title: Tortuosenes A and B, new diterpenoid metabolites from the Formosan soft coral Sarcophyton tortuosum.
abstract: Tortuosenes A and B (1 and 2), possessing new diterpenoid molecular structures, were isolated from the Formosan soft coral Sarcophyton tortuosum along with a known cembrane, emblide (3). The structures of 1 and 2 were established by extensive spectroscopic analysis, and the absolute configuration of 1 was determined by TDDFT ECD calculations. Tortuosene A was found to display significant inhibitory effects on the generation of the superoxide anion in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced neutrophils.
authors: Department of Marine Biotechnology and Resources, National Sun Yat-sen University , Kaohsiung 804, Taiwan.
authors: Kuan-Hua
authors: KH
authors: Lin
authors: Yen-Ju
authors: YJ
authors: Tseng
authors: Bo-Wei
authors: BW
authors: Chen
authors: Tsong-Long
authors: TL
authors: Hwang
authors: Hsing-Yin
authors: HY
authors: Chen
authors: Chang-Feng
authors: CF
authors: Dai
authors: Jyh-Horng
authors: JH
authors: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D013481:Superoxides / Q000378:metabolism; D013624:Taiwan
chemical_list: D004224:Diterpenes; C000588636:tortuosene A; C000588637:tortuosene B; D013481:Superoxides; C037071:cembrane; D009240:N-Formylmethionine Leucyl-Phenylalanine