title: PSA nadir and outcome in 100 patients with pT3b prostate cancer.
abstract: OBJECTIVE
  The prostate-specific antigen (PSA) nadir and long-term outcome in patients with pT3b prostate cancer were evaluated.
  
  
  METHODS
  From July 2000 to December 2012, in 100 patients (median age=62 years) with pT3b prostate cancer following radical retropubic prostatectomy (RRP) preoperative and pathological findings predictive of PSA nadir (≤0.2 vs. >0.2 ng/ml) were retrospectively evaluated; moreover, biochemical recurrence-free survival (bRFS), cancer specific survival (CSS) and overall survival (OS) in patients who underwent watchful waiting (16 cases), adjuvant (84 cases) and salvage (10 cases) therapy were recorded.
  
  
  RESULTS
  A PSA nadir >0.2 ng/ml was correlated with node involvement, Gleason score ≥9, cT2, PSA >20 ng/ml, positive surgical margins and total cancer percentage >20%. At a median follow-up of 90 months (range=10-155 months) bRFS, OS and CSS were 92%, 96% and 80%, respectively.
  
  
  CONCLUSIONS
  Radical retropubic prostatectomy combined with adjuvant and salvage treatments demonstrated a satisfactory outcome for pT3b prostate cancer.
authors: Urology Unit, Cannizzaro Hospital, Via Messina 829, Catania, Italy. piepepe@hotmail.com.
authors: Pietro
authors: P
authors: Pepe
authors: Giuseppina
authors: G
authors: Improta
authors: Filippo
authors: F
authors: Fraggetta
authors: Carmela
authors: C
authors: Emmanuele
authors: Vittorio
authors: V
authors: Simeon
authors: Giuseppe
authors: G
authors: Dibenedetto
authors: Maurizio
authors: M
authors: Colecchia
authors: Francesco
authors: F
authors: Aragona
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D006801:Humans; D007610:Kallikreins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011300:Preoperative Care; D017430:Prostate-Specific Antigen / Q000378:metabolism*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen
keywords: Prostate cancer; pT3b PCa; pT3b PSA nadir; pT3b outcome