title: Malignant uveal schwannoma with peripheral nerve extension in a 12-week-old color-dilute Labrador Retriever.
abstract: The formalin-fixed, amber-colored right globe from a 12-week-old female silver Labrador Retriever dog was submitted to the Comparative Ocular Pathology Laboratory of Wisconsin for light microscopic evaluation. The clinical history described a collapsed anterior chamber and multifocal nodular lesions in the peripheral iris. Histologically, immunohistochemically, and ultrastructurally, the uveal mass was consistent with a malignant schwannoma; there was extension along peripheral nerves within the sclera. The signalment and behavior of the neoplasm distinguish it from the uveal schwannoma of blue-eyed dogs and bear some resemblance to the ocular lesions in human neurofibromatosis. The dilute color mutation may contribute to the cause. Six weeks later, the dog did not develop any additional masses.
authors: School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors: F D
authors: FD
authors: Duke
authors: School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA lteixeira@wisc.edu.
authors: L B C
authors: LB
authors: Teixeira
authors: Mississippi Veterinary Ophthalmology Specialists, Ocean Springs, Mississippi, USA.
authors: L E
authors: LE
authors: Galle
authors: Animal Care Center, Mobile, Alabama, USA.
authors: N
authors: N
authors: Green
authors: School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.
authors: R R
authors: RR
authors: Dubielzig
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005123:Eye; D005260:Female; D009154:Mutation; D018317:Nerve Sheath Neoplasms / Q000473:pathology / Q000662:veterinary*; D009442:Neurilemmoma / Q000473:pathology / Q000662:veterinary*; D010525:Peripheral Nerves / Q000473:pathology
keywords: canine; color dilute; eye; juvenile; neurofibromatosis; schwannoma; uveal schwannoma of blue-eyed dogs