title: Hypoxia and hypoxia inducible factors in tumor metabolism.
abstract: Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this distinct microenvironment by shifting energy production from mitochondria towards glycolysis. In this review, we focus on the metabolism of tumor cell survival in hypoxic microenvironments. Furthermore, we also emphasize the mechanisms by which hypoxia and HIFs regulate tumor metabolism.
authors: Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 20025, China; Department of Joint and Bone Disease Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.
authors: Wen
authors: W
authors: Zeng
authors: Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 20025, China; Department of Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 20025, China.
authors: Peiyi
authors: P
authors: Liu
authors: Department of Human Movement Studies, Xi'an Physical Education University, Xi'an 710068, China.
authors: Weimin
authors: W
authors: Pan
authors: Mouse Cancer Genetics Program, Center for Cancer Research, National Institutes of Health, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: singhshr@mail.nih.gov.
authors: Shree Ram
authors: SR
authors: Singh
authors: Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases with Integrated Chinese-Western Medicine, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 20025, China; Department of Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 20025, China. Electronic address: dr.yiyongwei@yahoo.com.
authors: Yiyong
authors: Y
authors: Wei
mesh_terms: D017209:Apoptosis / Q000502:physiology; D015687:Cell Hypoxia; D002952:Citric Acid Cycle / Q000502:physiology; D004260:DNA Repair / Q000235:genetics; D004734:Energy Metabolism / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000502:physiology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism*; D050356:Lipid Metabolism; D008928:Mitochondria / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D059016:Tumor Microenvironment
chemical_list: D051793:Hypoxia-Inducible Factor 1; D005947:Glucose
keywords: Apoptosis; HIFs; Hypoxia; Metabolism; Tumor; Tumor microenvironment