title: Poor platelet Count Response to Helicobacter Pylori Eradication in Patients with Severe Idiopathic Thrombocytopenic Purpura.
abstract: BACKGROUND
  ITP is an autoimmune blood disorder in which platelet destruction is mediated by anti-platelet antibodies. The mechanisms of anti-platelet antibodies development are still a little known. The rate of some bacterial or viral agents in cause of ITP is well known. Recently, some study proposed that H pylori infection may be associated with ITP and H pylori eradication can improves platelet counts in infected ITP patients.
  
  
  METHODS
  A baseline platelet count <50×10(3) µL for 4 weeks prior to study entry were required. These patients were tested for H. pylori infection by urea breath. All positive H pylori patients received triple therapy for 7 or 14 days to eradicate H pylori infection. These patients followed for six months.
  
  
  RESULTS
  Of 92 patients with ITP, H pylori infection was found in 59.7% (55/92). After excluding patients with confounding factors, 41 patients were remained. After H pylori eradication, CR wasn't obtained in any patients. Partial response were obtained only in 3 (7.3%) of the 41 patients and no response in 38 (92.6%) patients. There is a significant difference between the platelet counts of PR and NR groups (P < 0.001).
  
  
  CONCLUSIONS
  The results of this study and our previously study showed H pylori eradication therapy has beneficial effect for patients with mild thrombocytopenia but the chance of obtaining a response by H pylori treatment is lower in patients with severe thrombocytopenia.
authors: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors: Mehrdad
authors: M
authors: Payandeh
authors: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors: Dariyush
authors: D
authors: Raeisi
authors: Department of Medical Laboratory Sciences, Para medicine Faculty, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors: Nasrollah
authors: N
authors: Sohrabi
authors: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran ; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors: Mohammad Erfan
authors: ME
authors: Zare
authors: Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran ; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors: Atefeh Nasir
authors: AN
authors: Kansestani
authors: Student research committee, Shiraz University of Medical Sciences, Shiraz, Iran.
authors: Nazanin
authors: N
authors: Keshavarz
authors: Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors: Samira
authors: S
authors: Gholami
authors: Department of Biostatistics, Faculty of Public Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors: Amir Hossein
authors: AH
authors: Hashemian
keywords: Helicobacter pylori; Idiopathic thrombocytopenic purpura; Platelet counts