title: Large monophasic synovial sarcoma: a case report and review of the literature.
abstract: Synovial sarcomas account for approximately 8% of all soft tissue tumors. The hallmark tumor marker is the t(X;18) translocation, which results in fusion of the SYT gene of chromosome 18 to the SSX gene of the X chromosome, creating most frequently either an SYT-SSX1 or SYT-SSX2 transfusion transcript. Clinically, synovial sarcomas most often present on the extremities and average roughly 7 cm in diameter. Metastatic spread to regional lymph nodes and/or the lungs is common. Because the incidence of this tumor is low, most studies have been retrospective; therefore, management and prognostic interpretation has remained controversial. We report a case of a patient who presented with a slowly growing, unusually large mass on the left forearm of 10 years' duration. A diagnosis of monophasic synovial sarcoma was confirmed by biopsy. We also review the literature regarding management strategies for synovial sarcomas.
authors: Department of Dermatology, Health Sciences Center, School of Medicine, Stony Brook University, 100 Nicolls Rd, Stony Brook, NY 11794, USA. David.silverstein@hsc.stonybrook.edu.
authors: David
authors: D
authors: Silverstein
authors: Peter
authors: P
authors: Klein
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D001706:Biopsy; D002887:Chromosomes, Human, Pair 18; D005260:Female; D005542:Forearm; D006801:Humans; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D011379:Prognosis; D013584:Sarcoma, Synovial / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein