title: Two new glycosides from the fruits of Forsythia suspense.
abstract: Two new glycosides suspensaside C (1) and 2,3,5,6-tetrahydro-jacaranone-4-O-β-D-glucopyranoside (2), together with four known compounds suspensaside A (3), rengynic acid-1'-O-β-D-glucopyranoside (4), forsythoside A (5), and rengynic acid (6), were isolated from the fruits of Forsythia suspense (Thunb.) Vahl. The structures of 1 and 2 were elucidated on the basis of chemical and spectral analysis, including 1D, 2D NMR analyses and HR-ESI-MS. All isolates were tested for their cytotoxicities against five human cancer cell lines (A549, Colo-205, Hep-3B, HL60, and KB). Compound 3 exhibited cytotoxicity against HL-60, Hep-3B, and A549 cancer cell lines.
authors: a School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University , Shenyang 110016 , China.
authors: Xin-Jia
authors: XJ
authors: Yan
authors: Xin-Yu
authors: XY
authors: Bai
authors: Qing-Bo
authors: QB
authors: Liu
authors: Shen
authors: S
authors: Liu
authors: Pin-Yi
authors: PY
authors: Gao
authors: Ling-Zhi
authors: LZ
authors: Li
authors: Shao-Jiang
authors: SJ
authors: Song
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002109:Caffeic Acids; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031657:Forsythia / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D005960:Glucosides; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D007624:KB Cells; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C000588513:2,3,5,6-tetrahydro-jacaranone-4-O-beta-D-glucopyranoside; D000972:Antineoplastic Agents, Phytogenic; D002109:Caffeic Acids; D004365:Drugs, Chinese Herbal; D005960:Glucosides; D006027:Glycosides; C000588512:suspensaside C; C037876:suspensaside; C058049:forsythiaside