title: Evolving blood pressure dynamics for extremely preterm infants.
abstract: OBJECTIVE
  To examine changes in arterial blood pressure (ABP) after birth in extremely preterm infants.
  
  
  METHODS
  Prospective observational study of infants 23(0/7) to 26(6/7) weeks gestational age (GA). Antihypotensive therapy use and ABP measurements were recorded for the first 24 h.
  
  
  RESULTS
  A cohort of 367 infants had 18 709 ABP measurements recorded. ABP decreased for the first 3 h, reached a nadir at 4 to 5 h and then increased at an average rate of 0.2 mm Hg h(-1). The rise in ABP from hour 4 to 24 was similar for untreated infants (n=164) and infants given any antihypotensive therapy (n=203), a fluid bolus (n=135) or dopamine (n=92). GA-specific trends were similar. ABP tended to be lower as GA decreased, but varied widely at each GA.
  
  
  CONCLUSIONS
  ABP increased spontaneously over the first 24 postnatal hours for extremely preterm infants. The rate of rise in ABP did not change with antihypotensive therapy.
authors: 1] Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA [2] Department of Pediatrics, Southern Illinois University School of Medicine, Springfield, IL, USA.
authors: B
authors: B
authors: Batton
authors: Statistics and Epidemiology Unit, RTI International, Research Triangle Park, NC, USA.
authors: L
authors: L
authors: Li
authors: Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
authors: N S
authors: NS
authors: Newman
authors: Statistics and Epidemiology Unit, RTI International, Rockville, MD, USA.
authors: A
authors: A
authors: Das
authors: Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
authors: K L
authors: KL
authors: Watterberg
authors: Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors: B A
authors: BA
authors: Yoder
authors: Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, USA.
authors: R G
authors: RG
authors: Faix
authors: Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
authors: M M
authors: MM
authors: Laughon
authors: Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.
authors: B J
authors: BJ
authors: Stoll
authors: Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
authors: R D
authors: RD
authors: Higgins
authors: Division of Neonatology, Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University, Cleveland, OH, USA.
authors: M C
authors: MC
authors: Walsh
mesh_terms: D062186:Arterial Pressure / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D007022:Hypotension / Q000188:drug therapy; D062071:Infant, Extremely Premature / Q000502:physiology*; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies