Molecular typing methods for minor histocompatibility antigens.
Minor histocompatibility (H) antigen mismatching leads to clinically relevant alloimmune reactivity. Depending on the tissue expression pattern of the involved minor H antigens, the immune response may either cause graft-versus-host disease and a graft-versus-tumor effect or lead to only a graft-versus-leukemia effect. Thus, identification of recipient-donor pairs with minor H antigen mismatches has clinical importance. This chapter describes molecular typing methods for molecular typing of minor H antigens.
Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Eric
E
Spierings
D000483:Alleles; D002877:Chromosomes, Human; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D058889:Molecular Typing / Q000379:methods*; D016133:Polymerase Chain Reaction / Q000379:methods; D012150:Polymorphism, Restriction Fragment Length; D017422:Sequence Analysis, DNA / Q000379:methods
D015778:Minor Histocompatibility Antigens