title: Near full-length genome sequence of a novel HIV-1 recombinant form (CRF01_AE/B) detected among men who have sex with men in Jilin Province, China.
abstract: We report here a novel HIV-1 recombinant form (CRF01_AE/B) detected from a comprehensive HIV-1 molecular epidemiologic study among men who have sex with men (MSM) in Jilin province of northeastern China. The near full-length genome (NFLG) analyses showed that the novel HIV-1 recombinant isolate (JL.RF07) was composed of CRF01_AE cluster 5 (northeastern China origin) and subtype B (U.S. and European origin), with six recombinant breakpoints observed in the pol, vif, tat, rev, and env gene regions. To the best of our knowledge, this is the first detection of a novel HIV-1 recombinant form (CRF01_AE/B) in Jilin, which may indicate an active transmission network of HIV-1 infection among MSM in the region. Further studies of the molecular epidemiology of the HIV-1 epidemic among MSM in northeastern China are necessary to gain a fuller understanding of the transmission network and potential public health impact of HIV-1 among MSM in this region.
authors: 1 State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases , Beijing, China .
authors: Xingguang
authors: X
authors: Li
authors: Yi
authors: Y
authors: Feng
authors: Yao
authors: Y
authors: Yang
authors: Yanli
authors: Y
authors: Chen
authors: Qi
authors: Q
authors: Guo
authors: Liuyan
authors: L
authors: Sun
authors: Xihui
authors: X
authors: Zang
authors: Hui
authors: H
authors: Xing
authors: Yiming
authors: Y
authors: Shao
mesh_terms: D001483:Base Sequence; D018791:CD4 Lymphocyte Count; D002681:China / Q000453:epidemiology; D014644:Genetic Variation; D016679:Genome, Viral / Q000235:genetics*; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic; D016415:Sequence Alignment; D017423:Sequence Analysis, RNA
chemical_list: D012367:RNA, Viral