title: Vascular risk in migraineurs: interaction of endothelial and cortical excitability factors.
abstract: BACKGROUND
  Migraine is a common primary headache disorder occurring predominantly in a young, relatively healthy population.
  
  
  RESULTS
  There is a growing literature on associations between migraine, especially migraine with aura, and ischemic stroke as well as other vascular events. Migraine as a risk factor for vascular disease and connections between migraine and endothelial, structural, and genetic risk are reviewed.
  
  
  CONCLUSIONS
  There may be an interaction between endothelial dysfunction and cortical spreading depression affecting risk. Patient education and treatment of modifiable risk factors may decrease future vascular events.
authors: Department of Neurology, University of Washington Medical Center and Harborview Medical Center, Seattle, WA, USA.
authors: Natalia
authors: N
authors: Murinova
authors: Daniel L
authors: DL
authors: Krashin
authors: Sylvia
authors: S
authors: Lucas
mesh_terms: D002561:Cerebrovascular Disorders / Q000150:complications* / Q000453:epidemiology* / Q000503:physiopathology; D013181:Cortical Spreading Depression / Q000502:physiology; D006801:Humans; D008881:Migraine Disorders / Q000150:complications* / Q000453:epidemiology* / Q000503:physiopathology; D012307:Risk Factors
keywords: coronary artery disease; endothelial dysfunction; hypercoagulable state; migraine; stroke