title: The emerging biomolecular role of vitamin D in skeletal muscle.
abstract: In this review, we summarize current evidence for a direct effect of vitamin D on skeletal muscle. A number of studies identify the receptor for 1,25-dihydroxyvitamin-D3 (vitamin D receptor (VDR)) and the enzyme CYP27B1 (1-α-hydroxylase) in muscle. We hypothesize that vitamin D acts on myocytes via the VDR, and we examine proposed effects on myocyte proliferation, differentiation, growth, and inflammation.
authors: 1Nutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University; 2Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center; and 3Bone Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
authors: Rachele M
authors: RM
authors: Pojednic
authors: Lisa
authors: L
authors: Ceglia
mesh_terms: D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D006801:Humans; D032342:Muscle Cells / Q000166:cytology; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D018167:Receptors, Calcitriol / Q000302:isolation & purification / Q000378:metabolism*; D014807:Vitamin D / Q000378:metabolism*
chemical_list: D018167:Receptors, Calcitriol; D014807:Vitamin D; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase