title: Delayed hypersensitivity reaction after initial dose of infliximab: a case report.
abstract: We report here an unusual case of delayed hypersensitivity reaction in a young woman with ulcerative colitis after the first administration of infliximab (IFX). The patient developed severe serum-sickness-like reaction, and her anti-IFX antibody titer increased rapidly after a single infusion of IFX. The possible reason for the delayed hypersensitivity reaction to a single IFX exposure might be the presensitization of the patient by murine antigens as she had been keeping mice and hamsters as pets for several years.
authors: Gastroenterology Unit, Department of Internal Medicine V., University Hospital Bratislava, Bratislava, Slovakia.
authors: Anna
authors: A
authors: Krajcovicova
authors: Tibor
authors: T
authors: Hlavaty
authors: Zuzana
authors: Z
authors: Zelinkova
authors: Juraj
authors: J
authors: Letkovsky
authors: Martin
authors: M
authors: Huorka
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000276:immunology; D000906:Antibodies / Q000097:blood; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000276:immunology; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D006224:Cricetinae / Q000276:immunology; D004342:Drug Hypersensitivity / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology; D057915:Drug Substitution; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D000069285:Infliximab; D051379:Mice / Q000276:immunology; D057805:Pets / Q000276:immunology; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D000906:Antibodies; D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab