title: A genetic variant in MiR-146a modifies digestive system cancer risk: a meta-analysis.
abstract: MicroRNAs (miRNAs) negatively regulate gene expression and act as tumor suppressors or oncogenes in oncogenesis. The association between a single nucleotide polymorphism (SNP) in miR-146a rs2910164 and susceptibility to digestive system cancers was inconsistent in previous studies. In this study, we conducted a literature search of PubMed to identify all relevant studies published before August 31, 2013. A total of 21 independent case-control studies were included in this updated meta-analysis with 9,558 cases and 10,614 controls. We found that the miR-146a rs2910164 polymorphism was significantly associated with decreased risk of digestive system cancers in an allele model (OR=0.90, 95%CI 0.87-0.94), homozygote model (OR=0.84, 95%CI 0.77-0.91), dominant model (OR=0.90, 95%CI 0.84-0.96), and recessive model (OR=0.85, 95%CI 0.79-0.91), while in a heterozygous model (OR = 0.99, 95% CI 0.89-1.11) the association showed marginal significance. Subgroup analysis by cancer site revealed decreased risk in colorectal cancer above allele model (OR=0.90, 95%CI 0.83- 0.97) and homozygote model (OR=0.85, 95%CI 0.72-1.00). Similarly, decreased cancer risk was observed when compared with allele model (OR=0.87, 95%CI 0.81-0.93) and recessive model (OR=0.81, 95%CI 0.72-0.90) in gastric cancer. When stratified by ethnicity, genotyping methods and quality score, decreased cancer risks were also observed. This current meta-analysis indicated that miR-146a rs2910164 polymorphism may decrease the susceptibility to digestive system cancers, especially in Asian populations.
authors: Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, China E-mail : ck@zju.edu.cn.
authors: Ying-Jun
authors: YJ
authors: Li
authors: Zhen-Yu
authors: ZY
authors: Zhang
authors: Ying-Ying
authors: YY
authors: Mao
authors: Ming-Juan
authors: MJ
authors: Jin
authors: Fang-Yuan
authors: FY
authors: Jing
authors: Zhen-Hua
authors: ZH
authors: Ye
authors: Kun
authors: K
authors: Chen
mesh_terms: D000483:Alleles; D015179:Colorectal Neoplasms / Q000208:ethnology / Q000235:genetics; D004067:Digestive System Neoplasms / Q000208:ethnology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs