title: Potential benefits of icosapent ethyl on the lipid profile: case studies.
abstract: The cardiovascular benefits of marine-derived omega-3 fatty acids are supported by epidemiologic and clinical studies. Both healthy patients and those with confirmed coronary heart disease are advised by the American Heart Association to consume omega-3 fatty acids either through dietary fatty fish or fish oil products. We present two case reports of patients with dyslipidemia who were switched from an omega-3 dietary supplement or a prescription omega-3 drug containing eicosapentaenoic acid (EPA) plus docosahexaenoic acid (DHA) to a new prescription EPA-only drug, icosapent ethyl (IPE). Products containing a combination of EPA and DHA, including dietary supplements and prescription products, are more likely to increase low-density lipoprotein cholesterol (LDL-C) levels compared with pure EPA-only products. The lipid profiles of these two patients were improved with IPE treatment, illustrating the potentially favorable effects of IPE compared with other products containing both EPA and DHA.
authors: Department of Pharmacy Practice, Creighton University School of Pharmacy and Health Professions, Omaha, NE, USA.
authors: Daniel E
authors: DE
authors: Hilleman
authors: Department of Pharmacy Practice, Creighton University School of Pharmacy and Health Professions, Omaha, NE, USA.
authors: Mark A
authors: MA
authors: Malesker
keywords: docosahexaenoic acid; eicosapentaenoic acid; fish oil; icosapent ethyl; lipids; omega-3 fatty acids