title: Wound bed preparation 2014 update: management of critical colonization with a gentian violet and methylene blue absorbent antibacterial dressing and elevated levels of matrix metalloproteases with an ovine collagen extracellular matrix dressing.
abstract: Wound bed preparation (WBP) is a paradigm for holistic patient care that includes treatment of the cause along with patient-centered concerns before optimizing the components of local wound care (debridement, infection/inflammation, moisture balance, and, when required, the edge effect). This review incorporates a methylene blue and gentian violet bound foam dressing for critical colonization and an ovine collagen extracellular matrix dressing for reduction of elevated levels of matrix metalloproteases into the WBP paradigm.
authors: R. Gary Sibbald, BSc, MD, MEd, FRCPC(Med Derm), MACP, FAAD, MAPWCA, is Professor of Public Health and Medicine, University of Toronto, Ontario, Canada; Director, International Interprofessional Wound Care Course & Masters of Science in Community Health (Prevention & Wound Care), Dalla Lana School of Public Health, University of Toronto; Past President, World Union of Wound Healing Societies; Course Coordinator, International Interprofessional Wound Care Course at New York University Medical Center, and Clinical Editor, Advances in Skin & Wound Care, Philadelphia, Pennsylvania. Liza G. Ovington, PhD, FACCWS, is Director, Medical Operations, Global Surgery Group, Ethicon Inc, Somerville, New Jersey. Elizabeth A. Ayello, PhD, RN, ACNS-BC, CWON, ETN, MAPCWA, FAAN, is Faculty, Excelsior College of Nursing, Albany, New York; Senior Advisor, The John A. Hartford Institute for Geriatric Nursing, New York; President, Ayello, Harris & Associates, New York; Course Coordinator, International Interprofessional Wound Care Course at New York University Medical Center; and Clinical Editor, Advances in Skin & Wound Care, Philadelphia, Pennsylvania. Laurie Goodman, MHScN, BA, RN, IIWCC (Toronto), is an Advanced Practice Nurse and Wound Educator, Toronto Regional Wound Healing Clinics, Ontario, Canada. James A. Elliott, MMsc, BSc, is an independent researcher, Toronto, Canada. Dr Sibbald has disclosed that his employer, the University of Toronto, is the recipient of an unconditional educational grant from Hollister Inc, research grants from Healthpoint Biotherapeutics, Systagenix, and Exiton, and was the recipient of research grants from the Government of Ontario, 3M, BSN, CIDA, Coloplast, Covidien, Gaymar, KCI, Johnson & Johnson, Registered Nurses Association of Ontario, Mölnlycke, Hollister Limited, Valeant, Shire, Galderma, Leo, Stiefel, Abbott, and Mississauga Halton Community Care Access Center; he is a board member of 3M, BSN, Coloplast, Covidien, Gaymar, KCI, Systagenix, Möln
authors: R Gary
authors: RG
authors: Sibbald
authors: Liza G
authors: LG
authors: Ovington
authors: Elizabeth A
authors: EA
authors: Ayello
authors: Laurie
authors: L
authors: Goodman
authors: James A
authors: JA
authors: Elliott
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001684:Biological Dressings; D015169:Colony Count, Microbial; D003131:Combined Modality Therapy; D003646:Debridement / Q000379:methods; D005109:Extracellular Matrix / Q000187:drug effects / Q000502:physiology; D005260:Female; D005840:Gentian Violet / Q000494:pharmacology; D006801:Humans; D008297:Male; D045726:Metalloproteases / Q000378:metabolism*; D008751:Methylene Blue / Q000494:pharmacology; D009779:Occlusive Dressings; D018802:Patient-Centered Care / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index; D012756:Sheep; D013530:Surgical Wound Infection / Q000517:prevention & control; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology*; D014947:Wounds and Injuries / Q000175:diagnosis / Q000628:therapy*
chemical_list: D000900:Anti-Bacterial Agents; D045726:Metalloproteases; D005840:Gentian Violet; D008751:Methylene Blue