title: Polymeric films loaded with vitamin E and aloe vera for topical application in the treatment of burn wounds.
abstract: Burns are serious traumas related to skin damage, causing extreme pain and possibly death. Natural drugs such as Aloe vera and vitamin E have been demonstrated to be beneficial in formulations for wound healing. The aim of this work is to develop and evaluate polymeric films containing Aloe vera and vitamin E to treat wounds caused by burns. Polymeric films containing different quantities of sodium alginate and polyvinyl alcohol (PVA) were characterized for their mechanical properties and drug release. The polymeric films, which were produced, were thin, flexible, resistant, and suitable for application on damaged skin, such as in burn wounds. Around 30% of vitamin E acetate was released from the polymeric films within 12 hours. The in vivo experiments with tape stripping indicated an effective accumulation in the stratum corneum when compared to a commercial cream containing the same quantity of vitamin E acetate. Vitamin E acetate was found in higher quantities in the deep layers of the stratum corneum when the film formulation was applied. The results obtained show that the bioadhesive films containing vitamin E acetate and Aloe vera could be an innovative therapeutic system for the treatment of burns.
authors: Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, 90610-000 Porto Alegre, RS, Brazil.
authors: Gabriela Garrastazu
authors: GG
authors: Pereira
authors: Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, 90610-000 Porto Alegre, RS, Brazil.
authors: Sílvia Stanisçuaki
authors: SS
authors: Guterres
authors: Department of Pharmacy, University of Parma, Via Università, 12, 43121 Parma, Italy.
authors: Anna Giulia
authors: AG
authors: Balducci
authors: Department of Pharmacy, University of Parma, Via Università, 12, 43121 Parma, Italy.
authors: Paolo
authors: P
authors: Colombo
authors: Graduate School of Health-Pharmacy, University of Technology Sydney, 15 Broadway, Ultimo, NSW 2007, Australia.
authors: Fabio
authors: 0000-0001-7372-1456
authors: F
authors: Sonvico
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000504:Aloe / Q000737:chemistry*; D000704:Analysis of Variance; D004817:Epidermis / Q000737:chemistry / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008422:Materials Testing; D028321:Plant Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D063465:Skin Cream; D014810:Vitamin E / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D028321:Plant Preparations; D011108:Polymers; D014810:Vitamin E