title: CNS vasculitis and stroke in neonatal lupus erythematosus: a case report and review of literature.
abstract: Neonatal lupus erythematosus refers to the clinical spectrum of cardiac, cutaneous and other systemic abnormalities in neonates born to mothers with autoantibodies against Ro/SSA and La/SSB antigens. Isolated central nervous system involvement is very rare and has been described as transient vasculopathy only. We describe a 2-months-old girl who presented with acute ischemic stroke secondary to central nervous system vasculitis without any cardiac, cutaneous or hematological manifestations. The mother was pauci-symptomatic with raised anti-Ro autoantibody titers; the baby was positive for autoantibodies against Ro-antigen. Angiography confirmed vasculitis in cerebral vasculature. Our case highlights that neonatal lupus erythematosus can present with isolated nervous system manifestations and the vascular damage can be permanent in the form of vasculitis. Early recognition will help pediatricians identify such possible permanent complications in newborns with neonatal lupus erythematosus. A review of previously reported central nervous system manifestations of neonatal lupus is also presented.
authors: Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
authors: Arushi G
authors: AG
authors: Saini
authors: Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
authors: Naveen
authors: N
authors: Sankhyan
authors: Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
authors: Sagar
authors: S
authors: Bhattad
authors: Department of Radiodiagnosis, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
authors: Sameer
authors: S
authors: Vyas
authors: Department of Immunopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India.
authors: Biman
authors: B
authors: Saikia
authors: Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh 160012, India. Electronic address: doctorpratibhasinghi@gmail.com.
authors: Pratibha
authors: P
authors: Singhi
mesh_terms: D001323:Autoantibodies / Q000276:immunology; D005260:Female; D006801:Humans; D007223:Infant; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000151:congenital* / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D009035:Mothers; D020521:Stroke / Q000150:complications / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D020293:Vasculitis, Central Nervous System / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000473:pathology*
chemical_list: D001323:Autoantibodies
keywords: Congenital heart block; Neonatal lupus; Stroke; Vasculitis; Vasculopathy