title: Limited hepatitis B virus replication space in the chronically hepatitis C virus-infected liver.
abstract: We compared the kinetics and magnitude of hepatitis B virus (HBV) infection in hepatitis C virus (HCV)-naive and chronically HCV-infected chimpanzees in whose livers type I interferon-stimulated gene (ISG) expression is strongly induced. HBV infection was delayed and attenuated in the HCV-infected animals, and the number of HBV-infected hepatocytes was drastically reduced. These results suggest that establishment of HBV infection and its replication space is limited by the antiviral effects of type I interferon in the chronically HCV-infected liver.
authors: Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA.
authors: S F
authors: SF
authors: Wieland
authors: S
authors: S
authors: Asabe
authors: R E
authors: RE
authors: Engle
authors: R H
authors: RH
authors: Purcell
authors: F V
authors: FV
authors: Chisari
mesh_terms: D000818:Animals; D060085:Coinfection / Q000276:immunology* / Q000821:virology; D004195:Disease Models, Animal; D016174:Hepacivirus / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D006509:Hepatitis B / Q000821:virology*; D006515:Hepatitis B virus / Q000254:growth & development / Q000276:immunology / Q000502:physiology*; D019698:Hepatitis C, Chronic / Q000276:immunology*; D022781:Hepatocytes / Q000821:virology; D007370:Interferon Type I / Q000096:biosynthesis / Q000276:immunology*; D008099:Liver / Q000821:virology; D002679:Pan troglodytes; D014779:Virus Replication
chemical_list: D007370:Interferon Type I