title: Outbreak caused by NDM-1- and RmtB-producing Escherichia coli in Bulgaria.
abstract: Twelve consecutive carbapenem-resistant Escherichia coli isolates were recovered from patients (infection or colonization) hospitalized between March and September 2012 in different units at a hospital in Bulgaria. They all produced the carbapenemase NDM-1 and the extended-spectrum-β-lactamase CTX-M-15, together with the 16S rRNA methylase RmtB, conferring high-level resistance to all aminoglycosides. All those isolates were clonally related and belonged to the same sequence type, ST101. In addition to being the first to identify NDM-producing isolates in Bulgaria, this is the very first study reporting an outbreak of NDM-1-producing E. coli in the world.
authors: Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland.
authors: Laurent
authors: L
authors: Poirel
authors: Encho
authors: E
authors: Savov
authors: Arzu
authors: A
authors: Nazli
authors: Angelina
authors: A
authors: Trifonova
authors: Iva
authors: I
authors: Todorova
authors: Ivanka
authors: I
authors: Gergova
authors: Patrice
authors: P
authors: Nordmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002031:Bulgaria; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D001618:beta-Lactamases / Q000187:drug effects / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1