title: Negative autopsy and sudden cardiac death.
abstract: Forensic medicine defines the unexplained sudden death as a death with a non-conclusive diagnosis after autopsy. Molecular diagnosis is being progressively incorporated in forensics, mainly due to improvement in genetics. New genetic technologies may help to identify the genetic cause of death, despite clinical interpretation of genetic data remains the current challenge. The identification of an inheritable defect responsible for arrhythmogenic syndromes could help to adopt preventive measures in family members, many of them asymptomatic but at risk of sudden death. This multidisciplinary translational research requires a specialized team.
authors: Cardiovascular Genetic Center, University of Girona-IDIBGI, Girona, Spain.
authors: Oscar
authors: O
authors: Campuzano
authors: Catarina
authors: C
authors: Allegue
authors: Sara
authors: S
authors: Partemi
authors: Anna
authors: A
authors: Iglesias
authors: Antonio
authors: A
authors: Oliva
authors: Ramon
authors: R
authors: Brugada
mesh_terms: D001145:Arrhythmias, Cardiac / Q000235:genetics; D001344:Autopsy; D009202:Cardiomyopathies / Q000235:genetics; D053447:Channelopathies / Q000235:genetics; D004247:DNA / Q000302:isolation & purification; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D053803:Forensic Genetics; D005820:Genetic Testing; D006801:Humans; D008487:Medical History Taking; D012333:RNA, Messenger / Q000302:isolation & purification; D017422:Sequence Analysis, DNA
chemical_list: D012333:RNA, Messenger; D004247:DNA