title: Effect of relative weight group change on nuclear magnetic resonance spectroscopy derived lipoprotein particle size and concentrations among adolescents.
abstract: OBJECTIVE
  To examine whether longitudinal changes in relative weight category (as indicated by change in body mass index [BMI] classification group) were associated with changes in nuclear magnetic resonance (NMR)-derived lipoprotein particles among US youth.
  
  
  METHODS
  Secondary analysis of data from a clustered randomized controlled trial. BMI and fasting blood samples were obtained from 2069 participants at the start of the 6th grade and end of the 8th grade. BMI was categorized as normal weight, overweight, or obese at both time points. Lipoprotein particle profiles were measured with NMR spectroscopy at both time points. Regression models were used to examine changes in relative weight group and change in lipoprotein variables.
  
  
  RESULTS
  A total of 38% of participants changed relative weight category (BMI group) during the 2.5-year study period. Low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (HDL) cholesterol decreased almost universally, but more with improved BMI category. There were adverse effects on LDL size and total LDL particles, HDL size, and cholesterol for participants who remained obese or whose relative weight group worsened. Changes in relative category had no impact on HDL particles.
  
  
  CONCLUSIONS
  Improvement in relative weight group from 6th to 8th grade was associated with favorable changes in non-HDL cholesterol, very low-density lipoprotein size, LDL size, HDL size, and LDL particles but had no effect on HDL particles. Findings indicate that an improvement in relative weight group between 6th and 8th grade had an effect on NMR-derived particles sizes and concentrations among a large group of adolescents, which overrepresented low-income minorities.
authors: Center for Exercise, Nutrition & Health, School for Policy Studies, University of Bristol, Bristol, United Kingdom. Electronic address: russ.jago@bris.ac.uk.
authors: Russell
authors: R
authors: Jago
authors: Biostatistics Center, George Washington University, Rockville, MD.
authors: Kimberly L
authors: KL
authors: Drews
authors: LipoScience, Inc, Raleigh, NC.
authors: James D
authors: JD
authors: Otvos
authors: Center for Obesity Research and Education, Temple University, Philadelphia, PA.
authors: Gary D
authors: GD
authors: Foster
authors: University of Pittsburgh School of Medicine, Pittsburgh, PA.
authors: Marsha D
authors: MD
authors: Marcus
authors: University of North Carolina School of Medicine, Chapel Hill, NC.
authors: John B
authors: JB
authors: Buse
authors: School of Medicine & Health Sciences, George Washington University, Washington, DC; Children's National Medical Center, Washington, DC.
authors: Michele
authors: M
authors: Mietus-Snyder
authors: Children's Hospital of Philadelphia, Philadelphia, PA; Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA.
authors: Steven M
authors: SM
authors: Willi
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood / Q000737:chemistry; D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood / Q000737:chemistry*; D008078:Cholesterol, LDL / Q000097:blood / Q000737:chemistry*; D015243:Cholesterol, VLDL / Q000097:blood / Q000737:chemistry*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016014:Linear Models; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D050177:Overweight / Q000097:blood; D010316:Particle Size; D063766:Pediatric Obesity / Q000097:blood*; D013851:Thinness / Q000097:blood; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL