title: Atypical antipsychotic use is an independent predictor for the increased mean platelet volume in patients with schizophrenia: A preliminary study.
abstract: BACKGROUND
  Cardiovascular diseases, cardiovascular risk factors, and mortality due to these situations are more frequently encountered in schizophrenic patients when compared with the general population. The mean platelet volume (MPV) is a surrogate biomarker of the platelet activity and an useful prognostic test in cardiometabolic diseases. The aim of this study was to investigate what influenced MPV levels in patients with schizophrenia.
  
  
  METHODS
  We evaluated hospital records of 60 hospitalized schizophrenia patients. Thirty age- and sex-matched healthy control subjects were also included as a control group.
  
  
  RESULTS
  MPV levels were significantly higher in patients who were on atypical antipsychotic drugs than in patients who were not using any drug (9.2 ± 0.8 vs. 8.6 ± 0.8 fL, P = 0.016) and also higher than control group (9.2 ± 0.8 vs. 8.1 ± 0.9 fL, P < 0.001). Furthermore, patients who were not using antipsychotics had higher MPV than control group (8.6 ± 0.8 vs. 8.1 ± 0.9 fL, P = 0.036). Atypical antipsychotic use [Odds ratio (OR) =6.152, 95% confidence interval (CI,) P = 0.003)] and platelet distribution width (OR = 0.989, 95% CI, P = 0.032) were associated with high MPV levels in univariate analysis. In multivariate logistic regression model, only atypical antipsychotics use (OR = 6.152, 95% CI, P = 0.003) was found to be independent predictor of high MPV levels after adjustment of other potential confounders (age, gender, presence of hypertension, diabetes mellitus, hyperlipidemia, and smoking).
  
  
  CONCLUSIONS
  MPV seems to be influenced not only by schizophrenia itself but also by atypical antipsychotic drugs. It might be concluded that schizophrenic patients are under increased risk for cardiometabolic diseases and risk factors and this risk is higher in patients on atypical antipsychotic treatment.
authors: Psychiatry Clinic, Sivas Numune Hospital, Sivas, Turkey.
authors: Murat
authors: M
authors: Semiz
authors: Department of Cardiology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Hasan
authors: H
authors: Yücel
authors: Department of Psychiatry, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Onder
authors: O
authors: Kavakçı
authors: Department of Psychiatry, Abant Izzet Baysal University School of Medicine, Bolu, Turkey.
authors: Osman
authors: O
authors: Yıldırım
authors: Department of Cardiology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Ali
authors: A
authors: Zorlu
authors: Department of Cardiology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Mehmet Birhan
authors: MB
authors: Yılmaz
authors: Department of Cardiology, Cumhuriyet University School of Medicine, Sivas, Turkey.
authors: Zekeriya
authors: Z
authors: Küçükdurmaz
authors: Psychiatry Clinic, Bolu Izzet Baysal Mental Health Hospital, Bolu, Turkey.
authors: Fatih
authors: F
authors: Canan
keywords: Atypical antipsychotics; cardiovascular disease; mean platelet volume; schizophrenia