title: Hilar mossy cells provide the first glutamatergic synapses to adult-born dentate granule cells.
abstract: Adult-generated granule cells (GCs) in the dentate gyrus must establish synapses with preexisting neurons to participate in network activity. To determine the source of early glutamatergic synapses on newborn GCs in adult mice, we examined synaptic currents at the developmental stage when NMDA receptor-mediated silent synapses are first established. We show that hilar mossy cells provide initial glutamatergic synapses as well as disynaptic GABAergic input to adult-generated dentate GCs.
authors: McKnight Brain Institute and Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294 and Department of Biomedical & Pharmaceutical Sciences, University of Montana, Missoula, Montana 59812.
authors: Jessica H
authors: JH
authors: Chancey
authors: David J
authors: DJ
authors: Poulsen
authors: Jacques I
authors: JI
authors: Wadiche
authors: Linda
authors: L
authors: Overstreet-Wadiche
mesh_terms: D000367:Age Factors; D000818:Animals; D018891:Dentate Gyrus / Q000166:cytology / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D005260:Female; D018698:Glutamic Acid / Q000502:physiology*; D057809:HEK293 Cells; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D019599:Mossy Fibers, Hippocampal / Q000502:physiology*; D009924:Organ Culture Techniques; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018698:Glutamic Acid
keywords: GABA; adult neurogenesis; circuit; dentate gyrus; glutamate; synaptic