[Effect of Dendrobium officinale granule on long-term-alcohol-induced hypertension rats].
OBJECTIVE
To observe the effect of Dendrobium officinale granule (DOG) on symptoms, blood pressure and serum biochemical indexes of long-term-alcohol-induced hypertension rats.


METHODS
The alcohol-induced hypertension rat model was established by feeding alcohol drink to normal rats (the alcohol volume fraction increases from 5% to 22%). Since the 4th week, DOG was administered for 32 weeks, once everyday. During the experiment, body weight, kinematic parameters (locomotor activities, grip strength, duration of vertigo) and blood pressures (systolic blood pressure, diastolic blood pressure and mean blood pressure) were detected regularly. On the 28th and 32nd weeks, blood samples were collected to determine serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), uric acid (UA), creatinine (Cr), cholesterol (CH) and triglycerides (TG).


RESULTS
(1) Sign: The DOG-administered group showed reduction in the duration of vertigo and increase in appetite, body weight, locomotor activities and grip strength. (2) Blood pressure: The DOG-administered group showed significant decrease in blood pressure since the 8th week. (3) Biochemical indexes: The DOG-administered group showed notable decrease in serum ALT, AST, ALP, Cr, UA, TG level, but without significant change in TC level.


CONCLUSIONS
The long-term administration of DOG can relieve alcohol-induced hypertension, while alleviating general signs, liver and kidney injuries and abnormal blood fat biochemical indexes.
Zhejiang Chinese Medical University, Hangzhou 310053, China. lv.gy@263.net
Gui-Yuan
GY
Lv
Wenzhou Medical University, Wenzhou 325035, China.
Chao-Qun
CQ
Xia
Wenzhou Medical University, Wenzhou 325035, China.
Su-Hong
SH
Chen
Zhejiang Chinese Medical University, Hangzhou 310053, China.
Jie
J
Su
Wenzhou Medical University, Wenzhou 325035, China.
Xiao-Pang
XP
Liu
Wenzhou Medical University, Wenzhou 325035, China.
Bo
B
Li
Zhejiang Chinese Medical University, Hangzhou 310053, China.
Jian-Li
JL
Gao
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D031667:Dendrobium / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D014280:Triglycerides; D000431:Ethanol; D002784:Cholesterol