title: A Long-term follow-up study of 91 cases with ovarian granulosa cell tumors.
abstract: OBJECTIVE
  To evaluate the prognostic factors of ovarian granulosa cell tumors (GCTs) and treatment outcomes in recurrent GCT cases.
  
  
  METHODS
  We retrospectively reviewed 91 patients with GCT who were treated in two tertiary Centers between 1989 and 2011.
  
  
  RESULTS
  Eighty patients had stage I tumors, five had stage II, and six had stage III. There were 15 cases of recurrence with a median follow-up time of 58 (3-254) months. Multivariate analysis identified greater tumor size and postoperative residual tumor as independent risk factors for recurrence. Twelve patients underwent secondary surgery at first recurrence. At a median follow-up of 50 (4-185) months from first recurrence, the 5-year survival was 60% for patients with and 100% for those without residual tumor after secondary surgery, respectively (p=0.018, log-rank test).
  
  
  CONCLUSIONS
  Complete cytoreduction is an important prognostic factor for recurrent cases as well as initial treatment of GCT.
authors: Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, 388-1, Pungnap-dong, Songpa-gu, Seoul 138-736, Republic of Korea. nastassja@naver.com.
authors: Seung-Hyuk
authors: SH
authors: Shim
authors: Sun Joo
authors: SJ
authors: Lee
authors: Dae-Yeon
authors: DY
authors: Kim
authors: Jin
authors: J
authors: Kim
authors: Soo-Nyung
authors: SN
authors: Kim
authors: Soon-Beom
authors: SB
authors: Kang
authors: Jong-Hyeok
authors: JH
authors: Kim
authors: Yong-Man
authors: YM
authors: Kim
authors: Young-Tak
authors: YT
authors: Kim
authors: Joo-Hyun
authors: JH
authors: Nam
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006106:Granulosa Cell Tumor / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000473:pathology*; D012372:ROC Curve; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
keywords: Granulosa cell tumor; cytoreduction; fertility-sparing surgery; prognosis; recurrence