title: Association between the CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility: a meta-analysis.
abstract: To date, epidemiological studies have assessed the association between CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility. However, the results of these studies remained controversial. We aimed to examine the associations by conducting a meta-analysis of case-control studies. A total of 11 studies including 5,093 cases and 5,941 controls evaluated the association between the CYP1A2-164 A/C polymorphism and colorectal cancer susceptibility. No significantly associations were found in all genetic models (CC vs. AA: OR = 1.14, 95 % CI = 0.93-1.40; AC vs. AA: OR = 1.05, 95 % CI = 0.91-1.20; dominant model: OR = 1.08, 95 % CI = 0.95-1.24; recessive model: OR = 1.10, 95 % CI = 0.95-1.28). In the subgroup analysis by ethnicity or source of controls, there were still no significant associations detected in all genetic models. This meta-analysis suggested the CYP1A2-164 A/C polymorphism was not a risk factor for increasing colorectal cancer, further large and well-designed studies are needed to confirm these conclusions.
authors: Department of Oncology, The First People's Hospital of Yueyang, Yueyang, People's Republic of China, jianbinghu@hotmail.com.
authors: Jianbing
authors: J
authors: Hu
authors: Chuan
authors: C
authors: Liu
authors: Qinghua
authors: Q
authors: Yin
authors: Mingzhen
authors: M
authors: Ying
authors: Junhui
authors: J
authors: Li
authors: Lian
authors: L
authors: Li
authors: Chun-xia
authors: CX
authors: Zhou
authors: Yajie
authors: Y
authors: Wang
mesh_terms: D000483:Alleles; D015179:Colorectal Neoplasms / Q000235:genetics*; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias
chemical_list: D019388:Cytochrome P-450 CYP1A2