title: Perioperative renal function and surgical outcome.
abstract: OBJECTIVE
  A large proportion of patients undergoing surgery have coexisting chronic kidney disease, placing them at greater risk of postoperative morbidity and mortality. The purpose of this review is to review the recent developments in how renal function is estimated, how this relates to surgical outcomes, and how this has been applied clinically.
  
  
  RESULTS
  Recent developments in defining chronic kidney disease have coincided with an increased recognition of the prognostic importance of even mild preoperative renal dysfunction and the incorporation of more refined estimates of renal function into one of the most widely used risk prediction scores for cardiac surgery. In addition, several novel markers appear to hold promise as better predictors of perioperative outcome in general and acute kidney injury in particular.
  
  
  CONCLUSIONS
  Improved accuracy in defining kidney disease will aid clinicians in identifying higher risk patients, and aid earlier diagnosis of acute kidney injury. Further research is required, specifically on the implications of kidney disease in noncardiac surgical patients, and how defining renal function before and after surgery can aid in preventive strategies.
authors: aThe George Institute for Global Health/University of Sydney bWestmead Hospital cConcord Repatriation General Hospital, Sydney, New South Wales, Australia.
authors: John F
authors: JF
authors: Mooney
authors: Clara K
authors: CK
authors: Chow
authors: Graham S
authors: GS
authors: Hillis
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis; D000209:Acute-Phase Proteins; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood; D019990:Perioperative Care; D011183:Postoperative Complications / Q000175:diagnosis; D015995:Prevalence; D011518:Proto-Oncogene Proteins / Q000097:blood; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology; D013514:Surgical Procedures, Operative
chemical_list: D000209:Acute-Phase Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins