title: Exogenous administration of spermine improves glucose utilization and decreases bodyweight in mice.
abstract: Polyamines are highly charged low molecular weight aliphatic polycations and are ubiquitously present in all living cells. In addition to their previously reported role in cell proliferation and cancer, recent studies support their role in energy homeostasis and glucose metabolism. In the present study we have evaluated a polyamine-spermine for its effect on glycemic, lipid and body weight parameters. High fat diet induced obese mice (6 week old male C57B6/J mice fed on high fat diet for 22 weeks) were dosed with spermine intraperitoneally at two different doses (5mg/kg and 10mg/kg body weight) for 4 weeks and its effect on body weight, glycemic and lipid parameters was monitored. We found that at a dose of 10mg/kg bodyweight, spermine treatment resulted in a 24% reduction in the body weight and 18% reduction in the fasting glucose compared to untreated controls. Besides, spermine treated mice exhibited improved glucose utilization associated with improved fat oxidation and loss of white adipose mass. Our study is promising in the direction of exploring the spermine and their analogs for treatment of metabolic syndrome.
authors: Connexios Life Sciences Private Limited, Bangalore, India. Electronic address: satish.s@connexios.com.
authors: Satish Kumar
authors: SK
authors: Sadasivan
authors: Connexios Life Sciences Private Limited, Bangalore, India. Electronic address: balubio.2006@gmail.com.
authors: Balamuralikrishna
authors: B
authors: Vasamsetti
authors: Connexios Life Sciences Private Limited, Bangalore, India. Electronic address: jaideep.singh@connexios.com.
authors: Jaideep
authors: J
authors: Singh
authors: Connexios Life Sciences Private Limited, Bangalore, India. Electronic address: m.v.venkataranganna@connexios.com.
authors: Venkataranganna V
authors: VV
authors: Marikunte
authors: Connexios Life Sciences Private Limited, Bangalore, India. Electronic address: anup.oommen@connexios.com.
authors: Anup Mammen
authors: AM
authors: Oommen
authors: Connexios Life Sciences Private Limited, Bangalore, India. Electronic address: m.r.jagannath@connexios.com.
authors: M R
authors: MR
authors: Jagannath
authors: Connexios Life Sciences Private Limited, Bangalore, India. Electronic address: raghavendra.rao@connexios.com.
authors: Raghavendra
authors: R
authors: Pralhada Rao
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011897:Random Allocation; D013096:Spermine / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D013096:Spermine
keywords: Body weight; Diabetes; Metabolic disorder; Obesity; Polyamines; Spermine