title: In vitro activity of fosfomycin in combination with linezolid against clinical isolates of methicillin-resistant Staphylococcus aureus.
abstract: The objective of this paper was to investigate the in vitro effects of fosfomycin combined with linezolid against methicillin-resistant Staphylococcus aureus (MRSA). A total of 102 MRSA isolates isolated from clinical specimens of human infections from three hospitals in China were studied. The microdilution checkerboard method was used to determine whether combinations act synergistically against these isolates. The susceptibility results for fosfomycin and linezolid were interpreted according to the guidelines of the Clinical and Laboratory Standards Institute. Synergy and indifference were defined as a fractional inhibitory concentration index of ⩽0.5 and >0.5 but ⩽4, respectively. The combination of fosfomycin and linezolid demonstrated the following interactions: 98.04% (100/102) synergism; 1.96% (2/102) indifference; no antagonism was seen. Thus, the combination between fosfomycin and linezolid shows synergism for most of the MRSA isolates tested in this study. If these findings are confirmed in further in vitro or in vivo studies, the above combination could be tested clinically for difficulty to treat MRSA infections, particularly those warranting prolonged oral therapy.
authors: Department of Pharmacy, The Chinese PLA 305 Hospital, Beijing, China.
authors: Yu
authors: Y
authors: Xu-hong
authors: 1] Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece [2] Department of Medicine, Henry Dunant Hospital, Athens, Greece [3] Department of Medicine, Tufts University School of Medicine, Boston, MA, USA.
authors: Matthew E
authors: ME
authors: Falagas
authors: The Chinese PLA General Hospital, Pharmaceutical Administration, Beijing, China.
authors: Wang
authors: W
authors: Dong
authors: Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece.
authors: Drosos E
authors: DE
authors: Karageorgopoulos
authors: Department of Pharmacy, Skin Disease Prevention and Control Hospital, Qanzhou, Fujian, China.
authors: Lin
authors: L
authors: De-feng
authors: Department of Clinical Pharmacology, The Chinese PLA General Hospital, Beijing, China.
authors: Wang
authors: W
authors: Rui
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D005578:Fosfomycin / Q000494:pharmacology*; D006801:Humans; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000382:microbiology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D023303:Oxazolidinones; D005578:Fosfomycin; D000069349:Linezolid