title: Bringing dead proteins back to life.
abstract: A small molecule called EMD 57033 can repair motor proteins that have stopped working as a result of stress.
authors: Brandon A Wustman is at OrPhi Therapeutics, Carlsbad, United States bwustman@orphitherapeutics.com.
authors: Brandon
authors: B
authors: A Wustman
authors: John W
authors: JW
authors: Steele
authors: Eric R
authors: ER
authors: Sjoberg
authors: Anthony C
authors: AC
authors: Stevens
mesh_terms: D000818:Animals; D024722:Cardiac Myosins / Q000378:metabolism*; D002316:Cardiotonic Agents / Q000494:pharmacology*; D020536:Enzyme Activators / Q000494:pharmacology*; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects*; D032383:Myocytes, Cardiac / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*; D013829:Thiadiazines / Q000494:pharmacology*
chemical_list: D002316:Cardiotonic Agents; D020536:Enzyme Activators; D011804:Quinolines; D013829:Thiadiazines; D024722:Cardiac Myosins
keywords: allostery; myosin; pharmacological chaperone; protein folding