title: Protective effect of sulfated chitosan of C3 sulfation on glycerol-induced acute renal failure in rat kidney.
abstract: The purpose of this study was to investigate the protective effects of sulfated chitosan of C3 sulfation (TCTS) on the glycerol-induced acute renal failure. Compared with the normal group, rats from model group exhibited collecting duct and medullary ascending limb dilation and casts by glycerol treating. TCTS, which was injected to pretreat rats by glycerol, exerted a protective effect. The results showed that serum creatinine and blood urea nitrogen were markedly increased in glycerol-treated rats. It is proved that TCTS reduced their levels significantly. Ions level in plasma and urine were significantly changed in glycerol-treated rats, whereas TCTS almost recovered their levels back to normal. For female rats, administration of TCTS reduced their mortality. This study showed a noticeable renal morphologic and functional protection by TCTS in glycerol-induced acute renal failure.
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Ronge
authors: R
authors: Xing
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Song
authors: S
authors: Liu
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Huahua
authors: H
authors: Yu
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Yukun
authors: Y
authors: Qin
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Xiaolin
authors: X
authors: Chen
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Kecheng
authors: K
authors: Li
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address: xingronge@qdio.ac.cn.
authors: Pengcheng
authors: P
authors: Li
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000503:physiopathology / Q000517:prevention & control*; D000818:Animals; D002118:Calcium / Q000097:blood / Q000652:urine; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology*; D019610:Cytoprotection / Q000187:drug effects*; D005260:Female; D005990:Glycerol / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D011188:Potassium / Q000097:blood / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D012964:Sodium / Q000097:blood / Q000652:urine; D013329:Structure-Activity Relationship
chemical_list: C480355:chitosan sulfate; D048271:Chitosan; D012964:Sodium; D005990:Glycerol; D011188:Potassium; D002118:Calcium
keywords: Acute renal failure; Protective effect; Sulfated chitosan of C3 sulfation (TCTS)