title: Xerophthalmia--a potential epidemic on our doorstep?
abstract: OBJECTIVE
  Xerophthalmia refers to the ocular manifestations associated with vitamin A deficiency, including xerosis, keratomalacia, nyctalopia and Bitot's spot. Hypovitaminosis A is well-recognised in developing countries, but is rare in the developed world. Most cases in the latter relate to fat malabsorption. Conditions in which vitamin A metabolism or storage is deranged (chronic liver disease, including alcoholism) are also aetiologies. We wanted to see whether this was common in our department.
  
  
  METHODS
  Oral vitamin A supplements were given to patients who presented with hypovitaminosis A.
  
  
  RESULTS
  All patients were found to have hypovitaminosis A on biochemical testing and responded dramatically to oral vitamin A supplementation, resulting in an improved final visual outcome.
  
  
  CONCLUSIONS
  This series demonstrates that prompt recognition and treatment of xerophthalmia can lead to rapid recovery and avert significant visual morbidity. The prevalence of xerophthalmia is likely to increase in the developed world largely owing to alcoholic liver disease. It is thought by some that we are on the verge of a potential epidemic. We hope that by increasing the profile of this important public health issue, we may be able to influence future prevalence of hypovitaminosis.
authors: Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK.
authors: S
authors: S
authors: McLaughlin
authors: Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK.
authors: J
authors: J
authors: Welch
authors: Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK.
authors: E
authors: E
authors: MacDonald
authors: Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK.
authors: S
authors: S
authors: Mantry
authors: Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK.
authors: K
authors: K
authors: Ramaesh
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014801:Vitamin A / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014815:Vitamins / Q000627:therapeutic use; D014985:Xerophthalmia / Q000188:drug therapy / Q000209:etiology*
chemical_list: D014815:Vitamins; D014801:Vitamin A