title: [Association study of bronchial asthma with polymorphisms of IL-4 and IL-4R receptor genes].
abstract: OBJECTIVE
  To assess the association of polymorphisms of IL-4 gene (rs2243250, rs2243283) and IL-4R gene (rs1805012, rs1801275, rs1805010) with susceptibility to asthma among ethnic Chinese in Qingdao.
  
  
  METHODS
  For 400 asthma patients and 200 healthy subjects, above polymorphisms were detected with SnaPshot method.
  
  
  RESULTS
  For rs1805012, the frequency of TC genotype in the asthma group was significantly lower than the control group (8.8% vs. 15.5%, χ (2)= 6.498, P= 0.039), and so were the frequencies of TC+ CC genotypes (9.0% vs. 15.5%, χ (2) = 5.522, P= 0.019) and the C allele (4.6% vs. 7.7%, χ (2) = 4.729, P= 0.039). No significant difference was detected between the two groups in the frequency of the remaining four polymorphisms or the haplotypes formed by rs2243250 and rs2243283 (All P> 0.05).
  
  
  CONCLUSIONS
  This study has indicated that rs1805012 polymorphism of IL-4R gene is associated with asthma in ethnic Han Chinese from Qingdao region. TC+ CC genotypes have a protective role against asthma compared with TT genotype. However, polymorphisms of IL-4 gene are not associated with susceptibility to asthma.
authors: Department of Pneumonology, Qingdao Hiser Medical Center, Qingdao, Shandong 266033, P.R.China. at_mountain@163.com.
authors: Wenhua
authors: W
authors: Liang
authors: Zhaoshan
authors: Z
authors: Zhou
authors: Zhongqiang
authors: Z
authors: Ji
authors: Yanqing
authors: Y
authors: Wang
authors: Weilin
authors: W
authors: Xue
authors: Xiaoyan
authors: X
authors: Zhang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D001249:Asthma; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019948:Receptors, Interleukin-4 / Q000235:genetics*
chemical_list: C508598:IL4 protein, human; D019948:Receptors, Interleukin-4; D015847:Interleukin-4