title: The relationship of serum uric acid with non-alcoholic fatty liver disease.
abstract: OBJECTIVE
  Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological entity which is characterized by the presence of fat droplets in hepatocytes without alcohol consumption, representing a spectrum of hepatic injuries, ranging from simple steatosis (SS) to non-alcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. In recent years, experimental and observational studies suggest a role for serum uric acid (SUA) in NAFLD. However, there are few reports investigating SUA in histologically proven NAFLD. The aim of the present study was to evaluate the relationship of SUA with liver histology in non-diabetic patients with NAFLD.
  
  
  METHODS
  A total of 242 male patients with NAFLD (102 with NASH and 140 with SS) were included. Histopathological evaluation was carried out according to Kleiner's scoring scale. Hyperuricemia was diagnosed as SUA of more than 7 mg/dL.
  
  
  RESULTS
  The prevalence of hyperuricemia was 33.4%. SUA levels in patients with NASH were significantly higher than those of SS (p=0.035). Univariate and multivariate analyses both demonstrated that hyperuricemia had a significant association with younger age [OR (95%CI), 0.930 (0.884-0.979), p=0.005], higher body mass index [OR (95%CI), 1.173 (1.059-1.301), p=0.002] and hepatocellular ballooning [OR (95%CI), 1.678 (1.041-2.702), p=0.033].
  
  
  CONCLUSIONS
  Hyperuricemia is a common finding in patients with NAFLD and is independently associated with early histological findings in this clinically relevant condition. Further longitudinal studies are needed to characterize the role of SUA in the natural history of NAFLD.
authors: Ankara Mevki Military Hospital, Anittepe Dispensary, Biochemistry Laboratory, Ankara, Turkey. Electronic address: erdimsertoglu@gmail.com.
authors: Erdim
authors: E
authors: Sertoglu
authors: Gulhane School of Medicine, Department of Gastroenterology, Ankara, Turkey.
authors: Cemal Nuri
authors: CN
authors: Ercin
authors: Gulhane School of Medicine, Department of Gastroenterology, Ankara, Turkey.
authors: Gurkan
authors: G
authors: Celebi
authors: Gulhane School of Medicine, Department of Gastroenterology, Ankara, Turkey.
authors: Hasan
authors: H
authors: Gurel
authors: Adana Military Hospital, Department of Medical Biochemistry, Adana, Turkey.
authors: Huseyin
authors: H
authors: Kayadibi
authors: Izmir Military Hospital, Department of Gastroenterology, Izmir, Turkey.
authors: Halil
authors: H
authors: Genc
authors: Etimesgut Military Hospital, Department of Gastroenterology, Ankara, Turkey.
authors: Muammer
authors: M
authors: Kara
authors: Gulhane School of Medicine, Department of Gastroenterology, Ankara, Turkey.
authors: Teoman
authors: T
authors: Dogru
mesh_terms: D000328:Adult; D000886:Anthropometry; D006801:Humans; D033461:Hyperuricemia / Q000097:blood; D008297:Male; D015999:Multivariate Analysis; D065626:Non-alcoholic Fatty Liver Disease / Q000097:blood* / Q000473:pathology; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Uric acid