title: Effects of statins on incident dementia in patients with type 2 DM: a population-based retrospective cohort study in Taiwan.
abstract: BACKGROUND
  Patients with Type 2 diabetes (T2DM) are prone to develop dementia. Results from a recent study indicated that statin users had lower chance of developing incident dementia. However there is little information on the potential benefits of statin use on dementia in patients with T2DM cohort.
  
  
  METHODS
  A population-based retrospective study using a nationwide cohort of National Health Insurance Research Database in Taiwan was performed. T2DM cohort with regular use of statins was followed up to 8 years. Multivariate cox-proportional hazards regression model was used to estimate the association between statin use and incidence of dementia including Alzheimer's disease and non-Alzheimer dementia after adjusting for several potential confounders.
  
  
  RESULTS
  Among 28,321 patients diagnosed with T2DM age above 50 and without history of dementia before 2000/1/1, 15,770 patients who had never used statin and 2,400 patients who regularly used statin drugs were enrolled. After adjusting for age group, gender, CCI (Charlson-Deyo comorbidity index) group, stroke types and anti-diabetic drugs, regular statin use was associated with a decreased risk of developing incident Alzheimer's disease dementia (adjusted HR: 0.48, 95% CI 0.30 - 0.76, p<0.001), but not in non-Alzheimer dementia (adjusted HR: 1.07, 95% CI 0.54-2.12 p = 0.844) in patients with T2DM. Further analysis showed significant protective effects of the use of atorvastatin and simvastatin.
  
  
  CONCLUSIONS
  Regular use of statins might decrease the risk of developing Alzheimer's disease in patients with T2DM while no benefit was observed in non-Alzheimer dementia. Among statins, both atorvastatin and simvastatin showed significant benefits.
authors: Department of Endocrinology and Metabolism, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan ; Department of Biomedical Informatics, Asia University, Taichung, Taiwan ; Department of Gerontechnology and Service Management, Nan Kai University of Technology, Nantou, Taiwan.
authors: Jui-Ming
authors: JM
authors: Chen
authors: Department of Information Management, Hsing Wu University, New Taipei City, Taiwan.
authors: Cheng-Wei
authors: CW
authors: Chang
authors: Graduate Institute of Biomedical Informatics, Taipei Medical University, Taipei, Taiwan.
authors: Tzu-Hao
authors: TH
authors: Chang
authors: Department of Computer Science and Information Engineering, National Central University, Chungli, Taiwan.
authors: Chi-Chang
authors: CC
authors: Hsu
authors: Department of Gerontechnology and Service Management, Nan Kai University of Technology, Nantou, Taiwan ; Department of Computer Science and Information Engineering, National Central University, Chungli, Taiwan.
authors: Jorng-Tzong
authors: JT
authors: Horng
authors: Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan ; School of Medicine, National Defense Medical Center, Taipei, Taiwan ; School of Medicine, National Yang-Ming University, Taipei, Taiwan ; Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan.
authors: Wayne H-H
authors: WH
authors: Sheu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000188:drug therapy; D003704:Dementia / Q000150:complications* / Q000188:drug therapy*; D003710:Demography; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors