title: Vitamin D status in migraine patients: a case-control study.
abstract: BACKGROUND
  There have been few studies on the relation between vitamin D and migraine. We investigated the prevalence of vitamin D deficiency in migraine patients and compared it with a control group. We also evaluated the relationship of vitamin D deficiency with severity of migraine.
  
  
  METHODS
  105 newly diagnosed migraine patients and 110 controls, matched for age, sex, socioeconomic status, education, and sun exposure, were enrolled during the spring of 2011. 25-Hydroxy vitamin D [25(OH)D] plasma levels were measured by chemiluminescence immunoassay.
  
  
  RESULTS
  The mean ± SE concentration of 25(OH)D was 13.55 ± 0.91 ng/mL in cases and 13.19 ± 1.19 ng/mL in controls. There was no significant difference in 25(OH)D concentration between cases and controls. We found no relationship between severity of headache and 25(OH)D status.
  
  
  CONCLUSIONS
  We did not find any association between migraine and vitamin D status; also, severity of headaches was not related to 25(OH)D level. Further studies with larger sample sizes are required to confirm our results.
authors: Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran ; Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
authors: Alireza
authors: 0000-0001-9480-949X
authors: A
authors: Zandifar
authors: Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
authors: Samaneh Sadat
authors: SS
authors: Masjedi
authors: Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
authors: Mahboobeh
authors: M
authors: Banihashemi
authors: Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
authors: Fatemeh
authors: F
authors: Asgari
authors: Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
authors: Navid
authors: N
authors: Manouchehri
authors: Medical Student Research Center, Faculty of Medicine, Islamic Azad University, NajafAbad Branch, NajafAbad 8514143131, Iran.
authors: Homa
authors: H
authors: Ebrahimi
authors: Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran ; Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran.
authors: Faraidoon
authors: F
authors: Haghdoost
authors: Physiology Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan 81745-319, Iran ; Department of Neurology and Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Hezarjarib Avenue, Isfahan 81745-319, Iran.
authors: Mohammad
authors: M
authors: Saadatnia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000473:pathology*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000473:pathology*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D