title: [Impact of L-arginin immobilized on surgical suture material on the oxidation metabolism in the periwound tissues of the operated small bowel].
abstract: In experiment on 50 white rats of the Wistar line there was investigated the impact of L-arginin, while its systemic and local (in a content of synthetic absorbable suture material) application, on the indices of a free-radical and bioenergetics processes in a small bowel tissues after experimental enterotomy. There was shown, that as a consequence of L-arginin application there in periwound tissues of a small bowel on the third postoperative day the superoxidal anion-radical production and the processes of peroxidal oxidation of lipids (POL) go down, what prophylaxes the antioxidant potential lowering and a content of the macroergic complexes and energetic potential enhancement. The investigation results witness, that the L-arginin efficacy substantiates the need for creation of a new pharmacologically modified synthetic suture material, which prophylaxes the free-radical and hypoxic necrobiosis and stimulates healing processes in a surgical wound.
authors: T H
authors: TH
authors: Dikhtenko
authors: A A
authors: AA
authors: Levkov
authors: V O
authors: VO
authors: Kostenko
mesh_terms: D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001120:Arginine / Q000494:pharmacology*; D007421:Intestine, Small / Q000378:metabolism / Q000601:surgery*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013537:Sutures; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000227:Adenine Nucleotides; D000975:Antioxidants; D001120:Arginine