title: SurvMicro: assessment of miRNA-based prognostic signatures for cancer clinical outcomes by multivariate survival analysis.
abstract: MicroRNAs (miRNAs) play a key role in post-transcriptional regulation of mRNA levels. Their function in cancer has been studied by high-throughput methods generating valuable sources of public information. Thus, miRNA signatures predicting cancer clinical outcomes are emerging. An important step to propose miRNA-based biomarkers before clinical validation is their evaluation in independent cohorts. Although it can be carried out using public data, such task is time-consuming and requires a specialized analysis. Therefore, to aid and simplify the evaluation of prognostic miRNA signatures in cancer, we developed SurvMicro, a free and easy-to-use web tool that assesses miRNA signatures from publicly available miRNA profiles using multivariate survival analysis. SurvMicro is composed of a wide and updated database of >40 cohorts in different tissues and a web tool where survival analysis can be done in minutes. We presented evaluations to portray the straightforward functionality of SurvMicro in liver and lung cancer. To our knowledge, SurvMicro is the only bioinformatic tool that aids the evaluation of multivariate prognostic miRNA signatures in cancer.
  
  
  METHODS
  SurvMicro and its tutorial are freely available at http://bioinformatica.mty.itesm.mx/SurvMicro.
authors: Departamento de Investigación e Innovación, Escuela de Medicina, Tecnológico de Monterrey, 64849 México.
authors: Raul
authors: R
authors: Aguirre-Gamboa
authors: Departamento de Investigación e Innovación, Escuela de Medicina, Tecnológico de Monterrey, 64849 México.
authors: Victor
authors: V
authors: Trevino
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000401:mortality; D008175:Lung Neoplasms / Q000235:genetics / Q000401:mortality; D035683:MicroRNAs / Q000378:metabolism*; D015999:Multivariate Analysis; D009369:Neoplasms / Q000401:mortality*; D011379:Prognosis; D012984:Software; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs