title: Iron-catalyzed vinylogous aldol condensation of Biginelli products and its application toward pyrido[4,3-d]pyrimidinones.
abstract: A novel iron-catalyzed vinylogous aldol condensation of Biginelli products with aryl aldehydes has been developed for the syntheses of potential bioactive (E)-6-arylvinyl-dihydropyrimidin-2(1H)-ones. These materials are valuable synthetic precursors to drug-like pyrido[4,3-d]pyrimidine derivatives. The amide group at the 5-position of the dihydropyrimidin-2(1H)-ones played an important role in the vinylogous aldol condensation reaction.
authors: Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University , Xinxiang, Henan 453007, PR China.
authors: Lianqiang
authors: L
authors: Zhang
authors: Zhiguo
authors: Z
authors: Zhang
authors: Qingfeng
authors: Q
authors: Liu
authors: Tongxin
authors: T
authors: Liu
authors: Guisheng
authors: G
authors: Zhang
mesh_terms: D002384:Catalysis; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D011743:Pyrimidines; D011744:Pyrimidinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011743:Pyrimidines; D011744:Pyrimidinones; C000592524:pyrido(4,3-d)pyrimidine; D007501:Iron