title: [Surgical treatment of penile Paget's disease: a report of 10 cases].
abstract: OBJECTIVE
  To investigate the clinical characteristics and surgical treatment of penile Paget's disease.
  
  
  METHODS
  We retrospectively analyzed the treatment and follow-up data of 10 cases of penile Paget's disease surgically treated in Jiangsu Provincial Government Hospital and Jiangsu Provincial People's Hospital from 2008 to 2012.
  
  
  RESULTS
  All the 10 patients received expanded local resection of the lesion with reconstruction of the defects with scrotal skin flaps or free skin flaps from the thigh. All surgeries were successful and the postoperative course was uneventful with complete graft survival and no lymph node metastasis. IIEF scores obtained before and 1 -2 months after surgery showed no statistically significant differences in the penile erectile function (P = 0.229), sexual orgasm (P = 0.761), and sexual satisfaction (P = 0.801) of the patients.
  
  
  CONCLUSIONS
  When penile skin lesions suggest the possibility of Paget's disease, biopsy should be performed and surgery should follow as soon as possible. The ideal surgical option is expanded local resection of the lesion with reconstruction of the defects with scrotal skin flaps or free flaps according to the patient's specific conditions.
authors: Department of Dermatology, Jiangsu Provincial Government Hospital, Nanjing, Jiangsu 210024, China.
authors: Xiao-Yun
authors: XY
authors: Xu
authors: Department of Urology, Jiangsu Provincial Government Hospital, Nanjing, Jiangsu 210024, China.
authors: Ning
authors: N
authors: Shao
authors: Department of Urology, Jiangsu Provincial Government Hospital, Nanjing, Jiangsu 210024, China.
authors: Di
authors: D
authors: Qiao
authors: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Quan
authors: Q
authors: Li
authors: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Chang-Jun
authors: CJ
authors: Yin
authors: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Li-Xin
authors: LX
authors: Hua
authors: Department of Urology, Jiangsu Provincial Government Hospital, Nanjing, Jiangsu 210024, China.
authors: Yi
authors: Y
authors: Ding
authors: Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors: Ning-Hong
authors: NH
authors: Song
mesh_terms: D000328:Adult; D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000601:surgery*; D010412:Penile Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome