title: New insights into the role of Plg-RKT in macrophage recruitment.
abstract: Plasminogen (PLG) is the zymogen of plasmin, the major enzyme that degrades fibrin clots. In addition to its binding and activation on fibrin clots, PLG also specifically interacts with cell surfaces where it is more efficiently activated by PLG activators, compared with the reaction in solution. This results in association of the broad-spectrum proteolytic activity of plasmin with cell surfaces that functions to promote cell migration. Here, we review emerging data establishing a role for PLG, plasminogen receptors and the newly discovered plasminogen receptor, Plg-RKT, in macrophage recruitment in the inflammatory response, and we address mechanisms by which the interplay between PLG and its receptors regulates inflammation.
authors: Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA. Electronic address: lmiles@scripps.edu.
authors: Lindsey A
authors: LA
authors: Miles
authors: Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
authors: Shahrzad
authors: S
authors: Lighvani
authors: Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California, USA.
authors: Nagyung
authors: N
authors: Baik
authors: Department of Cell, Molecular and Developmental Biology, Yale University, New Haven, Connecticut, USA.
authors: Caitlin M
authors: CM
authors: Parmer
authors: Torrey Pines Institute for Molecular Studies, San Diego, California, USA.
authors: Sophia
authors: S
authors: Khaldoyanidi
authors: Torrey Pines Institute for Molecular Studies, San Diego, California, USA.
authors: Barbara M
authors: BM
authors: Mueller
authors: Department of Medicine, University of California San Diego, La Jolla, California, USA; Department of Medicine, Veterans Administration San Diego Healthcare System, San Diego, California, USA.
authors: Robert J
authors: RJ
authors: Parmer
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008264:Macrophages / Q000378:metabolism* / Q000473:pathology; D008969:Molecular Sequence Data; D010538:Peritonitis / Q000473:pathology; D010958:Plasminogen / Q000737:chemistry / Q000378:metabolism*; D040901:Proteomics; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface; D010958:Plasminogen
keywords: Macrophages; Monocytes; Plasminogen; Plasminogen receptors; Plg-R(KT); Thioglycollate; Tissue plasminogen activator; Urokinase