title: Characterization of stress degradation products of fosinopril by using LC-MS/TOF, MS(n) and on-line H/D exchange.
abstract: Fosinopril was subjected to stress degradation studies under hydrolytic (acidic, basic and neutral), oxidative, photolytic and thermal stress conditions. The drug underwent degradation in hydrolytic and photo acidic conditions, while it was stable to oxidative and thermal stress. The degradation products (DPs) were detected after using a gradient LC-MS method. These were characterized using a protocol involving comparison of mass fragmentation pathways of the drug and the DPs, and consideration of mass data generated during MS/TOF, MS(n) and H/D exchange studies. The degradation pathway of the drug was established, which was duly justified by mechanistic explanation.
authors: Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar 160062 Punjab, India.
authors: Mallikarjun
authors: M
authors: Narayanam
authors: Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar 160062 Punjab, India. Electronic address: ssingh@niper.ac.in.
authors: Saranjit
authors: S
authors: Singh
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods; D004355:Drug Stability; D017328:Fosinopril / Q000737:chemistry*; D006868:Hydrolysis; D013058:Mass Spectrometry / Q000379:methods; D010084:Oxidation-Reduction; D010782:Photolysis
chemical_list: D017328:Fosinopril
keywords: Degradation products; Fosinopril; H/D exchange; LC-MS; Stress degradation