MiR-22 suppresses the proliferation and invasion of gastric cancer cells by inhibiting CD151.
Gastric cancer (GC) is the second common cause of cancer-related death worldwide. microRNAs (miRNAs) play important roles in the carcinogenesis of GC. Here, we found that miR-22 was significantly decreased in GC tissue samples and cell lines. Ectopic overexpression of miR-22 remarkably suppressed cell proliferation and colony formation of GC cells. Moreover, overexpression of miR-22 significantly suppressed migration and invasion of GC cells. CD151 was found to be a target of miR-22. Furthermore, overexpression of CD151 significantly attenuated the tumor suppressive effect of miR-22. Taken together, miR-22 might suppress GC cells growth and motility partially by inhibiting CD151.
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Xun
X
Wang
Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: honggang_yuwh@163.com.
Honggang
H
Yu
Department of Gastroenterology, Wuchang Hospital of Wuhan City, Wuhan 430063, China.
Xinyao
X
Lu
Department of Gastroenterology, Wuchang Hospital of Wuhan City, Wuhan 430063, China.
Peng
P
Zhang
Department of Gastroenterology, Wuchang Hospital of Wuhan City, Wuhan 430063, China.
Minglin
M
Wang
Department of Neurology, Pu Ai Hospital of Wuhan City, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430034, China.
Yikui
Y
Hu
D020413:3' Untranslated Regions / Q000235:genetics; D001483:Base Sequence; D015153:Blotting, Western; D002460:Cell Line; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics*; D049109:Cell Proliferation; D002470:Cell Survival / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D057809:HEK293 Cells; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D009361:Neoplasm Invasiveness; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012689:Sequence Homology, Nucleic Acid; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D060185:Tetraspanin 24 / Q000235:genetics* / Q000378:metabolism; D014162:Transfection
D020413:3' Untranslated Regions; C554715:CD151 protein, human; C548375:MIRN22 microRNA, human; D035683:MicroRNAs; D060185:Tetraspanin 24
CD151; Gastric cancer; Invasion; Migration; Proliferation; miR-22