title: Serum gamma-glutamyl transferase levels and in-hospital mortality in patients with acute heart failure.
abstract: BACKGROUND
  Acute heart failure (AHF) is a major cause of hospitalisation, morbidity and mortality worldwide. Gamma-glutamyl transferase (GGT) is an enzyme responsible for the extracellular catabolism of antioxidant glutathione and a potential risk indicator of cardiac mortality. Limited data exists on the prognostic value of circulating levels of GGT in patients hospitalized due to AHF.
  
  
  OBJECTIVE
  To study the association between baseline GGT activity and in-hospital mortality in AHF patients.
  
  
  METHODS
  The study cohort consisted of 183 AHF patients with left ventricular ejection fraction (LVEF) < 50%. The primary endpoint was in-hospital mortality. Patients were divided into two groups according to in-hospital mortality. The relationship between GGT activity and in-hospital mortality was tested using logistic regression models, adjusting for clinical characteristics and echocardiographic findings.
  
  
  RESULTS
  After adjustment for possible confounders, GGT level was significantly related (OR 1.056, 95% CI 1.018-1.096, p = 0.04) to in-hospital mortality.
  
  
  CONCLUSIONS
  Elevated GGT activity is an independent predictor of short-term mortality in patients with AHF and reduced LVEF.
authors: Department of Cardiology, Bezmialem Vakif University, Turcja. turphan@gmail.com.
authors: Murat
authors: M
authors: Turfan
authors: Abdurrahman
authors: A
authors: Tasal
authors: Ercan
authors: E
authors: Erdogan
authors: Mehmet Akıf
authors: MA
authors: Vatankulu
authors: Parviz
authors: P
authors: Jafarov
authors: Osman
authors: O
authors: Sonmez
authors: Gokhan
authors: G
authors: Ertas
authors: Ahmet
authors: A
authors: Bacaksız
authors: Mehmet
authors: M
authors: Ergelen
authors: Omer
authors: O
authors: Goktekın
mesh_terms: D000208:Acute Disease; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000201:enzymology* / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D005723:gamma-Glutamyltransferase