title: Oxaliplatin induces hypomyelination and reduced neuregulin 1 expression in the rat sciatic nerve.
abstract: Oxaliplatin causes severe peripheral neuropathy. In this study, we examined hypomyelination in the peripheral nerve in oxaliplatin-induced neuropathy rat model. Gene expression of neuregulin 1 (NRG1), a myelination regulatory factor, is reduced in the dorsal root ganglion (DRG) in DNA microarray analysis. Oxaliplatin increased the g-ratio and reduced levels of myelin protein zero in sciatic nerve, suggesting the hypomyelination. Moreover, oxaliplatin reduced NRG1 mRNA levels in the DRG and decreased levels of cleaved NRG1 type III protein in the sciatic nerve. Our results indicate that oxaliplatin induces hypomyelination and reduced NRG1 expression.
authors: Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: k-tsutsu@pahrmst.med.kyushu-u.ac.jp.
authors: Kuniaki
authors: K
authors: Tsutsumi
authors: Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: yamap@pharm.med.kyushu-u.ac.jp.
authors: Yuji
authors: Y
authors: Yamashita
authors: Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: s-ushio@pharmst.med.kyushu-u.ac.jp.
authors: Soichiro
authors: S
authors: Ushio
authors: Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: tkawa@pharm.med.kyushu-u.ac.jp.
authors: Takehiro
authors: T
authors: Kawashiri
authors: Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: 1PS09061T@s.kyushu-u.ac.jp.
authors: Takanori
authors: T
authors: Kaname
authors: Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: ps108075@s.kyushu-u.ac.jp.
authors: Shunsuke
authors: S
authors: Fujita
authors: Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: roishi@med.kyushu-u.ac.jp.
authors: Ryozo
authors: R
authors: Oishi
authors: Department of Pharmacy, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address: n-egashi@pharm.med.kyushu-u.ac.jp.
authors: Nobuaki
authors: N
authors: Egashira
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001369:Axons / Q000473:pathology; D005727:Ganglia, Spinal / Q000187:drug effects / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D009185:Myelin Proteins / Q000235:genetics / Q000378:metabolism; D020890:Neuregulin-1 / Q000235:genetics / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D000077150:Oxaliplatin; D011129:Polyradiculoneuropathy / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D009185:Myelin Proteins; D020890:Neuregulin-1; D009944:Organoplatinum Compounds; D012333:RNA, Messenger; D000077150:Oxaliplatin
keywords: Hypomyelination; Myelin protein zero; Neuregulin; Neuropathy; Oxaliplatin