title: Sinugyrosanolide A, an unprecedented C-4 norcembranoid, from the Formosan soft coral Sinularia gyrosa.
abstract: Chemical investigations on the acetone extract of the Formosan soft coral Sinularia gyrosa have obtained a novel C-4 norcembranoid possessing an unprecedented tricyclo[9.3.0.0(3,8)]tetradecane skeleton, namely sinugyrosanolide A. The NMR spectroscopic data of the novel norcembranoid were completely assigned by using a combination of 2D NMR experiments including (1)H-(1)H COSY, HSQC, HMBC, and NOESY. The cytotoxicities, anti-HCMV (human cytomegalovirus) endonuclease activities and antibacterial activities were evaluated in vitro. It showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with an EC50 of 11.8μM.
authors: Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan; Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors: Shi-Yie
authors: SY
authors: Cheng
authors: Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
authors: Neng-Lang
authors: NL
authors: Shih
authors: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors: Cheng-Ta
authors: CT
authors: Chuang
authors: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors: Shu-Fen
authors: SF
authors: Chiou
authors: Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan.
authors: Chia-Ning
authors: CN
authors: Yang
authors: Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors: Shang-Kwei
authors: SK
authors: Wang
authors: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan; Center of Asia-Pacific Marine Researches, National Sun Yat-Sen University, Kaohsiung, Taiwan. Electronic address: yihduh@mail.nsysu.edu.tw.
authors: Chang-Yih
authors: CY
authors: Duh
mesh_terms: D000473:Alkanes / Q000737:chemistry; D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002244:Carbon / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003587:Cytomegalovirus / Q000201:enzymology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004720:Endonucleases / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D014764:Viral Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000473:Alkanes; D000900:Anti-Bacterial Agents; D004224:Diterpenes; D014764:Viral Proteins; C000592787:sinugyrosanolide A; C024713:n-tetradecane; D002244:Carbon; D004720:Endonucleases
keywords: Anti-HCMV (human cytomegalovirus) endonuclease activities; Antibacterial activities; Cytotoxicities; Norcembranoid; P-388 (mouse lymphocytic leukemia); Sinularia gyrosa