title: Emerging roles of hematopoietic cells in the pathobiology of diabetic complications.
abstract: Diabetic complications encompass macrovascular events, mainly the result of accelerated atherosclerosis, and microvascular events that strike the eye (retinopathy), kidney (nephropathy), and nervous system (neuropathy). The traditional view is that hyperglycemia-induced dysregulated biochemical pathways cause injury and death of cells intrinsic to the organs affected. There is emerging evidence that diabetes compromises the function of the bone marrow (BM), producing a stem cell niche-dependent defect in hematopoietic stem cell mobilization. Furthermore, dysfunctional BM-derived hematopoietic cells contribute to diabetic complications. Thus, BM cells are not only a victim but also an accomplice in diabetes and diabetic complications. Understanding the underlying molecular mechanisms may lead to the development of new therapies to prevent and/or treat diabetic complications by specifically targeting these perpetrators.
authors: Departments of Medicine and Molecular and Cellular Biology, and the Diabetes and Endocrinology Research Center, Baylor College of Medicine, Houston, Texas 77030, USA; Department of Stem Cell Biology and Regenerative Medicine, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.
authors: Hideto
authors: H
authors: Kojima
authors: Departments of Medicine and Molecular and Cellular Biology, and the Diabetes and Endocrinology Research Center, Baylor College of Medicine, Houston, Texas 77030, USA.
authors: Jongoh
authors: J
authors: Kim
authors: Departments of Medicine and Molecular and Cellular Biology, and the Diabetes and Endocrinology Research Center, Baylor College of Medicine, Houston, Texas 77030, USA. Electronic address: lchan@bcm.edu.
authors: Lawrence
authors: L
authors: Chan
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology* / Q000503:physiopathology; D048909:Diabetes Complications / Q000473:pathology* / Q000503:physiopathology*; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D006943:Hyperglycemia / Q000473:pathology / Q000503:physiopathology
keywords: bone marrow; complications; diabetes mellitus; diabetic nephropathy; diabetic neuropathy; diabetic retinopathy; hematopoietic cells