title: Rhodium-catalyzed C-H alkynylation of arenes at room temperature.
abstract: The rhodium(III)-catalyzed ortho C-H alkynylation of non-electronically activated arenes is disclosed. This process features a straightforward and highly effective protocol for the synthesis of functionalized alkynes and represents the first example of merging a hypervalent iodine reagent with rhodium(III) catalysis. Notably, this reaction proceeds at room temperature, tolerates a variety of functional groups, and more importantly, exhibits high selectivity for monoalkynylation.
authors: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore).
authors: Chao
authors: C
authors: Feng
authors: Teck-Peng
authors: TP
authors: Loh
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013696:Temperature
chemical_list: D000480:Alkynes; D001555:Benzene Derivatives; D009942:Organometallic Compounds; D012238:Rhodium
keywords: CH activation; alkynes; cross-coupling; iodine; rhodium