title: Antitumor and immunomodulatory effects of a water-soluble polysaccharide from Lilii Bulbus in mice.
abstract: Lilii Bulbus is a popular folk medicine in the worldwide and has attracted great attention due to its bioactivity against respiratory system diseases (include lung cancers). This study was the first report providing in vivo evidences of antitumor potential of the bioactive polysaccharide from Lilii Bulbus. One major fraction (LBP-1) was obtained by purifying the crude polysaccharides extracted from Lilii Bulbus. Chemical characterization analysis indicated that LBP-1 was only a glucan, whose average molecular weight was 30.5 kDa. Intraperitoneal administration of LBP-1 at the doses of 50-200mg/kg significantly inhibited the growth of Lewis lung carcinoma. Moreover, it could also obviously increase macrophage phagocytosis, splenocytes proliferation and cytokine (TNF-α, IL-2, IL-6 and IL-12) production to participate in the antitumor effects. LBP-1 could act as antitumor agent with immunomodulatory activity.
authors: Oncology Department, Zhejiang Provincial People's Hospital, Hangzhou 310024, China.
authors: Xin
authors: X
authors: Sun
authors: Institute of Hematology, Zhejiang Provincial Hospital of TCM, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China.
authors: Rui-Lan
authors: RL
authors: Gao
authors: Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors: Yao-Kang
authors: YK
authors: Xiong
authors: Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors: Qing-Cheng
authors: QC
authors: Huang
authors: Pharmacy Department, Zhejiang Provincial Hospital of TCM, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China. Electronic address: zjszyyxumin@163.com.
authors: Min
authors: M
authors: Xu
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D014867:Water / Q000737:chemistry
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D011134:Polysaccharides; D014867:Water
keywords: Antitumor; Characterization; Immunomodulatory; Lung carcinoma