title: Incidence and metastasis of cutaneous malignant melanoma with respect to ABO blood groups: a case-controlled study in northeast of China.
abstract: BACKGROUND
  ABO blood groups have been suggested to contribute to the development of certain tumors; however, the associations between ABO blood groups and the incidence and metastases of cutaneous malignant melanomas have not been fully evaluated in Chinese populations. Thus, we investigated these associations with a case-controlled study in northeast of China.
  
  
  METHODS
  A total of 482 patients with cutaneous malignant melanoma and 3,068 healthy- controls were enrolled for the study between 2001 and 2012 at The Tumor Hospital of Harbin Medical University. A multivariate logistic model was used to evaluate adjusted odds ratios (ORs) and 95% confidence intervals (CI) for the incidence and metastases of cutaneous malignant melanoma.
  
  
  RESULTS
  Blood type A individuals had higher tumor incidence and metastasis compared to those with blood type O (OR = 1.575; 95% CI = 1.208-2.053, p = 0.001; OR = 2.004; 95% CI = 1.032-3.889, p = 0.040), after adjusting for age, gender, smoking status and alcohol consumption.
  
  
  CONCLUSIONS
  Blood type A was associated with higher incidence and metastasis of cutaneous malignant melanoma but future studies are needed to examine the mechanisms linking cutaneous malignant melanoma to ABO blood types.
authors: Department of Neurosurgery, The Tumor Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors: Liang
authors: L
authors: Chang
authors: Chinese Center for Endemic Disease Control, Harbin Medical University, Harbin, People's Republic of China ; The Key Laboratory for Etiological Epidemiology of the Ministry of Health, Harbin Medical University, Harbin, People's Republic of China.
authors: Junrui
authors: J
authors: Pei
authors: Department of Neurosurgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors: Chenlong
authors: C
authors: Li
authors: Department of Neurosurgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors: Ping
authors: P
authors: Zhang
authors: Department of Neurosurgery, The Tumor Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors: Dan
authors: D
authors: Zhou
authors: Department of Neurosurgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors: Wenzhong
authors: W
authors: Du
authors: Department of Neurosurgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors: Xing
authors: X
authors: Liu
authors: Department of Neurosurgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
authors: Chuanlu
authors: C
authors: Jiang
mesh_terms: D000017:ABO Blood-Group System; D000368:Aged; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008545:Melanoma / Q000097:blood / Q000453:epidemiology* / Q000556:secondary; D008875:Middle Aged; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000473:pathology
chemical_list: D000017:ABO Blood-Group System