title: Is there any association of anxiety-depressive symptoms with vascular endothelial function or systemic inflammation?
abstract: BACKGROUND
  Studies have shown the association of mood disorders and endothelial dysfunction, and increased risk of cardiovascular disease; however, mediatory mechanisms are not entirely clarified in this regard. We investigated the relationship between depression/anxiety symptoms with systemic inflammation and endothelial function.
  
  
  METHODS
  This cross-sectional study was performed in 2011 on employees of an oil company located in the Isfahan city (central Iran). Participants were selected with clustered random sampling. Anxiety and depression were evaluated by Hospital Anxiety Depression Scale (HADS). Systemic inflammatory status was evaluated by measuring sensitive C-reactive protein (high sensitive-CRP). To evaluate the endothelial function flow-mediated dilation (FMD) was measured.
  
  
  RESULTS
  During the study period, 254 participants (mean age = 51.4 ± 6.1 years) were evaluated. No significant relationship was found between high sensitive-CRP or FMD and any of the variables of anxiety or depression. In multivariate analysis, by controlling the possible confounding factors, no association was found between anxiety score, depression, or the overall score of HADS with high sensitive-CRP or FMD. After the separate analysis of patients with and without diabetes, depression score was correlated inversely with FMD among patients with diabetes (r = 0.525, P = 0.021).
  
  
  CONCLUSIONS
  According to the results, in the studied population, there was no relationship between anxiety/depression with systemic inflammation or endothelial dysfunction, while in individuals with diabetes, depression was associated with endothelial dysfunction. In this regard more cohort studies are recommended.
authors: Department of Psychiatry, Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Gholam Reza
authors: GR
authors: Kheirabadi
authors: Department of Psychiatry, Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Fateme
authors: F
authors: Toghani
authors: Department of Psychiatry, Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Marjan
authors: M
authors: Kousha
authors: Department of cardiologist, Cardiovascular Disease Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mohammad
authors: M
authors: Hashemi
authors: Department of Psychiatry, Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mohammad Reza
authors: MR
authors: Maracy
authors: Department of Biology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Mohammad Reza
authors: MR
authors: Sharifi
authors: Department of Psychiatry, Behavioral Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Reza
authors: R
authors: Bagherian-Sararoudi
keywords: Anxiety; cardiovascular diseases; depression; inflammation; vascular endothelial