title: Biomechanics of Scar Tissue and Uninjured Skin.
abstract: CONCLUSIONS
  Skin exhibits direction-dependent biomechanical behavior, influenced by the structural orientation of its collagen-rich fibrous network and its viscous ground-substance matrix. Injury can affect the skin's structure and composition, thereby greatly influencing the biomechanics and directionality of the resulting scar tissue.
  
  
  BACKGROUND
  A combination of stress-relaxation and tensile failure testing identifies both the tissue's physiologically relevant viscoelastic behavior and resistance to rupture. When studied in mutually orthogonal directions in the plane of the tissue, these measures give insight into the directional properties of healthy tissue, and how they change with injury. By controlling the biomechanics of the wound environment, a new force-modulating dressing has demonstrated the ability to improve healing and reduce scar formation.
  
  
  RESULTS
  Skin and scar biomechanics are typically characterized by using tensile failure, which identifies the tissue's resistance to rupture but offers limited insight into its normal daily function. Characterizing physiologically relevant biomechanics of skin, and how they change with injury, is critical to understand the tissue's ability to resist elongation, bear load, and dissipate energy via viscous means.
  
  
  CONCLUSIONS
  Compared with uninjured skin, scar tissue demonstrates similar high-load stiffness, greatly reduced resistance to failure, reduced low-load compliance, and altered material directionality. These findings, identified through combined stress relaxation and failure testing, suggest morphological changes with injury that are consistent with the viscoelastic and directional changes observed biomechanically. A more complete understanding of the directional, physiologically relevant skin biomechanics can guide the design and critical functional assessment of wound treatments, scaffolds, and tissue-engineered skin replacements.
authors: Biomedical Engineering Department, Jonsson Engineering Center, Rensselaer Polytechnic Institute , Troy, New York.
authors: David T
authors: DT
authors: Corr
authors: McCaig Institute for Bone and Joint Health, University of Calgary , Calgary, Canada . ; Department of Surgery, University of Calgary , Calgary, Canada . ; Department of Medicine, University of Calgary , Calgary, Canada .
authors: David A
authors: DA
authors: Hart