title: Differential expression of insulin-like growth factor 1 in human primary liver cancer.
abstract: Insulin-like Growth Factor 1 (IGF-1) antigen was immunohistochemically examined in 28 patients of the primary hepatocellular carcinoma with hepatectomy. IGF-1 was expressed in 93% (26/28) of the primary lesion and 100% (28/28) of the normal liver. Compared with expression in normal liver, decreased expressions in primary lesions were noted in 36% (10/28) for IGF-1. Histological examination revealed that there were significant correlations between patients with decreased expressions of IGF-1 in primary lesions and poor differentiated hepatocellular carcinoma, and portal vein infiltration. These results indicate that expression of IGF-1 has the relationship with the differentiation in human primary hepatocellular carcinoma.
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Yasuharu
authors: Y
authors: Ikeda
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Kiyoshi
authors: K
authors: Kajiyama
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Yo-Ichi
authors: Y
authors: Yamashita
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Toru
authors: T
authors: Ikegami
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Hideaki
authors: H
authors: Uchiyama
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Yuji
authors: Y
authors: Soejima
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Hirofumi
authors: H
authors: Kawanaka
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Tetsuo
authors: T
authors: Ikeda
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Masaru
authors: M
authors: Morita
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Eiji
authors: E
authors: Oki
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Hiroshi
authors: H
authors: Saeki
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Taketoshi
authors: T
authors: Suehiro
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Kohshi
authors: K
authors: Mimori
authors: Department of Surgery, Kyushu University Beppu Hospital, Beppu 874-0838, Japan.
authors: Keishi
authors: K
authors: Sugimachi
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Ken
authors: K
authors: Shirabe
authors: Department of Surgery and Science, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan.
authors: Yoshihiko
authors: Y
authors: Maehara
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009361:Neoplasm Invasiveness / Q000235:genetics; D011169:Portal Vein / Q000473:pathology; D019043:Vascular Neoplasms / Q000473:pathology
chemical_list: D007334:Insulin-Like Growth Factor I