title: Platelet-rich plasma (PRP): methodological aspects and clinical applications.
abstract: The clinical use of platelet-rich plasma (PRP) is based on the increase in the concentration of growth factors and in the secretion of proteins which are able to maximize the healing process at the cellular level. Since PRP is an autologous biologic material, it involves a minimum risk of immune reactions and transmission of infectious and contagious diseases, and it has been widely used for the recovery of musculoskeletal lesions. Despite the great potential for applicability, the implementation of the therapeutic employment of PRP as a clinical alternative has become difficult, due to the lack of studies related to the standardization of the techniques and/or insufficient description of the adopted procedures. Therefore, it is required establish standard criteria to be followed for obtaining a PRP of high quality, as well as a larger number of studies which should establish the proper concentration of platelets for the different clinical conditions. In this context, the purpose of this review is to discuss some methodological aspects used for achieving the PRP, as well as to discuss the bioactive properties of PRP, and to point out its therapeutic use in different fields of regenerative medicine.
authors: Department of Biological Sciences, University of the State of São Paulo, UNESP , Assis, São Paulo , Brazil .
authors: Laís Fernanda
authors: LF
authors: Marques
authors: Talita
authors: T
authors: Stessuk
authors: Isabel Cristina Cherici
authors: IC
authors: Camargo
authors: Nemi
authors: N
authors: Sabeh Junior
authors: Lucinéia
authors: L
authors: dos Santos
authors: João Tadeu
authors: JT
authors: Ribeiro-Paes
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000494:pharmacology / Q000627:therapeutic use; D016913:Blood Component Transfusion / Q000379:methods; D001847:Bone Diseases / Q000628:therapy; D004195:Disease Models, Animal; D006801:Humans; D009135:Muscular Diseases / Q000628:therapy; D053657:Platelet-Rich Plasma; D052256:Tendinopathy / Q000628:therapy
chemical_list: D001685:Biological Factors
keywords: Bone; cartilage; muscle; platelet-rich plasma; tendon