Interaction relationships of osteoarthritis and rheumatoid arthritis related genes.
BACKGROUND
Osteoarthritis (OA), also referred to as degenerative joint disease or wear-and-tear arthritis, is caused by the breakdown of joint cartilage. Rheumatoid arthritis (RA) is a chronic, inflammatory type of arthritis. RA is also classified as a kind of autoimmune disease.


OBJECTIVE
To find the important genes in RA and OA.


METHODS
Comprehensively compared 3 datasets of RA with 2 datasets of OA, 98 genes were sifted. We explored protein-protein associations processed for the 98 genes by mining famous gene/protein interaction/association database.


RESULTS
We found most of those genes appear to play a key role in the anti-inflammatory and immunosuppressive effects.


CONCLUSIONS
Our research would play a useful role in the diagnosis and treatment of OA and RA.
Orthopedics Department, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China. chengbiaobiao@hotmail.com  
Q
Q
Zhang
B
B
Cheng
C-X
CX
Yang
H-A
HA
Ge
D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000378:metabolism; D001327:Autoimmune Diseases / Q000235:genetics / Q000378:metabolism; D002358:Cartilage, Articular / Q000378:metabolism; D006801:Humans; D010003:Osteoarthritis / Q000235:genetics* / Q000378:metabolism; D060066:Protein Interaction Maps / Q000235:genetics; D059467:Transcriptome / Q000235:genetics