title: Adenylyl cyclases in the digestive system.
abstract: Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals. In addition to the transmembrane isoforms, one AC is soluble and exhibits distinct regulation. In this review, the basic structure, regulation and physiological roles of ACs in the digestive system are discussed.
authors: Department of Biological Sciences, Georgia Regents University, United States. Electronic address: msabbatini@gru.edu.
authors: Maria Eugenia
authors: ME
authors: Sabbatini
authors: Department of Cell Biology and Medicine, Yale University, United States; VA CT, United States.
authors: Fred
authors: F
authors: Gorelick
authors: Department of Internal Medicine, Scott & White-Digestive Disease Research Center, Texas A&M Health Science Center, Central Texas Veterans Health Care System, United States.
authors: Shannon
authors: S
authors: Glaser
mesh_terms: D000262:Adenylyl Cyclases / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D020134:Catalytic Domain; D004064:Digestive System / Q000201:enzymology*; D004068:Digestive System Physiological Phenomena / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000502:physiology; D010195:Pancreatitis / Q000201:enzymology; D015398:Signal Transduction
chemical_list: D007527:Isoenzymes; D000262:Adenylyl Cyclases
keywords: Adenylyl cyclase; Exocrine pancreas; Intestine; Liver; Salivary gland; Stomach