Genetic modifiers of obesity and bariatric surgery outcomes.
Obesity is a highly heritable trait. While acute and chronic changes in body weight or obesity-related comorbidities are heavily influenced by environmental factors, there are still strong genomic modifiers that help account for inter-subject variability in baseline traits and in response to interventions. This review is intended to provide an up-to-date overview of our current understanding of genetic influences on obesity, with emphasis on genetic modifiers of baseline traits and responses to intervention. We begin by reviewing how genetic variants can influence obesity. We then examine genetic modifiers of weight loss via different intervention strategies, focusing on known and potential modifiers of surgical weight loss outcomes. We will pay particular attention to the effects of patient age on outcomes, addressing the risks and benefits of adopting early intervention strategies. Finally, we will discuss how the field of bariatric surgery can leverage knowledge of genetic modifiers to adopt a personalized medicine approach for optimal outcomes across this widespread and diverse patient population.
Research Center for Genetic Medicine, Children's National Medical Center, 111 Michigan Ave NW, Washington, DC 20010.
Samantha
S
Sevilla
Research Center for Genetic Medicine, Children's National Medical Center, 111 Michigan Ave NW, Washington, DC 20010. Electronic address: mhubal@childrensnational.org.
Monica J
MJ
Hubal
D050110:Bariatric Surgery / Q000379:methods; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D009765:Obesity / Q000235:genetics* / Q000601:surgery*; D016896:Treatment Outcome; D015431:Weight Loss / Q000235:genetics
D005819:Genetic Markers
Bariatric surgery; Genetic modifiers; Obesity; Personalized medicine