title: Pre-eclampsia and cardiovascular disease.
abstract: Heart disease is the leading cause of death in women in all countries. A history of pre-eclampsia, one of the most deadly hypertensive complications of pregnancy, increases cardiovascular risk by two to four times, which is comparable with the risk induced by smoking. Substantial epidemiological data reveal that pregnancy-related hypertensive complications are associated with a predisposition to chronic hypertension, premature heart attacks, strokes, and renal complications. In this review, we summarize clinical studies that demonstrate this relationship and also discuss the pathogenesis of these long-term complications of pre-eclampsia. Future studies should focus on strategies to prevent the progression of cardiovascular disease in women exposed to pre-eclampsia, thereby improving long-term cardiovascular health in women.
authors: Division of Nephrology/Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RN 370D, Boston, MA 02215, USA.
authors: Christina W
authors: CW
authors: Chen
authors: Iris Z
authors: IZ
authors: Jaffe
authors: S Ananth
authors: SA
authors: Karumanchi
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000453:epidemiology* / Q000209:etiology*; D011247:Pregnancy; D011507:Proteinuria / Q000150:complications / Q000453:epidemiology; D051436:Renal Insufficiency, Chronic / Q000150:complications; D012307:Risk Factors
keywords: Angiogenesis; Cardiovascular disease; Chronic kidney disease; Hypertension; Pre-eclampsia; Proteinuria; Stroke; sFlt1