title: Sirtuin-3 (SIRT3), a therapeutic target with oncogenic and tumor-suppressive function in cancer.
abstract: Sirtuin-3 (SIRT3), a major mitochondria NAD+-dependent deacetylase, may target mitochondrial proteins for lysine deacetylation and also regulate cellular functions. And, SIRT3 is an emerging instrumental regulator of the mitochondrial adaptive response to stress, such as metabolic reprogramming and antioxidant defense mechanisms. Accumulating evidence has recently demonstrated that SIRT3 may function as either oncogene or tumor suppressor on influencing cell death by targeting a series of key modulators and their relevant pathways in cancer. Thus, in this review, we present the structure, transcriptional regulation, and posttranslational modifications of SIRT3. Subsequently, we focus on highlighting the Janus role of SIRT3 with oncogenic or tumor-suppressive function in cancer, which may provide more new clues for exploring SIRT3 as a therapeutic target for drug discovery.
authors: State Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Y
authors: Y
authors: Chen
authors: College of Life Sciences, Sichuan University, Chengdu 610064, China.
authors: L L
authors: LL
authors: Fu
authors: 1] State Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China [2] College of Life Sciences, Sichuan University, Chengdu 610064, China.
authors: X
authors: X
authors: Wen
authors: Analytical & Testing Center, Sichuan University, Chengdu 610064, China.
authors: X Y
authors: XY
authors: Wang
authors: State Key Laboratory of Biotherapy, Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: J
authors: J
authors: Liu
authors: Department of Pharmacology and The Penn State Cancer Institute, The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania, USA.
authors: Y
authors: Y
authors: Cheng
authors: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors: J
authors: J
authors: Huang
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000235:genetics; D056566:Sirtuin 3 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D025521:Tumor Suppressor Proteins; D056566:Sirtuin 3