title: Gusperimus: immunological mechanism and clinical applications.
abstract: Gusperimus is an immunosuppressive drug with a unique mode of action. We review its effects on different arms of the immune system and the current evidence for clinical applications, particularly in the treatment of transplant rejection and ANCA-associated vasculitis.
authors: Medical Sciences Division, University of Oxford, Oxford, Lupus and Vasculitis Clinic, Addenbrookes Hospital, Cambridge and Department of Nephrology, Royal Berkshire Hospital, Reading, UK.
authors: Miklos
authors: M
authors: Perenyei
authors: Medical Sciences Division, University of Oxford, Oxford, Lupus and Vasculitis Clinic, Addenbrookes Hospital, Cambridge and Department of Nephrology, Royal Berkshire Hospital, Reading, UK.
authors: David R W
authors: DR
authors: Jayne
authors: Medical Sciences Division, University of Oxford, Oxford, Lupus and Vasculitis Clinic, Addenbrookes Hospital, Cambridge and Department of Nephrology, Royal Berkshire Hospital, Reading, UK. oflossmann@doctors.org.uk.
authors: Oliver
authors: O
authors: Floßmann
mesh_terms: D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000188:drug therapy* / Q000276:immunology; D006084:Graft Rejection / Q000188:drug therapy* / Q000276:immunology; D006146:Guanidines / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D006146:Guanidines; D007166:Immunosuppressive Agents; C037258:gusperimus
keywords: deoxyspergualin; glomerulonephritis; gusperimus; immune suppressant; rejection; systemic lupus erythematosus; transplantation; vasculitis