title: Pathogenesis and prevention of intraventricular hemorrhage.
abstract: Intraventricular hemorrhage (IVH) is a major neurologic complication of prematurity. Pathogenesis of IVH is attributed to intrinsic fragility of germinal matrix vasculature and to the fluctuation in the cerebral blood flow. Germinal matrix exhibits rapid angiogenesis orchestrating formation of immature vessels. Prenatal glucocorticoid exposure remains the most effective means of preventing IVH. Therapies targeted to enhance the stability of the germinal matrix vasculature and minimize fluctuation in the cerebral blood flow might lead to more effective strategies in preventing IVH.
authors: Department of Pediatrics, Cell Biology and Anatomy, Regional Neonatal Center, New York Medical College, Maria Fareri Children's Hospital, Westchester Medical Center, 100 Woods Road, Valhalla, NY 10595, USA. Electronic address: Pballabh@msn.com.
authors: Praveen
authors: P
authors: Ballabh
mesh_terms: D001253:Astrocytes / Q000378:metabolism; D001485:Basement Membrane / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000503:physiopathology* / Q000517:prevention & control; D002552:Cerebral Ventricles / Q000098:blood supply / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005353:Fibronectins / Q000378:metabolism; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology* / Q000517:prevention & control; D018919:Neovascularization, Physiologic / Q000502:physiology*; D020286:Pericytes / Q000378:metabolism
chemical_list: D005353:Fibronectins; D005904:Glial Fibrillary Acidic Protein; D005938:Glucocorticoids
keywords: Angiogenesis; Astrocytes; Germinal matrix hemorrhage; Glucocorticoids; Indomethacin; Intraventricular hemorrhage; Pericytes; Premature infants