The disease burden of hepatitis B, influenza, measles and salmonellosis in Germany: first results of the burden of communicable diseases in Europe study.
Setting priorities in the field of infectious diseases requires evidence-based and robust baseline estimates of disease burden. Therefore, the European Centre for Disease Prevention and Control initiated the Burden of Communicable Diseases in Europe (BCoDE) project. The project uses an incidence- and pathogen-based approach to measure the impact of both acute illness and sequelae of infectious diseases expressed in disability-adjusted life years (DALYs). This study presents first estimates of disease burden for four pathogens in Germany. The number of reported incident cases adjusted for underestimation served as model input. For the study period 2005-2007, the average disease burden was estimated at 33 116 DALYs/year for influenza virus, 19 115 DALYs/year for Salmonella spp., 8708 DALYs/year for hepatitis B virus and 740 DALYs/year for measles virus. This methodology highlights the importance of sequelae, particularly for hepatitis B and salmonellosis, because if omitted, the burden would have been underestimated by 98% and 56%, respectively.
Department of Public Health Medicine, School of Public Health,University of Bielefeld,Bielefeld,Germany.
D
D
Plass
University Medical Centre Utrecht (UMCU),Utrecht,The Netherlands.
M-J J
MJ
Mangen
Department of Public Health Medicine, School of Public Health,University of Bielefeld,Bielefeld,Germany.
A
A
Kraemer
Department of Public Health Medicine, School of Public Health,University of Bielefeld,Bielefeld,Germany.
P
P
Pinheiro
Robert Koch Institute,Berlin,Germany.
A
A
Gilsdorf
Robert Koch Institute,Berlin,Germany.
G
G
Krause
Institute of Evolutionary Biology,University of Edinburgh,Edinburgh, Scotland,UK.
C L
CL
Gibbons
National Institute for Public Health and the Environment (RIVM),Centre for Infectious Disease Control, Bilthoven,The Netherlands.
A
A
VAN Lier
National Institute for Public Health and the Environment (RIVM),Centre for Infectious Disease Control, Bilthoven,The Netherlands.
S A
SA
McDONALD
University Medical Centre Utrecht (UMCU),Utrecht,The Netherlands.
R J
RJ
Brooke
European Centre for Disease Prevention and Control (ECDC), Stockholm,Sweden.
P
P
Kramarz
European Centre for Disease Prevention and Control (ECDC), Stockholm,Sweden.
A
A
Cassini
University Medical Centre Utrecht (UMCU),Utrecht,The Netherlands.
M E E
ME
Kretzschmar
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005858:Germany / Q000453:epidemiology; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology*; D019694:Hepatitis B, Chronic / Q000150:complications / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007251:Influenza, Human / Q000150:complications / Q000453:epidemiology*; D017114:Liver Failure, Acute / Q000453:epidemiology / Q000209:etiology; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008457:Measles / Q000453:epidemiology*; D008875:Middle Aged; D019057:Quality-Adjusted Life Years; D012128:Respiratory Distress Syndrome / Q000453:epidemiology / Q000209:etiology; D012480:Salmonella Infections / Q000453:epidemiology*; D055815:Young Adult