title: [Pulmonary malt lymphoma].
abstract: This review will describe the current knowledge in the pathophysiology, diagnosis, prognosis and treatment of pulmonary MALT (Mucosa Associated Lymphoid Tissue) lymphoma. Pulmonary MALT lymphomas are low-grade B cell lymphoma and are the most frequent lymphomas arising from the lung. Tumour cells arise from mucosa associated lymphoid tissue. Unlike other sites, no pathogen has been associated with pulmonary location of MALT lymphoma. However addictive translocations involving the MALT1 gene are frequently evidenced Patients are frequently asymptomatic and present with a chronic alveolar opacity. Diagnosis requires histology that may be retrieved by minimally invasive procedures during bronchial endoscopy or by CT scan guided percutaneous biopsies. Prognosis is good and treatment may vary with abstention, surgery, radiotherapy, immunotherapy or chemotherapy.
authors: Service de pneumologie A, centre de compétences maladies rares pulmonaires, AP-HP hôpital Bichat-Claude Bernard, 46, rue Henri Huchard, 75877 Paris cedex 18, France.
authors: Raphaël
authors: R
authors: Borie
authors: Service d'anatomie pathologique, AP-HP hôpital Tenon, 4, rue de la Chine, 75970 Paris, France, Laboratoire de biologie cellulaire et d'immunopathologie pulmonaire, ER2, GRC-04, université Pierre-et Marie-Curie Paris 6, Paris, France.
authors: Martine
authors: M
authors: Antoine
authors: Laboratoire de biologie cellulaire et d'immunopathologie pulmonaire, ER2, GRC-04, université Pierre-et Marie-Curie Paris 6, Paris, France, Service de pneumologie et de réanimation, Centre de compétences maladies rares pulmonaires, AP-HP-Hôpital Tenon, 4, rue de la Chine, 75970 Paris, France.
authors: Jacques
authors: J
authors: Cadranel
authors: Laboratoire de biologie cellulaire et d'immunopathologie pulmonaire, ER2, GRC-04, université Pierre-et Marie-Curie Paris 6, Paris, France, Service de pneumologie et de réanimation, Centre de compétences maladies rares pulmonaires, AP-HP-Hôpital Tenon, 4, rue de la Chine, 75970 Paris, France.
authors: Marie
authors: M
authors: Wislez
mesh_terms: D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D011379:Prognosis; D035583:Rare Diseases / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy
keywords: chronic alveolar opacity; clonality; oncogene; translocation