title: [Correlation of androgen receptor CAG repeats with the risks of benign prostatic hyperplasia and prostate cancer: a meta-analysis].
abstract: OBJECTIVE
  To explore the association of the androgenic receptor (AR) CAG repeats with the risks of benign prostatic hyperplasia (BPH) and prostate cancer (PCa).
  
  
  METHODS
  We searched the major databases at home and abroad for the literature addressing the correlation of the AR gene CAG repeats with BPH and PCa. Based on the results of heterogeneity tests, we used the M-H fixed effect model and random effect model to pool the odds ratio (OR) effect size. We evaluated publication bias by Begg and Egger bias analysis, investigated the association of CAG repeats with the risks of BPH and PCa by systematic review, and stratified their relationship according to the races of the patients.
  
  
  RESULTS
  Based on the selection criteria, 4 of the 29 identified studies were included, with 485 cases of BPH, 767 cases of PCa, and 709 controls. There was no heterogeneity between the BPH and control groups, and no correlation between short CAG repeats and BPH after pooling the odds ratio (OR) effect size. Heterogeneity was found among the BPH, PCa and control groups. Random effects model suggested an association of short CAG repeats with the risk of PCa (OR(PCa/control) = 1.45, OR(PCa/BPH) = 1.86, OR(PCa/(BPH + control)) = 1.66), while subgroup analysis with racial stratification indicated inter-ethnic differences between the two. Begg and Egger bias analysis showed no significant publication bias.
  
  
  CONCLUSIONS
  Shorter CAG repeats are positively correlated with the risk of PCa but not with that of BPH.
authors: Graduate School of Peking Union Medical College, Beijing 100730, China. doctorwxm2013@163.com
authors: Xiao-Ming
authors: XM
authors: Wang
authors: Beijing Institute of Gerontology, Ministry of Health, Beijing 100730, China.
authors: Liang
authors: L
authors: Sun
authors: Beijing Institute of Gerontology, Ministry of Health, Beijing 100730, China.
authors: Zheng
authors: Z
authors: Zhang
authors: Beijing Institute of Gerontology, Ministry of Health, Beijing 100730, China.
authors: Xiao-Hong
authors: XH
authors: Shi
authors: Department of Urology, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors: Yao-Guang
authors: YG
authors: Zhang
authors: Department of Urology, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors: Dong
authors: D
authors: Wei
authors: Department of Urology, Beijing Hospital, Ministry of Health, Beijing 100730, China.
authors: Ben
authors: B
authors: Wan
authors: Beijing Institute of Gerontology, Ministry of Health, Beijing 100730, China.
authors: Ze
authors: Z
authors: Yang
authors: Graduate School of Peking Union Medical College, Beijing 100730, China.
authors: Jian-Ye
authors: JY
authors: Wang
mesh_terms: D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011470:Prostatic Hyperplasia / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D011944:Receptors, Androgen / Q000235:genetics*; D018911:Trinucleotide Repeats
chemical_list: C410798:AR protein, human; D011944:Receptors, Androgen