title: CTLA-4 polymorphisms and susceptibility to inflammatory bowel disease: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to explore whether the cytotoxic T lymphocyte associated antigen-4 (CTLA-4) polymorphisms are associated with susceptibility to ulcerative colitis (UC) and Crohn's disease (CD).
  
  
  METHODS
  The authors conducted a meta-analysis on associations between CTLA-4 +49 A/G, -318 C/T, CT60 A/G polymorphisms, and (AT)n repeat in the 3' untranslated region (UTR) and UC and CD susceptibility.
  
  
  RESULTS
  A total of 15 comparison studies were considered in our meta-analysis. Meta-analysis revealed no association between UC and the CTLA-4 +49 G and CTLA-4 -318 T alleles in all subjects (OR=0.982, 95% CI=0.851-1.1339, p=0.804; OR=0.500, 95% CI=0.223-1.124, p=0.094). No association was found between UC and the CTLA-4 CT60 A/G polymorphism in Europeans. However, a significant association was observed between the longer allele (⩾118bp) of the (AT)n and UC in Asian population (OR=6.073, 95% CI=4.246-8.684, p=1.0×10(-9)). Meta-analysis of the CTLA-4 +49 A/G, -318 C/T, CT60 A/G polymorphisms showed no association with CD.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that the CTLA-4 (AT)n repeat in 3' UTR may be associated with susceptibility to UC in Asians, while no association was found between the CTLA-4 +49 A/G, -318 C/T, and CD60 A/G polymorphism and susceptibility to UC and CD.
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address: lyhcgh@korea.ac.kr.
authors: Young Ho
authors: YH
authors: Lee
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
authors: Jae-Hoon
authors: JH
authors: Kim
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
authors: Young Ho
authors: YH
authors: Seo
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
authors: Sung Jae
authors: SJ
authors: Choi
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
authors: Jong Dae
authors: JD
authors: Ji
authors: Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
authors: Gwan Gyu
authors: GG
authors: Song
mesh_terms: D020413:3' Untranslated Regions; D000483:Alleles; D060908:CTLA-4 Antigen / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D018895:Microsatellite Repeats / Q000235:genetics; D016017:Odds Ratio; D011110:Polymorphism, Genetic
chemical_list: D020413:3' Untranslated Regions; D060908:CTLA-4 Antigen