title: Lighting up cells with lanthanide self-assembled helicates.
abstract: Lanthanide bioprobes and bioconjugates are ideal luminescent stains in view of their low propensity to photobleaching, sharp emission lines and long excited state lifetimes permitting time-resolved detection for enhanced sensitivity. We show here how the interplay between physical, chemical and biochemical properties allied to microfluidics engineering leads to self-assembled dinuclear lanthanide luminescent probes illuminating live cells and selectively detecting biomarkers expressed by cancerous human breast cells.
authors: Institute of Chemical Sciences and Engineering , École Polytechnique Fédérale de Lausanne , BCH 1402, 1015 Lausanne , Switzerland.
authors: Jean-Claude G
authors: JC
authors: Bünzli
keywords: bioconjugate; cell imaging; lanthanide; luminescent bioprobe; self-assembly; time-resolved luminescence microscopy