Description of five novel HLA-B alleles, B*07:184, B*41:27, B*42:19, B*50:32 and B*57:63, identified in Brazilian individuals.
Five novel HLA-B alleles were identified by HLA-SBT typing in seven unrelated Brazilian individuals. The new alleles discovered include HLA-B*07:184, B*41:27, B*42:19, B*50:32 and B*57:63 and were officially named by the World Health Organization (WHO) Nomenclature Committee. All new HLA-B alleles had nonsynonymous nucleotide substitution polymorphisms when compared to their most closely related HLA-B allele.
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil; Departamento da Ciência da Computação, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil; IMUNOLAB-Laboratório de Histocompatibilidade, Imunogenética e Imunologia de Transplantes, Belo Horizonte, Brasil.
R A
RA
Fabreti-Oliveira
M A
MA
Santos
C K F
CK
Oliveira
E M G
EM
Vale
B
B
Vilela
E
E
Nascimento
D000293:Adolescent; D000328:Adult; D000483:Alleles; D001483:Base Sequence; D016026:Bone Marrow Transplantation; D001938:Brazil; D005091:Exons; D005260:Female; D015870:Gene Expression; D015235:HLA-B Antigens / Q000235:genetics* / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D014019:Tissue Donors
D015235:HLA-B Antigens