title: Impact of a complex nutraceutical supplement on primary tumour formation and metastasis in Trp53+/- cancer-prone mice.
abstract: A complex dietary supplement designed to impact multiple mechanisms associated with aging and cancer reduced overall tumorigenesis in cancer-prone heterozygous Trp53+/- mice by ~30% (P < 0.018). Carcinomas were reduced by 67% (P < 0.006). Remarkably, metastasis (a leading cause of cancer mortality) was undetectable in treated animals (P < 0.004), and the occurrence of multiple primary tumours was reduced by 74% (P < 0.012). Reduction of pulmonary adenocarcinoma by 62% (P < 0.021) was of particular note given that lung cancer is the second leading cause of death in humans. Tumours showed pronounced age-related expression in untreated animals older than 600 days. Benefits of treatment only emerged in these later ages, suggesting that the supplement acted on mechanisms common to aging and cancer. The supplement was administered daily on bagel bits that were usually eaten within minutes by the mice. Although longevity was not statistically different between treatments, longevity was strongly related to the compliance of mice in eating the supplement. Linear regression revealed a strong positive relationship between the proportion of supplement eaten and the longevity of mice within the treatment group (P < 0.0001).
authors: Department of Biology and.
authors: Vadim
authors: V
authors: Aksenov
authors: Douglas
authors: D
authors: Boreham
authors: C David
authors: CD
authors: Rollo
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000517:prevention & control; D000077192:Adenocarcinoma of Lung; D000818:Animals; D019587:Dietary Supplements / Q000032:analysis; D016158:Genes, p53; D006801:Humans; D016014:Linear Models; D008136:Longevity; D008175:Lung Neoplasms / Q000235:genetics / Q000517:prevention & control; D008297:Male; D051379:Mice; D057507:Mice, 129 Strain; D018345:Mice, Knockout; D009362:Neoplasm Metastasis / Q000235:genetics / Q000517:prevention & control; D009374:Neoplasms, Experimental / Q000235:genetics / Q000517:prevention & control* / Q000556:secondary; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000517:prevention & control; D018384:Oxidative Stress; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency* / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53