title: Improving CKD therapies and care: a National Dialogue.
abstract: The Kidney Research National Dialogue, supported by the National Institute of Diabetes and Digestive and Kidney Diseases, asked the research and clinical communities to formulate and prioritize research objectives that would improve our understanding of kidney function and diseases. This commentary outlines the high-priority research objectives for CKD. The goal of these research objectives is to enhance knowledge to improve outcomes in people with CKD. Basic and translational research, longitudinal observations, and epidemiologic studies can each point to targets for intervention. Future interventions must be informed by data from well designed, large representative observational studies that include collection of genetic and phenotypic data as well as biospecimens. Interaction of genetic and environmental factors must be part of the analysis, including the influence of diet, comorbid conditions, and medication. The focus should be not only on slowing or preventing progression of CKD, but also on regression of disease to the greatest extent possible.
authors: Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
authors: Frederick
authors: F
authors: Kaskel
authors: Daniel
authors: D
authors: Batlle
authors: Srinivasan
authors: S
authors: Beddhu
authors: John
authors: J
authors: Daugirdas
authors: Harold
authors: H
authors: Feldman
authors: Maria
authors: M
authors: Ferris
authors: Lawrence
authors: L
authors: Fine
authors: Barry I
authors: BI
authors: Freedman
authors: Paul L
authors: PL
authors: Kimmel
authors: Michael F
authors: MF
authors: Flessner
authors: Robert A
authors: RA
authors: Star
mesh_terms: D000818:Animals; D035843:Biomedical Research / Q000458:organization & administration; D006292:Health Priorities; D006801:Humans; D009398:Nephrology / Q000458:organization & administration / Q000592:standards; D009937:Organizational Objectives; D058996:Quality Improvement; D019984:Quality Indicators, Health Care; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D012307:Risk Factors; D016896:Treatment Outcome
keywords: CKD; adolescent; diet; hypertension; pediatric