Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
The present work reports the anti-inflammatory and antinociceptive activities of the ethanol extract obtained from the stem bark of Sterculia striata A. St.-Hil. & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate. The Ss-EtOH (50 mg/kg) promoted a marked inhibition on the hind paw edema induced by carrageenan or dextran (30% and 73%, respectively). Besides, Ss-EtOH (25 mg/kg) exhibited a slight activity (30%) on the hind paw edema induced by histamin. The Ss-EtOH (12.5 and 25 mg/kg) showed the antinociceptive activity on chemical stimuli induced by acetic acid (65.59% and 38.37%, respectively), formalin, in the initial (35.08% and 31.5%, respectively) and late phases (44.09% and 83.57%, respectively), capsaicin (43.77% and 51.31%, respectively), or glutamate (36.6% and 52.12%, respectively). Regarding the possible mechanism involved in the antinociceptive effect, Ss-EtOH (12.5 mg/kg) showed a decrease in the antinociceptive effect (65.8%) in the acetic acid model after pretreatment with naloxone. Thus, opioid mechanisms might be underlying this response.
1 Medicinal Plants Research Center, Federal University of Piauí , Teresina, PI, Brazil .
Francilene V
FV
Silva
Irisdalva S
IS
Oliveira
Kayo A
KA
Figueiredo
Francisco B Melo
FB
Júnior
Danielly A
DA
Costa
Mariana H
MH
Chaves
Maurício P M
MP
Amaral
Fernanda R C
FR
Almeida
Francisco A
FA
Oliveira
Rita C M
RC
Oliveira
D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002211:Capsaicin; D002351:Carrageenan; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005557:Formaldehyde; D018698:Glutamic Acid; D006632:Histamine; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018547:Plant Stems; D017208:Rats, Wistar; D032361:Sterculia
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D003911:Dextrans; D010936:Plant Extracts; D005557:Formaldehyde; D009270:Naloxone; D018698:Glutamic Acid; D006632:Histamine; D002351:Carrageenan; D019342:Acetic Acid; D002211:Capsaicin
Sterculia striata; anti-inflammatory; antinociceptive; carrageenan; opioid; paw edema