title: Regulation of an inflammatory disease: Krüppel-like factors and atherosclerosis.
abstract: This invited review summarizes work presented in the Russell Ross lecture delivered at the 2012 proceedings of the American Heart Association. We begin with a brief overview of the structural, cellular, and molecular biology of Krüppel-like factors. We then focus on discoveries during the past decade, implicating Krüppel-like factors as key determinants of vascular cell function in atherosclerotic vascular disease.
authors: From the Case Cardiovascular Research Institute, Case Western Reserve University, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Cleveland, OH (M.K.J., P.S., A.H.); and Division of Cardiovascular Medicine, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH (A.H.).
authors: Mukesh K
authors: MK
authors: Jain
authors: Panjamaporn
authors: P
authors: Sangwung
authors: Anne
authors: A
authors: Hamik
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D004247:DNA / Q000378:metabolism; D018450:Disease Progression; D042783:Endothelial Cells / Q000378:metabolism / Q000473:pathology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005487:Foam Cells / Q000378:metabolism; D005786:Gene Expression Regulation; D018056:Hemorheology; D006801:Humans; D007249:Inflammation; D051741:Kruppel-Like Transcription Factors / Q000737:chemistry / Q000502:physiology*; D016131:Lymphocyte Subsets / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008955:Models, Cardiovascular; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D051741:Kruppel-Like Transcription Factors; D009687:Nuclear Proteins; D004247:DNA
keywords: Krüppel-like transcription factors; atherosclerosis