title: BMI and the risk of colorectal adenoma in African-Americans.
abstract: OBJECTIVE
  Obesity is associated with the activation of the molecular pathways that increase the risk of colorectal cancer. Increasing body mass index may accelerate the development of adenomatous polyps, the antecedent lesion of colorectal cancer. The aim of this study was to assess the BMI effect on the risk of colonic polyp and adenoma in African-American.
  
  
  METHODS
  The records of 923 patients who underwent colonoscopy were examined. Demographic and clinical data were collected before colonoscopy. Polyp and adenoma diagnosis were confirmed by pathology examinations.
  
  
  RESULTS
  Overall, 43% of the patients were male, median age was 57 years and 77% had BMI ≥ 25.0 kg/m(2) . The frequency of colorectal polyps and adenomas were 61 and 35%, respectively. BMI ≥ 25.0 (OR = 1.61, 95% CI = 1.14-2.26), smoking (OR = 1.61, 95% CI = 1.15-2.26) and history of colon polyps (OR = 1.64, 95% CI = 1.09-2.47) were associated with higher risk of colon polyp. BMI ≥ 25.0 (OR = 1.81, 95% CI = 1.24-2.62), age (OR = 1.04, 95% CI = 1.02-2.05 for each year), male gender (OR = 1.38, 95% CI = 1.02-1.86), and smoking (OR = 1.73, 95% CI = 1.23-2.42) were associated with higher risk of colon adenoma.
  
  
  CONCLUSIONS
  Male and overweight African-Americans are at higher risk of colorectal adenoma. The findings of this study could be applied for risk stratification and modifying the colorectal cancer prevention including screening guideline in African Americans.
authors: Department of Medicine and Cancer Center, Howard University College of Medicine, 2041 Georgia Avenue, N.W., Washington, District Columbia, 20060, USA.
authors: Hassan
authors: H
authors: Ashktorab
authors: Mansour
authors: M
authors: Paydar
authors: Shahla
authors: S
authors: Yazdi
authors: Hassan Hassanzadeh
authors: HH
authors: Namin
authors: Andrew
authors: A
authors: Sanderson
authors: Rehana
authors: R
authors: Begum
authors: Mohammad
authors: M
authors: Semati
authors: Firoozeh
authors: F
authors: Etaati
authors: Edward
authors: E
authors: Lee
authors: Hassan
authors: H
authors: Brim
authors: Anteneh
authors: A
authors: Zenebe
authors: Gail
authors: G
authors: Nunlee-Bland
authors: Adeyinka O
authors: AO
authors: Laiyemo
authors: Mehdi
authors: M
authors: Nouraie
mesh_terms: D001741:Black or African American; D015992:Body Mass Index; D003111:Colonic Polyps / Q000175:diagnosis / Q000453:epidemiology*; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D050177:Overweight / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors