title: Ocular vestibular evoked myogenic potential frequency tuning in certain Menière's disease.
abstract: Ocular vestibular evoked myogenic potentials (oVEMP) represent extraocular muscle activity in response to vestibular stimulation. To specify the value of oVEMP in the diagnostics of Menière's disease, the amplitude ratio between 500 and 1000 Hz stimuli was investigated. Thirty-nine patients with certain Menière's disease, i.e. definite Menière's disease with visualization of endolymphatic hydrops by magnetic resonance imaging and 19 age-matched healthy controls were enrolled in this study. oVEMP were recorded using 500 and 1000 Hz air-conducted tone bursts. For Menière's ears, the 500/1000 Hz amplitude ratio (mean ratio = 1.20) was significantly smaller when compared to unaffected ears of Menière's patients (mean ratio = 1.80; p = 0.008) or healthy controls (mean ratio = 1.81; p = 0.011). The amplitude ratio was neither correlated with the degree of endolymphatic hydrops nor with the duration of disease. While an older age was associated with a diminished amplitude ratio in healthy controls, there was no correlation between the amplitude ratio and age in Menière's ears. Hence, the calculation of the oVEMP 500/1000 Hz amplitude ratio may be a valuable diagnostic tool for Menière's disease.
authors: German Center for Vertigo and Balance Disorders, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377 Munich, Germany. Electronic address: claudia.jerin@med.uni-muenchen.de.
authors: Claudia
authors: C
authors: Jerin
authors: German Center for Vertigo and Balance Disorders, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.
authors: Albert
authors: A
authors: Berman
authors: German Center for Vertigo and Balance Disorders, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377 Munich, Germany; Department of Otorhinolaryngology - Head and Neck Surgery, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.
authors: Eike
authors: E
authors: Krause
authors: Institute of Clinical Radiology, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.
authors: Birgit
authors: B
authors: Ertl-Wagner
authors: German Center for Vertigo and Balance Disorders, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377 Munich, Germany; Department of Otorhinolaryngology - Head and Neck Surgery, Grosshadern Medical Center, University of Munich, Marchioninistr. 15, 81377 Munich, Germany.
authors: Robert
authors: R
authors: Gürkov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology; D016022:Case-Control Studies; D018159:Endolymphatic Hydrops / Q000175:diagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis* / Q000503:physiopathology*; D008875:Middle Aged; D058585:Vestibular Evoked Myogenic Potentials; D055815:Young Adult
keywords: Frequency tuning; Menière's disease; Vestibular evoked myogenic potential; oVEMP