Mycobacteria and the greasy macrophage: getting fat and frustrated.
In the current issue of Infection and Immunity, Caire-Brändli and coworkers (Infect. Immun. 82:476-490, 2014, doi:10.1128/IAI.01196-13) describe a novel cell system for studying mycobacterial interactions with foamy macrophages and provide a magnificent series of electron microscopy-based observations providing major insight into the microbiology and cell biology of these interactions.
Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France, and Université de Toulouse, Université Paul Sabatier, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France.
Olivier
O
Neyrolles
D000818:Animals; D005260:Female; D050356:Lipid Metabolism; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008264:Macrophages / Q000382:microbiology*; D009162:Mycobacterium avium / Q000254:growth & development* / Q000378:metabolism*
D008079:Lipoproteins, VLDL