title: Effects of reward sensitivity and regional brain volumes on substance use initiation in adolescence.
abstract: This longitudinal study examines associations between baseline individual differences and developmental changes in reward [i.e. behavioral approach system (BAS)] sensitivity and relevant brain structures' volumes to prospective substance use initiation during adolescence. A community sample of adolescents ages 15-18 with no prior substance use was assessed for substance use initiation (i.e. initiation of regular alcohol use and/or any use of other substances) during a 2-year follow-up period and for alcohol use frequency in the last year of the follow-up. Longitudinal 'increases' in BAS sensitivity were associated with substance use initiation and increased alcohol use frequency during the follow-up. Moreover, adolescents with smaller left nucleus accumbens at baseline were more likely to initiate substance use during the follow-up period. This study provides support for the link between developmental increases in reward sensitivity and substance use initiation in adolescence. The study also emphasizes the potential importance of individual differences in volumes of subcortical regions and their structural development for substance use initiation during adolescence.
authors: Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA, Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands, and Department of Psychiatry, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA snezana.urosevic@gmail.com.
authors: Snežana
authors: S
authors: Urošević
authors: Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA, Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands, and Department of Psychiatry, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.
authors: Paul
authors: P
authors: Collins
authors: Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA, Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands, and Department of Psychiatry, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.
authors: Ryan
authors: R
authors: Muetzel
authors: Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA, Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands, and Department of Psychiatry, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.
authors: Ann
authors: A
authors: Schissel
authors: Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA, Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands, and Department of Psychiatry, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.
authors: Kelvin O
authors: KO
authors: Lim
authors: Department of Psychology, University of Minnesota-Twin Cities, Minneapolis, MN 55455, USA, Department of Child and Adolescent Psychiatry, Erasmus Medical Center-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands, and Department of Psychiatry, University of Minnesota-Twin Cities, Minneapolis, MN 55454, USA.
authors: Monica
authors: M
authors: Luciana
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D041923:Adolescent Development; D000437:Alcoholism / Q000523:psychology; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007206:Individuality; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008297:Male; D002189:Marijuana Abuse / Q000523:psychology; D009714:Nucleus Accumbens / Q000033:anatomy & histology / Q000254:growth & development; D011446:Prospective Studies; D012201:Reward; D019966:Substance-Related Disorders / Q000523:psychology*; D064424:Tobacco Use / Q000523:psychology
keywords: adolescence; behavioral approach system (BAS); reward sensitivity; substance use initiation