title: Choline chloride-thiourea, a deep eutectic solvent for the production of chitin nanofibers.
abstract: Deep eutectic solvents (DESs) consisting of the mixtures of choline halide (chloride/bromide)-urea and choline chloride-thiourea were used as solvents to prepare α-chitin nanofibers (CNFs). CNFs of diameter 20-30 nm could be obtained using the DESs comprising of the mixture of choline chloride and thiourea (CCT 1:2); however, NFs could not be obtained using the DESs having urea (CCU 1:2) as hydrogen bond donor. The physicochemical properties of thus obtained NFs were compared with those obtained using a couple of imidazolium based ionic liquids namely, 1-butyl-3-methylimidazolium hydrogen sulphate [(Bmim)HSO4] and 1-methylimidazolium hydrogen sulphate [(Hmim)HSO4] as well as choline based bio-ILs namely, choline hydrogen sulphate [(Chol)HSO4] and choline acrylate. The CNFs obtained using the DES as a solvent were used to prepare calcium alginate bio-nanocomposite gel beads having enhanced elasticity in comparison to Ca-alginate beads. The bio-nanocomposite gel beads thus obtained were used to study slow release of 5-fluorouracil, an anticancer drug.
authors: AcSIR - Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364002, Gujarat, India.
authors: Chandrakant
authors: C
authors: Mukesh
authors: AcSIR - Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364002, Gujarat, India.
authors: Dibyendu
authors: D
authors: Mondal
authors: AcSIR - Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364002, Gujarat, India.
authors: Mukesh
authors: M
authors: Sharma
authors: AcSIR - Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364002, Gujarat, India; Marine Biotechnology and Ecology Discipline, CSIR - Central Salt & Marine Chemicals Research Institute, G.B. Marg, Bhavnagar 364002, Gujarat, India. Electronic address: kamlesh@csmcri.org.
authors: Kamalesh
authors: K
authors: Prasad
mesh_terms: D002686:Chitin / Q000138:chemical synthesis* / Q000737:chemistry; D002794:Choline / Q000737:chemistry*; D057139:Nanofibers / Q000737:chemistry*; D010316:Particle Size; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties; D013890:Thiourea / Q000737:chemistry*
chemical_list: D012997:Solvents; D002686:Chitin; D013890:Thiourea; D002794:Choline
keywords: Bio-nanocomposites; Chitin nanofiber; Deepeutectic solvents; Delivery; Drug slow; Ionic liquids