title: Associations of Body Mass Index (Maternal BMI) and Gestational Diabetes Mellitus with Neonatal and Maternal Pregnancy Outcomes in a Multicentre European Database (Diabetes and Pregnancy Vitamin D and Lifestyle Intervention for Gestational Diabetes Mellitus Prevention).
abstract: Objective. Assess the impact of Gestational Diabetes Mellitus (GDM) and obesity on neonatal and maternal pregnancy outcomes. Methods. Cross-sectional data (3343 pregnancies) from seven European centres were included in a multilevel analysis of the association between GDM/obesity and caesarean section, macrosomia and neonatal morbidities. Results. Comparison of databases identified reporting differences between countries due to the inclusion of true population based samples or pregnancies from specialised tertiary centres, resulting in higher prevalences of GDM for some countries. The analysis showed that obesity and GDM were independent risk factors of perinatal complications. Only BMI had a dose-dependent effect on the risk of macrosomia and caesarean section. Both obesity (BMI > 30 kg/m(2)) and GDM were independent risk factors of neonatal morbidities. Conclusions. Obesity and GDM were independent risk factors of perinatal complications. The effect of the worldwide obesity and diabetes epidemic is extending to the next generation.
authors: School of Medicine, Clinical Science Institute, National University of Ireland, Galway, Ireland.
authors: Akke
authors: A
authors: Vellinga
authors: Akademia Medyczna im Karola Marcinkowskiego, 60-512 Poznan, Poland.
authors: A
authors: A
authors: Zawiejska
authors: Department of Medicine, Medical University of Vienna, 1090 Vienna, Austria.
authors: J
authors: J
authors: Harreiter
authors: School of Medicine, Clinical Science Institute, National University of Ireland, Galway, Ireland.
authors: B
authors: B
authors: Buckley
authors: Dipartimento di Endocrinologia e Malattie del Metabolismo, Università di Pisa, 56126 Pisa, Italy.
authors: G
authors: G
authors: Di Cianni
authors: Dipartimento Scienze Mediche e Chirurgiche, Università degli Studi di Padova, 35122 Padova, Italy.
authors: A
authors: A
authors: Lapolla
authors: Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain.
authors: R
authors: R
authors: Corcoy
authors: Institute of Metabolic Science, Addenbrookes Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
authors: D
authors: D
authors: Simmons
authors: Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, 08025 Barcelona, Spain.
authors: J M
authors: JM
authors: Adelantado
authors: Department of Obstetrics, Rigshospitalet, University Hospital of Copenhagen, 2100 Copenhagen, Denmark.
authors: P
authors: P
authors: Damm
authors: Department of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria.
authors: G
authors: G
authors: Desoye
authors: University Hospitals Leuven, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
authors: R
authors: R
authors: Devlieger
authors: Recherche en Sante Lawson, 9552 Bronschhofen, Switzerland.
authors: D
authors: D
authors: Hill
authors: Department of Medicine, Medical University of Vienna, 1090 Vienna, Austria.
authors: A
authors: A
authors: Kautzky-Willer
authors: Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, 00029 Helsinki, Finland.
authors: M
authors: M
authors: Klemetti
authors: Department of Obstetrics, Rigshospitalet, University Hospital of Copenhagen, 2100 Copenhagen, Denmark.
authors: E
authors: E
authors: Mathiesen
authors: BAP Health Outcomes Research, S.L, 33010 Oviedo, Spain.
authors: P
authors: P
authors: Rebollo
authors: Department of Public and Occupational Health, EMGO Institute, VU University Medical Center Amsterdam, 1007 MB Amsterdam, The Netherlands.
authors: F
authors: F
authors: Snoek
authors: Department of Obstetrics and Gynaecology, Helsinki University Central Hospital, 00029 Helsinki, Finland.
authors: M
authors: M
authors: Tikkanen
authors: University Hospitals Leuven, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
authors: D
authors: D
authors: Timmerman
authors: University Hospitals Leuven, Katholieke Universiteit Leuven, 3000 Leuven, Belgium.
authors: A
authors: A
authors: van Assche
authors: Department of Public and Occupational Health, EMGO Institute, VU University Medical Center Amsterdam, 1007 MB Amsterdam, The Netherlands.
authors: M
authors: M
authors: van Poppel
authors: Akademia Medyczna im Karola Marcinkowskiego, 60-512 Poznan, Poland.
authors: E
authors: E
authors: Wender-Oegowska
authors: School of Medicine, Clinical Science Institute, National University of Ireland, Galway, Ireland.
authors: F
authors: F
authors: Dunne