title: The dopamine D3receptor antagonist YQA14 that inhibits the expression and drug-primed reactivation of morphine-induced conditioned place preference in rats.
abstract: Increasing evidence suggests that the mesolimbic dopamine system plays a critical role in opioid addiction. However, there is currently no standard drug treatment for opioid addiction. Growing preclinical evidence indicates that the dopamine D3receptor antagonists are the potential anti-addiction pharmacotherapeutic agents based on in animal models of multiple drug addiction. In this study, we investigated the inhibitory effects of YQA14, a novel dopamine D3receptor antagonist with a high affinity and selectivity for dopamine D3receptor, using morphine-induced conditioned place preference (CPP) in rats. The results suggested that YQA14 (6.25-25mg/kg; intraperitoneal, i.p.) decreased the expression of morphine (10mg/kg, s.c.)-induced CPP in a dose-related manner but did not influence the acquisition of morphine-induced CPP. At a 25mg/kg dose of YQA14, it also notably inhibited the reactivation of morphine-priming CPP. These findings suggest that YQA14 is a potential agent for anti-opioid addiction which warrants further study and development.
authors: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China; Central south university, Changsha 410013, China.
authors: Rongrong
authors: R
authors: Hu
authors: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
authors: Rui
authors: R
authors: Song
authors: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
authors: Rifang
authors: R
authors: Yang
authors: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: ruibinsu@126.com.
authors: Ruibin
authors: R
authors: Su
authors: Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China. Electronic address: jinli9802@163.com.
authors: Jin
authors: J
authors: Li
keywords: Addiction; Conditioned place preference; D(3) receptor; Opioid; YQA14