Iridium-catalyzed direct C-H amidation with weakly coordinating carbonyl directing groups under mild conditions.
An iridium-catalyzed direct C-H amidation of weakly coordinating substrates, in particular of those bearing ester and ketone groups, under very mild conditions has been developed. The observed high reaction efficiency was achieved by the combined use of acetic acid and lithium carbonate as additives.
Center for Catalytic Hydrocarbon Functionalization, Institute of Basic Science (IBS), Daejeon 305-701 (Republic of Korea); Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701 (Republic of Korea).
Jinwoo
J
Kim
Sukbok
S
Chang
CH amidation; azides; esters; iridium; weakly coordinating groups