title: Insights in cullin 3/WNK4 and its relationship to blood pressure regulation and electrolyte homeostasis.
abstract: One of the most important systems for protein degradation is the ubiquitin-proteasome system (UPS). The highly specific process called ubiquitination is provided by the E3 ubiquitin ligases, which mediates degradation via the proteasome system. The ubiquitin ligases based on cullins are the type of ubiquitin ligases known so far. The complex based on cullin 3 (Cul3) requires that its target protein has a bric-a-brac/tram-track/broad-complex (BTB) domain to recognize it. Cul3 has been widely associated with Kelch-like erythroid cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1) and the cytoprotective nuclear factor erythroid 2 related factor 2 (Nrf2) pathway and the proper control of cell cycle progression. Recently, Cul3 has been linked to the development of type II pseudohypoaldosteronism (PHAII or Gordon's syndrome) due to the fact that Cul3 has the ability to bind to Kelch-like 3 protein (KLHL3) and therefore mediating the degradation of some members of the WNK kinases. In this work we focused on highlighting how Cul3 system is involved in the regulation of electrolyte homeostasis and blood pressure.
authors: Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, 04510 México, D.F., Mexico.
authors: Ana Cristina
authors: AC
authors: Andérica-Romero
authors: Facultad de Medicina, Departamento de Fisiología, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, 04510 México, D.F., Mexico.
authors: Laura
authors: L
authors: Escobar
authors: Facultad de Medicina, Departamento de Fisiología, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, 04510 México, D.F., Mexico.
authors: Teresa
authors: T
authors: Padilla-Flores
authors: Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, 04510 México, D.F., Mexico. Electronic address: pedraza@unam.mx.
authors: José
authors: J
authors: Pedraza-Chaverri
mesh_terms: D001794:Blood Pressure; D044842:Cullin Proteins / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D059748:Proteolysis; D054875:Ubiquitination; D014882:Water-Electrolyte Balance
chemical_list: C503645:CUL3 protein, human; D044842:Cullin Proteins; D017346:Protein Serine-Threonine Kinases; C433806:WNK4 protein, human; D046988:Proteasome Endopeptidase Complex
keywords: Cullin 3; Hypertension; KLHL3; Ubiquitin–proteasome system; WNK kinases