title: Single human papillomavirus 16 or 52 infection and later cytological findings in Japanese women with NILM or ASC-US.
abstract: The relationship between oncogenic human papillomavirus (HPV) infection and later cytological findings in the uterine cervix is unknown in women who were negative for intraepithelial lesion and malignancy (NILM) or atypical squamous cells of undetermined significance (ASC-US). This was investigated in this study in a Japanese population to determine the clinical utility of oncogenic (HPV) genotyping. The relative risk of progressive cytological findings 2 years after identification of oncogenic HPV infection was higher than in cases of non-oncogenic HPV infection (relative risk 3.827; 95% confidence interval (CI): 1.282-11.422), as well as in cases of negative HPV infection (relative risk 2.124; 95% CI: 1.451-3.110). Moreover, the relative risk of progression of cytological findings 2 years later in cases of HPV-16 infection was higher than in cases of HPV-52 infection (relative risk 2.094; 95% CI: 1.005-3.935). Therefore, the initial HPV-DNA genotype may be a potential predictive marker of later progression of cytological findings in the uterine cervix in cases of NILM or ASC-US.
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Shuhei
authors: S
authors: Abe
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Kiyonori
authors: K
authors: Miura
authors: Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Akira
authors: A
authors: Kinoshita
authors: Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Hiroyuki
authors: 0000000150502509
authors: H
authors: Mishima
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Shoko
authors: S
authors: Miura
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Kentaro
authors: K
authors: Yamasaki
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Yuri
authors: Y
authors: Hasegawa
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Ai
authors: A
authors: Higashijima
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Ozora
authors: O
authors: Jo
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Atsushi
authors: A
authors: Yoshida
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Masanori
authors: M
authors: Kaneuchi
authors: Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Koh-Ichiro
authors: K
authors: Yoshiura
authors: Department of Obstetrics and Gynecology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
authors: Hideaki
authors: H
authors: Masuzaki
mesh_terms: D000328:Adult; D052685:Alphapapillomavirus / Q000235:genetics*; D044466:Asian People; D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D018450:Disease Progression; D005260:Female; D005838:Genotype; D052162:Human papillomavirus 16 / Q000235:genetics*; D006801:Humans; D007564:Japan; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000150:complications*; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000209:etiology* / Q000473:pathology*