title: Development of mast cells and importance of their tryptase and chymase serine proteases in inflammation and wound healing.
abstract: Mast cells (MCs) are active participants in blood coagulation and innate and acquired immunity. This review focuses on the development of mouse and human MCs, as well as the involvement of their granule serine proteases in inflammation and the connective tissue remodeling that occurs during the different phases of the healing process of wounded skin and other organs. The accumulated data suggest that MCs, their tryptases, and their chymases play important roles in tissue repair. While MCs initially promote healing, they can be detrimental if they are chronically stimulated or if too many MCs become activated at the same time. The possibility that MCs and their granule serine proteases contribute to the formation of keloid and hypertrophic scars makes them potential targets for therapeutic intervention in the repair of damaged skin.
authors: Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors: Jeffrey
authors: J
authors: Douaiher
authors: Division of General Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky, USA.
authors: Julien
authors: J
authors: Succar
authors: Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors: Luca
authors: L
authors: Lancerotto
authors: Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors: Michael F
authors: MF
authors: Gurish
authors: Division of Plastic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors: Dennis P
authors: DP
authors: Orgill
authors: Division of Gastroenterology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors: Matthew J
authors: MJ
authors: Hamilton
authors: Department of Infectious Disease, Immunology, and Sexual Health, The St. George Hospital, University of New South Wales, Kogarah, New South Wales, Australia.
authors: Steven A
authors: SA
authors: Krilis
authors: Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address: rstevens@rics.bwh.harvard.edu.
authors: Richard L
authors: RL
authors: Stevens
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000201:enzymology / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology*; D005333:Fetus; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000276:immunology* / Q000473:pathology; D008099:Liver / Q000166:cytology / Q000201:enzymology / Q000276:immunology; D008407:Mast Cells / Q000201:enzymology* / Q000276:immunology* / Q000473:pathology; D051379:Mice; D053802:Tryptases / Q000502:physiology*; D014945:Wound Healing / Q000276:immunology*
chemical_list: D053802:Tryptases
keywords: Chymase; Connective tissue remodeling; Inflammation; Mast cell; Matrix metalloproteinase; Serine protease; Tryptase; Wound healing