Gender-dependent associations of CDKN2A/2B, KCNJ11, POLI, SLC30A8, and TCF7L2 variants with type 2 diabetes in (North African) Tunisian Arabs.
We investigated the impact of gender on T2DM association with confirmed susceptibility loci. CDKN2A/2B rs10811661, KCNJ11 rs5219, and TCF7L2 rs7903146 were associated with T2DM in females, while POLI rs488846 was associated with T2DM among males; the association of SLC30A8 rs13266634 and TCF7L2 rs4506565, rs12243326, and rs12255372 with T2DM was gender-independent.
Research Unit of Biology and Genetics of Hematological and Autoimmune diseases, Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia.
Amira
A
Turki
Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain.
Ghadeer S
GS
Al-Zaben
Department of Ophthalmology, CHU Fattouma Bourguiba, Monastir, Tunisia.
Moncef
M
Khirallah
Department of Endocrinology, CHU Fattouma Bourguiba, Monastir, Tunisia.
Hela
H
Marmouch
Research Unit of Biology and Genetics of Hematological and Autoimmune diseases, Faculty of Pharmacy of Monastir, University of Monastir, Monastir, Tunisia.
Touhami
T
Mahjoub
Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain. Electronic address: wassim@agu.edu.bh.
Wassim Y
WY
Almawi
D018912:Arabs / Q000235:genetics; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics; D050762:Cyclin-Dependent Kinase Inhibitor p15 / Q000235:genetics; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics; D004256:DNA Polymerase I / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics; D011379:Prognosis; D011506:Proteins / Q000235:genetics*; D012737:Sex Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics; D014416:Tunisia; D000075703:Zinc Transporter 8; D000099161:Kcnj11 Channel
D015415:Biomarkers; D027682:Cation Transport Proteins; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004256:DNA Polymerase I; D024661:Potassium Channels, Inwardly Rectifying; D011506:Proteins; D058118:Transcription Factor 7-Like 2 Protein; D000075703:Zinc Transporter 8; D000099161:Kcnj11 Channel; C493966:CDKN2B protein, human; C492522:SLC30A8 protein, human; C544894:TCF7L2 protein, human
Genetic association studies; Single nucleotide polymorphisms; Type 2 diabetes