title: [Array comparative genomic hybridization detection of a de novo 4q21.21-q22.1 deletion in a child with severe growth retardation].
abstract: OBJECTIVE
  To analyze a child with developmental delay, severe mental retardation, speech delay and muscular hypotonia.
  
  
  METHODS
  The karotypes of the child and her parents were analyzed with G-banding analysis. Their genome DNA was also analyzed with array comparative genomic hybridization (array-CGH).
  
  
  RESULTS
  No karyotypic abnormality was detected at cytogenetic level. However, array-CGH has identified a de novo 4q21.21-q22.1 deletion in the child, which has a size of 12.1 Mb.
  
  
  CONCLUSIONS
  The de novo interstitial 4q21.21-q22.1 deletion probably underlies the main clinical manifestation in the child. Array-CGH is useful for diagnosing children with multiple congenital anomalies with unclear etiology.
authors: Center of Prenatal Diagnosis, Nanjing Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210004, P.R.China. njxzf@126.com; njfybjyhuping@163.com.
authors: Jing
authors: J
authors: Zhou
authors: Ping
authors: P
authors: Hu
authors: An
authors: A
authors: Liu
authors: Li
authors: L
authors: Li
authors: Xiuqing
authors: X
authors: Ji
authors: Weirong
authors: W
authors: Hui
authors: Yan
authors: Y
authors: Wang
authors: Zhengfeng
authors: Z
authors: Xu
mesh_terms: D002675:Child, Preschool; D002894:Chromosomes, Human, Pair 4; D055028:Comparative Genomic Hybridization / Q000379:methods; D005260:Female; D017353:Gene Deletion; D006130:Growth Disorders / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000175:diagnosis / Q000235:genetics*; D017384:Sequence Deletion