title: Kappa statistic for clustered matched-pair data.
abstract: Kappa statistic is widely used to assess the agreement between two procedures in the independent matched-pair data. For matched-pair data collected in clusters, on the basis of the delta method and sampling techniques, we propose a nonparametric variance estimator for the kappa statistic without within-cluster correlation structure or distributional assumptions. The results of an extensive Monte Carlo simulation study demonstrate that the proposed kappa statistic provides consistent estimation and the proposed variance estimator behaves reasonably well for at least a moderately large number of clusters (e.g., K ≥50). Compared with the variance estimator ignoring dependence within a cluster, the proposed variance estimator performs better in maintaining the nominal coverage probability when the intra-cluster correlation is fair (ρ ≥0.3), with more pronounced improvement when ρ is further increased. To illustrate the practical application of the proposed estimator, we analyze two real data examples of clustered matched-pair data.
authors: UCB BioSciences, Inc., 8010 Arco Corporate Drive, Raleigh, NC 27617, U.S.A.
authors: Zhao
authors: Z
authors: Yang
authors: Ming
authors: M
authors: Zhou
mesh_terms: D016000:Cluster Analysis; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D006801:Humans; D009010:Monte Carlo Method; D010280:Parathyroid Glands / Q000473:pathology; D049268:Positron-Emission Tomography; D011570:Psychiatry / Q000379:methods; D011795:Surveys and Questionnaires; D015899:Tomography, Emission-Computed, Single-Photon
keywords: agreement; clustered matched-pair data; confidence interval; delta method; kappa statistic