Biodegradation of veterinary ionophore antibiotics in broiler litter and soil microcosms.
Ionophore antibiotics (IPAs) are polyether compounds used in broiler feed to promote growth and control coccidiosis. Most of the ingested IPAs are excreted into broiler litter (BL), a mixture of excreta and bedding material. BL is considered a major source of IPAs released into the environment as BL is commonly used to fertilize agricultural fields. This study investigated IPA biodegradation in BL and soil microcosms, as a process affecting the fate of IPAs in the environment. The study focused on the most widely used IPAs, monensin (MON), salinomycin (SAL), and narasin (NAR). MON was stable in BL microcosms at 24-72% water content (water/wet litter, w/w) and 35-60 °C, whereas SAL and NAR degraded under certain conditions. Factor analysis was conducted to delineate the interaction of water and temperature on SAL and NAR degradation in the BL. A major transformation product of SAL and NAR was identified. Abiotic reaction(s) were primarily responsible for the degradation of MON and SAL in nonfertilized soil microcosms, whereas biodegradation contributed significantly in BL-fertilized soil microcosms. SAL biotransformation in soil microcosms yielded the same product as in the BL microcosms. A new primary biotransformation product of MON was identified in soil microcosms. A field study showed that MON and SAL were stable during BL stacking, whereas MON degraded after BL was applied to grassland. The biotransformation product of MON was also detected in the top soil layer where BL was applied.
School of Civil and Environmental Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332, United States.
Peizhe
P
Sun
Miguel L
ML
Cabrera
Ching-Hua
CH
Huang
Spyros G
SG
Pavlostathis
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D001673:Biodegradation, Environmental; D002645:Chickens; D005308:Fertilizers; D007476:Ionophores / Q000493:pharmacokinetics; D008372:Manure; D008985:Monensin / Q000493:pharmacokinetics; D011714:Pyrans / Q000493:pharmacokinetics; D012988:Soil Microbiology; D012989:Soil Pollutants / Q000493:pharmacokinetics*; D013696:Temperature; D019155:Veterinary Drugs / Q000493:pharmacokinetics; D014867:Water; D000095662:Polyether Polyketides
D000900:Anti-Bacterial Agents; D005308:Fertilizers; D007476:Ionophores; D008372:Manure; D008985:Monensin; D011714:Pyrans; D012989:Soil Pollutants; D019155:Veterinary Drugs; D014867:Water; C010327:salinomycin; D000095662:Polyether Polyketides; C013612:narasin