title: Engineering physical microenvironment for stem cell based regenerative medicine.
abstract: Regenerative medicine has rapidly evolved over the past decade owing to its potential applications to improve human health. Targeted differentiations of stem cells promise to regenerate a variety of tissues and/or organs despite significant challenges. Recent studies have demonstrated the vital role of the physical microenvironment in regulating stem cell fate and improving differentiation efficiency. In this review, we summarize the main physical cues that are crucial for controlling stem cell differentiation. Recent advances in the technologies for the construction of physical microenvironment and their implications in controlling stem cell fate are also highlighted.
authors: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, 710049, China; Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Shaanxi, 710049, China.
authors: Yu Long
authors: YL
authors: Han
authors: Brigham Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors: Shuqi
authors: S
authors: Wang
authors: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, 710049, China; Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Shaanxi, 710049, China.
authors: Xiaohui
authors: X
authors: Zhang
authors: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, 710049, China; Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Shaanxi, 710049, China.
authors: Yuhui
authors: Y
authors: Li
authors: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, 710049, China; Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Shaanxi, 710049, China.
authors: Guoyou
authors: G
authors: Huang
authors: Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Shaanxi, 710049, China.
authors: Hao
authors: H
authors: Qi
authors: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, 50603, Malaysia.
authors: Belinda
authors: B
authors: Pingguan-Murphy
authors: State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and training Center, Beijing, 100094, China.
authors: Yinghui
authors: Y
authors: Li
authors: Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Shaanxi, 710049, China. Electronic address: tjlu@mail.xjtu.edu.cn.
authors: Tian Jian
authors: TJ
authors: Lu
authors: The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Shaanxi, 710049, China; Bioinspired Engineering & Biomechanics Center, Xi'an Jiaotong University, Shaanxi, 710049, China. Electronic address: fengxu@mail.xjtu.edu.cn.
authors: Feng
authors: F
authors: Xu
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D044968:Regenerative Medicine / Q000379:methods*; D055153:Stem Cell Niche / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*