title: Repeated application of electroacupuncture ameliorates hyperglycemia in obese Zucker diabetic fatty rats.
abstract: Electroacupuncture (EA) was investigated for lowering the blood glucose (BG) in fasting male obese Zucker fatty diabetic (ZDF) rats aged 10-17 weeks. Anesthesia provided satisfactory chemical restraint to enable repeated EA. Animals in Groups 1, 2 and 3 were anesthetized on Days 1, 3, 5, 8, 10 and 12. Group 1 (n = 4) received no EA (controls), Group 2 (n = 4) EA at Zhongwan and Guanyuan acupoints, and Group 3 (n = 4) EA at both Zusanli acupoints. BG was measured at 10 and 20 minutes, and EA was applied for 30 minutes, after which BG was measured again. Group 2 had a significantly lower baseline BG at 20 minutes on Days 5, 8 and 12 and significantly less change in BG over 30 minutes on Days 3 and 5 than Group 1 (p < 0.05). Group 3 showed a significant decrease in the mean baseline BG compared to Group 1 in Week 1 (p < 0.05). Thus, repeated EA using Zhongwan and Guanyuan acupoints was effective in lowering the baseline BG and modulating the change in the BG in anesthetized animals.
authors: Department of Anatomy, University of Otago, Dunedin, New Zealand. Electronic address: phil.peplow@stonebow.otago.ac.nz.
authors: Philip V
authors: PV
authors: Peplow
authors: Department of Anatomy, University of Otago, Dunedin, New Zealand.
authors: Soo Min
authors: SM
authors: Han
mesh_terms: D018685:Anesthetics, Inhalation; D000818:Animals; D001786:Blood Glucose / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D015671:Electroacupuncture; D006221:Halothane; D006943:Hyperglycemia / Q000628:therapy*; D008297:Male; D051381:Rats; D011924:Rats, Zucker
chemical_list: D018685:Anesthetics, Inhalation; D001786:Blood Glucose; D006221:Halothane
keywords: Zucker rats; blood glucose; diabetes; electroacupuncture; male