title: Core drug-drug interaction alerts for inclusion in pediatric electronic health records with computerized prescriber order entry.
abstract: OBJECTIVE
  The study aims to develop a core set of pediatric drug-drug interaction (DDI) pairs for which electronic alerts should be presented to prescribers during the ordering process.
  
  
  METHODS
  A clinical decision support working group composed of Children's Hospital Association (CHA) members was developed. CHA Pharmacists and Chief Medical Information Officers participated.
  
  
  RESULTS
  Consensus was reached on a core set of 19 DDI pairs that should be presented to pediatric prescribers during the order process.
  
  
  CONCLUSIONS
  We have provided a core list of 19 high value drug pairs for electronic drug-drug interaction alerts to be recommended for inclusion as high value alerts in prescriber order entry software used with a pediatric patient population. We believe this list represents the most important pediatric drug interactions for practical implementation within computerized prescriber order entry systems.
authors: From the *Divisions of Emergency Medicine and Infectious Diseases, Boston Children's Hospital Boston, MA, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts; †Department of Clinical Informatics, Lucile Packard Children's Hospital; ‡Department of Pediatrics, Stanford School of Medicine, Palo Alto, California; §Hospitalist Division, Seattle Children's Hospital and Department of Pediatrics, University of Washington, Seattle, Washington; ∥Division of Pediatric Critical Care, Children's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota; ¶Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and #Department of Pharmacy, Boston Children's Hospital, Boston, Massachusetts.
authors: Marvin B
authors: MB
authors: Harper
authors: Christopher A
authors: CA
authors: Longhurst
authors: Troy L
authors: TL
authors: McGuire
authors: Rod
authors: R
authors: Tarrago
authors: Bimal R
authors: BR
authors: Desai
authors: Al
authors: A
authors: Patterson
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data*; D002648:Child; D002669:Child Welfare / Q000706:statistics & numerical data; D004347:Drug Interactions; D004360:Drug Therapy, Computer-Assisted / Q000592:standards* / Q000706:statistics & numerical data; D057286:Electronic Health Records; D005260:Female; D006801:Humans; D008297:Male; D050316:Medical Order Entry Systems / Q000592:standards* / Q000706:statistics & numerical data; D008508:Medication Errors / Q000517:prevention & control*; D010372:Pediatrics; D014481:United States