Recent progress in development of new sonosensitizers for sonodynamic cancer therapy.
Developing an effective treatment for cancer is still a challenge. Despite great success with traditional cancer therapies, there are numerous disadvantages for conventional treatments such as systemic toxicity, low selectivity, drug resistance and potential long-term side effects. Recently, photodynamic therapy (PDT) has been widely applied in clinical settings. However, this approach suffers from the major shortcoming derived from the limited penetrability of visible light. Sonodynamic therapy (SDT) utilizing ultrasound combined with a sonosensitizer represents a novel noninvasive approach for cancer therapy, which is deemed to overcome the disadvantage of PDT. In this review, we extensively summarize the recent progress in the discovery of new sonosensitizers for SDT and discuss the future directions for the development of novel sonosensitizers.
College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China. Electronic address: chenhaij@gmail.com.
Haijun
H
Chen
College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China.
Xiaobin
X
Zhou
College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China.
Yu
Y
Gao
College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China.
Biyuan
B
Zheng
College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China.
Fengxiang
F
Tang
College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350108, China. Electronic address: jdhuang@fzu.edu.cn.
Jiandong
J
Huang
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D054833:Isoindoles; D009369:Neoplasms / Q000628:therapy*; D011166:Porphyrins / Q000627:therapeutic use; D014464:Ultrasonic Therapy; D014966:Xanthenes / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D007211:Indoles; D054833:Isoindoles; D011166:Porphyrins; D014966:Xanthenes; C013647:phthalocyanine