title: Serum bisphenol a concentration in postmenopausal women with osteoporosis.
abstract: OBJECTIVE
  Bishphenol A (BPA) is a representative endocrine disruptor and is also known as a xenoestrogen. The objective of the present study is to investigate how many patients are exposed to BPA and to analyze the relationships between serum BPA concentration, bone mineral density (BMD) and biochemical bone markers in postmenopausal women with osteoporosis.
  
  
  METHODS
  Total 51 patients were enrolled for measuring BPA and clinical variables including BMD and bone markers. The relationship between BPA and clinical variables were analyzed by the Pearson's correlation test and the Kruskal-Wallis test. Serum BPA concentration was measured by enzyme linked immunosorbent assay (ELISA).
  
  
  RESULTS
  BPA was detected in all samples. The mean BPA concentration was 1.44 ± 0.52 ng/mL. There was no statistically significant correlation between BPA and clinical variables.
  
  
  CONCLUSIONS
  There was no statistical significance between serum BPA concentration and clinical variables related to bone metabolism. To clarify the effect of BPA on bone metabolism, further large scaled and high risk group investigation may be needed.
authors: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
authors: Dong Hyun
authors: DH
authors: Kim
authors: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
authors: Chi Hyuk
authors: CH
authors: Oh
authors: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
authors: Yoo-Chul
authors: YC
authors: Hwang
authors: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
authors: In-Kyung
authors: IK
authors: Jeong
authors: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
authors: Kyu Jeong
authors: KJ
authors: Ahn
authors: Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
authors: Ho-Yeon
authors: HY
authors: Chung
authors: Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
authors: Jae-Suk
authors: JS
authors: Chang
keywords: Bisphenol A; Bone markers; Bone mineral density; Osteoporosis