Effects of daily intake of yoghurt enriched with bioactive components on chronic stress responses: a double-blinded randomized controlled trial.
Chronic stress has a negative influence on health. The aim was to determine stress reducing effects of yoghurt enriched with bioactive components as compared to normal yoghurt. High-trait anxiety individuals (n = 67) aged 18-63 years participated in a randomized, placebo-controlled, double-blinded intervention with parallel groups. They received either yoghurt enriched with alpha-lactalbumin, casein tripeptides and B vitamins (active) or isoenergetic standard yoghurt (control). To detect changes in psychological and physiological stress, State-Trait Anxiety Inventory, Profile of Mood States, salivary cortisol, inflammatory markers, blood pressure, heart rate variability (HRV) and actigraphy were monitored. We observed higher ratings of vigor (p = 0.047) and reduced feeling of inefficiency (p = 0.048) in the active group. HRV (baseline adjusted mean 49.1 ± 2.3 ms) and recovery index (106.6 ± 33.4) were higher in the active group than in controls (42.5 ± 2.2 ms and 80.0 ± 29.3) (p = 0.046 and p = 0.02, respectively). In conclusion, daily intake of yoghurt enriched with bioactive components may aid in stress coping.
Department of Pharmacology, Institute of Biomedicine, University of Helsinki , Helsinki , Finland .
Nora
N
Jaatinen
Riitta
R
Korpela
Tuija
T
Poussa
Anu
A
Turpeinen
Sari
S
Mustonen
Juho
J
Merilahti
Katri
K
Peuhkuri
D000223:Adaptation, Psychological; D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000178:diet therapy* / Q000503:physiopathology / Q000523:psychology; D015415:Biomarkers / Q000378:metabolism; D002364:Caseins / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D005527:Food, Fortified; D006801:Humans; D007768:Lactalbumin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000627:therapeutic use; D010446:Peptide Fragments / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D013315:Stress, Psychological / Q000517:prevention & control; D014803:Vitamin B Complex / Q000627:therapeutic use*; D015014:Yogurt; D055815:Young Adult
D015415:Biomarkers; D002364:Caseins; D009842:Oligopeptides; D010446:Peptide Fragments; D014803:Vitamin B Complex; D007768:Lactalbumin
B vitamins; bioactive peptides; sleep; stress; yoghurt; α-Lactalbumin