title: Assessment of 3-epi-25-OH-D₃ in preterm and full term infant samples and its relationship to demographic, anthropometric and biochemical determinants.
abstract: OBJECTIVE
  We aim to determine 3-epi-25-OH-D₃ in 155 leftover infant samples (<12 months) and its relationship with demographic, anthropometric and biochemical markers.
  
  
  METHODS
  Samples were randomly collected and assessed for 3-epi-25-OH-D3 by HPLC. Biochemical data were recorded, if available, including C-reactive protein, calcium, liver and renal markers. Season of birth, gestational age (pre-term vs full-term), weight and height were recorded for infants <1 month.
  
  
  RESULTS
  3-Epi-25-OH-D₃ was quantified in 97% of the samples. Serum levels of the epimer increased at the end of the pregnancy and decreased over the first year of life. 3-Epi-25-OH-D₃ was negatively associated with bilirubin and C-reactive protein but unrelated to gestational age, season, age after delivery, height and weight, and calcemia or renal function.
  
  
  CONCLUSIONS
  Based on the present data, both liver function and acute phase reactants should be considered when measuring 3-epi-25-OH-D₃ and assessing vitamin D status in infants.
authors: Unidad de Vitaminas, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain; Servicio de Bioquímica Clínica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain. Electronic address: fgranado.hpth@salud.madrid.org.
authors: F
authors: F
authors: Granado-Lorencio
authors: Servicio de Bioquímica Clínica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
authors: L Muñoz
authors: LM
authors: Garcia-Heras
authors: Unidad de Vitaminas, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain; Servicio de Bioquímica Clínica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
authors: I
authors: I
authors: Blanco-Navarro
authors: Unidad de Vitaminas, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.
authors: B
authors: B
authors: Pérez-Sacristán
mesh_terms: D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D002112:Calcifediol / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D012621:Seasons
chemical_list: D015415:Biomarkers; D002112:Calcifediol
keywords: 3-Epi-25-hydroxyvitamin D(3); Infants; Vitamin D status