Dendritic signal transmission induced by intracellular charge inhomogeneities.
Signal propagation in neuronal dendrites represents the basis for interneuron communication and information processing in the brain. Here we take into account charge inhomogeneities arising in the vicinity of ion channels in cytoplasm and obtain a modified cable equation. We show that charge inhomogeneities acting on a millisecond time scale can lead to the appearance of propagating waves with wavelengths of hundreds of micrometers. They correspond to a certain frequency band predicting the appearance of resonant properties in brain neuron signaling. We also show that membrane potential in spiny dendrites obeys the modified cable equation suggesting a crucial role of the spines in dendritic subthreshold resonance.
Institute of Applied Physics of Russian Academy of Science, 46 Uljanov street, 603950 Nizhny Novgorod, Russia and N.I. Lobachevsky State University of Nizhni Novgorod, 23 Gagarin avenue, 603950 Nizhny Novgorod, Russia.
Ivan A
IA
Lazarevich
Institute of Applied Physics of Russian Academy of Science, 46 Uljanov street, 603950 Nizhny Novgorod, Russia and N.I. Lobachevsky State University of Nizhni Novgorod, 23 Gagarin avenue, 603950 Nizhny Novgorod, Russia.
Victor B
VB
Kazantsev
D002462:Cell Membrane / Q000378:metabolism; D049229:Dendritic Spines / Q000378:metabolism*; D042541:Intracellular Space / Q000378:metabolism*; D007473:Ion Channels / Q000378:metabolism; D008959:Models, Neurological; D009435:Synaptic Transmission
D007473:Ion Channels