title: Finding a needle in a haystack: Activation-induced CD137 expression accurately identifies naturally occurring tumor-reactive T cells in cancer patients.
abstract: We have recently identified tumor necrosis factor receptor superfamily, member 9 (TNFRSF9, best known as CD137 or 4-1BB) as a biomarker of tumor-reactive T cells naturally occurring in cancer patients, and developed a rapid, accurate system to comprehensively isolate lymphocytes with tumor-rejecting properties from human biopsies. Our findings reveal a previously unappreciated role for CD137, a co-stimulatory TNFR family member, in the immunobiology of human cancer.
authors: Ovarian Cancer Research Center; Department of Obstetrics and Gynecology; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA.
authors: Qunrui
authors: Q
authors: Ye
authors: Ovarian Cancer Research Center; Department of Obstetrics and Gynecology; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA.
authors: De-Gang
authors: DG
authors: Song
authors: Ovarian Cancer Research Center; Department of Obstetrics and Gynecology; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA ; Department of Pathology and Laboratory Medicine; Abramson Cancer Center; Perelman School of Medicine; University of Pennsylvania; Philadelphia, PA USA.
authors: Daniel J
authors: DJ
authors: Powell
keywords: 4-1BB; CD137, adoptive immunotherapy, enrichment, tumor-associated antigens, tumor-infiltrating lymphocytes