title: Immunomodulatory effect of ethanolic extract of Shirishadi compound.
abstract: Immunomodulators are substances that helps to regulate the immune system. The basic mechanisms by which the herbs defend the body against infection have two probable ways- one by destroying pathogens and other by enhancing the body immunity. Shirishadi compound is a polyherbal drug used in Ayurvedic system of medicine for the management of allergic disorders such as allergic rhinitis, allergic asthma etc., The present study was carried out to evaluate the immunomodulatory activity of ethanolic extract of polyherbal compound "Shirishadi" on Swiss albino mice. Cyclophosphamide (CP) induced immunosuppression model was used to assess the activity of drug. CP was given in the dose of 30 mg/kg body weight through i.p route. 500 mg/kg body weight of Shirishadi polyherbal drug was given through oral route. The extent of protection against immunosuppression caused by CP was evaluated after 14 days of drug administration, by estimating hematological parameters and neutrophil adhesion test. Ethanolic extracts of Shirishadi compound showed pronounced immunoprotective activity by increasing the depleted levels of total WBC count and RBC, % Hb, and % neutrophils adhesion. The extract was found to be an effective immunomodulatory agent.
authors: Assistant Professor, Department of Kayachikitsa, C.B.P.A.C.S, New Delhi, India.
authors: Divya
authors: D
authors: Kajaria
authors: Associate Professor, Department of Kayachikitsa, IMS, BHU, Varanasi, Uttar Pradesh, India.
authors: Jyoti Shankar
authors: JS
authors: Tripathi
authors: Ex. Professor and Head, Department of Kayachikitsa, IMS, BHU, Varanasi, Uttar Pradesh, India.
authors: Shri Kant
authors: SK
authors: Tiwari
authors: Professor and Head, Department of Pharmacology, IMS, BHU, Varanasi, Uttar Pradesh, India.
authors: Bajrangi Lal
authors: BL
authors: Pandey
keywords: Shirishadi compound; cyclophosphamide; immunomodulatory activity