title: Synthesis, characterization and biological activities of 2-((E)-(benzo[d][1,3]dioxol-6-ylimino)methyl)-6-ethoxyphenol and its metal complexes.
abstract: Metal complexes of Zn(II), Cd(II), Ni(II), Cu(II), and Fe(III) have been synthesized from the Schiff base ligand derived by the condensation of 3,4-(methylenedioxy)aniline and 3-ethoxy salicylaldehyde. The compounds have been characterized by using elemental analysis, molar conductance, IR, UV-Visible, (1)H NMR, (13)C NMR, mass spectra and thermal analysis (TG/DTA). The elemental analysis suggests the stoichiometry to be 1:1 (metal:ligand). The IR, (1)H NMR, (13)C NMR and UV-Visible spectral data suggest that the ligand coordinate to the metal atom by imino nitrogen and phenolic oxygen as bidentate manner. The mass spectral data also strengthen the formation of the metal complexes. The thermal behaviors of the complexes prove the presence of lattice as well as coordinated water molecules in the complexes. The in vitro biological screening effects of the synthesized compounds are tested against five bacterial species and three fungal species by well diffusion method. Antioxidant activities have also been performed for all the compounds. Metal complexes show more pronounced biological activity than the free ligand.
authors: Chemistry Section (Faculty of Engineering and Technology), Annamalai University, Annamalai Nagar 608002, Tamilnadu, India.
authors: M L
authors: ML
authors: Sundararajan
authors: Chemistry Section (Faculty of Engineering and Technology), Annamalai University, Annamalai Nagar 608002, Tamilnadu, India.
authors: J
authors: J
authors: Anandakumaran
authors: Chemistry Section (Faculty of Engineering and Technology), Annamalai University, Annamalai Nagar 608002, Tamilnadu, India. Electronic address: jeyasundarligand@rediffmail.com.
authors: T
authors: T
authors: Jeyakumar
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D052117:Benzodioxoles / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004553:Electric Conductivity; D005658:Fungi / Q000187:drug effects; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008970:Molecular Weight; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013818:Thermogravimetry; D044366:Transition Temperature
chemical_list: C000593164:2-((E)-(benzo(d)(1,3)dioxol-6-ylimino)methyl)-6-ethoxyphenol; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000975:Antioxidants; D052117:Benzodioxoles; D056831:Coordination Complexes; D008024:Ligands; D010636:Phenols; D012545:Schiff Bases
keywords: 3,4-(Methylenedioxy)aniline; 3-Ethoxy salicylaldehyde; Schiff base metal complexes