title: Electrospun antibacterial polyurethane-cellulose acetate-zein composite mats for wound dressing.
abstract: In this study, an antibacterial electrospun nanofibrous scaffolds with diameters around 400-700 nm were prepared by physically blending polyurethane (PU) with two biopolymers such as cellulose acetate (CA) and zein. Here, PU was used as the foundation polymer, was blended with CA and zein to achieve desirable properties such as better hydrophilicity, excellent cell attachment, proliferation and blood clotting ability. To prevent common clinical infections, an antimicrobial agent, streptomycin sulfate was incorporated into the electrospun fibers and its antimicrobial ability against the gram negative and gram positive bacteria were examined. The interaction between fibroblasts and the PU-CA and PU-CA-zein-drug scaffolds such as viability, proliferation, and attachment were characterized. PU-CA-zein-drug composite nanoscaffold showed enhanced blood clotting ability in comparison with pristine PU nanofibers. The presence of CA and zein in the nanofiber membrane improved its hydrophilicity, bioactivity and created a moist environment for the wound, which can accelerate wound recovery.
authors: Bionano Systems Engineering Department, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address: afeesh@jbnu.ac.kr.
authors: Afeesh Rajan
authors: AR
authors: Unnithan
authors: Department of Molecular Medicine Clinical Vaccine R&D Center, Chonnam National University, Hwasun, South Korea.
authors: Gopalsamy
authors: G
authors: Gnanasekaran
authors: College of Agriculture and Life Sciences, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors: Yesupatham
authors: Y
authors: Sathishkumar
authors: College of Agriculture and Life Sciences, Chonbuk National University, Jeonju 561-756, Republic of Korea.
authors: Yang Soo
authors: YS
authors: Lee
authors: Bionano Systems Engineering Department, Chonbuk National University, Jeonju 561-756, Republic of Korea. Electronic address: chskim@jbnu.ac.kr.
authors: Cheol Sang
authors: CS
authors: Kim
mesh_terms: D041721:3T3-L1 Cells; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use; D001458:Bandages; D001777:Blood Coagulation / Q000187:drug effects; D002482:Cellulose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D015539:Platelet Activation / Q000187:drug effects; D011140:Polyurethanes / Q000008:administration & dosage*; D014947:Wounds and Injuries / Q000628:therapy*; D015028:Zein / Q000008:administration & dosage*
chemical_list: D000900:Anti-Bacterial Agents; D011140:Polyurethanes; C005062:acetylcellulose; D002482:Cellulose; D015028:Zein
keywords: Antibacterial; Electrospinning; Nanofiber; Tissue engineering; Wound dressing; Zein