Impact of metabolic syndrome on oncologic outcome after radical gastrectomy for gastric cancer.
BACKGROUND
Few studies have reported the relationship between MS and the prognosis of gastric cancer.


METHODS
Data were collected from 505 patients who underwent radical gastrectomy for gastric cancer between January 2006 and December 2007. After exclusion, remaining 204 patients were divided into two groups based on the presence of MS.


RESULTS
No significant differences were observed in tumor stage and grade between the MS (n=60) and non-MS (n=144) groups. The median follow-up periods were 53.2±23.5 and 54.7±22.1 months in for the MS and non-MS groups, respectively (P=0.677). Seventeen (28.3%) and 21 (14.6%) patients showed tumor recurrence in the MS and non-MS groups, respectively (P=0.022). In addition, disease-free survival of patients in the MS group was less than in non-MS group (P=0.036). The Cox regression hazard model demonstrated that advanced tumor stage (stage III or IV, HR=17.8, 95% CI=5.3 to 59.4) and presence of MS (HR=2.8, 95% CI=1.3 to 5.8) were independent risk factors for recurrence.


CONCLUSIONS
MS may be an important prognostic factor for gastric cancer. Control of MS could improve the therapeutic efficacy of gastric cancer.
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250, Seongsanno, Seodaemun-gu, 120-752 Seoul, Republic of Korea.
Eun Hye
EH
Kim
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250, Seongsanno, Seodaemun-gu, 120-752 Seoul, Republic of Korea. Electronic address: leehyuk.dr@gmail.com.
Hyuk
H
Lee
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250, Seongsanno, Seodaemun-gu, 120-752 Seoul, Republic of Korea.
Hyunsoo
H
Chung
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250, Seongsanno, Seodaemun-gu, 120-752 Seoul, Republic of Korea.
Jun Chul
JC
Park
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250, Seongsanno, Seodaemun-gu, 120-752 Seoul, Republic of Korea.
Sung Kwan
SK
Shin
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250, Seongsanno, Seodaemun-gu, 120-752 Seoul, Republic of Korea.
Sang Kil
SK
Lee
Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Woo Jin
WJ
Hyung
Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 250, Seongsanno, Seodaemun-gu, 120-752 Seoul, Republic of Korea.
Yong Chan
YC
Lee
Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea.
Sung Hoon
SH
Noh
D000230:Adenocarcinoma / Q000401:mortality* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000401:mortality*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000401:mortality* / Q000601:surgery