title: Metallic implant drug/device combinations for controlled drug release in orthopaedic applications.
abstract: The study of metallic drug/device combinations for controlled drug release in orthopaedic applications has gained significant momentum in the past decade, particularly for the prevention and reduction of implant associated infection. Such combinations are commonly based upon a permanent metallic implant (such as stainless steel or titanium) and are then coated with a drug-eluting polymer or ceramic system. Drug elution is also possible from the implant itself by utilising metallic foams, porous architectures and bioresorbable metals. This review will explore the current research into metallic implant drug/device combinations via a critical review of the relevant literature.
authors: Department of Materials Engineering, Monash University, Wellington Road, Clayton, Victoria 3800, Australia.
authors: Jessica A
authors: JA
authors: Lyndon
authors: Drug Delivery, Disposition and Dynamics, Monash institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Pde, Parkville, Victoria 3052, Australia.
authors: Ben J
authors: BJ
authors: Boyd
authors: Department of Materials Engineering, Monash University, Wellington Road, Clayton, Victoria 3800, Australia. Electronic address: nick.birbilis@monash.edu.
authors: Nick
authors: N
authors: Birbilis
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D020099:Coated Materials, Biocompatible; D006801:Humans; D008670:Metals; D009983:Orthopedic Equipment; D019736:Prostheses and Implants; D011474:Prosthesis Design; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D008670:Metals
keywords: Biocorrosion; Bioresorbable; Drug delivery; Metallic implant; Orthopaedic