title: Recommendations from the Spanish Oncology Genitourinary Group for the treatment of patients with renal cell carcinoma.
abstract: Clear-cell renal cell carcinoma (RCC) is the most common kidney cancer. New treatment options of localized RCC recently incorporated include laparoscopic surgery, nephron-sparing surgery, ablative techniques and active surveillance. But 50 % of patients may develop disease recurrence attributable to subclinical metastases. In these cases, and considering the low benefits of chemotherapy, new targeted therapies such as tyrosine kinase inhibitors (TKIs) and mammalian target of rapamycin (mTOR) inhibitors have been developed as first- and second-line treatment. Both sunitinib and pazopanib are TKIs that constitute the first-line treatment option in patients with metastatic RCC. As second-line treatment, sequential therapy with a second TKI or a mTOR inhibitor is recommended. This review has collected together a series of recommendations issued by the Spanish Oncology Genitourinary Group with the aim of facilitating the treatment of these patients. Each recommendation is accompanied by the level of evidence and grade of recommendation on the basis of the available data.
authors: Genitourinary and Sarcoma Unit, Department of Medical Oncology, Institut Català d'Oncologia L'Hospitalet, Gran Via de L'Hospitalet, 199-203, 08908, L'Hospitalet, Barcelona, Spain, garciadelmuro@iconcologia.net.
authors: Xavier
authors: X
authors: García Del Muro
authors: Enrique
authors: E
authors: Gallardo
authors: Iciar
authors: I
authors: García Carbonero
authors: Nuria
authors: N
authors: Laínez
authors: María
authors: M
authors: José Méndez
authors: Pablo
authors: P
authors: Maroto
authors: María
authors: M
authors: Ochoa de Olza
authors: Javier
authors: J
authors: Puente
authors: Gaspar
authors: G
authors: Reynes
authors: José
authors: J
authors: Rubio
authors: Carmen
authors: C
authors: Santander
authors: Cristina
authors: C
authors: Suárez
authors: Sergio
authors: S
authors: Vázquez Estévez
authors: Daniel
authors: D
authors: Castellano
mesh_terms: D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors
chemical_list: D020794:Receptor Protein-Tyrosine Kinases