Msx1 Gene Variant - its Association in Isolated Hypodontia: A Case Control Genetic study!!!
BACKGROUND
Non-syndromic tooth agenesis is a congenital anomaly with significant medical, psychological, and social ramifications. There is sufficient evidence to hypothesize that locus for this condition can be identified by candidate genes.


OBJECTIVE
The aim of this study was to test whether MSX1 671 T > C gene variant was involved in etiology of non-syndromic tooth agenesis in Raichur patients.


METHODS
Blood samples were collected with informed consent from 50 subjects having non-syndromic tooth agenesis and 50 controls. Genomic deoxyribonucleic acid (DNA) was extracted from the blood samples, polymerase chain reaction (PCR) was performed, and restriction fragment length polymorphism (RFLP) was performed for digestion products that were evaluated.


RESULTS
The results showed positive correlation between MSX1671 T > C gene variant and non-syndromic tooth agenesis in Raichur patients.


CONCLUSIONS
MSX1 671 T > C gene variant may be a good screening marker for non-syndromic tooth agenesis in Raichur patients.
Department of Orthodontics, Academy of Medical Education's Dental College and Hospital, Raichur, Karnataka, India.
Naveen Admala
NA
Reddy
Department of Orthodontics, Academy of Medical Education's Dental College and Hospital, Raichur, Karnataka, India.
Gopinath
G
Adusumilli
Department of Orthodontics, Academy of Medical Education's Dental College and Hospital, Raichur, Karnataka, India.
Raghu
R
Devanna
Department of Orthodontics, Academy of Medical Education's Dental College and Hospital, Raichur, Karnataka, India.
Rohra G
RG
Mayur
Department of Orthodontics, Academy of Medical Education's Dental College and Hospital, Raichur, Karnataka, India.
Saravanan
S
Pichai
Department of Orthodontics, Academy of Medical Education's Dental College and Hospital, Raichur, Karnataka, India.
Sharmila
S
Arujnan
MSX1 mutation; non-syndromic; tooth agenesis