title: Neutralizing antibody responses to foot-and-mouth disease quadrivalent (type O, A, C and Asia 1) vaccines in growing calves with pre-existing maternal antibodies.
abstract: The presence of maternal antibodies is a major obstacle for eliciting protective immune responses to foot-and-mouth disease (FMD) vaccines in young, growing animals. In this report, we analyzed the ability of inactivated quadrivalent oil emulsified and aluminium hydroxide adjuvanted FMD vaccines to elicit neutralizing antibody responses in growing calves that had maternal antibodies. Our results demonstrate that oil emulsified vaccines but not aluminium hydroxide adjuvanted FMD vaccines could surmount maternal antibodies to elicit strong and significant levels of neutralizing antibody responses in growing claves.
authors: Indian Veterinary Research Institute, Hebbal, Bangalore 560 024, India. Electronic address: pkpatilvet@yahoo.com.
authors: Prasanna K
authors: PK
authors: Patil
authors: University of Agricultural Sciences, Dharwad 580 005, India.
authors: Channabasavaraj M
authors: CM
authors: Sajjanar
authors: Indian Veterinary Research Institute, Hebbal, Bangalore 560 024, India.
authors: Chitattor
authors: C
authors: Natarajan
authors: Institut National de la Santé et de la Recherche Médicale, Unité 1138, Paris F-75006, France. Electronic address: jagadeesh.bayry@crc.jussieu.fr.
authors: Jagadeesh
authors: J
authors: Bayry
mesh_terms: D000276:Adjuvants, Immunologic; D000536:Aluminum Hydroxide / Q000276:immunology; D000818:Animals; D057134:Antibodies, Neutralizing / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology; D001208:Asia; D002417:Cattle; D005536:Foot-and-Mouth Disease / Q000276:immunology* / Q000517:prevention & control; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D009821:Oils / Q000378:metabolism; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D009821:Oils; D015164:Vaccines, Inactivated; D014765:Viral Vaccines; D000536:Aluminum Hydroxide
keywords: Calves; Foot-and-mouth disease; Foot-and-mouth disease virus; Maternal antibodies; Oil adjuvant; Virus neutralization