title: [The influence of sodium hyaluronate solution and artificial tears on higher-order aberrations].
abstract: OBJECTIVE
  To investigate the influence of sodium hyaluronate solution (HA) and artificial tears (AT) on higher-order aberrations (HOAs).
  
  
  METHODS
  Twenty four eyes of 24 normal subjects and 11 eyes of 11 dry eye patients were examined. Cornea and ocular wavefront aberrations (total, spherical-like and coma-like) were measured with a Hartmann-Shack wavefront aberrometer before and after 0.1% or 0.3% HA, AT. The consecutively obtained data of the cornea and ocular HOAs were analyzed in the central 4-mm diameter for coma-like, spherical-like and total HOAs. Average HOAs, as well as fluctuation index (FI) and stability index (SI) of the HOAs over time were compared between the two groups.
  
  
  RESULTS
  In normal subjects, the AVE of all aberration parameters and FI showed an increase depending on viscosity of the HA (p < 0.001). After AT and 0.1% HA treatment the cornea aberration of the dry eye patients changed from a sawtooth pattern to a stable pattern.
  
  
  CONCLUSIONS
  Cornea HOAs decreased, and the optical characteristics showed improvement after AT and 0.1% HA in the dry eye patients. HOAs increased depending on the viscosity of the HA, and optical stability worsened.
authors: Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Japan. tsutomu-y@mw.kawasaki-m.ac.jp
authors: Tsutomu
authors: T
authors: Yamashita
authors: Inoue Eye Clinic.
authors: Shintarou
authors: S
authors: Ochi
authors: Inoue Eye Clinic.
authors: Yasushi
authors: Y
authors: Inoue
authors: Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Japan.
authors: Atsushi
authors: A
authors: Miki
authors: Department of Ophthalmology, Kawasaki Medical School.
authors: Junichi
authors: J
authors: Kiryu
authors: Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Japan.
authors: Akio
authors: A
authors: Tabuchi
mesh_terms: D000328:Adult; D015352:Dry Eye Syndromes / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology*; D008297:Male; D009883:Ophthalmic Solutions / Q000494:pharmacology*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
chemical_list: D009883:Ophthalmic Solutions; D006820:Hyaluronic Acid