Translational pain biomarkers in the early development of new neurotherapeutics for pain management.
Translation of the analgesic efficacy of investigational neurotherapeutics from pre-clinical pain models into clinical trial phases is associated with a high risk of failure. Application of human pain biomarkers in early stages of clinical trials can potentially enhance the rate of successful translation, which would eventually reduce both length and costs of drug development after the pre-clinical stage. Human pain biomarkers are based on the standardized activation of pain pathways followed by the assessment of ongoing and paroxysmal pain, plus evoked responses which can be applied to healthy individuals and patients prior to and after pharmacological interventions. This review discusses the rationality and feasibility of advanced human pain biomarkers in early phases of drug development for pain management which is still an unmet medical need.
Department of Health Science and Technology, Center for Sensory-Motor Interaction (SMI), Aalborg University, Fredrik Bajers Vej 7D-3, 9220 Aalborg East, Denmark.
Lars
L
Arendt-Nielsen
Thomas Arendt
TA
Nielsen
Parisa
P
Gazerani
D000700:Analgesics; D015415:Biomarkers; D055808:Drug Discovery; D006801:Humans; D059408:Pain Management / Q000379:methods*
D000700:Analgesics; D015415:Biomarkers