title: High prevalence of vitamin D deficiency and insufficiency in patients with manifest Huntington disease: An explorative study.
abstract: Vitamin D deficiency and insufficiency are common in older institutionalized people and known to be associated with muscle weakness, impaired balance and increased fall risk. Falls and balance problems are common in people with Huntington disease (HD). Despite this, the prevalence of vitamin D deficiency in patients with manifest HD has never been investigated. Serum 25(OH)D levels were measured in routinely drawn blood samples from 28 Dutch institutionalized patients with manifest Huntington disease. Mean serum 25(OH)D level was 33 nmol/l (SD 15). Twenty-five subjects (89%) were vitamin D deficient or insufficient (25(OH)D &lt; 50 nmol/L). A positive association was found between serum 25(OH)D levels and Functional Ambulation Classification (FAC) scores (p = 0.023).
authors: Huntington Centre Topaz; Overduin; Katwijk, The Netherlands ; EMGO-institute; VU University Medical Center; Amsterdam, The Netherlands.
authors: Victor Gm
authors: VG
authors: Chel
authors: EMGO-institute; VU University Medical Center; Amsterdam, The Netherlands.
authors: Marcel E
authors: ME
authors: Ooms
authors: Huntington Centre Topaz; Overduin; Katwijk, The Netherlands.
authors: Jessie
authors: J
authors: van der Bent
authors: Huntington Centre Topaz; Overduin; Katwijk, The Netherlands.
authors: Fleur
authors: F
authors: Veldkamp
authors: Leiden University Medical Centre; Department of Neurology; Leiden, The Netherlands.
authors: Raymund Ac
authors: RA
authors: Roos
authors: Huntington Centre Topaz; Overduin; Katwijk, The Netherlands ; Leiden University Medical Centre; Department of Public Health and Primary Care; Leiden, The Netherlands.
authors: Wilco P
authors: WP
authors: Achterberg
authors: VU University Medical Center; Department of Internal Medicine/ Endocrinology; Amsterdam, The Netherlands.
authors: Paul
authors: P
authors: Lips
keywords: Huntington disease; fall risk; nursing home; vitamin D deficiency; vitamin D insufficiency