title: Fibroblast growth factor-23 levels are associated with uric acid but not carotid intima media thickness in renal transplant recipients.
abstract: BACKGROUND
  Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD) patients. Fibroblast growth factor-23 (FGF-23) is associated with atherosclerosis and cardiovascular mortality in CKD patients and healthy subjects. However, data in renal transplant recipients (RTR) are scarce. We aimed to determine factors associated with FGF-23 and to explore its relationship to atherosclerosis.
  
  
  METHODS
  Forty-six patients and 44 controls were included. FGF-23 was measured from plasma. Carotid intima media thickness (CIMT) was evaluated ultrasonographically.
  
  
  RESULTS
  Patients had higher waist circumference (WC; 92.2 ± 14.9 vs 85.3 ± 11.0 cm; P < .05), glucose (99.8 ± 17.2 vs 90.3 ± 6.5 mg/dL; P < .01), creatinine (1.43 ± 0.6 vs 0.86 ± 0.1 mg/dL; P < .01), triglyceride (160.4 ± 58.9 vs 135.6 ± 59.8 mg/dL; P < .05), white blood cells (WBC; 7938.6 ± 2105.2 vs 6715.7 ± 1807.5 WBC/mm(3); P < .01), ferritin (217.0 ± 255.8 vs 108.3 ± 142.4 ng/mL; P < .05), uric acid (6.5 ± 1.6 vs 4.7 ± 1.3 mg/dL; P < .01), C-reactive protein (CRP; 8.2 ± 18.2 vs 5.3 ± 7.9 mg/L; P < .01), parathyroid hormone (PTH; 89.7 ± 59.2 vs 44.1 ± 16.7 pg/mL; P < .01), and alkaline phosphatase (ALP; 162.5 ± 86.6 vs 74.2 ± 21.9 U/L; P < .01). FGF-23 was higher in patients (11.7 ± 7.2 vs 9.6 ± 6.8 pg/mL; P < .05). CIMT was similar (0.58 ± 0.09 vs 0.57 ± 0.1 mm; P > .05). WC, creatinine, and uric acid were positively correlated with FGF-23, whereas albumin showed negative correlation. On multivariate analysis only creatinine and uric acid were determinants of FGF-23.
  
  
  CONCLUSIONS
  FGF-23 levels are associated with uric acid in RTR. Larger studies are needed to confirm this finding.
authors: Department of Nephrology, Marmara University School of Medicine, Pendik, Istanbul, Turkey. Electronic address: easicioglu@yahoo.com.
authors: E
authors: E
authors: Asicioglu
authors: Department of Nephrology, Marmara University School of Medicine, Pendik, Istanbul, Turkey.
authors: A
authors: A
authors: Kahveci
authors: Department of Nephrology, Marmara University School of Medicine, Pendik, Istanbul, Turkey.
authors: H
authors: H
authors: Arikan
authors: Department of Nephrology, Marmara University School of Medicine, Pendik, Istanbul, Turkey.
authors: M
authors: M
authors: Koc
authors: Department of Nephrology, Marmara University School of Medicine, Pendik, Istanbul, Turkey.
authors: S
authors: S
authors: Tuglular
authors: Department of Nephrology, Marmara University School of Medicine, Pendik, Istanbul, Turkey.
authors: C
authors: C
authors: Ozener
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000150:complications; D002318:Cardiovascular Diseases / Q000097:blood / Q000150:complications; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000097:blood* / Q000150:complications / Q000628:therapy*; D014527:Uric Acid / Q000097:blood*; D055105:Waist Circumference
chemical_list: C000717427:FGF23 protein, human; D014527:Uric Acid; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23