Neutrophil gelatinase-associated lipocalin after off pump versus on pump coronary artery surgery.
BACKGROUND
Cardiac surgery.


OBJECTIVE
To compare plasma and urinary neutrophil gelatinase-associated lipocalin (P-/U-NGAL) in on-pump (n = 43) versus off-pump (n = 40) surgery.


METHODS
We obtained perioperative P-/U-NGAL and outcome data.


RESULTS
P-/U-NGAL increased after surgery. P-NGAL was higher post-surgery in on pump patients (139 versus 67 µg L(-1); p < 0.001), but not at 24 h. There were no differences in U-NGAL. Correlation between P-/U-NGAL and plasma creatinine was weak.


CONCLUSIONS
P-NGAL acts like a neutrophil activation biomarker and U-NGAL like a tubular injury marker.


CONCLUSIONS
On-pump patients had greater neutrophil activation. On- versus off-pump surgery had similar impact on tubular cells.
Department of Surgical sciences, Section of Anaesthesiology & Intensive Care, Uppsala University , Uppsala , Sweden .
Miklos
M
Lipcsey
Philip
P
Hayward
Michael
M
Haase
Ania
A
Haase-Fielitz
Glenn
G
Eastwood
Leah
L
Peck
George
G
Matalanis
Rinaldo
R
Bellomo
D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology / Q000652:urine; D000209:Acute-Phase Proteins / Q000652:urine; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D003324:Coronary Artery Disease / Q000097:blood* / Q000601:surgery / Q000652:urine; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood* / Q000652:urine; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood* / Q000652:urine; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000097:blood* / Q000652:urine; D016896:Treatment Outcome
D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine