title: Soluble TNF receptors and kidney dysfunction in the elderly.
abstract: The importance of TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in the development of kidney disease is being unraveled. Yet, community-based data regarding the role of sTNFRs are lacking. We assessed serum sTNFRs and aspects of kidney damage cross-sectionally in two independent community-based cohorts of elderly participants: Prospective Investigation of the Vasculature in Uppsala Seniors (n=815; mean age, 75 years; 51% women) and Uppsala Longitudinal Study of Adult Men (n=778; mean age, 78 years). Serum sTNFR1 correlated substantially with different aspects of kidney pathology in the Uppsala Longitudinal Study of Adult Men cohort (R=-0.52 for estimated GFR, R=0.22 for urinary albumin-to-creatinine ratio, and R=0.17 for urinary kidney injury molecule-1; P<0.001 for all), with similar correlations in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort. These associations remained significant after adjustment for age, sex, inflammatory markers, and cardiovascular risk factors and were also evident in participants without diabetes. Serum sTNFR2 was associated with all three markers in the Prospective Investigation of the Vasculature in Uppsala Seniors cohort (P<0.001 for all). Our findings from two independent community-based cohorts confirm and extend results of previous studies supporting circulating sTNFRs as relevant biomarkers for kidney damage and dysfunction in elderly individuals, even in the absence of diabetes.
authors: Centre for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; axelcefam@hotmail.com johan.arnlov@medsci.uu.se.
authors: Axel C
authors: AC
authors: Carlsson
authors: Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden;
authors: Tobias E
authors: TE
authors: Larsson
authors: Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden; and.
authors: Johanna
authors: J
authors: Helmersson-Karlqvist
authors: Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden; and.
authors: Anders
authors: A
authors: Larsson
authors: Department of Medical Sciences, Uppsala University Hospital, Uppsala, Sweden; and.
authors: Lars
authors: L
authors: Lind
authors: Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; School of Health and Social Studies, Dalarna University, Falun, Sweden axelcefam@hotmail.com johan.arnlov@medsci.uu.se.
authors: Johan
authors: J
authors: Ärnlöv
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000097:blood* / Q000453:epidemiology*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D015995:Prevalence; D011446:Prospective Studies; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood*; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000453:epidemiology*; D012307:Risk Factors; D012995:Solubility
chemical_list: D015415:Biomarkers; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II
keywords: albuminuria; chronic inflammation; chronic kidney disease; clinical nephrology; epidemiology and outcomes