; Multiple Sclerosis; Neuroinflammation