Vasospastic angina and Ca channel blockers.
Coronary artery spasm is one of the causes of angina pectoris,acute myocardial infarction and ventricular fibrillation-related sudden death. It has been established that Ca channel blockers are protective against vasospastic angina (VSA) and treatment with Ca channel blockers provides a better prognosis of VSA. However, it is not still clarified what kinds of Ca channel blockers shows the best prognosis of VSA. We performed a meta-analysis in which 4Ca channel blockers amlodipine, nifedipine, benidipine and diltiazem were used for the treatment of VSA patients and found that among 4 Ca channel blockers, benidipine showed a statistically significant better prognostic effect on MACE than amlodipine, nifedipine or diltiazem.
Department of Cardiology, Gifu University Graduate School of Medicine, Gifu, Japan, Yanagido 1-1, Gifu, Gifu 501-1194, Japan. minatos@gifu-u.ac.jp.
Shinya
S
Minatoguchi
D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003329:Coronary Vasospasm / Q000150:complications / Q000188:drug therapy*; D004095:Dihydropyridines / Q000627:therapeutic use*; D006801:Humans; D011379:Prognosis; D012307:Risk Factors
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; C061004:benidipine