title: What We Know About Diet, Genes, and Dyslipidemia: Is There Potential for Translation?
abstract: Cardiovascular disease, particularly coronary artery disease (CAD), is the leading cause of death in the United States. Dyslipidemia, including elevated low density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels and low high density lipoprotein cholesterol (HDL-C), is a well-established risk factor for CAD and is influenced by both genetic and lifestyle factors, including the diet and dietary fat in particular. Major strides in elucidating the genetic basis for dyslipidemia have been made in recent years, and the quest to clarify how genetic differences influence lipid response to dietary intervention continues. Some monogenic conditions such as famililal hypercholesterolemia and sitosterolemia already have customized dietary recommendations. Some promising associations have emerged for more polygenic dyslipidemia, but further studies are needed in large dietary intervention studies capturing increasing amounts of explainable genetic variation before recommendations can be made for clinical translation.
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland ; Program in Genetics and Genomic Medicine, Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, Maryland.
authors: Toni I
authors: TI
authors: Pollin
authors: Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland.
authors: Michael
authors: M
authors: Quartuccio
keywords: cholesterol; dietary fat; dietary intervention studies; gene-diet interactions; genetics; monounsaturated fat; nutrigenomics; polyunsaturated fat; triglycerides