title: Preliminary study of the association of white-matter metabolite concentrations with disease severity in patients with Huntington's disease.
abstract: Proton magnetic resonance spectroscopy is used to measure several metabolites in cortical gray and white matter in patients with Huntington's disease. The preliminary results show that CAG-repeat length correlates with white-matter N-acetylaspartate concentrations, and disease severity correlates with several metabolites.
authors: Jeffrey R
authors: JR
authors: Yager
authors: Charles
authors: C
authors: Gasparovic
authors: Vincent A
authors: VA
authors: Magnotta
authors: William
authors: W
authors: Adams
authors: Jess
authors: J
authors: Fiedorowicz
authors: Jane
authors: J
authors: Paulsen
authors: Ricardo
authors: R
authors: Jorge
authors: Leigh J
authors: LJ
authors: Beglinger
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D006816:Huntington Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009413:Nerve Fibers, Myelinated / Q000378:metabolism*; D011522:Protons; D018911:Trinucleotide Repeats / Q000235:genetics
chemical_list: D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate