MicroRNAs and SerpinB3 in hepatocellular carcinoma.
miRNAs are small non-coding RNAs which target complementary mRNA sequences, usually resulting in gene silencing. They can exhibit oncogenic or tumor suppressor properties, modulating cell homeostasis. Several data have documented that miRNAs are typically deregulated in different types of cancers, including hepatocellular carcinoma (HCC). Some of the miRNAs such as miR-122, miR-221, miR-1 and miR-21 have been found to repress post-transcriptionally the expression of genes involved in cell cycle regulation, cell proliferation, apoptosis, cell migration and invasion. In HCC serum levels of miR-122, miR-221 and miR-16 have been described deregulated, suggesting that they may be used as molecular targets for early detection, prognosis and treatment. The ov-serpin SerpinB3 was found previously increased in liver tumor cancers and associated with apoptosis resistance, increased cell proliferation and invasiveness. Recent data indicate that this serpin may enhance its oncogenic potential through inhibition of several tumor suppressive miRNAs, typically described in HCC.
Department of Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy.
Cristian
C
Turato
Department of Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy.
Davide
D
Simonato
Department of Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy.
Santina
S
Quarta
Department of Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy.
Angelo
A
Gatta
Department of Medicine, University of Padua, Via Giustiniani, 2, 35128 Padua, Italy. Electronic address: patrizia@unipd.it.
Patrizia
P
Pontisso
D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics* / Q000378:metabolism; D001483:Base Sequence; D006528:Carcinoma, Hepatocellular; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008113:Liver Neoplasms; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D034622:RNA Interference; D012323:RNA Processing, Post-Transcriptional; D015843:Serpins / Q000235:genetics* / Q000378:metabolism
D000951:Antigens, Neoplasm; D035683:MicroRNAs; D015843:Serpins; C051072:squamous cell carcinoma-related antigen
Primary liver cancer; SerpinB3; Small non coding RNA