title: Treatment of pruritus in early-stage hypopigmented mycosis fungoides with aprepitant.
abstract: Pruritus is a symptom that significantly affects the patient's quality of life in cutaneous T cell lymphoma (CTCL). The most effective treatments are those that address the condition itself; however, it is often not possible to control this symptom. Lymphoma-related pruritus normally becomes more severe as CTCL progresses, constituting an important factor for quality of life in these patients. Substance P is a neuromodulator which appears to play a key role in pruritus. Aprepitant is a neurokinin-1 receptor antagonist affecting the substance P receptor. So far, several cases have been documented with an antipruritic response to the drug aprepitant in advanced-stage mycosis fungoides (MF). In this paper, we describe an excellent response to aprepitant in a female patient with severe pruritus secondary to hypopigmented stage I MF. We would also like to stress the absence of nausea and vomiting of this combined therapy of interferon and aprepitant. Aprepitant could improve tolerance to interferon.
authors: Department of Dermatology, Puerta del Mar University Hospital, Cadiz, Spain.
authors: David
authors: D
authors: Jiménez Gallo
authors: Cristina
authors: C
authors: Albarrán Planelles
authors: Mario
authors: M
authors: Linares Barrios
authors: María José
authors: MJ
authors: Fernández Anguita
authors: Juan
authors: J
authors: Márquez Enríquez
authors: María Eugenia
authors: ME
authors: Rodríguez Mateos
mesh_terms: D000328:Adult; D000982:Antipruritics / Q000627:therapeutic use*; D000077608:Aprepitant; D005260:Female; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology*; D009025:Morpholines / Q000627:therapeutic use*; D009182:Mycosis Fungoides / Q000150:complications* / Q000473:pathology; D009367:Neoplasm Staging; D064729:Neurokinin-1 Receptor Antagonists / Q000627:therapeutic use*; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D012878:Skin Neoplasms / Q000150:complications* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000982:Antipruritics; D009025:Morpholines; D064729:Neurokinin-1 Receptor Antagonists; D000077608:Aprepitant
keywords: aprepitant; mycosis fungoides; pruritus