title: Palladium-catalyzed synthesis of benzofurans via C-H activation/oxidation tandem reaction and its application to the synthesis of decursivine and serotobenine.
abstract: A new palladium-catalyzed method for the synthesis of benzofurans by reaction of 2-hydroxystyrenes and iodobenzenes via a C-H activation/oxidation tandem reaction has been unprecedentedly discovered. By using this strategy, the overall synthetic efficiency of the synthesis of decursivine and its analogues was indeed improved. Preliminary mechanistic studies shed light into the possible mechanisms.
authors: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China. yxjia@bjmu.edu.cn.
authors: Lei
authors: L
authors: Guo
authors: Fengying
authors: F
authors: Zhang
authors: Weimin
authors: W
authors: Hu
authors: Lei
authors: L
authors: Li
authors: Yanxing
authors: Y
authors: Jia
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D026121:Indole Alkaloids / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D026121:Indole Alkaloids; D007211:Indoles; C560343:decursivine; C531376:serotobenine; D010165:Palladium; D002244:Carbon; D006859:Hydrogen