title: A novel example of double 6-exo-trig heterocyclization: nitrile conversion to new anticancer active (HeLa cells) primary amine ionic liquids.
abstract: Conversion of nitriles under mild conditions leads to a new class of primary amines, including room temperature ionic liquids, acting as efficient anticancer agents.
authors: Institute of Nanotechnology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz Platz 1, 76344 Eggenstein-Leopoldshafen, Germany. annie.powell@kit.edu.
authors: Denis
authors: D
authors: Prodius
authors: Hamid Saeed
authors: HS
authors: Shah
authors: Jamshed
authors: J
authors: Iqbal
authors: Anastasia
authors: A
authors: Macaeva
authors: Anatoli
authors: A
authors: Dimoglo
authors: George E
authors: GE
authors: Kostakis
authors: Nicolas
authors: N
authors: Zill
authors: Fliur
authors: F
authors: Macaev
authors: Annie K
authors: AK
authors: Powell
mesh_terms: D000588:Amines / Q000737:chemistry*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D003500:Cyclization; D006367:HeLa Cells; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry* / Q000494:pharmacology; D008968:Molecular Conformation; D009570:Nitriles / Q000737:chemistry*; D013696:Temperature; D014709:Vero Cells
chemical_list: D000588:Amines; D000970:Antineoplastic Agents; D052578:Ionic Liquids; D009570:Nitriles