title: Toxicity reference values for polybrominated diphenyl ethers: risk assessment for predatory birds and mammals from two Chinese lakes.
abstract: PBDEs are persistent organic pollutants, and have the capability to produce adverse effects on organisms. Aquatic piscivorous species at higher trophic levels have the greatest exposure risk. Information on the toxic potency of a commercial PBDE mixture, DE-71, to mink and American kestrel was reviewed, and dietary- and tissue-based TRVs were derived and evaluated for ecological risk assessment of aquatic piscivorous species inhabiting wetland areas in China. The effect on mink thyroid function was identified as the most appropriate and protective endpoint for deriving the TRV s for mammals. The TRV was based on dietary exposure, and wa s0.1 mg DE-71/kg (wm) or 0.01 mg DE-71/kg (bm)/day (ADI); for liver of mammals,the TRV was 1.2 mg LPBDEslkg (lm). For birds, reproductive effects on American kestrels were used to derive the TRVs, in which an overall UF of 3.0 was used. The TRV was based on dietary exposure, and was 0.1 mg DE-71/kg (wm) or 0.018 mg DE-71/kg (bm)/day (ADI); for eggs of birds, the TRV was 2.35 jlgLPBDEs/g (lm). Reported concentrations of PBDEs in livers of aquatic mammals found dead, and in fish and bird eggs from Chinese wetland areas were compiled and compared to the corresponding criteria values. Results indicated that TRV values reported in this study can be used as indicators for screening-level risk assessment of piscivorous species in Chinese aquatic systems. Furthermore, based on monitoring concentrations of PBDEs in fishes from two lakes (DCL and TL) in China and the dietary-based TRV of 0.1 mg DE-71/kg (wm), a screening-level risk assessment of PBDEs was performed for predatory birds and mammals. The results suggest that concentrations of PBDEs in these two areas would not be expected to cause any adverse effects on the local fish-eating wild birds and mammals.
authors: College of Environment and Resources, Inner Mongolia University, Huhhot, 010021, Inner Mongolia, China.
authors: Ruiqing
authors: R
authors: Zhang
authors: Jianyang
authors: J
authors: Guo
authors: Fengchang
authors: F
authors: Wu
authors: Yunsong
authors: Y
authors: Mu
authors: John P
authors: JP
authors: Giesy
authors: Hong
authors: H
authors: Chang
authors: Xiaoli
authors: X
authors: Zhao
authors: Chenglian
authors: C
authors: Feng
mesh_terms: D000818:Animals; D001717:Birds; D002681:China; D055768:Halogenated Diphenyl Ethers / Q000493:pharmacokinetics / Q000633:toxicity*; D060106:Lakes / Q000032:analysis*; D008907:Mink; D019055:No-Observed-Adverse-Effect Level; D012016:Reference Values; D018570:Risk Assessment; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D055768:Halogenated Diphenyl Ethers; D014874:Water Pollutants, Chemical; C086401:pentabromodiphenyl ether