title: [Nalbuphine in pediatric anesthesia].
abstract: Efficient and safe pediatric perioperative pain therapy in the context of a multimodal pain therapy concept requires a slight to moderate opioid analgesic. Nalbuphine is a nearly ideal opioid for this purpose due to its unique pharmacological properties as a μ-receptor antagonist/κ-receptor agonist and a high safety profile. Nalbuphine is used clinically primarily in postoperative pain therapy administered as a bolus, continuous infusion and patient-controlled analgesia. Furthermore, it is administered in different regimens for pediatric diagnostic and interventional sedation.
authors: Universitätsklinik für Anästhesie, Allgemeine Intensivmedizin und Schmerztherapie, Klinische Abteilung für allgemeine Anästhesie und Intensivmedizin, Medizinische Universität Wien, 1090, Wien, Österreich, anette-marie.schultz@meduniwien.ac.at.
authors: A-M
authors: AM
authors: Schultz-Machata
authors: K
authors: K
authors: Becke
authors: M
authors: M
authors: Weiss
mesh_terms: D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D000771:Anesthesia, Intravenous / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D002648:Child; D016292:Procedural Sedation; D004338:Drug Combinations; D006801:Humans; D006993:Hypnotics and Sedatives; D008991:Monitoring, Physiologic; D009266:Nalbuphine / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D009294:Narcotics / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy; D011300:Preoperative Care; D017473:Receptors, Opioid, kappa / Q000187:drug effects; D017450:Receptors, Opioid, mu / Q000187:drug effects
chemical_list: D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D004338:Drug Combinations; D006993:Hypnotics and Sedatives; D009294:Narcotics; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D009266:Nalbuphine