[Effect of pituitary tumour transforming gene on invasion and metastasis of salivary adenoid cystic carcinoma].
OBJECTIVE
To study the effect of pituitary tumour transforming gene (PTTG) on invasion and metastasis of salivary adenoid cystic carcinoma.


METHODS
The expression of PTTG and bFGF was investigated in 40 salivary adenoid cystic carcinoma tissues and 20 normal salivary tissues by immunohistochemistry. Pearson's Chi-square test and Spearman correlation analysis were used to analyze the data using SPSS 11.5 software package.


RESULTS
The expression of PTTG and bFGF were significantly higher in salivary adenoid cystic carcinoma tissues than in normal salivary gland tissues (P<0.01) and their expression levels were positively correlated (P<0.01).


CONCLUSIONS
PTTG and bFGF are highly expressed in salivary adenoid cystic carcinoma. The invasion and metastasis of salivary adenoid cystic carcinoma are correlated with the expression of PTTG. Supported by National Natural Science Foundation of China (81102058).
Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University. Shenyang 110002;China. E-mail:daqi00001@sina.com.
Zhong-zheng
ZZ
Qi
Jie
J
Liu
Fa-yu
FY
Liu
Chang-fu
CF
Sun
D003528:Carcinoma, Adenoid Cystic; D006801:Humans; D007150:Immunohistochemistry; D010911:Pituitary Neoplasms; D012468:Salivary Gland Neoplasms; D064249:Securin
D064249:Securin; C578002:pituitary tumor-transforming protein 1, human