Platelet rich plasma for treatment of nonhealing diabetic foot ulcers: a case report.
Diabetic foot ulcers are one of the most important causes of lower limb amputations worldwide. The conventional treatments of diabetic foot ulcers are costly and often require patients to be hospitalized for long periods of time, thus representing a huge burden on any health care system. The use of autologous platelet-rich plasma (PRP), which is rich in multiple growth factors, may bear some similarities to the natural wound healing process. Nonetheless, few studies on human subjects have so far addressed the efficacy of PRP as a novel and minimally invasive treatment. Today, there is only 1 approved and available system to separate PRP from a patient's own blood in order to be used in diabetic ulcers. This system incorporates bovine thrombin for activation of PRP gel and may be applied by many healthcare providers without the need for extensive special training. In this report, a patient with extensive diabetic foot ulcers, non-responsive to other treatment modalities, was successfully treated by PRP.
Shahid Beheshti University Medical Sciences, Tehran, Iran.
Masoud
M
Mehrannia
Infection disease specialist, postdoc in diabetic foot, social security fund, Moayri Hospital, Tehran, Iran.
Mitra
M
Vaezi
Assistant Professor of Anesthesia, Tehran Heart Center & Women Hospitals, Tehran University of Medical Sciences, Tehran, Iran.
Fardin
F
Yousefshahi
Infection disease specialist, postdoc in diabetic foot, social security fund, Moayri Hospital, Tehran, Iran. Electronic address: swt_f@yahoo.com.
Nahid
N
Rouhipour
D000368:Aged; D002056:Burns / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D017719:Diabetic Foot / Q000473:pathology / Q000628:therapy*; D005528:Foot / Q000473:pathology; D006801:Humans; D008297:Male; D053657:Platelet-Rich Plasma; D014945:Wound Healing / Q000502:physiology*
autologous; autologue; cicatrisation; diabetic foot; pied diabétique; plasma riche en plaquettes; platelet-rich plasma; therapy; thérapie; ulcer; ulcère; wound healing