title: Radiation redux: reserve intestinal stem cells miss the call to duty.
abstract: Distinct stem cell populations in intestinal crypts mediate tissue homeostasis and responses to epithelial damage such as radiation. Now in Cell Stem Cell, Metcalfe et al. (2014) demonstrate that homeostatic, proliferative Lrg5(+) cells are necessary to regenerate the epithelium after radiation, whereas quiescent Lgr5(-) reserve stem cells are surprisingly radiosensitive.
authors: Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address: ramesh_shivdasani@dfci.harvard.edu.
authors: Ramesh A
authors: RA
authors: Shivdasani
mesh_terms: D000818:Animals; D007422:Intestines / Q000502:physiology* / Q000528:radiation effects*; D011839:Radiation, Ionizing; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology*
chemical_list: C493597:Lgr5 protein, mouse; D043562:Receptors, G-Protein-Coupled