[Routine western medicine treatment plus qishen yiqi dripping pill for treating patients with chronic heart failure: a systematic review of randomized control trials].
OBJECTIVE
To systematically review the safety and efficacy of Qishen Yiqi Dripping Pill (QYDP) as a complementary treatment for chronic heart failure (CHF) patients.


METHODS
CNKI, VIP, Wanfang Data, PubMed and Cochrane Library were retrieved for papers on randomized control trials of treating CHF patients by routine western medical treatment plus QYDP. The quality of inclusive literatures was assessed by methods from Cochrane Handbook. Valid data were extracted and analyzed by Meta-analysis using RevMan 5.1.0 Software.


RESULTS
Totally 17 trials and 1840 patients in line with standard were included. Results of Meta-analysis showed, compared with the routine Western medical treatment group, additional use of QYDP could decrease re-admission rate [RR = 0.52, 95% CI (0.33, 0.81), P = 0.004] and the mortality rate, improve the clinical efficacy [RR = 1.18, 95% CI (1.12, 1.25), P < 0.01] and cardiac function [RR = 1.18, 95% CI (1.10, 1.27),P < 0.01], increase left ventricular ejection fraction (LVEF) [WMD = 5.57, 95% CI (4.16, 6.97), P < 0.01] of CHF patients. Subgroup analysis of LVEF showed that additional use of QYDP could further improve LVEF [ WMD = 8.34, 95% CI (6.23, 10.45), P < 0.01] of CHF patients and increase the distance of their 6-min walk test [WMD = 94.39, 95% CI (71.89, 116.89), P < 0.01]. But there was no statistical difference in plasma brain natriuretic peptide (BNP) between the two groups. No obvious adverse reaction and liver or kidney damage was reported during the trial.


CONCLUSIONS
Compared with the Western medical treatment, additional use of QYDP was safe and could further improve clinical efficacy. However, larger and high-quality clinical trials are necessary for further evidence.
School of Graduates, Tianjin University of Traditional Chinese Medicine, Tianjin (300193), China.
Shuan-hu
SH
Wang
Department of Cardiovascular Diseases, The First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin (300193), China.
Jing-yuan
JY
Mao
Department of Cardiovascular Diseases, The First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin (300193), China.
Ya-zhu
YZ
Hou
School of Graduates, Tianjin University of Traditional Chinese Medicine, Tianjin (300193), China.
Jia-ying
JY
Wang
Department of Cardiovascular Diseases, The First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin (300193), China.
Xian-liang
XL
Wang
Department of Cardiovascular Diseases, The First Teaching Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin (300193), China.
Zhi-jun
ZJ
Li
D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic
D004365:Drugs, Chinese Herbal; C528580:qishen yiqi