title: Cellular and molecular structure as a unifying framework for whole-cell modeling.
abstract: Whole-cell modeling has the potential to play a major role in revolutionizing our understanding of cellular biology over the next few decades. A computational model of the entire cell would allow cellular biologists to integrate data from many disparate sources in a single consistent framework. Such a comprehensive model would be useful both for hypothesis testing and in the discovery of new behaviors that emerge from complex biological networks. Cellular and molecular structure can and should be a key organizing principle in a whole-cell model, connecting models across time and length scales in a multiscale approach. Here I present a summary of recent research centered around using molecular and cellular structure to model the behavior of cells.
authors: Department of Biophysics, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: eroberts@jhu.edu.
authors: Elijah
authors: E
authors: Roberts
mesh_terms: D002477:Cells / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D004058:Diffusion; D008954:Models, Biological; D008958:Models, Molecular