title: Salting-out thin-layer chromatography and computational analysis of some oral hypoglycemic drugs.
abstract: A quantitative structure-retention relationship study of some oral hypoglycemic drugs was carried out using a salting-out thin-layer chromatographic technique. Aqueous solution of ammonium sulfate and acetonitrile was used as a mobile phase. It was established that the applied mobile phase has different effects on retention of the studied oral antidiabetic drugs. The factors that affect the salting-out process were determined. In this study a good correlation between the structures of the investigated drugs with the retention data and molecular descriptors was established throughout computational analysis and using molecular operating environment software, focusing on octanol/water partition coefficient, molar refractivity, total hydrophobic surface area, hydrophobic volume, Van der Waals energy and solvation energy. Quantitative structure-retention relationship modeling for the separation of the investigated drugs was carried out, validated and evaluated.
authors: Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt.
authors: Abdel Maaboud Ismail
authors: AM
authors: Mohamed
authors: Fardous Abdel-Fattah
authors: FA
authors: Mohamed
authors: Sameh Abdel-Raouf
authors: SA
authors: Ahmed
authors: Ahmed Safwat
authors: AS
authors: Aboraia
authors: Yahya Abduh Salim
authors: YA
authors: Mohamed
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D000645:Ammonium Sulfate / Q000737:chemistry; D002855:Chromatography, Thin Layer / Q000379:methods*; D062126:Databases, Chemical; D057927:Hydrophobic and Hydrophilic Interactions; D007004:Hypoglycemic Agents / Q000032:analysis* / Q000737:chemistry*; D000442:Octanols / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D000097:Acetonitriles; D007004:Hypoglycemic Agents; D000442:Octanols; D014867:Water; D000645:Ammonium Sulfate; C032159:acetonitrile
keywords: computational analysis; molecular operating environment; oral hypoglycemic drugs; quantitative structure-retention relationship; salting-out TLC