title: Synthesis of deuterium-labeled cyamemazine and monodesmethyl cyamemazine.
abstract: A novel approach is presented for the synthesis of cyamemazine maleate and N-desmethyl cyamemazine maleate using a 10-(amino-2-methylpropyl)phenothiazine derivative. This method was successfully applied to the synthesis of [(2) H6 ]cyamemazine maleate and N-desmethyl-[(2) H3 ]cyamemazine maleate.
authors: Department of Chemistry, KL University, Vaddeswaram, Guntur Dist, India.
authors: R Sekhar
authors: RS
authors: Bolla
authors: I V
authors: IV
authors: Kasi Viswanath
mesh_terms: D003903:Deuterium / Q000737:chemistry*; D007553:Isotope Labeling; D008298:Maleates / Q000737:chemistry; D010640:Phenothiazines / Q000138:chemical synthesis*
chemical_list: D008298:Maleates; D010640:Phenothiazines; C533907:monodesmethyl cyamemazine; C028457:cyamemazine; D003903:Deuterium
keywords: N-desmethyl-[2H3]cyamemazine maleate; [2H6]cyamemazine maleate; antipsychotic; cyamepromazine; deuterium labeled; schizophrenia