title: ERG rearrangement is associated with prostate cancer-related death in Chinese prostate cancer patients.
abstract: Recently, ETS-related gene (ERG) gene rearrangements, phosphatase tensin homologue (PTEN) deletions and EGFR family aberrations were characterized as potential biomarkers for prostate cancer (PCa) patient management. Although ERG gene rearrangement has been identified in approximately 50% of localized prostate cancers in western countries, the prognostic significance of this critical molecular event remains unknown in Chinese patients. Using fluorescence in situ hybridization (FISH) and immunohistochemistry, we evaluated ERG, PTEN and EGFR family aberrations in a cohort of 224 Chinese prostate cancer patients diagnosed in transurethral resection of the prostate (TUR-P). Overall, ERG rearrangement was detected in 23.2% (44/190) cases, of which 54.5% (24/44) showed deletion of the 5'end of ERG. PTEN deletion was identified in 10.8% (19/176) cases. Amplification of EGFR and HER2 genes was present in 1.1% (2/178) and 5.8% (10/173) of cases, respectively. Significant correlation between ERG rearrangement and PTEN deletion was identified in this cohort. EGFR and HER2 aberrations occurred more frequently in PCas without ERG rearrangement than in those with ERG rearrangement, although this did not reach statistical significance. Overall, ERG rearrangement was associated with pre-operative PSA values (P = 0.038) and cancer-related death (P = 0.02), but not with the age, clinical T stage, Gleason score, or Ki-67 labeling index (LI). Notably, multivariate analysis including known prognostic markers revealed ERG rearrangement was an independent prognostic factor (P = 0.022). Additionally, ERG rearrangement status was helpful to identify patients with poor prognosis from PCa group with low Ki-67 LI. In summary, we reported that ERG rearrangement was associated with cancer-related death in Chinese PCa patients. Determination of ERG rearrangement status allows stratification of PCa patients into different survival categories.
authors: Department of Pathology, Shandong University Medical School, Jinan, China.
authors: Mei
authors: M
authors: Qi
authors: Department of Pathology, Shandong University Medical School, Jinan, China.
authors: Xiaoqing
authors: X
authors: Yang
authors: Department of Orthodontics, Shandong University School of Stomatology, Jinan, China.
authors: Fan
authors: F
authors: Zhang
authors: Department of Surgery, The Central Hospital of Jinan, Jinan, China.
authors: Tao
authors: T
authors: Lin
authors: Department of Statistics, Shandong University School of Public Health, Jinan, China.
authors: Xiubin
authors: X
authors: Sun
authors: Department of Urology, The Affiliated Hospital of Qingdao University Medical College, Qingdao, China.
authors: Yanjiang
authors: Y
authors: Li
authors: Department of Biochemistry, Shandong University Medical School, Jinan, China.
authors: Huiqing
authors: H
authors: Yuan
authors: Department of Pathology, Liaocheng General Hospital, Liaocheng, China.
authors: Yubo
authors: Y
authors: Ren
authors: Department of Pathology, Shandong University Qilu hospital, Jinan, China.
authors: Juan
authors: J
authors: Zhang
authors: Department of Pathology, Shandong University Qilu hospital, Jinan, China.
authors: Xiaomin
authors: X
authors: Qin
authors: Department of Pathology, Shandong University Medical School, Jinan, China ; Department of Pathology, Shandong University Qilu hospital, Jinan, China.
authors: Bo
authors: B
authors: Han
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D000368:Aged; D002681:China; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D015513:Oncogene Proteins / Q000235:genetics* / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D000071230:Transcriptional Regulator ERG
chemical_list: C531115:ERG protein, mouse; D015513:Oncogene Proteins; D014157:Transcription Factors; D000071230:Transcriptional Regulator ERG; C512478:EGFR protein, human; D066246:ErbB Receptors; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human