title: Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches.
abstract: Escherichia coli cyclic-AMP receptor protein (CRP) represents one of the paradigms of bacterial gene regulation. Yet despite decades of intensive study, new information continues to emerge that prompts reassessment of this classic regulatory system. Moreover, in recent years CRPs from several other bacterial species have been characterized, allowing the general applicability of the CRP paradigm to be tested. Here the properties of the E. coli, Mycobacterium tuberculosis and Pseudomonas putida CRPs are considered in the context of the ecological niches occupied by these bacteria. It appears that the cyclic-AMP-CRP regulatory system has been adapted to respond to distinct external and internal inputs across a broad sensitivity range that is, at least in part, determined by bacterial lifestyles.
authors: The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK. Electronic address: jeff.green@sheffield.ac.uk.
authors: Jeffrey
authors: J
authors: Green
authors: The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
authors: Melanie R
authors: MR
authors: Stapleton
authors: The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
authors: Laura J
authors: LJ
authors: Smith
authors: The Krebs Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield S10 2TN, UK.
authors: Peter J
authors: PJ
authors: Artymiuk
authors: Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
authors: Christina
authors: C
authors: Kahramanoglou
authors: Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
authors: Debbie M
authors: DM
authors: Hunt
authors: Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
authors: Roger S
authors: RS
authors: Buxton
mesh_terms: D000242:Cyclic AMP / Q000378:metabolism*; D002373:Cyclic AMP Receptor Protein / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D016958:Pseudomonas putida / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D013312:Stress, Physiological
chemical_list: D002373:Cyclic AMP Receptor Protein; D000242:Cyclic AMP