Global gene expression distribution in non-cancerous complex diseases.
For gene expression in non-cancerous complex diseases, we systemically evaluated the sensitivities of biological discoveries to violation of the common normalization assumption. Our results indicated that gene expression may be widely up-regulated in digestive system and musculoskeletal diseases. However, global signal intensities showed little difference in other four disease types.
College of Bioinformatics Science and Technology, the Fourth Affiliated Hospital, Harbin Medical University, 157 Baojian Road, Harbin, China. wangdong@ems.hrbmu.edu.cn kongningli@hotmail.com zhuangliweiyd@126.com.
Yun
Y
Wu
Nana
N
Jin
Haiyang
H
Zhu
Chunmiao
C
Li
Nannan
N
Liu
Yan
Y
Huang
Zhengqiang
Z
Miao
Xiaoman
X
Bi
Deng
D
Wu
Xi
X
Chen
Yun
Y
Xiao
Dapeng
D
Hao
Chuanxing
C
Li
Binsheng
B
Gong
Shaojun
S
Zhang
Liwei
L
Zhuang
Kongning
K
Li
Dong
D
Wang
D030562:Databases, Protein; D005260:Female; D052776:Female Urogenital Diseases / Q000235:genetics; D005767:Gastrointestinal Diseases / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D009140:Musculoskeletal Diseases / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics; D012140:Respiratory Tract Diseases / Q000235:genetics; D012871:Skin Diseases / Q000235:genetics; D059467:Transcriptome