title: Nickel-catalyzed Csp2-Csp3 bond formation by carbon-fluorine activation.
abstract: We report herein a general catalytic method for Csp(2)-Csp(3) bond formation through C-F activation. The process uses an inexpensive nickel complex with either diorganozinc or alkylzinc halide reagents, including those with β-hydrogen atoms. A variety of fluorine substitution patterns and functional groups can be readily incorporated. Sequential reactions involving different precatalysts and coupling partners permit the synthesis of densely functionalized fluorinated building blocks.
authors: WuXi AppTec (Shanghai) Co., Ltd., 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131 (China).
authors: Alex D
authors: AD
authors: Sun
authors: Kaylyn
authors: K
authors: Leung
authors: Anita D
authors: AD
authors: Restivo
authors: Nicole A
authors: NA
authors: LaBerge
authors: Harumi
authors: H
authors: Takasaki
authors: Jennifer A
authors: JA
authors: Love
mesh_terms: D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D006219:Halogens / Q000737:chemistry*; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D006219:Halogens; D005461:Fluorine; D009532:Nickel
keywords: cross-coupling; fluorine; nickel; synthetic methods; zinc