title: Effect of VEGF, P53 and telomerase on angiogenesis of gastric carcinoma tissue.
abstract: OBJECTIVE
  To investigate the effect of vascular endothelial growth factor (VEGF), P53 and telomerase on angiogenesis in gastric carcinoma tissue.
  
  
  METHODS
  A total of 95 surgical resection samples of gastric cancer tissue after pathological diagnosis are collected to observe the VEGF, P53 and telomerase expression using immunohistochemical methods. Relationship between their expression and its influence on angiogenesis in gastric carcinoma tissue were analyzed.
  
  
  RESULTS
  Microvascular density (MVD) and the expression of VEGF, P53 and telomerase were positively correlated. Expression of VEGF and P53 protein were related to tumor type and lymph metastasis, and also a correlation was observed between P53 and VEGF. The telomerase expression had no correlation with VEGF, and P53.
  
  
  CONCLUSIONS
  VEGF angiogenesis has a angiogenesis promoting effect on gastric cancer tissue development and plays an important role in tumor generation and metastasis. Mutant P53 promotes the tumor angiogenesis generation by adjusting VEGF. Telomerase has a certain role in promoting activity of angiogenesis through different way rather than P53.
authors: Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei, China. Electronic address: yyfangtg@163.com.
authors: Yan-Fang
authors: YF
authors: Yu
authors: Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei, China.
authors: Yong
authors: Y
authors: Zhang
authors: Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei, China.
authors: Na
authors: N
authors: Shen
authors: Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei, China.
authors: Rui-Ying
authors: RY
authors: Zhang
authors: Affiliated Hospital of Hebei University of Engineering, Handan 056002, Hebei, China.
authors: Xin-Qing
authors: XQ
authors: Lu
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D019098:Telomerase / Q000737:chemistry / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000737:chemistry / Q000378:metabolism*
chemical_list: C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D019098:Telomerase
keywords: Angiogenesis; Gastric carcinoma; P53; Telomerase; VEGF