title: Towards the diastereoselective synthesis of derivative of 11'-epi-brevipolide H.
abstract: An efficient diastereoselective synthesis of brevipolide H derivative is described. The approach features the use of (i) catalytic asymmetric transfer hydrogenation, (ii) hydroxyl-directed cyclopropanation, and (iii) substrate-controlled catalytic epoxidation and ring-closing metathesis. Remarkably, in this convergent synthesis process, stereogenic centers were installed through catalytic reactions with high stereocontrol, which greatly facilitates the synthesis of stereo-divergent derivatives.
authors: Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad-500 607, India. gkswamy_iict@yahoo.co.in.
authors: Gullapalli
authors: G
authors: Kumaraswamy
authors: Neerasa
authors: N
authors: Jayaprakash
authors: Dasa
authors: D
authors: Rambabu
authors: Anirban
authors: A
authors: Ganguly
authors: Aniban
authors: A
authors: Ganguly
authors: Rajkumar
authors: R
authors: Banerjee
mesh_terms: D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D032411:Lippia / Q000737:chemistry; D061986:MCF-7 Cells; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011753:Pyrones; D013237:Stereoisomerism
chemical_list: D003521:Cyclopropanes; D011753:Pyrones; C000592380:brevipolide H