title: A Double-edged Sword: Uric Acid and Neurological Disorders.
abstract: Uric Acid (UA), historically considered as a waste of cellular metabolism, has now received increasing attention because it was found to directly participate in the pathogenesis of many human diseases including neurological disorders. On one hand, low levels of UA are detrimental to the neurons because of its induction it impairs antioxidant capacity in the cell. High levels of UA, on the other hand, lead to an inflammatory response contributing to gout or neuroprotection. In this review, we summarize this biphasic function of uric acid and highlight potential therapeutic targets to treat UA-related neurological diseases.
authors: Center for Metabolic Disease Research, Temple University School of Medicine, Philadelphia PA, 19140, USA.
authors: Pu
authors: P
authors: Fang
authors: Center for Cardiovascular Research, Temple University School of Medicine, Philadelphia PA, 19140, USA ; Department of Pharmacology, Temple University School of Medicine, Philadelphia PA, 19140, USA.
authors: Xinyuan
authors: X
authors: Li
authors: Department of Pharmacology, Temple University School of Medicine, Philadelphia PA, 19140, USA ; Department of Neurology, Temple University School of Medicine, Philadelphia PA, 19140, USA.
authors: Jin Jun
authors: JJ
authors: Luo
authors: Center for Metabolic Disease Research, Temple University School of Medicine, Philadelphia PA, 19140, USA ; Center for Cardiovascular Research, Temple University School of Medicine, Philadelphia PA, 19140, USA ; Sol Sherry Thrombosis, Temple University School of Medicine, Philadelphia PA, 19140, USA ; Department of Pharmacology, Temple University School of Medicine, Philadelphia PA, 19140, USA.
authors: Hong
authors: H
authors: Wang
authors: Center for Metabolic Disease Research, Temple University School of Medicine, Philadelphia PA, 19140, USA ; Center for Cardiovascular Research, Temple University School of Medicine, Philadelphia PA, 19140, USA ; Sol Sherry Thrombosis, Temple University School of Medicine, Philadelphia PA, 19140, USA ; Department of Pharmacology, Temple University School of Medicine, Philadelphia PA, 19140, USA.
authors: Xiao-Feng
authors: XF
authors: Yang
keywords: Caspase-1 activation; Hyperuricemia; Inflammation; Neurological disorders; Uric acid