Palladium-catalyzed direct thiolation of aryl C-H bonds with disulfides.
A catalytic variant of the direct thiolation of arenes, bearing directing groups, with disulfides or thiols has been developed under palladium and copper co-catalysis. Both sulfenyl moieties of the disulfide could be incorporated into the thiolated products, therefore, the reactions reached completion with only half an equivalent of disulfide, with respect to the starting arene. Experimental evidence suggested that the reaction proceeds through a Pd(II)/Pd(IV) mechanism.
Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530 (Japan), Fax: (+81) 86-251-7855.
Masayuki
M
Iwasaki
Miki
M
Iyanaga
Yuta
Y
Tsuchiya
Yugo
Y
Nishimura
Wenjuan
W
Li
Zhiping
Z
Li
Yasushi
Y
Nishihara
2-arylpyridine; aryl sulfides; direct thiolation; disulfides; palladium