title: Reply to Shin and Bayry on "An age-related decline of CD62L and vaccine response: a role of microRNA 92a?".
abstract: Aging of the human body affects the immune system by a decline in the ability to raise a response to challenges such as microbial infections or vaccinations. In the very elderly, the decline in such functions appears to relate to a reduced expression of certain co-stimulatory molecules expressed by T lymphocytes. More recently, attention has been drawn to the adhesion molecule CD62L, where differences in expression and function of this molecule between younger and older individuals are suspected to be a part of immunosenescence in the elderly.
authors: Department of Biomedicine; Aarhus University; Aarhus, Denmark.
authors: Thomas
authors: T
authors: Vorup-Jensen
authors: Department of Biomedicine; Aarhus University; Aarhus, Denmark.
authors: Carina
authors: C
authors: Rosenberg
authors: Department of Clinical Medicine; Aarhus University; Aarhus, Denmark; Department of Infectious Diseases; Aarhus University Hospital-Skejby; Aarhus, Denmark.
authors: Eskild
authors: E
authors: Petersen
mesh_terms: D000375:Aging / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D006801:Humans; D019041:L-Selectin / Q000502:physiology*; D008297:Male
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D019041:L-Selectin
keywords: CD62L; HBV; adhesion molecule; age; glycosylation