title: Effect of prior oophorectomy on changes in bone mineral density and carotid artery intima-media thickness in postmenopausal women.
abstract: OBJECTIVE
  To determine the effect of prior oophorectomy in healthy postmenopausal women on the rate of loss of bone mineral density (BMD) and rate of increase in carotid artery intima-media thickness (CIMT).
  
  
  METHODS
  Secondary analysis from a randomized controlled trial.
  
  
  METHODS
  University-based research clinic.
  
  
  METHODS
  Two hundred twenty-two healthy postmenopausal women in the Greater Los Angeles area.
  
  
  METHODS
  Baseline and annual screening of BMD and assessment of CIMT every 6 months for a total of 3 years.
  
  
  METHODS
  Changes in BMD and CIMT during postmenopausal years.
  
  
  RESULTS
  Among women who were menopausal for more than 10 years, the rate of CIMT progression was statistically significantly less in women with intact ovaries compared with those in women with prior oophorectomy. In women 5-10 years postmenopause, there was a trend toward a slower loss of BMD in those who retained their ovaries, and in women more than 10 years postmenopause there was significantly less BMD loss in those who retained their ovaries.
  
  
  CONCLUSIONS
  As time from menopausal transition increases, retained ovaries are associated with a slower rate of bone loss and a slower rate of thickening of the carotid artery wall compared with rates in menopausal women with oophorectomy.
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, California. Electronic address: sjm_979@usc.edu.
authors: Sara J
authors: SJ
authors: Mucowski
authors: Atherosclerosis Research Unit, Keck School of Medicine of the University of Southern California, Los Angeles, California; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
authors: Wendy J
authors: WJ
authors: Mack
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, California.
authors: Donna
authors: D
authors: Shoupe
authors: Atherosclerosis Research Unit, Keck School of Medicine of the University of Southern California, Los Angeles, California; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
authors: Naoko
authors: N
authors: Kono
authors: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Keck School of Medicine of the University of Southern California, Los Angeles, California.
authors: Richard
authors: R
authors: Paulson
authors: Atherosclerosis Research Unit, Keck School of Medicine of the University of Southern California, Los Angeles, California; Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California.
authors: Howard N
authors: HN
authors: Hodis
mesh_terms: D015519:Bone Density / Q000502:physiology*; D059168:Carotid Intima-Media Thickness / Q000706:statistics & numerical data*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D015141:Los Angeles / Q000453:epidemiology; D008875:Middle Aged; D010052:Ovariectomy / Q000706:statistics & numerical data*; D010053:Ovary / Q000502:physiology* / Q000601:surgery*; D017698:Postmenopause / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
keywords: Menopause; bone mineral density; intima-media thickness; oophorectomy