title: Chorioamnionitis in the pathogenesis of brain injury in preterm infants.
abstract: Chorioamnionitis (or placental infection) is suspected to be a risk factor for brain injury in premature infants. The suggested association between chorioamnionitis and cystic periventricular leukomalacia and cerebral palsy is uncertain because of the variability of study designs and definitions of chorioamnionitis. Improvements in neonatal intensive care may have attenuated the impact of chorioamnionitis on brain health outcomes. Large multicenter studies using rigorous definitions of chorioamnionitis on placental pathologies and quantitative magnetic resonance techniques may offer the optimal way to clarify the complex role of chorioamnionitis in modifying brain health and long-term outcomes.
authors: Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada; University of Toronto, Department of Pediatrics, 563 Spadina Crescent, Toronto, Ontario, M5S 2J7, Canada; Child & Family Research Institute, 950 28th Avenue, Vancouver, British Columbia, V5Z 4H4, Canada. Electronic address: vann.chau@sickkids.ca.
authors: Vann
authors: V
authors: Chau
authors: Child & Family Research Institute, 950 28th Avenue, Vancouver, British Columbia, V5Z 4H4, Canada; Department of Pathology, BC Children's & Women's Health Center, 4480 Oak Street, Vancouver, British Columbia, V6H 3V4, Canada; University of British Columbia, Departments of Pediatrics, Pathology and Radiology, 2329 West Mall, Vancouver, British Columbia, V6T 1Z4, Canada.
authors: Deborah E
authors: DE
authors: McFadden
authors: Child & Family Research Institute, 950 28th Avenue, Vancouver, British Columbia, V5Z 4H4, Canada; University of British Columbia, Departments of Pediatrics, Pathology and Radiology, 2329 West Mall, Vancouver, British Columbia, V6T 1Z4, Canada; Departments of Pediatrics and Radiology, BC Children's & Women's Health Center, 4480 Oak Street, Vancouver, British Columbia, V6H 3V4, Canada.
authors: Kenneth J
authors: KJ
authors: Poskitt
authors: Division of Neurology, Department of Pediatrics, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada; Neurosciences and Mental Health Program, Research Institute, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada; University of Toronto, Department of Pediatrics, 563 Spadina Crescent, Toronto, Ontario, M5S 2J7, Canada; Child & Family Research Institute, 950 28th Avenue, Vancouver, British Columbia, V5Z 4H4, Canada.
authors: Steven P
authors: SP
authors: Miller
mesh_terms: D001930:Brain Injuries / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D002547:Cerebral Palsy / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D002821:Chorioamnionitis / Q000276:immunology / Q000503:physiopathology*; D016207:Cytokines / Q000276:immunology; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D018836:Inflammation Mediators / Q000276:immunology; D007969:Leukomalacia, Periventricular / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D009413:Nerve Fibers, Myelinated / Q000276:immunology*; D011247:Pregnancy; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators
keywords: Cerebral palsy; Diffusion tensor imaging; Magnetic resonance imaging; Magnetic resonance spectroscopic imaging; Neurodevelopment; Placental infection; White matter injury