title: Dual responsive supramolecular nanogels for intracellular drug delivery.
abstract: Supramolecular nanogels cross-linked by host-guest interaction between dextran grafted benzimidazole (Dex-g-BM) and thiol-β-cyclodextrin were designed. Their special supramolecular pH-sensitivity under acidic conditions (pH < 6, within the range of malignant cellular endosomes) and reduction sensitivity in response to biologically relevant stimuli will be of great advantage to the future of cancer chemotherapeutics.
authors: Department of Chemistry, Northeast Normal University, Changchun 130024, P. R. China. chenl686@nenu.edu.cn.
authors: Xiaofei
authors: X
authors: Chen
authors: Li
authors: L
authors: Chen
authors: Xuemei
authors: X
authors: Yao
authors: Zhe
authors: Z
authors: Zhang
authors: Chaoliang
authors: C
authors: He
authors: Jingping
authors: J
authors: Zhang
authors: Xuesi
authors: X
authors: Chen
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D000080385:Nanogels; D047392:beta-Cyclodextrins; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D004317:Doxorubicin; D011094:Polyethyleneimine; C031215:betadex