[Using transient elastography as a screening tool for liver fibrosis in addiction service].
BACKGROUND
Most addictive behaviors are risk factors for chronic hepatitis. The level of liver fibrosis is the main prognostic factor of chronic hepatitis. Transient elastography is a valid and accessible tool for measuring the level of liver fibrosis. Its routine use in addiction service is however poorly documented.


OBJECTIVE
To test the feasibility of a systematic use of transient elastography as a tool for screening and diagnosis of liver fibrosis in patients hospitalized in an addiction medicine ward and to determine the prevalence of hepatic fibrosis, its predictive factors and etiologies and appreciate its evolution during alcohol detoxification.


METHODS
Two hundred and twenty-seven patients were included, hepatic elastography was measured by two operators according to the standards. Threshold of fibrosis (F1) was 8 kPa, threshold cirrhosis (F4) was 13 kPa.


RESULTS
Hepatic elastography was performed in 208 (92%) patients. A body mass index greater than 30 was associated with the non-feasibility of transient elastography, anti-HCV positive serology was associated with a lower reproductibility of transient elastography. Of the 208 patients, 61 had liver stiffness ≥ 8 kPa (prevalence of fibrosis of 29%), 25 had liver stiffness ≥ 13 kPa, fibrosis was not known for 46 (75%) of the 61 patients with fibrosis. A fibrosis was independently associated with the following variables: time between last alcohol ingestion and transient elastography measurement< 8 days, GGT>65 UI/L and serum concentration of platelets< 150 × 10(9)/L. Thirty patients had a second transient elastography in a median of 21 days after the first measurement. The decrease in liver stiffness during detoxification was significant only for patients whose alcohol ingestion was recent.


CONCLUSIONS
Our study confirmed that the measurement of liver stiffness by transient elastography was an efficient tool for the diagnosis and detection of liver fibrosis in patients with addictive behavior. The decrease in hepatic elastography during alcohol detoxification may serve as a motivational tool.
Hôpital Émile-Roux, pavillon Fouquet, service d'addictologie, 94450 Limeil-Brévannes, France. Electronic address: pierre.lahmek@erx.aphp.fr.
Pierre
P
Lahmek
Hôpital Émile-Roux, pavillon Fouquet, service d'addictologie, 94450 Limeil-Brévannes, France.
Nadine
N
Meunier
Centre Pierre-Nicole, 75005 Paris, France.
Laurent
L
Michel
Hôpital Paul-Brousse, pavillon Galilée, service d'addictologie, 94804 Villejuif, France.
Henri-Jean
HJ
Aubin
Hôpital Émile-Roux, pavillon Fouquet, service d'addictologie, 94450 Limeil-Brévannes, France.
Sylvain
S
Balester-Mouret
D000328:Adult; D000437:Alcoholism / Q000150:complications*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged