title: Role of Oxidative Stress on Vaginal Bleeding during The First Trimester of Pregnant Women.
abstract: BACKGROUND
  Reactive oxygen species (ROS) are produced in many metabolic and physiologic processes. Antioxidative mechanisms remove these harmful species. Our aim was to assess whether serum total antioxidant capacity and total oxidant status altered during first trimester pregnancies with vaginal bleeding.
  
  
  METHODS
  In this cross-sectional study, A group of pregnant women at less than 10 weeks of gestation with vaginal bleeding (n=25) and a control group of healthy pregnancies with similar characteristics (n=25) were included. All of the patients in the two groups were matched for age, gestational age and body mass index. Serum total antioxidant capacity and total oxidant status levels were determined using a Hitachi 912 analyzer and compared between the two groups.
  
  
  RESULTS
  Characteristics, including maternal age, parity, and gestational age were similar between the two groups. Serum total antioxidant capacity levels were significantly lower in the women with vaginal bleeding than in control women (1.16 ± 0.20 vs. 1.77 ± 0.08 mmol Trolox Equiv./L; p=0.001), whereas higher total oxidant status measurements were found in women with vaginal bleeding compared to the control group (4.01 ± 0.20 vs. 2.57 ± 0.65 µmol H2O2 Equiv./L; p=0.001).
  
  
  CONCLUSIONS
  Increased total oxidant status might be involved in the pathophysiology of vaginal bleeding during early first trimester pregnancies.
authors: Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors: Rüya
authors: R
authors: Deveer
authors: Department of Radiology, Sitki Kocman University Scool of Medicine, Mugla, Turkey.
authors: Mehmet
authors: M
authors: Deveer
authors: Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors: Yaprak
authors: Y
authors: Engin-Üstün
authors: Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors: Eren
authors: E
authors: Akbaba
authors: Departmen of Biochemistry, Fatih University Scool of Medicine, Ankara, Turkey.
authors: Sema
authors: S
authors: Uysal
authors: Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors: Esma
authors: E
authors: Sarikaya
authors: Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors: Cavidan
authors: C
authors: Gülerman
authors: Department of Gynecology and Obstetrics, Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
authors: Leyla
authors: L
authors: Mollamahmutoglu
keywords: First Trimester; Oxidative Stress; Vaginal Bleeding