title: The roles of the GA receptors GID1a, GID1b, and GID1c in sly1-independent GA signaling.
abstract: Gibberellin (GA) hormone signaling occurs through proteolytic and non-proteolytic mechanisms. GA binding to the GA receptor GID1 (GA-INSENSITIVE DWARF1) enables GID1 to bind negative regulators of GA responses called DELLA proteins. In proteolytic GA signaling, the SLEEPY1 (SLY1) F-box protein targets DELLA proteins in the GID1-GA-DELLA complex for destruction through the ubiquitin-proteasome pathway. Non-proteolytic GA signaling in sly1 mutants where GA cannot target DELLA proteins for destruction, requires GA and GID1 gene function. Based on comparison of gid1 multiple mutants to sly1 gid1 mutants, GID1a is the primary GA receptor stimulating stem elongation in proteolytic and non-proteolytic signaling, and stimulating fertility in proteolytic GA signaling. GID1b plays the primary role in fertility, and a secondary role in elongation during non-proteolytic GA signaling. The stronger role of GID1b in non-proteolytic GA signaling may result from the fact that GID1b has higher affinity for DELLA protein than GID1a and GID1c.
authors: Department of Crop and Soil Science; Washington State University; Pullman, WA USA.
authors: Amber L
authors: AL
authors: Hauvermale
authors: Department of Crop and Soil Science; Washington State University; Pullman, WA USA.
authors: Tohru
authors: T
authors: Ariizumi
authors: Department of Crop and Soil Science; Washington State University; Pullman, WA USA; USDA-ARS; Wheat Genetics; Quality Physiology and Disease Research Unit; Pullman, WA USA.
authors: Camille M
authors: CM
authors: Steber
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000235:genetics / Q000378:metabolism; D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D017343:Genes, Plant; D005875:Gibberellins / Q000378:metabolism* / Q000494:pharmacology; D047468:Immunoprecipitation; D059748:Proteolysis / Q000187:drug effects; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D029681:Arabidopsis Proteins; C512225:GID1a protein, Arabidopsis; C512226:GID1b protein, Arabidopsis; C512227:GID1c protein, Arabidopsis; D005875:Gibberellins; D011956:Receptors, Cell Surface; D019883:Alkyl and Aryl Transferases; C476121:SLY1 protein, Arabidopsis
keywords: F-box; GA; GA receptor; GID1; SLY1; gibberellin signaling