Genetic variants associated with myocardial infarction and the risk factors in Chinese population.
BACKGROUND
Recent genome-wide association (GWA) studies in Caucasians identified multiple single nucleotide polymorphisms (SNPs) associated with coronary artery disease (CAD). The associations of those SNPs with myocardial infarction (MI) have not been replicated in Asian populations. Among those previously identified SNPs, we selected nine (rs10953541, rs1122608, rs12190287, rs12413409, rs1412444, rs1746048, rs3798220, rs4977574, rs579459, in or near genes 7q22, LDLR, TCF21, CYP17A1, LIPA, CXCL12, LPA, CDKN2A, ABO, respectively) because of the relatively high minor allele frequencies in Chinese individuals and tested the associations of the SNPs with MI and MI related risk factors in Chinese population.


RESULTS
We conducted a case-control association study on a cohort of 2365 MI patients and 2678 unrelated controls from the Chinese population. Genotyping of 9 SNPs were performed by the TaqMan Real Time PCR method. After age, sex, and BMI adjustment, we observed the SNPs rs12190287, rs12413409, rs1412444, rs1746048 and rs4977574, were significantly associated with MI in additive models and rs12190287, rs12413409, rs4977574 were significantly associated with phenotypes of MI at the same time. We also found three SNPs rs1122608, rs3798220 and rs579459 were significantly associated with risk factors of MI, although they had no association with MI in Chinese population.


CONCLUSIONS
Results of this study indicate that 5 SNPs were associated with MI and 3 SNPs were associated with associated with lipoprotein levels but not with MI in a Chinese population. The present study supports some CAD-related genes in Caucasian as important genes for MI in a Chinese population.
Department of Cardiology, First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China ; Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China ; School of Basic Courses, Baotou Medical College, Baotou, Neimenggu, China.
Yongqin
Y
Wang
Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, China.
Lefeng
L
Wang
Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China ; Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, China.
Xin
X
Liu
Department of Cardiology, First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China ; Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
Yongzhi
Y
Zhang
Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, China.
Liping
L
Yu
Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, China.
Fan
F
Zhang
Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China.
Lisheng
L
Liu
Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, China.
Jun
J
Cai
Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, China.
Xinchun
X
Yang
Department of Cardiology, First Affiliated Hospital, Medical College of Shantou University, Shantou, Guangdong, China ; Laboratory of Human Genetics, Beijing Hypertension League Institute, Beijing, China ; Department of Cardiology, Chaoyang Hospital, Capital Medical University, Beijing, China.
Xingyu
X
Wang
D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008074:Lipoproteins / Q000097:blood; D009203:Myocardial Infarction / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors
D008074:Lipoproteins