title: Decreased levels of lipoxin A4 and annexin A1 in wheezy infants.
abstract: OBJECTIVE
  Wheezing is a common and challenging health issue in infancy and early childhood. Asthma diagnosis is frequent in patients with a history of recurrent wheezing. A relationship has been reported between asthma and anti-inflammatory mediators such as lipoxin A4 and annexin A1. However, this remains uncertain in wheezy infants. The aim of the present study was to determine lipoxin A4 and annexin A1 levels in wheezy infants.
  
  
  METHODS
  Eighty-seven patients aged 6-36 months were included in this study. Demographic characteristics, clinical features, laboratory data, clinical diagnoses, and treatments, if present, were recorded. Patients were divided into 2 groups: patients with wheezing (n = 59) and healthy controls (n = 28). Blood samples were taken and lipoxin A4 and annexin A1 levels were evaluated by ELISA.
  
  
  RESULTS
  Lipoxin A4 and annexin A1 levels were significantly lower in the wheezing group than in the control group (p < 0.05). A significant correlation was found between the serum total immunoglobulin E (IgE) level and the percentage and absolute number of eosinophils (p < 0.05). No significant correlation was found in terms of lipoxin A4 and annexin A1 levels, the serum total IgE level, and the percentage and absolute number of eosinophils among groups (p > 0.05).
  
  
  CONCLUSIONS
  This is the first study to assess lipoxin A4 and annexin A1 levels in wheezy infants. The levels of lipoxin A4 and annexin A1 were found to be low in wheezy infants. We hope that these results will lead to novel therapeutic options for asthma in cases where an optimal treatment modality is lacking.
authors: Department of Pediatric Allergy, Erciyes University School of Medicine, Kayseri, Turkey.
authors: Hatice
authors: H
authors: Eke Gungor
authors: Fulya
authors: F
authors: Tahan
authors: Selma
authors: S
authors: Gokahmetoglu
authors: Berkay
authors: B
authors: Saraymen
mesh_terms: D017305:Annexin A1 / Q000097:blood*; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007223:Infant; D044045:Lipoxins / Q000097:blood*; D008297:Male; D012135:Respiratory Sounds / Q000276:immunology*
chemical_list: D017305:Annexin A1; D044045:Lipoxins; C040527:lipoxin A4