Fully interlocking: a story of teamwork among breast epithelial cells.
In this issue of Developmental Cell, Forster et al. (2014) show that the basal myoepithelial cell layer directs the final maturation of the adjacent luminal cell sheet during pregnancy. Do all mammary epithelial cells both give and take instructions from others to create the milk production machinery?
McArdle Laboratory for Cancer Research, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: alexander@oncology.wisc.edu.
Caroline M
CM
Alexander
Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada.
Purna A
PA
Joshi
Ontario Cancer Institute, University of Toronto, Toronto M5G 2M9, Ontario, Canada.
Rama
R
Khokha
D053687:Adult Stem Cells / Q000378:metabolism*; D000818:Animals; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D007774:Lactation; D020890:Neuregulin-1 / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D011247:Pregnancy; D015534:Trans-Activators / Q000378:metabolism*
D020890:Neuregulin-1; C490581:Nrg1 protein, mouse; D010750:Phosphoproteins; D015534:Trans-Activators; C486419:Trp63 protein, mouse