Recent advances in chelator design and labelling methodology for (68) Ga radiopharmaceuticals.
Gallium-68 has the potential to become the technetium-99m of positron emission tomography with ideal decay characteristics and a long-lived parent isotope for generator production. The work in the area of (68) Ga is focused on two key areas: (1) synthesis of a library of bifunctional chelators, which can be quickly radiolabelled to form kinetically inert complexes under mild conditions compatible with biomolecules and (2) development of radiosynthetic methodologies for clinical use and to facilitate radiolabelling of a wide range of chelators under mild conditions. Recent advances in these areas, with particular focus on the past 3 years, are covered herein.
Department of Chemistry, University of Hull, Hull, HU6 7RX, UK; Positron Emission Tomography Research Centre, University of Hull, Hull, HU6 7RX, UK.
Benjamin P
BP
Burke
Gonçalo S
GS
Clemente
Stephen J
SJ
Archibald
D002614:Chelating Agents / Q000737:chemistry*; D015195:Drug Design; D005710:Gallium Radioisotopes / Q000737:chemistry; D007553:Isotope Labeling / Q000379:methods*; D047028:Macrocyclic Compounds / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000737:chemistry*
D002614:Chelating Agents; D005710:Gallium Radioisotopes; D047028:Macrocyclic Compounds; D019275:Radiopharmaceuticals
chelator; gallium-68; macrocycle; positron emission tomography; radiopharmaceutical