title: Experimental study on sustained-release 5-Fluorouracil implantation in canine peritoneum and para-aortic abdominalis.
abstract: OBJECTIVE
  To observe local and systemic toxicity after sustained-release 5-fluorouracil (5-Fu) implantation in canine peritoneum and para-aortic abdominalis and the changes of drug concentration in the local implanted tissue with time.
  
  
  METHODS
  300 mg sustained-release 5-Fu was implanted into canine peritoneum and para-aorta abdominalis. Samples were taken 3, 5, 7 and 10 days after implantation for assessment of changes and systemic reactions. High performance liquid chromatography was applied to detect the drug concentrations of peritoneal tissue at different distances from the implanted site, lymphatic tissue of para-aortic abdominalis, peripheral blood and portal venous blood.
  
  
  RESULTS
  10 days after implantation, the drug concentrations in the peritoneum, lymphatic tissue and portal vein remained relatively high within 5 cm of the implanted site. There appeared inflammatory reaction in the local implanted tissue, but no visible pathological changes such as cell degeneration and necrosis, and systemic reaction like anorexia, nausea, vomiting and fever.
  
  
  CONCLUSIONS
  Sustained-release 5-Fu implantation in canine peritoneum and para-aortic abdominalis can maintain a relatively high tumour- inhibiting concentration for a longer time in the local implanted area and portal vein, and has mild local and systemic reactions. Besides, it is safe and effective to prevent or treat recurrence of gastrointestinal tumours and liver metastasis.
authors: Department of General Surgery, Changhai Hospital Affiliated to The Second Military Medical University, Shanghai, China E-mail : wsl29@126.com; bijii@medmail.com.cn.
authors: Guo
authors: G
authors: Wei
authors: Ming-Ming
authors: MM
authors: Nie
authors: Xiao-Jun
authors: XJ
authors: Shen
authors: Xu-Chao
authors: XC
authors: Xue
authors: Li-Ye
authors: LY
authors: Ma
authors: Cheng-Hui
authors: CH
authors: Du
authors: Shi-Liang
authors: SL
authors: Wang
authors: Jian-Wei
authors: JW
authors: Bi
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000097:blood / Q000493:pharmacokinetics*; D004285:Dogs; D004343:Drug Implants / Q000009:adverse effects*; D004487:Edema / Q000209:etiology; D005472:Fluorouracil / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008297:Male; D010537:Peritoneum; D013997:Time Factors
chemical_list: D000964:Antimetabolites, Antineoplastic; D004343:Drug Implants; D005472:Fluorouracil