title: Anticancer and antitumor potential of fucoidan and fucoxanthin, two main metabolites isolated from brown algae.
abstract: Seaweed is one of the largest producers of biomass in marine environment and is a rich arsenal of active metabolites and functional ingredients with valuable beneficial health effects. Being a staple part of Asian cuisine, investigations on the crude extracts of Phaeophyceae or brown algae revealed marked antitumor activity, eliciting a variety of research to determine the active ingredients involved in this potential. The sulfated polysaccharide of fucoidan and carotenoid of fucoxanthin were found to be the most important active metabolites of brown algae as potential chemotherapeutic or chemopreventive agents. This review strives to provide detailed account of all current knowledge on the anticancer and antitumor activity of fucoidan and fucoxanthin as the two major metabolites isolated from brown algae.
authors: Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Soheil
authors: S
authors: Zorofchian Moghadamtousi
authors: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Hamed
authors: H
authors: Karimian
authors: Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Ramin
authors: R
authors: Khanabdali
authors: Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Mahboubeh
authors: M
authors: Razavi
authors: Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Mohammad
authors: M
authors: Firoozinia
authors: Department of Medical Microbiology, Tropical Infectious Disease Research and Education Center (TIDREC), Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Keivan
authors: 0000-0001-5107-8754
authors: K
authors: Zandi
authors: Biochemistry Program, Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors: Habsah
authors: H
authors: Abdul Kadir
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000378:metabolism* / Q000627:therapeutic use; D002051:Burkitt Lymphoma / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D019169:Jurkat Cells; D020014:K562 Cells; D000459:Phaeophyceae / Q000378:metabolism*; D011134:Polysaccharides / Q000302:isolation & purification / Q000378:metabolism* / Q000627:therapeutic use; D024341:Xanthophylls / Q000302:isolation & purification / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D011134:Polysaccharides; D024341:Xanthophylls; C025164:fucoxanthin; C007789:fucoidan