title: Perilesional enhancement of liver cavernous hemangiomas in magnetic resonance imaging.
abstract: OBJECTIVE
  To evaluate on magnetic resonance imaging (MRI) the occurrence rate of temporal perilesional parenchymal enhancement (PPE) associated with hepatic hemangiomas in a large consecutive series and to determine which aspects are associated with this observation.
  
  
  METHODS
  Institutional review board approved this retrospective study. A computerized search of the MRI database was performed for consecutive patients between January 2008 and January 2012. The study population included 513 liver hemangiomas in 224 patients (104 males and 120 females; mean age of 55.2 ± 13.5 years; age range 24-89 years). Two readers independently reviewed the frequency of PPE, size, speed of enhancement and location of each hemangioma. Marginal models with generalized estimating equation were used. Wald test was applied to verify if the model coefficients were significant.
  
  
  RESULTS
  80/513 (15.6%) hemangiomas showed PPE. The incidence of PPE was significantly higher (p < 0.05) in hemangiomas with Type1 speed of enhancement (51/80, 63.8%) than in those with Type2 or Type3. 66/80 (82.5%) hemangiomas with PPE were subcapsular (p < 0.05). Conversely, the majority (280/433, 64.7%) of hemangiomas without PPE were deep in location (p < 0.001). Lesser proportion of hemangiomas with PPE was located in segment IVa (p < 0.05).
  
  
  CONCLUSIONS
  PPE is not uncommonly seen along with hepatic hemangiomas. This appearance is most frequently observed in rapidly enhancing small lesions with a subcapsular location.
authors: Department of Radiology, Hospital Garcia de Orta, 2801-951, Almada, Portugal.
authors: Marta S C
authors: MS
authors: Sousa
authors: Miguel
authors: M
authors: Ramalho
authors: Vasco
authors: V
authors: Herédia
authors: António P
authors: AP
authors: Matos
authors: João
authors: J
authors: Palas
authors: Yong Hwan
authors: YH
authors: Jeon
authors: Diana
authors: D
authors: Afonso
authors: Richard C
authors: RC
authors: Semelka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006392:Hemangioma, Cavernous / Q000175:diagnosis*; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008536:Meglumine; D008875:Middle Aged; D015588:Observer Variation; D009942:Organometallic Compounds; D015203:Reproducibility of Results; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D008536:Meglumine; C072417:gadoterate meglumine