ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains.
BACKGROUND
Epigenome reader domains are rapidly emerging as a new class of drug targets for a wide array of human diseases. To facilitate study of structure-activity relationship and small-molecule ligand design for these domains, we have created ChEpiMod. ChEpiMod is a free knowledgebase of chemical modulators with documented modulatory activity for epigenome reader domains.


METHODS
ChEpiMod organizes information about chemical modulators and their associated binding-affinity data, as well as available structures of epigenome readers from the Protein Data Bank. The data are gathered from the literature and patents. Entries are supplemented by annotation. The current version of ChEpiMod covers six epigenome reader domain families (Bromodomain, PHD finger, Chromodomain, MBT, PWWP and Tudor). The database can be used to browse existing chemical modulators and bioactivity data, as well as, all available structures of readers and their molecular interactions. The database is updated weekly.


BACKGROUND
ChEpiMod is freely available at http://chepimod.org


BACKGROUND
ming-ming.zhou@mssm.edu


BACKGROUND
Supplementary data is available at Bioinformatics online.
Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY, 10029, USA.
Jamel
J
Meslamani
Steven G
SG
Smith
Roberto
R
Sanchez
Ming-Ming
MM
Zhou
D000595:Amino Acid Sequence; D030541:Databases, Genetic; D044127:Epigenesis, Genetic; D023281:Genomics / Q000379:methods*; D006801:Humans; D008024:Ligands; D008969:Molecular Sequence Data; D054852:Small Molecule Libraries / Q000378:metabolism*; D013329:Structure-Activity Relationship
D008024:Ligands; D054852:Small Molecule Libraries