title: [Comparative analysis of structural changes in thrombocytes during Alzheimer's and Parkinson's diseases].
abstract: The paper deals with the study of the changes in the formed elements of blood during the Alzheimer's and Parkinson's diseases. While studying the structure of thrombocytes, a number of identical structural changes were identified in case of both diseases. The study has revealed various shapes of thrombocytes, the production of pseudopodia on their surface, high level of body outline, specific distribution of glycogen granules and their concentration on the periphery, glycogen eruption, dissociation of Alpha-granules towards the edge, and effective outline and density of the granules. There are frequent cases of the granule eruption from the body (exocytosis), the existence of vacuoles on the matrix, the rise in the number of gigantic thrombocytes and, consequently, considerable enhancement of the ability of absorption. Besides, there is a rise in the number of degenerated cells. The shape of thrombocytes is often changed and stretched on one side. The produced pseudopodia make the impression of participation in phagocytosis. As for the difference between changes, during Parkinson disease the amount of thrombocytes is low, more gigantic and distorted shape, less invagination of plasma membrane, low amount of granules and less intensity of alpha-granule eruption from the body. The changes revealed by the research show the activity of thrombocytes, which should be connected to their participation in protective functions of the body towards existing agent. And the diseases - although with similar but with different pathogenic mechanisms - are being developed with participation of non-specific agents.
authors: Tbilisi State Medical University, Department of Neuromedicine, Tbilisi, Georgia.
authors: V
authors: V
authors: Simonidze
authors: Tbilisi State Medical University, Department of Neuromedicine, Tbilisi, Georgia.
authors: O
authors: O
authors: Samushia
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000097:blood*; D001792:Blood Platelets / Q000648:ultrastructure*; D016022:Case-Control Studies; D006801:Humans; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*