Effects of the intragastric balloon MedSil on weight loss, fat tissue, lipid metabolism, and hormones involved in energy balance.
BACKGROUND
The prevalence of obesity continues to increase worldwide. Because obesity is associated with a number health-related problems as well as a shortened life span, treating obesity is an important clinical concern. Although various treatments are currently available, many are not efficacious in the long term. Therefore, additional medical treatment options for morbidly obese individuals must be explored. In this study, we examined the effects of the intragastric balloon MedSil on anthropometric measures and hormones associated with lipid and energy metabolism.


METHODS
Twenty-two obese patients underwent insertion of the intragastric balloon MedSil following a clinical exam, body composition scan, and collection of blood samples. Six months following implantation of the balloon, additional anthropometric and serological measures were taken.


RESULTS
Six months following insertion of the MedSil balloon, we observed significant decreases in body weight, body mass index, and fat mass. Compared with baseline levels, ghrelin serum levels were increased significantly, while leptin, FGF21, and glycated hemoglobin levels significantly decreased, 6 months after balloon insertion.


CONCLUSIONS
The MedSil intragastric balloon is a safe and effective treatment for morbid obesity, with positive effects on anthropometric measures and lipid metabolism.
Department of Physiology and Pathophysiology, Faculty of Medicine, University of Ostrava, Syllabova 19, Ostrava, 703 00, Czech Republic, marek.buzga@osu.cz.
Marek
M
Bužga
Machytka
M
Evžen
Klvaňa
K
Pavel
Kupka
K
Tomáš
Zavadilová
Z
Vladislava
Zonča
Z
Pavel
Zdeněk
Z
Svagera
D054392:Adipokines / Q000097:blood; D000328:Adult; D042682:Angiopoietins / Q000097:blood; D001823:Body Composition; D015992:Body Mass Index; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood; D005500:Follow-Up Studies; D015905:Gastric Balloon; D054439:Ghrelin / Q000097:blood; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery*; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*; D055815:Young Adult
D054392:Adipokines; D042682:Angiopoietins; D054439:Ghrelin; D005346:Fibroblast Growth Factors