title: Cardiac troponins and high-sensitivity cardiac troponin assays.
abstract: Measurement of circulating cardiac troponins I and T has become integral to the diagnosis of myocardial infarction. This article discusses the structure and function of the troponin complex and the release of cardiac troponin molecules from the injured cardiomyocyte into the circulation. An overview of current cardiac troponin assays and their classification according to sensitivity is presented. The diagnostic criteria, role, and usefulness of cardiac troponin for myocardial infarction are discussed. In addition, several examples are given of the usefulness of high-sensitivity cardiac troponin assays for short-term and long-term prediction of adverse events.
authors: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Harvard Medical School, Boston, MA 02115, USA.
authors: Michael J
authors: MJ
authors: Conrad
authors: Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Harvard Medical School, Boston, MA 02115, USA. Electronic address: pjarolim@partners.org.
authors: Petr
authors: P
authors: Jarolim
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis*; D006801:Humans; D009203:Myocardial Infarction / Q000175:diagnosis*; D011379:Prognosis; D011499:Protein Processing, Post-Translational; D014336:Troponin / Q000097:blood* / Q000235:genetics
chemical_list: D014336:Troponin
keywords: Acute myocardial infarction; Adverse event; Biomarker; Cardiac markers; Cardiac troponin; High-sensitivity assay; Risk prediction