Reliability of triclosan measures in repeated urine samples from Norwegian pregnant women.
Triclosan (TCS) is a synthetic antibacterial chemical that is used in personal care products and is measurable in urine. Urinary TCS has been associated with allergy in children in Norway and the United States. A reasonable degree of temporal reliability of TCS urinary concentrations has been reported among US children as well as for Puerto Rican pregnant women. We examined the reliability of TCS measures in urine among Norwegian pregnant women. TCS was measured in spot urine samples collected in gestational weeks 17, 23, and 29 from 45 women in The Norwegian Mother and Child Cohort Study (MoBa) enrolled in 2007 and 2008. Spearman's rank correlation coefficient (rs) and intraclass correlation coefficient (ICC) statistics were calculated. Fifty-six percent of the 45 women had a least one sample with a value above the method limit of detection (2.3 μg/l). The correlation coefficients were 0.61 for TCS concentrations at 17 and 23 weeks and 0.49 for concentrations at 17 and 29 weeks. For the three time points, the ICC was 0.49. The reliability of TCS concentrations in repeated urine samples from pregnant Norwegian women was reasonably good, suggesting a single urine sample can adequately represent TCS exposure during pregnancy.
1] Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Cardina, USA [2] Department of food, water and cosmetics, Norwegian Institute of Public Health, Oslo, Norway.
Randi J
RJ
Bertelsen
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Stephanie M
SM
Engel
1] Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Cardina, USA [2] Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Todd A
TA
Jusko
Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Antonia M
AM
Calafat
Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Cardina, USA.
Jane A
JA
Hoppin
Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Cardina, USA.
Stephanie J
SJ
London
Department of Genes and Environment, Norwegian Institute of Public Health, Oslo, Norway.
Merete
M
Eggesbø
Department of Childhood, Development and Cultural diversity, Norwegian Institute of Public Health, Oslo, Norway.
Heidi
H
Aase
Department of Genetics, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Pål
P
Zeiner
Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Ted
T
Reichborn-Kjennerud
Environment and Mental Health, Norwegian Institute of Public Health, Oslo, Norway.
Gun P
GP
Knudsen
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Virginia T
VT
Guidry
Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS/NIH), Research Triangle Park, North Cardina, USA.
Matthew P
MP
Longnecker
D000891:Anti-Infective Agents, Local / Q000652:urine*; D005260:Female; D006801:Humans; D009664:Norway; D011247:Pregnancy; D015203:Reproducibility of Results; D014260:Triclosan / Q000652:urine*
D000891:Anti-Infective Agents, Local; D014260:Triclosan