Surgical complications and graft function following live-donor extraperitoneal renal transplantation in children 20 kg or less.
OBJECTIVE
To evaluate the effect of patient, surgical, and medical factors on surgical complications and graft function following renal transplantation (Tx) in children weighing ≤ 20 kg, because the number of this challenging group of children is increasing.


METHODS
Between June 2009 and October 2013, 26 patients received living donor renal allotransplant using the extraperitoneal approach (EPA). The immunosuppression regimen was composed of prednisolone, mycophenolate mofetil, and ciclosporin or tacrolimus.


RESULTS
The mean weight was 16.46 ± 2.61 kg. Mean cold ischemia time was 53.85 ± 12.35 min. The graft survival rate (GSR) and patient survival rate (PSR) were 96% at 3 years. Acute rejection episodes (AREs) occurred in eight patients (30%). Postoperative surgical complications were ureteral leakage (3), vesicoureteric reflux (2), and renal vein thrombosis (2) (with one graft nephrectomy). Mean follow-up was 37.5 ± 7.4 months.


CONCLUSIONS
Excellent PSR and GSR can be achieved in low weight (<20 kg) recipients. Even in very low weight patients, the EPA was used. No cases were reported with primary graft non-function due to use of living donors, increasing pre-Tx body weight to at least 10 kg and maintaining adequate filling pressure before graft reperfusion. The presence of related donors and use of induction therapy and tacrolimus decreased the rate of ARE while the presence of pre-Tx lower urinary tract surgical interventions increased the rate of ureteric complications, but this was statistically insignificant.
Division of Pediatric Urology, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt. Electronic address: mohammedshemy@yahoo.com.
Mohammed S
MS
ElSheemy
Division of Pediatric Urology, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt.
Ahmed M
AM
Shouman
Division of Pediatric Urology, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt.
Ahmed I
AI
Shoukry
Division of Pediatric Anesthesia, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt.
Sherif
S
Soaida
Division of Pediatric Nephrology, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt.
Doaa M
DM
Salah
Division of Pediatric Urology, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt.
Ali M
AM
Yousef
Division of Pediatric Urology, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt.
Hany A
HA
Morsi
Division of Pediatric Nephrology, Aboul-Riche Children's Hospital, Cairo University, Cairo, Egypt.
Fatina I
FI
Fadel
Urology Department, Kasr Al-Ainy Hospital, Cairo University, Cairo, Egypt.
Sameh Z
SZ
Sadek
D000328:Adult; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology*; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015996:Survival Rate; D016896:Treatment Outcome
Extraperitoneal approach; Live donor; Low body weight children; Pediatric; Renal transplantation