title: Direct effect of chlorine dioxide, zinc chloride and chlorhexidine solution on the gaseous volatile sulfur compounds.
abstract: OBJECTIVE
  This study focused on the ability of aqueous anti-volatile-sulfur-compound (VSC) solutions to eliminate gaseous VSCs by direct contact in a sealed space to describe possible mode of action of anti-VSC agents.
  
  
  METHODS
  Twenty milliliters of each experimental solution, 0.16% sodium chlorite, 0.25% zinc chloride, 0.1% chlorhexidine and distilled water, was injected into a Teflon bag containing mixed VSCs, hydrogen sulfide, methyl mercaptan and dimethyl sulfide and mixed vigorously for 30 s. The VSC concentration was measured by gas chromatography before, immediately after, 30 min and 60 min after mixing.
  
  
  RESULTS
  The sodium chlorite solution reduced the VSC concentration remarkably. After mixing, nearly all VSCs were eliminated immediately and no VSCs were detected at 30 and 60 min post-mixing. However, in the other solutions, the VSC concentration decreased by ∼30% immediately after mixing and there was no further decrease.
  
  
  CONCLUSIONS
  The results suggest that sodium chlorite solution has the effect of eliminating gaseous VSCs directly. This must be because it can release chlorine dioxide gas which can react directly with gaseous VSCs. In the case of other solutions that have been proved to be effective to reduce halitosis clinically, it can be proposed that their anti-VSC effect is less likely due to the direct chemical elimination of gaseous VSCs in the mouth.
authors: Department of Oral Medicine & Oral Diagnosis, School of Dentistry & Dental Research Institute, Seoul National University , Seoul , Korea (ROK).
authors: Ju-Sik
authors: JS
authors: Kim
authors: Ji-Woon
authors: JW
authors: Park
authors: Dae-Jung
authors: DJ
authors: Kim
authors: Young-Ku
authors: YK
authors: Kim
authors: Jeong-Yun
authors: JY
authors: Lee
mesh_terms: D002710:Chlorhexidine / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D017606:Chlorine Compounds / Q000737:chemistry*; D002849:Chromatography, Gas; D006209:Halitosis / Q000188:drug therapy; D006801:Humans; D006862:Hydrogen Sulfide / Q000737:chemistry; D008422:Materials Testing; D010087:Oxides / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013440:Sulfides / Q000737:chemistry; D013457:Sulfur Compounds / Q000737:chemistry*; D013997:Time Factors; D055549:Volatile Organic Compounds / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D002712:Chlorides; D017606:Chlorine Compounds; D010087:Oxides; D013438:Sulfhydryl Compounds; D013440:Sulfides; D013457:Sulfur Compounds; D055549:Volatile Organic Compounds; D017967:Zinc Compounds; C005231:methylmercaptan; C025109:chlorine dioxide; C016837:zinc chloride; C004784:dimethyl sulfide; D002710:Chlorhexidine; D006862:Hydrogen Sulfide; C001599:chlorite
keywords: bad breath; halitosis; mouthrinse; volatile sulfur compounds