title: High resolution MRI anatomy of the cat brain at 3 Tesla.
abstract: BACKGROUND
  Feline models of neurologic diseases, such as lysosomal storage diseases, leukodystrophies, Parkinson's disease, stroke and NeuroAIDS, accurately recreate many aspects of human disease allowing for comparative study of neuropathology and the testing of novel therapeutics. Here we describe in vivo visualization of fine structures within the feline brain that were previously only visible post mortem.
  
  
  METHODS
  3Tesla MR images were acquired using T1-weighted (T1w) 3D magnetization-prepared rapid gradient echo (MPRAGE) sequence (0.4mm isotropic resolution) and T2-weighted (T2w) turbo spin echo (TSE) images (0.3mm×0.3mm×1mm resolution). Anatomic structures were identified based on feline and canine histology.
  
  
  RESULTS
  T2w high resolution MR images with detailed structural identification are provided in transverse, sagittal and dorsal planes. T1w MR images are provided electronically in three dimensions for unrestricted spatial evaluation.
  
  
  METHODS
  Many areas of the feline brain previously unresolvable on MRI are clearly visible in three orientations, including the dentate, interpositus and fastigial cerebellar nuclei, cranial nerves, lateral geniculate nucleus, optic radiation, cochlea, caudal colliculus, temporal lobe, precuneus, spinocerebellar tract, vestibular nuclei, reticular formation, pyramids and rostral and middle cerebral arteries. Additionally, the feline brain is represented in three dimensions for the first time.
  
  
  CONCLUSIONS
  These data establish normal appearance of detailed anatomical structures of the feline brain, which provide reference when evaluating neurologic disease or testing efficacy of novel therapeutics in animal models.
authors: Scott-Ritchey Research Center, Auburn University, Auburn, AL, United States. Electronic address: grayhea@auburn.edu.
authors: Heather L
authors: HL
authors: Gray-Edwards
authors: MR R&D Siemens Healthcare, Malvern, PA, United States.
authors: Nouha
authors: N
authors: Salibi
authors: Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, United States.
authors: Eleanor M
authors: EM
authors: Josephson
authors: Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL, United States.
authors: Judith A
authors: JA
authors: Hudson
authors: Scott-Ritchey Research Center, Auburn University, Auburn, AL, United States.
authors: Nancy R
authors: NR
authors: Cox
authors: Scott-Ritchey Research Center, Auburn University, Auburn, AL, United States.
authors: Ashley N
authors: AN
authors: Randle
authors: Scott-Ritchey Research Center, Auburn University, Auburn, AL, United States; Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, United States.
authors: Victoria J
authors: VJ
authors: McCurdy
authors: Scott-Ritchey Research Center, Auburn University, Auburn, AL, United States; Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, United States.
authors: Allison M
authors: AM
authors: Bradbury
authors: Scott-Ritchey Research Center, Auburn University, Auburn, AL, United States.
authors: Diane U
authors: DU
authors: Wilson
authors: Auburn University MRI Research Center, Auburn, AL, United States.
authors: Ronald J
authors: RJ
authors: Beyers
authors: Department of Electrical and Computer Engineering, Auburn University, Auburn, AL, United States; Auburn University MRI Research Center, Auburn, AL, United States.
authors: Thomas S
authors: TS
authors: Denney
authors: Scott-Ritchey Research Center, Auburn University, Auburn, AL, United States; Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL, United States.
authors: Douglas R
authors: DR
authors: Martin
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D002415:Cats; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male
keywords: Animal model; Brain; Cat; Central nervous system; MRI; Translational