title: Study on preparation of fibrinogen-loaded poly (L-lactic) acid nano-fabrics and its haemostatic performance in swine traumatic haemorrhage models.
abstract: Haemorrhage is the major cause of death in civilian trauma and the leading cause of preventable death in military trauma. It is very important to develop a haemostatic material with definite haemostatic effects. In this study, a nano-fabric membrane containing fibrinogen (Fbg) (2.5%, w/v) was successfully prepared by electrospinning as a haemostatic dressing. The average fibre diameter was 400 nm by scanning electron microscope (SEM), and it was indicated that fibrinogen and fibrin possessed excellent compatibility with poly (L-lactic)-acid (PLLA) from X-ray diffraction (XRD). Swine traumatic haemorrhage models including spleen haemorrhage, liver haemorrhage and femoral arteriovenous fistula haemorrhage were developed to detect haemostatic effects of this dressing. The results showed that the Fbg-loaded PLLA nano-fibre can significantly decrease the bleeding time, blood loss and mortality rate, which suggested that Fbg-loaded PLLA nano-fibre was efficacious on the models of traumatic uncontrolled haemorrhage, and further study of this dressing would be warranted to determine its potential in first aid and field trauma care.
authors: aDepartment of Pharmcy, 454th Hospital of PLA, Najing bDepartment of Pharmaceutical Science & Technology, Donghua University, Shanghai, China.
authors: Yan
authors: Y
authors: Qiu
authors: Yuan-Yuan
authors: YY
authors: Zhu
authors: Yi-Jia
authors: YJ
authors: Yan
authors: Na
authors: N
authors: Chen
authors: Zhi-Long
authors: ZL
authors: Chen
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005340:Fibrinogen / Q000378:metabolism*; D006490:Hemostatics; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism*; D008855:Microscopy, Electron, Scanning / Q000379:methods*; D013499:Surface Properties; D013552:Swine
chemical_list: D006490:Hemostatics; D019344:Lactic Acid; D005340:Fibrinogen