title: Highly uniform and stable cerasomal microcapsule with good biocompatibility for drug delivery.
abstract: Efforts to improve the stability of liposomes have recently led to the development of organic-inorganic liposomal cerasomes. However, the uncontrollable size of cerasomes has greatly limited their biomedical applications. In this study, a novel strategy was introduced to fabricate hybrid liposomal cerasomes with high stability and uniform size. The hybrid lipids were first deposited onto CaCO3 microspheres through electrostatic interactions and self-assembly, and then the CaCO3 core was removed to obtain hollow microcapsules, i.e. the cerasomes. The species of the lipid oligomers was detected by MALDI-TOF-MS, which demonstrates the existence of siloxane network on microcapsules' surface. Anticancer drug doxorubicin hydrochloride (DOX) loaded cerasomal microcapsule (DLCM) exhibited an initial burst release behavior followed by the sustained release and remarkably high stability towards surfactant solubilization and long term storage. The DLCM displayed a pH-dependent and sustained DOX release profile in vitro, which can be well explained using a well established mathematical model. Our results indicate that these novel cerasomal microcapsules have great potential to be applied as drug delivery system in cancer therapy.
authors: Department of Biomedical Engineering, College of Engineering, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors: Chun-Yang
authors: CY
authors: Zhang
authors: Department of Biomedical Engineering, College of Engineering, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: caozhong@mail.sysu.edu.cn.
authors: Zhong
authors: Z
authors: Cao
authors: Department of Biomedical Engineering, College of Engineering, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors: Wen-Jian
authors: WJ
authors: Zhu
authors: Department of Biomedical Engineering, College of Engineering, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors: Jie
authors: J
authors: Liu
authors: Department of Biomedical Engineering, College of Engineering, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors: Qing
authors: Q
authors: Jiang
authors: Department of Biomedical Engineering, College of Engineering, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
authors: Xin-Tao
authors: XT
authors: Shuai
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D002214:Capsules / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002516:Ceramics / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D000903:Antibiotics, Antineoplastic; D001672:Biocompatible Materials; D002214:Capsules; D004337:Drug Carriers; D008081:Liposomes; D004317:Doxorubicin
keywords: Drug delivery; Liposomes; Microcapsule; Stability; Uniform size