title: Saffron in metabolic syndrome: its effects on antibody titers to heat-shock proteins 27, 60, 65 and 70.
abstract: BACKGROUND
  The metabolic syndrome is the most important risk factor for cardiovascular disease. The heat shock proteins (HSPs) are highly conserved families of proteins expressed by a number of cell types following exposure to stressful environmental conditions include several known risk factors for cardiovascular disease. Recent studies have shown the potential of constituents of saffron in the treatment of atherosclerosis. We aimed on investigating the effect of saffron on antibody titers to HSP in patients with metabolic syndrome.
  
  
  METHODS
  This was a randomized, placebo-controlled clinical trial. One-hundred and five subjects with metabolic syndrome were randomly allocated to one of the three groups: the case group received 100 mg/day saffron, the placebo control group received a capsule of placebo and a non-placebo control group received no capsule, for 12 weeks.
  
  
  RESULTS
  Antibodies against heat shock proteins 27, 60, 65 and 70 were determined in all patients before (week 0) and after (week 6 and 12) intervention. At 12 weeks, saffron produced a significantly decrease in AntiHSP27, 70 levels. Saffron can decrease AntiHSP27, 70 levels in patients with metabolic syndrome.
  
  
  CONCLUSIONS
  The results of this study indicate the efficacy of saffron in the improvement of some markers of autoimmunity HSPs in patients with metabolic syndrome.
authors: Maryam
authors: M
authors: Shemshian
authors: Seyed Hadi
authors: SH
authors: Mousavi
authors: Abdolreza
authors: A
authors: Norouzy
authors: Tayebe
authors: T
authors: Kermani
authors: Toktam
authors: T
authors: Moghiman
authors: Akram
authors: A
authors: Sadeghi
authors: Majid
authors: M
authors: Ghayour-Mobarhan
authors: Gordon A
authors: GA
authors: Ferns
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000906:Antibodies / Q000187:drug effects / Q000378:metabolism; D002214:Capsules; D027622:Crocus; D004311:Double-Blind Method; D005260:Female; D006360:Heat-Shock Proteins / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy*; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use*; D055105:Waist Circumference / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects; D055815:Young Adult
chemical_list: D000906:Antibodies; D002214:Capsules; D006360:Heat-Shock Proteins; D010936:Plant Extracts