title: Progenitor “Mycobacterium canettii” clone responsible for lymph node tuberculosis epidemic, Djibouti.
abstract: “Mycobacterium canettii,” an opportunistic human pathogen living in an unknown environmental reservoir, is the progenitor species from which Mycobacterium tuberculosis emerged. Since its discovery in 1969, most of the ≈70 known M. canettii strains were isolated in the Republic of Djibouti, frequently from expatriate children and adults. We show here, by whole-genome sequencing, that most strains collected from February 2010 through March 2013, and associated with 2 outbreaks of lymph node tuberculosis in children, belong to a unique epidemic clone within M. canettii. Evolution of this clone, which has been recovered regularly since 1983, may mimic the birth of M. tuberculosis. Thus, recognizing this organism and identifying its reservoir are clinically important.
authors: Yann
authors: Y
authors: Blouin
authors: Géraldine
authors: G
authors: Cazajous
authors: Céline
authors: C
authors: Dehan
authors: Charles
authors: C
authors: Soler
authors: Rithy
authors: R
authors: Vong
authors: Mohamed Osman
authors: MO
authors: Hassan
authors: Yolande
authors: Y
authors: Hauck
authors: Christian
authors: C
authors: Boulais
authors: Dina
authors: D
authors: Andriamanantena
authors: Christophe
authors: C
authors: Martinaud
authors: Émilie
authors: É
authors: Martin
authors: Christine
authors: C
authors: Pourcel
authors: Gilles
authors: G
authors: Vergnaud
mesh_terms: D000293:Adolescent; D000328:Adult; D053898:Biosynthetic Pathways; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D064112:Clustered Regularly Interspaced Short Palindromic Repeats; D015730:Djibouti / Q000453:epidemiology; D005260:Female; D016680:Genome, Bacterial; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009161:Mycobacterium / Q000145:classification* / Q000235:genetics / Q000378:metabolism; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D014388:Tuberculosis, Lymph Node / Q000453:epidemiology* / Q000382:microbiology*; D014805:Vitamin B 12 / Q000096:biosynthesis; D055815:Young Adult
chemical_list: D014805:Vitamin B 12