title: Iridium-catalyzed enantioselective allyl-alkene coupling.
abstract: The direct Ir-catalyzed cross-coupling between branched, racemic allylic alcohols and simple olefins is described. This transformation is catalyzed by an Ir-(P,olefin) complex and proceeds with high site selectivity and excellent enantioselectivity. The method allows rapid access to various 1,5-dienes or trienes and was used in the catalytic asymmetric synthesis of the γ-secretase modulator JNJ-40418677.
authors: Eidgenössische Technische Hochschule Zürich , HCI H335, 8093 Zürich, Switzerland.
authors: James Y
authors: JY
authors: Hamilton
authors: David
authors: D
authors: Sarlah
authors: Erick M
authors: EM
authors: Carreira