Principles of modern solid-phase oligosaccharide synthesis.
The past few decades have seen a renewed interest in the chemical synthesis of oligosaccharides, owing to increased recognition of their biological importance. Of the different approaches to oligosaccharides, solid-phase synthesis has emerged as a particularly attractive option, due in large part to its potential for automation. This perspective describes principles to consider when planning solid-phase oligosaccharide synthesis (SPOS), including recent achievements and areas where future work is necessary.
Department of Chemistry, Tufts University, 62 Talbot Ave., Medford, MA, USA. clay.bennett@tufts.edu.
Clay S
CS
Bennett
D001704:Biopolymers / Q000737:chemistry; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006801:Humans; D009844:Oligosaccharides / Q000737:chemistry*
D001704:Biopolymers; D009844:Oligosaccharides