title: Prognostic significance of pathological complete response following neoadjuvant chemotherapy for operable breast cancer.
abstract: The aim of the present retrospective study was to ascertain the significance of pathological complete response (pCR) on overall survival (OS) and disease-free survival (DFS) in each disease subtype of operable breast cancer. Using a single-institution database, 90 patients were identified, who received neoadjuvant chemotherapy (NAC) for operable breast cancer and were eligible for the analysis. In total, 10 patients (11.1%) had succumbed to their diseases and 20 (22.2%) had succumbed to their diseases or exhibited recurrences. The OS of patients with triple-negative (TN) tumors was significantly lower than that of patients with other disease subtypes (P=0.016). The DFS of patients with luminal tumors was higher than that of patients with other subtypes. Survival was improved with pCR following NAC (P=0.044). Across all subtypes, patients who achieved pCR exhibited a higher DFS than patients who did not, but not significantly. pCR only improved OS and DFS in the TN disease subtype (P=0.022 and P=0.048, respectively). pCR following NAC may have prognostic value in TN breast cancer.
authors: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Hidemi
authors: H
authors: Kawajiri
authors: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Tsutomu
authors: T
authors: Takashima
authors: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Naoki
authors: N
authors: Aomatsu
authors: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Shinichiro
authors: S
authors: Kashiwagi
authors: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Satoru
authors: S
authors: Noda
authors: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Naoyoshi
authors: N
authors: Onoda
authors: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Tetsurou
authors: T
authors: Ishikawa
authors: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan.
authors: Kosei
authors: K
authors: Hirakawa
keywords: breast cancer; neoadjuvant chemotherapy; pathological complete response; triple-negative subtype