title: Frontal tDCS modulates orbitofrontal reality filtering.
abstract: Orbitofrontal reality filtering denotes a memory control mechanism necessary to keep thought and behavior in phase with reality. Its failure induces reality confusion as evident in confabulation and disorientation. In the present study, we explored the influence of orbitofrontal transcranial direct current stimulation (tDCS) on reality filtering. Twenty healthy human subjects made a reality filtering task, while receiving cathodal, anodal, or sham stimulation over the frontal pole in three sessions separated by at least 1week. Computational models predicted that this montage can produce polarity-specific current flow across the posterior medial orbitofrontal cortex (OFC). In agreement with our hypothesis, we found that cathodal tDCS over the frontal pole specifically impaired reality filtering in comparison to anodal and sham stimulation. This study shows that reality filtering, an orbitofrontal function, can be modulated with tDCS.
authors: Laboratory of Cognitive Neurorehabilitation, Department of Clinical Neurosciences, University of Geneva, Switzerland. Electronic address: aurelie.manuelstocker@hcuge.ch.
authors: A L
authors: AL
authors: Manuel
authors: Neural Engineering Laboratory, Department of Biomedical Engineering, The City College of New York of the City University of New York, NY, USA.
authors: A W
authors: AW
authors: David
authors: Neural Engineering Laboratory, Department of Biomedical Engineering, The City College of New York of the City University of New York, NY, USA.
authors: M
authors: M
authors: Bikson
authors: Laboratory of Cognitive Neurorehabilitation, Department of Clinical Neurosciences, University of Geneva, Switzerland; Division of Neurorehabilitation, Department of Clinical Neurosciences, University Hospital of Geneva, Switzerland.
authors: A
authors: A
authors: Schnider
mesh_terms: D000293:Adolescent; D000328:Adult; D004558:Electric Stimulation; D005260:Female; D005625:Frontal Lobe / Q000502:physiology; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D021641:Recognition, Psychology / Q000502:physiology*; D055815:Young Adult
keywords: confabulations; continuous recognition task; extinction; orbitofrontal cortex; tDCS