title: Intravascular ultrasound analysis to determine the relationship between high-density lipoprotein cholesterol and lesion characteristics in patients with coronary artery disease.
abstract: OBJECTIVE
  This study utilized grayscale intravascular ultrasound (IVUS) to explore the relationship between high-density lipoprotein cholesterol (HDL-C) levels and culprit lesion characteristics in patients with coronary artery disease.
  
  
  BACKGROUND
  Low HDL-C is associated with an increased risk of cardiovascular events. Previous IVUS studies have suggested a significant association between lesion characteristics and cardiovascular events.
  
  
  METHODS
  According to HDL-C levels, 120 patients who underwent IVUS for native, de novo coronary lesions before any intervention were divided into a low HDL-C group (<40 mg/dL, n = 60) and a high HDL-C group (≥40 mg/dL, n = 60). Quantitative and qualitative IVUS analyses were performed to compare lesion characteristics.
  
  
  RESULTS
  Quantitative IVUS measurements showed no significant differences between the 2 groups. HDL-C level was not significantly correlated with remodeling index (r = 0.03, P = 0.78). However, attenuated plaque was more frequent in the low HDL-C group (48.3% vs. 28.3%, P = 0.02) and a greater percentage of attenuated plaque was found in this group (32.5 ± 21.3% vs. 21.0 ± 11.0%, P = 0.02). Moreover, when categorized into 4 groups according to HDL-C levels, the proportion of attenuated plaque (64.7% in group with <30 mg/dL, 41.9% in group with 30-39 mg/dL, 36.4% in group with 40-59 mg/dL, and 6.3% in group with ≥60 mg/dL; P = 0.001 for trend) was significantly different among groups. On multivariate analysis, only HDL-C and male gender were independently associated with the presence of attenuated plaque at the culprit lesions.
  
  
  CONCLUSIONS
  Patients with low levels of HDL-C may be at increased risk of having a higher incidence of attenuated plaques.
authors: Division of Cardiology, MedStar Washington Hospital Center, Washington, District of Columbia.
authors: Hironori
authors: H
authors: Kitabata
authors: Joshua P
authors: JP
authors: Loh
authors: Lakshmana K
authors: LK
authors: Pendyala
authors: Alfazir
authors: A
authors: Omar
authors: Marco A
authors: MA
authors: Magalhaes
authors: Rebecca
authors: R
authors: Torguson
authors: Fang
authors: F
authors: Chen
authors: Augusto D
authors: AD
authors: Pichard
authors: H Bryan
authors: HB
authors: Brewer
authors: Ron
authors: R
authors: Waksman
mesh_terms: D000368:Aged; D008076:Cholesterol, HDL / Q000378:metabolism*; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention / Q000379:methods*; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging / Q000473:pathology; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods; D018570:Risk Assessment; D013223:Statistics as Topic; D018084:Ultrasonography, Interventional / Q000379:methods
chemical_list: D008076:Cholesterol, HDL