title: Genotype-phenotype correlations in hepatocellular adenoma: an update of MRI findings.
abstract: Hepatocellular adenoma (HCA) is a generally benign liver tumor with the potential for malignancy and bleeding. HCAs are categorized into four subtypes on the basis of genetic and pathological features: hepatocyte nuclear factor 1α-mutated HCA, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA. Magnetic resonance imaging (MRI) plays an important role in the diagnosis, subtype characterization, and detection of HCA complications; it is also used to differentiate HCA from focal nodular hyperplasia. In this review, we present an overview of the genetic abnormalities, oncogenesis, and typical and atypical MRI findings of specific subtypes of HCA using contrast-enhanced MRI with or without hepatobiliary contrast agents (gadobenate dimeglumine and gadoxetate disodium). We also discuss their different management implications after diagnosis.
authors: From the Departments of Radiology Medical Center Zuiderzee, Lelystad, the Netherlands. m.devries.2@erasmusmc.nl.
authors: Maarten G
authors: MG
authors: Thomeer
authors: Mirelle E
authors: ME
authors: E Bröker
authors: Quido
authors: Q
authors: de Lussanet
authors: Katharina
authors: K
authors: Biermann
authors: Roy S
authors: RS
authors: Dwarkasing
authors: Rob
authors: R
authors: de Man
authors: Jan N
authors: JN
authors: Ijzermans
authors: Marianne
authors: M
authors: de Vries
mesh_terms: D018248:Adenoma, Liver Cell / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis; D005682:Gadolinium; D019786:Gadolinium DTPA; D005838:Genotype; D006801:Humans; D007089:Image Enhancement; D007150:Immunohistochemistry; D008099:Liver / Q000166:cytology / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D055815:Young Adult; D051176:beta Catenin / Q000032:analysis
chemical_list: D003287:Contrast Media; D051176:beta Catenin; C073590:gadolinium ethoxybenzyl DTPA; D005682:Gadolinium; D019786:Gadolinium DTPA