title: Alcohol abuse in deceased liver donors: impact on post-transplant outcomes.
abstract: BACKGROUND
  Many deceased liver donors with a history of alcohol abuse are excluded based upon medical history alone. This paper summarizes the transplant outcomes for a large number of deceased liver donors with a documented history of alcohol abuse.
  
  
  METHODS
  The records for 1478 consecutive deceased liver donors were reviewed (2001-2012). As per the United Network for Organ Sharing criteria, heavy alcohol use by an organ donor is defined as chronic intake of two or more drinks per day. Donors with a documented history of alcohol abuse were divided into three groups according to duration of abuse (<10 years, 10-24 years and 25 + years). Reperfusion biopsies are reported. Outcomes include biopsy appearance, early graft function and early and late graft survival.
  
  
  RESULTS
  There were 161 donors with alcohol abuse: <10 years (29%); 10-24 years (42%); and ≥25 years (29%). Risk of 90-day graft loss for these three groups was: 0%, 3% and 2%, compared to 3% for all other donors (P = 0.62). Graft survival at 1 year for donor grafts with and without alcohol abuse was 89% and 87% (P = 0.52). There was no difference in early graft function. Cox proportional hazards modelling for graft survival demonstrates no statistically significant difference in survival up to 10 years post-transplant.
  
  
  CONCLUSIONS
  This study demonstrates successful transplantation of a large number of deceased donor liver grafts from donors with a documented history of alcohol abuse (n = 161; 11% of all grafts). These extended criteria donor allografts may, therefore, be utilized successfully with similar outcomes.
authors: Transplant Division, Indiana University School of Medicine, Indianapolis, Indiana, USA.
authors: Richard S
authors: RS
authors: Mangus
authors: Chandrashekhar A
authors: CA
authors: Kubal
authors: Jonathan A
authors: JA
authors: Fridell
authors: Jose M
authors: JM
authors: Pena
authors: Evan M
authors: EM
authors: Frost
authors: A
authors: A
authors: Joseph Tector
mesh_terms: D000437:Alcoholism / Q000150:complications*; D046148:Donor Selection; D005260:Female; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016031:Liver Transplantation / Q000706:statistics & numerical data*; D008297:Male; D055031:Primary Graft Dysfunction / Q000453:epidemiology* / Q000209:etiology*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D014019:Tissue Donors
keywords: alcohol abuse; extended criteria donors; orthotopic liver transplant; outcomes