title: The COX-2 rs20417 polymorphism and risk of coronary artery disease: evidence from 17,621 subjects.
abstract: BACKGROUND
  The Cyclooxygenase-2 (COX-2) rs20417 polymorphism has been implicated in coronary artery disease (CAD) risk, but individually published studies have shown inconsistent results. The aim of this study was to clarify the effects of COX-2 rs20417 polymorphism on CAD risk.
  
  
  METHODS
  A systematic literature search up to October 27, 2013 was carried out in PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of retrieved articles were screened. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were analysed for co-dominant model (CC vs. GG), additive model (C vs. G), dominant model (CC+GC vs. GG), and recessive model (CC vs. GG+GC) to assess the association using fixed- or random-effect model.
  
  
  RESULTS
  We identified nine articles (10 case-control studies) that included 3,439 cases and 14,182 controls for the present meta-analysis. Significant association between COX-2 rs20417 polymorphism and risk of CAD was observed in co-dominant model (OR=0.64, 95% CI=0.43-0.95, p=0.026) and recessive model (OR=0.77, 95% CI=0.61-0.97, p=0.025). Moreover, in the subgroup analysis stratified by ethnicity, significant associations were observed in Asians (OR=0.28, 95% CI=0.13-0.61, p=0.001 for CC vs. GC+GG; OR=0.24, 95% CI=0.11-0.51, p<0.001 for CC vs. GG) but not in Caucasians.
  
  
  CONCLUSIONS
  These results suggest that COX-2 rs20417 polymorphism may contribute to CAD development, especially in Asians.
authors: Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
authors: Heng
authors: H
authors: Wang
authors: Department of Scientific Research and Education, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
authors: Yu
authors: Y
authors: Fu
authors: Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
authors: Dong
authors: D
authors: Liu
authors: Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
authors: Miao
authors: M
authors: Zhang
authors: Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
authors: Guoheng
authors: G
authors: Zhang
authors: Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
authors: Wenbin
authors: W
authors: Wu
authors: Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
authors: Shijiang
authors: S
authors: Yang
authors: Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China.
authors: Cunjiang
authors: C
authors: Li
authors: Department of Cardiothoracic Surgery, Xuzhou Central Hospital, Affiliated Hospital of Southeast University, Xuzhou, China. Electronic address: drhuizhang@163.com.
authors: Hui
authors: H
authors: Zhang
mesh_terms: D044466:Asian People; D003324:Coronary Artery Disease / Q000235:genetics*; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011110:Polymorphism, Genetic; D039781:PubMed; D012307:Risk Factors
chemical_list: D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human
keywords: COX-2; Coronary artery disease; Meta-analysis; Polymorphism; Risk