title: Preventive effect of Zea mays L. (purple waxy corn) on experimental diabetic cataract.
abstract: Recently, substances possessing antioxidant can prevent cataractogenesis of diabetic cataract. Therefore, this study was carried out to determine the anticataract effect of Zea mays L. (purple waxy corn), a flavonoids rich plant, in experimental diabetic cataract. Enucleated rat lenses were incubated in artificial aqueous humor containing 55 mM glucose with various concentrations of Zea mays L. (purple waxy corn) ranging between 2, 10, and 50 mg/mL at room temperature for 72 h. At the end of the incubation period, the evaluation of lens opacification, MDA level, and the activities of SOD, CAT, GPx, and AR in lens were performed. The results showed that both medium and high doses of extract decreased lens opacity together with the decreased MDA level. In addition, medium dose of extract increased GPx activity while the high dose decreased AR activity. No other significant changes were observed. The purple waxy corn seeds extract is the potential candidate to protect against diabetic cataract. The mechanism of action may occur via the decreased oxidative stress and the suppression of AR. However, further research in vivo is still essential.
authors: Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand ; Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Paphaphat
authors: P
authors: Thiraphatthanavong
authors: Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand ; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Jintanaporn
authors: J
authors: Wattanathorn
authors: Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand ; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Supaporn
authors: S
authors: Muchimapura
authors: Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand ; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Thukham-mee
authors: TM
authors: Wipawee
authors: Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand ; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Panakaporn
authors: P
authors: Wannanon
authors: Integrative Complementary Alternative Medicine Research and Development Center, Khon Kaen University, Khon Kaen 40002, Thailand ; Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Tong-un
authors: TU
authors: Terdthai
authors: Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Bhalang
authors: B
authors: Suriharn
authors: Faculty of Agriculture, Khon Kaen University, Khon Kaen 40002, Thailand.
authors: Kamol
authors: K
authors: Lertrat
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001082:Aqueous Humor / Q000187:drug effects; D002386:Cataract / Q000188:drug therapy* / Q000473:pathology; D048909:Diabetes Complications / Q000188:drug therapy* / Q000503:physiopathology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D003313:Zea mays / Q000737:chemistry
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D005947:Glucose