title: New hydrazines with sulphonamidic structure: synthesis,characterization and biological activity.
abstract: Infections caused by bacterial species are common in immunocompromised patients and carry significant treatment costs and mortality. The emerging resistance of microorganisms to some synthetic antimicrobial agents makes it necessary to continue the research for new antimicrobial drugs.
  
  
  OBJECTIVE
  To design new sulphonamide compounds with potential antibacterial and antioxidant activity.
  
  
  METHODS
  New N-hydrazino acetyl-sulphonamides were prepared by condensation of some sulphonamides with chloroacetyl chloride and amination of intermediate compounds with hydrazine hydrate.
  
  
  RESULTS
  The synthesized compounds were screened for their antibacterial activity against Gram positive (Klebsiellapneumoniae. Proteus vulgaris, Citrobacter freundii, Enterobacter cloacae, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis) and Gram negative bacterial strains (Pseudomonas aeruginosa, Escherichia coli). Some of them were found to have good antibacterial activity. The antioxidant activity of these compounds was also tested using different methods: total antioxidant capacity, reducing power, and DPPH radical scavenging activity.
  
  
  CONCLUSIONS
  Chemical modulations performed on sulphonamide structure have a good influence on the biological activity of the synthesized compounds, especially on their antioxidant effects.
authors: Faculty of Pharmacy, University of Medicine and Pharmacy Grigore T. Popa, Iasi.
authors: Oana Maria
authors: OM
authors: Parasca
authors: Discipline of Pharmaceutical Chemistry, University of Medicine and Pharmacy Grigore T. Popa, Iasi.
authors: Florentina
authors: F
authors: Lupascu
authors: Romanian Academy, P. Poni Institute of Macromolecular Chemistry, University of Medicine and Pharmacy Grigore T. Popa, Iasi.
authors: Cornelia
authors: C
authors: Vasile
authors: Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Iasi.
authors: M
authors: M
authors: Mares
authors: Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine of Iasi.
authors: V
authors: V
authors: Nastasa
authors: Discipline of Pharmaceutical Chemistry, University of Medicine and Pharmacy Grigore T. Popa, Iasi.
authors: Lenuta
authors: L
authors: Profire
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000586:Amination; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012997:Solvents / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000085:Acetates; D000890:Anti-Infective Agents; D000975:Antioxidants; D006834:Hydrazines; D012997:Solvents; D013449:Sulfonamides; C029424:hydrazine; C045557:chloroacetyl chloride