title: [Blueberry Muffin Baby and Langerhans' congenital cell histiocytosis].
abstract: BACKGROUND
  Blueberry Muffin Baby is a rare neonatal cutaneous syndrome for purpuric lesions reflective of extramedullary hematopoiesis. Many causes are known, examples are congenital infections, malignancy and hematologic disorders. Langerhans' cell histiocytosis is a clonal proliferation of dendritic histiocytes. This has very rarely been associated with a Blueberry Muffin Baby presentation.
  
  
  METHODS
  We report the case of a newborn presenting with Blueberry Muffin Baby syndrome related to congenital Langherans' cell histiocytosis. At birth, he had multiple purpuric lesions on the trunk, limbs and face. Skin biopsy showed a dermal proliferation of histiocytes staining positive for S100 and CD1a. Chest and bone radiographs, and abdominal ultrasound were normal. Skin lesions have resolved in 8 weeks, the patient is in complete remission at 18 months of follow-up.
  
  
  CONCLUSIONS
  A Blueberry Muffin Baby syndrome may reveal neonatal Langerhans' histiocytosis.
authors: Service de dermatologie, hôpital Saint-Vincent-de-Paul, université catholique de Lille, boulevard de Belfort, 59020 Lille, France. Electronic address: lasek.audrey@ghicl.net.
authors: A
authors: A
authors: Lasek-Duriez
authors: Service de néonatalogie, hôpital Saint-Vincent-de-Paul, université catholique de Lille, boulevard de Belfort, 59020 Lille, France.
authors: M-L
authors: ML
authors: Charkaluk
authors: Service d'anatomopathologie, hôpital Saint-Vincent-de-Paul, université catholique de Lille, boulevard de Belfort, 59020 Lille, France.
authors: P
authors: P
authors: Gosset
authors: Service de dermatologie, hôpital Saint-Vincent-de-Paul, université catholique de Lille, boulevard de Belfort, 59020 Lille, France.
authors: P
authors: P
authors: Modiano
mesh_terms: D018949:Antigens, CD1 / Q000032:analysis; D006411:Hematopoiesis, Extramedullary; D006644:Histiocytes / Q000737:chemistry / Q000473:pathology; D006646:Histiocytosis, Langerhans-Cell / Q000151:congenital* / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012075:Remission, Spontaneous; D009418:S100 Proteins / Q000032:analysis; D012867:Skin / Q000737:chemistry / Q000473:pathology; D013577:Syndrome
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen; D009418:S100 Proteins
keywords: Blueberry Muffin Baby; Hashimoto-Pritzker; Histiocytose langerhansienne; Langerhans’ cells histiocytosis; Newborn; Nodules; Nouveau-né; Rémission spontanée; Spontaneous remission