title: Statin-associated necrotizing autoimmune myopathy.
abstract: Necrotizing autoimmune myopathy (NAM) is a severe adverse effect of statins. We report a 66-year-old Caucasian female who had progressive proximal muscle weakness after treatment with statins. Results of a muscle biopsy showed necrotizing myopathy with minimal inflammatory cell infiltrate and increased major histocompatibility class I antigen expression in muscle fibers. The clinical and laboratory parameters improved significantly with immunosuppressive treatment. Although it is a rare event, statin-induced NAM should be included as a differential diagnosis of myopathies.
authors: Division of Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo , São Paulo , Brazil.
authors: Geórgea Hermogenes
authors: GH
authors: Fernandes
authors: Edmar
authors: E
authors: Zanoteli
authors: Samuel Katsuyuki
authors: SK
authors: Shinjo
mesh_terms: D000368:Aged; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy; D018482:Muscle, Skeletal / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Dyslipidemia; Myopathy; Myositis; Necrotizing autoimmune myopathy; Statin