title: High-intensity swimming exercise increases dust mite extract and 1-chloro-2,4-dinitrobenzene-derived atopic dermatitis in BALB/c mice.
abstract: The aim of this study was to investigate the effect of high-intensity swimming exercise (HISE) on atopic dermatitis (AD). For the study, we established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 1-chloro-2,4-dinitrobenzene (CDNB) to the ears. After HISE for 4 weeks, epidermal thickness, mast cell infiltration, serum immunoglobulin E (IgE), and histamine were measured. In addition, the gene expression of interleukin (IL)-5 and IL-31 in the ears was assayed. HISE increased DFE/CDNB-induced AD symptoms based on ear thickness, histopathological analysis, and serum IgE level. Moreover, HISE exercise stimulated mast cell infiltration into the ear, elevation of serum histamine, and DFE/CDNB-induced expression of IL-5 and IL-31 in the ears in the AD model. Taken together, our results indicate the possibility that HISE-induced stress gives rise to AD symptoms through the stimulation of IgE level by increasing IL-5 and IL-31 production.
authors: Laboratory of Immunotoxicology, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 700-422, Republic of Korea.
authors: Sang-Hyun
authors: SH
authors: Kim
authors: Eun-Kyung
authors: EK
authors: Kim
authors: Eun-Ju
authors: EJ
authors: Choi
mesh_terms: D000818:Animals; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology; D004137:Dinitrochlorobenzene / Q000737:chemistry*; D004195:Disease Models, Animal; D004817:Epidermis / Q000276:immunology; D005260:Female; D006632:Histamine / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D015848:Interleukin-5 / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D008407:Mast Cells / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C; D008925:Mites / Q000737:chemistry*; D010805:Physical Conditioning, Animal; D013550:Swimming
chemical_list: D004137:Dinitrochlorobenzene; D015848:Interleukin-5; D007378:Interleukins; C502588:interleukin-31, mouse; D007073:Immunoglobulin E; D006632:Histamine