Tritium labeling of detonation nanodiamonds.
For the first time, the radioactive labeling of detonation nanodiamonds was efficiently achieved using a tritium microwave plasma. According to our measurements, the total radioactivity reaches 9120 ± 120 μCi mg(-1), with 93% of (3)H atoms tightly bonded to the surface and up to 7% embedded into the diamond core. Such (3)H doping will ensure highly stable radiolabeled nanodiamonds, on which surface functionalization is still allowed. This breakthrough opens the way to biodistribution and pharmacokinetics studies of nanodiamonds, while this approach can be scalable to easily treat bulk quantities of nanodiamonds at low cost.
CEA, LIST, Diamond Sensors Laboratory, F-91191 Gif-sur-Yvette, France. jean-charles.arnault@cea.fr.
Hugues A
HA
Girard
Abdelouahab
A
El-Kharbachi
Sébastien
S
Garcia-Argote
Tristan
T
Petit
Philippe
P
Bergonzo
Bernard
B
Rousseau
Jean-Charles
JC
Arnault
D007553:Isotope Labeling; D008872:Microwaves; D058612:Nanodiamonds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D014316:Tritium / Q000737:chemistry*
D058612:Nanodiamonds; D014316:Tritium