title: Physicochemical characteristics of Fe3O4 magnetic nanocomposites based on Poly(N-isopropylacrylamide) for anti-cancer drug delivery.
abstract: BACKGROUND
  Hydrogels are a class of polymers that can absorb water or biological fluids and swell to several times their dry volume, dependent on changes in the external environment. In recent years, hydrogels and hydrogel nanocomposites have found a variety of biomedical applications, including drug delivery and cancer treatment. The incorporation of nanoparticulates into a hydrogel matrix can result in unique material characteristics such as enhanced mechanical properties, swelling response, and capability of remote controlled actuation.
  
  
  METHODS
  In this work, synthesis of hydrogel nanocomposites containing magnetic nanoparticles are studied. At first, magnetic nanoparticles (Fe3O4) with an average size 10 nm were prepared. At second approach, thermo and pH-sensitive poly (N-isopropylacrylamide -co-methacrylic acid-co-vinyl pyrrolidone) (NIPAAm-MAA- VP) were prepared. Swelling behavior of co-polymer was studied in buffer solutions with different pH values (pH=5.8, pH=7.4) at 37 °C. Magnetic iron oxide nanoparticles (Fe3O4) and doxorubicin were incorporated into copolymer and drug loading was studied. The release of drug, carried out at different pH and temperatures. Finally, chemical composition, magnetic properties and morphology of doxorubicin-loaded magnetic hydrogel nanocomposites were analyzed by FT- IR, vibrating sample magnetometry (VSM), scanning electron microscopy (SEM).
  
  
  RESULTS
  The results indicated that drug loading efficiency was increased by increasing the drug ratio to polymer. Doxorubicin was released more at 40 °C and in acidic pH compared to that 37 °C and basic pH.
  
  
  CONCLUSIONS
  This study suggested that the poly (NIPAAm-MAA-VP) magnetic hydrogel nanocomposite could be an effective carrier for targeting drug delivery systems of anti-cancer drugs due to its temperature sensitive properties.
authors: Department of Medical Nanotechnology, Faculty of Advanced Medical Science, Tabriz University of Medical Sciences, Tabriz, Iran E-mail : akbarzadehab@tbzmed.ac.ir, davaran@tbzmed.ac.ir.
authors: Soodabeh
authors: S
authors: Davaran
authors: Samira
authors: S
authors: Alimirzalu
authors: Kazem
authors: K
authors: Nejati-Koshki
authors: Hamid Tayef
authors: HT
authors: Nasrabadi
authors: Abolfazl
authors: A
authors: Akbarzadeh
authors: Amir Ahmad
authors: AA
authors: Khandaghi
authors: Mojtaba
authors: M
authors: Abbasian
authors: Somayeh
authors: S
authors: Alimohammadi
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D055598:Chemical Phenomena; D004317:Doxorubicin / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D060328:Magnetic Phenomena; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D044367:Phase Transition; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D000180:Acrylic Resins; D000970:Antineoplastic Agents; D004337:Drug Carriers; D020100:Hydrogels; D058185:Magnetite Nanoparticles; C052970:poly-N-isopropylacrylamide; D004317:Doxorubicin