title: A case of hyperpigmentation and acanthosis nigricans by testosterone injections.
abstract: Drug-related skin disorders may occur in many different ways. Despite pigmentary changes being less important for morbidity, these changes precipitate depressed mood and reduce self-confidence. Testosterone is a steroid hormone from the androgen group and primarily used for the treatment of hypogonadism in males. Testosterone replacement can cause skin problems like acne, hair loss, redness, pain, or infection at the injection site. The study was conducted on a 49-year-old man with adult onset idiopathic hypogonadotropic hypogonadism, which is an acquired form of isolated gonadotropin-releasing hormone deficiency. He was presented with lack of energy and decreased sexual function 10 years ago and was given an oil-based injectable blend of four esterized testosterone compounds as hormone replacement treatment in a urology polyclinic. He was referred to our polyclinic by endocrinologist because of progressive hyperpigmentation marked on his face and oral mucosa. In the present study, we report the first testosterone therapy-related facial and oral mucosal hyperpigmentation and acanthosis nigricans in the same patient.
authors: Department of Dermatology, School of Medicine, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
authors: As
authors: A
authors: Karadag
authors: Department of Dermatology, School of Medicine, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
authors: M
authors: M
authors: Kavala
authors: Department of Dermatology, School of Medicine, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey filizsvet@yahoo.com.
authors: Ft
authors: F
authors: Demir
authors: Department of Dermatology, School of Medicine, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
authors: Z
authors: Z
authors: Turkoğlu
authors: Department of Endocrinology, School of Medicine, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
authors: I
authors: I
authors: Kartal
authors: Department of Pathology, School of Medicine, Goztepe Research and Training Hospital, Istanbul Medeniyet University, Istanbul, Turkey.
authors: E
authors: E
authors: Zemheri
mesh_terms: D000052:Acanthosis Nigricans / Q000139:chemically induced* / Q000473:pathology; D005145:Face; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced* / Q000473:pathology; D007006:Hypogonadism / Q000188:drug therapy; D007267:Injections; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D012867:Skin / Q000473:pathology; D013739:Testosterone / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D013739:Testosterone
keywords: Drug-induced hyperpigmentation; acanthosis nigricans; testosterone