Rewiring cancer cell death to enhance oncolytic viro-immunotherapy.
Oncolytic viruses are novel immunotherapeutic agents that appear to mediate potent antineoplastic effects in both preclinical and clinical settings. Recent studies demonstrate that manipulating the mechanisms whereby cancer cells die in the course of oncolytic virotherapy has potential to boost anticancer immune responses.
Department of Pathology and Molecular Medicine; McMaster Immunology Research Centre; Institute for Infectious Disease Research; McMaster University; Hamilton, ON Canada.
Samuel T
ST
Workenhe
Department of Pathology and Molecular Medicine; McMaster Immunology Research Centre; Institute for Infectious Disease Research; McMaster University; Hamilton, ON Canada.
Karen L
KL
Mossman
chemotherapy; danger-associated molecular patterns; immunogenic cell death; mitoxantrone; oncolytic virus