title: Plasma cytokine concentrations in dogs with a congenital portosystemic shunt.
abstract: Congenital portosystemic shunts (cPSS) are a well-recognised vascular anomaly in dogs. Recent studies have shown an association between inflammation and hepatic encephalopathy (HE), which is a common clinical syndrome in dogs with a cPSS. Pro-inflammatory cytokines such as interleukin (IL)-6 and tumour necrosis factor (TNF)-α are frequently increased in the plasma of human patients with liver disease and have been implicated in the development of HE. In the current study, plasma concentrations of IL-2, IL-6, IL-8 and TNF-α were measured using a multiplex electrochemiluminescence immunoassay in 36 dogs with a cPSS and compared to 25 healthy dogs. There were no significant differences in plasma IL-2, IL-8 and TNF-α concentrations between the two groups; however, plasma concentrations of IL-6 were significantly higher in dogs with a cPSS compared to healthy dogs (P=0.02).
authors: Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom.
authors: Scott
authors: S
authors: Kilpatrick
authors: Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom; Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom.
authors: Adam G
authors: AG
authors: Gow
authors: Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Cambridgeshire CB8 0UH, United Kingdom.
authors: Rob D
authors: RD
authors: Foale
authors: Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Cambridgeshire CB8 0UH, United Kingdom.
authors: Simon W
authors: SW
authors: Tappin
authors: Tay Valley Veterinary Centre, Perth PH2 0PA, United Kingdom.
authors: Harvey
authors: H
authors: Carruthers
authors: Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom.
authors: Nicola
authors: N
authors: Reed
authors: Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom.
authors: Donald A
authors: DA
authors: Yool
authors: Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom.
authors: Samantha
authors: S
authors: Woods
authors: Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom.
authors: Ana I
authors: AI
authors: Marques
authors: UCL Institute of Hepatology, Royal Free Hospital, Upper Third Floor, UCL Medical School, Pond Street, London NW3 2QG, United Kingdom.
authors: Rajiv
authors: R
authors: Jalan
authors: Royal (Dick) School of Veterinary Studies, Division of Veterinary Clinical Sciences, Hospital for Small Animals, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom; Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Midlothian EH25 9RG, United Kingdom. Electronic address: Richard.mellanby@ed.ac.uk.
authors: Richard J
authors: RJ
authors: Mellanby
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood; D004283:Dog Diseases / Q000175:diagnosis*; D004285:Dogs / Q000002:abnormalities* / Q000378:metabolism*; D005260:Female; D007118:Immunoassay / Q000662:veterinary; D008107:Liver Diseases / Q000175:diagnosis / Q000662:veterinary*; D008163:Luminescent Measurements / Q000662:veterinary; D008297:Male; D011168:Portal System / Q000002:abnormalities*
chemical_list: D016207:Cytokines
keywords: Congenital portosystemic shunt; Dog; Hepatic encephalopathy; Interleukin-6