[Trauma-induced coagulopathy].
The main cause of death in the patient group less than 45 years is trauma. Beside severe traumatic brain injury, bleeding remains a leading cause of death in this group. For a causal therapy, it is necessary to understand the pathophysiology of trauma-induced coagulopathy (TIC). Beside the well-known lethal triad of trauma (hypothermia, acidosis, and coagulopathy), dilution and hypoperfusion with activation of the protein C pathway play a crucial role. TIC is a complex independent syndrome which may be present without initial hypercoagulopathy. A rapid and differentiated diagnosis and goal-directed therapy is crucial for causal therapy.
Klinik für Anästhesiologie und Intensivmedizin, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland, hanke.alexander@mh-hannover.de.
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Hanke
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Rahe-Meyer
D001778:Blood Coagulation Disorders / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D004632:Emergency Medical Services / Q000379:methods*; D006801:Humans; D012771:Shock, Hemorrhagic / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D014947:Wounds and Injuries / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*