title: The Role of Immunogenicity in Cardiovascular Disease.
abstract: Recently, many of the complexities associated with cardiovascular diseases (CVD) have been unlocked. However, despite these breakthroughs, CVD and its related complications are the leading contributors of morbidity and mortality worldwide, which indicates the shortcomings of current treatment regimens and the need for continued research. Published data within the field clearly indicates that CVD are built on inflammation and autoimmune platforms, though a strong, fundamental understanding of the mechanisms remains elusive. Areas such as the mechanisms underlying increased immunogenicity of self-proteins in the cardiovascular system, the roles of immunogenic auto-antigens in eliciting inflammatory autoimmune responses, and the immunosuppressive mechanisms involved in controlling inflammatory and autoimmune cardiovascular diseases remain to be well-understood. We will delve into these topics and the advancements made within the field in this review. Specifically, we will concentrate on the innate and adaptive immune responses mediating immunogenicity; the mechanisms of inflammation and autoimmunity in atherogenesis; the mechanisms of inflammation and autoimmunity in diabetic atherosclerosis; immunogenicity and stem cell therapy; as well as immunogenicity and immunosuppression. In depth examination and comprehension of these topics will provide insight into the recent progress of the field and bring to the forefront potentially novel therapeutic avenues.
authors: Department of Pharmacology ; Independence Blue Cross Cardiovascular Research Center ; Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140.
authors: Michael
authors: M
authors: Jan
authors: Department of Pharmacology ; Independence Blue Cross Cardiovascular Research Center.
authors: Anthony T
authors: AT
authors: Virtue
authors: Department of Pharmacology ; Independence Blue Cross Cardiovascular Research Center.
authors: Meghanaben
authors: M
authors: Pansuria
authors: Department of Pharmacology ; Independence Blue Cross Cardiovascular Research Center.
authors: Jingshan
authors: J
authors: Liu
authors: Department of Pharmacology ; Independence Blue Cross Cardiovascular Research Center.
authors: Xinyu
authors: X
authors: Xiong
authors: Department of Pharmacology ; Independence Blue Cross Cardiovascular Research Center.
authors: Pu
authors: P
authors: Fang
authors: Department of Pharmacology ; Independence Blue Cross Cardiovascular Research Center.
authors: Shu
authors: S
authors: Meng
authors: Department of Pharmacology ; Independence Blue Cross Cardiovascular Research Center ; Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA 19140.
authors: Hong
authors: H
authors: Wang
authors: Department of Pharmacology ; Independence Blue Cross Cardiovascular Research Center.
authors: Xiao-Feng
authors: XF
authors: Yang
keywords: atherosclerosis; autoimmunity; diabetes; immunogenicity; immunosuppression; inflammation; stem cell therapy