Water-soluble vitamin deficiencies in complicated peptic ulcer patients soon after ulcer onset in Japan.
We investigated over time whether contemporary Japanese patients with complicated peptic ulcers have any water-soluble vitamin deficiencies soon after the onset of the complicated peptic ulcers. In this prospective cohort study, fasting serum levels of water-soluble vitamins (vitamins B1, B2, B6, B12, C, and folic acid) and homocysteine were measured at 3 time points (at admission, hospital discharge, and 3 mo after hospital discharge). Among the 20 patients who were enrolled in the study, 10 consecutive patients who completed measurements at all 3 time points were analyzed. The proportion of patients in whom any of the serum water-soluble vitamins that we examined were deficient was as high as 80% at admission, and remained at 70% at discharge. The proportion of patients with vitamin B6 deficiency was significantly higher at admission and discharge (50% and 60%, respectively, p<0.05) than at 3 mo after discharge (10%). In conclusion, most patients with complicated peptic ulcers may have a deficiency of one or more water-soluble vitamins in the early phase of the disease after the onset of ulcer complications, even in a contemporary Japanese population.
Department of Gastroenterology, Nippon Medical School.
Kazumasa
K
Miyake
Teppei
T
Akimoto
Makoto
M
Kusakabe
Wataru
W
Sato
Akiyoshi
A
Yamada
Hiroshi
H
Yamawaki
Yasuhiro
Y
Kodaka
Mayumi
M
Shinpuku
Hiroyuki
H
Nagoya
Tomotaka
T
Shindo
Nobue
N
Ueki
Masafumi
M
Kusunoki
Tetsuro
T
Kawagoe
Seiji
S
Futagami
Taku
T
Tsukui
Choitsu
C
Sakamoto
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001205:Ascorbic Acid / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D005492:Folic Acid / Q000097:blood; D005500:Follow-Up Studies; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000097:blood* / Q000150:complications; D011446:Prospective Studies; D012256:Riboflavin / Q000097:blood; D013831:Thiamine / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood; D025101:Vitamin B 6 / Q000097:blood; D014803:Vitamin B Complex / Q000097:blood*; D014804:Vitamin B Deficiency / Q000097:blood* / Q000150:complications
D006710:Homocysteine; D014803:Vitamin B Complex; D025101:Vitamin B 6; D005492:Folic Acid; D014805:Vitamin B 12; D001205:Ascorbic Acid; D012256:Riboflavin; D013831:Thiamine