Adaptor protein STAP-2 modulates cellular signaling in immune systems.
Signal-transducing adaptor protein-2 (STAP-2) is a recently identified adaptor protein that contains a pleckstrin homology (PH), Src homology 2 (SH2)-like domains, and proline-rich regions in its C-terminal. STAP-2 belongs to a family of STAP adaptor proteins and plays a crucial role in a variety of cellular signal transduction pathways by interacting with signaling or transcriptional molecules. STAP-2, in particular, regulates both the innate and adaptive immune systems. STAP-2 functionally interacts with signal transducers and activators of transcription 3 (STAT3) and STAT5 in cytokine signaling pathways. In addition, STAP-2 also binds to myeloid differentiation factor 88 (MyD88) and inhibitor (I)κB kinase α/β (IKK-α/β) in Toll-like receptor4 (TLR4) signaling, and enhances the production of inflammatory cytokines in macrophages. More importantly, experiments using STAP-2 deficient mice show that STAP-2 modulates several T-cell functions such as cell motility, survival and death. It is also reported that STAP-2 controls the immunoglobulin E (IgE)-mediated allergy response. This accumulated evidence indicates that adaptor protein STAP-2 is an important modulator of both the innate and adaptive immune systems.
Cellular Neuroscience, Neurodegeneration and Repair Program,  Departments of Neurology and Neurobiology, Yale University School of Medicine.
Yuichi
Y
Sekine
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D007109:Immunity; D010750:Phosphoproteins / Q000378:metabolism*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D016207:Cytokines; D010750:Phosphoproteins; C413897:STAP2 protein, human