title: Successful treatment of infantile fibrosarcoma spinal metastasis by chemotherapy and stereotactic hypofractionated radiotherapy.
abstract: We report a case of infantile fibrosarcoma in an 8-month-old boy manifested as a right-sided lower leg mass. Repeated local recurrence and distant metastasis were noted during the following three-year period. Whole body fluoro-deoxyglucose positron emission tomography scan revealed an asymptomatic metastasis involving the fourth lumbar vertebrae. The patient received chemotherapy (VAC regimen) with Cyberknife® stereotactic hypofractionated radiotherapy (26 Gy; 4 fractions). This treatment reduced tumor size by 23% without acute radiation toxicity even after 33 months. This case suggests that combining chemotherapy and this form of radiotherapy may be safe and effective against childhood spinal metastasis.
authors: Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC.
authors: Cheng-Hsiang
authors: CH
authors: Lo
authors: Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC.
authors: Shin-Nan
authors: SN
authors: Cheng
authors: Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC.
authors: Kuen-Tze
authors: KT
authors: Lin
authors: Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taiwan, ROC.
authors: Yee-Min
authors: YM
authors: Jen
keywords: Cyberknife®; Hypofractionated radiotherapy; Infantile fibrosarcoma; Spinal metastasis