title: [Folates in the treatment of depression].
abstract: Depression is an important and often recurrent illness. An initial antidepressant trial is effective at achieving remission for about 30 % of patients when prescribed as monotherapy, with the majority of patients returning as partial or non-responders. Suboptimal serum and red blood cell folate levels have been associated with a poorer response to antidepressant therapy, a greater severity of symptoms, later onset of clinical improvement, and overall treatment resistance. This article reviews the evidence for L-methylfolate and folic acid as antidepressive agents in depression and discusses their clinical use.
authors: Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Martin Gropius Krankenhaus, I. Psychiatrische Klinik, Eberswalde.
authors: S
authors: S
authors: Erbe
authors: Abteilung für Psychiatrie, Schlosspark-Klinik, Berlin.
authors: U N
authors: UN
authors: Pellert
mesh_terms: D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D061218:Depressive Disorder, Treatment-Resistant / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005492:Folic Acid / Q000378:metabolism / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged
chemical_list: D000928:Antidepressive Agents; D005492:Folic Acid; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)