title: Contrast-enhanced ultrasonograpic studies on pancreatic carcinoma with special reference to staining and muscular arterial vessels.
abstract: Comparative study of contrast-enhanced ultrasonography (CE-US) and histopathology of surgically resected specimens in 13 patients with pancreatic carcinoma. A time intensity curve was used to determine the percentage brightness increase in cancerous and normal regions and the patients were divided into two groups, hyperperfusion, with a percentage brightness increase over 80% (n=6) and hypoperfusion, with an increase of less than 80% (n=7) on CE-US. The hyperperfusion group included well-differentiated tubular adenocarcinoma, adenosquamous cell carcinoma and acinar cell carcinoma, while all 7 patients in the hypoperfusion group had moderately differentiated tubular adenocarcinoma. Immunological staining (α-SMA and anti-CD34) of the resected specimens showed significantly higher microartery count (MAC) in the hyperperfusion group (p<0.005) than in the hypoperfusion group or normal pancreas. In the normal pancreas, the mean vessel diameter was significantly higher (over 100 μm) than in the hyperperfusion group (30 μm; p<0.005). It was concluded that a muscular arterial vessel density of less than 30 μm is an important factor in determining staining degree and carcinoma progression by CE-US in pancreatic carcinoma.
authors: Division of Gastroenterology Department of Medicine, Kurume University School of Medicine.
authors: Hideya
authors: H
authors: Suga
authors: Yoshinobu
authors: Y
authors: Okabe
authors: Osamu
authors: O
authors: Tsuruta
authors: Yoshiki
authors: Y
authors: Naito
authors: Hisafumi
authors: H
authors: Kinoshita
authors: Atsushi
authors: A
authors: Toyonaga
authors: Naofumi
authors: N
authors: Ono
authors: Kazuhiko
authors: K
authors: Oho
authors: Masamichi
authors: M
authors: Kojiro
authors: Michio
authors: M
authors: Sata
mesh_terms: D000199:Actins / Q000032:analysis; D000230:Adenocarcinoma / Q000098:blood supply / Q000000981:diagnostic imaging; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D001158:Arteries / Q000000981:diagnostic imaging / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000601:surgery; D018267:Carcinoma, Acinar Cell / Q000098:blood supply / Q000000981:diagnostic imaging; D018196:Carcinoma, Adenosquamous / Q000098:blood supply / Q000000981:diagnostic imaging; D003287:Contrast Media; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000737:chemistry / Q000000981:diagnostic imaging* / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000601:surgery; D011134:Polysaccharides; D011237:Predictive Value of Tests; D013194:Staining and Labeling; D014463:Ultrasonography
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508