title: [Therapy of Inflammatory Bowel Disease].
abstract: Inflammatory Bowel Disease (i. e. Crohn's Disease and Ulcerative Colitis) show a rising incidence throughout Switzerland. An early and individualized therapy usually enables the effective treatment of both diseases and prevents structural gastrointestinal damage or surgical interventions. The goal of medical therapy is not only the relief of symptoms but rather the control of the disease's activity leading to mucosal healing and "deep" remission. Patients with unfavorable predictive parameters should receive a prompt intensification of medical therapy (as "early step-up" or even "top-down") with established immunosuppressive agents. Several updated practice guidelines respond to the most important medical questions, however, distinct clinical experience as well as a special dedication to these challenging patients are still a prerequisite for the effective and sustained therapy of inflammatory bowel disease.
authors: Klinik für Gastroenterologie und Hepatologie, Universitätsspital Basel.
authors: Ingo
authors: I
authors: Mecklenburg
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000465:Algorithms; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003424:Crohn Disease / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D015507:Drugs, Investigational / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D015507:Drugs, Investigational; D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha
keywords: Colitis ulcerosa; Crohn's Disease; Inflammatory Bowel Disease; Morbus Crohn; Ulcerative Colitis; chronisch-entzündliche Darmerkrankungen; colite ulcéreuse; maladie de Crohn; maladie inflammatoire du système digestif; medikamentöse Therapie; pharmacotherapy; pharmacothérapie