title: Photoacoustic thermography of tissue.
abstract: Photoacoustic (PA) techniques can measure temperature in biological tissues because PA signal amplitude is sensitive to tissue temperature. So far, temperature-measuring PA techniques have focused on sensing of temperature changes at a single position. In this work, we photoacoustically measured spatial distribution of temperature in deep tissue. By monitoring the temperature at a single position using a thermocouple, the relationship between the PA signal amplitude and the actual temperature was determined. The relationship was then used to translate a PA image into a temperature map. This study showed that it is possible to calibrate the system for the temperature range of hyperthermia using single-point measurements over a smaller temperature range. Our experimental results showed a precision of -0.8±0.4°C (mean±standard error) in temperature measurement, and a spatial resolution as fine as 1.0 mm. PA techniques can be potentially applied to monitor temperature distribution deep in tissue during hyperthermia treatment of cancer.
authors: Haixin
authors: H
authors: Ke
authors: Stephen
authors: S
authors: Tai
authors: Lihong V
authors: LV
authors: Wang
mesh_terms: D000818:Animals; D002138:Calibration; D002645:Chickens; D006979:Hyperthermia, Induced; D018482:Muscle, Skeletal / Q000502:physiology; D019047:Phantoms, Imaging; D061088:Photoacoustic Techniques / Q000379:methods*; D015203:Reproducibility of Results; D013696:Temperature; D013817:Thermography / Q000379:methods*