title: Unusual fernane and gammacerane glycosides from the aerial parts of Spergula fallax.
abstract: The aerial parts of Spergula fallax afforded four glycosides (1-4) based on two new triterpene aglycones (1a and 2a), along with the known hopane glycoside succulentoside A. Compound 1 was identified as belonging to the fernane class, unusual migrated hopane triterpenoids, mainly isolated from ferns and only rarely from higher plants. Compounds 2-4 were assigned as gammacerane glycosides, having as aglycone a hydroxylated derivative of tetrahymanol. The structures of the isolated compounds 1-4 and their aglycones 1a and 2a obtained by acid hydrolysis were elucidated by spectroscopic data interpretation. The growth inhibitory activity of the isolated compounds and their aglycones was evaluated against the HeLa and DLD-1 cancer cell lines.
authors: Department of Botany, Faculty of Science, Aswan University , Aswan 81528, Egypt.
authors: Arafa I
authors: AI
authors: Hamed
authors: Milena
authors: M
authors: Masullo
authors: Lukasz
authors: L
authors: Pecio
authors: Dario
authors: D
authors: Gallotta
authors: Usama A
authors: UA
authors: Mahalel
authors: Sylwia
authors: S
authors: Pawelec
authors: Anna
authors: A
authors: Stochmal
authors: Sonia
authors: S
authors: Piacente
mesh_terms: D029748:Caryophyllaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004534:Egypt; D029624:Ferns / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D014315:Triterpenes; C100046:tetrahymanol; C025206:hopane