title: Progression to impaired glucose tolerance or type 2 diabetes mellitus in polycystic ovary syndrome: a controlled follow-up study.
abstract: OBJECTIVE
  To investigate whether retesting with the oral glucose tolerance test (OGTT) is useful and necessary for all women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Follow-up study.
  
  
  METHODS
  Tertiary medical center.
  
  
  METHODS
  Eighty-four women with PCOS and 45 healthy controls.
  
  
  METHODS
  Peripheral venous blood sampling.
  
  
  METHODS
  We performed a 75-g 2-hour OGTT in women with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT) at the time of the first test with and without PCOS.
  
  
  RESULTS
  The average follow-up period for women with PCOS was 2.6 years (range, 2-4.17 years). Seventy-eight of these women had NGT at baseline, 11.5% converted to IGT, with an annualized incidence rate of 4.5%. Of those women with IGT at baseline (n = 6), 33.3% converted to type 2 diabetes mellitus, with an annualized incidence rate of 10.4%. In the healthy subjects, the average follow-up period was 2.6 years (range, 2-4.08 years). Forty-two of these women had NGT at baseline, 2.3% converted to IGT, giving a progression of 0.9% per year. Among the three women with IGT at baseline, 33.3% reverted to NGT, and 66.6% had persistent IGT.
  
  
  CONCLUSIONS
  Conversion rates from NGT to IGT or type 2 diabetes mellitus were accelerated in women with PCOS compared with healthy subjects. Women with PCOS should be tested regularly for early detection of abnormal glucose tolerance. In addition, the interval for periodic rescreening should be determined by further studies involving more women with PCOS.
authors: Department of Gynecology and Obstetrics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey. Electronic address: cemcel@yahoo.com.
authors: Cem
authors: C
authors: Celik
authors: Department of Gynecology and Obstetrics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
authors: Nicel
authors: N
authors: Tasdemir
authors: Department of Gynecology and Obstetrics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
authors: Remzi
authors: R
authors: Abali
authors: Department of Gynecology and Obstetrics, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors: Ercan
authors: E
authors: Bastu
authors: Department of Endocrinology and Metabolism, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
authors: Murat
authors: M
authors: Yilmaz
mesh_terms: D000328:Adult; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D005951:Glucose Tolerance Test / Q000706:statistics & numerical data*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
keywords: Follow-up; diabetes mellitus; impaired glucose tolerance; polycystic ovary syndrome