title: Comparative endocrinology of leptin: assessing function in a phylogenetic context.
abstract: As we approach the end of two decades of leptin research, the comparative biology of leptin is just beginning. We now have several leptin orthologs described from nearly every major clade among vertebrates, and are moving beyond gene descriptions to functional studies. Even at this early stage, it is clear that non-mammals display clear functional similarities and differences with their better-studied mammalian counterparts. This review assesses what we know about leptin function in mammals and non-mammals, and gives examples of how these data can inform leptin biology in humans.
authors: Department of Biology and Program in Integrated Biosciences, University of Akron, Akron, OH, USA. Electronic address: londraville@uakron.edu.
authors: Richard L
authors: RL
authors: Londraville
authors: Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Mexico.
authors: Yazmin
authors: Y
authors: Macotela
authors: Department of Biology and Program in Integrated Biosciences, University of Akron, Akron, OH, USA.
authors: Robert J
authors: RJ
authors: Duff
authors: School of Biological Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.
authors: Marietta R
authors: MR
authors: Easterling
authors: Department of Biology and Program in Integrated Biosciences, University of Akron, Akron, OH, USA.
authors: Qin
authors: Q
authors: Liu
authors: School of Biological Sciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA.
authors: Erica J
authors: EJ
authors: Crespi
mesh_terms: D000818:Animals; D004704:Endocrinology / Q000639:trends*; D019143:Evolution, Molecular; D006801:Humans; D020738:Leptin / Q000235:genetics*; D010802:Phylogeny; D010828:Physiology, Comparative / Q000639:trends*; D014714:Vertebrates / Q000235:genetics*
chemical_list: D020738:Leptin
keywords: Amphibians; Fish; Immunology; Leptin; Phylogeny; Vertebrates