title: Neural and genetic correlates of binge drinking among college women.
abstract: Ninety-seven female students were assigned to groups consisting of 55 infrequent and 42 frequent binge drinkers. The groups were compared on self-report measures of impulsivity, sensation seeking, and alexithymia, as well as several measures relevant to neural and genetic mechanisms, such as brain activation during a time estimation task and selected genotypes. Analyses of stimulus-locked brain activity revealed a slow cortical potential over the right parietal cortex during time estimation that was more negative among frequent binge drinkers. This group also showed a greater prevalence of a CHRM2 genotype previously associated with substance dependence and Major Depressive Disorder as well as a modest elevation on a non-planning impulsiveness scale. We conclude that the enhanced brain activation shown by binge drinkers compensates for an underlying deficit. That deficit may be reflected in poor planning skills and a genetic difference indicating increased risk for problems in later life.
authors: Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA. Electronic address: lbauer@uchc.edu.
authors: Lance O
authors: LO
authors: Bauer
authors: Department of Psychology, Texas State University, San Marcos, TX, USA.
authors: Natalie A
authors: NA
authors: Ceballos
mesh_terms: D000293:Adolescent; D000342:Affective Symptoms / Q000523:psychology; D000428:Alcohol Drinking / Q000523:psychology; D000704:Analysis of Variance; D063425:Binge Drinking / Q000235:genetics* / Q000523:psychology*; D004247:DNA / Q000235:genetics; D003627:Data Interpretation, Statistical; D004569:Electroencephalography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007175:Impulsive Behavior / Q000523:psychology; D008564:Membrane Potentials / Q000502:physiology; D010551:Personality; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011597:Psychomotor Performance / Q000502:physiology; D043585:Receptor, Muscarinic M2 / Q000235:genetics; D011963:Receptors, GABA-A / Q000235:genetics; D013334:Students; D013998:Time Perception / Q000502:physiology; D014495:Universities; D055815:Young Adult
chemical_list: C487078:CHRM2 protein, human; C484841:GABRA2 protein, human; D043585:Receptor, Muscarinic M2; D011963:Receptors, GABA-A; D004247:DNA; C489948:ANKK1 protein, human; D017346:Protein Serine-Threonine Kinases
keywords: Alcohol; Binge drinking; CHRM2; College students; Contingent negative variation; Electroencephalography; Evoked potential; Gene; Time