New limonoids from Coptidis Rhizoma-Euodiae Fructus couple.
A pair of inseparable new limonoids, named euodirutaecins A and B, were isolated from the Coptidis Rhizoma-Euodiae Fructus couple, together with two new single compounds evodirutaenin A and shihulimonin A1, and the known limonoids rutaevin, limonin, 12α-hydroxyrutaevin, and alkaloids rutaecarpine and evodiamine. Structures of these compounds were identified by spectral analyses and quantum chemical computational method, and the six limonoids were also evaluated for cytotoxicities against NCI-N87 and Caco-2 cell lines.
a State Key Laboratory of Natural and Biomimetic Drugs, Department of Natural Medicines , School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University , Beijing 100191 , China.
Ping
P
Qian
Hong-Wei
HW
Jin
Xiu-Wei
XW
Yang
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018938:Caco-2 Cells; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032086:Evodia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000502:physiology; D015394:Molecular Structure; D011799:Quinazolines / Q000737:chemistry / Q000302:isolation & purification; D027343:Rhizome / Q000737:chemistry; D052999:Quinazolinones
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids; D036701:Limonins; D011799:Quinazolines; C588342:euodirutaecin A; C588343:euodirutaecin B; C028632:rutecarpine; D052999:Quinazolinones; C049639:evodiamine