title: A comparative study on root canal repair materials: a cytocompatibility assessment in L929 and MG63 cells.
abstract: Cytocompatibility of repair materials plays a significant role in the success of root canal repair. We conducted a comparative study on the cytocompatibility among iRoot BP Plus, iRoot FS, ProRoot MTA, and Super-EBA in L929 cells and MG63 cells. The results revealed that iRoot FS was able to completely solidify within 1 hour. iRoot BP Plus required 7-day incubation, which was much longer than expected (2 hours), to completely set. ProRoot MTA and Super-EBA exhibited a similar setting duration of 12 hours. All the materials except Super-EBA possessed negligible in vitro cytotoxicity. iRoot FS had the best cell adhesion capacity in both L929 and MG63 cells. With rapid setting, negligible cytotoxicity, and enhanced cell adhesion capacity, iRoot FS demonstrated great potential in clinical applications. Future work should focus on longer-term in vitro cytocompatibility and an in vivo assessment.
authors: State Key Laboratory of Oral Diseases Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors: Yuqing
authors: Y
authors: Jiang
authors: State Key Laboratory of Oral Diseases Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors: Qinghua
authors: Q
authors: Zheng
authors: State Key Laboratory of Oral Diseases Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors: Xuedong
authors: X
authors: Zhou
authors: State Key Laboratory of Oral Diseases Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors: Yuan
authors: Y
authors: Gao
authors: State Key Laboratory of Oral Diseases Department of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
authors: Dingming
authors: D
authors: Huang
mesh_terms: D001672:Biocompatible Materials; D002448:Cell Adhesion; D002460:Cell Line; D002470:Cell Survival; D006801:Humans; D008422:Materials Testing; D012387:Root Canal Filling Materials; D012390:Root Canal Therapy
chemical_list: D001672:Biocompatible Materials; D012387:Root Canal Filling Materials