title: Airway epithelial regulation of pulmonary immune homeostasis and inflammation.
abstract: Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases.
authors: Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA. Electronic address: tealh@uw.edu.
authors: Teal S
authors: TS
authors: Hallstrand
authors: Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.
authors: Tillie L
authors: TL
authors: Hackett
authors: Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
authors: William A
authors: WA
authors: Altemeier
authors: Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA, USA.
authors: Gustavo
authors: G
authors: Matute-Bello
authors: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
authors: Philip M
authors: PM
authors: Hansbro
authors: School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
authors: Darryl A
authors: DA
authors: Knight
mesh_terms: D056704:Adaptive Immunity; D000393:Air Pollutants / Q000276:immunology; D001426:Bacterial Proteins / Q000009:adverse effects; D019742:Chemokines, CC / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism; D000067596:Interleukin-33; D007378:Interleukins / Q000276:immunology / Q000378:metabolism; D008168:Lung / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D020545:Respiratory Mucosa / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D012906:Smoke / Q000009:adverse effects; D014026:Nicotiana / Q000009:adverse effects; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D000393:Air Pollutants; D001426:Bacterial Proteins; D019742:Chemokines, CC; D016207:Cytokines; C486701:IL25 protein, human; C506536:IL33 protein, human; D020381:Interleukin-17; D000067596:Interleukin-33; D007378:Interleukins; D012906:Smoke; D000094632:Thymic Stromal Lymphopoietin
keywords: Asthma; Chemokine; Chronic-obstructive pulmonary disease; Epithelium; Host defense; Tight junctions