title: The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.
abstract: Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates diverse cellular processes, such as development, reprogramming, differentiation, and proliferation. In regards to these processes, studies of Dot1/DOT1L-dependent H3K79 methylation have mainly focused on the transcriptional regulation of specific genes. Although the gene transcription mediated by Dot1/DOT1L during the cell cycle is not fully understood, H3K79 methylation plays a critical role in the progression of G 1 phase, S phase, mitosis, and meiosis. This modification may contribute to the chromatin structure that controls gene expression, replication initiation, DNA damage response, microtubule reorganization, chromosome segregation, and heterochromatin formation. Overall, Dot1/DOT1L is required to maintain genomic and chromosomal stability. This review summarizes the several functions of Dot1/DOT1L and highlights its role in cell cycle regulation.
authors: Department of Pharmacology; School of Medicine; Kyung Hee University; Seoul, Republic of Korea; Department of Biomedical Science; Graduate School; Kyung Hee University; Seoul, Republic of Korea.
authors: Wootae
authors: W
authors: Kim
authors: Department of Pharmacology; School of Medicine; Kyung Hee University; Seoul, Republic of Korea; Department of Biomedical Science; Graduate School; Kyung Hee University; Seoul, Republic of Korea.
authors: Minji
authors: M
authors: Choi
authors: Department of Pharmacology; School of Medicine; Kyung Hee University; Seoul, Republic of Korea; Department of Biomedical Science; Graduate School; Kyung Hee University; Seoul, Republic of Korea.
authors: Ja-Eun
authors: JE
authors: Kim
mesh_terms: D000818:Animals; D002453:Cell Cycle; D065150:Cellular Reprogramming; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D011495:Histone-Lysine N-Methyltransferase; D006657:Histones / Q000378:metabolism; D006801:Humans; D008239:Lysine / Q000378:metabolism; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology
chemical_list: D002843:Chromatin; D006657:Histones; C473477:DOT1L protein, human; D008780:Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; D008239:Lysine
keywords: DOT1L; H3K79; cell cycle; differentiation; histone methyltransferase; meiosis; mitosis; proliferation; replication; senescence