title: A temporal basis for predicting the sensory consequences of motor commands in an electric fish.
abstract: Mormyrid electric fish are a model system for understanding how neural circuits predict the sensory consequences of motor acts. Medium ganglion cells in the electrosensory lobe create negative images that predict sensory input resulting from the fish's electric organ discharge (EOD). Previous studies have shown that negative images can be created through plasticity at granule cell-medium ganglion cell synapses, provided that granule cell responses to the brief EOD command are sufficiently varied and prolonged. Here we show that granule cells indeed provide such a temporal basis and that it is well-matched to the temporal structure of self-generated sensory inputs, allowing rapid and accurate sensory cancellation and explaining paradoxical features of negative images. We also demonstrate an unexpected and critical role of unipolar brush cells (UBCs) in generating the required delayed responses. These results provide a mechanistic account of how copies of motor commands are transformed into sensory predictions.
authors: Department of Neuroscience, Columbia University, New York, New York, USA.
authors: Ann
authors: A
authors: Kennedy
authors: 1] Department of Neuroscience, Columbia University, New York, New York, USA. [2].
authors: Greg
authors: G
authors: Wayne
authors: 1] Department of Neuroscience, Columbia University, New York, New York, USA. [2].
authors: Patrick
authors: P
authors: Kaifosh
authors: Department of Neuroscience, Columbia University, New York, New York, USA.
authors: Karina
authors: K
authors: Alviña
authors: 1] Department of Neuroscience, Columbia University, New York, New York, USA. [2] Department of Physiology and Cellular Biophysics, Columbia University, New York, New York, USA.
authors: L F
authors: LF
authors: Abbott
authors: Department of Neuroscience, Columbia University, New York, New York, USA.
authors: Nathaniel B
authors: NB
authors: Sawtell
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology; D004555:Electric Fish / Q000502:physiology*; D004557:Electric Organ / Q000502:physiology*; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D008839:Microelectrodes; D009474:Neurons / Q000502:physiology*; D012677:Sensation / Q000502:physiology*; D013997:Time Factors