title: Interventional digital tomosynthesis from a standard fluoroscopy system using 2D-3D registration.
abstract: Fluoroscopy is the mainstay of interventional radiology. However, the images are 2D and visualisation of vasculature requires nephrotoxic contrast. Cone-beam computed tomography is often available, but involves large radiation dose and interruption to clinical workflow. We propose the use of 2D-3D image registration to allow digital tomosynthesis (DTS) slices to be produced using standard fluoroscopy equipment. Our method automatically produces patient-anatomy-specific slices and removes clutter resulting from bones. Such slices could provide additional intraoperative information, offering improved guidance precision. Image acquisition would fit with interventional clinical workflow and would not require a high x-ray dose. Phantom results showed a 1133% contrast-to-noise improvement compared to standard fluoroscopy. Patient results showed our method enabled visualisation of clinically relevant features: outline of the aorta, the aortic bifurcation and some aortic calcifications.
authors: Biomedical Engineering Dept., King's College London, London, UK.
authors: Mazen
authors: M
authors: Alhrishy
authors: Biomedical Engineering Dept., King's College London, London, UK.
authors: Andreas
authors: A
authors: Varnavas
authors: Vascular Surgery Dept., Guys & St Thomas' NHS Foundation Trust, London, UK.
authors: Tom
authors: T
authors: Carrell
authors: Biomedical Engineering Dept., King's College London, London, UK.
authors: Andrew
authors: A
authors: King
authors: Biomedical Engineering Dept., King's College London, London, UK.
authors: Graeme
authors: G
authors: Penney
mesh_terms: D000465:Algorithms; D005471:Fluoroscopy / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D019047:Phantoms, Imaging; D011856:Radiographic Image Enhancement / Q000295:instrumentation / Q000379:methods*; D015641:Radiography, Interventional / Q000295:instrumentation / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*