title: Girl power: estrogen promotes HSC self-renewal.
abstract: Although some hematopoietic cell types are known to respond to sex hormones, hematopoietic stem cells (HSCs) are generally thought to function similarly in both sexes. Recently in Nature, Nakada et al. (2014) show that HSCs respond to higher levels of estrogen in females, resulting in enhanced self-renewal and increased erythropoiesis.
authors: Immune Receptors of the Innate and Adaptive System Team, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centre Esther Koplovitz, Rosselló, 149-153, 08036 Barcelona, Spain.
authors: Esther
authors: E
authors: Carreras
authors: Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, 825 NE 13(th) Street, Oklahoma City, OK 73104, USA. Electronic address: susan-kovats@omrf.org.
authors: Susan
authors: S
authors: Kovats
mesh_terms: D000818:Animals; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D008297:Male; D011247:Pregnancy
chemical_list: D004967:Estrogens