title: The emerging role of mTOR signalling in antibacterial immunity.
abstract: Mammalian target of rapamycin (mTOR) is a central regulator of cellular metabolic homeostasis that is highly conserved in evolution. Recent evidence has revealed the existence of a complex interplay between mTOR signalling and immunity. We review here the emerging role of mTOR signalling in the regulation of Toll-like receptor-dependent innate responses and in the activation of T cells and antigen-presenting cells. We also highlight the importance of amino-acid starvation-driven mTOR inhibition in the control of autophagy and intracellular bacterial clearance.
authors: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
authors: Mena
authors: M
authors: Abdel-Nour
authors: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
authors: Jessica
authors: J
authors: Tsalikis
authors: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
authors: David
authors: D
authors: Kleinman
authors: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
authors: Stephen E
authors: SE
authors: Girardin
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007109:Immunity / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D051193:Toll-Like Receptors; D058570:TOR Serine-Threonine Kinases