title: Biosynthesis with fluorine.
abstract: No longer in-F-able: fluorine building blocks can be used in polyketide biosynthesis. This represents a more flexible approach to organofluorines than the traditional use of fluorinated starter units in multistep organic syntheses, and will hopefully increase the number of compounds available for drug development.
authors: Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitässtraße 150, 44780 Bochum (Germany).
authors: Stephan
authors: S
authors: Klopries
authors: Kyra R M
authors: KR
authors: Koopmans
authors: Elsa
authors: E
authors: Sanchez-Garcia
authors: Frank
authors: F
authors: Schulz
mesh_terms: D055162:Biocatalysis; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D003065:Coenzyme A / Q000378:metabolism; D005461:Fluorine / Q000737:chemistry*; D054879:Halogenation; D008314:Malonates / Q000737:chemistry / Q000378:metabolism; D048630:Polyketide Synthases / Q000378:metabolism; D061065:Polyketides / Q000737:chemistry / Q000378:metabolism
chemical_list: D001688:Biological Products; D008314:Malonates; D061065:Polyketides; D005461:Fluorine; D048630:Polyketide Synthases; C030290:malonic acid; D003065:Coenzyme A
keywords: biocatalysis; biosynthesis; enzymes; fluorine; polyketides