Mean platelet volume in children with attention deficit hyperactivity disorder.
The mean platelet volume (MPV), the accurate measure of platelet size, is considered a marker and determinant of platelet function. MPV can be a potentially useful prognostic biomarker in patients with cardiovascular disease. After reviewing literature, we hypothesized that attention deficit hyperactivity disorder (ADHD) in childhood may be a risk factor for coronary heart disease (CHD) in adulthood. The aim of this study was investigation of MPV and platelet count (PLT) in children with ADHD and healthy subjects. The MPV and the PLT were measured in 70 children with ADHD (aged 6-16 years), and compared with 41 healthy controls. The MPV was found to be significantly increased in ADHD group compared to control group (p=.006). There was no significant difference in the PLT between groups (p>.05). To our knowledge, this was the first study of investigating the levels of MPV and PLT in children with ADHD. Although significance and cause of increased MPV level in ADHD remain unclear in present study, further studies are warranted to investigate relationships among MPV, ADHD in childhood and CHD in adulthood.
Division of Child and Adolescent Psychiatry, Department of Child Development, Faculty of Health Science, Uskudar University, Istanbul, Turkey.
Ozgur
O
Yorbik
Department of Child and Adolescent Psychiatry, Bakirkoy Dr. Mazhar Osman Psychiatric and Neurological Diseases Teaching and Research Hospital, Istanbul, Turkey. Electronic address: canerrmutluu@yahoo.com.
Caner
C
Mutlu
Department of Pediatrics, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey.
Ilhan Asya
IA
Tanju
Department of Pediatrics, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey.
Dincer
D
Celik
Department of Biochemistry, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey.
Omer
O
Ozcan
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood*; D016022:Case-Control Studies; D002648:Child; D006801:Humans; D010976:Platelet Count