Baroreceptor sensitivity and diabetes mellitus.
Diabetes mellitus (DM) is a disease of increasing incidence and prevalence. Arterial baroreceptors are stretch-sensitive receptors, which in a reflex manner are involved in the homeostatic control of arterial blood pressure. Diabetic subjects have depressed baroreflex sensitivity (BRS), although the exact pathomechanisms are unclear. In this review, we discuss the features, clinicaland prognostic implications of reduced BRS for diabetic patients and the potential involvement of cardiovascular autonomic neuropathy and atherosclerosis. Finally, we demonstrate evidence on interventions (e.g. pioglitazone, alpha-lipoic acid, leptin, fluvastatin, physicaltraining etc.) which could improve BRS and ameliorate cardiovascular autonomic dysfunction in diabetic patients.
Department of Physiology, Wroclaw Medical University, Wroclaw, Poland. olurowe@yahoo.com.
Olumide Olatubosun
OO
Rowaiye
Ewa Anita
EA
Jankowska
Beata
B
Ponikowska
D000818:Animals; D062186:Arterial Pressure; D001341:Autonomic Nervous System / Q000503:physiopathology*; D017704:Baroreflex; D002319:Cardiovascular System / Q000294:innervation*; D003929:Diabetic Neuropathies / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D042241:Early Diagnosis; D006801:Humans; D011237:Predictive Value of Tests; D011311:Pressoreceptors / Q000503:physiopathology*; D011379:Prognosis