title: AZGP-1 immunohistochemical marker in prostate cancer: potential predictive marker of biochemical recurrence in post radical prostatectomy specimens.
abstract: One of the major challenges in prostate cancer research is to identify prognostic/predictive factors to distinguish aggressive disease from indolent one. To select prognostic/predictive markers of postoperative biochemical recurrence (BCR) that could be easily performed in daily pathology practice, the expression of 6 immunohistochemical markers including zinc-α-2-glycoprotein (AZGP-1), hCAP-D3, mucin 1, vimentin, E-cadherin, and ERG was assessed in a tissue microarray of 400 radical prostatectomy specimens. The expression levels were correlated with clinicopathologic factors and BCR. During the median follow-up period of 55 months, BCR occurred in 70 cases (17.5%). Low expression of AZGP-1 was noted in 76 cases (19.0%), whereas high expression of hCAP-D3, mucin 1, vimentin, and ERG was observed in 205 (51.3%), 81 (20.3%), 33 (8.3%), and 58 (14.5%) cases, respectively. Aberrant E-cadherin expression was noted in 29 cases (7.3%). By univariate analysis, BCR was associated with low expression of AZGP-1, high expression of hCAP-D3, and aberrant expression of E-cadherin. By multivariate analysis, only AZGP-1 remained an independent immunohistochemical factor, in addition to age, preoperative serum prostate-specific antigen level, Gleason score, tumor stage, and resection margin status. These results show that AZGP-1, hCAP-D3, and E-cadherin are potentially useful immunohistochemical markers to predict BCR, and that AZGP-1 can be used as an independent prognostic marker of aggressive prostate cancer.
authors: *Department of Pathology, Korea University Guro Hospital, Korea University College of Medicine †Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine §Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul ‡Department of Pathology, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea ∥Department of Pathology and Genomic Medicine, The Methodist Hospital, Weill Medical College of Cornell University, Houston, TX ¶Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors: Woon Yong
authors: WY
authors: Jung
authors: Chang Ohk
authors: CO
authors: Sung
authors: Sang Hak
authors: SH
authors: Han
authors: Kyungeun
authors: K
authors: Kim
authors: Misung
authors: M
authors: Kim
authors: Jae Y
authors: JY
authors: Ro
authors: Mun Jung
authors: MJ
authors: Kang
authors: Hanjong
authors: H
authors: Ahn
authors: Yong Mee
authors: YM
authors: Cho
mesh_terms: D054392:Adipokines; D000328:Adult; D000368:Aged; D015820:Cadherins / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D015534:Trans-Activators / Q000378:metabolism; D000071230:Transcriptional Regulator ERG; D014746:Vimentin / Q000378:metabolism; D000090203:Zn-Alpha-2-Glycoprotein
chemical_list: D054392:Adipokines; D015820:Cadherins; D002352:Carrier Proteins; D006023:Glycoproteins; D018396:Mucin-1; D009363:Neoplasm Proteins; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG; D014746:Vimentin; C488891:AZGP1 protein, human; D000090203:Zn-Alpha-2-Glycoprotein; C072312:ERG protein, human; C060192:MUC1 protein, human