title: [Selenium and glutathione peroxidase in patients with preeclampsia].
abstract: The incidence of preeclampsia is between 3% and 10% ofpregnancies. Pregnancy is associated with increased oxidative stress.
  
  
  OBJECTIVE
  To investigate the level of Selenium and Glutathion peroxidise in women with normal pregnancy, and women with Preeclampsia.
  
  
  METHODS
  A total of 105 women (35 healthy nonpregnant, 35 healthy pregnant women and 35 pregnant women with PE) provided their blood at 28 to 37 weeks of gestation and were prospectively followed through delivery. These samples were used to assess a erythrocyte glutathione peroxidase and Selenium.
  
  
  RESULTS
  Compared with women with uncomplicated pregnancies, and with nonpregnant women, significantly low glutathione peroxidase and Selenium levels were noted in women who developed preeclampsia. (P <0.001) CONCLUSIONS: The reduced selenium in the maternal circulation in preeclampsia was associated with lower maternal plasma GPx activity in the preeclamptic women, supporting the hypothesis that insufficient antioxidant defense may be a contributing i factor to the pathophysiological mechanisms associated with oxidative stress and preeclampsia.
authors: M
authors: M
authors: Malinova
authors: V
authors: V
authors: Paskaleva
mesh_terms: D000328:Adult; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood* / Q000201:enzymology* / Q000473:pathology; D011247:Pregnancy; D012643:Selenium / Q000097:blood*; D055815:Young Adult
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium