title: Enantioselective addition of nitromethane to 2-acylpyridine N-oxides. Expanding the generation of quaternary stereocenters with the Henry reaction.
abstract: The direct asymmetric Henry reaction with prochiral ketones, leading to tertiary nitroaldols, is an elusive reaction so far limited to a reduced number of reactive substrates such as trifluoromethyl ketones or α-keto carbonyl compounds. Expanding the scope of this important reaction, the direct asymmetric addition of nitromethane to 2-acylpyridine N-oxides catalyzed by a BOX-Cu(II) complex to give the corresponding pyridine-derived tertiary nitroaldols having a quaternary stereogenic center with variable yields and good enantioselectivity, is described.
authors: Departament de Química Orgànica, Facultat de Química-Universitat de València , C/Dr. Moliner 50, E-46100Burjassot (València), Spain.
authors: Melireth
authors: M
authors: Holmquist
authors: Gonzalo
authors: G
authors: Blay
authors: M Carmen
authors: MC
authors: Muñoz
authors: José R
authors: JR
authors: Pedro