title: Magnetic core-shell chitosan nanoparticles: rheological characterization and hyperthermia application.
abstract: Stabilized magnetic nanoparticles are the subject of intense research for targeting applications and this work deals with the design, preparation and application of specific core-shell nanoparticles based on ionic crosslinked chitosan. The nanometric size of the materials was demonstrated by dynamic light scattering (DLS) and field emission scanning electron microscopy (FESEM) that also proved an increase of the size of chitosan nanoparticles (NPs) with the magnetite content. Steady oscillatory rheology measurements revealed a gel-like behavior of aqueous dispersions of chitosan NPs with concentrations ranging from 0.5% to 2.0% (w/v). The cytotoxicity of all the materials synthesized was analyzed in human fibroblasts cultures using the Alamar Blue and lactate dehydrogenase (LDH) assays. The measured specific power absorption under alternating magnetic fields (f = 580 kHz, H = 24 kA/m) indicated that magnetic core-shell chitosan NPs can be useful as remotely driven heaters for magnetic hyperthermia.
authors: Instituto de Ciencia y Tecnología de Polímeros (CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain.
authors: Vanessa
authors: V
authors: Zamora-Mora
authors: Instituto de Ciencia y Tecnología de Polímeros (CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain; CIBER-BBN, Ebro River Campus Building R&D Block 5, Floor 1, Poeta Mariano Esquillor s/n, 50017 Zaragoza, Spain.
authors: Mar
authors: M
authors: Fernández-Gutiérrez
authors: Instituto de Ciencia y Tecnología de Polímeros (CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain; CIBER-BBN, Ebro River Campus Building R&D Block 5, Floor 1, Poeta Mariano Esquillor s/n, 50017 Zaragoza, Spain.
authors: Julio
authors: J
authors: San Román
authors: Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Mariano Esquillor, 50018 Zaragoza, Spain.
authors: Gerardo
authors: G
authors: Goya
authors: Instituto de Ciencia y Tecnología de Polímeros (CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain. Electronic address: rhernandez@ictp.csic.es.
authors: Rebeca
authors: R
authors: Hernández
authors: Instituto de Ciencia y Tecnología de Polímeros (CSIC), c/Juan de la Cierva, 3, 28006 Madrid, Spain.
authors: Carmen
authors: C
authors: Mijangos
mesh_terms: D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D012212:Rheology; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D048271:Chitosan
keywords: Chitosan; Core–shell nanoparticles; Magnetic hyperthermia; Sodium tripolyphosphate