title: EEG network connectivity changes in mild cognitive impairment - Preliminary results.
abstract: Resting state EEGs were compared between patients with amnestic subtype of mild cognitive impairment (aMCI) and matched elderly controls at two times over a one year period. The study aimed at investigating the role of functional connectivity between and within different brain regions in relation to the progression of cognitive deficit in MCI. The EEG was recorded in two sessions during eyes closed and eyes open resting conditions. Functional brain connectivity was investigated based on the measurement of phase synchronization in different frequency bands. Delta and theta synchronization characteristics indicated decreased level of local and large-scale connectivity in the patients within the frontal, between the frontal and temporal, and frontal and parietal brain areas which was more pronounced 1year later. As a consequence of opening the eyes connectivity in the alpha1 band within the parietal lobe decreased compared to the eyes closed condition but only in the control group. The lack of alpha1 band reactivity following eye opening could reliably differentiate patients from controls. Our preliminary results support the notion that the functional disconnection between distant brain areas is a characteristic feature of MCI, and may prove to be predictive in terms of the progression of this condition.
authors: Institute of Cognitive Neuroscience and Psychology, RCNS, HAS, Hungary; Department of Cognitive Science, Institute of Psychology, Eötvös Loránd University, Budapest, Hungary. Electronic address: toth.brigitta@ttk.mta.hu.
authors: Brigitta
authors: B
authors: Tóth
authors: Faculty of Information Technology, Pázmány Péter Catholic University, Budapest, Hungary.
authors: Bálint
authors: B
authors: File
authors: Institute of Cognitive Neuroscience and Psychology, RCNS, HAS, Hungary.
authors: Roland
authors: R
authors: Boha
authors: Institute of Cognitive Neuroscience and Psychology, RCNS, HAS, Hungary; Department of Cognitive Science, Institute of Psychology, Eötvös Loránd University, Budapest, Hungary.
authors: Zsófia
authors: Z
authors: Kardos
authors: Department of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors: Zoltán
authors: Z
authors: Hidasi
authors: Institute of Cognitive Neuroscience and Psychology, RCNS, HAS, Hungary.
authors: Zsófia Anna
authors: ZA
authors: Gaál
authors: Department of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors: Eva
authors: E
authors: Csibri
authors: Department of Psychiatry and Psychotherapy, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors: Pál
authors: P
authors: Salacz
authors: Department of Clinical Neurophysiology, VU University Medical Centre, Amsterdam, Netherlands.
authors: Cornelis Jan
authors: CJ
authors: Stam
authors: Institute of Cognitive Neuroscience and Psychology, RCNS, HAS, Hungary; Psychophysiology Unit, Institute of Psychology, Eötvös Loránd University, Budapest, Hungary.
authors: Márk
authors: M
authors: Molnár
keywords: EEG; Follow-up study; Functional connectivity; Mild cognitive impairment; Phase synchronization