title: [Serum glucose concentration in subacute intoxication with chlorpyrifos - organophosphate insecticide].
abstract: BACKGROUND
  Epidemiological studies suggest that exposure to organophosphate insecticides enhances the risk of various diseases, including neurological disorders, e.g. Parkinson's or Alzheimer's disease, arteriosclerosis and diabetes mellitus. For this reason the aim of the presented study was to estimate serum concentration of glucose in subchronic intoxication with low doses of chlorpyrifos, an organophosphate insecticide.
  
  
  METHODS
  The rats received chlorpyrifos at a daily dose of 0.2, 2 or 5 mg/kg b.w./day for 14 or 28 days. For biochemical determinations of serum glucose in the rats ready-to-use kit was applied.
  
  
  RESULTS
  In subacute intoxication with chlorpyrifos the increased serum concentration of glucose was observed after 14 days of intoxication with the highest dose (5 mg/kg b.w.) and after 28 days of intoxication with all dose levels used.
  
  
  CONCLUSIONS
  The results of this study showing the increased concentration of serum glucose in subacute intoxication with low doses of chlorpyrifos, as well as the literature data suggest that exposure to organophosphate insecticides can increase the risk of diabetes mellitus. It may thus be concluded that people occupationally exposed to these compounds should be subjected to diagnostic tests for early detection of diabetes.
authors: Zakiad olbksykologii/ Department of loxicology, Uniwersytet Medyczny w Bialymstoku I Medical University in Bialystok, Bialystok, Poland. anhussa@wp.pl
authors: Anna
authors: A
authors: Lukaszewicz-Hussain
mesh_terms: D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood / Q000378:metabolism*; D002709:Chlorfenvinphos / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000009:adverse effects; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D036401:Toxicity Tests, Chronic
chemical_list: D007306:Insecticides; D006861:Hydrogen Peroxide; D043303:Aryldialkylphosphatase; D002709:Chlorfenvinphos