title: Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor.
abstract: The RNA motifs that bind guanidinylated kanamycin A (G Kan A) and guanidinylated neomycin B (G Neo B) were identified via two-dimensional combinatorial screening (2DCS). The results of these studies enabled the "bottom-up" design of a small molecule inhibitor of oncogenic microRNA-10b.
authors: Department of Chemistry, The Scripps Research Institute, Scripps Florida, 130 Scripps Way #3A1, Jupiter, Florida 33458, USA. Disney@scripps.edu.
authors: Sai Pradeep
authors: SP
authors: Velagapudi
authors: Matthew D
authors: MD
authors: Disney
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001483:Base Sequence; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D005601:Framycetin / Q000378:metabolism*; D006801:Humans; D007612:Kanamycin / Q000378:metabolism*; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; C547183:MIRN10 microRNA, human; D035683:MicroRNAs; D054852:Small Molecule Libraries; D005601:Framycetin; D007612:Kanamycin