Organometallic carbonyl clusters: a new class of contrast agents for photoacoustic cerebral vascular imaging.
We report, for the first time, the use of a water-soluble organometallic compound as a stable, reliable and high-contrast photoacoustic contrast agent. This gives a significantly higher contrast than that achievable with alternatives such as single-walled carbon nanotubes. Image enhancement of the rat cerebral cortex vasculature was observed using in vivo dark-field photoacoustic microscopy.
Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore. malini_olivo@sbic.a-star.edu.sg.
Kien Voon
KV
Kong
Lun-De
LD
Liao
Zhiyong
Z
Lam
Nitish V
NV
Thakor
Weng Kee
WK
Leong
Malini
M
Olivo
D000818:Animals; D002560:Cerebrovascular Circulation; D003287:Contrast Media / Q000737:chemistry*; D015394:Molecular Structure; D059906:Neuroimaging; D009942:Organometallic Compounds / Q000737:chemistry*; D009992:Osmium / Q000737:chemistry*; D061088:Photoacoustic Techniques; D051381:Rats; D012995:Solubility; D014867:Water / Q000737:chemistry*
D003287:Contrast Media; D009942:Organometallic Compounds; D014867:Water; D009992:Osmium