title: [Effect of transcutaneous acupoint electrical stimulation on stress in brain surgery with propofol target controlled infusion general anesthesia].
abstract: OBJECTIVE
  To study the effect of transcutaneous acupoint electrical stimulation (TAES) on stress who received propofol target controlled infusion (TCI) general anesthesia in brain surgery.
  
  
  METHODS
  Totally 40 neurosurgical patients of I-II grade (ASA grading) in our hospital were randomly divided into the TAES group (T group) and the control group (C group), 20 in each group. All patients received intravenous anesthesia by propofol TCI. The TAES intervention was adopted in those of C group. Electrodes were only applied to corresponding acupoints without electric stimulation. The arterial blood was withdrawn before TAES (T0), before anesthesia (T1), before cutting (T2), at 60 min after encephalic incision (T3), immediately after incisions suture (T4), at about 10 min after removing tracheal catheters (T5) to detect beta-endorphin (beta-EP), cortisol (COR), adrenalin (E), blood sugar (Glu). The heart rate (HR) and mean arterial pressure (MAP) were recorded. The total time of surgery, anesthesia, total infusion amount, blood lost amount, and urine amount were recorded.
  
  
  RESULTS
  In both groups, HR, MAP, COR, and E at T2 were lower than at T0 significantly (P < 0.05). beta-EP in group C at T2 was lower than at T0 significantly (P < 0.05). HR, MAP, COR in group C at T3 were higher than at T0 significantly (P < 0.05). HR, MAP, E, and Glu in group C at T4 and T5 were higher than at T0 significantly (P < 0.05). beta-EP in group T at T1 and T3 were higher than at T0 significantly (P < 0.05). HR, COR, E, Glu, and beta-EP in group T at T4 and T5 were higher than at T0 significantly (P < 0.05). Between groups, comparing with the time point T0, the amplitude of variation of MAP, COR, and E at T2 in group C were significantly less (P < 0.05); the amplitude of variation of HR, MAP, and COR at T3 in group C were less significantly, when compared with the time point T0 (P < 0.05); the amplitude of variation of HR, MAP, COR, E, and Glu at T4 and T5 in group C were less significantly, when compared with the time point T0 (P < 0.05). When comparing the two groups, the amplitude of variation of beta-EP at time points of T1, T3, T4, and T5 in group T were larger than at T0 in group C (P < 0.05).
  
  
  CONCLUSIONS
  TAES could reduce stress and stabilize the internal environment when used in brain surgery with propofol TCI general anesthesia.
authors: Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325000, China.
authors: Qun
authors: Q
authors: Wu
authors: Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325000, China.
authors: Yun-Chang
authors: YC
authors: Mo
authors: Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325000, China.
authors: Lu-Ping
authors: LP
authors: Huang
authors: Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325000, China.
authors: Liang
authors: L
authors: Luo
authors: Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical University, Zhejiang 325000, China.
authors: Jun-Lu
authors: JL
authors: Wang
mesh_terms: D015669:Acupuncture Points; D000328:Adult; D000368:Aged; D003399:Craniotomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*; D013313:Stress Disorders, Post-Traumatic; D004561:Transcutaneous Electric Nerve Stimulation
chemical_list: D015742:Propofol