title: Bipolar disorder and anxiety disorders.
abstract: BACKGROUND
  Anxiety disorders are common in patients with bipolar disorder and show considerable influence on the course of the disease and response to treatment.
  
  
  METHODS
  We conducted a series of literature searches using key words, such as bipolar disorder and anxiety disorders, as items in indexed fields. The studies were obtained through a MEDLINE search from 1970 to 2012. We also examined additional studies cited in articles from these searches or our previous studies.
  
  
  RESULTS
  Several studies have shown poorer outcomes for patients with bipolar and comorbid anxiety disorders. Some studies have indicated worse outcomes in patients with bipolar disorder and associated anxiety disorders. Shorter periods of euthymia, increased suicidal thoughts and an increased number of suicide attempts were observed. Whether the effective treatment of anxiety reduces suicide and the severity of bipolar disorder or improves the response to treatment remains unknown. There are no well-designed intervention studies in bipolar patients with anxiety symptoms.
  
  
  CONCLUSIONS
  Further studies concerning the influence of anxiety on the course of bipolar disorder would be useful.
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic. klaralat@centrum.cz.
authors: Klara
authors: K
authors: Latalova
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic.
authors: Jan
authors: J
authors: Prasko
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic.
authors: Ales
authors: A
authors: Grambal
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic.
authors: Petra
authors: P
authors: Havlikova
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic.
authors: Daniela
authors: D
authors: Jelenova
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic.
authors: Barborá
authors: B
authors: Mainerova
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic.
authors: Dana
authors: D
authors: Kamaradova
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic.
authors: Marie
authors: M
authors: Ociskova
authors: Faculty of Philosophy, Department of Psychology, Palacky University Olomouc, Czech Republic.
authors: Zuzana
authors: Z
authors: Sedlackova
authors: Department of Psychiatry, Faculty of Medicine and Dentistry, University Palacky Olomouc, University Hospital Olomouc, Czech Republic.
authors: Aneta
authors: A
authors: Sandoval
mesh_terms: D001008:Anxiety Disorders / Q000453:epidemiology*; D001714:Bipolar Disorder / Q000453:epidemiology*; D015897:Comorbidity; D006801:Humans; D016584:Panic Disorder / Q000453:epidemiology*; D015995:Prevalence