Sulodexide and glycosaminoglycans in the progression of renal disease.
Experimental data in cell cultures and animal models suggest that sulodexide and glycosaminoglycans are potentially effective drugs to treat chronic kidney diseases and prevent progression to renal failure. However, no conclusive evidence support the use of them in human renal disease. In acute and chronic glomerulonephritis, only few studies have been performed. Sulodexide has been more intensely investigated in diabetic nephropathy (DN) where the body of data supports its effectiveness as an antialbuminuric agent in early stages. Unfortunately, there is no study in DN patients on the effect of sulodexide on clinical end points.
Division of Nephrology, Department of Biomedical and Surgical Sciences, University Hospital of Verona, Verona, Italy.
Valentina
V
Masola
Gianluigi
G
Zaza
Giovanni
G
Gambaro
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D018450:Disease Progression; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy*
D000925:Anticoagulants; D006025:Glycosaminoglycans; C007858:glucuronyl glucosamine glycan sulfate
FGF-2; diabetic nephropathy; glycosaminoglycans; heparanase-1; sulodexide