Two new neoclerodane diterpenoids from Scutellaria barbata D. Don growing in Vietnam.
Various chromatographic separations of the aerial parts of Scutellaria barbata afforded two new neoclerodane diterpenoids, scutebatas S and T (1 and 2), along with scutebata D (3). Their structures were elucidated by spectroscopic methods including high-resolution electrospray ionization mass spectrometry, 1D and 2D NMR and comparison with the literature values. Compounds 1 and 3 exhibited moderate cytotoxic activities against HL-60 (promyeloblast) human cancer cells. Weak cytotoxic effects toward four tested human cancer cell lines including KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), MCF7 (breast cancer), and Hep-G2 (hepatoma cancer) were observed for 1 and 3; whereas 2 was inactive on all five tested cell lines.
a Institute of Biotechnology (IBT), Vietnam Academy of Science and Technology (VAST) , 18 Hoang Quoc Viet road, Caugiay , Hanoi , Viet Nam.
Do Thi
do T
Thao
Do Thi
do T
Phuong
Tran Thi Hong
TT
Hanh
Nguyen Phuong
NP
Thao
Nguyen Xuan
NX
Cuong
Nguyen Hoai
NH
Nam
Chau Van
CV
Minh
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D018922:HL-60 Cells; D056945:Hep G2 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D031363:Scutellaria / Q000737:chemistry*; D014744:Vietnam
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane; C468586:neoclerodane; C000588507:scutebata S; C000588508:scutebata T