title: Interleukin-17A in lipid metabolism and atherosclerosis.
abstract: Interleukin-17 (IL-17) A, the most important cytokine of the IL-17 family predominantly secreted by T helper 17 (Th17) cells, plays a critical role in the development of inflammatory diseases. Its receptor is an obligate heterodimer composed of IL-17 receptor (IL-17R) A and C, the main members of the IL-17R family. Binding of IL-17A to the IL-17RA/C complex can activate a variety of downstream signaling pathways such as nuclear factor kappa-B (NF-κB), activator protein 1 (AP1) and CCAAT/enhancer-binding protein (C/EBP) to induce the expression of proinflammatory cytokines and chemokines. IL-17A also promotes mRNA stability. Growing evidence shows that IL-17A is involved in lipid metabolism and the pathogenesis of atherosclerosis, a chronic inflammatory arterial disease driven by both innate and adaptive immune responses to modified lipoproteins. In the current review, we describe recent progress on regulation and signaling of IL-17A, and highlight its impacts on lipid metabolism and atherosclerosis.
authors: Life Science Research Center, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China.
authors: Xiao-Hua
authors: XH
authors: Yu
authors: Department of Electrocardiogram, the Second Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China.
authors: Na
authors: N
authors: Jiang
authors: Department of Biochemistry and Molecular Biology, The Libin Cardiovascular Institute of Alberta, The University of Calgary, Health Sciences Center, 3330 Hospital Dr NW, Calgary, Alberta, T2N 4N1, Canada.
authors: Xi-Long
authors: XL
authors: Zheng
authors: Department of Physiology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
authors: Francisco S
authors: FS
authors: Cayabyab
authors: Department of Orthopedics, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China. Electronic address: 2682446780@qq.com.
authors: Zhi-Bin
authors: ZB
authors: Tang
authors: Life Science Research Center, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, China. Electronic address: tangchaoke@qq.com.
authors: Chao-Ke
authors: CK
authors: Tang
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D050356:Lipid Metabolism / Q000502:physiology*; D053722:Receptors, Interleukin-17 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17
keywords: Atherosclerosis; IL-17A; IL-17RA; IL-17RC; Lipid metabolism