[Based on hospital information system data, analysis of effects of different doses of shenmai injection on renal function].
OBJECTIVE
To assess whether the dosage of Shenmai injection influences renal function.


METHODS
Analysis of hospital information system (HIS) data from 18 national hospitals using Shenmai injections. Patients were aged between 18 to 80 years old. Blood analysis of creatinine and serum urea nitrogen was undertaken 7 days before and after exceeding the maximum recommended dose of 100 mL of Shenmai injection. Propensity score method was used to compare the differences between the two groups of renal function scores.


RESULTS
The differences in abnormal changes in creatinine and serum urea nitrogen levels between the groups before and after exceeding the recommended dose was not statistically significant, but abnormal changes were detected.


CONCLUSIONS
Based on the available data we did not find that exceeding the recommended dose of Shenmai injection had a significantly deleterious effect on renal function. However, caution should be applied in its clinical use.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. studentjiangjunjie@163.com
Jun-Jie
JJ
Jiang
Renmin University of China, Beijing 100872, China.
Hao
H
Tang
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Yan-Ming
YM
Xie
Renmin University of China, Beijing 100872, China.
Hu
H
Yang
The PLA Navy General Hospital, Beijing 100048, China.
Yan
Y
Zhuang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001806:Blood Urea Nitrogen; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D054796:Drug Dosage Calculations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006751:Hospital Information Systems / Q000706:statistics & numerical data; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D064792:Pragmatic Clinical Trials as Topic; D057216:Propensity Score; D012189:Retrospective Studies; D014508:Urea / Q000097:blood; D055815:Young Adult
D004365:Drugs, Chinese Herbal; D014508:Urea; D003404:Creatinine