title: Walking while talking in patients with multiple sclerosis: the impact of specific cognitive loads.
abstract: OBJECTIVE
  Gait and cognitive disorders are frequently reported in patients with multiple sclerosis, leading to decreased quality of live. The objective of this prospective study was to examine the impact of four specific cognitive tasks on gait in patients with relapsing-remitting multiple sclerosis (RRMS) with low disability.
  
  
  METHODS
  The mean±standard deviation (SD) of walking speed, stride time and stride length were measured in 25 patients with RRMS (age: 39.46±8.32years; Expanded Disability Status Scale [EDSS] score: 1.90±1.01; disease duration: 5.62±5.12years) and in 25 age-matched controls. Gait was assessed during single task and while doing four different cognitive tasks (forward counting, backward counting, semantic verbal fluency, phonemic verbal fluency). Spatiotemporal gait parameters were recorded by a 12-camera optoelectronic system.
  
  
  RESULTS
  Patients walked slower and with a decrease stride length during the single task and the four dual tasks than controls, except for the condition of backward counting. RRMS patients and controls presented the same cognitive performances for the four conditions during walking. EDSS score was correlated with gait speed and stride length in single task, and in the dual tasks of the backward counting and phonemic fluency.
  
  
  CONCLUSIONS
  Quantitative gait assessment reveals subtle gait disorders in patients with low disability of relapsing-remitting multiple sclerosis. The impact of different cognitive domains on gait induces specific gait disturbances that highlight the strong interaction between gait and cognition.
authors: Department of clinical neurosciences, division of neurology, Geneva university hospitals, university of Geneva, 4, rue Gabrielle-Perret-Gentil, Geneva, Switzerland; Department of neurology, Albert Einstein college of medicine, Yeshiva university, Bronx, New York, USA. Electronic address: gilles.allali@hcuge.ch.
authors: G
authors: G
authors: Allali
authors: Department of clinical neurosciences, division of neurology, Geneva university hospitals, university of Geneva, 4, rue Gabrielle-Perret-Gentil, Geneva, Switzerland.
authors: M
authors: M
authors: Laidet
authors: Department of clinical neurosciences, division of neurology, Geneva university hospitals, university of Geneva, 4, rue Gabrielle-Perret-Gentil, Geneva, Switzerland.
authors: F
authors: F
authors: Assal
authors: Willy Taillard laboratory of kinesiology, Geneva university hospitals, Geneva university, Geneva, Switzerland.
authors: S
authors: S
authors: Armand
authors: Department of clinical neurosciences, division of neurology, Geneva university hospitals, university of Geneva, 4, rue Gabrielle-Perret-Gentil, Geneva, Switzerland; Department of genetic and laboratory medicine, division of laboratory medicine, university hospital of Geneva, 1211 Geneva, Switzerland.
authors: P H
authors: PH
authors: Lalive
mesh_terms: D000328:Adult; D003071:Cognition; D005260:Female; D020233:Gait Disorders, Neurologic / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D016138:Walking
keywords: Double tâche; Dual task; Gait disorders; Multiple sclerosis; Neuropsychologie; Neuropsychology; Sclérose en plaques; Troubles de la marche