title: Organelle-selective fluorescent Cu2+ ion probes: revealing the endoplasmic reticulum as a reservoir for Cu-overloading.
abstract: Two novel Cu(2+) sensors, 1 and 2, bearing naphthalimide and a DPA moiety were synthesized to study copper accumulation in organelles by selective Cu(2+) sensing. The ER-selective Cu(2+) sensor 1 that we developed serves as a valuable tool for understanding the subcellular compartmentalization and roles of copper ions in physiology and pathophysiology.
authors: Department of Chemistry, Korea University, Seoul 136-701, Korea. jongskim@korea.ac.kr.
authors: Yun Hak
authors: YH
authors: Lee
authors: Nayoung
authors: N
authors: Park
authors: Young Bin
authors: YB
authors: Park
authors: Yu Jeong
authors: YJ
authors: Hwang
authors: Chulhun
authors: C
authors: Kang
authors: Jong Seung
authors: JS
authors: Kim
mesh_terms: D003300:Copper / Q000032:analysis* / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000737:chemistry* / Q000378:metabolism; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D007477:Ions / Q000032:analysis / Q000378:metabolism; D015394:Molecular Structure; D015388:Organelles / Q000737:chemistry* / Q000378:metabolism; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D009942:Organometallic Compounds; D003300:Copper