Cognitive function in multiple sclerosis: a subcortical pattern of neuropsychological impairment?
In order to evaluate cognitive impairment in multiple sclerosis (MS) neuropsychological tests were administered to 25 patients with clinically definite disease. Four (16%) showed diffuse cognitive impairment, whereas the others, compared with controls showed a specific deficit on tests known to be sensitive to frontal lobe damage. These results are interpreted in the light of current hypotheses relating to subcortical contributions in cognition.
Neurologic Clinic, 2nd University of Rome, Ospedale S. Eugenio, P. le dell'Umanesimo, 10, 00144 Roma, Italy.
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Caltagirone
Neurologic Clinic, 2nd University of Rome, Ospedale S. Eugenio, P. le dell'Umanesimo, 10, 00144 Roma, Italy.
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Carlesimo
Neurologic Clinic, 2nd University of Rome, Ospedale S. Eugenio, P. le dell'Umanesimo, 10, 00144 Roma, Italy.
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Fadda
Neurologic Clinic, 2nd University of Rome, Ospedale S. Eugenio, P. le dell'Umanesimo, 10, 00144 Roma, Italy.
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Roncacci