title: MicroRNA-based therapy in pain medicine: Current progress and future prospects.
abstract: MicroRNAs (miRNAs) are small noncoding RNA molecules of 18-25 nucleotides in length that regulate gene expression involved in fundamental cell processes. The induction and chronification of pain is associated with many expressional changes in pain-related proteins. miRNA has the potential to regulate gene and protein expression associated with the induction and chronification of pain. Thus, miRNAs might have promise in therapy and as a diagnostic and prognostic biomarker in pain medicine. The application of miRNA has been an emerging field in pain research in recent years. Many studies focusing on the regulation of miRNAs under different tissue and nociceptive stimuli have been performed in recent years. In this review, we intend to introduce the most recent research in the field of miRNA related with pain medicine such as the expression and function of miRNA in different animal pain model, the challenge of application and delivery of miRNA in vivo, the potential toxic effects of miRNA and future problems in clinical application that need to be resolved. This review focuses on the results of miRNA in animal studies and the prospect for future success.
authors: Department of Anesthesiology, E-Da Hospital, Kaohsiung, Taiwan; School of Medicine, I-Shou University, Kaohsiung, Taiwan. Electronic address: tanphphd@hotmail.com.
authors: Ping-Heng
authors: PH
authors: Tan
authors: Department of Anesthesiology, E-Da Hospital, Kaohsiung, Taiwan.
authors: Yun-Ying
authors: YY
authors: Pao
authors: Department of Anesthesiology, Mackay Memorial Hospital, Taipei, Taiwan.
authors: Jen-Kun
authors: JK
authors: Cheng
authors: Department of Anesthesiology, E-Da Hospital, Kaohsiung, Taiwan.
authors: Kuo-Chuan
authors: KC
authors: Hung
authors: Department of Anesthesiology, E-Da Hospital, Kaohsiung, Taiwan.
authors: Chien-Cheng
authors: CC
authors: Liu
mesh_terms: D000818:Animals; D020868:Gene Silencing; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000503:physiopathology; D035683:MicroRNAs / Q000009:adverse effects / Q000502:physiology* / Q000627:therapeutic use; D009437:Neuralgia / Q000235:genetics / Q000503:physiopathology; D010146:Pain / Q000188:drug therapy*; D059265:Visceral Pain / Q000235:genetics / Q000503:physiopathology
chemical_list: D035683:MicroRNAs
keywords: Inflammation; MicroRNAs; Pain; Pain: neuropathic; Visceral Pain