title: Effects of polylactic acid film on middle ear mucosa and cochlear function in Guinea pigs.
abstract: Our aim was to assess the effects of polylactic acid (PLA) on middle ear mucosa and cochlea, to be used as a film barrier for postoperative adhesion prevention in the middle ear. Twenty-one albino Guinea pigs were included in the study. A window was opened on both tympanic bulla and on one side PLA material was placed in the middle ear and on the other side only fenestration was performed and used as a control. All Guinea pigs underwent evaluation of tympanic membranes microscopically; functional hearing was analyzed by auditory brainstem responses preoperatively, in the first and the sixth month. All Guinea pigs were killed on the sixth month for histopathologic evaluation of their temporal bones. There was no statistical difference between both groups regarding hearing thresholds, interpeak wave latencies preoperatively and on first and the sixth months postoperatively. Histopathological evaluation revealed no specific changes. There was a mild local inflammation both in the PLA implanted and control ears. PLA film barrier most likely has no toxic effects on Guinea pig middle ear and does not show any ototoxic side effects.
authors: Department of Otolaryngology, Antalya Atatürk Education and Research Hospital, Antalya, Turkey.
authors: Nuray
authors: N
authors: Ensari
authors: Hakan
authors: H
authors: Tutar
authors: Ozgur
authors: O
authors: Ekinci
authors: Mehmet Birol
authors: MB
authors: Ugur
authors: Yıldırım A
authors: YA
authors: Bayazıt
authors: Cagil
authors: C
authors: Gokdogan
authors: Nebil
authors: N
authors: Goksu
mesh_terms: D000818:Animals; D003051:Cochlea / Q000187:drug effects* / Q000503:physiopathology; D004432:Ear, Middle / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D006168:Guinea Pigs; D019344:Lactic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008567:Membranes, Artificial; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D010033:Otitis Media / Q000601:surgery; D011091:Polyesters; D011108:Polymers / Q000009:adverse effects* / Q000627:therapeutic use; D011897:Random Allocation; D000267:Tissue Adhesions / Q000517:prevention & control*; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000187:drug effects / Q000503:physiopathology
chemical_list: D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)