title: Endosomal compartment: Also a dock for MHC class I peptide loading.
abstract: The endosomal compartment, which contains all the components required for loading peptides onto MHC class II molecules, is classically considered to be dedicated to the loading of MHC class II but not MHC class I molecules. However, a report in this issue of the European Journal of Immunology [Eur. J. Immunol. 2014. 44: 774-784], together with other recent studies, shows that the endosomal compartment also supports efficient loading of MHC class I molecules. These results bring a new perspective on the crosstalk between the MHC class II and MHC class I antigen-processing pathways, and may inspire new ideas for the design of vaccines against viruses and tumors.
authors: Ludwig Institute for Cancer Research, de Duve Institute, WELBIO (Walloon Excellence in Life Sciences and Biotechnology), Université catholique de Louvain, Brussels, Belgium.
authors: Wenbin
authors: W
authors: Ma
authors: Benoît J
authors: BJ
authors: Van den Eynde
mesh_terms: D017951:Antigen Presentation; D000941:Antigens / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D010455:Peptides / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D000941:Antigens; D000944:Antigens, Differentiation, B-Lymphocyte; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D010455:Peptides; C045084:invariant chain
keywords: Antigen presentation/processing; CD8+ T cells; MHC; Vaccination