title: Protection of non-human primates against rabies with an adenovirus recombinant vaccine.
abstract: Rabies remains a major neglected global zoonosis. New vaccine strategies are needed for human rabies prophylaxis. A single intramuscular immunization with a moderate dose of an experimental chimpanzee adenovirus (Ad) vector serotype SAd-V24, also termed AdC68, expressing the rabies virus glycoprotein, resulted in sustained titers of rabies virus neutralizing antibodies and protection against a lethal rabies virus challenge infection in a non-human primate model. Taken together, these data demonstrate the safety, immunogenicity, and efficacy of the recombinant Ad-rabies vector for further consideration in human clinical trials.
authors: The Wistar Institute of Anatomy & Biology, Philadelphia, PA, United States.
authors: Z Q
authors: ZQ
authors: Xiang
authors: Centers for Disease Control & Prevention, Atlanta, GA, United States.
authors: L
authors: L
authors: Greenberg
authors: The Wistar Institute of Anatomy & Biology, Philadelphia, PA, United States. Electronic address: ertl@wistar.upenn.edu.
authors: H C
authors: HC
authors: Ertl
authors: The Global Alliance for Rabies Control, Manhattan, KS, United States; Ross University School of Veterinary Medicine, Basseterre, St. Kitts, West Indies.
authors: C E
authors: CE
authors: Rupprecht
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000378:metabolism; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D005260:Female; D015870:Gene Expression; D005822:Genetic Vectors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D011818:Rabies / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D011819:Rabies Vaccines / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology; D011820:Rabies virus / Q000235:genetics / Q000276:immunology*; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D014764:Viral Proteins / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D011819:Rabies Vaccines; D014614:Vaccines, Synthetic; D014764:Viral Proteins
keywords: Adenoviral vaccine; NHP; Rabies virus; VNA