title: Surface smoothing: a way back in early brain morphogenesis.
abstract: In this article we propose to investigate the analogy between early cortical folding process and cortical smoothing by mean curvature flow. First, we introduce a one-parameter model that is able to fit a developmental trajectory as represented in a Volume-Area plot and we propose an efficient optimization strategy for parameter estimation. Second, we validate the model on forty cortical surfaces of preterm newborns by comparing global geometrical indices and trajectories of central sulcus along developmental and simulation time.
authors: Aix-Marseille Univ, Departement d'Informatique et Interractions, Marseille, France. julien.lefevre@univ-amu.fr
authors: Julien
authors: J
authors: Lefèvre
authors: Ecole Centrale Marseille, France.
authors: Victor
authors: V
authors: Intwali
authors: UMR 663, INSERM, Universite Paris Descartes, Paris, France.
authors: Lucie
authors: L
authors: Hertz-Pannier
authors: Geneva University Hospitals, Department of Pediatrics, Switzerland.
authors: Petra S
authors: PS
authors: Hüppi
authors: CEA, I2BM, DSV, NeuroSpin, Gif/Yvette, France.
authors: Jean-Francois
authors: JF
authors: Mangin
authors: U992, INSERM, NeuroSpin, Gif/Yvette, France.
authors: Jessica
authors: J
authors: Dubois
authors: UMR 663, INSERM, Universite Paris Descartes, Paris, France.
authors: David
authors: D
authors: Germanaud
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology* / Q000254:growth & development*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007231:Infant, Newborn; D007234:Infant, Premature; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009024:Morphogenesis / Q000502:physiology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity