title: [Research on the relationship between combined detection of RF and CCP and Chinese medical syndrome patterns of RA].
abstract: OBJECTIVE
  To study the objective diagnostic mechanisms on Chinese medical (CM) syndrome patterns of rheumatoid arthritis (RA), and to research different titers of rheumatoid factor (RF)/citrullinated protein antibody (CCP) in CM syndrome patterns of RA.
  
  
  METHODS
  Totally 230 early RA patients were assigned to five CM syndrome pattern groups, i.e., the dampness-heat blockage group (50 cases), the cold-dampness blockage group (50 cases), the Shen-qi deficiency-cold group (50 cases), the Gan-Shen yin deficiency group (40 cases), and the blood stasis blockage group (40 cases). Another 100 healthy subjects were recruited as the healthy control group. RF-IGM, RF-IGA, RF-IGG, and anti-CCP antibody were detected and compared.
  
  
  RESULTS
  The titers of RF-IGM, RF-IGA, RF-IGG, and anti-CCP antibody were higher in all groups than in the healthy control groups (P < 0.01). As for the 5 groups, RF-IGM, RF-IGA,RF-IGG, and anti-CCP antibody were higher in the RA active stage than in the nonactive stage. They were higher in the dampness-heat blockage group in the RA active stage than in the Shen-qi deficiency-cold group, the Gan-shen yin deficiency group, and the blood stasis blockage group.
  
  
  CONCLUSIONS
  Titers of RF-IGM, RF-IGA, RF-IGG, and anti-CCP antibody could be taken as judging indicators for differentiating objective lab indices of CM syndromes and assessing the active stage of RA.
authors: Department of Clinical Laboratory, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai 200052, China. liyun-chun06@163.com
authors: Yun-Chun
authors: YC
authors: Li
authors: Department of Clinical Laboratory, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai 200052, China.
authors: Rong
authors: R
authors: Xu
authors: Department of Clinical Laboratory, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai 200052, China.
authors: Zhong-Jun
authors: ZJ
authors: Fang
authors: Department of Clinical Laboratory, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai 200052, China.
authors: Yun-Feng
authors: YF
authors: Wang
authors: Department of Clinical Laboratory, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai 200052, China.
authors: Yue
authors: Y
authors: Wang
authors: Department of Clinical Laboratory, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai 200052, China.
authors: Fan
authors: F
authors: Yang
authors: Department of Clinical Laboratory, Shanghai Guanghua Hospital of Integrative Medicine, Shanghai 200052, China.
authors: Xiao-Yun
authors: XY
authors: Ji
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D012217:Rheumatoid Factor / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor