title: Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long noncoding RNA MALAT1.
abstract: MicroRNAs mainly inhibit coding genes and long non-coding RNA expression. Here, we report that hsa-miR-125b and oncogene SIRT7/ oncogenic long noncoding RNA MALAT1 were inversely expressed in bladder cancer. Hsa-miR-125b mimic downregulated, whereas hsa-miR-125b inhibitor upregulated the expression of SIRT7 and MALAT1. Binding sites were confirmed between hsa-miR-125b and SIRT7/MALAT1. Upregulation of hsa-miR-125b or downregulation of SIRT7 inhibited proliferation, motility and increased apoptosis. The effects of upregulation of hsa-miR-125b were similar to that of silencing MALAT1 in bladder cancer as we had previously described. These data suggest that hsa-miR-125b suppresses bladder cancer development via inhibiting SIRT7 and MALAT1.
authors: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, Postdoctroal Scientific Research Base, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, China.
authors: Yonghua
authors: Y
authors: Han
authors: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, Postdoctroal Scientific Research Base, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, China.
authors: Yuchen
authors: Y
authors: Liu
authors: Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen, China.
authors: Hu
authors: H
authors: Zhang
authors: Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen, China.
authors: Tiantian
authors: T
authors: Wang
authors: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, Postdoctroal Scientific Research Base, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, China.
authors: Ruiying
authors: R
authors: Diao
authors: Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen, China.
authors: Zhimao
authors: Z
authors: Jiang
authors: Guangdong Key Laboratory of Male Reproductive Medicine and Genetics, Peking University Shenzhen Hospital, Shenzhen, China. Electronic address: gytbdyy@163.com.
authors: Yaoting
authors: Y
authors: Gui
authors: Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, Postdoctroal Scientific Research Base, Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen, China. Electronic address: caizhiming2011@163.com.
authors: Zhiming
authors: Z
authors: Cai
keywords: Bladder cancer; Hsa-miR-125b; Long noncoding RNA; MALAT1; Microrna; SIRT7