title: Efficient synthesis ofcis-2,6-di-(2- quinolylpiperidine).
abstract: An efficient synthesis ofcis-2,6-di-(2-quinolylpiperidine) has been developed. The key steps involve Wittig reaction ofN-Cbz-protectedcis-piperidine-2,6-dicarboxaldehyde (3) with 2-(triphenylphosphinyl- methyl)quinoline bromide (4) and sequential removal of theN-Cbz group and double bond reduction. This synthetic procedure provides an efficient preparation for this useful norlobelane analogue.
authors: Department of Pharmaceutical Science, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
authors: Derong
authors: D
authors: Ding
authors: Department of Pharmaceutical Science, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
authors: Linda P
authors: LP
authors: Dwoskin
authors: Department of Pharmaceutical Science, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA.
authors: Peter A
authors: PA
authors: Crooks
keywords: Lobelane; Swern oxidation; Wittig reaction; cis-2,6-di-(2-quinolylpiperidine); norlobelane analogues; quinlobelane