title: Omentin and chemerin and their association with obesity in women with polycystic ovary syndrome.
abstract: We aimed to investigate whether overweight/obesity is associated with omentin and chemerin. The study group consisted of 81 women with Polycystic ovarian syndrome (PCOS) (41 lean, BMI < 25 kg/m² and 40 overweight or obese, BMI > 25 kg/m²) and 61 healthy subjects (31 lean, BMI < 25 kg/m² and 30 overweight or obese, BMI > 25 kg/m²; control group). The clinical, endocrine, metabolic parameters, plasma omentin and chemerin levels were measured in patients and compared to control. In all subjects with PCOS (n = 80), serum chemerin levels were higher compared with those of the controls (n = 58) (7.71 ± 1.78 ng/mL versus 6.94 ± 0.82 ng/mL, p = 0.003). However, serum omentin levels were not significantly different between the PCOS subjects and the controls (1.55 ± 0.43 ng/mL versus 1.69 ± 0.37 ng/mL, p = 0.056). The mean chemerin concentrations were significantly elevated in the obese PCOS group compared with the obese control subjects (8.98 ± 1.45 ng/mL versus 7.02 ± 0.67 ng/mL, p = 0.000) and the nonobese PCOS group compared with the obese control subjects (6.57 ± 1.17 ng/mL versus 7.02 ± 0.67 ng/mL, p = 0.000). In conclusion, fat mass seems to be the main determinant factor of increased chemerin and decreased omentin in women with PCOS.
authors: Department of Family Medicine .
authors: Eda Celik
authors: EC
authors: Guzel
authors: Cem
authors: C
authors: Celik
authors: Remzi
authors: R
authors: Abali
authors: Volkan
authors: V
authors: Kucukyalcin
authors: Elcin
authors: E
authors: Celik
authors: Murat
authors: M
authors: Guzel
authors: Murat
authors: M
authors: Yilmaz
mesh_terms: D050154:Adiposity; D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D018925:Chemokines / Q000097:blood*; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D015536:Down-Regulation; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006785:Hospitals, University; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D037102:Lectins / Q000097:blood*; D009765:Obesity / Q000503:physiopathology*; D010044:Outpatient Clinics, Hospital; D050177:Overweight / Q000503:physiopathology*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000209:etiology*; D014421:Turkey; D015854:Up-Regulation; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D018925:Chemokines; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D037102:Lectins; C478630:RARRES2 protein, human
keywords: Androgen; chemerin; insulin resistance; omentin; polycystic ovary syndrome