Modifying tumor-associated macrophages: An important adjunct to immunotherapy.
The therapeutic success of immunotherapy requires specific alterations of the tumor microenvironment and/or the inhibition of tumor-elicited immunosuppression. Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment. We have recently shown that modulating TAMs dramatically augments the efficacy of immunotherapy. TAM-activating agents should hence be considered as an addition to immunotherapy in future clinical trials.
Institute of Pulmonary Medicine; Hadassah-Hebrew University Medical Center; Jerusalem, Israel ; Thoracic Oncology Laboratory; University of Pennsylvania; Philadelphia, PA USA.
Zvi G
ZG
Fridlender
Thoracic Oncology Laboratory; University of Pennsylvania; Philadelphia, PA USA.
Steven M
SM
Albelda
DMXAA; immunotherapy; lung cancer; tumor associated macrophages; vaccines