title: The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis.
abstract: The object of this study is to observe the effects of platycodin D, a saponin purified from Platycodi Radix, on mice collagen-induced arthritis (CIA). A daily dose of 200, 100, and 50 mg/kg platycodin D was administered orally to male DBA/1J mice for 40 days after initial collagen immunization. To ascertain the effects administering the collagen booster, CIA-related features (including body weight, poly-arthritis, knee and paw thickness, and paw weight increase) was measured from histopathological changes in the spleen, left popliteal lymph node, third digit, and the knee joint regions. CIA-related bone and cartilage damage improved significantly in the platycodin D-administered CIA mice. Additionally, myeloperoxidase (MPO) levels in the paw were reduced in platycodin D-treated CIA mice compared to CIA control groups. The level of malondialdehyde (MDA), an indicator of oxidative stress, decreased in a dose-dependent manner in the platycodin D group. Finally, the production of IL-6 and TNF- α , involved in rheumatoid arthritis pathogenesis, was suppressed by treatment with platycodin D. Taken together, these results suggest that platycodin D is a promising new effective antirheumatoid arthritis agent, exerting anti-inflammatory, antioxidative and immunomodulatory effects in CIA mice.
authors: Department of Rehabilitation Medicine, College of Korean Medicine, Daegu Haany University, 1 Hannydaero, Gyeongsan, Gyeongsangbuk-Do 712-715, Republic of Korea.
authors: O Gon
authors: OG
authors: Kwon
authors: The Medical Research Center for Globalization of Herbal Medicine, College of Korean Medicine, Daegu Haany University, 1 Hannydaero, Gyeongsan, Gyeongsangbuk-Do 712-715, Republic of Korea ; Department of Histology and Anatomy, College of Korean Medicine, Daegu Haany University, 1 Hannydaero, Gyeongsan, Gyeongsangbuk-Do 712-715, Republic of Korea.
authors: Sae Kwang
authors: SK
authors: Ku
authors: Department of Rehabilitation Medicine, College of Korean Medicine, Daegu Haany University, 1 Hannydaero, Gyeongsan, Gyeongsangbuk-Do 712-715, Republic of Korea.
authors: Hee Duk
authors: HD
authors: An
authors: The Medical Research Center for Globalization of Herbal Medicine, College of Korean Medicine, Daegu Haany University, 1 Hannydaero, Gyeongsan, Gyeongsangbuk-Do 712-715, Republic of Korea ; Department of Preventive Medicine, College of Korean Medicine, Daegu Haany University, 1 Hannydaero, Gyeongsan, Gyeongsangbuk-Do 712-715, Republic of Korea.
authors: Young Joon
authors: YJ
authors: Lee