title: Intensive aerobic and muscle endurance exercise in patients with systemic sclerosis: a pilot study.
abstract: BACKGROUND
  No previous studies have examined the effect of intensive exercise in systemic sclerosis patients with pulmonary impairment. The objective of this study was to examine the effect of an eight-week intensive aerobic exercise and muscle endurance training program for patients with systemic sclerosis with 50-100% of forced vital capacity.
  
  
  METHODS
  A single-subject experimental design with repeated systematic measures during a six week A-phase (non-interventional baseline period) and an eight week B-phase (exercise intervention period) was used. Three women and one man with median age 66 years and median disease duration of 3.5 years completed aerobic exercise corresponding to 15 on the Borg RPE scale (strenuous) and muscular endurance training three times/week. Physical capacity (six-minute walk test), aerobic capacity (submaximal treadmill test) and muscle endurance in shoulder and hip flexion (Functional Index 2) were assessed every other week throughout the 14-week study. Activity limitation (Health Assessment Questionnaire), quality of life (Short Form 36), Raynaud, Fatigue and Global Health during the recent week (Visual Analogue Scales) were assessed at weeks 0, 6, 14.
  
  
  RESULTS
  Three participants improved significantly in muscular endurance, and two participants improved significantly or clinically relevant in aerobic capacity. All other variables remained unchanged, except for a trend towards reduced fatigue.
  
  
  CONCLUSIONS
  This eight week exercise program was largely successful with positive effects on aerobic capacity and muscle endurance.
  
  
  BACKGROUND
  Clinicaltrials.gov Identifier: NCT01813578.
authors: Department of Neurobiology, Care Science and Society, Division of Physical Therapy, Karolinska Institutet, Stockholm, Sweden. helene.alexanderson@karolinska.se.
authors: Helene
authors: H
authors: Alexanderson
authors: Jenny
authors: J
authors: Bergegård
authors: Lena
authors: L
authors: Björnådal
authors: Annica
authors: A
authors: Nordin
mesh_terms: D000328:Adult; D000368:Aged; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods*; D005221:Fatigue / Q000175:diagnosis / Q000503:physiopathology; D005260:Female; D006621:Hip Joint / Q000502:physiology; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010809:Physical Fitness / Q000502:physiology*; D010865:Pilot Projects; D011788:Quality of Life; D016059:Range of Motion, Articular / Q000502:physiology; D012595:Scleroderma, Systemic / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D012785:Shoulder Joint / Q000502:physiology; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014797:Vital Capacity / Q000502:physiology; D016138:Walking / Q000502:physiology