title: A mild and selective Pd-mediated methodology for the synthesis of highly fluorescent 2-arylated tryptophans and tryptophan-containing peptides: a catalytic role for Pd(0) nanoparticles?
abstract: A Pd-mediated direct C-H bond functionalisation of tryptophan has been developed, both as a single amino acid residue and within peptides. Important mechanistic insight into this process has been gained by characterising a Pd catalytically competent nanoparticle phase which evolves during the early stages of reaction.
authors: Department of Chemistry, University of York, York, UK YO10 5DD. ian.fairlamb@york.ac.uk.
authors: Thomas J
authors: TJ
authors: Williams
authors: Alan J
authors: AJ
authors: Reay
authors: Adrian C
authors: AC
authors: Whitwood
authors: Ian J S
authors: IJ
authors: Fairlamb
mesh_terms: D002384:Catalysis; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D014364:Tryptophan / Q000031:analogs & derivatives / Q000138:chemical synthesis*
chemical_list: D005456:Fluorescent Dyes; D010455:Peptides; D010165:Palladium; D014364:Tryptophan