title: SnAP reagents for the synthesis of piperazines and morpholines.
abstract: Substituted piperazines and morpholines are valuable structural motifs in biologically active compounds, but are not easily prepared by contemporary cross-coupling approaches. In this report, we introduce SnAP reagents for the transformation of aldehydes into N-unprotected piperazines and morpholines. This approach offers simple, mild conditions compatible with aromatic, heteroaromatic, aliphatic, and glyoxylic aldehydes and provides mono- and disubstituted N-heterocycles in a single step.
authors: Laboratorium für Organische Chemie, ETH Zürich , CH-8093 Zürich, Switzerland.
authors: Michael U
authors: MU
authors: Luescher
authors: Cam-Van T
authors: CV
authors: Vo
authors: Jeffrey W
authors: JW
authors: Bode