title: Electrostatic correlations on the ionic selectivity of cylindrical membrane nanopores.
abstract: We characterize the role of electrostatic fluctuations on the charge selectivity of cylindrical nanopores confining electrolyte mixtures. To this end, we develop an extended one-loop theory that can account for correlation effects induced by the surface charge, nanoconfinement of the electrolyte, and interfacial polarization charges associated with the low permittivity membrane. We validate the quantitative accuracy of the theory by comparisons with previously obtained Monte-Carlo simulation data from the literature, and scrutinize in detail the underlying forces driving the ionic selectivity of the nanopore. In the biologically relevant case of electrolytes with divalent cations such as CaCl2 in negatively charged nanopores, electrostatic correlations associated with the dense counterion layer in the channel result in an increase of the pore coion density with the surface charge. This peculiarity analogous to the charge inversion phenomenon remains intact for dielectrically inhomogeneous pores, which indicates that the effect should be observable in nanofiltration membranes or DNA-blocked nanopores characterized by a low membrane permittivity. Our results show that a quantitatively accurate consideration of correlation effects is necessary to determine the ionic selectivity of nanopores in the presence of electrolytes with multivalent counterions.
authors: Institut de Recherche Interdisciplinaire USR3078 CNRS and Université Lille I, Parc de la Haute Borne, 52 Avenue de Halley, 59658 Villeneuve d'Ascq, France.
authors: Sahin
authors: S
authors: Buyukdagli
authors: Department of Applied Physics and COMP Center of Excellence, Aalto University School of Science, P.O. Box 11000, FI-00076 Aalto, Espoo, Finland.
authors: T
authors: T
authors: Ala-Nissila
mesh_terms: D004573:Electrolytes / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D008567:Membranes, Artificial; D009010:Monte Carlo Method; D058608:Nanopores / Q000648:ultrastructure*; D055672:Static Electricity
chemical_list: D004573:Electrolytes; D007477:Ions; D008567:Membranes, Artificial