title: From arrest to escape: HIV-1 Vpr cuts a deal.
abstract: HIV Vpr induces a cell-cycle arrest at the G2-to-M transition through a poorly understood mechanism. In a recent issue of Cell, Laguette et al. (2014) demonstrate that untimely activation of the structure-specific endonuclease regulator SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing.
authors: Laboratory of Human Retrovirology, Institut de Recherches Cliniques de Montréal (IRCM) and Department of Microbiology, Infectiology and Immunology, Université de Montréal, Montreal, QC H2W 1R7, Canada. Electronic address: eric.cohen@ircm.qc.ca.
authors: Eric A
authors: EA
authors: Cohen
mesh_terms: D059565:G2 Phase Cell Cycle Checkpoints; D015658:HIV Infections / Q000473:pathology*; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D046912:Multiprotein Complexes / Q000378:metabolism*; D045522:Recombinases / Q000378:metabolism*; D054325:vpr Gene Products, Human Immunodeficiency Virus / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D045522:Recombinases; D054325:vpr Gene Products, Human Immunodeficiency Virus