[Preparation and molluscicidal effect of 5% niclosamide ethanolamine granules].
OBJECTIVE
To explore the preparation of 5% niclosamide ethanolamine granules and evaluate its molluscicidal effect.


METHODS
The optimal formula was obtained by the selection of wetting agents, dispersants, adhesives and carriers. The molluscicidal effect of 5% niclosamide ethanolamine granules was measured by the spray methods in the laboratory and field.


RESULTS
The mixed 5% niclosamide ethanolamine, 0.2% sodium lauryl sulfate, and 1% alkylphenol sulfonic polyxyethylene ether sulfonate were crushed by gas flow, and then mixed with 93.7% quartz sand and 0.1% polyvinyl alcohol water solution, drying to 5% niclosamide ethanolamine granules. The density, bulk density, and moisture of 5% niclosamide ethanolamine granules were 1.4 g/ml, 1.3 g/ml, and 2.4%, respectively, and the hot storage stability was qualified. Under the lab condition, the death rates of Oncomelania hupensis snails sprayed with 0.5 g/m2 (7 d) or 1.0 g/m2 (1 d) of 5% niclosamide ethanolamine granules were higher than 95%. In the field, the death rates of the snails sprayed with 0.5 g/m2 (7 d) or 1.0 g/m2 (1 d) were higher than 85%.


CONCLUSIONS
There is a high molluscicidal effect of 5% niclosamide ethanolamine granules and it is suitable for field application.
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 14064, China.
Yun-tian
YT
Xing
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 14064, China.
Jian-rong
JR
Dai
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 14064, China.
Yang
Y
Dai
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 14064, China.
Zhen-kun
ZK
Yang
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 14064, China.
Fei
F
Wang
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 14064, China.
Xiao-tian
XT
Liang
Jiangsu Aifin Agrochemical Co., Ltd. China.
Bo
B
Ma
Jiangsu Aifin Agrochemical Co., Ltd. China.
Guo-li
GL
Qu
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 14064, China.
Wei
W
Wang
Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Disease Prevention and Control, Ministry of Health, Jiangsu Provincial Key Laboratory of Molecular Biology of Parasites, Wuxi 14064, China.
You-sheng
YS
Liang
D000818:Animals; D019856:Ethanolamine / Q000494:pharmacology*; D008975:Molluscacides / Q000494:pharmacology*; D009534:Niclosamide / Q000494:pharmacology*; D012908:Snails / Q000187:drug effects
D008975:Molluscacides; D019856:Ethanolamine; D009534:Niclosamide