title: Novel hydrogels of chitosan and poly(vinyl alcohol)-g-glycolic acid copolymer with enhanced rheological properties.
abstract: Poly(vinyl alcohol) (PVA) has been grafted with glycolic acid (GL), a biodegradable hydroxyl acid to yield modified poly(vinyl alcohol) (PVAGL). The formation of hydrogels at pH = 6.8 and physiological temperature through blending chitosan (CS) and PVAGL at different concentrations has been investigated. FTIR, DOSY NMR and oscillatory rheology measurements have been carried out on CS/PVAGL hydrogels and the results have been compared to those obtained for CS/PVA hydrogels prepared under the same conditions. The experimental results point to an increase in the number of interactions between chitosan and PVAGL in polymer hydrogels prepared with modified PVA. The resulting materials with enhanced elastic properties and thixotropic behavior are potential candidates to be employed as injectable materials for biomedical applications.
authors: Instituto de Ciencia y Tecnología de Polímeros, CSIC, c/Juan de la Cierva 3, 28006 Madrid, Spain; University of the Basque Country (EHU-UPV), Department of Mining-Metallurgy Engineering and Materials Science, POLYMAT, School of Engineering, Alameda de Urquijo s/n, 48013 Bilbao, Spain.
authors: A
authors: A
authors: Lejardi
authors: Instituto de Ciencia y Tecnología de Polímeros, CSIC, c/Juan de la Cierva 3, 28006 Madrid, Spain. Electronic address: rhernandez@ictp.csic.es.
authors: R
authors: R
authors: Hernández
authors: Instituto de Ciencia y Tecnología de Polímeros, CSIC, c/Juan de la Cierva 3, 28006 Madrid, Spain.
authors: M
authors: M
authors: Criado
authors: NMR Facility, SGIKER, University of the Basque Country UPV/EHU, Joxe Mari Korta Zentroa, Tolosa Hiribidea 72, 20018 Donostia-San Sebastián, Spain.
authors: Jose I
authors: JI
authors: Santos
authors: Department of Polymer Science and Technology, Institute of Polymer Materials, University of the Basque Country (EHU-UPV), M. de Lardizabal, 3, 20018 Donostia-San Sebastián, Spain.
authors: A
authors: A
authors: Etxeberria
authors: University of the Basque Country (EHU-UPV), Department of Mining-Metallurgy Engineering and Materials Science, POLYMAT, School of Engineering, Alameda de Urquijo s/n, 48013 Bilbao, Spain.
authors: J R
authors: JR
authors: Sarasua
authors: Instituto de Ciencia y Tecnología de Polímeros, CSIC, c/Juan de la Cierva 3, 28006 Madrid, Spain; Department of Polymer Science and Technology, Institute of Polymer Materials, University of the Basque Country (EHU-UPV), M. de Lardizabal, 3, 20018 Donostia-San Sebastián, Spain.
authors: C
authors: C
authors: Mijangos
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D006016:Glycolates / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D012212:Rheology
chemical_list: D006016:Glycolates; D020100:Hydrogels; C031149:glycolic acid; D011142:Polyvinyl Alcohol; D048271:Chitosan
keywords: Chitosan; Glycolic acid; Hydrogels; Interactions; PVA grafting; Rheology