title: Protective effects of polysaccharides from Lilium lancifolium on streptozotocin-induced diabetic mice.
abstract: In this study, the protective effect of Lilium lancifolium polysaccharides (LLP) on streptozotocin (STZ)-induced diabetic mice and possible mechanism were investigated. The diabetic mice were administered with LLP for 28 days. The results showed that oral administration of LLP could significantly decrease blood glucose level and increase body weight loss in STZ-induced diabetic mice. LLP also significantly increased the activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) and decreased the level of malondialdehyde (MDA) in serum, liver, and kidney in STZ-induced diabetic mice. Moreover, histopathological examination showed that LLP could markedly improve the structure integrity of pancreatic islet tissue in STZ-induced diabetic mice. However, LLP had no significant effect on organ weight of liver and pancreas of diabetic mice, but significantly decreased kidney weight compared with diabetic control mice. This study suggested that LLP had hypoglycemic and antioxidant properties and could provide protective effect on STZ-induced diabetic mice.
authors: School of Biotechnology and Food Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, PR China.
authors: Ting
authors: T
authors: Zhang
authors: School of Biotechnology and Food Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, PR China.
authors: Jie
authors: J
authors: Gao
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, PR China.
authors: Zheng-Yu
authors: ZY
authors: Jin
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 Lihu Road, Wuxi, Jiangsu 214122, PR China.
authors: Xue-Ming
authors: XM
authors: Xu
authors: School of Biotechnology and Food Engineering, Hefei University of Technology, 193 Tunxi Road, Hefei, Anhui 230009, PR China. Electronic address: hanqchen@hfut.edu.cn.
authors: Han-Qing
authors: HQ
authors: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D027762:Lilium / Q000737:chemistry*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D011134:Polysaccharides / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D011134:Polysaccharides; D008315:Malondialdehyde
keywords: Diabetes mellitus; Lilium lancifolium; Polysaccharide