title: Levels of serum 25-hydroxy-vitamin d in benign and malignant breast masses.
abstract: BACKGROUND
  The true association between breast cancer and vitamin D is currently under investigation. We compared serum 25-hydroxy-vitamin D levels in women with benign and malignant breast masses and controls.
  
  
  METHODS
  Levels of vitamin D were measured by electrochemiluminescense. Serum levels >35 ng/ml, 25-35 ng/ml, 12.5-25 ng/ml and <12.5 ng/ml were considered as normal, mild, moderate and severe vitamin D deficiency, respectively.
  
  
  RESULTS
  Overall, 364 women were included in the control, 172 in the benign and 136 in the malignant groups. The median serum vitamin D level was significantly lower in breast cancers than controls. Levels were also lower in malignant than benign cases and in benign cases than controls although statistically non-significant.
  
  
  CONCLUSIONS
  Multinomial logistic regression analysis showed that severe vitamin D deficiency causes a three-fold increase in the risk of breast cancer while this was not the case for moderate and mild deficiency.
authors: Department of Surgery, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran E-mail : sadafalipour@yahoo.com.
authors: Sadaf
authors: S
authors: Alipour
authors: Maryam
authors: M
authors: Hadji
authors: Ladan
authors: L
authors: Hosseini
authors: Ramesh
authors: R
authors: Omranipour
authors: Azin
authors: A
authors: Saberi
authors: Akram
authors: A
authors: Seifollahi
authors: Leila
authors: L
authors: Bayani
authors: Nooshin
authors: N
authors: Shirzad
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000097:blood*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000097:blood*; D004108:Dilatation, Pathologic / Q000097:blood; D005260:Female; D018226:Fibroadenoma / Q000097:blood*; D005348:Fibrocystic Breast Disease / Q000097:blood; D006801:Humans; D006965:Hyperplasia / Q000097:blood; D042361:Mammary Glands, Human / Q000473:pathology*; D008413:Mastitis / Q000097:blood; D010212:Papilloma / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D