title: How plausible is a link between HSV-1 infection and Alzheimer's disease?
abstract: Alzheimer's disease is a leading cause of dementia with a multifactorial and still barely understood etiology. A growing body of epidemiologic and experimental data support a role for infectious agents in this process; herpes simplex virus 1 (HSV-1), in particular, is a strong suspect. We briefly summarize the data pointing at a pathogenic role for HSV-1 in the development of Alzheimer's disease and review results indicating that antiviral might be beneficial in the therapy of this condition.
authors: Don C. Gnocchi Foundation ONLUS-IRCCS, Milano, Italy.
authors: Simone
authors: S
authors: Agostini
authors: Mario
authors: M
authors: Clerici
authors: Roberta
authors: R
authors: Mancuso
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000188:drug therapy / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D000998:Antiviral Agents / Q000627:therapeutic use; D006561:Herpes Simplex / Q000150:complications* / Q000276:immunology; D018259:Herpesvirus 1, Human; D006801:Humans
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents