title: A versatile and highly efficient method for 1-chlorination of terminal and trialkylsilyl-protected alkynes.
abstract: A highly efficient one-pot procedure for the preparation of 1-chloroalkynes and 1-chlorobutadiynes from terminal and trialkylsilyl-protected precursors is reported. This convenient reaction, proceeding under mild conditions, utilizes N-chlorosuccinimide as the chlorinating agent and tolerates a range of functional groups.
authors: Department of Chemistry, University of Wrocław, 14 F. Joliot-Curie, 50-383 Wrocław (Poland).
authors: Nurbey
authors: N
authors: Gulia
authors: Bartłomiej
authors: B
authors: Pigulski
authors: Marta
authors: M
authors: Charewicz
authors: Sławomir
authors: S
authors: Szafert
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D002713:Chlorine / Q000737:chemistry*; D054879:Halogenation; D015394:Molecular Structure; D013388:Succinimides / Q000138:chemical synthesis* / Q000737:chemistry; D014297:Trimethylsilyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D013388:Succinimides; D014297:Trimethylsilyl Compounds; C015752:N-chlorosuccinimide; D002713:Chlorine
keywords: 1-haloalkynes; chlorine; halogenation; silanes; synthetic methods