title: Phthalate levels in cord blood are associated with preterm delivery and fetal growth parameters in Chinese women.
abstract: Data concerning the effects of phthalate exposure on preterm delivery and fetal growth are limited in humans. In this paper, we assessed the relationship between 15 phthalate levels in cord blood and preterm delivery and fetal growth parameters in 207 Chinese women going into labor. Exposure to phthalates except DCHP was associated with gestational age reduction and preterm delivery (p<0.05). There were associations between phthalates and fetal growth parameters, many of which disappeared when analyses were adjusted for gestational age, especially in male infants (Only DEEP was associated with birth weight; DEP, DNHP, BBP, DNP with abdominal circumference; DEP, DBP, DCHP, DEHP with femur length in female infants. And DPP, DBEP was associated with birth length in male infants. p<0.05). This study indicates that prenatal exposure to phthalates is associated with younger gestational age and preterm delivery. Also, phthalate exposure may adversely affect fetal growth parameters via gestational age reduction and preterm delivery with a significant gender effect.
authors: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors: Yujing
authors: Y
authors: Huang
authors: Department of gynecology and obstetrics, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors: Junnan
authors: J
authors: Li
authors: Division of Endocrinology, Center for Translational Research in Inflammatory Diseases, Michael E. DeBakey VAMC/Baylor College of Medicine, Houston, Texas, United States of America.
authors: Jose M
authors: JM
authors: Garcia
authors: Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors: Hui
authors: H
authors: Lin
authors: Department of gynecology and obstetrics, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors: Yanzhou
authors: Y
authors: Wang
authors: Department of gynecology and obstetrics, Southwest Hospital, Third Military Medical University, Chongqing, China.
authors: Ping
authors: P
authors: Yan
authors: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors: Lingqiao
authors: L
authors: Wang
authors: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors: Yao
authors: Y
authors: Tan
authors: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors: Jiaohua
authors: J
authors: Luo
authors: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors: Zhiqun
authors: Z
authors: Qiu
authors: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China ; Division of Endocrinology, Center for Translational Research in Inflammatory Diseases, Michael E. DeBakey VAMC/Baylor College of Medicine, Houston, Texas, United States of America.
authors: Ji-an
authors: JA
authors: Chen
authors: Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors: Weiqun
authors: W
authors: Shu
mesh_terms: D044466:Asian People; D001724:Birth Weight; D002681:China; D004952:Esters / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D047109:Fetal Development; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010795:Phthalic Acids / Q000097:blood*; D037841:Pregnant People; D047928:Premature Birth / Q000097:blood*
chemical_list: D004952:Esters; D010795:Phthalic Acids; C032279:phthalic acid