title: Endocrinological analysis of endothelium-dependent vasodilation in middle-aged patients with impaired glucose tolerance during prediabetes mellitus.
abstract: Impaired glucose tolerance (IGT) is a pre-diabetic metabolic state involving heterogeneous and dynamic changes between the normal and diabetic state. The present study aimed to investigate the endocrine regulation of endothelium-dependent dysfunction in middle-aged patients with IGT and in patients with a normal glucose tolerance (NGT). An oral glucose tolerance test was performed to determine the NGT and IGT states. Physiological and biochemical analyses were performed. The carotid artery structure and function were investigated with Doppler supersonic diagnostic equipment. The functioning of the vascular endothelium was analyzed with physiological and biochemical indices in the IGT group. The results showed a significant reduction in endothelium-dependent vasodilation, but not in endothelium-independent vasodilation in the IGT group compared with those of the NGT group. It was identified that the intima-media thickness of the carotid artery and expression levels of endothelin-1 were significantly higher, whereas the endothelium-derived factor C-type natriuretic peptide levels were significantly lower in the IGT group compared with those in the NGT group. Notably, significant correlations were identified between endocrinological changes and body composition, including fat and glucose metabolism, in the IGT group. Our data indicate that vascular endothelial functions may be impaired by fat and glucose metabolism and body composition in IGT patients during prediabetes mellitusare.
authors: Laboratory of Sport Physiology and Biomedicine, School of Physical Education and Sport Sciences, College of Life Sciences, Fujian Normal University, Fuzhou, Fuijian 350007, P.R. China ; Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou, Fuijian 350007, P.R. China.
authors: Yiping
authors: Y
authors: Liu
authors: Department of Ultrasound, Fujian Provincial Hospital, Provincial Clinical College of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China.
authors: Jianwei
authors: J
authors: Li
authors: Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou, Fuijian 350007, P.R. China.
authors: Zhenghong
authors: Z
authors: Zhang
authors: Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou, Fuijian 350007, P.R. China.
authors: Yedong
authors: Y
authors: Tang
authors: Laboratory of Sport Physiology and Biomedicine, School of Physical Education and Sport Sciences, College of Life Sciences, Fujian Normal University, Fuzhou, Fuijian 350007, P.R. China.
authors: Zuosong
authors: Z
authors: Chen
authors: Provincial Key Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou, Fuijian 350007, P.R. China.
authors: Zhengchao
authors: Z
authors: Wang
keywords: cardiovascular disease; diabetes mellitus; endothelium-dependent vasodilation; impaired glucose tolerance