title: Ondansetron preloading with crystalloid infusion reduces maternal hypotension during cesarean delivery.
abstract: OBJECTIVE
  The aim of the article was to investigate the effect of ondansetron preloading with crystalloid infusion after spinal anesthesia during cesarean delivery.
  
  
  METHODS
  A total of 66 parturient women scheduled for elective caesarean sections were randomly assigned to two groups. Five minutes before spinal anesthesia, Group O patients were injected with 4 mg of ondansetron, while Group S patients were injected with 5 mL physiological saline. Maternal blood pressure and heart rate were measured at 2 minute intervals for 30 minutes. After delivery, umbilical cord blood samples were analyzed.
  
  
  RESULTS
  Maternal hypotension and nausea were significantly lower in ondansetron-treated patients versus placebo (p = 0.011 vs. 0.004). Umbilical venous pH was significantly higher in ondansetron-treated patients (p = 0.006), while partial pressure of carbon dioxide (Pco 2) was significantly lower (p = 0.002). Decreases in maternal systolic and mean arterial blood pressures were significantly lower in ondansetron-treated patients (p = 0.008 vs. 0.025), with less requirement for phenylephrine administration compared with controls (p = 0.029).
  
  
  CONCLUSIONS
  Ondansetron preloading combined with crystalloid infusion significantly reduced hypotension and nausea, while improving acid-base status, as well as reducing vasoconstrictor use.
authors: Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.
authors: Qun
authors: Q
authors: Wang
authors: School of Public Health, Xuzhou Medical College, Xuzhou, China.
authors: Lang
authors: L
authors: Zhuo
authors: Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.
authors: Ming-Kun
authors: MK
authors: Shen
authors: Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.
authors: Yan-Yun
authors: YY
authors: Yu
authors: Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.
authors: Jun-Jing
authors: JJ
authors: Yu
authors: Department of Anesthesiology, Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Wuxi, China.
authors: Meng
authors: M
authors: Wang
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide; D002585:Cesarean Section; D000077324:Crystalloid Solutions; D017558:Elective Surgical Procedures; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007022:Hypotension / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D007552:Isotonic Solutions / Q000008:administration & dosage*; D009325:Nausea / Q000517:prevention & control; D017294:Ondansetron / Q000008:administration & dosage*; D010313:Partial Pressure; D010656:Phenylephrine / Q000627:therapeutic use; D011247:Pregnancy; D011300:Preoperative Care; D014662:Vasoconstrictor Agents / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D014151:Anti-Anxiety Agents; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D014662:Vasoconstrictor Agents; D002245:Carbon Dioxide; D010656:Phenylephrine; D017294:Ondansetron