Rh-catalyzed oxidative C-C bond formation and C-N bond cleavage: direct access to C2-olefinated free (NH)-indoles and pyrroles.
The rhodium-catalyzed oxidative C2-olefination of indoles and pyrroles containing N-arylcarboxamide directing groups with a range of alkenes and subsequent cleavage of directing groups is described. This method provides direct and efficient access to C2-functionalized free (NH)-heterocycles.
School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea. insukim@skku.edu.
Satyasheel
S
Sharma
Sangil
S
Han
Mirim
M
Kim
Neeraj Kumar
NK
Mishra
Jihye
J
Park
Youngmi
Y
Shin
Jimin
J
Ha
Jong Hwan
JH
Kwak
Young Hoon
YH
Jung
In Su
IS
Kim
D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D022781:Hepatocytes / Q000166:cytology*; D007211:Indoles / Q000737:chemistry*; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*
D007211:Indoles; D011758:Pyrroles; D002244:Carbon; D012238:Rhodium