title: Predictive parameters of accelerated muscle loss in men-MINOS study.
abstract: BACKGROUND
  Aging-related muscle loss is a public health problem. We investigated the association of lifestyle and hormonal factors with a prospectively assessed muscle loss in older men.
  
  
  METHODS
  Among 608 home-dwelling men, aged 60-85 (mean 68) years, lifestyle and health status were evaluated through a questionnaire. Appendicular skeletal muscle mass was estimated using dual-energy x-ray absorptiometry and calculated as the sum of lean mass of the 4 limbs. Free testosterone concentration was calculated using concentrations of total testosterone and sex hormone-binding globulin. Longitudinal data were analyzed by hierarchical models.
  
  
  RESULTS
  Average muscle loss was 0.63 ± 0.05%/year. The results of our multivariable adjusted analyses showed that muscle loss was higher in men whose leisure physical activity was <15 hours/week versus ≥15 hours/week (-0.76 vs -0.57%/year). Age-related acceleration of muscle loss was greater in men with lower total testosterone levels (<10 vs ≥10 nmol/L: -0.10 vs -0.07%/year/year of age at baseline [age]). Men with lower free testosterone (<75 vs ≥75 pmol/L) had greater age-related acceleration of muscle loss (-0.12 vs -0.08%/year/age). Higher parathyroid hormone concentrations were associated with greater age-related acceleration of muscle loss (≥45 vs <45 pg/mL -0.14 vs -0.12%/year/age). Men with type 2 diabetes had higher age-related acceleration of muscle loss versus men without diabetes (-0.08 vs -0.03%/year/age) (All P values are <.05).
  
  
  CONCLUSIONS
  In elderly men, low leisure physical activity, type 2 diabetes, low total and free testosterone, and elevated parathyroid hormone concentrations are associated with greater age-related acceleration of muscle loss. These factors are likely to represent real determinants of aging-related muscle loss in men.
authors: Institut National de la Santé et de la Recherche Médicale (INSERM) Unit 1033, University of Lyon, Lyon, France.
authors: Alexia
authors: A
authors: Renoud
authors: Department of Biostatistics, University of Lyon, UMR CNRS 5558, Lyon, France.
authors: René
authors: R
authors: Ecochard
authors: Société de Secours Minière de Bourgogne, Montceau les Mines, France.
authors: François
authors: F
authors: Marchand
authors: Institut National de la Santé et de la Recherche Médicale (INSERM) Unit 1033, University of Lyon, Lyon, France.
authors: Roland
authors: R
authors: Chapurlat
authors: Institut National de la Santé et de la Recherche Médicale (INSERM) Unit 1033, University of Lyon, Lyon, France. Electronic address: pawel.szulc@inserm.fr.
authors: Pawel
authors: P
authors: Szulc
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009135:Muscular Diseases / Q000209:etiology* / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood
chemical_list: D015415:Biomarkers; D010281:Parathyroid Hormone; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone
keywords: Aging; Men; Muscle mass; Type 2 diabetes mellitus