title: MAM-2201 (analytically confirmed) intoxication after "Synthacaine" consumption.
abstract: Excitatory behavior, xerostomia, chest pain, severe dyspnea, tachycardia (150 beats/min), and mild hypertension (160/80 mm Hg) without ECG abnormalities were observed in a 20-year-old subject 6 hours after nasal insufflation (snorting) of a "legally" obtained white powdered substance sold as Synthacaine. A serum sample was found to contain MAM-2201 (11 ng/mL), a synthetic cannabinoid receptor agonist, and benzocaine. The patient's symptoms improved after administration of diazepam and intravenous fluids. Synthacaine was sold as legal cocaine, suggesting the user can expect an effect like that of cocaine. The pharmacologic receptor profile and chemical structure of MAM-2201 is similar to the synthetic cannabinoid receptor agonists AM-2201 and JWH-122 (2 potent synthetic cannabinoid receptor agonists with high affinity to cannabinoid receptors).
authors: Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, IRCCS Maugeri Foundation, Pavia, Italy. Electronic address: davide.lonati@fsm.it.
authors: Davide
authors: D
authors: Lonati
authors: Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, IRCCS Maugeri Foundation, Pavia, Italy.
authors: Eleonora
authors: E
authors: Buscaglia
authors: Laboratory of Analytical Toxicology, Clinical Chemistry Service, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
authors: Pietro
authors: P
authors: Papa
authors: Laboratory of Analytical Toxicology, Clinical Chemistry Service, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
authors: Antonella
authors: A
authors: Valli
authors: Laboratory of Clinical Toxicology, Institute of Pavia, IRCCS Maugeri Foundation, Pavia, Italy.
authors: Teresa
authors: T
authors: Coccini
authors: Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, IRCCS Maugeri Foundation, Pavia, Italy.
authors: Andrea
authors: A
authors: Giampreti
authors: Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, IRCCS Maugeri Foundation, Pavia, Italy.
authors: Valeria Margherita
authors: VM
authors: Petrolini
authors: Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, IRCCS Maugeri Foundation, Pavia, Italy.
authors: Sarah
authors: S
authors: Vecchio
authors: Department for Antidrug Policies, Presidency of the Council of Ministers, Rome, Italy.
authors: Giovanni
authors: G
authors: Serpelloni
authors: Poison Control Centre and National Toxicology Information Centre, Toxicology Unit, IRCCS Maugeri Foundation, Pavia, Italy.
authors: Carlo Alessandro
authors: CA
authors: Locatelli
mesh_terms: D001566:Benzocaine / Q000009:adverse effects / Q000032:analysis; D063386:Cannabinoid Receptor Agonists / Q000009:adverse effects* / Q000032:analysis; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects / Q000737:chemistry*; D007211:Indoles / Q000009:adverse effects* / Q000032:analysis; D008297:Male; D009281:Naphthalenes / Q000009:adverse effects* / Q000032:analysis; D055815:Young Adult
chemical_list: C000594853:1-(5-fluoropentyl)-3-(4-methyl-1-naphthoyl)indole; D063386:Cannabinoid Receptor Agonists; D013287:Illicit Drugs; D007211:Indoles; D009281:Naphthalenes; D001566:Benzocaine