Development of a fluorescent sensor for illicit date rape drug GHB.
The first fluorescent sensor (GHB Orange) for date rape drug GHB was developed. It exhibits the fluorescence quenching property for GHB and allows its detection in various drinks. The interaction mechanism was elucidated as intramolecular charge transfer induced by a hydrogen bond. This discovery will help in solving the drug facilitated sexual assault problems.
Department of Chemistry and MedChem Program, Life Sciences Institude, National University of Singapore, 3 Science Drive 3, Singapore 117543. chmcyt@nus.edu.sg.
Duanting
D
Zhai
Yong Qiao Elton
YQ
Tan
Wang
W
Xu
Young-Tae
YT
Chang
D001628:Beverages / Q000032:analysis*; D002492:Central Nervous System Depressants / Q000032:analysis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry*; D006860:Hydrogen Bonding; D006885:Hydroxybutyrates / Q000032:analysis* / Q000737:chemistry; D013287:Illicit Drugs / Q000032:analysis* / Q000737:chemistry; D011902:Rape
D002492:Central Nervous System Depressants; D005456:Fluorescent Dyes; D006885:Hydroxybutyrates; D013287:Illicit Drugs; C111420:4-hydroxybutyric acid