Serum uric acid level and cardiovascular risks in hemodialysis patients: an Algerian cohort study.
Elevated Serum Uric Acid (SUA) was usually associated with an increased risk of cardiovascular events and mortality in general population. However, there are few reports concerning the clinical impact and the pathogenic role of Uric Acid (UA) in Hemodialysis (HD) patients. The aim of the study was to investigate the relationship between SUA and various Cardiovascular (CV) risk factors in HD patients. This retrospective; observational cohort study includes 45 HD patients with a mean age of 51.26+/-15.21 years. The differences of the CV risk factors between the patients according to their SUA levels were investigated. Age, Cardiovascular Diseases (CVD), increased creatinine, Fasting Blood Glucose (FBG), Corrected Calcium (cCa), Phosphate (P), cCa x P product and LDL cholesterol levels were associated with lower SUA levels, whereas higher SUA level was associated with Diabetes Mellitus (DM), hypertension and increased triglycerides level (p<0.01). In multiple regression analysis, history of diabetes (beta= 0.360, p<0.05), reduced corrected serum calcium (cCa) (beta = -1.456, p<0.01) and Phosphate (P) levels (beta= -1.752, p<0.01) were predictive of an increased SUA concentration. Despite from what has been demonstrated in the general population and DM patients, a lower SUA level in HD patients was associated with higher cardiovascular risk factors and high co-morbidity burden. Moreover, higher SUA concentrations may be cardioprotective in dialysis patients.
Laboratory of Medical Biochemistry, IBN ZOHR Hospital, Guelma 24000, Algeria
Adel
A
Gouri
Department of Internal Medicine and cardiology, EL OKBI Hospital, Guelma 24000, Algeria
Aoulia
A
Dekaken
Laboratory of Medical Biochemistry, IBN ZOHR Hospital, Guelma 24000, Algeria
Ahmed Aimen
AA
Bentorki
Department of Infection Diseases, IBN ZOHR Hospital, Guelma 24000, Algeria
Amel
A
Touaref
Department of Hematology, IBN ZOHR Hospital, Guelma 24000, Algeria
Amina
A
Yekhlef
Laboratory of Medical Biochemistry, IBN ZOHR Hospital, Guelma 24000, Algeria
Fouzia
F
Sekkache
Department of Nephrology and Hemodialysis, IBN ZOHR Hospital, 24000 Guelma, Algeria
Nabila
N
Kouicem
D000328:Adult; D000368:Aged; D000462:Algeria / Q000453:epidemiology; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D006435:Renal Dialysis / Q000009:adverse effects*; D012189:Retrospective Studies; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D014527:Uric Acid