Association between endotoxin activity and acute kidney injury in cardiac patients undergoing cardiopulmonary bypass.
OBJECTIVE
Cardiopulmonary bypass (CPB) has been thought to promote endotoxin translocation from the gut. Increased endotoxin activity (EA) has been related to a worsening of organ dysfunction, particularly acute kidney injury (AKI). This study aims to determine if CPB could influence EA after cardiac surgery, and if EA variations are associated with renal dysfunction following CPB.


METHODS
This was an observational study of patients subjected to complex cardiac surgery, likely to last for >120 min. Blood samples were obtained before, during and after CPB for EA analysis. AKI occurrence defined by the Acute Kidney Injury Network criteria was evaluated.


RESULTS
Eighteen patients were enrolled. EA significantly increased after 12 h following CPB. Variations of EA from baseline were significantly associated with variations of creatinine, i.e. AKI.


CONCLUSIONS
Complex cardiac surgery requiring long CPB promotes EA increases that could be associated with variations of serum creatinine and AKI occurrence.
U.O.C. Cardioanesthesia and Cardio-Intensive Care, San Carlo Hospital, Potenza, Italy.
Gianluca
G
Paternoster
Gianni
G
Rubino
Antonio
A
Balducci
Rosmunda
R
Maiorano
Nicola
N
Brienza
D058186:Acute Kidney Injury / Q000097:blood*; D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D004731:Endotoxins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013903:Thoracic Surgery
D004731:Endotoxins; D003404:Creatinine