title: [Research progress in surface modification of orthopaedic implants via extracellular matrix components].
abstract: OBJECTIVE
  To review the research progress of promoting the bone formation at early stage by components of the extracellular matrix (ECM).
  
  
  METHODS
  Recent literature concerning the influence of these components on new bone formation and bone/implant contact was extensively reviewed and summarized.
  
  
  RESULTS
  Coating of titanium or hydroxyapatite implants with organic components of the ECM (such as collagen type I, chondroitin sulfate, and Arg-Gly-Asp peptide) offers great potential to improve new bone formation and enhance bone/implant contact, which in turn will shorten recovery time and improve implant stability.
  
  
  CONCLUSIONS
  The increasing knowledge about the role of the ECM for recruitment, proliferation, differentiation of cells, and regeneration of tissue will eventually deal to the creating of an artificial EGM on the implant that could allow a defined adjustment of the required properties to support the healing process.
authors: Medical Experimental and Research Center, Hebei United University, Tangshan Hebei, 063000, P.R.China.
authors: Hongkun
authors: H
authors: Zhao
authors: Medical Experimental and Research Center, Hebei United University, Tangshan Hebei, 063000, P.R.China.
authors: Qijia
authors: Q
authors: Li
authors: Medical Experimental and Research Center, Hebei United University, Tangshan Hebei, 063000, P.R.China.
authors: Qian
authors: Q
authors: Wang
authors: Department of Orthopaedics, Hebei United Univeristy.
authors: Zhiqiang
authors: Z
authors: Wang
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D002809:Chondroitin Sulfates / Q000737:chemistry* / Q000378:metabolism; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism; D024042:Collagen Type I / Q000737:chemistry* / Q000378:metabolism; D005109:Extracellular Matrix / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism; D016348:Osseointegration / Q000502:physiology; D019736:Prostheses and Implants; D013499:Surface Properties; D023822:Tissue Engineering; D014025:Titanium / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D024042:Collagen Type I; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; D002809:Chondroitin Sulfates; D014025:Titanium