title: Elevated aurora kinase a protein expression in diabetic skin tissue.
abstract: BACKGROUND
  Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue.
  
  
  METHODS
  Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens.
  
  
  RESULTS
  Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining.
  
  
  CONCLUSIONS
  Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
authors: Department of Dermatology, Soonchunhyang University College of Medicine, Seoul, Korea.
authors: Moon Kyun
authors: MK
authors: Cho
authors: Department of Dermatology, Soonchunhyang University College of Medicine, Seoul, Korea.
authors: Je Min
authors: JM
authors: An
authors: Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Seoul, Korea.
authors: Chul Han
authors: CH
authors: Kim
authors: Department of Plastic and Reconstructive Surgery, Soonchunhyang University College of Medicine, Seoul, Korea.
authors: Sang Gue
authors: SG
authors: Kang
keywords: Diabetes mellitus; Skin