title: Approaching frailty as the new geriatric syndrome.
abstract: Ageing is inevitably associated with a decline in physiologic reserves. Frailty results from reaching a threshold of decline across multiple organ systems. By consequence, it is associated with a high vulnerability and reduced ability to maintain homeostasis. This vulnerability is not only age-related, but also related to disability and comorbidity, as illustrated by three clinical cases. Sarcopenia, which is defined as age-related loss of muscle mass, is considered to be a central manifestation of frailty. In addition to being highly prevalent in elderly population, frailty also exerts a substantial impact on quality of life. As it is extremely challenging by defying conventional medication and involving new therapeutically approaches, frailty fully qualifies as a new geriatric syndrome.
authors: Discipline of Internal Medicine, Nephrology and Geriatrics, "Dr. C.I. Parhon" Hospital Iaşi.
authors: Ioana Dana
authors: ID
authors: Alexa
authors: Discipline of Internal Medicine, Nephrology and Geriatrics, "Dr. C.I. Parhon" Hospital Iaşi.
authors: Adina Carmen
authors: AC
authors: Ilie
authors: Discipline of Internal Medicine, Nephrology and Geriatrics, "Dr. C.I. Parhon" Hospital Iaşi.
authors: Anca
authors: A
authors: Moroşanu
authors: Department of Clinical Geriatrics, University of Medicine and Pharmacy "Grigore T. Popa", Iaşi.
authors: Ana
authors: A
authors: Voica
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D006233:Persons with Disabilities; D017809:Fatal Outcome; D005221:Fatigue; D005260:Female; D016330:Frail Elderly; D005853:Geriatrics; D006706:Homeostasis; D006801:Humans; D011788:Quality of Life; D012307:Risk Factors; D055948:Sarcopenia; D013577:Syndrome