title: [Hepatic steatosis as diabetes type 2 predictor].
abstract: Non alcoholic fatty liver disease (NAFLD) is associated with obesity, insulin resistance (IR) and increased type 2 diabetes (T2D). Alanine aminotransferase (ALT) is recognized as biochemical marker of NAFLD, currently used as screening for this disease.
  
  
  OBJECTIVE
  To estimate the associations between (ALT) with anthropometric variables, insulin resistance and inflammatory markers in pediatric population.
  
  
  METHODS
  we studied 348 subjects (52.7% females), aged between 4.9 and 15.6 years. Blood samples for measuring: AST, ALT, glycaemia, insulin, lipid profile, hsCRP TNF-α, IL-6 and adiponectin. We calculate HOMA-IR, QUICKI y el HOMA-β. The results are expressed are expressed as median interquartile range. Variables were log10 transformed before Pearson correlations analyze.
  
  
  RESULTS
  Serum ALT levels were positively associated with BMI-SDS (r = 0.335), waist/ height ratio (r = 0.358), insulin (r = 0.33), HOMA-IR (r = 0.33), HOMA-β (r = 0.26), TG/HDL-c (r = 0.2), hsCRP (r = 0.3); and a negative association with QUICKI (r = -0.25) and adiponectin (r = -0.113). Non-association with ALT, glycaemia, TNF-α and IL-6 was found.
  
  
  CONCLUSIONS
  Our study demonstrated that ALT, but not AST, was significantly correlated with of insulin resistance and inflammatory markers, all of them recognized as risk parameters of pre diabetes stage. ALT should be part of the evaluation of all obesity children, mainly those with other cardiometabolic risk factors, since it could predict later development of T2DM. Further imaging studies are necessary to confirm fatty liver disease in this population.
authors: Unidad Endocrinología Pediátrica. División de Pediatría. Pontificia Universidad Católica de Chile.. Calourei@gmail.com.
authors: Carolina
authors: C
authors: Loureiro
authors: Unidad Endocrinología Pediátrica. División de Pediatría. Pontificia Universidad Católica de Chile.. Calourei@gmail.com.
authors: Alejandro
authors: A
authors: Martínez-Aguayo
authors: Departamento de Endocrinología. Pontificia Universidad Católica de Chile. Chile.. Calourei@gmail.com.
authors: Carmen
authors: C
authors: Campino
authors: Departamento de Endocrinología. Pontificia Universidad Católica de Chile. Chile.. Calourei@gmail.com.
authors: Cristián
authors: C
authors: Carvajal
authors: Departamento de Endocrinología. Pontificia Universidad Católica de Chile. Chile.. Calourei@gmail.com.
authors: Carlos
authors: C
authors: Fardella
authors: Unidad Endocrinología Pediátrica. División de Pediatría. Pontificia Universidad Católica de Chile.. Calourei@gmail.com.
authors: Hernán
authors: H
authors: García
mesh_terms: D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood / Q000150:complications* / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D000410:Alanine Transaminase