title: Impact of atypical hyperplasia at margins of breast-conserving surgery on the recurrence of breast cancer.
abstract: OBJECTIVE
  Atypical hyperplasia (AH) is associated with a relatively higher risk of subsequent development of cancer. It remains controversial whether it is necessary to re-excise AH found at surgical margins during breast-conserving surgery (BCS). The aim of this study was to determine the impact of atypical ductal/lobular hyperplasia found at the margins during BCS on the prognosis of early-stage breast cancer patients.
  
  
  METHODS
  A retrospective analysis comparing patients with AH and receiving no further surgical treatment (n = 233) to those without AH at the margins during BCS (n = 158) was performed.
  
  
  RESULTS
  At a median follow-up of 76 months, the 5- and 8-year rates of ipsilateral breast tumor recurrence (IBTR) were 3.26 and 8.79% for women with AH and 2.56 and 8.95% for women without AH, respectively. There were no significant differences between the two groups in terms of IBTR (p = 0.803), distant-metastasis-free survival (DMFS) (p = 0.749), or overall survival (OS) (p = 0.165). Moreover, no significant differences were found in IBTR, DMFS, or OS between patients with severe atypical hyperplasia (n = 86) and those without AH (n = 158) (p = 0.81, 0.82, and 0.78, respectively). Additionally, young women or those with ductal carcinoma in situ or triple-negative breast cancer with AH involving margins did not have a higher IBTR rate when compared to similar patients without AH.
  
  
  CONCLUSIONS
  This study suggests that AH found at the margins during BCS does not increase the risk of subsequently developing an IBTR. There is not enough evidence for re-excision of AH found at the margins during BCS in patients with early-stage breast cancer.
authors: Breast Tumor Center, Sun Yat-Sen Memorial Hospital, 33 Yingfeng Road, Guangzhou, 510288, China.
authors: Shunrong
authors: S
authors: Li
authors: Jieqiong
authors: J
authors: Liu
authors: Yaping
authors: Y
authors: Yang
authors: Yunjie
authors: Y
authors: Zeng
authors: Heran
authors: H
authors: Deng
authors: Haixia
authors: H
authors: Jia
authors: Qian
authors: Q
authors: Li
authors: Huiyi
authors: H
authors: Feng
authors: Yangyang
authors: Y
authors: Li
authors: Erwei
authors: E
authors: Song
authors: Qiang
authors: Q
authors: Liu
authors: Fengxi
authors: F
authors: Su
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology* / Q000601:surgery; D018275:Carcinoma, Lobular / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia / Q000473:pathology* / Q000601:surgery; D015412:Mastectomy, Segmental / Q000009:adverse effects*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000209:etiology*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate