title: Replication of results of a genome-wide association study on lung cancer survival in a Korean population.
abstract: Recently, a genome-wide association study (GWAS) identified single nucleotide polymorphisms (SNPs) that may influence the prognosis of early-stage non-small cell lung cancer (NSCLC) in Caucasians. We attempted to replicate the impact of genetic variants identified in the GWAS on lung cancer survival in a Korean population. A total of 363 patients with surgically resected NSCLCs were enrolled, and 12 SNPs were genotyped using the SEQUENOM MassARRAY iPLEX assay, TaqMan assay, or a polymerase chain reaction-restriction fragment length polymorphism analysis. The association between genotypes and overall survival (OS) was analyzed. Among the 12 SNPs, the rs6034368T>C was associated with OS. Patients with the rs6034368C allele showed a better OS than the patients with the rs6034368T allele (adjusted hazard ratio = 0.72, confidence interval = 0.56-0.93, P = 0.01). The rs12446308A>G had an effect on OS, but it was marginally significant (under a codominant model, adjusted hazard ratio = 1.85, confidence interval = 0.98-3.47, P = 0.06). We identified that the rs6034368T>C was associated with survival in early-stage NSCLC in a Korean population.
authors: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea; Lung Cancer Center, Kyungpoook National University Medical Center, Daegu, Korea.
authors: Seung Soo
authors: SS
authors: Yoo
authors: Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Mi Jeong
authors: MJ
authors: Hong
authors: Lung Cancer Center, Kyungpoook National University Medical Center, Daegu, Korea; Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Hyo-Sung
authors: HS
authors: Jeon
authors: Department of Preventive Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Won Kee
authors: WK
authors: Lee
authors: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea; Lung Cancer Center, Kyungpoook National University Medical Center, Daegu, Korea.
authors: Shin Yup
authors: SY
authors: Lee
authors: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Jaehee
authors: J
authors: Lee
authors: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Seung Ick
authors: SI
authors: Cha
authors: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Chang Ho
authors: CH
authors: Kim
authors: Lung Cancer Center, Kyungpoook National University Medical Center, Daegu, Korea; Department of Thoracic Surgery, Kyungpook National University School of Medicine, Daegu, Korea.
authors: Eungbae
authors: E
authors: Lee
authors: Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea; Lung Cancer Center, Kyungpoook National University Medical Center, Daegu, Korea; Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea. Electronic address: jaeyong@knu.ac.kr.
authors: Jae Yong
authors: JY
authors: Park
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D056910:Republic of Korea; D017422:Sequence Analysis, DNA; D016019:Survival Analysis
keywords: Genome-wide association study; non-small cell lung cancer; polymorphism; survival