title: Total synthesis of resveratrol-based natural products using a palladium-catalyzed decarboxylative arylation and an oxidative Heck reaction.
abstract: Controlled access to resveratrol-based natural products is offered by a novel, modular concept. A common building block readily available on a large scale serves as the starting material for the introduction of structurally important aryl groups by a Pd-catalyzed decarboxylative arylation and an oxidative Heck reaction with good yields and high stereoselectivity. The modular approach is convincingly documented by the successful synthesis of three racemic resveratrol-based natural products (quadrangularin A, ampelopsin D, and pallidol).
authors: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Correnstrasse 40, 48149 Münster (Germany).
authors: Felix
authors: F
authors: Klotter
authors: Armido
authors: A
authors: Studer
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003653:Decarboxylation; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D000077185:Resveratrol; D013237:Stereoisomerism; D013267:Stilbenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D013267:Stilbenes; D010165:Palladium; D000077185:Resveratrol
keywords: decarboxylative coupling; natural products; palladium; resveratrol; total synthesis