title: Chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent.
abstract: The metastatic process is complex and remains a major obstacle in the management of colorectal cancer. To gain a better insight into the pathology of metastasis, we investigated genomic aberrations in a large cohort of matched colorectal cancer primaries and distant metastases from various sites by high resolution array comparative genomic hybridization. In total, 62 primary colorectal cancers, and 68 matched metastases (22 liver, 11 lung, 12 ovary, 12 omentum, and 11 distant lymph nodes) were analyzed. Public datasets were used for validation purposes. Metastases resemble their matched primary tumors in the majority of the patients. This validates the significant overlap in chromosomal aberrations between primary tumors and corresponding metastases observed previously. We observed 15 statistically significant different regions between the primary tumors and their matched metastases, of which only one recurrent event in metastases was observed. We conclude, based on detailed analysis and large independent datasets, that chromosomal copy number aberrations in colorectal metastases resemble their primary counterparts, and differences are typically non-recurrent.
authors: Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors: Leonie J M
authors: LJ
authors: Mekenkamp
authors: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
authors: Josien C
authors: JC
authors: Haan
authors: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
authors: Daniëlle
authors: D
authors: Israeli
authors: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
authors: Hendrik F B
authors: HF
authors: van Essen
authors: Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors: Jeroen R
authors: JR
authors: Dijkstra
authors: Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors: Patricia
authors: P
authors: van Cleef
authors: Department of Medical Oncology, Academic Medical Center, Amsterdam, The Netherlands.
authors: Cornelis J A
authors: CJ
authors: Punt
authors: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
authors: Gerrit A
authors: GA
authors: Meijer
authors: Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors: Iris D
authors: ID
authors: Nagtegaal
authors: Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands.
authors: Bauke
authors: B
authors: Ylstra
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D056915:DNA Copy Number Variations; D030541:Databases, Genetic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis