title: A new strategy to construct a C=C-CF3 subunit via CuBr-catalyzed domino reaction of homopropargyl amines: an efficient synthesis of trifluoromethyl containing building blocks 4-trifluoromethyl-2,3-dihydro-pyrroliums.
abstract: A new strategy for the construction of a C=C-CF3 subunit has been developed via CuBr-catalyzed domino cyclization-trifluoromethylation of homopropargyl amines with Umemoto's reagent. 4-Trifluoromethyl-2,3-dihydro-pyrroliums were produced in high yields. The usefulness of these products has been demonstrated by the transformation of them into various other trifluoromethylated molecules.
authors: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry (SIOC), Chinese Academy of Sciences (CAS), 345 Lingling Road, Shanghai 200032, China. dingch@sioc.ac.cn xlhou@sioc.ac.cn.
authors: Guang-Cun
authors: GC
authors: Ge
authors: Xiao-Jun
authors: XJ
authors: Huang
authors: Chang-Hua
authors: CH
authors: Ding
authors: Shi-Li
authors: SL
authors: Wan
authors: Li-Xin
authors: LX
authors: Dai
authors: Xue-Long
authors: XL
authors: Hou
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D054879:Halogenation; D008745:Methylation; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D001965:Bromides; D011758:Pyrroles; C408079:cupric bromide; D003300:Copper