title: Different contribution of extent of myocardial injury to left ventricular systolic and diastolic function in early reperfused acute myocardial infarction.
abstract: BACKGROUND
  We sought to investigate the influence of the extent of myocardial injury on left ventricular (LV) systolic and diastolic function in patients after reperfused acute myocardial infarction (AMI).
  
  
  METHODS
  Thirty-eight reperfused AMI patients underwent cardiac magnetic resonance (CMR) imaging after percutaneous coronary revascularization. The extent of myocardial edema and scarring were assessed by T2 weighted imaging and late gadolinium enhancement (LGE) imaging, respectively. Within a day of CMR, echocardiography was done. Using 2D speckle tracking analysis, LV longitudinal, circumferential strain, and twist were measured.
  
  
  RESULTS
  Extent of LGE were significantly correlated with LV systolic functional indices such as ejection fraction (r = -0.57, p < 0.001), regional wall motion score index (r = 0.52, p = 0.001), and global longitudinal strain (r = 0.56, p < 0.001). The diastolic functional indices significantly correlated with age (r = -0.64, p < 0.001), LV twist (r = -0.39, p = 0.02), average non-infarcted myocardial circumferential strain (r = -0.52, p = 0.001), and LV end-diastolic wall stress index (r = -0.47, p = 0.003 with e') but not or weakly with extent of LGE. In multivariate analysis, age and non-infarcted myocardial circumferential strain independently correlated with diastolic functional indices rather than extent of injury.
  
  
  CONCLUSIONS
  In patients with timely reperfused AMI, not only extent of myocardial injury but also age and non-infarcted myocardial function were more significantly related to LV chamber diastolic function.
authors: Hyemoon
authors: H
authors: Chung
authors: Ji-Hyun
authors: JH
authors: Yoon
authors: Young Won
authors: YW
authors: Yoon
authors: Chul Hwan
authors: CH
authors: Park
authors: Eun Jung
authors: EJ
authors: Ko
authors: Jong Youn
authors: JY
authors: Kim
authors: Pil-Ki
authors: PK
authors: Min
authors: Tae Hoon
authors: TH
authors: Kim
authors: Byoung Kwon
authors: BK
authors: Lee
authors: Bum-Kee
authors: BK
authors: Hong
authors: Se-Joong
authors: SJ
authors: Rim
authors: Hyuck Moon
authors: HM
authors: Kwon
authors: Division of Cardiology, Heart Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. choi0928@yuhs.ac.
authors: Eui-Young
authors: EY
authors: Choi
mesh_terms: D054459:Elasticity Imaging Techniques / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017682:Myocardial Stunning / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*