title: Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegeneration.
abstract: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor deficits accompanying degeneration of substantia nigra pars compactor (SNc) neurons. Although familial forms of the disease exist, the cause of sporadic PD is unknown. Symptomatic treatments are available for PD, but there are no disease modifying therapies. While the neurodegenerative processes in PD may be multifactorial, this paper will review the evidence that prooxidant iron elevation in the SNc is an invariable feature of sporadic and familial PD forms, participates in the disease mechanism, and presents as a tractable target for a disease modifying therapy.
authors: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building at Genetics Lane on Royal Parade, Parkville, VIC 3010, Australia.
authors: Scott
authors: 0000-0002-3479-2427
authors: S
authors: Ayton
authors: The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Kenneth Myer Building at Genetics Lane on Royal Parade, Parkville, VIC 3010, Australia.
authors: Peng
authors: 0000-0001-5652-1962
authors: P
authors: Lei
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D006801:Humans; D007501:Iron / Q000032:analysis / Q000378:metabolism; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism / Q000503:physiopathology; D013378:Substantia Nigra / Q000737:chemistry / Q000166:cytology / Q000378:metabolism / Q000503:physiopathology; D055815:Young Adult
chemical_list: D007501:Iron