title: Human TP53 polymorphism (rs1042522) modelled in mouse does not affect glucose metabolism and body composition.
abstract: Variation in TP53 has been associated with cancer. The pro-allele of a TP53 polymorphism in codon 72 (rs1042522) has been associated with longevity. Recently, we showed that the same allele might be involved in preservation of glucose metabolism, body composition and blood pressure during ageing. Here, we assessed glucose tolerance and body composition in mice carrying the human polymorphism. Our data do not support the previous findings in humans, suggesting that this polymorphism does not play a major role in development of glucose metabolism and body composition during ageing. Alternatively, the mouse model may not be suitable to validate these rs1042522-associated traits up to the age tested.
authors: National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
authors: Erwin
authors: E
authors: Reiling
authors: Leiden University Medical Center, Department of Toxicogenetics, Leiden, The Netherlands.
authors: Ewoud N
authors: EN
authors: Speksnijder
authors: Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands.
authors: Amanda C M
authors: AC
authors: Pronk
authors: 1] Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands [2] Amphia Hospital, Breda, The Netherlands.
authors: Sjoerd A A
authors: SA
authors: van den Berg
authors: Leiden University Medical Center, Central Animal Facility, Leiden, The Netherlands.
authors: Silvia J W
authors: SJ
authors: Neggers
authors: Leiden University Medical Center, Central Animal Facility, Leiden, The Netherlands.
authors: Ilma
authors: I
authors: Rietbroek
authors: 1] National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands [2] Leiden University Medical Center, Department of Toxicogenetics, Leiden, The Netherlands.
authors: Harry
authors: H
authors: van Steeg
authors: National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
authors: Martijn E T
authors: ME
authors: Dollé
mesh_terms: D000375:Aging; D000483:Alleles; D000818:Animals; D001823:Body Composition; D001835:Body Weight; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D023421:Models, Animal; D020641:Polymorphism, Single Nucleotide; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53; D005947:Glucose