Plasma creatinine levels, estimated glomerular filtration rate and carotid intima media thickness in middle-aged women: a population based cohort study.
OBJECTIVE
The relationships between high Creatinine (Cr) levels or low estimated Glomerular Filtration Rate (eGFR) and common carotid Intima Media thickness (IMT) have been evaluated in a population-based cohort study in women, aged 30-69 (Progetto ATENA).


RESULTS
Serum Cr and eGFR were measured in 310 women, as a part of 5.062. In this group carotid ultrasound examination (B-Mode imaging) was performed and mean max IMT was calculated. Women were classified by Cr levels >1 mg/dL or eGFR < 56 ml/min. Women with Cr > 1 mg/dL (90th percentile of creatinine distribution) or eGFR less than 56 ml/min (5th percentile of eGFR distribution) had relatively more carotid plaques as compared to the rest of the cohort. Multivariate logistic analysis, after adjustment for age, demonstrated a significant association between Cr (>1 mg/dL) and IMT (≥1.2 mm): OR 4.12 (C.I 1.22-13.86), p = 0.022; or eGFR (<56 ml/min) and IMT (≥1.2 mm): OR 4.31 (C.I 1.27-14.66), p = 0.019.


CONCLUSIONS
These findings on an independent relationship between Cr and common carotid plaques in this population of middle aged women, independently of age, suggest the value of screening for early carotid disease in asymptomatic middle aged-women with mild renal insufficiency, in order to predict those at relatively higher risk for future cardiovascular events.
Department of Clinical Medicine and Surgery, University "Federico II" Medical School - Naples, Via Pansini 5, 80131 Naples, Italy. Electronic address: margenti@unina.it.
M
M
Gentile
Department of Clinical Medicine and Surgery, University "Federico II" Medical School - Naples, Via Pansini 5, 80131 Naples, Italy.
S
S
Panico
Department of Clinical Medicine and Surgery, University "Federico II" Medical School - Naples, Via Pansini 5, 80131 Naples, Italy.
A
A
Mattiello
Division of Cardiology, Moscati Hospital, Aversa, Italy.
M
M
de Michele
A. Cardarelli Hospital, Naples, Italy.
A
A
Iannuzzi
Department of Clinical Medicine and Surgery, University "Federico II" Medical School - Naples, Via Pansini 5, 80131 Naples, Italy.
F
F
Jossa
Department of Clinical Medicine and Surgery, University "Federico II" Medical School - Naples, Via Pansini 5, 80131 Naples, Italy.
G
G
Marotta
Department of Clinical Medicine and Surgery, University "Federico II" Medical School - Naples, Via Pansini 5, 80131 Naples, Italy.
P
P
Rubba
D000328:Adult; D000368:Aged; D000375:Aging; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood*; D042241:Early Diagnosis; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007668:Kidney / Q000503:physiopathology*; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000097:blood / Q000503:physiopathology*; D012307:Risk Factors; D012720:Severity of Illness Index
D015415:Biomarkers; D003404:Creatinine
Atherosclerosis; Carotid arteries; Creatinine; Ultrasound; Women; eGFR