title: Safety of Japanese encephalitis live attenuated vaccination in post-marketing surveillance in Guangdong, China, 2005-2012.
abstract: We reviewed the adverse events following immunization of live attenuated Japanese encephalitis vaccine in Guangdong Province, China. During the period of 2005-2012, 23 million doses of live attenuated Japanese encephalitis vaccine were used and 1426 adverse events were reported (61.24 per million doses); of which, 570 (40%) were classified as allergic reactions (24.48 per million doses), 31 (2%) were neurologic events (1.33 per million doses), and 36 (2.5%) were diagnosed as serious adverse events (1.55 per million doses). This study suggests that the JEV-L has a reasonable safety profile, most adverse events are relatively mild, with relatively rare neurologic events being observed.
authors: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China.
authors: Yu
authors: Y
authors: Liu
authors: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China.
authors: Hualiang
authors: H
authors: Lin
authors: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China.
authors: Qi
authors: Q
authors: Zhu
authors: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China.
authors: Chenggang
authors: C
authors: Wu
authors: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China.
authors: Zhanjie
authors: Z
authors: Zhao
authors: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China. Electronic address: zhzgdcdc@163.com.
authors: Huizhen
authors: H
authors: Zheng
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D002648:Child; D002675:Child, Preschool; D002681:China; D004672:Encephalitis, Japanese / Q000517:prevention & control; D005260:Female; D006801:Humans; D007223:Infant; D022321:Japanese Encephalitis Vaccines / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D011358:Product Surveillance, Postmarketing; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D022321:Japanese Encephalitis Vaccines; D014613:Vaccines, Attenuated
keywords: Adverse event following immunization; Japanese encephalitis; Live attenuated vaccine; Safety