title: Study on analgesic and anti-inflammatory properties of Cordia myxa fruit hydro-alcoholic extract.
abstract: Cordia myxa is a plant which is used in tropical regions of the world. Analgesic and anti-inflammatory effect of fruit of this medicinal plant was investigated in mice. Hydro-alcoholic extract of it was prepared by maceration method. Formalin test was conducted in six groups of mice (6 animals in each group) and acetic acid test in another six groups (6 mice). Groups one to six in each test were administered normal saline, oral indomethacin, intraperitoneal tramadol, 100 mg kg(-1) oral extract, 200 mg kg(-1) oral extract and 100 mg kg(-1) intraperitoneal extract, respectively. The duration of foot lickings were calculated in formalin- administered (1st) group within min 0 to 5 (acute phase) and 15 to 25 (chronic phase). Acetic acid-induced writhings were counted within 10 min in the 2nd group. The results showed that hydro-alcoholic extract of Cordia myxa fruit was considerably effective in formalin test. Also, analgesic and anti-inflammatory properties of this plant's fruit in both acute and chronic phase are somewhat similar to these properties in the study on animal model of experimental colitis.
authors: Department of Pathobiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.
authors: Mohammadmehdi
authors: M
authors: Ranjbar
authors: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran.
authors: Hossein Najafzadeh
authors: HN
authors: Varzi
authors: Department of Pathobiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran.
authors: Atefeh
authors: A
authors: Sabbagh
authors: Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran.
authors: Adeleh
authors: A
authors: Bolooki
authors: Department of Agriculture, Payame Noor University, Iran.
authors: Alireza
authors: A
authors: Sazmand
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D031213:Cordia / Q000737:chemistry; D004195:Disease Models, Animal; D005260:Female; D005557:Formaldehyde; D005638:Fruit; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D000432:Methanol / Q000737:chemistry*; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D012997:Solvents / Q000737:chemistry*; D014147:Tramadol / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012997:Solvents; D005557:Formaldehyde; D014147:Tramadol; D019342:Acetic Acid; D007213:Indomethacin; D000432:Methanol