title: Cytotoxic prenylated xanthones from the pericarps of Garcinia mangostana.
abstract: Bioassay-guided fractionation of an ethanol extract of the pericarps of Garcinia mangostana led to the isolation of two new prenylated xanthones, named 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone (1) and 1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone (2), together with the five known compounds garcinones C (3) and D (4), gartanin (5), xanthone I (6), and γ-mangostin (7). Their structures were elucidated primarily based on MS and NMR data. Compounds 1-7 showed significant cytotoxic activities against various human cancer cell lines.
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. marinezengx@gmail.com.
authors: Zeng
authors: Z
authors: Xu
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. marinehuangl@gmail.com.
authors: Lei
authors: L
authors: Huang
authors: Instrumental Analysis and Research Center, Sun Yat-Sen University, Guangzhou 510275, China. chxiaoh@mail.sysu.edu.cn.
authors: Xiao-Hong
authors: XH
authors: Chen
authors: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China. zhuxfeng@mail.sysu.edu.cn.
authors: Xiao-Feng
authors: XF
authors: Zhu
authors: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China. marineqxj@gmail.com.
authors: Xiao-Jun
authors: XJ
authors: Qian
authors: State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China. marinefenggk@gmail.com.
authors: Gong-Kan
authors: GK
authors: Feng
authors: School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China. lanwj@mail.sysu.edu.cn.
authors: Wen-Jian
authors: WJ
authors: Lan
authors: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China. ceslhj@mail.sysu.edu.cn.
authors: Hou-Jin
authors: HJ
authors: Li
mesh_terms: D045744:Cell Line, Tumor / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D029762:Garcinia mangostana / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: C000591855:1,3,7-trihydroxy-2-(3-methyl-2-butenyl)-8-(3-hydroxy-3-methylbutyl)-xanthone; C000591857:1,3,8-trihydroxy-2-(3-methyl-2-butenyl)-4-(3-hydroxy-3-methylbutanoyl)-xanthone; D010936:Plant Extracts; D044004:Xanthones; C009689:xanthone