[The drosophila hematopoietic niche].
Stem cells are required for both tissue renewal and repair in response to injury. The maintenance and function of stem cells is controlled by their specific cellular microenvironment called "niche". Hematopoietic stem cells (HSC) that give rise to all blood cell types have been extensively studied in mammals. Genetic and molecular analyses performed in mice identified several signaling pathways involved in the cellular communications between HSC and their niche. However, hematopoietic niche plasticity remains poorly understood. The discovery of a Drosophila hematopoietic niche, called PSC, established a new model to decipher the niche function in vivo. Size control of the PSC is essential to maintain hematopoietic tissue homeostasis and a molecular cascade controlling the PSC cell number has been characterized. Novel parallels between Drosophila and mammalian hematopoietic niches open new perspectives for studies of HSC biology in human.
Centre de biologie du développement, UMR 5547 CNRS/UPS, Toulouse III, 118, route de Narbonne, 31062 Toulouse Cedex 9, France.
Ismaël
I
Morin-Poulard
Centre de biologie du développement, UMR 5547 CNRS/UPS, Toulouse III, 118, route de Narbonne, 31062 Toulouse Cedex 9, France.
Isabelle
I
Louradour
Centre de biologie du développement, UMR 5547 CNRS/UPS, Toulouse III, 118, route de Narbonne, 31062 Toulouse Cedex 9, France.
Nathalie
N
Vanzo
Centre de biologie du développement, UMR 5547 CNRS/UPS, Toulouse III, 118, route de Narbonne, 31062 Toulouse Cedex 9, France.
Michèle
M
Crozatier
D000818:Animals; D004330:Drosophila / Q000166:cytology / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008322:Mammals; D051379:Mice; D008954:Models, Biological; D055153:Stem Cell Niche / Q000502:physiology*