title: Establishment and comparison of two reliable hyperkinetic pulmonary hypertension models in rabbits.
abstract: OBJECTIVE
  We sought to explore and create a reliable, convenient, and economic hyperkinetic pulmonary artery hypertension (PAH) model and confirm the exact time of establishing a reversible or irreversible model to serve as a platform for future studies.
  
  
  METHODS
  We used a common carotid artery and jugular vein shunt with an anastomosis and cuff to create a hyperkinetic PAH model in rabbits. At 1, 2, 3, 6, and 12 months postoperatively, the systolic pressure, mean pulmonary arterial pressure, and mean arterial pressure were measured by catheterization and the right ventricle hypertrophy index was calculated. Pathologic changes in the small pulmonary arteries were observed with hematoxylin and eosin staining, and the Heath-Edwards classification system was used to evaluate PAH.
  
  
  RESULTS
  The anastomosis and cuff graft groups both increased in systolic pressure, mean pulmonary arterial pressure (P<.05), and right ventricle hypertrophy index (P<.05). However, the anastomosis method resulted in a lower mortality rate, greater patency, and overall success rate compared with the cuff graft method (P<.05). Furthermore, from the observed pathologic changes and the Heath-Edwards classification system, a reversible and an irreversible PAH model was established at 3 and 6 months postoperatively, respectively.
  
  
  CONCLUSIONS
  The common carotid artery and jugular vein anastomosis method is a stable hyperkinetic PAH model in rabbits. Reversible and irreversible PAH models were established at 3 and 6 months postoperatively, respectively.
authors: Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
authors: Chuanzhen
authors: C
authors: Liu
authors: Department of General Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
authors: Zhibo
authors: Z
authors: Yan
authors: Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
authors: Changcun
authors: C
authors: Fang
authors: Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
authors: Guangqing
authors: G
authors: Cao
authors: Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
authors: Biao
authors: B
authors: Wang
authors: Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.
authors: Sijie
authors: S
authors: Li
authors: Department of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China. Electronic address: shumingwu001@126.com.
authors: Shuming
authors: S
authors: Wu
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D062186:Arterial Pressure; D019917:Blood Vessel Prosthesis Implantation; D017536:Carotid Artery, Common / Q000503:physiopathology / Q000601:surgery*; D002407:Catheterization, Swan-Ganz; D004195:Disease Models, Animal; D018450:Disease Progression; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D017380:Hypertrophy, Right Ventricular / Q000209:etiology / Q000503:physiopathology; D007601:Jugular Veins / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D011651:Pulmonary Artery / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits; D013997:Time Factors; D014654:Vascular Patency; D066253:Vascular Remodeling