title: Biomarkers of cardiovascular remodeling in patients on peritoneal dialysis.
abstract: OBJECTIVE
  The purpose of this study was to determine endothelin (ET)-1 and nitric oxide (NO) serum concentration levels at baseline and after 1 year of peritoneal dialysis (PD) treatment. A further aim was to evaluate the association between ET-1 and NO with parameters of echocardiography and the common carotid artery (CCA) ultrasound, and to assess their impact on cardiovascular remodeling. We also aimed to evaluate the influence of dialysis adequacy and residual renal function (RRF) on cardiovascular remodeling.
  
  
  METHODS
  This study included 40 PD patients in whom we measured serum ET-1 and NO concentrations, echocardiography and CCA ultrasound parameters.
  
  
  RESULTS
  ET-1 decreased and NO serum concentration levels increased (p < 0.01) after 12 months of PD treatment compared to baseline values. Left ventricular (LV) hypertrophy was observed in 77.5% of patients at baseline with significant reduction in LV mass index (LVMI), CCA intima media thickness (IMT) and plaque score after 12 months of PD treatment (p < 0.001). The dialysis adequacy and RRF were significantly associated with LVMI and CCA IMT after 12 months on PD.
  
  
  CONCLUSIONS
  In our study, ET-1 significantly decreased while NO increased during PD treatment and both were independently related to the cardiovascular remodeling parameters in PD patients.
authors: Clinic for Nephrology, University of Sarajevo Clinical Center, Sarajevo, Bosnia and Herzegovina.
authors: Damir
authors: D
authors: Rebić
authors: Senija
authors: S
authors: Rašić
authors: Amina
authors: A
authors: Valjevac
authors: Snežana
authors: S
authors: Unčanin
authors: Aida
authors: A
authors: Hamzić-Mehmedbašić
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002340:Carotid Artery Diseases / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood* / Q000150:complications* / Q000000981:diagnostic imaging; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D010530:Peritoneal Dialysis; D011446:Prospective Studies; D014463:Ultrasonography; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015415:Biomarkers; D019332:Endothelin-1; D009569:Nitric Oxide