Suppression of the human carcinoma phenotype by an antioncogene ribozyme.
A spectrum of oncogenes have been identified and are thought to be associated with the progression of neoplasia. These oncogenes include the following: growth factors/receptors, kinases, nuclear proteins (i.e., Fos/Jun), and tumor suppressor genes. Perturbation of one or more of these genes can transform normal cells into invasive/metastatic cancer cells. Understanding the role of these oncogenes for specific types of cancer may lead to a more rational basis for tissue-specific targets in cancer gene therapy.
Department of Urology, Kitasato University Hospital, Kitasato, Japan.
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