title: Association between -1562C>T polymorphism in the promoter region of matrix metalloproteinase-9 and coronary artery disease: a meta-analysis.
abstract: OBJECTIVE
  The present study was undertaken to determine the association between -1562C>T polymorphism in the promoter region of matrix metalloproteinase-9 (MMP-9) and coronary artery disease (CAD) risk.
  
  
  METHODS
  This meta-analysis was on the basis of 26 studies that included 12,776 cases and 6371 controls, heterogeneity of which was assessed by the Q-statistic test and the I(2)-statistic test. Sensitivity analysis was conducted by sequentially omitting any single study and recalculating the odds ratios (ORs) and 95% confidence intervals (CIs). Funnel plots and Egger's test were performed to test the potential publication bias. All data were analyzed by using STATA version 12.0.
  
  
  RESULTS
  We found that -1562C>T polymorphism did not contribute to the risk of CAD in the overall results. But the stratified analysis by ethnicity indicated that -1562C>T polymorphism might decrease susceptibility to CAD in Asians (OR, 0.94; 95% CI, 0.88-1.00; ph=0.956 for CC vs. CT+TT).
  
  
  CONCLUSIONS
  Our meta-analysis supports the fact that -1562C>T polymorphism may have association with CAD risk in Asian populations. But further larger studies are required to confirm our findings.
authors: Department of Cardiovascular Surgery, The First Hospital of Liaoning Medical University , Jinzhou, China .
authors: Feng-Xiang
authors: FX
authors: Zhang
authors: Da-Peng
authors: DP
authors: Sun
authors: Ning
authors: N
authors: Guan
authors: Jun-Jiang
authors: JJ
authors: Chen
authors: Xiao-Chuan
authors: XC
authors: Huo
authors: Jun-Sheng
authors: JS
authors: Luo
mesh_terms: D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics*; D056726:Genetic Association Studies / Q000706:statistics & numerical data; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease / Q000208:ethnology; D005838:Genotype; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data
chemical_list: C579270:MMP9 protein, human; D020780:Matrix Metalloproteinase 9