An overview of recent developments in the treatment of heart failure: update from the ESC Congress 2013.
The European Society of Cardiology held their annual congress in Amsterdam between the 31st of August and 4 September 2013 to discuss the latest developments in the field. The meeting included an update of the latest treatments currently under investigation for the treatment of heart failure. Updates were provided on the RELAX-AHF study that had, for the first time, demonstrated an improvement in post-discharge outcome in patients with acute heart failure treated with seralaxin. The meeting also gave the opportunity to highlight the latest goings on from the promising agent omecamtiv mecarbil as shown in the ATOMIC-AHF study. Indeed, its unique inotropic effect showed a potential to improve dyspnea without increasing myocardial oxygen consumption. Other presentations at the meeting included: a recent study evaluating ultrafiltration in the treatment of acute HF with renal impairment and the effects of the vasodilator cinaciguat. The unremarkable results from the recent ASTRONAUT study with aliskiren were also touched upon. It is important to note that while the data from seralaxin and omecamtiv mecarbil has been promising, the long term benefits of these therapies in heart failure still need to be evaluated. The authors also highlight the need for these promising agents to be further evaluated in women and other ethnic groups.
Applied Cachexia Research, Charité Medical School, Department of Cardiology , Campus Virchow-Klinikum, Augustenburger Platz 1, D - 13353 Berlin , Germany +49 30 450 553 577 ; +49 30 450 553 951 ; miroslava.valentova@charite.de.
Miroslava
M
Valentova
Stephan
S
von Haehling
D000577:Amides / Q000627:therapeutic use; D001565:Benzoates / Q000627:therapeutic use; D058406:Cardiac Resynchronization Therapy; D002316:Cardiotonic Agents / Q000627:therapeutic use; D005650:Fumarates / Q000627:therapeutic use; D006333:Heart Failure / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D012065:Relaxin / Q000627:therapeutic use; D014462:Ultrafiltration; D014508:Urea / Q000031:analogs & derivatives / Q000627:therapeutic use
D000577:Amides; D001565:Benzoates; D002316:Cardiotonic Agents; D005650:Fumarates; D011994:Recombinant Proteins; C577649:serelaxin protein, human; C547293:omecamtiv mecarbil; C480588:BAY 58-2667; C446481:aliskiren; D014508:Urea; D012065:Relaxin