title: Prognostic value of phospho-Akt in patients with non-small cell lung carcinoma: a meta-analysis.
abstract: Previous studies have been inconsistent with respect to the reported associations between phospho-Akt (p-Akt) overexpression and lung cancer prognosis. In this study, we conducted a systematic review and meta-analysis to assess the prognostic value of p-Akt in patients with non-small cell lung carcinoma (NSCLC). Relevant articles were identified by searching MEDLINE. Hazard risks (HRs) from individual studies were calculated and pooled by using a random-effect model, and heterogeneity and publication bias analyses were also performed. Finally, 18 studies comprising 2,353 patients were included in the meta-analysis. p-Akt overexpression was associated with worse survival in NSCLC patients, and the pooled HRs for all the studies was 1.38 (95% confidence interval [CI]: 1.11-1.70; p<0.01). After subgroup analysis, the association was strengthened in the surgery treatment group, with an HR of 1.44 (95% CI: 1.19-1.75; p<0.01), while in the tyrosine kinase inhibitors treatment group, the statistical significance disappeared (HR: 1.22, 95% CI: 0.70-2.14; p=0.48). The HR in cases of early stage disease (I-III) was 1.35 (95% CI: 1.08-1.69; p=0.04); however, in cases of late stage disease (III-IV), the association became non-significant (HR: 1.22, 95% CI: 0.64-2.33; p=0.54). Our results suggest that there was a significantly inverse association between p-Akt overexpression and the prognosis of NSCLC patients, and that this association appeared to be limited in early-stage patients who underwent surgery.
authors: Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, 310022, People's Republic of China; Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, China.
authors: Yang
authors: Y
authors: Yang
authors: Jialin
authors: J
authors: Luo
authors: Xiaoming
authors: X
authors: Zhai
authors: Zhiqin
authors: Z
authors: Fu
authors: Zhongzhu
authors: Z
authors: Tang
authors: Luying
authors: L
authors: Liu
authors: Ming
authors: M
authors: Chen
authors: Yuan
authors: Y
authors: Zhu
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology*; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology*; D051058:Oncogene Protein v-akt / Q000378:metabolism*; D010766:Phosphorylation; D011379:Prognosis
chemical_list: D051058:Oncogene Protein v-akt
keywords: lung cancer; meta-analysis; p-Akt; prognostic factor; survival