title: Synthesis of Cyclic α-Aminophosphonates through Copper Catalyzed Enamine Activation.
abstract: A copper-catalyzed tandem cyclization triggered addition strategy that relies on electrophilic enamine activation has been used to synthesize various cyclic α-aminophosphonates derivatives in good to excellent yields. Both five and six membered rings can be generated under mild conditions with high regioselectivity. A mechanism based on copper catalyzed enamine activation is proposed.
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
authors: Junbin
authors: J
authors: Han
authors: Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
authors: Robert S
authors: RS
authors: Paton
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
authors: Bo
authors: B
authors: Xu
authors: Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
authors: Gerald B
authors: GB
authors: Hammond
keywords: copper; cyclic α-aminophosphonates; cyclization; enamine; hydroamination