title: Getting myosin-V on the right track: tropomyosin sorts transport in yeast.
abstract: Recent studies have revealed a novel mechanism of myosin regulation in which the actin-binding protein tropomyosin converts atypical type-V myosins into processive cargo transporters. To achieve this, tropomyosin's primary role appears to lie in its ability to influence myosin's enzyme kinetics, prolonging the strong actin-bound ADP/apo state to enable hand-over-hand walking of myosin-V dimers along actin tracks. Activation of myosin-V mediated transport by tropomyosin underscores its function in helping to direct cargos to specific actin tracks and subcellular destinations. This type of regulation supports the broader notion that tropomyosin plays a key role in actomyosin sorting.
authors: Department of Molecular Physiology & Biophysics; University of Vermont; Burlington, VT USA.
authors: Luther W
authors: LW
authors: Pollard
authors: Department of Molecular Physiology & Biophysics; University of Vermont; Burlington, VT USA.
authors: Matthew
authors: M
authors: Lord
mesh_terms: D008841:Actin Cytoskeleton / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D029702:Schizosaccharomyces pombe Proteins; D009218:Myosins
keywords: actin; actomyosin sorting; duty ratio; intracellular transport; myosin-V; processivity; tropomyosin