Highly selective and controllable synthesis of arylhydroxylamines by the reduction of nitroarenes with an electron-withdrawing group using a new nitroreductase BaNTR1.
A new bacterial nitroreductase has been identified and used as a biocatalyst for the controllable reduction of a variety of nitroarenes with an electron-withdrawing group to the corresponding N-arylhydroxylamines under mild reaction conditions with excellent selectivity (>99%). This method therefore represents a green and efficient method for the synthesis of arylhydroxylamines.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. gaoweizheng@ecust.edu.cn jianhexu@ecust.edu.cn.
Hieu-Huy
HH
Nguyen-Tran
Gao-Wei
GW
Zheng
Xu-Hong
XH
Qian
Jian-He
JH
Xu
D001407:Bacillus / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D055162:Biocatalysis; D055772:Green Chemistry Technology; D006898:Hydroxylamines / Q000138:chemical synthesis*; D009574:Nitro Compounds / Q000737:chemistry*; D009601:Nitroreductases / Q000737:chemistry* / Q000378:metabolism; D010084:Oxidation-Reduction
D001426:Bacterial Proteins; D006898:Hydroxylamines; D009574:Nitro Compounds; D009601:Nitroreductases