Bonding of synthetic hydrogels with fibrin as the glue to engineer hydrogel-based biodevices.
We show the fibrous protein fibrin can serve as biocompatible glue with which to bind synthetic cationic or anionic hydrogels together. Both the bonding to and detachment from the hydrogels by fibrin (gelation and degradation, respectively) proceeded enzymatically under physiological conditions. We built a hydrogel-based actuator to demonstrate the method.
Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai 980-8579, Japan; JST-CREST, Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan.
Kuniaki
K
Nagamine
Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai 980-8579, Japan.
Kohei
K
Okamoto
Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai 980-8579, Japan; JST-CREST, Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan.
Hirokazu
H
Kaji
Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki, Aoba-ku, Sendai 980-8579, Japan; JST-CREST, Sanbancho, Chiyoda-ku, Tokyo 102-0075, Japan. Electronic address: nishizawa@biomems.mech.tohoku.ac.jp.
Matsuhiko
M
Nishizawa
D000269:Adhesives; D001672:Biocompatible Materials / Q000737:chemistry*; D005337:Fibrin / Q000737:chemistry*; D020100:Hydrogels / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*
D000269:Adhesives; D001672:Biocompatible Materials; D020100:Hydrogels; D005337:Fibrin
Biocompatible glue; Fibrin; Hydrogel-based biodevice; Tissue engineering; Wet adhesion technique