title: Genome sequence and comparative analysis of a Vibrio cholerae O139 strain E306 isolated from a cholera case in China.
abstract: BACKGROUND
  Vibrio cholerae is a human intestinal pathogen and V. cholerae of the O139 serogroups are responsible for the current epidemic cholera in China. In this work, we reported the whole genome sequencing of a V. cholerae O139 strain E306 isolated from a cholera patient in the 306th Hospital of PLA, Beijing, China.
  
  
  RESULTS
  We obtained the draft genome of V. cholerae O139 strain E306 with a length of 4,161,908 bps and mean G + C content of 47.7%. Phylogenetic analysis indicated that strain E306 was very close to another O139 strain, V. cholerae MO10, which was isolated during the cholera outbreak in India and Bangladesh. However, unlike MO10, strain E306 harbors the El Tor-specific RS1 element with no pre-CTX prophage (VSK), very similar to those found in some V. cholerae O1 strains. In addition, strain E306 contains a SXT/R391 family integrative conjugative element (ICE) similar to ICEVchInd4 and SXT MO10, and it carries more antibiotic resistance genes than other closest neighbors.
  
  
  CONCLUSIONS
  The genome sequence of the V. cholerae O139 strain E306 and its comparative analysis with other V. cholerae strains we present here will provide important information for a better understanding of the pathogenicity of V. cholerae and their molecular mechanisms to adapt different environments.
authors: The 306th Hospital of PLA, Beijing 100101, China.
authors: Yong
authors: Y
authors: Yi
authors: CAS key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.|Beijing Key Laboratory of Microbial Drug Resistance and Resistome, Beijing 100101, China.
authors: Na
authors: N
authors: Lu
authors: CAS key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.|Beijing Key Laboratory of Microbial Drug Resistance and Resistome, Beijing 100101, China.
authors: Fei
authors: F
authors: Liu
authors: CAS key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.|Beijing Key Laboratory of Microbial Drug Resistance and Resistome, Beijing 100101, China.
authors: Jing
authors: J
authors: Li
authors: CAS key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.|Beijing Key Laboratory of Microbial Drug Resistance and Resistome, Beijing 100101, China.
authors: Ruifen
authors: R
authors: Zhang
authors: The 306th Hospital of PLA, Beijing 100101, China.
authors: Liping
authors: L
authors: Jia
authors: The 306th Hospital of PLA, Beijing 100101, China.
authors: Hua
authors: H
authors: Jing
authors: The 306th Hospital of PLA, Beijing 100101, China.
authors: Hu
authors: H
authors: Xia
authors: Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors: Yi
authors: Y
authors: Yang
authors: CAS key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.|Beijing Key Laboratory of Microbial Drug Resistance and Resistome, Beijing 100101, China.
authors: Baoli
authors: B
authors: Zhu
authors: CAS key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.|Beijing Key Laboratory of Microbial Drug Resistance and Resistome, Beijing 100101, China.
authors: Yongfei
authors: Y
authors: Hu
authors: The 306th Hospital of PLA, Beijing 100101, China.
authors: Yan
authors: Y
authors: Cui