title: Burkholderia cepacia endophthalmitis, in a penicillin allergic patient, following a ranibizumab injection.
abstract: Burkholderia cepacia, a Gram-negative bacterium commonly found in water and soil, is a rare cause of endophthalmitis. The authors report a case of a penicillin-allergic patient who presented 15 days after an uneventful injection of ranibizumab for neovascular age-related macular degeneration with culture-positive B cepacia endophthalmitis. Initial antibiotic therapy using non-penicillin-based medications was not successful in eradicating the bacteria. Subsequent treatment with a third-generation cephalosporin resulted in complete resolution of the infection. B cepacia should be included among the bacterial species that may cause endophthalmitis after intravitreal injections.
authors: Department of Ophthalmology, Maimonides Medical Center, Brooklyn, New York, USA.
authors: Norman
authors: N
authors: Saffra
authors: Emily
authors: E
authors: Moriarty
mesh_terms: D000369:Aged, 80 and over; D020533:Angiogenesis Inhibitors / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage / Q000009:adverse effects*; D016956:Burkholderia cepacia; D002442:Ceftazidime / Q000627:therapeutic use; D004342:Drug Hypersensitivity; D009877:Endophthalmitis / Q000188:drug therapy / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D058449:Intravitreal Injections / Q000009:adverse effects; D008268:Macular Degeneration / Q000188:drug therapy; D010406:Penicillins / Q000009:adverse effects; D000069579:Ranibizumab
chemical_list: D020533:Angiogenesis Inhibitors; D000900:Anti-Bacterial Agents; D061067:Antibodies, Monoclonal, Humanized; D010406:Penicillins; D002442:Ceftazidime; D000069579:Ranibizumab