title: Performance evaluation of a novel potentiometric membrane sensor for determination of atorvastatin in pharmaceutical preparations.
abstract: A novel potentiometric ion-selective PVC membrane sensor for analysis of atorvastatin (AT) in pharmaceutical preparations based on atorvastatin-(tetraphenyl borate), (AT-(TPB)2) as sensing element, tetraphenyl borate as additive and tris-2-ethyl-hexyl phosphate (TOP) as plasticizer solvent was prepared. The electrode shows a good Nernestian response over the concentration range of 0.09-5586 μg mL(-1)of AT with slope of 30.1±0.1 mV/decade and limit of detection0.056μg mL(-1).The response time of sensor is fats (less than 10 sec) and could be used for about one month in the pH range of 4.5-8.0. The electrode exhibit good selectivity for the AT in the presence of large amount of co-drugs and inorganic cations. The method is precise and accurate with mean relative standard deviation of <2%.Atorvastatin is determined successfully in several tablets by the proposed membrane.
authors: Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran. ; Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
authors: Farhad
authors: F
authors: Ahmadi
authors: Department of Medicinal Chemistry, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Islamic Republic of Iran.
authors: Nasim
authors: N
authors: Asaadi
keywords: Analysis of pharmaceutical preparation; Atorvastatin; PVC membrane; Potentiometric sensor