Novel α,α-bischolesteryl functional (co)polymers: RAFT radical polymerization synthesis and preliminary solution characterization.
Well-defined poly[pentafluorophenyl (meth)acrylate] (PPFP(M)A) homopolymers are prepared by RAFT radical polymerization mediated by a novel chain transfer agent containing two cholesteryl groups in the R-group fragment. Subsequent reaction with a series of small-molecule amines in the presence of an appropriate Michael acceptor for ω-group end-capping yields a library of novel bischolesteryl functional hydrophilic homopolymers. Two examples of statistical copolymers are also prepared including a biologically relevant sugar derivative. Specific examples of these homopolymers are examined with respect to their ability to self assemble in aqueous media-a process driven entirely by the cholesteryl end groups. In all instances evaluated, and under the preparation conditions examined, the homopolymers aggregate clearly forming polymersomes spanning an impressive size range.
Centre for Advanced Macromolecular Design (CAMD), School of Chemical Engineering, University of New South Wales, Kensington, Sydney, NSW, 2052, Australia.
Peter J
PJ
Roth
Thomas P
TP
Davis
Andrew B
AB
Lowe
D000588:Amines / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D015394:Molecular Structure; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D005464:Fluorobenzenes; D005466:Fluorocarbons
D000588:Amines; D005609:Free Radicals; D008689:Methacrylates; D011108:Polymers; D012996:Solutions; C035583:pentafluorophenylmethacrylate; D005464:Fluorobenzenes; D005466:Fluorocarbons
RAFT; cholesterol; end groups; self-assembly; vesicles