title: Automatic volumetry of the cerebrospinal fluid space in idiopathic normal pressure hydrocephalus.
abstract: OBJECTIVE
  To measure the cerebrospinal fluid (CSF) space volume in idiopathic normal pressure hydrocephalus (INPH), we developed a software that allows us to automatically measure the regional CSF space and compared the volumes of the ventricle systems (VS), Sylvian fissures (SF) and sulci at high convexity and midline (SHM) among INPH patients, Alzheimer's disease (AD) patients and healthy volunteers (HVs).
  
  
  METHODS
  Fifteen INPH patients, 15 AD patients and 15 HVs were retrospectively selected for this study. 3D-T1 MR images were obtained. We improved upon an automatic gray matter volume system to measure CSF spaces, adopting new regions for the template of INPH-characteristic CSF spaces and measured them. The VS, SF and SHM volumes were calculated relative to the intracranial volume.
  
  
  RESULTS
  The relative SHM volume of the INPH group (0.0237 ± 0.0064) was the smallest among the 3 groups (AD: 0.0477 ± 0.0109, HV: 0.0542 ± 0.0045). The VS (0.0499 ± 0.0135) and SF (0.0187 ± 0.0037) volumes of the INPH group were significantly larger than those of the AD (VS: 0.0311 ± 0.0075, SF: 0.0146 ± 0.0026) and HV groups (VS: 0.0167 ± 0.0065, SF: 0.0111 ± 0.017).
  
  
  CONCLUSIONS
  Automatic volume measurement can be used to delineate the characteristic changes in CSF space in patients with INPH and is useful in the diagnosis of INPH.
authors: Department of Radiology, Kinki University Faculty of Medicine, Osakasayama, Tokyo, Japan ; Department of Radiology, Hyogo Brain and Heart Center, Himeji, Tokyo, Japan.
authors: Kazunari
authors: K
authors: Ishii
authors: Department of Radiology, The University of Tokyo, Tokyo, Japan ; Software Development Group, FUJIFILM RI Pharma Co. Ltd., Tokyo, Japan.
authors: Tsutomu
authors: T
authors: Soma
authors: Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center, Himeji, Tokyo, Japan.
authors: Kenichi
authors: K
authors: Shimada
authors: Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center, Himeji, Tokyo, Japan.
authors: Haruhiko
authors: H
authors: Oda
authors: Institute for Aging Brain and Cognitive Disorders, Hyogo Brain and Heart Center, Himeji, Tokyo, Japan.
authors: Akira
authors: A
authors: Terashima
authors: Department of Radiology, Hyogo Brain and Heart Center, Himeji, Tokyo, Japan.
authors: Ryota
authors: R
authors: Kawasaki
keywords: Cerebrospinal fluid space; Idiopathic normal pressure hydrocephalus; MRI; Ventricle system; Volumetry