title: Synthesis of chitosan derivative with diethyldithiocarbamate and its antifungal activity.
abstract: With an aim to discover novel chitosan derivatives with enhanced antifungal properties compared with chitosan. Diethyl dithiocarbamate chitosan (EtDTCCS) was investigated and its structure was well identified. The antifungal activity of EtDTCCS against Alternaria porri (A. porri), Gloeosporium theae sinensis Miyake (G. theae sinensis), and Stemphylium solani Weber (S. solani) was tested at 0.25, 0.5, and 1.0 mg/mL, respectively. Compared with plain chitosan, EtDTCCS shows better inhibitory effect with 93.2% inhibitory index on G. theae sinensis at 1.0 mg/mL, even stronger than for polyoxin (82.5%). It was inferred derivatives of this kind may find potential applications for the treatment of various crop-threatening diseases.
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Yukun
authors: Y
authors: Qin
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Ronge
authors: R
authors: Xing
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address: sliu@qdio.ac.cn.
authors: Song
authors: S
authors: Liu
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Kecheng
authors: K
authors: Li
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; School of Chemistry & Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003, China.
authors: Linfeng
authors: L
authors: Hu
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Huahua
authors: H
authors: Yu
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
authors: Xiaolin
authors: X
authors: Chen
authors: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address: pcli@qdio.ac.cn.
authors: Pengcheng
authors: P
authors: Li
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D048271:Chitosan / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004050:Ditiocarb / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D010944:Plants / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D048271:Chitosan; D004050:Ditiocarb
keywords: Antifungal activity; Dithiocarbamate chitosan; Synthesis