title: One-pot multicomponent synthesis of highly functionalized piperidines from substituted β-nitrostyrenes, Meldrum's acid, aromatic aldehydes, and ammonium acetate.
abstract: An efficient and straightforward synthetic protocol has been developed for the diversity-oriented synthesis of highly functionalized piperidines containing a Meldrum's acid moiety via pseudo five-component reaction between aromatic aldehydes, ammonium acetate, substituted β-nitrostyrenes and Meldrum's acid for the generation of a wide range of structurally interesting and pharmacologically significant compounds.
authors: School of Chemistry and Chemical Engineering, Yangzhou University , 180 Siwangting Street, Yangzhou 225002, P. R. China.
authors: Yan
authors: Y
authors: Li
authors: Zhiheng
authors: Z
authors: Xue
authors: Weijian
authors: W
authors: Ye
authors: Juanjuan
authors: J
authors: Liu
authors: Juan
authors: J
authors: Yao
authors: Cunde
authors: C
authors: Wang
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D004146:Dioxanes / Q000737:chemistry*; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D013343:Styrenes / Q000737:chemistry*
chemical_list: D000085:Acetates; D000447:Aldehydes; D004146:Dioxanes; D010880:Piperidines; D013343:Styrenes; C011955:beta-nitrostyrene; C076489:Meldrum's acid; C018824:ammonium acetate