title: Nanozeolite-LTL with Gd(III) deposited in the large and Eu(III) in the small cavities as a magnetic resonance optical imaging probe.
abstract: The immense structural diversity of more than 200 known zeolites is the basis for the wide variety of applications of these fascinating materials ranging from catalysis and molecular filtration to agricultural uses. Despite this versatility, the potential of zeolites in medical imaging has not yet been much exploited. In this work a novel strategy is presented to selectively deposit different ions into distinct framework locations of zeolite-LTL (Linde type L) and it is demonstrated that the carefully ion-exchanged Gd/Eu-containing nanocrystals acquire exceptional magnetic properties in combination with enhanced luminescence. This smart exploitation of the framework structure yields the highest relaxivity density (13.7 s(-1)  L g(-1) at 60 MHz and 25 °C) reported so far for alumosilicates, rendering these materials promising candidates for the design of dual magnetic resonance/optical imaging probes, as demonstrated in preliminary phantom studies.
authors: Department of Biotechnology, Delft University of Technology, Julianalaan 136, 2628 BL Delft (The Netherlands), Fax: (+31) 152781415.
authors: Florian
authors: F
authors: Mayer
authors: Wuyuan
authors: W
authors: Zhang
authors: Thomas
authors: T
authors: Brichart
authors: Olivier
authors: O
authors: Tillement
authors: Célia S
authors: CS
authors: Bonnet
authors: Éva
authors: É
authors: Tóth
authors: Joop A
authors: JA
authors: Peters
authors: Kristina
authors: K
authors: Djanashvili
mesh_terms: D002384:Catalysis; D003287:Contrast Media / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D005682:Gadolinium / Q000737:chemistry*; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D049329:Nanostructures / Q000737:chemistry*; D017641:Zeolites / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D017641:Zeolites; D005063:Europium; D005682:Gadolinium
keywords: bimodal imaging; ion relocation; lanthanides; luminescence; relaxivity; zeolites