title: Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury.
abstract: Peripheral neuropathies are heterogeneous disorders presenting often with hyperalgesia and allodynia. This study has assessed if chronic constriction injury (CCI) of sciatic nerve is accompanied by increased oxidative stress and central nervous system (CNS) changes and if these changes are sensitive to treatment with thioctic acid. Thioctic acid is a naturally occurring antioxidant existing in two optical isomers (+)- and (-)-thioctic acid and in the racemic form. It has been proposed for treating disorders associated with increased oxidative stress. Sciatic nerve CCI was made in spontaneously hypertensive rats (SHRs) and in normotensive reference cohorts. Rats were untreated or treated intraperitoneally for 14 days with (+/-)-, (+)-, or (-)-thioctic acid. Oxidative stress, astrogliosis, myelin sheets status, and neuronal injury in motor and sensory cerebrocortical areas were assessed. Increase of oxidative stress markers, astrogliosis, and neuronal damage accompanied by a decreased expression of neurofilament were observed in SHR. This phenomenon was more pronounced after CCI. Thioctic acid countered astrogliosis and neuronal damage, (+)-thioctic acid being more active than (+/-)- or (-)-enantiomers. These findings suggest a neuroprotective activity of thioctic acid on CNS lesions consequent to CCI and that the compound may represent a therapeutic option for entrapment neuropathies.
authors: School of Bioscience and Biotechnology, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy.
authors: Daniele
authors: 0000-0001-9062-3305
authors: D
authors: Tomassoni
authors: School of Medicinal and Health Products Sciences, University of Camerino, Via Madonna delle Carceri, 9, 62032 Camerino, Italy.
authors: Francesco
authors: 0000-0002-7794-4662
authors: F
authors: Amenta
authors: Department of Clinical and Preclinical Pharmacology, University of Florence, Viale Pieraccini, 6, 50134 Florence, Italy.
authors: Lorenzo
authors: 0000-0001-8374-4432
authors: L
authors: Di Cesare Mannelli
authors: Department of Clinical and Preclinical Pharmacology, University of Florence, Viale Pieraccini, 6, 50134 Florence, Italy.
authors: Carla
authors: C
authors: Ghelardini
authors: School of Medicinal and Health Products Sciences, University of Camerino, Via Madonna delle Carceri, 9, 62032 Camerino, Italy.
authors: Innocent E
authors: IE
authors: Nwankwo
authors: Department of Anatomy, Histology and Forensic Medicine, University of Florence, Largo Brambilla, 1, 50134 Florence, Italy.
authors: Alessandra
authors: A
authors: Pacini
authors: School of Medicinal and Health Products Sciences, University of Camerino, Via Madonna delle Carceri, 9, 62032 Camerino, Italy.
authors: Seyed Khosrow
authors: 0000-0002-7219-6917
authors: SK
authors: Tayebati
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism; D002490:Central Nervous System / Q000187:drug effects*; D006801:Humans; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D018384:Oxidative Stress / Q000187:drug effects; D059348:Peripheral Nerve Injuries / Q000188:drug therapy* / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy / Q000473:pathology; D051381:Rats; D011918:Rats, Inbred SHR; D012584:Sciatic Nerve / Q000187:drug effects / Q000473:pathology; D008063:Thioctic Acid / Q000008:administration & dosage*
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D008063:Thioctic Acid