title: Evaluation of neuroprotective effect of glucagon-like peptide 1 analogs using neuroimaging.
abstract: There is increasing evidence to suggest that glucagon-like peptide 1 (GLP1) analogs are neuroprotective in animal models. In transgenic mice, both insulin and GLP1 analogs reduced inflammation, increased stem cell proliferation, reduced apoptosis, and increased dendritic growth. Furthermore, insulin desensitization was also observed in these animals, and reduced glucose uptake in the brain, as shown on FDG-PET imaging. In this review we discussed the role of PET and MRI in evaluating the effect of GLP1 analogs in disease progression in both Alzheimer's and Parkinson's disease. We have also discussed the potential novel PET markers that will allow us to understand the mechanism by which GLP1 exerts its effects.
authors: Neurology Imaging Unit, Imperial College London, Hammersmith Campus, London, UK.
authors: Grazia D
authors: GD
authors: Femminella
authors: Neurology Imaging Unit, Imperial College London, Hammersmith Campus, London, UK. Electronic address: paul.edison@imperial.ac.uk.
authors: Paul
authors: P
authors: Edison
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D004195:Disease Models, Animal; D052216:Glucagon-Like Peptide 1 / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D019636:Neurodegenerative Diseases / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D059906:Neuroimaging; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011877:Radionuclide Imaging
chemical_list: D018696:Neuroprotective Agents; D052216:Glucagon-Like Peptide 1
keywords: Alzheimer's disease; Amyloid imaging; FDG-PET; Glucagon-like peptide 1; Liraglutide; MRI; Neuroimaging; Neuroinflammation; Parkinson's disease