Multifunctional hybrid nanocarrier: magnetic CNTs ensheathed with mesoporous silica for drug delivery and imaging system.
Here we communicate the development of a novel multifunctional hybrid nanomaterial, magnetic carbon nanotubes (CNTs) ensheathed with mesoporous silica, for the simultaneous applications of drug delivery and imaging. Magnetic nanoparticles (MNPs) were first decorated onto the multiwalled CNTs, which was then layered with mesoporous silica (mSiO2) to facilitate the loading of bioactive molecules to a large quantity while exerting magnetic properties. The hybrid nanomaterial showed a high mesoporosity due to the surface-layered mSiO2, and excellent magnetic properties, including magnetic resonance imaging in vitro and in vivo. The mesoporous and magnetic hybrid nanocarriers showed high loading capacity for therapeutic molecules including drug gentamicin and protein cytochrome C. In particular, genetic molecule siRNA was effectively loaded and then released over a period of days to a week. Furthermore, the hybrid nanocarriers exhibited a high cell uptake rate through magnetism, while eliciting favorable biological efficacy within the cells. This novel hybrid multifunctional nanocarrier may be potentially applicable as drug delivery and imaging systems.
Institute of Tissue Regeneration Engineering (ITREN) and ⊥Department of Biomaterials Science, School of Dentistry , Dankook University , Cheonan 330-714, South Korea.
Rajendra K
RK
Singh
Kapil D
KD
Patel
Jung-Ju
JJ
Kim
Tae-Hyun
TH
Kim
Joong-Hyun
JH
Kim
Ueon Sang
US
Shin
Eun-Jung
EJ
Lee
Jonathan C
JC
Knowles
Hae-Won
HW
Kim
D000818:Animals; D004337:Drug Carriers; D016503:Drug Delivery Systems; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D046529:Microscopy, Electron, Transmission; D037742:Nanotubes, Carbon; D034741:RNA, Small Interfering / Q000008:administration & dosage; D012822:Silicon Dioxide / Q000737:chemistry*
D004337:Drug Carriers; D037742:Nanotubes, Carbon; D034741:RNA, Small Interfering; D012822:Silicon Dioxide