Protein tyrosine phosphatase non-receptor type 22 gene polymorphism C1858T is not associated with leprosy in Azerbaijan, Northwest Iran.
BACKGROUND
Leprosy (Hansen's disease) is a human chronic granulomatous infectious disease caused by Mycobacterium leprae. Several types of study support a role for host genetics in susceptibility to leprosy. The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes an intracellular lymphoid protein tyrosine phosphatase that has been shown to play a negative regulatory role in T-cell activation.


OBJECTIVE
The aim of the present study was to find out associating the PTPN22 C1858T (R620W) polymorphism and leprosy in the Azeri population from Northwest Iran.


METHODS
A total of 153 treated leprosy patients and 197 healthy and ethnic matched controls entered this study. We used restriction fragment length polymorphism method to type PTPN22 C1858T polymorphism.


RESULTS
There was no significant difference in distribution of genotype and allele frequencies of PTPN22 C1858T polymorphism between leprosy patients and controls (P = 0.641 and 0.645; respectively). Moreover, there was no significant association between different clinical findings (karnofsky performance status score, clinical forms and manifestations of leprosy) and PTPN22 C1858T polymorphism. Data showed a low frequency of the minor (T) allele by 2.3% in leprosy and 1.5% in healthy individuals.


CONCLUSIONS
The PTPN22 C1858T (R620W) is not relevant in susceptibility to leprosy in the Azeri population of Northwest Iran.
Drug Applied Research Center; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Reza
MR
Aliparasti
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Shohreh
S
Almasi
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Jafar
J
Majidi
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Fatemeh
F
Zamani
Bababaghi Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Ali Reza
AR
Khoramifar
Bababaghi Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Ali Reza Farshi
AR
Azari
Gene polymorphism; leprosy; protein tyrosine phosphatase non-receptor type 22