title: Abnormal white matter integrity in the corpus callosum among smokers: tract-based spatial statistics.
abstract: In the present study, we aimed to investigate the difference in white matter between smokers and nonsmokers. In addition, we examined relationships between white matter integrity and nicotine dependence parameters in smoking subjects. Nineteen male smokers were enrolled in this study. Eighteen age-matched non-smokers with no current or past psychiatric history were included as controls. Diffusion tensor imaging scans were performed, and the analysis was conducted using a tract-based special statistics approach. Compared with nonsmokers, smokers exhibited a significant decrease in fractional anisotropy (FA) throughout the whole corpus callosum. There were no significant differences in radial diffusivity or axial diffusivity between the two groups. There was a significant negative correlation between FA in the whole corpus callosum and the amount of tobacco use (cigarettes/day; R = - 0.580, p = 0.023). These results suggest that the corpus callosum may be one of the key areas influenced by chronic smoking.
authors: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Wakako
authors: W
authors: Umene-Nakano
authors: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Reiji
authors: R
authors: Yoshimura
authors: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Shingo
authors: S
authors: Kakeda
authors: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Keita
authors: K
authors: Watanabe
authors: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Kenji
authors: K
authors: Hayashi
authors: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Joji
authors: J
authors: Nishimura
authors: Department of Psychiatry, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors: Hidehiko
authors: H
authors: Takahashi
authors: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Junji
authors: J
authors: Moriya
authors: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Satoru
authors: S
authors: Ide
authors: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Issei
authors: I
authors: Ueda
authors: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Hikaru
authors: H
authors: Hori
authors: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Atsuko
authors: A
authors: Ikenouchi-Sugita
authors: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Asuka
authors: A
authors: Katsuki
authors: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Kiyokazu
authors: K
authors: Atake
authors: Department of Radiology, School of Medicine, Nihon University, Tokyo, Japan.
authors: Osamu
authors: O
authors: Abe
authors: Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Yukunori
authors: Y
authors: Korogi
authors: Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors: Jun
authors: J
authors: Nakamura
mesh_terms: D000328:Adult; D016880:Anisotropy; D003337:Corpus Callosum / Q000503:physiopathology*; D056324:Diffusion Tensor Imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000502:physiology*; D012907:Smoking / Q000503:physiopathology*; D066127:White Matter / Q000503:physiopathology*