title: Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis.
abstract: Etravirine is metabolized by three cytochrome P450 enzymes that are in turn induced by rifampin. Consequently, co-administration of etravirine and rifampin is not recommended. To date, however, no clinical studies exploring the drug-drug interaction of this combination have been conducted. Here we report two cases of off-label etravirine use concurrently with antitubercular treatment, dictated by the unavailability of other treatments. Plasma drug concentrations were monitored by regular measurements. Our results appear to confirm the increased metabolism of etravirine through the induction of cytochrome P450 enzymes, but the adequacy of drug levels in all of the measurements and subsequent virological suppression suggest that this drug interaction may not be clinically relevant.
authors: Institute of Infectious Diseases, Catholic University of Sacred Heart, Rome, Italy.
authors: R
authors: R
authors: Gagliardini
authors: M
authors: M
authors: Fabbiani
authors: S
authors: S
authors: Fortuna
authors: E
authors: E
authors: Visconti
authors: P
authors: P
authors: Navarra
authors: R
authors: R
authors: Cauda
authors: M
authors: M
authors: Colafigli
authors: A
authors: A
authors: De Luca
authors: E M
authors: EM
authors: Trecarichi
authors: S
authors: S
authors: Di Giambenedetto
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D009570:Nitriles; D010949:Plasma / Q000737:chemistry; D011724:Pyridazines / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011743:Pyrimidines; D012293:Rifampin / Q000627:therapeutic use*; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy*
chemical_list: D019380:Anti-HIV Agents; D000995:Antitubercular Agents; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; C451734:etravirine; D012293:Rifampin