Comparison of adjuvant chemotherapy and radiotherapy in patients with cervical adenocarcinoma of the uterus after radical hysterectomy: SGSG/TGCU Intergroup surveillance.
OBJECTIVE
The authors conducted this retrospective study to evaluate the efficacy of radiotherapy (RT) for high-risk patients with adenocarcinoma (AC) compared with chemotherapy (CT) after radical hysterectomy.


METHODS
There were 263 patients with AC and 58 with adenosquamous cell carcinoma (ASCC). Of these 321 patients, 151 received adjuvant treatment. Of these 151 patients, 69 received radiotherapy (RT) alone, including concurrent chemoradiotherapy (CCRT) with weekly cisdiamminedichloroplatinum (CDDP), 64 patients received CT alone, and 18 patients received concomitant RT and CT (RT + CT).


RESULTS
The five-year overall survival (OS) was 70.9% for patients receiving RT, 79.2% for CT, and 66.2% for RT + CT. Adjuvant treatment did not affect the incidence or the pattern of recurrence. The incidence of lymph node involvement was 9.0% in Stage Ib1, 23.9% in Stage Ib2, 30.8% in Stage IIa, and 41.2% in Stage IIb.


CONCLUSIONS
Adjuvant CT may be effective for high-risk patients with cervical adenocarcinoma.
Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago, Japan. mshima12@med.tottori-u.ac.jp
M
M
Shimada
Department of Gynecology, Hyogo Cancer Center, Akashi, Japan.
R
R
Nishimura
Department of Obstetrics and Gynecology, Kagoshima City Hospital, Kagoshima, Japan.
M
M
Hatae
Department of Gynecology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan.
M
M
Hiura
Department of Obstetrics and Gynecology, National Hospital Organization Kure Medical Center, Kure, Japan.
K
K
Takehara
Department of Gynecology, Miyagi Cancer Center, Natori, Japan.
T
T
Tase
Department of Obstetrics and Gynecology, Fukushima Medical University, Fukushima, Japan.
H
H
Yamada
Department of Obstetrics and Gynecology, Yamagata University, Yamagata, Japan.
H
H
Kurachis
Department of Obstetrics and Gynecology, Iwate Medical University, Morioka, Japan.
T
T
Sugiyama
Department of Cancer Center, Tottori University Hospital, Yonago, Japan.
J
J
Kigawa
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*