title: Application of FDG-PET in cervical cancer and endometrial cancer: utility and future prospects.
abstract: Positron-emission tomography (PET), a diagnostic imaging technique using an agent labeled with a positron-emitting radionuclide, may facilitate improved diagnosis and treatment in gynecological fields. A combined PET/computerized tomography (CT) scan can identify the precise anatomical location of a lesion based on accumulation of (18)F-fluoro-D-glucose (FDG). FDG-PET and PET/CT have been used for detecting metastatic lesions and predicting prognosis in uterine cancer. PET has higher reliability in diagnosing lymph node metastases of uterine cancer than CT or MRI, and is considered most useful among non-invasive diagnostic imaging methods. Accumulation of FDG in lesions is indicative of a poor prognosis. Due to its limited spatial resolution, PET is not suitable has lower utility for detecting small lesions, and is not suitable for early-stage screening, and diagnosing primary lesions. Further improvements in diagnostic technology, including PET/MRI, investigation of new positron tracers, and analysis of data from various combinations of tracers are likely to make PET particularly useful for diagnosis and therapeutic strategy planning.
authors: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Shinanomachi 35 Shinjuku-ku, Tokyo 160-8582, Japan. kbanno@z7.keio.jp.
authors: Yuya
authors: Y
authors: Nogami
authors: Miho
authors: M
authors: Iida
authors: Kouji
authors: K
authors: Banno
authors: Iori
authors: I
authors: Kisu
authors: Masataka
authors: M
authors: Adachi
authors: Kanako
authors: K
authors: Nakamura
authors: Kiyoko
authors: K
authors: Umene
authors: Kenta
authors: K
authors: Masuda
authors: Eiichiro
authors: E
authors: Tominaga
authors: Kyoko
authors: K
authors: Tanaka
authors: Daisuke
authors: D
authors: Aoki
mesh_terms: D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
keywords: FDG-PET; SUV; cervical cancer; endometrial cancer; review; sensitivity; specificity