Correlation of subclinical HPV infection with genital warts and cervical erosion.
OBJECTIVE
To investigate the correlation of subclinical human papillomavirus (HPV) infection (SPI) with genital warts and cervical erosion.


METHODS
The questionnaire was firstly conducted in experimental groups (genital warts + cervical erosion), and then cervical liquid-based cytology was performed, followed by colposcopy and pathological diagnosis. In the control group, cervical liquid-based cytology and pathological diagnosis were performed. Hybrid Capture 2 assay (HC2) was conducted to detect the cervical high-risk HPV DNA.


RESULTS
The positive rate of cervical SPI in experimental groups were significantly higher than control group (p < 0.01), and in the genital warts group it was significantly higher than cervical erosion group (p < 0.05). There was no significant difference of SPI positive rate for cervical erosion with different area and degree (p > 0.05). Compared to control group, the detection rates of cervical high-risk HPV DNA in the experimental groups significantly increased (p < 0.01), and the difference between vulvar condyloma and cervical erosion groups was not statistically significant (p < 0.05). The detection rate of high-risk HPV DNA in positive SPI cases was significantly higher than negative SPI cases.


CONCLUSIONS
Women with genital warts and cervical erosion are high-risk individuals for cervical cancer, and deserve a focused initial and follow-up management.
Fourth Affiliated Hospital of China Medical University, Shenyang, China. xiacaocn@126.com
X
X
Cao
First Affiliated Hospital of Dalian Medical University, Dalian, Japan.
N
N
Gao
Maternal and Child Health Hospital of Qinhuangdao City, Qinhuangdao, China.
L
L
Huang
First Affiliated Hospital of China Medical University, Shenyang, China.
J
J
Yao
D000293:Adolescent; D000328:Adult; D003218:Condylomata Acuminata / Q000150:complications*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications*; D002583:Uterine Cervical Neoplasms / Q000209:etiology*
D004279:DNA, Viral