title: Three-dimensional personalized Monte Carlo dosimetry in 90Y resin microspheres therapy of hepatic metastases: nontumoral liver and lungs radiation protection considerations and treatment planning optimization.
abstract: In the last decades, selective internal radiation therapy (SIRT) has become a real alternative in the treatment of unresectable hepatic cancers. In practice, the activity prescription is limited by the irradiation of organs at risk (OAR), such as the lungs and nontumoral liver (NTL). Its clinical implementation is therefore highly dependent on dosimetry. In that context, a 3-dimensional personalized dosimetry technique--personalized Monte Carlo dosimetry (PMCD)-based on patient-specific data and Monte Carlo calculations was developed and evaluated retrospectively on clinical data.
  
  
  METHODS
  The PMCD method was evaluated with data from technetium human albumin macroaggregates ((99m)Tc-MAA) evaluations of 10 patients treated for hepatic metastases. Region-of-interest outlines were drawn on CT images to create patient-specific voxel phantoms using the OEDIPE software. Normalized 3-dimensional matrices of cumulated activity were generated from (99m)Tc-SPECT data. Absorbed doses at the voxel scale were then obtained with the MCNPX Monte Carlo code. The maximum-injectable activity (MIA) for tolerance criteria based on either OAR mean absorbed doses (D(mean)) or OAR dose-volume histograms (DVHs) was determined using OEDIPE. Those MIAs were compared with the one recommended by the partition model (PM) with D(mean) tolerance criteria. Finally, OEDIPE was used to evaluate the absorbed doses delivered if those activities were injected to the patient and to generate the corresponding isodose curves and DVHs.
  
  
  RESULTS
  The MIA recommended using D(mean) tolerance criteria is, in average, 27% higher with the PMCD method than with the PM. If tolerance criteria based on DVHs are used along with the PMCD, an increase of at least 40% of the MIA is conceivable, compared with the PM. For MIAs calculated with the PMCD, D(mean) delivered to tumoral liver (TL) ranged from 19.5 to 118 Gy for D(mean) tolerance criteria whereas they ranged from 26.6 to 918 Gy with DVH tolerance criteria. Thus, using the PMCD method, which accounts for fixation heterogeneities, higher doses can be delivered to TL. Finally, absorbed doses to the lungs are not the limiting criterion for activity prescription. However, D(mean) to the lungs can reach 15.0 Gy.
  
  
  CONCLUSIONS
  Besides its feasibility and applicability in clinical routine, the interest for treatment optimization of a personalized Monte Carlo dosimetry in the context of SIRT was confirmed in this study.
authors: Laboratoire d'Evaluation de la Dose Interne (LEDI), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-Aux-Roses, France.
authors: Alice
authors: A
authors: Petitguillaume
authors: Michela
authors: M
authors: Bernardini
authors: Lama
authors: L
authors: Hadid
authors: Claire
authors: C
authors: de Labriolle-Vaylet
authors: Didier
authors: D
authors: Franck
authors: Aurélie
authors: A
authors: Desbrée
mesh_terms: D006801:Humans; D008099:Liver / Q000528:radiation effects; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D008168:Lung / Q000528:radiation effects; D008863:Microspheres; D009010:Monte Carlo Method; D058958:Organs at Risk / Q000528:radiation effects*; D057285:Precision Medicine; D011835:Radiation Protection / Q000379:methods*; D011874:Radiometry / Q000379:methods*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012117:Resins, Synthetic / Q000737:chemistry; D012189:Retrospective Studies; D015021:Yttrium Radioisotopes / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D012117:Resins, Synthetic; D015021:Yttrium Radioisotopes
keywords: Monte Carlo dosimetry; OEDIPE; SIRT; dose-volume histograms; hepatic metastases