title: PTPLAD2 is a tumor suppressor in esophageal squamous cell carcinogenesis.
abstract: Esophageal squamous cell carcinomas (ESCCs) are highly invasive and have poor prognoses. We investigated the role of PTPLAD2, a protein tyrosine phosphatase-like A domain (PTPLAD) family member, in ESCC carcinogenesis. Survival analysis was performed using patient data. ESCC tissue samples lost PTPLAD2 heterozygosity and had decreased PTPLAD2 expression. Low PTPLAD2 expression and high p-STAT3 correlated with poor prognosis. Overexpression of PTPLAD2 in ESCC cells reduced STAT3 phosphorylation, decreased FoxM1, inhibited proliferation and decreased in mouse xenograft tumor formation. Therefore, PTPLAD2 is a potential tumor suppressor and prognostic indicator that reduces STAT3 phosphorylation. PTPLAD2 is a possible clinical target for ESCC treatment.
authors: The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: zhusjly@fmmu.edu.cn.
authors: Shaojun
authors: S
authors: Zhu
authors: Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China. Electronic address: zhipengw@fmmu.edu.cn.
authors: Zhipeng
authors: Z
authors: Wang
authors: Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: zhangzhipei2013@hotmail.com.
authors: Zhipei
authors: Z
authors: Zhang
authors: Department of Thoracic Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: wjtm1976@163.com.
authors: Jian
authors: J
authors: Wang
authors: The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China; Department of Gynecology and Obstetrics, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: lyhzhw@fmmu.edu.cn.
authors: Yanhong
authors: Y
authors: Li
authors: The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: yaoli@fmmu.edu.cn.
authors: Li
authors: L
authors: Yao
authors: Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi'an, China. Electronic address: qbmei@fmmu.edu.cn.
authors: Qibing
authors: Q
authors: Mei
authors: The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China. Electronic address: zhwlyh@fmmu.edu.cn.
authors: Wei
authors: W
authors: Zhang
mesh_terms: D000818:Animals; D063646:Carcinogenesis / Q000378:metabolism* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D006836:Hydro-Lyases; D053208:Kaplan-Meier Estimate; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008875:Middle Aged; D041681:NIH 3T3 Cells; D009368:Neoplasm Transplantation; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D050796:STAT3 Transcription Factor / Q000378:metabolism; D047368:Tumor Burden; D025521:Tumor Suppressor Proteins / Q000502:physiology*
chemical_list: C107585:FOXM1 protein, human; D000072278:Forkhead Box Protein M1; D051858:Forkhead Transcription Factors; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D025521:Tumor Suppressor Proteins; D006836:Hydro-Lyases; C588244:HACD4 protein, human
keywords: Esophageal cancer; PTPLAD2; Prognosis; Proliferation; Signal transducer and activator of transcription 3