title: Modulators of the nuclear receptor retinoic acid receptor-related orphan receptor-γ (RORγ or RORc).
abstract: As the biology surrounding the nuclear receptor retinoic acid receptor-related orphan receptor-gamma (RORγ or RORc) continues to evolve, significant effort has been invested in discovering modulators of this potentially important target for the treatment of metabolic and immunological diseases. Several major pharmaceutical and biotechnology companies have disclosed RORc inhibitors or partnered with other players in the field. In this perspective, we discuss both the biology and the underlying structural biology of RORc, and summarize the RORc modulators disclosed in the scientific and patent literature.
authors: Discovery Chemistry, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
authors: Benjamin P
authors: BP
authors: Fauber
authors: Steven
authors: S
authors: Magnuson
mesh_terms: D000818:Animals; D054314:Drug Inverse Agonism; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000819:agonists / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism
chemical_list: D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539900:RORC protein, human; C539901:Rorc protein, mouse