title: Tamarind seed polysaccharide-gellan mucoadhesive beads for controlled release of metformin HCl.
abstract: The paper describes the development, optimization and evaluation of tamarind seed polysaccharide (TSP)-blended gellan gum (GG) mucoadhesive beads containing metformin HCl through Ca(2+)-ion cross-linked ionic gelation for oral drug delivery. Effects of GG to TSP ratio and cross-linker (CaCl2) concentration on the drug encapsulation efficiency (DEE, %), and cumulative drug release after 10h (R10h, %) of TSP-GG mucoadhesive beads containing metformin HCl were optimized by 32 factorial design. The optimized mucoadhesive beads (F-O) showed DEE of 95.73 ± 4.02%, R10h of 61.22 ± 3.44% and mean diameter of 1.70 ± 0.24 mm.These beads were characterized by SEM and FTIR analyses. The in vitro drug release from these beads showed controlled-release (zero-order) pattern over a period of 10h.The optimized TSP-GG mucoadhesive beads also exhibited pH-dependent swelling, good mucoadhesivity with biological mucosal membrane and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.
authors: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Jharpokharia 757086, Odisha, India.
authors: Amit Kumar
authors: AK
authors: Nayak
authors: Department of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur 495009, Chhattisgarh, India. Electronic address: drdilip71@gmail.com.
authors: Dilipkumar
authors: D
authors: Pal
authors: Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj, Jharpokharia 757086, Odisha, India.
authors: Kousik
authors: K
authors: Santra
mesh_terms: D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000737:chemistry*; D008687:Metformin / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D029861:Tamarindus / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D007004:Hypoglycemic Agents; D011134:Polysaccharides; D011135:Polysaccharides, Bacterial; D000496:Alloxan; C048288:gellan gum; D008687:Metformin
keywords: Controlled drug release; Gellan gum; Metformin HCl; Mucoadhesion; Polymer-blend; Tamarind seed polysaccharide