title: Changes in iron metabolism and oxidative status in STZ-induced diabetic rats treated with bis(maltolato) oxovanadium (IV) as an antidiabetic agent.
abstract: The role of vanadium as a micronutrient and hypoglycaemic agent has yet to be fully clarified. The present study was undertaken to investigate changes in the metabolism of iron and in antioxidant defences of diabetic STZ rats following treatment with vanadium. Four groups were examined: control; diabetic; diabetic treated with 1 mgV/day; and Diabetic treated with 3 mgV/day. The vanadium was supplied in drinking water as bis(maltolato) oxovanadium (IV) (BMOV). The experiment had a duration of five weeks. Iron was measured in food, faeces, urine, serum, muscle, kidney, liver, spleen, and femur. Superoxide dismutase, catalase,
  quinone-oxidoreductase-1 (NQO1) activity, and protein carbonyl group levels in the liver were determined. In the diabetic rats, higher levels of Fe absorbed, Fe content in kidney, muscle, and femur, and NQO1 activity were recorded, together with decreased catalase activity, in comparison with the control rats. In the rats treated with 3 mgV/day, there was a significant decrease in fasting glycaemia, Fe content in the liver, spleen, and heart, catalase activity, and levels of protein carbonyl groups in comparison with the diabetic group. In conclusion BMOV was a dose-dependent hypoglycaemic agent. Treatment with 3 mgV/day provoked increased Fe deposits in the tissues, which promoted a protein oxidative damage in the liver.
authors: Department of Physiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
authors: Cristina
authors: C
authors: Sánchez-González
authors: Department of Physiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
authors: Carlos
authors: C
authors: López-Chaves
authors: Department of Cellular Biology, Faculty of Sciences, University of Granada, 18071 Granada, Spain.
authors: Cristina E
authors: CE
authors: Trenzado
authors: Department of Physiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
authors: Pilar
authors: P
authors: Aranda
authors: Department of Physiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
authors: María
authors: M
authors: López-Jurado
authors: Department of Analytical Chemistry, Faculty of Chemistry, University of Oviedo, 33007 Oviedo, Spain.
authors: Jorge
authors: J
authors: Gómez-Aracena
authors: Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Málaga, 29071 Málaga, Spain.
authors: María
authors: M
authors: Montes-Bayón
authors: Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Málaga, 29071 Málaga, Spain.
authors: Alfredo
authors: A
authors: Sanz-Medel
authors: Department of Physiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.
authors: Juan
authors: J
authors: Llopis
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D010084:Oxidation-Reduction; D011753:Pyrones / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D014638:Vanadates / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D007004:Hypoglycemic Agents; D011753:Pyrones; C074212:bis(maltolato)oxovanadium(IV); D014638:Vanadates; D007501:Iron; D002374:Catalase; D013482:Superoxide Dismutase; D016660:NAD(P)H Dehydrogenase (Quinone)