title: Cardiometabolic and traditional cardiovascular risk factors and their potential impact on macrovascular and microvascular function: preliminary data.
abstract: We studied the relationship between cardiovascular status (CV) and risk factor numbers, macrovascular (flow mediated dilatation: FMD) and microvascular function using near-infrared spectroscopy (NIRS) in adults with different CV status. Seventy adults with different CV status (27 controls, 18 metabolic syndrome (MetS) and 25 coronary heart disease (CHD) patients) underwent a 5-min forearm arterial occlusion in supine position. High-resolution ultrasound examination of the brachial artery was performed during 1 minute at rest and 45 to 120 seconds after cuff release. Oxy, de-oxy and total hemoglobin signals (O2Hb, HHb and tHb) were measured continuously with NIRS on brachio-radialis muscle. FMD was reduced in CHD patients (P<0.05) compared to controls. Max. amplitude of O2Hb and Hmax of tHb were reduced (P<0.05) in MetS patients vs. controls. Post-deflation area under the curve (A.U.C) of O2Hb was lower in CHD (P<0.01) patients vs. controls and MetS patients. Independent predictors of microvascular function (A.U.C of O2Hb) were abdominal obesity and LDL-cholesterol whereas macrovascular function (FMD) was predicted by CV status. Only A.U.C of O2Hb related to CV risk numbers whereas FMD was not. Although macro and microvascular function were impaired in MetS and CHD patients, microvascular function was more strongly related to CV risk factors.
authors: Cardiovascular Prevention and Rehabilitation Centre (Centre ÉPIC), Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: Mathieu
authors: M
authors: Gayda
authors: Cardiovascular Prevention and Rehabilitation Centre (Centre ÉPIC), Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: Martin
authors: M
authors: Juneau
authors: Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: Jean-Claude
authors: JC
authors: Tardif
authors: Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: François
authors: F
authors: Harel
authors: Biostatistics department, Montreal Heart Institute Coordinating Centre and Université de Montréal, Montreal, Quebec, Canada.
authors: Sylvie
authors: S
authors: Levesque
authors: Cardiovascular Prevention and Rehabilitation Centre (Centre ÉPIC), Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada Research Center, Montreal Heart Institute and Université de Montréal, Montreal, Quebec, Canada Department of Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
authors: Anil
authors: A
authors: Nigam
mesh_terms: D000328:Adult; D000368:Aged; D001916:Brachial Artery / Q000503:physiopathology; D003327:Coronary Disease / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D055806:Microvessels / Q000503:physiopathology*; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000032:analysis / Q000378:metabolism; D012307:Risk Factors; D014664:Vasodilation
chemical_list: D010108:Oxyhemoglobins
keywords: Macrovascular function; cardiovascular risk factors; microvascular reactivity