title: Chitin-based fast responsive pH sensitive microspheres for controlled drug release.
abstract: Ionically crosslinked chitin microspheres were prepared by using electrostatic droplet method and the drug release from the microspheres was controlled by adjusting external pH. Specifically, chitin was dissolved in NaOH/urea solution at low temperature and functionalized with acrylamide moieties. Acrylamide-modified chitin microspheres with a diameter of 400-500 μm can be obtained at the voltage of 6 kV and the pump speed of 5 mL h(-1). The formed microspheres were ionically crosslinked with Fe(3+) and then complexed with polycationic polysaccharide chitosan. The structure of the microspheres was characterized by FT IR, SEM, and EDS analyses. Besides, the drug release behavior of the microspheres exhibited a fast responsive and pH sensitive release of vancomycin. It took 30 h for complete release of vancomycin in pH 4.0 buffer and pH 1.2 HCl solution while a fast release (10 min) occurred in pH 7.4 buffer. The results showed that the microspheres could be used in drug delivery.
authors: School of Resource and Environmental Science and Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China.
authors: Yu
authors: Y
authors: Shang
authors: School of Resource and Environmental Science and Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China.
authors: Fuyuan
authors: F
authors: Ding
authors: School of Resource and Environmental Science and Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China.
authors: Ling
authors: L
authors: Xiao
authors: School of Resource and Environmental Science and Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China.
authors: Hongbing
authors: H
authors: Deng
authors: School of Resource and Environmental Science and Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China.
authors: Yumin
authors: Y
authors: Du
authors: School of Resource and Environmental Science and Hubei Biomass-Resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan 430079, China. Electronic address: shixwwhu@163.com.
authors: Xiaowen
authors: X
authors: Shi
mesh_terms: D002686:Chitin / Q000737:chemistry*; D004337:Drug Carriers; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004337:Drug Carriers; D002686:Chitin
keywords: Chitin microsphere; Drug delivery; Electrostatic droplet method; Ionically crosslinked; pH sensitive