The effect of bumetanide treatment on the sensory behaviours of a young girl with Asperger syndrome.
Sensory behaviours were not considered as core features of autism spectrum disorders until recently. However, they constitute an important part of the observed symptoms that result in social maladjustment and are currently quite difficult to treat. One promising strategy for the treatment of these behaviours is the use of bumetanide, which was previously shown to reduce the severity of autism spectrum disorders. In this study, we proposed to evaluate sensory behaviours using Dunn's Sensory Profile after 18 months of bumetanide treatment in a 10-year-old girl with Asperger syndrome. Reported improvements covered a large range of sensory behaviours, including auditory, vestibular, tactile, multisensory and oral sensory processing. Although our results were limited to a single case report, we believe that our clinical observations warrant clinical trials to test the long-term efficacy of bumetanide to manage the sensory behaviours of people with autism spectrum disorders.
CHRU Brest, Centre de Ressources Autisme, Bohars, France.
Marine
M
Grandgeorge
Eric
E
Lemonnier
Céline
C
Degrez
Nelle
N
Jallot
D020817:Asperger Syndrome / Q000188:drug therapy*; D002034:Bumetanide / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
D049994:Sodium Potassium Chloride Symporter Inhibitors; D002034:Bumetanide