title: Targeted therapy in gliomas.
abstract: The survival outcome of patients with malignant gliomas is still poor, despite advances in surgical techniques, radiation therapy and the development of novel chemotherapeutic agents. The heterogeneity of molecular alterations in signaling pathways involved in the pathogenesis of these tumors contributes significantly to their resistance to treatment. Several molecular targets for therapy have been discovered over the last several years. Therapeutic agents targeting these signaling pathways may provide more effective treatments and may improve survival. This review summarizes the important molecular therapeutic targets and the outcome of published clinical trials involving targeted therapeutic agents in glioma patients.
authors: The University of Texas MD Anderson Cancer Center, Houston, TX, USA, m_hamza67@hotmail.com.
authors: Mohamed Ali
authors: MA
authors: Hamza
authors: Mark
authors: M
authors: Gilbert
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016543:Central Nervous System Neoplasms / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*
chemical_list: D000970:Antineoplastic Agents