title: Quantitation of a spin polarization-induced nuclear Overhauser effect (SPINOE) between a hyperpolarized (13) C-labeled cell metabolite and water protons.
abstract: The spin polarization-induced nuclear Overhauser effect (SPINOE) describes the enhancement of spin polarization of solvent nuclei by the hyperpolarized spins of a solute. In this communication we demonstrate that SPINOEs can be observed between [1,4-(13) C2 ]fumarate, hyperpolarized using the dissolution dynamic nuclear polarization technique, and solvent water protons. We derive a theoretical expression for the expected enhancement and demonstrate that this fits well with experimental measurements. Although the magnitude of the effect is relatively small (around 2% measured here), the SPINOE increases at lower field strengths, so that at clinically relevant magnetic fields (1.5-3 T) it may be possible to track the passage through the circulation of a bolus containing a hyperpolarized (13) C-labeled substrate through the increase in solvent water (1) H signal.
authors: Department of Biochemistry, University of Cambridge and Cancer Research UK, Cambridge Research Institute, Cambridge, UK.
authors: Irene
authors: I
authors: Marco-Rius
authors: Sarah E
authors: SE
authors: Bohndiek
authors: Mikko I
authors: MI
authors: Kettunen
authors: Timothy J
authors: TJ
authors: Larkin
authors: Meer
authors: M
authors: Basharat
authors: Colm
authors: C
authors: Seeley
authors: Kevin M
authors: KM
authors: Brindle
mesh_terms: D002250:Carbon Radioisotopes / Q000737:chemistry*; D005650:Fumarates / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D011522:Protons; D012996:Solutions / Q000737:chemistry; D013113:Spin Labels; D014867:Water / Q000737:chemistry*
chemical_list: D002250:Carbon Radioisotopes; D005650:Fumarates; D011522:Protons; D012996:Solutions; D013113:Spin Labels; D014867:Water
keywords: SPINOE; cross-relaxation; signal enhancement; spin-lattice relaxation