Maternal high-fat diet during pregnancy and lactation reduces the appetitive behavioral component in female offspring tested in a brief-access taste procedure.
Maternal high-fat diet appears to disrupt several energy balance mechanisms in offspring. Here, female offspring from dams fed a high-fat diet (HF) did not significantly differ in body weight compared with those fed chow (CHOW), when weaned onto chow diet. Yet when presented with both a chow and a high-fat diet, high-fat intake was significantly higher in HF compared with CHOW offspring. To assess taste-based responsiveness, offspring (12 wk old) were tested in 30-min sessions (10-s trials) to a sucrose concentration series in a brief-access taste test. Compared with CHOW, the HF offspring initiated significantly fewer trials but did not significantly differ in the amount of concentration-dependent licking. Thus, rather than affect lick response (consummatory), maternal diet affects spout approach (appetitive), which may be attributed to motivation-related mechanisms. Consistent with this possibility, naltrexone, an opioid receptor antagonist, further reduced trial initiation, but not licking in both groups. With naltrexone administration, the group difference in trial initiation was no longer evident, suggesting differences in endogenous opioid activity between the two groups. Relative expression of μ-opioid receptor in the ventral tegmental area was significantly lower in HF rats. When trial initiation was not required in one-bottle intake tests, no main effect of maternal diet on the intake of sucrose and corn oil emulsions was observed. Thus, the maternal high-fat diet-induced difference in diet preference is not likely due to changes in the sensory orosensory component of the taste stimulus but may depend on alterations in satiety signals or absorptive mechanisms.
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore Maryland.
Yada
Y
Treesukosol
Bo
B
Sun
Alexander A
AA
Moghadam
Nu-Chu
NC
Liang
Kellie L
KL
Tamashiro
Timothy H
TH
Moran
D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight; D002755:Choice Behavior; D003314:Corn Oil / Q000008:administration & dosage; D059305:Diet, High-Fat; D019422:Dietary Sucrose / Q000008:administration & dosage; D004326:Drinking; D004435:Eating; D005260:Female; D005518:Food Preferences; D007774:Lactation; D039382:Maternal Nutritional Physiological Phenomena; D009042:Motivation; D009292:Narcotic Antagonists / Q000494:pharmacology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism; D012528:Satiety Response; D013649:Taste / Q000187:drug effects; D013997:Time Factors; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000378:metabolism
D019422:Dietary Sucrose; D009292:Narcotic Antagonists; D017450:Receptors, Opioid, mu; D003314:Corn Oil
appetitive; fat; maternal diet; motivation; sweet