title: Bilineal T lymphoblastic and myeloid blast transformation in chronic myeloid leukemia with TP53 mutation-an uncommon presentation in adults.
abstract: Bilineal blast transformation of myeloid and T lymphoid type is a rare event in chronic myeloid leukemia. Here, we report a case in which an adult presented with high white cell counts and lymphadenopathy. Bone marrow studies confirmed the presence of 9 and 22 chromosomal translocation, and a diagnosis of chronic myeloid leukemia in chronic phase was made. Examination of a lymph node showed both myeloid and T lymphoblastoid blast crisis. Molecular studies demonstrated the presence of BCR-ABL fusion transcripts in both the myeloid and the T lymphoblastic component, indicating that the myeloid and T lymphoid blast crisis components shared common progenitors. TP53 deletion was demonstrated by fluorescence in situ hybridization.
authors: Department of Haematology, Singapore General Hospital, Singapore. ; Duke-NUS Graduate Medical School, Singapore.
authors: S
authors: S
authors: Krishnan
authors: Singhealth Tissue Repository, Singapore Health Services, Singapore.
authors: K
authors: K
authors: Sabai
authors: Department of Haematology, Singapore General Hospital, Singapore. ; Duke-NUS Graduate Medical School, Singapore.
authors: C
authors: C
authors: Chuah
authors: Department of Haematology, Singapore General Hospital, Singapore.
authors: S Y
authors: SY
authors: Tan
keywords: BCR-ABL; Chronic myeloid leukemia; T lymphoblastic lymphoma; TP53 mutation; blast transformation; myeloid sarcoma