title: Differential modulatory effects of morphine on acute and chronic stress induced neurobehavioral and cellular markers in rats.
abstract: The present study evaluated the effects of morphine treatments on elevated plus maze test parameters, oxidative stress markers and Hsp70 expression in normal and stressed rats. Acute and chronic stress caused neurobehavioral suppression, altered prooxidant-antioxidant balance and increased Hsp70 expression in brain homogenates in a differential manner. Morphine (1 and 5mg/kg) attenuated RS induced anxiogenesis, changes in MDA and GSH but further enhanced Hsp70 expression. Similar anxiolytic and Hsp70 enhancing effects were seen after morphine in normal rats (no RS). Exposure to chronic RS did not elicit any appreciable neurobehavioral response in EPM but enhanced MDA, lowered GSH and exaggerated the Hsp70 expression. Pretreatment with morphine did not affect the neurobehavioral response to chronic RS, but reverted the GSH and Hsp70 expression. The results suggest that morphine differentially influences acute and chronic stress induced changes in anxiety behavior and complex interactions between oxidative stress markers and Hsp70 expression which may contribute to these effects.
authors: Department of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India.
authors: Jagdish C
authors: JC
authors: Joshi
authors: Department of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India.
authors: Arunabha
authors: A
authors: Ray
authors: Department of Pharmacology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110007, India. Electronic address: kavgul2002@yahoo.com.
authors: Kavita
authors: K
authors: Gulati
mesh_terms: D000208:Acute Disease; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002908:Chronic Disease; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D009020:Morphine / Q000494:pharmacology / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000188:drug therapy* / Q000378:metabolism* / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D018840:HSP70 Heat-Shock Proteins; D009020:Morphine
keywords: Anxiety; Hsp70 (PubChem CID:5461444); Hsp70 CID: 5461444; Morphine (PubChem CID:5288826); Morphine CID: 5288826; Oxidative stress; Restraint stress