O ROM(e)O1, ROM(e)O1, wherefore art thou ROM(e)O1?
Mitochondria are not only a source but also a target of reactive oxygen species (ROS). However, the molecular mechanisms by which ROS affect mitochondrial function are poorly defined. In this issue, Screaton and colleagues report that ROS modulator protein 1 (ROMO1) links ROS and mitochondrial morphology and ultrastructure by modulating cristae remodeling and mitochondrial fusion that depends on the guanosine triphosphatase Opa1. Their work indicates how the oxidative milieu triggers mitochondrial shape changes.
Department of Biology and Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, University of Padova, Padova 35121, Italy.
Martina
M
Semenzato
Luca
L
Scorrano
D000818:Animals; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D063154:Mitochondrial Dynamics / Q000502:physiology; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D008565:Membrane Proteins; D024101:Mitochondrial Proteins; C513338:ROMO1 protein, human; D017382:Reactive Oxygen Species; D020558:GTP Phosphohydrolases; C415198:OPA1 protein, human