title: Concurrent posterior semicircular canal benign paroxysmal positional vertigo in patients with ipsilateral sudden sensorineural hearing loss: is it caused by otolith particles?
abstract: The etiology of benign paroxysmal positional vertigo (BPPV) is still elusive even though detached otolith particles from the utricular macula are generally thought to be responsible for the pathogenesis of BPPV. Sudden sensorineural hearing loss (SSNHL), of which the etiology is also idiopathic in most cases, may accompany concurrent BPPV. This uncommon condition of concurrent BPPV with SSNHL has been assumptively explained as selective damage of the cochlea and the utricle due to viral neurolabyrinthitis. Recently, radiological evidences that inner ear hemorrhage is observed in patients with SSNHL accompanied by severe vertigo have been reported. The basic hypothesis for this study is that blood debris in the endolymphatic fluid due to inner ear hemorrhage is one of the causes of concurrent posterior semicircular canal (PSCC) BPPV in patient with ipsilateral SSNHL. In this report, we will outline the clinical findings of 4 patients with PSCC BPPV with SSNHL, and present an experimental results using whole blood in artificial endolymph to evaluate the hypothesis.
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Republic of Korea.
authors: Chang-Hee
authors: CH
authors: Kim
authors: Department of Otorhinolaryngology-Head and Neck Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Republic of Korea.
authors: Jung Eun
authors: JE
authors: Shin
authors: Asan Medical Center, Ulsan University College of Medicine, Republic of Korea.
authors: Hong Ju
authors: HJ
authors: Park
authors: Seoul National University Bundang Hospital, Seoul National University College of Medicine, Republic of Korea.
authors: Ja-Won
authors: JW
authors: Koo
authors: Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: junlee@snu.ac.kr.
authors: Jun Ho
authors: JH
authors: Lee
mesh_terms: D000368:Aged; D065635:Benign Paroxysmal Positional Vertigo; D007758:Ear, Inner / Q000503:physiopathology; D004710:Endolymph; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D010037:Otolithic Membrane / Q000503:physiopathology; D012665:Semicircular Canals / Q000503:physiopathology; D014717:Vertigo / Q000150:complications / Q000175:diagnosis*