title: [Application of quantitative evaluation on multicomponent drug interaction in anti-HIV research].
abstract: OBJECTIVE
  To quantitatively evaluate mutual relations of 4 component drugs in anti-HIV action.
  
  
  METHODS
  The effect of TCM four components on cell growth was detected using MTT assay. The antiviral effects of 4 components were observed at the maximal nonvenomous dose. The combination index (CI) value of combined two or four components were calculated using median-effect principle. The mutual relations of two or four components for antiviral actions were assessed using CI.
  
  
  RESULTS
  Synergism was dominant in combination of A and B, and the effect was dose-dependent. Antagonism was dominant in combination of C and D, and the effect was dose-dependent. But the combination of A, B, C, and D was synergistic when the inhibition rate was over 10%.
  
  
  CONCLUSIONS
  Median-effect principle can be used to quantitatively assess the anti-HIV effect of four components.
authors: College of Basic Medicine, Chengdu University of TCM, Chengdu 610075, China.
authors: Pei-Zhi
authors: PZ
authors: Dong
authors: College of Basic Medicine, Chengdu University of TCM, Chengdu 610075, China.
authors: Yong-Xiang
authors: YX
authors: Gao
authors: College of Basic Medicine, Chengdu University of TCM, Chengdu 610075, China.
authors: Xian-Bo
authors: XB
authors: Wu
authors: College of Basic Medicine, Chengdu University of TCM, Chengdu 610075, China.
authors: Guo-Dong
authors: GD
authors: Cen
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004357:Drug Synergism; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans
chemical_list: D000998:Antiviral Agents