Memory deficits in aging and neurological diseases.
Memory is central to our ability to perform daily life activities and correctly function in society. Improvements in public health and medical treatment for a variety of diseases have resulted in longer life spans; however, age-related memory impairments have been significant sources of morbidity. Loss in memory function is not only associated with aging population but is also a feature of neurodegenerative diseases such as Alzheimer's disease and other psychiatric and neurological disorders. Here, we focus on current understanding of the impact of normal aging on memory and what is known about its mechanisms, and further review pathological mechanisms behind the cause of dementia in Alzheimer's disease. Finally, we discuss schizophrenia and look into abnormalities in circuit function and neurotransmitter systems that contribute to memory impairment in this illness.
Laboratory of Neurobiology at CIMES, University of Málaga, Málaga, Spain; Department of Medicine at Faculty of Medicine, University of Málaga, Málaga, Spain.
Zafar U
ZU
Khan
Laboratory of Neurobiology at CIMES, University of Málaga, Málaga, Spain; Department of Pharmacology at Faculty of Medicine, University of Málaga, Málaga, Spain.
Elisa
E
Martín-Montañez
Laboratory of Neurobiology at CIMES, University of Málaga, Málaga, Spain; Department of Medicine at Faculty of Medicine, University of Málaga, Málaga, Spain.
Irene
I
Navarro-Lobato
Atlanta Department of Veterans Affairs Medical Center, Decatur, Georgia, USA; Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA; Division of Neuropharmacology and Neurological Diseases, Yerkes National Primate Research Center, Atlanta, Georgia, USA.
E Chris
EC
Muly
D000375:Aging / Q000502:physiology*; D000818:Animals; D006801:Humans; D008569:Memory Disorders / Q000150:complications / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology*
Aging; Alzheimer's disease; Cognitive dysfunction; Cytoskeleton; Epigenetic; Extracellular matrix; Memory loss; Neural networks; Neurotransmitter systems; Schizophrenia