title: Alerting the immune system via stromal cells is central to the prevention of tumor growth.
abstract: Anticancer immunotherapies are highly desired. Conversely, unwanted inflammatory or immune responses contribute to oncogenesis, tumor progression, and cancer-related death. For non-immunogenic therapies to inhibit tumor growth, they must promote, not prevent, the activation of anticancer immune responses. Here, the central immunoregulatory role of brain-specific stromal cells and neurons as well as their ability to maintain an immunological balance and prevent the development of glioblastoma is discussed.
authors: Neuroinflammation Unit; Biotech Research & Innovation Centre (BRIC); University of Copenhagen; Copenhagen, Denmark.
authors: Shohreh
authors: S
authors: Issazadeh-Navikas
keywords: PD-L1; biomarkers; glioblastoma; inflammation and cancer; models for anticancer vaccination; models for immunostimulation; neurons