title: Effect and mechanism of salvianolic acid B on the myocardial ischemia-reperfusion injury in rats.
abstract: OBJECTIVE
  To investigate the effect of salvianolic acid B on rats with myocardial ischemia-reperfusion injury.
  
  
  METHODS
  SD rats were randomly divided into five groups (n=10 in each group): A sham operation group, B ischemic reperfusion group model group, C low dose salvianolic acid B group, D median dose salvianolic acid B group, E high dose salvianolic acid B group. One hour after establishment of the myocardial ischemia-reperfusion model, the concentration and the apoptotic index of the plasma level of myocardial enzymes (CTn I, CK-MB), SOD, MDA, NO, ET were measured. Heart tissues were obtained and micro-structural changes were observed.
  
  
  RESULTS
  Compared the model group, the plasma CTn, CK-MB, MDA and ET contents were significantly increased, NO, T-SOD contents were decreased in the treatment group (group C, D, and E) (P<0.05); compared with group E, the plasma CTn I, CK-MB, MDA and ET levels were increased, the NO, T-SOD levels were decreased in groups C and D (P<0.05). Infarct size was significantly reduced, and the myocardial ultrastructural changes were improved significantly in treatment group.
  
  
  CONCLUSIONS
  Salvianolic acid B has a significant protective effect on myocardial ischemia-reperfusion injury. It can alleviate oxidative stress, reduce calcium overload, improve endothelial function and so on.
authors: Department of Cardiovascular Medicine, Qilu Hospital, Shandong University, No 107 Wenhua Xi Road, Jinan 250012, P.R. China; Department of Cardiovascular Medicine, Third Affiliated Hospital of Liaoning Medical College, Jinzhou 121000, Liaoning Province, China.
authors: Ling
authors: L
authors: Xue
authors: Department of Cardiovascular Medicine, Third Affiliated Hospital of Liaoning Medical College, Jinzhou 121000, Liaoning Province, China.
authors: Zhen
authors: Z
authors: Wu
authors: Department of Cardiovascular Medicine, Qilu Hospital, Shandong University, No 107 Wenhua Xi Road, Jinan 250012, P.R. China. Electronic address: jxp64@163.com.
authors: Xiao-Ping
authors: XP
authors: Ji
authors: Department of Cardiovascular Medicine, Third Affiliated Hospital of Liaoning Medical College, Jinzhou 121000, Liaoning Province, China.
authors: Xia-Qing
authors: XQ
authors: Gao
authors: Department of Cardiovascular Medicine, Third Affiliated Hospital of Liaoning Medical College, Jinzhou 121000, Liaoning Province, China.
authors: Yan-Hua
authors: YH
authors: Guo
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001572:Benzofurans / Q000494:pharmacology*; D052279:Creatine Kinase, MB Form / Q000097:blood; D006321:Heart / Q000187:drug effects*; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology*; D009206:Myocardium / Q000166:cytology / Q000473:pathology; D032383:Myocytes, Cardiac / Q000187:drug effects; D009569:Nitric Oxide / Q000097:blood; D010088:Oxidoreductases / Q000097:blood; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019210:Troponin I / Q000097:blood; D053630:Depsides
chemical_list: D001572:Benzofurans; D052279:Creatine Kinase, MB Form; D009569:Nitric Oxide; D010088:Oxidoreductases; D020011:Protective Agents; D019210:Troponin I; C076944:salvianolic acid B; D053630:Depsides
keywords: Inflammatory response; Ischemia-reperfusion injury; Myocardial infarction; Salvianolic acid B