title: Subjective cognitive decline predicts future deterioration in cognitively normal patients with Parkinson's disease.
abstract: Increasing evidence suggests that subjective cognitive decline (SCD) is a potential predictor of future cognitive decline or dementia. We investigated whether SCD in patients with Parkinson's disease (PD) is a predictor of future cognitive decline. Forty-six cognitively normal patients with PD were selected using comprehensive neuropsychological tests, and classified depending on the presence (PD-SCD(+), n = 25) or absence of SCD (PD-SCD(-), n = 21). After a mean follow-up of 2.4 years, we repeated the cognitive assessments with the same subjects. The clinical characteristics and cognitive performance of the 2 groups did not differ at baseline. At the follow-up assessment, 11 patients in the PD-SCD(+) group (44.0%) and 2 in the PD-SCD(-) group (9.5%) were diagnosed with mild cognitive impairment (MCI), and the PD-SCD(+) patients showed more rapid decline in semantic fluency and visuospatial memory tasks than those in the PD-SCD(-) group. A multivariate logistic regression analysis showed that presence of SCD (odds ratio, 8.378; 95% confidential interval, 1.472-47.683, p = 0.017) and higher Unified PD Rating Scale motor score of 20 or more (odds ratio, 4.539; 95% confidential interval, 1.004-20.528; p = 0.049) were risk factors for incident MCI. Present results demonstrate that SCD in cognitively normal patients with PD is an independent risk factor for incident MCI and acts as a predictor for future cognitive decline.
authors: Department of Neurology, Yonsei University Wonju College of Medicine, Wonju, Korea; Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Jin Yong
authors: JY
authors: Hong
authors: Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Mun Kyung
authors: MK
authors: Sunwoo
authors: Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Seok Jong
authors: SJ
authors: Chung
authors: Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Jee Hyun
authors: JH
authors: Ham
authors: Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Ji E
authors: JE
authors: Lee
authors: Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
authors: Young H
authors: YH
authors: Sohn
authors: Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address: phisland@chol.net.
authors: Phil Hyu
authors: PH
authors: Lee
mesh_terms: D000368:Aged; D003071:Cognition; D060825:Cognitive Dysfunction / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000523:psychology*; D011237:Predictive Value of Tests; D012307:Risk Factors
keywords: Mild cognitive impairment; Parkinson's disease; Semantic fluency; Subjective cognitive decline; Visuospatial memory