6'-O-Caffeoylarbutin inhibits melanogenesis in zebrafish.
6'-O-Caffeoylarbutin, an arbutin derivative, is a naturally occurring glucoside of hydroquinone from Vaccinium dunalianum. On anti-melanogenic effect assay, 6'-O-caffeoylarbutin expressed a stronger anti-melanin activity in a dose-dependent manner with about a two-fold more than that of arbutin, but with less toxicity about a two-fold lower than that of arbutin. In addition, melanin synthesis could be fully recovered after the removal of 6'-O-caffeoylarbutin. The result suggested that 6'-O-caffeoylarbutin could be a candidate natural product to serve as a skin-whitening ingredient with the merits of potent melanin inhibition, less toxicity and reversible melanin synthesis after stopping use.
a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , P.R. China.
Min
M
Xu
Qiao-Cong
QC
Lao
Ping
P
Zhao
Xiao-Yu
XY
Zhu
Hong-Tao
HT
Zhu
Xu-Lu
XL
Luo
Chong-Ren
CR
Yang
Jian-Hui
JH
He
Chun-Qi
CQ
Li
Ying-Jun
YJ
Zhang
D000818:Animals; D001104:Arbutin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006873:Hydroquinones / Q000737:chemistry; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012867:Skin / Q000187:drug effects; D015027:Zebrafish / Q000378:metabolism*
C000592587:6'-O-caffeoylarbutin; D002109:Caffeic Acids; D006873:Hydroquinones; D008543:Melanins; D001104:Arbutin; C031927:hydroquinone
6′-O-caffeoylarbutin; Vaccinium dunalianum; anti-melanogenic