title: Burkholderia pyrrocinia in cystic fibrosis lung transplantation: a case report.
abstract: Infection with Burkholderia species is typically considered a contraindication leading to transplantation in cystic fibrosis (CF). However, the risks posed by different Burkholderia species on transplantation outcomes are poorly defined. We present the case of a patient with CF who underwent lung transplantation due to a severe respiratory failure from chronic airways infection with Burkholderia pyrrocinia (B. cepacia genomovar IX) and pan-resistant Pseudomonas aeruginosa. The postoperative course was complicated by recurrent B. pyrrocinia infections, ultimately lea ding to uncontrollable sepsis and death. This is the first case report in CF of Burkholderia pyrrocinia infection and lung transplantation, providing further evidence of the high risk nature of the Burkholderia species.
authors: Department of Pediatrics and Pediatric Neurology, Cystic Fibrosis Center, Sapienza University of Rome, Rome, Italy. Electronic address: danielasavi1@virgilio.it.
authors: D
authors: D
authors: Savi
authors: Department of Pediatrics and Pediatric Neurology, Cystic Fibrosis Center, Sapienza University of Rome, Rome, Italy.
authors: R Valerio
authors: RV
authors: De Biase
authors: Pediatric Department, Cystic Fibrosis Center, Institute for Maternal and Child Health - IRCCS "Burlo Garofolo," University of Trieste, Trieste, Italy.
authors: A
authors: A
authors: Amaddeo
authors: Department of Thoracic Surgery, Sapienza University of Rome, Rome, Italy.
authors: M
authors: M
authors: Anile
authors: Department of Thoracic Surgery, Sapienza University of Rome, Rome, Italy.
authors: F
authors: F
authors: Venuta
authors: Department of Anaesthesiology and Intensive Care, Sapienza University of Rome, Rome, Italy.
authors: F
authors: F
authors: Ruberto
authors: Department of Cystic Fibrosis, Royal Brompton Hospital and Imperial College, London, United Kingdom.
authors: N
authors: N
authors: Simmonds
authors: Department of Pediatrics and Pediatric Neurology, Cystic Fibrosis Center, Sapienza University of Rome, Rome, Italy.
authors: G
authors: G
authors: Cimino
authors: Department of Pediatrics and Pediatric Neurology, Cystic Fibrosis Center, Sapienza University of Rome, Rome, Italy.
authors: S
authors: S
authors: Quattrucci
mesh_terms: D000293:Adolescent; D019117:Burkholderia; D019121:Burkholderia Infections / Q000000981:diagnostic imaging / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D003550:Cystic Fibrosis / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000601:surgery*; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D011184:Postoperative Period; D012306:Risk; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D002097:C-Reactive Protein