title: Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice.
abstract: Trimethylolpropane triacrylate (TMPTA) is a multifunctional monomer with industrial applications. To determine the carcinogenic potential, male and female F344/N rats and B6C3F1/N mice were administered TMPTA (0, 0.3, 1.0, or 3.0mg/kg) in acetone dermally for 2 years. There were no differences in the body weights and survival in the treated animals compared to controls. Nonneoplastic skin lesions at the site of application included epidermal hyperplasia and hyperkeratosis in both rats and mice. There were no incidences of tumors at the site of application in rats and mice. Rare malignant liver neoplasms were observed in female mice that included hepatoblastoma in the 0.3 and 3.0mg/kg groups, and hepatocholangiocarcinoma in the 1.0 and 3.0mg/kg groups. The incidences of uterine stromal polyp and stromal polyp or stromal sarcoma (combined) in female mice occurred with positive trends and the incidences were significantly increased in the 3.0mg/kg group. A marginal increase in the incidences of malignant mesothelioma in male rats may have been related to TMPTA treatment. In conclusion, our studies show that TMPTA is a dermal irritant in both rats and mice of either sex. Increased incidences of tumor formation were observed in female mice and male rats.
authors: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address: surhi@niehs.nih.gov.
authors: Inok
authors: I
authors: Surh
authors: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA; Integrated Laboratory Systems, Inc., Research Triangle Park, NC 27709, USA.
authors: Deepa B
authors: DB
authors: Rao
authors: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors: Mark F
authors: MF
authors: Cesta
authors: Southern Research Institute, Birmingham, AL 35255, USA.
authors: Charles D
authors: CD
authors: Hébert
authors: Southern Research Institute, Birmingham, AL 35255, USA.
authors: Jill F
authors: JF
authors: Mann
authors: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors: Helen
authors: H
authors: Cunny
authors: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors: Grace E
authors: GE
authors: Kissling
authors: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors: David
authors: D
authors: Malarkey
authors: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA.
authors: Rajendra S
authors: RS
authors: Chhabra
mesh_terms: D000179:Acrylates / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors; D013045:Species Specificity
chemical_list: D000179:Acrylates; D002273:Carcinogens; C027993:trimethylolpropane triacrylate
keywords: Carcinogenicity; Liver; Skin; Trimethylolpropane triacrylate; Uterine