title: Application of liquisolid technology for enhancing solubility and dissolution of rosuvastatin.
abstract: OBJECTIVE
  Rosuvastatin is a poorly water soluble drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. Hence it is necessary to increase the solubility of the Rosuvastatin.
  
  
  METHODS
  Several liquisolid tablets formulations containing various drug concentrations in liquid medication (ranging from 15% to 25% w/w) were prepared. The ratio of Avicel PH 102 (carrier) to Aerosil 200 (coating powder material) was kept 10, 20, 30. The prepared liquisolid systems were evaluated for their flow properties and possible drug-excipient interactions by Infrared spectra (IR) analysis, differential scanning calorimetry (DSC) and X- ray powder diffraction (XRPD).
  
  
  RESULTS
  The liquisolid system showed acceptable flow properties. The IR and DSC studies demonstrated that there is no significant interaction between the drug and excipients. The XRPD analysis confirmed formation of a solid solution inside the compact matrix. The tabletting properties of the liquisolid compacts were within the acceptable limits. Liquisolid compacts demonstrated significantly higher drug release rates than those of conventional and marketed tablet due to increasing wetting properties and surface area of the drug.
  
  
  CONCLUSIONS
  This study shows that liquisolid technique is a promising alternative for improvement of the dissolution rate of water insoluble drug.
authors: Department of Pharmaceutics, Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India-411044.
authors: Pavan Ram
authors: PR
authors: Kamble
authors: Department of Pharmaceutics, Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India-411044.
authors: Karimunnisa Sameer
authors: KS
authors: Shaikh
authors: Department of Pharmaceutics, Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India-411044.
authors: Pravin Digambar
authors: PD
authors: Chaudhari
keywords: Dissolution rate; Excipient ratio; Liquid load factor; Liquisolid compacts; Rosuvastatin calcium; Tablets