title: [Stevens-Johnson syndrome and Hodgkin's disease: A fortuitous association or paraneoplastic syndrome?].
abstract: BACKGROUND
  Hodgkin's disease has been associated with a variety of cutaneous symptoms. We report two cases of Stevens-Johnson syndrome (SJS) associated with Hodgkin's disease.
  
  
  METHODS
  Case 1: a 22-year-old man was hospitalized for a second erythematous vesicular eruption with intense mucosal involvement. Histopathological examination confirmed the diagnosis of Stevens-Johnson syndrome. He also developed enlarged cervical lymph nodes that revealed Hodgkin's disease. The latter diagnosis was followed by two recurrent rashes. Treatment consisted of systemic chemotherapy. Complete remission was obtained with no signs of cutaneous recurrence after 24 months of regular follow-up. Case 2: a 29-year-old man was admitted for a generalized erythematous and bullous rash with intense mucosal involvement. Histopathological examination confirmed the diagnosis of Stevens-Johnson syndrome. He then developed muco-cutaneous icterus that was secondary to Hodgkin's disease. Under specific hematologic treatment, no cutaneous relapse was noticed.
  
  
  CONCLUSIONS
  These cases illustrate the rare association of SSJ revealing Hodgkin's disease. In these cases, no evidence was found of infectious disease or drug-induced cutaneous effects. Only one case of toxic epidermal necrolysis associated with Hodgkin's disease had previously been reported. The link between both diseases may be immunosuppression induced by Hodgkin's disease, which could favor infection inducing SJS or secretion by tumor cells granulysin, a mediator responsible for damage to keratinocytes.
authors: Service de dermatologie, hôpitaux de Brabois, CHU de Nancy, bâtiment des spécialités médicales Philippe-Canton, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors: A
authors: A
authors: Schoeffler
authors: Service de dermatologie, clinique de dermatologie, hôpital civil, CHU de Strasbourg, 67000 Strasbourg, France.
authors: E
authors: E
authors: Levy
authors: Service de dermatologie, hôpitaux de Brabois, CHU de Nancy, bâtiment des spécialités médicales Philippe-Canton, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors: M
authors: M
authors: Weinborn
authors: Service de dermatologie, hôpitaux de Brabois, CHU de Nancy, bâtiment des spécialités médicales Philippe-Canton, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors: J-F
authors: JF
authors: Cuny
authors: Service de dermatologie, hôpitaux de Brabois, CHU de Nancy, bâtiment des spécialités médicales Philippe-Canton, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors: J-L
authors: JL
authors: Schmutz
authors: Service de dermatologie, hôpitaux de Brabois, CHU de Nancy, bâtiment des spécialités médicales Philippe-Canton, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France.
authors: A
authors: A
authors: Barbaud
authors: Service de dermatologie, clinique de dermatologie, hôpital civil, CHU de Strasbourg, 67000 Strasbourg, France.
authors: B
authors: B
authors: Cribier
authors: Service de dermatologie, hôpitaux de Brabois, CHU de Nancy, bâtiment des spécialités médicales Philippe-Canton, rue du Morvan, 54500 Vandœuvre-lès-Nancy, France. Electronic address: ac.bursztejn@chu-nancy.fr.
authors: A-C
authors: AC
authors: Bursztejn
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D015984:Causality; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006689:Hodgkin Disease / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D012008:Recurrence; D012074:Remission Induction; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology*; D014747:Vinblastine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D001761:Bleomycin; D011344:Procarbazine; D014750:Vincristine; D014747:Vinblastine; D005047:Etoposide; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
keywords: Hodgkin's disease; Maladie de Hodgkin; Recurrent Stevens-Johnson syndrome; Syndrome de Stevens-Johnson récidivant