title: Multimodal image driven patient specific tumor growth modeling.
abstract: Personalized tumor growth model using clinical imaging data is valuable in tumor staging and therapy planning. In this paper, we build a patient specific tumor growth model based on longitudinal dual phase CT and FDG-PET. We propose a reaction-advection-diffusion model integrating cancerous cell proliferation, infiltration, metabolic rate and extracellular matrix biomechanical response. We then develop a scheme to bridge our model with multimodal radiologic images through intracellular volume fraction (ICVF) and Standardized Uptake Value (SUV). The model was evaluated by comparing the predicted tumors with the observed tumors in terms of average surface distance (ASD), root mean square difference (RMSD) of the ICVF map, the average ICVF difference (AICVFD) of tumor surface and the tumor relative volume difference (RVD) on six patients with pathologically confirmed pancreatic neuroendocrine tumors. The ASD between the predicted tumor and the reference tumor was 2.5 +/- 0.7 mm, the RMSD was 4.3 +/- 0.6%, the AICVFD was 2.6 +/- 0.8%, and the RVD was 7.7 +/- 1.9%.
authors: Radiology and Imaging Sciences, NIH, USA.
authors: Yixun
authors: Y
authors: Liu
authors: Endocrine Oncology Branch, National Cancer Institute, NIH, USA.
authors: Samira M
authors: SM
authors: Sadowski
authors: Endocrine Oncology Branch, National Cancer Institute, NIH, USA.
authors: Allison B
authors: AB
authors: Weisbrod
authors: Endocrine Oncology Branch, National Cancer Institute, NIH, USA.
authors: Electron
authors: E
authors: Kebebew
authors: Radiology and Imaging Sciences, NIH, USA.
authors: Ronald M
authors: RM
authors: Summers
authors: Radiology and Imaging Sciences, NIH, USA.
authors: Jianhua
authors: J
authors: Yao
mesh_terms: D000465:Algorithms; D049109:Cell Proliferation; D003198:Computer Simulation; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008954:Models, Biological; D064847:Multimodal Imaging / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000503:physiopathology*; D018802:Patient-Centered Care / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods; D047368:Tumor Burden
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18