NK-cell fratricide: Dynamic crosstalk between NK and cancer cells.
The intercellular transfer of plasma membrane patches, also known as trogocytosis, has a strong impact on the function and fate of immune cells. We have recently shown that natural killer (NK) cells undergo fratricide following the trogocytosis-mediated acquisition of tumor-derived NKG2D ligands. Malignant cells may therefore employ trogocytosis to escape NKG2D-mediated immune responses.
Department of Immunobiology; Institute of Development; Aging and Cancer; Tohoku University; Sendai, Japan ; Department of Hematology and Rheumatology; Tohoku University Graduate School of Medicine; Sendai, Japan.
Kyohei
K
Nakamura
Department of Immunobiology; Institute of Development; Aging and Cancer; Tohoku University; Sendai, Japan.
Masafumi
M
Nakayama
Department of Immunobiology; Institute of Development; Aging and Cancer; Tohoku University; Sendai, Japan.
Mitsuko
M
Kawano
Department of Hematology and Rheumatology; Tohoku University Graduate School of Medicine; Sendai, Japan.
Tomonori
T
Ishii
Department of Hematology and Rheumatology; Tohoku University Graduate School of Medicine; Sendai, Japan.
Hideo
H
Harigae
Department of Immunobiology; Institute of Development; Aging and Cancer; Tohoku University; Sendai, Japan.
Kouetsu
K
Ogasawara
NK cells; NKG2D; trogocytosis