[Analysis of rational clinical uses of traditional Chinese medicine injections and factors influencing adverse drug reactions].
OBJECTIVE
To rationalize the clinical use and safety are some of the key issues in the surveillance of traditional Chinese medicine injections (TCMIs).


METHODS
In this 2011 study, 240 medical records of patients who had been discharged following treatment with TCMIs between 1 and 12 month previously were randomly selected from hospital records. Consistency between clinical use and the description of TCMIs was evaluated. Research on drug use and adverse drug reactions/events using logistic regression analysis was carried out.


RESULTS
There was poor consistency between clinical use and best practice advised in manuals on TCMIs. Over-dosage and overly concentrated administration of TCMIs occurred, with the outcome of modifying properties of the blood. Logistic regression analysis showed that, drug concentration was a valid predictor for both adverse drug reactions/events and benefits associated with TCMIs.


CONCLUSIONS
Surveillance of rational clinical use and safety of TCMIs finds that clinical use should be consistent with technical drug manual specifications, and drug use should draw on multi-layered logistic regression analysis research to help avoid adverse drug reactions/events.
Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Pharmacy, Shandong Provincial Hospital of Integrated Medicine, Jinan 250001, China. S.G.SUN@hotmail.com
Shi-Guang
SG
Sun
Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Pharmacy, Shandong Provincial Hospital of Integrated Medicine, Jinan 250001, China.
Zi-Feng
ZF
Li
Institute of Basic Research in Clinical Basis Medicine, China Academy of Chinese Medical Science, Beijing 100700, China.
Yan-Ming
YM
Xie
Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Pharmacy, Shandong Provincial Hospital of Integrated Medicine, Jinan 250001, China.
Jian
J
Liu
Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Pharmacy, Shandong Provincial Hospital of Integrated Medicine, Jinan 250001, China.
Yan
Y
Lu
Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Pharmacy, Shandong Provincial Hospital of Integrated Medicine, Jinan 250001, China.
Yi-Fei
YF
Song
Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Pharmacy, Shandong Provincial Hospital of Integrated Medicine, Jinan 250001, China.
Ying-Hua
YH
Han
Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Pharmacy, Shandong Provincial Hospital of Integrated Medicine, Jinan 250001, China.
Li-Da
LD
Liu
Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Department of Pharmacy, Shandong Provincial Hospital of Integrated Medicine, Jinan 250001, China.
Ting-Ting
TT
Peng
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D002986:Clinical Trials as Topic; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology* / Q000209:etiology; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
D004365:Drugs, Chinese Herbal