title: Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells.
abstract: The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.
authors: QOPNA and Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal. jtome@ua.pt.
authors: Patrícia M R
authors: PM
authors: Pereira
authors: José J
authors: JJ
authors: Carvalho
authors: Sandrina
authors: S
authors: Silva
authors: José A S
authors: JA
authors: Cavaleiro
authors: Rudolf J
authors: RJ
authors: Schneider
authors: Rosa
authors: R
authors: Fernandes
authors: João P C
authors: JP
authors: Tomé
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry*; D045744:Cell Line, Tumor; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use; D011166:Porphyrins / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012709:Serum Albumin / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D017319:Photosensitizing Agents; D011166:Porphyrins; D017382:Reactive Oxygen Species; D012709:Serum Albumin