title: [Body mass index correlates with the level of serum prostate-specific antigen in men in Fangcheng area of Guangxi].
abstract: OBJECTIVE
  To investigate the influence of body mass index (BMI) on the serum prostate-specific antigen (PSA) level in males in the Fangcheng area of Guangxi.
  
  
  METHODS
  We reviewed the health examination data of males collected from September 2009 to December 2011, including their height, weight, BMI, and serum PSA level. The subjects were categorized as underweight (BMI <18.5 kg/m2), normal (BMI 18.5-22.9 kg/m2), overweight (BMI 23.0-27.4 kg/m2), and obese (BMI > or = 27.5 kg/m2), and divided into four age groups: 20-29, 30-39, 40-49, and > or = 50 years old. The PSA levels were stratified by the BMI category for statistical analysis.
  
  
  RESULTS
  A total of 2,397 men were included in this study, with a mean age of (37.4 +/- 11.0) yr, BMI of (23.3 +/- 3.4) kg/m2, and PSA level of (0.98 +/- 0.93) microg/L. There were significant differences in the age-associated PSA levels in the groups with BMI < 23 (0.81 microg/L) and > or = 23 kg/m2 (0.78 microg/L) (P < 0.05), as well as in those with BMI < 27.5 (0.81 microg/L) and > or = 27. 5 kg/m2 (0.70 microg/L) (P < 0.05). In the 30-39 and 40-49 age groups, the PSA levels were significantly decreased with the increase of BMI (P < 0.05).
  
  
  CONCLUSIONS
  Increased BMI is associated with decreased PSA in men <50 years old in the Fangcheng area of Guangxi, which should be taken into consideration while determining whether to carry out prostate biopsy as part of early prostate cancer detection in young men with marginal PSA levels.
authors: Research Institute of Urology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors: Yong-Ming
authors: YM
authors: Wu
authors: Center for Genomic and Personalized Medicine, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors: Yong
authors: Y
authors: Gao
authors: Center for Genomic and Personalized Medicine, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors: Ai-Hua
authors: AH
authors: Tan
authors: Center for Genomic and Personalized Medicine, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors: Xue
authors: X
authors: Qin
authors: Research Institute of Urology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.
authors: Zeng-Nan
authors: ZN
authors: Mo
mesh_terms: D000328:Adult; D015992:Body Mass Index; D001835:Body Weight; D002681:China; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood*; D055815:Young Adult
chemical_list: D017430:Prostate-Specific Antigen