title: Concise review: forkhead pathway in the control of adult neurogenesis.
abstract: New cells are continuously generated from immature proliferating cells in the adult brain in two neurogenic niches known as the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus and the sub-ventricular zone (SVZ) of the lateral ventricles. However, the molecular mechanisms regulating their proliferation, differentiation, migration and functional integration of newborn neurons in pre-existing neural network remain largely unknown. Forkhead box (Fox) proteins belong to a large family of transcription factors implicated in a wide variety of biological processes. Recently, there has been accumulating evidence that several members of this family of proteins play important roles in adult neurogenesis. Here, we describe recent advances in our understanding of regulation provided by Fox factors in adult neurogenesis, and evaluate the potential role of Fox proteins as targets for therapeutic intervention in neurodegenerative diseases.
authors: GIGA-Neurosciences, Developmental Neurobiology Unit, University of Liège, Liège, Belgium.
authors: Emmanuelle C
authors: EC
authors: Genin
authors: Nicolas
authors: N
authors: Caron
authors: Renaud
authors: R
authors: Vandenbosch
authors: Laurent
authors: L
authors: Nguyen
authors: Brigitte
authors: B
authors: Malgrange
mesh_terms: D000328:Adult; D000818:Animals; D001483:Base Sequence; D051858:Forkhead Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D055495:Neurogenesis; D015398:Signal Transduction
chemical_list: D051858:Forkhead Transcription Factors
keywords: Neural differentiation; Neural stem cell; Progenitor cells; Proliferation; Transcription factors