title: Annexin A11 in disease.
abstract: Ubiquitously expressed in many cell types, annexin A11 (Anxa11) is a member of the multigene family of Ca(2+)-regulated phospholipid-dependent and membrane-binding annexin proteins. Studies have shown that Anxa11 plays an important role in cell division, Ca(2+) signaling, vesicle trafficking and apoptosis. The deregulation and mutation of Anxa11 are involved in systemic autoimmune diseases, sarcoidosis and the development, chemoresistance and recurrence of cancers. Malfunction of Anxa11 may lead to or enhance the metastasis, invasion and drug resistance of cancers through the platelet-derived growth factor receptor (PDGFR) pathway and/or the mitogen-activated protein kinase (MAPK)/p53 pathway. In a variety of diseases, Anxa11 is most commonly reported to function through interactions with apoptosis-linked gene-2 protein (ALG-2) and/or calcyclin (S100A6). Although it has been little studied, Anxa11 is a promising biomarker for the diagnosis, treatment and prognosis of certain diseases. In this review, the associations of Anxa11 with Ca(2+)-regulated exocytosis, cytokinesis, sex differentiation, autoimmune diseases, thrombolysis and cancers are summarized and interpreted.
authors: Department of Biotechnology, Dalian Medical University, Dalian 116044, China.
authors: Jiasheng
authors: J
authors: Wang
authors: Department of Biotechnology, Dalian Medical University, Dalian 116044, China.
authors: Chunmei
authors: C
authors: Guo
authors: Department of Biochemistry, Dalian Medical University, Dalian 116044, China.
authors: Shuqing
authors: S
authors: Liu
authors: Department of Biotechnology, Dalian Medical University, Dalian 116044, China.
authors: Houbao
authors: H
authors: Qi
authors: Department of Biochemistry, Dalian Medical University, Dalian 116044, China.
authors: Yuling
authors: Y
authors: Yin
authors: Department of General Surgery, The Second Hospital of Dalian Medical University, Dalian 116027, China.
authors: Rui
authors: R
authors: Liang
authors: Department of Biotechnology, Dalian Medical University, Dalian 116044, China. Electronic address: mxs288@gmail.com.
authors: Ming-Zhong
authors: MZ
authors: Sun
authors: Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
authors: Frederick T
authors: FT
authors: Greenaway
mesh_terms: D000818:Animals; D017302:Annexins / Q000737:chemistry / Q000378:metabolism* / Q000502:physiology; D048749:Cytokinesis / Q000502:physiology; D004194:Disease; D005089:Exocytosis / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism
chemical_list: D017302:Annexins
keywords: Anxa11; Cancer; Disease; Function