title: [Sleep disorders and quality of life in refractory partial epilepsy: results of the SLEEP study].
abstract: BACKGROUND
  Sleep disorders are frequent among patients with epilepsy and are correlated with a poorer quality of life.
  
  
  OBJECTIVE
  To evaluate the prevalence of sleep disorders in patients with refractory and non-refractory focal epilepsy, and to explore the influence of these alterations on the quality of life of these patients.
  
  
  METHODS
  An epidemiological, controlled, cross-sectional study was conducted in 150 outpatient neurology services. Patients who had been treated with two antiepileptic drugs since the onset of the disease (18-55 years) were recruited for the study.
  
  
  RESULTS
  The sample included 237 patients with non-refractory focal epilepsy and 264 patients with refractory focal epilepsy. Twenty-two per cent of the non-refractory epilepsy group and 45% of the group with refractory epilepsy (p < 0.0001) suffered from some sleep disorder. The patients with refractory epilepsy had a poorer quality of life (p < 0.001) as measured with the quality of life questionnaire QOLIE-10. A positive significant correlation was observed between quality of life and quality of sleep, in both chronic insomnia (r = 0.65; p < 0.0001) and excessive daytime sleepiness (r = 0.43; p < 0.0001).
  
  
  CONCLUSIONS
  Sleep disorders are more frequent in refractory than in non-refractory epilepsy, and affect the patients' quality of life.
authors: Hospital Clinico San Carlos, 28040 Madrid, Espana.
authors: Irene
authors: I
authors: García-Morales
authors: Antonio
authors: A
authors: Gil-Nagel
authors: Jesús
authors: J
authors: de Rosendo
authors: Alberto
authors: A
authors: Torres-Falcón
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001007:Anxiety / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D001930:Brain Injuries / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003863:Depression / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D004351:Drug Resistance; D004828:Epilepsies, Partial / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011788:Quality of Life; D012720:Severity of Illness Index; D020919:Sleep Disorders, Intrinsic / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology / Q000523:psychology; D011795:Surveys and Questionnaires
chemical_list: D000927:Anticonvulsants; D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs