title: Extramammary Paget disease successfully treated with topical imiquimod 5% and tazarotene.
abstract: Extramammary Paget disease (EMPD) is an intraepithelial adenocarcinoma usually localized in areas rich in apocrine sweat glands. Surgery remains the treatment of choice for EMPD. However, several nonsurgical treatments have been also described. Around 40 cases of EMPD treated with imiquimod 5% have been published; of these, only six correspond to nonresponses. We describe a recurrent vulvar EMPD with failure to respond to topical imiquimod 5% in monotherapy but a favorable response to its association with tazarotene.
authors: Department of Dermatology, Hospital General Universitario, Alicante, Spain.
authors: Laura
authors: L
authors: Frances
authors: Jose C
authors: JC
authors: Pascual
authors: Maria
authors: M
authors: Leiva-Salinas
authors: Isabel
authors: I
authors: Betlloch
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000634:Aminoquinolines / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D000077271:Imiquimod; D009539:Nicotinic Acids / Q000008:administration & dosage*; D010145:Paget Disease, Extramammary / Q000188:drug therapy*; D012176:Retinoids
chemical_list: D000634:Aminoquinolines; D000077271:Imiquimod; D009539:Nicotinic Acids; C086827:tazarotene; D012176:Retinoids
keywords: extrammamary Paget disease; imiquimod; tazarotene