Periostin is upregulated in coronary arteriopathy in Kawasaki disease and is a potential diagnostic biomarker.
Periostin was upregulated 11-fold in acute and chronic Kawasaki disease coronary arteries compared with controls (P = 0.003). Kawasaki disease patients had significantly elevated serum periostin values compared with febrile controls (P = 0.0086). There was no relationship between serum periostin values and age, gender or acute phase reactants; there was a relationship between serum periostin and maximal coronary artery Z scores that did not reach significance (P = 0.08). Periostin may prove to be useful as a component of a future diagnostic biomarker panel for Kawasaki Disease.
From the *Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago; †Department of Preventive Medicine, Northwestern University Feinberg School of Medicine; ‡Department of Microbiology/Immunology, Loyola University Stritch School of Medicine, Maywood; §Department of Pathology, Northwestern University Feinberg School of Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago; ¶Department of Pathology, University of Chicago Pritzker School of Medicine; and ‖Department of Pathology and Laboratory Medicine, Alberta Children's Hospital, Calgary, Alberta, Canada.
Rebecca
R
Reindel
Kwang-Youn A
KY
Kim
Susan C
SC
Baker
Stanford T
ST
Shulman
Elizabeth J
EJ
Perlman
Mark W
MW
Lingen
Cynthia
C
Trevenen
Anne H
AH
Rowley
D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D002675:Child, Preschool; D015331:Cohort Studies; D003331:Coronary Vessels / Q000737:chemistry; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000378:metabolism*; D012313:RNA / Q000032:analysis; D015854:Up-Regulation
D015415:Biomarkers; D015815:Cell Adhesion Molecules; C512835:POSTN protein, human; D012313:RNA