title: Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population.
abstract: As a multifunctional cytokine, interleukin-6 (IL-6) plays a key role in chronic inflammation as well as tumor growth and progression of hepatitis B virus (HBV) infection. Recent studies have implicated that single nucleotide polymorphism (SNP) -572C>G (rs1800796) located within the promoter region of IL-6 gene was associated with susceptibility to several diseases. Here, a case-control study was undertaken to investigate the association between this polymorphism and HBV-related hepatocellular carcinoma (HCC) susceptibility in a Chinese Han population. A total of 900 patients with chronic HBV infection, including 505 HBV-related HCC patients and 395 HBV infected patients without HCC were enrolled, and rs1800796 polymorphism was genotyped by the TaqMan method and DNA sequencing technology. The results indicated no significant association between rs1800796 polymorphism and the risk of HBV-related HCC in all subjects; however, a significant difference was identified in male subjects. Under the dominant model, male subjects with the G allele (CG/GG) have higher susceptibility to HBV-related HCC than those with CC genotype after adjusting confounding factors (P=0.012, odds ratio [OR] 1.68, 95% confidence interval [95% CI] 1.15-2.42). Our results suggested that rs1800796 polymorphism of IL-6 gene was associated with susceptibility to HBV-related HCC in a male Chinese Han population.
authors: Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors: Shengli
authors: S
authors: Tang
authors: Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors: Yufeng
authors: Y
authors: Yuan
authors: Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors: Yueming
authors: Y
authors: He
authors: Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors: Dingyu
authors: D
authors: Pan
authors: Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors: Yongxi
authors: Y
authors: Zhang
authors: State Key Laboratory of Virology, Institute of Virology, Medical School of Wuhan University, Wuhan 430071, China.
authors: Yuanyuan
authors: Y
authors: Liu
authors: Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors: Quanyan
authors: Q
authors: Liu
authors: Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors: Zhonglin
authors: Z
authors: Zhang
authors: Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address: zsliuwhu@126.com.
authors: Zhisu
authors: Z
authors: Liu
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000209:etiology*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000235:genetics*; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008113:Liver Neoplasms / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors; D047368:Tumor Burden
chemical_list: D015850:Interleukin-6