title: Xenon ventilation computed tomography and the management of asthma in the elderly.
abstract: OBJECTIVE
  Xenon ventilation computed tomography (CT) has shown potential in assessing the regional ventilation status in subjects with asthma. The purpose of this study was to evaluate the usefulness of xenon ventilation CT in the management of asthma in the elderly.
  
  
  METHODS
  Treatment-naïve asthmatics aged 65 years or older were recruited. Before initiation of medication, spirometry with bronchodilator (BD) reversibility, questionnaires to assess the severity of symptoms including a visual analogue scale (VAS), tests to evaluate cognitive function and mood, and xenon ventilation CT were performed. Xenon gas trapping (XT) on xenon ventilation CT represents an area where inhaled xenon gas was not expired and was trapped. Symptoms and lung functions were measured again after the 12-week treatment.
  
  
  RESULTS
  A total of 30 elderly asthmatics were enrolled. The severity of dyspnoea measured by the VAS showed a significant correlation with the total number of areas of XT on the xenon ventilation CT taken in the pre-BD wash-out phase (r = -0.723, P < 0.001). The total number of areas of XT significantly decreased after BD inhalation, and differences in the total number of areas of XT (between the pre- and post-BD wash-out phases) at baseline showed significant correlations with the per cent increases in forced expiratory volume in 1 s after subsequent anti-asthma treatment (r = -0.775, P < 0.001).
  
  
  CONCLUSIONS
  Xenon ventilation CT may be an objective and promising tool in the measurement of dyspnoea and prediction of the treatment response in elderly asthmatics.
authors: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.
authors: Heung-Woo
authors: HW
authors: Park
authors: Jae-Woo
authors: JW
authors: Jung
authors: Kyung-Mook
authors: KM
authors: Kim
authors: Tae-Wan
authors: TW
authors: Kim
authors: So-Hee
authors: SH
authors: Lee
authors: Chang Hyun
authors: CH
authors: Lee
authors: Jin Mo
authors: JM
authors: Goo
authors: Kyung-Up
authors: KU
authors: Min
authors: Sang-Heon
authors: SH
authors: Cho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000000981:diagnostic imaging*; D004185:Disability Evaluation; D004417:Dyspnea / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D012123:Pulmonary Ventilation; D013147:Spirometry; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014978:Xenon
chemical_list: D014978:Xenon
keywords: asthma; dyspnoea; elderly; treatment response; xenon ventilation computed tomography