title: Association of IL-17F gene polymorphisms with renal transplantation outcome.
abstract: OBJECTIVE
  Although interleukin 17 (IL-17) has some roles in renal transplantation, the influence of IL-17 gene single-nucleotide polymorphisms (SNPs) on renal transplantation has not been studied.
  
  
  METHODS
  The associations of 5 IL-17F gene SNPs (-1507G/A, 6329G/A, 7384A/G, 7470G/A, and 7489A/G) with renal transplantation outcome were analyzed. Polymerase chain reaction with sequence-specific primers (for -1507G/A and 6329G/A) and direct sequencing (for 7384A/G, 7470G/A, and 7489A/G) were performed on 282 renal transplantation recipients and 210 healthy controls.
  
  
  RESULTS
  IL-17F SNPs were not associated with acute rejection. Recipients with G allele on 7489A/G showed lower graft survival than recipients without G allele (P = .04). In multivariate analysis, G allele on 7489A/G was an independent risk factor for graft failure (odds ratio = 2.77, P = .03).
  
  
  CONCLUSIONS
  IL-17F gene SNP 7489A/G was associated with renal graft failure. Further studies are needed in larger number of patients.
authors: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: H
authors: H
authors: Park
authors: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: S
authors: S
authors: Shin
authors: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: M H
authors: MH
authors: Park
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: Y S
authors: YS
authors: Kim
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors: C
authors: C
authors: Ahn
authors: Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
authors: J
authors: J
authors: Ha
authors: Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea. Electronic address: eysong1@snu.ac.kr.
authors: E Y
authors: EY
authors: Song
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006084:Graft Rejection; D006085:Graft Survival; D006650:Histocompatibility Testing; D006801:Humans; D007249:Inflammation; D020381:Interleukin-17 / Q000235:genetics*; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D056910:Republic of Korea; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D020381:Interleukin-17