title: Copper- and palladium-catalyzed amidation reactions for the synthesis of substituted imidazo[4,5-c]pyridines.
abstract: Imidazo[4,5-c]pyridines were synthesized in three steps utilizing a palladium-catalyzed amidation/cyclization strategy. N-Aryl substrates were synthesized using copper-catalyzed amidation of 3-amino-N-Boc-4-chloropyridine. Complementary protocols for the selective chlorination of imidazo[4,5-c]pyridines at the C2 and C7 positions were also developed.
authors: Department of Chemistry, 1-014 Center for Science and Technology, Syracuse University , Syracuse, New York 13244, United States.
authors: Robert J
authors: RJ
authors: Wilson
authors: Adam J
authors: AJ
authors: Rosenberg
authors: Lauren
authors: L
authors: Kaminsky
authors: Daniel A
authors: DA
authors: Clark
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C000592589:3-amino-N-Boc-4-chloropyridine; D007093:Imidazoles; D011725:Pyridines; D010165:Palladium; D003300:Copper