title: 2-Amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles as New Cytotoxic Agents.
abstract: A series of 2-amino-4-(nitroalkyl)-4H-chromene-3-carbonitriles were synthesized by an efficient multicomponent reaction in aqueous media using DBU as a catalyst at room temperature. Mild condition, environment friendly procedure and excellent yields are the main advantages of this procedure. The cytotoxic activity of target compounds were evaluated against three cancer cell lines MDA-MB-231, MCF-7 and T47D in comparison with etoposide as reference drug. Generally, all compounds showed good cell growth inhibitory activity with IC(50) values less than 30 μg/mL. Their activities were comparable or more potent than standard drug etoposide. The 6-bromo- derivatives 7e and 7f showed promising cytotoxic activity with IC50 values in the range of 3.46-18.76 μg/mL, being more potent than etoposide against all tested cell lines.
authors: School of Chemistry, University College of Science, University of Tehran, P.O. Box 14155- 6455, Tehran, Iran.
authors: Afsaneh
authors: A
authors: Zonouzi
authors: School of Chemistry, University College of Science, University of Tehran, P.O. Box 14155- 6455, Tehran, Iran.
authors: Roghieh
authors: R
authors: Mirzazadeh
authors: Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Maliheh
authors: M
authors: Safavi
authors: Institute of Biochemistry and Biophysics, Department of Biochemistry, University of Tehran, Tehran, Iran.
authors: Sussan
authors: S
authors: Kabudanian Ardestani
authors: Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors: Saeed
authors: S
authors: Emami
authors: Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. ; Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors: Alireza
authors: A
authors: Foroumadi
keywords: 4H-chromenes; Benzopyran; Cytotoxic activity; DBU; One-pot synthesis