title: Treatment with Rhizoma Dioscoreae extract has protective effect on osteopenia in ovariectomized rats.
abstract: The aims of this study were to evaluate the osteoprotective effect of aqueous extract from Rhizoma Dioscoreae (RDE) on rats with ovariectomy- (OVX-) induced osteopenia. Our results show that RDE could inhibit bone loss of OVX rats after a 12-week treatment. The microarray analysis showed that 68 genes were upregulated and that 100 genes were downregulated in femurs of the RDE group rats compared to those in the OVX group. The Ingenuity Pathway Analysis (IPA) showed that several downregulated genes had the potential to code for proteins that were involved in the Wnt/ β -catenin signaling pathway (Sost, Lrp6, Tcf7l2, and Alpl) and the RANKL/RANK signaling pathway (Map2k6 and Nfatc4). These results revealed that the mechanism for an antiosteopenic effect of RDE might lie in the synchronous inhibitory effects on both the bone formation and the bone resorption, which is associated with modulating the Wnt/ β -catenin signaling and the RANKL/RANK signaling.
authors: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Zhiguo
authors: 0000-0001-8626-8611
authors: Z
authors: Zhang
authors: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Lihua
authors: L
authors: Xiang
authors: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Dong
authors: D
authors: Bai
authors: Clinical Medical College of Chinese and Western Medicine, Shaanxi University of Chinese Medicine, Xi'an 712046, China.
authors: Xiaowei
authors: X
authors: Fu
authors: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Wenlai
authors: W
authors: Wang
authors: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Yan
authors: Y
authors: Li
authors: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Hong
authors: H
authors: Liu
authors: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Jinghua
authors: J
authors: Pan
authors: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors: Ya'nan
authors: Y
authors: Li
authors: Functional Genomics and Proteomics Laboratory, Osteoporosis Research Center, Creighton University Medical Center, 601 North 30th Street, Suite 6730, Omaha, NE 68131, USA.
authors: Gary Guishan
authors: GG
authors: Xiao
authors: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China ; Institute of Basic Theory, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China.
authors: Dahong
authors: D
authors: Ju
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000473:pathology / Q000517:prevention & control*; D027742:Dioscorea; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D010052:Ovariectomy / Q000009:adverse effects*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D027343:Rhizome; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal