title: Impact of STAT1 and CD8+T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors.
abstract: We have recently demonstrated that CD8+T cells provide a critical contribution to the antineoplastic activity of 2 chemotherapeutic agents, i.e., doxorubicin and lapatinib, in a model of spontaneous mammary carcinogenesis. The activation of CD8+T cells and their recruitment to neoplastic lesions turned out to rely on signal transduction and activator of transcription 1 (STAT1). Accordingly, STAT1-deficient tumor-bearing mice exhibited an impaired response to chemotherapy.
authors: Division of Medical Biochemistry; Biocenter; Innsburck Medical University; Innsbruck, Austria.
authors: Piotr
authors: P
authors: Tymoszuk
authors: Division of Medical Biochemistry; Biocenter; Innsburck Medical University; Innsbruck, Austria.
authors: Wolfgang
authors: W
authors: Doppler
keywords: CD8+ T cells; CXCR3 ligands; STAT1; antitumor immunity; doxorubicin; lapatinib; mammary cancer