title: Effect of double-bond substituents on the rate of cyclization of α-carbomethoxyhex-5-enyl radicals.
abstract: Rate constants have been calculated, and compared with experimental results, for the cyclizations of 1-carbomethoxy-1-methyl-5-hexenyl radicals (2) with various substituents on C6. The calculations have been done by DFT at the B3LYP/6-311++G** level of theory. They show considerable interaction between C5 and the radical centers even in the ground state of all of the radicals 2. Experimentally, the radicals have been generated by H(•) transfer to the corresponding acrylate esters 1 and the yields of cyclized products compared to the calculated rate constants. (The "cyclized products" include those from cyclohydrogenation, 4, and those from cycloisomerization, 9.) Two phenyl substituents on C6 (2i), or a phenyl and a methyl substituent (2g, 2h), increase the rate of cyclization, but a single phenyl substituent on C6 produces a greater increase. The calculations show that the two phenyl substituents are twisted in the transition state for cyclization, while a single phenyl substituent remains flat in that transition state. A methyl substituent on C6 along with a single phenyl causes the phenyl to twist in the transition state and decreases the rate constant for cyclization below that of the H/Ph-substituted 2e, 2f.
authors: Department of Chemistry, Columbia University , 3000 Broadway, New York, New York 10027, United States.
authors: Arthur
authors: A
authors: Han
authors: Tudor
authors: T
authors: Spataru
authors: John
authors: J
authors: Hartung
authors: Gang
authors: G
authors: Li
authors: Jack R
authors: JR
authors: Norton