title: Temozolomide for treatment of brain metastases: A review of 21 clinical trials.
abstract: Brain metastases from solid tumours are associated with poor prognosis despite aggressive treatment. Temozolomide can be used for the treatment of glioblastoma multiforme as well as melanoma. It has also been shown to have activity in patients with brain metastases from various malignancies, since it can cross the blood-brain barrier. To better understand the efficacy of temozolomide in the treatment of brain metastases, we carried out a review of 21 published clinical trials to determine whether temozolomide would benefit patients with brain metastases from solid tumours. Information regarding complete response, partial response, stable disease, objective response and objective response rate were collected to assess clinical outcomes. A modest therapeutic effect was observed when temozolomide was used as a single agent, however, the combination of temozolomide with whole-brain radiotherapy and/or other anticancer drugs exhibited encouraging activity. Thus, future high quality studies are warranted to confirm our findings.
authors: Wei Zhu, Li Zhou, Jia-Qi Qian, Tian-Zhu Qiu, Yong-Qian Shu, Ping Liu, Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors: Wei
authors: W
authors: Zhu
authors: Wei Zhu, Li Zhou, Jia-Qi Qian, Tian-Zhu Qiu, Yong-Qian Shu, Ping Liu, Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors: Li
authors: L
authors: Zhou
authors: Wei Zhu, Li Zhou, Jia-Qi Qian, Tian-Zhu Qiu, Yong-Qian Shu, Ping Liu, Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors: Jia-Qi
authors: JQ
authors: Qian
authors: Wei Zhu, Li Zhou, Jia-Qi Qian, Tian-Zhu Qiu, Yong-Qian Shu, Ping Liu, Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors: Tian-Zhu
authors: TZ
authors: Qiu
authors: Wei Zhu, Li Zhou, Jia-Qi Qian, Tian-Zhu Qiu, Yong-Qian Shu, Ping Liu, Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors: Yong-Qian
authors: YQ
authors: Shu
authors: Wei Zhu, Li Zhou, Jia-Qi Qian, Tian-Zhu Qiu, Yong-Qian Shu, Ping Liu, Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors: Ping
authors: P
authors: Liu
keywords: Brain metastases; Clinical outcomes; Clinical trials; Solid tumours; Temozolomide