title: Applications of biocatalytic arene ipso,ortho cis-dihydroxylation in synthesis.
abstract: The dearomatising dihydroxylation of aromatic molecules mediated by arene dioxygenase enzymes can provide cyclohexadiene-diols that are versatile starting materials for organic synthesis. Whereas oxidation of a substituted arene to give its ortho,meta-dihydrodiol has been demonstrated for numerous substrates and dioxygenases, formation of ipso,ortho-dihydrodiols has historically been underutilised in comparison. This feature article presents a chronological account of reported uses of such diols.
authors: Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. S.E.Lewis@bath.ac.uk.
authors: Simon E
authors: SE
authors: Lewis
mesh_terms: D055162:Biocatalysis; D061565:Cycloaddition Reaction; D049308:Dioxygenases / Q000737:chemistry* / Q000378:metabolism; D006900:Hydroxylation; D016958:Pseudomonas putida / Q000378:metabolism; D043367:Ralstonia / Q000378:metabolism
chemical_list: D049308:Dioxygenases