Metal-free oxidative amidation of 2-oxoaldehydes: a facile access to α-ketoamides.
A novel and efficient method for the synthesis of α-ketoamides, employing a dimethyl sulfoxide (DMSO)-promoted oxidative amidation reaction between 2-oxoaldehydes and amines under metal-free conditions is presented. Furthermore, mechanistic studies supported an iminium ion-based intermediate as a central feature of reaction wherein C1-oxygen atom of α-ketoamides is finally derived from DMSO.
Medicinal Chemistry Division, ‡Academy of Scientific and Innovative Research (AcSIR), §Quality Control and Quality Assurance (QC & QA), Indian Institute of Integrative Medicine (IIIM) , Jammu, Jammu and Kashmir 180016, India.
Nagaraju
N
Mupparapu
Shahnawaz
S
Khan
Satyanarayana
S
Battula
Manoj
M
Kushwaha
Ajai Prakash
AP
Gupta
Qazi Naveed
QN
Ahmed
Ram A
RA
Vishwakarma
D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000447:Aldehydes; D000577:Amides; D004121:Dimethyl Sulfoxide