title: In vivo investigation of calcium phosphate coatings on Ti6-Al-4V alloy substrates using lactic acid - sodium lactate buffered synthetic body fluid.
abstract: OBJECTIVE
  The aim of this study was to evaluate the mode of failure and biomechanical characteristics of Ti-6Al-4V anchors biomimetically coated with calcium phosphate (CaP) for soft tissue fixation to bone in an animal model.
  
  
  METHODS
  The current study included 14 adult New Zealand white rabbits equally divided into two groups. Calcium phosphate-coated Ti-6Al-4V anchors were used in the test group and non-coated Ti-6Al-4V anchors in the control group. A new approach was applied to synthesize the CaP coatings via the biomimetic growth in the Lac-SBF containing Ca(2+) and PO4(3-) ions, Na-lactate and lactic acid (HL). Titanium anchors were implanted into the right tibia, followed by biomechanical tensile strength tests. Histological studies were carried out after removal of anchors (bone-implant surface).
  
  
  RESULTS
  The CaP-coated Ti-6Al-4V anchors had significantly higher tensile strength (p=0.003) and displacement values (p=0.004) than the non-coated anchors. Control group scores were higher than those of the test group (14 and 9, respectively) in tensile strength tests.
  
  
  CONCLUSIONS
  The new CaP coating can be used in orthopedic surgery as catalyzer to improve bone ingrowth. We believe that our research will form a model for further research on biomimetic coatings on Ti-6Al-4V substrates.
authors: Department of Orthopedics and Traumatology, Faculty of Medicine, Dokuz Eylül University, Izmir, Turkey.
authors: Hasan
authors: H
authors: Havitçioğlu
authors: Berivan
authors: B
authors: Ceçen
authors: Ahmet
authors: A
authors: Pasinli
authors: Mithat
authors: M
authors: Yüksel
authors: Ibrahim
authors: I
authors: Aydin
authors: Hasan
authors: H
authors: Yildiz
mesh_terms: D000497:Alloys; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001826:Body Fluids; D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004195:Disease Models, Animal; D017886:Durapatite / Q000737:chemistry; D020007:Implants, Experimental; D019344:Lactic Acid; D008422:Materials Testing / Q000379:methods; D011817:Rabbits; D019354:Sodium Lactate; D013718:Tensile Strength; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; C031462:titanium alloy (TiAl6V4); D019344:Lactic Acid; D017886:Durapatite; C020243:calcium phosphate; D014025:Titanium; D019354:Sodium Lactate