title: Pregnancy loss following coxsackievirus b3 infection in mice during early gestation due to high expression of coxsackievirus-adenovirus receptor (CAR) in uterus and embryo.
abstract: Coxsackieviruses are important pathogens in children and the outcomes of neonatal infection can be serious or fatal. However, the outcomes of coxsackievirus infection during early gestation are not well defined. In this study, we examined the possibility of vertical transmission of coxsackievirus B3 (CVB3) and the effects of CVB3 infection on early pregnancy of ICR mice. We found that the coxsackievirus and adenovirus receptor (CAR) was highly expressed not only in embryos but also in the uterus of ICR mice. CVB3 replicated in the uterus 1 to 7 days post-infection (dpi), with the highest titer at 3 dpi. The pregnancy loss rate in mice infected with CVB3 during early gestation was 38.3%, compared to 4.7% and 2.7% in mock-infected and UV-inactivated-CVB3 infected pregnant mice, respectively. These data suggest that the uterus and embryo, which express abundant CAR, are important targets of CVB3 and that the vertical transmission of CVB3 during early gestation induces pregnancy loss.
authors: Department of Microbiology, College of Medicine, Yeungnam University, 170 Hyeonchung-ro, Namgu, Daegu 705-717, Republic of Korea.
authors: Ji Young
authors: JY
authors: Hwang
authors: Kyung Min
authors: KM
authors: Lee
authors: Yun Hwa
authors: YH
authors: Kim
authors: Hye Min
authors: HM
authors: Shim
authors: Young Kyung
authors: YK
authors: Bae
authors: Jung Hye
authors: JH
authors: Hwang
authors: Hosun
authors: H
authors: Park
mesh_terms: D000030:Abortion, Missed; D000818:Animals; D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein / Q000378:metabolism*; D003384:Coxsackievirus Infections / Q000821:virology*; D020964:Embryo Loss / Q000821:virology*; D004622:Embryo, Mammalian / Q000821:virology*; D029822:Enterovirus B, Human; D005260:Female; D005865:Gestational Age; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D013047:Specific Pathogen-Free Organisms; D014599:Uterus / Q000821:virology*
chemical_list: D062727:Coxsackie and Adenovirus Receptor-Like Membrane Protein