title: Near infrared light-triggered drug generation and release from gold nanoparticle carriers for photodynamic therapy.
abstract: A photoprecursor Pc 227 is covalently bound onto gold nanoparticles (Au NPs) to produce the known photodynamic therapy (PDT) drug Pc 4 upon 660 nm photoirradiation. The photochemical formation of the photoproduct Pc 4 is identified by spectroscopy, chromatography, and mass spectrometry and its PDT efficacy is equal to Pc 4 when administered non-covalently by Au NPs, with the added benefit of improved covalent delivery and targeted NIR-triggered release from the covalent Pc 227-Au NP conjugate, while during transport the attached Pc 227 is quenched by the Au NP and PDT inactivated.
authors: Department of Chemistry, Case Western Reserve University, Cleveland, Ohio.
authors: Yu
authors: Y
authors: Cheng
authors: Tennyson L
authors: TL
authors: Doane
authors: Chi-Hung
authors: CH
authors: Chuang
authors: Assem
authors: A
authors: Ziady
authors: Clemens
authors: C
authors: Burda
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D007259:Infrared Rays; D054833:Isoindoles; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D004364:Pharmaceutical Preparations; D010778:Photochemotherapy; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D004337:Drug Carriers; D007211:Indoles; D054833:Isoindoles; D004364:Pharmaceutical Preparations; D006046:Gold; C013647:phthalocyanine
keywords: caged drug; gold nanoparticle; photodynamic therapy; phototriggered release