title: Variation in deep brain stimulation electrode impedance over years following electrode implantation.
abstract: BACKGROUND
  Deep brain stimulation (DBS) electrode impedance is a major determinant of current delivery to target tissues, but long-term variation in impedance has received little attention.
  
  
  OBJECTIVE
  To assess the relationship between electrode impedance and time in a large DBS patient population and characterize the relationship between contact activity and impedance.
  
  
  METHODS
  We collected retrospective impedance and programming data from 128 electrodes in 84 patients with Parkinson's disease, essential tremor or dystonia. Effects of time, contact activity, stimulation voltage and other parameters on impedance were assessed. We also examined impedance changes following contact activation and deactivation.
  
  
  RESULTS
  Impedance decreased by 73 Ω/year (p < 0.001), with 72% of contacts following a downward trend. Impedance was on average 163 Ω lower in active contacts (p < 0.001). Contact activation and inactivation were associated with a more (p < 0.001) and less (p = 0.016) rapid decline in impedance, respectively. Higher stimulation voltages were associated with lower impedance values (p < 0.001). Contact number and electrode model were also significant predictors of impedance.
  
  
  CONCLUSIONS
  Impedance decreases gradually in a stimulation-dependent manner. These trends have implications for long-term programming, the development of a closed-loop DBS device and current understanding of the electrode-tissue interface.
authors: Department of Neurosurgery, University of Minnesota, Minneapolis, Minn., USA.
authors: David
authors: D
authors: Satzer
authors: David
authors: D
authors: Lanctin
authors: Lynn E
authors: LE
authors: Eberly
authors: Aviva
authors: A
authors: Abosch
mesh_terms: D001921:Brain / Q000502:physiology* / Q000601:surgery; D046690:Deep Brain Stimulation / Q000295:instrumentation*; D017097:Electric Impedance; D004567:Electrodes, Implanted; D005500:Follow-Up Studies; D006801:Humans; D012189:Retrospective Studies