Impact of host genetics on susceptibility and resistance to Mycobacterium avium subspecies Paratuberculosis infection in domestic ruminants.
Johne's disease or Paratuberculosis has emerged as major infectious disease of animals in general and domestic livestock in particular on global basis. There have been major initiatives in developed countries for the control of this incurable malady of animals and human beings alike (inflammatory bowel disease or Crohn's disease). Disease has not received similar attention due to inherent complexities of disease, diagnosis and control, in resource poor counties around the world. However, the rich genetic diverstiy of the otherwise low productive animal population offers opportunity for the control of Johne's disease and improve per animal productivity. Present review aims to gather and compile information available on genetics or resistance to Johne's disease and its future exploitation by resource poor countries rich in animal diversity. This review will also help to create awareness and share knowledge and experience on prevalence and opportunities for control of Johne's disease in the livestock population to boost per animal productivity among developing and poor countries of the world. Breeding of animals for disease resistance provides good, safe, effective and cheaper way of controlling Johne's disease in animals, with especial reference to domestic livestock of developing and poor countries. Study will help to establish better understanding of the correlation between host cell factors and resistance to MAP infection which may have ultimately help in the control of Johne's disease in future.
Microbiology Lab., Animal Health Division, Central Institute for Research on Goats, Makhdoom, PO-Farah, Mathura (UP)-281122, India.
Shoor
S
Vir Singh
Division of Pathology, Indian Veterinary Research Institute, Izatnagar, Bareilly (UP)-243 122, India.
Kuldeep
K
Dhama
Microbiology Lab., Animal Health Division, Central Institute for Research on Goats, Makhdoom, PO-Farah, Mathura (UP)-281122, India.
Kundan Kumar
KK
Chaubey
Microbiology Lab., Animal Health Division, Central Institute for Research on Goats, Makhdoom, PO-Farah, Mathura (UP)-281122, India.
Naveen
N
Kumar
National JALMA Institute for Leprosy and Other Mycobacterial Diseases (NJIL and OMD), TajGanj, Agra (UP)-282001, India.
Pravin Kumar
PK
Singh
Canadian Food Inspection Agency, 3400 W Casavant, St. Hyacihthe (QC), Canada-J2S 8E3, Canada.
Jagdip Singh
JS
Sohal
Microbiology Lab., Animal Health Division, Central Institute for Research on Goats, Makhdoom, PO-Farah, Mathura (UP)-281122, India.
Saurabh
S
Gupta
Microbiology Lab., Animal Health Division, Central Institute for Research on Goats, Makhdoom, PO-Farah, Mathura (UP)-281122, India.
Ajay
A
Vir Singh
Department of Veterinary Epidemiology and Preventive Medicine, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, (UP)-281001, India.
Amit Kumar
AK
Verma
Department of Microbiology and Immunology, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, (UP)-281001, India.
Ruchi
R
Tiwari
Department of Animal Nutrition, Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya Evam Go-Anusandhan Sansthan (DUVASU), Mathura, (UP)-281001, India.
Mahima
Animal Resource Development Department, Pt. Nehru Complex, Agartala, Tripura-799001, India.
S
S
Chakraborty
Animal Genetics and Breeding, Project Directorate on Cattle, Indian Council of Agricultural Research, Grass farm Road, Meerut, Uttar Pradesh-250001, India.
Rajib
R
Deb
D000818:Animals; D000829:Animals, Domestic; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions / Q000235:genetics*; D016927:Mycobacterium avium subsp. paratuberculosis / Q000472:pathogenicity*; D010283:Paratuberculosis / Q000235:genetics* / Q000382:microbiology* / Q000517:prevention & control; D010641:Phenotype; D011379:Prognosis; D012418:Ruminants / Q000235:genetics* / Q000382:microbiology*; D013045:Species Specificity