title: Prazosin for military combat-related PTSD nightmares: a critical review.
abstract: Military combat is a common trauma experience associated with posttraumatic stress disorder (PTSD). Trauma-related nightmares are a hallmark symptom of PTSD. They can be resistant to label-pharmacological PTSD treatment, and they are associated with a variety of adverse health outcomes. The purpose of this article is to review and evaluate prazosin therapy for combat-related PTSD nightmares. Consistent with available literature for all-causes PTSD nightmares, prazosin is an effective off-label option for combat-related PTSD nightmares. Future trials may further instruct use in specific combat-exposure profiles.
authors: Brian W
authors: BW
authors: Writer
authors: Eric G
authors: EG
authors: Meyer
authors: Jason E
authors: JE
authors: Schillerstrom
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000627:therapeutic use*; D003130:Combat Disorders / Q000150:complications; D004325:Dreams / Q000187:drug effects* / Q000523:psychology; D006801:Humans; D008889:Military Personnel; D011224:Prazosin / Q000627:therapeutic use*; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy* / Q000209:etiology
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D011224:Prazosin