title: One stone kills three birds: novel boron-containing vesicles for potential BNCT, controlled drug release, and diagnostic imaging.
abstract: A new conjugate polymer was prepared by an efficient thiol-ene coupling of one carborane with a linear PEG chain (Mn = 2,000 g/mol), and each carborane was further labeled with a fluorescence rhodamine dye. Such a novel polymer can associate in water to form narrowly distributed spherical vesicles, which were characterized using a range of methods, including laser light scattering, confocal laser scanning microscopy, and TEM. The vesicular structure is potentially multifunctional in biomedical applications, namely, serving as a boron neutron capture therapy (BNCT) agent, a hydrophilic drug carrier, and a diagnostic imaging fluorescent probe. As expected, either cleaving the thiol-ene linked PEO chain by esterase or destroying carborane by neutron irradiation results in a dismantlement of such a vesicle structure to release its encapsulated drugs. Its potential biomedical applications have been evaluated in vitro and in vivo. Our preliminary results reveal that these small vesicles can be quickly taken up by cells and have an enhanced stability in the bloodstream so that their targeting to specific cancer cells becomes feasible.
authors: Department of Chemistry, The Chinese University of Hong Kong , Shatin, New Territories, Hong Kong.
authors: Gaojian
authors: G
authors: Chen
authors: Jingying
authors: J
authors: Yang
authors: Gang
authors: G
authors: Lu
authors: Pi Chu
authors: PC
authors: Liu
authors: Qianjin
authors: Q
authors: Chen
authors: Zuowei
authors: Z
authors: Xie
authors: Chi
authors: C
authors: Wu
mesh_terms: D000818:Animals; D001895:Boron; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D003692:Delayed-Action Preparations; D003952:Diagnostic Imaging / Q000379:methods*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008297:Male; D051379:Mice; D018613:Microscopy, Confocal; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D001895:Boron
keywords: BNCT; carborane; controlled drug release; diagnostic imaging; laser light scattering; polymeric vesicles