title: Decreased fetal pre-adipocyte factor-1 in pregnancies complicated by gestational diabetes mellitus.
abstract: BACKGROUND
  Serum pre-adipocyte factor-1 (pref-1) is an inhibitor of adipocyte differentiation that increases in small for gestational age fetuses. It plays a role in adipose metabolism and is associated with an increased risk of metabolic diseases in adulthood. We hypothesized that preadipocyte factor-1 (pref-1) concentration is altered in fetuses born to women with gestational diabetes mellitus (GDM).
  
  
  METHODS
  Umbilical cord blood pref-1 concentrations were determined by enzyme-linked immunosorbant assay in 37 fetuses from pregnancies complicated by GDM and 45 fetuses from normal pregnancies.
  
  
  RESULTS
  Serum pref-1 concentrations were significantly lower in fetuses of women with GDM compared to normal pregnancies (16.12±6.48 vs. 22.09±7.22 μg/l, P=0.001). Birth weight was significantly higher in GDM fetuses compared to normal pregnancies (3567±544 vs. 3253±370 g, P=0.003).
  
  
  CONCLUSIONS
  Pregnancies complicated by GDM have decreased fetal pref-1 concentrations compared to normal pregnancies. These differences may be significant in terms of their later development of metabolic conditions.
authors: Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education, China.
authors: Jie
authors: J
authors: Li
authors: Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education, China.
authors: Qiuyuan
authors: Q
authors: Zhu
authors: Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education, China.
authors: Hanzhi
authors: H
authors: Wang
authors: Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education, China.
authors: Cong
authors: C
authors: Han
authors: Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education, China.
authors: Qunyan
authors: Q
authors: Zhou
authors: Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education, China.
authors: Hefeng
authors: H
authors: Huang
authors: Women's Hospital, School of Medicine, Zhejiang University, Key Laboratory of Reproductive Genetics, Ministry of Education, China. Electronic address: mydong.cn@hotmail.com.
authors: Minyue
authors: M
authors: Dong
mesh_terms: D000328:Adult; D000375:Aging; D001724:Birth Weight; D002135:Calcium-Binding Proteins; D003430:Cross-Sectional Studies; D016640:Diabetes, Gestational / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins
keywords: Fetus; Gestational diabetes; Metabolic diseases; Preadipocyte factor-1