title: Effect of peroxisome proliferator-activated receptor gamma agonist on heart of rabbits with acute myocardial ischemia/reperfusion injury.
abstract: OBJECTIVE
  To explore protective effect of rosiglitazone on myocardial ischemia reperfusion injury.
  
  
  METHODS
  A total of 48 male SD rats were randomly divided into control group (A), I/R group(B), high dose of rosiglitazone (C), low dose of rosiglitazone (D). Plasm concentration of creatine kinase (CK), CK-MB, hsCRP, Superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px), nitric oxide (NO) and endothelin (ET) were measured 1 h later after I/R. 24 h after I/R hearts were harvested to observe pathological and ultrastructural changes. Immunohistochemistry and western blotting was used to test CD40 expression in myocardial tissue. Area of myocardial infarction were tested, arrhythmia rate during I/R was recorded.
  
  
  RESULTS
  Plasm concentration of creatine kinase (CK), CK-MB, hsCRP, NO, MDA and ET were decreased in group C, D compared with group B. Plasm concentration of T-SOD and GSH-Px was increased significantly in group C, D compared with group B. Compared with group B, pathological and ultrastructural changes in group C, D were slightly. Myocardial infarction area and arrhythmia rate were lower in group C, D compare with group B.
  
  
  CONCLUSIONS
  Rosiglitazone can protect myocardium from I/R injury by enhancing T-SOD and GSH-Px concentration, inhibit inflammatory reaction, improve endothelial function, reduce oxidative stress and calcium overload.
authors: Emergency Department, Fifth Affiliated Hospital of Zhengzhou University, Henan 450003, China.
authors: Qian
authors: Q
authors: Hu
authors: Emergency Department, Fifth Affiliated Hospital of Zhengzhou University, Henan 450003, China.
authors: Jiong
authors: J
authors: Chen
authors: Emergency Department, Fifth Affiliated Hospital of Zhengzhou University, Henan 450003, China.
authors: Chao
authors: C
authors: Jiang
authors: Emergency Department, Fifth Affiliated Hospital of Zhengzhou University, Henan 450003, China.
authors: Heng-Fang
authors: HF
authors: Liu
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D052279:Creatine Kinase, MB Form / Q000097:blood; D016232:Endothelins / Q000097:blood; D006321:Heart / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D015428:Myocardial Reperfusion Injury / Q000097:blood* / Q000188:drug therapy*; D009206:Myocardium / Q000473:pathology; D009569:Nitric Oxide / Q000097:blood; D010088:Oxidoreductases / Q000097:blood*; D047495:PPAR gamma / Q000819:agonists*; D011817:Rabbits; D051381:Rats; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology*; D019210:Troponin I / Q000097:blood
chemical_list: D015415:Biomarkers; D016232:Endothelins; D047495:PPAR gamma; D045162:Thiazolidinediones; D019210:Troponin I; D000077154:Rosiglitazone; D009569:Nitric Oxide; D008315:Malondialdehyde; D002097:C-Reactive Protein; D010088:Oxidoreductases; D052279:Creatine Kinase, MB Form
keywords: Ischemia reperfusion injury; Rabbit; Rosiglitazone