title: Clinical value of the high expression of corticosteroid receptor-beta mRNA in the nasal mucosa of steroid-resistant patients with allergic rhinitis.
abstract: OBJECTIVE
  This study investigated clinical values of corticosteroid (CS) receptor α and β in the nasal mucosa of patients with allergic rhinitis (AR) by determining CS receptor α and β mRNA expression following steroid treatment.
  
  
  METHODS
  Among 120 outpatients, 65 had persistent AR, including 36 being sensitive to steroid treatment (steroid-sensitive group) and 29 being resistant to steroid treatment (steroid-resistant group). In addition, 30 patients with deflection of the nasal septum alone, which was corrected by surgery, were recruited as controls. Fluorescent quantitative reverse transcription-PCR was used to quantify CS receptor α and β mRNA expression in the nasal mucosa of patients.
  
  
  RESULTS
  Results showed that CS receptor β mRNA expression in the nasal mucosa was significantly higher in the steroid-resistant group [(5.62 ± 1.28) × 102 copies/µg] compared with the steroid-sensitive [(4.62 ± 0.48) × 102 copies/µg, t = -6.67, p < 0.01] and control [(5.32 ± 0.55) × 102 copies/µg, t = -8.29, p < 0.01] groups. There were significant differences in the mRNA expression ratio of CS receptor α to β between the steroid-sensitive (658.32 ± 65.16) and steroid-resistant (525.70 ± 68.10) groups (t = 10.16, p < 0.01).
  
  
  CONCLUSIONS
  A high level of CS receptor β mRNA but a low level of CS receptor α mRNA expression in patients with steroid-resistant AR indicates steroid resistance. CS receptor β plays a role in evaluating the effects of steroid therapy for AR.
authors: Department of Otorhinolaryngology, Hospital Affiliated to Hubei University of Arts and Science, Xiangyang Central Hospital, Xiangyang, China.
authors: Hong
authors: H
authors: Luo
authors: Jian-bin
authors: JB
authors: Zhang
authors: Ye
authors: Y
authors: Yu
authors: Jun
authors: J
authors: Liu
authors: Yan
authors: Y
authors: Jiang
authors: Neng-bing
authors: NB
authors: Yan
authors: Peng-ju
authors: PJ
authors: Wang
mesh_terms: D000328:Adult; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D065631:Rhinitis, Allergic / Q000188:drug therapy* / Q000378:metabolism*; D013256:Steroids / Q000627:therapeutic use*
chemical_list: D012333:RNA, Messenger; D011965:Receptors, Glucocorticoid; D013256:Steroids; C121943:glucocorticoid receptor beta