Interrelationship between procalcitonin and organ failure in sepsis.
Sepsis suffers from lack of specific clinical symptoms which contribute to one of the major causes of mortality. In the present study, our aim was to evaluate the role of a recent biomarker Procalcitonin (PCT) in predicting organ dysfunction. 71 patients admitted with sepsis were included in the study. PCT levels were measured at 0, 24, 72 h and 7th day and sequential organ failure assessment score (SOFA) scores were calculated. PCT levels significantly decreased (p < 0.001) in 89.3 % of surviving patients, whereas, in 60 % non surviving patients the PCT level increased significantly (p < 0.001). A significant positive correlation between PCT and SOFA score was observed in survivors at each hour. These observations indicate that PCT concentration is significantly associated with severity of multi organ dysfunction and also helps in determining the prognosis of septic patients.
Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, 110060 India.
Dimple
D
Anand
Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, 110060 India.
Sabari
S
Das
Department of Critical Care Medicine, Sir Ganga Ram Hospital, New Delhi, India.
Sumit
S
Ray
Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, 110060 India.
Seema
S
Bhargava
Department of Biochemistry, Sir Ganga Ram Hospital, New Delhi, 110060 India.
Lalit Mohan
LM
Srivastava
Biomarker; Organ dysfunction; Procalcitonin; Prognosis; Sepsis