title: The significance of HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in a Turkish population with non-small cell lung cancer.
abstract: OBJECTIVE
  Heat-shock proteins (HSPs) are molecular chaperones which modify the structures and interactions of other proteins. The aim of our study was to investigate HSP90AA1, HSP90AB1 and HSP90B1 gene polymorphisms in patients with non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Ninety-seven patients with NSCLC and 97 healthy controls were included in the study. Real-time polymerase chain reaction was used for genotyping.
  
  
  RESULTS
  The frequency of mutant CC genotype for HSP90AA1 (rs4947C/T), mutant AA genotype for HSP90AB1 (rs13296A/G) and mutant CC genotype for HSP90B1 (rs2070908 C/G) was significantly higher in the patient group than in controls (p=0.019, p=0.004 and p=0.036, respectively). The frequency of patients with homozygote mutant allele was also significantly higher than that of controls and possessing of the mutant genotype increased the risk for disease by approximately 2.9, 4.8, 1.9 for HSP90AA1, HSP90AB1 and HSP90B1, respectively. The present study appears to be the first of its kind to report data on these gene polymorphisms in patients with NSCLC in the Turkish population.
authors: Yedikule Chest Disease and Surgery Training and Research Hospital, Third clinic, Zeytinburnu, Istanbul, Turkey. pinary70@yahoo.com.
authors: Ender
authors: E
authors: Coskunpinar
authors: Nergiz
authors: N
authors: Akkaya
authors: Pinar
authors: P
authors: Yildiz
authors: Yasemin Musteri
authors: YM
authors: Oltulu
authors: Engin
authors: E
authors: Aynaci
authors: Turgay
authors: T
authors: Isbir
authors: Ilhan
authors: I
authors: Yaylim
mesh_terms: D000483:Alleles; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005838:Genotype; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D018841:HSP90 Heat-Shock Proteins; C112969:HSP90AA1 protein, human; C493165:HSP90AB1 protein, human; D008562:Membrane Glycoproteins; C053387:endoplasmin
keywords: HSP90AA1; HSP90AB1; HSP90B1; NSCLC; SNPs; Turkish population