[Establishment of three-dimensional integrated "serum pharmacochemistry-pharmacokinetics (pharmacodynamics)-systems biology" for research of traditional Chinese medicine prescription and its application in Yinchenhao Tang].
Traditional Chinese medicine (TCM) prescription is a valuable asset for clinical medication, has multi-component and multi-target characteristics. However, due to the complex ingredients of prescription, the unclear mechanism, the lack of scientific data to support the dose-response relationship, it has become the bottleneck for the in-depth study for the process of modernization and internationalization of TCM. It requires the integration of Chinese medicine theory, modern analysis and data mining technology to build new research model for characteristic of TCM prescription. This paper provides an overview of TCM serum pharmacochemistry, pharmacokinetics (pharmacodynamics) and systems biology theory and practice, to establish the integrated three-dimensional "serum pharmacochemistry-pharmacokinetics (pharmacodynamics)-systems biology" for the research of TCM prescription to reveal the pharma-material basis and action mechanism and the compatibility scientific connotation, with a prescription Yinchenhao Tang as a case study.
National Traditional Chinese Medicine Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Ai-Hua
AH
Zhang
National Traditional Chinese Medicine Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Hui
H
Sun
National Traditional Chinese Medicine Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Guang-Li
GL
Yan
National Traditional Chinese Medicine Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Ying
Y
Han
National Traditional Chinese Medicine Key Laboratory of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Xi-Jun
XJ
Wang
D000818:Animals; D011307:Drug Prescriptions / Q000592:standards*; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics* / Q000592:standards; D006801:Humans; D011786:Quality Control; D044967:Serum / Q000737:chemistry*; D049490:Systems Biology
D004365:Drugs, Chinese Herbal