title: Treatment of canine asthma by high selective vagotomy.
abstract: OBJECTIVE
  This study evaluated the effect of high selective bilateral vagotomy of hilus pulmonis with video-assisted thoracoscopy on asthma.
  
  
  METHODS
  Eight dogs with skin sensitive to Ascaris suum antigens were randomly divided into groups A and B. Asthma was induced by aerosol inhalation of A suum antigens. Respiratory rate and peak airway pressure were significantly increased (P < .05) in both groups. Dynamic compliance was dramatically increased (P < .05) in both groups. Two days later, bilateral vagotomy of hilus pulmonis under thoracoscopic guidance was performed on dogs in group A; dogs in group B underwent bilateral sham vagotomy plus thoracoscopy. Five days after treatment, all dogs had rechallenge with a second aerosol inhalation.
  
  
  RESULTS
  Dogs in group A did not show typical asthmatic symptoms, and no significant changes were found in respiratory rate, peak airway pressure, and dynamic compliance (P > .05). Dogs in group B still had typical symptoms, and respiratory rate and peak airway pressure were increased and dynamic compliance decreased significantly (P < .05 for all). Significant differences in respiratory rate, peak airway pressure, and dynamic compliance were observed between groups. Moreover, inflammatory cells in the lungs and bronchoalveolar lavage fluid of group A were dramatically reduced relative to group B (P < .05). There were no significant changes in heart rate and mean arterial pressure after vagotomy, indicating that vagotomy did not affect the cardiac plexus of vagus.
  
  
  CONCLUSIONS
  High selective bilateral vagotomy of hilus pulmonis with thoracoscope can effectively control asthma in dogs.
authors: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Rui
authors: R
authors: Liu
authors: State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors: Jiangping
authors: J
authors: Song
authors: Department of Cardiothoracic Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Hui
authors: H
authors: Li
authors: Department of Cardiothoracic Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Ziheng
authors: Z
authors: Wu
authors: Department of Cardiothoracic Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Huiguo
authors: H
authors: Chen
authors: Department of Cardiothoracic Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
authors: Weibin
authors: W
authors: Wu
authors: Department of Cardiothoracic Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address: Liurui009181@163.com.
authors: Lijia
authors: L
authors: Gu
mesh_terms: D000336:Aerosols; D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology; D017165:Ascaris suum / Q000276:immunology; D001249:Asthma / Q000097:blood / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000276:immunology / Q000503:physiopathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004285:Dogs; D018836:Inflammation Mediators / Q000097:blood; D019570:Inhalation Exposure; D008168:Lung / Q000276:immunology / Q000294:innervation*; D008170:Lung Compliance; D011312:Pressure; D056152:Respiratory Rate; D020775:Thoracic Surgery, Video-Assisted; D013990:Tidal Volume; D013997:Time Factors; D014628:Vagotomy / Q000379:methods*
chemical_list: D000336:Aerosols; D000947:Antigens, Helminth; D018836:Inflammation Mediators