title: Baroreflex activation therapy in patients with pre-existing implantable cardioverter-defibrillator: compatible, complementary therapies.
abstract: OBJECTIVE
  The Neo™ System (CVRx) is an implantable device, CE certified for the treatment of resistant hypertension and investigationally used to treat systolic heart failure by electrical stimulation of the carotid baroreceptors. It is unknown whether interaction might exist between the Neo System and implantable cardioverter-defibrillators (ICDs).
  
  
  RESULTS
  Compatibility of the Neo device was tested in seven consecutive patients with pre-existing ICDs. Intra- and post-operative testing was completed with ICD and Neo settings programmed to provoke interaction. Intracardiac electrograms were printed to determine interaction with the ICD. Interaction testing during implantation and follow-up showed that there was no device-device interaction. No interaction was observed at maximum atrial and ventricular sensitivity settings and maximum Neo output settings.
  
  
  CONCLUSIONS
  Combined therapy with the Neo device and at least in this study reported that transvenous ICD systems can be performed safely.
authors: Department of Cardiothoracic Surgery, Cologne University Heart Centre, Kerpener Strasse 62, 50937 Cologne, Germany navid.madershahian@uk-koeln.de.
authors: Navid
authors: N
authors: Madershahian
authors: Department of Cardiothoracic Surgery, Cologne University Heart Centre, Kerpener Strasse 62, 50937 Cologne, Germany.
authors: Maximilian
authors: M
authors: Scherner
authors: Department of Internal Medicine III, University of Cologne, 50937 Cologne, Germany.
authors: Jochen
authors: J
authors: Müller-Ehmsen
authors: Department of Internal Medicine III, University of Cologne, 50937 Cologne, Germany.
authors: Marcel
authors: M
authors: Halbach
authors: Department of Internal Medicine III, University of Cologne, 50937 Cologne, Germany.
authors: Tilman
authors: T
authors: Hickethier
authors: CVRx. Inc., 9201 West Broadway Avenue, Minneapolis, MN 55445, USA.
authors: Ralf
authors: R
authors: Velden
authors: Department of Cardiothoracic Surgery, Cologne University Heart Centre, Kerpener Strasse 62, 50937 Cologne, Germany.
authors: Yeong-Hoon
authors: YH
authors: Choi
authors: Department of Cardiothoracic Surgery, Cologne University Heart Centre, Kerpener Strasse 62, 50937 Cologne, Germany.
authors: Jens
authors: J
authors: Wippermann
authors: Department of Cardiothoracic Surgery, Cologne University Heart Centre, Kerpener Strasse 62, 50937 Cologne, Germany.
authors: Thorsten
authors: T
authors: Wahlers
mesh_terms: D000328:Adult; D000368:Aged; D017704:Baroreflex / Q000528:radiation effects*; D003131:Combined Modality Therapy / Q000295:instrumentation / Q000379:methods; D017147:Defibrillators, Implantable; D004599:Electric Stimulation Therapy / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000517:prevention & control*; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D013813:Therapy, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D016896:Treatment Outcome
keywords: Carotid baroreceptor; Heart failure; Implantable cardioverter-defibrillator; Resistant hypertension