Sex-specific aging in flies, worms, and missing great-granddads.
Two recent studies identify how sex-specific pheromonal factors in flies and worms alter lifespan through metabolic pathways that are shared with mammals. Sex differences in human lifespans imply nonautonomous effects modulated by sex-specific gene-environment interactions that could still include pheromonal mechanisms.
Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: cefinch@usc.edu.
Caleb E
CE
Finch
Davis School of Gerontology and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA. Electronic address: jtower@usc.edu.
John
J
Tower
D000375:Aging; D000818:Animals; D005260:Female; D059647:Gene-Environment Interaction; D006801:Humans; D008017:Life Expectancy; D008297:Male; D023421:Models, Animal; D012727:Sex Characteristics