title: Chiral phosphorus-based 1,3-dipoles: a modular approach to enantioselective 1,3-dipolar cycloaddition and polycyclic 2-pyrroline synthesis.
abstract: The design of a new class of chiral 1,3-dipoles for enantioselective cycloaddition reactions is reported. These phosphorus-based dipoles are easily formed (from imines, acid chlorides, and chiral phosphites), rigidly chiral, and undergo intramolecular alkene cycloaddition with high enantioselectivity. Overall, this provides a straightforward and modular approach to synthesize chiral 2-pyrrolines and pyrrolidines in up to 99% ee.
authors: Department of Chemistry, McGill University , 801 Sherbrooke Street West, Montréal, QC, H3A 0B8, Canada.
authors: Marie S T
authors: MS
authors: Morin
authors: Bruce A
authors: BA
authors: Arndtsen