title: Bridging the gap between marker-assisted and genomic selection of heading time and plant height in hybrid wheat.
abstract: Based on data from field trials with a large collection of 135 elite winter wheat inbred lines and 1604 F1 hybrids derived from them, we compared the accuracy of prediction of marker-assisted selection and current genomic selection approaches for the model traits heading time and plant height in a cross-validation approach. For heading time, the high accuracy seen with marker-assisted selection severely dropped with genomic selection approaches RR-BLUP (ridge regression best linear unbiased prediction) and BayesCπ, whereas for plant height, accuracy was low with marker-assisted selection as well as RR-BLUP and BayesCπ. Differences in the linkage disequilibrium structure of the functional and single-nucleotide polymorphism markers relevant for the two traits were identified in a simulation study as a likely explanation for the different trends in accuracies of prediction. A new genomic selection approach, weighted best linear unbiased prediction (W-BLUP), designed to treat the effects of known functional markers more appropriately, proved to increase the accuracy of prediction for both traits and thus closes the gap between marker-assisted and genomic selection.
authors: Department of Cytogenetics and Genome Analysis, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany.
authors: Y
authors: Y
authors: Zhao
authors: Department of Cytogenetics and Genome Analysis, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany.
authors: M F
authors: MF
authors: Mette
authors: State Plant Breeding Institute, University of Hohenheim, Stuttgart, Germany.
authors: M
authors: M
authors: Gowda
authors: State Plant Breeding Institute, University of Hohenheim, Stuttgart, Germany.
authors: C F H
authors: CF
authors: Longin
authors: Department of Cytogenetics and Genome Analysis, Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben, Germany.
authors: J C
authors: JC
authors: Reif
mesh_terms: D000483:Alleles; D001947:Breeding; D066264:Datasets as Topic; D005819:Genetic Markers; D014644:Genetic Variation; D018745:Genome, Plant; D005838:Genotype; D006824:Hybridization, Genetic; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D015203:Reproducibility of Results; D012641:Selection, Genetic; D014908:Triticum / Q000235:genetics*
chemical_list: D005819:Genetic Markers