title: Individualized treatment in stage IVC nasopharyngeal carcinoma.
abstract: The stage IVC nasopharyngeal carcinoma is a catch-all entity covering minute solitary metastasis to bulky disseminated disease. Prognosis varies greatly within this stage group. A subset of patients with oligometastases may benefit from aggressive local ablative therapy. Meanwhile, in multiple metastatic diseases, customizing conventional cytotoxics basing on individual tumor characteristics and previous chemotherapy responses can be a new direction to improve therapeutic results. Prognostic models built on clinical features and genomic profiles can be utilized to stratify different risk groups and tailor therapy schemes.
authors: Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong.
authors: Oscar S H
authors: OS
authors: Chan
authors: Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong. Electronic address: ngankc@ha.org.hk.
authors: Roger K C
authors: RK
authors: Ngan
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000473:pathology / Q000628:therapy* / Q000821:virology; D009362:Neoplasm Metastasis; D010166:Palliative Care
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor