Elevated Th22 cells correlated with Th17 cells in peripheral blood of patients with acute myeloid leukemia.
Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains unclear. Here, we investigated frequencies of Th22, Th17, pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. We demonstrated that Th22, Th17, and pure Th17 in newly-diagnosed (ND) and non-complete remission (Non-CR) AML patients and plasma IL-22 in ND AML patients were significantly increased. Retinoid-related orphan receptor C (RORC) expression was significantly elevated in CR and Non-CR AML patients. However, Th1 in ND AML patients and IL-17 in ND, Non-CR or CR AML patients was significantly decreased compared with controls. Moreover, Th22 and IL-22 showed positive correlation with pure Th17, but Th22 showed negative correlation with Th1 in ND AML patients. RORC showed positive correlation with Th22 and approximately positive correlation with pure Th17 in Non-CR patients. PB blast cell showed positive correlation with Th22 and negative correlation with Th1 in ND AML patients. Our results indicate that Th22 and pure Th17 cells conjointly contribute to the pathogenesis of AML and might be promising novel clinical index for AML.
Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. yussdu@gmail.com.
Shuang
S
Yu
Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. liucfsy@gmail.com.
Chuanfang
C
Liu
Department of Orthopedics, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250012, China. zhanglsdu@gmail.com.
Lei
L
Zhang
Department of Stomatology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China. sbzsdu@gmail.com.
Baozhong
B
Shan
Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. tiantian0621010155@gmail.com.
Tian
T
Tian
Department of Oncology, Qilu Hospital, Shandong University, Jinan 250012, China. huysdu@gmail.com.
Yu
Y
Hu
Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. shaollsy@gmail.com.
Linlin
L
Shao
Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. sunyxsdu@gmail.com.
Yuanxin
Y
Sun
Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. jichunyan@sdu.edu.cn.
Chunyan
C
Ji
Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. daoxinma@sdu.edu.cn.
Daoxin
D
Ma
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D016130:Immunophenotyping; D007378:Interleukins / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000235:genetics; D012074:Remission Induction; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult; D000097043:Interleukin-22
D016207:Cytokines; D007378:Interleukins; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D000097043:Interleukin-22; C539900:RORC protein, human