title: Increased activation in Broca's area after cognitive remediation in schizophrenia.
abstract: Functional magnetic resonance imaging (fMRI) was used to measure changes in cerebral activity in patients with schizophrenia after participation in the Cognitive Remediation Program for Schizophrenia and other related disorders (RECOS). As RECOS therapists make use of problem-solving and verbal mediation techniques, known to be beneficial in the rehabilitation of dysexecutive syndromes, we expected an increased activation of frontal areas after remediation. Executive functioning and cerebral activation during a covert verbal fluency task were measured in eight patients with schizophrenia before (T1) and after (T2) 14 weeks of RECOS therapy. The same measures were recorded in eight patients with schizophrenia who did not participate in RECOS at the same intervals of time (TAU group). Increased activation in Broca's area, as well as improvements in performance of executive/frontal tasks, was observed after cognitive training. Metacognitive techniques of verbalization are hypothesized to be the main factor underlying the brain changes observed in the present study.
authors: Département de Psychiatrie, Centre Hospitalier Universitaire Vaudois (DP-CHUV), Lausanne, Switzerland. Electronic address: Pascal.Vianin@chuv.ch.
authors: Pascal
authors: P
authors: Vianin
authors: Département de Psychiatrie, Centre Hospitalier Universitaire Vaudois (DP-CHUV), Lausanne, Switzerland.
authors: Sébastien
authors: S
authors: Urben
authors: Centre des Neurosciences Psychiatriques (DP-CHUV), Lausanne, Switzerland; Brain Mind Institute, EPFL, Lausanne, Switzerland.
authors: Pierre
authors: P
authors: Magistretti
authors: Département de Psychiatrie, Centre Hospitalier Universitaire Vaudois (DP-CHUV), Lausanne, Switzerland; Centre des Neurosciences Psychiatriques (DP-CHUV), Lausanne, Switzerland.
authors: Pierre
authors: P
authors: Marquet
authors: Centre d'Imagerie Biomédicale (CIBM), CHUV Unit, Department of Radiology, Centre Hospitalier Universitaire Vaudois, and University of Lausanne, Switzerland.
authors: Eleonora
authors: E
authors: Fornari
authors: Département de Psychiatrie, Centre Hospitalier Universitaire Vaudois (DP-CHUV), Lausanne, Switzerland.
authors: Laure
authors: L
authors: Jaugey
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology; D003071:Cognition; D015928:Cognitive Behavioral Therapy; D056344:Executive Function; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D012565:Schizophrenic Psychology; D016037:Single-Blind Method; D016896:Treatment Outcome
keywords: Executive function; Frontal area; Functional magnetic resonance imaging; Verbal fluency; Verbalization