title: Correlation of β-catenin, but not PIN1 and cyclin D1, overexpression with disease-free and overall survival in patients with cancer of the parotid gland.
abstract: BACKGROUND
  Malignant tumors of the salivary glands comprise about 3% to 5% of all head and neck carcinomas. The purpose of our study was to find possible predictive and/or prognostic markers for parotid cancer.
  
  
  METHODS
  A total of 46 tissue samples of carcinomas of the parotid gland were immunohistochemically stained for ß-catenin, cyclin D1, and PIN1. The factors were analyzed regarding their prognostic value for disease-free and overall survival.
  
  
  RESULTS
  An overexpression of the cytoplasmatic ß-catenin was linked to a statistically significant worse outcome regarding disease-free (p = .0296) and overall survival (p = .0416). The 5-year overall survival was 83.9% in patients without and 0% in patients presenting with overexpression of cytoplasmatic ß-catenin. Additionally, Union Internationale Contre le Cancer (UICC) stage correlated with overall survival (p = .0306) and disease-free survival (DFS; p = .0473).
  
  
  CONCLUSIONS
  Multivariate analysis showed that overexpression of cytoplasmatic ß-catenin and the UICC stage are 2 independent prognostic markers for survival in patients with parotid cancer.
authors: Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.
authors: Claudia
authors: C
authors: Lill
authors: Sven
authors: S
authors: Schneider
authors: Rudolf
authors: R
authors: Seemann
authors: Lorenz
authors: L
authors: Kadletz
authors: Klaus
authors: K
authors: Aumayr
authors: Bahil
authors: B
authors: Ghanim
authors: Dietmar
authors: D
authors: Thurnher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D019938:Cyclin D1 / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D010307:Parotid Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D019696:Peptidylprolyl Isomerase / Q000378:metabolism*; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D051176:beta Catenin; D019938:Cyclin D1; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase
keywords: Cyclin D1; PIN1; parotid cancer; salivary gland cancer; ß-catenin