title: The intake of yam (Dioscorea bulbifera Linn) attenuated the hyperglycemia and the bone fragility in female diabetic rats.
abstract: BACKGROUND
  Diabetic patients have a higher risk to osteoporotic fractures. Foods, such as yam, to oppose hyperglycemia, has been used to treatment of diabetes.
  
  
  OBJECTIVE
  The goal was assess the role of Brazilian yam (Dioscorea bulbifera) on glycemia and bone parameters of female diabetic rats.
  
  
  METHODS
  Female Wistar rats with 3 months age were allocated in three groups. Control group (C, n = 6), treated with normal fat diet. Diabetic rats treated with high-fat diet without (DM, n = 8) and with (DMY, n = 8) liofilized yam flour. After 5 weeks of the experiment, serum glucose and insulin, pancreas mass, number and area of pancreas islets were quantified. And femur parameters were analyzed by dual-energy X-ray absorptiometry (DXA) and computed tomography (CT).
  
  
  RESULTS
  Differences were considered significant if P<0.05. Diabetic groups showed lower (P < 0.05): femur and pancreas mass, area of the pancreatic islets and insulin. However, DMY showed lower (-10%, P < 0.05) concentrations of glucose to DM group. Femur, by DXA, showed lower bone mineral density, content and area in the DM group. While the DMY group showed greater (+27%, P < 0.05) radiodensity of femoral head when compared to DM group.
  
  
  CONCLUSIONS
  Brazilian yam flour supplement did not fix a defect, but alleviated the consequences of the experimental diabetic disease. It showed results to control the rise in blood glucose levels in diabetic rats, suggesting protection in oxidative agents and postpone harm in the bone.
  
  
  CONCLUSIONS
  Considering all the findings of the present study, our results suggest that yam flour does act producing benefits in the experimental diabetes.
authors: Experimental Nutrition Laboratory. College of Nutrition. Federal Fluminense University. Brazil.. thais.nutricionista@ymail.com.
authors: Thaís de Salgado
authors: Tde S
authors: Rêgo
authors: Experimental Nutrition Laboratory. College of Nutrition. Federal Fluminense University. Brazil.. thais.nutricionista@ymail.com.
authors: Louise da Silva
authors: Lda S
authors: Ash
authors: Experimental Nutrition Laboratory. College of Nutrition. Federal Fluminense University. Brazil.. thais.nutricionista@ymail.com.
authors: Letícia
authors: L
authors: Pessoa
authors: Bromatology Laboratory. College of Pharmacy. Federal Fluminense University. Niterói. Rio de Janeiro. Brazil.. thais.nutricionista@ymail.com.
authors: Márcia Barreto da Silva
authors: MB
authors: Feijó
authors: Department of Pathology and Veterinary Clinics. Veterinary Faculty. Federal Fluminense University. Brazil.. thais.nutricionista@ymail.com.
authors: Juliana
authors: J
authors: Leite
authors: Physiological Sciences Department. Institute of Biology Roberto Alcantara Gomes. State University of Rio de Janeiro. Brazil. thais.nutricionista@ymail.com.
authors: Aline de Sousa
authors: Ade S
authors: dos Santos
authors: Experimental Nutrition Laboratory. College of Nutrition. Federal Fluminense University. Brazil.. thais.nutricionista@ymail.com.
authors: Carlos Alberto Soares
authors: CA
authors: da Costa
authors: Experimental Nutrition Laboratory. College of Nutrition. Federal Fluminense University. Brazil.. thais.nutricionista@ymail.com.
authors: Gilson Teles
authors: GT
authors: Boaventura
mesh_terms: D000818:Animals; D015519:Bone Density; D001847:Bone Diseases / Q000178:diet therapy* / Q000209:etiology; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000178:diet therapy*; D027742:Dioscorea; D005260:Female; D006943:Hyperglycemia / Q000178:diet therapy* / Q000209:etiology; D051381:Rats; D017208:Rats, Wistar