title: Topical ethosomal capsaicin attenuates edema and nociception in arthritic rats.
abstract: In this study, topical ethosomal formulation of capsaicin was prepared and evaluated for bio-efficacy in arthritic rats. Physical and biological characterizations of prepared capsaicin-loaded nano vesicular systems were also carried out. Ethosomal capsaicin showed significant reduction of rat paw edema along with promising antinociceptive action. The topical antiarthritic efficacy of prepared formulation of capsaicin was found more than that of Thermagel, a marketed gel of capsaicin. From toxicological study, no predictable signs of toxicity such as skin irritation (of experimental rats) were observed. Based on this finding, ethosomal capsaicin could be proposed as an effective as well as a safe topical delivery system for the long-term treatment of arthritis and associated inflammo-musculoskeletal disorders. Such exciting result would eventually enlighten the analgesic and anti-inflammatory potential of capsaicin for topical remedy.
authors: a Department of Pharmaceutical Sciences , Dibrugarh University , Dibrugarh , Assam , India and.
authors: Khomendra
authors: K
authors: Kumar Sarwa
authors: a Department of Pharmaceutical Sciences , Dibrugarh University , Dibrugarh , Assam , India and.|b Aditya Institute of Pharmaceutical Sciences and Research , Surampalem , Andhra Pradesh , India.
authors: Mithun
authors: M
authors: Rudrapal
authors: a Department of Pharmaceutical Sciences , Dibrugarh University , Dibrugarh , Assam , India and.
authors: Bhaskar
authors: B
authors: Mazumder
keywords: Arthritis; capsaicin; ethosomes; transdermal