P2X4 receptors expressed on microglial cells in post-ischemic inflammation of brain ischemic injury.
Post-ischemic inflammation is an essential step in the progression of brain ischemia injury. P2X4 receptors are the predominant purinergic P2X receptor subtypes expressed on immune and neural cells. The subtype traffic between intracellular compartments and the plasma membrane form protein interactions with each other to regulate ATP-dependent signaling. The P2X4 receptors expressed on microglial cells have been reported to be involved in the inflammatory response of many central nervous system diseases. However, the mechanism that activates microglial cells and the role of P2X4 receptor expressed in microglial cells in the ischemic brain remains to be clarified. Here we provide a review for understanding and exploring converging lines of evidence for involvement of P2X4 receptors expressed on microglial cells in the post-ischemic inflammation in the brain ischemic injury.
Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China.
Rui-Dong
RD
Cheng
Department of Family Medicine, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China.
Jing-Jing
JJ
Ren
Department of Neurology, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Yan-Yan
YY
Zhang
Department of Rehabilitation Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, China. Electronic address: chruidong@gmail.com.
Xiang-Ming
XM
Ye
D002545:Brain Ischemia / Q000378:metabolism*; D006801:Humans; D017628:Microglia / Q000378:metabolism*; D058848:Receptors, Purinergic P2X4 / Q000378:metabolism*
D058848:Receptors, Purinergic P2X4
Brain ischemic injury; Microglial cells; P2X4 receptors; Post-ischemic inflammation