title: Serum levels of three angiogenic factors in systemic lupus erythematosus and their clinical significance.
abstract: Our research investigates the serum levels of three angiogenic factors in the AF family, namely, placenta growth factor (PlGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), in 54 patients with SLE (SLE group) and 28 healthy controls (normal control) through ELISA measurement. And their interrelationships were also systematically analyzed. The SLE patients were then divided into active SLE group and inactive SLE group according to the SLEDAI score. The results show that serum levels of PlGF, bFGF, and VEGF in all SLE group and active SLE group were higher than those in normal controls. Serum levels of PlGF and bFGF in inactive SLE group were higher than those in normal controls. The level of PlGF was positively correlated with VEGF in SLE patients and positive correlation is also shown in bFGF with VEGF. The levels of PlGF and VEGF in SLE patients were positively correlated with both ESR and SLEDAI score. Thus a tentative conclusion can be drawn that the serum levels of the angiogenic factors, for example, PlGF, bFGF, and VEGF, may be relevant in the pathogenesis of SLE, and the concentrations of PlGF and VEGF seem to be the markers of SLE activity.
authors: Department of Nephrology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China.
authors: Ling
authors: L
authors: Zhou
authors: Department of Nephrology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China.
authors: Guoyuan
authors: G
authors: Lu
authors: Department of Nephrology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China.
authors: Lei
authors: L
authors: Shen
authors: Department of Nephrology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China.
authors: Linfeng
authors: L
authors: Wang
authors: Department of Rheumatology, The First Affiliated Hospital of Soochow University Suzhou, Jiangsu 215006, China.
authors: Mingjun
authors: M
authors: Wang
mesh_terms: D000328:Adult; D042501:Angiogenic Proteins / Q000097:blood*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000097:blood; D042461:Vascular Endothelial Growth Factor A / Q000097:blood; D055815:Young Adult
chemical_list: D042501:Angiogenic Proteins; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2; D000072483:Placenta Growth Factor