title: Potential effects of Mina53 on tumor growth in human pancreatic cancer.
abstract: Myc-induced nuclear antigen (Mina53) is a protein with a molecular weight of 53 kDa expression of which is induced by c-Myc. Increased expression of Mina53 is documented in some human carcinomas. In this study, we found markedly increased Mina53 expression in pancreatic cancer tissue specimens. This expression did not correlate with clinicopathological characteristics, such as sex, age, and presence of distant metastasis. However, there was a statistically significant association with histological differentiation, TNM stage, and lymph node metastases. To study functional role of Mina53, we silenced its expression by siRNA in PANC-1 cells. These cells were arrested in the G2/M phase, and apoptosis rates were increased. In conclusion, increased expression of Mina53 may play an important role in the development of human pancreatic cancer. Mina53 can be used as a marker for pancreatic cancer and may potentially be exploited as a target for treatment of pancreatic cancer.
authors: Department of Gastroenterology, No. 1 Hospital, Yangtze University, Jingzhou, 434000, Hubei, People's Republic of China, xiaopingyanli@126.com.
authors: Xiao-ping
authors: XP
authors: Tan
authors: Wei-guo
authors: WG
authors: Dong
authors: Qing
authors: Q
authors: Zhang
authors: Zi-rong
authors: ZR
authors: Yang
authors: Xiao-fei
authors: XF
authors: Lei
authors: Ming-hua
authors: MH
authors: Ai
mesh_terms: D017209:Apoptosis / Q000235:genetics; D014408:Biomarkers, Tumor / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000235:genetics; D049308:Dioxygenases; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D056466:Histone Demethylases; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D009687:Nuclear Proteins; D034741:RNA, Small Interfering; D049308:Dioxygenases; D056466:Histone Demethylases; C466777:RIOX2 protein, human