title: New roles for the BLyS/BAFF family in antigen-experienced B cell niches.
abstract: BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity maturation in germinal centers, which lie at the intersection of the pre-immune and antigen-experienced B cell compartments. We propose a model whereby tolerogenic selection at the transitional stage and affinity maturation in the germinal center employ the same BLyS driven mechanism.
authors: AbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, United States. Electronic address: radhika.goenka@abbvie.com.
authors: Radhika
authors: R
authors: Goenka
authors: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, United States. Electronic address: jeanl@mail.med.upenn.edu.
authors: Jean L
authors: JL
authors: Scholz
authors: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, United States. Electronic address: sindhava@mail.med.upenn.edu.
authors: Vishal J
authors: VJ
authors: Sindhava
authors: Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, United States. Electronic address: cancro@mail.med.upenn.edu.
authors: Michael P
authors: MP
authors: Cancro
mesh_terms: D017951:Antigen Presentation / Q000276:immunology*; D053264:B-Cell Activating Factor / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D002470:Cell Survival / Q000276:immunology; D018858:Germinal Center / Q000276:immunology; D006801:Humans; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000276:immunology
chemical_list: D053264:B-Cell Activating Factor; C505719:TNFSF13B protein, human; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13
keywords: BAFF; BLyS; Germinal center; TACI