Radiolabeled NGR phage display peptide sequence for tumor targeting.
The asparagine-glycine-arginine (NGR) peptide sequence found by phage display, was radiolabeled with technetium-99m and tested in different tumor models. Similar uptake occurred with ovarian and lung tumor cells. Biodistribution of the radiotracer revealed predominant renal excretion with more substantial uptake in animals bearing ovarian tumor cells. In contrast imaging studies indicated better visualization for lung tumor. NGR peptide was characterized as a promising diagnostic candidate, particularly for lung cancer. Improvements are envisaged using NGR combined with RGD as a heterodimer molecule.
Radiopharmacy, Institute of Energy and Nuclear Research, Av. Prof. Lineu Prestes 2242, 05508-000 São Paulo, SP, Brazil. Electronic address: blfaintuch@hotmail.com.
B L
BL
Faintuch
Radiopharmacy, Institute of Energy and Nuclear Research, Av. Prof. Lineu Prestes 2242, 05508-000 São Paulo, SP, Brazil.
E A
EA
Oliveira
Laboratory of Biopharmacology in Animal Cells, Butantan Institute, Av. Vital Brazil 1500, 05503900 São Paulo, SP, Brazil.
R C
RC
Targino
Laboratory of Biopharmacology in Animal Cells, Butantan Institute, Av. Vital Brazil 1500, 05503900 São Paulo, SP, Brazil.
A M
AM
Moro
D000818:Animals; D045744:Cell Line, Tumor; D005260:Female; D008175:Lung Neoplasms / Q000175:diagnosis; D008297:Male; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis*; D009842:Oligopeptides; D010051:Ovarian Neoplasms / Q000175:diagnosis; D019151:Peptide Library; D019275:Radiopharmaceuticals / Q000737:chemistry; D013667:Technetium / Q000737:chemistry
C526428:NGR peptide; D009842:Oligopeptides; D019151:Peptide Library; D019275:Radiopharmaceuticals; D013667:Technetium
Cyclic NGR peptide; Imaging; Radiolabeled