title: Galectin-7 as a potential predictive marker of chemo- and/or radio-therapy resistance in oral squamous cell carcinoma.
abstract: Treatment of advanced oral squamous cell carcinoma (OSCC) requires the integration of multimodal approaches. The aim of this study was to identify predictors of tumor sensitivity to preoperative radiotherapy/chemotherapy for OSCC in order to allow oncologists to determine optimum therapeutic strategies without the associated adverse effects. Here, the protein expression profiles of formalin-fixed paraffin-embedded (FFPE) tissue samples from 18 OSCC patients, termed learning cases, who received preoperative chemotherapy and/or radiotherapy followed by surgery were analyzed by quantitative proteomics and validated by immunohistochemistry in 68 test cases as well as in the 18 learning cases. We identified galectin-7 as a potential predictive marker of chemotherapy and/or radiotherapy resistance, and the sensitivity and specificity of the galectin-7 prediction score (G7PS) in predicting this resistance was of 96.0% and 39.5%, respectively, in the 68 test cases. The cumulative 5-year disease-specific survival rate was 75.2% in patients with resistant prediction using G7PS and 100% in patients with sensitive prediction. In vitro overexpression of galectin-7 significantly decreased cell viability in OSCC cell line. Therefore, our findings suggest that galectin-7 is a potential predictive marker of chemotherapy and/or radiotherapy resistance in patients with OSCC.
authors: Oral and Maxillofacial Surgery, Department of Oral Health Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.
authors: Sho
authors: S
authors: Matsukawa
authors: Kei-ichi
authors: K
authors: Morita
authors: Ayako
authors: A
authors: Negishi
authors: Hiroyuki
authors: H
authors: Harada
authors: Yusuke
authors: Y
authors: Nakajima
authors: Hiroaki
authors: H
authors: Shimamoto
authors: Hirofumi
authors: H
authors: Tomioka
authors: Kae
authors: K
authors: Tanaka
authors: Masaya
authors: M
authors: Ono
authors: Tesshi
authors: T
authors: Yamada
authors: Ken
authors: K
authors: Omura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000096:biosynthesis; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy; D002853:Chromatography, Liquid; D005260:Female; D037161:Galectins / Q000032:analysis* / Q000096:biosynthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy; D011237:Predictive Value of Tests; D040901:Proteomics / Q000379:methods; D012189:Retrospective Studies; D053719:Tandem Mass Spectrometry
chemical_list: D014408:Biomarkers, Tumor; D037161:Galectins; C092525:LGALS7 protein, human
keywords: Formalin-fixed paraffin-embedded; galectin-7; liquid chromatography and mass spectrometry; oral squamous cell carcinoma