[Literature review of application of shenmai injection in special populations (children)].
OBJECTIVE
Analyze the characteristic features of Shenmai injections as used in pediatric clinics, to improve the specifications for use in children in order to decrease risks.


METHODS
We preformed statistical analyses on data from the CNKI and VIP databases relevant to the clinical application of Shenmai injections in children. Pediatric indications, usage and dosage, length of treatment, solubility of the drugs in mediums and adverse reactions were summarized.


RESULTS
Shenmai injection is widely used in clinical pediatrics, and is reported to show effectivenss for conditions such as viral myocarditis, pneumonia, neonatal hypoxic ischemic encephalopathy, neonatal scleroderma, diarrhea and other diseases. However, there are no specific specifications regarding usage and dosages, length of treatments, or instructions regarding solvents. Adverse reactions reported include, drug rash, heat, blushing, and chest tightness amongst others.


CONCLUSIONS
Effective measures should be adopted to standardize the clinical regulations regarding Shenmai injections for use in children, to reduce risks, and thereby raise clinical treatment standards.
First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. zxl2072@126.com
Xi-Lian
XL
Zhang
First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Rong
R
Ma
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yan-Ming
YM
Xie
First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Meng
M
Li
First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Ping
P
Rong
D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D004338:Drug Combinations; D004358:Drug Therapy; D064420:Drug-Related Side Effects and Adverse Reactions / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D007223:Infant; D007263:Infusions, Parenteral; D008297:Male
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C009252:fructus schizandrae, radix ginseng, radix ophiopogonis drug combination