title: [Association of resistin gene 3'UTR+62G>A polymorphism with insulin resistance, adiposity and the adiponectin-resistin index in Mexican population].
abstract: BACKGROUND
  Insulin resistance (IR) is a disease with genetic susceptibility characterized by the increase in storage and irregular body fat distribution, and impaired production of adipokines.
  
  
  OBJECTIVE
  The objective was to investigate the relationship between 3'UTR+62G>A RETN gene polymorphism, with adiponectin-resistin index (ARindex), adiposity, and inmuno-metabolic markers.
  
  
  METHODS
  In this cross-sectional study, 260 individuals characterized as Mexican-Mestizo and classified in lean and overweight, and IR and without-IR, were included. Anthropometrics, body composition, body fat distribution and inflammation and metabolic markers were measured by routine methods, RETN 3'UTR+62G>A alleles were identified by PCR-RFLP and soluble insulin, total adiponectin and resistin were measured by ELISA methods.
  
  
  RESULTS
  The +62G allele frequencies for lean and overweight individuals were different P=0.0343 (95.4% and 98.4%, respectively). The lean GA genotype carriers showed significant low measures of ARindex, adiposity, and inmuno-metabolic markers, than the GG genotype carriers. We found differences between individuals with IR and without-IR: in ARindex (P=0.002), adiponectin (P=0.002) and resistin levels (P=0.033): 1.102 ± 0.03, 5.167 ± 0.36 ug/mL and 8.827 ± 0.42 ng/mL versus 1.336 ± 0.07, 3.577 ± 0.34 ug/mL and 10.480 ± 0.65 ng/mL. Showed correlations with inflammation markers, distribution and body fat storage (r=0.262 to 0.414), P< 0.05.
  
  
  CONCLUSIONS
  The present data suggest that in a Mexican-mestizo population the RETN +62G>A polymorphism is associated with overweight. The presence of the +62A allele was associated with increase of total adiponectin, ARindex, resistin levels, metabolic markers and body fat storage. ARindex can be an early indicator of insulin resistance.
authors: Doctorado en Ciencias Biomédicas. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. Jalisco. México.. rosa_elena_n@hotmail.com.
authors: Efraín
authors: E
authors: Chavarria-Ávila
authors: Departamento de Farmacobiología. Centro Universitario de Ciencias Exactas e Ingenierías. Universidad de Guadalajara- Jalisco. México..
authors: Sandra Luz
authors: SL
authors: Ruíz Quezada
authors: Doctorado en Ciencias Biomédicas. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. Jalisco. México..
authors: Milton-Omar
authors: MO
authors: Guzmán-Ornelas
authors: Maestría en Nutrición Humana. Universidad de Guadalajara. Jalisco. México. H. M. I. E.L.M., Secretaría de Salud Jalisco. Guadalajara. Jalisco. México..
authors: Jorge
authors: J
authors: Castro-Albarrán
authors: Doctorado en Ciencias Biomédicas. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. Jalisco. México. Departamento de Salud Pública. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. Jalisco. México..
authors: Maria Elena
authors: ME
authors: Aguilar Aldrete
authors: Doctorado en Ciencias Biomédicas. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. Jalisco. México. Departamento de Biología Molecular y Genómica. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. Jalisco. México..
authors: Mónica
authors: M
authors: Vásquez-Del Mercado
authors: Doctorado en Ciencias Biomédicas. Centro Universitario de Ciencias de la Salud. Universidad de Guadalajara. Jalisco. México. Maestría en Nutrición Humana. Universidad de Guadalajara. Jalisco. México.. rosa_elena_n@hotmail.com.
authors: Rosa-Elena
authors: RE
authors: Navarro-Hernández
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics*; D052242:Adiponectin / Q000097:blood*; D050154:Adiposity / Q000235:genetics*; D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007197:Indians, Central American; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D052243:Resistin / Q000097:blood / Q000235:genetics*; D055815:Young Adult
chemical_list: D020413:3' Untranslated Regions; D052242:Adiponectin; D052243:Resistin