title: Is it necessary to perform connective tissue disorders laboratory tests when a patient experiences the first demyelinating attack?
abstract: BACKGROUND
  It may be difficult to differentiate between the first demyelinating attack and the neurological manifestations of connective tissue diseases.
  
  
  METHODS
  A total of 79 patients with optic neuritis were compared with 79 healthy controls. Their blood samples were tested for erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), antiβ2-Glycoprotein I antibody (IgG, IgM), anticardiolipin antibody (IgM, IgG), lupus anticoagulant, anti-double strand DNA (anri-ds DNA), antinuclear antibody (ANA), anti-myeloperoxidae (p-ANCA), and anti-Proteinase 3 (C-ANCA).
  
  
  RESULTS
  In clinically isolated syndrome group β2-Glycoprotein (IgM) and lupus anti-coagulant were positive in 1.3% of patients whereas ANA was positive in 1.3% and anti-β2-Glycoprotein I (IgM) was positive in 2.5% of control group. No rheumatologic disease was found in objects with positive tests.
  
  
  CONCLUSIONS
  This study shows no specific difference between two groups.
authors: Medical School, Isfahan University of Medical Sciences, Isfahan, Iran ; Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Isfahan Eye Research Center, Feiz Hospital, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Masoud
authors: M
authors: Etemadifar
authors: Department of Rheumatology, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Alimohammad
authors: A
authors: Fatemi
authors: Medical School, Isfahan University of Medical Sciences, Isfahan, Iran ; Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Hourossadat
authors: H
authors: Hashemijazi
authors: Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors: Amir
authors: A
authors: Kazemizadeh
keywords: Clinically isolated syndrome; connective tissue disease tests; multiple sclerosis