title: Protective effects of boron on cyclophosphamide induced lipid peroxidation and genotoxicity in rats.
abstract: The aim of the present study was to evaluate the possible protective effect of boron (B) on cyclophosphamide (CYC) induced oxidative stress in rats. Totally, thirty Wistar albino male rats were fed standard rodent diet and divided into 5 equal groups: physiological saline was given intraperitoneally (i.p.) to the control group (vehicle treated), to the second group only 75 mg kg(-1) CYC was given i.p. on the 14th d, and boron was administered (5, 10, and 20 mg kg(-1), i.p.) to the other groups for 14 d and CYC (75 mg kg(-1), i.p.) on the 14th d. CYC caused increase of malondialdehyde and decrease of glutathione levels, decrease of superoxide dismutase activities in erythrocyte and tissues, decrease of erythrocyte, heart, lung, and brain catalase, and plasma antioxidant activities. Also, CYC treatment caused to DNA damage in mononuclear leukocytes. Moreover, B exhibited protective action against the CYC-induced histopathological changes in tissues. However, treatment of B decreased severity of CYC-induced lipid peroxidation and genotoxicity on tissues. In conclusion, B has ameliorative effects against CYC-induced lipid peroxidation and genotoxicity by enhancing antioxidant defence mechanism in rat.
authors: Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, 03030 Afyonkarahisar, Turkey. Electronic address: since@aku.edu.tr.
authors: Sinan
authors: S
authors: Ince
authors: Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Biochemistry, 03030 Afyonkarahisar, Turkey.
authors: Ismail
authors: I
authors: Kucukkurt
authors: Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Pathology, 03030 Afyonkarahisar, Turkey.
authors: Hasan Huseyin
authors: HH
authors: Demirel
authors: Afyon Kocatepe University, Faculty of Veterinary Medicine, Department of Biochemistry, 03030 Afyonkarahisar, Turkey.
authors: Damla Arslan
authors: DA
authors: Acaroz
authors: Usak University, Usak Health Training School, 64100 Usak, Turkey.
authors: Erten
authors: E
authors: Akbel
authors: Afyon Kocatepe University, Faculty of Science and Arts, Department of Biology, 03030 Afyonkarahisar, Turkey.
authors: Ibrahim Hakki
authors: IH
authors: Cigerci
mesh_terms: D000818:Animals; D001895:Boron / Q000737:chemistry / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D003520:Cyclophosphamide / Q000633:toxicity; D004249:DNA Damage / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000032:analysis / Q000097:blood; D020011:Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D020011:Protective Agents; D009569:Nitric Oxide; D008315:Malondialdehyde; D003520:Cyclophosphamide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D001895:Boron
keywords: Boron; Cyclophosphamide; Genotoxicity; Lipid peroxidation; Rat