title: Induction of innate immune response following infectious bronchitis corona virus infection in the respiratory tract of chickens.
abstract: Infectious bronchitis virus (IBV) replicates in the epithelial cells of trachea and lungs of chicken, however the mechanism of generation of innate immune response against IBV infection in these tissues has not been fully characterized. Our objective was to study innate responses induced early following IBV infection in chickens. Initiation of the transcription of selected innate immune genes such as TLR3, TLR7, MyD88, IL-1β and IFN-β, as well as recruitment of macrophages, were evident following an initial down regulation of some of the observed genes (TLR3, IL-1β, and IFN-γ) in trachea and lung. This initial down-regulation followed by the induction of innate immune response to IBV infection appears to be inadequate for the control of IBV genome accumulation and consequent histopathological changes in these tissues. Potential induction of innate immunity before infection occurs may be necessary to reduce the consequences since vaccine induced immunity is slow to develop.
authors: Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada AB T2N 2Z6.
authors: Amber Marie
authors: AM
authors: Kameka
authors: Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada AB T2N 2Z6.
authors: Siamak
authors: S
authors: Haddadi
authors: Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada AB T2N 2Z6.
authors: Dae Sun
authors: DS
authors: Kim
authors: Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada AB T2N 2Z6.
authors: Susan Catherine
authors: SC
authors: Cork
authors: Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada AB T2N 2Z6. Electronic address: faizal.abdulcareem@ucalgary.ca.
authors: Mohammad Faizal
authors: MF
authors: Abdul-Careem
mesh_terms: D000818:Animals; D030161:Avian Proteins / Q000235:genetics / Q000276:immunology; D002645:Chickens; D018352:Coronavirus Infections / Q000235:genetics / Q000276:immunology / Q000662:veterinary* / Q000821:virology; D007113:Immunity, Innate; D001351:Infectious bronchitis virus / Q000276:immunology / Q000502:physiology*; D011201:Poultry Diseases / Q000235:genetics / Q000276:immunology* / Q000821:virology; D012137:Respiratory System / Q000276:immunology* / Q000821:virology; D051196:Toll-Like Receptor 3 / Q000235:genetics / Q000276:immunology; D051199:Toll-Like Receptor 7 / Q000235:genetics / Q000276:immunology
chemical_list: D030161:Avian Proteins; D051196:Toll-Like Receptor 3; D051199:Toll-Like Receptor 7
keywords: Avian; Cytokine; Infectious bronchitis virus; Macrophage; Toll-like receptor