title: [Molecular aspects of the antiviral response against hepatitis C virus implicated in vaccines development].
abstract: Hepatitis C is a contagious liver disease caused by hepacivirus of the Flaviviridae family. It has a RNA genome, a unique highly variable molecule. It encodes ten proteins which are necessary to infect cells and multiply. Replication occurs only in hepatocytes. Because of its wide genomic variability and the absence of symptoms, it is difficult to make an early diagnosis and successful treatment. In this review we analyze the molecular mechanism by which the virus infects the hepatocytes and causes the disease. We focused the analysis on different therapies, with the possibility of improving treatment with the use of new specific vaccines. We highlight the use of new therapies based on nucleic acids, mainly DNA vectors. In the near future, once this treatment is adequately evaluated in clinical trials, and the costs are calculated, it could be a very beneficial alternative to conventional methods.
authors: Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de Buenos Aires, Buenos Aires, Argentina.
authors: María Soledad
authors: MS
authors: Llanes
authors: Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de Buenos Aires, Buenos Aires, Argentina.
authors: Natalia Soledad
authors: NS
authors: Palacios
authors: Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de Buenos Aires, Buenos Aires, Argentina.
authors: Magalí
authors: M
authors: Piccione
authors: Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de Buenos Aires, Buenos Aires, Argentina.
authors: María Guillermina
authors: MG
authors: Ruiz
authors: Departamento de Ciencias Básicas y Experimentales, Universidad Nacional del Noroeste de Buenos Aires, Buenos Aires, Argentina; Centro Regional de Estudios Genómicos, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Buenos Aires, Argentina. Electronic address: layanacar@gmail.com.
authors: Carla
authors: C
authors: Layana
mesh_terms: D000818:Animals; D018450:Disease Progression; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D016679:Genome, Viral; D005838:Genotype; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics / Q000276:immunology / Q000502:physiology; D006526:Hepatitis C / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology; D018937:Hepatitis C Antibodies / Q000276:immunology; D022781:Hepatocytes / Q000821:virology; D006801:Humans; D000071497:Immunogenicity, Vaccine; D051379:Mice; D012367:RNA, Viral / Q000235:genetics; D019444:Vaccines, DNA; D022223:Vaccines, Subunit; D014761:Viral Hepatitis Vaccines / Q000627:therapeutic use*; D014764:Viral Proteins / Q000502:physiology
chemical_list: D018937:Hepatitis C Antibodies; D012367:RNA, Viral; D019444:Vaccines, DNA; D022223:Vaccines, Subunit; D014761:Viral Hepatitis Vaccines; D014764:Viral Proteins
keywords: Hepatitis C; Tratamiento; Treatment; Vaccines; Vacunas