title: The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents.
abstract: OBJECTIVE
  The role of diet glycemic index (GI) in the control of orexigenic and anorexigenic factors of the energy balance is still not clear. The present study aimed to assess whether the habitual diet, according to different GI foods, exerts influence on regulation of energy balance markers and the effects of interdisciplinary intervention in obese adolescents.
  
  
  METHODS
  A total of 55 obese adolescents, aged from 14 to 19 years, were submited to one year of interdisciplinary therapy and were divided in two groups, according to the predominant dietary pattern of food intake: high-GI group (H-GI; n = 29) and moderate/low-GI group (M/L-GI; n = 26).
  
  
  RESULTS
  The concentration of orexigenic factor AgRP (p < 0.01), visceral fat (p=0.04) and visceral/subcutaneous ratio (p = 0.03) were higher in the group of H-GI when compared with M/L-GI group. Moreover, the habitual consumption of H-GI foods was an independent predictor to explain changes in AgRP concentrations. After one year of interdisciplinary therapy, the adolescents presented significant reductions in body weight, total body fat (%), visceral and subcutaneous fat and HOMA-IR, as well as a significant increase of fat free mass (%).
  
  
  CONCLUSIONS
  Our results may suggest that habitual H-GI diet could upregulate orexigenic pathways, contributing to vicious cycle between undesirable diets, deregulates energy balance and predispose to obesity. One the other hand, one year of interdisciplinary therapy can significant improves metabolic profile and central obesity in adolescents.
authors: Universidade Federal de São Paulo. Escola Paulista de Medicina. UNIFESP-EPM. Post Graduate Program of Nutrition.. barbaradmnetto@gmail.com.
authors: Bárbara
authors: B
authors: Dal Molin Netto
authors: Universidade Federal de São Paulo. Escola Paulista de Medicina. UNIFESP-EPM. Post Graduate Program of Nutrition.. barbaradmnetto@gmail.com.
authors: Deborah Cristina
authors: DC
authors: Landi Masquio
authors: Universidade Federal de São Paulo. Escola Paulista de Medicina. UNIFESP-EPM. Post Graduate Program of Nutrition.. barbaradmnetto@gmail.com.
authors: Raquel Munhoz
authors: RM
authors: Da Silveira Campos
authors: Universidade Federal de São Paulo. Escola Paulista de Medicina. UNIFESP-EPM. Post Graduate Program of Nutrition.. barbaradmnetto@gmail.com.
authors: Priscila
authors: P
authors: De Lima Sanches
authors: Universidade Federal de São Paulo. Escola Paulista de Medicina. UNIFESP-EPM. Post Graduate Program of Nutrition.. barbaradmnetto@gmail.com.
authors: Flavia
authors: F
authors: Campos Corgosinho
authors: Weigth Science. Brazil.. barbaradmnetto@gmail.com.
authors: Lian
authors: L
authors: Tock
authors: Post Graduate Program of Nutrition.. barbaradmnetto@gmail.com.
authors: Lila
authors: L
authors: Missae Oyama
authors: Universidade Federal de São Paulo. Escola Paulista de Medicina. UNIFESP-EPM. Post Graduate Program of Nutrition. Department of Psychobiology.. barbaradmnetto@gmail.com.
authors: Marco
authors: M
authors: Túlio de Mello
authors: Universidade Federal de São Paulo. Escola Paulista de Medicina. UNIFESP-EPM. Department of Psychobiology.. barbaradmnetto@gmail.com.
authors: Sergio
authors: S
authors: Tufik
authors: Universidade Federal de São Paulo. Escola Paulista de Medicina. UNIFESP-EPM. Post Graduate Program of Nutrition. Biosciences Department. Post Graduate Program of Interdisciplinary Health Sciences(UNIFESP-EPM).. barbaradmnetto@gmail.com.
authors: Ana Raimunda
authors: AR
authors: Dâmaso
mesh_terms: D000293:Adolescent; D054369:Agouti-Related Protein / Q000378:metabolism*; D004032:Diet; D004435:Eating; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D038321:Glycemic Index; D006801:Humans; D008297:Male; D009765:Obesity / Q000378:metabolism*; D055815:Young Adult
chemical_list: D054369:Agouti-Related Protein