title: Topical treatment of onychomycosis as a realistic option to systemic therapy: a case report.
abstract: Onychomycosis is a very common disease, especially in podiatric medical practice. It can be associated with significant patient distress, major disability and pain, and is challenging to treat successfully. This is a case study of a 41-year-old man with distal lateral subungual onychomycosis of 5 years' duration. Forty percent of the great toenail was affected and a total of six toenails were involved. Baseline fungal cultures were positive for Trichophyton rubrum. This patient was treated with efinaconazole 10% solution, a new topical antifungal, once daily for 48 weeks. Mycological cure was noted at the first assessment period (12 weeks), and compete cure was seen at follow-up. This case study alerts physicians to a promising new topical treatment for onychomycosis under development, and to the importance of mycological cure as an early indicator of treatment success.
authors: Aditya K. Gupta, MD, PhD, FAAD, FRCPC, Mediprobe Research Inc, 645 Windemere Road, London, Ontario, Canada. agupta@mediproberesearch.com; agupta@execulink.com.
authors: Aditya K
authors: AK
authors: Gupta
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D014009:Onychomycosis / Q000175:diagnosis / Q000188:drug therapy*; D014230:Triazoles / Q000627:therapeutic use*; D014249:Trichophyton
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C431707:efinaconazole