title: Ribosomal alteration-derived signals for cytokine induction in mucosal and systemic inflammation: noncanonical pathways by ribosomal inactivation.
abstract: Ribosomal inactivation damages 28S ribosomal RNA by interfering with its functioning during gene translation, leading to stress responses linked to a variety of inflammatory disease processes. Although the primary effect of ribosomal inactivation in cells is the functional inhibition of global protein synthesis, early responsive gene products including proinflammatory cytokines are exclusively induced by toxic stress in highly dividing tissues such as lymphoid tissue and epithelia. In the present study, ribosomal inactivation-related modulation of cytokine production was reviewed in leukocyte and epithelial pathogenesis models to characterize mechanistic evidence of ribosome-derived cytokine induction and its implications for potent therapeutic targets of mucosal and systemic inflammatory illness, particularly those triggered by organellar dysfunctions.
authors: Laboratory of Mucosal Exposome and Biomodulation, Department of Microbiology and Immunology, Pusan National University School of Medicine, Yangsan 626-870, Republic of Korea ; Immunoregulatory Therapeutics Group in Brain Busan 21 Project, Busan 609-735, Republic of Korea ; Medical Research Institute, Pusan National University, Busan 609-735, Republic of Korea.
authors: Yuseok
authors: Y
authors: Moon
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress; D004847:Epithelial Cells / Q000166:cytology; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D007962:Leukocytes / Q000166:cytology; D009092:Mucous Membrane / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012335:RNA, Ribosomal / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D016328:NF-kappa B; D012335:RNA, Ribosomal