title: Multifunctional Biomaterial Matrix for Advanced Wound Healing.
abstract: BACKGROUND
  Modern wound dressings provide a moist healing environment and facilitate faster and higher quality of healing. A new semi-interpenetrating network (sIPN) biomaterial platform based on poly(ethylene glycol) (PEG) and gelatin was developed as a multi-functional matrix for wound care.
  
  
  OBJECTIVE
  Besides providing a moist environment and facilitating the healing process, advanced wound dressings may be designed to serve as delivery matrices for drugs and therapeutic cells. New and effective treatments should also comply with clinical settings and be easy to use. No single treatment exists today that can fulfill all these requirements; however, advancement in multifunctional biomaterial design and development holds promise to fill this technology gap.
  PEG + gelatin sIPN provides an ideal platform for fundamental research in cell-cell and cell-biomaterial interaction that is important in wound healing. Thein situforming ability of sIPN facilitates its use in large and irregular wounds with complex contours and crevices.
  Although various commercially available wound dressings have been produced, a low-cost, easy-to-use, and biofunctionalizable biomaterial that provides a moist environment and facilitates healing is still a target of active tissue regeneration research.
  
  
  CONCLUSIONS
  Extensive preclinical data support the use ofin situpolymerized sIPN in advanced wound care.
authors: Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin. ; Department of Biomedical Engineering, College of Biomedical Engineering and Instrumental Science, Zhejiang University , People's Republic of China .
authors: Kedi
authors: K
authors: Xu
authors: Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin.
authors: Kyle R
authors: KR
authors: Kleinbeck
authors: Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison , Madison, Wisconsin. ; Department of Biomedical Engineering, College of Engineering, University of Wisconsin-Madison , Madison, Wisconsin. ; Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison , Madison, Wisconsin.
authors: Weiyuan John
authors: WJ
authors: Kao