title: Comparative efficacy of two interventions to discontinue long-term benzodiazepine use: cluster randomised controlled trial in primary care.
abstract: BACKGROUND
  Benzodiazepines are extensively used in primary care, but their long-term use is associated with adverse health outcomes and dependence.
  
  
  OBJECTIVE
  To analyse the efficacy of two structured interventions in primary care to enable patients to discontinue long-term benzodiazepine use.
  
  
  METHODS
  A multicentre three-arm cluster randomised controlled trial was conducted, with randomisation at general practitioner level (trial registration ISRCTN13024375). A total of 532 patients taking benzodiazepines for at least 6 months participated. After all patients were included, general practitioners were randomly allocated (1:1:1) to usual care, a structured intervention with follow-up visits (SIF) or a structured intervention with written instructions (SIW). The primary end-point was the last month self-declared benzodiazepine discontinuation confirmed by prescription claims at 12 months.
  
  
  RESULTS
  At 12 months, 76 of 168 (45%) patients in the SIW group and 86 of 191 (45%) in the SIF group had discontinued benzodiazepine use compared with 26 of 173 (15%) in the control group. After adjusting by cluster, the relative risks for benzodiazepine discontinuation were 3.01 (95% CI 2.03-4.46, P<0.0001) in the SIW and 3.00 (95% CI 2.04-4.40, P<0.0001) in the SIF group. The most frequently reported withdrawal symptoms were insomnia, anxiety and irritability.
  
  
  CONCLUSIONS
  Both interventions led to significant reductions in long-term benzodiazepine use in patients without severe comorbidity. A structured intervention with a written individualised stepped-dose reduction is less time-consuming and as effective in primary care as a more complex intervention involving follow-up visits.
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: C
authors: C
authors: Vicens
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: F
authors: F
authors: Bejarano
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: E
authors: E
authors: Sempere
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: C
authors: C
authors: Mateu
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: F
authors: F
authors: Fiol
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: I
authors: I
authors: Socias
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: E
authors: E
authors: Aragonès
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: V
authors: V
authors: Palop
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: J L
authors: JL
authors: Beltran
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: J L
authors: JL
authors: Piñol
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: G
authors: G
authors: Lera
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: S
authors: S
authors: Folch
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: M
authors: M
authors: Mengual
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: J
authors: J
authors: Basora
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: M
authors: M
authors: Esteva
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: J
authors: J
authors: Llobera
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: M
authors: M
authors: Roca
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: M
authors: M
authors: Gili
authors: Caterina Vicens, PhD, Balearic Health Service Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Ferran Bejarano, Catalunya Health Services, Reus, DAP Tarragona-Terres del l'Ebre; Ermengol Sempere, PhD, Valencia Health Services, Paterna Health Care Centre, Paterna, Valencia; Catalina Mateu, Francisca Fiol, Balearic Health Service, Son Serra-La Vileta Health Care Centre, Palma de Mallorca; Isabel Socias, Balearic Health Service, Manacor Health Care Centre, Palma de Mallorca; Enric Aragonès, PhD, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Vicente Palop, PhD, Valencia Health Services, La Ribera Hospital, Valencia; Jose Luis Beltran, Valencia Health Services, Altabix Health Care Centre, Alicante, Valencia; Josep Lluís Piñol, PhD, Catalunya Health Services, Primary Care Research Unit, Reus-Altebrat, Tarragona; Guillem Lera, Valencia Health Services, La Ribera Hospital, Valencia; Silvia Folch, Catalunya Health Services, Constantí Health Care Centre, Tarragona; Marta Mengual, Catalunya Health Services, Falset Health Care Centre, Tarragona; Josep Basora, Catalunya Health Services, Reus Health Care Centre, Tarragona; Magdalena Esteva, PhD, Joan Llobera, PhD, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca; Miguel Roca, PhD, Margalida Gili, PhD, Balearic Islands University, University Institute of Health and Science Research, Palma de Mallorca; Alfonso Leiva, MSc, Balearic Health Service, Primary Care Research Unit of Mallorca, Palma de Mallorca, Spain.
authors: A
authors: A
authors: Leiva
mesh_terms: D000368:Aged; D001569:Benzodiazepines / Q000009:adverse effects*; D016000:Cluster Analysis; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic / Q000379:methods*; D011320:Primary Health Care / Q000379:methods*; D013030:Spain; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*; D019966:Substance-Related Disorders / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D001569:Benzodiazepines