title: Pregnancy Rate after First Intra Cytoplasmic Sperm Injection- In Vitro Fertilisation Cycle in Patients with Endometrioma with or without Deep Infiltrating Endometriosis.
abstract: BACKGROUND
  To evaluate the impact of the association of endometrioma with or without deep infiltrating endometriosis (DIE) after a first intra cytoplasmic sperm injection- in vitro fertilization (ICSI-IVF) cycle on pregnancy rate.
  
  
  METHODS
  In this retrospective study, women with endometrioma who underwent a first ICSI-IVF cycle from January 2007 to June 2010 were reviewed for pregnancy rate. The main outcome measure was the clinical pregnancy rate. A multiple logistic regression (MLR) was performed; including all variables that were correlated to the conception rate. Only independent factors of pregnancy rate were included in a Recursive Partitioning (RP) model.
  
  
  RESULTS
  The study population consisted of 104 patients (37 without DIE and 67 patients with associated DIE). Using multivariable analysis, a lower pregnancy rate was associated with the presence of DIE (OR=0.24 (95% CI: 0.085-0.7); p=0.009) and the use of ICSI (OR=0.23 (95% CI: 0.07-0.8); p=0.02). A higher pregnancy rate was associated with an anti-mullerian hormone (AMH) serum level over 1 ng/ml (OR=4.3 (95% CI: 1.1-19); p=0.049). A RP was built to predict pregnancy rate with good calibration [ROC AUC (95% CI) of 0.70 (0.65-0.75)].
  
  
  CONCLUSIONS
  Our data support that DIE associated with endometrioma in infertile patients has a negative impact on pregnancy rate after first ICSI-IVF cycle. Furthermore, our predictive model gives couples better information about the likelihood of conceiving.
authors: Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6 University, Paris, France.
authors: Anne
authors: A
authors: Oppenheimer
authors: Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6 University, Paris, France.
authors: Marcos
authors: M
authors: Ballester
authors: Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6 University, Paris, France.
authors: Emmanuelle
authors: E
authors: Mathieu d'Argent
authors: Department of Gynecology-Obstetrics, Rennes Hospital, Paris, France.
authors: Karine
authors: K
authors: Morcel
authors: Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6 University, Paris, France.
authors: Jean-Marie
authors: JM
authors: Antoine
authors: Department of Gynecology-Obstetrics, Tenon Hospital, GRC-UPMC 6 (C3E), Pierre et Marie Curie Paris 6 University, Paris, France.
authors: Emile
authors: E
authors: Daraï
keywords: Assisted Reproductive Technology; Endometrioma; Endometriosis; Probabilistic Model