[Comparative pharmacokinetic studies of borneol in brain and plasma of stroke or sham-operated rats after administration of Xingnaojing].
In order to research the pharmacokinetic characteristic of borneol in plasma and brain of stroke rats given XNJ and investigate the influence of stroke on the borneol passing through the blood-brain barrier, this study established the GC to determine the borneol in brain and blood, and made the stroke mode rats by middle carotid artery occlusion (MCAO) and set sham-operated group. After oral administration of Xingnaojing (XNJ) suspension, their blood and brain were collected at different time and detected by GC. The data was analysed by Kinetica. Results showed that in stroke group, the Cmax and AUC0-t of brain and plasma are (1.82 +/- 0.825), (1.35 +/- 0.43) mg x L(-1) and (123.39 +/- 55.82), (87.91 +/- 39.81) mg x L(-1) x min, Te (brain/blood drug ratio) was 70.93%; those pharmacokinetic values were larger than in sham-operated group. We can conclude that the pathological state of stroke can increase the amount of borneol permeating into brain.
Beijing University of Chinese Medicine, Beijing 100102, China. clamslowly@163.com
Pan
P
Xu
Beijing University of Chinese Medicine, Beijing 100102, China.
Shou-Ying
SY
Du
Beijing University of Chinese Medicine, Beijing 100102, China.
Ying
Y
Li
Beijing University of Chinese Medicine, Beijing 100102, China.
Yang
Y
Lu
Beijing University of Chinese Medicine, Beijing 100102, China.
Jie
J
Bai
Beijing University of Chinese Medicine, Beijing 100102, China.
Qing-Li
QL
Guo
D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001892:Camphanes / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D010949:Plasma / Q000737:chemistry / Q000378:metabolism*; D020521:Stroke / Q000188:drug therapy* / Q000378:metabolism
D001892:Camphanes; D004365:Drugs, Chinese Herbal; C022871:isoborneol