Toward lead-oriented synthesis: one-pot version of Castagnoli condensation with nonactivated alicyclic anhydrides.
One-pot variation of Castagnoli condensation, that is, reaction of cyclic anhydrides, amines, and aldehydes, has been developed as a combinatorial approach to 1,2-disubstituted 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids, as well as their benzo-analogues. Utility of the method to multigram preparation of building blocks and synthetic intermediates was also demonstrated. The final products are obtained in high yields and diastereoselectivity. The method fits well in the concept of lead-oriented synthesis; in particular, it can be used for the design of lead-like compound libraries, even if the strictest cut-offs are applied to the physicochemical properties of their members.
The Institute of High Technologies, Taras Shevchenko National University of Kyiv , Glushkov Street 4, Kyiv 03187, Ukraine.
Sergey V
SV
Ryabukhin
Dmitriy M
DM
Panov
Dmitry S
DS
Granat
Eugeniy N
EN
Ostapchuk
Dmitriy V
DV
Kryvoruchko
Oleksandr O
OO
Grygorenko
D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000812:Anhydrides / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006840:Hydrocarbons, Alicyclic / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D000588:Amines; D000812:Anhydrides; D006840:Hydrocarbons, Alicyclic