title: 25-Hydroxyvitamin D levels and acute cellular rejection in liver transplant patients.
abstract: OBJECTIVE
  To investigate the association between 25-hydroxyvitamin D [25(OH)D] levels prior to liver transplantation (LT) and the development of acute cellular rejection (ACR) within the first year post LT.
  
  
  METHODS
  This retrospective study included 275 consecutive LTs performed in 262 patients at Mayo Clinic in Jacksonville, Florida over 13 months. A total of 149 patients met the inclusion criteria. The correlations between 25(OH)D levels and the development, severity, and number of biopsy-proven ACR episodes were assessed.
  
  
  RESULTS
  The prevalence of 25(OH)D levels <30 ng/mL was 92%. No association was found between pre LT 25(OH)D levels and the diagnosis of ACR (P = .61). Mean ± SD pre LT 25(OH)D levels were 16.1 ± 6.8 ng/mL for 48 subjects with no rejection, 16.1 ± 8.2 ng/mL for those with a mild first episode of ACR (n = 58), and 18.4 ± 12.4 ng/mL for those who experienced a moderate/severe first ACR (n = 39). However, in a subgroup analysis of patients with 25(OH)D levels <30 ng/mL, there was a statistically significant negative correlation (P = .0252) between 25(OH) D level and the ACR rate.
  
  
  CONCLUSIONS
  Vitamin D insufficiency and deficiency prior to LT was prevalent in our cohort. There was no statistically significant association between low 25(OH)D levels and the diagnosis or severity of ACR or the number of rejection episodes within the first year post LT. However, there was a negative correlation between 25(OH)D levels below 30 ng/mL and the rate of ACR within 1 year post LT.
authors: Division of Endocrinology, Department of Medicine, University of Florida-Jacksonville, Florida.
authors: Mae
authors: M
authors: Sheikh-Ali
authors: Department of Transplant, Mayo Clinic, Jacksonville, Florida.
authors: Andrew P
authors: AP
authors: Keaveny
authors: Division of Endocrinology, Department of Medicine, University of Florida-Jacksonville, Florida.
authors: Ayham
authors: A
authors: Chamseddin
authors: Endocrinology, Biomedical Research of New Mexico, New Mexico VA Health Care System, Albuquerque, New Mexico.
authors: Lina
authors: L
authors: Aguirre
authors: Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, Minnesota.
authors: Bart
authors: B
authors: Clarke
authors: Division of Endocrinology, Department of Medicine, Mayo Clinic, Jacksonville, Florida.
authors: Shon
authors: S
authors: Meek
mesh_terms: D000208:Acute Disease; D005260:Female; D006084:Graft Rejection / Q000097:blood*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D