title: RACK1 and the microRNA pathway: is it déjà-vu all over again?
abstract: MicroRNAs (miRNAs) control many aspects of development and adaption in plants and in animals by post-transcriptional control of mRNA stability and translatability. Over the last years numerous proteins have been identified in the miRNA pathway. The versatile scaffold protein RACK1 has been associated with efficient miRNA production and function in plants and metazoans. Here, we briefly summarize the differences of RACK1 function in the plant and animal miRNA pathways and discuss putative mechanisms and functional roles of RACK1 in miRNA biogenesis and action.
authors: Center for Plant Molecular Biology (ZMBP); University of Tübingen; Tübingen, Germany; Chemical Genomics Centre (CGC) of the Max Planck Society; Dortmund, Germany, & MPI for Developmental Biology; Tübingen, Germany.
authors: Corinna
authors: C
authors: Speth
authors: Center for Plant Molecular Biology (ZMBP); University of Tübingen; Tübingen, Germany; Chemical Genomics Centre (CGC) of the Max Planck Society; Dortmund, Germany, & MPI for Developmental Biology; Tübingen, Germany.
authors: Sascha
authors: S
authors: Laubinger
mesh_terms: D000818:Animals; D035683:MicroRNAs / Q000096:biosynthesis / Q000378:metabolism*; D008954:Models, Biological; D010944:Plants / Q000378:metabolism*; D000075370:Receptors for Activated C Kinase; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D035683:MicroRNAs; D000075370:Receptors for Activated C Kinase; D011956:Receptors, Cell Surface
keywords: ARGONAUTE; Arabidopsis; DICER; RACK1; SERRATE; microRNA