Cross Talk between Cellular Redox Status, Metabolism, and p53 in Neural Stem Cell Biology.
In recent years, the importance of the cellular redox status for neural stem cell (NSC) homeostasis has become increasingly clear. Similarly, the transcription factor and tumor suppressor p53 has been implicated in the regulation of cell metabolism, in antioxidant response, and in stem cell quiescence and fate commitment. Here, we explore the known and putative functions of p53 in antioxidant response and metabolic control and examine how reactive oxygen species, p53, and related cellular signaling may regulate NSC homeostasis, quiescence, and differentiation. We also discuss the role that PI3K-Akt-mTOR signaling plays in NSC biology and oxidative signaling and how p53 contributes to the regulation of this signaling cascade. Finally, we invite reflection on the several unanswered questions of the role that p53 plays in NSC biology and metabolism, anticipating future directions.
Laboratory for Neuroregeneration and Repair, Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany Laboratory for Neuroimmunology, Department of Vascular Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany kirsi.forsberg@medizin.uni-tuebingen.de s.di-giovanni@imperial.ac.uk.
Kirsi
K
Forsberg
Laboratory for Neuroregeneration and Repair, Department of Neurology, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany Molecular Neuroregeneration, Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK.
Simone
S
Di Giovanni
PI3K-Akt-mTOR signaling; ROS; antioxidant response; neural stem cells; p53