title: A systematic review and quantitative assessment of sleep-disordered breathing during pregnancy and perinatal outcomes.
abstract: OBJECTIVE
  Previous investigations have suggested a strong association between sleep-disordered breathing (SDB) during pregnancy and perinatal outcomes. However, the results of the following replication studies were not always concordant. Therefore, this meta-analysis was conducted to evaluate the more reliable estimate.
  
  
  METHODS
  A systematic literature search was performed on PubMed, Springer Link, and EMBASE to identify all eligible studies published before August 2013. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using fixed or random effects model.
  
  
  RESULTS
  A total of 24 publications met the inclusion criteria and were included in this meta-analysis. Findings demonstrated that moderate-to-severe SDB during pregnancy was associated with gestational diabetes mellitus (OR=1.78; 95% CI, 1.29 to 2.46), pregnancy-related hypertension (OR=2.38; 95% CI, 1.63 to 3.47), preeclampsia (OR=2.19; 95% CI, 1.71 to 2.80), preterm delivery (OR=1.98; 95% CI, 1.59 to 2.48), low birth weight (OR=1.75; 95% CI, 1.33 to 2.32), neonatal intensive care unit (NICU) admission (OR=2.43; 95% CI, 1.61 to 3.68), intrauterine growth restriction (OR=1.44; 95% CI, 1.22 to 1.71), and Apgar score of <7 at 1 min (OR=1.78; 95% CI, 1.10 to 2.91) based on all studies but not gestational age and birth weight.
  
  
  CONCLUSIONS
  This meta-analysis revealed that moderate-to-severe SDB during pregnancy may be associated with most of adverse perinatal outcomes. Further well-designed studies are warranted to confirm our findings.
authors: Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 MeiShan Road, Hefei, Anhui, 230032, China.
authors: Xiu-Xiu
authors: XX
authors: Ding
authors: Yi-Le
authors: YL
authors: Wu
authors: Shao-Jun
authors: SJ
authors: Xu
authors: Shi-Fen
authors: SF
authors: Zhang
authors: Xiao-Min
authors: XM
authors: Jia
authors: Ruo-Ping
authors: RP
authors: Zhu
authors: Jia-Hu
authors: JH
authors: Hao
authors: Fang-Biao
authors: FB
authors: Tao
mesh_terms: D001034:Apgar Score; D016640:Diabetes, Gestational / Q000175:diagnosis; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000175:diagnosis; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000175:diagnosis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011256:Pregnancy Outcome; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis*