title: Efficacy of betamethasone on the fetal motion and biophysical profile and amniotic fluid index in preterm fetuses.
abstract: The term ofpreterm birth is used to define the premature neonates considering pregnancy age. In less than 34 week pregnancies, corticosteroids are prescribed to promote embryos' lung maturity. The presents study aimed at evaluating effects of betamethasone injection on feeling embryo motion by mother and index and biophysical profile in preterm pregnancies. In a descriptive-analytical study, 40 pregnant women with the pregnancy age of 30-34 weeks were evaluated. Embryo motion and index and biophysical profile of the amniotic fluid were checked before prescription of double dosage of muscular betamethasone (12 mg) at a 24 h time interval. The injection was repeated for 24 and 48 h after the first injection. The resulted outcomes were compared with those results related to before betamethasone injection. In this study, there was statistically meaningful relationship between embryo motions before injection of betamethasone and 12 h after its injection (p = 0.03). Also, there was a significant relationship between embryo motions 24 and 48 h after injection of betamethasone (p = 0.001). In other words, the embryo motions decreased 12 h after injection of betamethasone. They were improved 48 h after betamethasone injection. But, index and biophysical profile results of amniotic fluid were left unchanged. Application of betamethasone leads to evident but transient decrease in embryo motions. Although motion element of index and biophysical profile of amniotic fluid which is one of the tests used in evaluating the embryo health is fixed and normal, it can be concluded that injection of betamethasone may not affect embryo health.
authors: Department of Gynecology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Shamsi
authors: S
authors: Abbasalizadeh
authors: Department of Gynecology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Zahra Neghadan
authors: ZN
authors: Pharabar
authors: Department of Gynecology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Fatmeh
authors: F
authors: Abbasalizadeh
authors: Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Morteza
authors: M
authors: Ghojazadeh
authors: Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Mohamad
authors: M
authors: Goldust
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000653:Amniotic Fluid / Q000187:drug effects* / Q000378:metabolism; D003907:Dexamethasone / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D005324:Fetal Movement / Q000187:drug effects*; D005865:Gestational Age; D006801:Humans; D007273:Injections, Intramuscular; D011247:Pregnancy; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D003907:Dexamethasone