Antioxidant and anticancer activities of selected persian gulf algae.
In the present study, the effect of red (Gracillaria corticata), green (Ulva fasciata) and brown (Sargassum ilicifolium) seaweeds alcoholic extract, against five important human cancer cell lines (MCF-7, MDA-MB-231, HeLa, HepG2, and HT-29) proliferation, apoptosis and cell cycle arrest were evaluated. The reducing activity and total polyphenol content were also investigated. MTT assay was used for cytotoxicity test. Morphological alterations were examined using phase contrast, fluorescent and electron microscopy. All the extracts were antiproliferative against all the cancer cell lines, dose-dependently, with G. corticata methanol extract (GCME) having the greatest inhibition activity against MCF-7 cell line. The percentage of apoptosis increased from 18 to 78 %. The cell cycle analysis also showed that GCME can induce apoptosis which confirm by TEM. Algal extract reducing activities were as follows: G. corticata > S. ilicifolium > U. fasciata. The GCME is a good source of potential complementary and alternative functional food for prevention and treatment of cancer.
Faculty of Medicine, Applied Biology Research Centre, Mashhad Branch, Islamic Azad University, Mashhad, Iran ; Institute of Tropical Forestry and Forest Products (INTROP), Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Malaysia.
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Namvar
Faculty of Science, Applied Biology Research Centre, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
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Baharara
Department of Biochemistry, King George's Medical University, Lucknow, India.
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Mahdi
Antioxidant; Apoptosis; Cytotoxicity; Persian Gulf; Seaweeds