title: Intracranial volume inversely correlates with serum 25(OH)D level in healthy young women.
abstract: OBJECTIVE
  Vitamin D is important in normal brain development. In animals low vitamin D level is associated with brain morphological alterations including enlargement of the brain. Whether a similar association exists in humans is unknown. Here we investigated the relationship between vitamin D and total intracranial volume as well as total volume of the cortical grey and cerebral white matter and that of the ventricles in young healthy women.
  
  
  METHODS
  To assess volumes we applied semi-automatic user-independent MR volumetry. For the vitamin D measurements automated electrochemiluminescence immunoassay was used.
  
  
  RESULTS
  We found a significant negative correlation between vitamin D and total intracranial volume as well as total cortical grey and cerebral white matter volumes.
  
  
  CONCLUSIONS
  This association may reflect a trait-like relationship between vitamin D and brain size possibly determined in early development.
authors: Enikő
authors: E
authors: Plózer
authors: Anna
authors: A
authors: Altbäcker
authors: Gergely
authors: G
authors: Darnai
authors: Gábor
authors: G
authors: Perlaki
authors: Gergely
authors: G
authors: Orsi
authors: Szilvia Anett
authors: SA
authors: Nagy
authors: Attila
authors: A
authors: Schwarcz
authors: Tamás
authors: T
authors: Kőszegi
authors: Gábor László
authors: GL
authors: Woth
authors: Tivadar
authors: T
authors: Lucza
authors: Norbert
authors: N
authors: Kovács
authors: Sámuel
authors: S
authors: Komoly
authors: Zsófia
authors: Z
authors: Clemens
authors: József
authors: J
authors: Janszky
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000473:pathology*; D055815:Young Adult
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: 25(OH)D; Brain volumetry; Intracranial volume; MRI; Vitamin D