title: Enantioselective palladium-catalyzed insertion of α-aryl-α-diazoacetates into the O-H bonds of phenols.
abstract: A palladium-catalyzed asymmetric O-H insertion reaction was developed. Palladium complexes with chiral spiro bisoxazoline ligands promoted the insertion of α-aryl-α-diazoacetates into the O-H bond of phenols with high yield and excellent enantioselectivity under mild reaction conditions. This palladium-catalyzed asymmetric O-H insertion reaction provided an efficient and highly enantioselective method for the preparation of synthetically useful optically active α-aryl-α-aryloxyacetates.
authors: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin).
authors: Xiu-Lan
authors: XL
authors: Xie
authors: Shou-Fei
authors: SF
authors: Zhu
authors: Jun-Xia
authors: JX
authors: Guo
authors: Yan
authors: Y
authors: Cai
authors: Qi-Lin
authors: QL
authors: Zhou
keywords: asymmetric catalysis; bisoxazoline ligands; carbenes; palladium; α-aryl-α-aryloxyacetates