title: Travoprost with sofZia® preservative system lowered intraocular pressure of Japanese normal tension glaucoma with minimal side effects.
abstract: BACKGROUND
  This study aimed to evaluate the effect of travoprost with sofZia® preservative system for lowering the intraocular pressure (IOP) of Japanese normal tension glaucoma (NTG) patients.
  
  
  METHODS
  In this prospective, multicenter, open-label study, Japanese NTG patients with baseline IOPs <20 mmHg were enrolled after three consecutive time measurements taken at screening and baseline visits. Travoprost with sofZia® was instilled once daily. Lowering effect on IOP, conjunctival hyperemia, superficial punctate keratopathy, and adverse events were examined at week 4, 8, and 12 after drug instillation.
  
  
  RESULTS
  One-hundred and three of the 107 enrolled patients (baseline IOP =15.2±2.0 mmHg [mean ± standard deviation]) completed the study. The mean IOP value as well as percent reduction was significantly reduced at each visit after travoprost with sofZia® initiation (P<0.0001). The conjunctival hyperemia score was 1 or less throughout the study, though it increased significantly over time. No significant change was observed in superficial punctate keratopathy. The cumulative incidence of side effects such as eyelash changes, eyelid pigmentation, and deepening of the upper lid was 47.6%, 27.2%, and 16.5%, respectively.
  
  
  CONCLUSIONS
  Travoprost preserved with sofZia® effectively lowered the IOP of Japanese NTG patients. It was well tolerated with few discontinuations due to adverse events.
authors: Department of Ophthalmology, Ehime University Graduate School of Medicine, Ehime, Japan.
authors: Shiro
authors: S
authors: Mizoue
authors: Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan.
authors: Tadashi
authors: T
authors: Nakano
authors: Department of Integrative Genomics, Tohoku Medical Megabank Organization, Miyagi, Japan.
authors: Nobuo
authors: N
authors: Fuse
authors: Tajimi Iwase Eye Clinic, Gifu, Japan.
authors: Aiko
authors: A
authors: Iwase
authors: Department of Ophthalmology, Tokyo Teishin Hospital, Tokyo, Japan.
authors: Shun
authors: S
authors: Matsumoto
authors: Yoshikawa Eye Clinic, Tokyo, Japan.
authors: Keiji
authors: K
authors: Yoshikawa
keywords: normal tension glaucoma (NTG); prostaglandin analogue; travoprost with sofZia® preservative system