title: Lack of association between vitamin D receptor gene ApaI, BsmI, and TaqI polymorphisms and primary biliary cirrhosis risk: a meta-analysis.
abstract: Previous studies have reported the association between vitamin D receptor (VDR) polymorphisms and the risk of primary biliary cirrhosis (PBC), although these results remain controversial. The aim of this meta-analysis was to evaluate the association of three polymorphisms in VDR with PBC risk. The relevant studies were identified through an electronic database search carried out in September 2013. The crude odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the association between VDR polymorphisms and PBC risk. Six eligible studies which met our selection criteria were included. Overall, the ApaI, BsmI, and TaqI polymorphisms in the VDR gene were not associated with PBC risk (ApaI A vs a OR = 1.132, 95% CI = 0.870-1.472, p = 0.355; BsmI B vs b OR = 1.148, 95% CI = 0.697-1.891, p = 0.589; TaqI t vs T OR = 1.1432, 95% CI = 0.709-1.841, p = 0.584). Furthermore, in subgroup analysis by ethnicity for the ApaI, BsmI, and TaqI polymorphisms, there were no significant results in either Caucasians or Asians under the allele contrast and recessive and dominant models. This meta-analysis indicated that VDR polymorphisms were not a risk factor for PBC. Larger and more carefully designed studies are needed to verify our results.
authors: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
authors: Cuiju
authors: C
authors: Mo
authors: Yu
authors: Y
authors: Lu
authors: Yan
authors: Y
authors: Deng
authors: Jian
authors: J
authors: Wang
authors: Li
authors: L
authors: Xie
authors: Taijie
authors: T
authors: Li
authors: Yu
authors: Y
authors: He
authors: Xue
authors: X
authors: Qin
authors: Shan
authors: S
authors: Li
mesh_terms: D015252:Deoxyribonucleases, Type II Site-Specific; D020022:Genetic Predisposition to Disease; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000209:etiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D018167:Receptors, Calcitriol / Q000235:genetics*; D012306:Risk
chemical_list: D018167:Receptors, Calcitriol; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific; C038485:GGGCCC-specific type II deoxyribonucleases; C027046:TCGA-specific type II deoxyribonucleases