title: [Study on the quality of life and its related factors on patients with multiple myeloma].
abstract: OBJECTIVE
  To evaluate the quality of life and influencing factors on patients with multiple myeloma (MM).
  
  
  METHODS
  227 MM cases were selected at 5 hospitals in Xi'an from August, 2010 to March, 2013. QLQ-C30 was used to evaluate the quality of life of MM patients, and their norms were as control. Factors which influencing the quality of life were investigated and analyzed with SPSS 17.0 software.
  
  
  RESULTS
  The total score of quality of life in MM patients was 49.0±21.7 which was lower than the norms (60.7±23.4). The scores on fatigue, nausea, vomiting, pain, short of breath, disturbance on sleeping, losing appetite, constipation, other symptoms and financial difficulty were significantly higher than data of the norms (P < 0.05). Factors as being elderly (especially those older than 70), under higher proportion of medical costs on their own expense or financial difficulty etc., had major influences on the quality of life (P < 0.05) of MM patients who in particular having worse quality of life when in worsening clinical ISS stage (P < 0.05). Low level of hemoglobin, high level of serum calcium and globulin all significantly reduced the quality of life of the MM patients (P < 0.05).
  
  
  CONCLUSIONS
  The quality of life of MM patients was significantly lower than the normal people or patients with other tumors. Fatigue, pain, and financial difficulty were main influencing factors on the quality of life of MM patients. The assessment on the effects of treatment should relate to the improvement of hemoglobin, serum calcium and globulin, which could all improve the quality of life of MM patients.
authors: Institute of Hematology, Xi'an Central Hospital, Xi'an 710003, China.
authors: Qi-xia
authors: QX
authors: Wang
authors: Department of Epidemiology, School of Preventive Medicine, Fourth Military Medical University. Email: yanyping@fmmu.edu.cn.
authors: Yong-ping
authors: YP
authors: Yan
authors: Department of Epidemiology, School of Preventive Medicine, Fourth Military Medical University.
authors: Zhao-hua
authors: ZH
authors: Ji
authors: Institute of Hematology, Xi'an Central Hospital, Xi'an 710003, China.
authors: Qing-ren
authors: QR
authors: Ni
authors: Institute of Hematology, Xi'an Central Hospital, Xi'an 710003, China.
authors: Yan-ping
authors: YP
authors: Song
authors: Institute of Hematology, Xi'an Central Hospital, Xi'an 710003, China.
authors: Su-tong
authors: ST
authors: Li
authors: Institute of Hematology, Xi'an Central Hospital, Xi'an 710003, China.
authors: Jia
authors: J
authors: Xie
authors: Institute of Hematology, Xi'an Central Hospital, Xi'an 710003, China.
authors: Jing-jing
authors: JJ
authors: Ren
authors: Institute of Hematology, Xi'an Central Hospital, Xi'an 710003, China.
authors: Liang
authors: L
authors: Guo
authors: Institute of Hematology, Xi'an Central Hospital, Xi'an 710003, China.
authors: Jin-qian
authors: JQ
authors: Dai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000453:epidemiology*; D011788:Quality of Life; D011795:Surveys and Questionnaires