title: A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.
abstract: High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activities, such as inducing chemotaxis or the transcription of cytokines and chemokines, via the interaction with different receptors. The different HMGB1 redox forms can be identified by mass spectrometry in body fluids of patients and may hold promise as biomarkers. We propose here a systematic nomenclature of the different redox forms of HMGB1 and related proteins, to replace the conflicting names used so far by different laboratories.
authors: MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom.
authors: Daniel J
authors: DJ
authors: Antoine
authors: Department of Medicine, Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden.
authors: Helena Erlandsson
authors: HE
authors: Harris
authors: Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
authors: Ulf
authors: U
authors: Andersson
authors: Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, United States of America.
authors: Kevin J
authors: KJ
authors: Tracey
authors: San Raffaele University and Scientific Institute, Milan, Italy.
authors: Marco E
authors: ME
authors: Bianchi
mesh_terms: D001665:Binding Sites; D015415:Biomarkers; D003545:Cysteine / Q000737:chemistry*; D024243:HMGB1 Protein / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D009626:Terminology as Topic
chemical_list: D015415:Biomarkers; D024243:HMGB1 Protein; D003545:Cysteine