title: Prognostic significance of p53, mTOR, c-Met, IGF-1R, and HSP70 overexpression after the resection of hepatocellular carcinoma.
abstract: OBJECTIVE
  The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival.
  
  
  METHODS
  We analyzed the immunohistochemical expression of p53, mammalian target of rapamycin (mTOR), c-Met, and insulin-like growth factor 1 receptor (IGF-1R) heat shock protein 70 (HSP70) with the clinicopathologic features of 83 HCCs.
  
  
  RESULTS
  p53 expression was higher in the male patients with undifferentiated histological tumor grades, cirrhosis, and portal vein invasion. High 48 c-Met expression correlated with cirrhosis, and high mTOR expression correlated with the tumor grade and cirrhosis. High IGF-1R expression correlated with the tumor grade and cirrhosis. A multivariate analysis identified a significant relationship between the high expression of p53, tumor grade, and portal vein invasion. In addition, a high expression of mTOR was related to tumor grade and cirrhosis, and a high expression of HSP70 was related to portal vein invasion in a multivariate analysis. The Kaplan-Meier survival curve for patients with high versus low Edmondson grades and p53 expression was statistically significant.
  
  
  CONCLUSIONS
  p53, mTOR, and IGF-1R expression correlated with the Edmondson tumor grade in a univariate analysis, while p53 and mTOR correlated with the Edmondson tumor grade in a multivariate analysis. In addition, the tumor grade was found to predict survival. p53 was primarily related to the clinicopathologic features compared to other markers, and it is a poor prognostic factor of survival.
authors: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
authors: Gu Hyum
authors: GH
authors: Kang
authors: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
authors: Byung Seok
authors: BS
authors: Lee
authors: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
authors: Eaum Seok
authors: ES
authors: Lee
authors: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
authors: Seok Hyun
authors: SH
authors: Kim
authors: Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
authors: Heon Young
authors: HY
authors: Lee
authors: Department of Pathology, Chungnam National University School of Medicine, Daejeon, Korea.
authors: Dae Young
authors: DY
authors: Kang
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism; D017526:Receptor, IGF Type 1 / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D018840:HSP70 Heat-Shock Proteins; D016159:Tumor Suppressor Protein p53; D019859:Proto-Oncogene Proteins c-met; D017526:Receptor, IGF Type 1; D058570:TOR Serine-Threonine Kinases
keywords: Carcinoma, hepatocellular; Receptor, IGF type 1; c-Met; mTOR; p53