title: Vaccination models and optimal control strategies to dengue.
abstract: As the development of a dengue vaccine is ongoing, we simulate an hypothetical vaccine as an extra protection to the population. In a first phase, the vaccination process is studied as a new compartment in the model, and different ways of distributing the vaccines investigated: pediatric and random mass vaccines, with distinct levels of efficacy and durability. In a second step, the vaccination is seen as a control variable in the epidemiological process. In both cases, epidemic and endemic scenarios are included in order to analyze distinct outbreak realities.
authors: Helena Sofia
authors: HS
authors: Rodrigues
authors: M Teresa T
authors: MT
authors: Monteiro
authors: Delfim F M
authors: DF
authors: Torres
mesh_terms: D000330:Aedes / Q000821:virology; D000818:Animals; D050936:Basic Reproduction Number; D002648:Child; D003198:Computer Simulation; D003715:Dengue / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D053059:Dengue Vaccines / Q000008:administration & dosage / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D004196:Disease Outbreaks / Q000517:prevention & control*; D006801:Humans; D018448:Models, Immunological; D014611:Vaccination / Q000592:standards*
chemical_list: D053059:Dengue Vaccines