title: Hyponatremia at autopsy: cause of death or simply a marker of severity of the underlying disease.
abstract: OBJECTIVE
  To analyze the possible interpretations of hyponatremia detected at autopsy in vitreous humor in relation to the cause of death and/or associated pathology (cause of death or a simple marker of the severity of associated diseases).
  
  
  METHODS
  Hyponatremia is the most common electrolytic disorder in hospital practice, considered as a risk factor for hospital mortality. We conducted a 3-year forensic casework analysis in view ofestablishing the relationship of hyponatremia with mortality: hyponatremia as a direct cause of death or hyponatremia caused by the severity of the underlying disease which is the cause of death.
  
  
  RESULTS
  The forensic cases are not fully reliable. Although the target question has not been answered, our findings plead for the association of hyponatremia with severe diseases (sick cell syndrome) and not for hyponatremia as a cause of death, but this does not seems to be proven either, the percentage of cases with significant hyponatremia increasing from zero in cases of trauma and sudden violent death to 50% in cases of severe chronic diseases.
  
  
  CONCLUSIONS
  The values obtained by us are in agreement with the data in the literature. Our findings plead for the scenario hyponatremia as a marker of the severity of the underlying disease.
authors: University of Medicine and Pharmacy Grigore T. Popa-lasi, Faculty of Pharmacy.
authors: S
authors: S
authors: Moldoveanu
authors: Vaslui County Forensic Service.
authors: Diana
authors: D
authors: Dorubeţ
authors: University of Medicine and Pharmacy Grigore T. Popa-lasi, Department of Medical Ethics.
authors: V
authors: V
authors: Astărăstoae
authors: University of Medicine and Pharmacy Grigore T. Popa-lasi, Faculty of Medicine, Department of Toxicology.
authors: Elena
authors: E
authors: Butnaru
mesh_terms: D000328:Adult; D000368:Aged; D001344:Autopsy; D015415:Biomarkers / Q000032:analysis; D002423:Cause of Death; D002463:Cell Membrane Permeability; D016638:Critical Illness; D016757:Death, Sudden, Cardiac / Q000209:etiology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality; D007223:Infant; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012720:Severity of Illness Index; D012964:Sodium / Q000032:analysis*; D013577:Syndrome; D014822:Vitreous Body / Q000737:chemistry
chemical_list: D015415:Biomarkers; D012964:Sodium