title: Regioselective ruthenium-catalyzed carbonylative direct arylation of five-membered and condensed heterocycles.
abstract: A ruthenium-catalyzed carbonylative CH bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp(2))-C(sp(2)) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations.
authors: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, 18059 Rostock (Germany), Fax: (+49) 381-1281-51113.
authors: Jola
authors: J
authors: Pospech
authors: Anis
authors: A
authors: Tlili
authors: Anke
authors: A
authors: Spannenberg
authors: Helfried
authors: H
authors: Neumann
authors: Matthias
authors: M
authors: Beller
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006860:Hydrogen Bonding; D007659:Ketones / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D007659:Ketones; D012428:Ruthenium
keywords: CH bond functionalization; carbonylative coupling; heterocycles; multicomponent reactions; ruthenium