title: In situ growth of porous platinum nanoparticles on graphene oxide for colorimetric detection of cancer cells.
abstract: A green approach is proposed for in situ growth of porous platinum nanoparticles on graphene oxide (PtNPs/GO). The resulting nanocomposite has been proven to function as peroxidase mimetics that can catalyze the reaction of peroxidase substrate in the presence of hydrogen peroxide. On the basis of the peroxidase-like activity, we used the PtNPs/GO as a signal transducer to develop a colorimetric assay for the direct detection of cancer cells. By using folic acid as a recognition element, a total of 125 cancer cells (MCF-7) can be distinguished by naked-eye observation. We envision that this nanomaterial could be used as a power tool for a wide range of potential applications in biotechnology and medicine.
authors: Department of Pharmaceutical Analysis, Fujian Medical University , Fuzhou 350004, China.
authors: Ling-Na
authors: LN
authors: Zhang
authors: Hao-Hua
authors: HH
authors: Deng
authors: Feng-Lin
authors: FL
authors: Lin
authors: Xiong-Wei
authors: XW
authors: Xu
authors: Shao-Huang
authors: SH
authors: Weng
authors: Ai-Lin
authors: AL
authors: Liu
authors: Xin-Hua
authors: XH
authors: Lin
authors: Xing-Hua
authors: XH
authors: Xia
authors: Wei
authors: W
authors: Chen
mesh_terms: D003124:Colorimetry; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles; D018625:Microscopy, Atomic Force; D010087:Oxides / Q000737:chemistry; D010984:Platinum / Q000737:chemistry*
chemical_list: D010087:Oxides; D010984:Platinum; D006108:Graphite