title: Assessment of toxic effects of triclosan on the terrestrial snail (Achatina fulica).
abstract: Triclosan (TCS) is a broad-spectrum antimicrobial agent used in personal care products, and as a result, is widespread in the environment. Toxicity tests of TCS on aquatic organisms have been reported, but limited toxicity data on terrestrial species are available. In this study, the 28-d chronic toxicity of TCS on the biomass, shell diameter growth, and total food intake of the terrestrial snail Achatina fulica were tested. Moreover, biochemical responses, including changes in the activity of catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), and the content of malondialdehyde (MDA), were examined after 14-d and 28-d exposure. Results showed that TCS had toxic effects on the biomass, shell diameter growth, and total food intake of A. fulica with no observed effect concentration (NOEC) values of 24 mg kg(-1). As for the antioxidant enzymes, TCS caused significant oxidative stress even at the low concentration of 24 mg kg(-1). The CAT and POD activities at the high concentrations of 200 and 340 mg kg(-1), respectively, were significantly inhibited. The SOD and CAT activity in treatments below 118 mg kg(-1) and the MDA content in all treatments showed dose-effect relationships. This study demonstrated that TCS caused adverse effects on terrestrial invertebrates, and provided valuable information for the risk assessment imposed by TCS in the terrestrial environment.
authors: State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China; College of Water Sciences, Beijing Normal University, Beijing 100875, China.
authors: Xiaonan
authors: X
authors: Wang
authors: State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. Electronic address: liuzt@craes.org.cn.
authors: Zhengtao
authors: Z
authors: Liu
authors: State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
authors: Wanhua
authors: W
authors: Wang
authors: State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
authors: Zhenguang
authors: Z
authors: Yan
authors: China Offshore Environmental Services Co. Ltd., Tianjin 300452, China.
authors: Cong
authors: C
authors: Zhang
authors: State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
authors: Weili
authors: W
authors: Wang
authors: State Key Laboratory of Environmental Criteria and Risk Assessment, State Environmental Protection Key Laboratory of Ecological Effect and Risk Assessment of Chemicals, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.
authors: Lihong
authors: L
authors: Chen
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D003358:Cosmetics / Q000737:chemistry; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D010544:Peroxidases / Q000378:metabolism; D018570:Risk Assessment; D012908:Snails / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D018675:Toxicity Tests; D014260:Triclosan / Q000633:toxicity*
chemical_list: D000890:Anti-Infective Agents; D003358:Cosmetics; D014260:Triclosan; D008315:Malondialdehyde; D010544:Peroxidases; D002374:Catalase; D013482:Superoxide Dismutase
keywords: Antioxidant enzymes; Chronic toxicity test; Risk assessment; Snail (Achatina fulica); Terrestrial environment; Triclosan