title: Excellent outcomes for adolescents and adults with acute lymphoblastic leukemia and lymphoma without allogeneic stem cell transplant: the FRALLE-93 pediatric protocol.
abstract: Adolescents and adults with acute lymphoblastic leukemia/lymphoma (ALL) have better outcomes when treated using pediatric protocols compared with treatment using adult protocols. We reviewed the progress and outcomes of 40 adolescents and adults up to 45 years of age, from three Australian centers, treated on the intensive French group for childhood ALL (FRALLE)-93 pediatric protocol. All except one patient achieved a morphologic complete remission following induction chemotherapy. Three-year overall survival for all-risk and standard-risk disease was 70% and 75%, respectively. The treatment protocol was generally well tolerated with no treatment related mortality. The FRALLE-93 pediatric protocol showed excellent overall survival for patients with standard-risk disease, without the need for allogeneic hematopoietic stem cell transplant in first remission.
authors: Box Hill Hospital , Box Hill , Australia.
authors: Jay
authors: J
authors: Hocking
authors: Anthony P
authors: AP
authors: Schwarer
authors: Robin
authors: R
authors: Gasiorowski
authors: Sush
authors: S
authors: Patil
authors: Sharon
authors: S
authors: Avery
authors: John
authors: J
authors: Gibson
authors: Harry
authors: H
authors: Iland
authors: P Joy
authors: PJ
authors: Ho
authors: Douglas
authors: D
authors: Joshua
authors: Jenny
authors: J
authors: Muirhead
authors: Hock
authors: H
authors: Lai
authors: Ian
authors: I
authors: Irving
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D060830:Consolidation Chemotherapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D060828:Induction Chemotherapy; D060046:Maintenance Chemotherapy; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy*; D012307:Risk Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult
keywords: Acute lymphoblastic leukemia; adults; chemotherapy protocol; disease risk; overall survival