title: Dinner-to-bed time and post-dinner walk: new potential independent factors in esophageal cancer development.
abstract: OBJECTIVE
  Esophageal squamous cell carcinoma (ESCC) remains a significant cause of morbidity and mortality worldwide. The aim of the study was to investigate the effects of shorter dinner-to-bed time and post-dinner walk on ESCC risk.
  
  
  METHODS
  A matched case-control study with 232 ESCC patients and 286 age- and gender-matched healthy controls enrolled was conducted. Conditional logistic regression was used to calculated odds ratio (OR) and 95 % confidence intervals (95 % CI).
  
  
  RESULTS
  The adjusted ORs of ESCC for subjects with shorter dinner-to-bed time (<3 h) were 2.84 (95 % CI 1.64-4.29), relative to those with longer dinner-to-bed time (≥4 h). While post-dinner walk was associated with a decreased ESCC risk (adjusted OR 0.64; 95 % CI 0.41-0.89). What's more, when reflux symptom was added into the multivariate models, risk estimate for shorter dinner-to-bed time still remained statistically significant (p = 0.003), and risk estimate for post-dinner walk changed slightly. In the subgroup analysis stratified by post-dinner walk, subjects with shorter dinner-to-bed time experienced similar risk (adjusted ORs 2.71 vs. 2.82).
  
  
  CONCLUSIONS
  Shorter dinner-to-bed time is a potential risk factor for ESCC and post-dinner walk is a protective factor, providing evidence for the effect of lifestyle factors on ESCC risk.
authors: Department of Radiation Oncology, Qilu Hospital, Shandong University, 107 West Wenhua Road, Jinan, 250012, People's Republic of China.
authors: Qingxu
authors: Q
authors: Song
authors: Hong
authors: H
authors: Liu
authors: Jianbo
authors: J
authors: Wang
authors: Yibin
authors: Y
authors: Jia
authors: Yuan
authors: Y
authors: Liu
authors: Nana
authors: N
authors: Wang
authors: Bingxu
authors: B
authors: Tan
authors: Shanghui
authors: S
authors: Guan
authors: Dianzheng
authors: D
authors: An
authors: Yufeng
authors: Y
authors: Cheng
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology / Q000534:rehabilitation; D004938:Esophageal Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000534:rehabilitation; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D062407:Meals; D008875:Middle Aged; D012307:Risk Factors; D016138:Walking