title: Powerful partnership: crosstalk between pannexin 1 and the cytoskeleton.
abstract: The roles of pannexin 1 (Panx1) large-pore ion and metabolite channels are becoming recognized in many physiological and pathophysiological scenarios. Recent evidence has tightly linked Panx1 trafficking and function to the cytoskeleton, a multi-component network that provides critical structural support, transportation, and scaffolding functions in all cell types. Here we review early work demonstrating the mechanosensitive activation of Panx1 channels, and expand on more recent evidence directly linking Panx1 to the cytoskeleton. Further, we examine the reciprocal regulation between Panx1 and the cytoskeleton, and discuss the involvement of Panx1 in cytoskeletal-regulated cell behaviors. Finally, we identify important gaps in the current knowledge surrounding this emerging Panx1-cytoskeleton relationship.
authors: Division of Medical Sciences, University of Victoria Victoria, BC, Canada.
authors: Andrew K J
authors: AK
authors: Boyce
authors: Division of Medical Sciences, University of Victoria Victoria, BC, Canada.
authors: Leigh E
authors: LE
authors: Wicki-Stordeur
authors: Division of Medical Sciences, University of Victoria Victoria, BC, Canada ; Department of Biology, University of Victoria Victoria, BC, Canada ; Department of Biochemistry and Microbiology, University of Victoria Victoria, BC, Canada ; Department of Cellular and Physiological Sciences and Island Medical Program, University of British Columbia Vancouver, BC, Canada.
authors: Leigh Anne
authors: LA
authors: Swayne
keywords: Panx1; actin; cytoskeleton; mechanosensitive channels; mechanotransduction; pannexin