title: Acute-phase reactants in periodontal disease: current concepts and future implications.
abstract: Periodontal disease has been linked to adverse cardiovascular events by unknown mechanisms. C-reactive protein is a systemic marker released during the acute phase of an inflammatory response and is a prognostic marker for cardiovascular disease, with elevated serum levels being reported during periodontal disease. Studies also reported elevated levels of various other acute-phase reactants in periodontal disease. It has been reported extensively in the literature that treatment of periodontal infections can significantly lower serum levels of C-reactive protein. Therefore, an understanding of the relationship between acute-phase response and the progression of periodontal disease and other systemic health complications would have a profound effect on the periodontal treatment strategies. In view of this fact, the present review highlights an overview of acute-phase reactants and their role in periodontal disease.
authors: Department of Periodontics, PMS College of Dental Science and Research, Thiruvananthapuram, India.
authors: Vilasan
authors: V
authors: Archana
authors: Ranjith
authors: R
authors: Ambili
authors: Krishnavilasam Jayakumary
authors: KJ
authors: Nisha
authors: Abraham
authors: A
authors: Seba
authors: Chandran
authors: C
authors: Preeja
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis* / Q000145:classification; D000210:Acute-Phase Reaction / Q000276:immunology; D002097:C-Reactive Protein / Q000032:analysis; D002318:Cardiovascular Diseases / Q000097:blood / Q000276:immunology; D018450:Disease Progression; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology; D010510:Periodontal Diseases / Q000097:blood* / Q000276:immunology
chemical_list: D000209:Acute-Phase Proteins; D018836:Inflammation Mediators; D002097:C-Reactive Protein
keywords: C-reactive protein; acute phase reactants; nonsurgical periodontal therapy; periodontal disease; systemic marker