title: Biomaterial and mesenchymal stem cell for articular cartilage reconstruction.
abstract: Cartilage has poor ability of spontaneous repair. Traditional treatments such as microfracture, bone drilling and autologous osteochondral graft were not fully satisfactory to fulfill the clinical needs. The idea of mesenchymal stem cell (MSCs-based cartilage regeneration has been put forward for decades. Large number of studies have been conducted on the biological properties of MSCs, the factors which might facilitate chondrogenic differentiation of MSCs, as well as the scaffold materials for tissue engineering. Promising results have been reported for cartilage repair in animal models. But before massive clinical application of MSCs, more efforts are needed on: differentiation improvement toward mature cartilage chondrocytes instead of hypertrophic chondrocyes and in vitro/in vivo phenotype maintenance; engineering an ideal biomaterial, which can meet the needs of the cartilage regeneration; and performing more studies on critical defects of large animals.
authors: Yun
authors: Y
authors: Shen
authors: Yao
authors: Y
authors: Fu
authors: Jing
authors: J
authors: Wang
authors: Guo
authors: G
authors: Li
authors: Xu
authors: X
authors: Zhang
authors: Yuanzhi
authors: Y
authors: Xu
authors: Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Middle Yanchang Road, Shanghai 200072, P.R. China. amyxyz01@hotmail.com.
authors: Yunfeng
authors: Y
authors: Lin
mesh_terms: D000328:Adult; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D002357:Cartilage Diseases / Q000628:therapy*; D002358:Cartilage, Articular / Q000166:cytology*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials