title: Physicochemical characterization of amphiphilic nanoparticles based on the novel starch-deoxycholic acid conjugates and self-aggregates.
abstract: Novel amphiphilic polymers (starch-deoxycholic acid, St-DCA) were firstly synthesized on the basis of starch (St) as a hydrophilic segment and deoxycholic acid (DCA) as a hydrophobic segment. Hydrophobically modified starch contained 5.4-8.9 deoxycholic acid groups per 100 anhydroglucose units of starch. Self-aggregates of St-DCA conjugates were formed in the PBS media. Physicochemical characterizations of St-DCA conjugates were investigated. The mean sizes of self-aggregates decreased with the degree of substitution (DS) and pH increasing. Zeta potential indicated that nanoparticles were covered with negatively charged starch shells from -5.4 to -23 mV. TEM images demonstrated that nanoparticles were of spherical shape. The critical aggregation concentrations (cac) were dependent on the DS and pH in the range of 0.0185-0.0441 mg/mL. Thus, the study suggested that self-aggregated nanoparticles of St-DCA conjugates could have good pH-responsive and potential application in pharmaceutical and biomedical fields as the delivery of anti-tumor drugs.
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors: Jinlong
authors: J
authors: Yang
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors: Chunmei
authors: C
authors: Gao
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors: Shaoyu
authors: S
authors: Lü
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors: Xinjie
authors: X
authors: Zhang
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors: Chuanming
authors: C
authors: Yu
authors: Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, State Key Laboratory of Applied Organic Chemistry and Department of Chemistry, Lanzhou University, Lanzhou 730000, PR China. Electronic address: mzliu@lzu.edu.cn.
authors: Mingzhu
authors: M
authors: Liu
mesh_terms: D003840:Deoxycholic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D017550:Spectroscopy, Fourier Transform Infrared; D013213:Starch / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D003840:Deoxycholic Acid; D013213:Starch
keywords: Deoxycholic acid; Nanoparticles; Self-aggregates; Starch