Altered brain activation during response inhibition and error processing in subjects with Internet gaming disorder: a functional magnetic imaging study.
The aim of the present study was to evaluate the impulsivity and brain correlates of response inhibition and error processing among subjects with Internet gaming disorder (IGD). We evaluated the response inhibition and error processing by functional magnetic resonance imaging (fMRI) in subjects with IGD and controls. Twenty-six men with IGD for at least 2 years and 23 controls with no history of IGD were recruited as the IGD and control groups, respectively. All subjects performed the event-related designed Go/No-go task under fMRI and completed questionnaires related to Internet addiction and impulsivity. The IGD group exhibited a higher score for impulsivity than the control group. The IGD group also exhibited higher brain activation when processing response inhibition over the left orbital frontal lobe and bilateral caudate nucleus than controls. Both the IGD and control groups exhibited activation of the insula and anterior cingulate cortex during error processing. The activation over the right insula was lower in the subjects with IGD than the control group. Our results support the fact that the fronto-striatal network involved in response inhibition, and the salience network, anchored by the anterior cingulate and insula, contributes to error processing. Further, adults with IGD have impaired insular function in error processing and greater activation of the fronto-striatal network in order to maintain their response inhibition performance.
Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chih-Hung
CH
Ko
Tsyh-Jyi
TJ
Hsieh
Chiao-Yun
CY
Chen
Cheng-Fang
CF
Yen
Cheng-Sheng
CS
Chen
Ju-Yu
JY
Yen
Peng-Wei
PW
Wang
Gin-Chung
GC
Liu
D000328:Adult; D016739:Behavior, Addictive / Q000503:physiopathology*; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D056344:Executive Function / Q000502:physiology*; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D007175:Impulsive Behavior / Q000502:physiology*; D007266:Inhibition, Psychological; D020407:Internet; D008279:Magnetic Resonance Imaging; D008297:Male; D018910:Video Games; D055815:Young Adult