title: (10)B-NMR determination of (10)B-BPA, (10)B-BPA-fructose complex and total (10)B in blood for BNCT.
abstract: First spontaneous, noninvasive determination method of (10)B-BPA, (10)B-BPA-fructose complex, and total (10)B in blood is described. (10)B-NMR measurement with 100,000 FT accumulation enables us to obtain the result within 100min/sample. The detection limits for the simultaneous analysis were 3ppm, 3ppm and 6ppm for (10)B-BPA, (10)B-BPA-fructose complex and total (10)B respectively in this study. By this method, we can actually discuss behavior of the (10)B-BPA-fructose complex in blood.
authors: Department of Chemistry, Faculty of Science, Shinshu University, Asahi, Matsumoto, Nagano 390-8621, Japan. Electronic address: yoshino@shinshu-u.ac.jp.
authors: K
authors: K
authors: Yoshino
authors: Department of Chemistry, Faculty of Science, Shinshu University, Asahi, Matsumoto, Nagano 390-8621, Japan.
authors: T
authors: T
authors: Yabe
authors: Department of Chemistry, Faculty of Science, Shinshu University, Asahi, Matsumoto, Nagano 390-8621, Japan.
authors: T
authors: T
authors: Hattori
authors: Department of Chemistry, Faculty of Science, Shinshu University, Asahi, Matsumoto, Nagano 390-8621, Japan.
authors: K
authors: K
authors: Saito
authors: Department of Chemistry, Faculty of Science, Shinshu University, Asahi, Matsumoto, Nagano 390-8621, Japan.
authors: A
authors: A
authors: Ishikawa
authors: Department of Chemistry, Faculty of Science, Shinshu University, Asahi, Matsumoto, Nagano 390-8621, Japan.
authors: H
authors: H
authors: Ohki
mesh_terms: D001774:Blood Chemical Analysis / Q000379:methods*; D001895:Boron / Q000097:blood*; D001896:Boron Compounds / Q000097:blood*; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D005632:Fructose / Q000097:blood* / Q000737:chemistry; D006801:Humans; D007554:Isotopes / Q000097:blood; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000097:blood; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D001896:Boron Compounds; D007554:Isotopes; D005632:Fructose; D010649:Phenylalanine; D001895:Boron; C033685:4-boronophenylalanine
keywords: (10)B-NMR; (10)B-analysis; BNCT; BPA; BPA–fructose complex; Red cell components (RCC)