Recent advances in personalized colorectal cancer research.
Colorectal cancer is one of the most prevalent cancers and a leading cause ofcancer-related death. It is also curable if detected early. The prognosis for metastatic colorectal cancer remains poor and resistance to chemotherapy is still a major obstacle in effective treatment. While many patients do not clinically benefit from chemotherapy, others experience adverse reactions resulting in dose modifications or treatment withdrawal, thereby reducing treatment efficacy. Researchefforts attempt to identify reliable biomarkers which will guide clinicians in decision making, while matching suitable therapeutic regimens. We here review currently known molecular biomarkers used for the personalized treatment of colorectal cancer.
The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Sarah
S
Kraus
The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Ilana
I
Nabiochtchikov
The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Shiran
S
Shapira
The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: nadira@tlvmc.gov.il.
Nadir
N
Arber
D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D044127:Epigenesis, Genetic; D018734:Genes, erbB-2; D011905:Genes, ras; D006801:Humans; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics; D011110:Polymorphism, Genetic; D057285:Precision Medicine; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D019869:Phosphatidylinositol 3-Kinases; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf
Biomarkers; Colorectal cancer (CRC); Epigenetic markers; KRAS; Monoclonal antibodies (mAbs); Oncotype