title: A mouse model of chronic cerebral hypoperfusion characterizing features of vascular cognitive impairment.
abstract: Vascular dementia or vascular cognitive impairment occurs as a result of persistently compromised blood flow to the brain and represents the second most common type of dementia after Alzheimer's disease. In order to investigate its underlying mechanisms, a mouse model of chronic cerebral hypoperfusion has been developed, which involves the narrowing of the bilateral common carotid arteries with newly designed microcoils. This mouse model provides a unique platform to investigate the mechanisms of angiogenesis following chronic cerebral hypoperfusion and to explore potential drugs or cell therapies designed to enhance angiogenesis as a preclinical step toward developing novel treatments for dementia of vascular origin.
authors: Department of Stroke and Cerebrovascular Diseases, National Cerebral and Cardiovascular Center, Osaka, Japan.
authors: Masafumi
authors: M
authors: Ihara
authors: Akihiko
authors: A
authors: Taguchi
authors: Takakuni
authors: T
authors: Maki
authors: Kazuo
authors: K
authors: Washida
authors: Hidekazu
authors: H
authors: Tomimoto
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply; D003072:Cognition Disorders / Q000209:etiology*; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000523:psychology*; D051379:Mice; D008810:Mice, Inbred C57BL; D020768:Middle Cerebral Artery / Q000473:pathology