title: Mycoplasma genitalium: a review.
abstract: Mycoplasma genitalium (M. genitalium)was first isolated from the urethral swabs of two symptomatic men with urethritis in 1980. Published prevalence rates vary greatly between populations studied. A number of urogenital conditions have been ascribed toM. genitalium, which is recognised to cause a sexually transmitted infection. The association of M. genitalium with non-specific urethritis is now well established, but the evidence supporting its role in both male and female infertility remains inconclusive. Laboratory methods are challenging and there is a lack of test standardisation. The recommended treatment of the infection is azithromycin as a single 1 gm dose. However, in recent years macrolide resistance has been observed. More studies are required to establish the clinical importance of M. genitaliumin urogenital conditions, particularly infertility, and to establish the role for screening and treatment in high-risk populations.
authors: School of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia gemma.daley@my.jcu.edu.au.
authors: G M
authors: GM
authors: Daley
authors: School of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia Sexual Health Service, Cairns, QLD, Australia School of Population Health, University of Melbourne, Melbourne, VIC, Australia.
authors: D B
authors: DB
authors: Russell
authors: Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Melbourne, VIC, Australia Department of Molecular Microbiology, Murdoch Children's Research Institute, Melbourne, VIC, Australia Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, VIC, Australia.
authors: S N
authors: SN
authors: Tabrizi
authors: School of Medicine and Dentistry, James Cook University, Cairns, QLD, Australia.
authors: J
authors: J
authors: McBride
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004269:DNA, Bacterial; D005260:Female; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use; D008297:Male; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000382:microbiology*; D045704:Mycoplasma genitalium / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D012749:Sexually Transmitted Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000635:transmission; D014526:Urethritis / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D018942:Macrolides
keywords: Mycoplasma genitalium; diagnosis; prevalence; resistance; screening; sexually transmitted infection; treatment