title: Should women suffering from migraine with aura be screened for biological thrombophilia?: results from a cross-sectional French study.
abstract: BACKGROUND
  Migraine, particularly migraine with aura (MA), is associated with a higher risk for ischemic stroke (IS). A procoagulant state may predispose to IS. Whether inherited biological thrombophilia are associated with migraine risk remains controversial.
  
  
  OBJECTIVE
  To assess the risk of migraine without or with aura related to inherited biological thrombophilia adjusted for the main potential confounders.
  
  
  METHODS
  A cross-sectional study was conducted in 1456 French women aged 18 to 56years, referred for biological coagulation check-up because of personal or familial venous thrombosis history. Between April 2007 and December 2008, all women answered a self-administered questionnaire to determine whether they had headache.
  
  
  RESULTS
  There were 294 (20%) migrainous sufferers (including 71 [5%] with MA), 975 (67%) non migrainous women and 187 (13%) non migrainous headache women. Inherited thrombophilia were detected in 576 (40%) women, including 389 (40%) non migrainous women, 90 (40%) migraine without aura (MWA), 33 (46%) MA women and 64 (34%) non migrainous headache women. Factor V Leiden (FVL) i.e. F5rs6025 or Factor II G20210A (FIIL) i.e. F2rs1799963 mutation was detected in 296 (30%) non migrainous women and in 100 (34%) migrainous women of which 27 had MA. There was a significant association between MA and FVL or FIIL mutations (adjusted OR=1.76 [95% CI 1.02-3.06] p=0.04) whereas this association in MWA and in non migrainous headache women was not significant. There was no significant association between migraine and other biological thrombophilia.
  
  
  CONCLUSIONS
  FVL or FIIL mutations were more likely among patients suffering from MA. Whether biological thrombophilia screening should be systematically performed in women suffering from MA remains to be determined.
authors: Unit of Gynecological Endocrinology, Cochin Port-Royal Hospital, AP-HP, University Paris Descartes, France.
authors: L
authors: L
authors: Maitrot-Mantelet
authors: Unit of Hemostasis, Cochin Port-Royal Hospital, AP-HP, University Paris Descartes, France.
authors: M H
authors: MH
authors: Horellou
authors: Unit of Neurology, Lariboisière Hospital, AP-HP, France.
authors: H
authors: H
authors: Massiou
authors: Unit of Hemostasis, Cochin Port-Royal Hospital, AP-HP, University Paris Descartes, France.
authors: J
authors: J
authors: Conard
authors: Unit of Gynecological Endocrinology, Cochin Port-Royal Hospital, AP-HP, University Paris Descartes, France.
authors: A
authors: A
authors: Gompel
authors: Unit of Gynecological Endocrinology, Cochin Port-Royal Hospital, AP-HP, University Paris Descartes, France; Unit of Hemostasis, Cochin Port-Royal Hospital, AP-HP, University Paris Descartes, France; Centre for Research in Epidemiology and Population Health, U1018, Hormones and Cardiovascular Disease, Villejuif, France. Electronic address: genevieve.plu-bureau@cch.aphp.fr.
authors: G
authors: G
authors: Plu-Bureau
mesh_terms: D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D020325:Migraine with Aura / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology; D011795:Surveys and Questionnaires; D019851:Thrombophilia / Q000175:diagnosis / Q000453:epidemiology*; D055815:Young Adult
keywords: Biological thrombophilia; Factor II mutation; Factor V Leiden mutation; Migraine with aura; Stroke