title: Design and syntheses of peptides which induce or enhance structural changes of recombinant bovine prion protein (rbPrP) and discovery of peptides from bovine brain which accelerate structural conversions of rbPrP.
abstract: The co-existence of certain peptides influenced the kinetic rate of aggregation and the lag-time of fibril formation of rbPrP. Using recently developed structural conversion assay system, peptides have been screened from bovine brain peptide library. Peptide sequences of positive components have been elucidated by mass spectrometry and chemically synthesized to confirm actions.
authors: Kiyoshi
authors: K
authors: Nokihara
authors: Shunsuke
authors: S
authors: Yajima
authors: Akiyoshi
authors: A
authors: Hirata
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002417:Cattle; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D011328:Prions / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D010455:Peptides; D011328:Prions; D011994:Recombinant Proteins