Synthesis of deuterium-labelled fluorobenzoic acids to be used as internal standards in isotope dilution mass spectrometry.
A method for the deuterium labelling of fluorobenzoic acids (FBAs) via acidic H/D exchange of the aromatic hydrogen atoms in concentrated D2SO4 is described. The synthesis is shown to be easy, fast, low-priced and without the use of catalysts or further purification. The use of at least double-deuterated FBAs as internal standards in organic isotope dilution mass spectrometry allows the determination of FBAs in complex matrices with highest possible accuracy in combination with a simplified analytical evaluation.
a Chemistry Department , University of Marburg , Marburg , Germany.
Karsten
K
Müller
Andreas
A
Seubert
D060326:Chemistry Techniques, Synthetic; D003903:Deuterium / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods* / Q000592:standards*
D006845:Hydrocarbons, Fluorinated; D003903:Deuterium