Highly efficient synthesis of polysubstituted pyrroles via four-component domino reaction.
A highly efficient, catalyst-free synthesis of polysubstituted pyrroles by means of a novel four-component domino reaction of an arylglyoxal monohydrate, an aniline, a dialkyl but-2-ynedioate, and malononitrile is reported. This transformation proceeded via a 6,6a-dihydrofuro[2,3-b]pyrrole as the key intermediate.
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, P. R. China, and School of Safety Engineering, China University of Mining & Technology , Xuzhou 221116, P. R. China.
Xian
X
Feng
Qian
Q
Wang
Wei
W
Lin
Guo-Lan
GL
Dou
Zhi-Bin
ZB
Huang
Da-Qing
DQ
Shi
D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
C000588680:6,6a-dihydrofuro(2,3-b)pyrrole; D000814:Aniline Compounds; D009570:Nitriles; D011758:Pyrroles; C000945:dicyanmethane; C023650:aniline