title: mTORC1: turning off is just as important as turning on.
abstract: mTORC1 is activated primarily on the lysosome. Menon et al. and Demetriades et al. show that mTORC1 deactivation on the lysosome is determined by recruitment of its negative regulator, the tumor suppressor complex TSC1-TSC2. These reports highlight the importance of subcellular localization in the regulation of mTORC1.
authors: Biozentrum, University of Basel, CH4056 Basel, Switzerland.
authors: Don
authors: D
authors: Benjamin
authors: Biozentrum, University of Basel, CH4056 Basel, Switzerland. Electronic address: m.hall@unibas.ch.
authors: Michael N
authors: MN
authors: Hall
mesh_terms: D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism*; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000378:metabolism*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D007328:Insulin; D046912:Multiprotein Complexes; C000624653:TSC2 protein, human; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases