title: Dickkopf-1 levels in Turkish patients with bladder cancer and its association with clinicopathological features.
abstract: BACKGROUND
  Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. The aim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients with bladder cancer.
  
  
  METHODS
  DKK-1 levels were determined in serum samples from 90 patients with bladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by using enzyme linked immune-sorbent assay (ELISA).
  
  
  RESULTS
  Elevated preoperative DKK-1 levels were associated with tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001).
  
  
  CONCLUSIONS
  The results of our study demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase in the tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determination of bladder cancer and the detection of patients with a likely poor clinical outcome.
authors: Department of Urology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey E-mail : necippirincci@hotmail.com.
authors: Mehmet
authors: M
authors: Kaba
authors: Necip
authors: N
authors: Pirincci
authors: Erdal
authors: E
authors: Benli
authors: Ilhan
authors: I
authors: Gecit
authors: Mustafa
authors: M
authors: Gunes
authors: Mehmet Bilgehan
authors: MB
authors: Yuksel
authors: Adem
authors: A
authors: Tok
authors: Ahu Sarbay
authors: AS
authors: Kemik
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D047368:Tumor Burden; D014421:Turkey; D001749:Urinary Bladder Neoplasms / Q000097:blood* / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins