Copper-mediated oxidative decarboxylative coupling of arylpropiolic acids with dialkyl H-phosphonates in water.
An efficient, mild, and generally applicable protocol for copper-mediated oxidative decarboxylative coupling of arylpropiolic acids with dialkyl H-phosphonates in water has been developed. Note that the reaction could proceed smoothly under air at relatively low temperature (60 °C), and the addition of isopropanol could successfully suppress the decomposition of dialkyl H-phosphonates in water.
The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University , Zhengzhou 450052, People's Republic of China.
Xiang
X
Li
Fan
F
Yang
Yangjie
Y
Wu
Yusheng
Y
Wu
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry*; D058451:Oxidative Coupling; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D000480:Alkynes; D063065:Organophosphonates; D011422:Propionates; D014867:Water; D003300:Copper; C011537:propiolic acid