title: Oral lichenoid tissue reactions: diagnosis and classification.
abstract: The concept of lichenoid tissue reaction/interface dermatitis was introduced in dermatology to define a number of diverse inflammatory skin diseases linked together by the presence of common histopathological features. Similarly to the skin, the oral mucosa is affected by a variety of oral lichenoid lesions. Oral LTRs (OLTRs) include: oral lichen planus; oral lichenoid contact lesion; oral lichenoid drug reaction; oral lichenoid lesions of graft-versus-host disease; oral discoid lupus erythematosus; oral lesions of systemic lupus erythematosus; erythema multiforme; paraneoplastic pemphigus/paraneoplastic autoimmune multiorgan syndrome; chronic ulcerative stomatitis and lichen planus pemphigoid. Traditionally, diagnosis of OLTRs relies on clinical and histological correlation but in several instances this approach fails to provide a reliable diagnosis. Inclusion of molecular techniques may refine our ability to differentiate OLTRs.
authors: Oral Medicine Department, Centre for Oral Health Research, Newcastle University, Framlington Place, NE2 4BW, Newcastle upon Tyne, UK.
authors: Ahmed Salih
authors: AS
authors: Khudhur
authors: Giovanni
authors: G
authors: Di Zenzo
authors: Marco
authors: M
authors: Carrozzo
mesh_terms: D003793:Dental Restoration, Permanent / Q000009:adverse effects; D003880:Dermatology / Q000379:methods; D004892:Erythema Multiforme / Q000175:diagnosis; D005892:Gingivitis, Necrotizing Ulcerative / Q000175:diagnosis; D006086:Graft vs Host Disease; D006801:Humans; D017676:Lichen Planus, Oral / Q000145:classification / Q000175:diagnosis*; D017512:Lichenoid Eruptions / Q000145:classification / Q000175:diagnosis*; D008179:Lupus Erythematosus, Discoid / Q000150:complications; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D009061:Mouth Mucosa / Q000276:immunology* / Q000473:pathology; D010391:Pemphigoid, Bullous / Q000175:diagnosis; D010392:Pemphigus / Q000175:diagnosis