title: Lack of associations between genetic polymorphisms in GSTM1, GSTT1 and GSTP1 and pancreatic cancer risk: a multi-institutional case-control study in Japan.
abstract: BACKGROUND
  We aimed to evaluate the role of genetic polymorphisms in tobacco carcinogen-metabolizing genes and their interactions with smoking in a hospital-based case-control study of Japanese subjects.
  
  
  METHODS
  We examine the associations of pancreatic cancer risk with genetic polymorphisms in GSTM1, GSTT1 and GSTP1, phase II enzymes that catalyze the conjugation of toxic and carcinogenic electrophilic molecules. The study population consisted of 360 patients and 400 control subjects, who were recruited from several medical facilities in Japan. Unconditional logistic regression methods were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and pancreatic cancer risk.
  
  
  RESULTS
  Among the control subjects, the prevalence of the GSTM1-null genotype and the GSTT1-null genotype was approximately 56% and 48%, respectively. Cases and controls were comparable in terms of GSTM1 and GSTT1 genotype distributions. Neither of the deleted polymorphisms in GSTM1 and GSTT1 was associated with the risk of pancreatic cancer, with an age- and sex-adjusted OR of 0.99 (95%CI: 0.74-1.32) for the GSTM1-null genotype, and 0.98 (95%CI: 0.73-1.31) for the GSTT1-null genotype. The OR was 0.97 (95%CI: 0.64-1.47) for individuals with the GSTM1 and GSTT1-null genotypes compared with those with the GSTM1 and GSTT1- present genotypes. No synergistic effects of smoking or GST genotypes were observed.
  
  
  CONCLUSIONS
  Our results indicate no overall association between the GSTM1 and GSTT1 deletion polymorphisms and pancreatic cancer risk in the Japanese subjects in our study.
authors: Hepatobiliary and Pancreatic Section, Gastroenterological Division, Cancer Institute Hospital, Tokyo, Japan E-mail : linys@aichi-med-u.ac.jp.
authors: Ikuhiro
authors: I
authors: Yamada
authors: Masato
authors: M
authors: Matsuyama
authors: Masato
authors: M
authors: Ozaka
authors: Dai
authors: D
authors: Inoue
authors: Yusuke
authors: Y
authors: Muramatsu
authors: Hiroshi
authors: H
authors: Ishii
authors: Ueda
authors: U
authors: Junko
authors: Makoto
authors: M
authors: Ueno
authors: Naoto
authors: N
authors: Egawa
authors: Haruhisa
authors: H
authors: Nakao
authors: Mitsuru
authors: M
authors: Mori
authors: Keitaro
authors: K
authors: Matsuo
authors: Takeshi
authors: T
authors: Nishiyama
authors: Shinichi
authors: S
authors: Ohkawa
authors: Satoyo
authors: S
authors: Hosono
authors: Kenji
authors: K
authors: Wakai
authors: Kozue
authors: K
authors: Nakamura
authors: Akiko
authors: A
authors: Tamakoshi
authors: Sawako
authors: S
authors: Kuruma
authors: Masanori
authors: M
authors: Nojima
authors: Mami
authors: M
authors: Takahashi
authors: Kazuaki
authors: K
authors: Shimada
authors: Kiyoko
authors: K
authors: Yagyu
authors: Shogo
authors: S
authors: Kikuchi
authors: Yingsong
authors: Y
authors: Lin
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000201:enzymology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human