title: Magnetic resonance lymphography of the thoracic duct after interstitial injection of gadofosveset trisodium: a pilot dosing study in a porcine model.
abstract: BACKGROUND-RATIONALE: To investigate whether interstitial injection of gadofosveset trisodium (Ablavar®, Lantheus Medical, North Billerica, MA) would be suitable for thoracic duct (TD) imaging in a pig model.
  
  
  RESULTS
  Gadofosveset trisodium alone or premixed with 10% human serum albumin (HSA) was administered intradermally in the extremities of pigs at varying doses to visualize the TD by MRI. Two blinded readers evaluated MRIs for TD visibility. The inter-observer variability for all MR imaging sessions was assessed using the Spearman rank correlation test. MR lymphography using gadofosveset trisodium premixed with HSA yielded superior visualization of the TD compared to gadofosveset trisodium alone, with a high inter-observer agreement (correlation coefficient of 0.88 (p=0.00000115)).
  
  
  CONCLUSIONS
  We demonstrate that gadofosveset trisodium (premixed with 10%HSA) can be injected intradermally in order to perform MR lymphography of the thoracic duct. Since this agent is already FDA approved for MR imaging, the off-label use of it for imaging of the thoracic duct in humans is feasible, and the approach may prove to be beneficial for patients with TD abnormalities.
authors: 1 Molecular Imaging Program , NCI, NIH, Bethesda, Maryland.
authors: Baris
authors: B
authors: Turkbey
authors: Hisataka
authors: H
authors: Kobayashi
authors: Robert F
authors: RF
authors: Hoyt
authors: Peter L
authors: PL
authors: Choyke
authors: Takahito
authors: T
authors: Nakajima
authors: Gary L
authors: GL
authors: Griffiths
authors: Marcelino
authors: M
authors: Bernardo
authors: Kristy
authors: K
authors: Rialon
authors: Steven J
authors: SJ
authors: Fishman
authors: Laureen M
authors: LM
authors: Sena
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D005682:Gadolinium / Q000008:administration & dosage*; D007091:Image Processing, Computer-Assisted; D008220:Lymphography / Q000379:methods*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000008:administration & dosage*; D010865:Pilot Projects; D013552:Swine; D013897:Thoracic Duct
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D005682:Gadolinium; C109932:gadofosveset trisodium