title: Acute organophosphorus poisoning.
abstract: Acute organophosphorus poisoning continues to be a detrimental problem and a potential cause of mortality especially in developing countries. Inhibition of acetylcholinesterase enzyme is the main mechanism of toxicity of such pesticides and measurement of acetylcholinesterase activity is the commonly used laboratory diagnosis approved for the purpose. It is now proved beyond any doubt that early intervention is beneficial for cases of acute organophosphorus poisoning and, therefore, considerable current interest has been generated for development of point of care testing tool for screening of the same. However, to the best of our knowledge so far the matter is not reviewed from the view of point of care testing tool development. In this paper, this subject is reviewed highlighting the methodological aspects and point of care testing tool development in the context of organophosphorus poisoning.
authors: Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India.
authors: Sheemona
authors: S
authors: Chowdhary
authors: Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, India.
authors: Rajasri
authors: R
authors: Bhattacharyya
authors: Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. Electronic address: dibyajyoti5200@yahoo.co.in.
authors: Dibyajyoti
authors: D
authors: Banerjee
mesh_terms: D000208:Acute Disease; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use; D002801:Cholinesterase Reactivators / Q000627:therapeutic use; D006801:Humans; D062025:Organophosphate Poisoning / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*; D010575:Pesticides / Q000506:poisoning
chemical_list: D000931:Antidotes; D002801:Cholinesterase Reactivators; D010575:Pesticides
keywords: Acetylcholinesterase; Acute organophosphorus poisoning; Organocarbamate poisoning; Pesticides; Point of care testing tool