title: Functional rectification of the newly described African henipavirus fusion glycoprotein (Gh-M74a).
abstract: Recent evidence identified multiple Henipavirus species in Africa distinct from those in Southeast Asia and Australia. The reported fusion glycoprotein (F) sequence of the African Gh-M74a strain (GhV-F) is likely incorrect: a single base pair deletion near the N terminus results in multiple aberrancies. Rectifying this by adding single nucleotide insertions results in a GhV-F that now possesses a signal peptide, is efficiently cell surface expressed, exhibits syncytium formation when coexpressed with GhV-G protein, and mediates pseudotyped viral particle entry.
authors: Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, California, USA.
authors: Olivier
authors: O
authors: Pernet
authors: Shannon
authors: S
authors: Beaty
authors: Benhur
authors: B
authors: Lee
mesh_terms: D000349:Africa; D000595:Amino Acid Sequence; D001483:Base Sequence; D045403:Henipavirus / Q000235:genetics* / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D014760:Viral Fusion Proteins / Q000235:genetics* / Q000378:metabolism*; D053586:Virus Internalization
chemical_list: D014760:Viral Fusion Proteins