Mediastinal fibrosis and positive antineutrophil cytoplasmic antibodies: coincidence or common etiology?
Retroperitoneal fibrosis (RPF) with positive antineutrophil cytoplasmic antibodies (ANCA) has been reported in several cases. We herein present the case of a 52-year-old woman who was diagnosed with mediastinal fibrosis (MF) on a thoracoscopic surgical biopsy. The patient had positive myeloperoxidase ANCA and thereafter developed crescentic glomerulonephritis, which was considered to be a form of ANCA-related nephritis. Both the MF and crescentic glomerulonephritis favorably responded to immunosuppressive therapy. These findings suggest a common pathogenesis of these disorders involving ANCA positivity, as reported in patients with RPF.
Department of Respiratory Medicine and Allergology, Kinki University Faculty of Medicine, Japan.
Hiroshi
H
Santo
Osamu
O
Nishiyama
Hiroyuki
H
Sano
Masanori
M
Kitaichi
Hiroaki
H
Kume
Yuji
Y
Tohda
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D008480:Mediastinitis / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D012598:Sclerosis / Q000097:blood* / Q000175:diagnosis* / Q000209:etiology
D019268:Antibodies, Antineutrophil Cytoplasmic