title: Anaplastic large cell lymphoma involving anterior segment of the eye.
abstract: A 36-year-old woman was diagnosed with anaplastic large cell lymphoma (ALCL) by excisional biopsy of a left frontal skin lesion. During the first cycle of chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisolone), the patient complained of right ocular pain and inflammation. Cytologic examination using aqueous humor revealed atypical lymphocytes, suggesting intraocular ALCL involvement. Acute angle closure developed in the anterior chamber due to rapid progression of ALCL, causing pupillary block. Laser and surgical interventions were attempted but failed to relieve the pupillary block. Finally, radiation therapy resolved the pupillary block to restore the anterior chamber and normalize intraocular pressure. This is the first case in the English literature of ALCL involving the iris to cause acute secondary angle closure.
authors: Department of Ophthalmology, Dongguk University Seoul, Graduate School of Medicine, Seoul, Korea.
authors: Choul Yong
authors: CY
authors: Park
authors: Department of Ophthalmology, Dongguk University Seoul, Graduate School of Medicine, Seoul, Korea.
authors: Sang Won
authors: SW
authors: Hwang
authors: Department of Internal Medicine, Dongguk University Seoul, Graduate School of Medicine, Seoul, Korea.
authors: Do Yeun
authors: DY
authors: Kim
authors: Department of Laboratory Medicine, Dongguk University Seoul, Graduate School of Medicine, Seoul, Korea.
authors: Hee Jin
authors: HJ
authors: Huh
authors: Department of Ophthalmology, Dongguk University Seoul, Graduate School of Medicine, Seoul, Korea.
authors: Jong-Hyun
authors: JH
authors: Oh
mesh_terms: D000328:Adult; D000869:Anterior Eye Segment / Q000473:pathology*; D001706:Biopsy; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness; D049268:Positron-Emission Tomography
keywords: Acute angle closure; Anaplastic large cell lymphoma; Eye; Radiotherapy