title: Immobilization of coacervate microcapsules in multilayer sodium alginate beads for efficient oral anticancer drug delivery.
abstract: We have designed and evaluated coacervate microcapsules-immobilized multilayer sodium alginate beads (CMs-M-ALG-Beads) for oral drug delivery. The CMs-M-ALG-Beads were prepared by immobilization of doxorubicin hydrochloride (DOX) loaded chitosan/carboxymethyl coacervate microcapsules (DOX:CS/CMCS-CMs) in the core and layers of the multilayer sodium alginate beads. The obtained CMs-M-ALG-beads exhibited layer-by-layer structure and rough surface with many nanoscale particles. The swelling characteristic and drug release results indicated that 4-layer CMs-M-ALG-Beads possessed favorable gastric acid tolerance (the swelling rate <5%, the cumulative drug release rate <3.8%). In small intestine, the intact DOX:CS/CMCS-CMs were able to rapidly release from CMs-M-ALG-Beads with the dissolution of ALG matrix. Ex vivo intestinal mucoadhesive and permeation showed that CMs-M-ALG-Beads exhibited continued growth for P(app) values of DOX, which was 1.07-1.15 folds and 1.28-1.38 folds higher than DOX:CS:CMCS-CMs in rat jejunum and ileum, respectively, demonstrating that CMs-M-ALG-Beads were able to enhance the absorption of DOX by controlled releasing DOX:CS/CMCS-CMs and prolonging the contact time between the DOX:CS/CMCS-CMs and small intestinal mucosa.
authors: College of Marine Life Science, Ocean University of China , Yushan Road, Qingdao 266003, Shandong Province, People's Republic of China.
authors: Chao
authors: C
authors: Feng
authors: Ruixi
authors: R
authors: Song
authors: Guohui
authors: G
authors: Sun
authors: Ming
authors: M
authors: Kong
authors: Zixian
authors: Z
authors: Bao
authors: Yang
authors: Y
authors: Li
authors: Xiaojie
authors: X
authors: Cheng
authors: Dongsu
authors: D
authors: Cha
authors: Hyunjin
authors: H
authors: Park
authors: Xiguang
authors: X
authors: Chen
mesh_terms: D000284:Administration, Oral; D000464:Alginates / Q000737:chemistry; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D002214:Capsules / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage* / Q000737:chemistry; D016503:Drug Delivery Systems; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D008863:Microspheres; D009369:Neoplasms / Q000188:drug therapy*; D051381:Rats
chemical_list: D000464:Alginates; D000970:Antineoplastic Agents; D002214:Capsules; D006603:Hexuronic Acids; D004317:Doxorubicin; D020723:Glucuronic Acid