title: Integrating mitochondrial organization and dynamics with cellular architecture.
abstract: Mitochondrial organization, dynamics, and interactions with other intracellular structures and organelles are crucial for proper cell physiology. In this review we will discuss recent work on the significance of mitochondrial organization in regulating the size and distribution of mitochondrial DNA nucleoids and emphasize the importance of a new role for actin in regulating mitochondrial dynamics. We will also highlight new and unexpected examples of how mitochondria are integrated with many aspects of cell behavior, including cell migration, cell division, and the proper functioning of specialized cells such as neurons and immune cells. Together, these recent studies demonstrate the importance of mitochondrial organization in generating cellular architecture and vice versa.
authors: Department of Developmental and Cell Biology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA.
authors: Vaishali
authors: V
authors: Jayashankar
authors: Department of Developmental and Cell Biology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA. Electronic address: susanner@uci.edu.
authors: Susanne M
authors: SM
authors: Rafelski
mesh_terms: D000818:Animals; D001692:Biological Transport; D002455:Cell Division; D004272:DNA, Mitochondrial / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D006801:Humans; D042541:Intracellular Space / Q000737:chemistry / Q000378:metabolism; D008928:Mitochondria / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism
chemical_list: D004272:DNA, Mitochondrial