title: One-pot synthesis of coumarin-3-carboxamides containing a triazole ring via an isocyanide-based six-component reaction.
abstract: A facile, efficient, and environmentally friendly approach has been developed for the diversity oriented synthesis of trifunctional coumarin-amide-triazole containing compounds. A wide variety of pharmacologically significant and structurally interesting compounds were synthesized via a one-pot, six-component, tandem Knoevenagel/Ugi/click reaction sequence from readily available starting materials in ethanol at room temperature in excellent overall yields. Substituents could be independently varied at five different positions.
authors: Faculty of Chemistry, Shahid Beheshti University , G. C., P.O. Box 19396-4716, Tehran, Iran.
authors: Shabnam
authors: S
authors: Shaabani
authors: Ahmad
authors: A
authors: Shaabani
authors: Seik Weng
authors: SW
authors: Ng
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry*; D015394:Molecular Structure; D014230:Triazoles / Q000737:chemistry*
chemical_list: D003374:Coumarins; D003486:Cyanides; D014230:Triazoles