title: HiBrowse: multi-purpose statistical analysis of genome-wide chromatin 3D organization.
abstract: Recently developed methods that couple next-generation sequencing with chromosome conformation capture-based techniques, such as Hi-C and ChIA-PET, allow for characterization of genome-wide chromatin 3D structure. Understanding the organization of chromatin in three dimensions is a crucial next step in the unraveling of global gene regulation, and methods for analyzing such data are needed. We have developed HiBrowse, a user-friendly web-tool consisting of a range of hypothesis-based and descriptive statistics, using realistic assumptions in null-models.
  
  
  METHODS
  HiBrowse is supported by all major browsers, and is freely available at http://hyperbrowser.uio.no/3d. Software is implemented in Python, and source code is available for download by following instructions on the main site.
authors: Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Mathematics, University of Oslo, Problemveien 7, 0313 Oslo and ELIXIR project, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Norway.
authors: Jonas
authors: J
authors: Paulsen
authors: Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Mathematics, University of Oslo, Problemveien 7, 0313 Oslo and ELIXIR project, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Norway.
authors: Geir Kjetil
authors: GK
authors: Sandve
authors: Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Mathematics, University of Oslo, Problemveien 7, 0313 Oslo and ELIXIR project, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Norway.
authors: Sveinung
authors: S
authors: Gundersen
authors: Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Mathematics, University of Oslo, Problemveien 7, 0313 Oslo and ELIXIR project, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Norway.
authors: Tonje G
authors: TG
authors: Lien
authors: Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Mathematics, University of Oslo, Problemveien 7, 0313 Oslo and ELIXIR project, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Norway.
authors: Kai
authors: K
authors: Trengereid
authors: Institute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Mathematics, University of Oslo, Problemveien 7, 0313 Oslo and ELIXIR project, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, NorwayInstitute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Mathematics, University of Oslo, Problemveien 7, 0313 Oslo and ELIXIR project, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, NorwayInstitute for Cancer Genetics and Informatics, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, PO Box 4950, Nydalen, 0424 Oslo, Department of Mathematics, University of Oslo, Problemveien 7, 0313 Oslo and ELIXIR project, Department of Informatics, University of Oslo, Problemveien 7, 0313 Oslo, Norway.
authors: Eivind
authors: E
authors: Hovig
mesh_terms: D002843:Chromatin / Q000737:chemistry*; D003627:Data Interpretation, Statistical; D016678:Genome; D023281:Genomics / Q000379:methods; D059014:High-Throughput Nucleotide Sequencing; D012984:Software
chemical_list: D002843:Chromatin