title: Synthesis and evaluation of antioxidant activity of some new benzylidene-thiazolidine-xanthine derivatives.
abstract: The International Diabetes Federation reported that 246 million adults worldwide had diabetes mellitus and the prevalence of this syndrome was expected to increase continuously.
  
  
  OBJECTIVE
  To design new compound with potential antidiabetic and antioxidant activity.
  
  
  METHODS
  New benzylidene-thiazolidine derivatives (BT2a-2e) were obtained by condensation of xanthine-thiazolidine-4-one (TZ-4-one) with aromatic aldehydes. The synthesized compounds were characterized by spectral method (IR, 1H-NMR, 13C-NMR) and their antioxidant potential has been also evaluated.
  
  
  RESULTS
  The synthesized compounds have important antioxidant effects as compared to xanthine-thiazolidine derivatives. The most active compounds were those obtained by condensation with 4-dimethylaminobenzaldehyde (BT2c) and 4-nitro-benzaldehyde (BT2e).
  
  
  CONCLUSIONS
  The chemical modulations performed on the structure of TZD-4-one have a good influence on their antioxidant potential.
authors: Faculty of Pharmacy, University of Medicine and Pharmacy Grigore. T. Popa, Iaşi.
authors: Florentina
authors: F
authors: Lupaşcu
authors: Faculty of Pharmacy, University of Medicine and Pharmacy Grigore. T. Popa, Iaşi.
authors: Oana Maria
authors: OM
authors: Dragostin
authors: Faculty of Pharmacy, University of Medicine and Pharmacy Grigore. T. Popa, Iaşi.
authors: Maria
authors: M
authors: Apotrosoaei
authors: Faculty of Pharmacy, University of Medicine and Pharmacy Grigore. T. Popa, Iaşi.
authors: Andreea
authors: A
authors: Pânzariu
authors: Discipline of Pharmaceutical Chemistry, Romanian Acadamy, Faculty of Pharmacy, University of Medicine and Pharmacy Grigore. T. Popa, Iaşi.
authors: Lupaşcu
authors: L
authors: Dan
authors: Petru Poni Institute of Macromolecular Chemistry, Iaşi.
authors: Cornelia
authors: C
authors: Vasile
authors: Discipline of Pharmaceutical Chemistry, Romanian Acadamy, Faculty of Pharmacy, University of Medicine and Pharmacy Grigore. T. Popa, Iaşi.
authors: Lenuţa
authors: L
authors: Profire
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013053:Spectrophotometry / Q000379:methods; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019820:Xanthine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000447:Aldehydes; D000975:Antioxidants; D001597:Benzylidene Compounds; D007004:Hypoglycemic Agents; D053778:Thiazolidines; D019820:Xanthine