title: Getting off the ground state: X chromosome inactivation knocks down barriers to differentiation.
abstract: Female mouse embryonic stem cells (mESCs) contain two active X chromosomes, with one undergoing random inactivation upon differentiation. Schulz et al. (2014) now demonstrate that the presence of two active X chromosomes in mESCs prevents exit from pluripotency by blocking MAPK signaling, ensuring synchronization between X chromosome dosage compensation and development.
authors: Department of Reproductive Medicine, University of California, San Diego, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA 92037, USA.
authors: Robert
authors: R
authors: Morey
authors: Department of Reproductive Medicine, University of California, San Diego, Sanford Consortium for Regenerative Medicine, 2880 Torrey Pines Scenic Drive, La Jolla, CA 92037, USA. Electronic address: llaurent@ucsd.edu.
authors: Louise C
authors: LC
authors: Laurent
mesh_terms: D000818:Animals; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology*