title: Patient-specific biomechanical modeling of ventricular enlargement in hydrocephalus from longitudinal magnetic resonance imaging.
abstract: Ogden type of hyperelastic constitutive law has recently emerged in modeling ventricular enlargement in hydrocephalic brain with finite element method, but this material property for brain tissue has not been investigated in a patient-specific setting in hydrocephalus. Consequently, the accuracy of the simulated ventricular enlargement using this hyperelastic tissue property remains unknown. In this study, we evaluated this brain material model in four patients with communicating hydrocephalus under a small trans-mantle pressure difference (TPMD) between brain ventricle and subarachnoid space (< 1 mmHg). Based upon changes in ventricular geometries obtained with sequential MRI, we found that this hyper-elastic model has a great flexibility and accuracy in modeling ventricular enlargement (with errors less than 1 mm). Our study supports the utility of this hyperelastic constitutive law for future hydrocephalus modeling and suggests that the observed ventricular enlargement in these patients may be caused by a slight increase in TMPD.
authors: Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, 27599, USA. yasheng_chen@med.unc.edu
authors: Yasheng
authors: Y
authors: Chen
authors: Dept. of Neurology, University of North Carolina at Chapel Hill, NC, 27599, USA.
authors: Zheng
authors: Z
authors: Fan
authors: Dept. of Pediatrics, University of North Carolina at Chapel Hill, NC, 27599, USA.
authors: Songbai
authors: S
authors: Ji
authors: Dept. of Genetics, University of North Carolina at Chapel Hill, NC, 27599, USA.
authors: Joseph
authors: J
authors: Muenzer
authors: Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, 27599, USA.
authors: Hongyu
authors: H
authors: An
authors: Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, NC, 27599, USA.
authors: Weili
authors: W
authors: Lin
mesh_terms: D000465:Algorithms; D002552:Cerebral Ventricles / Q000473:pathology* / Q000503:physiopathology*; D003198:Computer Simulation; D055119:Elastic Modulus; D006849:Hydrocephalus / Q000473:pathology* / Q000503:physiopathology*; D006984:Hypertrophy / Q000473:pathology / Q000503:physiopathology; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007427:Intracranial Pressure; D008137:Longitudinal Studies; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008954:Models, Biological; D009929:Organ Size; D018802:Patient-Centered Care / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique