title: Comparing risk of new onset diabetes mellitus in chronic kidney disease patients receiving peritoneal dialysis and hemodialysis using propensity score matching.
abstract: Chronic kidney disease (CKD) patients are at risk for developing new-onset diabetes mellitus (NODM) even after hemodialysis (HD) and peritoneal dialysis (PD) treatment. It is not clear if the incidence for NODM is different in CKD patients receiving HD and PD. This study compared the risk of NODM in PD patients and HD patients.
  
  
  METHODS
  All HD and PD patients in Taiwan Renal Registry Database from 1997 to 2005 were included and all patients were followed to December 31, 2008. The risk of NODM was analyzed in PD patients and propensity score matched HD patients using logistic regression for early type NODM (< = 6 months after dialysis) and Cox regression for late type NODM (>6 months after dialysis).
  
  
  RESULTS
  A total of 2548 PD patients and 10192 HD patients who had no diabetes on the initiation of dialysis were analyzed. The incidence for NODM was 3.7 per 100 patient/year for HD and 2.4 for PD patients. HD patients are more at risk for developing early type NODM (p<0.001) with an adjusted odds ratio of 1.41 [95% confidence interval (CI) 1.12-1.78)]. HD patients are more at risk for late type NODM (p<0.001) with an adjusted hazard ratio of 2.01 (95% CI: 1.77-2.29). Patient's age was negatively associated with risk of early type of NODM (p<0.001) but positively associated with risk of late type NODM (p<0.001).
  
  
  CONCLUSIONS
  Chronic kidney disease patients receiving hemodialysis are more at risk for developing new-onset diabetes mellitus compared to those receiving peritoneal dialysis.
authors: Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan ; Department of Medicine, China Medical University, Taichung, Taiwan.
authors: Che-Yi
authors: CY
authors: Chou
authors: Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.
authors: Chih-Chia
authors: CC
authors: Liang
authors: Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan ; Department of Medicine, China Medical University, Taichung, Taiwan.
authors: Huey-Liang
authors: HL
authors: Kuo
authors: Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan ; Department of Medicine, China Medical University, Taichung, Taiwan.
authors: Chiz-Tzung
authors: CT
authors: Chang
authors: Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan ; Department of Medicine, China Medical University, Taichung, Taiwan.
authors: Jiung-Hsiun
authors: JH
authors: Liu
authors: Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan ; Department of Medicine, China Medical University, Taichung, Taiwan.
authors: Hsin-Hung
authors: HH
authors: Lin
authors: Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan ; Department of Medicine, China Medical University, Taichung, Taiwan.
authors: I-Kuan
authors: IK
authors: Wang
authors: Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan ; Department of Medicine, China Medical University, Taichung, Taiwan.
authors: Ya-Fei
authors: YF
authors: Yang
authors: Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan ; Department of Medicine, China Medical University, Taichung, Taiwan.
authors: Chiu-Ching
authors: CC
authors: Huang
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010530:Peritoneal Dialysis; D057216:Propensity Score; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000401:mortality / Q000628:therapy; D012306:Risk