title: Polysaccharide based hydrogels as controlled drug delivery system for GIT cancer.
abstract: Keeping in view the anticancer nature of psyllium and methotrexate, psyllium, if suitably tailored to prepare the hydrogels, can act as the potential candidate for the slow drug delivery systems for GI tract. Therefore, the present study is an attempt to modify the psyllium for developing the hydrogels meant for delivery of methotrexate in controlled and sustained manner. The present article discusses the synthesis and characterization of the psy-cl-poly(AAm-co-AAc) hydrogels prepared by chemical crosslinking methods. These hydrogels have been characterized with SEMs, FTIR, TGA, XRD and swelling studies. The swelling and drug release behavior of hydrogels has been determined in solution of different pH. The results indicate that the drug release from the polymeric matrix follows Fickian diffusion mechanism in pH 7.4 buffer.
authors: Department of Chemistry, Himachal Pradesh University, Shimla 171005, India. Electronic address: baljitsinghhpu@yahoo.com.
authors: Baljit
authors: B
authors: Singh
authors: Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
authors: R
authors: R
authors: Bala
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy*; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D011134:Polysaccharides / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry; D013696:Temperature
chemical_list: D000178:Acrylamides; D000970:Antineoplastic Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D020100:Hydrogels; D011134:Polysaccharides; C431184:poly(acrylamide-co-acrylic acid); D012965:Sodium Chloride
keywords: Hydrogels; Methotrexate; Polysaccharide; Slow drug delivery