Cucurbitane-type triterpenoids from the leaves of Momordica charantia.
Phytochemical investigation of the ethanol extract from the leaves of Momordica charantia L. led to the isolation of two new (1, 2) and four known (3-6) cucurbitane-type triterpenoids. Their structures were elucidated on the basis of extensive analyses of spectroscopic data including IR, UV, MS, 1D, and 2D NMR. Also the absolute configurations of momordicines I (3) and II (4) were determined for the first time by application of the modified Mosher's method, acid hydrolysis, and GC analysis.
a Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou 510632 , China.
Yu-Bo
YB
Zhang
Huan
H
Liu
Cun-Ya
CY
Zhu
Mao-Xin
MX
Zhang
Yao-Lan
YL
Li
Bing
B
Ling
Guo-Cai
GC
Wang
D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D029777:Momordica charantia / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
D004365:Drugs, Chinese Herbal; D014315:Triterpenes