title: [Changes of CCK-8, CGRP, SP, and VIP in the colon and the lung tissue of allergic asthma model rats: an experimental observation].
abstract: OBJECTIVE
  To observe changes of cholecystokinin octapeptide (CCK-8), calcitonin gene related peptide (CGRP), substance P (SP), and vasoactive intestinal peptide (VIP) in each tissue of the digestive system of allergic asthma (AA) model rats.
  
  
  METHODS
  The pulmonary disease (AA) rat model was duplicated by 1% ovalbumin. Its effect on the pathological morphology of the six main parts of the digestive system (stomach, duodenum, jejunum, ileum, colon and rectum) and related regulating factors such as CCK8, CGRP, SP, and VIP were observed.
  
  
  RESULTS
  The pathological morphology of the lung was synchronously changed as that of the colon of model rats. But there was no obvious change in the stomach, duodenum, jejunum, ileum, or rectum. Significant changes occurred in CCK8 (79 961.4 +/- 12 577.9, 48 519.5 +/- 12 240.7), CGRP (41 950.1 +/- 12 600.1, 38 059.8 +/- 11 942.4), and SP (88 243.9 +/- 32 177.2, 47 417.8 +/- 16 462.4), and VIP (20 711.4 +/- 7 334.6, 43 208.1 +/- 13 433.8) of the lung tissue and the colon tissue of model rats (P < 0. 05, P < 0.01). But there was no significant change in the aforesaid substances of the stomach, duodenum, jejunum, ileum and rectum (P > 0.05).
  
  
  CONCLUSIONS
  Pulmonary disease might affect the colon, inducing pathological changes of the colon tissue and changes of related regulating factors such as CCK8, CGRP, SP, and VIP. It showed no significant effect on the stomach, duodenum, jejunum, ileum and rectum.
authors: Department of Warm Diseases, College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
authors: Xiu-Li
authors: XL
authors: Zheng
authors: Department of Warm Diseases, College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
authors: Yu
authors: Y
authors: Yang
authors: Department of Warm Diseases, College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
authors: Bao-Jia
authors: BJ
authors: Wang
authors: Department of Warm Diseases, College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
authors: Hong-Qu
authors: HQ
authors: Tang
authors: Department of Warm Diseases, College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
authors: Xu-Rui
authors: XR
authors: Zheng
authors: Department of Warm Diseases, College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
authors: Jian-Hong
authors: JH
authors: Ye
mesh_terms: D000818:Animals; D001249:Asthma / Q000378:metabolism*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D003106:Colon / Q000378:metabolism*; D004195:Disease Models, Animal; D008168:Lung / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012844:Sincalide / Q000378:metabolism; D013373:Substance P / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide; D012844:Sincalide