Platelet-rich fibrin has a healing effect on chemotherapy-induced mucositis in hamsters.
OBJECTIVE
The aim of this study was to evaluate the healing effect of topically applied platelet-rich fibrin (PRF) on experimental oral mucositis induced by chemotherapy in hamsters.


METHODS
Oral mucositis was induced in 93 Syrian golden hamsters by an intraperitoneal injection of 5-fluorouracil, which was followed by light scratching of the cheek pouch. The hamsters were randomly divided into a PRF group, a fibrin group, and an untreated control group. The recovery stage of oral mucositis was evaluated through daily weighing, measurements of the ulcer area, histopathologic analysis, and a myeloperoxidase activity assay.


RESULTS
The PRF group exhibited significant improvements in the size and histologic features of the ulcer and in the myeloperoxidase activity compared with the control group (P < .05).


CONCLUSIONS
The current findings suggest the consideration for future clinical trials in humans.
Graduate Student, Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. Electronic address: koichiro@med.nagoya-cu.ac.jp.
Koichiro
K
Horii
Assistant Professor, Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Takeo
T
Kanayama
Graduate Student, Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Hironori
H
Miyamoto
Division of Oral and Maxillofacial Surgery, Keiyukai Sapporo Hospital, Sapporo, Japan.
Tomoyuki
T
Kohgo
Assistant Professor, Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Tsukasa
T
Tsuchimochi
Associate Professor, Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Toshio
T
Shigetomi
Professor, Department of Oral and Maxillofacial Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Motoo
M
Yokoi
D000287:Administration, Topical; D000818:Animals; D001792:Blood Platelets; D006224:Cricetinae; D004195:Disease Models, Animal; D005337:Fibrin / Q000494:pharmacology*; D005472:Fluorouracil / Q000633:toxicity*; D008297:Male; D008647:Mesocricetus; D009195:Peroxidase / Q000032:analysis; D011897:Random Allocation; D013280:Stomatitis / Q000139:chemically induced* / Q000517:prevention & control*; D014945:Wound Healing
D005337:Fibrin; D009195:Peroxidase; D005472:Fluorouracil