title: OmicCircos: A Simple-to-Use R Package for the Circular Visualization of Multidimensional Omics Data.
abstract: CONCLUSIONS
  OmicCircos is an R software package used to generate high-quality circular plots for visualizing genomic variations, including mutation patterns, copy number variations (CNVs), expression patterns, and methylation patterns. Such variations can be displayed as scatterplot, line, or text-label figures. Relationships among genomic features in different chromosome positions can be represented in the forms of polygons or curves. Utilizing the statistical and graphic functions in an R/Bioconductor environment, OmicCircos performs statistical analyses and displays results using cluster, boxplot, histogram, and heatmap formats. In addition, OmicCircos offers a number of unique capabilities, including independent track drawing for easy modification and integration, zoom functions, link-polygons, and position-independent heatmaps supporting detailed visualization.
  
  
  METHODS
  OmicCircos is available through Bioconductor at http://www.bioconductor.org/packages/devel/bioc/html/OmicCircos.html. An extensive vignette in the package describes installation, data formatting, and workflow procedures. The software is open source under the Artistic-2.0 license.
authors: Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, MD 20850, USA.
authors: Ying
authors: Y
authors: Hu
authors: Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, MD 20850, USA.
authors: Chunhua
authors: C
authors: Yan
authors: Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, MD 20850, USA.
authors: Chih-Hao
authors: CH
authors: Hsu
authors: Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, MD 20850, USA.
authors: Qing-Rong
authors: QR
authors: Chen
authors: Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, MD 20850, USA.
authors: Kelvin
authors: K
authors: Niu
authors: Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, MD 20850, USA.
authors: George A
authors: GA
authors: Komatsoulis
authors: Center for Biomedical Informatics and Information Technology, National Cancer Institute, Rockville, MD 20850, USA.
authors: Daoud
authors: D
authors: Meerzaman
keywords: R package; circular plot; genomic variation