title: [Two cases of optic neuritis in children with rapid thinning of the ganglion cell complex].
abstract: BACKGROUND
  There are many reports regarding the circumpapillary retinal nerve fiber layer (cpRNFL) in optic neuritis (ON). However, few studies of changes over time in the ganglion cell complex (GCC) have been reported. As far as we know, no studies of such changes in children have been reported. In the present study, we report two patients with pediatric ON in which the time course of GCC and cpRNFL were observed using optical coherence tomography.
  
  
  METHODS
  Two cases, one 9-year-old boy and one 11-year-old boy. The two patients showed acute visual impairment, relative afferent pupillary defect, and swelling of the optic disc, leading to the diagnosis of ON. Regardless of whether visual function was improved after steroid pulse therapy, thinning of the GCC and cpRNFL progressed rapidly over time.
  
  
  CONCLUSIONS
  Atrophy of the retinal inner layer in the macula occurred soon after the onset of ON. Although the inflammation was reduced after treatment, atrophy of the ganglion cells continuted to progress. GCC thickness measurement in pediatric ON is useful for pathological assessment and followup, because we can detect atrophy of the ganglion cells and retinal nerve fibers soon after onset.
authors: Department of Ophthalmology, Kawasaki Medical School, Okayama-ken, Japan. ort@med.kawasaki-m.ac.jp
authors: Katsutoshi
authors: K
authors: Goto
authors: Department of Ophthalmology, Kawasaki Medical School, Okayama-ken, Japan.
authors: Kenichi
authors: K
authors: Mizukawa
authors: Department of Ophthalmology, Kawasaki Medical School, Okayama-ken, Japan.
authors: Atsushi
authors: A
authors: Miki
authors: Department of Ophthalmology, Kawasaki Medical School, Okayama-ken, Japan.
authors: Tsutomu
authors: T
authors: Yamashita
authors: Department of Ophthalmology, Kawasaki Medical School, Okayama-ken, Japan.
authors: Syunsuke
authors: S
authors: Araki
authors: Department of Ophthalmology, Kawasaki Medical School, Okayama-ken, Japan.
authors: Junichi
authors: J
authors: Kiryu
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D008297:Male; D009412:Nerve Fibers / Q000473:pathology*; D009898:Optic Disk / Q000473:pathology* / Q000503:physiopathology; D009900:Optic Nerve / Q000473:pathology*; D009902:Optic Neuritis / Q000473:pathology* / Q000503:physiopathology; D012160:Retina / Q000473:pathology; D012165:Retinal Ganglion Cells / Q000473:pathology*; D013997:Time Factors