Human papillomavirus (HPV) genotypes in an Australian sample of anal cancers.
Human papillomavirus (HPV) causes most cases of anal cancers. In this study, we analyzed biopsy material from 112 patients with anal cancers in Australia for the presence of HPV DNA by the INNO LiPA HPV genotyping assay. There were 82% (92) males and 18% (20) females. The mean age at diagnosis was significantly (p = 0.006) younger for males (52.5 years) than females (66 years). HIV-infected males were diagnosed at a much earlier mean age (48.2 years) than HIV negative (56.3 years) males (p = 0.05). HPV DNA was detected in 96.4% (108) of cases. HPV type 16 was the commonest, at 75% (81) of samples and being the sole genotype detected in 61% (66). Overall, 79% (85) of cases had at least one genotype targeted by the bivalent HPV (bHPV) vaccine, 90% (97) by the quadrivalent HPV (qHPV) vaccine and 96% (104) by the nonavalent HPV (nHPV) vaccine. The qHPV vaccine, which is now offered to all secondary school students in Australia, may prevent anal cancers in Australia. However, given the mean age of onset of this condition, the vaccine is unlikely to have a significant impact for several decades. Further research is necessary to prove additional protective effects of the nHPV vaccine.
Western Sydney Sexual Health Centre, University of Sydney, Westmead Hospital, Sydney, Australia.
Richard J
RJ
Hillman
Suzanne M
SM
Garland
Manoji P W
MP
Gunathilake
Matthew
M
Stevens
Nirmala
N
Kumaradevan
Charlotte
C
Lemech
Robyn L
RL
Ward
Alan
A
Meagher
Leo
L
McHugh
Fengyi
F
Jin
Susan
S
Carroll
David
D
Goldstein
Andrew E
AE
Grulich
Sepehr N
SN
Tabrizi
D000328:Adult; D000367:Age Factors; D000368:Aged; D001005:Anus Neoplasms / Q000453:epidemiology* / Q000821:virology*; D001315:Australia; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005814:Genes, Viral; D005838:Genotype; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology*; D017422:Sequence Analysis, DNA; D012737:Sex Factors
D004279:DNA, Viral
Australia; HPV; anal cancer; prevalence; vaccination