title: [Voltage-dependent potassium channel and calcium-activated potassium channel current changes of peripheral blood T-lymphocytes from hypertensive patients in Xinjiang Kazakh].
abstract: OBJECTIVE
  To observe the current changes of voltage-dependent potassium channel (Kv1.3 potassium channel) and calcium-activated potassium channel (IKCa1 potassium channel) in peripheral blood T-lymphocyte derived from hypertensive patients of Xinjiang Kazakh.
  
  
  METHODS
  Twenty randomly selected untreated Kazakh hypertensive patients and 20 Kazakh healthy subjects from Xinjiang were included in this study. T-lymphocytes were isolated from peripheral blood with magnetic cell sorting, the whole-cell currents of Kv1.3 and IKCa1 potassium channels were recorded with patch-clamp technique.
  
  
  RESULTS
  (1) The current density of Kv1.3 potassium channel was significantly higher in the hypertensive group [(280 ± 74) pA/pF (n = 39)] than that in the control group [(179 ± 51) pA/pF (n = 38), P < 0.01], while the membrane capacitance was similar between the two groups. (2) The current density of IKCa1 potassium channel was also significantly higher in the hypertensive group [(198 ± 44) pA/pF (n = 28)] than that in the control group [(124 ± 43) pA/pF (n = 26), P < 0.01], while the membrane capacitance was also similar between the two groups.
  
  
  CONCLUSIONS
  The T-lymphocytes Kv1.3 potassium channel and IKCa1 potassium channel current densities are higher in hypertensive patients in Xinjiang Kazakh suggesting a potential role of Kv1.3 and IKCa1 potassium channels activation in the pathophysiology of hypertension.
authors: Department of Cardiology, First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, China.
authors: Qiu-bing
authors: QB
authors: Zhang
authors: Email: zymdxx@163.com.
authors: Yuan-ming
authors: YM
authors: Zhang
authors: Lu-feng
authors: LF
authors: Cheng
authors: Qing-yan
authors: QY
authors: Yuan
authors: Gui-ming
authors: GM
authors: Zhang
authors: Ping
authors: P
authors: Liang
authors: Fang
authors: F
authors: Gou
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D051660:Intermediate-Conductance Calcium-Activated Potassium Channels / Q000502:physiology*; D051664:Kv1.3 Potassium Channel / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000502:physiology*
chemical_list: D051660:Intermediate-Conductance Calcium-Activated Potassium Channels; C496923:KCNN4 protein, human; D051664:Kv1.3 Potassium Channel