title: Co(acac)2/O2-mediated oxidative isocyanide insertion with 2-aryl anilines: efficient synthesis of 6-amino phenanthridine derivatives.
abstract: A novel and efficient protocol for the creation of 6-amino phenanthridine derivatives by Co(acac)2-catalyzed isocyanide insertion with 2-aryl anilines under an O2 atmosphere via homolytic aromatic substitution (HAS) type C-H functionalization has been developed. This reaction not only proceeds smoothly utilizing O2 as the oxidant but also provides a new approach to construct phenanthridine derivatives utilizing readily available 2-aryl anilines with isocyanides instead of 2-isocyanobiaryls with different radical precursors.
authors: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University , Suzhou 215123, China.
authors: Tong-Hao
authors: TH
authors: Zhu
authors: Shun-Yi
authors: SY
authors: Wang
authors: Yang-Qing
authors: YQ
authors: Tao
authors: Tian-Qi
authors: TQ
authors: Wei
authors: Shun-Jun
authors: SJ
authors: Ji
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000814:Aniline Compounds; D003486:Cyanides; D010617:Phenanthridines