title: Expression profiles of loneliness-associated genes for survival prediction in cancer patients.
abstract: Influence of loneliness on human survival has been established epidemiologically, but genomic research remains undeveloped. We identified 34 loneliness-associated genes which were statistically significant for high- lonely and low-lonely individuals. With the univariate Cox proportional hazards regression model, we obtained corresponding regression coefficients for loneliness-associated genes fo individual cancer patients. Furthermore, risk scores could be generated with the combination of gene expression level multiplied by corresponding regression coefficients of loneliness-associated genes. We verified that high-risk score cancer patients had shorter mean survival time than their low-risk score counterparts. Then we validated the loneliness-associated gene signature in three independent brain cancer cohorts with Kaplan-Meier survival curves (n=77, 85 and 191), significantly separable by log-rank test with hazard ratios (HR) >1 and p-values <0.0001 (HR=2.94, 3.82, and 1.78). Moreover, we validated the loneliness-associated gene signature in bone cancer (HR=5.10, p-value=4.69e-3), lung cancer (HR=2.86, p-value=4.71e-5), ovarian cancer (HR=1.97, p-value=3.11e-5), and leukemia (HR=2.06, p-value=1.79e-4) cohorts. The last lymphoma cohort proved to have an HR=3.50, p-value=1.15e-7. Loneliness- associated genes had good survival prediction for cancer patients, especially bone cancer patients. Our study provided the first indication that expression of loneliness-associated genes are related to survival time of cancer patients.
authors: Department of Computer Science and Information Engineering, National Central University, ChungLi, Taiwan E-mail : davidyou7@gmail.com.
authors: Liang-Fu
authors: LF
authors: You
authors: Jia-Rong
authors: JR
authors: Yeh
authors: Mu-Chun
authors: MC
authors: Su
mesh_terms: D001859:Bone Neoplasms / Q000235:genetics / Q000401:mortality / Q000523:psychology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007938:Leukemia / Q000235:genetics / Q000401:mortality / Q000523:psychology; D008132:Loneliness / Q000523:psychology*; D008175:Lung Neoplasms / Q000235:genetics / Q000401:mortality / Q000523:psychology; D008223:Lymphoma / Q000235:genetics / Q000401:mortality / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics* / Q000401:mortality / Q000523:psychology*; D010051:Ovarian Neoplasms / Q000235:genetics / Q000401:mortality / Q000523:psychology; D016016:Proportional Hazards Models; D011569:Psychiatric Status Rating Scales; D015996:Survival Rate; D059467:Transcriptome