title: Effect of Zingiber zerumbet essential oils and zerumbone inhalation on body weight of Sprague Dawley rat.
abstract: Zingiber zerumbet contained the typically essential oils. The research aims to evaluate the effect Z. zerumbet essential oil and zerumbone inhlation on rats body weight, food consumption, parasympathetic nerve activity and brown adipose tissue temperature. The essential oils of Z. zerumbet was isolated from the rhizome of Z. zerumbet. The component in the oil and zerumbone structure was determined by gas chromatography-mass spectroscopy. The structure of zerumbone crystal was determined by nuclear magnetic resonance spectroscopy. The Sprague dawley male adult rats were divided into 4 groups namely Normal Diet (ND) group, High Fat Diet (HFD) group, HFD inhaled Z. zerumbet essential oils group and HFD inhaled zerumbone group. The results showed that inhalation of Z. zerumbet essential oils and zerumbone increased the food consumption as well as increased the body weight. The increasing body weight of rats which inhaled Z. zerumbet essential oils and zerumbone is by decreasing the sympathetic nerve activity. In conclusion, inhaling Z. zerumbet essential oils and zerumbone as the major component of the oils increased the weight gain.
authors: Biopharmaca Research Center, Bogor Agricultural University, Jl. Taman Kencana No 3, Bogor 16151, Indonesia.
authors: I
authors: I
authors: Batubara
authors: Department of Chemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Darmaga Campus, Bogor, Indonesia.
authors: I H
authors: IH
authors: Suparto
authors: Department of Anatomy, Physiology and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia.
authors: S
authors: S
authors: Sadiah
authors: Faculty of Applied Biological Science, Gifu University, 1-1 Yanagido, 501-1193, Japan.
authors: R
authors: R
authors: Matsuoka
authors: Faculty of Applied Biological Science, Gifu University, 1-1 Yanagido, 501-1193, Japan.
authors: T
authors: T
authors: Mitsunaga
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects; D000280:Administration, Inhalation; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004435:Eating / Q000187:drug effects / Q000502:physiology; D008297:Male; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000737:chemistry*; D010275:Parasympathetic Nervous System / Q000187:drug effects; D053147:Plant Exudates / Q000008:administration & dosage / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012717:Sesquiterpenes / Q000008:administration & dosage* / Q000737:chemistry*; D015430:Weight Gain / Q000187:drug effects; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: D009822:Oils, Volatile; D053147:Plant Exudates; D012717:Sesquiterpenes; C403304:zerumbone