Immunoreactivity for Ca 125 and INI 1 loss of expression are useful markers in the diagnosis of vulvar proximal-type epithelioid sarcomas: report of two cases.
Epithelioid sarcomas (ES) are rare soft tissue tumours of obscure histogenesis. Diagnosis is often difficult as specific morphological and immunohistochemical patterns do not exist. Two distinct clinico-pathological entities have been identified: the classic or distal type and the proximal type. Recently, immunohistochemical detection of Ca 125 was described in ES, as well as loss of INI 1 expression. The authors describe in this paper the morphological and immunohistochemical features of two cases of proximal ES of the vulva. Immunoreactivity for Ca 125 and loss of INI 1 expression were present in both cases. These results confirm previous observations in Asian reports showing that these markers can be used as immunohistochemical markers for the diagnostic assessment of ES.
Department of Surgical, Microsurgical, and Medical Sciences, University of Sassari, Sassari, Italy.
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Cossu
Department of Surgical, Microsurgical, and Medical Sciences, University of Sassari, Sassari, Italy.
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Paliogiannis
Department of Surgical, Microsurgical, and Medical Sciences, Gynecologic and Obstetric Clinic University of Sassari, Sassari, Italy.
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Capobianco
lnstitute of Biomolecular Chemistry, Cancer Genetics Unit, C.N.R., Sarsari, Sassari, Italy.
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Sini
Department of Surgical, Microsurgical, and Medical Sciences, Gynecologic and Obstetric Clinic University of Sassari, Sassari, Italy.
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Dessole
Department of Surgical, Microsurgical, and Medical Sciences, Gynecologic and Obstetric Clinic University of Sassari, Sassari, Italy.
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Dessole
lnstitute of Biomolecular Chemistry, Cancer Genetics Unit, C.N.R., Sarsari, Sassari, Italy.
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Palmieri
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D018394:CA-125 Antigen / Q000032:analysis* / Q000276:immunology; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D000071796:SMARCB1 Protein; D012509:Sarcoma / Q000175:diagnosis*; D014157:Transcription Factors / Q000235:genetics*; D014846:Vulvar Neoplasms / Q000175:diagnosis*
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; D014157:Transcription Factors