title: The efficiency of glutamate uptake differs between neonatal and adult cortical microvascular endothelial cells.
abstract: Glutamate transporters (excitatory amino-acid transporters (EAATs)) are essential for brain homeostasis. While previous studies indicate that the vascular endothelium contributes to glutamate efflux in the adult brain, little information is available regarding glutamate uptake in the immature brain. The present study shows a differential expression pattern of EAATs between cortical microvessels in adults and newborns. In addition, adult cortical endothelial cells take up glutamate more efficiently than neonatal cells. Our findings indicate age-specific changes in extracellular glutamate regulation by brain endothelial cells, suggesting differences in the efficiency of glutamate efflux during an excitotoxic process that, in turn, may contribute to age-specific brain vulnerability.
authors: ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France.
authors: Maryline
authors: M
authors: Lecointre
authors: ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France.
authors: Michelle
authors: M
authors: Hauchecorne
authors: ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France.
authors: Armelle
authors: A
authors: Chaussivert
authors: 1] ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France [2] Department of Neonatal Pediatrics and Intensive Care, Rouen University Hospital, Rouen, France.
authors: Stéphane
authors: S
authors: Marret
authors: ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France.
authors: Philippe
authors: P
authors: Leroux
authors: ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France.
authors: Sylvie
authors: S
authors: Jegou
authors: ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France.
authors: Isabelle
authors: I
authors: Leroux-Nicollet
authors: ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France.
authors: Bruno J
authors: BJ
authors: Gonzalez
authors: ERI28 NeoVasc, Laboratory of Microvascular Endothelium and Neonate Brain Lesions, Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France.
authors: Vincent J
authors: VJ
authors: Henry
mesh_terms: D027322:Amino Acid Transport System X-AG / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D002525:Cerebellar Cortex / Q000098:blood supply* / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D018698:Glutamic Acid / Q000378:metabolism*; D051379:Mice
chemical_list: D027322:Amino Acid Transport System X-AG; D018698:Glutamic Acid