title: Self-assembly of different single-chain bolaphospholipids and their miscibility with phospholipids or classical amphiphiles.
abstract: A variety of bolalipids with a single long alkyl chain and two identical headgroups self-assemble in aqueous solutions into helical entangled nanofibers leading to the formation of a hydrogel. An increase in temperature usually leads to the break-up of the fiber structure into micellar aggregates. In this paper the question is addressed whether bolalipids of different lengths or different headgroup structures can form mixed fibers. Also, the stability of the fiber aggregation of bolalipids in mixtures with phospholipids forming lamellar bilayers is discussed. Here, the question whether single-chain bolalipids can be incorporated into phospholipid bilayers to stabilize bilayer membranes is important, as possibly lipid vesicles used for drug delivery can be improved. Finally, the stability of the fiber aggregate against solubilisation by common surfactants was studied. The paper addresses the question which type of aggregate structure dominates the self-assembly of bipolar and monopolar amphiphiles in aqueous suspension.
authors: Institute of Chemistry - Physical Chemistry, Martin-Luther-University Halle-Wittenberg, von-Danckelmann-Platz 4, D-06120 Halle, Germany.
authors: Alfred
authors: A
authors: Blume
authors: Institute of Pharmacy - Pharmaceutical Chemistry, Martin-Luther-University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120 Halle, Germany.
authors: Simon
authors: S
authors: Drescher
authors: Institute of Chemistry - Physical Chemistry, Martin-Luther-University Halle-Wittenberg, von-Danckelmann-Platz 4, D-06120 Halle, Germany; Novaliq GmbH Heidelberg, Im Neuenheimer Feld 515, D-69120 Heidelberg, Germany.
authors: Gesche
authors: G
authors: Graf
authors: Institute of Chemistry - Physical Chemistry, Martin-Luther-University Halle-Wittenberg, von-Danckelmann-Platz 4, D-06120 Halle, Germany.
authors: Karen
authors: K
authors: Köhler
authors: Center for structure and dynamics of proteins (MZP), Martin-Luther-University Halle-Wittenberg, Biocenter, Weinbergweg 22, D-06120 Halle, Germany.
authors: Annette
authors: A
authors: Meister
mesh_terms: D055598:Chemical Phenomena; D005663:Furans / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008051:Lipid Bilayers / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D057139:Nanofibers / Q000737:chemistry; D010743:Phospholipids / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D005663:Furans; D008051:Lipid Bilayers; D010743:Phospholipids; D011728:Pyridones; D013501:Surface-Active Agents; C543575:bolaamphiphile
keywords: Aggregation behavior; Bilayers; Bolalipids; Micelles; Miscibility; Nanofibers; Phospholipids; Self-assembly; Surfactants