title: Association between postprandial triglycerides and coronary artery disease detected by coronary computed tomography angiography.
abstract: BACKGROUND
  Studies have demonstrated the association of severe anatomical coronary artery disease (CAD) with postprandial triglycerides (TG) concentrations. Nevertheless the relationship between less severe atherosclerosis plaque burden and postprandial TG is less established.
  
  
  OBJECTIVE
  to study the relationship between postprandial TG and CAD detected by coronary computed tomographic angiography (CTA).
  
  
  METHODS
  130 patients who underwent an oral fat tolerance test were enrolled (85 with CAD detected by CTA and 45 without). Postprandial lipemia was studied by measuring TG from T0h to T6h with 2-h intervals, and analyzed the TG change over time using a longitudinal multivariable linear mixed effects model with the log normal of the TG as the primary outcome.
  
  
  RESULTS
  The majority of individuals with CAD had non-obstructive disease (63.3%) Patients with CAD had a slower clearance of postprandial TG change from 4 h to 6 h (p<0.05) compared to patients without CAD. These results remained significant after adjustment for fasting TG and glucose, age, gender, body mass index, and waist circumference. However, those differences did not reach statistical significance after adjustment for fasting HDL-C.
  
  
  CONCLUSIONS
  Patients with mild (<25% lumen obstruction) and moderate CAD (25-50% lumen obstruction) detected by coronary CTA had an impaired postprandial metabolism, with a delayed TG clearance, when compared to individuals with no CAD. This difference was partially explained by the lower HDL-C. Thus, though postprandial TG may contribute to the development of CAD, this association is partially related to low HDL-C.
authors: Hospital Universitário, University of São Paulo, São Paulo, Brazil; Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.
authors: Henrique L
authors: HL
authors: Staniak
authors: Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.
authors: Wilson
authors: W
authors: Salgado Filho
authors: Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.
authors: Márcio H
authors: MH
authors: Miname
authors: Hospital Universitário, University of São Paulo, São Paulo, Brazil.
authors: Isabela M
authors: IM
authors: Benseñor
authors: Hospital Universitário, University of São Paulo, São Paulo, Brazil.
authors: Paulo A
authors: PA
authors: Lotufo
authors: Hospital Universitário, University of São Paulo, São Paulo, Brazil.
authors: Rodolfo
authors: R
authors: Sharovsky
authors: Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.
authors: Carlos E
authors: CE
authors: Rochitte
authors: Hospital Universitário, University of São Paulo, São Paulo, Brazil.
authors: Márcio S
authors: MS
authors: Bittencourt
authors: Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil. Electronic address: rdsf@uol.com.br.
authors: Raul D
authors: RD
authors: Santos
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D001786:Blood Glucose / Q000032:analysis; D002114:Calcinosis / Q000097:blood / Q000000981:diagnostic imaging; D008076:Cholesterol, HDL / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging; D023921:Coronary Stenosis / Q000097:blood / Q000000981:diagnostic imaging; D004041:Dietary Fats / Q000493:pharmacokinetics; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000097:blood / Q000000981:diagnostic imaging; D019518:Postprandial Period / Q000502:physiology*; D012907:Smoking / Q000097:blood; D014057:Tomography, X-Ray Computed; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D004041:Dietary Fats; D014280:Triglycerides
keywords: Atherosclerosis; Coronary computed tomography angiography; Postprandial lipemia; Triglycerides