title: Elevated serum levels of lysophosphatidic acid in patients with multiple sclerosis.
abstract: A plethora of studies have shown that lysophosphatidic acid (LPA) is involved both in inflammation and T cell apoptosis evasion. The aim of this study was to measure the concentrations of LPA in serum of patients with multiple sclerosis (MS). Twenty MS patients along with 20age-sex matched healthy individuals were recruited for this investigation. By employment of ELISA method, we demonstrated that MS patients had higher levels of LPA in serum than control group (P=0.006). This study is the first report of LPA elevation in MS disease.
authors: Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Mohammad
authors: M
authors: Balood
authors: Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Hamid
authors: H
authors: Zahednasab
authors: Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
authors: Bahaaddin
authors: B
authors: Siroos
authors: Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
authors: Seyed Alireza
authors: SA
authors: Mesbah-Namin
authors: Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran.
authors: Sara
authors: S
authors: Torbati
authors: Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: harirchm@sina.tums.ac.ir.
authors: Mohammad Hossein
authors: MH
authors: Harirchian
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008246:Lysophospholipids / Q000097:blood*; D008297:Male; D009103:Multiple Sclerosis / Q000097:blood*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood
chemical_list: D008246:Lysophospholipids; C032881:lysophosphatidic acid