title: Safety, specificity and immunogenicity of a PrP(Sc)-specific prion vaccine based on the YYR disease specific epitope.
abstract: Prions are a novel form of infectivity based on the misfolding of a self-protein (PrP(C)) into a pathological, infectious isomer (PrP(Sc)). The current uncontrolled spread of chronic wasting disease in cervids, coupled with the demonstrated zoonotic nature of select livestock prion diseases, highlights the urgent need for disease management tools. While there is proof-of-principle evidence for a prion vaccine, these efforts are complicated by the challenges and risks associated with induction of immune responses to a self-protein. Our priority is to develop a PrP(Sc)-specific prion vaccine based on epitopes that are uniquely exposed upon misfolding. These disease specific epitopes (DSEs) have the potential to enable specific targeting of the pathological species through immunotherapy. Here we review outcomes of the translation of a prion DSE into a PrP(Sc)-specific vaccine based on the criteria of immunogenicity, safety and specificity.
authors: Ryan
authors: R
authors: Taschuk
authors: Kristen
authors: K
authors: Marciniuk
authors: Pekka
authors: P
authors: Määttänen
authors: Claudia
authors: C
authors: Madampage
authors: Peter
authors: P
authors: Hedlin
authors: Andrew
authors: A
authors: Potter
authors: Jeremy
authors: J
authors: Lee
authors: Neil R
authors: NR
authors: Cashman
authors: Philip J
authors: PJ
authors: Griebel
authors: Scott
authors: S
authors: Napper
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D018620:PrPSc Proteins / Q000737:chemistry / Q000276:immunology*; D017096:Prion Diseases / Q000276:immunology / Q000517:prevention & control*; D017510:Protein Folding; D057165:Proteostasis Deficiencies / Q000276:immunology / Q000517:prevention & control; D014612:Vaccines / Q000009:adverse effects / Q000276:immunology*
chemical_list: D000939:Epitopes; D018620:PrPSc Proteins; D014612:Vaccines