title: Role of leptin receptor gene polymorphisms in susceptibility to the development of essential hypertension: a case-control association study in a Northern Han Chinese population.
abstract: In order to explore the potential association between the leptin receptor (LEPR) gene polymorphisms and essential hypertension (EH) risk in the Northern Han Chinese population, we recruited 823 hypertensive subjects and 491 healthy control subjects from the Northern Han Chinese. Genotyping was performed to identify the Lys109Arg, Gln223Arg and Lys656Asn polymorphisms of the LEPR gene. Significant associations were found in a dominant genetic model ([GG+AG] vs. AA), P=0.007, odds ratio (OR)=3.697, 95% confidence interval (CI) 1.442-9.482), and in homozygote comparison (GG vs. AA, P=0.005, OR=3.890, 95% CI 1.501-10.077) for the Gln223Arg polymorphism. No significant association could be found between Lys109Arg or Lys656Asn polymorphism and EH risk. Linkage disequilibrium was detected between the Lys109Arg and Gln223Arg polymorphisms, and haplotype analyses identified that the G-A haplotype was a protective haplotype for EH. Our studies demonstrated that the LEPR Gln223Arg polymorphism had an important role in a patient's susceptibility to EH in the Northern Han Chinese population.
authors: Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, PR China.
authors: Y
authors: Y
authors: Liu
authors: 1] Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, PR China [2] Department of Pulmonary Disease, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, PR China.
authors: Y Q
authors: YQ
authors: Lou
authors: Emergency Department, China MeiTan General Hospital, National Mining Medical Center, Beijing, PR China.
authors: K
authors: K
authors: Liu
authors: Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, PR China.
authors: J L
authors: JL
authors: Liu
authors: Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, PR China.
authors: Z G
authors: ZG
authors: Wang
authors: Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, PR China.
authors: J
authors: J
authors: Wen
authors: 1] Department of Medicine, Division of Cardiology, Northwestern University, Chicago, IL, USA [2] Department of Medicine & Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
authors: Q
authors: Q
authors: Zhao
authors: Department of Hypertension Research, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, PR China.
authors: S J
authors: SJ
authors: Wen
authors: Department of Medicine & Center for Cardiovascular Research, University of Illinois at Chicago, Chicago, IL, USA.
authors: L
authors: L
authors: Xiao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D001794:Blood Pressure / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China / Q000453:epidemiology; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D054411:Receptors, Leptin / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C515448:LEPR protein, human; D054411:Receptors, Leptin