title: Surgical excision of pure flat epithelial atypia identified on core needle breast biopsy.
abstract: The biology of flat epithelial atypia (FEA) is still being investigated as its presence becomes more frequent on biopsy specimens. FEA is more commonly associated with malignancy when found in association with ADH, ALH or LCIS. Pure FEA is only upgraded to cancer in 3.2% of patients. Surgical excision of pure FEA found on core needle biopsy results in overtreatment in the vast majority of breast patients and may not be necessary.
authors: University of South Florida, Department of Surgery, Tampa, FL 33606, USA.
authors: Vanessa L
authors: VL
authors: Prowler
authors: Hoffberger Breast Center, Mercy Medical Center, Baltimore, MD, USA.
authors: Jennifer E
authors: JE
authors: Joh
authors: Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
authors: Geza
authors: G
authors: Acs
authors: Department of Women's Oncology, Comprehensive Breast Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; University of South Florida, Department of Surgery, Tampa, FL 33606, USA.
authors: John V
authors: JV
authors: Kiluk
authors: Department of Women's Oncology, Comprehensive Breast Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; University of South Florida, Department of Surgery, Tampa, FL 33606, USA.
authors: Christine
authors: C
authors: Laronga
authors: Department of Women's Oncology, Comprehensive Breast Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; University of South Florida, Department of Surgery, Tampa, FL 33606, USA.
authors: Nazanin
authors: N
authors: Khakpour
authors: Department of Women's Oncology, Comprehensive Breast Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA; University of South Florida, Department of Surgery, Tampa, FL 33606, USA. Electronic address: M.Catherine.Lee@moffitt.org.
authors: M Catherine
authors: MC
authors: Lee
mesh_terms: D000328:Adult; D000368:Aged; D062005:Biopsy, Large-Core Needle; D001940:Breast / Q000473:pathology* / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology*; D002278:Carcinoma in Situ / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology*; D018275:Carcinoma, Lobular / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D060787:Neoplasm Grading
keywords: Atypical ductal hyperplasia; Atypical lobular hyperplasia; Core needle biopsy; Flat epithelial atypia