title: The temporal lagged association between meteorological factors and malaria in 30 counties in south-west China: a multilevel distributed lag non-linear analysis.
abstract: BACKGROUND
  The association between malaria and meteorological factors is complex due to the lagged and non-linear pattern. Without fully considering these characteristics, existing studies usually concluded inconsistent findings. Investigating the lagged correlation pattern between malaria and climatic variables may improve the understanding of the association and generate possible better prediction models. This is especially beneficial to the south-west China, which is a high-incidence area in China.
  
  
  METHODS
  Thirty counties in south-west China were selected, and corresponding weekly malaria cases and four weekly meteorological variables were collected from 2004 to 2009. The Multilevel Distributed Lag Non-linear Model (MDLNM) was used to study the temporal lagged correlation between weekly malaria and weekly meteorological factors. The counties were divided into two groups, hot and cold weathers, in order to compare the difference under different climatic conditions and improve reliability and generalizability within similar climatic conditions.
  
  
  RESULTS
  Rainfall was associated with malaria cases in both hot and cold weather counties with a lagged correlation, and the lag range was relatively longer than those of other meteorological factors. Besides, the lag range was longer in hot weather counties compared to cold weather counties. Relative humidity was correlated with malaria cases at early and late lags in hot weather counties.Minimum temperature had a longer lag range and larger correlation coefficients for hot weather counties compared to cold weather counties. Maximum temperature was only associated with malaria cases at early lags.
  
  
  CONCLUSIONS
  Using weekly malaria cases and meteorological information, this work studied the temporal lagged association pattern between malaria cases and meteorological information in south-west China. The results suggest that different meteorological factors show distinct patterns and magnitudes for the lagged correlation, and the patterns will depend on the climatic condition. Existing inconsistent findings for climatic factors' lags could be due to either the invalid assumption of a single fixed lag or the distinct temperature conditions from different study sites. The lag pattern for meteorological factors should be considered in the development of malaria early warning system.
authors: Xing
authors: X
authors: Zhao
authors: Fei
authors: F
authors: Chen
authors: Zijian
authors: Z
authors: Feng
authors: West China School of Public Health, Sichuan University, No,17 Section 3, South Renmin Road, 610041 Chengdu, China. lixiaosong1101@126.com.
authors: Xiaosong
authors: X
authors: Li
authors: Xiao-Hua
authors: XH
authors: Zhou
mesh_terms: D002681:China / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008288:Malaria / Q000453:epidemiology*; D008685:Meteorological Concepts; D013997:Time Factors