Neem gum as a binder in a formulated paracetamol tablet with reference to Acacia gum BP.
This study determined the physical, compressional, and binding properties of neem gum (NMG) obtained from the trunk of Azadirachta indica (A Juss) in a paracetamol tablet formulation in comparison with official Acacia gum BP (ACA). The physical and flow properties were evaluated using density parameters: porosity, Carr's index, Hausner's ratio, and flow rate. Compressional properties were analyzed using Heckel and Kawakita equations. The tensile strength, brittle fracture index, and crushing strength-friability/disintegration time ratio were used to evaluate the mechanical properties of paracetamol tablets while the drug release properties of the tablets were assessed using disintegration time and dissolution times. Tablet formulations containing NMG exhibited faster onset and higher amount of plastic deformation during compression than those containing ACA. Neem gum produced paracetamol tablets with lower mechanical strength; however, the tendency of the tablets to cap or laminate was lower when compared to those containing ACA. Inclusion of NMG improved the balance between binding and disintegration properties of paracetamol tablets produced than those containing ACA. Neem gum produced paracetamol tablets with lower disintegration and dissolution times than those containing ACA.
Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria, ohtolu@gmail.com.
Abayomi Tolulope
AT
Ogunjimi
Gbenga
G
Alebiowu
D000082:Acetaminophen / Q000737:chemistry*; D031601:Azadirachta / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D006170:Gum Arabic / Q000737:chemistry*; D013607:Tablets
D013607:Tablets; D000082:Acetaminophen; D006170:Gum Arabic