title: Role of secretory phospholipase A₂ in women with metabolic syndrome.
abstract: OBJECTIVE
  Secretory phospholipase A2 (sPLA2), a member of the phospholipase A2 superfamily of enzymes that hydrolyses phospholipids, is a potentially useful plasma biomarker for atherosclerotic cardiovascular disease. Cardiovascular diseases are the leading cause of mortality in women. The purpose of this study was to investigate the correlation between cardiovascular risk factors and the sPLA2 levels in women with metabolic syndrome as compared to women without metabolic syndrome and men with metabolic syndrome.
  
  
  METHODS
  Patients (n=100) with various cardiovascular risk factors consecutively evaluated at the Rehabilitation Hospital-Cardiology Department, Cluj-Napoca, Romania were enrolled during 2011, of whom 10 were excluded. The patients were divided in three groups: group 1 (37 women with metabolic syndrome), group 2 (27 men with metabolic syndrome), and group 3 (26 women without metabolic syndrome). Body weight, smoking habits, glycaemia, hypertension, and serum lipids fractions were analysed as cardiovascular factors. Serum sPLA2 activity was measured using the chromogenic method.
  
  
  RESULTS
  There were no statistically significant correlations between sPLA2 levels and the investigated risk factors, irrespective of patient groups. However, there were significant positive correlations between sPLA2 and hsCRP in all three groups (P<0.05). In women with no metabolic syndrome an negative correlation was found between sPLA2 levels and HDL-C- r=-0.419, P=0.03. In men with metabolic syndrome there was a direct correlation between sPLA 2 levels and HOMA, r=0.43, P<0.05, 95% CI (-0.098; 1.15).
  
  
  CONCLUSIONS
  Women with metabolic syndrome did not display different sPLA2 levels as compared to men with metabolic syndrome and women without metabolic syndrome. However, women with metabolic syndrome demonstrated a low but positive correlation between sPLA2 and hsCRP levels.
authors: University of Medicine & Pharmacy, Department of Internal Medicine; Rehabilitation Hospital,Discipline of Cardiology, Department of Internal Medicine, Cluj-Napoca, Romania.
authors: D
authors: D
authors: Pop
authors: A
authors: A
authors: Sitar-Taut
authors: G
authors: G
authors: Bodisz
authors: D
authors: D
authors: Zdrenghea
authors: M
authors: M
authors: Cebanu
authors: Babes-Bolyai University, Faculty of Economics & Business Administration, Department of Economic Informatics,, Romania.
authors: L
authors: L
authors: Stanca
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000473:pathology; D008875:Middle Aged; D054497:Phospholipases A2, Secretory / Q000097:blood*; D012307:Risk Factors; D012383:Romania; D012727:Sex Characteristics
chemical_list: D002097:C-Reactive Protein; D054497:Phospholipases A2, Secretory