title: Regulation of cadherin expression in nervous system development.
abstract: This review addresses our current understanding of the regulatory mechanisms for classical cadherin expression during development of the vertebrate nervous system. The complexity of the spatial and temporal expression patterns is linked to morphogenic and functional roles in the developing nervous system. While the regulatory networks controlling cadherin expression are not well understood, it is likely that the multiple signaling pathways active in the development of particular domains also regulate the specific cadherins expressed at that time and location. With the growing understanding of the broader roles of cadherins in cell-cell adhesion and non-adhesion processes, it is important to understand both the upstream regulation of cadherin expression and the downstream effects of specific cadherins within their cellular context.
authors: Division of Basic Biomedical Sciences; Sanford School of Medicine of The University of South Dakota; Vermillion, SD USA.
authors: Alicia F
authors: AF
authors: Paulson
authors: Department of Molecular Biosciences; Northwestern University; Evanston, IL USA.
authors: Maneeshi S
authors: MS
authors: Prasad
authors: Biology Department; University of South Dakota; Vermillion, SD USA.
authors: Amanda Henke
authors: AH
authors: Thuringer
authors: Division of Basic Biomedical Sciences; Sanford School of Medicine of The University of South Dakota; Vermillion, SD USA.
authors: Pasquale
authors: P
authors: Manzerra
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009420:Nervous System / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D059748:Proteolysis
chemical_list: D015820:Cadherins; D020033:Protein Isoforms
keywords: N-cadherin; cadherin; cadherin-7; neural development; transcriptional regulation