title: Protection to homologous and heterologous challenge in pigs immunized with vaccine against foot-and-mouth disease type O caused an epidemic in East Asia during 2010/2011.
abstract: Foot-and-mouth disease (FMD) is a highly contagious infectious disease, and the use of vaccines is known to be effective for its prevention. In 2010/2011, there was an epidemic of the South East Asia (SEA) topotype in East Asian countries. We adapted the SEA topotype virus isolated in November 2010 in Korea in cells to analyze the characteristics of the virus and evaluate its possibility as a vaccine. After cell culture adaptation, the FMD virus particle 146S was purified to develop an inactivated oil vaccine for SEA or other topotypes. To measure its immunogenicity, pigs were inoculated with the experimental vaccine at different concentrations of the antigen. The results indicated that the groups immunized with at least 7.5 μg antigen were protected from homologous challenge. The immunized pigs were also protected against heterologous virus (ME-SA topotype) challenge. The genetic variations between the two field isolates and the adapted vaccine strains were identified in six amino acids by complete genome sequencing.
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea.
authors: Jeong-Nam
authors: JN
authors: Park
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea.
authors: Seo-Yong
authors: SY
authors: Lee
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea; Clinical Research Center of the Affiliated Hospital of Guangdong Medical College, No. 57 South Renmin Avenue, Zhanjiang 524001, China.
authors: Jia-Qi
authors: JQ
authors: Chu
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea.
authors: Yeo-Joo
authors: YJ
authors: Lee
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea.
authors: Rae-Hyung
authors: RH
authors: Kim
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea.
authors: Kwang-Nyeong
authors: KN
authors: Lee
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea.
authors: Su-Mi
authors: SM
authors: Kim
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea.
authors: Dong-Seob
authors: DS
authors: Tark
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea.
authors: Byounghan
authors: B
authors: Kim
authors: Animal and Plant Quarantine Agency, 175 Anyang-ro, Manangu, Anyang city 430-757, Gyeonggi-do, Republic of Korea. Electronic address: parkjhvet@korea.kr.
authors: Jong-Hyeon
authors: JH
authors: Park
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D001210:Asia, Southeastern / Q000453:epidemiology; D005536:Foot-and-Mouth Disease / Q000453:epidemiology / Q000517:prevention & control*; D029544:Foot-and-Mouth Disease Virus / Q000145:classification / Q000235:genetics; D016679:Genome, Viral; D034421:Sus scrofa / Q000276:immunology; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines
keywords: Foot-and-mouth disease; Heterologous challenge; Homologous challenge; Inactivated vaccine; O–SEA topotype