title: "Atypical" regulation of Hedgehog-dependent cancers.
abstract: Growing evidence indicates targeting PKCι may be effective in treating Hedgehog-dependent cancers. In this issue of Cancer Cell, Justilien and colleagues present the surprising finding that PKCι promotes Hedgehog ligand production and lung squamous cell carcinoma growth through SOX2, rather than the canonical transcription factor GLI.
authors: Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors: Scott X
authors: SX
authors: Atwood
authors: Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: oro@stanford.edu.
authors: Anthony E
authors: AE
authors: Oro
mesh_terms: D000217:Acyltransferases / Q000378:metabolism*; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008175:Lung Neoplasms / Q000473:pathology*; D011493:Protein Kinase C / Q000378:metabolism*; D055748:SOXB1 Transcription Factors / Q000378:metabolism*; D000099293:Protein Kinase C-lambda
chemical_list: D000217:Acyltransferases; D007527:Isoenzymes; D011493:Protein Kinase C; D055748:SOXB1 Transcription Factors; D000099293:Protein Kinase C-lambda; C527782:SOX2 protein, human; C105599:HHAT protein, human