title: Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease.
abstract: The β-amyloid precursor protein (APP) has been extensively studied for its role as the precursor of the β-amyloid protein (Aβ) of Alzheimer's disease. However, the normal function of APP remains largely unknown. This article reviews studies on the structure, expression and post-translational processing of APP, as well as studies on the effects of APP in vitro and in vivo. We conclude that the published data provide strong evidence that APP has a trophic function. APP is likely to be involved in neural stem cell development, neuronal survival, neurite outgrowth and neurorepair. However, the mechanisms by which APP exerts its actions remain to be elucidated. The available evidence suggests that APP interacts both intracellularly and extracellularly to regulate various signal transduction mechanisms. This article reviews studies on the structure, expression and post-translational processing of β-amyloid precursor protein (APP), as well as studies on the effects of APP in vitro and in vivo. We conclude that the published data provide strong evidence that APP has a trophic function. APP is likely to be involved in neural stem cell development, neuronal survival, neurite outgrowth and neurorepair. However, the mechanisms by which APP exerts its actions remain to be elucidated. The available evidence suggests that APP interacts both intracellularly and extracellularly to regulate various signal transduction mechanisms.
authors: Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia.
authors: Edgar
authors: E
authors: Dawkins
authors: David H
authors: DH
authors: Small
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D006801:Humans; D051379:Mice; D058953:Neural Stem Cells / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D016564:Amyloid beta-Protein Precursor
keywords: Alzheimer's disease; amyloid precursor protein; growth factor; heparin; neurotrophic; receptor