Regulation of autophagy by TGF-β: emerging role in kidney fibrosis.
Autophagy is a highly conserved homoeostatic mechanism for cell survival under conditions of stress, and is widely implicated as an important pathway in many biological processes and diseases. In progressive kidney diseases, fibrosis represents the common pathway to end-stage kidney failure. Transforming growth factor-β1 (TGF-β1) is a pleiotropic cytokine that has been established as a central mediator of kidney fibrosis. A recently emerging body of evidence from studies in renal cells in culture and experimental animal models suggests that TGF-β1 regulates autophagy and that autophagy regulates many critical aspects of normal and disease conditions associated with kidney fibrosis, such as tubulointerstitial fibrosis, glomerulosclerosis, and diabetic nephropathy. Here, we review the recent advances exploring the process of autophagy, its regulation by TGF-β1, and the implication in the pathogenesis of progressive kidney fibrosis and injury responses. Understanding the cellular and molecular bases of this process is crucial for identifying potential new diagnostic and therapeutic targets of kidney fibrosis.
Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Nephrology and Hypertension, Weill Cornell Medical College, New York, NY.
Yan
Y
Ding
Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; Division of Nephrology and Hypertension, Weill Cornell Medical College, New York, NY. Electronic address: mechoi@med.cornell.edu.
Mary E
ME
Choi
D000818:Animals; D001343:Autophagy / Q000502:physiology*; D003928:Diabetic Nephropathies / Q000473:pathology; D005355:Fibrosis; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology; D050527:Mesangial Cells / Q000473:pathology; D011507:Proteinuria / Q000473:pathology; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology*
D016212:Transforming Growth Factor beta
Autophagy; chronic kidney disease; fibrosis; transforming growth factor-β1