Do we need a new vaccine to control the re-emergence of pertussis?
Bordetella pertussis causes whooping cough and is re-emerging in developed countries despite widespread immunization with acellular pertussis vaccines (Pa), which are less effective than the whole cell vaccines that they replaced. Efficacy of Pa could be improved by switching from alum to alternative adjuvants that generate more potent cell mediated immunity.
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: kingston.mills@tcd.ie.
Kingston H G
KH
Mills
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Pádraig J
PJ
Ross
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Aideen C
AC
Allen
School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.
Mieszko M
MM
Wilk
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D001886:Bordetella pertussis / Q000276:immunology* / Q000302:isolation & purification*; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D010567:Pertussis Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D014611:Vaccination / Q000379:methods*; D022282:Vaccines, Acellular / Q000008:administration & dosage / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology* / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D010567:Pertussis Vaccine; D022282:Vaccines, Acellular
Bordetella pertussis; Th1 cell; adjuvant; cell mediated immunity; vaccine; whooping cough