title: Health consequences of exposure to brominated flame retardants: a systematic review.
abstract: BACKGROUND
  Brominated flame retardants (BFRs), are chemicals widely used in consumer products including electronics, vehicles, plastics and textiles to reduce flammability. Experimental animal studies have confirmed that these compounds may interfere with thyroid hormone homeostasis and neurodevelopment but to date health effects in humans have not been systematically examined.
  
  
  OBJECTIVE
  To conduct a systematic review of studies on the health impacts of exposure to BFRs in humans, with a particular focus on children.
  
  
  METHODS
  A systematic review was conducted using the MEDLINE and EMBASE electronic databases up to 1 February 2012. Published cohort, cross-sectional, and case-control studies exploring the relationship between BFR exposure and various health outcomes were included.
  
  
  RESULTS
  In total, 36 epidemiological studies meeting the pre-determined inclusion criteria were included. Plausible outcomes associated with BFR exposure include diabetes, neurobehavioral and developmental disorders, cancer, reproductive health effects and alteration in thyroid function. Evidence for a causal relationship between exposure to BFRs and health outcomes was evaluated within the Bradford Hill framework.
  
  
  CONCLUSIONS
  Although there is suggestive evidence that exposure to BFRs is harmful to health, further epidemiological investigations particularly among children, and long-term monitoring and surveillance of chemical impacts on humans are required to confirm these relationships.
authors: The University of Queensland, School of Population Health, Herston, QLD 4006, Australia. Electronic address: young.kim3@uqconnect.edu.au.
authors: Young Ran
authors: YR
authors: Kim
authors: Queensland University of Technology, School of Clinical Sciences and Institute of Health and Biomedical Innovation, George St., Brisbane, QLD 4000, Australia.
authors: Fiona A
authors: FA
authors: Harden
authors: Queensland University of Technology, School of Clinical Sciences and Institute of Health and Biomedical Innovation, George St., Brisbane, QLD 4000, Australia.
authors: Leisa-Maree L
authors: LM
authors: Toms
authors: The University of Queensland, School of Population Health, Herston, QLD 4006, Australia; The University of Queensland, Queensland Children's Medical Research Institute, Herston, QLD 4029, Australia.
authors: Rosana E
authors: RE
authors: Norman
mesh_terms: D001526:Behavioral Symptoms / Q000139:chemically induced / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D002658:Developmental Disabilities / Q000139:chemically induced / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis*; D005411:Flame Retardants / Q000506:poisoning*; D006801:Humans; D006842:Hydrocarbons, Brominated / Q000506:poisoning*
chemical_list: D005411:Flame Retardants; D006842:Hydrocarbons, Brominated
keywords: Brominated flame retardants; Children; Exposure; Health; Human