title: Oxidative stress and bone resorption interplay as a possible trigger for postmenopausal osteoporosis.
abstract: The underlying mechanism in postmenopausal osteoporosis (PO) is an imbalance between bone resorption and formation. This study was conducted to investigate whether oxidative stress (OxS) might have a role in this derangement of bone homeostasis. In a sample of 167 postmenopausal women, we found that increased serum levels of a lipid peroxidation marker, hydroperoxides, were negatively and independently associated with decreased bone mineral density (BMD) in total body (r = -0.192, P < 0.05), lumbar spine (r = -0.282, P < 0.01), and total hip (r = -0.282, P < 0.05), as well as with increased bone resorption rate (r = 0.233, P < 0.05), as assessed by the serum concentration of C-terminal telopeptide of type I collagen (CTX-1). On the contrary, the OxS marker failed to be correlated with the serum levels of bone-specific alkaline phosphatase (BAP), that is, elective marker of bone formation. Importantly, multiple regression analysis revealed that hydroperoxides is a determinant factor for the statistical association between lumbar spine BMD and CTX-1 levels. Taken together, our data suggest that OxS might mediate, by enhancing bone resorption, the uncoupling of bone turnover that underlies PO development.
authors: Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy.
authors: Carlo
authors: C
authors: Cervellati
authors: Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124 Ferrara, Italy.
authors: Gloria
authors: G
authors: Bonaccorsi
authors: Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy.
authors: Eleonora
authors: E
authors: Cremonini
authors: Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy.
authors: Arianna
authors: A
authors: Romani
authors: Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124 Ferrara, Italy.
authors: Enrica
authors: E
authors: Fila
authors: Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124 Ferrara, Italy.
authors: Maria Cristina
authors: MC
authors: Castaldini
authors: Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124 Ferrara, Italy.
authors: Stefania
authors: S
authors: Ferrazzini
authors: Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124 Ferrara, Italy ; Department of Morphology, Surgery and Experimental Medicine, Laboratory of Nuclear Medicine, University of Ferrara, Via Aldo Moro 8, Cona, 44124 Ferrara, Italy.
authors: Melchiorre
authors: M
authors: Giganti
authors: Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Via Boschetto 29, 44124 Ferrara, Italy ; Department of Morphology, Surgery and Experimental Medicine, Section of Orthopaedic Clinic, University of Ferrara, Via Aldo Moro 8, Cona, 44124 Ferrara, Italy.
authors: Leo
authors: L
authors: Massari
mesh_terms: D015519:Bone Density / Q000502:physiology; D001862:Bone Resorption / Q000235:genetics / Q000503:physiopathology; D024042:Collagen Type I / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood* / Q000473:pathology; D018384:Oxidative Stress / Q000235:genetics*; D010455:Peptides / Q000097:blood* / Q000235:genetics
chemical_list: D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D006861:Hydrogen Peroxide