title: Development of cellulosic polymer based gel of novel ternary mixture of miconazole nitrate for buccal delivery.
abstract: Aim of the present investigation was to develop cellulosic polymer based mucoadhesive antifungal gel comprising novel ternary mixture of miconazole nitrate (MN) for buccal delivery. Crosslinking of gel was made by adjusting pH with triethanolamine (TEA) and gel formulation was optimized on the basis of flux of MN (0.562-1.751 mg/cm(2)/h) calculated from ex vivo permeation study. Based on statistically validated polynomial equation and plotted response surfaces, B17 was found to be the optimum batch. Texture profile in terms of adhesiveness (3.24 ± 0.012 g), firmness (10.83 ± 0.067 g), spreadability (3.63 ± 0.033 mJ) and extrudability (35.6 ± 0.1 mJ) of B17 was evaluated using a novel instrumental approach. The texture parameters were found to be consistent over 90 days. Ternary mixture containing gel showed broader zone of growth inhibition (32.67-47.33 mm) in comparison to marketed formulation containing pure MN (17.50-40.33 mm) against selected strains of fungi. In conclusion, consistent and effective mucoadhesive antifungal gel of MN with extended residence time in oral mucosa was developed.
authors: Herbal Medicinal Products Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), P.O. CIMAP, Lucknow, U.P. 226015, India.
authors: Vineet Kumar
authors: VK
authors: Rai
authors: Herbal Medicinal Products Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), P.O. CIMAP, Lucknow, U.P. 226015, India. Electronic address: npyadav@gmail.com.
authors: Narayan Prasad
authors: NP
authors: Yadav
authors: Herbal Medicinal Products Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), P.O. CIMAP, Lucknow, U.P. 226015, India.
authors: Priyam
authors: P
authors: Sinha
authors: Herbal Medicinal Products Department, CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), P.O. CIMAP, Lucknow, U.P. 226015, India.
authors: Nidhi
authors: N
authors: Mishra
authors: Molecular Bio-prospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, P. O. CIMAP, Lucknow, U.P. 226015, India.
authors: Suaib
authors: S
authors: Luqman
authors: Department of Pharmaceutics, Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Faizabad Road, Lucknow, U.P. 227105, India.
authors: Harinath
authors: H
authors: Dwivedi
authors: Department of Pharmaceutics, Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management, Faizabad Road, Lucknow, U.P. 227105, India.
authors: Koshy M
authors: KM
authors: Kymonil
authors: Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, U.P. 226025, India. Electronic address: shubhini.saraf@gmail.com.
authors: Shubhini A
authors: SA
authors: Saraf
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002482:Cellulose / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D005782:Gels / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008825:Miconazole / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013175:Sporothrix / Q000187:drug effects; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D005782:Gels; D011108:Polymers; D008825:Miconazole; D002482:Cellulose
keywords: Buccal delivery; Ex vivo permeation; Miconazole nitrate; Mucoadhesive antifungal gel; Ternary mixture; Texture analysis