Golgi feels DNA's pain.
The Golgi apparatus consists of disc-like cisternae, stretching around the nucleus through forces exerted by F-actin and the Golgi membrane protein GOLPH3. Farber-Katz et al. now report that DNA damage triggers Golgi dispersal and inhibits vesicular transport through DNA-PK-mediated GOLPH3 phosphorylation, thereby linking the DNA damage response to Golgi regulation.
IFOM (Fondazione Istituto FIRC di Oncologia Molecolare), Via Adamello 16, 20139 Milan, Italy; Università degli Studi di Milano, Milan 20122, Italy. Electronic address: marco.foiani@ifom.eu.
Marco
M
Foiani
Danish Cancer Society Research Center, 2100 Copenhagen, Denmark; Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, 771 15 Olomouc, Czech Republic. Electronic address: jb@cancer.dk.
Jiri
J
Bartek
D000818:Animals; D004249:DNA Damage; D051747:DNA-Activated Protein Kinase / Q000378:metabolism*; D006056:Golgi Apparatus / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism*
D051747:DNA-Activated Protein Kinase; D008565:Membrane Proteins; D009218:Myosins; C429024:GOLPH3 protein, human; C407152:MYO18A protein, human