title: Myocardial defect detection using PET-CT: phantom studies.
abstract: It is expected that both noise and activity distribution can have impact on the detectability of a myocardial defect in a cardiac PET study. In this work, we performed phantom studies to investigate the detectability of a defect in the myocardium for different noise levels and activity distributions. We evaluated the performance of three reconstruction schemes: Filtered Back-Projection (FBP), Ordinary Poisson Ordered Subset Expectation Maximization (OP-OSEM), and Point Spread Function corrected OSEM (PSF-OSEM). We used the Channelized Hotelling Observer (CHO) for the task of myocardial defect detection. We found that the detectability of a myocardial defect is almost entirely dependent on the noise level and the contrast between the defect and its surroundings.
authors: Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Radiology, Harvard Medical School, Boston, Massachusetts, United States of America.
authors: Eugene S
authors: ES
authors: Mananga
authors: Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Radiology, Harvard Medical School, Boston, Massachusetts, United States of America.
authors: Georges
authors: G
authors: El Fakhri
authors: ASTAR-NUS Clinical Imaging and Research Centre (CIRC), Singapore, Singapore.
authors: Joshua
authors: J
authors: Schaefferkoetter
authors: Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Radiology, Harvard Medical School, Boston, Massachusetts, United States of America.
authors: Ali A
authors: AA
authors: Bonab
authors: Center for Advanced Medical Imaging Sciences, Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Boston, Massachusetts, United States of America ; Department of Radiology, Harvard Medical School, Boston, Massachusetts, United States of America.
authors: Jinsong
authors: J
authors: Ouyang
mesh_terms: D000465:Algorithms; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology*; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000295:instrumentation*