title: The chemistry and biological potential of azetidin-2-ones.
abstract: Azetidin-2-ones, commonly referred as β-lactams, represent a unique ring system, with interesting chemistry and great biological potential. Besides its well known antibiotic activity, this ring system exhibits a wide range of activities, attracting the attention of researchers. The biological and pharmacological profile of azetidin-2-ones is reviewed here comprehensively with several examples under fourteen different activity heads. The chemistry and methods of synthesis have also been discussed.
authors: Department of Chemistry, Banasthali University, Tonk 304022, Rajasthan, India; Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410401, Maharashtra, India.
authors: Nikhilesh
authors: N
authors: Arya
authors: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410401, Maharashtra, India.
authors: Archana Y
authors: AY
authors: Jagdale
authors: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410401, Maharashtra, India.
authors: Tushar A
authors: TA
authors: Patil
authors: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410401, Maharashtra, India.
authors: Shradha S
authors: SS
authors: Yeramwar
authors: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410401, Maharashtra, India.
authors: Sidharam S
authors: SS
authors: Holikatti
authors: Department of Chemistry, Banasthali University, Tonk 304022, Rajasthan, India.
authors: Jaya
authors: J
authors: Dwivedi
authors: B.V. Patel Pharmaceutical Education and Research Development (PERD) Centre, S.G. Highway, Thaltej, Ahmedabad 380 054, Gujarat, India.
authors: Chamanlal J
authors: CJ
authors: Shishoo
authors: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Lonavala, Pune 410401, Maharashtra, India. Electronic address: drkishorsjain@gmail.com.
authors: Kishor S
authors: KS
authors: Jain
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests
chemical_list: C116379:2-azetidinone; D000890:Anti-Infective Agents; D001384:Azetidines
keywords: Azetidin-2-ones; Pharmacological profile; Synthesis; β-Lactam