Clinicoradiological characteristics of patients with differentiated thyroid carcinoma and renal metastasis: case series with follow up.
BACKGROUND
Renal metastasis is relatively unusual in patients with differentiated thyroid carcinoma.


METHODS
The clinicoradiological parameters of a series of patients with differentiated thyroid carcinoma and renal metastasis were assessed, together with follow-up data.


CONCLUSIONS
The series comprised 4 male patients over the age of 45 years with extensive disease at the primary site. Retro-sternal extension of a large goitre was observed in three patients. The primary tumour was 4 cm or larger in all patients (range, 4-14 cm), and three patients had associated lymph node metastasis. None had any genito-urinary symptoms at presentation. Two patients had isolated renal metastases with no other distant metastases, while the others had extensive multi-organ involvement. The bilateral occurrence of lesions was a hallmark, being observed in all cases. Ultrasound-guided fine needle aspiration cytology and 131I scintigraphy were pivotal in confirming the diagnosis. Evidence of 'flip-flop' between 131I study and fluoro-deoxyglucose positron emission tomography was noted in one patient, while the other three demonstrated concordant lesions in both modalities. At a minimum follow-up period of four years after diagnosis, three patients demonstrated stable disease with radioiodine therapy, and one had expired due to a poorly differentiated lung carcinoma which developed subsequently.
Radiation Medicine Centre (BARC), Tata Memorial Centre Annexe, Mumbai, India.
P
P
Kand
Radiation Medicine Centre (BARC), Tata Memorial Centre Annexe, Mumbai, India.
S
S
Basu
D018263:Adenocarcinoma, Follicular / Q000473:pathology; D002277:Carcinoma / Q000473:pathology; D002291:Carcinoma, Papillary; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D000077273:Thyroid Cancer, Papillary; D013964:Thyroid Neoplasms / Q000473:pathology*; D014463:Ultrasonography