title: Limbic substrates of the effects of neuropeptide Y on intake of and motivation for palatable food.
abstract: OBJECTIVE
  Neuropeptide Y (NPY), given centrally augments food intake and the motivation to work for palatable food. Here, the brain regions were identified through which NPY increases food intake and motivation.
  
  
  METHODS
  NPY was infused into three brain regions implicated in food intake and motivation: the lateral hypothalamus (LH), nucleus accumbens shell (NAc), and ventral tegmental area (VTA). Motivation for sucrose was assessed using a progressive-ratio schedule of reinforcement in which the effort to obtain successive rewards increased incrementally. To disentangle the effects of NPY on motivation for palatable food from food consumption, free-feeding experiments were performed in which animals had ad libitum access to sucrose pellets.
  
  
  RESULTS
  Infusion of NPY into either VTA or NAc increased the motivation to respond for sucrose, whereas infusion of NPY in either NAc or LH increased sucrose consumption. In addition, the effect of intra-VTA NPY on motivation for food was attenuated after pretreatment with the dopamine receptor antagonist alpha-flupenthixol.
  
  
  CONCLUSIONS
  Specific limbic substrates through which NPY influences consumption of and motivation for palatable food were identified by these data. The motivational effects of NPY are exerted through the VTA, its consummatory effects through the LH, and the NAc is involved in both.
authors: Department of Translational Neuroscience Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
authors: Rahul
authors: R
authors: Pandit
authors: Mieneke C M
authors: MC
authors: Luijendijk
authors: Louk J M J
authors: LJ
authors: Vanderschuren
authors: Susanne E
authors: SE
authors: la Fleur
authors: Roger A H
authors: RA
authors: Adan
mesh_terms: D000818:Animals; D005247:Feeding Behavior / Q000187:drug effects*; D007026:Hypothalamic Area, Lateral / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009042:Motivation / Q000187:drug effects*; D009478:Neuropeptide Y / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013395:Sucrose / Q000008:administration & dosage; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000378:metabolism
chemical_list: D009478:Neuropeptide Y; D013395:Sucrose