title: Towards a better understanding of pelvic system disorders using numerical simulation.
abstract: Genital prolapse is a pathologic hyper-mobility of the organs that forms the pelvic system. Although this is common condition, the pathophysiology of this disorder is not well known. In order to improve the understanding of its origins, we recreate--virtually--this biomechanical pathology using numerical simulation. The approach builds on a finite element model with parameters measured on several fresh cadavers. The meshes are created from a MRI of a healthy woman and the simulation includes the mechanical interactions between organs (contacts, ligaments, adhesion...). The model is validated through comparison of functional mobilities of the pelvic system observed on a dynamic MRI. We then propose to modify, step by step, the model and its parameters to produce a pathologic situation and have a better understanding of the process. It is not a formal proof but the numerical experiments reinforce the clinical hypothesis on the multifactorial origins of the pathology.
authors: Laboratoire de Mécanique de Lille, Ecole Centrale de Lille.
authors: Pauline
authors: P
authors: Lecomte-Grosbras
authors: Laboratoire de Mécanique de Lille, Ecole Centrale de Lille.
authors: Mouhamadou Nassirou
authors: MN
authors: Diallo
authors: Laboratoire de Mécanique de Lille, Ecole Centrale de Lille.
authors: Jean-Francois
authors: JF
authors: Witz
authors: INRIA, University of Lille 1.
authors: Damien
authors: D
authors: Marchal
authors: INRIA, University of Lille 1.
authors: Jeremie
authors: J
authors: Dequidt
authors: INRIA, University of Lille 1.
authors: Stéphane
authors: S
authors: Cotin
authors: CHRU Lille, University of Lille 2.
authors: Michel
authors: M
authors: Cosson
authors: INRIA, University of Lille 1.
authors: Christian
authors: C
authors: Duriez
authors: Laboratoire de Mécanique de Lille, Ecole Centrale de Lille.
authors: Matthias
authors: M
authors: Brieu
mesh_terms: D000368:Aged; D002102:Cadaver; D003198:Computer Simulation; D055119:Elastic Modulus; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008953:Models, Anatomic; D008954:Models, Biological; D056887:Pelvic Organ Prolapse / Q000473:pathology* / Q000503:physiopathology*; D010388:Pelvis / Q000473:pathology* / Q000503:physiopathology*; D013314:Stress, Mechanical; D013718:Tensile Strength