title: Concurrent presentation of nodal myeloid sarcoma and bone marrow chronic lymphocytic leukemia/small lymphocytic lymphoma: a unique association.
abstract: Myeloid sarcoma (MS), previously known as granulocytic sarcoma, is a rare, localized, tumor mass composed of myeloid precursor cells, with or without maturation, and occurring at an anatomical site other than the bone marrow (BM). Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), in contrast, is a B-cell hematological malignancy. We describe the first reported case of concurrent presentation of nodal MS and of BM CLL/SLL in the same patient. Fatal leukemic central nervous system infiltration was the final outcome. We provide possible explanations and investigate the pathophysiology of this unique, previously unreported co-morbidity.
authors: Department of Haematology, First Propedeutic Department of Internal Medicine, Faculty of Medicine, AHEPA General Hospital, Aristotle University of Thessaloniki (AUTH), S. Kiriakidi St. 1, 54 636, Thessaloniki, Greece.
authors: Vasilios
authors: V
authors: Perifanis
authors: Michael D
authors: MD
authors: Diamantidis
authors: Kyriaki
authors: K
authors: Chalvatzi
authors: Vassiliki
authors: V
authors: Kaloutsi
authors: Dimitra
authors: D
authors: Markala
authors: Virginia
authors: V
authors: Voulgaridou
authors: Pavlina
authors: P
authors: Pantelidou
authors: Athinodoros
authors: A
authors: Pavlidis
authors: George
authors: G
authors: Stavrou
authors: Georgia
authors: G
authors: Kaiafa
mesh_terms: D000368:Aged; D000954:Antigens, Surface / Q000378:metabolism; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000175:diagnosis*; D008198:Lymph Nodes / Q000473:pathology; D023981:Sarcoma, Myeloid / Q000150:complications* / Q000175:diagnosis*
chemical_list: D000954:Antigens, Surface