title: Fiber typing in aging muscle.
abstract: It is accepted widely that fast-twitch muscle fibers are preferentially impacted in aging muscle, yet we hypothesize that this is not valid when aging muscle atrophy becomes severe. In this review, we summarize the evidence of fiber type-specific effect in aging muscle and the potential confounding roles of fibers coexpressing multiple myosin heavy-chain isoforms and their histochemical identification.
authors: 1Department of Kinesiology, 2McGill University Health Centre, and 3Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada.
authors: Fennigje M
authors: FM
authors: Purves-Smith
authors: Nicolas
authors: N
authors: Sgarioto
authors: Russell T
authors: RT
authors: Hepple
mesh_terms: D000251:Adenosine Triphosphatases; D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D006651:Histocytochemistry; D006801:Humans; D018656:Muscle Fibers, Fast-Twitch / Q000737:chemistry / Q000145:classification* / Q000502:physiology*; D018657:Muscle Fibers, Slow-Twitch / Q000737:chemistry / Q000145:classification* / Q000502:physiology*; D009133:Muscular Atrophy / Q000503:physiopathology*; D018995:Myosin Heavy Chains / Q000032:analysis; D020033:Protein Isoforms / Q000032:analysis
chemical_list: D020033:Protein Isoforms; D000251:Adenosine Triphosphatases; D018995:Myosin Heavy Chains