JAK-STAT in lipid metabolism of adipocytes.
JAK-STAT signaling pathway plays an important role in the cells' development and homeostasis. Over the past decades, the studies have identified the role of the JAK-STAT pathway in cell proliferation and apoptosis. Here, we want to discuss that whether and how the JAK-STAT pathway affects the lipid metabolism of adipose tissue. A host of cytokines and hormones can regulate lipid metabolism through activating the JAK-STAT signaling pathway. Activated STATs can regulate lipid metabolism directly by influencing the expression of enzymes. We have summarized the relevant research and articles of JAK-STAT during the recent years. Within this review, we will introduce you the recent research and highlight the unresolved problems in understanding how JAK-STAT signaling pathway contribute to the lipid metabolism in mature adipocytes and preadipocytes. Dysregulation of the JAK-STAT pathway would lead to a multiple metabolism disorders and medicines for this signaling pathway maybe become a new idea for diseases such as metabolic syndrome, especially in children.
Department of Pediatrics; Second Affiliated Hospital of Medical School of Xi'an; Jiaotong University; Xi'an, Shaanxi PR China.
Dong
D
Xu
Department of Pediatrics; Second Affiliated Hospital of Medical School of Xi'an; Jiaotong University; Xi'an, Shaanxi PR China.
Chunyan
C
Yin
Department of Pediatrics; Second Affiliated Hospital of Medical School of Xi'an; Jiaotong University; Xi'an, Shaanxi PR China.
Sisi
S
Wang
Department of Pediatrics; Second Affiliated Hospital of Medical School of Xi'an; Jiaotong University; Xi'an, Shaanxi PR China.
Yanfeng
Y
Xiao
JAK-STAT; adipocytes; lipid metabolism; obesity; preadipocytes