title: Interim estimates of 2013/14 vaccine effectiveness against influenza A(H1N1)pdm09 from Canada s sentinel surveillance network, January 2014.
abstract: The 2013/14 influenza season to date in Canada has been characterised by predominant (90%) A(H1N1)pdm09 activity. Vaccine effectiveness (VE) was assessed in January 2014 by Canada's sentinel surveillance network using a test-negative case-control design. Interim adjusted-VE against medically-attended laboratory-confirmed influenza A(H1N1)pdm09 infection was 74% (95% CI: 58-83). Relative to vaccine, A(H1N1)pdm09 viruses were antigenically similar and genetically well conserved, with most showing just three mutations across the 50 amino acids comprising antigenic sites of the haemagglutinin protein.
authors: British Columbia Centre for Disease Control, Vancouver, Canada.
authors: Dm
authors: D
authors: Skowronski
authors: C
authors: C
authors: Chambers
authors: S
authors: S
authors: Sabaiduc
authors: G
authors: G
authors: De Serres
authors: Ja
authors: J
authors: Dickinson
authors: Al
authors: A
authors: Winter
authors: K
authors: K
authors: Fonseca
authors: Jb
authors: J
authors: Gubbay
authors: H
authors: H
authors: Charest
authors: M
authors: M
authors: Petric
authors: M
authors: M
authors: Krajden
authors: Sm
authors: S
authors: Mahmud
authors: P
authors: P
authors: Van Caeseele
authors: Tl
authors: T
authors: Kwindt
authors: A
authors: A
authors: Eshaghi
authors: N
authors: N
authors: Bastien
authors: Y
authors: Y
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D007251:Influenza, Human / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control* / Q000821:virology; D009305:Nasopharynx / Q000821:virology; D009666:Nose / Q000821:virology; D017063:Outcome Assessment, Health Care; D060888:Real-Time Polymerase Chain Reaction; D012621:Seasons; D012680:Sensitivity and Specificity; D018571:Sentinel Surveillance; D017422:Sequence Analysis, DNA; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D007252:Influenza Vaccines