title: Viscoelastic guidance of resuscitation.
abstract: OBJECTIVE
  Bleeding in trauma carries a high mortality and is increased in case of coagulopathy. Our understanding of hemostasis and coagulopathy has improved, leading to a change in the protocols for hemostatic monitoring. This review describes the current state of evidence supporting the use of viscoelastic hemostatic assays to guide trauma resuscitation.
  
  
  RESULTS
  Viscoelastic hemostatic assays such as thrombelastography and rotational thrombelastometry have shown to reduce bleeding, transfusion of fresh frozen plasma and platelets, and possibly mortality in different surgical populations. In trauma care, viscoelastic hemostatic assays allows for rapid and timely identification of coagulopathy and individualized, goal-directed transfusion therapy. As part of the resuscitation concept, viscoelastic hemostatic assays seem to improve outcome also in trauma; however, there is a need for randomized clinical trials to confirm this.
  
  
  CONCLUSIONS
  We are moving toward avoiding coagulopathy by individualized, goal-directed transfusion therapy, using viscoelastic hemostatic assays to guide ongoing resuscitation of actively bleeding patients in a goal-directed manner.
authors: aDepartment of Anesthesia, Centre of Head and Orthopedics, Copenhagen University Hospital, Rigshospitalet bSection for Transfusion Medicine, Capital Region Blood Bank, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark cDivision of Acute Care Surgery, Department of Surgery, Centre for Translational Injury Research (CeTIR), University of Texas Medical School at Houston, Houston, Texas, USA.
authors: Jakob
authors: J
authors: Stensballe
authors: Sisse R
authors: SR
authors: Ostrowski
authors: Pär I
authors: PI
authors: Johansson
mesh_terms: D001803:Blood Transfusion; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D012151:Resuscitation; D013916:Thrombelastography; D014148:Tranexamic Acid / Q000627:therapeutic use; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D014148:Tranexamic Acid