title: Host-guest inclusion system of norathyriol with β-cyclodextrin and its derivatives: preparation, characterization, and anticancer activity.
abstract: The characterization, binding ability and inclusion complexation behavior of the inclusion complexes of norathyriol with β-cyclodextrin (β-CD) and its derivatives such as hydroxypropyl-β-cyclodextrin (HPβCD), sulfobutyl ether β-cyclodextrin (SBEβCD) and mono (6-ethylene-diamino-6-deoxy)-β-cyclodextrin (ENβCD) were investigated in both solution and solid state by means of femtosecond spectroscopy, (1)H and 2D nuclear magnetic resonance, powder X-ray diffraction. The results showed that the aqueous solubility of the complexes was much higher than that of norathyriol. The cytotoxicity of complexes on human colon cancer cell lines HT-29, SW480, Lovo and HCT116 indicated that the antitumor activities of the complexes were better than that of norathyriol. This high antitumor activity, along with the satisfactory aqueous solubility of the complexes, will be potentially useful for their application on cancer chemotherapies.
authors: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
authors: Bin
authors: B
authors: Han
authors: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China. Electronic address: yangbo6910@sina.com.
authors: Bo
authors: B
authors: Yang
authors: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
authors: Xuemin
authors: X
authors: Yang
authors: Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650500, PR China.
authors: Yulin
authors: Y
authors: Zhao
authors: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
authors: Xiali
authors: X
authors: Liao
authors: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
authors: Chuanzhu
authors: C
authors: Gao
authors: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
authors: Fen
authors: F
authors: Wang
authors: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, PR China.
authors: Ruijian
authors: R
authors: Jiang
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000494:pharmacology; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D033362:Powder Diffraction; D012995:Solubility; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D005029:Ethylenediamines; D047392:beta-Cyclodextrins; C557802:ethylene-diamine-beta-cyclodextrin; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C093196:SBE4-beta-cyclodextrin
keywords: Anticancer activity; Binding ability; Characterization; Inclusion complex; Norathyriol; β-Cyclodextrin