title: Cross-linked carboxybetaine SAMs enable nanoparticles with remarkable stability in complex media.
abstract: A photo-cross-linkable carboxybetaine (CB)-terminated thiol with only one CB headgroup was introduced to modify gold nanoparticles (GNPs) via self-assembled monolayers (SAMs). This CB-terminated thiol consists of three moieties: (a) an anchoring thiol group, which binds directly to the GNP surface, (b) a CB terminal group, which is highly resistant to protein adsorption, and (c) a diacetylene group in the middle, which is converted to a poly(enyne) structure during UV irradiation via 1,4-topochemical polymerization. Results show that, after cross-linking, CB-modified GNPs are highly resistant to protein adsorption from undiluted human blood serum and cell uptake, and are stable at low pH and high temperature. This cross-linkable CB thiol holds tremendous potentials for biomedical applications where stable and thin coatings are needed.
authors: Department of Chemical Engineering, University of Washington , Seattle, Washington 98195, United States.
authors: Wei
authors: W
authors: Yang
authors: Jean-Rene
authors: JR
authors: Ella-Menye
authors: Sijun
authors: S
authors: Liu
authors: Tao
authors: T
authors: Bai
authors: Daqian
authors: D
authors: Wang
authors: Qiuming
authors: Q
authors: Yu
authors: Yuting
authors: Y
authors: Li
authors: Shaoyi
authors: S
authors: Jiang
mesh_terms: D001622:Betaine / Q000031:analogs & derivatives / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D015394:Molecular Structure; D010316:Particle Size; D055668:Photochemical Processes; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties; D014466:Ultraviolet Rays
chemical_list: D003432:Cross-Linking Reagents; D013438:Sulfhydryl Compounds; D001622:Betaine; D006046:Gold