title: Clinical outcome of patients with stable ischaemic heart disease as compared to those with acute coronary syndromes after percutaneous coronary intervention.
abstract: OBJECTIVE
  To compare clinical outcomes after percutaneous coronary intervention (PCI) between patients with acute coronary syndromes (ACS) and those with stable ischaemic heart disease (SIHD) stratified by anatomic disease complexity (SYNTAX score).
  
  
  RESULTS
  Patient-level data from three all-comers PCI trials were pooled. Patients (n=4,204) were stratified by clinical presentation (i.e., ACS or SIHD) and by SYNTAX score (i.e., lowest vs. two highest tertiles). The major adverse cardiac event (MACE) rates of patients with low-risk SIHD (n=531) and high-risk SIHD (n=1,066) were compared with ACS patients (n=2,607), respectively. At two years, the risk of MACE was higher for high-risk SIHD patients (OR 1.34, 95% CI: 1.08-1.66) and lower for low-risk SIHD patients (OR 0.61, 95% CI: 0.43-0.87) compared with ACS patients, respectively. This difference between high-risk SIHD patients and ACS patients was primarily driven by a higher risk of myocardial infarction (OR 1.64, 95% CI: 1.21-2.21), while there was no difference for cardiac death (OR 0.77, 95% CI: 0.49-1.21) or target lesion revascularisation (OR 1.21, 95% CI: 0.91-1.62).
  
  
  CONCLUSIONS
  In this pooled analysis, the majority of patients undergoing PCI for SIHD (i.e., with SYNTAX score >8) had a higher risk of MACE than patients with ACS.
  
  
  BACKGROUND
  URL: http://www.ClinicalTrials.gov; unique identifier: NCT00297661 (Sirtax), NCT00389220 (Leaders), NCT00114972 (Resolute-AC).
authors: Department of Cardiac Intensive Care & Interventional Cardiology, Hartcentrum, Hasselt, Belgium.
authors: Pascal
authors: P
authors: Vranckx
authors: Bindu
authors: B
authors: Kalesan
authors: Giulio G
authors: GG
authors: Stefanini
authors: Vasim
authors: V
authors: Farooq
authors: Yoshinobu
authors: Y
authors: Onuma
authors: Sigmund
authors: S
authors: Silber
authors: Ton
authors: T
authors: de Vries
authors: Peter
authors: P
authors: Jüni
authors: Patrick W
authors: PW
authors: Serruys
authors: Stephan
authors: S
authors: Windecker
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000628:therapy*; D000368:Aged; D017023:Coronary Angiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D017202:Myocardial Ischemia / Q000628:therapy*; D062645:Percutaneous Coronary Intervention / Q000009:adverse effects; D012307:Risk Factors; D016896:Treatment Outcome