title: Innate resistance against Toxoplasma gondii: an evolutionary tale of mice, cats, and men.
abstract: Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of these findings for the T. gondii host-pathogen relationship and for human disease are discussed.
authors: Immunopathology Laboratory, René Rachou Institute, Oswaldo Cruz Foundation-Minas Gerais, 30190-002, Belo Horizonte, MG, Brazil; Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605-02324, USA. Electronic address: ritoga@cpqrr.fiocruz.br.
authors: Ricardo T
authors: RT
authors: Gazzinelli
authors: Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil.
authors: Rondon
authors: R
authors: Mendonça-Neto
authors: Institute for Genetics, University of Cologne, 50674 Cologne, Germany.
authors: Jingtao
authors: J
authors: Lilue
authors: Institute for Genetics, University of Cologne, 50674 Cologne, Germany; Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6, 2780-156 Oeiras, Portugal. Electronic address: jhoward@igc.gulbenkian.pt.
authors: Jonathan
authors: J
authors: Howard
authors: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: asher@niaid.nih.gov.
authors: Alan
authors: A
authors: Sher
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002415:Cats; D006801:Humans; D007113:Immunity, Innate; D051379:Mice; D011971:Receptors, Immunologic / Q000276:immunology* / Q000378:metabolism; D014122:Toxoplasma / Q000276:immunology*; D014123:Toxoplasmosis / Q000276:immunology* / Q000469:parasitology; D014124:Toxoplasmosis, Animal / Q000276:immunology* / Q000469:parasitology
chemical_list: D011971:Receptors, Immunologic