title: Functional imaging in primary tumour-induced osteomalacia: relative performance of FDG PET/CT vs somatostatin receptor-based functional scans: a series of nine patients.
abstract: BACKGROUND
  Localization of phosphatonin-producing mesenchymal tumours in patients with primary tumour-induced osteomalacia (pTIO) is challenging. Functional imaging plays an important role in the localization of these tumours.
  
  
  OBJECTIVE
  We studied the relative performance of different functional imaging modalities ((18) F-FDG PET/CT, (99) Tc-HYNIC-TOC SPECT/CT and (68) Ga-DOTATATE PET/CT) in tumour localization in cases of pTIO.
  
  
  METHODS
  Retrospective chart evaluation of 16 patients with confirmed TIO treated from 2006 to 2013 was conducted in a tertiary care referral centre.
  
  
  RESULTS
  Of 16, nine patients had pTIO. In these nine, the positivity rates of different functional imaging modalities were 50% for (18) F-FDG PET/CT (four of eight patients), 100% for (99) Tc-HYNIC-TOC SPECT/CT (six of six patients) and 100% for (68) Ga-DOTATATE PET/CT (seven of seven patients). Of nine patients, six were subjected to both the (99) Tc-HYNIC-TOC SPECT/CT and (68) Ga-DOTATATE PET/CT and all of them showed coregistration on the two scans.
  
  
  CONCLUSIONS
  In patients with pTIO, the somatostatin receptor-based functional scans performed better than (18) F-FDG PET/CT in tumour localization. Amongst the somatostatin receptor-based scans, (99) Tc-HYNIC-TOC SPECT/CT and (68) Ga-DOTATATE PET/CT performed equally well for localization of tumours.
authors: Department of Endocrinology, KEM Hospital, Mumbai, India.
authors: Swati
authors: S
authors: Jadhav
authors: Rajeev
authors: R
authors: Kasaliwal
authors: Vikram
authors: V
authors: Lele
authors: Venkatesh
authors: V
authors: Rangarajan
authors: Piyush
authors: P
authors: Chandra
authors: Hina
authors: H
authors: Shah
authors: Gaurav
authors: G
authors: Malhotra
authors: Varsha S
authors: VS
authors: Jagtap
authors: Sweta
authors: S
authors: Budyal
authors: Anurag R
authors: AR
authors: Lila
authors: Tushar
authors: T
authors: Bandgar
authors: Nalini S
authors: NS
authors: Shah
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009372:Neoplasms, Connective Tissue / Q000175:diagnosis* / Q000378:metabolism* / Q000601:surgery; D010018:Osteomalacia; D010257:Paraneoplastic Syndromes; D049268:Positron-Emission Tomography / Q000379:methods*; D017481:Receptors, Somatostatin / Q000378:metabolism*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D017481:Receptors, Somatostatin; D019788:Fluorodeoxyglucose F18