The effect of high and low frequency cortical stimulation with a fixed or a poisson distributed interpulse interval on cortical excitability in rats.
Neurostimulation is a promising treatment for refractory epilepsy. We studied the effect of cortical stimulation with different parameters in the rat motor cortex stimulation model. High intensity simulation (threshold for motor response--100 μA), high frequency (130 Hz) stimulation during 1 h decreased cortical excitability, irrespective of the interpulse interval used (fixed or Poisson distributed). Low intensity (10 μA) and/or low frequency (5 Hz) stimulation had no effect. Cortical stimulation appears promising for the treatment of neocortical epilepsy if frequency and intensity are high enough.
Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.
Ine
I
Buffel
Alfred
A
Meurs
Robrecht
R
Raedt
Veerle
V
de Herdt
Leen
L
Decorte
Laurence
L
Bertier
Jean
J
Delbeke
Wytse
W
Wadman
Kristl
K
Vonck
Paul
P
Boon
D000818:Animals; D046690:Deep Brain Stimulation; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D019054:Evoked Potentials, Motor; D008297:Male; D009044:Motor Cortex / Q000502:physiology*; D016012:Poisson Distribution; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors