title: Cognition in MCI and Alzheimer's disease: baseline data from a longitudinal study of the NTB.
abstract: Baseline data are summarized from a study examining the psychometric properties of the Neuropsychological Test Battery (NTB) and its subtests, and correlating the NTB with other cognitive and functional assessments. A multicenter, longitudinal, non-interventional study included mild to moderate Alzheimer's disease (AD, n = 196), mild cognitive impairment (MCI, n = 70), or normal cognition participants (NC, n = 75). The NTB, other cognitive assessment tools, functional/behavioral questionnaires, and health outcome assessments were administered. At baseline composite NTB, NTB memory, and NTB executive function z-scores were significantly lower for participants with AD compared with MCI, and for participants with MCI compared with NC. The composite NTB z-score had high test-retest reliability between screening and baseline. The results of this study suggest that NTB exhibits good reliability in patients with mild to moderate AD and MCI.
authors: a Metis Cognition Ltd ., Wiltshire , UK.
authors: John
authors: J
authors: Harrison
authors: Dorene M
authors: DM
authors: Rentz
authors: Trent
authors: T
authors: McLaughlin
authors: Timothy
authors: T
authors: Niecko
authors: Keith M
authors: KM
authors: Gregg
authors: Ronald S
authors: RS
authors: Black
authors: Jacqui
authors: J
authors: Buchanan
authors: Enchi
authors: E
authors: Liu
authors: Michael
authors: M
authors: Grundman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000523:psychology*; D003071:Cognition; D060825:Cognitive Dysfunction / Q000523:psychology*; D005060:Europe; D056344:Executive Function; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D011594:Psychometrics; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D014481:United States