title: Fourier transform ion cyclotron resonance (FT ICR) mass spectrometry: Theory and simulations.
abstract: Fourier transform ion cyclotron resonance (FT ICR) mass spectrometer offers highest resolving power and mass accuracy among all types of mass spectrometers. Its unique analytical characteristics made FT ICR important tool for proteomics, metabolomics, petroleomics, and investigation of complex mixtures. Signal acquisition in FT ICR MS takes long time (up to minutes). During this time ion-ion interaction considerably affects ion motion and result in decreasing of the resolving power. Understanding of those effects required complicated theory and supercomputer simulations but culminated in the invention of the ion trap with dynamic harmonization which demonstrated the highest resolving power ever achieved. In this review we summarize latest achievements in theory and simulation of FT ICR mass spectrometers.
authors: Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninskij pr. 38 k. 2, 119334, Moscow, Russia.|Emanuel Institute for Biochemical Physics, Russian Academy of Sciences, Kosygina st. 4, 119334, Moscow, Russia.|Moscow Institute of Physics and Technology, 141700, Dolgoprudnyi, Moscow Region, Russia.|Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, ul. Pogodinskaya 10, 119121, Moscow, Russia.
authors: Eugene N
authors: EN
authors: Nikolaev
authors: Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninskij pr. 38 k. 2, 119334, Moscow, Russia.|Moscow Institute of Physics and Technology, 141700, Dolgoprudnyi, Moscow Region, Russia.
authors: Yury I
authors: YI
authors: Kostyukevich
authors: Institute for Energy Problems of Chemical Physics, Russian Academy of Sciences, Leninskij pr. 38 k. 2, 119334, Moscow, Russia.
authors: Gleb N
authors: GN
authors: Vladimirov
keywords: FT ICR; MS; non-neutral plasma; simulation