title: Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment.
abstract: Heat shock protein 90 (Hsp90) a member of the heat shock proteins (HSPs) family, is an adenosine triphosphate dependent molecular chaperone protein, which integrates multiple oncogenic pathways. Clinically, encouraging results have been demonstrated in melanoma, acute myeloid leukemia, castrate refractory prostate cancer, non-small cell lung carcinoma and multiple myeloma using the first generation Hsp90 inhibitors. Hsp90 as the target of anticancer activity of geldanamycin sparked much interest in the inhibition of Hsp90 as a strategy for the treatment of cancer. Hsp90 inhibitors demonstrate rapid clearance from normal tissues and the blood compartment with prolonged retention in tumors making it a sought after modality for treating cancer. Our review emphasizes its role as anti-cancer therapy for head and neck squamous cell carcinoma.
authors: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
authors: Samapika
authors: S
authors: Routray
authors: Aparajita
authors: A
authors: Sunkavalli
authors: Niharika
authors: N
authors: Swain
authors: Akhil A
authors: AA
authors: Shankar
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D016227:Benzoquinones / Q000494:pharmacology / Q000627:therapeutic use; D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000188:drug therapy*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D047029:Lactams, Macrocyclic / Q000494:pharmacology / Q000627:therapeutic use; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D015398:Signal Transduction; D000077195:Squamous Cell Carcinoma of Head and Neck; D014227:Triazines / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D016227:Benzoquinones; D014408:Biomarkers, Tumor; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D014227:Triazines; C112765:tanespimycin; D011505:Protein-Tyrosine Kinases; D017346:Protein Serine-Threonine Kinases; C001277:geldanamycin