title: Myeloperoxidase activity is increased in hepatopulmonary syndrome in rats.
abstract: BACKGROUND
  Hepatopulmonary syndrome is formed by a triad of liver disease, intrapulmonary vascular dilatation and changes in blood gases. Its pathogenesis is not well defined, but it is speculated that a combination of factors, such as the imbalance of endothelin receptor responses, pulmonary microvascular remodeling, and genetic predisposition, leads to bacterial translocation and intrapulmonary vascular dilatation.
  
  
  OBJECTIVE
  To evaluate the myeloperoxidase activity in hepatopulmonary syndrome in rat model.
  
  
  METHODS
  Twenty-nine rats were divided into control, sham and experimental hepatopulmonary syndrome groups. Was evaluated the myeloperoxidase activity and the experimental model used to induce hepatopulmonary syndrome was common bile duct ligation.
  
  
  RESULTS
  The myeloperoxidase activity levels were significantly increased in the common bile duct ligation group as compared with the other groups. Myeloperoxidase activity was higher in the common bile duct ligation group than control group (p<0.05) and than sham group (p<0.05).
  
  
  CONCLUSIONS
  The myeloperoxidase activity is increased in experimental hepatopulmonary syndrome in rats.
authors: Lucas Souto
authors: LS
authors: Nacif
authors: Wellington
authors: W
authors: Andraus
authors: Márcia Saldanha
authors: MS
authors: Kubrusly
authors: Nilza
authors: N
authors: Molan
authors: Eleazar
authors: E
authors: Chaib
authors: Luiz Augusto Carneiro
authors: LA
authors: D'Albuquerque
mesh_terms: D000818:Animals; D020065:Hepatopulmonary Syndrome / Q000201:enzymology*; D008297:Male; D009195:Peroxidase / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D009195:Peroxidase