Genes and genetic variations involved in the development of hypertension: focusing on a Greek patient cohort.
BACKGROUND
Essential hypertension (HTN) is a multifactorial disease involving environmental, genetic and other factors. Over the past years, genetic studies of essential HTN have increased dramatically but the molecular mechanisms involved are still unknown. As part of a research program coordinated by Boston university (USA), we studied the role of various genes and single nucleotide polymorphisms (SNPs) in the inheritance or the onset of HTN in African-American, Caucasian-American and Greek families.


METHODS
Among 128 Greek families with a history of HTN, we studied 1474 people. Of the total examined, 273 men and 286 women were hypertensive. Based on 410 DNA samples from the hypertensive subjects, different SNPs were examined. An overall meta-analysis of the results from the Greek families, as well as a comparison with the 2 other groups (African-Americans and Caucasian-Americans), was performed.


RESULTS
We report SNPs that are associated with the inheritance of HTN and are located either at the promoters of N-methyltransferase and catalase genes, or within the coding region of NEDD4L ubiquitin ligase gene, or SNPs in mitochondrial DNA of hypertensive probands. Furthermore, we clarified the role of hereditary predisposition in the development of HTN, showing that the presence of maternal HTN was significantly higher in African-Americans and Greeks compared to Caucasian-Americans (81.7%, 84.8%, and 65%), while the paternal HTN showed no such difference (50%, 48.3% and 44.9%), respectively.


CONCLUSIONS
Although genetic factors that were correlated with HTN were identified, it was not possible to identify a single gene that should be targeted for the treatment of HTN. Nevertheless, the important role of the maternal hereditary predisposition to HTN in the Greek patients and the responsible genetic factors involved should be further examined.
Department of Cardiology, Asklepeion General Hospital, Voula, Greece.
Nikolaos
N
Kouremenos
Ioanna V
IV
Zacharopoulou
Helen
H
Triantafyllidi
Georgios V
GV
Zacharopoulos
Cristian
C
Mornos
Gerasimos
G
Filippatos
John
J
Lekakis
Dimitrios
D
Kremastinos
Athanasios I
AI
Manolis
Haralambos
H
Gavras
D000075222:Essential Hypertension; D005260:Female; D014644:Genetic Variation; D006115:Greece; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide