title: The role of protein dynamics and thermal fluctuations in regulating cytochrome c/cytochrome c oxidase electron transfer.
abstract: In this overview we present recent combined electrochemical, spectroelectrochemical, spectroscopic and computational studies from our group on the electron transfer reactions of cytochrome c and of the primary electron acceptor of cytochrome c oxidase, the CuA site, in biomimetic complexes. Based on these results, we discuss how protein dynamics and thermal fluctuations may impact on protein ET reactions, comment on the possible physiological relevance of these results, and finally propose a regulatory mechanism that may operate in the Cyt/CcO electron transfer reaction in vivo. This article is part of a Special Issue entitled: 18th European Bioenergetic Conference.
authors: INQUIMAE-CONICET, Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, pab. 2, piso 3, C1428EHA Buenos Aires, Argentina.
authors: Damian
authors: D
authors: Alvarez-Paggi
authors: INQUIMAE-CONICET, Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, pab. 2, piso 3, C1428EHA Buenos Aires, Argentina.
authors: Ulises
authors: U
authors: Zitare
authors: INQUIMAE-CONICET, Departamento de Química Inorgánica, Analítica y Química Física, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, pab. 2, piso 3, C1428EHA Buenos Aires, Argentina. Electronic address: dhmurgida@qi.fcen.uba.ar.
authors: Daniel H
authors: DH
authors: Murgida
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D045304:Cytochromes c / Q000737:chemistry / Q000378:metabolism*; D004579:Electron Transport; D003576:Electron Transport Complex IV / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D062105:Molecular Docking Simulation; D056004:Molecular Dynamics Simulation; D008969:Molecular Sequence Data
chemical_list: D045304:Cytochromes c; D003576:Electron Transport Complex IV
keywords: Bioelectrochemistry; CuA; Cytochrome c; Electron transfer; Raman spectroelectrochemistry