title: [Association of 15 short tandem repeats loci with aggressive behavior].
abstract: OBJECTIVE
  To assess the association between aggressive behaviors and 15 short tandem repeats (STRs) loci.
  
  
  METHODS
  Peripheral blood samples from 541 army men with aggressive behaviors and 459 healthy individuals were collected. All sample were amplified with a AmpFlSTR Identifiler(TM) system and separated by electrophoresis to compare the genotypic and allelic frequencies of 15 STRs (CSF1PO, D2S1338, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D19S433, D21S11, FGA, THO1, TPOX and vWA) in the two groups.
  
  
  RESULTS
  A significant difference was found in allelic and genotypic frequencies at loci D2S1338 and D19S433 (P< 0.01) between the two groups, but not for the remaining 13 STR loci (P> 0.05). Univarite analysis also showed a significant difference for allele 16, genotypes 19-22, 22-24 on D2S1338 and genotypes 13-14.2 on D19S433 between the two groups (P= 0.0018, P= 0.0001, P= 0.0003, P= 0.0000), with the OR values being 7.380 (95%CI: 1.701-32.028), 0.051(95%CI: 0.007-0.388), 13.933(95%CI: 1.845-105.717), 0.349 (95%CI: 0.216-0.564), respectively.
  
  
  CONCLUSIONS
  D2S1338 and D19S433 may be associated with aggressive behavior. Allele 16 and genotype 22-24 on D2S1338 may be susceptible factors for the disease, whilst genotypes 19-22 on D2S1338 and 13-14.2 on D19S433 may confer a protective effect on it.
authors: Psychiatry Department, People Liberation Army 102nd Hospital, Changzhou, Jiangsu 213003, P.R.China. bahuajie@163.com.
authors: Chun
authors: C
authors: Yang
authors: Huajie
authors: H
authors: Ba
authors: Haiying
authors: H
authors: Yu
authors: Zhiqin
authors: Z
authors: Gao
authors: Hanqing
authors: H
authors: Zhao
authors: Jian
authors: J
authors: Sun
mesh_terms: D000328:Adult; D000374:Aggression; D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000235:genetics*; D018895:Microsatellite Repeats