title: Persistent homological sparse network approach to detecting white matter abnormality in maltreated children: MRI and DTI multimodal study.
abstract: We present a novel persistent homological sparse network analysis framework for characterizing white matter abnormalities in tensor-based morphometry (TBM) in magnetic resonance imaging (MRI). Traditionally TBM is used in quantifying tissue volume change in each voxel in a massive univariate fashion. However, this obvious approach cannot be used in testing, for instance, if the change in one voxel is related to other voxels. To address this limitation of univariate-TBM, we propose a new persistent homological approach to testing more complex relational hypotheses across brain regions. The proposed methods are applied to characterize abnormal white matter in maltreated children. The results are further validated using fractional anisotropy (FA) values in diffusion tensor imaging (DTI).
authors: University of Wisconsin-Madison, USA. mkchung@wisc.edu
authors: Moo K
authors: MK
authors: Chung
authors: University of Wisconsin-Madison, USA.
authors: Jamie L
authors: JL
authors: Hanson
authors: Seoul National University, Korea.
authors: Hyekyoung
authors: H
authors: Lee
authors: University of Wisconsin-Madison, USA.
authors: Nagesh
authors: N
authors: Adluru
authors: University of Wisconsin-Madison, USA.
authors: Andrew L
authors: AL
authors: Alexander
authors: University of Wisconsin-Madison, USA.
authors: Richard J
authors: RJ
authors: Davidson
authors: University of Wisconsin-Madison, USA.
authors: Seth D
authors: SD
authors: Pollak
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology*; D002648:Child; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D038642:Shaken Baby Syndrome / Q000473:pathology*