title: Blood conservation in cardiac surgery: guidelines and controversies.
abstract: Bleeding related to cardiac surgery is an important clinical problem. Perioperative anemia and transfusion of allogeneic blood products have both been associated with adverse outcome including mortality and major morbidity. Guidelines exist to help determine when the risks of anemia outweigh the risks of transfusion. Perioperative bleeding may be related to several factors including the use of new antithrombotic drugs. A variety of hemostatic drugs have been studied to reduce bleeding and transfusion, although several questions and concerns about them exist. Patient blood management programs can be valuable for management of patients undergoing cardiac surgery.
authors: Department of Anesthesia, St Michael's Hospital, University of Toronto, Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada; Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Electronic address: mazerd@smh.ca.
authors: C David
authors: CD
authors: Mazer
mesh_terms: D000740:Anemia / Q000209:etiology; D000925:Anticoagulants / Q000627:therapeutic use; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001793:Blood Preservation; D006348:Cardiac Surgical Procedures / Q000379:methods*; D015942:Factor VIIa / Q000737:chemistry; D005340:Fibrinogen / Q000737:chemistry; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006470:Hemorrhage / Q000139:chemically induced; D006487:Hemostasis; D006801:Humans; D059035:Perioperative Period; D011994:Recombinant Proteins / Q000737:chemistry; D012306:Risk; D065227:Transfusion Reaction
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D005340:Fibrinogen; C103587:recombinant FVIIa; D015942:Factor VIIa