title: [Preparation of Sodium Aescinat micro-emulsion for injection].
abstract: OBJECTIVE
  To prepare and optimize the conditions of Sodium Aescinat micro-emulsion for injection.
  
  
  METHODS
  Sodium Aescinat O/W micro-emulsion (soybean phospholipids + HS15/glycerin/medium chain triglycerides/water) was formulated guided by the pseudo-titration ternary phase diagram.
  
  
  RESULTS
  Stable Sodium Aescinat micro-emulsion was obtained with medium chain triglycerides as oil, soybean phospholipids + HS15 (1:2) as emulsifier, glycerin as co-emulsifier, and a ratio of emulsifier and co-emulsifier (Km) between 2.00-3.75.
  
  
  CONCLUSIONS
  Stable Sodium Aescinat micro-emulsion can be prepared with conditions described in this study.
authors: Department of Pharmaceutics, Chongqing Medical University, Chongqing 400016, China.
authors: Zi-Wei
authors: ZW
authors: Li
authors: Department of Pharmaceutics, Chongqing Medical University, Chongqing 400016, China.
authors: Hua
authors: H
authors: Huang
authors: Taiji Group, Chongqing 401147, China.
authors: Yao
authors: Y
authors: Qin
authors: Taiji Group, Chongqing 401147, China.
authors: Kun-Quan
authors: KQ
authors: Xiao
authors: Chongqing Institute of Traditional Chinese Medicine, Key Laboratory of Natural Resources of Chinese Medicinal Materials of Chongqing, Chongqing 400065, China.
authors: Wei-Zao
authors: WZ
authors: Luo
authors: Chongqing Institute of Traditional Chinese Medicine, Key Laboratory of Natural Resources of Chinese Medicinal Materials of Chongqing, Chongqing 400065, China.
authors: Yong
authors: Y
authors: Yang
authors: Department of Medicinal Chemistry, Chengdu Chinese Medicine University, Chengdu 610041, China.
authors: Dan-Dan
authors: DD
authors: Gu
mesh_terms: D002626:Chemistry, Pharmaceutical; D004655:Emulsions / Q000737:chemistry*; D005990:Glycerol; D010743:Phospholipids; D012503:Saponins / Q000737:chemistry*; D014280:Triglycerides; D014315:Triterpenes / Q000737:chemistry*; D014867:Water
chemical_list: D004655:Emulsions; D010743:Phospholipids; D012503:Saponins; D014280:Triglycerides; D014315:Triterpenes; C584713:sodium aescinate; D014867:Water; D005990:Glycerol