title: Anticonvulsant potential of certain new (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides.
abstract: Anticonvulsant potential and neurotoxicity of certain new imidazole-containing arylsemicarbazones 6a-p are reported. The test compounds 6a-p exhibited anticonvulsant activity mainly in the scPTZ screen. Compound 6p emerged as the most active surrogate displaying 100% protection at a dose level of 636 μ mol/kg in the scPTZ screen without any neurotoxicity. The assigned (E)-configuration of the title compounds 6a-p was confirmed via single crystal X-ray structure of compound 6g.
authors: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia ; Pharmaceutical and Drug Industries Research Division, Medicinal and Pharmaceutical Chemistry Department (Medicinal Chemistry Group), National Research Centre, Dokki, Giza 12622, Egypt.
authors: Mohamed I
authors: MI
authors: Attia
authors: Pharmaceutical and Drug Industries Research Division, Medicinal and Pharmaceutical Chemistry Department (Medicinal Chemistry Group), National Research Centre, Dokki, Giza 12622, Egypt.
authors: Mohamed N
authors: MN
authors: Aboul-Enein
authors: Pharmaceutical and Drug Industries Research Division, Medicinal and Pharmaceutical Chemistry Department (Medicinal Chemistry Group), National Research Centre, Dokki, Giza 12622, Egypt.
authors: Aida A
authors: AA
authors: El-Azzouny
authors: Pharmaceutical and Drug Industries Research Division, Medicinal and Pharmaceutical Chemistry Department (Pharmacology Group), National Research Centre, Dokki, Giza 12622, Egypt.
authors: Yousreya A
authors: YA
authors: Maklad
authors: Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors: Hazem A
authors: HA
authors: Ghabbour
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D014116:Toxicology
chemical_list: D000927:Anticonvulsants; D006834:Hydrazines; D007093:Imidazoles; C029899:imidazole