title: EXTRACTING BIOMEDICALLY IMPORTANT INFORMATION FROM LARGE, AUTOMATED IMAGING EXPERIMENTS.
abstract: Major challenges remain in the extraction of rich information from high-throughput microscopy experiments. In this paper, I describe some of these challenges, particularly those that are the subject of ongoing research in my laboratory. The challenges include segmenting neurons, co-cultures of different cell types, and whole organisms; segmenting and tracking cells in time-lapse images; quantifying complex phenotypic changes; and discovering biologically relevant subpopulations of cells.
authors: Imaging Platform, Broad Institute of Harvard and MIT.
authors: Anne E
authors: AE
authors: Carpenter
keywords: C. elegans; co-cultures; fluorescence microscopy; high-throughput; screening