title: [Diabetic chorea].
abstract: Diabetic chorea is characterized by acute hemichorea, as observed on striatal T1 magnetic resonance imaging (MRI), and is associated with hyperglycemia. Acute involuntary movements begin with the onset of hyperglycemia. This condition produces characteristic MR images, which are the key diagnostic feature. Contralateral T1 MRI hyperdensities have been observed in virtually all cases and are used as a diagnostic measure. In some cases, smaller, less dense lesions are seen on the ipsilateral side. The putamen is always involved, whereas the caudate and globus pallidus are involved occasionally. This lesion is usually well delineated and does not follow vascular distribution. Diffusion-weighted imaging (DWI) and the apparent diffusion coefficient show restricted diffusion on the corresponding side of the putamen. Increased susceptibility (hypodensity) is observed using susceptibility-weighted imaging (SWI). Perhaps the most parsimonious explanation for the imaging results is that they represent gemistocytes. Pathological studies have confirmed the presence of gemistocytes, and these findings are consistent with T1, T2, DWI, and SWI MRI sequence findings. The zinic-laden metallothionein protein in the gemistocytes is the primary reason for the diagnostic imaging findings. The first avenue of treatment is to address the underlying hyperglycemia. As the hyperglycemia decreases, the chorea improves over the subsequent days or weeks, in most cases. If the chorea is uncomfortable, disabling, or persistent, symptomatic therapy (e.g., administration of haloperidol, a dopamine antagonist) should be initiated.
authors: Department of Neurology, Brain Attack Center Ohta Memorial Hospital.
authors: Kazuhiro
authors: K
authors: Takamatsu
mesh_terms: D001921:Brain / Q000473:pathology*; D002819:Chorea / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D048909:Diabetes Complications / Q000628:therapy*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000473:pathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D011379:Prognosis