title: Relationship between functional capacity and body mass index with plasma coenzyme Q10 and oxidative damage in community-dwelling elderly-people.
abstract: The impact of aging and physical capacity on coenzyme Q10 (Q10) levels in human blood is unknown. Plasma Q10 is an important factor in cardiovascular diseases. To understand how physical activity in the elderly affects endogenous Q10 levels in blood plasma, we studied a cohort of healthy community-dwelling people. Volunteers were subjected to different tests of the Functional Fitness Test Battery including handgrip strength, six-minute walk, 30 s chair to stand, and time up and go tests. Anthropometric characteristics, plasma Q10 and lipid peroxidation (MDA) levels were determined. Population was divided according to gender and fitness. We found that people showing higher levels of functional capacity presented lower levels of cholesterol and lipid peroxidation accompanied by higher levels of Q10 in plasma. The ratio Q10/cholesterol and Q10/LDL increased in these people. No relationship was found when correlated to muscle strength or agility. On the other hand, obesity was related to lower Q10 and higher MDA levels in plasma affecting women more significantly. Our data demonstrate for the first time that physical activity at advanced age can increase the levels of Q10 and lower the levels of lipid peroxidation in plasma, probably reducing the progression of cardiovascular diseases.
authors: Centro Andaluz de Biología del Desarrollo, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide-CSIC, CIBERER, Instituto de Salud Carlos III, Sevilla, Spain; Departamento de Educación física y Deporte, Universidad de Sevilla, Sevilla, Spain.
authors: Jesús
authors: J
authors: Del Pozo-Cruz
authors: Centro Andaluz de Biología del Desarrollo, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide-CSIC, CIBERER, Instituto de Salud Carlos III, Sevilla, Spain.
authors: Elizabeth
authors: E
authors: Rodríguez-Bies
authors: Centro Andaluz de Biología del Desarrollo, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide-CSIC, CIBERER, Instituto de Salud Carlos III, Sevilla, Spain.
authors: Ignacio
authors: I
authors: Navas-Enamorado
authors: Department of Sport and Exercise Science, University of Auckland, Auckland, New Zealand.
authors: Borja
authors: B
authors: Del Pozo-Cruz
authors: Centro Andaluz de Biología del Desarrollo, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide-CSIC, CIBERER, Instituto de Salud Carlos III, Sevilla, Spain.
authors: Plácido
authors: P
authors: Navas
authors: Centro Andaluz de Biología del Desarrollo, Departamento de Fisiología, Anatomía y Biología Celular, Universidad Pablo de Olavide-CSIC, CIBERER, Instituto de Salud Carlos III, Sevilla, Spain. Electronic address: glopllu@upo.es.
authors: Guillermo
authors: G
authors: López-Lluch
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D009043:Motor Activity; D018384:Oxidative Stress; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014451:Ubiquinone; D002784:Cholesterol; C024989:coenzyme Q10
keywords: Aging; Cardiovascular disease; Coenzyme Q(10); Fitness; Obesity; Physical activity