title: Histidine rich glycoprotein and cancer: a multi-faceted relationship.
abstract: A better understanding of the interplay between the tumor environment, the immune system, and hemostatic apparatus is essential to effectively improve cancer treatment. Histidine-rich glycoprotein (HRG) is an abundant plasma protein with a wide array of functions. HRG has the ability to bind multiple ligands thereby modulating immunity, cell adhesion, angiogenesis, and thrombosis. Many of these functions are involved in tumor progression and antitumor response. We outline current data on HRG as an important potential player and as a potential future target for cancer therapy.
authors: 2410 Lee Ave. Victoria, BC Cancer Agency, Vancouver Island Centre, BC, Canada V8R 6V5. rami.kotb@bccancer.bc.ca.
authors: Lisa D S
authors: LD
authors: Johnson
authors: Hadi A
authors: HA
authors: Goubran
authors: Rami R
authors: RR
authors: Kotb
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000097:blood*; D011506:Proteins / Q000378:metabolism*; D000099053:Histidine-Rich Glycoprotein
chemical_list: D001798:Blood Proteins; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein
keywords: Histidine-rich glycoprotein; hemostasis; innate immunity; macrophage; review; tumor microenvironment