title: The effect of dexmedetomidine on oxidative stress during pneumoperitoneum.
abstract: OBJECTIVE
  This study was intended to investigate the effect of dexmedetomidine on oxidative stress response in pneumoperitoneum established in rats.
  
  
  METHODS
  Animals were randomized into three groups, group S: with no pneumoperitoneum, group P: with pneumoperitoneum established, and group D: given 100 mcg intraperitoneal dexmedetomidine 30 min before establishment of pneumoperitoneum. Plasma total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) activity were measured 30 min after conclusion of pneumoperitoneum.
  
  
  RESULTS
  The mean TOS level was significantly higher in group P than in the other two groups, and the TOS level was significantly higher in group D than in group S (P < 0.05). Plasma TAS level was found to be lower in group P than in the other two groups, and the TAS level was lower in group D than in group S (P < 0.05). Consequently, the OSI was significantly higher in group P than in groups D and S (P < 0.05).
  
  
  CONCLUSIONS
  Ischemia-reperfusion phenomenon that occurs during pneumoperitoneum causes oxidative stress and consumption of plasma antioxidants. Dexmedetomidine decreases oxidative stress caused by pneumoperitoneum and strengthens the antioxidant defense system.
authors: Department of Anesthesiology and Critical Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Bahanur
authors: B
authors: Cekic
authors: Department of Anesthesiology and Critical Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Sukran
authors: S
authors: Geze
authors: Department of Nephrology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Gulsum
authors: G
authors: Ozkan
authors: Department of Anesthesiology and Critical Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Ahmet
authors: A
authors: Besir
authors: Department of Hematology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Mehmet
authors: M
authors: Sonmez
authors: Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: S Caner
authors: SC
authors: Karahan
authors: Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Ahmet
authors: A
authors: Mentese
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis; D020927:Dexmedetomidine / Q000494:pharmacology*; D005260:Female; D018384:Oxidative Stress / Q000187:drug effects*; D011027:Pneumoperitoneum / Q000378:metabolism*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D020927:Dexmedetomidine