title: Exposure to polybrominated diphenyl ethers and male reproductive function in Greenland, Poland and Ukraine.
abstract: Animal and a few human studies suggest that polybrominated diphenyl ethers (PBDEs) may affect male reproductive function. The aim of the present study was to evaluate if male reproductive function was associated with serum level of PBDEs. We evaluated, in a cross-sectional study, the effects of environmental exposure to BDE-47 and BDE-153 on reproductive hormones and semen quality, including markers of DNA damage and apoptosis, in 299 spouses of pregnant women from Greenland, Poland and Ukraine. Adjusted linear regression models indicated no strong associations between BDE-47 or BDE-153 exposure and markers of male semen quality or reproductive hormones. In the largest study to date we demonstrate that BDE-47 and BDE-153 exposure was not associated with altered semen characteristics or reproductive hormones, indicating that male reproductive function is not affected by the exposure level of these compounds in fertile European or Arctic populations.
authors: Gunnar
authors: G
authors: Toft
authors: Virissa
authors: V
authors: Lenters
authors: Roel
authors: R
authors: Vermeulen
authors: Dick
authors: D
authors: Heederik
authors: Cathrine
authors: C
authors: Thomsen
authors: Georg
authors: G
authors: Becher
authors: Aleksander
authors: A
authors: Giwercman
authors: Davide
authors: D
authors: Bizzaro
authors: Gian Carlo
authors: GC
authors: Manicardi
authors: Marcello
authors: M
authors: Spanò
authors: Lars
authors: L
authors: Rylander
authors: Henning S
authors: HS
authors: Pedersen
authors: Paweł
authors: P
authors: Struciński
authors: Valentyna
authors: V
authors: Zviezdai
authors: Jens Peter
authors: JP
authors: Bonde
mesh_terms: D000328:Adult; D004249:DNA Damage; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000097:blood*; D004958:Estradiol / Q000097:blood; D005411:Flame Retardants / Q000032:analysis*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006116:Greenland; D055768:Halogenated Diphenyl Ethers / Q000097:blood*; D006801:Humans; D020287:In Situ Nick-End Labeling; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011044:Poland; D011075:Polybrominated Biphenyls / Q000097:blood*; D013076:Sperm Count; D013081:Sperm Motility; D013739:Testosterone / Q000097:blood; D014455:Ukraine; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D011075:Polybrominated Biphenyls; C517828:hexabrominated diphenyl ether 153; C511295:2,2',4,4'-tetrabromodiphenyl ether; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone