title: Successful maternal and fetal outcome in a kidney transplant patient with everolimus exposure throughout pregnancy: a case report.
abstract: Pregnancy after kidney transplantation is becoming more common as more patients of childbearing age are undergoing successful transplantation. There is limited evidence on the safety and efficacy of mammalian target of rapamycin inhibitors during pregnancy, which are considered Category C. We will review the use of this class of medications in pregnancy, which is currently contraindicated due to risk of fetal complications. We will also present the case of a successful pregnancy and renal outcome in a 33-year-old kidney transplant recipient who was administered everolimus throughout pregnancy.
authors: Department of Nephrology, Washington Hospital Center, Washington, DC. Electronic address: hannahma@pcom.edu.
authors: H R
authors: HR
authors: Margoles
authors: Department of OB/GYN, Georgetown University Hospital, Washington, DC.
authors: V
authors: V
authors: Gomez-Lobo
authors: Department of Nephrology, Washington Hospital Center, Washington, DC.
authors: J H
authors: JH
authors: Veis
authors: Department of Nephrology, Washington Hospital Center, Washington, DC.
authors: M J
authors: MJ
authors: Sherman
authors: Georgetown University Transplant Institute, Washington, DC.
authors: J
authors: J
authors: Moore
mesh_terms: D000328:Adult; D000068338:Everolimus; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D018811:Maternal Exposure; D061214:Patient Safety; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012306:Risk; D020123:Sirolimus / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D000068338:Everolimus; D020123:Sirolimus