title: Synthesis and biological evaluation of Chromenylurea and Chromanylurea derivatives as anti-TNF-α agents that target the p38 MAPK pathway.
abstract: A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities towards TNF-α production in lipopolysaccharide-stimulated THP-1 cells. The most active compound, 40g, inhibited TNF-α release with an IC50 value of 0.033 μM, which is equipotent to that of BIRB796 (IC50 = 0.032 μM).
authors: Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. xingzhou1970@gmail.com.
authors: Xingzhou
authors: X
authors: Li
authors: Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. chemistry20120720@gmail.com.
authors: Xinming
authors: X
authors: Zhou
authors: Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. rayzhangjing@sina.com.
authors: Jing
authors: J
authors: Zhang
authors: Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. Wangll63@126.com.
authors: Lili
authors: L
authors: Wang
authors: Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. long072811@126.com.
authors: Long
authors: L
authors: Long
authors: Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. zzbcaptain@aliyun.com.
authors: Zhibing
authors: Z
authors: Zheng
authors: Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. lis.lisong@gmail.com.
authors: Song
authors: S
authors: Li
authors: Laboratory of Computer-Aided Drug Design & Discovery, Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China. zhongwu@bmi.ac.cn.
authors: Wu
authors: W
authors: Zhong
mesh_terms: D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D020935:MAP Kinase Signaling System / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism*; D014508:Urea / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001578:Benzopyrans; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D014508:Urea