title: Sphingosin 1-phosphate contributes in tumor progression.
abstract: Sphingosine-1 phosphate (S1P) is a bioactive lipid that mediates diverse cellular responses. Signaling of S1P is carried out by a family of G-protein coupled receptors (GPCRs), which show differential expression patterns depending on tissue and cell types. Activation of S1P receptors induces signaling pathway, which can subsequently lead to physiological process. Intercellular S1P concentration is regulated and determined by several enzymes including S1P lyase, S1P kinase and S1P phosphatase. Numerous studies showed the role of S1P in malignant behavior of cancer cells including breast, lung, colon, and leukemia cell lines. In the past decade, extensive research activities have focused on elucidating S1P signaling pathway, its receptors, enzymes involved in S1P metabolism, and its performance in cancer biology. In this review, we will explain the function of S1P in tumor progression that demonstrated in past research articles and we will express its importance as a target for designing futuristic anticancer drug.
authors: Maryam
authors: M
authors: Tabasinezhad
authors: Department of Medical Biotechnology, Faculty of Advanced Medical Sciences; Research Center for Pharmaceutical Nanotechnology; Department of Biochemistry and Clinical Laboratories, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Nasser
authors: N
authors: Samadi
authors: Parisa
authors: P
authors: Ghanbari
authors: Mahsa
authors: M
authors: Mohseni
authors: Amir Ata
authors: AA
authors: Saei
authors: Simin
authors: S
authors: Sharifi
authors: Nazli
authors: N
authors: Saeedi
authors: Abolfazl
authors: A
authors: Pourhassan
mesh_terms: D002465:Cell Movement; D049109:Cell Proliferation; D018450:Disease Progression; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism / Q000502:physiology*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009362:Neoplasm Metastasis / Q000473:pathology; D009369:Neoplasms / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology; D049349:Receptors, Lysosphingolipid / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000502:physiology
chemical_list: D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine