title: Prognostic significance of TBX2 expression in non-small cell lung cancer.
abstract: T-box2 (TBX2) expression has been reported to be related to aggressive tumor features. However, the role of TBX2 in non-small-cell lung cancer (NSCLC) tumorigenesis has never been elucidated. So we aimed at investigating the potential role of TBX2 in NSCLC. TBX2 expression was evaluated by qRT-PCR and Western blotting in 50 paired fresh lung cancer tissues as well as immunohistochemistry on 212 paraffin-embedded sections. We showed that the expression level of TBX2 was significantly increased in NSCLC as compared with the adjacent noncancerous tissue. Positive expression level of TBX2 was associated with histological type, lymph node metastasis and distant metastasis. Kaplan-Meier survival curves showed that positive expression level of TBX2 was associated with poor overall survival (OS) and progression-free survival of NSCLC patients. Results showed that TBX2 positivity was an independent prognostic factor for OS (HR 1.87, 95% CI 1.004-3.153, p = 0.012). On the basis of these results, we suggested that TBX2 protein expression may be an unfavorable independent prognostic parameter for NSCLC.
authors: Emergency Department, Shandong Provincial Hospital Affiliated to Shandong University, 324 Jing Wu Road, Jinan, 250021, Shandong, China.
authors: Bo
authors: B
authors: Hu
authors: Hai-Ping
authors: HP
authors: Mu
authors: Yu-Qing
authors: YQ
authors: Zhang
authors: Chong-Yi
authors: CY
authors: Su
authors: Jian-Tao
authors: JT
authors: Song
authors: Chong
authors: C
authors: Meng
authors: Dong-Xing
authors: DX
authors: Liu
mesh_terms: D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D020825:T-Box Domain Proteins / Q000378:metabolism*
chemical_list: C097348:T-Box Domain Protein 2; D020825:T-Box Domain Proteins