title: Irreversible enzyme inhibition kinetics and drug-drug interactions.
abstract: This chapter describes the types of irreversible inhibition of drug-metabolizing enzymes and the methods commonly employed to quantify the irreversible inhibition and subsequently predict the extent and time course of clinically important drug-drug interactions.
authors: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA.
authors: Michael
authors: M
authors: Mohutsky
authors: Stephen D
authors: SD
authors: Hall
mesh_terms: D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015195:Drug Design; D004347:Drug Interactions; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004798:Enzymes / Q000378:metabolism*; D006801:Humans; D007700:Kinetics
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D004798:Enzymes; D003577:Cytochrome P-450 Enzyme System