Birth outcomes of pregnancies fathered by men with multiple sclerosis.
We linked several population-based clinical and health administrative databases in British Columbia, Canada. We identified and compared birth outcomes of pregnancies fathered by men with multiple sclerosis (MS) (n=202) and men from a frequency-matched general population cohort (n=981) between 1996 and 2010. Using multivariate models, we analyzed the association of paternal MS, disease duration at conception and disability (as measured by the Expanded Disability Status Scale) with birth weight and gestational age. Paternal MS and MS-related clinical factors were not significantly associated with birth outcomes (p>0.05). This study provides assurance to expecting fathers with MS and their families.
Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, Canada Vancouver Coastal Health Research Institute, Canada.
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Lu
Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, Canada Vancouver Coastal Health Research Institute, Canada.
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Zhu
Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, Canada.
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Zhao
Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, Canada Vancouver Coastal Health Research Institute, Canada Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
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van der Kop
Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, Canada Vancouver Coastal Health Research Institute, Canada Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
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Sadovnick
Vancouver Coastal Health Research Institute, Canada Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
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Synnes
Vancouver Coastal Health Research Institute, Canada Department of Obstetrics and Gynaecology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
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Dahlgren
Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, Canada Vancouver Coastal Health Research Institute, Canada.
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Traboulsee
Brain Research Centre and Department of Medicine (Division of Neurology), Faculty of Medicine, University of British Columbia, Vancouver, Canada Vancouver Coastal Health Research Institute, Canada helen.tremlett@ubc.ca.
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Tremlett
D001724:Birth Weight; D001955:British Columbia / Q000453:epidemiology; D016208:Databases, Factual; D004185:Disability Evaluation; D005220:Fathers; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D016014:Linear Models; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology*; D015999:Multivariate Analysis; D011247:Pregnancy; D011256:Pregnancy Outcome; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
Multiple sclerosis; birth; father; men; pregnancy