title: Acute toxicity study of Vasaguduchyadi Kwatha: A compound Ayurvedic formulation.
abstract: Vasaguduchyadi Kwatha is a compound Ayurvedic formulation, indicated for the treatment of liver diseases, especially for Kamala (jaundice) and Panduroga (anemia). However, till date, no safety profile of this formulation has been reported; hence, in the present study, freshly prepared and market samples of Vasaguduchyadi Kwatha were evaluated for acute toxicity. Acute toxicity test was evaluated as per OECD 425 guidelines with 5 000 mg/kg as limit test in Wistar strain albino rats. Test formulations were administered to overnight fasted animals and parameters like body weight, behavioral changes, and mortality were assessed for 14 days. Hematological and biochemical parameters were assessed on 14(th) day. Results showed no significant changes in terms of behavioral changes, mortality, and body weight. Both the samples did not affect any of the hematological parameters. However, increase in blood urea level was observed. This study shows that both the samples of Vasaguduchyadi Kwatha are relatively safe up to the dose of 5 g/kg. However, further chronic toxicity evaluation is necessary to establish its safety profile on chronic administration.
authors: Lecturer and Head, Department of Pharmacology, Institute of Ayurvedic Pharmaceutical Sciences, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors: Kalpu N
authors: KN
authors: Kotecha
authors: Drug Discovery Team, Research and Development, The Himalaya Drug Company, Makali, Bangalore, India.
authors: B K
authors: BK
authors: Kotecha
authors: Head, Pharmaceutical Chemistry Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, India.
authors: Vinay J
authors: VJ
authors: Shukla
authors: Professor and Head, Department of Rasa Shastra and Bhaishjya Kalpana, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India.
authors: Pradipkumar
authors: P
authors: Prajapati
authors: Director, Reseach and Development, SDM Centre for Research in Ayurveda and Allied Sciences, Kuthpady, Udupi, Karnataka, India.
authors: B
authors: B
authors: Ravishankar
keywords: Acute toxicity; Kamala; Vasaguduchyadi Kwatha; hepatoprotective