Family history of myocardial infarction increases risk of renal dysfunction in middle age.
OBJECTIVE
Chronic kidney disease (CKD) is common in the general population, may lead to end-stage renal disease, and is most frequently found among males. Familial clustering of kidney diseases has been observed. We aimed to study a potential association between the family history of myocardial infarction (MI) and renal dysfunction.


METHODS
22,297 males and 10,828 females, aged 33-60 years, from a population-based cohort study were studied. Estimated glomerular filtration rate (eGFR) was assessed by the CKD-EPI creatinine equation. Every participant filled in a self-administered questionnaire including family history. Heredity for MI was defined as mother or father having had MI and/or died from MI, and/or brother or sister having had MI. Binary logistic regression and multiple linear regression were used in the analyses.


RESULTS
Multiple linear regression revealed a significantly increased risk of renal dysfunction in those with a positive heredity for MI (the whole cohort p = 0.01, males p = 0.000, females p = 0.169). Binary logistic regression showed that males with heredity for MI with a mean age of 43 years have a 2 times higher risk (p = 0.02) of belonging to the group with GFR <45 ml/min/1.73 m(2) compared to those without heredity. For the whole cohort the increased risk was 1.6 times (p = 0.07). There was no significant association for females (p = 0.88).


CONCLUSIONS
These findings demonstrate that a familial burden of MI is associated with renal dysfunction, in men, already in middle age. Genetic variants may underlie predisposition to CKD in those with heredity for MI.
Department of Nephrology and Transplantation, Skåne University Hospital, Lund University, Malmö, Sweden.
Anders
A
Christensson
Olle
O
Melander
Erik
E
Fjellstedt
Maria
M
Ohlson-Andersson
D000328:Adult; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000235:genetics; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D060730:Glomerular Filtration Barrier; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology / Q000235:genetics; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology* / Q000235:genetics*; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D011795:Surveys and Questionnaires