title: Evaluation of the effects of methotrexate released from polymeric implants in solid Ehrlich tumor.
abstract: In this study, the effects of the controlled and sustained release of methotrexate from poly(ɛ-caprolactone) implants were evaluated in the solid Ehrlich tumor. The drug locally leached from the implantable devices was capable of reducing the tumor growth and the necrotic areas of the tumor site. Furthermore, the methotrexate exerted its anti-tumor effect probably by the recruitment of neutrophils at the tumor site, which assisted in modulating the growth of the tumor. The polymeric implants containing methotrexate could be a chemotherapic alternative to treat locally solid tumors with lower systemic side effects.
authors: School of Pharmacy, Federal University of São João del-Rei, Rua Sebastião Gonçalves Coelho, 400, Chanadour, Divinópolis, CEP, 35501-296, Minas Gerais, Brazil.
authors: Adriana
authors: A
authors: de Fátima Pereira
authors: School of Pharmacy, Federal University of São João del-Rei, Rua Sebastião Gonçalves Coelho, 400, Chanadour, Divinópolis, CEP, 35501-296, Minas Gerais, Brazil.
authors: Vivian
authors: V
authors: Mara da Costa
authors: School of Pharmacy, Federal University of São João del-Rei, Rua Sebastião Gonçalves Coelho, 400, Chanadour, Divinópolis, CEP, 35501-296, Minas Gerais, Brazil.
authors: Millene
authors: M
authors: Cristina Magalhães Santos
authors: Rosy Iara
authors: RI
authors: Maciel de A Ribeiro
authors: Ana
authors: A
authors: Gabriela Silva
authors: School of Pharmacy, Federal University of São João del-Rei, Rua Sebastião Gonçalves Coelho, 400, Chanadour, Divinópolis, CEP, 35501-296, Minas Gerais, Brazil.
authors: Flávia
authors: F
authors: Carmo Horta Pinto
authors: Paula
authors: P
authors: Vieira Teixeira Vidigal
authors: School of Pharmacy, Federal University of São João del-Rei, Rua Sebastião Gonçalves Coelho, 400, Chanadour, Divinópolis, CEP, 35501-296, Minas Gerais, Brazil. Electronic address: giselersilva@ufsj.edu.br.
authors: Gisele
authors: G
authors: Rodrigues Da Silva
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry*; D004343:Drug Implants; D005260:Female; D007150:Immunohistochemistry; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D051379:Mice; D011091:Polyesters / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry*
chemical_list: D000964:Antimetabolites, Antineoplastic; D004337:Drug Carriers; D004343:Drug Implants; D011091:Polyesters; C016240:polycaprolactone; D008727:Methotrexate
keywords: Drug delivery systems; Polymeric implants containing methotrexate; Solid Ehrlich tumor