Association between phase angle, anthropometric measurements, and lipid profile in HCV-infected patients.
OBJECTIVE
The objective of this study was to investigate the associations between phase angle, anthropometric measurements, and lipid profile in patients chronically infected with the hepatitis C virus.


METHODS
A total of 160 consecutive patients chronically infected with the hepatitis C virus and who received treatment at the hepatitis C outpatient unit of our hospital from April 2010 to May 2011 were prospectively evaluated. Bioelectrical impedance analysis, anthropometric measurements, and serum lipid profile analysis were performed.


RESULTS
Twenty-five patients were excluded. A total of 135 patients with a mean age of 49.8±11.4 years were studied. Among these patients, 60% were male. The phase angle and BMI means were 6.5±0.8° and 26.5±4.8 kg/m2, respectively. Regarding anthropometric variables, mid-arm circumference, mid-arm muscle circumference, and arm muscle area had a positive correlation with phase angle. In contrast, when analyzing the lipid profile, only HDL was inversely correlated with phase angle. However, in multiple regression models adjusted for age and gender, only mid-arm circumference (p = 0.005), mid-arm muscle circumference (p = 0.003), and arm muscle circumference (p = 0.001) were associated with phase angle in hepatitis C virus-infected patients.


CONCLUSIONS
In conclusion, phase angle is positively correlated with anthropometric measures in our study. However, there is no association between phase angle and lipid profile in these patients. Our results suggest that phase angle is related to lean body mass in patients chronically infected with hepatitis C virus.
Department of Internal Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, BotucatuSP, Brazil.
Mariana de Souza
Mde S
Dorna
Department of Internal Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, BotucatuSP, Brazil.
Nara Aline
NA
Costa
School of Medicine, Federal University of Uberlandia, UberlandiaMG, Brazil.
Erick Prado de
EP
Oliveira
Department of Internal Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, BotucatuSP, Brazil.
Ligia Yukie
LY
Sassaki
Department of Internal Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, BotucatuSP, Brazil.
Fernando Gomes
FG
Romeiro
Department of Internal Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, BotucatuSP, Brazil.
Sergio Alberto Rupp de
SA
Paiva
Department of Internal Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, BotucatuSP, Brazil.
Marcos Ferreira
MF
Minicucci
Department of Internal Medicine, Universidade Estadual Paulista Júlio de Mesquita Filho, BotucatuSP, Brazil.
Giovanni Faria
GF
Silva
D000328:Adult; D000886:Anthropometry; D001823:Body Composition; D017097:Electric Impedance; D005260:Female; D016174:Hepacivirus; D019698:Hepatitis C, Chronic / Q000503:physiopathology*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D011446:Prospective Studies; D012016:Reference Values; D018709:Statistics, Nonparametric
D008055:Lipids