title: Extension of the GATE Monte-Carlo simulation package to model bioluminescence and fluorescence imaging.
abstract: The Geant4 Application for Emission Tomography (GATE) is an advanced open-source software dedicated to Monte-Carlo (MC) simulations in medical imaging involving photon transportation (Positron emission tomography, single photon emission computed tomography, computed tomography) and in particle therapy. In this work, we extend the GATE to support simulations of optical imaging, such as bioluminescence or fluorescence imaging, and validate it against the MC for multilayered media standard simulation tool for biomedical optics in simple geometries. A full simulation set-up for molecular optical imaging (bioluminescence and fluorescence) is implemented in GATE, and images of the light distribution emitted from a phantom demonstrate the relevance of using GATE for optical imaging simulations.
authors: Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, 91401 Orsay, France.
authors: Vesna
authors: V
authors: Cuplov
authors: Laboratoire Imagerie et Modélisation en Neurobiologie et Cancérologie, UMR 8165 CNRS-Université Paris 7-Université Paris 11, France.
authors: Iréne
authors: I
authors: Buvat
authors: Laboratoire Imagerie et Modélisation en Neurobiologie et Cancérologie, UMR 8165 CNRS-Université Paris 7-Université Paris 11, France.
authors: Frédéric
authors: F
authors: Pain
authors: Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, 91401 Orsay, France.
authors: Sébastien
authors: S
authors: Jan
mesh_terms: D003198:Computer Simulation; D008954:Models, Biological; D009010:Monte Carlo Method; D061848:Optical Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012984:Software; D014054:Tomography / Q000379:methods*