Hard tick factors implicated in pathogen transmission.
Ticks are the most common arthropod vector, after mosquitoes, and are capable of transmitting the greatest variety of pathogens. For both humans and animals, the worldwide emergence or re-emergence of tick-borne disease is becoming increasingly problematic. Despite being such an important issue, our knowledge of pathogen transmission by ticks is incomplete. Several recent studies, reviewed here, have reported that the expression of some tick factors can be modulated in response to pathogen infection, and that some of these factors can impact on the pathogenic life cycle. Delineating the specific tick factors required for tick-borne pathogen transmission should lead to new strategies in the disruption of pathogen life cycles to combat emerging tick-borne disease.
USC INRA Bartonella-tiques, UMR BIPAR ENVA-ANSES, Maisons-Alfort, France.
Xiang Ye
XY
Liu
USC INRA Bartonella-tiques, UMR BIPAR ENVA-ANSES, Maisons-Alfort, France.
Sarah I
SI
Bonnet
D000818:Animals; D001096:Arachnid Vectors / Q000382:microbiology* / Q000469:parasitology* / Q000502:physiology; D018562:Disease Transmission, Infectious; D006801:Humans; D026863:Ixodidae / Q000382:microbiology* / Q000469:parasitology* / Q000502:physiology; D017282:Tick-Borne Diseases / Q000453:epidemiology*