title: The Janus face of cathelicidin in tumorigenesis.
abstract: Cathelicidin is a host defense peptide with multiple innate immunity-related functions. Recent findings indicate that cathelicidin is frequently dysregulated in human cancers where it plays a paradoxical yet dominant role in the regulation of tumor malignancy. In this review, the regulation of malignant phenotypes by cathelicidin in relation to the activation of its receptors and intracellular signaling is discussed.
authors: W K K
authors: WK
authors: Wu
authors: J J Y
authors: JJ
authors: Sung
authors: A S L
authors: AS
authors: Cheng
authors: F K L
authors: FK
authors: Chan
authors: S S M
authors: SS
authors: Ng
authors: K F
authors: KF
authors: To
authors: X J
authors: XJ
authors: Wang
authors: L
authors: L
authors: Zhang
authors: S H
authors: SH
authors: Wong
authors: J
authors: J
authors: Yu
authors: Room 707, LKS Medical Science Building, Prince of Wales Hospital, Shatin, Hong Kong. wukakei@cuhk.edu.hk.
authors: C H
authors: CH
authors: Cho
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D063646:Carcinogenesis; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000473:pathology*; D054804:Cathelicidins
chemical_list: D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins