title: Quantitative analysis of iobitridol in an injectable preparation by 1H NMR spectroscopy.
abstract: Nuclear magnetic resonance spectroscopy was used for direct quantitative determination of iobitridol in an injectable formulation. The method was developed on a medium field strength magnet (400MHz) and validation was performed by assessing specificity, accuracy, precision, linearity, stability of samples and robustness. Validation data confirm that the method is highly appropriate for direct quantification of iobitridol in the final formulation. Moreover the method has a good potential for rapid screening analyses due to straightforward experimental setup and lack of any sample pretreatment.
authors: Istituto Superiore di Sanità, Dipartimento del Farmaco, Rome, Italy. Electronic address: anna.borioni@iss.it.
authors: Anna
authors: A
authors: Borioni
authors: Istituto Superiore di Sanità, Dipartimento del Farmaco, Rome, Italy.
authors: Gianluca
authors: G
authors: Gostoli
authors: Istituto Superiore di Sanità, Dipartimento del Farmaco, Rome, Italy.
authors: Elena
authors: E
authors: Bossù
authors: Istituto Superiore di Sanità, Dipartimento del Farmaco, Rome, Italy.
authors: Isabella
authors: I
authors: Sestili
mesh_terms: D007267:Injections; D007472:Iohexol / Q000031:analogs & derivatives* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D012015:Reference Standards; D012680:Sensitivity and Specificity
chemical_list: C093233:iobitridol; D007472:Iohexol
keywords: assay determination; iobitridol; qNMR; quality control; validation