title: Detection of Amyloid β Signature in the Lens and Its Correlation in the Brain to Aid in the Diagnosis of Alzheimer's Disease.
abstract: We report the findings from a clinical trial in which a group of patients clinically diagnosed with probable Alzheimer's disease (AD) were discriminated from an age-matched group of healthy volunteers (HVs) with statistical significance (P<.001). The results from 20 patients with AD and 20 HVs were obtained by a Fluorescent Ligand Eye Scanning (FLES) technique that measures a fluorescent signature specific to an exogenous ligand bound to amyloid-β in the lens of the eye. Sensitivity and specificity of 85% and 95%, respectively, have been achieved in predicting clinical diagnosis. Additionally, amyloid brain imaging using florbetapir F18 positron emission tomography shows significant correlation with the results obtained in the eye. Results of the study demonstrate the safety of the FLES system.
authors: Cognoptix, Inc, Acton, MA, USA ckerbage@cognoptix.com.
authors: Charles
authors: C
authors: Kerbage
authors: Premiere Research Institute and Nova Southeastern University, West Palm Beach, FL, USA.
authors: Carl H
authors: CH
authors: Sadowsky
authors: Banner Alzheimer's Institute, Phoenix, AZ, USA.
authors: Pierre N
authors: PN
authors: Tariot
authors: Miami Jewish Health Systems, Miami, FL, USA.
authors: Marc
authors: M
authors: Agronin
authors: ATP Clinical Research Inc., Costa Mesa, CA, USA.
authors: Gustavo
authors: G
authors: Alva
authors: Cognoptix, Inc, Acton, MA, USA.
authors: F Darell
authors: FD
authors: Turner
authors: Cognoptix, Inc, Acton, MA, USA.
authors: Dennis
authors: D
authors: Nilan
authors: Cognoptix, Inc, Acton, MA, USA.
authors: Anne
authors: A
authors: Cameron
authors: Cognoptix, Inc, Acton, MA, USA.
authors: Gerald D
authors: GD
authors: Cagle
authors: Cognoptix, Inc, Acton, MA, USA.
authors: Paul D
authors: PD
authors: Hartung
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000814:Aniline Compounds; D001921:Brain / Q000000981:diagnostic imaging*; D005026:Ethylene Glycols; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D005026:Ethylene Glycols; D005462:Fluorine Radioisotopes; C545186:florbetapir
keywords: Alzheimer’s disease; amyloid PET imaging; amyloid-β; fluorescence spectroscopy; human lens