title: Antitumour activity of Sargassum wightii (Greville) extracts against Dalton's ascites lymphoma.
abstract: Seaweeds have been used by mankind as medicine and food for more than 13,000 years. Marine algae are considered to produce a valuable phytoconstituents characterized by a broad spectrum of antitumor activities. The aim of the present study was to explore the effect of different solvent extracts of Sargassum wightii, Greville against Dalton's Ascitic Lymphoma (DAL) in Swiss male albino mice. DAL cells were injected intraperitoneally 1 x10(6) cell to the mice. Two days after cells injection the animals were treated with different solvent extracts of Sargassum wightii at dose of 200 mg kg(-1) for 14 days. 5-fluorouracil (20 mg kg(-1)) was used as reference drug. On day 11, cancer cell number, packed cell volume, decrease in tumour weight of the mice, increase in life span and hematological parameters were evaluated and compared with the same parameters in control. A significant increase in the life span and a decrease in the cancer cell number and tumour weight were noted in the tumour-induced mice after treatment with the extract. The haematological parameters were also normalized by the ethanolic and chloroform extracts in tumour-induced mice. These observations are suggestive of the protective effect of ethanolic extract of Sargassum wightii is comparatively better than other two tested extracts against Dalton's Ascitic Lymphoma (DAL).
authors: School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
authors: D Senthil
authors: DS
authors: Rajan
authors: Padmavathi College of Pharmacy and Research Institute, Tamilnadu, India.
authors: M
authors: M
authors: Rajkumar
authors: School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
authors: R
authors: R
authors: Srinivasan
authors: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
authors: R P
authors: RP
authors: Harikumar
authors: School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia.
authors: S
authors: S
authors: Suresh
authors: Padmavathi College of Pharmacy and Research Institute, Tamilnadu, India.
authors: Senthil
authors: S
authors: Kumar
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D008223:Lymphoma / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D044647:Sargassum / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012997:Solvents