Future prospects for tissue engineered lung transplantation: decellularization and recellularization-based whole lung regeneration.
The shortage of donor lungs for transplantation causes a significant number of patient deaths. The availability of laboratory engineered, functional organs would be a major advance in meeting the demand for organs for transplantation. The accumulation of information on biological scaffolds and an increased understanding of stem/progenitor cell behavior has led to the idea of generating transplantable organs by decellularizing an organ and recellularizing using appropriate cells. Recellularized solid organs can perform organ-specific functions for short periods of time, which indicates the potential for the clinical use of engineered solid organs in the future.   The present review provides an overview of progress and recent knowledge about decellularization and recellularization-based approaches for generating tissue engineered lungs. Methods to improve decellularization, maturation of recellularized lung, candidate species for transplantation and future prospects of lung bioengineering are also discussed.
Division of Surgical Oncology; Department of Surgery; Nagasaki University Graduate School of Biomedical Sciences; Nagasaki, Japan.
Tomoshi
T
Tsuchiya
Departments of Anesthesia and Biomedical Engineering; Yale University; New Haven, CT USA.
Amogh
A
Sivarapatna
Departments of Anesthesia and Biomedical Engineering; Yale University; New Haven, CT USA.
Kevin
K
Rocco
Division of Surgical Oncology; Department of Surgery; Nagasaki University Graduate School of Biomedical Sciences; Nagasaki, Japan.
Atsushi
A
Nanashima
Division of Surgical Oncology; Department of Surgery; Nagasaki University Graduate School of Biomedical Sciences; Nagasaki, Japan.
Takeshi
T
Nagayasu
Departments of Anesthesia and Biomedical Engineering; Yale University; New Haven, CT USA.
Laura E
LE
Niklason
D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000378:metabolism; D016040:Lung Transplantation; D012038:Regeneration; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
decellularization; extracellular matrix; induced pluripotent stem cells; lung transplantation; recellularization; stem/progenitor cells