title: [Changes of bone mineral density and bone metabolic marker in patients with subclinical hypothyroidism].
abstract: OBJECTIVE
  To investigate the change of bone mineral density and bone metabolism biochemical markers in subclinical hypothyroidism.
  
  
  METHODS
  This study included total 122 patients with subclinical hypothyroidism and 153 healthy age and gender matched people as control. All the patients and controls were subjected to the measurements of bone density by dual energy X-ray absorptiometry (DEXA), and serum free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), Ca2+, PO4(3+), alkaline phosphatase (ALP) levels. All the data was analyzed statistically with the stratification of gender and menopause status.
  
  
  RESULTS
  Compared to the control, the patients with subclinical hypothyroidism had significantly higher incidence of bone mass loss (P < 0.005) and lower level of Serum Ca2+ (P < 0.05) and higher levels of serum PO4(3+), T-value and Z-value (P < 0.05). Furthermore, premenopausal women had higher Z-value (P < 0.01) , but no significantly differences of T-value, serum PO4(3+) was found either in pre-menopause or post-menopause women when compared to the control. Multiple linear regression analysis showed gender (B = 0.543, P < 0.0001) was positive correlation with T value, female had lower T values. Moreover, T value was negative correlated to menopausal status (B = -0.274, P = 0.001), age (B = -0.161, P < 0.0001) and TSH (B = -0.108, P < 0.0001).
  
  
  CONCLUSIONS
  Subclinical hypothyroism appears decreased serum calcium and low bone density.
authors: Department of General Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Li-Bo
authors: LB
authors: Liang
authors: Department of Physical Examination Center, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: You-Juan
authors: YJ
authors: Wang
authors: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Mei
authors: M
authors: Zhang
authors: Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Heng-Jian
authors: HJ
authors: Huang
authors: Department of General Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Shuang-Qing
authors: SQ
authors: Li
mesh_terms: D015502:Absorptiometry, Photon; D015415:Biomarkers; D015519:Bone Density; D001842:Bone and Bones / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis / Q000473:pathology*; D017698:Postmenopause; D017697:Premenopause; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D015415:Biomarkers; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine