title: Two- and three-dimensional speckle tracking analysis of the relation between myocardial deformation and functional capacity in patients with systemic hypertension.
abstract: The purpose of this study was to investigate left ventricular (LV) mechanics in hypertensive patients by 2- and 3-dimensional (3D) speckle tracking imaging, and determine the relation between the LV mechanics and functional capacity in this population. This cross-sectional study included 51 recently diagnosed, untreated, hypertensive patients, 49 treated subjects with well-controlled arterial hypertension, 52 treated participants with uncontrolled hypertension, and 50 controls adjusted by gender and age. All the subjects underwent 24-hour blood pressure monitoring, complete 2-dimensional and 3D examination, and cardiopulmonary exercise testing. 3D global longitudinal, circumferential, radial, and area strains were similar between the control group and well-controlled hypertensive patients but significantly decreased in comparison with patients with untreated or inadequately controlled hypertension. Similar findings were obtained for LV torsion and twist rate, whereas LV untwisting rate significantly deteriorated from the controls, across the well-controlled group, to the patients with untreated or uncontrolled hypertension. Peak oxygen uptake was significantly lower in the patients with untreated and uncontrolled hypertension than in the controls and the well-treated hypertensive patients. Peak oxygen uptake was independently associated with LV untwisting rate (β = 0.28, p = 0.03), 3D LV ejection fraction (β = 0.31, p = 0.024), and 3D global longitudinal strain (β = 0.26, p = 0.037) in the whole hypertensive population in our study. In conclusion, LV mechanics and functional capacity are significantly impaired in the patients with uncontrolled and untreated hypertension in comparison with the controls and the well-controlled hypertensive patients. Functional capacity is independently associated with 3D global longitudinal strain, LV untwisting rate, and 3D LV ejection fraction.
authors: Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic," Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Vera
authors: V
authors: Celic
authors: Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic," Belgrade, Serbia. Electronic address: marijana_tadic@hotmail.com.
authors: Marijana
authors: M
authors: Tadic
authors: Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic," Belgrade, Serbia.
authors: Jelena
authors: J
authors: Suzic-Lazic
authors: Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic," Belgrade, Serbia.
authors: Anita
authors: A
authors: Andric
authors: Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic," Belgrade, Serbia.
authors: Anka
authors: A
authors: Majstorovic
authors: Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Cardiology Department, Clinical Centre of Serbia, Clinic of Cardiology, Belgrade, Serbia.
authors: Branislava
authors: B
authors: Ivanovic
authors: Anesthesiology Department, University Clinical Hospital Center "Dr Dragisa Misovic," Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Predrag
authors: P
authors: Stevanovic
authors: Cardiology Department, University Clinical Hospital Center "Dr Dragisa Misovic," Belgrade, Serbia.
authors: Olinka
authors: O
authors: Iracek
authors: General Surgery Department, University Clinical Hospital Center "Dr Dragisa Misovic," Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Radisav
authors: R
authors: Scepanovic
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D015150:Echocardiography, Doppler / Q000379:methods*; D019560:Echocardiography, Three-Dimensional / Q000379:methods; D005080:Exercise Test; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D013318:Stroke Volume / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology*