title: Redox regulation of cardiac hypertrophy.
abstract: It is increasingly evident that redox-dependent modifications in cellular proteins and signaling pathways (or redox signaling) play important roles in many aspects of cardiac hypertrophy. Indeed, these redox modifications may be intricately linked with the process of hypertrophy wherein there is not only a significant increase in myocardial O2 consumption but also important alterations in metabolic processes and in the local generation of O2-derived reactive species (ROS) that modulate and/or amplify cell signaling pathways. This article reviews our current knowledge of redox signaling pathways and their roles in cardiac hypertrophy. This article is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System".
authors: King's College London British Heart Foundation Centre of Excellence, Cardiovascular Division, London, UK.
authors: Can M
authors: CM
authors: Sag
authors: King's College London British Heart Foundation Centre of Excellence, Cardiovascular Division, London, UK.
authors: Celio X C
authors: CX
authors: Santos
authors: King's College London British Heart Foundation Centre of Excellence, Cardiovascular Division, London, UK. Electronic address: ajay.shah@kcl.ac.uk.
authors: Ajay M
authors: AM
authors: Shah
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism*; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism*; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D017382:Reactive Oxygen Species; D019255:NADPH Oxidases
keywords: Cardiac; Hypertrophy; NADPH oxidase; Redox; Signaling