title: Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study.
abstract: Although beta-amyloid, anxiety and depression have linked cross-sectionally to reduced memory function in healthy older adults without dementia, prospective data evaluating these associations are lacking. Using data an observational cohort study of 178 healthy older adults without dementia followed for 3 years, we found that anxiety symptoms significantly moderated the relationship between beta-amyloid level and decline in verbal (Cohen's d = 0.65) and episodic (Cohen's d = 0.38) memory. Anxiety symptoms were additionally linked to greater decline in executive function, irrespective of beta-amyloid and other risk factors. These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid.
authors: Robert H. Pietrzak, PhD, MPH, J. Cobb Scott, PhD, United States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven and Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA; Alexander Neumeister, MD, Departments of Psychiatry and Radiology, New York University School of Medicine, New York, USA; Yen Ying Lim, PhD, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; David Ames, MD, Academic Unit for Psychiatry of Old Age, St Vincent's Health, Department of Psychiatry, The University of Melbourne, Kew and National Ageing Research Institute, Parkville, Victoria, Australia; Kathryn A. Ellis, PhD, The Florey Institute of Neuroscience and Mental Health, Parkville, Academic Unit for Psychiatry of Old Age, St Vincent's Health, Department of Psychiatry, The University of Melbourne, Kew and National Ageing Research Institute, Parkville, Victoria, Australia; Karra Harrington, BA, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Nicola T. Lautenschlager, MD, Academic Unit for Psychiatry of Old Age, St Vincent's Health, Department of Psychiatry, The University of Melbourne, Kew, Victoria and School of Psychiatry and Clinical Neurosciences and WA Centre for Health & Ageing, The University of Western Australia, Perth, Australia; Cassandra Szoeke, MD, National Ageing Research Institute, Parkville, Mental Health Research Institute, The University of Melbourne, Parkville and CSIRO Preventative Health Flagship, Parkville, Victoria, Australia; Ralph N. Martins, PhD, Centre of Excellence for Alzheimer's Disease Research and Care, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia; Colin L. Masters, MD, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia; Victor L. Villemagne, MD, The Flor
authors: Robert H
authors: RH
authors: Pietrzak
authors: J Cobb
authors: JC
authors: Scott
authors: Alexander
authors: A
authors: Neumeister
authors: Yen Ying
authors: YY
authors: Lim
authors: David
authors: D
authors: Ames
authors: Kathryn A
authors: KA
authors: Ellis
authors: Karra
authors: K
authors: Harrington
authors: Nicola T
authors: NT
authors: Lautenschlager
authors: Cassandra
authors: C
authors: Szoeke
authors: Ralph N
authors: RN
authors: Martins
authors: Colin L
authors: CL
authors: Masters
authors: Victor L
authors: VL
authors: Villemagne
authors: Christopher C
authors: CC
authors: Rowe
authors: Paul
authors: P
authors: Maruff
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism / Q000523:psychology*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001007:Anxiety / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D015331:Cohort Studies; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000175:diagnosis* / Q000378:metabolism / Q000523:psychology; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging
chemical_list: D016229:Amyloid beta-Peptides