title: Stimulus-responsive polymeric micelles for the light-triggered release of drugs.
abstract: Ethyl cellulose macroinitiator was firstly synthesized by direct acylation of ethyl cellulose with 2-bromopropionyl bromide in a room temperature. And a light-responsive triblock copolymer of ethyl cellulose-g-poly(2-hydroxyethyl methacrylate)-g-poly(spiropyran ether methacrylate) (EC-g-PHEMA-g-PSPMA) was prepared by atom transfer radial polymerization. The amphiphilic structure of the copolymer enabled it to aggregate into spherical micelles in aqueous solution with an average diameter of 100 nm. The micelles exhibited light-responsive performance because of the SPMA monomer. The hydrophobic side chain of PSPMA became hydrophilic under UV light, which decreased the average size of the micelles. Additionally, the diameters of the micelles can be recovered when subsequently irradiated with visible light. The loading and light-triggered release profiles of model drugs were also investigated, and results showed that the release behavior can be controlled by changing the light wavelength.
authors: State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangdong Public Laboratory of Paper Technology and Equipment, Guangzhou, China.
authors: Bin
authors: B
authors: Wang
authors: State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangdong Public Laboratory of Paper Technology and Equipment, Guangzhou, China.
authors: Kefu
authors: K
authors: Chen
authors: State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangdong Public Laboratory of Paper Technology and Equipment, Guangzhou, China.
authors: Rendang
authors: R
authors: Yang
authors: State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangdong Public Laboratory of Paper Technology and Equipment, Guangzhou, China. Electronic address: yangfei@scut.edu.cn.
authors: Fei
authors: F
authors: Yang
authors: State Key Lab of Pulp and Paper Engineering, South China University of Technology, Guangdong Public Laboratory of Paper Technology and Equipment, Guangzhou, China.
authors: Jin
authors: J
authors: Liu
mesh_terms: D016503:Drug Delivery Systems; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D015394:Molecular Structure; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties; D013501:Surface-Active Agents / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D008823:Micelles; D004364:Pharmaceutical Preparations; D011108:Polymers; D013501:Surface-Active Agents
keywords: ATRP; Drug loading; Ethyl cellulose; Light-controlled release; Light-responsive