title: Highly potent HCV NS4B inhibitors with activity against multiple genotypes.
abstract: The exploration of novel inhibitors of the HCV NS4B protein that are based on a 2-oxadiazoloquinoline scaffold is described. Optimization to incorporate activity across genotypes led to a potent new series with broad activity, of which inhibitor 1 displayed the following EC50 values: 1a, 0.08 nM; 1b, 0.10 nM; 2a, 3 nM; 2b, 0.6 nM, 3a, 3.7 nM; 4a, 0.9 nM; 6a, 3.1 nM.
authors: Gilead Sciences , 333 Lakeside Drive, Foster City, California 94404, United States.
authors: Barton
authors: B
authors: Phillips
authors: Ruby
authors: R
authors: Cai
authors: William
authors: W
authors: Delaney
authors: Zhimin
authors: Z
authors: Du
authors: Mingzhe
authors: M
authors: Ji
authors: Haolun
authors: H
authors: Jin
authors: Johnny
authors: J
authors: Lee
authors: Jiayao
authors: J
authors: Li
authors: Anita
authors: A
authors: Niedziela-Majka
authors: Michael
authors: M
authors: Mish
authors: Hyung-Jung
authors: HJ
authors: Pyun
authors: Joe
authors: J
authors: Saugier
authors: Neeraj
authors: N
authors: Tirunagari
authors: Jianhong
authors: J
authors: Wang
authors: Huiling
authors: H
authors: Yang
authors: Qiaoyin
authors: Q
authors: Wu
authors: Chris
authors: C
authors: Sheng
authors: Catalin
authors: C
authors: Zonte
mesh_terms: D005838:Genotype; D016174:Hepacivirus / Q000187:drug effects* / Q000235:genetics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*
chemical_list: C080107:NS4B protein, flavivirus; D017361:Viral Nonstructural Proteins