title: The effect of irrigation of intracisternal papaverine on cerebral blood flow in subarachnoid hemorrhage.
abstract: BACKGROUND
  Despite different treatments, cerebral vasospasm is still the most important cause of death in patients after subarachnoid hemorrhage. This study was conducted to explore the effect of intracisternal washing with papaverine on cerebral blood flow.
  
  
  METHODS
  This study was performed on 40 patients and totally 120 arteries in 2010. Then, variations in cerebral blood flow before and after washing with papaverine were measured and analyzed.
  
  
  RESULTS
  Twenty (20) patients with aneurysm of the anterior communicating artery (ACOM) and 20 patients with aneurysm of the middle cerebral artery (MCA) were assessed. Mean blood flow before aneurysm and before washing in ACOM and MCA was 70.68 ± 14.8 cm/s and 65.66 ± 9.3 cm/s, respectively, which reached 23.25 ± 5.17 cm/s and 34.1 ± 4.7 cm/s, respectively after washing (P value = 0.016 and 0.024). Mean blood flow after aneurysm and before washing in ACOM and MCA was 95.12 ± 13.9 cm/s and 67.44 ± 15.16 cm/s, respectively, which reached 35.69 ± 6.2 cm/s and 38.01 ± 8.28 cm/s, respectively after washing (P value = 0.001 and 0.01).
  
  
  CONCLUSIONS
  Washing with papaverine significantly reduces cerebral blood flow and relieves vasospasm.
authors: Department of Neurosurgery, Al-Zahra Hospital, Isfahan University Of Medical Science, Isfahan, Iran.
authors: Masih
authors: M
authors: Sabouri
authors: Department of Neurosurgery, Al-Zahra Hospital, Isfahan University Of Medical Science, Isfahan, Iran.
authors: Paiman
authors: P
authors: Rahmani
authors: Department of Neurosurgery, Al-Zahra Hospital, Isfahan University Of Medical Science, Isfahan, Iran.
authors: Majid
authors: M
authors: Rezvani
authors: Department of Neurosurgery, Al-Zahra Hospital, Isfahan University Of Medical Science, Isfahan, Iran.
authors: Hossein
authors: H
authors: Nikbakht
authors: Department of Neurosurgery, Al-Zahra Hospital, Isfahan University Of Medical Science, Isfahan, Iran.
authors: Ahmadreza
authors: A
authors: Rafiee
authors: Department of Neurosurgery, Al-Zahra Hospital, Isfahan University Of Medical Science, Isfahan, Iran.
authors: Mostaffa
authors: M
authors: Torkashvand
authors: Department of Neurosurgery, Al-Zahra Hospital, Isfahan University Of Medical Science, Isfahan, Iran.
authors: Noorollah
authors: N
authors: Eshraghi
authors: Department of Neurosurgery, Al-Zahra Hospital, Isfahan University Of Medical Science, Isfahan, Iran.
authors: Nahalossadat
authors: N
authors: Nourian
authors: Department of Neurosurgery, Al-Zahra Hospital, Isfahan University Of Medical Science, Isfahan, Iran.
authors: Mehran
authors: M
authors: Moradi
keywords: Intracisternal washing; papaverine; subarachnoid hemorrhage; vasospasm