title: Application of imaging based tools for the characterisation of hollow spray dried amorphous dispersion particles.
abstract: The aim of this study was to investigate novel approaches to determine spray dried dispersion (SDD) specific particle characteristics through the use of imaging based technologies. The work demonstrates approaches that can be applied in order to access quantitative approximations for powder characteristics for hollow particles, such as SDD. Cryo-SEM has been used to measure the solid volume fraction and/or particle density of SDD particles. Application of this data to understand the impact of spray drying process conditions on SDD powder properties, and their impact on processability and final dosage form quality were investigated. The use of data from a Morphologi G3 image based particle characterisation system was also examined in order to explain both the propensity and extent of attrition within a series of SDD samples, and also demonstrate the use of light transmission data to assess the relative wall thickness of SDD particles. Such approaches demonstrate a means to access potentially useful information that can be linked to important particle characteristics for SDD materials which, in addition to the standard bulk powder measurements such as bulk density, may enable a better understanding of such materials and their impact on downstream processability and final dosage form acceptability.
authors: Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral CH46 1QW, UK. Electronic address: john.gamble@bms.com.
authors: John F
authors: JF
authors: Gamble
authors: Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral CH46 1QW, UK.
authors: Ana P
authors: AP
authors: Ferreira
authors: Bristol-Myers Squibb, Reeds Lane, Moreton, Wirral CH46 1QW, UK.
authors: Mike
authors: M
authors: Tobyn
authors: Bristol-Myers Squibb, New Brunswick, NJ, USA.
authors: Lynn
authors: L
authors: DiMemmo
authors: Bristol-Myers Squibb, New Brunswick, NJ, USA.
authors: Kyle
authors: K
authors: Martin
authors: Bristol-Myers Squibb, New Brunswick, NJ, USA.
authors: Neil
authors: N
authors: Mathias
authors: Bristol-Myers Squibb, New Brunswick, NJ, USA.
authors: Richard
authors: R
authors: Schild
authors: Bristol-Myers Squibb, New Brunswick, NJ, USA.
authors: Balvinder
authors: B
authors: Vig
authors: Bend Research, Bend, OR, USA.
authors: John M
authors: JM
authors: Baumann
authors: Bend Research, Bend, OR, USA.
authors: Stacy
authors: S
authors: Parks
authors: Intertek Pharmaceutical Services Manchester, M9 8ZS, UK.
authors: Mike
authors: M
authors: Ashton
mesh_terms: D002626:Chemistry, Pharmaceutical; D020285:Cryoelectron Microscopy; D003890:Desiccation; D008027:Light; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011208:Powders; D012542:Scattering, Radiation; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations; D011208:Powders
keywords: Density; Imaging; Pharmaceuticals; Powder properties; Spray dried dispersion; Spray drying