title: Role of overexpression of MACC1 and/or FAK in predicting prognosis of hepatocellular carcinoma after liver transplantation.
abstract: BACKGROUND
  Metastasis-associated in colon cancer-1 (MACC1) acts as a promoter of tumor metastasis; however, the predictive value of MACC1 for hepatocellular carcinoma (HCC) after liver transplantation (LT) remains unclear.
  
  
  METHODS
  We examined the expression of MACC1 and its target genes MET and FAK by quantitative PCR in 160 patients with HCC that was undergone LT.
  
  
  RESULTS
  The patients with MACC1(high) or FAK(high) in HCCs showed a significantly shorter overall survival and higher cumulative recurrence rates after liver transplantation (LT), compared with MACC1(low) or FAK(low) group. Multivariate analysis indicated that MACC1 alone or combination of MACC1/FAK was an independent prognostic factor for overall survival and cumulative recurrence.
  
  
  CONCLUSIONS
  MACC1 or combination of MACC1/FAK could serve as a novel biomarker in predicting the prognosis of HCC after LT.
authors: 1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province.
authors: Sheng
authors: S
authors: Gao
authors: 1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province.
authors: Bing-Yi
authors: BY
authors: Lin
authors: 1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors: Zhe
authors: Z
authors: Yang
authors: 1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province.
authors: Zhi-Yun
authors: ZY
authors: Zheng
authors: 1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province.
authors: Zhi-Kun
authors: ZK
authors: Liu
authors: 1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors: Li-Ming
authors: LM
authors: Wu
authors: 1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors: Hai-Yang
authors: HY
authors: Xie
authors: 1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors: Lin
authors: L
authors: Zhou
authors: 1. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health. ; 2. Key Laboratory of Organ Transplantation, Zhejiang Province. ; 3. Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
authors: Shu-Sen
authors: SS
authors: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology; D005260:Female; D051417:Focal Adhesion Kinase 1 / Q000096:biosynthesis*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology; D016031:Liver Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000096:biosynthesis; D015534:Trans-Activators; D014157:Transcription Factors / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; C544162:MACC1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; C491743:MET protein, human; D019859:Proto-Oncogene Proteins c-met; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human
keywords: hepatocellular carcinoma; liver transplantation; metastasis; metastasis-associated in colon cancer-1; prognosis