title: Sixth and seventh tumor-node-metastasis staging system compared in gastric cancer patients.
abstract: OBJECTIVE
  To investigate the clinical relevance and prognosis regarding survival according to the changes of the tumor-node-metastasis (TNM) in gastric cancer patients.
  
  
  METHODS
  We retrospectively studied 347 consecutive subjects who underwent surgery for gastric adenocarcinoma at the Division of General Surgery, Hospital of Busto Arsizio, Busto Arsizio, Italy between June 1998 and December 2009. Patients who underwent surgery without curative intent, patients with tumors of the gastric stump and patients with tumors involving the esophagus were excluded for survival analysis. Patients were staged according to the 6(th) and 7(th) edition TNM criteria; 5-year overall survival rates were investigated, and the event was defined as death from any cause.
  
  
  RESULTS
  After exclusion, our study population included 241 resected patients with curative intent for gastric adenocarcinoma. The 5-year overall survival (5-year OS) rate of all the patients was 52.8%. The diagnosed stage differed in 32% of 241 patients based on the TNM edition used for the diagnosis. The patients in stage II according to the 6(th) edition who were reclassified as stage III had significantly worse prognosis than patients classified as stage II (5-year OS, 39% vs 71%). According to the 6(th) edition, 135 patients were classifed as T2, and 75% of these patients migrated to T3 and exhibited a significantly worse prognosis than those who remained T2, regardless of lymph node involvement (37% vs 71%). The new N1 patients exhibited a better prognosis than the previous N1 patients (67% vs 43%).
  
  
  CONCLUSIONS
  7(th) TNM allows new T2 and N1 patients to be selected with better prognosis, which leads to different staging. New stratification is important in multimodal therapy.
authors: Tommaso Zurleni, Elson Gjoni, Andrea Ballabio, Roberto Casieri, Paola Ceriani, Francesco Zurleni, Department of General Surgery, Hospital of Busto Arsizio, 21052 Busto Arsizio, Italy.
authors: Tommaso
authors: T
authors: Zurleni
authors: Tommaso Zurleni, Elson Gjoni, Andrea Ballabio, Roberto Casieri, Paola Ceriani, Francesco Zurleni, Department of General Surgery, Hospital of Busto Arsizio, 21052 Busto Arsizio, Italy.
authors: Elson
authors: E
authors: Gjoni
authors: Tommaso Zurleni, Elson Gjoni, Andrea Ballabio, Roberto Casieri, Paola Ceriani, Francesco Zurleni, Department of General Surgery, Hospital of Busto Arsizio, 21052 Busto Arsizio, Italy.
authors: Andrea
authors: A
authors: Ballabio
authors: Tommaso Zurleni, Elson Gjoni, Andrea Ballabio, Roberto Casieri, Paola Ceriani, Francesco Zurleni, Department of General Surgery, Hospital of Busto Arsizio, 21052 Busto Arsizio, Italy.
authors: Roberto
authors: R
authors: Casieri
authors: Tommaso Zurleni, Elson Gjoni, Andrea Ballabio, Roberto Casieri, Paola Ceriani, Francesco Zurleni, Department of General Surgery, Hospital of Busto Arsizio, 21052 Busto Arsizio, Italy.
authors: Paola
authors: P
authors: Ceriani
authors: Tommaso Zurleni, Elson Gjoni, Andrea Ballabio, Roberto Casieri, Paola Ceriani, Francesco Zurleni, Department of General Surgery, Hospital of Busto Arsizio, 21052 Busto Arsizio, Italy.
authors: Luca
authors: L
authors: Marzoli
authors: Tommaso Zurleni, Elson Gjoni, Andrea Ballabio, Roberto Casieri, Paola Ceriani, Francesco Zurleni, Department of General Surgery, Hospital of Busto Arsizio, 21052 Busto Arsizio, Italy.
authors: Francesco
authors: F
authors: Zurleni
keywords: Gastric cancer; Lymphadenectomy; Prognostic factor; Survival analysis; Tumor-node-metastasis staging system