title: Computational large-scale mapping of protein-protein interactions using structural complexes.
abstract: Although the identification of protein interactions by high-throughput methods progresses at a fast pace, "interactome" datasets still suffer from high rates of false positives and low coverage. To map the interactome of any organism, this unit presents a computational framework to predict protein-protein or gene-gene interactions utilizing experimentally determined evidence of structural complexes, atomic details of binding interfaces and evolutionary conservation.
authors: National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland.
authors: Benjamin
authors: B
authors: Shoemaker
authors: National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland.
authors: Stefan
authors: S
authors: Wuchty
authors: National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland.
authors: Anna R
authors: AR
authors: Panchenko
mesh_terms: D019295:Computational Biology / Q000379:methods*; D020407:Internet; D008958:Models, Molecular; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D012984:Software
chemical_list: D011506:Proteins
keywords: IBIS; Inferred Biomolecular Interactions Server; binding interface; protein interaction; structural complex