title: Targeted in vivo imaging of microscopic tumors with ferritin-based nanoprobes across biological barriers.
abstract: The avascular microscopic breast and brain tumors (<1-2 mm diameter) can be noninvasively detected by designing human heavy-chain ferritin (HFn)-based nanoparticles as molecular probes for near-infrared fluorescence and magnetic resonance imaging. The intravenously injected HFn-based nano-particles (Cy5.5-HFn and M-HFn) can cross the endothelium, epithelium, and blood-brain barriers and be internalized into tumor cells.
authors: Franco-Chinese Bio-Mineralization and Nano-Structures Laboratory, Key Laboratory of the Earth's Deep Interior, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing, 100029, China.
authors: Changqian
authors: C
authors: Cao
authors: Xuxia
authors: X
authors: Wang
authors: Yao
authors: Y
authors: Cai
authors: Lei
authors: L
authors: Sun
authors: Lanxiang
authors: L
authors: Tian
authors: Hao
authors: H
authors: Wu
authors: Xiaoqing
authors: X
authors: He
authors: Hao
authors: H
authors: Lei
authors: Weifeng
authors: W
authors: Liu
authors: Guanjun
authors: G
authors: Chen
authors: Rixiang
authors: R
authors: Zhu
authors: Yongxin
authors: Y
authors: Pan
mesh_terms: D000818:Animals; D001692:Biological Transport; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism; D002232:Carbocyanines / Q000737:chemistry; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry / Q000378:metabolism*; D005293:Ferritins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: C098793:CY5.5 cyanine dye; D002232:Carbocyanines; D003287:Contrast Media; D005293:Ferritins
keywords: biological barrier; ferritin; iron oxide nanoparticles; molecular imaging; tumor