title: Lack of IgG antibody seropositivity to Borrelia burgdorferi in patients with Parry-Romberg syndrome and linear morphea en coup de sabre in Mexico.
abstract: BACKGROUND
  Progressive hemifacial atrophy or Parry-Romberg Syndrome (PRS) is a rare, acquired, progressive dysplasia of subcutaneous tissue and bone characterized by unilateral facial involvement. Its etiology is unknown, but theories about its pathogenesis include infectious, degenerative, autoimmune, and traumatic causes among others. The causal relationship of PRS and linear morphea en coup de sabre (LMCS) with Borrelia burgdorferi infection remains controversial. Our goal was to serologically determine anti-B. burgdorferi antibodies in patients diagnosed with PRS and LMCS to establish a possible association as a causative agent.
  
  
  METHODS
  We conducted a serology study with patients belonging to a group of 21 individuals diagnosed with PRS, six with LMCS, and 21 matched controls. Anti-Borrelia IgG antibodies were determined by ELISA. A descriptive statistical analysis and Fischer's exact test were done.
  
  
  RESULTS
  In serological tests, only two cases had borderline values and were further analyzed by Western blot with non-confirmatory results. For both the PRS and LMCS group, the association test was not significant, suggesting a lack of association between PRS or LMCS and the presence of anti-Borrelia antibodies.
  
  
  CONCLUSIONS
  In Mexico there are no previous studies on Borrelia infection and its relationship between PRS or LMCS. Our result showed a lack of association of either clinical entities with anti-Borrelia-antibodies. Former reports of this association may suggest coincidental findings without causal relationship.
authors: Graduate Studies Division, Plastic and Reconstructive Surgery, Universidad Nacional Autónoma de México and General Hospital "Dr. Manuel Gea González", Mexico City, Mexico.
authors: Claudia
authors: C
authors: Gutiérrez-Gómez
authors: Ana L
authors: AL
authors: Godínez-Hana
authors: Marisela
authors: M
authors: García-Hernández
authors: María de Lourdes
authors: Mde L
authors: Suárez-Roa
authors: Sonia
authors: S
authors: Toussaint-Caire
authors: Elisa
authors: E
authors: Vega-Memije
authors: Daniela
authors: D
authors: Gutiérrez-Mendoza
authors: Marcia
authors: M
authors: Pérez-Dosal
authors: Carlos E
authors: CE
authors: Medina-De la Garza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D025065:Borrelia burgdorferi / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D005150:Facial Hemiatrophy / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008193:Lyme Disease / Q000150:complications; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D012594:Scleroderma, Localized / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G