title: The use of 17-hydroxy progesterone in women with arrested preterm labor: a randomized clinical trial.
abstract: BACKGROUND
  The use of 17-alpha-hydroxyprogesterone caproate (17 P) has been shown to reduce preterm delivery in women who have had a prior preterm birth. The role of 17 P in women with arrested preterm labor is less certain.
  
  
  OBJECTIVE
  To compare the preterm birth rate and neonatal outcome in women with arrested preterm labor randomized to receive 17 P or placebo.
  
  
  METHODS
  Women with arrested preterm labor were randomized to weekly injections of either 17 P (250 mg) or placebo. Maternal and neonatal outcome were evaluated.
  
  
  RESULTS
  Forty-five singleton pregnancies were randomized after successful tocolysis; 22 received 17 P while 23 got placebo. Gestational age at delivery (p = 0.067) and the interval from treatment to delivery (p = 0.233) were not affected by 17 P. Significantly less women in the 17 P group delivered at <34 weeks (14 versus 21, p = 0.035). There was also a significant reduction in the risk of neonatal sepsis (p = 0.047) and gr III/IV intraventricular hemorrhage (IVH) (p = 0.022) in the 17 P group.
  
  
  CONCLUSIONS
  In this study, 17 P did not delay the interval to delivery after successful preterm labor, but births <34 weeks as well as neonatal sepsis and IVH were reduced by 17 P treatment.
authors: Departments of Obstetrics and Gynecology, Willis Knighton Health System , Shreveport, LA , USA .
authors: Christian M
authors: CM
authors: Briery
authors: Chad K
authors: CK
authors: Klauser
authors: Rick W
authors: RW
authors: Martin
authors: Everett F
authors: EF
authors: Magann
authors: Suneet P
authors: SP
authors: Chauhan
authors: John C
authors: JC
authors: Morrison
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D001034:Apgar Score; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D047928:Premature Birth / Q000188:drug therapy / Q000453:epidemiology; D015145:Tocolysis / Q000379:methods*
chemical_list: D006908:Hydroxyprogesterones; D000077713:17 alpha-Hydroxyprogesterone Caproate
keywords: 17 hydroxyprogesterone; neonatal morbidity; preterm delivery; preterm labor