The effect of pseudophakia on retinal and cortical functions.
OBJECTIVE
To investigate the effect of pseudophakia on visual electrophysiology.


METHODS
Right eyes of 60 pseudophakic (study group) age- and sex-matched 60 phakic (control group) volunteers were included. Subjects without any ocular and systemic disease, who had visual acuity of more than 9/10 underwent full-field electroretinogram (ERG), pattern electroretinogram (PERG), pattern visual evoked potentials (PVEP) and electro-oculogram (EOG) recordings.


RESULTS
The P100 latency to 1º-check was significantly shorter in both pseudophakic groups (study group: 102.98 ± 6.11, control group: 107.06 ± 10.70, p=0.012). The P100 amplitude to 15'-check was significantly higher in the pseudophakic groups (study group: 13.96 ± 7.01, control group: 11.60 ± 4.69, p: 0.033). Regarding ERG, b-wave implicit time in rod response and a-wave implicit time in standard combined response (SCR) were significantly shorter in the pseudophakic group (p=0.017, and less than 0.001, respectively). B-wave amplitude in rod response and a-wave amplitude in SCR were significantly higher in the study group (p less than 0.001 for both). The P1 and N1 amplitude and implicit time differences in 30-Hz flicker response were not significant (p more than 0.05). Conversely, P3/P4 implicit times in oscillatory potentials (OPs) were delayed in the pseudophakic group (p=0.001, and 0.002, respectively). The P1 amplitude increase in OPs in the study group was significant (p less than 0.001). The N95 latency in PERG was significantly delayed (p=0.002) and P50 amplitude was increased (p=0.002) in the pseudophakics. Arden ratio in EOG was similar in both groups (p=0.961).


CONCLUSIONS
Pseudophakia seems to influence ocular electrophysiological tests. Possible causes of these influences in the patients with pseudophakia should be clarified by further studies.
1Department of Ophthalmology, Izmir Military Hospital, Izmir, 2Department of Ophthalmology, GATA Medical Faculty, Ankara; Turkey.
Fahrettin
F
Akay
Fatih M
FM
Mutlu
Fatih C
FC
Gundogan
D000368:Aged; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000503:physiopathology*; D004585:Electrooculography; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D019591:Pseudophakia / Q000503:physiopathology*; D012160:Retina / Q000503:physiopathology*