Epigenetic studies of suicidal behavior.
Recent studies have shown an association between gene alterations by epigenetic mechanisms and suicidal behavior. These epigenetic mechanisms are mitotically, and in some cases meiotically, heritable changes in the genome through non-DNA sequence coding processes that alter gene expression as a result of variable changes in environmental stimuli. Genome-wide association studies have been inconsistent in elucidating the association between genes and suicidal behavior, thereby making the heritability of suicidal behavior is unclear. However, recent epigenetic studies have provided evidence that epigenetic mechanisms could deliver the missing link between the heritability of suicidal behavior and the interaction between environment and the genome. The present review provides an in-depth discussion of epigenetic mechanisms that may regulate gene expression in suicidal behavior. The findings of current epigenetic studies on suicidal behavior will also be discussed considering future epigenome-wide association studies on elucidating the contributions of environment and genome on suicidal behavior.
a Group for Suicide Studies, CAMH, Department of Psychiatry , University of Toronto , Toronto , Canada.
Ali
A
Bani-Fatemi
Aaron S
AS
Howe
Vincenzo
V
De Luca
D044127:Epigenesis, Genetic; D006801:Humans; D016728:Self-Injurious Behavior / Q000235:genetics*; D013405:Suicide
DNA methylation; epigenetics; histone; microRNA; suicide