[AL amyloidosis-associated factor X deficiency].
BACKGROUND
An acquired bleeding tendency is a specific symptom that can indicate an underlying disease.


METHODS
Here we describe a 69-year-old patient with an acquired bleeding tendency resulting from a factor X deficiency due to an underlying amyloid light-chain (AL) amyloidosis. Factor X deficiency in AL amyloidosis arises from a quantitative and qualitative deficiency of factor X because it binds to amyloid fibrils exposed to circulating blood.


CONCLUSIONS
Bleeding tendency is a rare complication of AL amyloidosis, often resulting from a factor X deficiency.
UMC Groningen, Groningen.
F Nanne
FN
Croles
Charles H
CH
Beerenhout
André B
AB
Mulder
Karina
K
Meijer
Marten R
MR
Nijziel
D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis; D001780:Blood Coagulation Tests; D005166:Factor V Deficiency / Q000175:diagnosis; D005171:Factor X Deficiency / Q000175:diagnosis / Q000209:etiology*; D017809:Fatal Outcome; D006333:Heart Failure / Q000175:diagnosis; D006470:Hemorrhage / Q000150:complications / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male