title: Reproducibility of disc and macula optical coherence tomography using the Canon OCT-HS100 as compared with the Zeiss Cirrus HD-OCT.
abstract: OBJECTIVE
  In a clinical setting, the usefulness of optical coherence tomography (OCT) is strongly dependent on reproducibility of the measurement. The aim of the present study was to evaluate macula and optic disc measurement reproducibility with the new spectral-domain OCT (SD-OCT) from Canon (Canon OCT-HS100) and to compare reproducibility and obtained measurements with the Zeiss Cirrus HD-OCT.
  
  
  METHODS
  Macula and optic disc parameters from the right eyes of 31 subjects were obtained twice with both instruments. Interoperator reproducibility was evaluated by use of the coefficient of repeatability (CR), and the obtained measurements were compared between the instruments.
  
  
  RESULTS
  No difference in interoperator reproducibility could be found when comparing the 2 instruments and reproducibility ranged from 3.94% to 12.77% for optic disc parameters and from 1.19% to 3.54% for macula parameters. The lowest reproducibility was found for cup volume and vertical cup/disc ratio with both instruments. For all macula and retinal nerve fiber layer (RNFL) thickness measurements, there was a statistical difference when comparing the 2 instruments, except for RFNL measurements of the superior quadrant, with the Canon OCT-HS100 always evaluating the thickness to be thicker; however, the 2 instruments correlated well.
  
  
  CONCLUSIONS
  The Canon OCT-HS100 is a reproducible instrument that matches the Zeiss Cirrus HD-OCT well. It remains to be evaluated how sensitive the Canon OCT-HS100 is to detect small subtle changes in optic disc parameters and macular nerve fiber layer thickness. Furthermore, due to the differences in thickness estimation, it is important to emphasize that SD-OCTs are not interchangeable.
authors: Unit of Optometry, Department of Clinical Neuroscience, St. Erik's Eye Hospital, Karolinska Institutet, Stockholm - Sweden.
authors: Rune
authors: R
authors: Brautaset
authors: Ulrika
authors: U
authors: Birkeldh
authors: Rebecka
authors: R
authors: Rosén
authors: Marika Wahlberg
authors: MW
authors: Ramsay
authors: Maria
authors: M
authors: Nilsson
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers; D009898:Optic Disk / Q000033:anatomy & histology*; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000166:cytology; D041623:Tomography, Optical Coherence / Q000295:instrumentation*; D055815:Young Adult