title: Early dynamics of leptin plasma level in surgical critically ill patients. a prospective comparative study.
abstract: BACKGROUND
  Leptin (LPT), a hormone secreted by adipocytes,plays a role in inflammation and infection. Our study aimed to characterize the early dynamics of LPT in comparison with CRP and IL-6 during systemic inflammatory response syndrome(SIRS) and sepsis in surgical patients.
  
  
  METHODS
  Sixty patients were assigned into 3 equal groups:SIRS (SI) group with major abdominal elective surgery;sepsis (SE) group with community-acquired complicated intra-abdominal infection and controls (C). LPT, CRP and IL-6 were measured initially in all groups and repeated in groups SI and SE within 5 days after surgery (9 samples - 4 day 1, 2 day 2, 1 next 3 days).
  
  
  RESULTS
  LPT increased at 12-24 hours in SI group, but stayed within normal range in SE group. CRP and IL-6 had higher values in SE group versus SI group with an early peak for IL-6 and a late peak for CRP.
  
  
  CONCLUSIONS
  LPT has a different early dynamics during SIRS and sepsis. LPT measurement in association with CRP or IL-6 may be useful in the differential diagnosis and prognosis of surgical critical illness at different time courses.
authors: I
authors: I
authors: Grigoraş
authors: D D
authors: DD
authors: Branisteanu
authors: D
authors: D
authors: Ungureanu
authors: D
authors: D
authors: Rusu
authors: I
authors: I
authors: Ristescu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D016638:Critical Illness; D003937:Diagnosis, Differential; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D059413:Intraabdominal Infections / Q000097:blood* / Q000175:diagnosis / Q000601:surgery; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D020738:Leptin; D002097:C-Reactive Protein