title: One-year volume stability of human facial defects filled with a β-tricalcium phosphate-hydroxyl apatite mixture (Atlantik).
abstract: BACKGROUND
  We investigated the applicability and 1-year stability of a β-tricalcium phosphate-hydroxyl apatite mixture (Atlantik) for secondary reconstruction of craniofacial defects and the application of OsiriX in evaluating bone and implant volumes.
  
  
  METHODS
  We included 6 patients (25-59 years) with craniofacial defects. A computed tomography scan was made preoperative, directly postoperative, and at least 1 year postoperative to evaluate volume changes. OsiriX was used to quantify volumes of the implanted Atlantik. Measurements were performed by 2 independent investigators and analyzed by calculating both Pearson correlation and interclass correlation coefficient.
  
  
  RESULTS
  After 1 year, the mean volume reduction of the implanted Atlantik was 9.8%. The absolute volume reduction in 1 year was 0.38 cm (range, 0.10-0.69 cm(3)). Pearson correlation test was 0.996, with a significance level of P < 0.01, and the interclass correlation coefficient was 0.998.
  
  
  CONCLUSIONS
  Atlantik is a stable osteoconductive material for the repair of various craniofacial defects. There is a reduction of only 10% of the augmented volume in the long term. Applying OsiriX for computed tomography image volume analysis proved to be a well-reproducible technique.
authors: From the Departments of *Oral and Maxillofacial Surgery and †Radiology, University Medical Center Utrecht, the Netherlands.
authors: Gerhard Koendert Pieter
authors: GK
authors: Bittermann
authors: Nard G
authors: NG
authors: Janssen
authors: Maarten
authors: M
authors: van Leeuwen
authors: Robert J J
authors: RJ
authors: van Es
mesh_terms: D000328:Adult; D018786:Bone Substitutes / Q000592:standards / Q000627:therapeutic use*; D019465:Craniofacial Abnormalities / Q000000981:diagnostic imaging / Q000601:surgery*; D004338:Drug Combinations; D005147:Facial Bones / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009915:Orbit / Q000000981:diagnostic imaging / Q000601:surgery*; D019651:Plastic Surgery Procedures / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D018786:Bone Substitutes; D004338:Drug Combinations