title: Association of adiponectin (ADIPOQ) rs2241766 polymorphism and dyslipidemia in HIV/HCV-coinfected patients.
abstract: BACKGROUND
  The adiponectin (ADIPOQ) rs2241766 polymorphism is related to metabolic abnormalities. The aim of this study was to evaluate the association of the ADIPOQ rs2241766 polymorphism with serum dyslipidemia and insulin resistance (IR) in human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients.
  
  
  METHODS
  We carried out a cross-sectional study on 262 patients. ADIPOQ rs2241766 polymorphisms were genotyped by GoldenGate® assay. Generalized linear models (GLMs) were used to compare continuous outcome variables (total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), non-HDL-C and homeostatic model assessment (HOMA)) and categorical outcome variables (TC≥200 mg/dL, TG≥170 mg/dL, LDL-C≥100 mg/dL, HDL-C≤35 mg/dL, non-HDL-C≥120 mg/dL and HOMA≥3·8) according to ADIPOQ genotype under a dominant inheritance model.
  
  
  RESULTS
  Patients with the rs2241766 GG/GT genotype had significantly lower serum TC levels (P=0·038) and percentages of TC≥200 mg/dL (P=0·022) than rs2241766 TT carriers. When adjusted GLM was performed, rs2241766 GG/GT was associated with low serum TC levels (arithmetic mean ratio (AMR)=0·92 [(95% CI=0·85; 0·99) P=0·024]) and low likelihood of TC≥200 mg/dL (odds ratio (OR)=0·32 [(95% CI=0·11; 0·88) P=0·027]. When stratifying by steatosis, no significant values were found for patients without steatosis. However, for patients with steatosis, rs2241766 GG/GT genotypes were related to low TC serum values of TC (AMR=0·89; P=0·027), LDL-C (AMR=0·85; P=0·039) and non-HDL-C (AMR=0·86; P=0·015). No significant associations were found between rs2241766 and HOMA values.
  
  
  CONCLUSIONS
  The presence of the ADIPOQ rs2241766 G allele (GG/GT genotype) was associated with a protective effect against dyslipidemia, primarily in HIV/HCV-coinfected patients with steatosis.
authors: Viral Infection and Immunity Unit, National Centre of Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
authors: Daniel
authors: D
authors: Pineda-Tenor
authors: Juan
authors: J
authors: Berenguer
authors: Pilar
authors: P
authors: García-Broncano
authors: María A
authors: MA
authors: Jiménez-Sousa
authors: Amanda
authors: A
authors: Fernández-Rodríguez
authors: Cristina
authors: C
authors: Diez
authors: Mónica
authors: M
authors: García-Álvarez
authors: Ana
authors: A
authors: Carrero
authors: Pilar
authors: P
authors: Catalán
authors: Teresa
authors: T
authors: Aldámiz-Echevarria
authors: Salvador
authors: S
authors: Resino
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D008076:Cholesterol, HDL / Q000378:metabolism; D008078:Cholesterol, LDL / Q000378:metabolism; D060085:Coinfection; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000150:complications; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D014280:Triglycerides / Q000378:metabolism
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides
keywords: AIDS; Adiponectin; SNPs; chronic hepatitis C; dyslipidemia; metabolic disturbance