title: Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions.
abstract: There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine.
authors: Menzies School of Health Research, Casuarina, Northern Territory, Australia.
authors: Jacqueline
authors: J
authors: Deen
authors: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
authors: Mohammad
authors: M
authors: Ali
authors: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
authors: David
authors: D
authors: Sack
mesh_terms: D002771:Cholera / Q000517:prevention & control*; D022121:Cholera Vaccines / Q000627:therapeutic use*; D006293:Health Promotion / Q000379:methods*; D006801:Humans; D032541:Mass Vaccination; D015397:Program Evaluation / Q000379:methods*
chemical_list: D022121:Cholera Vaccines