title: Prediction of acute pancreatitis risk based on PIP score in children with cystic fibrosis.
abstract: BACKGROUND
  Currently no tools to predict risk of acute (AP) and recurrent pancreatitis (ARP) in children with cystic fibrosis (CF) are available. We assessed the prevalence of AP/ARP and tested the potential role of Pancreatic Insufficiency Prevalence (PIP) score in a cohort of children with CF.
  
  
  METHODS
  We identified two groups of children, on the basis of presence/absence of AP/ARP, who were compared for age at diagnosis, clinical features, genotypes and sweat chloride level. PIP score was calculated for each patient.
  
  
  RESULTS
  10/167 (5.9%) experienced at least one episode of AP during follow up; 10/10 were pancreatic sufficient (PS). Patients with AP/ARP showed a PIP score ≤0.25 more frequently (6/10) than patients without AP/ARP. The odds ratio (95% CI) of developing pancreatitis was 4.54 (1.22-16.92) for patients with PIP <0.25 when compared with those who have a PIP score >0.25 (p 0.0151). PIP score was correlated with sweat chloride test (p < 0.01).
  
  
  CONCLUSIONS
  PIP score, PS status and normal/borderline sweat chloride levels could be applied to predict pancreatitis development in children with CF. ARP could lead to pancreatic insufficiency.
authors: Department of Translational Medical Sciences, University of Naples Federico II, Italy.
authors: V
authors: V
authors: Terlizzi
authors: Department of Translational Medical Sciences, University of Naples Federico II, Italy.
authors: A
authors: A
authors: Tosco
authors: CEINGE-Advanced Biotechnology, Naples, Italy; Department of Biochemistry and Biotechnology, University of Naples Federico II, Italy.
authors: R
authors: R
authors: Tomaiuolo
authors: Department of Translational Medical Sciences, University of Naples Federico II, Italy.
authors: A
authors: A
authors: Sepe
authors: Department of Translational Medical Sciences, University of Naples Federico II, Italy.
authors: N
authors: N
authors: Amato
authors: Department of Translational Medical Sciences, University of Naples Federico II, Italy.
authors: A
authors: A
authors: Casale
authors: Department of Translational Medical Sciences, University of Naples Federico II, Italy.
authors: C
authors: C
authors: Mercogliano
authors: Department of Translational Medical Sciences, University of Naples Federico II, Italy.
authors: F
authors: F
authors: De Gregorio
authors: Department of Translational Medical Sciences, University of Naples Federico II, Italy.
authors: F
authors: F
authors: Improta
authors: CEINGE-Advanced Biotechnology, Naples, Italy; Department of Biochemistry and Biotechnology, University of Naples Federico II, Italy.
authors: A
authors: A
authors: Elce
authors: CEINGE-Advanced Biotechnology, Naples, Italy; Department of Biochemistry and Biotechnology, University of Naples Federico II, Italy.
authors: G
authors: G
authors: Castaldo
authors: Department of Translational Medical Sciences, University of Naples Federico II, Italy. Electronic address: raia@unina.it.
authors: V
authors: V
authors: Raia
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications / Q000503:physiopathology*; D005260:Female; D005544:Forecasting; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010195:Pancreatitis / Q000209:etiology*; D012008:Recurrence; D012306:Risk
keywords: Children; Cystic fibrosis; PIP score; Pancreatitis