title: How to successfully resect 70 % of the liver in pigs to model an extended hepatectomy with an insufficient remnant or liver transplantation with a small-for-size graft.
abstract: An insufficient remnant in extended hepatectomy and small-for-size graft in liver transplantation are critical matters in the field of liver surgery, and reliable and reproducible animal models that can provide clinically relevant and reliable data are needed. We herein describe our detailed surgical procedures for performing 70 % hepatectomy in pigs, and discuss the critical anatomical features, key techniques and pitfalls based on our experience. The porcine liver is divided into four lobes. The right lateral lobe (RLL) accounts for 30 % of the liver volume. Important points, such as selective temporal clamping of the arterial branch, confirmation of a related demarcation line, a two-step process to skeletonize Glisson's capsules during liver resection and selective ligation of the portal venous branch to the right medial lobe without inducing any subtle injuries to Glisson's capsules from the RLL to common bile duct, are discussed.
authors: Division of Hepato-Biliary-Pancreatic and Transplant Surgery, Department of Surgery, Kyoto University Graduate School of Medicine, 54 Shogoinkawara-cho, Sakyo-ku, Kyoto, 606-8507, Japan, horit@kuhp.kyoto-u.ac.jp.
authors: Tomohide
authors: T
authors: Hori
authors: Shintaro
authors: S
authors: Yagi
authors: Yusuke
authors: Y
authors: Okamua
authors: Taku
authors: T
authors: Iida
authors: Kohei
authors: K
authors: Ogawa
authors: Hirokazu
authors: H
authors: Tanaka
authors: Shoichi
authors: S
authors: Kageyama
authors: Hirofumi
authors: H
authors: Hirao
authors: Toshiyuki
authors: T
authors: Hata
authors: Izumi
authors: I
authors: Kirino
authors: Kazuyuki
authors: K
authors: Nagai
authors: Toyonari
authors: T
authors: Kubora
authors: Kanta
authors: K
authors: Jobara
authors: Kosuke
authors: K
authors: Endo
authors: Shinji
authors: S
authors: Uemoto
mesh_terms: D000818:Animals; D003250:Constriction; D006498:Hepatectomy / Q000379:methods*; D006499:Hepatic Artery / Q000601:surgery; D008026:Ligation / Q000379:methods; D008099:Liver / Q000033:anatomy & histology* / Q000098:blood supply; D016031:Liver Transplantation / Q000379:methods*; D023421:Models, Animal; D009929:Organ Size; D011169:Portal Vein / Q000601:surgery; D013552:Swine; D013556:Swine, Miniature