title: Management of plastic bronchitis with nebulized tissue plasminogen activator: another brick in the wall.
abstract: Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in a patient with primary ciliary dyskinesia and recurrent cast formation. Further investigation into new therapeutic strategies for this devastating disease is advocated.
authors: Massimo
authors: M
authors: Colaneri
authors: Andrea
authors: A
authors: Quarti
authors: Marco
authors: M
authors: Pozzi
authors: Stefano
authors: S
authors: Gasparini
authors: Ines
authors: I
authors: Carloni
authors: Department of Mother and Child Health, Salesi Children's Hospital, Azienda Ospedaliero-Universitaria Ospedali Riuniti, Ancona, Italy. debenedictis@ospedaliriuniti.marche.it.
authors: Fernando Maria
authors: FM
authors: de Benedictis
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D001991:Bronchitis / Q000175:diagnosis / Q000188:drug therapy*; D001999:Bronchoscopy; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009330:Nebulizers and Vaporizers; D020545:Respiratory Mucosa / Q000648:ultrastructure; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D010959:Tissue Plasminogen Activator