title: [A gastric pacemaker in obese type 2 diabetic patients].
abstract: The combination of obesity and type 2 diabetes mellitus forms a growing global epidemic. The primary treatment for patients with this combination of conditions is to advise them to adopt a healthier lifestyle, but only a few patients succeed in doing this. Patients with type 2 diabetes who have to switch to insulin treatment can experience negative consequences, such as weight gain and an increased risk of hypoglycaemia. An alternative treatment that does not have these adverse effects is a gastric pacemaker, which can be implanted via laparoscopy: the patients lose weight and show an improvement in glucose regulation. The gastric pacemaker uses non-excitatory stimulation to influence the amplitude of gastric contraction. It simultaneously stimulates afferent fibres of the vagal nerve to influence the cerebral satiation centre, which is involved in registration of satiety and in insulin secretion and resistance. A randomized trial on the effects of the gastric pacemaker in patients with obesity and type 2 diabetes mellitus is currently being conducted in the Atrium Medical Centre in Heerlen.
authors: Atrium Medisch Centrum Parkstad, Heerlen.
authors: H J M Hein
authors: HJ
authors: Handgraaf
authors: Rochelle M E H
authors: RM
authors: Nelissen
authors: Rutgert
authors: R
authors: Bianchi
authors: Berry
authors: B
authors: Meesters
authors: Jan-Willem M
authors: JW
authors: Greve
mesh_terms: D001683:Biological Clocks / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000601:surgery; D004599:Electric Stimulation Therapy; D004567:Electrodes, Implanted; D055724:Electrophysiological Phenomena / Q000502:physiology; D006801:Humans; D007003:Hypoglycemia / Q000517:prevention & control; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008019:Life Style; D009765:Obesity / Q000150:complications* / Q000601:surgery; D019518:Postprandial Period / Q000502:physiology; D013270:Stomach / Q000294:innervation* / Q000502:physiology* / Q000601:surgery; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D007328:Insulin