title: Learning phenotype densities conditional on many interacting predictors.
abstract: BACKGROUND
  Estimating a phenotype distribution conditional on a set of discrete-valued predictors is a commonly encountered task. For example, interest may be in how the density of a quantitative trait varies with single nucleotide polymorphisms and patient characteristics. The subset of important predictors is not usually known in advance. This becomes more challenging with a high-dimensional predictor set when there is the possibility of interaction.
  
  
  RESULTS
  We demonstrate a novel non-parametric Bayes method based on a tensor factorization of predictor-dependent weights for Gaussian kernels. The method uses multistage predictor selection for dimension reduction, providing succinct models for the phenotype distribution. The resulting conditional density morphs flexibly with the selected predictors. In a simulation study and an application to molecular epidemiology data, we demonstrate advantages over commonly used methods.
authors: Advanced Analytics Division, SAS Institute Inc., Cary, NC 27513, Molecular and Genetic Epidemiology Section, Epidemiology Branch and Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 and Department of Statistical Science, Duke University, Durham, NC 27708.
authors: David C
authors: DC
authors: Kessler
authors: Advanced Analytics Division, SAS Institute Inc., Cary, NC 27513, Molecular and Genetic Epidemiology Section, Epidemiology Branch and Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 and Department of Statistical Science, Duke University, Durham, NC 27708.
authors: Jack A
authors: JA
authors: Taylor
authors: Advanced Analytics Division, SAS Institute Inc., Cary, NC 27513, Molecular and Genetic Epidemiology Section, Epidemiology Branch and Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 and Department of Statistical Science, Duke University, Durham, NC 27708.
authors: David B
authors: DB
authors: Dunson
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D006801:Humans; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide