title: Metachronous lung cancer--case presentation.
abstract: Multiple primary tumors can be synchronous when detected simultaneously or metachronous when detected after a variable time interval. We present the case of a 62-year-old female patient with a history of keratinized squamous cell carcinoma of the cervix, stage T3bNxM, operated, and treated by chemotherapy and radiation therapy which develops after three years a large cell neuroendocrine carcinoma of the lung detected by imaging. Of major importance in the selection of the optimal therapeutic approach was the accurate determination of the histological type of the metachronous tumor by microscopy and immunohistochemical techniques. The discrete respiratory symptoms and the absence of lung imaging screening accounted for tumor development to an inoperable stage, thus emphasizing the importance of close monitoring of the oncologic patient, thus greatly increasing their chances of survival.
authors: Discipline of Medical Semiology, Rehabilitation Clinical Hospital, Iasi.
authors: Doina-Clementina
authors: DC
authors: Cojocaru
authors: Cardiovascular Rehabilitation Clinic, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: Corina
authors: C
authors: Dima-Cozma
authors: Pulmonary Rehabilitation Clinic, University of Medicine and Pharmacy "Grigore T. Popa"- Iasi.
authors: Paraschiva
authors: P
authors: Postolache
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D018287:Carcinoma, Large Cell / Q000175:diagnosis* / Q000188:drug therapy; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D057210:Delayed Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000188:drug therapy; D017239:Paclitaxel / Q000627:therapeutic use; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000601:surgery
chemical_list: D016190:Carboplatin; D017239:Paclitaxel