title: [Expression of RAGE in Helicobacter pylori infested gastric biopsies].
abstract: BACKGROUND
  Inflammation is a common phenomenon present in gastric mucosa of patients infected with H. pylori. Activation of the RAGE/multiligand axis is thought to be a relevant factor in cancer-mediated inflammation. RAGE is a membrane receptor, belonging to the immunoglobulin family, and the over-expression of RAGE has been associated with increased invasiveness and metastasis generation in different types of cancer, including gastric cancer. Furthermore recent experiences show that the use of its soluble form (sRAGE) or silencing of the gene coding for this receptor could provide therapeutic benefits in cancer.
  
  
  OBJECTIVE
  To evaluate the immunohistochemical expression of RAGE, MUC-1, β-Catenin free and phosphorylated, Cyclin-D1 and GSK3 in gastric biopsy specimens infected with H. pylori.
  
  
  METHODS
  Immunohistochemical analysis was carried out in gastric biopsies from 138 patients: 55 with inflammatory injury (no atrophic gastritis), 42 with pre-cancerous conditions (atrophy or intestinal metaplasia) and 41 with dysplastic lesions or in situ adenocarcinoma.
  
  
  RESULTS
  There was a high rate of positive RAGE expression in the three groups of biopsies. Biopsies with dysplasia or in situ carcinoma had a significantly higher percentage of RAGE expression than the other groups of biopsies.
  
  
  CONCLUSIONS
  The increased RAGE expression reported in both dysplasia and incipient cancer support the role of the multiligand/RAGE axis in gastric carcinogenesis.
authors: Erik
authors: E
authors: Morales M
authors: Armando
authors: A
authors: Rojas R
authors: Valeria
authors: V
authors: Monasterio A
authors: Ileana
authors: I
authors: González B
authors: Ingrid
authors: I
authors: Figueroa C
authors: Belamiro
authors: B
authors: Manques M
authors: Jaqueline
authors: J
authors: Romero E
authors: Jorge
authors: J
authors: Llanos L
authors: Eliana
authors: E
authors: Valdés M
authors: Cecilia
authors: C
authors: Cofré L
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D019938:Cyclin D1 / Q000032:analysis; D005260:Female; D005753:Gastric Mucosa / Q000737:chemistry* / Q000382:microbiology; D038362:Glycogen Synthase Kinase 3 / Q000032:analysis; D000071679:Glycogen Synthase Kinase 3 beta; D016481:Helicobacter Infections / Q000378:metabolism; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D011230:Precancerous Conditions / Q000737:chemistry*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry*; D055815:Young Adult; D051176:beta Catenin / Q000032:analysis
chemical_list: D015415:Biomarkers; C060192:MUC1 protein, human; D018396:Mucin-1; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D051176:beta Catenin; D019938:Cyclin D1; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3