title: Clinical significance of P-glycoprotein and glutathioneS-transferase π expression in gallbladder carcinoma.
abstract: P-glycoprotein (P-gp) and glutathioneS-transferase π (GST-π) are not only drug-resistance markers, but also prognostic markers of various cancers. The aim of the present study was to investigate the clinical significance of P-gp and GST-π in gallbladder carcinoma (GBC). Tissue samples from 42 patients with GBC were immunostained. Demographic, clinical and follow-up data were collected and analyzed. The positive expression rates of P-gp and GST-π in the GBC tissues were significantly higher (76.2 and 64.3%, respectively) than that of chronic cholecystitis specimens (30 and 20%, respectively) (P=0.014 and 0.035, respectively), and correlated with the Nevin stage of GBC. Multivariate analysis demonstrated that patients with positive expression of P-gp and GST-π showed a significantly lower 2-year survival rate (11.1 and 12%, respectively) compared with patients with negative expression (55.6 and 45.5%, respectively) (P=0.013 and 0.036, respectively). P-gp was also found to be an independent prognostic marker of 2-year survival rate by logistic regression analysis (B=-2.76, P=0.061). Results of this study suggest that P-gp is a prognostic marker of GBC and the detection of P-gp and GST-π may contribute to the prognosis of GBC and the application of chemotherapy as a therapeutic treatment.
authors: General Surgery Department, GaoXin Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710075, P.R. China.
authors: Qing-Jiu
authors: QJ
authors: Ma
authors: General Surgery Department, GaoXin Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710075, P.R. China.
authors: Yu-Cun
authors: YC
authors: Zhang
authors: Hepatobiliary Department, First Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710061, P.R. China.
authors: Jing-Sen
authors: JS
authors: Shi
authors: General Surgery Department, GaoXin Hospital of Xi'an Jiao Tong University, Xi'an, Shaanxi 710075, P.R. China.
authors: Guo-Cai
authors: GC
authors: Li
keywords: P-glycoprotein; gallbladder cancer; glutathione S-transferase; metastasis; prognosis