title: Surgical outcomes in the management of isolated nodal recurrences: a multicenter, international retrospective cohort.
abstract: OBJECTIVE
  We report a multicenter international cohort representing what is to our knowledge the largest surgical experience with managing isolated retroperitoneal nodal recurrence of renal cell carcinoma, a unique subset of locoregional disease, yet to be described in detail.
  
  
  METHODS
  Patients with isolated nodal recurrence of pTanyN+M0 disease after nephrectomy were identified by retrospective chart review at 3 independent institutions. Progression-free survival was estimated by the Kaplan-Meier method and used to compare survival outcomes between primary T(1-2)N(any)M0 and T3N(any)M0 tumors as well as clear cell and nonclear cell histology renal cell carcinoma.
  
  
  RESULTS
  A total of 22 patients met study inclusion criteria. Median time to local postoperative recurrence was 31.5 months (IQR 12.9-43.3). After resection of isolated nodal recurrence 10 patients (46%) had a secondary recurrence at a median of 11.2 months (IQR 8.1-18.4), of whom 2 (9%) died of the disease. Overall median progression-free survival was 12.7 months, including 24.8 months for T(1-2)N(any)M0 tumors, 9.9 months for T3N(any)M0 tumors, and 13.4 and 17.6 months for clear and nonclear cell renal cell carcinoma, respectively.
  
  
  CONCLUSIONS
  Surgical resection represents the best curative option for patients who present with isolated retroperitoneal lymph node recurrence of renal cell carcinoma. Durable postoperative progression-free survival is attainable in many patients regardless of histology or clinical TNM stage. In addition, our cohort showed a lower renal cell carcinoma related mortality rate than in previous series of local metastasis. As such, all patients free of precluding comorbidities should be considered candidates for complete surgical resection performed by an experienced genitourinary surgeon.
authors: Morsani College of Medicine, University of South Florida, Tampa, Florida.
authors: Christopher M
authors: CM
authors: Russell
authors: H. Lee Moffitt Cancer Center, Tampa, Florida.
authors: Patrick N
authors: PN
authors: Espiritu
authors: McGill University, Montreal, Quebec, Canada.
authors: Wassim
authors: W
authors: Kassouf
authors: Roswell Park Cancer Institute, Buffalo, New York.
authors: Thomas
authors: T
authors: Schwaab
authors: H. Lee Moffitt Cancer Center, Tampa, Florida.
authors: David D
authors: DD
authors: Buethe
authors: H. Lee Moffitt Cancer Center, Tampa, Florida.
authors: Jasreman
authors: J
authors: Dhilon
authors: H. Lee Moffitt Cancer Center, Tampa, Florida.
authors: Wade J
authors: WJ
authors: Sexton
authors: H. Lee Moffitt Cancer Center, Tampa, Florida.
authors: Michael
authors: M
authors: Poch
authors: H. Lee Moffitt Cancer Center, Tampa, Florida.
authors: Julio M
authors: JM
authors: Powsang
authors: McGill University, Montreal, Quebec, Canada.
authors: Simon
authors: S
authors: Tanguay
authors: McGill University, Montreal, Quebec, Canada.
authors: Madhur
authors: M
authors: Nayan
authors: McGill University, Montreal, Quebec, Canada.
authors: Hazem
authors: H
authors: Alsaadi
authors: Roswell Park Cancer Institute, Buffalo, New York.
authors: Michael I
authors: MI
authors: Hanzly
authors: H. Lee Moffitt Cancer Center, Tampa, Florida. Electronic address: philippe.spiess@moffitt.org.
authors: Philippe E
authors: PE
authors: Spiess
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000601:surgery*; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D009392:Nephrectomy; D012186:Retroperitoneal Neoplasms / Q000601:surgery*; D012189:Retrospective Studies
keywords: carcinoma; kidney; lymph node excision; nephrectomy; recurrence; renal cell