title: Interleukin 12B rs3212227 T > G polymorphism was associated with an increased risk of gastric cardiac adenocarcinoma in a Chinese population.
abstract: Gastric cardiac adenocarcinoma (GCA) is one of common malignant tumors in the world. Multiple genes that play critical roles in inflammatory pathways probably are associated with GCA risk. We conducted a hospital-based case-control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs): interleukin 9 (IL9) rs31563 C > T, IL9 rs31564 G > T, IL10 rs1800872 T > G, IL12A rs2243115 T > G, IL12B rs3212227 T > G, and IL13 rs1800925 C > T on the development of GCA. Two hundred and forty-three GCA cases and 476 controls were recruited. Their genotypes were determined using a custom-by-design 48-Plex SNPscan kit. IL12B rs3212227 T > G polymorphism was associated with the increased risk of GCA. However, there was no significant association between the other five SNPs and GCA risk. Stratified analyses indicated that the risk of GCA associated with the IL12B rs3212227 T > G polymorphism was evident among female patients and patients who never smoked or consumed alcoholic drinks. These findings indicated that functional polymorphism IL12B rs3212227 T > G might correlate with GCA risk. However, our results were obtained with a limited sample size; the power of our analysis was low. Larger studies are required to confirm the current findings.
authors: Department of Cardiothoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors: J
authors: J
authors: Yin
authors: X
authors: X
authors: Wang
authors: J
authors: J
authors: Wei
authors: L
authors: L
authors: Wang
authors: Y
authors: Y
authors: Shi
authors: L
authors: L
authors: Zheng
authors: W
authors: W
authors: Tang
authors: G
authors: G
authors: Ding
authors: C
authors: C
authors: Liu
authors: R
authors: R
authors: Liu
authors: S
authors: S
authors: Chen
authors: Z
authors: Z
authors: Xu
authors: H
authors: H
authors: Gu
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D000368:Aged; D000428:Alcohol Drinking; D002299:Cardia; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40
keywords: IL12B; gastric cardiac adenocarcinoma; molecular epidemiology; polymorphism