Novel pathways and products from 2-keto acids.
Since traditional chemical processes are non-renewable and environmentally unfriendly, biosynthesis is emerging as an attractive alternative for the production of advanced biofuels, chemicals, pharmaceuticals and polymers. Cost-competitive biomanufacturing requires the design of metabolic pathways that can achieve high production yields and rates. Recent advances in natural amino acid production have motivated the use of 2-ketoacid intermediates for the production of important chemicals. These 2-ketoacids undergo a wide range of efficient biochemical reactions leading to an array of industrially useful products. In this review, recently developed novel pathways based on 2-ketoacids will be described along with representative examples.
Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, MN 55455, USA.
Pooja
P
Jambunathan
Department of Chemical Engineering and Materials Science, University of Minnesota, Twin Cities, MN 55455, USA. Electronic address: kzhang@umn.edu.
Kechun
K
Zhang
D001669:Biochemical Phenomena; D056804:Biofuels; D007651:Keto Acids / Q000378:metabolism*; D053858:Metabolic Networks and Pathways
D056804:Biofuels; D007651:Keto Acids