title: Circulating concentrations of C-Peptide and colorectal adenoma.
abstract: Hyperinsulinemia may increase the risk of colorectal neoplasia because of its mitogenic and antiapoptotic properties, which have a growth-promoting effect. We examined the association between circulating concentrations of C-peptide, a biomarker of insulin secretion, and colorectal adenoma prevalence in a case-control study of Korean adults. A total of 364 participants (112 cases and 252 controls) were included. Participants who underwent a colonoscopy completed questionnaires and provided blood samples. We used multivariate logistic regression models to obtain odds ratios (ORs) and 95% confidence intervals (CIs) for colorectal adenoma. Circulating concentrations of C-peptide were not associated with colorectal adenoma; the multivariate OR (95% CI) was 0.95 (0.51-1.75) comparing the highest tertile with the lowest tertile (p for trend = 0.91). When we used a conditional logistic regression model by fasting status and sex matching, there was still no association (OR = 0.92; 95% CI = 0.43-1.99) when comparing the highest tertile with the lowest tertile. We observed no association between circulating concentrations of C-peptide and colorectal adenoma prevalence in Korean adults.
authors: Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.
authors: Yoon Ji
authors: YJ
authors: Choi
authors: Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.
authors: Young Ha
authors: YH
authors: Kim
authors: Department of Pathology, Daegu Catholic University Medical Center, Daegu 705-718, South Korea.
authors: Chang Ho
authors: CH
authors: Cho
authors: Department of Family Medicine, Daegu Catholic University Medical Center, Daegu 705-718, South Korea.
authors: Sung Hi
authors: SH
authors: Kim
authors: Department of Food and Nutrition, Sookmyung Women's University, Seoul 140-742, South Korea.
authors: Jung Eun
authors: JE
authors: Lee
keywords: C-peptide; Colorectal adenoma; Hyperinsulinemia