title: Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment.
abstract: Mild cognitive impairment (MCI) is regarded as a prodromal phase of late onset Alzheimer's disease (LOAD). It has been proposed that oxidative stress (OxS) might be implicated in the pathogenesis of LOAD. The aim of this study was to investigate whether a redox imbalance measured as serum level of hydroperoxides (i.e., by-products of lipid peroxidation) and/or serum antioxidant capacity might be predictive of the clinical progression of MCI to LOAD. The levels of these two markers were measured in 111 patients with MCI (follow-up: 2.0 ± 0.6 years), 105 patients with LOAD, and 118 nondemented healthy controls. Multivariate analysis adjusted for potential confounding factors, including age, gender, smoking, and comorbidities, showed a significant increase (P < 0.05) in baseline levels of OxS in MCI and LOAD as compared to cognitive healthy controls. No differences in either of OxS markers were found by comparing MCI patients who converted (n = 29) or not converted (n = 82) to LOAD. Overall, these results suggest that systemic OxS might be a precocious feature of MCI and LOAD. However, the role of OxS as an early prognostic marker of progression to LOAD needs further investigations.
authors: Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy.
authors: Carlo
authors: 0000-0003-4777-6300
authors: C
authors: Cervellati
authors: Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy.
authors: Arianna
authors: A
authors: Romani
authors: Gerontology and Geriatric Research Laboratory, IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Viale Cappuccini 1, 71013 Foggia, Italy.
authors: Davide
authors: D
authors: Seripa
authors: Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy.
authors: Eleonora
authors: E
authors: Cremonini
authors: Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy.
authors: Cristina
authors: C
authors: Bosi
authors: Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy.
authors: Stefania
authors: S
authors: Magon
authors: Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy.
authors: Carlo M
authors: CM
authors: Bergamini
authors: Department of Life Sciences and Biotechnology, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy ; Department of Food and Nutrition, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors: Giuseppe
authors: 0000-0002-8792-0947
authors: G
authors: Valacchi
authors: Geriatrics Unit, Azienda ULSS 16 Padova, S. Antonio Hospital, Via Facciolati 71, 35127 Padova, Italy.
authors: Alberto
authors: A
authors: Pilotto
authors: Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy.
authors: Giovanni
authors: G
authors: Zuliani
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics / Q000473:pathology; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging; D060825:Cognitive Dysfunction / Q000097:blood* / Q000235:genetics / Q000473:pathology; D003704:Dementia / Q000097:blood* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D015227:Lipid Peroxidation / Q000235:genetics; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000235:genetics; D011859:Radiography; D015898:Tomography Scanners, X-Ray Computed
chemical_list: D000975:Antioxidants; D006861:Hydrogen Peroxide