title: Pilot randomized-control trial to assess the effect product sampling has on adherence using adapalene/benzoyl peroxide gel in acne patients.
abstract: BACKGROUND
  The treatment of acne can be difficult, with suboptimal adherence resulting in poor treatment outcomes.
  
  
  OBJECTIVE
  To determine whether demonstrating to patients how to properly apply a topical acne medication through the use of a sample product will improve adherence.
  
  
  METHODS
  Subjects with mild to moderate acne were instructed to use adapalene/benzoyl peroxide gel once daily for six weeks. Subjects were randomized into sample or no sample group. Sample group received a demonstration on how to apply the medication using a product sample. The primary outcome was median adherence, recorded using electronic monitoring, and secondary outcomes were efficacy measures including the Acne Global Assessment (AGA) and lesion counts and the Perceived Medical Condition Self-Management Scale (PMCSMS).
  
  
  RESULTS
  Data from 17 patients was collected and analyzed. Median adherence rates were 50% in the sample group and 35% in the no sample group (p=0.67). The median percent improvement in non-inflammatory lesions were 46% for the sample group and 33% for the no-sample group (p=0.10).
  
  
  CONCLUSIONS
  The small size of this pilot study limited the extent of subgroup analyses.
  
  
  CONCLUSIONS
  Objective electronic monitoring expanded our previous observations of poor adherence in the treatment of acne. There is a considerable potential effect size on adherence for the use of samples, supporting the need for future, well powered studies to assess the value of using samples in the treatment of acne and other dermatologic skin diseases.
authors: Laura F
authors: LF
authors: Sandoval
authors: Ashley
authors: A
authors: Semble
authors: Cheryl J
authors: CJ
authors: Gustafson
authors: Karen E
authors: KE
authors: Huang
authors: Michelle M
authors: MM
authors: Levender
authors: Steven R
authors: SR
authors: Feldman
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy* / Q000473:pathology; D000068816:Adapalene; D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000627:therapeutic use*; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D055118:Medication Adherence; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D010865:Pilot Projects; D012720:Severity of Illness Index; D016037:Single-Blind Method; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D005782:Gels; D009281:Naphthalenes; D000068816:Adapalene; D001585:Benzoyl Peroxide