title: Agarose drug delivery systems upgraded by surfactants inclusion: critical role of the pore architecture.
abstract: Anionic or non-ionic surfactants have been introduced in agarose-based hydrogels aiming to tailor the release of drugs with different solubility. The release of a hydrophilic model drug, Theophylline, shows the predictable release enhancement that varies depending on the surfactant. However, when the hydrophobic Tolbutamide is considered, an unexpected retarded release is observed. This effect can be explained not only considering the interactions established between the drug loaded micelles and agarose but also to the alteration of the freeze-dried hydrogels microstructure. It has been observed that the modification of the porosity percentage as well as the pore size distribution during the lyophilization plays a critical role in the different phenomena that take place as soon as desiccated hydrogel is rehydrated. The possibility of tailoring the pore architecture as a function of the surfactant nature and percentage can be applied from drug control release to the widespread and growing applications of materials based on hydrogel matrices.
authors: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain. Electronic address: tmarrasm@ucm.es.
authors: T
authors: T
authors: Marras-Marquez
authors: Departamento de Química Inorgánica y Bioinorgánica Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain. Electronic address: juanpena@ucm.es.
authors: J
authors: J
authors: Peña
authors: Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain. Electronic address: mdveiga@ucm.es.
authors: M D
authors: MD
authors: Veiga-Ochoa
mesh_terms: D016503:Drug Delivery Systems; D020100:Hydrogels / Q000737:chemistry; D012685:Sepharose / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*
chemical_list: D020100:Hydrogels; D013501:Surface-Active Agents; D012685:Sepharose
keywords: Drug-controlled release; Hydrogels; Microstructure; Pore architecture; Surfactant