title: Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people.
abstract: BACKGROUND
  Conjugated linoleic acids (CLAs) have shown beneficial effects in weight control therapy however this relation is not clear.
  
  
  OBJECTIVE
  The aim of the study was to examine the effects and safety of 3g of a 1:1 mix of c9-t11 and t10-c12 on weight control and body composition in healthy overweight individuals.
  
  
  METHODS
  A prospective, placebo-controlled, randomised double-blind, parallel clinical trial lasting 24 weeks was carried out in 38 volunteers (29w, 9m) aged 30-55 years and BMI ≥27-<30 kg/m2 who consumed 200 ml/day of skimmed milk with 3g of CLAs or 3g olive oil (placebo). Anthropometric, biochemical and dual x-ray absorptiometry (DXA) tests were measured. Diet and physical activity were assessed.
  
  
  RESULTS
  Subjects maintained their habitual dietary and exercise patterns over the study. Only CLA group showed a significant decrease in weight (74.43 ± 10.45 vs 73.54 ± 11.66 kg, p = 0.029) and waist circumference (91.45 ± 10.33 vs 90.65 ± 9.84 cm, p = 0.012) between baseline and end of the study. BMI and waist height ratio decreased (28.44 ± 1.08 vs 27.81 ± 1.43 kg/m2, p = 0.030 and 0.57 ± 0.05 vs 0.56 ± 0.04 p = 0.013 respectively) in CLA group at the end. CLA group experienced a reduction in total fat mass after 24 weeks (38.62 ± 5.02 vs 36.65 ± 5.64%, p = 0.035). No decrease was observed in Control group. HOMA index had no changes.
  
  
  CONCLUSIONS
  The consumption of skimmed milk enriched with 3g of a 1:1 mixture of c9-t11 and t10-c12 for 24 weeks led to a decrease in body weight and total fat mass in healthy, overweight subjects who maintained habitual diets and exercise patterns. No adverse effects were observed. Registered under ClinicalTrials.gov Identifier No. NCT01503047.
authors: Nutrition Department. Hospital La Paz Health Research Institute (IdiPaz). La Paz University Hospital. Madrid. Spain.. thabatakoester.investigacion@gmail.com.
authors: Bricia
authors: B
authors: López-Plaza
authors: Nutrition Department. Hospital La Paz Health Research Institute (IdiPaz). La Paz University Hospital. Madrid. Spain..
authors: Laura M
authors: LM
authors: Bermejo
authors: Nutrition Department. Hospital La Paz Health Research Institute (IdiPaz). La Paz University Hospital. Madrid. Spain.. thabatakoester.investigacion@gmail.com.
authors: Thabata
authors: T
authors: Koester Weber
authors: Laboratorio de Biología Molecular, Nutrición y Biotyecnología. University of the Balearic Islands and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), E-07122. Palma de Mallorca. Spain..
authors: Pilar
authors: P
authors: Parra
authors: Laboratorio de Biología Molecular, Nutrición y Biotyecnología. University of the Balearic Islands and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), E-07122. Palma de Mallorca. Spain..
authors: Francisca
authors: F
authors: Serra
authors: Nutrition Department. Corporación Alimentaria Peña Santa, SA. (CAPSA). Granda-Siero. Asturias. Spain..
authors: Marta
authors: M
authors: Hernández
authors: Nutrition Department. Hospital La Paz Health Research Institute (IdiPaz). La Paz University Hospital. Madrid. Spain..
authors: Samara
authors: S
authors: Palma Milla
authors: Nutrition Department. Hospital La Paz Health Research Institute (IdiPaz). La Paz University Hospital. Madrid. Spain..
authors: Carmen
authors: C
authors: Gómez-Candela
mesh_terms: D000328:Adult; D000818:Animals; D001835:Body Weight; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008892:Milk; D050177:Overweight / Q000178:diet therapy*; D011446:Prospective Studies
chemical_list: D044243:Linoleic Acids, Conjugated