title: Management of a patient with colon cancer and rotor syndrome: A case report.
abstract: Rotor Syndrome (RS) is a rare disease that is autosomal recessive and characterized by asymptomatic jaundice, conjugated hyperbilirubinemia and coproporphyria. RS occurs as a result of a complete lack or partial defect of organic anion transporter polypeptides (OATPs) on the basolateral surface of hepatocytes. OATPs facilitate the excretion of bilirubin and organic anions from the liver to the bile. To the best of our knowledge, there is no information in the literature relating to the treatment of a patient with colon cancer and RS. The present study aimed to discuss the systematic chemotherapy that is used and the effects on a 45-year-old patient who had RS with asymptomatic jaundice and was diagnosed with colon adenocarcinoma following surgery. The patient was administered oxaliplatin in combination with capecitabine. The patient's biluribin level increased after one week. Capecitabine treatment was interrupted and the patient was administered oxaliplatin monotherapy. No significant toxicity was observed during that period. At the latest follow-up the patient did not exhibit any progression.
authors: Department of Medical Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, Turkey.
authors: Deniz
authors: D
authors: Arslan
authors: Department of Medical Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, Turkey.
authors: Fatma
authors: F
authors: Avci
authors: Department of Medical Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, Turkey.
authors: Alparslan
authors: A
authors: Merdin
authors: Department of Medical Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, Turkey.
authors: Seyda
authors: S
authors: Gunduz
authors: Department of Medical Oncology, Akdeniz University Faculty of Medicine, Antalya 07070, Turkey.
authors: Hasan Senol
authors: HS
authors: Coskun
keywords: capecitabine; chemotherapy; colon carcinoma; oxaliplatin; rotor syndrome