title: Are increased levels of systemic oxidative stress and inflammation associated with age-related cataract?
abstract: Oxidative stress and inflammation may be involved in the etiology of age-related cataract. This study is the first to investigate the association between urinary levels of 8-iso-prostaglandin F₂α (PGF₂α; as a biomarker for systemic oxidative stress in vivo) and 15-keto-dihydro-PGF₂α (as a biomarker for systemic inflammation in vivo) and risk of age-related cataract. We observed in a nested case-control study, including 258 women with incident cataract diagnosis and/or cataract extraction and 258 women without cataract, matched on age and date of urine sample collection that, women with higher levels of urinary 8-iso-PGF₂α as compared with lower levels had an increased risk of age-related cataract. There was no difference in 15-keto-dihydro-PGF₂α levels between cases and controls. Our observations lead to the hypothesis that higher systemic oxidative stress increases the risk of developing age-related cataract.
authors: 1 Division of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet , Stockholm, Sweden .
authors: Jinjin Zheng
authors: JZ
authors: Selin
authors: Birgitta Ejdervik
authors: BE
authors: Lindblad
authors: Susanne
authors: S
authors: Rautiainen
authors: Karl
authors: K
authors: Michaëlsson
authors: Ralf
authors: R
authors: Morgenstern
authors: Matteo
authors: M
authors: Bottai
authors: Samar
authors: S
authors: Basu
authors: Alicja
authors: A
authors: Wolk
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000473:pathology*; D016022:Case-Control Studies; D002386:Cataract / Q000378:metabolism* / Q000473:pathology / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D018384:Oxidative Stress
chemical_list: C008228:15-keto-13,14-dihydroprostaglandin F2alpha; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost