Mid-infrared, long wave infrared (4-12 μm) molecular emission signatures from pharmaceuticals using laser-induced breakdown spectroscopy (LIBS).
In an effort to augment the atomic emission spectra of conventional laser-induced breakdown spectroscopy (LIBS) and to provide an increase in selectivity, mid-wave to long-wave infrared (IR), LIBS studies were performed on several organic pharmaceuticals. Laser-induced breakdown spectroscopy signature molecular emissions of target organic compounds are observed for the first time in the IR fingerprint spectral region between 4-12 μm. The IR emission spectra of select organic pharmaceuticals closely correlate with their respective standard Fourier transform infrared spectra. Intact and/or fragment sample molecular species evidently survive the LIBS event. The combination of atomic emission signatures derived from conventional ultraviolet-visible-near-infrared LIBS with fingerprints of intact molecular entities determined from IR LIBS promises to be a powerful tool for chemical detection.
Battelle Eastern Science and Technology Center, Aberdeen, MD 21001 USA.
Clayton S-C
CS
Yang
Ei E
EE
Brown
Eric
E
Kumi-Barimah
Uwe H
UH
Hommerich
Feng
F
Jin
Sudhir B
SB
Trivedi
Alan C
AC
Samuels
A Peter
AP
Snyder
D001241:Aspirin / Q000737:chemistry; D004867:Equipment Design; D007834:Lasers; D008956:Models, Chemical; D009930:Organic Chemicals / Q000032:analysis / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000737:chemistry*; D013055:Spectrophotometry, Infrared / Q000295:instrumentation / Q000379:methods*
D009930:Organic Chemicals; D004364:Pharmaceutical Preparations; D001241:Aspirin