title: Impact of social status and antidepressant treatment on neurogenesis in the baboon hippocampus.
abstract: Adult hippocampal neurogenesis is critically implicated in rodent models of stress and anxiety as well as behavioral effects of antidepressants. Whereas similar factors such as psychiatric disorder and antidepressant administration are correlated with hippocampal volume in humans, the relationship between these factors and adult neurogenesis is less well understood. To better bridge the gap between rodent and human physiology, we examined the numbers of proliferating neural precursors and immature cells in the hippocampal dentate gyrus (DG) as well as in vivo magnetic resonance imaging (MRI)-estimated whole hippocampal volume in eight socially dominant- or subordinate-like (SL) baboons administered the antidepressant fluoxetine or vehicle. SL baboons had lower numbers of proliferating cells and immature neurons than socially dominant-like baboons. Fluoxetine treatment was associated with a larger whole hippocampal volume but surprisingly resulted in lower numbers of immature neurons. These findings are the first to indicate that adult neurogenesis in the baboon hippocampal DG may be functionally relevant in the context of social stress and mechanisms of antidepressant action.
authors: 1] Department of Psychiatry, Columbia University, New York, NY, USA [2] Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY, USA.
authors: Melody V
authors: MV
authors: Wu
authors: Department of Neuroscience and Friedman Brain Institute, Mt Sinai School of Medicine, New York, NY, USA.
authors: Jul Lea
authors: JL
authors: Shamy
authors: 1] Department of Psychiatry, Columbia University, New York, NY, USA [2] Division on Substance Abuse, New York State Psychiatric Institute, New York, NY, USA.
authors: Gillinder
authors: G
authors: Bedi
authors: 1] Department of Psychiatry, Columbia University, New York, NY, USA [2] Division of Biostatistics, New York State Psychiatric Institute, New York, NY, USA.
authors: Chien-Wen J
authors: CW
authors: Choi
authors: 1] Department of Psychiatry, Columbia University, New York, NY, USA [2] Division of Biostatistics, New York State Psychiatric Institute, New York, NY, USA.
authors: Melanie M
authors: MM
authors: Wall
authors: 1] Department of Psychiatry, Columbia University, New York, NY, USA [2] Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
authors: Victoria
authors: V
authors: Arango
authors: 1] Department of Psychiatry, Columbia University, New York, NY, USA [2] Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA.
authors: Maura
authors: M
authors: Boldrini
authors: 1] Department of Psychiatry, Columbia University, New York, NY, USA [2] Division on Substance Abuse, New York State Psychiatric Institute, New York, NY, USA.
authors: Richard W
authors: RW
authors: Foltin
authors: 1] Department of Psychiatry, Columbia University, New York, NY, USA [2] Division of Integrative Neuroscience, New York State Psychiatric Institute, New York, NY, USA [3] Departments of Neuroscience and Pharmacology, Columbia University, New York, NY, USA.
authors: René
authors: R
authors: Hen
mesh_terms: D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D018891:Dentate Gyrus / Q000187:drug effects*; D005473:Fluoxetine / Q000494:pharmacology*; D006608:Hierarchy, Social; D008297:Male; D058953:Neural Stem Cells / Q000187:drug effects; D055495:Neurogenesis / Q000187:drug effects*; D048548:Papio cynocephalus; D013315:Stress, Psychological
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine