title: TDP-43 in ALS: stay on target…almost there.
abstract: ALS is associated with RNA processing impairments involving the RNA-binding protein TDP-43. Pioneering a novel RNA beacon to illuminate RNA trafficking in neurons, Alami et al. (2014) discover a cytoplasmic function for TDP-43, suggesting a new disease mechanism.
authors: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors: Ana
authors: A
authors: Jovičić
authors: Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.
authors: Aaron D
authors: AD
authors: Gitler
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000473:pathology; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D012313:RNA / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D012313:RNA