Gut microbial metabolites of polyunsaturated fatty acids correlate with specific fecal bacteria and serum markers of metabolic syndrome in obese women.
The aim of this human study was to assess the influence of prebiotic-induced gut microbiota modulation on PUFA-derived bacterial metabolites production. Therefore, we analyzed the circulating fatty acid profile including CLA/CLnA in obese women treated during 3 months with inulin-type fructan prebiotics. In these patients, we had already determined gut microbiota composition by phylogenetic microarray and qPCR analysis of 16S rDNA. Some PUFA-derived bacterial metabolites were detected in the serum of obese patients. Despite the prebiotic-induced modulation of gut microbiota, including changes in CLA/CLnA-producing bacteria, the treatment did not impact significantly on the circulating level of these metabolites. However, some PUFA-derived bacterial metabolites were positively correlated with specific fecal bacteria (Bifidobacterium spp., Eubacterium ventriosum and Lactobacillus spp.) and inversely correlated with serum cholesterol (total, LDL, HDL). These correlations suggest a potential beneficial effect of some of these metabolites but this remains to be confirmed by further investigation.
Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Avenue E. Mounier 73, PO box B1.73.11, 1200, Brussels, Belgium.
Céline
C
Druart
Evelyne M
EM
Dewulf
Patrice D
PD
Cani
Audrey M
AM
Neyrinck
Jean-Paul
JP
Thissen
Nathalie M
NM
Delzenne
D000328:Adult; D000368:Aged; D001644:Bifidobacterium / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000097:blood* / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005260:Female; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D024821:Metabolic Syndrome / Q000097:blood* / Q000382:microbiology / Q000473:pathology; D054892:Metagenome; D064307:Microbiota; D009765:Obesity / Q000097:blood* / Q000382:microbiology / Q000473:pathology; D010802:Phylogeny; D056692:Prebiotics; D012336:RNA, Ribosomal, 16S / Q000235:genetics
D005231:Fatty Acids, Unsaturated; D056692:Prebiotics; D012336:RNA, Ribosomal, 16S