title: Pathophysiology of gastroesophageal reflux disease.
abstract: Gastroesophageal reflux disease (GERD) is one of the most common digestive diseases in the Western world, with typical symptoms, such as heartburn, regurgitation, or retrosternal pain, reported by 15% to 20% of the general population. The pathophysiology of GERD is multifactorial. Our understanding of these factors has significantly improved in recent years, with increased understanding of the acid pocket and hiatal hernia and how these factors interact. Although our insight has significantly increased over the past years, more studies are required to better understand symptom generation in GERD, especially in patients with therapy-resistant symptoms.
authors: Department of Gastroenterology, Translational Research Center for Gastrointestinal Disorders (TARGID), University Hospital of Leuven, University of Leuven, Herestraat 49, Leuven 3000, Belgium. Electronic address: guy.boeckxstaens@med.kuleuven.be.
authors: Guy E
authors: GE
authors: Boeckxstaens
authors: Department of Gastroenterology and Hepatology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
authors: Wout O
authors: WO
authors: Rohof
mesh_terms: D004943:Esophagogastric Junction / Q000503:physiopathology*; D004947:Esophagus / Q000473:pathology / Q000503:physiopathology; D005764:Gastroesophageal Reflux / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology
keywords: Esophageal sphincter; Esophagogastric junction; Gastroesophageal reflux disease; Pathophysiology