title: Twin Pregnancy Obtention of Patient with Nonmosaic Klinefelter's Syndrome and His Wife with Chromosome 9 Inversion by ICSI Treatment.
abstract: A 24-year-old man was diagnosed with klinefelter's syndrome (KS) and his wife was found to have an inversion on chromosome 9-46, XX, inv (9) (p11q21)- because of infertility. Intracytoplasmic sperm injection (ICSI) was performed for fertilization after fluorescence in-situ hybridization (FISH) was used to analyze the aneuploidy rate of the X and Y chromosomes of the ejaculated sperms of the patient, and 99 sperms were haploid among 100 sperms that were to be analyzed. A twin pregnancy was achieved. The chromosomes of the two fetuses were identified as 46, XY and 46, XY, inv (9)(p11q21) after a prenatal diagnosis at 18 weeks gestation. Two healthy twins were born through caesarean section at 32 weeks gestation because of premature rupture of membranes (PROM).
authors: The Reproductive Research Center, Renmin Hospital, Hubei university of Medicine, Shiyan, China.
authors: Changjun
authors: C
authors: Zhang
authors: The Reproductive Research Center, Renmin Hospital, Hubei university of Medicine, Shiyan, China.
authors: Haiying
authors: H
authors: Peng
authors: The Reproductive Research Center, Renmin Hospital, Hubei university of Medicine, Shiyan, China.
authors: Yueyue
authors: Y
authors: Hu
keywords: Chromosome Inversion; FISH; ICSI; Infertility; Klinefelter’s Syndrome