title: Point-of-care technologies for molecular diagnostics using a drop of blood.
abstract: Molecular diagnostics is crucial for prevention, identification, and treatment of disease. Traditional technologies for molecular diagnostics using blood are limited to laboratory use because they rely on sample purification and sophisticated instruments, are labor and time intensive, expensive, and require highly trained operators. This review discusses the frontiers of point-of-care (POC) diagnostic technologies using a drop of blood obtained from a finger prick. These technologies, including emerging biotechnologies, nanotechnologies, and microfluidics, hold the potential for rapid, accurate, and inexpensive disease diagnostics.
authors: Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA.
authors: Yujun
authors: Y
authors: Song
authors: Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78758, USA.
authors: Yu-Yen
authors: YY
authors: Huang
authors: Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA.
authors: Xuewu
authors: X
authors: Liu
authors: Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78758, USA.
authors: Xiaojing
authors: X
authors: Zhang
authors: Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA.
authors: Mauro
authors: M
authors: Ferrari
authors: Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address: Lqin@HoustonMethodist.org.
authors: Lidong
authors: L
authors: Qin
mesh_terms: D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000379:methods* / Q000639:trends; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D019095:Point-of-Care Systems / Q000639:trends*
chemical_list: D015415:Biomarkers
keywords: biomolecules; circulating tumor cells; molecular diagnostics; nucleic acids; point-of-care diagnostics; proteins