title: Role of oral Polypodium leucotomos extract in dermatologic diseases: a review of the literature.
abstract: Polypodium leucotomos extract (PLE), derived from the tropical fern of Polypodiaceae family, has properties ranging from immunomodulatory and antioxidative to photoprotective. It is these multiple mechanisms of action, in combination with a favorable side effect profile, which makes PLE a promising adjunctive treatment for several dermatologic disorders. Studies are summarized on the use and potential applications of PLE in the treatment or management of photodermatoses, vitiligo, melasma, psoriasis, atopic dermatitis, and more recently, in minimizing infections in high-performance athletes. More data, however, with larger sample sizes are needed to confirm these benefits.
authors: Samreen Z
authors: SZ
authors: Choudhry
authors: Neal
authors: N
authors: Bhatia
authors: Roger
authors: R
authors: Ceilley
authors: Firas
authors: F
authors: Hougeir
authors: Robert
authors: R
authors: Lieberman
authors: Iltefat
authors: I
authors: Hamzavi
authors: Henry W
authors: HW
authors: Lim
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003879:Dermatologic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D032494:Polypodium / Q000737:chemistry*; D012871:Skin Diseases / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D003879:Dermatologic Agents; D010936:Plant Extracts