title: [Effects on the lipid profile in humans of a polyphenol-rich carob (Ceratonia siliqua L.) extract in a dairy matrix like a functional food; a pilot study].
abstract: The design of functional foods enriched in nutrients that favorably alter the lipid profile to prevent cardiovascular diseases and stimulate bowel function is of great interest. We have assayed a non-extractable-tannates-rich carob-fiber (PF-1®) in a milk matrix developed by Biosearch S.A. to discover its effects on the lipid profile and bowel function of human volunteers. A 4-week interventional study (400 mL daily consumption of this functional food, containing 20 g of PF-1®/L), was conducted: blood samples were analyzed for lipid profile, glucose, transaminases, creatinine and fat-soluble vitamins. The body-mass index and bowel function of the participants in the study were also measured. A tendency for triglyceride levels to diminish was observed in all participants (P = 0.066), and in the normal-cholesterol group in particular (P = 0.078). Another tendency to total cholesterol levels fell in the hypercholesterolemic group (P = 0.061) was also found. In the normal-cholesterol group, total cholesterol (CT), HDL-cholesterol and LDL-cholesterol levels significantly increased with the consumption of the functional food (P < 0.05). A better bowel function was also recorded by volunteers. This preliminary study highlights the possible positive influence of this functional food on the regulation of the lipid profile and bowel function in humans.
authors: Departamento de Nutrición y Bromatología. Facultad de Farmacia. Universidad de Granada. España.. rodrigo.mtnz.rdgz@gmail.com.
authors: Rodrigo
authors: R
authors: Martínez-Rodríguez
authors: Departamento de Nutrición y Bromatología. Facultad de Farmacia. Universidad de Granada. España..
authors: Miguel
authors: M
authors: Navarro-Alarcón
authors: Laboratorio de Nutrición. Biosearch SA. Granada. España..
authors: Carlos
authors: C
authors: Rodríguez-Martínez
authors: Laboratorio de Nutrición. Biosearch SA. Granada. España..
authors: Juristo
authors: J
authors: Fonollá-Joya
mesh_terms: D000328:Adult; D003611:Dairy Products; D005260:Female; D055951:Functional Food; D005685:Galactans / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008351:Mannans / Q000737:chemistry*; D010865:Pilot Projects; D010936:Plant Extracts / Q000494:pharmacology*; D053149:Plant Gums / Q000737:chemistry*; D059808:Polyphenols / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D005685:Galactans; D008055:Lipids; D008351:Mannans; D010936:Plant Extracts; D053149:Plant Gums; D059808:Polyphenols; C017471:locust bean gum