title: Outcomes of congenital cataract surgery: intraoperative intracameral triamcinolone injection versus postoperative oral prednisolone.
abstract: OBJECTIVE
  To compare the outcomes of congenital cataract surgery using intraoperative intracameral triamcinolone versus postoperative oral prednisolone to modulate ocular inflammation.
  
  
  METHODS
  Department of Congenital Cataract, Altino Ventura Foundation, Recife, Brazil.
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  Children younger than 2 years were randomly divided into 2 groups. The study group received an intraoperative intracameral injection of 1.2 mg/0.03 mL of triamcinolone acetonide. The control group (29 eyes) received 1 mg/kg per day of prednisolone syrup for 15 days postoperatively, which was then tapered over the following 2 weeks. Intraocular pressure (IOP), central corneal thickness (CCT), cell deposits on the intraocular lens (IOL), posterior synechiae, visual axis obscuration, additional surgical procedures, and IOL centration were assessed 12 months postoperatively.
  
  
  RESULTS
  The mean patient age at surgery was 10.45 months±6.22 (SD) in the study group (31 eyes) and 10.0±6.15 months in the control group (29 eyes) (P=.779). In both groups, the mean IOP and CCT did not change significantly postoperatively (study group P=.922 and P=.149, respectively; control group P=.483 and P=.416, respectively). The groups had similar incidences of cell deposits (P=.517) and posterior synechiae (P=.247). No eye developed visual axis obscuration or had additional surgical procedures. All eyes had a clinically centered IOL.
  
  
  CONCLUSIONS
  One year postoperatively, the outcomes were similar with intraoperative intracameral triamcinolone injection and postoperative oral prednisolone for modulating inflammation after congenital cataract surgery.
  
  
  BACKGROUND
  No author has a financial or proprietary interest in any material or method mentioned.
authors: From the Department of Congenital Cataract (M.C. Ventura, B.V. Ventura, C.V. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Altino Ventura Foundation, and the Department of Congenital Cataract (M.C. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Pernambuco Eye Hospital, Recife; the Department of Ophthalmology (Nosé), Federal University of São Paulo, São Paulo, Brazil. Electronic address: marcelovhope@gmail.com.
authors: Marcelo C
authors: MC
authors: Ventura
authors: From the Department of Congenital Cataract (M.C. Ventura, B.V. Ventura, C.V. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Altino Ventura Foundation, and the Department of Congenital Cataract (M.C. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Pernambuco Eye Hospital, Recife; the Department of Ophthalmology (Nosé), Federal University of São Paulo, São Paulo, Brazil.
authors: Bruna V
authors: BV
authors: Ventura
authors: From the Department of Congenital Cataract (M.C. Ventura, B.V. Ventura, C.V. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Altino Ventura Foundation, and the Department of Congenital Cataract (M.C. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Pernambuco Eye Hospital, Recife; the Department of Ophthalmology (Nosé), Federal University of São Paulo, São Paulo, Brazil.
authors: Camila V
authors: CV
authors: Ventura
authors: From the Department of Congenital Cataract (M.C. Ventura, B.V. Ventura, C.V. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Altino Ventura Foundation, and the Department of Congenital Cataract (M.C. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Pernambuco Eye Hospital, Recife; the Department of Ophthalmology (Nosé), Federal University of São Paulo, São Paulo, Brazil.
authors: Liana O
authors: LO
authors: Ventura
authors: From the Department of Congenital Cataract (M.C. Ventura, B.V. Ventura, C.V. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Altino Ventura Foundation, and the Department of Congenital Cataract (M.C. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Pernambuco Eye Hospital, Recife; the Department of Ophthalmology (Nosé), Federal University of São Paulo, São Paulo, Brazil.
authors: Tiago E
authors: TE
authors: Arantes
authors: From the Department of Congenital Cataract (M.C. Ventura, B.V. Ventura, C.V. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Altino Ventura Foundation, and the Department of Congenital Cataract (M.C. Ventura), Department of Pediatric Ophthalmology and Strabismus (L.O. Ventura), and Department of Uveitis (Arantes), Pernambuco Eye Hospital, Recife; the Department of Ophthalmology (Nosé), Federal University of São Paulo, São Paulo, Brazil.
authors: Walton
authors: W
authors: Nosé
mesh_terms: D000284:Administration, Oral; D000869:Anterior Eye Segment / Q000187:drug effects; D002386:Cataract / Q000151:congenital*; D002387:Cataract Extraction; D003315:Cornea / Q000473:pathology; D063171:Corneal Pachymetry; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D056965:Injections, Intraocular; D007429:Intraocular Pressure / Q000502:physiology; D007430:Intraoperative Care / Q000379:methods; D019654:Lens Implantation, Intraocular; D008297:Male; D011182:Postoperative Care / Q000379:methods; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use*; D014606:Uveitis, Anterior / Q000517:prevention & control
chemical_list: D005938:Glucocorticoids; C009935:prednisolone acetate; D011239:Prednisolone; D014222:Triamcinolone Acetonide