title: Salecan diet increases short chain fatty acids and enriches beneficial microbiota in the mouse cecum.
abstract: Salecan, a linear extracellular polysaccharide consisting of β-(1,3)-D-glucan, has potential applications in the food industry due to its excellent toxicological profile and rheological properties. The aim of the present study was to evaluate the effects of dietary supplementation with 8% Salecan on the gastrointestinal microbiota in mice. In the Salecan group, the following significant differences (p<0.05) from the cellulose group were found: increased body weight gain, greater mass of cecum and cecal contents, and higher butyrate concentrations in the cecal and colonic contents at wk 4. Moreover, populations of Lactobacillus and Bifidobacterium increased 3- and 6-fold, respectively, in the cecal contents of mice consuming Salecan. These results suggest that the dietary incorporation of Salecan, by providing SCFAs and increasing beneficial microbiota, may be beneficial in improving gastrointestinal health, and have relevance to the use of Salecan as a dietary supplement for human consumption.
authors: Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: zhoumengyi1986@gmail.com.
authors: Mengyi
authors: M
authors: Zhou
authors: College of Life Science, Nanjing Agricultural University, 1 Weigang Street, Nanjing 210095, China. Electronic address: 2010116049@njau.edu.cn.
authors: Chuanliang
authors: C
authors: Pu
authors: Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: xialinfzdx@126.com.
authors: Lin
authors: L
authors: Xia
authors: Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: yu198891@sina.com.
authors: Xiaohong
authors: X
authors: Yu
authors: Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: zhubin960311@163.com.
authors: Bin
authors: B
authors: Zhu
authors: Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: chengrui.1988@163.com.
authors: Rui
authors: R
authors: Cheng
authors: Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China. Electronic address: xulinxiang1988@yahoo.cn.
authors: Linxiang
authors: L
authors: Xu
authors: Center for Molecular Metabolism, Nanjing University of Science & Technology, 200 Xiaolingwei Street, Nanjing 210094, China; College of Life Science, Nanjing University, 22 Hankou Road, Nanjing 210093, China. Electronic address: jfzhang@mail.njust.edu.cn.
authors: Jianfa
authors: J
authors: Zhang
mesh_terms: D000818:Animals; D001419:Bacteria / Q000145:classification; D002432:Cecum / Q000382:microbiology*; D004032:Diet; D004591:Electrophoresis, Polyacrylamide Gel; D005232:Fatty Acids, Volatile / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D064307:Microbiota; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D015430:Weight Gain; D047071:beta-Glucans / Q000008:administration & dosage*
chemical_list: D005232:Fatty Acids, Volatile; D047071:beta-Glucans; C577623:salecan
keywords: Bifidobacteria; Lactobacilli; Mice; PCR-DGGE; SCFA; Salecan