title: Stem cell therapy for neonatal brain injury.
abstract: This article introduces the basic concepts of modeling neonatal brain injury and provides background information regarding each of the commonly used types of stem cells. It summarizes the findings of preclinical research testing the therapeutic potential of stem cells in animal models of neonatal brain injury, reports briefly on the status of clinical trials, and discusses the important ongoing issues that need to be addressed before stem cell therapy is used to repair the injured brain.
authors: Inserm U676, Paris, 75019, France; University Paris Diderot, Sorbonne Paris Cité, UMRS 676, Paris, 75019, France; PremUP, Paris, 75019, France; Department of Perinatal Imaging and Health, Department of Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, SE1 7EH, UK.
authors: Bobbi
authors: B
authors: Fleiss
authors: UCL Institute for Women's Health, University College London, London, WC1E 6HX, UK.
authors: Pascale V
authors: PV
authors: Guillot
authors: Inserm U676, Paris, 75019, France; University Paris Diderot, Sorbonne Paris Cité, UMRS 676, Paris, 75019, France; PremUP, Paris, 75019, France.
authors: Luigi
authors: L
authors: Titomanlio
authors: Inserm U676, Paris, 75019, France; University Paris Diderot, Sorbonne Paris Cité, UMRS 676, Paris, 75019, France; PremUP, Paris, 75019, France.
authors: Olivier
authors: O
authors: Baud
authors: Department of Perinatal Imaging and Health, Department of Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, SE1 7EH, UK; Department of Clinical Sciences, Sahlgrenska Academy/East Hospital, 416 85 Gothenburg, Sweden; Department of Physiology and Neuroscience, Perinatal Center, Sahlgrenska Academy, Gothenburg University, 40530, Gothenburg, Sweden.
authors: Henrik
authors: H
authors: Hagberg
authors: Inserm U676, Paris, 75019, France; University Paris Diderot, Sorbonne Paris Cité, UMRS 676, Paris, 75019, France; PremUP, Paris, 75019, France; Department of Perinatal Imaging and Health, Department of Division of Imaging Sciences and Biomedical Engineering, King's College London, King's Health Partners, St. Thomas' Hospital, London, SE1 7EH, UK. Electronic address: pierre.gressens@inserm.fr.
authors: Pierre
authors: P
authors: Gressens
mesh_terms: D000650:Amnion / Q000166:cytology; D000818:Animals; D001930:Brain Injuries / Q000628:therapy*; D003131:Combined Modality Therapy; D036101:Cord Blood Stem Cell Transplantation / Q000379:methods; D004195:Disease Models, Animal; D053595:Embryonic Stem Cells / Q000637:transplantation*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy*; D007231:Infant, Newborn; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D058953:Neural Stem Cells / Q000637:transplantation*; D010920:Placenta / Q000166:cytology; D011247:Pregnancy; D033581:Stem Cell Transplantation / Q000379:methods*
keywords: Amniotic stem cells; Cord blood; Embryonic stem cells; Mesenchymal stem cells; Neural stem cells; Neuroprotection; Placental stem cells; Stem cell therapy