title: The roles of transforming growth factor-β, Wnt, Notch and hypoxia on liver progenitor cells in primary liver tumours (Review).
abstract: Primary liver tumours have a high incidence and mortality. The most important forms are hepatocellular carcinoma and intrahepatic cholangiocarcinoma, both can occur together in the mixed phenotype hepatocellular-cholangiocarcinoma. Liver progenitor cells (LPCs) are bipotential stem cells activated in case of severe liver damage and are capable of forming both cholangiocytes and hepatocytes. Possibly, alterations in Wnt, transforming growth factor-β, Notch and hypoxia pathways in these LPCs can cause them to give rise to cancer stem cells, capable of driving tumourigenesis. In this review, we summarize and discuss current knowledge on the role of these pathways in LPC activation and differentiation during hepatocarcinogenesis.
authors: Department of Gastroenterology and Hepatology, 1K12, Ghent University Hospital, 9000 Gent, Belgium.
authors: Eliene
authors: E
authors: Bogaerts
authors: Department of Medical Biochemistry and Microbiology, Uppsala University, 751 23 Uppsala, Sweden.
authors: Femke
authors: F
authors: Heindryckx
authors: Department of Gastroenterology and Hepatology, 1K12, Ghent University Hospital, 9000 Gent, Belgium.
authors: Yves-Paul
authors: YP
authors: Vandewynckel
authors: Department of Cell Biology, Liver Cell Biology Lab, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
authors: Leo A
authors: LA
authors: Van Grunsven
authors: Department of Gastroenterology and Hepatology, 1K12, Ghent University Hospital, 9000 Gent, Belgium.
authors: Hans
authors: H
authors: Van Vlierberghe
mesh_terms: D001650:Bile Duct Neoplasms / Q000473:pathology; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000473:pathology; D002454:Cell Differentiation; D015687:Cell Hypoxia / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D018281:Cholangiocarcinoma / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology; D051880:Receptors, Notch / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000473:pathology*; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D060449:Wnt Signaling Pathway
chemical_list: D051880:Receptors, Notch; D016212:Transforming Growth Factor beta; D051153:Wnt Proteins