title: Copper-promoted reductive homocoupling of quasi-aromatic iron(II) clathrochelates: boosting the inhibitory activity in a transcription assay.
abstract: A copper-promoted reductive homocoupling reaction, for the first time used for a metal complex, allowed obtaining a new kind of complexes with the encapsulated metal ions, C-C conjugated bis-clathrochelates. These compounds demonstrate extremely high transcription inhibition activity in the T7 RNA polymerase system with values of IC50 reaching as low as the submicromolar range, which places them among the most potent metal-based transcription inhibitors.
authors: Nesmeyanov Institute of Organoelement Compounds RAS, Moscow, Russia. voloshin@ineos.ac.ru.
authors: O A
authors: OA
authors: Varzatskii
authors: V V
authors: VV
authors: Novikov
authors: S V
authors: SV
authors: Shulga
authors: A S
authors: AS
authors: Belov
authors: A V
authors: AV
authors: Vologzhanina
authors: V V
authors: VV
authors: Negrutska
authors: I Y
authors: IY
authors: Dubey
authors: Yu N
authors: YN
authors: Bubnov
authors: Ya Z
authors: YZ
authors: Voloshin
mesh_terms: D002614:Chelating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry*; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors* / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship; D014158:Transcription, Genetic / Q000187:drug effects* / Q000235:genetics; D014764:Viral Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics
chemical_list: D002614:Chelating Agents; D004791:Enzyme Inhibitors; D005296:Ferrous Compounds; D009942:Organometallic Compounds; D014764:Viral Proteins; D003300:Copper; C062210:bacteriophage T7 RNA polymerase; D012321:DNA-Directed RNA Polymerases