title: Synthesis of the C1-C18 fragment of rhizopodin: late-state introduction of the oxazole.
abstract: The synthesis of the C1-C18 fragment of the myxobacteria metabolite rhizopodin is described. Initial attempts at installing the E,E-diene via cross coupling with an oxazole fragment gave poor results. An alternative approach, in which the diene was formed prior and the oxazole introduced by an acylation/O,N-shift protocol, gave the C1-C18 fragment 2 of rhizopodin (1).
authors: School of Chemistry, The Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne , Victoria 3010, Australia.
authors: Tobias
authors: T
authors: Bender
authors: Darran
authors: D
authors: Loits
authors: Jonathan M
authors: JM
authors: White
authors: Mark A
authors: MA
authors: Rizzacasa
mesh_terms: D018942:Macrolides / Q000138:chemical synthesis; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D018942:Macrolides; D010080:Oxazoles; C081739:rhizopodin