title: Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth.
abstract: Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7β,6β-dihydroxyroyleanone (2), 7β-acetoxy-6β-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and α-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on α-glucosidase with IC50 values from 33 to 275 μM. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis.
authors: Department of Natural Drugs and.
authors: Renata
authors: R
authors: Kubínová
authors: Radka
authors: R
authors: Pořízková
authors: Alice
authors: A
authors: Navrátilová
authors: Oldřich
authors: O
authors: Farsa
authors: Zuzana
authors: Z
authors: Hanáková
authors: Adriana
authors: A
authors: Bačinská
authors: Alois
authors: A
authors: Cížek
authors: Marie
authors: M
authors: Valentová
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D013293:Enterococcus faecalis / Q000187:drug effects*; D065089:Glycoside Hydrolase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006736:Horses; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D031346:Plectranthus / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D002800:Cholinesterase Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts; D002802:Cholinesterases; D000520:alpha-Glucosidases
keywords: antibacterial activity; cholinesterase; diterpenoids; rosmarinic acid; α-glucosidase