title: Mutant enzymes challenge all assumptions.
abstract: Enzymes called Rab GTPases that carry so-called "activating" mutations may never become activated at all.
authors: Ryan M Nottingham is in the Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, United States ryan.nottingham@utexas.edu.
authors: Ryan M
authors: RM
authors: Nottingham
authors: Suzanne R
authors: SR
authors: Pfeffer
mesh_terms: D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism*; D006801:Humans; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
chemical_list: D020662:Guanine Nucleotide Exchange Factors; D020691:rab GTP-Binding Proteins
keywords: Membrane traffic; Rab GTPase; nucleotide exchange factor