title: Antifouling potentials of eight deep-sea-derived fungi from the South China Sea.
abstract: Marine-derived microbial secondary metabolites are promising potential sources of nontoxic antifouling agents. The search for environmentally friendly and low-toxic antifouling components guided us to investigate the antifouling potentials of eight novel fungal isolates from deep-sea sediments of the South China Sea. Sixteen crude ethyl acetate extracts of the eight fungal isolates showed distinct antibacterial activity against three marine bacteria (Loktanella hongkongensis UST950701-009, Micrococcus luteus UST950701-006 and Pseudoalteromonas piscida UST010620-005), or significant antilarval activity against larval settlement of bryozoan Bugula neritina. Furthermore, the extract of Aspergillus westerdijkiae DFFSCS013 displayed strong antifouling activity in a field trial lasting 4 months. By further bioassay-guided isolation, five antifouling alkaloids including brevianamide F, circumdatin F and L, notoamide C, and 5-chlorosclerotiamide were isolated from the extract of A. westerdijkiae DFFSCS013. This is the first report about the antifouling potentials of metabolites of the deep-sea-derived fungi from the South China Sea, and the first stage towards the development of non- or low-toxic antifouling agents from deep-sea-derived fungi.
authors: Key Laboratory of Tropical Marine Bio-resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, China.
authors: Xiao-Yong
authors: XY
authors: Zhang
authors: Xin-Ya
authors: XY
authors: Xu
authors: Jiang
authors: J
authors: Peng
authors: Chun-Feng
authors: CF
authors: Ma
authors: Xu-Hua
authors: XH
authors: Nong
authors: Jie
authors: J
authors: Bao
authors: Guang-Zhao
authors: GZ
authors: Zhang
authors: Shu-Hua
authors: SH
authors: Qi
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D057219:Biofouling / Q000517:prevention & control*; D002013:Bryozoa / Q000187:drug effects* / Q000254:growth & development; D005658:Fungi / Q000737:chemistry* / Q000302:isolation & purification; D007814:Larva / Q000187:drug effects; D009792:Oceans and Seas; D012623:Seawater / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents