title: A miR-SNP of the KRT81 gene is associated with the prognosis of non-Hodgkin's lymphoma.
abstract: MicroRNA (miRNA), which plays an important role in tumorigenesis, can regulate post-transcriptional gene expression by binding to the 3' untranslated regions (3'-UTRs) of messenger RNAs and repressing its translation. Several single nucleotide polymorphisms (SNPs) are considered to have significant impacts on susceptibility of the role these genetic polymorphisms in development of carcinogenesis through that mechanism. But few of them focus their impact on non-Hodgkin's lymphoma (NHL). Therefore, we conducted this study to investigate the associations between the genetic variants and cancer risk or cancer outcome. MiRNA-related single nucleotide polymorphism (miR-SNP) sites rs3660 of KRT81, rs1044129 of RYR3, rs4901706 of f101, and rs1053667 of KIAA0423 were selected and analyzed in 210 patients in NHL to evaluate their association with cancer risk and prognosis. The results indicated that none of them is associated with the cancer risk in NHL. Otherwise KRT81 rs3660 GG type is associated with a shorter survival time (p=0.012), after being assessed by multivariate Cox analyses, its effect on prognosis was verified (p=0.003). It suggests that KRT81 rs3660 GG type is an independent prognostic marker in NHL.
authors: Hebei Key Lab of Laboratory Animal Science, Department of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, PR China.
authors: Ying
authors: Y
authors: Xie
authors: Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, PR China.
authors: Lanping
authors: L
authors: Diao
authors: Hebei Key Lab of Laboratory Animal Science, Department of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, PR China.
authors: Li
authors: L
authors: Zhang
authors: Hebei Key Lab of Laboratory Animal Science, Department of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, PR China.
authors: Chao
authors: C
authors: Liu
authors: Hebei Key Lab of Laboratory Animal Science, Department of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, PR China.
authors: Zengnian
authors: Z
authors: Xu
authors: Hebei Key Lab of Laboratory Animal Science, Department of Laboratory Animal Science, Hebei Medical University, Shijiazhuang, PR China. Electronic address: liushf@126.com.
authors: Shufeng
authors: S
authors: Liu
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000097:blood / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D053564:Keratins, Hair-Specific / Q000097:blood / Q000235:genetics*; D053531:Keratins, Type II / Q000097:blood / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D015996:Survival Rate
chemical_list: D020413:3' Untranslated Regions; D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C507600:KRT81 protein, human; D053564:Keratins, Hair-Specific; D053531:Keratins, Type II; D035683:MicroRNAs
keywords: KRT81; NHL; Prognosis; miR-SNPs; rs3660