Recent developments in experimental animal models of Henipavirus infection.
Hendra (HeV) and Nipah (NiV) viruses (genus Henipavirus (HNV; family Paramyxoviridae) are emerging zoonotic agents that can cause severe respiratory distress and acute encephalitis in humans. Given the lack of effective therapeutics and vaccines for human use, these viruses are considered as public health concerns. Several experimental animal models of HNV infection have been developed in recent years. Here, we review the current status of four of the most promising experimental animal models (mice, hamsters, ferrets, and African green monkeys) and their suitability for modeling the clinical disease, transmission, pathogenesis, prevention, and treatment for HNV infection in humans.
Galveston National Laboratory, Departments of Pathology and Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Barry
B
Rockx
D000818:Animals; D035843:Biomedical Research / Q000639:trends; D002522:Chlorocebus aethiops; D006224:Cricetinae; D004195:Disease Models, Animal; D005289:Ferrets; D045464:Henipavirus Infections / Q000188:drug therapy / Q000473:pathology* / Q000517:prevention & control / Q000635:transmission; D051379:Mice
Henipavirus; animal model; pathogenesis