title: Vancomycin-variable Enterococcus faecium: in vivo emergence of vancomycin resistance in a vancomycin-susceptible isolate.
abstract: We report the emergence of vancomycin resistance in a patient colonized with a vanA-containing, vanRS-negative isolate of Enterococcus faecium which was initially vancomycin susceptible. This is a previously undescribed mechanism of drug resistance with diagnostic and therapeutic implications.
authors: Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Canada.
authors: Bryan
authors: B
authors: Coburn
authors: Donald E
authors: DE
authors: Low
authors: Samir N
authors: SN
authors: Patel
authors: Susan M
authors: SM
authors: Poutanen
authors: Dea
authors: D
authors: Shahinas
authors: Alireza
authors: A
authors: Eshaghi
authors: Barbara M
authors: BM
authors: Willey
authors: Allison
authors: A
authors: McGeer
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000235:genetics; D016984:Enterococcus faecium / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D005798:Genes, Bacterial / Q000235:genetics; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D014640:Vancomycin / Q000627:therapeutic use*; D020713:Vancomycin Resistance / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D014640:Vancomycin