Anaerobic metabolism associated with traumatic hemorrhagic shock monitored by microdialysis of muscle tissue is dependent on the levels of hemoglobin and central venous oxygen saturation: a prospective, observational study.
BACKGROUND
Traumatic hemorrhagic shock resulting in tissue hypoxia is a significant cause of morbidity and mortality in polytraumatized patients. Early identification of tissue hypoxia is possible with microdialysis. The aim of this study was to determine the correlation between a marker of tissue hypoxia (L/P; lactate to pyruvate ratio) and selected parameters of systemic oxygen delivery (Hb; hemoglobin) and oxygen extraction (ScvO2; central venous oxygen saturation). We also investigated the severity of tissue hypoxia over the course of care.


METHODS
Adult patients with traumatic hemorrhagic shock were enrolled in this prospective, observational study. Microdialysis of the peripheral muscle tissue was performed. Demographic data and timeline of care were collected. Tissue lactate, pyruvate, glycerol, glucose levels, hemoglobin, serum lactate and oxygen saturation of the central venous blood (ScvO2) levels were also measured.


RESULTS
The L/P ratio trend may react to changes in systemic hemoglobin levels with a delay of 7 to 10 hours, particularly when systemic hemoglobin levels are increased by transfusion. Decrease in tissue L/P ratio may react to increase in ScvO2 with a delay of up to 10 hours, and such a decrease may signify elimination of tissue hypoxia after transfusion. We also observed changes in the L/P trend in the 13 hours preceding a change in the hemoglobin level. Fluid administration, which is routinely used as a first-line treatment of hypovolemic shock, can cause hemodilution and decreased hemoglobin. When ScvO2 decreases, increase in L/P ratio may precede the ScvO2 trend by 10 or 11 hours. An increase in the L/P ratio is an early warning sign of insufficient tissue oxygenation and should lead to intensive observation of hemoglobin levels, ScvO2 and other hemodynamic parameters. Patients who were treated more rapidly had lower maximal L/P values and a lower degree of tissue ischemia.


CONCLUSIONS
The L/P ratio is useful to identify tissue ischemia and can estimate the effectiveness of fluid resuscitation. An increase in the L/P ratio is an early warning sign of inadequate tissue oxygenation and should lead to more detailed hemodynamic and laboratory monitoring. This information cannot usually be obtained from global markers.
Department of anesthesiology and intensive care medicine, University Hospital Ostrava, Faculty of Medicine Universitas Ostrava, 17 listopadu, 1790 Ostrava-Poruba, Czech Republic. bursaf@seznam.cz.
Filip
F
Burša
Leopold
L
Pleva
D000293:Adolescent; D000328:Adult; D005260:Female; D005440:Fluid Therapy; D005500:Follow-Up Studies; D006439:Hemodynamics; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D007773:Lactates / Q000378:metabolism; D008297:Male; D017551:Microdialysis / Q000379:methods*; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D009104:Multiple Trauma; D018482:Muscle, Skeletal / Q000378:metabolism*; D010092:Oximetry; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology*; D011446:Prospective Studies; D012151:Resuscitation; D012771:Shock, Hemorrhagic / Q000209:etiology / Q000378:metabolism* / Q000628:therapy; D012774:Shock, Traumatic / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D055815:Young Adult
D006454:Hemoglobins; D007773:Lactates; D010100:Oxygen