Prefilled devices for parenteral applications.
Current parenteral administration of drugs suffers from several drawbacks including the requirement of healthcare personnel to administer the drug, the risk of needle stick injuries that may result in the transmission of blood borne pathogens, and patient discomfort. Prefilled devices have emerged as powerful tools to improve parenteral administration of drugs. There are a number of clinical conditions including treatment of endocrine diseases, neurological disorders, autoimmune diseases and emergency medicine where prefilled devices have made major improvements to patient care. Prefilled devices have become an important set of tools for the medical practitioner due to their ease of use and safety, cost effectiveness and patient convenience. This review provides a comprehensive summary of existing prefilled devices, their current clinical uses and corresponding regulatory processes.
Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, 500 Technology Square, NE47-525, Cambridge, MA 02139, USA.
Pablo
P
Gurman
Albert
A
Chi
Tiffany
T
Hood
Micaela
M
Reina
Yitzhak
Y
Rosen
Sebastian
S
D'hers
Noel
N
Elman
D006801:Humans; D007263:Infusions, Parenteral / Q000295:instrumentation*; D010353:Patient Education as Topic; D012926:Social Control, Formal; D014481:United States; D014486:United States Food and Drug Administration