title: Effect of liver transplantation on glucose levels in patients with prediabetes or type 2 diabetes.
abstract: BACKGROUND
  Liver transplantation (LT) may induce the occurrence of diabetes mellitus. It can be speculated, however, that the LT may have a beneficial effect on glucose metabolism. We therefore conducted a study to examine the changing trends in blood glucose levels before and after LT in patients with prediabetes or type 2 diabetes.
  
  
  METHODS
  In this observational study, we enrolled 47 patients (38 prediabetes and 9 diabetes) who underwent LT. We compared the blood glucose levels between the pre-transplantation (24 months) and the post-transplantation (36 months) periods and analyzed the diverse factors affecting glucose levels.
  
  
  RESULTS
  The glucose regulation worsened and insulin dose increased in patients with diabetes, which was notably seen during the steroid maintenance period. Following steroid withdrawal, however, there was a decrease in the insulin dose in 55.6% of the patients, and 33.3% of the patients converted from insulin to oral agents. Of the patients with prediabetes, 55.3% developed new-onset diabetes after transplantation (NODAT). However, 18.4% achieved a recovery of glucose levels to normal range. Of the 21 NODAT patients, 52.4% achieved a recovery of glucose level to the prediabetes range after steroid withdrawal. There was a significant correlation between the old age and the persistence of NODAT (P < .05).
  
  
  CONCLUSIONS
  LT may have a diverse effect on glycemia, which may lead to changes in glucose control methods. Therefore, glucose metabolism after LT may need to be differentiated by the underlying glucose disturbance status and the time after LT with or without steroid maintenance period.
authors: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, South Korea.
authors: S H
authors: SH
authors: Kim
authors: Division of Endocrinology and Metabolism, Department of Internal Medicine, Jeju S-Jungang Hospital, Jeju, South Korea.
authors: J M
authors: JM
authors: Kim
authors: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, South Korea.
authors: K A
authors: KA
authors: Lee
authors: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, South Korea.
authors: T S
authors: TS
authors: Park
authors: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, South Korea.
authors: H S
authors: HS
authors: Baek
authors: Division of Surgery, Chonbuk National University Medical School, Jeonju, South Korea.
authors: H C
authors: HC
authors: Yu
authors: Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Chonbuk National University Hospital, Jeonju, South Korea. Electronic address: mdjinhy@jbnu.ac.kr.
authors: H Y
authors: HY
authors: Jin
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003430:Cross-Sectional Studies; D048909:Diabetes Complications / Q000628:therapy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D017093:Liver Failure / Q000097:blood / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood* / Q000150:complications; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007328:Insulin