title: Mechanisms of systemic wound response in Drosophila.
abstract: In response to cellular and tissue losses caused by physical or chemical injuries, organisms must activate multiple wound repair systems at the cellular, tissue, and organismal levels. The systemic wound response (SWR) that occurs via interorgan communication between local wound sites and remote organs ensures that the host is protected efficiently in response to a local wound. The local wound response around the wound site is fairly well documented, but the molecular mechanisms that allow the host to launch SWR are poorly understood. Recent studies on the Drosophila adult model system have shown that the local wound response is not restricted to the wound site because it plays an essential role in generating signals transmitted to remote organs that subsequently achieve SWR. By exploiting the genetic methods available for investigating Drosophila, we are just beginning to understand the complex interorgan networks that operate during SWRs. This review discusses the basic processes involved with classical integumental wound responses and tissue regeneration, such as epithelial cell movement, hemocyte recruitment, apoptosis, melanization, and generation of reactive oxygen species, as well as the recently described intestinal epithelial cell renewal program that occurs in response to gut cell damages. Furthermore, we discuss how these local wound responses integrate with organ-to-organ communication to launch SWR. Genetic analysis of SWRs using the Drosophila model system will provide a unique opportunity to dissect the molecular mechanisms that control wound-induced organ-to-organ communication.
authors: School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul, South Korea. Electronic address: lwj@snu.ac.kr.
authors: Won-Jae
authors: WJ
authors: Lee
authors: Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, and Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Tokyo, Japan. Electronic address: miura@mol.f.u-tokyo.ac.jp.
authors: Masayuki
authors: M
authors: Miura
mesh_terms: D000483:Alleles; D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D049109:Cell Proliferation; D004330:Drosophila; D004847:Epithelial Cells / Q000166:cytology; D006434:Hemocytes / Q000166:cytology; D006801:Humans; D007422:Intestines / Q000166:cytology; D017382:Reactive Oxygen Species / Q000378:metabolism; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology; D014945:Wound Healing
chemical_list: D017382:Reactive Oxygen Species; D020169:Caspases
keywords: Caspase; Drosophila; Epithelial cell renewal; Integumental wound; Interorgan communication; Intestinal stem cells; Phenoloxidase; Reactive oxygen species; Systemic wound response; Wound healing