[Immune pathogenesis of IgA nephropathy and its drugable targets].
IgA nephropathy (IgAN) is recognized as the most common immune complex related to the cause of glomerulonephritis worldwide. The disease is characterized by the predominant deposition of underglycosylated IgA1 in the mesangial area of glomeruli. Dysregulation of the immune system plays an important role in the pathogenesis of IgAN. Abnormalities restricted to T lymphocytes and/or B lymphocytes activation could be a critical causative factor in the over-production of underglycosylated IgA1.
Department of Nephrology, Sencond Xiangya Hospital, Central South University, Changsha 410011, China.
Liyu
L
He
Hong
H
Liu
Youming
Y
Peng
D000936:Antigen-Antibody Complex; D001402:B-Lymphocytes; D005920:Glomerular Mesangium; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D006801:Humans; D007070:Immunoglobulin A / Q000737:chemistry*; D013601:T-Lymphocytes
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A