Role of Akt in human malignant glioma: from oncogenesis to tumor aggressiveness.
Gathering evidence has revealed that Akt signaling pathway plays an important role in glioma progression and aggressiveness. Among Akt kinases the most studied, Akt1, has been involved in many cellular processes that are in favor of cell malignancy. More recently, the actions of the two other isoforms, Akt2 and Akt3 have emerged in glioma. After a description of Akt pathway activation, we will explore the role of each isoform in malignant glioma that strengthens the current preclinical and clinical studies evaluating the impact of Akt pathway targeting in glioblastomas.
Clermont Université, Université d'Auvergne, EA7283 CREaT, 28 Place Henri Dunant, 63000, Clermont-Ferrand, France, emmanuel.chautard@cjp.fr.
Emmanuel
E
Chautard
Zangbéwendé Guy
ZG
Ouédraogo
Julian
J
Biau
Pierre
P
Verrelle
D063646:Carcinogenesis / Q000378:metabolism*; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm / Q000502:physiology; D004789:Enzyme Activation; D005910:Glioma / Q000201:enzymology* / Q000473:pathology*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D007527:Isoenzymes; D051057:Proto-Oncogene Proteins c-akt