title: [Functional activity of NADH-dependent reductase system in the liver microsomal fraction and Guerin's carcinoma in rats exposed to preliminary irradiation].
abstract: The activity of liver and Guerin's carcinoma microsomal NADH-dependent reductase system has been investigated in tumor-bearing rats exposed to preliminary irradiation. Preliminary irradiation of rats (before transplantation of Guerin's carcinoma) resulted in the decrease of NADH-cytochrome b5 reductase activity and contents of cytochrome b5 in the Guerin's carcinoma microsomal fraction in the logarithmic phases of oncogenesis compared with the non-irradiated tumor-bearing rats. The effect of irradiation preceding transplantation of the tumor to rats results in the increase of enzymatic activities of liver microsomal NADH-cytochrome b5 reductase in the latent and logarithmic phases of tumor growth as compared with non-irradiated tumor-bearing rats. At the same time the contents of cytochrome b5 decreases. During longer periods after irradiation the investigated parameters approached to those in the group of non-irradiated tumor-bearing animals.
authors: M M
authors: MM
authors: Marchenko
authors: O V
authors: OV
authors: Ketsa
mesh_terms: D000818:Animals; D042966:Cytochrome-B(5) Reductase / Q000378:metabolism*; D015786:Cytochromes b5 / Q000378:metabolism*; D005260:Female; D015227:Lipid Peroxidation / Q000528:radiation effects; D008099:Liver / Q000201:enzymology / Q000528:radiation effects*; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000201:enzymology* / Q000378:metabolism; D010084:Oxidation-Reduction; D011829:Radiation Dosage; D051381:Rats
chemical_list: D015786:Cytochromes b5; D042966:Cytochrome-B(5) Reductase