Urinary tract infection pathogenesis: host factors.
Clinically, host factors in the pathogenesis of urinary tract infection (UTI) may be considered as modifiable (eg, behaviors associated with increased risk of UTI, anatomic and functional problems of the urinary tract) and thus potentially amenable to a change in patient behavior or treatment approach, or as intrinsic and nonmodifiable host factors that neither the patient nor the clinician can influence (eg, gender and genetic influences associated with UTI). Although considering nonmodifiable host factors may be discouraging to patients and clinicians at present, some genetic associations have the potential for future predictive value and may interface with future treatments.
Division of Allergy and Infectious Diseases, Medicine, Institute of Translational Health Sciences, University of Washington, Box 356423, Room BB1233, 1959 Northeast Pacific Street, Seattle, WA 98195, USA; Clinical Research Center, Institute of Translational Health Sciences, University of Washington, 7 South UWMC, Box 356178, 1959 Northeast Pacific Street, Seattle, WA 98195, USA. Electronic address: stapl@uw.edu.
Ann E
AE
Stapleton
D005260:Female; D015438:Health Behavior; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D012737:Sex Factors; D014552:Urinary Tract Infections / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D014566:Urogenital System / Q000382:microbiology
Estrogen status; Female gender; Modifiable host factors; Nonmodifiable host factors; Sexual intercourse; Urogenital microbiota