title: The relationship between advanced oxidation protein products (AOPP) and biochemical and histopathological findings in patients with nonalcoholic steatohepatitis.
abstract: OBJECTIVE
  To investigate the correlation between advanced oxidation protein products (AOPP) levels and biochemical and histopathological findings in patients with nonalcoholic steatohepatitis (NASH).
  
  
  METHODS
  Sixty biopsy-proven NASH patients and 60 individuals with ultrasonographically healthy liver (the control group) were included in the study. AOPP levels were determined in all the participants and liver histopathological examination based on liver biopsy was performed in NASH patients. The NASH activity score (NAS), hepatosteatosis, liver inflammation and fibrosis were evaluated.
  
  
  RESULTS
  Serum AOPP level was significantly higher in the NASH group than that in the control group (461.8 ± 201.9 μmol/L vs 191.7 ± 152.5 μmol/L, P < 0.001). The receiver operating characteristic (ROC) curve revealed a sensitivity of 73.3% and a specificity of 88.3% for the diagnosis of NASH with an AOPP cut-off value of 332 μmol/L (the area under ROC curve 0.88, 95% confidence interval 0.82-0.94, P < 0.01). AOPP levels were positively correlated with NAS (r = 0.27, P = 0.035), fibrosis (r = 0.27, P = 0.037) and inflammation (r = 0.34, P = 0.008), but not the grade of steatosis (r = 0.02, P = 0.83) or ballooning (r = 0.02, P = 0.55).
  
  
  CONCLUSIONS
  AOPP levels are significantly higher in patients with NASH than in those with ultrasonographically healthy liver. AOPP levels are positively correlated with biochemical and histopathological findings (NAS, liver inflammation and fibrosis), indicating that AOPP may play a role in the development of liver fibrosis and inflammation and may predict liver histopathology in NASH.
authors: Department of Gastroenterology, Faculty of Medicine, Gazi University Hospital, Ankara, Turkey.
authors: Seren
authors: S
authors: Ozenirler
authors: Gulbanu
authors: G
authors: Erkan
authors: Ceyla
authors: C
authors: Konca Degertekin
authors: Ugur
authors: U
authors: Ercin
authors: Mustafa
authors: M
authors: Cengiz
authors: Ayse
authors: A
authors: Bilgihan
authors: Guldal
authors: G
authors: Yilmaz
authors: Gulen
authors: G
authors: Akyol
mesh_terms: D000328:Adult; D062107:Advanced Oxidation Protein Products / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D016022:Case-Control Studies; D005234:Fatty Liver / Q000097:blood* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D014463:Ultrasonography
chemical_list: D062107:Advanced Oxidation Protein Products; D015415:Biomarkers
keywords: advanced oxidation protein products; fibrosis; inflammation; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis