Myoepithelioma of the ovary: first reported case.
A wide variety of neoplasms of varying histogenesis occur within the ovary. We report the first case of a primary ovarian myoepithelioma, a diagnosis made on the basis of the morphologic features coupled with immunoreactivity with epithelial and myoid markers. The tumor had a lobulated appearance with variable architectural patterns including anastomosing cords, trabeculae, and nests of epithelioid to spindled tumor cells within a hyalinised and focally myxoid stroma. Fluorescence in situ hybridization for EWS gene rearrangement and reverse transcriptase polymerase chain reaction for EWSR1-POU5F1 and EWSR1-PBX1, molecular abnormalities which are found in some extrasalivary myoepitheliomas, were negative. In reporting this unique neoplasm, we discuss the wide differential diagnosis generated by the case.
Department of Pathology (O.P.H., W.G.M.), Royal Group of Hospitals, Belfast, Northern Ireland Department of Musculoskeletal Pathology (V.P.S.), Royal Orthopaedic Hospital, Birmingham, UK Department of Pathology, Bronovo Hospital (S.A.J.L.), Hague, The Netherlands.
Oisín P
OP
Houghton
Vaiyapuri P
VP
Sumathi
Sabine A J
SA
Loyson
W Glenn
WG
McCluggage
D005260:Female; D006801:Humans; D008875:Middle Aged; D009208:Myoepithelioma / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D010053:Ovary / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome