title: Relationship between mechanical thresholds and limb use in dogs with coxofemoral joint oa-associated pain and the modulating effects of pain alleviation from total hip replacement on mechanical thresholds.
abstract: OBJECTIVE
  To compare von Frey mechanical quantitative sensory thresholds (mQSTvF ) between pelvic limbs in dogs before unilateral total hip replacement (THR) surgery; to correlate ground reaction forces (GRF) with mQSTvF ; to assess changes in mQSTvF after THR surgery.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  Dogs (n = 44).
  
  
  METHODS
  mQSTvF and GRF measured using a pressure sensitive walkway were evaluated before, and 3, 6, and 12 months after, unilateral THR. Measurements were recorded from the affected (operated) pelvic limb (APL) and the non-operated pelvic limb (NPL). Random effects analysis and forwards stepwise linear regression models were used to evaluate the influence of time since surgery and patient factors on mQSTvF thresholds.
  
  
  RESULTS
  There were no significant correlations between mQSTvF data and age, bodyweight or the GRF variables. Preoperative mQSTvF measured at the APL and NPL did not differ (P = .909). mQSTvF thresholds increased significantly after 12 months in NPL (P = .047) and APL (P = .001). In addition to time, APL mQSTvF values were significantly affected by sex (higher in males, P = .010) and body condition score (higher in leaner dogs, P = .035) and NPL mQSTvF values by sex (P = .038).
  
  
  CONCLUSIONS
  Successful unilateral THR results in decreased central sensitization after 12 months.
authors: Comparative Research Laboratories, North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina; Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh.
authors: Andrea
authors: A
authors: Tomas
authors: Denis J
authors: DJ
authors: Marcellin-Little
authors: Simon C
authors: SC
authors: Roe
authors: Alison
authors: A
authors: Motsinger-Reif
authors: B Duncan X
authors: BD
authors: Lascelles
mesh_terms: D000818:Animals; D019644:Arthroplasty, Replacement, Hip / Q000662:veterinary*; D003050:Coccyx; D004283:Dog Diseases / Q000503:physiopathology* / Q000601:surgery; D004285:Dogs; D005260:Female; D005269:Femur; D005684:Gait; D006621:Hip Joint / Q000503:physiopathology; D007593:Joint Instability / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D010147:Pain Measurement / Q000662:veterinary; D011446:Prospective Studies; D020127:Recovery of Function