title: The effects of acute pharmacological stimulation of the 5-HT, NA and DA systems on the cognitive judgement bias of rats in the ambiguous-cue interpretation paradigm.
abstract: In the present study, we investigated the effects of acute pharmacological stimulation of the serotonergic (5-HT), noradrenergic (NA) and dopaminergic (DA) systems on the valence of cognitive judgement bias of rats in the ambiguous-cue interpretation (ACI) paradigm. To accomplish this goal, after initial behavioural training, different groups of rats received single injections of citalopram, desipramine or d-amphetamine and were subsequently tested with the ACI paradigm. Each drug was administered in 3 doses using a fully randomised Latin square design. Citalopram at the dose of 1mg/kg significantly biased animals towards positive interpretation of the ambiguous cue, while at higher doses (5 and 10mg/kg), the animals interpreted the ambiguous cue more negatively. Desipramine at all 3 tested doses (1, 2 and 5mg/kg) significantly biased animals towards negative interpretation of the ambiguous cue, while d-amphetamine at the dose of 1mg/kg induced positive bias, having no effects at lower doses (0.1 and 0.5mg/kg). Our results indicate that cognitive bias in rats can be influenced by acute pharmacological intervention.
authors: Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland. Electronic address: rygula@gmail.com.
authors: Rafal
authors: R
authors: Rygula
authors: Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland.
authors: Justyna
authors: J
authors: Papciak
authors: Affective Cognitive Neuroscience Laboratory, Department of Behavioral Neuroscience and Drug Development, Institute of Pharmacology Polish Academy of Sciences, 12 Smetna Street, 31-343 Krakow, Poland; Faculty of Health Sciences, Collegium Medicum, Jagiellonian University, Michałowskiego 12, 31-126 Krakow, Poland.
authors: Piotr
authors: P
authors: Popik
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D015283:Citalopram / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D003463:Cues; D003891:Desipramine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D007600:Judgment / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
chemical_list: D018759:Adrenergic Uptake Inhibitors; D015283:Citalopram; D003891:Desipramine; D003913:Dextroamphetamine; D018765:Dopamine Uptake Inhibitors; D017367:Selective Serotonin Reuptake Inhibitors
keywords: Ambiguous-cue; Citalopram; Cognitive bias; Desipramine; Rat; d-Amphetamine