title: Birth weight and preterm birth in babies of pregnant women with major depression in relation to treatment with antidepressants.
abstract: OBJECTIVE
  It is unclear whether antidepressant treatment has a preventive effect on negative neonatal outcomes due to major depression in pregnant women. The objective of the present study was to compare women with major depression treated with antidepressants, untreated women with major depression, and healthy women during pregnancy with respect to birth weight and preterm birth.
  
  
  METHODS
  The study sample included a total of 23 women taking antidepressant medication, 36 women who were not taking antidepressant medication for major depression during pregnancy, and 30 healthy women. Major depression was diagnosed via the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition.
  
  
  RESULTS
  The study groups were similar with respect to sociodemographic characteristics. Compared with infants of healthy control subjects, infants of untreated major depressed women had significantly lower birth weight and shorter gestational age at delivery. There is no significant difference between infants of major depressed women treated with antidepressants and infants of healthy subjects for these variables.
  
  
  CONCLUSIONS
  Our results suggest that antidepressants may have beneficial effects on the risk of low birth weight and preterm birth in the infants of depressed women.
authors: From the *Department of Psychiatry, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya; †Department of Psychiatry, Bakirkoy Research and Training Hospital, Istanbul; and Departments of ‡Psychiatry and §Neonatology, University of Selcuk, Faculty of Medicine, Konya, Turkey.
authors: Mine
authors: M
authors: Şahingöz
authors: Goksen
authors: G
authors: Yuksel
authors: Cagatay
authors: C
authors: Karsidag
authors: Faruk
authors: F
authors: Uguz
authors: Erdem Onder
authors: EO
authors: Sonmez
authors: Bilge Burcak
authors: BB
authors: Annagur
authors: Ali
authors: A
authors: Annagur
mesh_terms: D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001724:Birth Weight / Q000187:drug effects*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D047928:Premature Birth / Q000517:prevention & control*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors