Regulation of tumor-associated high-endothelial venules by dendritic cells: A new opportunity to promote lymphocyte infiltration into breast cancer?
Accumulating evidence suggests that high-endothelial venules (HEVs) represent major gateways for the infiltration of lymphocytes within neoplastic lesions. However, the origin of these vessels in human neoplasms remains elusive. We have recently discovered a link between lymphotoxin β-producing dendritic cells and tumor-associated HEVs.
CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); Toulouse, France ; Université de Toulouse; UPS; IPBS; Toulouse, France ; Institut Claudius Regaud; Toulouse, France ; Immunology of Cancer and Infection Laboratory; QIMR Berghofer Medical Research Institute; Herston, QLD Australia.
Ludovic
L
Martinet
CNRS; IPBS (Institut de Pharmacologie et de Biologie Structurale); Toulouse, France ; Université de Toulouse; UPS; IPBS; Toulouse, France.
Jean-Philippe
JP
Girard
HEV; blood vessels; breast cancer; dendritic cells; lymphocytes