Tenascins in stem cell niches.
Tenascins are extracellular matrix proteins with distinct spatial and temporal expression during development, tissue homeostasis and disease. Based on their expression patterns and knockout phenotypes an important role of tenascins in tissue formation, cell adhesion modulation, regulation of proliferation and differentiation has been demonstrated. All of these features are of importance in stem cell niches where a precise regulation of growth versus differentiation has to be guaranteed. In this review we summarize the expression and possible functions of tenascins in neural, epithelial and osteogenic stem cell niches during normal development and organ turnover, in the hematopoietic and pro-inflammatory niche as well as in the metastatic niche during cancer progression.
Friedrich Miescher Institute of Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66 CH-4058 Basel, Switzerland; Faculty of Sciences, University of Basel, Switzerland. Electronic address: ruth.chiquet@fmi.ch.
Ruth
R
Chiquet-Ehrismann
Inserm U1109, The Microenvironmental Niche in Tumorigenesis and Targeted Therapy (MNT3) Team, 3 av. Molière, 67200 Strasbourg, France; Université de Strasbourg, 67000 Strasbourg, France; LabEx Medalis, Université de Strasbourg, 67000 Strasbourg, France; Fédération de Médecine Translationnelle de Strasbourg (FMTS), 67000 Strasbourg, France. Electronic address: orend@inserm.fr.
Gertraud
G
Orend
Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Freiburgstrasse 7, CH-3010 Bern, Switzerland. Electronic address: matthias.chiquet@zmk.unibe.ch.
Matthias
M
Chiquet
Department of Cell Biology and Human Anatomy, University of California Davis, Davis, CA 95616, USA.
Richard P
RP
Tucker
The Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7FYUnited Kingdom. Electronic address: Kim.Midwood@kennedy.ox.ac.uk.
Kim S
KS
Midwood
D002454:Cell Differentiation / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D006801:Humans; D009362:Neoplasm Metastasis / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D058953:Neural Stem Cells / Q000378:metabolism*; D010012:Osteogenesis / Q000502:physiology*; D039904:Pluripotent Stem Cells / Q000378:metabolism; D019063:Tenascin / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*
D019063:Tenascin
Cancer; Development; Hematopoiesis; Inflammation; Stem cell niche; Tenascin