title: Ground-state elevation approach to suppress side reactions in gold-sensing systems based on alkyne activation.
abstract: A novel approach to suppress the side reactions observed in the reaction-based gold-sensing systems based on the alkyne activation is disclosed. By elevating steric strain around the reaction site, the gold ion promoted ring-opening process in rhodamine-lactam probes is significantly accelerated, which also leads to suppression of those possible side reactions. As a result, the probes show very high sensitivity in addition to excellent selectivity toward gold species. Furthermore, bioimaging of gold species in live cells was demonstrated with a FRET version.
authors: Department of Chemistry and Center for Electro-Photo Behaviors in Advanced Molecular System and ‡Department of Life Science, POSTECH , San 31, Hyoja-dong, Pohang 790-784, Republic of Korea.
authors: Hyewon
authors: H
authors: Seo
authors: Mi Eun
authors: ME
authors: Jun
authors: Koteeswari
authors: K
authors: Ranganathan
authors: Kyung-Ha
authors: KH
authors: Lee
authors: Kyong-Tai
authors: KT
authors: Kim
authors: Woocherl
authors: W
authors: Lim
authors: Young Min
authors: YM
authors: Rhee
authors: Kyo Han
authors: KH
authors: Ahn
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000032:analysis / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry; D015394:Molecular Structure; D012235:Rhodamines / Q000737:chemistry
chemical_list: D000480:Alkynes; D005456:Fluorescent Dyes; D007769:Lactams; D012235:Rhodamines; D006046:Gold