title: Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis.
abstract: Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.
authors: Laboratory of Genetics of Neurological Complex Disorders & Department of Neurology, Division of Neuroscience, Institute of Experimental Neurology (INSPE), San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy.
authors: Clara
authors: C
authors: Guaschino
authors: Federica
authors: F
authors: Esposito
authors: Giuseppe
authors: G
authors: Liberatore
authors: Bruno
authors: B
authors: Colombo
authors: Pietro
authors: P
authors: Annovazzi
authors: Emanuele
authors: E
authors: D'Amico
authors: Paola
authors: P
authors: Cavalla
authors: Elisabetta
authors: E
authors: Capello
authors: Ruggero
authors: R
authors: Capra
authors: Daniela
authors: D
authors: Galimberti
authors: Gioacchino
authors: G
authors: Tedeschi
authors: Luigi
authors: L
authors: Grimaldi
authors: Maurizio
authors: M
authors: Leone
authors: Sandra
authors: S
authors: D'Alfonso
authors: Vittorio
authors: V
authors: Martinelli
authors: Giancarlo
authors: G
authors: Comi
authors: Filippo
authors: F
authors: Martinelli-Boneschi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016000:Cluster Analysis; D018450:Disease Progression; D005190:Family; D020022:Genetic Predisposition to Disease; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology* / Q000503:physiopathology*; D010641:Phenotype; D015995:Prevalence; D055815:Young Adult