title: Reversible mechanisms of enzyme inhibition and resulting clinical significance.
abstract: Inhibition of a drug-metabolizing enzyme by the reversible interaction of a drug with the enzyme, thus decreasing the metabolism of another drug, is a major cause of clinically significant drug-drug interactions. This chapter defines the four reversible mechanisms of inhibition exhibited by drugs: competitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a reversible inhibitor is also provided. Finally, a number of examples of clinically significant drug-drug interactions resulting from reversible inhibition are described.
authors: Quintiles, 5225 Exploration Drive, Indianapolis, IN, 46241, USA.
authors: Barbara
authors: B
authors: Ring
authors: Steven A
authors: SA
authors: Wrighton
authors: Michael
authors: M
authors: Mohutsky
mesh_terms: D001667:Binding, Competitive; D004353:Drug Evaluation, Preclinical; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D004798:Enzymes; D004364:Pharmaceutical Preparations