Silver-coated monolithic columns for separation in radiopharmaceutical applications.
In this study, we demonstrate the preparation of a macroporous monolithic column containing anchored silver nanoparticles and its use for the elimination of excess radioiodine from the radiolabeled pharmaceutical. The poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith was first functionalized with cystamine and the free thiol groups liberated by reaction with borohydride. In-house-prepared silver nanoparticles were then attached by interaction with the surface thiols. The deiodization process was demonstrated with the commonly used radiopharmaceutical m-iodobenzylguanidine labeled with radionuclide iodine-125.
Institute of Macromolecular Chemistry of the Academy of Sciences of the Czech Republic, Public Research Institution, Prague, Czech Republic; The Molecular Foundry, E. O. Lawrence Berkeley National Laboratory, Berkeley, CA, USA.
Ondrej
O
Sedlacek
Jan
J
Kucka
Frantisek
F
Svec
Martin
M
Hruby
D019797:3-Iodobenzylguanidine / Q000302:isolation & purification*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008768:Methylmethacrylates / Q000737:chemistry*; D016062:Porosity; D019275:Radiopharmaceuticals / Q000302:isolation & purification*; D012834:Silver / Q000737:chemistry*; D013499:Surface Properties
D008768:Methylmethacrylates; D019275:Radiopharmaceuticals; C020347:GMA-EDMA; D019797:3-Iodobenzylguanidine; D012834:Silver
Capture; Iodide; Iodine; Monoliths; Silver nanoparticles