title: A dual-modal retinal imaging system with adaptive optics.
abstract: An adaptive optics scanning laser ophthalmoscope (AO-SLO) is adapted to provide optical coherence tomography (OCT) imaging. The AO-SLO function is unchanged. The system uses the same light source, scanning optics, and adaptive optics in both imaging modes. The result is a dual-modal system that can acquire retinal images in both en face and cross-section planes at the single cell level. A new spectral shaping method is developed to reduce the large sidelobes in the coherence profile of the OCT imaging when a non-ideal source is used with a minimal introduction of noise. The technique uses a combination of two existing digital techniques. The thickness and position of the traditionally named inner segment/outer segment junction are measured from individual photoreceptors. In-vivo images of healthy and diseased human retinas are demonstrated.
authors: Alexander
authors: A
authors: Meadway
authors: Christopher A
authors: CA
authors: Girkin
authors: Yuhua
authors: Y
authors: Zhang
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D005246:Feedback; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007909:Lenses; D018613:Microscopy, Confocal / Q000295:instrumentation*; D015203:Reproducibility of Results; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000473:pathology*; D042261:Retinoscopes; D012680:Sensitivity and Specificity