Thinking outside the Osp(G)--kinase activation by E2-ubiquitin.
OspG is a secreted effector kinase from the human pathogen Shigella that is required for the reduction of immune responses during Shigella infection. A new study in The EMBO Journal provides a co-crystal structure of OspG bound to UbcH5c~Ub, revealing how a bacterial kinase can be activated by the host ubiquitin conjugation machinery. These results provide molecular insight into an enigmatic microbial virulence factor that thwarts the host immune surveillance system to cause disease.
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Maarten F
MF
de Jong
Neal M
NM
Alto
D000818:Animals; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism*; D012763:Shigella flexneri / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism*
D025801:Ubiquitin; D037521:Virulence Factors; C097310:UBE2D3 protein, human; D044763:Ubiquitin-Conjugating Enzymes; D011494:Protein Kinases