title: Effect of the ethanol extract of Pleurotus eryngii on bone metabolism in ovariectomized rats.
abstract: OBJECTIVE
  Postmenopausal bone loss and the possible progression to osteoporosis are a major health concern. Mushrooms have been recognized as functional foods. Pleurotus eryngii extract has been reported to have estrogenic activity, suggesting that its consumption may mitigate postmenopausal bone loss. The aim of the present study was to determine the effect of supplementation with an ethanol extract of P. eryngii on bone metabolism in a postmenopausal osteoporosis rat model.
  
  
  METHODS
  Female 12-week-old Wistar rats were subjected to either sham operation or bilateral ovariectomy. The ovariectomized rats were then subdivided into two groups: one fed the extract and the other not. Twelve weeks after surgery, indices of bone mass, bone histomorphometry, and bone mechanics were measured.
  
  
  RESULTS
  The right femur bone mineral content and density of the ovariectomized group were significantly lower than in the Sham group, and extract supplementation did not have any significant effect on these differences. Furthermore, ovariectomy significantly increased measures of mineralizing surface and bone formation rates; again, extract supplementation again had no significant effect.
  
  
  CONCLUSIONS
  Our findings suggest that the ethanol extract of P. eryngii does not alter bone metabolism in ovariectomized rats, suggesting that consumption of P. eryngii may not be beneficial in slowing bone loss after menopause.
authors: Department of Obstetrics and Gynecology, School of Medicine, Aichi Medical University , Nagakute.
authors: Y
authors: Y
authors: Ohyama
authors: H
authors: H
authors: Matsushita
authors: A
authors: A
authors: Minami
authors: H
authors: H
authors: Kanazawa
authors: T
authors: T
authors: Suzuki
authors: K
authors: K
authors: Watanabe
authors: A
authors: A
authors: Wakatsuki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects*; D045424:Complex Mixtures / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D010052:Ovariectomy / Q000009:adverse effects*; D020076:Pleurotus; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D045424:Complex Mixtures
keywords: BONE HISTOMORPHOMETRY; BONE MINERAL DENSITY; MENOPAUSE; MUSHROOM; RAT