title: Preparation of multilayered polymeric structures using a novel four-needle coaxial electrohydrodynamic device.
abstract: Coaxial four-needle electrohydrodynamic forming is applied for the first time to prepare layered structures in both particle and fiber form. Four different biocompatible polymers, polyethylene glycol, poly (lactic-co-glycolic acid), polycaprolactone, and polymethylsilsesquioxane, are used to generate four distinct layers confirmed using transmission and scanning electron microscopy combined with focused ion beam milling. The incorporation and release of different dyes within the polymeric system of four layers are demonstrated, something that is much desired in modern applications such as the polypill where multiple active pharmaceutical ingredients can be combined to treat numerous diseases.
authors: Department of Mechanical Engineering, Biomaterials Research Lab, University College London, Torrington Place, London, WC1 7JE, UK.
authors: Sheyda
authors: S
authors: Labbaf
authors: Hanif
authors: H
authors: Ghanbar
authors: Eleanor
authors: E
authors: Stride
authors: Mohan
authors: M
authors: Edirisinghe
mesh_terms: D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D009339:Needles; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D011108:Polymers
keywords: coaxial device; electrohydrodynamic; multilayered structures; polymers