title: Evaluation of serum endothelial cell specific molecule-1 (endocan) levels as a biomarker in patients with pulmonary thromboembolism.
abstract: The aim of this study was to investigate the relationship between pulmonary thromboembolism (PTE) and serum endocan levels. The study included 46 patients with a diagnosis of PTE and control group (25 healthy individuals). Serum endocan levels in all participants' blood samples were measured. The average age of the individuals was 61.76 ± 16.39 years. There was a significant difference in the serum endocan levels between the patients and those of the control group [321.93 ng/l (111.35-2511.33) and 192.77 ng/l (118.30-309.02), respectively; P < 0.030]. The serum endocan levels in the submassive [469.41 ng/l (258.13-800.54)] and the massive PTE groups [719.18 ng/l (319.84-2511.33)] were statistically higher than those in the control group [192.77 ng/l (118.30-309.02)] (P < 0.001 and P < 0.001, respectively). In addition, there was a statistically significant difference between the serum endocan levels of the nonmassive PTE group [188.57 ng/l (111.35-685.56)] and the submassive PTE group (P < 0.01). The serum endocan levels correlated with the international normalization ratio (INR), right ventricular dilatation (RVD) and SBP (r = 0.418, P = 0.004; r = 0.659, P < 0.001; r = -0.425, P = 0.003, respectively). In conclusion, serum endocan levels can be considered a practicable biomarker to determine the severity of PTEs and follow-up thrombolytic therapy.
authors: aDepartment of Chest Disease bDepartment of Emergency, Faculty of Medicine cDepartment of Pedodontics, Faculty of Dentistry dDepartment of Medical Biochemistry, Faculty of Medicine eDepartment of Industrial Engineering, Faculty of Engineering, Ondokuz Mayıs University, Samsun, Turkey.
authors: Aygül
authors: A
authors: Güzel
authors: Latif
authors: L
authors: Duran
authors: Nurhan
authors: N
authors: Köksal
authors: Aysun Cağlar
authors: AC
authors: Torun
authors: Hasan
authors: H
authors: Alaçam
authors: Birsen Cirit
authors: BC
authors: Ekiz
authors: Naci
authors: N
authors: Murat
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D011379:Prognosis; D011509:Proteoglycans / Q000097:blood*; D011655:Pulmonary Embolism / Q000097:blood* / Q000175:diagnosis; D012307:Risk Factors
chemical_list: D015415:Biomarkers; C101134:ESM1 protein, human; D009363:Neoplasm Proteins; D011509:Proteoglycans