title: Optical coherence tomography--near infrared spectroscopy system and catheter for intravascular imaging.
abstract: Owing to its superior resolution, intravascular optical coherence tomography (IVOCT) is a promising tool for imaging the microstructure of coronary artery walls. However, IVOCT does not identify chemicals and molecules in the tissue, which is required for a more complete understanding and accurate diagnosis of coronary disease. Here we present a dual-modality imaging system and catheter that uniquely combines IVOCT with diffuse near-infrared spectroscopy (NIRS) in a single dual-modality imaging device for simultaneous acquisition of microstructural and compositional information. As a proof-of-concept demonstration, the device has been used to visualize co-incident microstructural and spectroscopic information obtained from a diseased cadaver human coronary artery.
authors: Ali M
authors: AM
authors: Fard
authors: Paulino
authors: P
authors: Vacas-Jacques
authors: Ehsan
authors: E
authors: Hamidi
authors: Hao
authors: H
authors: Wang
authors: Robert W
authors: RW
authors: Carruth
authors: Joseph A
authors: JA
authors: Gardecki
authors: Guillermo J
authors: GJ
authors: Tearney
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D002102:Cadaver; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000378:metabolism*; D057510:Endovascular Procedures / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D066298:In Vitro Techniques; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*
chemical_list: D015415:Biomarkers