title: CD81 and hepatitis C virus (HCV) infection.
abstract: Hepatitis C Virus (HCV) infection is a global public health problem affecting over 160 million individuals worldwide. Its symptoms include chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. HCV is an enveloped RNA virus mainly targeting liver cells and for which the initiation of infection occurs through a complex multistep process involving a series of specific cellular entry factors. This process is likely mediated through the formation of a tightly orchestrated complex of HCV entry factors at the plasma membrane. Among HCV entry factors, the tetraspanin CD81 is one of the best characterized and it is undoubtedly a key player in the HCV lifecycle. In this review, we detail the current knowledge on the involvement of CD81 in the HCV lifecycle, as well as in the immune response to HCV infection.
authors: Center for Infection and Immunity of Lille, CNRS-UMR8204, Inserm-U1019, Institut Pasteur de Lille, Université Lille Nord de France, Institut de Biologie de Lille, 1 rue du Pr Calmette, CS50447, 59021 Lille Cedex, France. lucie.feneant@ibl.fr.
authors: Lucie
authors: L
authors: Fénéant
authors: Department of Medicine, Division of Oncology, CCSR, Stanford University Medical Center, Stanford, CA 94305, USA. slevy@stanford.edu.
authors: Shoshana
authors: S
authors: Levy
authors: Center for Infection and Immunity of Lille, CNRS-UMR8204, Inserm-U1019, Institut Pasteur de Lille, Université Lille Nord de France, Institut de Biologie de Lille, 1 rue du Pr Calmette, CS50447, 59021 Lille Cedex, France. laurence.cocquerel@ibl.fr.
authors: Laurence
authors: L
authors: Cocquerel
mesh_terms: D016174:Hepacivirus / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008954:Models, Biological; D011991:Receptors, Virus / Q000378:metabolism*; D060225:Tetraspanin 28 / Q000378:metabolism*; D053586:Virus Internalization
chemical_list: C554798:CD81 protein, human; D011991:Receptors, Virus; D060225:Tetraspanin 28