title: Effect of oxcarbazepine on bone mineral density and biochemical markers of bone metabolism in patients with epilepsy.
abstract: OBJECTIVE
  Antiepileptic drugs (AEDs) may cause adverse effects on bone metabolism and bone mineral density (BMD). The aim of this study is to determine the effect of oxcarbazepine (OXC) monotherapy on biochemical markers of bone metabolism and BMD in epilepsy patients.
  
  
  METHODS
  Forty-one new onset drug naïve epilepsy patients were recruited (19 females, 22 males; mean age: 28.2±8.4 years). We measured biochemical markers of bone metabolism (serum calcium, phosphate, bone alkaline phosphatase, parathyroid hormone, osteocalcin, insulin-like growth factor (IGF)-1, C-telopeptide, Vitamin D3 levels) and BMD by DEXA (dual energy X-ray absorptiometry) method in all patients before and after a long-term OXC monotherapy.
  
  
  RESULTS
  Most of biochemical markers were not changed significantly, but serum calcium (p=0.0087) and bone specific ALP was reduced (p=0.0499) significantly after OXC monotherapy in epilepsy patients. BMD at the lumbar spine (L2 to L4) was significantly increased after OXC monotherapy (p=0.0001), revealed by repeated measures ANOVA with Bonferroni's correction of confounders including sex, age, average dose, and treatment duration. However, BMD at the lumbar spine (L2 to L4) was significantly increased (p=0.012) only in female patients in each gender analysis.
  
  
  CONCLUSIONS
  This study demonstrates that a long-term OXC monotherapy does not appear to have harmful effect on bone health in drug naïve epilepsy patients.
authors: Department of Neurology, Seoul National University Boramae Hospital, Seoul, Republic of Korea.
authors: Dae Lim
authors: DL
authors: Koo
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Republic of Korea.
authors: Kyoung Jin
authors: KJ
authors: Hwang
authors: Department of Neurology, East Suwon Hospital, Suwon, Republic of Korea.
authors: Suk Won
authors: SW
authors: Han
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Republic of Korea.
authors: Ji Young
authors: JY
authors: Kim
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Republic of Korea. Electronic address: eyunsjoo@hanmail.net.
authors: Eun Yeon
authors: EY
authors: Joo
authors: Department of Neurology, Kyung Hee University East-West Neo Medical Center, Seoul, Republic of Korea.
authors: Won-Chul
authors: WC
authors: Shin
authors: Department of Neurology, Ewha Womans University School of Medicine, Seoul, Republic of Korea.
authors: Hyang Woon
authors: HW
authors: Lee
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Republic of Korea.
authors: Dae-Won
authors: DW
authors: Seo
authors: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Seoul, Republic of Korea. Electronic address: sbhong@skku.edu.
authors: Seung Bong
authors: SB
authors: Hong
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D000927:Anticonvulsants / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects*; D001851:Bone Diseases, Metabolic / Q000139:chemically induced*; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives*; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; C476610:oxcarbamazepine; D002220:Carbamazepine
keywords: Bone metabolism; Bone mineral density; Epilepsy; Oxcarbazepine