title: Oral squamous cell carcinomas in age distinct population: a comparison of p53 immunoexpression.
abstract: OBJECTIVE
  The study aimed to assess the diffused expression of p53 protein in patients with OSCC and its association with age at diagnosis (using 50 years as a cut point).
  
  
  METHODS
  Ten normal oral mucosa and sixty OSCC lesions from age-distinct patient populations were immunohistochemically analyzed for the expression of p53 protein.
  
  
  RESULTS
  In OSCC cases, 31 out of total 60 cases (51.67%) showed positive expression for p53 protein and it was more common in older study group (56.67%) than in younger study group (46.67%) but the difference was not statistically significant. Moreover, there was also no significant difference in the p53 indices (percentage of p53 positive cells) between the two study groups (P = 0.827).
  
  
  CONCLUSIONS
  The alteration rates were found to be slightly higher in older patients although not statistically significant.
authors: Department of Oral and Maxillofacial Pathology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
authors: Akhilesh
authors: A
authors: Chandra
authors: Anil
authors: A
authors: Singh
authors: Bastian Thattil
authors: BT
authors: Sebastian
authors: Archana
authors: A
authors: Agnihotri
authors: Ruchita
authors: R
authors: Bali
authors: Pushpendra Kumar
authors: PK
authors: Verma
mesh_terms: D000367:Age Factors; D000368:Aged; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology*; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology*; D011230:Precancerous Conditions; D011379:Prognosis; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000276:immunology
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53