title: Variability of oxidative stress biomarkers in hemodialysis patients.
abstract: Oxidative stress biomarkers may have a role in the future to assist clinical decisions regarding the use of antioxidant therapies and their efficacy. The aims of this study were to evaluate the within and between-individual variability of plasma oxidative stress biomarkers and investigate factors affecting their variability. Plasma F2-isoprostanes and protein carbonyls were measured in 14 hemodialysis patients every 2 weeks for 10 weeks. Within-individual coefficients of variation (CVs) were isoprostanes = 30.4% (range = 6.1-66.7%) and protein carbonyls = 16.3% (8.4-29.5%). Between-individual CVs were isoprostanes = 34.4% (28.9-40.2%) and protein carbonyls = 19.5% (15.6-24.5%). There were no significant (p > 0.05) relationships between the oxidative stress biomarkers and dietary antioxidant intake, medications, clinical and demographic parameters.
authors: Renal Medicine, Royal Brisbane and Women's Hospital , Brisbane, Queensland , Australia .
authors: Rumbidzai
authors: R
authors: Dahwa
authors: Robert G
authors: RG
authors: Fassett
authors: Zaimin
authors: Z
authors: Wang
authors: David
authors: D
authors: Briskey
authors: Alistair R
authors: AR
authors: Mallard
authors: Jeff S
authors: JS
authors: Coombes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D028441:F2-Isoprostanes / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D050050:Protein Carbonylation; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000628:therapy
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D028441:F2-Isoprostanes