title: Atorvastatin prevents type 2 diabetes mellitus--an experimental study.
abstract: Recent reports of increased diabetes risk have raised concerns regarding the use of statins. The present study was therefore planned to clarify whether atorvastatin can prevent diabetes development in a rat model of type 2 diabetes mellitus. Eight week old male Wistar rats were randomized into three groups (n = 12 each group). Group A was given standard chow diet, while group B and group C were offered high sucrose diet. In addition to high sucrose diet, group C was given atorvastatin (20mg/kg/day) from beginning of study till 26th week. After 26 weeks, a low dose of streptozotocin (15 mg/kg, i.p.) was given to all 3 groups and further followed for 4 weeks. Oral glucose tolerance tests were done at week 4, 26 and week 30. Development of impaired glucose tolerance at week 26 (16.66% vs 100%, P = <0.001) and diabetes at week 30 (16.66% vs 81.81%, P = 0.002) was significantly lower in rats pretreated with atorvastatin along with high sucrose diet viz group C compared to group B rats who received high sucrose diet only respectively. Also, metabolic indices like body weight, hypertriglyceridemia, glucose area under the curve (Gl-AUC) were significantly lower in group C compared to group B (P = <0.05) while insulin resistance (HOMA-IR) was also lower in group C (P = 0.05). This study clearly demonstrates for the first time in a rat model of type 2 diabetes mellitus that atorvastatin prevents development of type 2 diabetes.
authors: Division of Endocrinology and Metabolism, Department of Medicine, University College of Medical Sciences, University of Delhi, Delhi 110095, India. Electronic address: drsvmadhu@gmail.com.
authors: Sri Venkata
authors: SV
authors: Madhu
authors: Division of Endocrinology and Metabolism, Department of Medicine, University College of Medical Sciences, University of Delhi, Delhi 110095, India.
authors: Mohammad
authors: M
authors: Aslam
authors: Department of Pharmacology, University College of Medical Sciences, University of Delhi, Delhi 110095, India.
authors: Vikas
authors: V
authors: Galav
authors: Department of Pharmacology, University College of Medical Sciences, University of Delhi, Delhi 110095, India.
authors: Swapan Kumar
authors: SK
authors: Bhattacharya
authors: Division of Endocrinology and Metabolism, Department of Medicine, University College of Medical Sciences, University of Delhi, Delhi 110095, India.
authors: Aiman Abbas
authors: AA
authors: Jafri
mesh_terms: D000818:Animals; D000069059:Atorvastatin; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism / Q000517:prevention & control*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000517:prevention & control*; D005951:Glucose Tolerance Test; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D011758:Pyrroles / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007328:Insulin; D011758:Pyrroles; D014280:Triglycerides; D002784:Cholesterol; D000069059:Atorvastatin
keywords: Atorvastatin; Glucose area under the curve; Hypertriglyceridemia; Impaired glucose tolerance; Insulin resistance; Type 2 diabetes