title: Comparison of the effects of Mg-6Zn and Ti-3Al-2.5V alloys on TGF-β/TNF-α/VEGF/b-FGF in the healing of the intestinal tract in vivo.
abstract: To evaluate the different effects of Mg-6Zn alloy and Ti-3Al-2.5V alloy implants in intestinal tract healing, we compared these two different alloys with respect to their effect on a rat's intestinal tract, using serum magnesium, radiology, pathology and immunohistochemistry in vivo. It was found using the scanning electron microscope that the Mg-6Zn alloy began to degrade during the first week and that the Ti-3Al-2.5V alloy was non-degradable throughout the process. The Mg-6Zn alloy did not have an impact on serum magnesium. Superior to the Ti-3Al-2.5V alloy, the Mg-6Zn alloy enhanced the expression of transforming growth factor-β1 in healing tissue, and promoted the expression of both the vascular endothelial growth factor and the basic fibroblast growth factor, which helped angiogenesis and healing. The Mg-6Zn alloy reduced the expression of the tumor necrosis factor (TNF-α) at different stages and decreased inflammatory response, which may have been related to the zinc inhibiting TNF-α. In general, the Mg-6Zn alloy performed better than Ti-3Al-2.5V at promoting healing and reducing inflammation. The Mg-6Zn alloy may be a promising candidate for use in the pins of circular staplers for gastrointestinal reconstruction in medicine.
authors: Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai 200233, People's Republic of China. Shanghai Jiao Tong University School of Medicine, 227 South Chongqing Road, Shanghai 200025, People's Republic of China.
authors: Jun
authors: J
authors: Yan
authors: Yigang
authors: Y
authors: Chen
authors: Qingling
authors: Q
authors: Yuan
authors: Xiaohu
authors: X
authors: Wang
authors: Song
authors: S
authors: Yu
authors: Wencai
authors: W
authors: Qiu
authors: Zhigang
authors: Z
authors: Wang
authors: Kaixing
authors: K
authors: Ai
authors: Xiaonong
authors: X
authors: Zhang
authors: Shaoxiang
authors: S
authors: Zhang
authors: Changli
authors: C
authors: Zhao
authors: Qi
authors: Q
authors: Zheng
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000535:Aluminum / Q000737:chemistry; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D007249:Inflammation; D007413:Intestinal Mucosa / Q000378:metabolism*; D008274:Magnesium / Q000737:chemistry; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017207:Rats, Sprague-Dawley; D014025:Titanium / Q000737:chemistry; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014639:Vanadium / Q000737:chemistry; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*; D014945:Wound Healing; D015032:Zinc / Q000737:chemistry
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; C000592758:Mg-6Zn alloy; C508962:Tgfb1 protein, rat; C000592759:Ti-3Al-2.5V alloy; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A; C467498:vascular endothelial growth factor A, rat; D014639:Vanadium; D016222:Fibroblast Growth Factor 2; D000535:Aluminum; D014025:Titanium; D008274:Magnesium; D015032:Zinc