title: Oxidant-free conversion of cyclic amines to lactams and H2 using water as the oxygen atom source.
abstract: Direct conversion of cyclic amines to lactams utilizing water as the only reagent is catalyzed by pincer complex 2. In contrast to previously known methods of amine-to-amide conversion, this reaction occurs in the absence of oxidants and is accompanied by liberation of H2, with water serving as a source of oxygen atom. Formation of a cyclic hemiaminal intermediate plays a key role in enabling such reactivity. This represents an unprecedented, conceptually new type of amide formation reaction directly from amines and water under oxidant-free conditions.
authors: Department of Organic Chemistry, Weizmann Institute of Science , Rehovot, 76100, Israel.
authors: Julia R
authors: JR
authors: Khusnutdinova
authors: Yehoshoa
authors: Y
authors: Ben-David
authors: David
authors: D
authors: Milstein
mesh_terms: D000166:Acridines / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D007769:Lactams / Q000138:chemical synthesis*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000166:Acridines; D000588:Amines; D007769:Lactams; D009942:Organometallic Compounds; D012428:Ruthenium