title: Pharmacologic neuroprotective strategies in neonatal brain injury.
abstract: This article explains the mechanisms underlying choices of pharmacotherapy for hypoxic-ischemic insults of both preterm and term babies. Some preclinical data are strong enough that clinical trials are now underway. Challenges remain in deciding the best combination therapies for each age and insult.
authors: Department of Pediatrics, University of Washington, 1959 Northeast Pacific Street, Box 356320, Seattle, WA 98195, USA. Electronic address: sjuul@uw.edu.
authors: Sandra E
authors: SE
authors: Juul
authors: Neonatal Brain Disorders Laboratory, University of California, San Francisco, 675 Nelson Rising Lane, Room 494, Box 0663, San Francisco, CA 94143, USA.
authors: Donna M
authors: DM
authors: Ferriero
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use; D000493:Allopurinol / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D001708:Biopterins / Q000031:analogs & derivatives / Q000627:therapeutic use; D004921:Erythropoietin / Q000627:therapeutic use; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D005632:Fructose / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy / Q000517:prevention & control*; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000517:prevention & control*; D008550:Melatonin / Q000627:therapeutic use; D008559:Memantine / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D052250:Nitric Oxide Synthase Type III / Q000037:antagonists & inhibitors; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use; D000077236:Topiramate; D014810:Vitamin E / Q000627:therapeutic use; D014978:Xenon / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D018691:Excitatory Amino Acid Antagonists; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D013267:Stilbenes; D000077236:Topiramate; D004921:Erythropoietin; D014810:Vitamin E; D001708:Biopterins; D005632:Fructose; D014978:Xenon; D000493:Allopurinol; D052250:Nitric Oxide Synthase Type III; C003402:sapropterin; D008550:Melatonin; D001205:Ascorbic Acid; D000077185:Resveratrol; D008559:Memantine; D000111:Acetylcysteine
keywords: Brain injury; Hypoxic-ischemic encephalopathy; Preconditioning; Prematurity