Inherited thrombophilias and adverse pregnancy outcomes: a review of screening patterns and recommendations.
Historically, much controversy has existed regarding the association of inherited thrombophilias with adverse pregnancy outcomes. The current guidelines do not recommend screening unless a personal history of venous thromboembolism is present, but the authors' survey of physician screening patterns has suggested that up to 40% of physicians may screen contrary to the current guidelines. This article summarizes the existing evidence for each inherited thrombophilia and reviews the current guidelines.
Department of Obstetrics and Gynecology, University of Vermont, 89 Beaumont Avenue, Given C262, Burlington, VT 05406, USA.
William B
WB
Davenport
Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Fertility Associates of Memphis, 80 Humphreys Center, Suite 307, Memphis, TN 38120, USA. Electronic address: wkutteh@fertilitymemphis.com.
William H
WH
Kutteh
D000026:Abortion, Habitual / Q000097:blood / Q000209:etiology / Q000235:genetics*; D017153:Antibodies, Anticardiolipin / Q000097:blood; D005165:Factor V / Q000235:genetics; D005260:Female; D005317:Fetal Growth Retardation; D005820:Genetic Testing; D019983:Guideline Adherence; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009154:Mutation; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D011225:Pre-Eclampsia / Q000097:blood / Q000209:etiology / Q000235:genetics*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000235:genetics*; D011256:Pregnancy Outcome; D020151:Protein C Deficiency / Q000150:complications; D018455:Protein S Deficiency / Q000150:complications; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood / Q000150:complications / Q000235:genetics*; D054556:Venous Thromboembolism / Q000097:blood / Q000209:etiology / Q000235:genetics*
D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)
Inherited thrombophilias; Intrauterine growth restriction; OB/GYN; Placental abruption; Preeclampsia; Pregnancy; Recurrent pregnancy loss