title: Obesity indices and inflammatory markers in obese non-diabetic normo- and hypertensive patients: a comparative pilot study.
abstract: BACKGROUND
  The aim of this study was to estimate associations between inflammatory markers and obesity indices in normo- and hypertensive subjects.
  
  
  METHODS
  65 obese adult subjects were divided into two groups: (A) of hypertensives (n = 54) and (B) of normotensives (n = 11). Waist circumference (WC), body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), visceral adiposity index (VAI), body adiposity index (BAI) and tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and high sensitivity C-reactive protein (hsCRP) serum concentrations were estimated.
  
  
  RESULTS
  In group A WHtR was higher (0.69 ± 0.07 vs 0.63 ± 0.06; p < 0.01), hsCRP correlated with BMI and WHtR (r = 0.343; p = 0.011 and r = 0.363; p < 0.01, respectively). BAI correlated with hsCRP in group A and B (r = 0.329; p < 0.05 and r = 0.642; p < 0.05; respectively) and in females and males (r = 0.305; p = 0.05 and r = 0.44; p < 0.05, respectively). In females hsCRP was higher (3.2 ± 2.2 mg/l vs 2.1 ± 1.5 mg/l; p < 0.05). In patients without lipid lowering treatment hsCRP and IL-6 were higher (3.2 ± 1.7 mg/l vs 2.4 ±2.2 mg/l; p = 0.01 and 15.9 ± 7.2 pg/ml vs 13.6 ± 9.9 pg/ml; p < 0.01, respectively).
  
  
  CONCLUSIONS
  WHtR is a sensitive index associated with chronic inflammation in obese hypertensive subjects. BAI correlates with hsCRP independently of hypertension and sex. hsCRP is more sensitive marker associated with obesity than IL-6 and TNF-α. Lipid lowering treatment influence chronic inflammation.
authors: Department of Nephrology, Hypertension and Family Medicine, Medical University of Lodz, Żeromskiego str, 113, 90-549 Lodz, Poland. stepm@op.pl.
authors: Mariusz
authors: M
authors: Stępień
authors: Anna
authors: A
authors: Stępień
authors: Rafał N
authors: RN
authors: Wlazeł
authors: Marek
authors: M
authors: Paradowski
authors: Maciej
authors: M
authors: Banach
authors: Jacek
authors: J
authors: Rysz
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D010865:Pilot Projects; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein