title: The role of KIR2DS1 in multiple sclerosis--KIR in Portuguese MS patients.
abstract: Killer Immunoglobulin-like Receptor (KIR) genes may influence both resistance and susceptibility to different autoimmune diseases, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. We investigated the influence of KIR genes on MS susceptibility in 447 MS Portuguese patients, and also whether genetic interactions between specific KIR genes and their HLA class I ligands could contribute to the pathogenesis of MS. We observed a negative association between the activating KIR2DS1 gene and MS (adjusted OR=0.450, p=0.030) independently from the presence of HLA-DRB1*15 allele. The activating KIR2DS1 receptor seems to confer protection against MS most probably through modulation of autoreactive T cells by Natural Killer cells.
authors: UMIB - Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UPorto), Porto Portugal. Electronic address: ambettencourt@icbas.up.pt.
authors: Andreia
authors: A
authors: Bettencourt
authors: UMIB - Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UPorto), Porto Portugal; Neurology Department, Centro Hospitalar do Porto - Hospital de Santo António (CHP-HSA), Porto, Portugal.
authors: Ana Martins
authors: AM
authors: Silva
authors: UMIB - Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UPorto), Porto Portugal.
authors: Cláudia
authors: C
authors: Carvalho
authors: UMIB - Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UPorto), Porto Portugal.
authors: Bárbara
authors: B
authors: Leal
authors: Neurology Department, Centro Hospitalar do Porto - Hospital de Santo António (CHP-HSA), Porto, Portugal.
authors: Ernestina
authors: E
authors: Santos
authors: UMIB - Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UPorto), Porto Portugal; Instituto Nacional de Saúde Dr. Ricardo Jorge (INSA), Porto, Portugal.
authors: Paulo P
authors: PP
authors: Costa
authors: UMIB - Instituto de Ciências Biomédicas Abel Salazar (ICBAS-UPorto), Porto Portugal.
authors: Berta M
authors: BM
authors: Silva
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D011174:Portugal / Q000453:epidemiology; D054340:Receptors, KIR / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
chemical_list: C496212:KIR2DS1 protein, human; D054340:Receptors, KIR
keywords: KIR; Multiple Sclerosis; Natural killer cells; Portugal