title: Behavioral changes of zebrafish according to cisplatin-induced toxicity of the balance system.
abstract: OBJECTIVE
  Zebrafish are commonly used as experimental animals in otolaryngology studies. However, the behavioral characteristics of these fish are not well known, especially those related to the vestibular system. The goal of this study was to evaluate behavioral changes in zebrafish due to toxicity in the balance system.
  
  
  METHODS
  Zebrafish were exposed to 1000 μM cisplatin for 6 h. We, then, periodically monitored swimming depth, total swimming distance, peak swimming velocity, and mean swimming velocity of the fish for approximately 21 days.
  
  
  RESULTS
  Total swimming distance (p < 0.0001), peak swimming velocity (p = 0.0063), and mean swimming velocity (p < 0.0001) in the cisplatin-administered group were significantly decreased when compared with control fish.
  
  
  CONCLUSIONS
  Our findings demonstrate that cisplatin can alter the locomotion behavior of zebrafish.
authors: Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, South Korea.
authors: M J
authors: MJ
authors: Kim
authors: Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Korea University, Ahn San, South Korea.
authors: J
authors: J
authors: Choi
authors: Neuroscience Research Institute, Graduate School of Medicine, Gachon University, Incheon, South Korea.
authors: N
authors: N
authors: Kim
authors: Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Gachon University of Medicine and Science, Incheon, South Korea hangckr@gmail.com.
authors: G C
authors: GC
authors: Han
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects*; D002945:Cisplatin / Q000633:toxicity*; D008465:Mechanoreceptors / Q000187:drug effects / Q000473:pathology; D013550:Swimming; D015027:Zebrafish
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: Zebrafish; behavior; cisplatin; toxicity; vestibule of ear