title: The metabolic basis of pulmonary arterial hypertension.
abstract: Pulmonary arterial hypertension (PAH) is a vascular remodeling disease of the lungs resulting in heart failure and premature death. Although, until recently, it was thought that PAH pathology is restricted to pulmonary arteries, several extrapulmonary organs are also affected. The realization that these tissues share a common metabolic abnormality (i.e., suppression of mitochondrial glucose oxidation and increased glycolysis) is important for our understanding of PAH, if not a paradigm shift. Here, we discuss an emerging metabolic theory, which proposes that PAH should be viewed as a syndrome involving many organs sharing a mitochondrial abnormality and explains many PAH features and provides novel biomarkers and therapeutic targets.
authors: Department of Medicine, University of Alberta, 2C2 Walter Mackenzie Centre, 8440 112 Street Northwest, Edmonton, AB T6G 2P4, Canada.
authors: Gopinath
authors: G
authors: Sutendra
authors: Department of Medicine, University of Alberta, 2C2 Walter Mackenzie Centre, 8440 112 Street Northwest, Edmonton, AB T6G 2P4, Canada. Electronic address: em2@ualberta.ca.
authors: Evangelos D
authors: ED
authors: Michelakis
mesh_terms: D006801:Humans; D006976:Hypertension, Pulmonary / Q000145:classification / Q000453:epidemiology* / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D000860:Hypoxia / Q000503:physiopathology*; D015994:Incidence; D053858:Metabolic Networks and Pathways / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D015995:Prevalence; D013577:Syndrome; D066253:Vascular Remodeling / Q000502:physiology*