title: [Genetic polymorphisms and lung cancer risk: a case-control study].
abstract: OBJECTIVE
  The smoke fume, principal factor in the development of lung cancer, causes the expression of certain cytokines, including interleukin 4, 6, 8 and 10, which may act by inhibiting apoptosis and interfere cellular repair mechanisms and angiogenesis. To determine the possible relationship between gene polymorphisms of these cytokines and lung cancer.
  
  
  METHODS
  To achieve this objective we designed a case-control study, which included 400 patients who had come to the consultation for rapid diagnosis of lung cancer at the Pneumology Department, University Hospital of Salamanca, and whose main criterion exclusion was the lack of active contact with smoke fume. Patients were divided into 2 groups, each consisting of 200 patients: cases (patients diagnosed with lung cancer) and controls (patients without lung cancer).
  
  
  RESULTS
  A percentage of 62.8 of men were former smokers at diagnosis compared with 55.5% of women, although the former still had a greater cumulative consumption. Squamous cell carcinoma predominated in diagnosis (48.9% of patients) and more than half were in advanced stages (28.5% in stage iiiB and 25.5% in stage iv). No statistical significance was observed by linking the existence of tumor to the prevalence of any of the analyzed polymorphisms.
  
  
  CONCLUSIONS
  Polymorphisms in the study did not modify the risk of developing lung cancer.
authors: Servicio de Neumología, Hospital Universitario Río Hortega, Valladolid, España. Electronic address: anyjm@hotmail.com.
authors: Ana E
authors: AE
authors: Jiménez-Massa
authors: Departamento de Medicina Preventiva, Salud Pública y Microbiología Clínica, Facultad de Medicina, Universidad de Salamanca, Salamanca, España.
authors: Montserrat
authors: M
authors: Alonso-Sardón
authors: Hospital Clínico Universitario de Salamanca, Salamanca, España.
authors: José Antonio
authors: JA
authors: Menacho-Miguel
authors: Departamento de Medicina Preventiva, Salud Pública y Microbiología Clínica, Facultad de Medicina, Universidad de Salamanca, Salamanca, España.
authors: José Antonio
authors: JA
authors: Mirón-Canelo
authors: Departamento de Medicina, Facultad de Medicina, Universidad de Salamanca, Salamanca, España.
authors: Rogelio
authors: R
authors: González-Sarmiento
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007378:Interleukins / Q000235:genetics*; D008175:Lung Neoplasms / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D007378:Interleukins
keywords: Angiogenesis; Angiogénesis; Citocinas; Cytokines; Cáncer de pulmón; Inflamación; Inflammation; Lung cancer; Polimorfismo; Polymorphism