More than a masquerade syndrome: atypical presentations of vitreoretinal lymphomas.
OBJECTIVE
To present a population of patients sharing atypical manifestations of vitreoretinal lymphoma (VRL).


METHODS
Institutional case series in a single tertiary center. Patients with cytologically proven VRL, referred between November 2009 and May 2010, were retrospectively reviewed. Diagnosis of VRL was based on cytology of vitreous samples, immunohistochemistry, and molecular biology. Patients with confirmed VRL and clinical features different from the typical manifestations were included. Demographical and clinical characteristics of these patients were studied.


RESULTS
Twelve cases of VRL were diagnosed. Four cases (2M/2F) were considered atypical (A-VRL) in their presentations. Mean age for typical lymphoma (T-VRL) was 71.9 years (range: 62-87 years); mean age for A-VRL was 54 years (range: 50-59 years).


CONCLUSIONS
Diagnosis of VRL is challenging and diagnostic delay is frequent. The authors describe a series of patients sharing common characteristics, such as a younger age (p = 0.05), severe anterior chamber reaction, mild or no vitritis, and possible fulminant evolution.
Department of Ophthalmology and.
Abdullah
A
AlQahtani
Valerie
V
Touitou
N
N
Cassoux
Cedric
C
Aknin
Helene
H
Merle-Beral
Bahram
B
Bodaghi
Phuc
P
LeHoang
D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D057210:Delayed Diagnosis; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000601:surgery; D012189:Retrospective Studies; D013577:Syndrome; D013997:Time Factors; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D016207:Cytokines
Acute retinal necrosis; intraocular lymphoma; masquerade syndrome; tuberculosis