title: Assessing the percent of necrosis after neoadjuvant chemotherapy with 24hr infusional cisplatin/3 days Doxorubicin intermittent with Ifosfamide-Doxorubicin for osteosarcoma.
abstract: BACKGROUND
  Osteosarcoma is the most common primary bone tumor in children and young adults and appropriate chemotherapy can increase limb sparing and overall survival. Yet, the toxicity of chemotherapy regimens including MTX can be life threatening. Therefore; we tried another chemotherapy regimen for these patients.
  
  
  METHODS
  We investigated 15 patients aged 15 to 40 years old and used continuous infusion of cisplatin, doxorubicin intermittently with ifosfamide, doxorubicin as neoadjuvant chemotherapy. Percent of necrosis and toxicities was recorded for each patient.
  
  
  RESULTS
  Out of 15 patients investigated, 13 were males and 2 females. Tumor necrosis≥ 90% (defined as good necrosis) was observed in 60% of patients. 26.7% of the patients showed leucopenia grade three or four, 26.7% had anemia grade three or four, and 20% showed thrombocytopenia grade three or four.
  
  
  CONCLUSIONS
  The above chemotherapy regimen can cause as good necrosis as the chemotherapy regimens including high dose of MTX with reduced toxicity and less nursing cares and laboratory tests. Of course small sample size limits extension of our result to all patients but trying this regimen is recommended in more patients to see more reliable results.
authors: Assistant Professor, Minimally Invasive Surgery Research Center, Iran University Of Medical Science, Tehran, Iran.
authors: Mozhgan Aalam
authors: MA
authors: Samimi
authors: Medical Doctor, East Sage Research Corporation, Isfahan Science and Technology Town, Isfahan, Iran.
authors: Nooshin
authors: N
authors: Mirkheshti
authors: Assistant Professor, Minimally Invasive Surgery Research Center, Iran University Of Medical Science, Tehran, Iran.
authors: Abdolreza
authors: A
authors: Pazouki
keywords: Necrosis; Neoadjuvant chemotherapy; Osteosarcoma