title: Preclinical Models of Wound Healing: Is Man the Model? Proceedings of the Wound Healing Society Symposium.
abstract: CONCLUSIONS
  A review of therapeutic effects in preclinical and clinical studies suggests that concordance between large animal (pig=78%), small laboratory animal (53%) andin vitro(57%) results with those observed in humans is only partial. Pig models of wound healing provide major advantages over other animal models. Since the vast majority of wound-healing research is done in rodents andin vitro, the low concordance rate is a significant impediment to research that will have any clinical impact.
  
  
  RESULTS
  To generate clinically relevant experimental data, hypothesis generation should begin, or at least involve human wound tissue samples. Such tissue could be used to test a predetermined hypothesis generated based on, say, murine data. Alternatively, such tissue could be analyzed using high-throughput cell biology techniques (e.g., genomics, proteomics, or metabolomics) to identify novel mechanisms involved in human wounds. Once the hypothesis has been formulated and confirmed using human samples, identification of these same mechanisms in animals represents a valid approach that could be used for more in-depth investigations and experimental manipulations not feasible with humans.
  
  
  CONCLUSIONS
  This consensus statement issued by the Wound Healing Society symposium strongly encourages all wound researchers to involve human wound tissue validation studies to make their animal and cell biology studies more translationally and clinically significant.
authors: Department of Plastic Surgery, Comprehensive Wound Center, Center for Regenerative Medicine and Cell-Based Therapies, Wexner Medical Center, The Ohio State University , Columbus, Ohio.
authors: Gayle M
authors: GM
authors: Gordillo
authors: Skin and Wound Care Division , 3M, St. Paul, Minnesota.
authors: Stephanie F
authors: SF
authors: Bernatchez
authors: Department of Biochemistry, Virginia Commonwealth University , Richmond, Virginia.
authors: Robert
authors: R
authors: Diegelmann
authors: College of Dentistry, University of Illinois , Chicago, Illinois.
authors: Luisa A
authors: LA
authors: Di Pietro
authors: Department of Plastic Surgery, Brigham and Women's Hospital, Harvard University , Boston, Massachusetts.
authors: Elof
authors: E
authors: Eriksson
authors: Faculty of Dentistry, University of Toronto , Toronto, Canada .
authors: Boris
authors: B
authors: Hinz
authors: Department of Anesthesiology, University of Utah Health Sciences , Salt Lake City, Utah.
authors: Harriet W
authors: HW
authors: Hopf
authors: Department of Dermatology, University of Miami , Coral Gables, Florida.
authors: Robert
authors: R
authors: Kirsner
authors: Department of Plastic Surgery, Rhode Island Hospital, Brown University , Providence, Rhode Island.
authors: Paul
authors: P
authors: Liu
authors: Precision Consulting , Missouri City, Texas.
authors: Laura K S
authors: LK
authors: Parnell
authors: Department of Pathology and Laboratory Medicine, Indiana University , Indianapolis, Indiana.
authors: George E
authors: GE
authors: Sandusky
authors: Department of Surgery, Comprehensive Wound Center, Center for Regenerative Medicine and Cell-Based Therapies, Wexner Medical Center, The Ohio State University , Columbus, Ohio.
authors: Chandan K
authors: CK
authors: Sen
authors: Department of Dermatology, University of Miami , Coral Gables, Florida.
authors: Marjana
authors: M
authors: Tomic-Canic
authors: Department of Small Animal Surgery, School of Veterinary Medicine, University of Pennsylvania , Philadelphia, Pennsylvania.
authors: Susan W
authors: SW
authors: Volk
authors: La Jolla Institute for Molecular Medicine , San Diego, California. ; Department of Surgery, University of California , San Diego, California.
authors: Andrew
authors: A
authors: Baird