title: External validation of TNM-C score in three community hospital cohorts for clear cell renal cell carcinoma.
abstract: OBJECTIVE
  To assess the general applicability of TNM-C scoring, which consists of TNM classification and preoperative C-reactive protein concentration, the predictive ability of the TNM-C score was externally validated for patients with clear cell renal cell carcinoma (ccRCC) at three community hospitals.
  
  
  METHODS
  Seven hundred patients underwent radical or partial nephrectomy after being diagnosed with RCC. Out of the 700 patients, 518 with clear cell carcinoma served as the current study cohort. The predictive ability of the TMN-C score for cancer-specific survival (CSS) was estimated using Harrell's concordance index (c-index).
  
  
  RESULTS
  The c-index of the TNM-C score was 0.85 in the entire data set. CSS rates were clearly stratified according to the scoring model (p<0.001).
  
  
  CONCLUSIONS
  Since TNM-C score alone (without pathological details) has a high predictive ability for the prognosis of ccRCC patients, it is generally applicable for use in community hospitals.
authors: Department of Urology, Tokyo Medical and Dental University Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. kz-saito.uro@tmd.ac.jp.
authors: Takayuki
authors: T
authors: Nakayama
authors: Kazutaka
authors: K
authors: Saito
authors: Junichiro
authors: J
authors: Ishioka
authors: Keizo
authors: K
authors: Kawano
authors: Shinji
authors: S
authors: Morimoto
authors: Yoh
authors: Y
authors: Matsuoka
authors: Tetsuo
authors: T
authors: Okuno
authors: Shingo
authors: S
authors: Moriyama
authors: Hideki
authors: H
authors: Takeshita
authors: Akira
authors: A
authors: Noro
authors: Yasuhisa
authors: Y
authors: Fujii
authors: Kazunori
authors: K
authors: Kihara
mesh_terms: D000465:Algorithms; D002097:C-Reactive Protein / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000473:pathology* / Q000601:surgery; D015331:Cohort Studies; D006764:Hospitals, Community; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood* / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D012189:Retrospective Studies
chemical_list: D002097:C-Reactive Protein
keywords: C-reactive protein; Renal cell carcinoma; TNM classification; nephrectomy; prognosis