title: [The estrogen-like and antioxidant effects of pilose antler blood wine in female rats with ovariectomy].
abstract: OBJECTIVE
  To investigate whether pilose antler blood wine has the effects of estrogen-like activity and antioxidant in the ovariectomized (OVX) female rats.
  
  
  METHODS
  The rat model of oxidative stress was established by ovariectomy. The female rats were divided into 6 groups: normal control group, OVX group, base wine group, and 3 pilose antler blood wine treated OVX groups (low, medium and high dose of wine at a dose of 4.5 g/kg, 9.1 g/kg and 13.6 g/kg respectively). After the feeding of pilose antler blood wine (saline in control and OVX group) for 31 days, the serum estrodial level, serum superoxide dismutase (SOD), and the content of methane dicarboxylic aldehyde (MDA) were measured.
  
  
  RESULTS
  The one month treatment of daily drink of pilose antler blood wine could significantly promote the serum estrodial level in OVX rats (P < 0.05). Either low or medium dose could inhibit the decrease of serum SOD activity and the increase of MDA content in OVX rats, and the inhibition effects were more obvious in low dose group compared with high dose group (P < 0.05).
  
  
  CONCLUSIONS
  The daily drink of pilose antler blood wine showed the effects on increasing estrodial level and antioxidation in OVX rats.
authors: Center of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Qiang
authors: Q
authors: Gao
authors: Center of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Yang
authors: Y
authors: Yang
authors: Center of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Zeng-Chun
authors: ZC
authors: Sun
authors: Center of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Huau
authors: H
authors: Jiang
authors: Center of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Xue
authors: X
authors: Jia
authors: Center of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Ju-Lian
authors: JL
authors: Yuan
authors: Center of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Cheng-Qi
authors: CQ
authors: He
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry*; D000999:Antlers / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry; D004967:Estrogens / Q000737:chemistry*; D005260:Female; D008516:Medicine, Chinese Traditional; D010052:Ovariectomy; D018384:Oxidative Stress; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001688:Biological Products; D004967:Estrogens; D013482:Superoxide Dismutase