title: Collaborative approach in the development of high-performance brain-computer interfaces for a neuroprosthetic arm: translation from animal models to human control.
abstract: Our research group recently demonstrated that a person with tetraplegia could use a brain-computer interface (BCI) to control a sophisticated anthropomorphic robotic arm with skill and speed approaching that of an able-bodied person. This multiyear study exemplifies important principles in translating research from foundational theory and animal experiments into a clinical study. We present a roadmap that may serve as an example for other areas of clinical device research as well as an update on study results. Prior to conducting a multiyear clinical trial, years of animal research preceded BCI testing in an epilepsy monitoring unit, and then in a short-term (28 days) clinical investigation. Scientists and engineers developed the necessary robotic and surgical hardware, software environment, data analysis techniques, and training paradigms. Coordination among researchers, funding institutes, and regulatory bodies ensured that the study would provide valuable scientific information in a safe environment for the study participant. Finally, clinicians from neurosurgery, anesthesiology, physiatry, psychology, and occupational therapy all worked in a multidisciplinary team along with the other researchers to conduct a multiyear BCI clinical study. This teamwork and coordination can be used as a model for others attempting to translate basic science into real-world clinical situations.
authors: Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA; Department of Physical Medicine & Rehabilitation; Department of Bioengineering.
authors: Jennifer L
authors: JL
authors: Collinger
authors: Michael A
authors: MA
authors: Kryger
authors: Richard
authors: R
authors: Barbara
authors: Timothy
authors: T
authors: Betler
authors: Kristen
authors: K
authors: Bowsher
authors: Elke H P
authors: EH
authors: Brown
authors: Samuel T
authors: ST
authors: Clanton
authors: Alan D
authors: AD
authors: Degenhart
authors: Stephen T
authors: ST
authors: Foldes
authors: Robert A
authors: RA
authors: Gaunt
authors: Ferenc E
authors: FE
authors: Gyulai
authors: Elizabeth A
authors: EA
authors: Harchick
authors: Deborah
authors: D
authors: Harrington
authors: John B
authors: JB
authors: Helder
authors: Timothy
authors: T
authors: Hemmes
authors: Matthew S
authors: MS
authors: Johannes
authors: Kapil D
authors: KD
authors: Katyal
authors: Geoffrey S F
authors: GS
authors: Ling
authors: Angus J C
authors: AJ
authors: McMorland
authors: Karina
authors: K
authors: Palko
authors: Matthew P
authors: MP
authors: Para
authors: Janet
authors: J
authors: Scheuermann
authors: Andrew B
authors: AB
authors: Schwartz
authors: Elizabeth R
authors: ER
authors: Skidmore
authors: Florian
authors: F
authors: Solzbacher
authors: Anita V
authors: AV
authors: Srikameswaran
authors: Dennis P
authors: DP
authors: Swanson
authors: Scott
authors: S
authors: Swetz
authors: Elizabeth C
authors: EC
authors: Tyler-Kabara
authors: Meel
authors: M
authors: Velliste
authors: Wei
authors: W
authors: Wang
authors: Douglas J
authors: DJ
authors: Weber
authors: Brian
authors: B
authors: Wodlinger
authors: Michael L
authors: ML
authors: Boninger
mesh_terms: D000328:Adult; D000818:Animals; D001186:Artificial Limbs / Q000706:statistics & numerical data; D062207:Brain-Computer Interfaces / Q000706:statistics & numerical data; D003299:Cooperative Behavior; D004569:Electroencephalography; D006801:Humans; D008297:Male; D023421:Models, Animal; D011323:Primates; D011474:Prosthesis Design; D011782:Quadriplegia / Q000534:rehabilitation; D012371:Robotics / Q000295:instrumentation / Q000706:statistics & numerical data; D012984:Software; D013119:Spinal Cord Injuries / Q000534:rehabilitation; D057170:Translational Research, Biomedical; D014584:User-Computer Interface
keywords: brain; clinical trials; methodology; translational research