title: Supramolecular polymeric peptide amphiphile vesicles for the encapsulation of basic fibroblast growth factor.
abstract: The synthesis of a supramolecular double hydrophilic peptide-conjugated polymer held together by cucurbit[8]uril (CB[8]) ternary complexation and its subsequent temperature triggered self-assembly into vesicles are described. Basic fibroblast growth factor can be easily loaded into the vesicles under benign conditions and their bioactivities can be preserved without the need for excipients such as heparin.
authors: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. oas23@cam.ac.uk.
authors: Xian Jun
authors: XJ
authors: Loh
authors: Jesús
authors: J
authors: del Barrio
authors: Tung-Chun
authors: TC
authors: Lee
authors: Oren A
authors: OA
authors: Scherman
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage* / Q000494:pharmacology; D007093:Imidazoles / Q000737:chemistry*; D051379:Mice; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils
chemical_list: D001952:Bridged-Ring Compounds; D004337:Drug Carriers; D016222:Fibroblast Growth Factor 2; D007093:Imidazoles; D010455:Peptides; D011108:Polymers; D013501:Surface-Active Agents; C507198:cucurbit(8)uril; D047028:Macrocyclic Compounds; D000099246:Cucurbit(n)urils