title: Clinical importance of mean platelet volume in children with nephrotic syndrome.
abstract: OBJECTIVE
  The importance of changes about platelet emphasized in most chronically diseases in recent years. Mean platelet volume (MPV) and platelet count can be used as a prognostic biomarker. In this study, clinical importance of the changes of MPV during active and remission phases in children with nephrotic syndrome was investigated.
  
  
  METHODS
  Fifty-five children with nephrotic syndrome (30 females, 25 males) and 29 healthy children (18 females, 11 males) were included to the study. Patients were divided in two groups (steroid sensitive nephrotic syndrome and focal segmental glomerulosclerosis). Demographic characteristics of the patients, type of nephrotic syndrome were recorded and laboratory parameters in active and remission phases were evaluated.
  
  
  RESULTS
  Mean platelet count in the patient group was significantly higher than control group. Mean platelet count of FSGS group was significantly higher than SSNS group. Mean MPV value was significantly lower in active period of nephrotic syndrome when compared with control group. A significant negative relation between mean MPV value and mean platelet count was found. Significant positive correlations between mean platelet count and mean total cholesterol and mean triglyceride levels were demonstrated.
  
  
  CONCLUSIONS
  MPV in nephrotic syndrome patients can be an easy, cheap and simple method for determine the prognosis of the disease and steroid resistance.
authors: Pediatric Nephrology Department, Baskent University , Ankara , Turkey and.
authors: Kaan
authors: K
authors: Gulleroglu
authors: Baris
authors: B
authors: Yazar
authors: Hale
authors: H
authors: Sakalli
authors: Handan
authors: H
authors: Ozdemir
authors: Esra
authors: E
authors: Baskin
mesh_terms: D000293:Adolescent; D015415:Biomarkers; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D009404:Nephrotic Syndrome / Q000097:blood* / Q000175:diagnosis; D011379:Prognosis
chemical_list: D015415:Biomarkers
keywords: Focal segmental glomerulosclerosis; mean platelet volume; nephrotic syndrome; prognostic biomarker; steroid resistance