title: Synthesis and applications of polyacrylamide grafted agar as a matrix for controlled drug release of 5-ASA.
abstract: Agar has been modified by microwave assisted grafting with acrylamide monomer, resulting in poly acrylamide grafted agar (Ag-g-PAM). The synthesized grades of Ag-g-PAM were characterized by standard physico-chemical characterization techniques (FTIR spectroscopy, elemental analysis, scanning electron microscopy (SEM)) to ascertain the intended grafting. The synthesized graft copolymer (Ag-g-PAM) has been investigated (in vitro) for controlled and colon targeted release of 5-amino salicylic acid (5-ASA).
authors: Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi 835 215, Jharkhand, India.
authors: G
authors: G
authors: Usha Rani
authors: Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi 835 215, Jharkhand, India.
authors: Ananda Kumar
authors: AK
authors: Konreddy
authors: Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi 835 215, Jharkhand, India. Electronic address: sumitmishra1@gmail.com.
authors: Sumit
authors: S
authors: Mishra
authors: Department of Applied Chemistry, Birla Institute of Technology, Mesra, Ranchi 835 215, Jharkhand, India.
authors: Gautam
authors: G
authors: Sen
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000362:Agar / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D006873:Hydroquinones / Q000737:chemistry; D007700:Kinetics; D019804:Mesalamine / Q000737:chemistry*; D014783:Viscosity; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000362:Agar; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006873:Hydroquinones; D019804:Mesalamine; D000099166:Polyacrylamides; C031927:hydroquinone
keywords: 5-Amino salicylic acid; Agar; Controlled drug release; Microwave assisted synthesis; Polyacrylamide grafted agar