title: LDL cholesterol: should guidelines include targets?
abstract: Elevated low-density lipoprotein cholesterol (LDL-C) is associated with adverse cardiovascular outcomes. The strategy of target-based LDL-C lowering to reduce the risk of coronary heart disease and secondary event rates is now well established. However, the strategy for treating to a target LDL-C, and whether there is a lower threshold level for LDL-C continues to be debated. We present, and critically analyze the evidence for a target-based LDL-C lowering strategy, and the safety and efficacy of intensive plasma LDL-C-lowering with traditional, and novel LDL-lowering therapies below current guideline targets.
authors: Veterans Affairs North Texas Healthcare System, Dallas, TX, USA.
authors: Subhash
authors: S
authors: Banerjee
authors: Dhiman
authors: D
authors: Kahali
authors: Avantika
authors: A
authors: Banerjee
authors: Emmanouil S
authors: ES
authors: Brilakis
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D008078:Cholesterol, LDL / Q000097:blood*; D003327:Coronary Disease / Q000188:drug therapy*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D017410:Practice Guidelines as Topic
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL