title: Highly stereoselective generation of complex oxy-bicyclic scaffolds via an atom-economic Pd(II)-catalyzed hydroalkynylation, isomerization and Diels-Alder cycloaddition sequence.
abstract: An atom-economic tandem Pd(II)-catalyzed hydroalkynylation, alkyne-allene isomerization, and Diels-Alder cycloaddition is reported. The reaction employs readily available starting substrates, proceeds in a highly ordered fashion, features high regio- and stereoselectivity, and tolerates a wide range of functionality and structural motifs, thus offering an attractive strategy for producing new molecular complexity and diversity from easily available starting materials. A mechanistic study with density functional theoretical calculations was conducted to rationalize the observed stereoselectivity.
authors: State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing Tech University , Nanjing 210009, P. R. China.
authors: Ruwei
authors: R
authors: Shen
authors: Ke
authors: K
authors: Chen
authors: Qiulin
authors: Q
authors: Deng
authors: Jianjun
authors: J
authors: Yang
authors: Lixiong
authors: L
authors: Zhang