title: Low-density microparticles with petaloid surface structure for pulmonary drug delivery.
abstract: The morphology of spray-dried particles composed of psicose and hydroxypropyl methylcellulose was modified by adding ammonium bicarbonate (ABC) to the solution. The surface structure of the particles was altered by immediate transformation of ABC to gaseous components during the spray drying. As a result, low-density microparticles with a petaloid surface structure, which was controllable by changing the evaporation rate of ABC, was obtained. This technique should be useful for modifying characteristics of solid particles for pulmonary drug delivery.
authors: Biomaterials Unit, International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Ibaraki, 305-0044, Japan.
authors: Kohsaku
authors: K
authors: Kawakami
authors: Yusuke
authors: Y
authors: Hasegawa
authors: Shaoling
authors: S
authors: Zhang
authors: Yasuo
authors: Y
authors: Yoshihashi
authors: Etsuo
authors: E
authors: Yonemochi
authors: Katsuhide
authors: K
authors: Terada
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols / Q000737:chemistry*; D001639:Bicarbonates / Q000737:chemistry*; D003890:Desiccation; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D005632:Fructose / Q000737:chemistry*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D010316:Particle Size; D013499:Surface Properties
chemical_list: D000336:Aerosols; D001639:Bicarbonates; D004337:Drug Carriers; C003243:psicose; D005632:Fructose; D065347:Hypromellose Derivatives; C027043:ammonium bicarbonate; D008747:Methylcellulose
keywords: aerosol; ammonium bicarbonate; excipients; microparticles; petaloid structure; pulmonary drug delivery; spray drying