title: The impact of unilateral versus bilateral antegrade cerebral perfusion on surgical outcomes after aortic arch replacement: a propensity-matched analysis.
abstract: OBJECTIVE
  Antegrade cerebral perfusion during mild systemic hypothermia has been successfully used in aortic arch surgery. Whether bilateral antegrade cerebral perfusion is more neuroprotective then unilateral antegrade cerebral perfusion has been the subject of much debate.
  
  
  METHODS
  Between 2000 and 2012, 1097 patients underwent aortic arch replacement using 28°C to 30°C antegrade cerebral perfusion perfusate during mild systemic hypothermia in a pressure-controlled manner (≥70 mm Hg). After excluding acute type A dissections, 738 elective surgeries with unilateral (n = 477) or bilateral (n = 261) antegrade cerebral perfusion underwent logistic regression analysis with covariates among 9 patient variables (age, coronary disease, diabetes, renal failure, stroke, antegrade cerebral perfusion time, partial vs total arch replacement, aortic valve replacement, and cardiopulmonary bypass time). By using the significant regression coefficients, each patient's propensity score was calculated, allowing selectively matched subgroups of 246 patients each. Operative outcomes were analyzed for differences.
  
  
  RESULTS
  There was no significant difference between unilateral and bilateral antegrade cerebral perfusion groups in early mortality (9/246:4% vs 11/246:4%; P = .8) and transient neurologic deficits (12/246:5% vs 10/246:4%; P = .8). A trend toward a higher incidence of stroke with bilateral antegrade cerebral perfusion (5/246:2% vs 14/246:6%; P = .06) was observed. Similar results regarding transient neurologic deficits (6/91:7% vs 5/93:5%; P = .7) and the incidence of stroke (2/91:3% vs 9/93:9%; P = .06) were observed in matched patients with total arch replacement only.
  
  
  CONCLUSIONS
  Using unilateral antegrade cerebral perfusion in a pressure-controlled manner during mild systemic hypothermia is a safe protection strategy in elective aortic arch surgery, associated with similar morbidity and mortality in comparison with bilateral antegrade cerebral perfusion, even if total arch replacement is required. Bilateral antegrade cerebral perfusion reveals a trend of higher incidence of stroke, probably due to manipulation on the arch vessels.
authors: Division of Thoracic and Cardiovascular Surgery, Johann-Wolfgang-Goethe University Frankfurt/Main, Frankfurt Main, Germany. Electronic address: andreas.zierer@kgu.de.
authors: Andreas
authors: A
authors: Zierer
authors: Division of Thoracic and Cardiovascular Surgery, Johann-Wolfgang-Goethe University Frankfurt/Main, Frankfurt Main, Germany.
authors: Petar
authors: P
authors: Risteski
authors: Division of Thoracic and Cardiovascular Surgery, Johann-Wolfgang-Goethe University Frankfurt/Main, Frankfurt Main, Germany.
authors: Ali
authors: A
authors: El-Sayed Ahmad
authors: Division of Thoracic and Cardiovascular Surgery, Johann-Wolfgang-Goethe University Frankfurt/Main, Frankfurt Main, Germany.
authors: Anton
authors: A
authors: Moritz
authors: Cardiovascular Clinic Bad Neustadt, Bad Neustadt, Germany.
authors: Anno
authors: A
authors: Diegeler
authors: Cardiovascular Clinic Bad Neustadt, Bad Neustadt, Germany.
authors: Paul P
authors: PP
authors: Urbanski
mesh_terms: D000368:Aged; D001013:Aorta, Thoracic / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D010477:Perfusion / Q000379:methods*; D057216:Propensity Score; D011446:Prospective Studies; D016896:Treatment Outcome