Effect of Aqueous Extract of Giant Horsetail (Equisetum giganteum L.) in Antigen-Induced Arthritis.
Equisetum giganteum is a plant used in traditional medicine as diuretic. From our knowledge this is the first time this plant is tested in an in vivo model of acute inflammation. To evaluate the effect of aqueous extract of giant horsetail (AEGH) as immunomodulatory therapy, antigen-induced arthritis (AIA) was generated in mice with methylated bovine serum albumin (mBSA). Inflammation was evaluated by articular nociception, leukocytes migration and lymphocyte proliferation. AEGH reduced nociception at 3, 6 and 24 h (P < 0.01), decreased leukocyte migration (P < 0.015), and inhibited lymphocyte proliferation stimulated with Concanavalin A and Lipopolysaccharide (P < 0.05). In conclusion, AEGH has an anti-inflammatory potential in acute model of inflammation, as well as immunomodulatory effect on both B and T lymphocytes, with an action independent of cytotoxicity.
Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350 - CEP 90035-903, Bairro Rio Branco, Porto Alegre/RS, Brazil ; Instituto de CiÊncias BÁsicas da SaÚde, Universidade Federal do Rio Grande do Sul, Rua Sarmento Leite, 500 - CEP 90010-170, Bairro Centro, Porto Alegre/RS, Brazi.
Mirian
M
Farinon
Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350 - CEP 90035-903, Bairro Rio Branco, Porto Alegre/RS, Brazil ; Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2400 - CEP 90035-003, Bairro Santa CecÍlia, Porto Alegre/RS, Brazil.
Priscila Schmidt
PS
Lora
Departamento de ProduÇÃo de MatÉria-Prima, Faculdade de FarmÁcia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752 - CEP 90610-000, Bairro Santana, Porto Alegre/RS, Brazil.
Leandro Nicolodi
LN
Francescato
Departamento de ProduÇÃo de MatÉria-Prima, Faculdade de FarmÁcia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752 - CEP 90610-000, Bairro Santana, Porto Alegre/RS, Brazil.
Valquiria Linck
VL
Bassani
Departamento de ProduÇÃo de MatÉria-Prima, Faculdade de FarmÁcia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752 - CEP 90610-000, Bairro Santana, Porto Alegre/RS, Brazil.
Amélia Teresinha
AT
Henriques
Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350 - CEP 90035-903, Bairro Rio Branco, Porto Alegre/RS, Brazil ; Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2400 - CEP 90035-003, Bairro Santa CecÍlia, Porto Alegre/RS, Brazil.
Ricardo Machado
RM
Xavier
Serviço de Reumatologia, Hospital de Clínicas de Porto Alegre, Rua Ramiro Barcelos, 2350 - CEP 90035-903, Bairro Rio Branco, Porto Alegre/RS, Brazil ; Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2400 - CEP 90035-003, Bairro Santa CecÍlia, Porto Alegre/RS, Brazil.
Patricia Gnieslaw
PG
de Oliveira
Antigen-Induced Arthritis (AIA); Equisetum giganteum L.; aqueous extract of giant horsetail (AEGH); immunomodulatory therapy.