title: Point prevalence and risk factors for food allergy in a cohort of 386 children with atopic dermatitis attending a multidisciplinary dermatology/paediatric allergy clinic.
abstract: BACKGROUND
  There is considerable debate about the prevalence and relevance of food allergy (FA) in atopic dermatitis (AD). The aim of this study was to investigate the prevalence of and risk factors for FA in a cohort of children with AD attending a multidisciplinary paediatric allergy clinic.
  
  
  METHODS
  The analysis was performed on 386 children (50.8% boys, median age 4 years) consecutively evaluated for AD. A diagnosis of FA was established on positive skin tests and/or a specific IgE value or a positive oral food challenge.
  
  
  RESULTS
  Point prevalence of FA was 17.8%. Egg, peanuts, milk, tree nut and mustard accounted for 93% of cases. 37.7% of children had ≥2 positive food reactions. Risk factors associated with FA were young age (OR=7.9 when ≤2 years compared with ≥5 years), moderate to severe AD (OR=7.8 for severe and 2.4 for moderate AD) and onset of AD before 3 months of age (OR=5.7).
  
  
  CONCLUSIONS
  Point prevalence of FA in children with AD is lower than initially reported in patients recruited in a paediatric allergology setting. Children≤2 years of age with early-onset or severe AD are at higher risk of FA and may be candidates for FA evaluation.
authors: Paul Sabatier University and Dermatology Department, Larrey Hospital, 24 Chemin de Pouvourville, 30030 Toulouse, France.
authors: Claire
authors: C
authors: Mailhol
authors: Paul Sabatier University and Dermatology Department, Larrey Hospital, 24 Chemin de Pouvourville, 30030 Toulouse, France.
authors: Françoise
authors: F
authors: Giordano-Labadie
authors: Epidemiology Department, Paul Sabatier University, Toulouse, France.
authors: Valérie
authors: V
authors: Lauwers-Cances
authors: Paul Sabatier University and Dermatology Department, Larrey Hospital, 24 Chemin de Pouvourville, 30030 Toulouse, France.
authors: Alfred
authors: A
authors: Ammoury
authors: Paul Sabatier University and Dermatology Department, Larrey Hospital, 24 Chemin de Pouvourville, 30030 Toulouse, France.
authors: Carle
authors: C
authors: Paul
authors: Pneumology and Allergology Department, Children Hospital, Toulouse, France.
authors: Fabienne
authors: F
authors: Rance
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003663:Decision Trees; D003876:Dermatitis, Atopic / Q000150:complications*; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D012307:Risk Factors
keywords: atopic dermatitis; children; food allergy; prevalence; risk factors