[Correlation between dissolution in vitro and absorption in vivo of chuanping sustained release tablets].
OBJECTIVE
To investigate the correlation between dissolution in vitro and absorption in vivo of Chuanping sustained release tablets.


METHODS
The ephedrine, pseudoephedrine were chosen as marker components, dissolution in vitro of Chuanping sustained release tablets in the different pH were tested by the rotating basket method and HPLC; urine drug levels were determined by HPLC and absorption fractions were calculated according to Wagner-Nelson's formula and deconvolution technique.


RESULTS
The linear regressive equation between the absorption percentage in vivo F and accumulative release percentage in vitro of Chuanping sustained release tablets was established as F(ephedrine) = 1.572 5f-20. 729 (R2 = 0.974 5); F(pseudoephedrine) = 1.237f-0.147 6 (R2 = 0.959 5).


CONCLUSIONS
The results suggested that there was fine correlation between the absorption percentage in vivo and the accumulative release percentage in vitro of Chuanping sustained release tablets.
Institute of Traditional Chinese Medicine Development, Guangdong Pharmacological University, Guangzhou 510006, China. ayu19860524@163.com
Yan-Qu
YQ
Cai
Hubei University of Science and Technology, Xianning 437100, China.
Zhi-Peng
ZP
Zhang
Institute of Traditional Chinese Medicine Development, Guangdong Pharmacological University, Guangzhou 510006, China.
Yan-Hong
YH
Wu
Institute of Traditional Chinese Medicine Development, Guangdong Pharmacological University, Guangzhou 510006, China.
Jing
J
Liu
Institute of Traditional Chinese Medicine Development, Guangdong Pharmacological University, Guangzhou 510006, China.
Ji-Fu
JF
Xie
Institute of Traditional Chinese Medicine Development, Guangdong Pharmacological University, Guangzhou 510006, China.
Jin-Zhen
JZ
Chai
Institute of Traditional Chinese Medicine Development, Guangdong Pharmacological University, Guangzhou 510006, China.
Yu
Y
Luo
Institute of Traditional Chinese Medicine Development, Guangdong Pharmacological University, Guangzhou 510006, China.
Sheng-Shan
SS
Zhu
D000328:Adult; D002851:Chromatography, High Pressure Liquid; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004809:Ephedrine / Q000008:administration & dosage / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D012995:Solubility; D013607:Tablets / Q000737:chemistry; D055815:Young Adult
D003692:Delayed-Action Preparations; D004365:Drugs, Chinese Herbal; D013607:Tablets; D004809:Ephedrine