title: Use of shear wave elastography to differentiate benign and malignant breast lesions.
abstract: OBJECTIVE
  We aimed to determine the correlations between the elasticity values of solid breast masses and histopathological findings to define cutoff elasticity values differentiating malignant from benign lesions.
  
  
  METHODS
  A total of 115 solid breast lesions of 109 consecutive patients were evaluated prospectively using shear wave elastography (SWE). Two orthogonal elastographic images of each lesion were obtained. Minimum, mean, and maximum elasticity values were calculated in regions of interest placed over the stiffest areas on the two images; we also calculated mass/fat elasticity ratios. Correlation of elastographic measurements with histopathological results were studied.
  
  
  RESULTS
  Eighty-three benign and thirty-two malignant lesions were histopathologically diagnosed. The minimum, mean, and maximum elasticity values, and the mass/fat elasticity ratios of malignant lesions, were significantly higher than those of benign lesions. The cutoff value was 45.7 kPa for mean elasticity (sensitivity, 96%; specificity, 95%), 54.3 kPa for maximum elasticity (sensitivity, 95%; specificity, 94%), 37.1 kPa for minimum elasticity (sensitivity, 96%; specificity, 95%), and 4.6 for the mass/fat elasticity ratio (sensitivity, 97%; specificity, 95%).
  
  
  CONCLUSIONS
  SWE yields additional valuable quantitative data to ultrasonographic examination on solid breast lesions. SWE may serve as a complementary tool for diagnosis of breast lesions. Long-term clinical studies are required to accurately select lesions requiring biopsy.
authors: From the Departments of Radiology İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey. fahrettinkilic@hotmail.com.
authors: Deniz
authors: D
authors: Çebi Olgun
authors: Bora
authors: B
authors: Korkmazer
authors: Fahrettin
authors: F
authors: Kılıç
authors: Atilla Süleyman
authors: AS
authors: Dikici
authors: Mehmet
authors: M
authors: Velidedeoğlu
authors: Fatih
authors: F
authors: Aydoğan
authors: Fatih
authors: F
authors: Kantarcı
authors: Mehmet Halit
authors: MH
authors: Yılmaz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods*