[Effect of Jiangzhi Kangyanghua mixture on high-sensitivity C-reactive protein and vascular endothelial functions of hypertension patients].
To observe the effect of Jiangzhikangyanghua Mixture on high-sensitivity CRP (hs-CRP) and vascular endothelial functions of essential hypertension (EH) patients. In this study, 72 cases of out-patients with EH were selected from department of cardiology of Wujin hospital of traditional Chinese Medicine, and randomly divided into the control group (n= 36, amlodipine 5 mg qd + valsartan 80 mg qd) and the test group (n =36 amlodipine 5 mg qd + valsartan 80 mg qd + Jiangzhikangyanghua mixture 20 mL tid). The contents of hs-CRP, ET-1 and NO were measured before and after treatment for two months. The result showed that the contents of hs-CRP, ET-1 in both groups reduced (P <0. 05) , while the test group show a more significant reduction than the control group (P <0. 05). After the treatment, the content of NO raised in both group, while the test group show a more significant increase than that of the control group (P <0. 05). This study indicated that Jiangzhi Kangyanghua mixture could reduce the contents of hs-CRP and ET-1 and raise NO of EH patients.
Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China. qwd213161@163.com
Wei-Dong
WD
Qian
Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China.
Zhu-Yuan
ZY
Fang
Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China.
Wei-Min
WM
Jiang
Changzhou Wujin Hospital of Traditional Chinese Medicine, Changzhou 213161, China.
Hai-Ting
HT
Lu
D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002097:C-Reactive Protein / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D019332:Endothelin-1 / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; D002097:C-Reactive Protein