title: A case of Degos disease: demonstration of C5b-9-mediated vascular injury.
abstract: A 68-year-old Japanese male presented with atrophic erythematous white lesions with peripheral dark reddish rims on his back. Multiple ulcers were detected from his stomach to his large intestine using endoscopy. Although the patient was given high doses of a steroid, aspirin, dipyridamole, and intravenous immunoglobulin therapy, he died of gastrointestinal hemorrhage, perforation and septic shock. An autopsy examination revealed pauci-inflammatory thrombotic microangiopathy with endothelial cell injury, fibrous occlusive arteriopathy, and vascular C5b-9 deposition in the wall of the gastrointestinal tract from the esophagus to the large intestine as well as in the dermis of the skin.
authors: Division of Rheumatology, Department of Medicine, Showa University School of Medicine , Tokyo , Japan.
authors: Masayu
authors: M
authors: Umemura
authors: Yusuke
authors: Y
authors: Miwa
authors: Ryo
authors: R
authors: Yanai
authors: Sakiko
authors: S
authors: Isojima
authors: Takahiro
authors: T
authors: Tokunaga
authors: Hiroyuki
authors: H
authors: Tsukamoto
authors: Ryo
authors: R
authors: Takahashi
authors: Nobuyuki
authors: N
authors: Yajima
authors: Tsuyoshi
authors: T
authors: Kasama
authors: Nanako
authors: N
authors: Takahashi
authors: Hirohiko
authors: H
authors: Sueki
authors: Sayaka
authors: S
authors: Yamaguchi
authors: Katsuhito
authors: K
authors: Arai
authors: Yoshiaki
authors: Y
authors: Takeuchi
authors: Nobuyuki
authors: N
authors: Ohike
authors: Tomoko
authors: T
authors: Norose
authors: Toshiko
authors: T
authors: Yamochi-Onizuka
authors: Masafumi
authors: M
authors: Takimoto
mesh_terms: D000368:Aged; D015938:Complement Membrane Attack Complex / Q000378:metabolism*; D017809:Fatal Outcome; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D054853:Malignant Atrophic Papulosis / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000378:metabolism / Q000473:pathology*
chemical_list: D015938:Complement Membrane Attack Complex
keywords: C5b-9 deposition; Degos disease