title: The effect of molecular subtype and body mass index on neo-adjuvant chemotherapy in breast cancer patients.
abstract: The aim of the present study was to analyze the effect of subtype and body mass index (BMI) on neo-adjuvant chemotherapy (NAC) and postoperative prognosis. Two-hundred and forty nine patients who underwent surgery after NAC were included. A multivariate analysis and survival analysis were used to clarify the relationship between BMI, subtype, and NAC. In the logistic regression model, the pCR rate had a significant relationship with the subtype and tumor stage. In the non-pCR group, more overweight patients had significantly a worse disease-free survival (DFS) compared to normal range patients (Log lank test, p < 0.05). In the Cox proportional hazards model, subtype and tumor stage were significantly associated with decreased DFS. In conclusion, patients with the ER (+), HER (-) type and a high BMI had a high risk for recurrence when they achieved non-pCR after NAC.
authors: Division of Breast Surgery, Chiba Cancer Center Hospital, 666-2, Nitona-Cho, Chuo-Ku, Chiba, Japan.
authors: Toshiaki
authors: T
authors: Iwase
authors: Division of Breast Surgery, Chiba Cancer Center Hospital, 666-2, Nitona-Cho, Chuo-Ku, Chiba, Japan. Electronic address: rikiya@graduate.chiba-u.jp.
authors: Rikiya
authors: R
authors: Nakamura
authors: Division of Breast Surgery, Chiba Cancer Center Hospital, 666-2, Nitona-Cho, Chuo-Ku, Chiba, Japan.
authors: Naohito
authors: N
authors: Yamamoto
authors: Division of Breast Surgery, Chiba Cancer Center Hospital, 666-2, Nitona-Cho, Chuo-Ku, Chiba, Japan.
authors: Atushi
authors: A
authors: Yoshi
authors: Division of Diagnostic Pathology, Chiba Cancer Center Hospital, Chiba, Japan.
authors: Makiko
authors: M
authors: Itami
authors: Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
authors: Masaru
authors: M
authors: Miyazaki
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000145:classification / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008408:Mastectomy / Q000706:statistics & numerical data; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology; D009367:Neoplasm Staging; D009765:Obesity / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D011956:Receptors, Cell Surface / Q000032:analysis; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D011956:Receptors, Cell Surface
keywords: Body mass index; Breast neoplasms; Neoadjuvant therapy