title: High field dynamic nuclear polarization NMR with surfactant sheltered biradicals.
abstract: We illustrate the ability to place a water-insoluble biradical, bTbk, into a glycerol/water matrix with the assistance of a surfactant, sodium octyl sulfate (SOS). This surfactant approach enables a previously water insoluble biradical, bTbk, with favorable electron-electron dipolar coupling to be used for dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) experiments in frozen, glassy, aqueous media. Nuclear Overhauser enhancement (NOE) and paramagnetic relaxation enhancement (PRE) experiments are conducted to determine the distribution of urea and several biradicals within the SOS macromolecular assembly. We also demonstrate that SOS assemblies are an effective approach by which mixed biradicals are created through an assembly process.
authors: Department of Chemistry and ‡Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors: Matthew K
authors: MK
authors: Kiesewetter
authors: Vladimir K
authors: VK
authors: Michaelis
authors: Joseph J
authors: JJ
authors: Walish
authors: Robert G
authors: RG
authors: Griffin
authors: Timothy M
authors: TM
authors: Swager
mesh_terms: D017738:Alkanesulfonic Acids / Q000737:chemistry; D003497:Cyclic N-Oxides / Q000737:chemistry*; D004583:Electrons; D005990:Glycerol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry; D012995:Solubility; D013141:Spiro Compounds / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D013997:Time Factors; D014508:Urea / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: C521769:1-(TEMPO-4-oxy)-3-(TEMPO-4-amino)propan-2-ol; D017738:Alkanesulfonic Acids; D003497:Cyclic N-Oxides; D020005:Propanols; C000592861:SPIROPOL biradical; D013141:Spiro Compounds; D013501:Surface-Active Agents; C543204:bis-TEMPO-bisketal; D014867:Water; D014508:Urea; C042005:1-octanesulfonic acid; D005990:Glycerol; C003959:TEMPO