title: Cyclophilin A and EMMPRIN (CD147) in cardiovascular diseases.
abstract: Cyclophilin A (CyPA) is an abundantly expressed intracellular protein. It exerts a variety of functions due to its peptidyl-prolyl cis-trans isomerase (PPIase) activity. When released into the extracellular space, CyPA binds to its extracellular receptor CD147 (EMMPRIN) and thereby initiates a cascade of inflammatory processes. Recent data indicate that both extra- and intracellular CyPA significantly contribute to cardiovascular inflammation, myocardial ischaemia and reperfusion injury, and myocardial remodelling processes. Thus, CyPA appears to represent a novel target to treat vascular and myocardial inflammation.
authors: Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Otfried-Müller Str.10, Tübingen 72076, Germany.
authors: Peter
authors: P
authors: Seizer
authors: Meinrad
authors: M
authors: Gawaz
authors: Andreas E
authors: AE
authors: May
mesh_terms: D000818:Animals; D051926:Basigin / Q000276:immunology / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000276:immunology / Q000378:metabolism*; D021984:Cyclophilin A / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism
chemical_list: D051926:Basigin; D021984:Cyclophilin A
keywords: Cyclophilin A; EMMPRIN; Inflammation