title: Endogenous galanin as a novel biomarker to predict gestational diabetes mellitus.
abstract: Although a significantly higher level of plasma galanin was found in patients with gestational diabetes mellitus (GDM) in our previous study, it is unknown whether plasma galanin is biomarker for the prediction of GDM. The present study aims to further evaluate the relationship between endogenous galanin and GDM in pregnant women and to find out the precise mechanism by which galanin plays role in the pathogenesis of GDM. The study registered thirty pregnant women with GDM and thirty pregnant women with normal glucose tolerance (NGT). Demographic and biochemical parameters and fasting venous blood samples of two groups were collected from all cases. Galanin was analyzed by an enzyme-linked immunosorbent assay. Gamma-glutamyl transferase (GGT) was measured by enzymatic methods. The plasma galanin and GGT levels were found higher in GDM compared with NGT (P<0.001). In addition, a significant positive correlation was shown between galanin and fasting glucose (P=0.049), 1-h glucose (P=0.033), body mass index (BMI) (P<0.001) and GGT (P=0.048) in pregnant women with GDM, whereas there was significant positive correlation between galanin and BMI (P=0.030) in NGT group. The plasma galanin and GGT levels are higher in patients with GDM. The plasma galanin levels appear to be related to the changes of blood glucose, BMI and GTT in GDM. The higher level of galanin observed in GDM may represent a adaptation to the rise of glucose, weight, GGT associated with GDM. The higher level of plasma galanin is a novel biomarker for the prediction of GDM.
authors: Department of Endocrinology, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China; Research Institution of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors: Zhenwen
authors: Z
authors: Zhang
authors: Department of Gynaecology and Obstetrics, Yangzhou Maternal and Child Health Care Hospital, Yangzhou, Jiangsu 225001, China.
authors: Chunmei
authors: C
authors: Gu
authors: Research Institution of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors: Penghua
authors: P
authors: Fang
authors: Research Institution of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors: Mingyi
authors: M
authors: Shi
authors: Department of Endocrinology, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors: Yan
authors: Y
authors: Wang
authors: Department of Gynaecology and Obstetrics, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors: Yan
authors: Y
authors: Peng
authors: Research Institution of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China.
authors: Ping
authors: P
authors: Bo
authors: Department of Endocrinology, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China. Electronic address: yzzzw@medmail.com.cn.
authors: Yan
authors: Y
authors: Zhu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D019004:Galanin / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D011247:Pregnancy
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D019004:Galanin
keywords: GGT; Galanin; Gestational diabetes; Glucose