title: Rational design of biotin-disulfide-coumarin conjugates: a cancer targeted thiol probe and bioimaging.
abstract: Biotin-disulfide-coumarin conjugates are designed and synthesized as novel fluorescent sensors for cancer targeted intracellular thiol imaging in living organisms. In vitro experiments disclose that probe 6 is preferentially taken up by biotin receptor-positive A549 tumor cells through receptor mediated endocytosis.
authors: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors: Danbi
authors: D
authors: Jung
authors: Sukhendu
authors: S
authors: Maiti
authors: Jae Hong
authors: JH
authors: Lee
authors: Joung Hae
authors: JH
authors: Lee
authors: Jong Seung
authors: JS
authors: Kim
mesh_terms: D001710:Biotin / Q000031:analogs & derivatives / Q000378:metabolism; D045744:Cell Line, Tumor; D003374:Coumarins / Q000737:chemistry / Q000378:metabolism; D004220:Disulfides / Q000737:chemistry / Q000378:metabolism; D004705:Endocytosis; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D015335:Molecular Probes / Q000737:chemistry / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D061848:Optical Imaging / Q000379:methods; D017978:Receptors, Growth Factor / Q000032:analysis / Q000378:metabolism
chemical_list: D003374:Coumarins; D004220:Disulfides; D005456:Fluorescent Dyes; D015335:Molecular Probes; D017978:Receptors, Growth Factor; C052136:biotin receptor; D001710:Biotin; C030123:coumarin