title: Preferential deposition of visceral adipose tissue occurs due to physical inactivity.
abstract: We hypothesised that strict inactivity (bed rest) would lead to regional differences in fat deposition. Twenty-four male subjects underwent 60 d bed rest and remained inactive (n = 9), performed resistance exercise plus whole-body vibration (RVE; n = 7) or resistance exercise only (RE; n = 8). Fat mass was assessed via dual X-ray absorptiometry. In the inactive subjects, fat deposition differed between body regions (P = 0.0005) with android region visceral adipose tissue increasing the most (+29% at the end of bed rest), followed by remainder of the trunk (from chin to the iliac crest; +10%) and the arms and legs (both +7%). Insulin sensitivity reduced in the inactive subjects at the end of bed rest (P = 0.036). RE did not have a significant impact on regional fat mass changes (P ⩾ 0.055). In RVE, increases in visceral adipose tissue (-14%; P = 0.028 vs inactive subjects) and in the arms (arms -8%, P = 0.011 vs inactive) were not seen. We conclude that inactivity leads to a preferential increase in visceral adipose tissue.
authors: Center of Muscle and Bone Research, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors: D L
authors: 000000029307832X
authors: DL
authors: Belavý
authors: Clinic for Endocrinology, Diabetes and Nutrition, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors: M
authors: M
authors: Möhlig
authors: German Institute of Human Nutrition, Potsdam-Rehbrücke, Nuthetal, Germany.
authors: A F H
authors: AF
authors: Pfeiffer
authors: Center of Muscle and Bone Research, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors: D
authors: D
authors: Felsenberg
authors: Center of Muscle and Bone Research, Charité Universitätsmedizin Berlin, Berlin, Germany.
authors: G
authors: G
authors: Armbrecht
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D001510:Bed Rest / Q000009:adverse effects; D015444:Exercise; D018475:Head-Down Tilt / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009133:Muscular Atrophy / Q000473:pathology* / Q000517:prevention & control; D055070:Resistance Training / Q000379:methods*; D013026:Space Flight; D013997:Time Factors; D014732:Vibration; D018474:Weightlessness Simulation