title: HPTN 062: a feasibility and acceptability pilot intervention to reduce HIV transmission risk behaviors among individuals with acute and early HIV infection in Lilongwe, Malawi.
abstract: Acute HIV infection (AHI) is a relatively brief period of time when individuals are highly infectious and the opportunity to intervene to prevent forward transmission is extremely limited. HPTN 062 partnered with CHAVI 001 to evaluate the feasibility and acceptability of a motivational interviewing (MI)-based counseling intervention to reduce HIV-transmission risk behaviors among individuals with acute and early HIV infection in Lilongwe, Malawi. Participants were randomized to receive either (1) brief education sessions about HIV and AHI; or (2) the same brief education sessions plus an MI-based counseling intervention called Uphungu Wanga. Although Uphungu Wanga was determined to be feasible and acceptable, few major differences existed between the two arms with regard to acceptability, feasibility, and self-reported sexual behaviors. We therefore conclude that an additional MI-based counseling intervention may not be needed during the short period of AHI. Instead, we recommend that individuals with AHI receive frequent, but brief, counseling immediately after diagnosis and then transition to receiving counseling at less frequent intervals until they can initiate antiretroviral therapy. Other recommendations are provided.
authors: Social and Behavioral Health Sciences, FHI 360, 359 Blackwell St, Suite 200, Durham, NC, 27701, USA, acorneli@fhi360.org.
authors: Amy
authors: A
authors: Corneli
authors: Audrey
authors: A
authors: Pettifor
authors: Gift
authors: G
authors: Kamanga
authors: Carol
authors: C
authors: Golin
authors: Kevin
authors: K
authors: McKenna
authors: San-San
authors: SS
authors: Ou
authors: Gloria
authors: G
authors: Hamela
authors: Cecelia
authors: C
authors: Massa
authors: Francis
authors: F
authors: Martinson
authors: Jenae
authors: J
authors: Tharaldson
authors: Deborah
authors: D
authors: Hilgenberg
authors: Xuesong
authors: X
authors: Yu
authors: Wairimu
authors: W
authors: Chege
authors: Irving
authors: I
authors: Hoffman
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D003376:Counseling; D005240:Feasibility Studies; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000517:prevention & control* / Q000523:psychology; D006679:HIV Seropositivity; D006801:Humans; D008295:Malawi; D008297:Male; D062405:Motivational Interviewing; D010342:Patient Acceptance of Health Care; D010865:Pilot Projects; D017064:Process Assessment, Health Care; D015397:Program Evaluation; D012309:Risk-Taking; D012725:Sexual Behavior / Q000523:psychology; D012747:Sexual Partners