Retinal ganglion cell maps in the brain: implications for visual processing.
Everything the brain knows about the content of the visual world is built from the spiking activity of retinal ganglion cells (RGCs). As the output neurons of the eye, RGCs include ∼20 different subtypes, each responding best to a specific feature in the visual scene. Here we discuss recent advances in identifying where different RGC subtypes route visual information in the brain, including which targets they connect to and how their organization within those targets influences visual processing. We also highlight examples where causal links have been established between specific RGC subtypes, their maps of central connections and defined aspects of light-mediated behavior and we suggest the use of techniques that stand to extend these sorts of analyses to circuits underlying visual perception.
Department of Neurosciences, University of California, San Diego, United States; Neurobiology Section in the Division of Biological Sciences, University of California, San Diego, United States. Electronic address: odhande@ucsd.edu.
Onkar S
OS
Dhande
Department of Neurosciences, University of California, San Diego, United States; Neurobiology Section in the Division of Biological Sciences, University of California, San Diego, United States; Department of Ophthalmology, University of California, San Diego, United States. Electronic address: ahuberman@ucsd.edu.
Andrew D
AD
Huberman
D000818:Animals; D001931:Brain Mapping; D006801:Humans; D012165:Retinal Ganglion Cells / Q000166:cytology* / Q000502:physiology*; D014793:Visual Cortex / Q000166:cytology / Q000502:physiology; D014795:Visual Pathways / Q000166:cytology* / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*