title: Synthesis of oxidized glycerol monooleate-chitosan polymer and its hydrogel formation for sustained release of trimetazidine hydrochloride.
abstract: In this paper, a lipid material glycerol monooleate was used as the starting material to synthesize the oxidized glycerol monooleate (OGMO). OGMO was subsequently linked to chitosan (CS) via imine bonds (-C=N-) to obtain a new chitosan-based polymer (OGMO-CS), which can form hydrogels rapidly in aqueous media. Scanning electron microscopy, swelling behavior studies and degradation kinetics studies were performed to demonstrate the effect of this synthetic modification on the hydrogels formation of chitosan network and in vitro drug release. The effects of OGMO-CS type, dry hydrogels percentage, release media and drug loading on the sustained release of the model drug trimetazidine hydrochloride were evaluated. The release profiles of the hydrogels could be described by the Peppas-Sahlin mechanism, a combination of Fickian diffusion and Case-II relaxation. Based on the fact that numerous pharmaceutical lipids are available, the present study may pave the way for other lipids to be employed as modifiers of chitosan for more innovative chitosan derivatives with versatile properties and pharmaceutical applications.
authors: School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
authors: Jianjun
authors: J
authors: Zhang
authors: School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, PR China.
authors: Meng
authors: M
authors: Fu
authors: School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
authors: Minyan
authors: M
authors: Zhang
authors: School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.
authors: Liang
authors: L
authors: Xu
authors: School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: amicute@163.com.
authors: Yuan
authors: Y
authors: Gao
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity; D018360:Crystallography, X-Ray; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D056945:Hep G2 Cells; D006801:Humans; D020100:Hydrogels; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D011108:Polymers / Q000138:chemical synthesis* / Q000633:toxicity; D033362:Powder Diffraction; D066244:Proton Magnetic Resonance Spectroscopy; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods; D014292:Trimetazidine / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; D048271:Chitosan; D014292:Trimetazidine
keywords: Chitosan; Glycerol monooleate; Hydrogels; Lipid; Sustained release