title: Palladium-catalyzed α-arylation of benzylic phosphonates.
abstract: A new synthetic route to access diarylmethyl phosphonates is presented. The transformation enables the introduction of aromatic groups on benzylic phosphonates via a deprotonative cross-coupling process (DCCP). The Pd(OAc)2/CataCXium A-based catalyst afforded a reaction between benzyl diisopropyl phosphonate derivatives and aryl bromides in good to excellent isolated yields (64-92%).
authors: Roy and Diana Vagelos Laboratories, Penn/Merck Laboratory for High-Throughput Experimentation, University of Pennsylvania , Department of Chemistry, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
authors: Sonia
authors: S
authors: Montel
authors: Ludovic
authors: L
authors: Raffier
authors: Yuying
authors: Y
authors: He
authors: Patrick J
authors: PJ
authors: Walsh
mesh_terms: D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D006842:Hydrocarbons, Brominated; D063065:Organophosphonates; D010165:Palladium