title: Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration.
abstract: Associations between TCF7L2 SNP and diabetic complications and diabetes-related factors were investigated. Subjects with rs7903146 variant had significantly higher prevalence of stroke (24.1% vs. 11.1%; P=0.039) among subjects exhibiting a long disease duration (≥10 years). In conclusion, the TCF7L2 SNP variant may confer a higher risk of stroke in diabetic patients.
authors: Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea.
authors: Hyung Jin
authors: HJ
authors: Choi
authors: Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea.
authors: Dong-Hwa
authors: DH
authors: Lee
authors: Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea.
authors: Hyun Jeong
authors: HJ
authors: Jeon
authors: Department of Biochemistry, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea.
authors: Dae Soon
authors: DS
authors: Kim
authors: Department of Biochemistry, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea.
authors: Yong Hee
authors: YH
authors: Lee
authors: Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea. Electronic address: tgohkjs@chungbuk.ac.kr.
authors: Taekeun
authors: T
authors: Oh
mesh_terms: D000328:Adult; D000483:Alleles; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology / Q000235:genetics*; D013997:Time Factors; D058118:Transcription Factor 7-Like 2 Protein / Q000235:genetics*
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein
keywords: Complication; SNP; TCF7L2