title: Respiratory syncytial virus- and human metapneumovirus-associated emergency department and hospital burden in adults.
abstract: OBJECTIVE
  Determine the burden of illness associated with respiratory syncytial virus (RSV) and human metapneumovirus (HMPV) in adults, especially young adults.
  
  
  METHODS
  Prospective surveillance study using RT-PCR for the diagnosis of RSV and HMPV.
  
  
  METHODS
  One academic Emergency Department (ED), one academic hospital and three middle Tennessee community hospitals.
  
  
  METHODS
  We prospectively enrolled Middle Tennessee residents ≥18 years old evaluated in the emergency department (ED) or hospitalized for respiratory symptoms May 2009 through April 2010. We collected nose/throat specimens for RSV and HMPV reverse-transcriptase polymerase chain reaction (RT-PCR) testing and obtained demographic and clinical data.
  
  
  METHODS
  Rates of ED visits and hospitalizations were calculated using the proportion of enrolled patients positive for each virus multiplied by the number of Middle Tennessee residents evaluated in EDs and/or hospitalized in Tennessee for acute respiratory illness during the study period.
  
  
  RESULTS
  Three thousand two hundred and fifty six patients were eligible; 1477 (45·4%) were enrolled; 1248 (84·5%) of these consented to additional testing and had adequate samples. RT-PCR identified 32 (2·6%) patients with RSV and 33 (2·6%) with HMPV. The median duration of symptoms before ED presentation was 3·3 days with RSV and 2·8 days with HMPV, and before hospital admission was 4·5 days with RSV and 3·5 days with HMPV. The annual hospitalization and ED visit rates were similar for RSV and HMPV. The hospitalization rate associated with each virus was about 10 per 10 000 persons aged ≥50 years; ED rates were approximately 2 times higher. Hospitalization rates were about 2 per 10 000 persons aged 18-49 years, with ED rates 5-6 times higher.
  
  
  CONCLUSIONS
  RSV and MPV are associated with substantial disease in adults, with hospitalization and ED visits rates increasing with age.
authors: Department of Internal Medicine, Tulane University School of Medicine, New Orleans, LA, USA; Southeast Louisiana Veterans Health Care System, New Orleans, LA, USA.
authors: Kyle
authors: K
authors: Widmer
authors: Marie R
authors: MR
authors: Griffin
authors: Yuwei
authors: Y
authors: Zhu
authors: John V
authors: JV
authors: Williams
authors: H Keipp
authors: HK
authors: Talbot
mesh_terms: D000293:Adolescent; D000328:Adult; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data; D006760:Hospitalization; D006801:Humans; D029121:Metapneumovirus / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D008875:Middle Aged; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000628:therapy / Q000821:virology; D011446:Prospective Studies; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000628:therapy / Q000821:virology; D012136:Respiratory Syncytial Viruses / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D013714:Tennessee / Q000453:epidemiology; D055815:Young Adult
keywords: Burden of illness; hospitalizations; human metapneumovirus; older adults; respiratory syncytial virus