TiME for TMEM106B.
TMEM106B variants are genetically associated with frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), and are considered a major risk factor for this disease. As TMEM106B may be involved in other pathologies such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), uncovering its cellular functions has become a priority. In this issue of The EMBO Journal, Schwenk et al (2014) combine loss-of-function experiments, live imaging and proteomics to unveil the physiological roles played by TMEM106B and its binding partner MAP6 in lysosomal function and transport.
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology University College London, Queen Square, London, WC1N 3BG, UK.
Solène
S
Debaisieux
Giampietro
G
Schiavo
D000818:Animals; D003712:Dendrites / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*
C491894:MAP6 protein, human; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; C556915:TMEM106B protein, human