Biomarkers as outcome predictors in subarachnoid hemorrhage--a systematic review.
BACKGROUND
Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome.


OBJECTIVE
The aim of this review was to summarize biomarkers of SAH associated with outcome.


METHODS
An electronic database query was completed, including an additional review of reference lists to include all potential human studies.


RESULTS
A total of 298 articles were identified; 112 were reviewed; 55 studies were included.


CONCLUSIONS
This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.
Department of Anesthesiology, Division of Critical Care Medicine .
Caron M
CM
Hong
Cigdem
C
Tosun
David B
DB
Kurland
Volodymyr
V
Gerzanich
David
D
Schreibman
J Marc
JM
Simard
D000818:Animals; D015415:Biomarkers / Q000097:blood; D006801:Humans; D011379:Prognosis; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome
D015415:Biomarkers