Toll-like receptor 2 in serum: a potential diagnostic marker of prosthetic joint infection?
Prosthetic joint infection (PJI) is a severe complication of arthroplasty and is still lacking diagnostic gold standards. PJI patients display high Toll-like receptor 2 (TLR2) serum levels, correlating with canonical inflammatory markers (C-reactive protein [CRP], interleukin 6 [IL-6], tumor necrosis factor alpha [TNF-α], and IL-1). Therefore, TLR2 serum levels could be considered a new potential diagnostic tool in the early detection of PJI.
Department of Biomedical, Surgical and Oral Science, Università degli Studi di Milano, Milan, Italy.
Emanuela
E
Galliera
Lorenzo
L
Drago
Christian
C
Vassena
Carlo
C
Romanò
Monica
M
Gioia Marazzi
Lucia
L
Salcito
Massimiliano M
MM
Corsi Romanelli
D000368:Aged; D000369:Aged, 80 and over; D001168:Arthritis / Q000175:diagnosis* / Q000473:pathology; D001178:Arthroplasty / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood*; D042241:Early Diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000473:pathology; D044967:Serum / Q000737:chemistry*; D051195:Toll-Like Receptor 2 / Q000097:blood*
D015415:Biomarkers; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2