title: Small-fibre neuropathies and skin: news and perspectives for dermatologists.
abstract: Small-fibre neuropathies (SFNs) can be defined as diseases of small nerve fibres. Because their symptoms are mainly located in the skin in the initial stages, dermatologists may frequently be confronted with these diseases. Moreover, skin biopsies and the subsequent measurement of intraepidermal nerve fibre density have become a widely accepted technique to investigate the structural integrity of small nerve fibres. The pathogenesis of injury to small nerve fibres is poorly understood. It probably depends on the cause. SCN9A-gene variants have been reported. Diabetes mellitus is one of the main causes of SFNs. Some causes of SFNs are very well-known to dermatologists: Gougerot-Sjögren syndrome, lupus, sarcoidosis and Fabry disease. We also discuss erythermalgia, prurigo nodularis, nummular eczema, burning mouth syndrome and sensitive skin as SFNs.
authors: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France, Breton Competence Centre of Rare Neuro-Muscular Diseases and Neuropathies with Cutaneous-Mucosal Symptoms, Brest, France, Department of dermatology.
authors: Laurent
authors: L
authors: Misery
authors: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France, Department of odontology.
authors: Céline
authors: C
authors: Bodere
authors: Breton Competence Centre of Rare Neuro-Muscular Diseases and Neuropathies with Cutaneous-Mucosal Symptoms, Brest, France, Department of clinical neurophysiology.
authors: Steeve
authors: S
authors: Genestet
authors: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France, Breton Competence Centre of Rare Neuro-Muscular Diseases and Neuropathies with Cutaneous-Mucosal Symptoms, Brest, France, Department of neurology, Armed Forces Instruction Hospital Clermont-Tonnerre, Brest, France.
authors: Fabien
authors: F
authors: Zagnoli
authors: University of Western Brittany, Laboratory of Neurosciences of Brest, Brest, France, Breton Competence Centre of Rare Neuro-Muscular Diseases and Neuropathies with Cutaneous-Mucosal Symptoms, Brest, France, Department of pathology, University Hospital of Brest, 29609 Brest, France.
authors: Pascale
authors: P
authors: Marcorelles
mesh_terms: D003880:Dermatology; D003937:Diagnosis, Differential; D004916:Erythromelalgia / Q000150:complications / Q000175:diagnosis; D006801:Humans; D012871:Skin Diseases / Q000150:complications / Q000175:diagnosis
keywords: Fabry disease; Gougerot-Sjögren syndrome; PGP9.5; burning mouth syndrome; erythermalgia; nerve; pruritus; sarcoidosis; sensitive skin; small-fibre neuropathy