title: Pharmacokinetic drug-drug interaction and their implication in clinical management.
abstract: Drug-drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly-therapy, with a prevalence of 20-40%. In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.
authors: Department of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
authors: Caterina
authors: C
authors: Palleria
authors: Department of Clinical and Experimental Medicine, Division of Pharmacology, University of Pisa, Italy.
authors: Antonello
authors: A
authors: Di Paolo
authors: Department of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
authors: Chiara
authors: C
authors: Giofrè
authors: Department of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
authors: Chiara
authors: C
authors: Caglioti
authors: Azienda Sanitaria Provinciale Catanzaro, Department of Primary Care, Italy.
authors: Giacomo
authors: G
authors: Leuzzi
authors: Department of Neurology, Cosenza Hospital, Italy.
authors: Antonio
authors: A
authors: Siniscalchi
authors: Department of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
authors: Giovambattista
authors: G
authors: De Sarro
authors: Department of Health Science, School of Medicine, University of Catanzaro, Rete Regionale di Informazione Sul Farmaco, AO MaterDomini Catanzaro, Italy.
authors: Luca
authors: L
authors: Gallelli
keywords: Absorption; adverse drug reaction; distribution; drug-drug interactions; excretion; metabolism; poly-therapy