title: Highly hemocompatible zwitterionic micelles stabilized by reversible cross-linkage for anti-cancer drug delivery.
abstract: Both blood stability and intelligent-responsiveness after reaching the drug-targeting site are very important features to make desirable nano-drug vehicles (NDVs). Here, a highly nonfouling cross-linked micelle based on a copolymer composed of carboxybetaine methacrylate (CBMA) as hydrophilic segment and 2-(methacryloyloxy)ethyl lipoate (MAEL) as hydrophobic and cross-linked segment is reported. Furthermore, a simple method to evaluate the hemocompatibility of NDVs through examining the activation of a blood-clotting protein (fibrinogen) was introduced. The micelles can encapsulate anticancer drug doxorubicin (DOX) conveniently and release DOX quickly in response to an intracellular reductive environment. With the advantages of excellent stability in fibrinogen (1 mg/mL) PBS solution and 50% fetal bovine serum (FBS), and accelerated intracellular drug release, the biocompatible zwitterionic micelles stabilized by reversible cross-linkage might be a promising drug carrier for cancer chemotherapy.
authors: State Key Laboratory of Chemical Engineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Weifeng
authors: W
authors: Lin
authors: State Key Laboratory of Chemical Engineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Yueying
authors: Y
authors: He
authors: State Key Laboratory of Chemical Engineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Juan
authors: J
authors: Zhang
authors: State Key Laboratory of Chemical Engineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Longgang
authors: L
authors: Wang
authors: State Key Laboratory of Chemical Engineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Zhen
authors: Z
authors: Wang
authors: State Key Laboratory of Chemical Engineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China.
authors: Fangqin
authors: F
authors: Ji
authors: State Key Laboratory of Chemical Engineering and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, PR China. Electronic address: schen@zju.edu.cn.
authors: Shengfu
authors: S
authors: Chen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001622:Betaine / Q000138:chemical synthesis / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D019556:COS Cells; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004317:Doxorubicin / Q000494:pharmacology*; D016503:Drug Delivery Systems; D005340:Fibrinogen / Q000378:metabolism; D008823:Micelles; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D008823:Micelles; D011109:Polymethacrylic Acids; C517178:polycarboxybetaine methacrylate; D001622:Betaine; D004317:Doxorubicin; D005340:Fibrinogen
keywords: Blood compatibility; Nonfouling; Reversible cross-linked micelles; Zwitterionic