[Adsorption and release behavior of epirubicin hydrochloride on carboxylated single-walled carbon nanotubes].
In this study, the adsorption behavior of epirubicin hydrochloride (EPI) on carboxylated single-walled carbon nanotubes (c-SWNTs) obtained by mixture acid treatment was investigated. The results indicated that the dispersion of c-SWNTs in water was obviously improved. The absorption of EPI on c-SWNTs came to equilibrium after 240 min and could be explained by pseudo-second-order model. Moreover, there were heterogeneous distribution of active sites onto c-SWNTs surface and the Freundlich isotherm model was better fit to describe the absorption precess of EPI on c-SWNTs. The absorption capacity of EPI on c-SWNTs increased obviously with the increasing pH and decreasing temperature. Compared with multi-walled carbon nanotubes, carboxylated multi-walled carbon nanotubes, SWNTs, c-SWNTs possessed higher absorption capacity for EPI. The controlled, targeted and sustained release of EPI from c-SWNTs-EPI could be instructive for the development of nano-carrier.
Yancheng Health Vocational and Technical College, Yancheng 224005, China.
Rui
R
Lin
Division of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Li-li
LL
Li
Division of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Jia
J
He
Yancheng Health Vocational and Technical College, Yancheng 224005, China.
Lan-lan
LL
Qiu
Division of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Hua
H
He
D000327:Adsorption; D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004337:Drug Carriers; D015251:Epirubicin / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D002264:Carboxylic Acids; D004337:Drug Carriers; D037742:Nanotubes, Carbon; D015251:Epirubicin