title: Skp2: a dream target in the coming age of cancer therapy.
authors: Department of Molecular and Cellular Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA.
authors: Chia-Hsin
authors: CH
authors: Chan
authors: Department of Experimental Therapeutics; The University of Texas MD Anderson Cancer Center; Houston, TX USA; The University of Texas Graduate School of Biomedical Sciences at Houston; Houston, TX USA.
authors: John Kenneth
authors: JK
authors: Morrow
authors: Department of Experimental Therapeutics; The University of Texas MD Anderson Cancer Center; Houston, TX USA; The University of Texas Graduate School of Biomedical Sciences at Houston; Houston, TX USA.
authors: Shuxing
authors: S
authors: Zhang
authors: Department of Molecular and Cellular Oncology; The University of Texas MD Anderson Cancer Center; Houston, TX USA; The University of Texas Graduate School of Biomedical Sciences at Houston; Houston, TX USA; Graduate Institute of Basic Medical Science; China Medical University; Taichung, Taiwan; Department of Biotechnology; Asia University; Taichung, Taiwan.
authors: Hui-Kuan
authors: HK
authors: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D009369:Neoplasms / Q000201:enzymology*; D014411:Neoplastic Stem Cells / Q000187:drug effects*; D044786:S-Phase Kinase-Associated Proteins / Q000037:antagonists & inhibitors*; D044767:Ubiquitin-Protein Ligases / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D044786:S-Phase Kinase-Associated Proteins; D044767:Ubiquitin-Protein Ligases
keywords: Skp2 inhibitor; cancer stem cells; cancer therapy; cell cycle arrest; glycolysis; in silico modeling; senescence