2-Aminopyridines via reaction of pyridine N-oxides and activated isocyanides.
A practical and efficient method for the synthesis of substituted 2-aminopyridines from pyridine N-oxides is reported. Yields of purified, isolated products of up to 84% are observed for the one-pot, two-step process. The reaction involves an in situ deprotection of an isolable N-formylaminopyridine intermediate and facilitates the synthesis of 2-aminopyridines for which other methods fail.
Cell Death & Survival Networks Program and Conrad Prebys Center for Chemical Genomics, Sanford-Burnham Medical Research Institute , 10901 North Torrey Pines Road, La Jolla, California 92037, United States.
Mitchell
M
Vamos
Nicholas D P
ND
Cosford
D000631:Aminopyridines / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*
D000631:Aminopyridines; D003486:Cyanides; D011725:Pyridines; C013229:pyridine N-oxide; C032439:alpha-aminopyridine