title: [Value of combined detection of urinary Livin and Survivin mRNA expression in the early diagnosis of bladder cancer].
abstract: OBJECTIVE
  To evaluate the value of urine Livin and Survivin mRNA expression in the early diagnosis of bladder cancer.
  
  
  METHODS
  Fifty-two cases of early bladder cancer and 30 cases of non-urinary system tumors were selected for the combined detection of urinary Livin and Survivin and urine cytology.
  
  
  RESULTS
  Livin and Survivin in urine and urinary cytology sensitivity were 71.2% (37/52) , 67.3% (35/52), 23.1% (12/52); Specificity were 96.7% (29/30) , 93.3% (28/30) and 96.7% (29/30) respectively. Urine Survivin sensitivity, specificity compared with Livin were no significant difference (all P > 0.05). Urinary Livin and Survivin were more sensitive than urine cytology, and the differences were statistically significant(all P < 0.05).
  
  
  CONCLUSIONS
  The combined urinary detection of Livin, Survivin mRNA expression is a noninvasive early diagnosis of bladder cancer with sensitivity and specificity.
authors: Department of Urology, Fourth Affiliated Hospital, Nanchang University, Nanchang 330002, China.
authors: Long-lai
authors: LL
authors: Jiang
authors: Department of Urology, Fourth Affiliated Hospital, Nanchang University, Nanchang 330002, China. Email: 914002489@qq.com.
authors: Mei-mao
authors: MM
authors: Xie
authors: Department of Urology, Fourth Affiliated Hospital, Nanchang University, Nanchang 330002, China.
authors: Xiao-rong
authors: XR
authors: Wang
authors: Department of Urology, Fourth Affiliated Hospital, Nanchang University, Nanchang 330002, China.
authors: Yan
authors: Y
authors: Zhao
authors: Department of Urology, Fourth Affiliated Hospital, Nanchang University, Nanchang 330002, China.
authors: Zhong-jun
authors: ZJ
authors: Wang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000652:urine*; D000328:Adult; D000368:Aged; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000652:urine*; D012333:RNA, Messenger; D012680:Sensitivity and Specificity; D000077022:Survivin; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis* / Q000652:urine
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C107489:BIRC5 protein, human; C419866:BIRC7 protein, human; D051034:Inhibitor of Apoptosis Proteins; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D000077022:Survivin