title: [Detection of methyl carbamate and ethyl carbamate in yellow rice wine by gas chromatography-mass spectrometry].
abstract: OBJECTIVE
  To establish the method of simultaneous determination of methylcarbamate (MC) and ethylcarbamate (EC) in yellow rice wine by gas chromatography-mass spectrometry (GC/MS).
  
  
  METHODS
  MC and EC in yellow rice wine were derived by 9-xanthydrol, and then the derivants were detected by GC/MS; and quantitatively analyzed by D5-EC isotope internal standard method.
  
  
  RESULTS
  The linearity of MC and EC ranged from 2.0 µg/L to 400.0 µg/L, with correlation coefficients at 0.998 and 0.999, respectively. The limits of quantitation (LOQ) and detection (LOD) were 0.67 and 2.0 µg/kg. When MC and EC were added in yellow rice wine at the range of 2.0-300.0 µg/kg, the intraday average recovery rate was 78.8%-102.3%, relative standard deviation was 3.2%-11.6%; interday average recovery rate was 75.4%-101.3%, relative standard deviation was 3.8%-13.4%. 20 samples of yellow rice wine from supermarket were detected using this method, the contents of MC were in the range of ND (no detected) to 1.2 µg/kg, the detection rate was 6% (3/20), the contents of EC in the range of 18.6 µg/kg to 432.3 µg/kg, with the average level at 135.2 µg/kg.
  
  
  CONCLUSIONS
  The method is simple, rapid and useful for simultaneous determination of MC and EC in yellow rice wine.
authors: Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. Email: pgwu@cdc.zj.cn.
authors: Ping-gu
authors: PG
authors: Wu
authors: Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
authors: Bing-jie
authors: BJ
authors: Ma
authors: Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
authors: Li-yuan
authors: LY
authors: Wang
authors: Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
authors: Xiang-hong
authors: XH
authors: Shen
authors: Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
authors: Jing
authors: J
authors: Zhang
authors: Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
authors: Ying
authors: Y
authors: Tan
authors: Department of Food Inspection, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China.
authors: Wei
authors: W
authors: Jiang
mesh_terms: D002219:Carbamates / Q000032:analysis*; D005506:Food Contamination / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D012275:Oryza; D014520:Urethane / Q000032:analysis*; D014920:Wine / Q000032:analysis*
chemical_list: D002219:Carbamates; D014520:Urethane; C036868:methyl carbamate