title: Protection effect of Xuanfudaizhetang on reflux esophagitis in rats.
abstract: OBJECTIVE
  To study protection effect of Xuanfudaizhetang on reflux esophagitis in rats.
  
  
  METHODS
  A total of 50 Wistar rats were randomly divided into groups A, B, C, D and E with 10 in each. Reflux esophagitis model in rats was established by incomplete helicobacter seam+lower esophagus sphincterotomy. All rats were divided into 5 groups: group A as control group, group B as model group, group C with saline lavage treatment, group D with motilium treatment, group E with Xuanfudaizhetang lavage treatment. Recovery of esophageal, gastric mucosa and pH changes of rats were compared between groups.
  
  
  RESULTS
  Weight gain in group D and E was significantly higher in than group C; the esophageal mucosa grades and esophagus tissue pathological morphology grades of group D and E were higher than that of group B and C with significant difference between groups (P<0.05); pH of lower esophageal mucosa in group D and E increased significantly than that in the group B and C (P<0.05), and the distal mucosal pH dropped significantly in the group B and C (P<0.05).
  
  
  CONCLUSIONS
  Xuanfudaizhetang can obviously improve the pH of lower esophageal mucosa in rats with reflux esophagitis, decrease pH value of gastric mucosal, thus improve esophageal mucosa pathological conditions to achieve therapeutic effect on reflux esophagitis.
authors: Department of Cardiothoracic Surgery, Huahe Hospital, Henan University, Kaifeng 475000, Henan, China.
authors: Bing
authors: B
authors: Liang
authors: Medical College, Henan University, Kaifeng 475000, Henan, China.
authors: Zhong-Hua
authors: ZH
authors: Liu
authors: Department of Cardiothoracic Surgery, Huahe Hospital, Henan University, Kaifeng 475000, Henan, China.
authors: Hai-Tao
authors: HT
authors: Wei
authors: Department of Cardiothoracic Surgery, Huahe Hospital, Henan University, Kaifeng 475000, Henan, China.
authors: Zhi
authors: Z
authors: Zhang
authors: Department of Cardiothoracic Surgery, Huahe Hospital, Henan University, Kaifeng 475000, Henan, China. Electronic address: liangbintg@163.com.
authors: Gong-Ning
authors: GN
authors: Shi
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D004947:Esophagus / Q000187:drug effects* / Q000473:pathology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D008297:Male; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D005765:Gastrointestinal Agents; D020011:Protective Agents
keywords: Esophageal mucosa; PH value; Reflux esophagitis; Treatment; Xuanfudaizhetang