Evaluation of alternative rapid thin layer chromatography systems for quality control of technetium-99m radiopharmaceuticals.
Whatman 3MM™ and Tec-Control™ systems were evaluated as ITLC-SG alternatives for 99mTc-radiopharmaceuticals. They compare well in accuracy and reproducibility, and are faster and more convenient than ITLC-SG. Tec-Control™ radiochemical purity values for 99mTc-sestamibi were more conservative than ITLC-SG. Full solvent migration was not reproduced for 99mTc-tetrofosmin in Tec-Control™, and for this Whatman 3MM™ is preferred. Developing times were 10-15 min, 7-9 min and ~1min for ITLC-SG, Whatman 3MM™ and Tec-Control™, respectively. Overall, Tec-Control™ strips are preferred due to speed and ease of use.
Radiopharmacy, Health Sciences Centre, GC219-820 Sherbrook Street, Winnipeg, MB, Canada R3A1R9,; Radiology, Faculty of Medicine, University of Manitoba, GA216-820 Sherbrook Street, Winnipeg, MB, Canada R3T 2N2; Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5. Electronic address: kmangera@hsc.mb.ca.
Kennedy
K
Mang'era
Radiopharmacy, Health Sciences Centre, GC219-820 Sherbrook Street, Winnipeg, MB, Canada R3A1R9,; Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5.
Derek
D
Wong
Radiology, Faculty of Medicine, University of Manitoba, GA216-820 Sherbrook Street, Winnipeg, MB, Canada R3T 2N2.
David
D
Douglas
Radiopharmacy, Health Sciences Centre, GC219-820 Sherbrook Street, Winnipeg, MB, Canada R3A1R9.
Kellie
K
Franz
Radiopharmacy, Health Sciences Centre, GC219-820 Sherbrook Street, Winnipeg, MB, Canada R3A1R9.
Taddese
T
Biru
D000965:Antimony / Q000302:isolation & purification; D002855:Chromatography, Thin Layer / Q000379:methods*; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000737:chemistry; D015203:Reproducibility of Results; D013440:Sulfides / Q000302:isolation & purification; D013667:Technetium / Q000302:isolation & purification*; D013669:Technetium Tc 99m Medronate / Q000302:isolation & purification; D017256:Technetium Tc 99m Sestamibi / Q000302:isolation & purification; D013671:Technetium Tc 99m Sulfur Colloid / Q000302:isolation & purification
D019275:Radiopharmaceuticals; D013440:Sulfides; D013671:Technetium Tc 99m Sulfur Colloid; D013667:Technetium; D017256:Technetium Tc 99m Sestamibi; D000965:Antimony; C064234:antimony trisulfide; D013669:Technetium Tc 99m Medronate
ITLC-SG; Quality control; Radiopharmaceuticals; Tec-Control™; Technetium; Whatman 3MM™