title: Pseudotumoral brain lesion as the presenting feature of primary Sjögren's syndrome.
abstract: BACKGROUND
  The frequency and type of central nervous system involvement in primary Sjögren's syndrome (pSS) remain controversial. Brain magnetic resonance imaging (MRI) abnormalities in pSS are usually discrete hyperintense areas in the white matter. Tumefactive brain lesions have been rarely reported.
  
  
  METHODS
  We describe a 31-year-old woman who exhibited transcortical motor aphasia, hemiparesis and partial motor seizures as the initial manifestation of pSS. Brain MRI revealed a large frontoparietal lesion extending into the corpus callosum. The patient had spontaneous recovery and developed sicca symptoms 6 months after onset. Primary SS was diagnosed on the basis of clinical features, abnormal Schirmer test findings, high levels of anti-La/SSB antibodies and positive salivary gland biopsy results.
  
  
  CONCLUSIONS
  The present case suggests that a pseudotumoral brain lesion can occur as an initial symptom of pSS.
authors: National Institute Mongi Ben Hmida of Neurology, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia. Electronic address: bensassisam@yahoo.fr.
authors: Samia Ben
authors: SB
authors: Sassi
authors: National Institute Mongi Ben Hmida of Neurology, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
authors: Fatma
authors: F
authors: Nabli
authors: National Institute Mongi Ben Hmida of Neurology, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
authors: Adnene
authors: A
authors: Boubaker
authors: Department of Internal Medicine, La Rabta Hospital, Tunisia.
authors: Imed Ben
authors: IB
authors: Ghorbel
authors: National Institute Mongi Ben Hmida of Neurology, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
authors: Sonia
authors: S
authors: Neji
authors: National Institute Mongi Ben Hmida of Neurology, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
authors: Fayçal
authors: F
authors: Hentati
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis*
keywords: Auto-immune disease; Brain magnetic resonance imaging; Central nervous system; Connective tissue disease; Pseudotumoral; Sjögren's syndrome