title: Role of adhesion molecules and proliferation hyperplasic, pre neoplastic and neoplastic lesions in canine prostate.
abstract: E-cadherin and beta-catenin are component of adherens junctions in epithelial cells. Loss of these proteins have been associated with progression of prostatic diseases. We performed immunohistochemistry for E-cadherin, beta-catenin and Ki-67 on canine prostatic lesions. We analyzed the expression of these antibodies in benign prostatic hyperplasia (BPH, n = 22), in pre neoplastic lesions Prostatic Intra-epithelial Neoplasia (PIN), n = 3 and Prostatic Inflammatory Atrophy (PIA), n = 7 and prostate carcinoma (PC, n = 10). In this study, a membranous expression of E-cadherin and beta-catenin and nuclear expression of Ki-67 antigen were demonstrated. The proliferative index was statistically different between carcinomas and BPH and carcinomas and pre-neoplastic lesions. Like in men, the reduction of E-cadherin and increase of Ki-67 expression in neoplastic lesions in dog prostate may be related to the carcinogenic process in this gland.
authors: São Paulo State University, Botucatu, Brazil.
authors: M M P
authors: MM
authors: Rodrigues
authors: Institute of Biomedical Sciences of Abel Salazar, University of Porto, Portugal.
authors: A
authors: A
authors: Rema
authors: Institute of Biomedical Sciences of Abel Salazar, University of Porto, Portugal.
authors: M F
authors: MF
authors: Gartner
authors: São Paulo State University, Botucatu, Brazil.
authors: R
authors: R
authors: Laufer-Amorim
mesh_terms: D000818:Animals; D001284:Atrophy / Q000378:metabolism / Q000473:pathology; D015820:Cadherins / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D004283:Dog Diseases / Q000378:metabolism* / Q000473:pathology; D004285:Dogs; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D011470:Prostatic Hyperplasia / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D019048:Prostatic Intraepithelial Neoplasia / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D051176:beta Catenin / Q000378:metabolism
chemical_list: D015820:Cadherins; D015815:Cell Adhesion Molecules; D019394:Ki-67 Antigen; D051176:beta Catenin