title: The modulation of coagulation by aptamers: an up-to-date review.
abstract: Coagulation and anticoagulation system is kept in balance by the orchestrated action of a variety of biological factors, and the disruption of this balance leads to the risk of hemorrhage or thrombosis. Oligonucleotide aptamers are single-stranded DNA (ssDNA) or RNA ligands that are synthesized in vitro and bind to target molecules through dimensional structure with high specificity and affinity, and thus represent attractive candidates for the development of agents to maintain the balance of coagulation and anticoagulation. In this review, we summarize recent progress in aptamer-based application in the modulation of coagulation. The aptamers with specific chemical and biological characteristics have great potential to be explored as agents for the treatment of blood coagulation abnormalities.
authors: aDepartment of Gastroenterology, The First Affiliated Hospital, Nanchang University bDepartment of Blood Transfusion, The First Affiliated Hospital, Nanchang University, Nanchang, Jiangxi, China.
authors: Piao-Ping
authors: PP
authors: Hu
authors: Kun-He
authors: KH
authors: Zhang
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D001777:Blood Coagulation / Q000235:genetics*; D006801:Humans; D013917:Thrombin / Q000235:genetics*; D013927:Thrombosis / Q000235:genetics*
chemical_list: D052157:Aptamers, Nucleotide; D013917:Thrombin