title: Global registration of ultrasound to MRI using the LC2 metric for enabling neurosurgical guidance.
abstract: Automatic and robust registration of pre-operative magnetic resonance imaging (MRI) and intra-operative ultrasound (US) is essential to neurosurgery. We reformulate and extend an approach which uses a Linear Correlation of Linear Combination (LC2)-based similarity metric, yielding a novel algorithm which allows for fully automatic US-MRI registration in the matter of seconds. It is invariant with respect to the unknown and locally varying relationship between US image intensities and both MRI intensity and its gradient. The overall method based on this both recovers global rigid alignment, as well as the parameters of a free-form-deformation (FFD) model. The algorithm is evaluated on 14 clinical neurosurgical cases with tumors, with an average landmark-based error of 2.52 mm for the rigid transformation. In addition, we systematically study the accuracy, precision, and capture range of the algorithm, as well as its sensitivity to different choices of parameters.
authors: ImFusion GmbH, München, Germany.
authors: Wolfgang
authors: W
authors: Wein
authors: ImFusion GmbH, München, Germany.
authors: Alexander
authors: A
authors: Ladikos
authors: Computer Aided Medical Procedures, Technische Universität Miinchen, Germany.
authors: Bernhard
authors: B
authors: Fuerst
authors: Computer Aided Medical Procedures, Technische Universität Miinchen, Germany.
authors: Amit
authors: A
authors: Shah
authors: Computer Aided Medical Procedures, Technische Universität Miinchen, Germany.
authors: Kanishka
authors: K
authors: Sharma
authors: Computer Aided Medical Procedures, Technische Universität Miinchen, Germany.
authors: Nassir
authors: N
authors: Navab
mesh_terms: D000465:Algorithms; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D004453:Echoencephalography / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019635:Neurosurgical Procedures / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*