title: Spectroscopic characterization of Lanthanoid derived from a hexadentate macrocyclic ligand: study on antifungal capacity of complexes.
abstract: Complexes of Ce(III), Nd(III), Sm(III) and Eu(III) were synthesized with NO-donor macrocyclic ligand, i.e. 3,5,13,15,21,22-hexaaza-2,6,12,16-tetramethyl-4,14-dithia-tricyclo[15.3.1.1(7-11)]docosane-1(21),2,5,7,9,11(22),12,15,17,19-decaene. The ligand was obtained by the condensation of 2,6-diacetylpyridine with thiourea and characterized by elemental analysis, mass, IR and (1)H NMR spectral studies. All the complexes were characterized by elemental analyses, molar conductance measurements, magnetic susceptibility measurements, IR, mass, electronic spectral techniques and thermal studies. The ligand acts as a hexadentate and coordinated through four nitrogen atoms of azomethine groups and two nitrogen atoms of pyridine ring. The value of spectral parameters i.e. nephelauxetic effect (b), covalency factor (b(1/2)), Sinha parameter (δ%) and covalency angular overlap parameter (η) account for the covalent nature of the complexes. The macrocyclic ligand and its Lanthanoid were tested in vitro against two plant pathogenic fungi in order to assess their antifungal capacity.
authors: Department of Chemistry, Zakir Husain Delhi College (University of Delhi), JLN-Marg, New Delhi 110 002, India. Electronic address: schandra_00@yahoo.com.
authors: Sulekh
authors: S
authors: Chandra
authors: Department of Chemistry, Motilal Nehru College (University of Delhi), Benito Juarez Road, New Delhi 110 021, India.
authors: Swati
authors: S
authors: Agrawal
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004583:Electrons; D005658:Fungi / Q000187:drug effects / Q000254:growth & development; D028581:Lanthanoid Series Elements / Q000494:pharmacology*; D008024:Ligands; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D066244:Proton Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013696:Temperature
chemical_list: D000935:Antifungal Agents; D028581:Lanthanoid Series Elements; D008024:Ligands; D047028:Macrocyclic Compounds
keywords: Antifungal capacity; Hexadentate ligand; Lanthanoid; Spectroscopic characterization