title: [Lipid peroxidation and the response of the antioxidant defense system in the obese type 2 diabetic compared with the non-obese type 2 diabetic].
abstract: BACKGROUND
  Diabetes is associated with increased lipid peroxidation, quantified as the levels of thiobarbituric acid reactive substances (TBARS). In parallel, the antioxidant defense system (ADS) reacts to diminish the oxidative damage.
  
  
  OBJECTIVE
  To determine the levels of lipid peroxidation and the activity of antioxidant enzymes in obese type 2 diabetic (DM2) individuals compared to non-obese DM2 individuals.
  
  
  METHODS
  Lipid peroxidation was quantified by measuring TBARS and the ADS response by measuring the activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx).
  
  
  RESULTS
  Two groups of 30 subjects were studied. The obese DM2 group had a mean body mass index (BMI) 38.6 ± 3.5 kg m(-2) compared to the control group 24.7 ± 3.6 kg m(-2) (p<0.01). TBARS levels in the study group were higher compared to the control group (p <0.01). Multiple linear regression analysis suggested that activities of SOD and CAT adjusted to lipid peroxidation (TBARS) in the obese DM2 individuals.
  
  
  CONCLUSIONS
  TBARS levels suggest greater oxidative damage in obese DM2 subjects with a diminished response of ADS.
authors: Centro de Investigaciones Biológicas del Noroeste (CIBNOR). Planeación Ambiental y Conservación. La Paz. Baja California Sur. México. Hospital General de Zona N.º 1. Instituto Mexicano del Seguro Social. La Paz. Baja California Sur. México.. r.gaxiolar@gmail.com.
authors: Ramón
authors: R
authors: Gaxiola-Robles
authors: Centro de Investigación Biomédica de Occidente (CIBO). Instituto Mexicano del Seguro Social. Guadalajara. Jalisco. México..
authors: Oscar Kurt
authors: OK
authors: Bitzer-Quintero
authors: Centro de Investigaciones Biológicas del Noroeste (CIBNOR). Planeación Ambiental y Conservación. La Paz. Baja California Sur. México..
authors: Lía Celina
authors: LC
authors: Méndez-Rodríguez
authors: Centro de Investigaciones Biológicas del Noroeste (CIBNOR). Planeación Ambiental y Conservación. La Paz. Baja California Sur. México..
authors: Vanessa
authors: V
authors: Labrada-Martagón
authors: Hospital General de Zona N.º 1. Instituto Mexicano del Seguro Social. La Paz. Baja California Sur. México..
authors: Adolfo
authors: A
authors: García-González
authors: Centro de Investigación Biomédica de Occidente (CIBO). Instituto Mexicano del Seguro Social. Guadalajara. Jalisco. México..
authors: Luis Javier
authors: LJ
authors: Ramírez-Jirano
authors: Centro de Investigaciones Biológicas del Noroeste (CIBNOR). Planeación Ambiental y Conservación. La Paz. Baja California Sur. México..
authors: Marcela
authors: M
authors: Veléz-Alavez
authors: Centro de Investigaciones Biológicas del Noroeste (CIBNOR). Planeación Ambiental y Conservación. La Paz. Baja California Sur. México.. tzenteno04@cibnor.mx.
authors: Tania
authors: T
authors: Zenteno-Savín
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D009765:Obesity / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances