title: CXCR3 polymorphism is associated with male gender and pleuritis in patients with systemic lupus erythematosus.
abstract: BACKGROUND
  Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease involving multiple organs. Chemokines and their receptors play an important role in the pathogenesis of SLE. Lymphocytes expressing CXCR3, chemokine receptors of CXCL4, 9, 10, and 11, increase in patients with SLE and animal models, particularly in those with skin manifestations and nephritis. We investigated CXCR3 genetic polymorphisms in patients with SLE and their association with clinical manifestations.
  
  
  METHODS
  A total of 346 patients with SLE and 540 healthy controls were investigated for CXCR3 intron 1 polymorphisms rs2280964 and rs34334103 by Taqman analysis.
  
  
  RESULTS
  rs2280964 and rs34334103 were not associated with all patients with SLE, but rs34334103 showed a significant association with male patients with SLE. Among the clinical manifestations, pleuritis was associated with the rs34334103 polymorphism.
  
  
  CONCLUSIONS
  The CXCR3 polymorphism rs34334103 was associated with male gender and pleuritis in patients with SLE.
authors: Division of Rheumatology, Department of Internal Medicine, Seoul National University Medical College, Seoul, Republic of Korea.
authors: Churl Hyun
authors: CH
authors: Im
authors: Division of Rheumatology, Department of Internal Medicine, Seoul National University Medical College, Seoul, Republic of Korea.
authors: Ji Ah
authors: JA
authors: Park
authors: Division of Rheumatology, Department of Internal Medicine, Seoul National University Medical College, Seoul, Republic of Korea.
authors: Jeong Yeon
authors: JY
authors: Kim
authors: Division of Rheumatology, Department of Internal Medicine, Seoul National University Medical College, Seoul, Republic of Korea.
authors: Eun Young
authors: EY
authors: Lee
authors: Division of Rheumatology, Department of Internal Medicine, Seoul National University Medical College, Seoul, Republic of Korea.
authors: Eun Bong
authors: EB
authors: Lee
authors: Center for Genomic Science, The National Institute of Health, Seoul, Republic of Korea. Electronic address: yeonmaru@gmail.com.
authors: Yeonjung
authors: Y
authors: Kim
authors: Division of Rheumatology, Department of Internal Medicine, Seoul National University Medical College, Seoul, Republic of Korea; WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Medical Research Center, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, 110-799 Seoul, Republic of Korea. Electronic address: ysong@snu.ac.kr.
authors: Yeong Wook
authors: YW
authors: Song
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010998:Pleurisy / Q000209:etiology*; D011110:Polymorphism, Genetic; D054367:Receptors, CXCR3 / Q000235:genetics*; D012737:Sex Factors; D055815:Young Adult
chemical_list: D054367:Receptors, CXCR3