title: Serotonin reuptake inhibitors in pregnancy: can genes help us in predicting neonatal adverse outcome?
abstract: Lots has been written on use of SSRI during pregnancy and possible short and long term negative outcomes on neonates. the literature so far has described a various field of peripartum illness related to SSRI exposure during foetal life, such as increased incidence of low birth weight, respiratory distress, persistent pulmonary hypertension, poor feeding, and neurobehavioural disease. We know that different degrees of outcomes are possible, and not all the newborns exposed to SSRIs during pregnancy definitely will develop a negative outcome. So far, still little is known about the possible etiologic mechanism that could not only explain the adverse neonatal effects but also the degree of clinical involvement and presentation in the early period after birth. Pharmacogenetics and moreover pharmacogenomics, the study of specific genetic variations and their effect on drug response, are not widespread. This review describes possible relationship between SSRIs pharmacogenetics and different neonatal outcomes and summarizes the current pharmacogenetic inquiries in relation to maternal-foetal environment.
authors: Department of Paediatrics, Hospital Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy.
authors: Valentina
authors: V
authors: Giudici
authors: Department of Paediatrics, Hospital Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy.
authors: Laura
authors: L
authors: Pogliani
authors: Unit of Clinical Pharmacology, Hospital Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy.
authors: Dario
authors: D
authors: Cattaneo
authors: Department of Paediatrics, Hospital Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy.
authors: Dario
authors: D
authors: Dilillo
authors: Department of Paediatrics, Hospital Luigi Sacco, Via GB Grassi 74, 20157 Milan, Italy.
authors: Gian Vincenzo
authors: GV
authors: Zuccotti
mesh_terms: D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D010597:Pharmacogenetics; D011247:Pregnancy; D011256:Pregnancy Outcome; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors