title: Cell adhesion behavior in 3D hydrogel scaffolds functionalized with D- or L-aminoacids.
abstract: Alginate hydrogels functionalized with D-, or L-penicillamine (D-, L-PEN-Alg) are used as new 3D scaffolds for cell adhesion studies. The cells recognize and show different adhesion properties in the respective 3D hydrogel scaffolds. C-6-glioma and endothelial cells show higher affinity to the D-PEN than to the L-PEN functionalized 3D alginate hydrogel scaffold. The cultivated cells are harvested from the hydrogel and are reused, for example, for cell growth experiments on 2D surfaces to prove their viability as well.
authors: Institut für Biochemie, Westfälische Wilhelms-Universität Münster, Wilhelm-Klemm-Str. 2, D-48149, Münster, Germany.
authors: Kathrin
authors: K
authors: Benson
authors: Hans-Joachim
authors: HJ
authors: Galla
authors: Nermin Seda
authors: NS
authors: Kehr
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D002448:Cell Adhesion; D045744:Cell Line, Tumor; D002470:Cell Survival; D042783:Endothelial Cells / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D010396:Penicillamine / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D000464:Alginates; D000596:Amino Acids; D006603:Hexuronic Acids; D020100:Hydrogels; D020723:Glucuronic Acid; D010396:Penicillamine
keywords: cell adhesion; functionalized hydrogels; three-dimensional scaffolds