title: PCP and septins compartmentalize cortical actomyosin to direct collective cell movement.
abstract: Despite our understanding of actomyosin function in individual migrating cells, we know little about the mechanisms by which actomyosin drives collective cell movement in vertebrate embryos. The collective movements of convergent extension drive both global reorganization of the early embryo and local remodeling during organogenesis. We report here that planar cell polarity (PCP) proteins control convergent extension by exploiting an evolutionarily ancient function of the septin cytoskeleton. By directing septin-mediated compartmentalization of cortical actomyosin, PCP proteins coordinate the specific shortening of mesenchymal cell-cell contacts, which in turn powers cell interdigitation. These data illuminate the interface between developmental signaling systems and the fundamental machinery of cell behavior and should provide insights into the etiology of human birth defects, such as spina bifida and congenital kidney cysts.
authors: Howard Hughes Medical Institute and University of Texas at Austin, Austin, TX 78712, USA.
authors: Asako
authors: A
authors: Shindo
authors: John B
authors: JB
authors: Wallingford
mesh_terms: D000205:Actomyosin / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000378:metabolism; D005260:Female; D005775:Gastrula / Q000166:cytology / Q000378:metabolism; D055785:Gene Knockdown Techniques; D006801:Humans; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism; D038081:Organogenesis; D010766:Phosphorylation; D058112:Septins / Q000235:genetics / Q000378:metabolism*; D029867:Xenopus Proteins / Q000235:genetics / Q000378:metabolism*; D014982:Xenopus laevis
chemical_list: D029867:Xenopus Proteins; D000205:Actomyosin; D058112:Septins; C552238:sept7 protein, Xenopus