title: Bacterial transformation: distribution, shared mechanisms and divergent control.
abstract: Natural bacterial transformation involves the internalization and chromosomal integration of DNA and has now been documented in ~80 species. Recent advances have established that phylogenetically distant species share conserved uptake and processing proteins but differ in the inducing cues and regulatory mechanisms that are involved. In this Review, we highlight divergent and common principles that govern the transformation process in different bacteria. We discuss how this cumulative knowledge enables the prediction of new transformable species and supports the idea that the main role of internalized DNA is in the generation of genetic diversity or in chromosome repair rather than in nutrition.
authors: 1] Centre National de la Recherche Scientifique, LMGM-UMR5100, F-31000 Toulouse, France. [2] Université de Toulouse, UPS, Laboratoire de Microbiologie et Génétique Moléculaires, F-31000 Toulouse, France.
authors: Calum
authors: C
authors: Johnston
authors: 1] Centre National de la Recherche Scientifique, LMGM-UMR5100, F-31000 Toulouse, France. [2] Université de Toulouse, UPS, Laboratoire de Microbiologie et Génétique Moléculaires, F-31000 Toulouse, France.
authors: Bernard
authors: B
authors: Martin
authors: 1] Centre National de la Recherche Scientifique, LMGM-UMR5100, F-31000 Toulouse, France. [2] Université de Toulouse, UPS, Laboratoire de Microbiologie et Génétique Moléculaires, F-31000 Toulouse, France.
authors: Gwennaele
authors: G
authors: Fichant
authors: 1] Centre National de la Recherche Scientifique, LMGM-UMR5100, F-31000 Toulouse, France. [2] Université de Toulouse, UPS, Laboratoire de Microbiologie et Génétique Moléculaires, F-31000 Toulouse, France.
authors: Patrice
authors: P
authors: Polard
authors: 1] Centre National de la Recherche Scientifique, LMGM-UMR5100, F-31000 Toulouse, France. [2] Université de Toulouse, UPS, Laboratoire de Microbiologie et Génétique Moléculaires, F-31000 Toulouse, France.
authors: Jean-Pierre
authors: JP
authors: Claverys
mesh_terms: D001419:Bacteria / Q000145:classification / Q000235:genetics*; D002876:Chromosomes, Bacterial / Q000235:genetics*; D004269:DNA, Bacterial / Q000235:genetics / Q000378:metabolism; D014644:Genetic Variation; D010802:Phylogeny; D014169:Transformation, Bacterial
chemical_list: D004269:DNA, Bacterial