title: Microwave-assisted synthesis of glycopolymer-functionalized silver nanoclusters: combining the bioactivity of sugar with the fluorescence and cytotoxicity of silver.
abstract: Copolymers of 2-(methacrylamido)glucopyranose (MAG) and methacrylic acid (MAA) are synthesized by RAFT polymerization and then used as templates to prepare glycopolymer-functionalized Ag nanoclusters (Gly-Ag NCs) through microwave irradiation. Polymers and the resulting nanoclusters are characterized by NMR, GPC, UV-Vis, SEM, TEM, AAS and fluorescence spectroscopy. The bio-activity of the fluorescent Gly-Ag NCs are further examined using GLUT-1 over-expressing cancer cells K562. Gly-Ag NCs show efficient binding ability toward K562 cells and inhibit the cell viability in a dose dependent manner (IC50 = 0.65 μg mL(-1)), indicating their potential biological applications for both cancer imaging and targeted cancer therapy.
authors: Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou, 215006, PR China; College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, PR China.
authors: Wei
authors: W
authors: Lu
authors: Wenjuan
authors: W
authors: Ma
authors: Jiawei
authors: J
authors: Lu
authors: Xiao
authors: X
authors: Li
authors: Yun
authors: Y
authors: Zhao
authors: Gaojian
authors: G
authors: Chen
mesh_terms: D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005453:Fluorescence; D006801:Humans; D020128:Inhibitory Concentration 50; D020014:K562 Cells; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000506:poisoning / Q000648:ultrastructure; D008689:Methacrylates / Q000737:chemistry; D008854:Microscopy, Electron; D008872:Microwaves; D008956:Models, Chemical; D015394:Molecular Structure; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D013050:Spectrometry, Fluorescence
chemical_list: D002241:Carbohydrates; D008689:Methacrylates; D011108:Polymers; C008384:methacrylic acid; D012834:Silver
keywords: glycopolymers; imaging; microwave irradiation; reversible addition fragmentation chain transfer (RAFT); silver nanoclusters