title: Influence of diabetes and diabetes type on anatomic and visual outcomes following central rein vein occlusion.
abstract: OBJECTIVE
  To determine the influence of diabetes and diabetes type on ocular outcomes following central retinal vein occlusion (CRVO).
  
  
  METHODS
  Retrospective chart review of all patients evaluated over a 4-year period in a tertiary diabetes eye care center. Ophthalmic findings were recorded including visual acuity and the presence of retinal neovascularization at presentation, after 3-6 months, and at last follow-up.
  
  
  RESULTS
  The records of 19,648 patients (13,571 diabetic; 6077 nondiabetic) were reviewed. The prevalence of CRVO in diabetic patients (N=72) and nondiabetic patients (N=27) were 0.5 and 0.4%, respectively. Disc neovascularization (21.3 vs 0.0%, P=0.05) and panretinal photocoagulation (PRP) (48.7 vs 21.4%, P=0.01) were more common in diabetic patients compared with nondiabetic patients. Compared with type 2 diabetic patients, retinal neovascularization (28.6 vs 3.7%, P=0.004) and subsequent PRP (78.6 vs 41.9%, P=0.01) were more likely in type 1 patients. Optic nerve head collateral vessels (CVs) were observed less than half as often (21.4 vs 56.5%, P=0.04) in patients with type 1 diabetes. Presence of optic nerve head CVs at baseline was associated with less likelihood of PRP (14.3 vs 46.1%, P=0.03).
  
  
  CONCLUSIONS
  In this cohort, the rates of CRVO in diabetic and nondiabetic patients were similar to previously published population-based studies. Following CRVO, diabetic patients had higher rates of disc neovascularization and were more likely to require subsequent PRP than nondiabetic patients. As compared with CRVO patients with type 2 diabetes, patients with type 1 diabetes and CRVO had worse anatomic outcomes with substantially increased risks of retinal neovascularization and PRP; however, final visual acuity outcomes were similar.
authors: Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
authors: J G
authors: JG
authors: Santiago
authors: Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
authors: S
authors: S
authors: Walia
authors: 1] Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA [2] Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
authors: J K
authors: JK
authors: Sun
authors: 1] Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA [2] Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
authors: J D
authors: JD
authors: Cavallerano
authors: Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
authors: Z A
authors: ZA
authors: Haddad
authors: 1] Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA [2] Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
authors: L P
authors: LP
authors: Aiello
authors: 1] Beetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA [2] Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
authors: P S
authors: PS
authors: Silva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D005451:Fluorescein Angiography; D005902:Glaucoma, Open-Angle / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D015861:Retinal Neovascularization / Q000503:physiopathology*; D012170:Retinal Vein Occlusion / Q000503:physiopathology*; D012189:Retrospective Studies; D012307:Risk Factors; D014792:Visual Acuity / Q000502:physiology*