title: Acute morphine treatments alleviate tremor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.
abstract: Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder associated with decreased striatal dopamine levels. Morphine has been found to elevate dopamine levels, which indicates a potential therapeutic effect in PD treatment that has not been investigated previously. To evaluate this hypothesis, an investigation of the acute effects of morphine on PD symptoms was carried out in male rhesus PD monkeys that had been induced with MPTP. All MPTP induced monkeys displayed progressive and irreversible PD motor symptoms. The behavioral response of these animals to morphine and L-Dopa were quantified with the Kurlan scale. It was found that L-Dopa alleviated bradykinesia, but did not significantly improve tremor. In contrast, acute morphine alleviated tremor significantly. These results suggested that, compared to L-Dopa, morphine has different therapeutic effects in PD therapy and may act through different biological mechanisms to alleviate PD symptoms.
authors: Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China ; University of Chinese Academy of Science, Beijing, China.
authors: Ting
authors: T
authors: Yan
authors: Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China ; University of Chinese Academy of Science, Beijing, China.
authors: Joshua Dominic
authors: JD
authors: Rizak
authors: Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China.
authors: ShangChuan
authors: S
authors: Yang
authors: Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China ; University of Chinese Academy of Science, Beijing, China.
authors: Hao
authors: H
authors: Li
authors: Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China ; University of Chinese Academy of Science, Beijing, China.
authors: Baihui
authors: B
authors: Huang
authors: Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China ; Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China ; Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China.
authors: Yuanye
authors: Y
authors: Ma
authors: Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China ; Kunming Primate Research Center, Kunming Institute of Zoology, Chinese Academy of Science, Kunming, Yunnan, China ; Yunnan Key Laboratory of Primate Biomedical Research, Kunming, Yunnan, China.
authors: Xintian
authors: X
authors: Hu
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D018476:Hypokinesia / Q000188:drug therapy / Q000503:physiopathology; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D008253:Macaca mulatta / Q000502:physiology*; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009043:Motor Activity / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy / Q000503:physiopathology; D004856:Postural Balance / Q000187:drug effects; D014202:Tremor / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D007980:Levodopa; D009020:Morphine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine