title: Assessing adherence factors in patients under topical treatment: development of the Topical Therapy Adherence Questionnaire (TTAQ).
abstract: Medication adherence rates strongly depend on favorable disease outcomes. It is known that medication adherence rates are lower for topical treatment than for systemic treatment. However, to date no validated instrument for the assessment of adherence factors in topical treatment is available. The aim of this study was to develop a new questionnaire to assess adherence risk factors in topical treatment. The development of the Topical Therapy Adherence Questionnaire (TTAQ) and Patient Preference Questionnaire (PPQ) was based on a systematic literature review, and qualitative patient focus interviews and expert focus groups' input. The psychometric properties and comprehensibility of the TTAQ and PPQ were assessed in a feasibility study with 59 psoriasis patients. Our first preliminary results indicate that the TTAQ and PPQ are psychometrically sound and reliable measures for the assessment of factors influencing topical treatment adherence. The questionnaires are currently being further developed and various parameters (e.g., time point of assessment) are currently being tested in an exploratory pilot study with ca. 2,000 psoriasis patients receiving topical treatment in a European clinical trial. The use of the final versions of TTAQ and PPQ in clinical practice may facilitate the early identification of specific non-adherence factors in patients under topical treatment, which could enable designing and applying adherence-enhancing interventions according to the patient's individual needs.
authors: SCIderm GmbH, Drehbahn 1-3, 20354, Hamburg, Germany.
authors: Ina
authors: I
authors: Zschocke
authors: Ulrich
authors: U
authors: Mrowietz
authors: Annett
authors: A
authors: Lotzin
authors: Eleni
authors: E
authors: Karakasili
authors: Kristian
authors: K
authors: Reich
mesh_terms: D000279:Administration, Cutaneous; D032882:Comprehension; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005240:Feasibility Studies; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D055118:Medication Adherence; D057240:Patient Preference; D011565:Psoriasis / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D011594:Psychometrics; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents