title: Bilateral choroidal excavation in best vitelliform macular dystrophy.
abstract: Focal choroidal excavation (FCE) has recently been described as one or more localized areas of choroidal excavation on spectral-domain optical coherence tomography (SD-OCT). The authors describe a case of bilateral FCE in Best vitelliform macular dystrophy (VMD). SD-OCT revealed FCE in both eyes characterized by interruption of the internal segment-outer segment junction and the presence of subretinal hyporeflective space. This is the first report describing bilateral FCE in a distinct macular disorder and specifically with VMD. Future investigations are warranted to ascertain the involvement of other macular dystrophies with atrophic evolution and the impact of FCE on the clinical course. [Ophthalmic Surg Lasers Imaging Retina. 2014;45:e8-e10.].
authors: Maurizio Battaglia
authors: MB
authors: Parodi
authors: Ilaria
authors: I
authors: Zucchiatti
authors: Francesco
authors: F
authors: Fasce
authors: Francesco
authors: F
authors: Bandello
mesh_terms: D000075002:Bestrophins; D018118:Chloride Channels / Q000235:genetics; D015862:Choroid Diseases / Q000175:diagnosis*; D004585:Electrooculography; D005136:Eye Proteins / Q000235:genetics; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000473:pathology; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis; D014792:Visual Acuity; D057826:Vitelliform Macular Dystrophy / Q000175:diagnosis* / Q000235:genetics
chemical_list: C113133:BEST1 protein, human; D000075002:Bestrophins; D018118:Chloride Channels; D005136:Eye Proteins; D012333:RNA, Messenger