title: Getting CAD in shape: the atomic structure of human dihydroorotase domain.
abstract: CAD is a large multifunctional polypeptide that initiates and controls the de novo biosynthesis of pyrimidines in animals. In this issue of Structure, Grande-García and colleagues provide the first atomic information of this antitumoral target by reporting the crystal structure of the dihydroorotase domain of human CAD.
authors: Department of Crystallography and Structural Biology, Instituto Química-Física "Rocasolano," CSIC, Serrano 119, 28006 Madrid, Spain. Electronic address: xjuan@iqfr.csic.es.
authors: Juan A
authors: JA
authors: Hermoso
mesh_terms: D001221:Aspartate Carbamoyltransferase / Q000737:chemistry*; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000737:chemistry*; D004080:Dihydroorotase / Q000737:chemistry*; D006801:Humans
chemical_list: C033626:CAD trifunctional enzyme; D001221:Aspartate Carbamoyltransferase; D004080:Dihydroorotase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)