title: Effect of systemic administered zoledronic acid on osseointegration of a titanium implant in ovariectomized rats.
abstract: OBJECTIVE
  The aim of this study was to evaluate whether zoledronic acid improves post-implant osseointegration in an ovariectomized rat model.
  
  
  METHODS
  A total of 36 female Wistar rats were subdivided into three groups: control (CTRL), ovariectomized (OVX) and ovariectomized + zoledronic acid (OVX/ZOL). Both OVX and OVX/ZOL groups underwent ovariectomy procedures, while the CTRL group received a sham operation. After a 90-day waiting period following surgery, the OVX/ZOL group received a weekly intravenous injection of 0.04 mg/kg zoledronic acid over a period of 6 weeks. The CTRL and OVX groups received intravenous injections of 0.9% NaCl, and the injections were administered with a dosing schedule that was identical to that of the OVX/ZOL group. After completing the 6-week injection regimen, every group received a titanium implant that was 1.6 mm in diameter by 4 mm in length, which was placed in the proximal metaphysis of the left tibia. All of the rats were sacrificed after 60 days and the tibia bones were harvested and processed for histological evaluation.
  
  
  RESULTS
  The percentage of bone-implant contact (BIC) varied significantly between groups. Histomorphometric analysis demonstrated that BIC was significantly higher in the OVX/ZOL group than in the OVX group.
  
  
  CONCLUSIONS
  Systemic zoledronic acid improved tibial titanium implant osseointegration in an oestrogen-deficient rat model.
authors: Department of Oral and Maxillofacial Surgery, Çorlu Military Hospital, Tekirdağ 59186, Turkey. Electronic address: emredikicier@gmail.com.
authors: Emre
authors: E
authors: Dikicier
authors: Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
authors: Ümit
authors: Ü
authors: Karaçaylı
authors: Department of Prosthodontics, Çorlu Military Hospital, Tekirdağ, Turkey.
authors: Sibel
authors: S
authors: Dikicier
authors: Department of Oral and Maxillofacial Surgery, Gülhane Military Medical Academy, Ankara, Turkey.
authors: Yılmaz
authors: Y
authors: Günaydın
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D000069343:Bone-Implant Interface / Q000473:pathology; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry; D004164:Diphosphonates / Q000008:administration & dosage*; D005260:Female; D007093:Imidazoles / Q000008:administration & dosage*; D007275:Injections, Intravenous; D023421:Models, Animal; D016348:Osseointegration / Q000187:drug effects*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D014025:Titanium / Q000737:chemistry; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D015921:Dental Implants; D003764:Dental Materials; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D014025:Titanium
keywords: Implant; Osseointegration; Osteoporosis; Zoledronic acid