title: Preparation, characterization and pulmonary pharmacokinetics of xyloglucan microspheres as dry powder inhalation.
abstract: The purpose of the present investigation was to prepare microspheres using xyloglucan as the polymer and to evaluate them for pulmonary delivery of Montelucast. Xyloglucan microspheres were prepared using spray-drying technique employing lactose monohydrate as carrier for dry powder inhalation. The formulation of microspheres was optimized using response surface methodology. Multiple response surface simultaneous optimizations using desirability approach were use to find optimal formulation. In vitro characterization of optimized microsphere formulation demonstrates its suitability as dry powder inhalation. It found to provide high and prolonged drug concentration within lungs after pulmonary administration in animal model.
authors: R.C. Patel Institute of Pharmaceutical Education and Research Shirpur, Dist Dhule, India. Electronic address: hsmahajan@rediffmail.com.
authors: Hitendra S
authors: HS
authors: Mahajan
authors: R.C. Patel Institute of Pharmaceutical Education and Research Shirpur, Dist Dhule, India.
authors: Sadanand A
authors: SA
authors: Gundare
mesh_terms: D000085:Acetates / Q000008:administration & dosage*; D000280:Administration, Inhalation; D000818:Animals; D002152:Calorimetry, Differential Scanning; D003521:Cyclopropanes; D005936:Glucans / Q000008:administration & dosage*; D008168:Lung; D008297:Male; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011208:Powders; D011804:Quinolines / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013440:Sulfides; D014990:Xylans / Q000008:administration & dosage*
chemical_list: D000085:Acetates; D003521:Cyclopropanes; D005936:Glucans; D011208:Powders; D011804:Quinolines; D013440:Sulfides; D014990:Xylans; C029353:xyloglucan; C093875:montelukast
keywords: Microspheres; Mucoadhesion; Pulmonary; Spray drying; Xyloglucan