Bioactive limonoids from the leaves of Azaridachta indica (Neem).
Eight new limonoids (1-8) and one new phenol glycoside (9), along with six known compounds, were isolated from the leaves of Azaridachta indica. The structures of 1-9 were elucidated on the basis of spectroscopic data analysis. Compounds isolated were assayed for their cytotoxicity against different cancer cell lines. Moreover, their ability to interact with the molecular chaperone Hsp90, affecting its biological activity, was tested.
Laboratorio de Medicamentos Organicos Sector Campo de Oro, Departamento de Farmacognosia y Medicamentos Organicos, Universidad de Los Andes , detras del HULA, Mérida, 5101, Venezuela.
Maria J
MJ
Gualtieri
Nicola
N
Malafronte
Antonio
A
Vassallo
Alessandra
A
Braca
Roberta
R
Cotugno
Michele
M
Vasaturo
Nunziatina
N
De Tommasi
Fabrizio
F
Dal Piaz
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031601:Azadirachta / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D014687:Venezuela
D000972:Antineoplastic Agents, Phytogenic; D018841:HSP90 Heat-Shock Proteins; D036701:Limonins