title: The importance of being dispersed: A ranking of diffusion MRI models for fibre dispersion using in vivo human brain data.
abstract: In this work we compare parametric diffusion MRI models which explicitly seek to explain fibre dispersion in nervous tissue. These models aim at providing more specific biomarkers of disease by disentangling these structural contributions to the signal. Some models are drawn from recent work in the field; others have been constructed from combinations of existing compartments that aim to capture both intracellular and extracellular diffusion. To test these models we use a rich dataset acquired in vivo on the corpus callosum of a human brain, and then compare the models via the Bayesian Information Criteria. We test this ranking via bootstrapping on the data sets, and cross-validate across unseen parts of the protocol. We find that models that capture fibre dispersion are preferred. The results show the importance of modelling dispersion, even in apparently coherent fibres.
authors: CMIC, Dept. Computer Science and Dept. Medical Physics and Bioengineering, University College London, United Kingdom. uran.ferizi.10@ucl.ac.uk
authors: Uran
authors: U
authors: Ferizi
authors: NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, United Kingdom.
authors: Torben
authors: T
authors: Schneider
authors: CMIC, Dept. Computer Science and Dept. Medical Physics and Bioengineering, University College London, United Kingdom.
authors: Maira
authors: M
authors: Tariq
authors: NMR Research Unit, Department of Neuroinflammation, Institute of Neurology, University College London, United Kingdom.
authors: Claudia A M
authors: CA
authors: Wheeler-Kingshott
authors: CMIC, Dept. Computer Science and Dept. Medical Physics and Bioengineering, University College London, United Kingdom.
authors: Hui
authors: H
authors: Zhang
authors: CMIC, Dept. Computer Science and Dept. Medical Physics and Bioengineering, University College London, United Kingdom.
authors: Daniel C
authors: DC
authors: Alexander
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D003337:Corpus Callosum / Q000033:anatomy & histology*; D056324:Diffusion Tensor Imaging / Q000379:methods*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods; D008953:Models, Anatomic; D008959:Models, Neurological; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity