title: Prognosis-related microRNAs in esophageal cancer.
abstract: BACKGROUND
  Despite improvements in detection, surgical resection and adjuvant therapy, the prognosis of esophageal cancer (EC) patients is dismal. A number of microRNAs (miRNAs) are related with the prognosis of EC.
  
  
  METHODS
  This review summarises the recent advances in prognosis-related miRNAs in EC and also analyses the molecular functions that they provide. This study further envisages future developments in the potential clinical applications of these miRNAs.
  
  
  CONCLUSIONS
  Altered miRNA expression of cancer tissues is useful for predicting the prognosis of EC patients. Individual circulating miRNAs have the potential to be used as novel biomarkers. Continued basic studies are warranted to gain more mechanistic insights into the functional effect of prognosis-related miRNAs on EC. More clinical trials should be performed to promote the clinical use of prognosis-related miRNAs.
authors: Fourth Military Medical University, Xijing Hospital, Xijing Hospital of Digestive Diseases , Xi'an 710032, Shaanxi Province , China +86 29 84773974 ; +86 29 82539041 ; hongliu180@126.com , hlhyhj@126.com.
authors: Liu
authors: L
authors: Hong
authors: Yu
authors: Y
authors: Han
authors: Hongwei
authors: H
authors: Zhang
authors: Qingchuan
authors: Q
authors: Zhao
authors: Kaichun
authors: K
authors: Wu
authors: Daiming
authors: D
authors: Fan
mesh_terms: D000818:Animals; D015415:Biomarkers; D002986:Clinical Trials as Topic; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D035683:MicroRNAs / Q000097:blood / Q000235:genetics* / Q000378:metabolism / Q000502:physiology; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D015415:Biomarkers; D035683:MicroRNAs