title: Modeling the endocrine control of vitellogenin production in female rainbow trout.
abstract: The rainbow trout endocrine system is sensitive to changes in annual day length, which is likely the principal environmental cue controlling its reproductive cycle. This study focuses on the endocrine regulation of vitellogenin (Vg) protein synthesis, which is the major egg yolk precursor in this fish species. We present a model of Vg production in female rainbow trout which incorporates a biological pathway beginning with sex steroid estradiol-17β levels in the plasma and concluding with Vg secretion by the liver and sequestration in the oocytes. Numerical simulation results based on this model are compared with experimental data for estrogen receptor mRNA, Vg mRNA, and Vg in the plasma from female rainbow trout over a normal annual reproductive cycle. We also analyze the response of the model to parameter changes. The model is subsequently tested against experimental data from female trout under a compressed photoperiod regime. Comparison of numerical and experimental results suggests the possibility of a time-dependent change in oocyte Vg uptake rate. This model is part of a larger effort that is developing a mathematical description of the endocrine control of reproduction in female rainbow trout. We anticipate that these mathematical and computational models will play an important role in future regulatory toxicity assessments and in the prediction of ecological risk.
authors: Department of Pathology, University of Wisconsin Hospital and Clinics, Madison WI 53792, United States. kaitlinsundling@gmail.com.
authors: Kaitlin
authors: K
authors: Sundling
authors: Gheorghe
authors: G
authors: Craciun
authors: Irvin
authors: I
authors: Schultz
authors: Sharon
authors: S
authors: Hook
authors: James
authors: J
authors: Nagler
authors: Tim
authors: T
authors: Cavileer
authors: Joseph
authors: J
authors: Verducci
authors: Yushi
authors: Y
authors: Liu
authors: Jonghan
authors: J
authors: Kim
authors: William
authors: W
authors: Hayton
mesh_terms: D000818:Animals; D019295:Computational Biology; D004958:Estradiol / Q000378:metabolism; D005260:Female; D029941:Fish Proteins / Q000096:biosynthesis* / Q000235:genetics; D008099:Liver / Q000378:metabolism; D055641:Mathematical Concepts; D008954:Models, Biological; D017686:Oncorhynchus mykiss / Q000235:genetics / Q000502:physiology*; D010053:Ovary / Q000378:metabolism; D017440:Photoperiod; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D012098:Reproduction / Q000235:genetics / Q000502:physiology; D012621:Seasons; D014818:Vitellogenesis / Q000235:genetics / Q000502:physiology; D014819:Vitellogenins / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D029941:Fish Proteins; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D014819:Vitellogenins; D004958:Estradiol