title: Dynamics of Transforming Growth Factor Beta Signaling in Wound Healing and Scarring.
abstract: CONCLUSIONS
  Wound healing is an intricate biological process in which the skin, or any other tissue, repairs itself after injury. Normal wound healing relies on the appropriate levels of cytokines and growth factors to ensure that cellular responses are mediated in a coordinated manner. Among the many growth factors studied in the context of wound healing, transforming growth factor beta (TGF-β) is thought to have the broadest spectrum of effects.
  
  
  BACKGROUND
  Many of the molecular mechanisms underlying the TGF-β/Smad signaling pathway have been elucidated, and the role of TGF-β in wound healing has been well characterized. Targeting the TGF-β signaling pathway using therapeutic agents to improve wound healing and/or reduce scarring has been successful in pre-clinical studies.
  
  
  RESULTS
  Although TGF-β isoforms (β1, β2, β3) signal through the same cell surface receptors, they display distinct functions during wound healingin vivothrough mechanisms that have not been fully elucidated. The challenge of translating preclinical studies targeting the TGF-β signaling pathway to a clinical setting may require more extensive preclinical research using animal models that more closely mimic wound healing and scarring in humans, and taking into account the spatial, temporal, and cell-type-specific aspects of TGF-β isoform expression and function.
  
  
  CONCLUSIONS
  Understanding the differences in TGF-β isoform signaling at the molecular level and identification of novel components of the TGF-β signaling pathway that critically regulate wound healing may lead to the discovery of potential therapeutic targets for treatment of impaired wound healing and pathological scarring.
authors: Division of Plastic Surgery, Department of Surgery, Montreal General Hospital, McGill University , Montreal, Canada .
authors: Kenneth W
authors: KW
authors: Finnson
authors: Department of Physiology and Pharmacology, Western University , London, Canada .
authors: Sarah
authors: S
authors: McLean
authors: Department of Physiology and Pharmacology, Western University , London, Canada .
authors: Gianni M
authors: GM
authors: Di Guglielmo
authors: Division of Plastic Surgery, Department of Surgery, Montreal General Hospital, McGill University , Montreal, Canada .
authors: Anie
authors: A
authors: Philip