title: Prevalence and risk factors for depression in newly diagnosed patients with POEMS syndrome.
abstract: This prospective study delineated the prevalence and risk factors for clinical depression in patients with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes). Using a PHQ-9 (Patient Health Questionnaire scale-9, which evaluates the severity of depressive symptoms) score cut-off ≥ 10, the prevalence of pretreatment depression was 38.0%. Based on multivariate logistic regression, higher ONLS (Overall Neuropathy Limitation Scale, which assesses the severity of neuropathy) upper limb scores (hazard ratio [HR] 1.75; 95% confidence interval [CI] 1.09-2.81; p = 0.02) and ascites (HR 4.30; 95% CI 1.03-17.9; p = 0.04) were significant and independent predictors for depression. The incidence of post-treatment depression was 1.53% by the end of follow-up, while no patients received antidepressants. A preliminary logistic regression suggested depression to be a risk factor for early death (within 3 months after diagnosis) (HR 9.77; 95% CI, 1.08-88.9; p = 0.04).
authors: Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China.
authors: Lu
authors: L
authors: Zhang
authors: Yin-Lei
authors: YL
authors: Zhou
authors: Wei
authors: W
authors: Zhang
authors: Ming-Hui
authors: MH
authors: Duan
authors: Xin-Xin
authors: XX
authors: Cao
authors: Dao-Bin
authors: DB
authors: Zhou
authors: Jian
authors: J
authors: Li
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality; D016878:POEMS Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
keywords: PHQ-9; POEMS syndrome; depression