title: S100B is downregulated in the nuclear proteome of schizophrenia corpus callosum.
abstract: Here we report the downregulation of S100B in the nuclear proteome of the corpus callosum from nine schizophrenia patients compared to seven mentally healthy controls. Our data have been obtained primarily by mass spectrometry and later confirmed by Western blot. This is an intriguing finding coming from a brain region which is essentially composed by white matter, considering the potential role of S100B in the control of oligodendrocyte maturation. This data reinforce the importance of oligodendrocytes in schizophrenia, shedding more light to its pathobiology.
authors: Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.
authors: Johann
authors: J
authors: Steiner
authors: Andrea
authors: A
authors: Schmitt
authors: Matthias L
authors: ML
authors: Schroeter
authors: Bernhard
authors: B
authors: Bogerts
authors: Peter
authors: P
authors: Falkai
authors: Christoph W
authors: CW
authors: Turck
authors: Daniel
authors: D
authors: Martins-de-Souza
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003337:Corpus Callosum / Q000378:metabolism*; D015536:Down-Regulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D020543:Proteome; D064568:S100 Calcium Binding Protein beta Subunit / Q000378:metabolism*; D012559:Schizophrenia / Q000473:pathology*
chemical_list: D020543:Proteome; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human