title: Impact of coagulation in the development of thromboembolic events in patients with spinal cord injury.
abstract: METHODS
  Although the knowledge described about risk factors and venous thromboembolism (VT) in the general population, the impact of these factors in the development of thromboembolic events in patients with spinal injury (SI) caused by spinal cord injury (SCI) is poorly understood.
  
  
  OBJECTIVE
  Evaluate the impact of risk factors in the development of thromboembolic events in patients with SCI.
  
  
  METHODS
  Brazil, São Paulo.
  
  
  METHODS
  Observational, prospective and cross-study. Eligible patients (n=100) had SI by SCI, >18 years. The degree of motor and sensory lesion was evaluated based on American Spinal Injury Association (ASIA) Impairment Scale (AIS). Blood samples were collected for coagulation exams, hemogram, laboratory and biochemical analyses. Ultrasonography analyzes were performed from deep and superficial venous systems of lower limbs. Quantitative real-time PCR experiments were performed in order to investigate mutations in the prothrombin (G20210A) and Leiden factor V (G1691A) genes.
  
  
  RESULTS
  The main finding of this study was the higher occurrence of deep venous thrombosis (DVT) in patients with Leiden factor V and hyperhomocysteinemia. There was no association between SI for DVT, VT and thrombophilia. Also, there was no relation between lupus anticoagulant and anti-cardiolipin.
  
  
  CONCLUSIONS
  There is an important difference in the incidence of DVT in patients with SI by acute and chronic SCI. Therefore, the conduct of the investigation for thrombophilia should be based on clinical factors, risk factors for DVT and family history of thrombosis.
authors: 1] Department of Pathology, University of São Paulo, São Paulo, Brazil [2] Department of Clinical Pathology, Hospital Israelita Albert Einstein, São Paulo, Brazil.
authors: J C
authors: JC
authors: de Campos Guerra
authors: Clinics Hospital, University of São Paulo, São Paulo, Brazil.
authors: M A
authors: MA
authors: Mourão
authors: 1] Cardiology Division, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil [2] Santo Amaro University, São Paulo, Brazil.
authors: C N
authors: CN
authors: França
authors: Institute of Physical Medicine and Rehabilitation, University of São Paulo, São Paulo, Brazil.
authors: C D P
authors: CD
authors: da Rosa
authors: 1] Department of Pathology, University of São Paulo, São Paulo, Brazil [2] Department of Medicine, Federal University of São Paulo, São Paulo, Brazil.
authors: M N
authors: MN
authors: Burattini
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001938:Brazil; D002908:Chronic Disease; D005165:Factor V / Q000235:genetics; D005260:Female; D006801:Humans; D015994:Incidence; D035002:Lower Extremity / Q000098:blood supply / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D012720:Severity of Illness Index; D013119:Spinal Cord Injuries / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging / Q000235:genetics; D019851:Thrombophilia / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology / Q000235:genetics; D014463:Ultrasonography; D054556:Venous Thromboembolism / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology* / Q000235:genetics; D020246:Venous Thrombosis / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology / Q000235:genetics; D055815:Young Adult
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin