title: Aggressive parenteral nutrition and growth velocity in preterm infants.
abstract: BACKGROUND
  Parenteral administration of nutrients to sustain newborns' growth represents an important therapeutic challenge.
  
  
  OBJECTIVE
  To describe parenteral nutrition (PN) practices in a tertiary hospital and evaluate postnatal growth in preterm infants.
  
  
  METHODS
  Observational retrospective study over 3 months. Data on infants born or admitted to the Neonatal Department and starting PN were collected. Demographics, anthropometric data, daily caloric, protein intake data and PN components used were collected. Growth velocity was characterized by the average daily weight gain and compared to intrauterine growth.
  
  
  RESULTS
  68 preterm infants started PN during the study period. Most infants (65%) were born by caesarean and mean gestational age was 33 weeks. Twenty five percent of newborns did not regain birth weight. The remaining 75% regained birth weight on the 3rd day of PN and average daily weight gain was 16 g/kg/d, ranging between 12 and 22 g/kg/d. Although weight gain approximated intrauterine rate, most infants born <30 weeks gestation did not achieve median birth weight of the reference population. Early aggressive PN was administered with an average of 3, 11 and 3 g/Kg/d of proteins, carbohydrates and lipids respectively, reaching a maximum on the 4th day of 4, 18, 4 g/kg/d, respectively.
  
  
  CONCLUSIONS
  Aggressive PN is used in the hospital setting. The preterm infants reached birth weight earlier and had a greater velocity of growth than in other clinical trials and similar to intrauterine.
authors: Servicio de Farmacia. Hospital General Universitario Gregorio Marañón. Madrid. España.. rosa.romero@salud.madrid.org.
authors: Almudena
authors: A
authors: Ribed Sánchez
authors: Servicio de Farmacia. Hospital General Universitario Gregorio Marañón. Madrid. España.. rosa.romero@salud.madrid.org.
authors: Rosa Ma
authors: RM
authors: Romero Jiménez
authors: Servicio de Neonatología. Hospital General Universitario Gregorio Marañón. Madrid. España..
authors: Ma Carmen
authors: MC
authors: Sánchez Gómez de Orgaz
authors: Servicio de Neonatología. Hospital General Universitario Gregorio Marañón. Madrid. España..
authors: Manuel
authors: M
authors: Sánchez Luna
authors: Servicio de Farmacia. Hospital General Universitario Gregorio Marañón. Madrid. España..
authors: María
authors: M
authors: Sanjurjo Sáez
mesh_terms: D000886:Anthropometry; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006128:Growth / Q000502:physiology*; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D019102:Infant, Very Low Birth Weight; D008297:Male; D010288:Parenteral Nutrition; D012189:Retrospective Studies