title: CASPASE-12 and rheumatoid arthritis in African-Americans.
abstract: CASPASE-12 (CASP12) has a downregulatory function during infection and thus may protect against inflammatory disease. We investigated the distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 alleles were genotyped in 953 RA patients and 342 controls. Statistical analyses comparing genotype groups were performed using Kruskal-Wallis non-parametric ANOVA with Mann-Whitney U tests and chi-square tests. There was no significant difference in the overall distribution of CASP12 genotypes within AA with RA, but CASP12 homozygous patients had lower baseline joint-narrowing scores. CASP12 homozygosity appears to be a subtle protective factor for some aspects of RA in AA patients.
authors: Public Health Program, College of Education and Health Sciences, Touro University-CA, Vallejo, CA, USA.
authors: Laura
authors: L
authors: Marshall
authors: Mohammad
authors: M
authors: Obaidullah
authors: Trista
authors: T
authors: Fuchs
authors: Naomi S
authors: NS
authors: Fineberg
authors: Garland
authors: G
authors: Brinkley
authors: Ted R
authors: TR
authors: Mikuls
authors: S Louis
authors: SL
authors: Bridges
authors: Evan
authors: E
authors: Hermel
mesh_terms: D000328:Adult; D001741:Black or African American / Q000235:genetics*; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000201:enzymology* / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D053454:Caspase 12 / Q000235:genetics* / Q000276:immunology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006720:Homozygote; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011544:Pseudogenes
chemical_list: D018836:Inflammation Mediators; C506444:CASP12 protein, human; D053454:Caspase 12