title: [Antimicrobial activity of several drugs against extended-spectrum beta-lactamase positive Enterobacteriaceae isolates in Gifu and Aichi prefecture].
abstract: We investigated the antimicrobial activity of several drugs against 131 extended-spectrum beta-lactamase (ESBL) positive clinical isolates in Gifu and Aichi prefecture from 2007 to 2011. Meropenem (MEPM) and doripenem (DRPM) gave the lowest MIC50 at 0.0313 microg/mL. MEPM gave the lowest MIC90 at 0.0625 microg/mL. According to the Clinical and Laboratory Standards Institute breakpoints, the susceptible rates of carbapenems, tazobactam/piperacillin (TAZ/PIPC) and cefmetazole (CMZ) were higher than 90%. The susceptible rates of MEPM, DRPM, imipenem (IPM), TAZ/PIPC and CMZ were 98.5%, 98.5%, 94.7%, 94.7% and 92.4%. We used the PCR method and identified the molecular types of the ESBL positive isolates. Seventy-two strains had CTX-M-9 group gene and CTX-M-9 group gene is the most frequently detected. Against the CTX-M-9 group gene harboring strains which were the most common in our investigation, the susceptible rates of TAZ/PIPC, MEPM, DRPM and IPM were 100%. It is suggested that not only carbapenems but also TAZ/PIPC and CMZ are useful against infections caused by ESBL positive isolates.
authors: Research Laboratories, Toyama Chemical Co., Ltd.
authors: Satoshi
authors: S
authors: Nakagawa
authors: Research Laboratories, Toyama Chemical Co., Ltd.
authors: Harumi
authors: H
authors: Hisada
authors: Research Laboratories, Toyama Chemical Co., Ltd.
authors: Nobuhiko
authors: N
authors: Nomura
authors: Research Laboratories, Toyama Chemical Co., Ltd.
authors: Junichi
authors: J
authors: Mitsuyama
authors: Matsubara Otorhinolaryngology Clinic.
authors: Shigenori
authors: S
authors: Matsubara
authors: Gifu University of Medical Science.
authors: Kazukiyo
authors: K
authors: Yamaoka
authors: Division of Anaerobe Research, Life Science Research Center, Gifu University.
authors: Kunitomo
authors: K
authors: Watanabe
authors: Department of Clinical Laboratory Medicine, Ogaki Municipal Hospital.
authors: Yuko
authors: Y
authors: Asano
authors: Division of Infection Control and Prevention, Aichi Medical University Hospital.
authors: Hiroyuki
authors: H
authors: Suematsu
authors: Division of Infection Control and Prevention, Aichi Medical University Hospital.
authors: Haruki
authors: H
authors: Sawamura
authors: Takayama Red Cross Hospital.
authors: Hikonori
authors: H
authors: Hashido
authors: Department of Clinical Infectious Diseases, Aichi Medical University Graduate School of Medicine.
authors: Yuka
authors: Y
authors: Yamagishi
authors: Department of Clinical Infectious Diseases, Aichi Medical University Graduate School of Medicine.
authors: Hiroshige
authors: H
authors: Mikamo
authors: Clinical Laboratories, Gifu Prefectural Tajimi Hospital.
authors: Yoko
authors: Y
authors: Matsukawa
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000032:analysis*
chemical_list: D000890:Anti-Infective Agents; D001618:beta-Lactamases