title: Systematic review and meta-analysis of the association between complement factor H I62V polymorphism and risk of polypoidal choroidal vasculopathy in Asian populations.
abstract: OBJECTIVE
  To investigate whether the polymorphism rs800292 (184G>A, I62V) in the complement factor H gene is associated with polypoidal choroidal vasculopathy (PCV) and the genetic difference between PCV and neovascular age-related macular degeneration (nAMD), in Asian populations.
  
  
  METHODS
  A comprehensive literature search was performed in PubMed, Medline, Web of Science, and reference lists. A system review and meta-analysis of the association between I62V and PCV and/or nAMD were performed from 8 studies involving 5,062 subjects. The following data from individual studies were extracted and analyzed: 1) comparison of I62V polymorphisms between PCV and controls; 2) comparison of I62V polymorphisms between PCV and nAMD. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed-effects models. The Q-statistic test was used to assess heterogeneity, and Egger's test was used to evaluate publication bias. Sensitivity analysis and cumulative meta-analysis were also performed.
  
  
  RESULTS
  The I62V polymorphism showed a significant summary OR1 for genotype GA+GG versus homozygous genotype AA was 3.18 (95% CI, 2.51-4.04, P<0.00001), the OR2 of heterozygous genotype GA versus AA was 2.29 (95% CI: 1.79-2.94, P<0.00001), the OR3 of homozygous genotype GG versus AA was 4.42 (95% CI: 3.45-5.67, P<0.00001), and the OR4 of allele G versus A was 2.04 (95% CI: 1.85-2.26, P<0.00001). Sensitivity analysis indicated the robustness of our findings, and evidence of publication bias was not observed in our meta-analysis. Cumulative meta-analysis revealed that the summary ORs were stable. There was no significant difference in every genetic model between PCV and nAMD (n = 5, OR1 = 0.92, OR2 = 0.96, OR3 = 0.90, OR4 = 0.94).
  
  
  CONCLUSIONS
  Our analysis provides evidence that the I62V polymorphism is associated with an increased risk of PCV. The variant of I62V could be a promising genetic biomarker of PCV in Asian populations.
authors: Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China ; Departments of Molecular Genetics, University of Florida, Gainesville, Florida, United States of America.
authors: Zhao-Yang
authors: ZY
authors: Wang
authors: Departments of Molecular Genetics, University of Florida, Gainesville, Florida, United States of America.
authors: Keke
authors: K
authors: Zhao
authors: Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
authors: Jingwei
authors: J
authors: Zheng
authors: Departments of Molecular Genetics, University of Florida, Gainesville, Florida, United States of America.
authors: Brian
authors: B
authors: Rossmiller
authors: Departments of Molecular Genetics, University of Florida, Gainesville, Florida, United States of America.
authors: Cristhian
authors: C
authors: Ildefonso
authors: Departments of Molecular Genetics, University of Florida, Gainesville, Florida, United States of America.
authors: Manas
authors: M
authors: Biswal
authors: Department of Ophthalmology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors: Pei-quan
authors: PQ
authors: Zhao
mesh_terms: D000368:Aged; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics*; D020256:Choroidal Neovascularization / Q000235:genetics*; D017242:Complement Factor H / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias; D012307:Risk Factors
chemical_list: D017242:Complement Factor H