title: Single particle detection in CMOS compatible photonic crystal nanobeam cavities.
abstract: We report the label-free detection of single particles using photonic crystal nanobeam cavities fabricated in silicon-on-insulator platform, and embedded inside microfluidic channels fabricated in poly-dimethylsiloxane (PDMS). Our system operates in the telecommunication wavelength band, thus leveraging the widely available, robust and tunable telecom laser sources. Using this approach, we demonstrated the detection of polystyrene nanoparticles with dimensions down to 12.5nm in radius. Furthermore, binding events of a single streptavidin molecule have been observed.
authors: Qimin
authors: Q
authors: Quan
authors: Daniel L
authors: DL
authors: Floyd
authors: Ian B
authors: IB
authors: Burgess
authors: Parag B
authors: PB
authors: Deotare
authors: Ian W
authors: IW
authors: Frank
authors: Sindy K Y
authors: SK
authors: Tang
authors: Rob
authors: R
authors: Ilic
authors: Marko
authors: M
authors: Loncar
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D057054:Molecular Imaging / Q000295:instrumentation*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D012666:Semiconductors; D020349:Surface Plasmon Resonance / Q000295:instrumentation*