title: Reservoir targeted vaccine against Borrelia burgdorferi: a new strategy to prevent Lyme disease transmission.
abstract: A high prevalence of infection with Borrelia burgdorferi in ixodid ticks is correlated with a high incidence of Lyme disease. The transmission of B. burgdorferi to humans can be disrupted by targeting 2 key elements in its enzootic cycle: the reservoir host and the tick vector. In a prospective 5-year field trial, we show that oral vaccination of wild white-footed mice resulted in outer surface protein A-specific seropositivity that led to reductions of 23% and 76% in the nymphal infection prevalence in a cumulative, time-dependent manner (2 and 5 years, respectively), whereas the proportion of infected ticks recovered from control plots varied randomly over time. Significant decreases in tick infection prevalence were observed within 3 years of vaccine deployment. Implementation of such a long-term public health measure could substantially reduce the risk of human exposure to Lyme disease.
authors: University of Tennessee Health Sciences Center Biopeptides, Memphis, Tennessee.
authors: Luciana Meirelles
authors: LM
authors: Richer
authors: University of Pennsylvania, Philadelphia.
authors: Dustin
authors: D
authors: Brisson
authors: University of Tennessee Health Sciences Center.
authors: Rita
authors: R
authors: Melo
authors: Cary Institute of Ecosystem Studies, Millbrook, New York.
authors: Richard S
authors: RS
authors: Ostfeld
authors: Division of High Consequence Pathogens and Pathology, One Health Office, Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Dhaka, Bangladesh.
authors: Nordin
authors: N
authors: Zeidner
authors: University of Tennessee Health Sciences Center Biopeptides, Memphis, Tennessee.
authors: Maria
authors: M
authors: Gomes-Solecki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology; D025065:Borrelia burgdorferi / Q000276:immunology*; D004197:Disease Reservoirs / Q000382:microbiology / Q000662:veterinary; D008074:Lipoproteins / Q000276:immunology; D008193:Lyme Disease / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission*; D022123:Lyme Disease Vaccines / Q000276:immunology*; D051379:Mice; D010542:Peromyscus / Q000276:immunology / Q000382:microbiology; D013987:Ticks / Q000276:immunology / Q000382:microbiology; D014611:Vaccination / Q000379:methods*
chemical_list: D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D008074:Lipoproteins; D022123:Lyme Disease Vaccines; C072045:OspA protein
keywords: Borrelia burgdorferi; Lyme disease; Oral vaccine; enzootic cycle; transmission; wildlife reservoir