title: Association of interleukin 1 family with systemic sclerosis.
abstract: Systemic sclerosis is a connective tissue disease characterized with fibrosis of skin and/or internal organs, and its specific pathological mechanism remains incompletely understood. IL-1 family, whose biological properties are typically pro-inflammatory and pro-fibrosis, has been associated with systemic sclerosis (SSc). Interleukin (IL)-1 family has 11 members, IL-1α, IL-1β, IL-1Ra, IL-18, IL-33, IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-37, and IL-38. With the exception of IL-1Ra and IL-36Ra, each member has its own receptor signal. Abnormal expression of IL-1 and its potential role in the fibrosis process have been probed earliest, as well as its gene polymorphisms with SSc. IL-33 and IL-18 have also been discussed in the recent years, and IL-33 may contribute to the fibrosis of SSc, while IL-18 remains to be researched to confirm its role in fibrosis process. There is a lack of studies on the association of the other members of the IL-1 family, which might provide us the future study area; much more efforts need to be put on this matter.
authors: Medical Genetics Center, Anhui Medical College, Hefei, China.
authors: Li
authors: L
authors: Zhang
authors: Jun-Wei
authors: JW
authors: Yan
authors: Yu-Jie
authors: YJ
authors: Wang
authors: Ya-Nan
authors: YN
authors: Wan
authors: Bing-Xiang
authors: BX
authors: Wang
authors: Jin-Hui
authors: JH
authors: Tao
authors: Bing
authors: B
authors: Chen
authors: Bao-Zhu
authors: BZ
authors: Li
authors: Guo-Jun
authors: GJ
authors: Yang
authors: Jing
authors: J
authors: Wang
mesh_terms: D005355:Fibrosis / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007375:Interleukin-1 / Q000502:physiology*; D020382:Interleukin-18 / Q000502:physiology; D000067596:Interleukin-33; D007378:Interleukins / Q000502:physiology; D005810:Multigene Family; D011110:Polymorphism, Genetic; D012595:Scleroderma, Systemic / Q000378:metabolism*; D015398:Signal Transduction; D012867:Skin / Q000378:metabolism
chemical_list: C000589760:IL18 protein, human; C506536:IL33 protein, human; D007375:Interleukin-1; D020382:Interleukin-18; D000067596:Interleukin-33; D007378:Interleukins