Organocatalytic one-pot synthesis of highly substituted pyridazines from Morita-Baylis-Hillman carbonates and diazo compounds.
A biologically inspired organocatalytic one-pot synthesis of highly functionalized pyridazines, which are ubiquitous structural units in a number of biologically active compounds, has been developed by starting from readily available diazo compounds and Morita-Baylis-Hillman (MBH) carbonates. Under mild reaction conditions, this synthetic route tolerated significant substrate variation to deliver a broad range of substituted products, including CF3 -substituted pyridazines derivatives. Moreover, the introduction of trifluoromethyl groups into the ring of pyridazine could be completed conveniently from 2,2,2-trifluorodiazoethane.
School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, 210093 (P. R. China).
Haibin
H
Mao
Aijun
A
Lin
Zhongkai
Z
Tang
Hongwen
H
Hu
Chengjian
C
Zhu
Yixiang
Y
Cheng
Morita-Baylis-Hillman carbonates; diazo compounds; one-pot synthesis; organocatalysis; pyridazines