[Progress in the study of carbonic anhydrase inhibitors as potential anticancer drugs].
Carbonic anhydrase IX (CA IX) is a tumor associated protein which is able to be a potent anticancer target, since it is highly expressed in a multitude of carcinomas, while it is present in a limited number of normal tissues. This review focuses on its role in tumor physiology, the most recent three dimensional structure features of this enzyme which has recently been elucidated. In addition, we present recent advances in the development of small inhibitors able to target CA IX for therapeutic applications.
Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, China.
Jia
J
Guo
Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, China.
Feng-ran
FR
Li
Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, China.
Yang
Y
Liu
Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, China.
Mao-sheng
MS
Cheng
D000951:Antigens, Neoplasm / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D000071231:Carbonic Anhydrase IX; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000627:therapeutic use*; D002256:Carbonic Anhydrases / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*
D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D002257:Carbonic Anhydrase Inhibitors; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases