title: Induction of phosphorylated c-Jun in neonatal spinal motoneurons after axonal injury is coincident with both motoneuron death and regeneration.
abstract: c-Jun activation has been implicated not only in neuronal degeneration, but also in survival and regeneration. Here, we investigated c-Jun activation in injured motoneurons by using a nerve crush model in neonatal rats. We identified two distinct subpopulations of motoneurons: about 60% underwent degeneration following injury whereas the remaining 40% survived and induced a regeneration response at 3 weeks post injury. However, all motoneurons examined expressed phosphorylated-c-Jun-immunoreactivity (p-c-Jun-IR) at the early stage of 3 days following injury. These results suggest that active c-Jun was induced in all neonatal motoneurons following nerve crush injury, regardless of whether they were destined to degenerate or undergo successful regeneration at a later stage. Our findings therefore support the hypothesis that active c-Jun is involved in both neuronal degeneration and regeneration.
authors: Faculty of Medicine, School of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China; Department of Anatomy, University of Hong Kong, Hong Kong, China.
authors: Qiuju
authors: Q
authors: Yuan
authors: Huanxing
authors: H
authors: Su
authors: Jiasong
authors: J
authors: Guo
authors: Wutian
authors: W
authors: Wu
authors: Zhi-Xiu
authors: ZX
authors: Lin
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D001917:Brachial Plexus / Q000166:cytology / Q000293:injuries* / Q000502:physiology*; D016923:Cell Death / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D007150:Immunohistochemistry; D009046:Motor Neurons / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D010766:Phosphorylation; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D016755:Proto-Oncogene Proteins c-jun
keywords: Phosphorylated c-Jun; axonal injury; motoneuron; regeneration; spinal cord