Jeavons syndrome in China.
OBJECTIVE
Jeavons syndrome (JS) is one of the underreported epileptic syndromes and is characterized by eyelid myoclonia (EM), eye closure-induced seizures or electroencephalography (EEG) paroxysms, and photosensitivity. In the Western populations, it has been reported to be characterized by focal posterior, occipital predominant epileptiform discharges (OPEDs) or frontal predominant epileptiform discharges (FPEDs) followed by generalized EDs in both interictal and ictal EEG recordings. However, it is not clear if there are different clinical manifestations between OPEDs and FPEDs. The clinical and electrographic presentations in the Chinese population are largely unknown. Here, we report the clinical and electroencephalographic features of 50 Chinese patients with JS and evaluate for the presence of different clinical features between patients with OPEDs and patients with FPEDs.


METHODS
We identified 50 cases who met the Jeavons syndrome criteria from 4230 patients with epilepsy at Xijing Hospital, Xi'an, China from the period of January 2010 to November 2011. These patients underwent long-term 24-hour video-EEG recording. Brain imaging was performed using magnetic resonance imaging (MRI) or computerized tomography (CT). Webster IQ testing was performed to determine intellectual development. We reviewed and described the interictal abnormalities, ictal EEG pattern, and demographic, clinical, and neuroimaging findings of these 50 Chinese patients in Xi'an. We divided the 50 patients into two groups according to the predominance of EDs and analyzed their clinical features.


RESULTS
Twenty-five of these 50 patients were male. Twenty-two out of 32 patients in the group with FPEDs were male, and 3/18 patients in the group with OPEDs were male. The median age of EMA-EM onset in FPEDs was 8years and that in OPEDs was 5.8years. Eyelid myoclonia occurred in all the 50 patients. Twenty-one out of 32 patients in the group with FPEDs had EM with absences, and 14/32 of them had EM with eyeball rolling up. Two out of 18 patients in the group with OPEDs had EM with absences, and only 1 of 18 had EM with eyeball rolling up.


CONCLUSIONS
Eyelid myoclonia with or without absences or JS diagnosis is easily missed and underreported in China. As an IGE, either the frontal or the occipital lobe may initiate generalized spike-and-wave discharges (GSWDs) and generalized seizures (GSs). There may be two subtypes of JS with distinctive clinical and electroencephalogrphic features: a predominantly male group with frontal predominant epileptiform discharges, eyelid myoclonia, and eyes rolling up and a predominantly female group with occipital predominant epileptiform discharges with eyelid myoclonia alone.
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Xiao-Li
XL
Wang
Department of Aerospace Physiology, Fourth Military Medical University, Xi'an 710032, PR China.
Jun-Xiang
JX
Bao
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Liang-Shi
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Tie-Ma
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Yan-Chun
YC
Deng
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Gang
G
Zhao
Neuroscience Institute, Kuala Lumpur Hospital, Malaysia. Electronic address: drswabengwei@gmail.com.
Bengwei
B
Swa
Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China. Electronic address: liuyhong@fmmu.edu.cn.
Yong-Hong
YH
Liu
D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D002681:China; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis* / Q000503:physiopathology; D004832:Epilepsy, Absence / Q000150:complications* / Q000175:diagnosis; D005143:Eyelids / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000175:diagnosis* / Q000503:physiopathology*; D009778:Occipital Lobe / Q000503:physiopathology; D012640:Seizures / Q000503:physiopathology; D013577:Syndrome; D014741:Video Recording
Eyelid myoclonia; Idiopathic generalized epilepsy; Jeavons syndrome; Photosensitivity