An MTHFR variant, plasma homocysteine levels and late-onset coronary artery disease in subjects from southern Iran.
There have been many controversial debates on the role of Hyperhomocysteinaemia (HHcy) as an independent risk factor for Coronary Artery Disease (CAD) during recent years. Furthermore, an alanine/valine (Ala/Val) gene polymorphism at 222nd amino acid of 5,10-methylenetetrahydrofolate reductase (MTHFR) has been considered as a factor that could render this enzyme thermolabile and less active which in turn may yield a subsequent increase in plasma total homocysteine (tHcy) levels. To assess whether this polymorphism is associated with increased risk of CAD and plasma levels of tHcy in a population from southern Iran, a total of 457 patients with angiographically documented multi-vessel CAD were compared with a control group comprised of 371 subjects with <30% stenosis in all major vessels. Nevertheless our results failed to admit a significant difference between CAD individuals and control subjects for Ala/Val polymorphism and plasma Hcy concentrations. However, plasma Hcy concentrations were significantly higher in individuals with Val/Val genotype than subjects with Ala/Ala genotype, but it didn't show a significant association with CAD in our population. Moreover, as the multiple linear regression analysis indicated, smoking habit, folate levels and the MTHFR Val/Val genotype were the only major predictors of tHcy concentrations in the current investigation.
Iranian Academic Center for Education, Culture and Research (ACECR), Fars Province Branch, Shiraz 71347, Iran.
Babak
B
Saffari
Iranian Academic Center for Education, Culture and Research (ACECR), Fars Province Branch, Shiraz 71347, Iran.
Sara
S
Senemar
Hematology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71937, Iran.
Mehran
M
Karimi
Iranian Academic Center for Education, Culture and Research (ACECR), Fars Province Branch, Shiraz 71347, Iran.
Marzieh
M
Bahari
Iranian Academic Center for Education, Culture and Research (ACECR), Fars Province Branch, Shiraz 71347, Iran.
Najmeh
N
Jooyan
Hematology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71937, Iran.
Majid
M
Yavarian
D017668:Age of Onset; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D023921:Coronary Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000000981:diagnostic imaging / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D007492:Iran / Q000453:epidemiology; D016014:Linear Models; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D015999:Multivariate Analysis; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D012307:Risk Factors
D015415:Biomarkers; D006710:Homocysteine; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)