title: Hepatoprotective effects of apple polyphenol extract on aluminum-induced liver oxidative stress in the rat.
abstract: This study was undertaken to determine the effectiveness of apple (Ralls) polyphenol extract (APE) in modulating aluminum chloride (AlCl3) induced hepatotoxicity in rats. The rats were distributed among 4 groups and fed different diets with or without AlCl3 (171.8 mg Al·kg(-1)·day(-1)) and APE (200 mg·kg(-1)·day(-1)) for 10 weeks. The activities of superoxide dismutase and catalase as well as the levels of glutathione and ATP synthesis were decreased by comparison with the control, while the activities of transaminases in serum, the levels of Al, and ATP hydrolysis were increased significantly in the liver of the Al-treated group. Furthermore, abnormal changes in the histological structure of the liver were observed in the Al-treated group. However, these toxic effects of Al were significantly reduced when the rats were fed diets supplemented with APE. This suggests that APE plays a role in the reduction of the toxic effects from Al in rats.
authors: a College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, People's Republic of China.
authors: Dai
authors: D
authors: Cheng
authors: Chunqiu
authors: C
authors: Zhu
authors: Cuntang
authors: C
authors: Wang
authors: Huiling
authors: H
authors: Xu
authors: Jiankang
authors: J
authors: Cao
authors: Weibo
authors: W
authors: Jiang
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D002712:Chlorides / Q000633:toxicity*; D002726:Chlorogenic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D009336:Necrosis; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013634:Tannins / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D017607:Aluminum Compounds; D002712:Chlorides; D005419:Flavonoids; D013634:Tannins; C526219:apple polyphenol extract; D002726:Chlorogenic Acid; D000077410:Aluminum Chloride