MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6).
Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa.
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Department of Urology, Xuzhou Central Hospital Affiliated with Southeast University, Xuzhou, Jiangsu Province 221009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
Dachuang
D
Liu
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
Tao
T
Tao
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
Bin
B
Xu
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
Shuqiu
S
Chen
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
Chunhui
C
Liu
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China.
Lei
L
Zhang
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China.
Kai
K
Lu
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
Yeqing
Y
Huang
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
Liang
L
Jiang
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China.
Xiaowen
X
Zhang
Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China.
Xiaoming
X
Huang
Department of Pathology, Zhongda Hospital Affiliated with Southeast University, Nanjing, Jiangsu Province 210009, China.
Lihua
L
Zhang
Department of Urology, Xuzhou Central Hospital Affiliated with Southeast University, Xuzhou, Jiangsu Province 221009, China.
Conghui
C
Han
Department of Urology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province 210009, China; Surgery Central Laboratory of Southeast University, Nanjing, Jiangsu Province 210009, China. Electronic address: mingchenseu@gmail.com.
Ming
M
Chen
D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D015153:Blotting, Western; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics*; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D064129:Prostatic Neoplasms, Castration-Resistant / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D034622:RNA Interference; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050800:STAT6 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D023041:Xenograft Model Antitumor Assays; D051020:bcl-X Protein / Q000235:genetics / Q000378:metabolism
D020413:3' Untranslated Regions; C575475:MIRN361 microRNA, human; D035683:MicroRNAs; D050800:STAT6 Transcription Factor; D025521:Tumor Suppressor Proteins; D051020:bcl-X Protein
Bcl-xL; Castration-resistant prostate cancer (CRPC); STAT6; miR-361-5p