title: Pulmonary Mycobacterium bovis BCG vaccination confers dose-dependent superior protection compared to that of subcutaneous vaccination.
abstract: Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous vaccination.
authors: Grupo de Genética de Micobacterias, Departmento de Microbiología, Medicina Preventiva y Salud Pública, Faculty of Medicine, Universidad de Zaragoza, Zaragoza, Spain.
authors: Nacho
authors: N
authors: Aguilo
authors: Ana Maria
authors: AM
authors: Toledo
authors: Eva Maria
authors: EM
authors: Lopez-Roman
authors: Esther
authors: E
authors: Perez-Herran
authors: Eamonn
authors: E
authors: Gormley
authors: Joaquin
authors: J
authors: Rullas-Trincado
authors: Iñigo
authors: I
authors: Angulo-Barturen
authors: Carlos
authors: C
authors: Martin
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D007279:Injections, Subcutaneous; D008168:Lung / Q000276:immunology / Q000382:microbiology; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods*
chemical_list: D001500:BCG Vaccine