2-Trifluoromethylated indoles via radical trifluoromethylation of isonitriles.
Either two or three C-C bonds are formed in the synthesis of 2-trifluoromethylindoles starting with readily prepared isonitriles and the Togni reagent as CF3 radical precursor. These transformations occur in the absence of transition metal, and products are obtained in moderate to good yields with excellent diastereoselectivity.
Institute of Organic Chemistry, Westfälische Wilhems-University , Corrensstraße 40, 48149 Münster, Germany.
Bo
B
Zhang
Armido
A
Studer
D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism
D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D007211:Indoles; D009570:Nitriles; D003300:Copper