title: Natriuretic peptides in heart failure and acute coronary syndrome.
abstract: B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are the gold standard biomarkers in determining heart failure (HF) diagnosis and prognosis. These natriuretic peptides may also be useful in guiding HF management, but further studies are needed before they can be routinely recommended for that purpose. A novel natriuretic peptide biomarker, mid-regional pro atrial natriuretic peptide (MR-proANP), shows promise in determining diagnosis and prognosis in HF patients. BNP and NT-proBNP may be of use in excluding myocardial infarction and to assist in determining prognosis in acute coronary syndrome (ACS). Therapeutic implication of natriuretic peptides in ACS is unclear.
authors: Cardiology Division, Massachusetts General Hospital, Yawkey 5B, 55 Fruit Street, Boston, MA 02114, USA.
authors: Hanna K
authors: HK
authors: Gaggin
authors: Cardiology Division, Massachusetts General Hospital, Yawkey 5B, 55 Fruit Street, Boston, MA 02114, USA. Electronic address: jjanuzzi@partners.org.
authors: James L
authors: JL
authors: Januzzi
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis*; D009320:Atrial Natriuretic Factor / Q000097:blood; D006333:Heart Failure / Q000175:diagnosis*; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood; D045265:Natriuretic Peptides / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood; D011379:Prognosis
chemical_list: D045265:Natriuretic Peptides; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor
keywords: Acute coronary syndrome; BNP; Biomarkers; Cardiac markers; Heart failure; Laboratory medicine; NT-proBNP; Natriuretic peptides