[Light-isotope water as a therapeutic agent for acute radiation disease].
Eighty outbred CD-I male and female mice (initial body mass of 31-34 g) and 40 male Wistar rats (initial body mass of 280-360 g) were randomly distributed into the experimental and control groups by sex and body mass. According to the results of experiments, consumption of rectified light-isotope water over 30 days immediately after irradiation by gamma-quanta 60Co at 5 Gy and 6.5 Gy can increase survivability rate significantly, accelerate hemopoiesis recovery and prevent body mass loss in irradiated animals. Therefore, light-isotope water can be considered as an effective agent for treatment of the bone marrow syndrome.
A A
AA
Ivanov
I B
IB
Ushakov
E I
EI
Kulikova
D M
DM
Kriuchkova
Iu S
IuS
Severiukhin
S V
SV
Vorozhtsova
A N
AN
Abrosimova
V A
VA
Gaevskiĭ
Iu E
IuE
Siniak
A I
AI
Grigor'ev
D000208:Acute Disease; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D007554:Isotopes / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000532:radiotherapy*; D051381:Rats; D017208:Rats, Wistar; D014867:Water / Q000494:pharmacology*
D007554:Isotopes; D014867:Water