title: Macromolecular crowding meets tissue engineering by self-assembly: a paradigm shift in regenerative medicine.
abstract: MMC, the addition of inert polydispersed macromolecules in the culture media, effectively emulates the dense in vivo extracellular space, resulting in amplified deposition of ECM in vitro and subsequent production of cohesive, ECM-rich living substitutes.
authors: Network of Excellence for Functional Biomaterials (NFB), National University of Ireland Galway, (NUI Galway), Galway, Ireland.
authors: Abhigyan
authors: A
authors: Satyam
authors: Pramod
authors: P
authors: Kumar
authors: Xingliang
authors: X
authors: Fan
authors: Alexander
authors: A
authors: Gorelov
authors: Yury
authors: Y
authors: Rochev
authors: Lokesh
authors: L
authors: Joshi
authors: Héctor
authors: H
authors: Peinado
authors: David
authors: D
authors: Lyden
authors: Benjamin
authors: B
authors: Thomas
authors: Brian
authors: B
authors: Rodriguez
authors: Michael
authors: M
authors: Raghunath
authors: Abhay
authors: A
authors: Pandit
authors: Dimitrios
authors: D
authors: Zeugolis
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D002460:Cell Line; D003094:Collagen / Q000378:metabolism; D016264:Dextran Sulfate / Q000737:chemistry; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D046911:Macromolecular Substances / Q000737:chemistry*; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D044968:Regenerative Medicine; D023822:Tissue Engineering
chemical_list: D000180:Acrylic Resins; D046911:Macromolecular Substances; C052970:poly-N-isopropylacrylamide; D003094:Collagen; D016264:Dextran Sulfate; D020778:Matrix Metalloproteinase 2
keywords: cell-sheet tissue engineering; excluding volume effect; extracellular matrix deposition; macromolecular crowding; macromolecular polydispersity