title: Sustained release of naproxen in a new kind delivery system of carbon nanotubes hydrogel.
abstract: In this paper, carbon nanotubes (CNTs) were added into chitosan (CS) hydrogels in the form of chitosan modified CNTs (CS-CNTs) composites to prepare carbon nanotubes hydrogels (CNTs-GEL). The products, named CS-MWCNTs, were characterized by scanning electron microscope (SEM) and Fourier transform infrared (FTIR) spectroscopy. Swelling properties and effect of pH on controlled release performance of the two kinds of hydrogels, CNTs- GEL and pure chitosan hydrogels without CNTs (GEL), were investigated respectively. The results showed that CNTs-GEL possess better controlled release performance than GEL. The releasing equilibrium time of CNTs-GEL was longer than that of GEL in both pH = w7.4 and pH=1.2 conditions, although the release ratios of the model drug are similar in the same pH buffer solutions. It is found that release kinetics is better fitted Ritger-Peppas empirical model indicating a fick-diffusion process in pH = 1.2, while in pH = 7.4 it was non-fick diffusion involving surface diffusion and corrosion diffusion processes.
authors: Department of Bioengineering and Environmental Science, Changsha University, Changsha 410003, China.
authors: Xiahui
authors: X
authors: Peng
authors: School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
authors: Qiang
authors: Q
authors: Zhuang
authors: School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
authors: Dongming
authors: D
authors: Peng
authors: School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
authors: Qiuli
authors: Q
authors: Dong
authors: School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
authors: Lini
authors: L
authors: Tan
authors: School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
authors: Feipeng
authors: F
authors: Jiao
authors: Department of Bioengineering and Environmental Science, Changsha University, Changsha 410003, China.
authors: Linqi
authors: L
authors: Liu
authors: Department of Bioengineering and Environmental Science, Changsha University, Changsha 410003, China.
authors: Jingyu
authors: J
authors: Liu
authors: Department of Bioengineering and Environmental Science, Changsha University, Changsha 410003, China.
authors: Chenxi
authors: C
authors: Zhao
authors: Department of Bioengineering and Environmental Science, Changsha University, Changsha 410003, China.
authors: Xiaomei
authors: X
authors: Wang
keywords: Chitosan; Drug delivery; Hydrogel; Multi-walled carbon nanotubes; Release kinetics