title: Loading and release of amine drugs by ion-exchange fibers: role of amine type.
abstract: With more production and application of ion-exchange fibers (IEFs), it becomes necessary to understand the interaction between IEFs and amine compounds, an important group of organic drugs and structural components of large organic molecules in biological systems. However, so far few experimental studies have been conducted to systematically investigate the exchanging mechanism of amine compounds to IEFs. Therefore, 15 amine drugs were selected to investigate the effect of amine type on the loading and release of them from the related IEFs. Loading affinity of these drugs by IEFs decreased in the order of secondary, tertiary, and primary. The following items: basicity, aromaticity, molar volume, rotatability, and so on, were emphatically discussed to address the underlying mechanism of drug loading and releasing extent and rate of IEFs. It was evident that strong alkaline drugs strengthened the ionic bond between the amine groups and IEFs, and thus the loading affinity. These results will advance the understanding of the exchanging behavior of IEFs in the drug delivery system.
authors: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
authors: Yanan
authors: Y
authors: Gao
authors: Hongzhuo
authors: H
authors: Liu
authors: Jing
authors: J
authors: Yuan
authors: Yang
authors: Y
authors: Yang
authors: Xin
authors: X
authors: Che
authors: Yanlong
authors: Y
authors: Hou
authors: Sanming
authors: S
authors: Li
mesh_terms: D000588:Amines / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000737:chemistry*; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D000588:Amines; D003692:Delayed-Action Preparations; D007477:Ions; D004364:Pharmaceutical Preparations; D011108:Polymers
keywords: controlled release; kinetics; mathematical model; physicochemical properties; polymeric drug carrier