title: The high molecular weight adiponectin level is associated with the atherogenic lipoprotein profiles in healthy Japanese males.
abstract: OBJECTIVE
  Circulating adiponectin comprises high, medium and low molecular weight (HMW, MMW, and LMW) forms. Decreased adiponectin levels have been demonstrated to correlate with the atherogenic lipoprotein profile in patients with metabolic syndrome(MS). However, the associations of these isoforms with the atherogenic lipoprotein profiles in the healthy population remain unclear.
  
  
  METHODS
  Apparently healthy male subjects were divided into non-MS(n=132) and MS(n=63) groups. We measured the total, HMW, MMW and LMW adiponectin levels by ELISA, and determined the detailed lipoprotein profiles by high-performance liquid chromatography.
  
  
  RESULTS
  The total and HMW adiponectin levels in the MS group were significantly lower than those in the non-MS group(3.8±1.9 vs. 4.9±2.4μg/mL, p＜0.001 and 1.6±1.2 vs. 2.5±1.9μg/mL, p＜0.001, respectively), whereas the MMW and LMW levels did not differ significantly between the groups. The total and HMW adiponectin levels correlated with the atherogenic lipoprotein profiles, including the following: 1) increased cholesterol levels in the small LDL subclasses; 2) decreased cholesterol levels in the larger HDL subclasses; 3) increased triglycerides(TGs) in almost all VLDL and LDL subclasses and 4) decreased TGs in the large HDL and increased TGs in the small HDL subclasses. In addition, a multivariate analysis demonstrated that the HMW adiponectin level was an independent predictor of the small LDL and HDL levels(p=0.02 for both).
  
  
  CONCLUSIONS
  The HMW, but not MMW or LMW, adiponectin levels are associated with the typical atherogenic lipoprotein profiles, independent of MS components. Measurement of the HMW adiponectin levels could be useful for identifying the atherogenicity in apparently healthy males.
authors: Department of Cardiovascular Medicine, Juntendo University School of Medicine.
authors: Tetsuro
authors: T
authors: Miyazaki
authors: Makoto
authors: M
authors: Hiki
authors: Kazunori
authors: K
authors: Shimada
authors: Atsumi
authors: A
authors: Kume
authors: Takashi
authors: T
authors: Kiyanagi
authors: Katsuhiko
authors: K
authors: Sumiyoshi
authors: Hirotoshi
authors: H
authors: Ohmura
authors: Hiroyuki
authors: H
authors: Daida
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050197:Atherosclerosis / Q000097:blood / Q000473:pathology*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000473:pathology*; D008875:Middle Aged; D008970:Molecular Weight; D011379:Prognosis
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D008074:Lipoproteins