title: Effects of freeze-dried red wine on cardiac function and ECG of the Langendorff-perfused rat heart.
abstract: The effect of freeze-dried red wine (FDRW) on cardiac function and electrocardiogram (ECG) in Langendorff-isolated rat hearts was investigated. FDRW significantly decreased left ventricular pressure and coronary perfusion pressure, the latter being dependent on the activation of both phosphatidylinositol 3-kinase and eNOS. FDRW did not affect the QRS and QT interval in the ECG, although at 56 μg of gallic acid equivalents/mL, it prolonged PQ interval and induced a second-degree atrioventricular block in 3 out of 6 hearts. This is the first study demonstrating that at concentrations resembling a moderate consumption of red wine, FDRW exhibited negative inotropic and coronary vasodilating activity leaving unaltered ECG, whereas at very high concentrations, it induced arrhythmogenic effects.
authors: a Dipartimento di Scienze della Vita, Università degli Studi di Siena, via A. Moro 2, 53100 Siena, Italy.
authors: Antonella
authors: A
authors: Ferrara
authors: Fabio
authors: F
authors: Fusi
authors: Beatrice
authors: B
authors: Gorelli
authors: Giampietro
authors: G
authors: Sgaragli
authors: Simona
authors: S
authors: Saponara
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004562:Electrocardiography; D005612:Freeze Drying; D006321:Heart / Q000502:physiology*; D006339:Heart Rate; D008297:Male; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D014920:Wine
chemical_list: D002316:Cardiotonic Agents