title: Kappe neurons, a novel population of olfactory sensory neurons.
abstract: Perception of olfactory stimuli is mediated by distinct populations of olfactory sensory neurons, each with a characteristic set of morphological as well as functional parameters. Beyond two large populations of ciliated and microvillous neurons, a third population, crypt neurons, has been identified in teleost and cartilaginous fishes. We report here a novel, fourth olfactory sensory neuron population in zebrafish, which we named kappe neurons for their characteristic shape. Kappe neurons are identified by their Go-like immunoreactivity, and show a distinct spatial distribution within the olfactory epithelium, similar to, but significantly different from that of crypt neurons. Furthermore, kappe neurons project to a single identified target glomerulus within the olfactory bulb, mdg5 of the mediodorsal cluster, whereas crypt neurons are known to project exclusively to the mdg2 glomerulus. Kappe neurons are negative for established markers of ciliated, microvillous and crypt neurons, but appear to have microvilli. Kappe neurons constitute the fourth type of olfactory sensory neurons reported in teleost fishes and their existence suggests that encoding of olfactory stimuli may require a higher complexity than hitherto assumed already in the peripheral olfactory system.
authors: Institut für Genetik, Universität zu Köln, Zülpicher Str. 47a, 50674 Köln, Germany.
authors: Gaurav
authors: G
authors: Ahuja
authors: 1] Institut für Genetik, Universität zu Köln, Zülpicher Str. 47a, 50674 Köln, Germany [2].
authors: Shahrzad
authors: S
authors: Bozorg Nia
authors: 1] Institut für Genetik, Universität zu Köln, Zülpicher Str. 47a, 50674 Köln, Germany [2].
authors: Veronika
authors: V
authors: Zapilko
authors: Institut für Genetik, Universität zu Köln, Zülpicher Str. 47a, 50674 Köln, Germany.
authors: Vladimir
authors: V
authors: Shiriagin
authors: Institut für Genetik, Universität zu Köln, Zülpicher Str. 47a, 50674 Köln, Germany.
authors: Daniel
authors: D
authors: Kowatschew
authors: 1] Institut für Genetik, Universität zu Köln, Zülpicher Str. 47a, 50674 Köln, Germany [2].
authors: Yuichiro
authors: Y
authors: Oka
authors: Institut für Genetik, Universität zu Köln, Zülpicher Str. 47a, 50674 Köln, Germany.
authors: Sigrun I
authors: SI
authors: Korsching
mesh_terms: D000199:Actins / Q000276:immunology; D000818:Animals; D000906:Antibodies / Q000276:immunology; D007150:Immunohistochemistry; D009830:Olfactory Bulb / Q000502:physiology*; D055696:Olfactory Perception; D018034:Olfactory Receptor Neurons / Q000276:immunology / Q000502:physiology*; D012903:Smell; D013194:Staining and Labeling; D014404:Tubulin / Q000276:immunology; D015027:Zebrafish / Q000033:anatomy & histology* / Q000502:physiology
chemical_list: D000199:Actins; D000906:Antibodies; D014404:Tubulin