title: Gender-specific associations of the APOA1 -75G>A polymorphism with several metabolic syndrome components in Turkish adults.
abstract: BACKGROUND
  Variations in the apolipoprotein A-1 (APOA1) gene, a determinant of plasma high-density lipoprotein cholesterol (HDL-C) and apoA-I levels, may contribute to cardiovascular diseases. We evaluated the effects of a promoter polymorphism (-75G>A) in the APOA1 gene on metabolic syndrome (MetS) components in a Turkish population sample.
  
  
  METHODS
  Randomly selected 1515 Turkish adults (age 49.9±11.8 years, 785 females) were genotyped for -75G>A polymorphism using hybridization probes in Real-Time PCR LC480 device. MetS and atherogenic dyslipidemia were defined using the criteria of ATP III.
  
  
  RESULTS
  The -75AA genotype prevailed in 3.9% of men and 2.4% of women, and was independently associated with significantly higher HDL-C concentrations. Independent associations with the -75GA genotype existed only in men: higher diastolic and systolic blood pressure (BP) levels (p<0.05) were observed in male -75GA heterozygotes. Logistic regression revealed that the GA genotype confers elevated risk for atherogenic dyslipidemia (OR=1.57, 95% Cl 1.06-2.3) after adjustment for associated risk factors. Independent associations with atherogenic dyslipidemia or elevated BP did not emerge in women.
  
  
  CONCLUSIONS
  APOA1 -75G>A polymorphism is independently related to HDL-C concentrations. Independent associations of the -75GA genotype with elevated BP and atherogenic dyslipidemia were confined to men. These gender-modulated associations suggest novel gene-gender-environmental interactions.
authors: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey. Electronic address: neslihancoban@yahoo.com.
authors: Neslihan
authors: N
authors: Coban
authors: Department of Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Electronic address: alt_onat@yahoo.com.tr.
authors: Altan
authors: A
authors: Onat
authors: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey. Electronic address: filiz.geyik@gmail.com.
authors: Filiz
authors: F
authors: Guclu-Geyik
authors: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey. Electronic address: evrimbayrak@yahoo.com.
authors: Evrim
authors: E
authors: Komurcu-Bayrak
authors: Cerrahpaşa Medical Faculty, Depatrment of Public Health, Istanbul University, Istanbul, Turkey. Electronic address: alpincan@yahoo.fr.
authors: Gunay
authors: G
authors: Can
authors: Department of Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey. Electronic address: nihanerginel@yahoo.com.
authors: Nihan
authors: N
authors: Erginel-Unaltuna
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000235:genetics*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D050171:Dyslipidemias / Q000097:blood / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics* / Q000503:physiopathology; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D012727:Sex Characteristics; D014421:Turkey / Q000453:epidemiology
chemical_list: D016632:Apolipoprotein A-I; D001786:Blood Glucose; D008055:Lipids
keywords: Apolipoprotein A1; Atherogenic dyslipidemia; Blood pressure; HDL-C; Polymorphism