title: Microtubule plus-end tracking proteins and their roles in cell division.
abstract: Microtubules are cellular components that are required for a variety of essential processes such as cell motility, mitosis, and intracellular transport. This is possible because of the inherent dynamic properties of microtubules. Many of these properties are tightly regulated by a number of microtubule plus-end-binding proteins or +TIPs. These proteins recognize the distal end of microtubules and are thus in the right context to control microtubule dynamics. In this review, we address how microtubule dynamics are regulated by different +TIP families, focusing on how functionally diverse +TIPs spatially and temporally regulate microtubule dynamics during animal cell division.
authors: Chromosome Instability & Dynamics Laboratory, Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal; Cell Division Unit, Department of Experimental Biology, University of Porto, Porto, Portugal.
authors: Jorge G
authors: JG
authors: Ferreira
authors: Chromosome Instability & Dynamics Laboratory, Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal.
authors: Ana L
authors: AL
authors: Pereira
authors: Chromosome Instability & Dynamics Laboratory, Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal; Cell Division Unit, Department of Experimental Biology, University of Porto, Porto, Portugal. Electronic address: maiato@ibmc.up.pt.
authors: Helder
authors: H
authors: Maiato
mesh_terms: D000818:Animals; D001692:Biological Transport; D002455:Cell Division; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis
chemical_list: D008869:Microtubule-Associated Proteins
keywords: +TIPs; Cytokinesis; Microtubule; Mitosis; Mitotic spindle