title: Adverse effects of the oral anticancer drug s-1: lacrimal passage impairment and specific features of corneal epitheliopathy.
abstract: We report the incidence of lacrimal passage impairment and specific features of corneal epitheliopathy as adverse effects of the oral anticancer drug S-1, and examine the relationship between the two pathologies. We conducted a retrospective chart review of 84 patients prescribed the anticancer drug S-1. The incidence of lacrimal passage impairment and corneal epitheliopathy was 8% and 6%, respectively. Three patients experienced both pathologies, demonstrating a moderate probability of both occurring in the same patient (kappa coefficient = 0.46). The findings show that lacrimal passage impairment and specific features of corneal epitheliopathy are likely to occur in the same individual as adverse effects of S-1.
authors: Department of Ophthalmology, Nikko Memorial Hospital, Muroran, Hokkaido, Japan.
authors: Ken-Ichi
authors: K
authors: Sato
authors: Department of Ophthalmology, Nikko Memorial Hospital, Muroran, Hokkaido, Japan.
authors: Shin-Ichi
authors: S
authors: Nishimura
keywords: Antineoplastic agents; adverse effects; corneal diseases.; lacrimal duct obstruction