title: Comparative study of genotype and virulence in CTX-M-producing and non-extended-spectrum-β-lactamase-producing Klebsiella pneumoniae isolates.
abstract: Molecular and virulence characteristics of CTX-M-producing and non-extended-spectrum-β-lactamase (non-ESBL)-producing Klebsiella pneumoniae isolates were compared. Lack of shared characteristics between the two groups suggested that most CTX-M-producing K. pneumoniae isolates in South Korea did not occur by transfer of blaCTX-M into susceptible strains. Conjugation assays confirmed that the plasmid with the blaCTX-M-15 gene confers virulence as well as antimicrobial resistance, suggesting that a CTX-M-15-producing clone such as ST11 may have a selective advantage even without antibiotic pressure.
authors: Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, South Korea.
authors: Juyoun
authors: J
authors: Shin
authors: Kwan Soo
authors: KS
authors: Ko
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005838:Genotype; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D056910:Republic of Korea; D014774:Virulence / Q000235:genetics / Q000502:physiology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases