Supramolecular Polymers Formed by ABC Miktoarm Star Peptides.
We report here the design and synthesis of an ABC miktoarm star peptide connecting through a lysine junction a short peptide sequence and two hydrophobic but immiscible blocks (a hydrocarbon and a fluorocarbon). The designed molecule can self-assemble into one-dimensional nanostructures with a great diversity of kinetically evolving morphologies in aqueous solution, while molecules that contain only one of the two hydrophobic blocks form structurally similar filaments. We believe the rich assembly behavior and morphological evolution are a direct reflection of the molecular frustration present within the filament core as a result of the in-compatibility of the fluorocarbon and hydrocarbon segments. Our finding opens new opportunities for creating complex supramolecular polymers through the architecture design of small molecular building units.
Department of Chemical & Biomolecular Engineering and The Johns Hopkins University, Baltimore, Maryland 21218, United States ; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, Maryland 21218, United States.
Yi-An
YA
Lin
Department of Chemical & Biomolecular Engineering and The Johns Hopkins University, Baltimore, Maryland 21218, United States.
Yu-Chuan
YC
Ou
Department of Chemical & Biomolecular Engineering and The Johns Hopkins University, Baltimore, Maryland 21218, United States ; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, Maryland 21218, United States.
Andrew G
AG
Cheetham
Department of Chemical & Biomolecular Engineering and The Johns Hopkins University, Baltimore, Maryland 21218, United States ; Institute for NanoBioTechnology, The Johns Hopkins University, Baltimore, Maryland 21218, United States.
Honggang
H
Cui
amphiphilic peptides; fluorocarbons; self-assembly; supramolecular filaments