Interleukin-23 receptor single nucleotide polymorphisms in ulcerative colitis. A study in Iranian populations.
OBJECTIVE
Genetic factors seem to play an important role in the pathogenesis of ulcerative colitis (UC). Genome wide association studies showed a highly significant association between interleukin 23 receptor (IL23R) single nucleotide polymorphisms (SNPs) and Crohn's disease; however, there are contrary results regarding the disease-modifying effects of IL23R variants in UC. This study was performed in a group of patients with UC to test the possible role of IL23R SNPs in conferring susceptibility or protection against the disease.


METHODS
The study was performed on 67 Iranian adult patients with UC and 78 healthy controls. Eight IL23R SNPs were genotyped, using real-time polymerase chain reaction (RT-PCR). The frequencies of alleles and genotype at each position were determined and compared between two groups of patients and controls.


RESULTS
The frequency of the T allele at position rs1343151 was significantly higher in the patient group, compared to the controls (P=0.018). The TT genotype at the same position was also significantly overrepresented in the patient group (P=0.02). There was no significant difference in alleles and genotype frequencies of other SNPs between patients and controls.


CONCLUSIONS
This study identified a new susceptibility locus associated with UC. Our findings provide further insight into the genetics of UC, which might be amenable to future therapeutic intervention.
Department of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran.
Nasser
N
Ebrahimi Daryani
Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Farnaz
F
Najmi Varzaneh
Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Mona
M
Hedayat
Department of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad
M
Taher
Department of Gastroenterology and Hepatology, Tehran University of Medical Sciences, Tehran, Iran; Hematology Department, School of Allied Medical Science, Tehran University of Medical Sciences, Tehran, Iran.
Elham
E
Farhadi
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Mahdi
M
Mahmoudi
Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Hossein
MH
Nicknam
Gastrointestinal Research Group, University of Calgary, Calgary, AB, Canada.
Mohammad
M
Bashashati
Molecular Immunology Research Center, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: rezaei_nima@tums.ac.ir.
Nima
N
Rezaei
D000328:Adult; D016022:Case-Control Studies; D003093:Colitis, Ulcerative / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053759:Interleukin-23 / Q000235:genetics*; D007492:Iran / Q000453:epidemiology; D008297:Male; D020641:Polymorphism, Single Nucleotide
D053759:Interleukin-23