title: Carbonate hydroxyapatite functionalization: a comparative study towards (bio)molecules fixation.
abstract: Different methods for the functionalization of carbonate hydroxyapatite granules with free amine groups by reaction with (3-aminopropyl)triethoxysilane (APTES) have been compared in order to improve the potential for tethering of bioactive molecules to bioceramics. The combined use of tetraethoxyorthosilicate and APTES with acid catalysis resulted in an evident increase in amine surface grafting.
authors: Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza 2, Milano 20126 , Italy.
authors: Laura
authors: L
authors: Russo
authors: Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza 2, Milano 20126 , Italy.
authors: Francesca
authors: F
authors: Taraballi
authors: Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza 2, Milano 20126 , Italy.
authors: Cristina
authors: C
authors: Lupo
authors: Servicio Interdepartamental de Investigación , University Autonoma of Madrid , Madrid 28049 , Spain.
authors: Ana
authors: A
authors: Poveda
authors: Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza 2, Milano 20126 , Italy ; Department of Chemical and Phisical Biology , Centro de Invesigaciones Biológicas, CSIC , Ramiro de Maeztu 9, Madrid 28040 , Spain.
authors: Jesús
authors: J
authors: Jiménez-Barbero
authors: Institute of Science and Technology for Ceramics - National Research Council of Italy (ISTEC-CNR) , Via Granarolo, 64, Faenza, Ravenna 48018 , Italy.
authors: Monica
authors: M
authors: Sandri
authors: Institute of Science and Technology for Ceramics - National Research Council of Italy (ISTEC-CNR) , Via Granarolo, 64, Faenza, Ravenna 48018 , Italy.
authors: Anna
authors: A
authors: Tampieri
authors: Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza 2, Milano 20126 , Italy.
authors: Francesco
authors: F
authors: Nicotra
authors: Department of Biotechnology and Biosciences , University of Milano-Bicocca , Piazza della Scienza 2, Milano 20126 , Italy.
authors: Laura
authors: L
authors: Cipolla
keywords: APTES; NMR; bioceramics; carbonate hydroxyapatite; covalent functionalization; sol–gel