title: Prediction and structural equation model of sertraline treatment response in Japanese patients with major depressive disorder.
abstract: OBJECTIVE
  The aim of this study was to extract the factors possibly associated with sertraline treatment response and elucidate their interactions and extent of influence.
  
  
  METHODS
  Demographic state, stress state, personality, and eight genetic polymorphisms at baseline and clinical symptoms at baseline and 8 weeks were analyzed and examined by logistic regression and a structural equation model in sertraline treatment study of 96 Japanese patients with major depressive disorder.
  
  
  RESULTS
  Non-responders were associated with higher scores of harm avoidance in Temperament and Character Inventory, higher scores (≥24) of 17-item Hamilton Rating Scale for Depression at baseline, recurrence, and 12/12 genotype of the serotonin transporter variable number of tandem repeat polymorphism in intron 2 (5HTTSTin2). When we calculated the response index using four factors extracted, the mean response index value of non-responders was significantly higher than that of responders. The symptoms at baseline, personality, recurrence, and polymorphism of 5HTTSTin2 showed significantly direct and positive influences on the symptoms at 8 weeks in our final structural equation model with a good model fit.
  
  
  CONCLUSIONS
  Considering the combination of four factors extracted may be useful for predicting a worse response to sertraline treatment and selecting different treatment other than sertraline.
authors: Department of Psychiatry, Tokyo Metropolitan Police Hospital, Tokyo, Japan; Department of Psychiatry, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa Prefecture, Japan; Kawaguchi Hospital, Kawaguchi, Saitama Prefecture, Japan.
authors: Gentaro
authors: G
authors: Nishioka
authors: Hideaki
authors: H
authors: Yashima
authors: Yuji
authors: Y
authors: Kiuchi
authors: Sumiko
authors: S
authors: Nakamura
authors: Hideto
authors: H
authors: Oyamada
authors: Masakazu
authors: M
authors: Ishii
authors: Ikuo
authors: I
authors: Kudo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D011110:Polymorphism, Genetic; D011569:Psychiatric Status Rating Scales; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*; D020080:Tandem Repeat Sequences; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline
keywords: 5HTTSTin2; major depressive disorder; personality; recurrence; sertraline treatment response; structural equation model