title: In vivo study of endometriosis in mice by photoacoustic microscopy.
abstract: Endometriosis (EM) impacts the healthcare and the quality of life for women of reproductive age. However, there is no reliable noninvasive diagnosis method for either animal study or clinical use. In this work, a novel imaging method, photoacoustic microscopy (PAM) was employed to study the EM on the mouse model. Our results demonstrated the PAM noninvasively provided the high contrast and 3D imaging of subcutaneously implanted EM tissue in the nude mouse in vivo. The statistical study also indicated PAM had high sensitivity and specificity in the diagnosis of EM in this animal study. In addition, we also discussed the potential clinical application for PAM in the diagnosis of EM.
authors: Department of Biomedical Engineering, College of Engineering, Peking University, No. 5 Yiheyuan Road, Beijing, 100871, China.
authors: Yichen
authors: Y
authors: Ding
authors: Mingzhu
authors: M
authors: Zhang
authors: Jinghe
authors: J
authors: Lang
authors: Jinhua
authors: J
authors: Leng
authors: Qiushi
authors: Q
authors: Ren
authors: Jie
authors: J
authors: Yang
authors: Changhui
authors: C
authors: Li
mesh_terms: D000818:Animals; D004715:Endometriosis / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D051379:Mice; D008819:Mice, Nude; D008853:Microscopy / Q000295:instrumentation / Q000379:methods*; D061088:Photoacoustic Techniques / Q000295:instrumentation / Q000379:methods*
keywords: biomedical optics; endometriosis; optical imaging; photoacoustic microscopy