Dermacozines H-J isolated from a deep-sea strain of Dermacoccus abyssi from Mariana Trench sediments.
Dermacoccus abyssi sp. nov. strains MT1.1 and MT1.2 are actinomycetes isolated from a Mariana Trench sediment at a depth of 10 898 m. The fermentation process using complex media led to the production of three new pigmented heteroaromatic (oxidized and reduced) phenazine compounds, dermacozines H-J (1-3). Extensive use was made of 1D and 2D NMR experiments and high-resolution MS to determine the structures of the compounds. The new dermacozines showed radical scavenging activity, and the highest activity was observed for dermacozine H (1), with an IC50 value of 18.8 μM.
Mikrobiologisches Institut, Universität Tübingen , Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Marcell
M
Wagner
Wael M
WM
Abdel-Mageed
Rainer
R
Ebel
Alan T
AT
Bull
Michael
M
Goodfellow
Hans-Peter
HP
Fiedler
Marcel
M
Jaspars
D000192:Actinomycetales / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019015:Geologic Sediments / Q000737:chemistry; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction; D010619:Phenazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010802:Phylogeny; D010851:Picrates / Q000494:pharmacology
D001713:Biphenyl Compounds; D004269:DNA, Bacterial; D016166:Free Radical Scavengers; D010619:Phenazines; D010851:Picrates; C000590075:dermacozine H; C004931:1,1-diphenyl-2-picrylhydrazyl