title: Insulin-like growth factor binding protein-related protein 1 and cancer.
abstract: Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) belongs to the IGFBP family whose members have a conserved structural homology. It has a low affinity for IGFs and a high affinity for insulin, suggesting that IGFBP-rP1 may have a biological function distinct from other members of the family. IGFBP-rP1 is ubiquitously expressed in normal human tissues and has diverse biological functions, regulating cell proliferation, apoptosis and senescence; it may also have a key role in vascular biology. Increasing evidence suggests that IGFBP-rP1 acts as a tumor suppressor. It elicits its biological effects by both insulin/IGF-dependent and -independent mechanisms. This paper provides a brief overview of the structure and regulation of IGFBP-rP1 and its various biological functions in cancer, as well as the underlying molecular mechanisms.
authors: Department of Pathology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058 Zhejiang, China; Department of Clinical Laboratory, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Jinan 250012, China. Electronic address: zhushuzhen@zju.edu.cn.
authors: Shuzhen
authors: S
authors: Zhu
authors: Department of Pathology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058 Zhejiang, China. Electronic address: xfy@zju.edu.cn.
authors: Fangying
authors: F
authors: Xu
authors: Department of Pathology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058 Zhejiang, China. Electronic address: jing_zhang@zju.edu.cn.
authors: Jing
authors: J
authors: Zhang
authors: Department of Respiratory Diseases, Affiliated Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qingchundong Road, Hangzhou 310016, China. Electronic address: rwj@zju.edu.cn.
authors: Wenjing
authors: W
authors: Ruan
authors: Department of Pathology, Zhejiang University School of Medicine, 866 Yuhangtang Road, Hangzhou, 310058 Zhejiang, China. Electronic address: lmd@zju.edu.cn.
authors: Maode
authors: M
authors: Lai
mesh_terms: D000818:Animals; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000502:physiology
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1
keywords: Cancer; IGF; IGFBP-rP1