title: Recurrent hepatitis B following recurrence of hepatocellular carcinoma after living donor liver transplantation.
abstract: Hepatitis B virus (HBV) recurrence after liver transplantation for HBV-associated liver diseases results in decreased patient and graft survival. Herein we have reported two cases of HBV recurrence following relapse of hepatocellular carcinoma (HCC) after living donor liver transplantation (LDLT). Both cases had LDLT for end-stage liver disease secondary to HBV infection with nodules of HCC exceeding the Milan criteria. HBV prophylaxis using hepatitis B immunoglobulin with nucleos (t) ide analogues were given and HBV DNA levels were consistently undetectable after LDLT. HCC recurred at 5 months and 13 months posttransplant respectively, and chemotherapy and radiation therapy were performed. HBV recurrence occurred during the treatment of HCC. HBV DNA levels increased despite the treatment with anti-HBV agents after HBV recurrence. In hepatitis B surface antigen positive recipients, HBV prophylaxis should be intensified during the treatment of recurrent HCC.
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Hideki
authors: H
authors: Ijichi
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Tomoharu
authors: T
authors: Yoshizumi
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Toru
authors: T
authors: Ikegami
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Yuji
authors: Y
authors: Soejima
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Tetsuo
authors: T
authors: Ikeda
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Hirofumi
authors: H
authors: Kawanaka
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Hideaki
authors: H
authors: Uchiyama
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Yo-Ichi
authors: Y
authors: Yamashita
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Masaru
authors: M
authors: Morita
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Eiji
authors: E
authors: Oki
authors: Department of Surgery, Kyushu University Beppu Hospital, Fukuoka, Japan.
authors: Koshi
authors: K
authors: Mimori
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Keishi
authors: K
authors: Sugimachi
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Hiroshi
authors: H
authors: Saeki
authors: Department of Gastroenterological Surgery, Kumamoto University, Japan.
authors: Masayuki
authors: M
authors: Watanabe
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Ken
authors: K
authors: Shirabe
authors: Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
authors: Yoshihiko
authors: Y
authors: Maehara
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage; D015415:Biomarkers / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D059248:Chemoradiotherapy; D004279:DNA, Viral / Q000097:blood; D004359:Drug Therapy, Combination; D006509:Hepatitis B / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D008113:Liver Neoplasms / Q000628:therapy*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D055502:Secondary Prevention
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens