title: [Primary cancellous bone formation around micro-chambered beads].
abstract: OBJECTIVE
  The question has been raised whether benign bone defects in patients can be treated with bone forming osteoconductive ceramics achieving primarily a cancellous bone scaffold, which is under load from the beginning.
  
  
  METHODS
  Ten reconstructions were performed in 9patients (6women and 3male), with a mean age of 49 (25-65)years, suffering a high variety of epi- and metaphyseal defects, four tibial fractures, two calcaneal fractures, one pathological phalangeal fracture, one chondroma of the distal femur and two open-wedge osteotomies were filled with micro-chambered ceramic beads of 4 and 6mm in diameter. The mean follow up was 22 (7- 8)months. X-rays and CT-scans formed the basis for the evaluation of the reconstruction of the cancellous bone scaffolds.
  
  
  RESULTS
  All cancellous structures were rebuilt, if completely filled with bone-forming elements. If the filling was incomplete, no physiological cancellous bone scaffold resulted. The β-TCP micro-chambered beads were completely reabsorbed or sandwich-like incorporated at the time of evaluation. The HA micro-chambered beads revealed a contrast enhancement and were integrated in the osseous construction of the bone scaffold.
  
  
  CONCLUSIONS
  Primary cancellous bone formation can be achieved with osteoconductive ceramic micro-chambered beads and can be combined with any osteosynthesis for stable fixation.
authors: Center of Orthopaedic Sciences, Munich, Alemania; Clinic for Restorative Dentistry and Periodontology, Ludwig Maximilian University, Munich, Alemania. Electronic address: mdraener@dent.med.uni-muenchen.de.
authors: M E
authors: ME
authors: Draenert
authors: Center of Orthopaedic Sciences, Munich, Alemania.
authors: Y
authors: Y
authors: Draenert
authors: Center of Orthopaedic Sciences, Munich, Alemania.
authors: K
authors: K
authors: Draenert
authors: Department of Trauma-, Hand-, and Reconstructive Surgery, Saarland University, Homburg, Alemania.
authors: T
authors: T
authors: Pohlemann
authors: Departamento de Traumatología, Clínica Berka, Universidad de Madrid, Madrid, España.
authors: M
authors: M
authors: Erler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001861:Bone Regeneration; D002516:Ceramics; D004867:Equipment Design; D005260:Female; D050723:Fractures, Bone / Q000628:therapy*; D006801:Humans; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D010012:Osteogenesis
keywords: Bone defect; Bone substitute; Cancellous bone; Defecto óseo; Fractura; Fracture; Hueso esponjoso; Open wedge osteotomy; Osteotomía de apertura; Sustitutivo óseo