title: Platelet indices in patients with de novo portal vein thrombosis and liver cirrhosis.
abstract: Platelet indices are markers of platelet reactivity used for thrombotic risk assessment in patients with cardiovascular diseases, and recently in venous thrombosis.
  
  
  OBJECTIVE
  To assess the diagnostic value of platelet indices in patients with non-malignant de novo portal vein thrombosis and liver cirrhosis.
  
  
  METHODS
  We conducted a prospective, case-control study on patients admitted to a tertiary center in the interval January, 2010 - December, 2012. Included in the study were 54 patients with portal vein thrombosis (PVT) and 54 controls. Patients with known malignancy, sepsis, thrombophilia, on anticoagulant or antiaggregant therapy, acute or chronic inflammatory diseases, severe anemia, renal failure, acute coronary syndrome, and chronic pulmonary disease were excluded from the study.
  
  
  RESULTS
  Both groups were comparable for baseline characteristics. Mean platelet volume, platelet distribution width (PDW) and plateletcrit were higher in the PVT group. In a multivariate logistic regression analysis, significant predictors of the presence of PVT were mean platelet volume (MPV), PDW, and procalcitonin (PCT).
  
  
  CONCLUSIONS
  Our data suggest that increased platelet indices contribute to the prethrombotic state in liver cirrhosis and that larger platelets may play a specific role in thrombosis despite thrombocytopenia.
authors: University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: Irina
authors: I
authors: Gîrleanu
authors: Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: Anca
authors: A
authors: Trifan
authors: Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: Camelia
authors: C
authors: Cojocariu
authors: Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: Mihaela
authors: M
authors: Dimache
authors: Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: Ana-Maria
authors: AM
authors: Sîngeap
authors: Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: Oana
authors: O
authors: Stoica
authors: Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: C
authors: C
authors: Sfarti
authors: Discipline of Gastroenterology and Hepatology, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: C
authors: C
authors: Stanciu
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006785:Hospitals, University; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011169:Portal Vein; D011446:Prospective Studies; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology*