title: Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies.
abstract: Humanized mouse models have been developed and utilized in cancer research for decades. Newly developed combined immunodeficient NOD-SCID-IL2rg–/– mice are more permissive for human cells and tissue engraftment. In this review, we discuss the use of NOD-SCID-IL2rg(–/–) mice as a preclinical tool in cancer research and its potential use for individualized cancer therapies.
authors: Department of Thoracic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Electronic address: qianjunzhou@yahoo.com.
authors: Qianjun
authors: Q
authors: Zhou
authors: Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY, United States.
authors: John
authors: J
authors: Facciponte
authors: Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and SJTUSM, Shanghai, China.
authors: Min
authors: M
authors: Jin
authors: Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
authors: Qiang
authors: Q
authors: Shen
authors: Department of Thoracic Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China. Electronic address: xkliniang@hotmail.com.
authors: Qiang
authors: Q
authors: Lin
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D053631:Interleukin Receptor Common gamma Subunit / Q000172:deficiency / Q000235:genetics; D051379:Mice; D016688:Mice, Inbred NOD; D018345:Mice, Knockout; D016513:Mice, SCID; D008822:Mice, Transgenic; D009369:Neoplasms; D057285:Precision Medicine / Q000379:methods* / Q000639:trends; D023041:Xenograft Model Antitumor Assays / Q000379:methods*
chemical_list: C507942:Il2rg protein, mouse; D053631:Interleukin Receptor Common gamma Subunit