title: [On-demand versus on-time dosing of tadalafil for erectile dysfunction: a prospective multi-center study].
abstract: OBJECTIVE
  To evaluate the safety and efficacy of tadalafil on demand and on time in men with erectile dysfunction.
  
  
  METHODS
  We conducted a multi-centered randomized controlled study on 120 ED males, who were assigned to take tadalafil at 10 mg/ 20 mg on demand before sexual activity and at the same dose on time twice a week for 8 weeks. Before and at 4 and 8 weeks after treatment, and 1 month after withdrawal, we obtained the scores on IIEF-5, ED Inventory of Treatment Satisfaction (EDITS) and the short form of Psychological and Interpersonal Relationship Scales (SF-PAIRS) , and compared the safety and efficacy of medication between the two groups of patients.
  
  
  RESULTS
  Totally, 110 patients accomplished the trial, 56 in the on-time and 54 in the on-demand group. At 4 and 8 weeks of medication and 1 month after withdrawal, the IIEF-5 scores were improved in both the on-time and on-demand groups, even more significantly in the former than in the latter at 8 weeks of treatment (21.6 +/- 2.9 vs 18.5 +/- 1.7) and 1 month after withdrawal (20.9 +/- 2.1 vs 17.9 +/- 2.3) (P < 0.05). The EDITS scores were significantly higher in the on-time than in the on-demand group at 8 weeks of treatment (31.7 +/- 6.9 vs 28.6 +/- 5.8) and 1 month after withdrawal (30.6 +/- 4.7 vs 27.9 +/- 6.5) (P < 0.05). The scores on the sexual self-confidence, spontaneity and time-concern domains of SF-PAIRS were remarkably improved after medication as compared with the baseline (P < 0.05), even more significantly in the on-time than in the on-demand group at 1 month after withdrawal. Both dosing schedules were well tolerated and no significant differences were observed in safety between the two groups.
  
  
  CONCLUSIONS
  On-time dosing of tadalafil is efficacious and well tolerated in the treatment of ED, and has an even better effect than on-demand dosing at 8 weeks of medication and 1 month after withdrawal.
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Jun-Long
authors: JL
authors: Wang
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Zhuan-Xin
authors: ZX
authors: Jiang
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Nian-Qin
authors: NQ
authors: Yang
authors: Department of Urology, Ruitjin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.
authors: Shan
authors: S
authors: Zhong
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Min
authors: M
authors: Wu
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Wei
authors: W
authors: Zhou
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Peng
authors: P
authors: Li
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Ru-Hui
authors: RH
authors: Tian
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Meng
authors: M
authors: Ma
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Yu-Fei
authors: YF
authors: Liu
authors: Department of Urology, Ruitjin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.
authors: Zhou-Jun
authors: ZJ
authors: Shen
authors: Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
authors: Guo-Min
authors: GM
authors: Wang
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Yi-Ran
authors: YR
authors: Huang
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Yi-Xin
authors: YX
authors: Wang
authors: Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China.
authors: Zheng
authors: Z
authors: Li
mesh_terms: D000328:Adult; D002243:Carbolines / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D011446:Prospective Studies; D000068581:Tadalafil; D016896:Treatment Outcome
chemical_list: D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D000068581:Tadalafil