Functional properties of ion channels and transporters in tumour vascularization.
Vascularization is crucial for solid tumour growth and invasion, providing metabolic support and sustaining metastatic dissemination. It is now accepted that ion channels and transporters play a significant role in driving the cancer growth at all stages. They may represent novel therapeutic, diagnostic and prognostic targets for anti-cancer therapies. On the other hand, although the expression and role of ion channels and transporters in the vascular endothelium is well recognized and subject of recent reviews, only recently has their involvement in tumour vascularization been recognized. Here, we review the current literature on ion channels and transporters directly involved in the angiogenic process. Particular interest will be focused on tumour angiogenesis in vivo as well as in the different steps that drive this process in vitro, such as endothelial cell proliferation, migration, adhesion and tubulogenesis. Moreover, we compare the 'transportome' system of tumour vascular network with the physiological one.
Department of Life Sciences and Systems Biology, Center for Complex Systems in Molecular Biology and Medicine (SysBioM), Nanostructured Interfaces and Surfaces Centre of Excellence (NIS), University of Torino, , Via Accademia Albertina 13, Torino 10123, Italy.
Alessandra
A
Fiorio Pla
Luca
L
Munaron
D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D017136:Ion Transport / Q000502:physiology*; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D011978:Receptors, Nicotinic / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D007473:Ion Channels; D011978:Receptors, Nicotinic
aquaporins; endothelial cells; ion channels; transporters; tumour vascularization