title: Diffuse X-ray scattering to model protein motions.
abstract: Problems in biology increasingly need models of protein flexibility to understand and control protein function. At the same time, as they improve, crystallographic methods are marching closer to the limits of what can be learned from Bragg data in isolation. It is thus inevitable that mainstream protein crystallography will turn to diffuse scattering to model protein motions and improve crystallographic models. The time is ripe to make it happen.
authors: Computer, Computational, and Statistical Sciences Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Electronic address: mewall@lanl.gov.
authors: Michael E
authors: ME
authors: Wall
authors: Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA; Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
authors: Paul D
authors: PD
authors: Adams
authors: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA 94143, USA.
authors: James S
authors: JS
authors: Fraser
authors: Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
authors: Nicholas K
authors: NK
authors: Sauter
mesh_terms: D002140:California; D018360:Crystallography, X-Ray / Q000379:methods; D056004:Molecular Dynamics Simulation; D009038:Motion; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D012542:Scattering, Radiation; D014965:X-Rays
chemical_list: D011506:Proteins