title: Intestinal and hepatic Niemann-Pick C1L1 proteins: future therapeutic targets for cholesterol gallstones disease?
abstract: The formation of cholesterol gallstones is a very complex and polygenic disorder that involves an alteration of the secretion of bile lipids, cholesterol crystallization, important immunological reactions in the gallbladder tissue, formation of biliary sludge composed of mucin, and inadequate gallbladder motility. The search for a therapeutic target is oriented towards decreasing bile secretion and intestinal absorption of cholesterol, in which Niemann-Pick C1L1 (NPC1L1) proteins play an important role. In basic and clinical studies, regulating the expression of these proteins can reduce intestinal, liver, plasma and bile cholesterol levels, a therapeutic effect that would be useful not only for treating the disease, but to prevent it, given the large quantity of risk factors. We discuss these effects in this review and propose NPC1L1 proteins as future therapeutic targets of cholesterol gallstones disease.
authors: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, C.P. 04510, Delegación Coyoacán, México, D.F., México. Electronic address: ibrahim1002@hotmail.com.
authors: Ibrahim Guillermo
authors: IG
authors: Castro-Torres
authors: Área Académica de Farmacia, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca de Soto, Hidalgo, México.
authors: Minarda
authors: M
authors: De la O-Arciniega
authors: Facultad de Medicina "Lic. Miguel Alemán Valdés", Universidad Veracruzana, Veracruz, México.
authors: Gustavo Adolfo
authors: GA
authors: Bravo-Duarte
authors: Laboratorio de Productos Naturales, Instituto de Ciencias Básicas, Universidad Veracruzana, Xalapa de Enríquez, Veracruz, México.
authors: Janeth
authors: J
authors: Gallegos-Estudillo
authors: Laboratorio de Productos Naturales, Instituto de Ciencias Básicas, Universidad Veracruzana, Xalapa de Enríquez, Veracruz, México.
authors: Miguel Ángel
authors: MÁ
authors: Domínguez-Ortíz
authors: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior s/n, Ciudad Universitaria, C.P. 04510, Delegación Coyoacán, México, D.F., México.
authors: Mariano
authors: M
authors: Martínez-Vázquez
mesh_terms: D001692:Biological Transport; D002784:Cholesterol / Q000378:metabolism*; D042882:Gallstones / Q000209:etiology / Q000378:metabolism* / Q000628:therapy*; D015870:Gene Expression; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D026901:Membrane Transport Proteins; D058990:Molecular Targeted Therapy
chemical_list: D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C410800:NPC1L1 protein, human; D002784:Cholesterol
keywords: Cholesterol gallstones; Gallbladder; NPC1L1 proteins; Therapeutic target