Where long noncoding RNAs meet DNA methylation.
DNA methylation is a fundamental epigenetic mechanism governing regulation of gene expression during mammalian development. A recent study published in Nature shows a novel long noncoding RNA (lncRNA) arising from the CEBPA gene locus (termed ecCEBPA) that is critical for regulation of DNA methylation at this site through the association of ecCEBPA with DNA methyltransferase 1, DNMT1.
Wistar Institute, Philadelphia, PA 19104, USA.
Fan
F
Lai
Wistar Institute, Philadelphia, PA 19104, USA.
Ramin
R
Shiekhattar
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D045744:Cell Line, Tumor; D018899:CpG Islands; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000378:metabolism; D019175:DNA Methylation; D006801:Humans; D062085:RNA, Long Noncoding / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism
D022762:CCAAT-Enhancer-Binding Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D004248:DNA (Cytosine-5-)-Methyltransferases