title: Galectin-3 in cancer.
abstract: Galectin-3 (Gal-3) plays important roles in cell proliferation, adhesion, differentiation, angiogenesis and apoptosis in normal and pathologic tissues. Accumulated evidences indicate that Gal-3 is closely involved in tumor cell transformation, migration, invasion and metastasis. In this review, the associations of the expression and localization of Gal-3 as well as its potential action mechanism in tumorigenesis in a variety of cancers were summarized and concluded. Gal-3 is gaining its attraction as a potential new biomarker for the diagnosis, treatment and prognosis of certain tumors.
authors: The Key Laboratory of Tumor Metastasis in Liaoning Province, Department of Pathology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China.
authors: Lin
authors: L
authors: Song
authors: The Key Laboratory of Tumor Metastasis in Liaoning Province, Department of Pathology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China. Electronic address: jwtang_53@sina.cn.
authors: Jian-wu
authors: JW
authors: Tang
authors: Department of Biochemistry and Molecular Biology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China.
authors: Lawrence
authors: L
authors: Owusu
authors: Department of Biochemistry and Molecular Biology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China.
authors: Ming-Zhong
authors: MZ
authors: Sun
authors: The Key Laboratory of Tumor Metastasis in Liaoning Province, Department of Pathology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China.
authors: Jun
authors: J
authors: Wu
authors: The Key Laboratory of Tumor Metastasis in Liaoning Province, Department of Pathology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China.
authors: Jun
authors: J
authors: Zhang
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D037502:Galectin 3 / Q000032:analysis / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D037502:Galectin 3
keywords: Cancer; Expression; Galectin-3 (Gal-3); Location; Mechanism