title: Electroporation-mediated intradermal delivery of DNA vaccines in nonhuman primates.
abstract: Strategies to improve vaccine efficacy are still required. The immunogenicity of DNA vaccines is strongly improved by electroporation (EP). The skin is populated with a wide variety of immune cells, making it an attractive tissue for vaccine delivery. Here we describe a method for the EP-mediated intradermal delivery of DNA vaccines in nonhuman primates, as a model for preclinical development of human vaccines, using noninvasive needleless electrodes.
authors: Division of Immuno-Virology, CEA, Institute for Emerging Diseases and Innovative Therapies (iMETI), Fontenay-aux-Roses, France.
authors: Lucille
authors: L
authors: Adam
authors: Roger
authors: R
authors: Le Grand
authors: Frédéric
authors: F
authors: Martinon
mesh_terms: D000818:Animals; D018274:Electroporation / Q000379:methods*; D007271:Injections, Intradermal; D008251:Macaca; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000378:metabolism*
chemical_list: D019444:Vaccines, DNA