title: Clinical characteristics of adenosquamous carcinoma of the pancreas: a matched case-control study.
abstract: OBJECTIVE
  Adenosquamous carcinoma of the pancreas (ASC) is a variant of pancreatic ductal adenocarcinoma (PDAC), but the prognosis remains unclear. The purpose of this study was to clarify the prognosis of ASC using a matched case-control design.
  
  
  METHODS
  We evaluated clinical characteristics of ASC treated between 2001 and 2011 in our institution. As controls, PDAC cases matched with ASC cases for sex, age, pretreatment Eastern Cooperative Oncology Group performance status, location, initial therapy and American Joint Committee on Cancer TNM staging for pancreatic cancer were also evaluated.
  
  
  RESULTS
  Of the 914 cases of pancreatic neoplasm, 28 cases (3.06%) of ASC were identified, and 56 cases of PDAC were matched as controls. Median overall survival (OS) was significantly worse for ASC (8.38 months) than for PDAC (15.75 months; hazard ratio [HR], 1.94; 95% confidence interval, 1.07-3.51; P = 0.026). Of the 22 unresected cases, median OS was again significantly worse for ASC (4.67 months) than for PDAC (12.36 months; HR, 2.39; 95% confidence interval, 1.27-4.51; P = 0.007).
  
  
  CONCLUSIONS
  These results demonstrate that ASC is more aggressive than PDAC.
authors: From the Departments of *Gastroenterology, †Gastroenterological Surgery, and ‡Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.
authors: Hiroshi
authors: H
authors: Imaoka
authors: Yasuhiro
authors: Y
authors: Shimizu
authors: Nobumasa
authors: N
authors: Mizuno
authors: Kazuo
authors: K
authors: Hara
authors: Susumu
authors: S
authors: Hijioka
authors: Masahiro
authors: M
authors: Tajika
authors: Shinya
authors: S
authors: Kondo
authors: Tsutomu
authors: T
authors: Tanaka
authors: Takeshi
authors: T
authors: Ogura
authors: Tomohiko
authors: T
authors: Obayashi
authors: Toshiyuki
authors: T
authors: Hasegawa
authors: Yasumasa
authors: Y
authors: Niwa
authors: Kenji
authors: K
authors: Yamao
mesh_terms: D000328:Adult; D000368:Aged; D018196:Carcinoma, Adenosquamous / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D016022:Case-Control Studies; D059248:Chemoradiotherapy / Q000379:methods; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care / Q000379:methods / Q000706:statistics & numerical data; D010190:Pancreatic Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D016016:Proportional Hazards Models