title: Fatty acid metabolism: Implications for diet, genetic variation, and disease.
abstract: Cultures across the globe, especially Western societies, are burdened by chronic diseases such as obesity, metabolic syndrome, cardiovascular disease, and cancer. Several factors, including diet, genetics, and sedentary lifestyle, are suspected culprits to the development and progression of these health maladies. Fatty acids are primary constituents of cellular physiology. Humans can acquire fatty acids byde novosynthesis from carbohydrate or protein sources or by dietary consumption. Importantly, regulation of their metabolism is critical to sustain balanced homeostasis, and perturbations of such can lead to the development of disease. Here, we reviewde novoand dietary fatty acid metabolism and highlight recent advances in our understanding of the relationship between dietary influences and genetic variation in fatty acid metabolism and their role in chronic diseases.
authors: Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors: Janel
authors: J
authors: Suburu
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P.R. China ; Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors: Zhennan
authors: Z
authors: Gu
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P.R. China.
authors: Haiqin
authors: H
authors: Chen
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P.R. China.
authors: Wei
authors: W
authors: Chen
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P.R. China.
authors: Hao
authors: H
authors: Zhang
authors: State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P.R. China ; Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
authors: Yong Q
authors: YQ
authors: Chen
keywords: De novo lipogenesis; Dietary fatty acids; Fatty acid metabolism; Genetic variation