title: Treatment of chronic inflammatory demyelinating polyneuropathy with high dose intravenous methylprednisolone monthly for five years: 10-Year follow up.
abstract: OBJECTIVE
  Although various modalities of treatment of chronic inflammatory demyelinating polyradiculopathy (CIDP) there are not any treatment protocol agreed.
  
  
  METHODS
  We retrospectively evaluated the 20 CIDP patients (14 male, 6 female). Five patients were excluded from the study because they could not continue their treatments due to various problems during the treatment. The remaining 15 patients treated with monthly high dose intravenous methyl prednisolone for five years (IVMP) and followed up for 10 years.
  
  
  RESULTS
  The mean age of the patients was 48.1±14.6 years. The mean duration of disease was 6.8±3.1 years. We were found statistically significant difference between the pre-treatment and sixth month modified Rankin scores (p<0.001). Similarly, significant improvement was observed at the end of first, fourth and fifth years of treatment. Statistically significant difference was found between baseline and tenth year modified Rankin scores of 12 patients who were treated with only IVMP during 10 years follow-up.
  
  
  CONCLUSIONS
  Long-term monthly IVMP pulse therapy seems to be very effective in the treatment of CIDP.
authors: Dr. Lütfi Kırdar Kartal Training and Research Hospital, Department of Neurology, Şemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890 İstanbul, Turkey.
authors: Ülkü Türk
authors: ÜT
authors: Börü
authors: Dr. Lütfi Kırdar Kartal Training and Research Hospital, Department of Neurology, Şemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890 İstanbul, Turkey.
authors: Hülya
authors: H
authors: Erdoğan
authors: Department of Neurology, Namık Kemal University, Faculty of Medicine, Değirmenaltı Yerleşkesi, 59030 Tekirdağ, Turkey.
authors: Recep
authors: R
authors: Alp
authors: Department of Public Health, Marmara University, Faculty of Medicine, Selimiye Mah. Tıbbiye Cad. No. 38, 34668 İstanbul, Turkey.
authors: Mustafa
authors: M
authors: Taşdemir
authors: Dr. Lütfi Kırdar Kartal Training and Research Hospital, Department of Neurology, Şemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890 İstanbul, Turkey. Electronic address: serhan_yildirim@yahoo.com.
authors: Serhan
authors: S
authors: Yıldırım
authors: Dr. Lütfi Kırdar Kartal Training and Research Hospital, Department of Neurology, Şemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890 İstanbul, Turkey.
authors: Adnan
authors: A
authors: Bilgiç
authors: Dr. Lütfi Kırdar Kartal Training and Research Hospital, Department of Neurology, Şemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890 İstanbul, Turkey.
authors: Arda
authors: A
authors: Duman
authors: Dr. Lütfi Kırdar Kartal Training and Research Hospital, Department of Neurology, Şemsi Denizer Cad. E-5 Karayolu Cevizli Mevkii, 34890 İstanbul, Turkey.
authors: Alper
authors: A
authors: Arslan
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001774:Blood Chemical Analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007275:Injections, Intravenous; D008134:Long-Term Care; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000188:drug therapy*; D020127:Recovery of Function; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D016756:Immunoglobulins, Intravenous; D008775:Methylprednisolone
keywords: Chronic inflammatory demyelinating polyradiculopathy; Methylprednisolone