title: The association between prenatal exposure to organochlorine pesticides and thyroid hormone levels in newborns in Yancheng, China.
abstract: Organochlorine pesticides can interfere with the thyroid hormones that play an important role in early neurodevelopment. Although organochlorine pesticides have been banned in China since 1983, their residues are still detectable in the environment. However, few studies have investigated the adverse health effects of prenatal exposure to organochlorine pesticide residues on newborns in China. The present study, conducted in Yancheng City, Jiangsu Province, China, aimed to examine the association between the levels of organochlorine pesticides in maternal and cord sera and to assess the impact of prenatal exposure to organochlorine pesticides on thyroid hormone levels in cord serum. Eleven organochlorine pesticides in maternal and cord sera were measured in 247 mother-infant pairs recruited from Yancheng City between February 2010 and June 2010. The concentration of the thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) were determined in cord serum. Among the 11 tested organochlorine pesticides, the detectable levels of hexachlorobenzene (HCB), β-hexachlorocycolohexane (β-HCH) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) in both maternal and cord sera were above 50%. The levels of β-HCH and p,p'-DDE in maternal sera were positively associated with the levels in cord sera (r=0.421, P<0.01; r=0.288, P<0.01). After adjusting for confounders, the TSH level in cord serum samples was negatively associated with the HCB level (OR=0.535, 95% CI=(0.304-0.941)). Our data demonstrated that DDT, β-HCH and HCB residues bioconcentrate in maternal and cord sera. Moreover, the correlation analysis suggested that organochlorine pesticides in maternal blood can transfer through the placenta and affect newborn thyroid hormone levels.
authors: Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China.
authors: Chengcheng
authors: C
authors: Li
authors: Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China.
authors: Yibin
authors: Y
authors: Cheng
authors: Yancheng Municipal Center for Disease Control and Prevention, Yancheng 224002, Jiangsu, China.
authors: Quan
authors: Q
authors: Tang
authors: Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China.
authors: Shaobin
authors: S
authors: Lin
authors: Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China.
authors: Yonghong
authors: Y
authors: Li
authors: Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China.
authors: Xiaojian
authors: X
authors: Hu
authors: Yancheng Municipal Center for Disease Control and Prevention, Yancheng 224002, Jiangsu, China.
authors: Juan
authors: J
authors: Nian
authors: Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China.
authors: Heng
authors: H
authors: Gu
authors: Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China.
authors: Yifu
authors: Y
authors: Lu
authors: Yancheng Municipal Center for Disease Control and Prevention, Yancheng 224002, Jiangsu, China.
authors: Hong
authors: H
authors: Tang
authors: Yancheng Municipal Center for Disease Control and Prevention, Yancheng 224002, Jiangsu, China.
authors: Shougui
authors: S
authors: Dai
authors: Yancheng Municipal Center for Disease Control and Prevention, Yancheng 224002, Jiangsu, China.
authors: Hongqun
authors: H
authors: Zhang
authors: National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors: Cong
authors: C
authors: Jin
authors: Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China.
authors: Haijing
authors: H
authors: Zhang
authors: Yancheng Municipal Center for Disease Control and Prevention, Yancheng 224002, Jiangsu, China.
authors: Yuanyuan
authors: Y
authors: Jin
authors: Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing 100050, China. Electronic address: jinyinlong1951@sina.com.
authors: Yinlong
authors: Y
authors: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D002681:China; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D004785:Environmental Pollutants / Q000097:blood* / Q000633:toxicity; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood* / Q000633:toxicity; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D010575:Pesticides / Q000097:blood* / Q000633:toxicity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood* / Q000139:chemically induced; D013963:Thyroid Hormones / Q000097:blood*; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D013963:Thyroid Hormones
keywords: Newborns; Organochlorine pesticides; Pregnant women; Prenatal exposure; Thyroid hormone levels