title: Value of preoperative inflammation-based prognostic scores in predicting overall survival and disease-free survival in patients with gastric cancer.
abstract: BACKGROUND
  This study was designed to identify which are the best preoperative inflammation-based prognostic scores in terms of overall survival (OS) and disease-free survival (DFS) in patients with gastric cancer.
  
  
  METHODS
  Between January 2004 and January 2013, 102 consecutive patients underwent resection for gastric cancer at S. Andrea Hospital, "La Sapienza", University of Rome. Their records were retrospectively reviewed.
  
  
  RESULTS
  After a median follow up of 40.8 months (8-107 months), patients' 1-, 3-, and 5-year OS rates were 88, 72, and 59 %, respectively. After R0 resection, the 1-, 3-, and 5-year DFS rates were 93, 74, and 56 %, respectively. A multivariate analysis of the significant variables showed that only the modified Glasgow prognostic scores (p < 0.001) and PI (p < 0.001) were independently associated with OS. Regarding DFS, multivariate analysis of the significant variables showed that the modified Glasgow prognostic score (p = 0.002) and prognostic index (p < 0.001) were independently associated with DFS.
  
  
  CONCLUSIONS
  The results of this study show that modified Glasgow prognostic score and prognostic index are independent predictors of OS and DFS in patients with gastric cancer.
authors: Third Division of General Surgery, Sant'Andrea Hospital, University of Rome "La Sapienza", Rome, Italy, paolo_aurello@yahoo.it.
authors: Paolo
authors: P
authors: Aurello
authors: Simone Maria
authors: SM
authors: Tierno
authors: Giammauro
authors: G
authors: Berardi
authors: Federico
authors: F
authors: Tomassini
authors: Paolo
authors: P
authors: Magistri
authors: Francesco
authors: F
authors: D'Angelo
authors: Giovanni
authors: G
authors: Ramacciato
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D009504:Neutrophils; D010976:Platelet Count; D011237:Predictive Value of Tests; D011300:Preoperative Care; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate
chemical_list: D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D012709:Serum Albumin; D002097:C-Reactive Protein