Encapsulating peritoneal sclerosis in the era of a multi-disciplinary approach based on biocompatible solutions: the NEXT-PD study.
BACKGROUND
Encapsulating peritoneal sclerosis (EPS) is a serious complication of peritoneal dialysis (PD). Over the past decade in Japan, a multidisciplinary approach has been adopted to minimize the incidence and improve outcomes of EPS. This strategy includes planned PD discontinuation for high-risk patients and the introduction of biocompatible solutions. This study examined the current clinical status of EPS in representative PD centers in Japan.


METHODS
Patients (n = 1,338) from 55 PD centers in Japan who were using neutral-pH solutions from the initiation of therapy (mean age, 62 years; median PD duration, 32 months; concomitant use of icodextrin, 35.2%; PD and hemodialysis combination therapy, 12.2%) were assessed every 6 months to ascertain the reasons for PD discontinuation and the development of EPS development. Outcomes were also recorded. The study period was from November 2008 to March 2012.


RESULTS
There were 727 patients who discontinued PD, including 163 deaths. Among all causes of PD withdrawal except for death, planned PD discontinuation to avoid EPS was utilized in 58 cases (7.1% in total). The strategy was increasingly utilized in proportion to the duration of PD: 0.5% for patients undergoing PD for < 3 years, 0.6% for patients undergoing PD for 5 years, 14.7% for patients undergoing PD for 8 years, and 35.5% for patients undergoing PD for > 8 years. Fourteen patients developed EPS (three cases after PD), which corresponded with an overall incidence of 1.0%. The incidence according to the duration of PD was 0.3% for PD < 3 years, 0.6% for PD = 5 years, 2.3% for PD = 8 years, and 1.2% for PD > 8 years. In terms of therapy, 11 patients were treated with prednisolone (PSL), and surgical enterolysis was utilized in two cases. Complete remission of abdominal symptoms was achieved in twelve patients (85.7%), and three died due to EPS (mortality rate of 21.4%).


CONCLUSIONS
Use of the multidisciplinary approach described above reduces the risk of the development of EPS according to PD duration. In cases of de novo EPS cases in Japan, this strategy can also attenuate the clinical course of the condition.
Tohoku University Graduate School of Medicine, Sendai, Japan; Fukushima Medical University School of Medicine, Fukushima, Japan; Miyazaki Clinic, Nagasaki, Japan; Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Fuji City General Hospital, Fuji, Japan; Oita University School of Medicine, Oita, Japan; Saitama Medical University, Saitama, Japan; and Tsuchiya General Hospital, Hiroshima, Japan Tohoku University Graduate School of Medicine, Sendai, Japan; Fukushima Medical University School of Medicine, Fukushima, Japan; Miyazaki Clinic, Nagasaki, Japan; Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Fuji City General Hospital, Fuji, Japan; Oita University School of Medicine, Oita, Japan; Saitama Medical University, Saitama, Japan; and Tsuchiya General Hospital, Hiroshima, Japan.
Masaaki
M
Nakayama
Tohoku University Graduate School of Medicine, Sendai, Japan; Fukushima Medical University School of Medicine, Fukushima, Japan; Miyazaki Clinic, Nagasaki, Japan; Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Fuji City General Hospital, Fuji, Japan; Oita University School of Medicine, Oita, Japan; Saitama Medical University, Saitama, Japan; and Tsuchiya General Hospital, Hiroshima, Japan.
Masanobu
M
Miyazaki
Tohoku University Graduate School of Medicine, Sendai, Japan; Fukushima Medical University School of Medicine, Fukushima, Japan; Miyazaki Clinic, Nagasaki, Japan; Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Fuji City General Hospital, Fuji, Japan; Oita University School of Medicine, Oita, Japan; Saitama Medical University, Saitama, Japan; and Tsuchiya General Hospital, Hiroshima, Japan.
Kazuho
K
Honda
Tohoku University Graduate School of Medicine, Sendai, Japan; Fukushima Medical University School of Medicine, Fukushima, Japan; Miyazaki Clinic, Nagasaki, Japan; Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Fuji City General Hospital, Fuji, Japan; Oita University School of Medicine, Oita, Japan; Saitama Medical University, Saitama, Japan; and Tsuchiya General Hospital, Hiroshima, Japan.
Kenji
K
Kasai
Tohoku University Graduate School of Medicine, Sendai, Japan; Fukushima Medical University School of Medicine, Fukushima, Japan; Miyazaki Clinic, Nagasaki, Japan; Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Fuji City General Hospital, Fuji, Japan; Oita University School of Medicine, Oita, Japan; Saitama Medical University, Saitama, Japan; and Tsuchiya General Hospital, Hiroshima, Japan.
Tadashi
T
Tomo
Tohoku University Graduate School of Medicine, Sendai, Japan; Fukushima Medical University School of Medicine, Fukushima, Japan; Miyazaki Clinic, Nagasaki, Japan; Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Fuji City General Hospital, Fuji, Japan; Oita University School of Medicine, Oita, Japan; Saitama Medical University, Saitama, Japan; and Tsuchiya General Hospital, Hiroshima, Japan.
Hidetomo
H
Nakamoto
Tohoku University Graduate School of Medicine, Sendai, Japan; Fukushima Medical University School of Medicine, Fukushima, Japan; Miyazaki Clinic, Nagasaki, Japan; Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Fuji City General Hospital, Fuji, Japan; Oita University School of Medicine, Oita, Japan; Saitama Medical University, Saitama, Japan; and Tsuchiya General Hospital, Hiroshima, Japan.
Hideki
H
Kawanishi
D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D015314:Dialysis Solutions / Q000494:pharmacology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects* / Q000379:methods; D056627:Peritoneal Fibrosis / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D019233:Retreatment / Q000379:methods; D018570:Risk Assessment; D015996:Survival Rate; D016896:Treatment Outcome; D028761:Withholding Treatment
D001672:Biocompatible Materials; D015314:Dialysis Solutions
Peritoneal dialysis; encapsulating peritoneal sclerosis; neutral solution