title: Extracts of Cistanche deserticola Can Antagonize Immunosenescence and Extend Life Span in Senescence-Accelerated Mouse Prone 8 (SAM-P8) Mice.
abstract: The senescence accelerated mouse prone 8 substrain (SAM-P8), widely accepted as an animal model for studying aging and antiaging drugs, was used to examine the effects of dietary supplementation with extracts of Cistanche deserticola (ECD) which has been used extensively in traditional Chinese medicine because of its perceived ability to promote immune function in the elderly. Eight-month-old male SAM-P8 mice were treated with ECD by daily oral administrations for 4 weeks. The results showed that dietary supplementation of 150 mg/kg and 450 mg/kg of ECD could extend the life span measured by Kaplan-Meier survival analysis in dose-dependent manner. Dietary supplementation of SAM-P8 mice for 4 weeks with 100, 500, and 2500 mg/kg of ECD was shown to result in significant increases in both naive T and natural killer cells in blood and spleen cell populations. In contrast, peripheral memory T cells and proinflammatory cytokine, IL-6 in serum, were substantially decreased in the mice that ingested 100 and 500 mg/kg of ECD daily. Additionally, Sca-1 positive cells, the recognized progenitors of peripheral naive T cells, were restored in parallel. Our results provide clear experimental support for long standing clinical observational studies showing that Cistanche deserticola possesses significant effects in extending life span and suggest this is achieved by antagonizing immunosenescence.
authors: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
authors: Ke
authors: K
authors: Zhang
authors: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
authors: Xu
authors: X
authors: Ma
authors: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
authors: Wenjun
authors: W
authors: He
authors: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
authors: Haixia
authors: H
authors: Li
authors: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
authors: Shuyan
authors: S
authors: Han
authors: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
authors: Yong
authors: Y
authors: Jiang
authors: Medical and Healthy Analytical Center, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
authors: Hounan
authors: H
authors: Wu
authors: Fundamental Research Faculty, Fancl Research Institute, FANCL Corporation, 12-13 Kamishinano, Totsuka-ku, Yokohama, Kanagawa 244-0806, Japan.
authors: Li
authors: L
authors: Han
authors: Fundamental Research Faculty, Fancl Research Institute, FANCL Corporation, 12-13 Kamishinano, Totsuka-ku, Yokohama, Kanagawa 244-0806, Japan.
authors: Tomohiro
authors: 0000-0001-7538-3032
authors: T
authors: Ohno
authors: Fundamental Research Faculty, Fancl Research Institute, FANCL Corporation, 12-13 Kamishinano, Totsuka-ku, Yokohama, Kanagawa 244-0806, Japan.
authors: Nobuo
authors: N
authors: Uotsu
authors: Fundamental Research Faculty, Fancl Research Institute, FANCL Corporation, 12-13 Kamishinano, Totsuka-ku, Yokohama, Kanagawa 244-0806, Japan.
authors: Kohji
authors: K
authors: Yamaguchi
authors: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China ; Department of Integration of Traditional Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
authors: Zhizhong
authors: Z
authors: Ma
authors: Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China.
authors: Pengfei
authors: P
authors: Tu