title: Quantitative linkage for autism spectrum disorders symptoms in attention-deficit/hyperactivity disorder: significant locus on chromosome 7q11.
abstract: We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.
authors: Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, j.nijmeijer@accare.nl.
authors: Judith S
authors: JS
authors: Nijmeijer
authors: Alejandro
authors: A
authors: Arias-Vásquez
authors: Nanda N J
authors: NN
authors: Rommelse
authors: Marieke E
authors: ME
authors: Altink
authors: Cathelijne J M
authors: CJ
authors: Buschgens
authors: Ellen A
authors: EA
authors: Fliers
authors: Barbara
authors: B
authors: Franke
authors: Ruud B
authors: RB
authors: Minderaa
authors: Joseph A
authors: JA
authors: Sergeant
authors: Jan K
authors: JK
authors: Buitelaar
authors: Pieter J
authors: PJ
authors: Hoekstra
authors: Catharina A
authors: CA
authors: Hartman
mesh_terms: D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000235:genetics* / Q000503:physiopathology; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D011795:Surveys and Questionnaires