title: The relationship between salivary insulin-like growth factor I and quantitative cervical maturational stages of skeletal maturity.
abstract: OBJECTIVE
  Insulin-like growth factor (IGF-I) has been used as an indicator of growth hormone levels and hence can also be used as a marker of growth. The main objective of the study was to quantify salivary IGF-I levels and its secretion rate at different quantitative cervical maturation (QCVM) stages and evaluate a possible role for salivary IGF-I in evaluating skeletal growth.
  
  
  METHODS
  Forty-five subjects (24 female, 21 male) between the ages of 7 and 23 years were included in the study. Each subject had personal information, a lateral cephalogram, and a parotid saliva sample collected on the same day.
  
  
  RESULTS
  Salivary IGF-I levels and salivary secretion rates were lowest at QCVM skeletal stages previously associated with the acceleration phase of mandibular growth. Highest levels were found at the high velocity stage. After this there was gradual drop in salivary IGF-I levels and secretion rate at deceleration and completing velocity stages. Relatively high levels in the decelerating velocity stage may be an indication of residual skeletal growth. There was a negative correlation between patient age and levels of IGF-I and its secretion rate, once growth velocity decreased.
  
  
  CONCLUSIONS
  Salivary IGF-I levels or its secretion rate can be used as an indicator of skeletal growth but longitudinal data are necessary to confirm salivary IGF-I as a marker for skeletal growth prediction and residual mandibular growth.
authors: Government Dental College, Nagpur Maharashtra, India.
authors: Subash
authors: S
authors: Nayak
authors: Government Dental College, Nagpur Maharashtra, India.
authors: Wasundhara A
authors: WA
authors: Bhad Patil
authors: Government Dental College, Nagpur Maharashtra, India.
authors: Umal Hiralal
authors: UH
authors: Doshi
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton / Q000379:methods*; D000367:Age Factors; D015415:Biomarkers / Q000032:analysis; D002508:Cephalometry / Q000379:methods; D002574:Cervical Vertebrae / Q000254:growth & development*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D008297:Male; D008334:Mandible / Q000254:growth & development; D010306:Parotid Gland / Q000378:metabolism; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I
keywords: Insulin-like growth factor I; cervical maturation; saliva