Multifunctional theranostic gold nanoparticles for targeted CT imaging and photothermal therapy.
Gold nanoparticles have emerged as some of the most extensively utilized nanoplatforms for the diagnosis, imaging, monitoring and treatment of malignant diseases. In particular, in computed tomography (CT) imaging and in therapy (PTT), the exploitation of the various, advantageous properties of gold nanoparticles have resulted in numerous advances in each of these fields. The purpose of this review is to assess the status of gold-nanoparticle mediated CT and PTT, highlight several promising outcomes and motivate the combination of these two functionalities in the same nanoparticle platform. The given examples of research based advances and the encouraging results of in vitro and in vivo studies provide much excitement and promise for future theranostic (therapy + diagnostic) clinical applications, as well as for image-guided therapy and/or surgery, and their monitoring.
Department of Chemistry, University of Michigan, Ann Arbor, MI, USA, 48109.
Taeyjuana
T
Curry
Raoul
R
Kopelman
Malka
M
Shilo
Rachela
R
Popovtzer
D006046:Gold / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053768:Metal Nanoparticles; D009369:Neoplasms / Q000175:diagnosis / Q000473:pathology; D010789:Phototherapy / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*
D006046:Gold
computed tomography (CT); gold nanoparticles; photothermal therapy (PTT)