title: A geometric scaling model for assessing the impact of aneurysm size ratio on hemodynamic characteristics.
abstract: BACKGROUND
  The intracranial aneurysm (IA) size has been proved to have impacts on the hemodynamics and can be applied for the prediction of IA rupture risk. Although the relationship between aspect ratio and hemodynamic parameters was investigated using real patients and virtual models, few studies focused on longitudinal experiments of IAs based on patient-specific aneurysm models. We attempted to do longitudinal simulation experiments of IAs by developing a series of scaled models.
  
  
  METHODS
  In this work, a novel scaling approach was proposed to create IA models with different aneurysm size ratios (ASRs) defined as IA height divided by average neck diameter from a patient-specific aneurysm model and the relationship between the ASR and hemodynamics was explored based on a simulated longitudinal experiment. Wall shear stress, flow patterns and vessel wall displacement were computed from these models. Pearson correlation analysis was performed to elucidate the relationship between the ASR and wall shear stress. The correlation of the ASR and flow velocity was also computed and analyzed.
  
  
  RESULTS
  The experiment results showed that there was a significant increase in IA area exposed to low WSS once the ASR > 0.7, and the flow became slower and the blood was more difficult to flow into the aneurysm as the ASR increased. Meanwhile, the results also indicated that average blood flow velocity and WSS had strongly negative correlations with the ASR (r = -0.938 and -0.925, respectively). A narrower impingement region and a more concentrated inflow jet appeared as the ASR increased, and the large local deformation at aneurysm apex could be found as the ASR >1.7 or 0.7 < the ASR <1.0.
  
  
  CONCLUSIONS
  Hemodynamic characteristics varied with the ASR. Besides, it is helpful to further explore the relationship between morphologies and hemodynamics based on a longitudinal simulation by building a series of patient-specific aneurysm scaled models applying our proposed IA scaling algorithm.
authors: Yunling
authors: Y
authors: Long
authors: Hongyu
authors: H
authors: Yu
authors: Zhizheng
authors: Z
authors: Zhuo
authors: Ying
authors: Y
authors: Zhang
authors: Yang
authors: Y
authors: Wang
authors: Xinjian
authors: X
authors: Yang
authors: School of Biomedical Engineering, Capital Medical University, Beijing 100069, China. haiyunli@ccmu.edu.cn.
authors: Haiyun
authors: H
authors: Li
mesh_terms: D001808:Blood Vessels / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D002532:Intracranial Aneurysm / Q000503:physiopathology*; D008954:Models, Biological; D057285:Precision Medicine; D033081:Shear Strength; D013314:Stress, Mechanical