Calculation of the efficacy of vaccines against tick infestations on cattle.
Cattle ticks are responsible for great economic losses in cattle farming worldwide, and their main control method, chemicals, has been showing problems, whether resulting from the development of resistant strains of ticks or environmental contamination. Research studies directed toward developing vaccines against ticks are emerging. One way to evaluate those vaccines is to calculate the percentage of efficacy. The aim of this study was to analyze scientific publications archived in PubMed that used this method of assessment and discuss the main factors that may affect its calculation. Thus, 25 articles addressing this subject were selected. The percentage of efficacy was usually calculated in one of two ways, with one considering the reduced fertility of eggs and the other not. The latter method may underestimate the vaccine efficacy, and the most complete formula for calculating the efficacy reflects how much the vaccine actually affects the infestation. In our view, the use of the complete formula for calculating the percentage of efficacy is broader and more representative of the vaccine effect on the tick population.
Programa de Pós-graduação em Ciência Animal, Universidade Federal de Mato Grosso do Sul - UFMS, MS, Brasil, Programa de Pós-graduação em Ciência Animal, Universidade Federal de Mato Grosso do Sul - UFMS, MS, Brasil.
Rodrigo Casquero
RC
Cunha
Departamento de Sanidade Animal, Embrapa Gado de Corte, Empresa Brasileira de Pesquisa Agropecuária - EMBRAPA, Campo GrandeMS, Brasil, Departamento de Sanidade Animal, Embrapa Gado de Corte, Empresa Brasileira de Pesquisa Agropecuária - EMBRAPA, Campo Grande, MS, Brasil.
Renato
R
Andreotti
Departamento de Sanidade Animal, Embrapa Gado de Corte, Empresa Brasileira de Pesquisa Agropecuária - EMBRAPA, Campo GrandeMS, Brasil, Departamento de Sanidade Animal, Embrapa Gado de Corte, Empresa Brasileira de Pesquisa Agropecuária - EMBRAPA, Campo Grande, MS, Brasil.
Marcos Valério
MV
Garcia
Programa de Pós-graduação em Ciência Animal, Universidade Federal de Mato Grosso do Sul - UFMS, MS, Brasil, Programa de Pós-graduação em Ciência Animal, Universidade Federal de Mato Grosso do Sul - UFMS, MS, Brasil.
André de Abreu Rangel
Ade A
Aguirre
Instituto de Investigação Científica Tropical - IICT, Centro de Investigação Interdisciplinar em Sanidade Animal - CIISA, Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa - UTL, Lisboa, Portugal, Instituto de Investigação Científica Tropical - IICT, Centro de Investigação Interdisciplinar em Sanidade Animal - CIISA, Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa - UTL, Lisboa, Portugal.
Alexandre
A
Leitão
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000469:parasitology* / Q000517:prevention & control*; D013984:Tick Infestations / Q000517:prevention & control / Q000662:veterinary*; D016896:Treatment Outcome; D014611:Vaccination / Q000706:statistics & numerical data*; D014612:Vaccines
D014612:Vaccines