title: pH-Responsive Theranostic Polymer-Caged Nanobins (PCNs): Enhanced Cytotoxicity andT1MRI Contrast by Her2-Targeting.
abstract: A PCN theranostic platformcomprises a doxorubicin (DXR)-loaded liposomal core and an acid-sensitive polymer shell that is functionalized with Herceptin and GdIII-based MRI contrast agents. In vitro testing reveals a 14-fold increase in DXR-based cytotoxicity versus a non-targeted analogue and an 120-fold improvement in cellular GdIII-uptake in comparison with clinically approved DOTA-GdIII, leading to significantT1MRI contrast enhancement.
authors: Department of Chemistry, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Bong Jin
authors: BJ
authors: Hong
authors: Department of Chemical & Biological Engineering, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Elden P
authors: EP
authors: Swindell
authors: Department of Chemistry, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Keith W
authors: KW
authors: Macrenaris
authors: Department of Chemistry, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Patrick L
authors: PL
authors: Hankins
authors: Department of Chemistry, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Anthony J
authors: AJ
authors: Chipre
authors: Department of Chemistry, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Daniel J
authors: DJ
authors: Mastarone
authors: Department of Chemistry, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Richard W
authors: RW
authors: Ahn
authors: Department of Chemistry, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Thomas J
authors: TJ
authors: Meade
authors: Department of Chemistry, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Thomas V
authors: TV
authors: O'Halloran
authors: Department of Chemistry, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA).
authors: Sonbinh T
authors: ST
authors: Nguyen
keywords: cancer targeting; drug delivery; magnetic resonance imaging; pH-responsive drug release; theranostics