title: Stressing on the nucleolus in cardiovascular disease.
abstract: The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
authors: Department of Biology, San Diego State University Heart Institute, San Diego State University, San Diego, CA 92182, USA.
authors: Nirmala
authors: N
authors: Hariharan
authors: Department of Biology, San Diego State University Heart Institute, San Diego State University, San Diego, CA 92182, USA. Electronic address: heartman4ever@icloud.com.
authors: Mark A
authors: MA
authors: Sussman
mesh_terms: D002318:Cardiovascular Diseases / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D002466:Cell Nucleolus / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D000071837:Fibrillins; D006801:Humans; D008840:Microfilament Proteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*; D000090243:Nucleophosmin; D010750:Phosphoproteins / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D015398:Signal Transduction; D000097796:Nucleolin
chemical_list: D000071837:Fibrillins; D008840:Microfilament Proteins; D009687:Nuclear Proteins; D000090243:Nucleophosmin; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D000097796:Nucleolin
keywords: Cardiovascular; Disease; Heart; Nucleolus