A new diketopiperazine from the gorgonian coral Menella kanisa.
Chemical investigation on the gorgonian Menella kanisa collected from Beibu Gulf led to the isolation of a new diketopiperazine, named menazepine A (1), as well as three known diketopiperazines, namely cyclo(4-hydroxyprolylleucyl) (2), cyclo(Pro-Leu) (3) and cyclo(4-hydroxyprolylphenylalanyl) (4). The structure of the new diketopiperazine was elucidated on the basis of extensive spectroscopic analysis and by comparing the data with those of related metabolites. Compounds 1-4 were also evaluated for brine shrimp lethality.
a Guangxi Key Laboratory of Marine Environmental Science , Guangxi Academy of Sciences , Nanning 530-007 , P.R. China.
Chenghai
C
Gao
Lin
L
Lin
Bin
B
Long
Yinning
Y
Chen
Bijuan
B
He
Haiyan
H
Sun
Riming
R
Huang
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001156:Artemia / Q000187:drug effects; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004151:Dipeptides / Q000302:isolation & purification; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000302:isolation & purification
D054659:Diketopiperazines; D004151:Dipeptides; D010456:Peptides, Cyclic; C505275:cyclo(prolyl-leucyl); C018170:prolylleucine