title: Co-translational protein targeting to the bacterial membrane.
abstract: Co-translational protein targeting by the Signal Recognition Particle (SRP) is an essential cellular pathway that couples the synthesis of nascent proteins to their proper cellular localization. The bacterial SRP, which contains the minimal ribonucleoprotein core of this universally conserved targeting machine, has served as a paradigm for understanding the molecular basis of protein localization in all cells. In this review, we highlight recent biochemical and structural insights into the molecular mechanisms by which fundamental challenges faced by protein targeting machineries are met in the SRP pathway. Collectively, these studies elucidate how an essential SRP RNA and two regulatory GTPases in the SRP and SRP receptor (SR) enable this targeting machinery to recognize, sense and respond to its biological effectors, i.e. the cargo protein, the target membrane and the translocation machinery, thus driving efficient and faithful co-translational protein targeting. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey.
authors: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: ishu@iiserb.ac.in.
authors: Ishu
authors: I
authors: Saraogi
authors: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: sshan@caltech.edu.
authors: Shu-ou
authors: SO
authors: Shan
mesh_terms: D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000235:genetics / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D011485:Protein Binding; D014176:Protein Biosynthesis / Q000235:genetics*; D011487:Protein Conformation; D021381:Protein Transport / Q000235:genetics*; D018271:Signal Recognition Particle / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D018271:Signal Recognition Particle; D020558:GTP Phosphohydrolases
keywords: GTPases; Molecular recognition and regulation; Protein targeting; Ribosome; SecYEG