Variants of papillary thyroid carcinoma: association with histopathological prognostic factors.
Papillary carcinoma is the most common thyroid malignancy. Many variants of this tumor have been described, with different morphological and molecular characteristics. Although most cases have excellent prognosis, the relationship between tumor architecture and its biological behavior remains controversial.


OBJECTIVE
To present the experience of a single center on the prevalence of thyroid papillary carcinoma variants and their relationship with other histopathological prognostic factors.


METHODS
Retrospective study of all the cases submitted to thyroidectomy for papillary carcinoma in the same institution over 11 years.


RESULTS
We included 517 patients, 81.9% of them were women. The average age was 47.2 years. The variants recognized to have higher aggressiveness potential corresponded to 5.6% of the sample. We found an association of tumor subtypes with greater lesion diameter, T staging, lymphovascular and gland capsule invasion.


CONCLUSIONS
A small percentage of papillary carcinoma cases is represented by variants recognized by their greater potential for aggression. There are associations between these variants and several other histopathological factors already recognized for their prognostic value, which may, by themselves, influence the outcome of these cases.
Irmandade Santa Casa de Misericórdia de Porto Alegre, Hospital Santa Rita, equipe de cirurgia de cabeça e pescoço.
Fábio Muradás
FM
Girardi
Irmandade Santa Casa de Misericórdia de Porto Alegre, Departamento de Patologia.
Marinez Bizarro
MB
Barra
Irmandade Santa Casa de Misericórdia de Porto Alegre, Departamento de Patologia.
Cláudio Galleano
CG
Zettler
D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy; D055815:Young Adult