title: High prevalence of diabetes mellitus in a five-generation Chinese family with Huntington's disease.
abstract: Huntington's disease (HD) is associated with diabetes mellitus (DM) in population studies, but no case has been reported in a large HD family. We report a case of a five-generation Chinese family who is afflicted by both HD and DM. The prevalence of DM in HD of this family was high (72.7%). The diagnosis of HD in 11 family members was confirmed by the genetic test of the proband who had 42 CAG repeats. Furthermore, the proband's daughter had abnormal locus at G3460T in MT-ND1 among mtDNA genome. Our case report suggests a genetic link between HD and DM.
authors: Department of Neurology, Chinese PLA General Hospital, Beijing, P.R. China.
authors: Yueqing
authors: Y
authors: Hu
authors: Department of Neurology, Chinese PLA General Hospital, Beijing, P.R. China.
authors: Jingyao
authors: J
authors: Liang
authors: Department of Neurology, Chinese PLA General Hospital, Beijing, P.R. China.
authors: Shengyuan
authors: S
authors: Yu
mesh_terms: D002681:China; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D005192:Family Health; D005260:Female; D005820:Genetic Testing; D006801:Humans; D000071058:Huntingtin Protein; D006816:Huntington Disease / Q000150:complications* / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics; D015995:Prevalence; D019680:Trinucleotide Repeat Expansion / Q000235:genetics
chemical_list: C086055:HTT protein, human; D000071058:Huntingtin Protein; D009419:Nerve Tissue Proteins
keywords: Diabetes mellitus; Huntington disease; genes; pathogenesis