title: Correlation of expression of STAT3, VEGF and differentiation of Th17 cells in psoriasis vulgaris of guinea pig.
abstract: OBJECTIVE
  To investigate the role of T help 17 cells (Th17) and STAT3-VEGF pathway in pathogenesis of psoriasis.
  
  
  METHODS
  A total of 50 cases of psoriasis guinea pigs and 20 normal guinea pigs were selected. The ratio of Th17/ IL-17 cell in peripheral blood were detected by flow cytometric analysis; STAT3 and VEGF concentrations were measured by immunohistochemistry and Western blot.
  
  
  RESULTS
  The expression of Th17 in peripheral blood were significantly increased in psoriasis [(1.76±0.88)%] compared with controls [(0.48±0.27)%] (P<0.05). Th17 related cytokine STAT3 and VEGF were significantly increased in psoriasis compared with controls (P<0.05), and were positively correlated the expression of Th17.
  
  
  CONCLUSIONS
  The expressions of Th17, STAT3 and VEGF are elevated in psoriasis, which suggests Th17 cells have a potential role in the pathogenesis of psoriasis by STAT3-VEGF pathway.
authors: Department of Dermatology, South Hospital, Southern Medical University, Guangzhou 510000, China. Electronic address: xiufenggogo@126.com.
authors: Xiu-Fen
authors: XF
authors: Zheng
authors: Department of Dermatology, Zhujiang Hospital, Southern Medical University, Guangzhou 510000, China.
authors: Yue-Dong
authors: YD
authors: Sun
authors: Department of Dermatology, South Hospital, Southern Medical University, Guangzhou 510000, China.
authors: Xue-Yan
authors: XY
authors: Liu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology*; D050796:STAT3 Transcription Factor / Q000097:blood / Q000378:metabolism*; D015398:Signal Transduction; D012867:Skin / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D058504:Th17 Cells / Q000166:cytology*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism*
chemical_list: D050796:STAT3 Transcription Factor; D042461:Vascular Endothelial Growth Factor A
keywords: Psoriasis; STAT3-VEGF pathway; T help 17 cells