title: Urinary tartaric acid as a potential biomarker for the dietary assessment of moderate wine consumption: a randomised controlled trial.
abstract: The availability of biomarkers that allow the estimation of the intake of specific foods and dietary components, as an alternative or addition to self-reported dietary questionnaires, could greatly enhance the effectiveness of nutritional research. The aim of the present study was to assess tartaric acid, one of the major components of red and white wines, as a potential biomarker of wine consumption. A total of twenty-one healthy men participated in a randomised cross-over feeding trial. They consumed a single dose of 100, 200 or 300 ml wine at dinner. Before each intervention, the participants followed a 7 d washout period during which they avoided consuming wine or grape-based products. Morning urine was collected and analysed by liquid chromatography coupled to electrospray ionisation tandem MS. A strong significant correlation was found between wine intake and urinary tartaric acid (r(s) = 0·9220; P <0·001). Using a cut-off value of 8·84 μg/mg creatinine, tartaric acid allowed wine consumers to be differentiated from non-wine consumers. The results suggest that urinary tartaric acid may be a sensitive and specific dietary biomarker of wine consumption.
authors: Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, Ourense Campus, University of Vigo, Ourense 32004, Spain.
authors: Jorge
authors: J
authors: Regueiro
authors: Department of Nutrition and Food Science, XaRTA, INSA, School of Pharmacy, University of Barcelona, Avinguda Joan XXIII s/n, Barcelona 08028, Spain.
authors: Anna
authors: A
authors: Vallverdú-Queralt
authors: Nutrition and Bromatology Group, Analytical and Food Chemistry Department, Faculty of Food Science and Technology, Ourense Campus, University of Vigo, Ourense 32004, Spain.
authors: Jesús
authors: J
authors: Simal-Gándara
authors: Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain.
authors: Ramón
authors: R
authors: Estruch
authors: Department of Nutrition and Food Science, XaRTA, INSA, School of Pharmacy, University of Barcelona, Avinguda Joan XXIII s/n, Barcelona 08028, Spain.
authors: Rosa María
authors: RM
authors: Lamuela-Raventós
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000652:urine*; D000465:Algorithms; D015415:Biomarkers / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000652:urine; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D062407:Meals; D008875:Middle Aged; D015596:Nutrition Assessment; D012372:ROC Curve; D013030:Spain; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry; D013644:Tartrates / Q000652:urine*; D014920:Wine; D055815:Young Adult
chemical_list: D015415:Biomarkers; D013644:Tartrates; D003404:Creatinine; C029768:tartaric acid