title: A cooperative water effect in proazaphosphatrane-catalysed heterocycle synthesis.
abstract: The synthesis of oxazolines and imidazolines was achieved by activation of isocyanides with water. Mechanistic studies show that the organosuperbase proazaphosphatrane is tolerant of water within the reaction medium, with a beneficial and cooperative effect being observed.
authors: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. shu_kobayashi@chem.s.u-tokyo.ac.jp.
authors: Mark A
authors: MA
authors: Honey
authors: Yasuhiro
authors: Y
authors: Yamashita
authors: Shū
authors: S
authors: Kobayashi
mesh_terms: D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D048288:Imidazolines / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010080:Oxazoles / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D003486:Cyanides; D048288:Imidazolines; D009943:Organophosphorus Compounds; D010080:Oxazoles; D014867:Water; C449943:P(CH(3)NCH(2)CH(2))(3)N