title: Evaluation of the antibacterial potential of Petroselinum crispum and Rosmarinus officinalis against bacteria that cause urinary tract infections.
abstract: In this study we evaluated the antibacterial activity of the crude hydroalcoholic extracts, fractions, and compounds of two plant species, namely Rosmarinus officinalis and Petroselinum crispum, against the bacteria that cause urinary tract infection. The microdilution method was used for determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). The crude hydroalcoholic extract of R. officinalis displayed in vitro activity against Gram-positive bacteria, with satisfactory MBC for the clinical isolate S. saprophyticus. The fractions and the pure compound rosmarinic acid did not furnish promising results for Gram-negative bacteria, whereas fractions 2, 3, and 4 gave encouraging results for Gram-positive bacteria and acted as bactericide against S. epidermidis as well as E. faecalis (ATCC 29212) and its clinical isolate. R. officinalis led to promising results in the case of Gram-positive bacteria, resulting in a considerable interest in the development of reliable alternatives for the treatment of urinary infections.
authors: Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Laboratório de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Franca, SP, Brazil.
authors: Fernanda Villas Boas
authors: FV
authors: Petrolini
authors: Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Laboratório de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Franca, SP, Brazil.
authors: Rodrigo
authors: R
authors: Lucarini
authors: Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Laboratório de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Franca, SP, Brazil.
authors: Maria Gorete Mendes
authors: MG
authors: de Souza
authors: Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Laboratório de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Franca, SP, Brazil.
authors: Regina Helena
authors: RH
authors: Pires
authors: Núcleo de Pesquisa em Ciências Exatas e Tecnológica, Grupo de Pesquisa em Produtos Naturais, Universidade de Franca, Franca, SP, Brazil.
authors: Wilson Roberto
authors: WR
authors: Cunha
authors: Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Laboratório de Pesquisa em Microbiologia Aplicada, Universidade de Franca, Franca, SP, Brazil.
authors: Carlos Henrique Gomes
authors: CH
authors: Martins
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D028528:Petroselinum / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D027542:Rosmarinus / Q000737:chemistry*; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts
keywords: Petroselinum crispum; Rosmarinus officinalis; Urinary Tract Infections (UTI); antibacterial activity; bioassay