The effect of polymerization method in stereo-active block copolymers on the stability of polymeric micelles and their drug release profile.
OBJECTIVE
To investigate the effect of polymerization method on the stability and drug release properties of polymeric micelles formed using stereo-active block copolymers.


METHODS
Diblock copolymers consisting of methoxy poly ethylene oxide (MePEO) and poly(lactide)s (PLA)s of different stereochemistry were synthesized by bulk or solution polymerization. Polymers and micelles were characterized for their chemical structure by (1)H NMR, optical rotation by polarimetry, critical micellar concentration by fluorescence spectroscopy, thermal properties by differential scanning calorimetry, morphology by transmission electron microscopy and size as well as kinetic stability by dynamic light scattering. Release of encapsulated nimodipine from polymeric micelles at different levels of loading was also investigated.


RESULTS
Solution polymerization yielded a higher degree of crystallinity for stereo-regular PLA blocks. Consequently, the related polymeric micelles were kinetically more stable than those prepared by bulk polymerization. At high drug loading levels, the release of nimodipine was more rapid from polymeric micelles with crystalline cores. At lower levels of drug loading, drug release was slower and independent of the stereochemistry of the core.


CONCLUSIONS
The results underline the effect of polymerization method in defining core crystallinity in stereoregular block copolymer micelles. It also shows the impact of core crystallinity on enhancing micellar stability and drug release.
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, T6G 2E1, Canada.
Hoda
H
Soleymani Abyaneh
Mohammad Reza
MR
Vakili
Afsaneh
A
Lavasanifar
D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D065546:Drug Liberation; D007700:Kinetics; D008823:Micelles; D009553:Nimodipine / Q000008:administration & dosage / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D011108:Polymers; D012996:Solutions; D013237:Stereoisomerism; D013816:Thermodynamics
D004337:Drug Carriers; D008823:Micelles; D004364:Pharmaceutical Preparations; D011091:Polyesters; D011108:Polymers; D012996:Solutions; D011092:Polyethylene Glycols; C033616:poly(lactide); D009553:Nimodipine