title: Femtosecond Laser-Assisted Intra-Corneal Drug Delivery.
abstract: OBJECTIVE
  To present a case of fungal keratitis that was successfully treated with direct intrastromal medication delivery through a corneal incision created with the femtosecond laser.
  
  
  METHODS
  A 71-year-old female patient with recurrent episodes of an unresponsive, deep stromal keratitis for six months' duration, resistant to various therapeutic approaches, was referred to our institute. The 150 kHz Intralase iFS laser (Abbott Medical Optics Inc., Santa Ana, CA) was used to create a corneal pocket in an attempt to permit drug delivery directly into the corneal abscess.
  
  
  RESULTS
  Five days after the intrastromal injections, the clinical condition was improved. Two years after the procedure, the cornea is stable and free of any clinical signs or symptoms of recurrence.
  
  
  CONCLUSIONS
  In this case report, an alternative application of femtosecond laser technology is presented, performing intrastromal drug delivery through a corneal incision for the treatment of fungal keratitis.
authors: a Institute of Vision and Optics, University of Crete , Greece and.
authors: Ioannis G
authors: IG
authors: Pallikaris
authors: a Institute of Vision and Optics, University of Crete , Greece and.
authors: George D
authors: GD
authors: Kymionis
authors: a Institute of Vision and Optics, University of Crete , Greece and.
authors: Argyro D
authors: AD
authors: Plaka
authors: b Gordon Binder Vision Institute , San Diego , California , USA.
authors: Perry S
authors: PS
authors: Binder
authors: a Institute of Vision and Optics, University of Crete , Greece and.
authors: Georgios A
authors: GA
authors: Kontadakis
authors: a Institute of Vision and Optics, University of Crete , Greece and.
authors: Konstantinos I
authors: KI
authors: Tsoulnaras
mesh_terms: D000038:Abscess / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D003319:Corneal Stroma / Q000601:surgery; D048988:Corneal Surgery, Laser / Q000379:methods*; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D016503:Drug Delivery Systems; D004343:Drug Implants; D004359:Drug Therapy, Combination; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage; D006801:Humans; D054018:Lasers, Excimer / Q000627:therapeutic use; D000077266:Moxifloxacin; D065819:Voriconazole / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004343:Drug Implants; D024841:Fluoroquinolones; D065819:Voriconazole; D000077266:Moxifloxacin
keywords: Corneal abscess; femtosecond laser; fungus; intracorneal drug; keratitis