title: Changes in obesity-related diseases and biochemical variables after laparoscopic sleeve gastrectomy: a two-year follow-up study.
abstract: BACKGROUND
  To evaluate changes in obesity-related diseases and micronutrients after laparoscopic sleeve gastrectomy (LSG).
  
  
  METHODS
  We started the procedure in May 2007, and by December 2011, 117 patients could be evaluated for a two year follow-up. Comparisons of preoperative status with 12 and 24 months postoperative status were made for body mass index (BMI), obesity-related diseases and micronutrients.
  
  
  RESULTS
  Major complications included bleeding requiring transfusion at 5.1%, leak at 1.7% and abscess without a visible leak at 0.9%. Mean BMI was reduced from 46.6 (standard deviation (SD) 6.0) kg/m2 to 30.6 (SD 5.6) kg/m2 at two years, and resolution occurred for 80.7% of patients with type 2 diabetes, 63.9% with hypertension, 75.8% with hyperlipidemia, 93.0% with sleep apnea, 31.4% with musculoskeletal pain, 85.4% with snoring and 73.3% with urinary incontinence. Amenorrhea resolved in all premenopausal females. The proportion of patients with symptomatic gastroesophageal reflux disease increased from 12.8% to 27.4%. The prevalence of patients with low ferritin-levels increased, while 25-hydroxyvitamin D (25(OH)D) deficiency decreased postoperatively.
  
  
  CONCLUSIONS
  LSG is an effective procedure for morbid obesity and obesity-related diseases, but the technique should be further explored particularly to avoid gastroesophageal reflux.
authors: Department of Surgery, Førde Central Hospital, 6807 Førde, Norway. villy.vage@helse-forde.no.
authors: Villy
authors: V
authors: Våge
authors: Vetle Aaberge
authors: VA
authors: Sande
authors: Gunnar
authors: G
authors: Mellgren
authors: Camilla
authors: C
authors: Laukeland
authors: Jan
authors: J
authors: Behme
authors: John Roger
authors: JR
authors: Andersen
mesh_terms: D000328:Adult; D050110:Bariatric Surgery / Q000379:methods*; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D018977:Micronutrients / Q000097:blood; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000150:complications / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D011446:Prospective Studies; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D018977:Micronutrients