title: [Expressions of Cx26, Cx32 and Cx43 in prostate cancer and their implications].
abstract: OBJECTIVE
  To investigate the expressions of Cx26, Cx32 and Cx43 in prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and their roles in the development and progression of PCa in order to provide some novel evidence for the diagnosis and treatment of PCa.
  
  
  METHODS
  We determined the expressions of Cx26, Cx32 and Cx43 in the paraffin samples from 31 cases of PCa and 23 cases of BPH by SABC immunohistochemical staining, and analyzed the relationship of their expressions with the clinical and pathological parameters of PCa and BPH using the semiquantitative method.
  
  
  RESULTS
  The positive expressions of Cx26 in BPH and PCa were 82.6% and 74.2%, respectively (chi2 = 0.541, P > 0.05), those of Cx32 were 78.3% and 61.3% (chi2 = 1.763, P > 0.05), and those of Cx43 were 87.0% and 38.7% (chi2 = 12.730, P < 0.01). The staining intensities of Cx26 and Cx43 were negatively correlated with the malignant phenotype of PCa (rCx26 = -0.476, P < 0.01; rCx43 = -0.484, P < 0.01), but not the expression of Cx32 (r = -0.242, P > 0.05). The three Cxs exhibited no correlation with the age and serum PSA level of the patients (P > 0.05), nor among their expressions (P > 0.05).
  
  
  CONCLUSIONS
  Cx26, Cx32 and Cx43 are expressed in different degrees in BPH and PCa tissues. Cx43 plays a role in the occurrence and progression of PCa, and may serve as a new marker of PCa besides PSA as well as a new target in the biotherapy of PCa. Cx26 may be partially involved in the progression of PCa, but its mechanisms need to be further studied.
authors: Department of Urology, Haikou People's Hospital/Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou, Hainan 570208, China. hkyyhlp@163.com
authors: Li-Ping
authors: LP
authors: Hu
authors: Department of Urology, Haikou People's Hospital/Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou, Hainan 570208, China.
authors: Zhen-Xiang
authors: ZX
authors: Liu
authors: Department of Urology, Haikou People's Hospital/Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou, Hainan 570208, China.
authors: Zhi-Ming
authors: ZM
authors: Bai
authors: Department of Urology, Haikou People's Hospital/Haikou Hospital Affiliated to Xiangya School of Medicine, Central South University, Haikou, Hainan 570208, China.
authors: Shun
authors: S
authors: Tan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000072259:Connexin 26; D018031:Connexin 43 / Q000378:metabolism*; D017630:Connexins / Q000378:metabolism*; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D000097002:Gap Junction beta-1 Protein
chemical_list: D000072259:Connexin 26; D018031:Connexin 43; D017630:Connexins; D000097002:Gap Junction beta-1 Protein; C000607042:GJB2 protein, human