Palisaded neutrophilic and granulomatous dermatitis in association with subcutaneous nodular and systemic sarcoidosis.
Palisaded neutrophilic granulomatous dermatitis (PNGD) is a rare entity that has been clearly defined neither clinically nor histopathologically. PNGD has been associated with some immune-mediated disorders such as rheumatoid arthritis, systemic lupus erythematosus, systemic vasculitis, Behçet's disease, as well as with lymphoproliferative conditions, bacterial endocarditis, sarcoidosis, and various drugs. We present a 44-year-old Caucasian woman with roundish erythematous-livid plaque and erythematous papules on the left calf that were present for three months. Histopathology of plaque lesion showed palisading neutrophilic and granulomatous dermatitis. Subsequently, she developed a firm and tender nodule on the right calf. Histopathology of the nodule showed typical naked sarcoid granulomas in the dermis and subcutis. Additionally, the patient developed non-tender subcutaneous nodules on the cheeks, submandibular region and left breast with normal overlying skin, which were histopathologically diagnosed as sarcoid granuloma. Red eyes and lower visual acuity on the right eye were diagnosed as anterior uveitis. Therefore, systemic sarcoidosis was established. This is a case of PNGD described in an adult patient with sarcoidosis with cutaneous, breast, eye and lung involvement established by clinical, radiographic, laboratory, and histopathologic criteria.
Zrinjka Paštar, MD, PhD, Ministry of Defense, Av. Gojka Šuška 6 , HR-10000 Zagreb, Croatia; zpastar@hi.htnet.hr.
Zrinjka
Z
Paštar
Jaka
J
Radoš
Ivan
I
Pavić
Suzana
S
Kovačević
Anamarija
A
Vukasović
Višnja
V
Milavec-Puretić
Jasna
J
Lipozenčić
D000328:Adult; D015897:Comorbidity; D003872:Dermatitis / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D016460:Granuloma Annulare / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D017441:Necrobiotic Disorders / Q000453:epidemiology; D012507:Sarcoidosis / Q000188:drug therapy / Q000453:epidemiology*; D014606:Uveitis, Anterior / Q000453:epidemiology