title: Duffy blood group genotypes among malaria Plasmodium vivax patients of Baoulch population in Southeastern Iran.
abstract: OBJECTIVE
  To determine the distribution of Duffy blood group genotypes in Balouch population as a major ethnic group that living in a sub-tropical area in south East of Iran.
  
  
  METHODS
  In this study, the Duffy blood group FY phenotypes were determined using indirect anti-globulin technique and also genotype by PCR-RFLP in 160 vivax malaria patients and 160 control individuals.
  
  
  RESULTS
  The results showed that the most common Duffy genotype was FYA/FYB (46.6%) followed by FYA/FYA (15.3%), FYA/FYO (14.4%), FYB/FYO (11.9%), FYB/FYB (10%) and FYO/FYO (1.9%). In case individuals, frequency of FYA, FYB and FYO alleles were 0.471, 0.431 and 0.097, respectively compaired to 0.444, 0.353 and 0.203, respectively in control (non-infected) group.
  
  
  CONCLUSIONS
  This data provide evidence that individuals with the FYA/FYB genotype have higher susceptibility to malaria and there are significant associations between Duffy blood group variants and susceptibility or resistance to vivax malaria.
authors: Genetics of Non-Communicable Disease Research Centre, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Genetics, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address: moghaddam4@yahoo.com.
authors: Ebrahim
authors: E
authors: Miri-Moghaddam
authors: Infections and Tropical Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Zakaria
authors: Z
authors: Bameri
authors: Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
authors: Mehdi
authors: M
authors: Mohamadi
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004375:Duffy Blood-Group System / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007492:Iran; D016780:Malaria, Vivax / Q000097:blood / Q000235:genetics*; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D004375:Duffy Blood-Group System
keywords: Allele; Balouch; Duffy Blood group; Genotype; Iran; Malaria; Plasmodium vivax; Vivax