Cerebrospinal fluid neuropeptide Y in combat veterans with and without posttraumatic stress disorder.
Accruing evidence indicates that neuropeptide Y (NPY), a peptide neurotransmitter, is a resilience-to-stress factor in humans. We previously reported reduced cerebrospinal fluid (CSF) NPY concentrations in combat-related posttraumatic stress disorder (PTSD) subjects as compared with healthy, non-combat-exposed volunteers. Here we report CSF NPY in combat-exposed veterans with and without PTSD. We quantified NPY concentrations in morning CSF from 11 male subjects with PTSD from combat in Iraq and/or Afghanistan and from 14 combat-exposed subjects without PTSD. NPY-like immunoreactivity (NPY-LI) was measured by EIA. The relationship between CSF NPY and clinical symptoms, as measured by the Clinician-Administered PTSD Scale (CAPS) and Beck Depression Inventory (BDI), was assessed, as was the relationship between combat exposure scale (CES) scores and CSF NPY. As compared with the combat-exposed comparison subjects without PTSD, individuals with PTSD had significantly lower concentrations of CSF NPY [mean CSF NPY was 258. 6 ± 21.64 pg/mL in the combat trauma-no PTSD group but only 180.5 ± 12.62 pg/mL in PTSD patients (p=0.008)]. After adjusting for CES and BDI scores the two groups were still significantly different with respect to NPY. Importantly, CSF NPY was negatively correlated with composite CAPS score and intrusive (re-experiencing) subscale scores, but did not significantly correlate with CES or BDI scores. Our current findings further suggest that NPY may regulate the manifestation of PTSD symptomatology, and extend previous observations of low CSF NPY concentrations in the disorder. Central nervous system NPY may be a clinically important pharmacotherapeutic target, and/or diagnostic measure, for PTSD.
Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Research Service, Veterans Affairs Medical Center, Cincinnati, OH, USA. Electronic address: sahr@uc.edu.
Renu
R
Sah
Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Research Service, Veterans Affairs Medical Center, Cincinnati, OH, USA.
Nosakhare N
NN
Ekhator
Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Research Service, Veterans Affairs Medical Center, Cincinnati, OH, USA; Psychiatry Service, Veterans Affairs Medical Center, Cincinnati, OH, USA.
Lena
L
Jefferson-Wilson
Department of Mathematical Sciences, University of Cincinnati, Cincinnati, OH, USA; Research Service, Veterans Affairs Medical Center, Cincinnati, OH, USA.
Paul S
PS
Horn
Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA; Research Service, Veterans Affairs Medical Center, Cincinnati, OH, USA; Psychiatry Service, Veterans Affairs Medical Center, Cincinnati, OH, USA.
Thomas D
TD
Geracioti
D000328:Adult; D055826:Afghan Campaign 2001-; D016022:Case-Control Studies; D003130:Combat Disorders / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000453:epidemiology; D006801:Humans; D054542:Iraq War, 2003-2011; D008297:Male; D009478:Neuropeptide Y / Q000134:cerebrospinal fluid*; D013313:Stress Disorders, Post-Traumatic / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000453:epidemiology; D014728:Veterans / Q000706:statistics & numerical data; D055815:Young Adult
D009478:Neuropeptide Y
Anxiety; Brain; Cerebrospinal fluid (CSF); Depression; Mood; Neuropeptide Y (NPY); Post-traumatic stress disorder (PTSD); Resilience