title: Widespread bullous fixed drug eruption.
abstract: A 53-year-old man developed a widespread erythematous eruption which rapidly evolved into fluid-filled bulla mostly involving the distal areas of all four limbs and erosions on the oral as well as anogenital mucosa. Based on clinical presentation, chronology of drug exposure, past events and histopathology as diagnosis of widespread bullous fixed drug eruption was made over Steven Johnson-toxic epidermal necrolysis syndrome. Steroids were deferred and the lesions healed with minimal pigmentation within a week. Differentiating between the two entities has been historically difficult, and yet can have significant therapeutic and prognostic implications.
authors: Department of Medicine, Medical College Baroda, Vadodara, Gujarat, India.
authors: Rushad D
authors: RD
authors: Patell
authors: Rupal V
authors: RV
authors: Dosi
authors: Purav C
authors: PC
authors: Shah
authors: Harshal S
authors: HS
authors: Joshi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D001768:Blister / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D004008:Diclofenac / Q000009:adverse effects; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac