title: Possible anticancer activity of rosuvastatine, doxazosin, repaglinide and oxcarbazepin.
abstract: BACKGROUND
  Rosuvastatine, doxazosin, repaglinide and oxcarbazepin are therapeutic drugs available in the market for the treatment of different diseases. Potential to display antitumor activities has also been suggested. The aim of the current study was to evaluate their in vitro effects on some human transformed cell lines.
  
  
  METHODS
  Cytotoxicity of the four drugs was tested in MCF-7, HeLa and HepG2 cells by the neutral red assay method and also the effect of rosuvastatine and doxazosin against Ehrlich Ascities Carcinoma Cells (EACC) by trypan blue assay.
  
  
  RESULTS
  Rosuvastatine exerted the greatest cytotoxic effect against HepG2 cells with an IC50 value of 58.7±69.3; in contrast doxazosin showed least activity with IC50=104.4 ±115.7. Repaglinide inhibited the growth of both HepG2 and HeLa cells with IC50 values of 87.6±117.5 and 89.3±119.5, respectively. Oxcarbazepine showed a potent cytotoxicity against both HeLa (IC50=19.4±43.9) and MCF7 cancer cells ((IC50=22±35.7).On the other hand the growth of EACC was completely inhibited by doxazosine (100% inhibition) while rosuvastatine had weak inhibitory activity (11.6%) .
  
  
  CONCLUSIONS
  The four tested drugs may have cytotoxic effects against hepatic, breast and cervical carcinoma cells; also doxazosine may inhibit the growth of endometrial cancer cells. Further investigations in animals are needed to confirm these results.
authors: Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University , Helwan, Egypt E-mail : felsharkawi@gmail.com.
authors: Fathia Zaky
authors: FZ
authors: El Sharkawi
authors: Hany Abdelaziz
authors: HA
authors: El Shemy
authors: Hussein Moustafa
authors: HM
authors: Khaled
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D002220:Carbamazepine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects*; D017292:Doxazosin / Q000494:pharmacology*; D005464:Fluorobenzenes / Q000494:pharmacology*; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D000078330:Oxcarbazepine; D010880:Piperidines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D000959:Antihypertensive Agents; D000970:Antineoplastic Agents; D002219:Carbamates; D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007004:Hypoglycemic Agents; D010880:Piperidines; D011743:Pyrimidines; D013449:Sulfonamides; D002220:Carbamazepine; C072379:repaglinide; D000068718:Rosuvastatin Calcium; D017292:Doxazosin; D000078330:Oxcarbazepine