title: High-dose amoxicillin with clavulanate for the treatment of acute otitis media in children.
abstract: OBJECTIVE
  This study uses the acute otitis media clinical practice guideline proposed in 2004 as a reference to evaluate whether antibiotics doses that are in line with the recommendations lead to better prognosis. The study also attempts to clarify possible factors that influence the outcome.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  A total of 400 children with acute otitis media were enrolled. The dosage of amoxicillin was considered to be appropriate when in accord with clinical practice guidelines, that is, 80-90 mg/kg/day. The outcome was defined according to the description of tympanic membrane on medical records. Multivariate logistic regression was used to analyze the relationship between antibiotic dosage and prognosis after adjusting for baseline factors.
  
  
  RESULTS
  The majority of prescriptions were under dosage (89.1%) but it was not noticeably associated with outcome (P = 0.41). The correlation between under dosage and poor prognosis was significant in children below 20 kg with bilateral acute otitis media (odds ratio 1.63; 95% CI 1.02-2.59, P = 0.04).
  
  
  CONCLUSIONS
  Treating acute otitis media in children, high-dose amoxicillin with clavulanate as recommended in the clinical practice guideline was superior to conventional doses only in children under 20 kg with bilateral diseases.
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
authors: Chia-Huei
authors: CH
authors: Chu
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
authors: Mao-Che
authors: MC
authors: Wang
authors: Division of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Medicine, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11172, Taiwan ; Institute of Pharmacology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
authors: Liang-Yu
authors: LY
authors: Lin
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
authors: Tzong-Yang
authors: TY
authors: Tu
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
authors: Chii-Yuan
authors: CY
authors: Huang
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
authors: Wen-Huei
authors: WH
authors: Liao
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
authors: Ching-Yin
authors: 0000-0001-5487-2531
authors: CY
authors: Ho
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, No. 201, Section 2, Shih-Pai Road, Taipei 11217, Taiwan ; Department of Otorhinolaryngology, National Yang-Ming University School of Medicine, No. 155, Section 2, Li-Nong Street, Taipei 11217, Taiwan.
authors: An-Suey
authors: AS
authors: Shiao
mesh_terms: D000208:Acute Disease; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D019818:Clavulanic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D010033:Otitis Media / Q000188:drug therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D012621:Seasons; D016896:Treatment Outcome
chemical_list: D019818:Clavulanic Acid; D000658:Amoxicillin