title: NHC-catalyzed oxidative γ-addition of α,β-unsaturated aldehydes to isatins: a high-efficiency synthesis of spirocyclic oxindole-dihydropyranones.
abstract: This manuscript discloses an efficient construction of the spirocyclic oxindole-dihydropyranone scaffold via the N-heterocyclic carbene (NHC)-catalyzed oxidative γ-functionalization of α,β-unsaturated aldehydes bearing γ-H with isatin derivatives. The ready availability of the starting materials, easy work-up, mild reaction conditions and the potential utilization value of the products make this strategy attractive.
authors: School of Chemistry and Chemical Engineering, Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Xuzhou 221116, P. R. China.
authors: Rui
authors: R
authors: Liu
authors: Chenxia
authors: C
authors: Yu
authors: Zhaoxin
authors: Z
authors: Xiao
authors: Tuanjie
authors: T
authors: Li
authors: Xiangshan
authors: X
authors: Wang
authors: Yuanwei
authors: Y
authors: Xie
authors: Changsheng
authors: C
authors: Yao
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D007510:Isatin / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D000078183:Oxindoles; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000447:Aldehydes; D006571:Heterocyclic Compounds; D007211:Indoles; D000078183:Oxindoles; D011753:Pyrones; D013141:Spiro Compounds; C022960:2-oxindole; C030011:carbene; D007510:Isatin; D008697:Methane