title: Relationship of maternal serum resistin and visfatin levels with gestational diabetes mellitus.
abstract: BACKGROUND
  Adiponectin, resistin and visfatin are thought to play role in the pathophysiology of gestational diabetes (GDM). In this study, we aimed to investigate the association of maternal second trimester serum resistin and visfatin levels with GDM.
  
  
  METHODS
  Screening and diagnosis for GDM was performed between the 24-28th gestational weeks. About 40 women diagnosed with GDM and 40 non-diabetic women constituted the study and control groups, respectively. Groups were compared for second trimester maternal serum resistin, visfatin and HbA1c levels, HOMA-IR and postpartum 75 g OGTT results.
  
  
  RESULTS
  Mean serum resistin (p = 0.071) and visfatin (p = 0.194) levels were similar between the groups. However, mean BMI (p = 0.013), HOMA-IR (p = 0.019), HbA1c (p < 0.0001) and birth weight (p = 0.037) were significantly higher in GDM group compared to controls. Type 2 diabetes and impaired glucose tolerance were detected in 2 (5%) and 7 (20%) women in the GDM group, respectively, with 75 g OGTT performed at the postpartum 6th week. Resistin levels of patients with GDM and postpartum glucose intolerance were higher than those with GDM but no postpartum glucose intolerance (p = 0.012). Visfatin levels in the GDM group showed a positive correlation with biparietal diameter, head circumference, abdominal circumference and femur length (p < 0.05).
  
  
  CONCLUSIONS
  Maternal serum resistin and visfatin levels are unchanged in GDM. In patients with GDM, second trimester resistin levels may be predictive for postpartum glucose intolerance and second trimester visfatin levels may be related with fetal biometric measurements. Further larger studies are needed.
authors: Department of Obstetrics and Gynecology, Medical Faculty, Abant Izzet Baysal University , Bolu , Turkey .
authors: Ahmet
authors: A
authors: Karatas
authors: Nilüfer
authors: N
authors: Tunçay Işikkent
authors: Tülay
authors: T
authors: Ozlü
authors: Hilmi
authors: H
authors: Demirin
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007333:Insulin Resistance / Q000502:physiology; D008137:Longitudinal Studies; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D052243:Resistin / Q000097:blood*; D018709:Statistics, Nonparametric
chemical_list: D016207:Cytokines; D006442:Glycated Hemoglobin; D054409:Nicotinamide Phosphoribosyltransferase; D052243:Resistin; C085455:nicotinamide phosphoribosyltransferase, human