title: Association between TGM5, PPAP2B and PSMA4 polymorphisms and NSCLC in never-smoking Chinese population.
abstract: OBJECTIVE
  To explore the potential association between SNPs in transglutaminase 5 (TGM5), phosphatidic acid phosphatase type 2B (PPAP2B) and proteasome subunit, alpha type 4 (PSMA4) and non-small cell lung cancer (NSCLC) susceptibility in Chinese patients who were non-smokers.
  
  
  METHODS
  A case-controlled study was conducted among Chinese population.
  
  
  METHODS
  Two hundred NSCLC patients and 200 healthy controls who were age and sex matched were genotyped for rs504417 of TGM5, rs1261411 of PPAP2B and rs7164594 of PSMA4. Genotyping was performed using the Sequenom MassARRAY system based on the chip-based matrix-assisted laser desorption ionization time-of-flight mass spectrometry platform.
  
  
  METHODS
  The association between genotype and lung cancer risk was evaluated by computing the odds ratio (OR) and 95% confidence interval (CI) from multivariate unconditional logistic regression analyses.
  
  
  RESULTS
  There was no significant difference for the TGM5 rs504417, PPAP2B rs1261411 and PSMA4 rs716459 in allele or genotype frequencies, whether between controls and NSCLC or between controls and subgroups.
  
  
  CONCLUSIONS
  polymorphisms of TGM5, PPAP2B and PSMA4 are not major contributors to NSCLC susceptibility, this primarily be attributed to the significantly distinct genetic background of Asian populations from western populations.
authors: Department of Integration of Traditional Chinese and Western Medicine, Zhejiang cancer hospital, Hangzhou, 310022, China.
authors: M M
authors: MM
authors: Yongjun Zhang
authors: Aiqin
authors: A
authors: Zhang
authors: M M
authors: MM
authors: Hua Shi
authors: M M
authors: MM
authors: Xiangming Kong
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D010711:Phosphatidate Phosphatase / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D046988:Proteasome Endopeptidase Complex / Q000235:genetics*; D012907:Smoking; D011503:Transglutaminases / Q000235:genetics*
chemical_list: C418703:transglutaminase 5; D011503:Transglutaminases; C521833:PLPP3 protein, human; D010711:Phosphatidate Phosphatase; C000593243:PSMA4 protein, human; D046988:Proteasome Endopeptidase Complex