title: A fatality involving AH-7921.
abstract: A case is presented of a 19-year-old white male who was found dead in bed by a friend. While no anatomic cause of death was observed at autopsy, toxicological analysis of his blood identified AH-7921, a synthetic opioid. AH-7921 was isolated by liquid-liquid extraction into n-butyl chloride from alkalinized samples. Extracts were analyzed and quantified by gas chromatography mass spectrometry in selected ion monitoring mode. The heart blood had an AH-7921 concentration of 3.9 mg/L and the peripheral blood concentration was 9.1 mg/L. In addition to the blood, all submitted postmortem specimens including urine, liver, kidney, spleen, heart, lung, brain, bile and stomach content were quantified. The following concentrations of AH-7921 were reported: 6.0 mg/L in urine, 26 mg/kg in liver, 7.2 mg/kg in kidney, 8.0 mg/kg in spleen, 5.1 mg/kg in heart, 21 mg/kg in lung, 7.7 mg/kg in brain, 17 mg/L in bile and 120 mg/125 mL in the stomach content. The medical examiner reported that the cause of death was opioid intoxication and the manner of death was accident.
authors: Division of Forensic Toxicology, Armed Forces Medical Examiner System, Dover AFB, Dover, DE 19902, USA.
authors: Shawn P
authors: SP
authors: Vorce
authors: Jessica L
authors: JL
authors: Knittel
authors: Justin M
authors: JM
authors: Holler
authors: Joseph
authors: J
authors: Magluilo
authors: Barry
authors: B
authors: Levine
authors: Philip
authors: P
authors: Berran
authors: Thomas Z
authors: TZ
authors: Bosy
mesh_terms: D000059:Accidents; D000328:Adult; D000701:Analgesics, Opioid / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning* / Q000652:urine; D001549:Benzamides / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning* / Q000652:urine; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D059625:Liquid-Liquid Extraction; D008297:Male; D011041:Poisoning / Q000097:blood / Q000209:etiology / Q000652:urine; D011180:Postmortem Changes; D014018:Tissue Distribution; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D001549:Benzamides; C006215:AH 7921