MiR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells.
MicroRNAs play critical roles in the development and progression of non-small cell lung cancer (NSCLC). miR-96 acts as an oncogene in some malignancies, while its role in NSCLC is unclear. Here, we validated that miR-96 was significantly increased in both human NSCLC tissues and cell lines. Inhibition of miR-96 expression remarkably reduced cell proliferation, colony formation, migration, and invasion of NSCLC cells. Reversion-inducing-cysteine-rich protein with kazal motifs (RECK) was identified as a target of miR-96 in NSCLC cells. In addition, the expression of RECK was found to be negatively correlated with the expression of miR-96 in NSCLC tissues. Our data suggest that miR-96 might promote the growth and motility of NSCLC cells partially by targeting RECK.
Department of thoracic surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China.
Haizhou
H
Guo
Qianping
Q
Li
Weihao
W
Li
Tianliang
T
Zheng
Song
S
Zhao
Zhangsuo
Z
Liu
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000235:genetics; D049109:Cell Proliferation; D058851:GPI-Linked Proteins / Q000096:biosynthesis* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*
D058851:GPI-Linked Proteins; C541492:MIRN96 microRNA, human; D035683:MicroRNAs; C115460:RECK protein, human