title: Controlled release of an anti-cancer drug from DNA structured nano-films.
abstract: We demonstrate the generation of systemically releasable anti-cancer drugs from multilayer nanofilms. Nanofilms designed to drug release profiles in programmable fashion are promising new and alternative way for drug delivery. For the nanofilm structure, we synthesized various unique 3-dimensional anti cancer drug incorporated DNA origami structures (hairpin, Y, and X shaped) and assembled with peptide via layer-by-layer (LbL) deposition method. The key to the successful application of these nanofilms requires a novel approach of the influence of DNA architecture for the drug release from functional nano-sized surface. Herein, we have taken first steps in building and controlling the drug incorporated DNA origami based multilayered nanostructure. Our finding highlights the novel and unique drug release character of LbL systems in serum condition taken full advantages of DNA origami structure. This multilayer thin film dramatically affects not only the release profiles but also the structure stability in protein rich serum condition.
authors: 1] School of Materials Science and Engineering, Georgia Institute of Technology, 771 Ferst Drive, Atlanta, GA 30332, USA [2].
authors: Younghyun
authors: Y
authors: Cho
authors: 1] Department of Chemical Engineering, University of Seoul, Seoul 130-743, Republic of Korea [2].
authors: Jong Bum
authors: JB
authors: Lee
authors: School of Chemical Engineering and Materials Science, Chung-Ang University, Seoul 156-756, Republic of Korea.
authors: Jinkee
authors: J
authors: Hong
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis / Q000737:chemistry* / Q000378:metabolism; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D004317:Doxorubicin / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D011107:Polylysine / Q000737:chemistry; D013050:Spectrometry, Fluorescence
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011107:Polylysine; D004317:Doxorubicin; D004247:DNA