title: Efficient and regioselective synthesis of novel functionalized dispiropyrrolidines and their cytotoxic activities.
abstract: An efficient and regioselective synthesis of novel functionalized dispiropyrrolizidine derivatives via a three-component [3 + 2] cycloaddition reaction of azomethine ylides is described. This protocol has the advantages of high efficiency, mild reaction conditions, a one-pot procedure, and convenient operation. Many of these compounds were evaluated for their antiproliferative properties in vitro against cancer cells and several compounds were found to have good activities.
authors: School of Pharmacy, Yancheng Teachers University , Yancheng 224051, P. R. China.
authors: Jin-Ming
authors: JM
authors: Yang
authors: Yu
authors: Y
authors: Hu
authors: Qiang
authors: Q
authors: Li
authors: Fan
authors: F
authors: Yu
authors: Jian
authors: J
authors: Cao
authors: Dong
authors: D
authors: Fang
authors: Zhi-Bin
authors: ZB
authors: Huang
authors: Da-Qing
authors: DQ
authors: Shi
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D011763:Pyrrolizidine Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011763:Pyrrolizidine Alkaloids; D013141:Spiro Compounds