title: Formal and total synthesis of (±)-cycloclavine.
abstract: A ring fragmentation and intramolecular azomethine ylide 1,3-dipolar cycloaddition sequence of reactions was successfully used in the preparation of a known (±)-cycloclavine precursor in good overall yield. Results of efforts to incorporate the tetrasubstituted cyclopropane ring present in cycloclavine are also discussed.
authors: The University of Vermont, 82 University Place, Burlington, VT, 05405, United States.
authors: Nitinkumar D
authors: ND
authors: Jabre
authors: The University of Vermont, 82 University Place, Burlington, VT, 05405, United States.
authors: Teruki
authors: T
authors: Watanabe
authors: The University of Vermont, 82 University Place, Burlington, VT, 05405, United States.
authors: Matthias
authors: M
authors: Brewer
keywords: 1,3-Dipolar Cycloaddition; Cycloclavine; Ergot Alkaloid; Natural Product Synthesis; Ring Fragmentation