title: Neurogenesis and maturation in neonatal brain injury.
abstract: The incidence of preterm birth is on the rise. The outcome of premature birth can vary widely, spanning completely normal development to severe neurologic deficits, with most children showing mild to moderate cognitive delay and increased incidence of neuropsychiatric conditions such as anxiety, attention deficit hyperactivity, and autism spectrum disorders. Several animal models have been employed to study the consequences of prematurity, one of the most promising being chronic perinatal hypoxia in mouse, which recapitulates the cognitive impairments, partial recovery over time and enhanced recovery with environmental enrichment.
authors: Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA.
authors: Natalina
authors: N
authors: Salmaso
authors: Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA.
authors: Simone
authors: S
authors: Tomasi
authors: Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA; Department of Neurobiology, Kavli Institute for Neuroscience, Yale University, 333 Cedar Street, New Haven, CT 06520, USA. Electronic address: flora.vaccarino@yale.edu.
authors: Flora M
authors: FM
authors: Vaccarino
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000166:cytology*; D001921:Brain / Q000196:embryology / Q000254:growth & development*; D001930:Brain Injuries / Q000503:physiopathology*; D002658:Developmental Disabilities / Q000503:physiopathology*; D004195:Disease Models, Animal; D005865:Gestational Age; D006801:Humans; D002534:Hypoxia, Brain / Q000503:physiopathology*; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D055495:Neurogenesis / Q000502:physiology*
keywords: Cognitive delay; Neonatal brain injury; Neurogenesis; Preterm birth