title: Persistent babesiosis in a Rhesus macaque (Macaca mulatta) infected with a simian-human immunodeficiency virus.
abstract: BACKGROUND
  A rhesus macaque developed chronic anemia, lymphocytic leukocytopenia, fever, and anorexia while immunodeficient following inoculation with a simian-human immunodeficiency virus.
  
  
  METHODS
  A complete blood count, peripheral blood smear, polymerase chain reaction and gene sequence were performed.
  
  
  RESULTS
  Blood smears demonstrated persistent intraerythrocytic piroplasms with rare Maltese cross forms. Babesia microti-like protozoa were confirmed by polymerase chain reaction and sequencing of the 18S ribosomal RNA gene.
  
  
  CONCLUSIONS
  With continued use of non-human primates as models for human diseases, infection and complications from babesiosis should be monitored.
authors: Division of Comparative Pathology, Tulane National Primate Research Center, Covington, LA, USA.
authors: David X
authors: DX
authors: Liu
authors: Amy
authors: A
authors: Gill
authors: Patricia J
authors: PJ
authors: Holman
authors: Peter J
authors: PJ
authors: Didier
authors: James L
authors: JL
authors: Blanchard
authors: Ronald S
authors: RS
authors: Veazey
authors: Andrew A
authors: AA
authors: Lackner
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D041001:Babesia microti / Q000235:genetics / Q000302:isolation & purification*; D001404:Babesiosis / Q000175:diagnosis* / Q000469:parasitology; D016054:DNA, Protozoan / Q000235:genetics; D005260:Female; D015497:HIV-1 / Q000502:physiology; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000175:diagnosis* / Q000469:parasitology / Q000821:virology; D016133:Polymerase Chain Reaction; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D017422:Sequence Analysis, DNA; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000502:physiology
chemical_list: D016054:DNA, Protozoan; D012337:RNA, Ribosomal, 18S
keywords: Babesia microti-like; non-human primate; simian-human immunodeficiency virus