title: The role of S100B protein, neuron-specific enolase, and glial fibrillary acidic protein in the evaluation of hypoxic brain injury in acute carbon monoxide poisoning.
abstract: The main purpose of this study was to assess the role of S100B protein, neuron-specific enolase (NSE), and glial fibrillary acidic protein (GFAP) in the evaluation of hypoxic brain injury in acute carbon monoxide (CO)-poisoned patients. This cross-sectional study was conducted among the patients with acute CO poisoning who referred to the emergency department in a 1-year period. Serum levels of S100B protein, NSE, and GFAP were determined on admission. A total of 55 CO-poisoned patients (mean age ± standard deviation, 45 ± 20.3 years; 60% women) were included in the study. The control group consisted of 25 healthy adults. The patients were divided into two groups according to whether they were conscious or unconscious. The serum levels of S100B, NSE, and GFAP were higher in patients than that in the control group. There was no significant difference between unconscious and conscious patients with respect to these markers. There was a statistically significant difference between the conscious and unconscious patients and the control group in terms of S100B and NSE levels. There was also a statistically significant difference between the unconscious patients and the control group in terms of GFAP levels. Increased serum S100B, NSE, and GFAP levels are associated with acute CO poisoning. These biomarkers can be useful in assessing the clinical status of patients with CO poisoning.
authors: Faculty of Medicine, Department of Emergency Medicine, Ondokuz Mayis University, Samsun, Turkey hufukakdemir@hotmail.com.
authors: H U
authors: HU
authors: Akdemir
authors: Faculty of Medicine, Department of Emergency Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors: T
authors: T
authors: Yardan
authors: Faculty of Medicine, Department of Emergency Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors: C
authors: C
authors: Kati
authors: Faculty of Medicine, Department of Emergency Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors: L
authors: L
authors: Duran
authors: Department of Biochemistry, Ondokuz Mayis University, Samsun, Turkey.
authors: H
authors: H
authors: Alacam
authors: Faculty of Medicine, Department of Emergency Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors: Y
authors: Y
authors: Yavuz
authors: Department of Biochemistry, Ondokuz Mayis University, Samsun, Turkey.
authors: A
authors: A
authors: Okuyucu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000097:blood* / Q000453:epidemiology; D002249:Carbon Monoxide Poisoning / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000097:blood*; D006801:Humans; D000860:Hypoxia / Q000097:blood* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D011379:Prognosis; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D010751:Phosphopyruvate Hydratase
keywords: S100B protein; carbon monoxide poisoning; glial fibrillary acidic protein; hypoxic brain injury; neuron-specific enolase