title: Cardiovascular biomarkers in vertically HIV-infected children without metabolic abnormalities.
abstract: Early cardiovascular disease is a major concern for ART-suppressed vertically HIV-infected children; however, evidence is lacking regarding specific preventive measures. In this study, a complete panel of biomarkers was determined together with carotid intima-media thickness (IMT), in a cohort of 64 HIV-infected children and 30 controls. Mean age of participants was 14.1±5 years. HIV-infected patients showed normal lipid profile, with only slightly higher triglycerides, and no differences between groups were found regarding IMT. HIV-infected patients displayed higher levels of soluble CD14 (sCD14) and soluble vascular cell adhesion molecule-1 (sVCAM) (all p<0.05). However, levels of C-reactive protein, interleukin-6, myeloperoxidase, monocyte chemoattractant protein-1, P-selectin and tissue plasminogen activator were similar between groups. Vertically HIV-infected subjects on ART with no significant metabolic disturbances displayed increased sCD14 and sVCAM but not up-regulation of proinflammatory pathways. Larger studies are warranted to assess the impact of a strict metabolic control on cardiovascular risk and to define specific cardiovascular disease preventive strategies in this population.
authors: Laboratorio de InmunoBiología Molecular, Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IISHGM), C/ Dr Esquerdo 46, 28007 Madrid, Spain. Electronic address: tsaincosta@gmail.com.
authors: Talía
authors: T
authors: Sainz
authors: Laboratorio de InmunoBiología Molecular, Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IISHGM), C/ Dr Esquerdo 46, 28007 Madrid, Spain.
authors: Laura
authors: L
authors: Diaz
authors: Servicio de Pediatría, Hospital Gregorio Marañón, 28007 Madrid, Spain.
authors: María Luisa
authors: ML
authors: Navarro
authors: Unidad de Inmunodeficiencias pediátricas, Servicio de Pediatría, Hospital Universitario Doce de Octubre, 28026 Madrid, Spain.
authors: Pablo
authors: P
authors: Rojo
authors: Unidad de Inmunodeficiencias pediátricas, Servicio de Pediatría, Hospital Universitario Doce de Octubre, 28026 Madrid, Spain.
authors: Daniel
authors: D
authors: Blázquez
authors: Servicio de Pediatría, Hospital de Getafe, 28905 Madrid, Spain.
authors: José Tomás
authors: JT
authors: Ramos
authors: Servicio de Pediatría, Hospital Infantil La Paz, 28040 Madrid, Spain.
authors: María Isabel
authors: MI
authors: de José
authors: Servicio de Pediatría, Hospital Gregorio Marañón, 28007 Madrid, Spain.
authors: María
authors: M
authors: Álvarez-Fuente
authors: Servicio de Enfermedades Infecciosas e IRYCIS, Hospital Ramón y Cajal, 28034 Madrid, Spain.
authors: Sergio
authors: S
authors: Serrano-Villar
authors: Servicio de Pediatría, Hospital Carlos III, 28029 Madrid, Spain.
authors: María José
authors: MJ
authors: Mellado
authors: Laboratorio de InmunoBiología Molecular, Instituto de Investigación Sanitaria Hospital Gregorio Marañón (IISHGM), C/ Dr Esquerdo 46, 28007 Madrid, Spain. Electronic address: mmunoz.hgugm@gmail.com.
authors: María Angeles
authors: MA
authors: Muñoz-Fernández
mesh_terms: D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D015415:Biomarkers; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology*; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D002648:Child; D016207:Cytokines / Q000097:blood; D004198:Disease Susceptibility; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000097:blood* / Q000151:congenital / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission; D006487:Hemostasis; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology; D018445:Infectious Disease Transmission, Vertical; D008055:Lipids / Q000097:blood; D018950:Lipopolysaccharide Receptors / Q000097:blood*; D008297:Male; D011446:Prospective Studies; D016037:Single-Blind Method; D012907:Smoking / Q000097:blood / Q000453:epidemiology; D013030:Spain / Q000453:epidemiology; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D016207:Cytokines; D008055:Lipids; D018950:Lipopolysaccharide Receptors; D019010:Vascular Cell Adhesion Molecule-1
keywords: CRP; Cardiovascular biomarkers; Cardiovascular risk; Children and adolescents; HIV; IMT; sCD14