title: Impaired white-matter integrity in photosensitive epilepsy: a DTI study using tract-based spatial statistics.
abstract: OBJECTIVE
  The present study was designed to map alterations in brain white-matter in photosensitive epilepsy (PSE) by applying tract-based spatial statistics (TBSS) analysis.
  
  
  METHODS
  Diffusion tensor-imaging (DTI) data from MRI brain scans were collected from eight PSE patients and 16 gender- and age-matched non-epileptic controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI scans were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) values in the PSE and control groups were compared using TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement.
  
  
  RESULTS
  Compared with the control subjects, the corpus callosum of PSE patients had significantly lower FA values.
  
  
  CONCLUSIONS
  Our DTI study indicates that white-matter in the corpus callosum was abnormal in PSE patients, and that DTI methods can serve as useful non-invasive tools to evaluate white-matter changes in PSE patients.
authors: Department of Neurosurgery, Jinan Military General Hospital, Jinan 250000, China. Electronic address: duhanjian@gmail.com.
authors: Hanjian
authors: H
authors: Du
authors: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. Electronic address: xiebing6@gmail.com.
authors: Bing
authors: B
authors: Xie
authors: Department of Neurosurgery, Jinan Military General Hospital, Jinan 250000, China. Electronic address: pglu912@126.com.
authors: Peigang
authors: P
authors: Lu
authors: Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. Electronic address: fenghua8888@gmail.com.
authors: Hua
authors: H
authors: Feng
authors: Department of Radiology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China. Electronic address: wangjian881@gmail.com.
authors: Jian
authors: J
authors: Wang
authors: Department of Neurosurgery, Jinan Military General Hospital, Jinan 250000, China. Electronic address: yuanshaoji@qq.com.
authors: Shaoji
authors: S
authors: Yuan
mesh_terms: D000328:Adult; D000465:Algorithms; D003337:Corpus Callosum / Q000473:pathology*; D003627:Data Interpretation, Statistical; D056324:Diffusion Tensor Imaging / Q000379:methods*; D020195:Epilepsy, Reflex / Q000473:pathology*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D010775:Photic Stimulation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D066127:White Matter / Q000473:pathology*; D055815:Young Adult
keywords: DTI; Photosensitive epilepsy; Tract-based spatial statistics; White-matter