Descriptive analysis of and overall survival after surgical treatment of lung metastases.
OBJECTIVE
To describe demographic characteristics, surgical results, postoperative complications, and overall survival rates in surgically treated patients with lung metastases.


METHODS
This was a retrospective analysis of 119 patients who underwent a total of 154 lung metastasis resections between 1997 and 2011.


RESULTS
Among the 119 patients, 68 (57.1%) were male and 108 (90.8%) were White. The median age was 52 years (range, 15-75 years). In this sample, 63 patients (52.9%) presented with comorbidities, the most common being systemic arterial hypertension (69.8%) and diabetes (19.0%). Primary colorectal tumors (47.9%) and musculoskeletal tumors (21.8%) were the main sites of origin of the metastases. Approximately 24% of the patients underwent more than one resection of the lesions, and 71% had adjuvant treatment prior to metastasectomy. The rate of lung metastasis recurrence was 19.3%, and the median disease-free interval was 23 months. The main surgical access used was thoracotomy (78%), and the most common approach was wedge resection with segmentectomy (51%). The rate of postoperative complications was 22%, and perioperative mortality was 1.9%. The overall survival rates at 12, 36, 60, and 120 months were 96%, 77%, 56%, and 39%, respectively. A Cox analysis confirmed that complications within the first 30 postoperative days were associated with poor prognosis (hazard ratio = 1.81; 95% CI: 1.09-3.06; p = 0.02).


CONCLUSIONS
Surgical treatment of lung metastases is safe and effective, with good overall survival, especially in patients with fewer metastases.
State University at Campinas, Hospital de Clínicas, Campinas, Brazil.
Giana Balestro
GB
Poletti
State University at Campinas, School of Medical Sciences, Campinas, Brazil.
Ivan Felizardo Contrera
IF
Toro
State University at Campinas, School of Medical Sciences, Campinas, Brazil.
Thais Ferreira
TF
Alves
State University at Campinas, School of Medical Sciences, Campinas, Brazil.
Eliana Cristina Martins
EC
Miranda
State University at Campinas, School of Medical Sciences, Campinas, Brazil.
José Cláudio Teixeira
JC
Seabra
State University at Campinas, School of Medical Sciences, Campinas, Brazil.
Ricardo Kalaf
RK
Mussi
D000293:Adolescent; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007902:Length of Stay; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012509:Sarcoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult