title: Photo-click living strategy for controlled, reversible exchange of biochemical ligands.
abstract: A novel addition-fragmentation-chain transfer capable allyl sulfide functionalized PEG hydrogel is reported to allow controlled, reversible exchange of biochemical ligands. The exchange of biochemical ligands is achieved without permanent consumption of reactive functionalities. Demonstrated is the ability to exchange biochemical ligands multiple times using cytocompatible 720 nm two-photon light.
authors: Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado Boulder, Boulder, CO, 80303, USA.
authors: Navakanth R
authors: NR
authors: Gandavarapu
authors: Malar A
authors: MA
authors: Azagarsamy
authors: Kristi S
authors: KS
authors: Anseth
mesh_terms: D000498:Allyl Compounds / Q000737:chemistry; D016227:Benzoquinones / Q000737:chemistry; D001671:Biochemistry / Q000379:methods*; D057930:Click Chemistry; D005898:Glass / Q000737:chemistry; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D008024:Ligands; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000737:chemistry; D019809:Streptavidin / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry
chemical_list: D000498:Allyl Compounds; D016227:Benzoquinones; D020100:Hydrogels; D008024:Ligands; D013440:Sulfides; C004532:quinone; D011092:Polyethylene Glycols; C038491:allyl sulfide; D019809:Streptavidin
keywords: addition fragmentation chain transfer; hydrogels; photo-patterning; thiol-ene reaction