title: Combination therapy with dexamethasone intravitreal implant and macular grid laser in patients with branch retinal vein occlusion.
abstract: OBJECTIVE
  To test a combination of dexamethasone intravitreal implant with macular grid laser for macular edema in patients with branch retinal vein occlusion (BRVO).
  
  
  METHODS
  Prospective interventional, randomized, multicenter study.
  
  
  METHODS
  Patients with macular edema secondary to BRVO underwent an Ozurdex intravitreal implant at baseline. After 1 month, patients were randomly assigned to 2 study groups. Patients in Group 1 were followed up monthly and retreated with Ozurdex implant whenever there was a recurrence of macular edema or a decrease in best-corrected visual acuity (BCVA). In Group 2 patients macular grid laser was performed between weeks 6 and 8. After that, patients were followed up and retreated as for Group 1.
  
  
  RESULTS
  In Group 1 at 4 months, mean BCVA was 0.49 ± 0.35 logMAR and central retinal thickness (CRT) was 391 ± 172 μm; both improved significantly at 6 months, to 0.32 ± 0.29 logMAR and 322 ± 160 μm, respectively. In Group 2, CRT was reduced significantly to 291 ± 76 μm at 4 months, and BCVA improved to 0.25 ± 0.20 logMAR. At the final visit, BCVA was 0.18 ± 0.14 logMAR and mean CRT was 271 ± 44 μm. The number of Ozurdex implants at 4 months was 12 of 25 (48%) in Group 1 patients vs 3 of 25 (12%) in Group 2 patients (P = .012). At 6 months 3 of 25 patients (12%) in Group 1 vs 0 of 25 (0%) in Group 2 (P = .23) were retreated.
  
  
  CONCLUSIONS
  The combination of Ozurdex implant and macular grid laser is synergistic in increasing BCVA and lengthening the time between injections.
authors: San Giuseppe Hospital, University Eye Clinic, Milan, Italy. Electronic address: ilmiticopicchio@gmail.com.
authors: Francesco
authors: F
authors: Pichi
authors: Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
authors: Claudia
authors: C
authors: Specchia
authors: San Giuseppe Hospital, University Eye Clinic, Milan, Italy.
authors: Lucia
authors: L
authors: Vitale
authors: San Giuseppe Hospital, University Eye Clinic, Milan, Italy.
authors: Andrea
authors: A
authors: Lembo
authors: Sant'Orsola-Malpighi Hospital, Ophthalmology Unit, Bologna, Italy.
authors: Mariachiara
authors: M
authors: Morara
authors: Sant'Orsola-Malpighi Hospital, Ophthalmology Unit, Bologna, Italy.
authors: Chiara
authors: C
authors: Veronese
authors: Sant'Orsola-Malpighi Hospital, Ophthalmology Unit, Bologna, Italy.
authors: Antonio P
authors: AP
authors: Ciardella
authors: San Giuseppe Hospital, University Eye Clinic, Milan, Italy.
authors: Paolo
authors: P
authors: Nucci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D003907:Dexamethasone / Q000008:administration & dosage*; D004343:Drug Implants; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D017075:Laser Coagulation; D054023:Lasers, Semiconductor; D008269:Macular Edema / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012170:Retinal Vein Occlusion / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014822:Vitreous Body
chemical_list: D004343:Drug Implants; D005938:Glucocorticoids; D003907:Dexamethasone