title: The roles of BDNF, S100B, and oxidative stress in interferon-induced depression and the effect of antidepressant treatment in patients with chronic viral hepatitis: a prospective study.
abstract: OBJECTIVE
  The aim of the study was to research the relationship between interferon (IFN) induced depression and sociodemographic characteristics, neurotrophic factors and oxidative stress.
  
  
  METHODS
  Sixty four cases, 34 with Chronic Hepatitis B (CHB) and 30 with Chronic Hepatitis C (CHC), were included in the study. The patients were assessed with Structured Clinical Interview for DSM-IV (SCID-I), Hamilton Anxiety Rating Scale (HARS) and Hamilton Depression Rating Scale (HDRS) at baseline on the 2nd and 6th weeks of treatment. S100 calcium binding protein B (S100B), brain-derived neurotrophic factor (BDNF), total antioxidant status (TAS) and total oxidative stress (TOS) levels were measured at the same visits.
  
  
  RESULTS
  In total, 20 patients were diagnosed with major depression (MD) on the sixth week. A significant relationship was found between depression developed after IFN therapy and baseline HARS scores and the type of IFN-α. When the pretreatment levels of HDRS, HARS, S100B, BDNF, TAS, and TOS were compared to those after treatment on the 2nd week, there was a significant increase in HDRS and HARS levels and a significant decrease in the levels of S100B and BDNF. No significant change was determined for TAS and TOS levels.
  
  
  CONCLUSIONS
  Our study suggests that the pathogenesis of IFN induced depression may involve neurotrophic factors.
authors: Department of Psychiatry, Research and Training Hospital, Konya, Turkey. Electronic address: iezeytinci@gmail.com.
authors: Ismet Esra
authors: IE
authors: Cicek
authors: Department of Psychiatry, University of Mevlana, Faculty of Medicine, Konya, Turkey.
authors: Erdinc
authors: E
authors: Cicek
authors: Department of Psychiatry, University of Mevlana, Faculty of Medicine, Konya, Turkey.
authors: Fatih
authors: F
authors: Kayhan
authors: Department of Psychiatry, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey.
authors: Faruk
authors: F
authors: Uguz
authors: Department of Clinical Bacteriology and Infectious Disease, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey.
authors: Ibrahim
authors: I
authors: Erayman
authors: Department of Biochemistry, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey.
authors: Sevil
authors: S
authors: Kurban
authors: Department of Biochemistry, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey.
authors: F Hümeyra
authors: FH
authors: Yerlikaya
authors: Department of Biochemistry, University of Necmettin Erbakan, Meram Faculty of Medicine, Konya, Turkey.
authors: Nazmiye
authors: N
authors: Kaya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000502:physiology*; D003863:Depression / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D003865:Major Depressive Disorder / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000523:psychology; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D007372:Interferons / Q000009:adverse effects* / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood / Q000502:physiology*; D055815:Young Adult
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D007372:Interferons
keywords: Depression; Interferon; Neurotrophic factors; Oxidative stress