title: Angiotensin II induces modulation of calcium channel currents in osteoblasts.
abstract: Angiotensin II (Ang II) plays a major role in the maintenance of extracellular fluid volume and blood pressure. In addition to its well-established role in circulatory homeostasis, it has been implicated in the process of bone formation. Osteoblasts play a major role in bone formation, employing intracellular Ca(2+) as a second messenger to modulate hormonal responses and as a cofactor for mineralization. Voltage-dependent Ca(2+) channels (VDCCs) mediate the influx of Ca(2+) in response to membrane depolarization. The purpose of this study was to investigate the effects of Ang II on VDCC currents in osteoblasts using a patch-clamp recording method. To our knowledge, the data presented here demonstrate for the first time that Ang II facilitates VDCCs in osteoblasts.
authors: Department of Physiology, Tokyo Dental College.
authors: Masakazu
authors: M
authors: Tazaki
authors: Takayuki
authors: T
authors: Endoh
authors: Hiroshi
authors: H
authors: Kobayashi
authors: Mai
authors: M
authors: Ohkubo
authors: Kenji
authors: K
authors: Sueishi
mesh_terms: D016475:3T3 Cells; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002113:Calcification, Physiologic / Q000187:drug effects; D015220:Calcium Channels / Q000187:drug effects*; D020013:Calcium Signaling / Q000187:drug effects*; D018929:Cell Culture Techniques; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D018408:Patch-Clamp Techniques
chemical_list: D015220:Calcium Channels; D000804:Angiotensin II