title: Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders.
abstract: BACKGROUND
  Repetitive Transcranial Magnetic Stimulation (rTMS)/ Deep-brain Magnetic Stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and cellular mechanisms underlying the impacts of rTMS/DMS on the brain are not yet fully understood.
  
  
  RESULTS
  Here we studied the effects of deep-brain magnetic stimulation to brain on the molecular and cellular level. We examined the adult hippocampal neurogenesis and hippocampal synaptic plasticity of rodent under stress conditions with deep-brain magnetic stimulation treatment. We found that DMS promotes adult hippocampal neurogenesis significantly and facilitates the development of adult new-born neurons. Remarkably, DMS exerts anti-depression effects in the learned helplessness mouse model and rescues hippocampal long-term plasticity impaired by restraint stress in rats. Moreover, DMS alleviates the stress response in a mouse model for Rett syndrome and prolongs the life span of these animals dramatically.
  
  
  CONCLUSIONS
  Deep-brain magnetic stimulation greatly facilitates adult hippocampal neurogenesis and maturation, also alleviates depression and stress-related responses in animal models.
authors: Yan
authors: Y
authors: Zhang
authors: Rong-Rong
authors: RR
authors: Mao
authors: Zhi-Fang
authors: ZF
authors: Chen
authors: Meng
authors: M
authors: Tian
authors: Da-Li
authors: DL
authors: Tong
authors: Zheng-Run
authors: ZR
authors: Gao
authors: Min
authors: M
authors: Huang
authors: Xiao
authors: X
authors: Li
authors: Xiu
authors: X
authors: Xu
authors: Wen-Hao
authors: WH
authors: Zhou
authors: Cheng-Yu
authors: CY
authors: Li
authors: Jiang
authors: J
authors: Wang
authors: Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. lxu@vip.163.com.
authors: Lin
authors: L
authors: Xu
authors: Zilong
authors: Z
authors: Qiu
mesh_terms: D000375:Aging / Q000473:pathology; D000818:Animals; D001007:Anxiety / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D001522:Behavior, Animal; D049109:Cell Proliferation; D018891:Dentate Gyrus / Q000473:pathology; D003863:Depression / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006624:Hippocampus / Q000166:cytology* / Q000473:pathology / Q000503:physiopathology; D060526:Magnetic Fields; D001523:Mental Disorders / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D058953:Neural Stem Cells / Q000166:cytology; D055495:Neurogenesis; D009473:Neuronal Plasticity; D010641:Phenotype; D051381:Rats; D017207:Rats, Sprague-Dawley; D015518:Rett Syndrome / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013315:Stress, Psychological / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D013569:Synapses / Q000473:pathology; D050781:Transcranial Magnetic Stimulation