Synthesis of 1-(4-aminobutyl)-2-iminoimidazolidin-4-one aimed at preparation of a creatinine-specific antibody.
For the purpose of obtaining a creatinine-specific antibody, a creatinine derivative with 4-aminobutyl, which was served as a linker for preparing the creatinine-bovine serum albumin (BSA) conjugate, was synthesized from 4-benzylaminobutan-1-ol in 8 steps. Production of anti-creatinine antibodies was observed in two rabbits using the creatinine-BSA conjugate, although their titer was rather low.
Translational Medical Research Center, Tokyo Metropolitan Institute of Medical Science.
Shun-suke
SS
Moriya
Naoki
N
Terayama
Kyoko
K
Hiramatsu
Masao
M
Kawakita
Tatsuya
T
Kiryu
Takato
T
Kawanishi
Eiko
E
Yasui
Shinji
S
Nagumo
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D060326:Chemistry Techniques, Synthetic; D003404:Creatinine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000737:chemistry
C000597989:1-(4-aminobutyl)-2-iminoimidazolidin-4-one; D000906:Antibodies; D012710:Serum Albumin, Bovine; C094390:2-iminoimidazolidin-4-one; D003404:Creatinine