Evaluation of the morphological changes of gastric mucosa induced by a low concentration of acetic acid using a rat model.
Oral ingestion of concentrated acetic acid causes corrosive injury of the gastrointestinal tract. To assess the effects of a low concentration of acetic acid on gastric mucosa, we examined the gastric mucosal changes in rats at 1 and 3 days after the injection of 5% or 25% acetic acid into the gastric lumen. The area of the gastric ulcerative lesions in the 25% acetic acid group was significantly larger than that in the 5% acetic acid group. The lesion area was reduced significantly at 3 days after injection in the 5% acetic acid group, whereas no significant difference in lesion area was observed at 1 and 3 days in the 25% acetic acid group. Histologically, corrosive necrosis was limited to the mucosal layer in the 5% acetic acid group, whereas necrosis extended throughout the gastric wall in the 25% acetic acid group. At 3 days post-injection, the 25% acetic acid group showed widespread persistent inflammation, whereas the 5% acetic acid group showed widespread appearance of fibroblasts indicative of a healing process. These results indicate that a low concentration of acetic acid damages the gastric mucosa and that the degree of mucosal damage depends on the concentration of acetic acid.
Department of Legal Medicine, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address: knakao55@research.twmu.ac.jp.
Ken-ichiro
K
Nakao
Department of Legal Medicine, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address: chaeja@research.twmu.ac.jp.
Ayako
A
Ro
Department of Legal Medicine, School of Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. Electronic address: kibayash@research.twmu.ac.jp.
Kazuhiko
K
Kibayashi
D019342:Acetic Acid / Q000633:toxicity*; D000818:Animals; D002057:Burns, Chemical / Q000473:pathology*; D002424:Caustics / Q000633:toxicity*; D005347:Fibroblasts / Q000473:pathology; D049429:Forensic Pathology; D005753:Gastric Mucosa / Q000473:pathology*; D008297:Male; D023421:Models, Animal; D009336:Necrosis; D009504:Neutrophils / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000473:pathology
D002424:Caustics; D019342:Acetic Acid
Accident; Acetic acid; Gastric ulcer; Ingestion