Importance of the neutrophil-to-lymphocyte ratio in muscle-invasive and non-muscle invasive bladder tumors.
BACKGROUND
To research the importance of the neutrophil-to-lymphocyte ratio (NLR) in muscle-invasive bladder cancers (MIBC) and non-muscle invasive bladder cancer (NMIBC).


METHODS
Data of 198 patients who underwent TUR-TM in our clinic were retrospectively evaluated. Patients were divided into two groups: group-I (MIBC) and group-II (NMIBC). The neutrophil and lymphocyte counts, NLR, hemoglobin and hematocrit values, tumor numbers, sizes and degrees of patients were recorded. Within the inter-group comparison, Mann-Whitney U test was used for the values stated with measuring, whereas a Chi-square test was used for the values stated with counting. The cut-off value for the NLR was determined with ROC curve.


RESULTS
The NLR values of group-I and group-II were found as 4.14 ± 2.76 and 3.36 ± 2.88, respectively (p = 0.03). Whether the NLR carries a differential property was evaluated with ROC curve. The cut-off value was estimated as 3.96 according to the Youden index. With this value, sensitivity was found as 50%, specificity was 22.8% and AUC was 0.615 (p = 0.03).


CONCLUSIONS
According to the data in this study, it can be said that Ta-T1 tumors are likely to be invasive by 50% if the NLR value is greater than 3.96.
Department of Urology Clinic of Yüksek Ihtisas Training and Research Hospital, Ankara - Turkey.
Cavit
C
Ceylan
Omer G
OG
Doluoglu
Ibrahim
I
Keleş
Eymen
E
Gazel
Tülay
T
Temuçin
Öner
Ö
Odabaş
Mustafa
M
Karalar
D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000276:immunology / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D018655:Lymphocyte Count; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000276:immunology*; D009367:Neoplasm Staging; D020556:Neutrophil Infiltration; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D001749:Urinary Bladder Neoplasms / Q000276:immunology / Q000473:pathology*