title: Modulation of persistent organic pollutant toxicity through nutritional intervention: emerging opportunities in biomedicine and environmental remediation.
abstract: Environmental pollution is increasing worldwide, and there is evidence that exposure to halogenated persistent organic pollutants (POPs) such as polychlorinated biphenyls can contribute to the pathology of inflammatory diseases such as atherosclerosis, diabetes, and cancer. Pollutant removal from contaminated sites and subsequent pollutant degradation are critical for reducing the long-term health risks associated with exposure. However, complete remediation of a toxicant from the environment is very difficult and cost-prohibitive. Furthermore, remediation technologies often result in the generation of secondary toxicants. Considering these circumstances, environmentally-friendly and sustainable remediation technologies and biomedical solutions to reduce vulnerability to environmental chemical insults need to be explored to reduce the overall health risks associated with exposure to environmental pollutants. We propose that positive lifestyle changes such as healthful nutrition and consumption of diets rich in fruits and vegetables or bioactive nutrients with antioxidant and/or anti-inflammatory properties will reduce the body's vulnerability to environmental stressors and thus reduce toxicant-mediated disease pathologies. Interestingly, emerging evidence now implicates the incorporation of bioactive nutrients, such as plant-derived polyphenols, in technologies focused on the capture, sensing and remediation of halogenated POPs. We propose that human nutritional intervention in concert with the use of natural polyphenol sensing and remediation platforms may provide a sensible means to develop primary and long-term prevention strategies of diseases associated with many environmental toxic insults including halogenated POPs.
authors: Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
authors: Michael C
authors: MC
authors: Petriello
authors: Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Chemistry, College of Arts and Sciences, University of Kentucky, Lexington, KY 40506, USA.
authors: Bradley J
authors: BJ
authors: Newsome
authors: Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, KY 40506, USA.
authors: Thomas D
authors: TD
authors: Dziubla
authors: Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, KY 40506, USA.
authors: J Zach
authors: JZ
authors: Hilt
authors: Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Department of Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, KY 40506, USA.
authors: Dibakar
authors: D
authors: Bhattacharyya
authors: Superfund Research Center, University of Kentucky, Lexington, KY 40536, USA; Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA; Department of Animal and Food Sciences, College of Agriculture Food and Environment, University of Kentucky, Lexington, KY 40546, USA.
authors: Bernhard
authors: B
authors: Hennig
mesh_terms: D000975:Antioxidants; D004785:Environmental Pollutants / Q000633:toxicity*; D004787:Environmental Pollution / Q000706:statistics & numerical data*; D052918:Environmental Restoration and Remediation / Q000379:methods*; D005502:Food; D006801:Humans; D009753:Nutritive Value
chemical_list: D000975:Antioxidants; D004785:Environmental Pollutants
keywords: Antioxidant response; Nutrition; Oxidative stress; POP toxicity; Polyphenol; Sustainable remediation