title: [Detection of serum endothelial cell specific molecule 1 in gastric cancer patients and its clinical significance].
abstract: OBJECTIVE
  To investigate the expression of serum endothelial cell specific molecule 1 (ESM-1) in gastric cancer and to evaluate the effect of serum ESM-1 as a potential serum biomarker.
  
  
  METHODS
  Serum ESM-1 was detected by enzyme-linked immunosorbent assay (ELISA) and CEA, CA19.9, CA72.4 were detected by electrochemiluminescence immunoassay (ECLIA) in 102 patients with gastric cancer preoperatively. At the same time, serum ESM-1, CEA, CA19-9, CA72-4 in 41 healthy adults volunteers were detected with the same method. In addition, the follow-up data of all the patients were collected.
  
  
  RESULTS
  Compared to healthy volunteers, the serum ESM-1 level in gastric cancer patients increased (P<0.01). The sensitivity and specificity of serum ESM-1 were 73.9% and 51.2% respectively. In contrast, the sensitivities of CEA, CA19-9 and CA72-4 were only 16.1%, 18.3% and 23.2% respectively. High level of serum ESM-1 indicated poor outcomes (P<0.05).
  
  
  CONCLUSIONS
  Serum ESM-1 increases in the peripheral blood of the gastric cancer patients. It may be a potential serum marker to help diagnosis and prediction of prognosis of gastric cancer patients.
authors: Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Cancer Surgery, Peking University Cancer Hospital and Institute, Beijing 100142, China. jiafuj@hotmail.com.
authors: Wei
authors: W
authors: Sun
authors: Lianhai
authors: L
authors: Zhang
authors: Xiaojing
authors: X
authors: Cheng
authors: Xiaohong
authors: X
authors: Wang
authors: Xiaofang
authors: X
authors: Xing
authors: Hong
authors: H
authors: Du
authors: Jiafu
authors: J
authors: Ji
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D011509:Proteoglycans / Q000097:blood*; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans