title: HE4 as a serum biomarker for ROMA prediction and prognosis of epithelial ovarian cancer.
abstract: OBJECTIVE
  Human epididymis protein 4 (HE4) has been suggested to be a novel biomarker of epithelial ovarian cancer (EOC). The present study aimed to evaluate and compare HE4 with the commonly used marker, carbohydrate antigen 125 (CA125), in prediction and therapy-monitoring of EOC.
  
  
  METHODS
  Serum HE4 concentrations from 123 ovarian cancer patients and 174 controls were measured by Roche electrochemiluminescent immunoassay (ECLIA). Risk of ovarian malignancy algorithm (ROMA) values were calculated and assessed. In addition, the prospects of HE4 detection for therapy-monitoring were evaluated in EOC patients.
  
  
  RESULTS
  The ROMA score could classify patients into high- and low-risk groups with malignancy. Indeed, lower serum HE4 was significantly associated with successful surgical therapy. Specifically, 38 patients with EOC exhibited a greater decline of HE4 compared with CA125. In contrast, elevation of HE4 better predicted recurrence (of 46, 11 patients developed recurrence, and with it increased HE4 serum concentrations) and a poor prognosis than CA125.
  
  
  CONCLUSIONS
  This study suggests that serum HE4 levels are closely associated with outcome of surgical therapy and disease prognosis in Chinese EOC patients.
authors: Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China E-mail : lurenquan66@hotmail.com.
authors: Wen-Ting
authors: WT
authors: Chen
authors: Xiang
authors: X
authors: Gao
authors: Xiao-Dian
authors: XD
authors: Han
authors: Hui
authors: H
authors: Zheng
authors: Lin
authors: L
authors: Guo
authors: Ren-Quan
authors: RQ
authors: Lu
mesh_terms: D000465:Algorithms; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D000077216:Carcinoma, Ovarian Epithelial; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000097:blood*; D009375:Neoplasms, Glandular and Epithelial / Q000097:blood* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000097:blood* / Q000601:surgery; D011379:Prognosis; D011506:Proteins / Q000378:metabolism*; D012189:Retrospective Studies; D018570:Risk Assessment; D000081102:WAP Four-Disulfide Core Domain Protein 2
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D011506:Proteins; D000081102:WAP Four-Disulfide Core Domain Protein 2; C569698:WFDC2 protein, human