title: Calibrating optical tweezers with Bayesian inference.
abstract: We present a new method for calibrating an optical-tweezer setup that does not depend on input parameters and is less affected by systematic errors like drift of the setup. It is based on an inference approach that uses Bayesian probability to infer the diffusion coefficient and the potential felt by a bead trapped in an optical or magnetic trap. It exploits a much larger amount of the information stored in the recorded bead trajectory than standard calibration approaches. We demonstrate that this method outperforms the equipartition method and the power-spectrum method in input information required (bead radius and trajectory length) and in output accuracy.
authors: Maximilian U
authors: MU
authors: Richly
authors: Silvan
authors: S
authors: Türkcan
authors: Antoine
authors: A
authors: Le Gall
authors: Nicolas
authors: N
authors: Fiszman
authors: Jean-Baptiste
authors: JB
authors: Masson
authors: Nathalie
authors: N
authors: Westbrook
authors: Karen
authors: K
authors: Perronet
authors: Antigoni
authors: A
authors: Alexandrou
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001499:Bayes Theorem; D002138:Calibration; D003627:Data Interpretation, Statistical; D052898:Optical Tweezers