Reversible hepatic decompensation following cessation of antiretroviral therapy in a patient with HIV and hepatitis C co-infection.
We report the case of 47-year-old man with HIV and hepatitis C virus-associated cirrhosis who, following discontinuation of his antiretroviral therapy (ART), rapidly developed hepatic decompensation. On restarting his ART there was a noticeable improvement in his liver function, which was attributed to regaining good HIV virus control. Further data on the effects of restarting ART after ART cessation-associated hepatic decompensation are needed.
St Mary's Hospital, London, UK a.croucher@imperial.ac.uk.
Adam P
AP
Croucher
St Mary's Hospital, London, UK.
Janice
J
Main
D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D001706:Biopsy; D060085:Coinfection; D018450:Disease Progression; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy* / Q000821:virology; D016174:Hepacivirus / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008297:Male; D055118:Medication Adherence; D008875:Middle Aged; D016896:Treatment Outcome; D019562:Viral Load
D044966:Anti-Retroviral Agents
AIDS; HIV; antiretroviral therapy; cirrhosis; hepatic decompensation; hepatitis C; treatment cessation