Copper-catalyzed ortho-C-H amination of protected anilines with secondary amines.
A practical Cu-catalyzed picolinamide-directed o-amination of anilines showing excellent mono-substitution selectivity and high functional group tolerance has been developed.
Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. n.rodriguez@uam.es ramon.gomez@uam.es.
Ángel Manu
ÁM
Martínez
Nuria
N
Rodríguez
Ramón Gómez
RG
Arrayás
Juan C
JC
Carretero
D000586:Amination; D000588:Amines / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry
D000588:Amines; D000814:Aniline Compounds; D002244:Carbon; D003300:Copper; D006859:Hydrogen