Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives.
A series of arylpiperazine derivatives of 1,16-diphenyl-19-azahexacyclo-[14.5.1.02,15.03,8.09,14.017,21]docosa-2,3,5,7,8,9,11,13,14-nonaene-18,20,22-trione and 4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione was synthesized. The pharmacological profile of compound4at the 5-HT1Areceptor was measured by binding assay. The title compounds were tested in cell-based assay against the human immunodeficiency virus type-1. The X-ray crystallographic studies of derivatives2,6,7,11,19, and20were presented.
Department of Medical Chemistry, Faculty of Medicine, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.
Daniel
D
Szulczyk
Department of Medical Chemistry, Faculty of Medicine, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.
Anna
A
Bielenica
Faculty of Chemistry, University of Warsaw, Pasteura 1 Street, 02-093 Warsaw, Poland.
Michał A
MA
Dobrowolski
Faculty of Chemistry, University of Warsaw, Pasteura 1 Street, 02-093 Warsaw, Poland.
Lukasz
L
Dobrzycki
Department of Medical Chemistry, Faculty of Medicine, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.
Mariola
M
Krawiecka
Department of Medical Chemistry, Faculty of Medicine, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.
Bożena
B
Kuran
Department of Medical Chemistry, Faculty of Medicine, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.
Marta
M
Struga
5-HT1A receptor; Arylpiperazines; Diels–Alder reaction; X-ray crystallography