title: Two siblings with unbalanced t(10;21) translocations and non-neuropathic neuropathic bladder.
abstract: We describe an unusual case of two siblings, aged 5 years and 5 months, with an unbalanced t(10;21) translocation and concomitant non-neuropathic neuropathic bladder abnormalities, whose father was a known balanced carrier of the translocation, t(10;21). Postnatally both siblings had normal spine and neurological examination. However, ultrasound scans and micturition cystourethrograms revealed grossly distended non-neuropathic neuropathic bladder. In both siblings, the bladder abnormalities responded to clean intermittent catheterisation. On follow-up, dimercaptosuccinic acid scans for both siblings showed equal split function with no scarring.
authors: Surgery Unit, UCL Institute of Child Health, London, UK.
authors: Mandela
authors: M
authors: Thyoka
authors: Alex
authors: A
authors: Henderson
authors: Bozena
authors: B
authors: Starzyk
authors: Anupam
authors: A
authors: Lall
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D035781:Siblings; D014178:Translocation, Genetic / Q000235:genetics*; D014463:Ultrasonography; D001743:Urinary Bladder / Q000002:abnormalities* / Q000000981:diagnostic imaging; D014546:Urinary Catheterization