title: Complement factor concentrations in patients with acute myocardial infarction: time course and ability to predict left ventricular dysfunction.
abstract: OBJECTIVE
  Inflammatory processes may contribute to myocardial ischemia/reperfusion injury after myocardial infarction (MI). We aimed to evaluate the predictive value of complement factor concentrations for the occurrence of post-MI left ventricular (LV) dysfunction.
  
  
  METHODS
  Fifty-five patients with acute MI were included. Complement factors and CRP were assessed at hospital admission (HA) and during the first 3 days. LV ejection fraction was determined by echocardiography before hospital discharge.
  
  
  RESULTS
  Total hemolytic complement (CH50) on admission and peak CRP during the first hospitalization days were higher in patients who developed LV dysfunction (LV ejection fraction ≤45%). By contrast, neither absolute concentrations of single complement factor concentrations nor changes in these concentrations over time were associated with the occurrence of LV dysfunction. CH50 at HA was independently associated with LV dysfunction.
  
  
  CONCLUSIONS
  This study generates the hypothesis that CH50 concentration at HA in patients with acute MI may identify individuals at high risk for LV dysfunction.
authors: Division of Cardiology, Kantonsspital St. Gallen, Rorschacherstrasse 95, CH-9007 St. Gallen, Switzerland.
authors: Roman
authors: R
authors: Brenner
authors: Micha T
authors: MT
authors: Maeder
authors: Lukas
authors: L
authors: Trachsel
authors: Peter
authors: P
authors: Ammann
authors: Hans
authors: H
authors: Rickli
authors: Wolfgang
authors: W
authors: Korte
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D015941:Complement Hemolytic Activity Assay; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D011237:Predictive Value of Tests; D012307:Risk Factors; D013997:Time Factors; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D003402:Creatine Kinase