title: Extraesophageal presentations of GERD: where is the science?
abstract: This article reviews the evaluation and management of patients with suspected extraesophageal manifestations of gastroesophageal reflux disease, such as asthma, chronic cough, and laryngitis, which are commonly encountered in gastroenterology practices. Otolaryngologists and gastroenterologists commonly disagree upon the underlying cause for complaints in patients with one of the suspected extraesophageal reflux syndromes. The accuracy of diagnostic tests (laryngoscopy, endoscopy, and pH- or pH-impedance monitoring) for patients with suspected extraesophageal manifestations of gastroesophageal reflux disease is suboptimal. An empiric trial of proton pump inhibitors in patients without alarm features can help some patients, but the response to therapy is variable.
authors: Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, CB# 7080, Chapel Hill, NC 27599, USA. Electronic address: madanick@med.unc.edu.
authors: Ryan D
authors: RD
authors: Madanick
mesh_terms: D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D002908:Chronic Disease; D003371:Cough / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004945:Esophagoscopy; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007827:Laryngitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D007828:Laryngoscopy; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
chemical_list: D054328:Proton Pump Inhibitors
keywords: Asthma; Chronic cough; Diagnostic testing; Extraesophageal reflux; Gastroesophageal reflux disease; Laryngitis; Laryngopharyngeal reflux