Maternal characteristics and pregnancy outcomes after assisted reproductive technology by infertility diagnosis: ovulatory dysfunction versus tubal obstruction.
OBJECTIVE
To examine differences in maternal characteristics and pregnancy outcomes between women with ovulatory dysfunction (OD) and women with tubal obstruction (TO) who underwent assisted reproductive technology (ART).


METHODS
Retrospective cohort study.


METHODS
Centers for Disease Control and Prevention.


METHODS
Exposed and nonexposed groups were selected from the 2000-2006 National ART Surveillance System linked with live-birth certificates from three states: Florida, Massachusetts, and Michigan.


METHODS
None.


METHODS
Maternal characteristics and pregnancy outcomes, including newborn's health status right after delivery (Apgar score, <7 vs. ≥ 7) as the study outcome of interest, were assessed among women with OD/polycystic ovary syndrome (PCOS) and TO who used ART.


RESULTS
A significantly higher prevalence of women with OD/PCOS were younger (<35 years of age; 65.7% vs. 48.9%), were white (85.4% vs. 74.4%), had higher education (29.4% vs. 15.6%), and experienced diabetes (8.8% vs. 5.3%) compared with those having TO. The odds of having a lower (<7) Apgar score at 5 minutes were almost twice as high among newborns of women with OD/PCOS compared with those with TO (crude odds ratio, 1.86; 95% confidence interval [CI], 1.31, 2.64; adjusted odds ratio, 1.90; 95% CI, 1.30, 2.77).


CONCLUSIONS
Women with OD/PCOS who underwent ART have different characteristics and health issues (higher prevalence of diabetes) and infant outcomes (lower Apgar score) compared with women with TO.
Centers for Disease Control and Prevention, Atlanta, Georgia. Electronic address: vgrigorescu@cdc.gov.
Violanda
V
Grigorescu
Centers for Disease Control and Prevention, Atlanta, Georgia.
Yujia
Y
Zhang
Centers for Disease Control and Prevention, Atlanta, Georgia.
Dmitry M
DM
Kissin
Centers for Disease Control and Prevention, Atlanta, Georgia.
Erin
E
Sauber-Schatz
Centers for Disease Control and Prevention, Atlanta, Georgia.
Mithi
M
Sunderam
College of Public Health, University of South Florida, Tampa, Florida.
Russell S
RS
Kirby
Massachusetts Department of Public Health, Boston, Massachusetts.
Hafsatou
H
Diop
Michigan Department of Community Health, Lansing, Michigan.
Patricia
P
McKane
Centers for Disease Control and Prevention, Atlanta, Georgia.
Denise J
DJ
Jamieson
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D015897:Comorbidity; D005184:Fallopian Tube Diseases / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D008423:Maternal Age; D008875:Middle Aged; D009035:Mothers / Q000706:statistics & numerical data; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology* / Q000208:ethnology; D015995:Prevalence; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D044465:White People / Q000706:statistics & numerical data
Apgar score; Ovulatory dysfunction (OD); assisted reproductive technology (ART); polycystic ovary syndrome (PCOS); tubal obstruction (TO)