title: Neonatal seizures: advances in mechanisms and management.
abstract: Seizures occur in approximately 1 to 5 per 1000 live births and are among the most common neurologic conditions managed by a neonatal neurocritical care service. There are several, age-specific factors that are particular to the developing brain, which influence excitability and seizure generation, response to medications, and impact of seizures on brain structure and function. Neonatal seizures are often associated with serious underlying brain injury such as hypoxia-ischemia, stroke, or hemorrhage. Conventional, prolonged, continuous video electroencephalogram is the gold standard for detecting seizures, whereas amplitude-integrated EEG is a convenient and useful bedside tool.
authors: Departments of Neurology and Pediatrics, University of California, 505 Parnassus Avenue, M793, Box 0114, San Francisco, CA 94143-0114, USA. Electronic address: Hannah.Glass@ucsf.edu.
authors: Hannah C
authors: HC
authors: Glass
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000150:complications / Q000175:diagnosis; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D012640:Seizures / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D020521:Stroke / Q000150:complications / Q000175:diagnosis
chemical_list: D000927:Anticonvulsants
keywords: Brain injury; Developmental disability; Electroencephalography; Epilepsy; Infant, newborn; Magnetic resonance imaging; Neurocritical care; Seizures