Low-frequency stimulation of dorsal norephinephrine bundle reverses behavioral long-term potentiation and learning performance in rats.
Dorsal norepinephrine bundle (DNEB) is the major source of noradrenergic input to the hippocampus and norepinephrine could regulate long-term potentiation (LTP) reversal. In the present study, we investigated the effects of low-frequency stimulation (LFS) of DNEB on behavioral LTP and Y-maze learning task, by using electrophysiological recording in freely moving rats combined with behavioral tests. We found that LFS on DNEB, including 1 and 5Hz, could inhibit reversibly basal synaptic transmission within 100-min recordings in hippocampal perforant path projections to dentate gyrus (PP-DG) pathway. 1-Hz stimulating DNEB, delivered 5min after the daily training session, reverses behavioral LTP completely and depresses the behavioral learning as well. However, 5-Hz-treated only reverses behavioral LTP partially and reduces the behavioral learning accordingly. These results indicate that behavioral LTP in PP-DG pathway can be reversed by LFS on DNEB, and display a similar impact on Y-maze learning performance. Our data provide a new characterization of LTP reversibility and will ultimately be helpful in understanding how new information is to detect and determine storage in the hippocampus.
School of Life Science, South China Normal University, Guangzhou 510631, China.
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Yan
Department of Urology, PLA General Hospital, 28 Fuxing Road, Beijing 100853, China.
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Wang
School of Life Science, South China Normal University, Guangzhou 510631, China.
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Zeng
School of Life Science, South China Normal University, Guangzhou 510631, China.
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Liu
School of Life Science, South China Normal University, Guangzhou 510631, China.
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Xu
School of Life Science, South China Normal University, Guangzhou 510631, China.
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Liu
School of Life Science, South China Normal University, Guangzhou 510631, China. Electronic address: xiaopeng@scnu.edu.cn.
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Xiao
School of Life Science, South China Normal University, Guangzhou 510631, China. Electronic address: lich@scnu.edu.cn.
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Li
D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D009638:Norepinephrine
LTP reversal; behavioral LTP; dorsal norepinephrine bundle; low-frequency stimulation; maze learning task