Effect of platelet rich fibrin and beta tricalcium phosphate on bone healing. A histological study in pigs.
OBJECTIVE
To investigate the effect of platelet rich fibrin (PRF) and beta tricalcium phosphate (β-TCP), alone or in combination, on bone regeneration in pig tibial defects.


METHODS
Four standardized defects were prepared in both tibias of three adult male pigs. The first defect was left unfilled as a control; the others were grafted with either PRF, β-TCP or PRF mixed with β-TCP. All animals were sacrificed on the 12th postoperative week and the tibial bones were removed, histologic sections were prepared and the experimental sites were examined microscopically and stereologically.


RESULTS
Histologic and stereologic examination revealed more new bone formation in the defects filled with PRF mixed β-TCP than in the defects grafted with either β-TCP or PRF alone.


CONCLUSIONS
The platelet rich fibrin and beta tricalcium phosphate combination effectively induces new bone formation.
Ardahan Military Hospital, Ardahan, Turkey.
Dincer
D
Yilmaz
Gulhane Military Medical Academy, Dental Sciences Center, Department of Oral and Maxillofacial Surgery, Ankara, Turkey.
Necdet
N
Dogan
Land Forces Practice Center, Ankara, Turkey.
Aydin
A
Ozkan
Gulhane Military Medical Academy, Dental Sciences Center, Department of Oral and Maxillofacial Surgery, Ankara, Turkey.
Metin
M
Sencimen
Gulhane Military Medical Academy, Dental Sciences Center, Department of Oral and Maxillofacial Surgery, Ankara, Turkey.
Baris Eren
BE
Ora
Gulhane Military Medical Academy, Dental Sciences Center, Department of Oral and Maxillofacial Surgery, Ankara, Turkey.
Ibrahim
I
Mutlu
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects*; D002130:Calcium Phosphates / Q000627:therapeutic use*; D005337:Fibrin / Q000627:therapeutic use*; D008297:Male; D010012:Osteogenesis / Q000502:physiology*; D013552:Swine; D013977:Tibia / Q000293:injuries
D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D005337:Fibrin