title: Pulmonary hypertension in a pregnant patient with thyrotoxicosis due to Graves' disease: considerations with respect to treatment.
abstract: A 13 weeks pregnant 24-year-old patient with a history of Graves' disease presented with progressive dyspnoea existing for 4-6 weeks. Blood tests showed severe thyrotoxicosis and transthoracic echocardiography suggested severe pulmonary hypertension (PH) which was thought to be secondary to thyrotoxicosis. PH secondary to thyrotoxicosis is often reversible and may occur 3-14 months after normalisation of free T4 and T3 levels. The maternal mortality risk of PH in pregnancy is high despite modern treatment strategies (17-33%). In this case, PH was carefully monitored for 1 month. No changes in pulmonary artery pressure were found despite immediate treatment with propylthiouracil and β-blockade. We anticipated that the normalisation of pulmonary artery pressure would not occur during this pregnancy and that the risk of complications would remain high. In the interest of the mother an abortion was suggested. Termination of pregnancy took place at the gestational age of 16 weeks.
authors: Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
authors: Vanja
authors: V
authors: Mathot
authors: Erik
authors: E
authors: Oosterwerff
authors: Mariëlle G
authors: MG
authors: van Pampus
authors: Robert
authors: R
authors: Riezebos
mesh_terms: D000032:Abortion, Therapeutic; D005260:Female; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000209:etiology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000209:etiology*; D013971:Thyrotoxicosis / Q000209:etiology*; D055815:Young Adult