title: Pd/C as a catalyst for completely regioselective C-H functionalization of thiophenes under mild conditions.
abstract: The completely C3-selective arylation of thiophenes and benzo[b]thiophenes was achieved by using Pd/C as a heterogeneous catalyst without ligands or additives under mild reaction conditions. The practicability of this transformation is demonstrated by notable functional group tolerance and the insensitivity of the reaction to H2 O and air. This method is also applicable to nitrogen- and oxygen-containing heterocycles, yielding the corresponding C2-arylated products. Three-phase tests along with Hg-poisoning and hot-filtration tests suggest that the catalytically active species is heterogeneous in nature.
authors: Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany) http://www.uni-muenster.de/Chemie.oc/glorius/index.html.
authors: Dan-Tam D
authors: DT
authors: Tang
authors: Karl D
authors: KD
authors: Collins
authors: Johannes B
authors: JB
authors: Ernst
authors: Frank
authors: F
authors: Glorius
keywords: C-H functionalization; Pd/C; heterogeneous catalysis; hypervalent iodine compounds; thiophenes