title: 3-Amino-N-adamantyl-3-methylbutanamide derivatives as 11β-hydroxysteroid dehydrogenase 1 inhibitor.
abstract: Many adamantane derivatives have been demonstrated to function as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. 3-Amino-N-adamantyl-3-methylbutanamide derivatives were optimized by structure-based drug design. Compound 8j exhibited a good in vitro and ex vivo inhibitory activity against both human and mouse 11β-HSD1.
authors: College of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, Yonsei University, 162-1 Songdo-dong, Yeonsu-gu, Incheon 406-840, Republic of Korea.
authors: Younho
authors: Y
authors: Lee
authors: R&D Center, Ahn Gook Pharm., Gyeonggi Bio-Center, Suwon, Gyeonggi-do 443-766, Republic of Korea.
authors: Yong June
authors: YJ
authors: Shin
authors: Institute for New Drug Development, Division of Life Sciences, Incheon National University, Incheon 406-772, Republic of Korea. Electronic address: skahn@incheon.ac.kr.
authors: Soon Kil
authors: SK
authors: Ahn
mesh_terms: D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000577:Amides / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D051379:Mice; D062105:Molecular Docking Simulation; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D004791:Enzyme Inhibitors; D043205:11-beta-Hydroxysteroid Dehydrogenase Type 1
keywords: 11β-Hydroxysteroid dehydrogenase type 1 inhibitor; 3-Amino-N-adamantyl-3-methylbutanamide; Anti-diabetes; Structure-based drug design