[Undifferentiated carcinoma of the jejunum producing granulocyte colony-stimulating factor].
An 80-year-old man presented with abdominal fullness and vomiting. Laboratory data revealed severe anemia, an inflammatory response, and elevated white blood cell counts. Abdominal computed tomography indicated ileus caused by a jejunal tumor measuring 8cm in diameter. Although small-bowel endoscopy enabled visualization of the tumor, adequate biopsy specimens could not be obtained for accurate diagnosis. The patient's condition rapidly deteriorated, because of which surgical treatment could not be initiated. The patient died approximately 3 weeks after admission. High serum granulocyte colony-stimulating factor (G-CSF) levels were detected at autopsy. Immunohistochemical staining of the autopsy specimen indicated positive G-CSF levels in the jejunal tumor. On the basis of these findings, a final diagnosis of undifferentiated carcinoma of the jejunum producing G-CSF was made.
Department of Gastroenterology, Yokosuka Kyosai Hospital.
Nobukatsu
N
Horita
Hiroko
H
Nagata
Tatsuo
T
Morinushi
Nahoko
N
Inoue
Eri
E
Ito
Makoto
M
Hara
Haruna
H
Ida
Yumi
Y
Ito
Yoko
Y
Tanabe
Hideki
H
Watanabe
Katsuharu
K
Arai
Hideaki
H
Suzuki
Fumie
F
Kobayashi
Takaaki
T
Ikeda
Yukio
Y
Tsuura
D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D002277:Carcinoma / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D003115:Colony-Stimulating Factors / Q000032:analysis* / Q000096:biosynthesis* / Q000276:immunology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D045823:Ileus / Q000000981:diagnostic imaging / Q000209:etiology; D007150:Immunohistochemistry; D007580:Jejunal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D003115:Colony-Stimulating Factors