title: Protective effects of anesthetics on vascular function related to K⁺ channels.
abstract: K(+) channels play an essential role in the membrane potential of arterial smooth muscle, and also in regulating contractile tone. Especially, in vascular smooth muscle, the opening of adenosine triphosphate (ATP)-sensitive K(+) (KATP) channels leads to membrane hyperpolarization, resulting in muscle relaxation and vasodilation. This activation also plays a role in tissues during pathophysiologic events such as ischemia, hypoxia, and vasodilatory shock. In this review, we will describe the physiological and pathophysiological roles of vascular smooth muscle KATP channels in relation to the effects of anesthetics. Although accumulated evidence suggests that many anesthetics modify the above function of K(+) channels as a metabolic sensor, further studies are certainly needed to resolve certain issues, especially in clinical settings of anesthesia use.
authors: Shinji
authors: S
authors: Kawahito
authors: Katsutoshi
authors: K
authors: Nakahata
authors: Toshiharu
authors: T
authors: Azma
authors: Yasuhiro
authors: Y
authors: Kuroda
authors: David J
authors: DJ
authors: Cook
authors: Department of Anesthesiology, Tokushima University Hospital, 3-18-15, Kuramoto, Tokushima, 770- 8503, Japan. kawahito@pb4.so-net.ne.jp.
authors: Hiroyuki
authors: H
authors: Kinoshita
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology; D054086:KATP Channels / Q000187:drug effects / Q000378:metabolism; D008564:Membrane Potentials / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D015221:Potassium Channels / Q000187:drug effects* / Q000378:metabolism; D012769:Shock / Q000503:physiopathology; D014664:Vasodilation / Q000502:physiology
chemical_list: D000777:Anesthetics; D054086:KATP Channels; D015221:Potassium Channels