title: Interferon gamma polymorphisms associated with susceptibility to tuberculosis in a Han Taiwanese population.
abstract: BACKGROUND
  Polymorphisms of the interferon gamma (IFN-γ) gene are associated with the risk of tuberculosis (TB) in different populations. However, the genetic susceptibility to TB in Han Chinese living in Taiwan is still unknown. The purpose of this study is to evaluate whether the polymorphisms of the IFN-γ gene are associated with TB in Han Taiwanese.
  
  
  METHODS
  A total of 200 TB patients and 202 age-matched non-TB individuals were enrolled. Five tag single nucleotide polymorphisms (tSNPs) and rs2430561 (+874) of IFN-γ were selected from a public database. The genotypes were determined using polymerase chain reaction assays.
  
  
  RESULTS
  Three IFN-γ polymorphisms in intron 3, rs1861494 and rs2069718, and rs2430561 in interon 1 were strongly associated with TB. The C carrier (CT+TT) of rs1861494, TT homozygous of rs2069718, and AA homozygous of rs2430561 were risk genotypes for susceptibility to TB.
  
  
  CONCLUSIONS
  The IFN-γ polymorphisms, rs1861494, rs2069718, and rs2430561, may confer the risk of TB in Han Taiwanese.
authors: Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Life Sciences, National Central University, Taoyuan, Taiwan.
authors: Shih-Wei
authors: SW
authors: Lee
authors: Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
authors: Tzu-Yi
authors: TY
authors: Chuang
authors: Department of Internal Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.
authors: Hsiu-Han
authors: HH
authors: Huang
authors: Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
authors: Kuei-Fang
authors: KF
authors: Lee
authors: Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan.
authors: Tina Tu-Wen
authors: TT
authors: Chen
authors: Department of Life Sciences, National Central University, Taoyuan, Taiwan.
authors: Yung-Hsi
authors: YH
authors: Kao
authors: Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address: lshwu@mail.tcu.edu.tw.
authors: Lawrence Shih-Hsin
authors: LS
authors: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology
chemical_list: D007371:Interferon-gamma
keywords: IFN-γ; Polymorphism; Tuberculosis