title: Gageotetrins A-C, noncytotoxic antimicrobial linear lipopeptides from a marine bacterium Bacillus subtilis.
abstract: Gageotetrins A-C (1-3), a unique class of linear lipopeptides, consisting of di- and tetrapeptides and a new fatty acid were isolated from a Marine Bacillus subtilis. The structures of 1-3 were assigned by spectroscopic data and their absolute stereochemistries were ascertained by chemical derivatization. Compounds 1-3 displayed good antimicrobial activities with MIC values of 0.01-0.06 μM. However, these compounds failed to register any cytotoxicity (GI50 > 30 μg/ml) against human cancer cell lines.
authors: Department of Marine Biotechnology, University of Science and Technology , Republic of Korea.
authors: Fakir Shahidullah
authors: FS
authors: Tareq
authors: Min Ah
authors: MA
authors: Lee
authors: Hyi-Seung
authors: HS
authors: Lee
authors: Yeon-Ju
authors: YJ
authors: Lee
authors: Jong Seok
authors: JS
authors: Lee
authors: Choudhury M
authors: CM
authors: Hasan
authors: Md Tofazzal
authors: MT
authors: Islam
authors: Hee Jae
authors: HJ
authors: Shin
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005227:Fatty Acids / Q000737:chemistry* / Q000378:metabolism; D005285:Fermentation; D006801:Humans; D055666:Lipopeptides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000890:Anti-Infective Agents; D005227:Fatty Acids; D055666:Lipopeptides; C000590588:gageotetrin A; C000590589:gageotetrin B; C000590590:gageotetrin C