title: miR-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2.
abstract: miR-625 has been reported to exhibit abnormal expression in esophageal cancer (EC), but the mechanism and functions of miR-625 in esophageal cancer remain unclear. miR-625 down-regulation and Sox2 up-regulation were validated by qRT-PCR in 158 EC samples. Low expression of miR-625 promotes cell proliferation and invasion, while high expression of miR-625 has the opposite effect. Sox2, a target gene of miR-625, was examined by luciferase assay and western blot. Our data suggest that miR-625 may regulate the biological processes of EC via controlling Sox2 expression.
authors: Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi 214062, People's Republic of China.
authors: Zhiqiang
authors: Z
authors: Wang
authors: Department of Gastroenterology, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi 214062, People's Republic of China.
authors: Qiao
authors: Q
authors: Qiao
authors: Department of Clinical Laboratory, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi 214062, People's Republic of China.
authors: Min
authors: M
authors: Chen
authors: Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi 214062, People's Republic of China.
authors: Xianhua
authors: X
authors: Li
authors: Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi 214062, People's Republic of China.
authors: Zhenjun
authors: Z
authors: Wang
authors: Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi 214062, People's Republic of China.
authors: Chuanxin
authors: C
authors: Liu
authors: Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Forth People's Hospital of Wuxi City, Wuxi 214062, People's Republic of China. Electronic address: wxsyxzt@163.com.
authors: Zongtao
authors: Z
authors: Xie
mesh_terms: D020413:3' Untranslated Regions; D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D000368:Aged; D017209:Apoptosis; D001483:Base Sequence; D001665:Binding Sites; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000556:secondary; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D015536:Down-Regulation; D004938:Esophageal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D034622:RNA Interference; D055748:SOXB1 Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; C575476:MIRN625 microRNA, human; D035683:MicroRNAs; C527782:SOX2 protein, human; D055748:SOXB1 Transcription Factors
keywords: Esophageal cancer; Invasion; Proliferation; Sox2; miR-625