title: Preliminary study with SprayShield™ Adhesion Barrier System in the prevention of abdominal adhesions.
abstract: BACKGROUND
  Peritoneal adhesions, the fibrotic bands that form between the surfaces in the peritoneal cavity following surgery, still pose a difficult clinical challenge.
  
  
  OBJECTIVE
  To evaluate the SprayShield™ Adhesion Barrier System (PEG ester amine solution and a buffer solution) in reducing post-operative adhesion formation.
  
  
  METHODS
  This was a prospective, multi-center, randomized, single blind study. A total of 11 subjects diagnosed with ulcerative colitis (UC) or familial adenomatous polyposis (FAP) were randomized: 8 to the SprayShield™ arm and 3 to the control arm. SprayShield™ was applied on the viscera directly under the midline peritoneal incision and at the site of ileostomy. During the follow-up surgery, the incidence, extent, and severity of post-operative adhesion formation were evaluated, as well as the time required to mobilize the ileal loop.
  
  
  RESULTS
  In patients who received SprayShield™ the time required to mobilize the ileal loop at the ileostomy closure was slightly shorter and the incidence and severity of adhesions were somewhat lower vs. control subjects (NS).
  
  
  CONCLUSIONS
  SprayShield™ was found to be easy to use, safe, and quick to apply, and performed well in adherence and conformity. The incidence and severity of adhesions were lower for SprayShield™ subjects vs. control subjects, but due to the limited number of patients there are not enough data to confirm the effectiveness of the SprayShield™ Adhesion Barrier System in prevention of adhesions.
authors: Department of General Surgery, Gastroenterological Oncological Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland.
authors: Tomasz
authors: T
authors: Banasiewicz
authors: Department of General and Colorectal Surgery, Poznan University of Medical Sciences, Poznan, Poland.
authors: Karolina
authors: K
authors: Horbacka
authors: Department of General and Colorectal Surgery, Poznan University of Medical Sciences, Poznan, Poland.
authors: Jacek
authors: J
authors: Karoń
authors: Department of General Surgery, Gastroenterological Oncological Surgery and Plastic Surgery, Poznan University of Medical Sciences, Poznan, Poland.
authors: Stanisław
authors: S
authors: Malinger
authors: Department of Surgery, Faculty Hospital Na Bulovce, Praha, Czech Republic.
authors: Frantisek
authors: F
authors: Antos
authors: First Chair and Department of General, Transplant Surgery and Clinical Nutrition, University of Medical Sciences, Lublin, Poland.
authors: Sławomir
authors: S
authors: Rudzki
authors: Department of Surgery, Faculty Hospital Bohunice, Brno, Czech Republic.
authors: Zdenek
authors: Z
authors: Kala
authors: Department of General, Vascular and Oncological Surgery, Regional Hospital Slupsk; Department of Oncological Surgery, Medical University of Gdansk, Gdansk, Poland.
authors: Zoran
authors: Z
authors: Stojcev
authors: Department of Surgery, Päijät-Häme Central Hospital, Lahti, Finland.
authors: Jyrki
authors: J
authors: Kössi
authors: Department of General and Colorectal Surgery, Poznan University of Medical Sciences, Poznan, Poland.
authors: Piotr
authors: P
authors: Krokowicz
keywords: adhesion prevention; adhesions; ileostomy; laparotomy