title: Molecular evidence of stress-induced acute heart injury in a mouse model simulating posttraumatic stress disorder.
abstract: Posttraumatic stress disorder (PTSD) is a common condition induced by life-threatening stress, such as that experienced by soldiers under battlefield conditions. Other than the commonly recognized behavioral and psychological dysfunction, epidemiological studies have also revealed that PTSD patients have a higher risk of other diseases, such as cardiovascular disorders. Using a PTSD mouse model, we investigated the longitudinal transcriptomic changes in heart tissues after the exposure to stress through intimidation. Our results revealed acute heart injury associated with the traumatic experience, reflecting the underlying biological injury processes of the immune response, extracellular matrix remodeling, epithelial-to-mesenchymal cell transitions, and cell proliferation. Whether this type of injury has any long-term effects on heart function is yet to be determined. The differing responses to stress leading to acute heart injury in different inbred strains of mice also suggest that this response has a genetic as well as an environmental component. Accordingly, the results from this study suggest a molecular basis for the observed higher risk of cardiovascular disorders in PTSD patients, which raises the likelihood of cardiac dysfunction induced by long-term stress exposures.
authors: Institute for Systems Biology, Seattle, WA 98109.
authors: Ji-Hoon
authors: JH
authors: Cho
authors: Inyoul
authors: I
authors: Lee
authors: Rasha
authors: R
authors: Hammamieh
authors: Kai
authors: K
authors: Wang
authors: David
authors: D
authors: Baxter
authors: Kelsey
authors: K
authors: Scherler
authors: Alton
authors: A
authors: Etheridge
authors: Alena
authors: A
authors: Kulchenko
authors: Aarti
authors: A
authors: Gautam
authors: Seid
authors: S
authors: Muhie
authors: Nabarun
authors: N
authors: Chakraborty
authors: David J
authors: DJ
authors: Galas
authors: Marti
authors: M
authors: Jett
authors: Leroy
authors: L
authors: Hood
mesh_terms: D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D051379:Mice; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D046228:Microarray Analysis; D009205:Myocarditis / Q000209:etiology* / Q000378:metabolism*; D013313:Stress Disorders, Post-Traumatic / Q000209:etiology / Q000503:physiopathology*; D013315:Stress, Psychological / Q000150:complications* / Q000276:immunology; D049490:Systems Biology; D059467:Transcriptome / Q000502:physiology*
chemical_list: C547014:MIRN29 microRNA, mouse; D035683:MicroRNAs
keywords: microRNA; systems biology; transcriptome