title: Cardioprotective potential of biobased gold nanoparticles.
abstract: In the present investigation, the cardioprotective nature of proanthocyanidin (PAC)-synthesized gold nanoparticles (AuNPs) is addressed in detail. There was a rapid reduction of gold metal ions by PAC and the new-genre AuNPs exhibited remarkable in vitro stability both in biological and chemical solutions. Transmission electron microscopy (TEM) indicated that the newly formed nanoparticles ranged in size from 17 to 29 nm (∼24 nm). MTT assay carried out with peripheral blood mononuclear cells demonstrated the non-toxic nature of AuNPs. PAC-synthesized AuNPs showed cardioprotective action in isoproterenol-induced myocardial injury at a lowest dosage (9 mg kg(-1)). Cardiac marker enzymes and antioxidant parameters in serum and heart tissue were also measured.
authors: Nanoscience Division, Department of Zoology, Thiruvalluvar University, Vellore 632 004, India.
authors: A
authors: A
authors: Vinodhini
authors: Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600 119, India.
authors: K
authors: K
authors: Govindaraju
authors: Nanoscience Division, Department of Zoology, Thiruvalluvar University, Vellore 632 004, India. Electronic address: gsvelu@gmail.com.
authors: G
authors: G
authors: Singaravelu
authors: Department of Biochemistry, Adhiparasakthi College of Arts and Science, Kalavai 632 506, India.
authors: A Mohamed
authors: AM
authors: Sadiq
authors: Nanoscience Division, Centre for Ocean Research, Sathyabama University, Chennai 600 119, India.
authors: V Ganesh
authors: VG
authors: Kumar
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D006046:Gold / Q000494:pharmacology*; D006801:Humans; D008297:Male; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D044945:Proanthocyanidins / Q000494:pharmacology*; D017208:Rats, Wistar; D013052:Spectrometry, X-Ray Emission; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D002316:Cardiotonic Agents; D044945:Proanthocyanidins; D006046:Gold
keywords: Cardioprotection; Gold nanoparticles; Green synthesis; Proanthocyanidin (PAC)