title: Rapid generation of privileged substructure-based compound libraries with structural diversity and drug-likeness.
abstract: A library of privileged-substructure-based, heterocyclic compounds was constructed by a sequence of Ugi four-component reactions incorporating the indole motif and microwave-assisted cyclizations in branched pathways. Cheminformatic analysis confirmed that the library exhibited a high degree of structural diversity and good drug-likeness.
authors: CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , 555 Zuchongzhi Road, Shanghai 201203, China.
authors: Lei
authors: L
authors: Zhang
authors: Mingyue
authors: M
authors: Zheng
authors: Fei
authors: F
authors: Zhao
authors: Yun
authors: Y
authors: Zhai
authors: Hong
authors: H
authors: Liu
mesh_terms: D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D054852:Small Molecule Libraries