title: Quality evaluation of human serum albumin prepared by heat denaturation in Iran: an experience for developing countries.
abstract: Blood and plasma are unique resources and access to these products save life. In this study, albumin demand and surplus plasma makes it possible to use local experiences in plasma industry for preparation of albumin so plasma was heated after stabilization; afterward denatured proteins were precipitated and separated by continuous centrifuge system. The supernatant contained albumin was filtrated, diafiltrated, ultrafiltrated, formulated and pasteurized. Albumin preparation in pilot scale with heat denaturation was performed for the first time in Iran. This method using surplus plasma is recommended for all countries that have no access to plasma fractionation industry. Therefore with more attention it has potential for use in the production of safe plasma derived products and thereby it can be used as a safe product in clinic.
authors: Iranian Blood Research and Fractionation Holding Company, Tehran, Iran. Electronic address: Hkhorsandmp@yahoo.com.
authors: Hashem
authors: H
authors: Khorsand Mohammad Pour
authors: Iranian Blood Research and Fractionation Holding Company, Tehran, Iran. Electronic address: Banazadeh@yahoo.com.
authors: Soudabeh
authors: S
authors: Banazadeh
authors: Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, P.O. Box 14665-1157, Tehran, Iran. Electronic address: Aghaie.a@gmail.com.
authors: Afsaneh
authors: A
authors: Aghaie
mesh_terms: D005260:Female; D006358:Hot Temperature; D006801:Humans; D007492:Iran; D008297:Male; D010949:Plasma / Q000737:chemistry*; D011489:Protein Denaturation; D011786:Quality Control; D012709:Serum Albumin / Q000737:chemistry* / Q000302:isolation & purification*
chemical_list: D012709:Serum Albumin
keywords: Albumin; Heat denaturation; Pilot scale; Plasma