title: Structure and function of toll-like receptor 8.
abstract: Toll-like receptors (TLRs) sense pathogen-associated molecular patterns originating from invading microorganisms and initiate innate immune responses. Recent structural studies of TLR-ligand complexes have revealed the detailed molecular mechanisms by which each TLR specifically recognizes its own ligands. This review focuses on the structure of TLR8 and discusses the similarities and diversities of TLR-ligand interactions and signaling mechanisms.
authors: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors: Umeharu
authors: U
authors: Ohto
authors: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors: Hiromi
authors: H
authors: Tanji
authors: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; CREST, JST, Japan. Electronic address: shimizu@mol.f.u-tokyo.ac.jp.
authors: Toshiyuki
authors: T
authors: Shimizu
mesh_terms: D006801:Humans; D008958:Models, Molecular; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction; D051200:Toll-Like Receptor 8 / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D011971:Receptors, Immunologic; D051200:Toll-Like Receptor 8
keywords: Innate immunity; Structural biology; Toll-like receptor