title: Effects of honokiol on sepsis-induced acute kidney injury in an experimental model of sepsis in rats.
abstract: Acute kidney injury (AKI) is a severe complication of sepsis, which largely contributes to the high mortality rate of sepsis. Honokiol, a natural product isolated from Magnolia officinalis (Houpo), has been shown to exhibit anti-inflammatory and antioxidant properties. Here, we investigated the effects of honokiol on sepsis-associated AKI in rats subjected to cecal ligation and puncture (CLP). We found that the administration of honokiol improved the survival of septic rats. Periodic acid-Schiff stain revealed that the morphological changes of kidney tissues in CLP rats were restored after honokiol treatment. Furthermore, honokiol reduced CLP-induced oxidative stress and inflammatory cytokine production. The levels of nitric oxide (NO) and inducible NO synthetase (iNOS) were attenuated by honokiol in septic rats. Finally, honokiol inhibited CLP-induced activation of NF-κB signaling in CLP rats. Our findings suggest that honokiol might be used as a potential therapeutic agent for complications of sepsis, especially for sepsis-induced AKI.
authors: Graduate School of Dalian Medical University, Dalian, 116044, People's Republic of China.
authors: Nan
authors: N
authors: Li
authors: Hua
authors: H
authors: Xie
authors: Longkai
authors: L
authors: Li
authors: Jing
authors: J
authors: Wang
authors: Ming
authors: M
authors: Fang
authors: Ning
authors: N
authors: Yang
authors: Hongli
authors: H
authors: Lin
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology*; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D007249:Inflammation; D007668:Kidney / Q000473:pathology; D017705:Lignans / Q000494:pharmacology*; D008297:Male; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000150:complications* / Q000188:drug therapy*; D015398:Signal Transduction; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016207:Cytokines; D017705:Lignans; D016328:NF-kappa B; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols; C496318:Nos2 protein, rat