title: [Safe prescription recommendations for non steroidal anti-inflammatory drugs: Consensus document ellaborated by nominated experts of three scientific associations (SER-SEC-AEG)].
abstract: This article outlines key recommendations for the appropriate prescription of non steroidal anti-inflammatory drugs to patients with different musculoskeletal problems. These recommendations are based on current scientific evidence, and takes into consideration gastrointestinal and cardiovascular safety issues. The recommendations have been agreed on by experts from three scientific societies (Spanish Society of Rheumatology [SER], Spanish Association of Gastroenterology [AEG] and Spanish Society of Cardiology [SEC]), following a two-round Delphi methodology. Areas that have been taken into account encompass: efficiency, cardiovascular risk, gastrointestinal risk, liver risk, renal risk, inflammatory bowel disease, anemia, post-operative pain, and prevention strategies. We propose a patient management algorithm that summarizes the main aspects of the recommendations.
authors: Servicio de Aparato Digestivo, Hospital Clínico Lozano Blesa, Universidad de Zaragoza, IIS Aragón, CIBERehd, Zaragoza, España. Electronic address: alanas@unizar.es.
authors: Angel
authors: A
authors: Lanas
authors: Servicio de Reumatología, Hospital del Mar, Universidad Autónoma de Barcelona, Barcelona, España.
authors: Pere
authors: P
authors: Benito
authors: Servicio de Cardiología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, España.
authors: Joaquín
authors: J
authors: Alonso
authors: i+D+I, Unidad de Gestión Clínica de Reumatología, Servicio de Reumatología, Hospital Universitario Virgen Macarena, Sevilla, España.
authors: Blanca
authors: B
authors: Hernández-Cruz
authors: Servicio de Cardiología, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Sevilla, España.
authors: Gonzalo
authors: G
authors: Barón-Esquivias
authors: Unidad de Digestivo, Agencia Sanitaria Costa del Sol, Marbella, Málaga, España.
authors: Angeles
authors: A
authors: Perez-Aísa
authors: Servei de Digestiu, Hospital de Sabadell, Universidad Autónoma de Barcelona, CIBERehd, Sabadell, Barcelona, España.
authors: Xavier
authors: X
authors: Calvet
authors: Unidad de Reumatología, Hospital de Tortosa, Tortosa, Tarragona, España.
authors: José Francisco
authors: JF
authors: García-Llorente
authors: Unidad de Investigación, Sociedad Española de Reumatología, Madrid, España.
authors: Milena
authors: M
authors: Gobbo
authors: Servicio de Cardiología y Unidad Coronaria, Hospital Clínico Universitario, Santiago de Compostela, La Coruña, España.
authors: José R
authors: JR
authors: Gonzalez-Juanatey
mesh_terms: D000367:Age Factors; D000465:Algorithms; D000740:Anemia / Q000139:chemically induced / Q000517:prevention & control; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000139:chemically induced / Q000517:prevention & control; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000517:prevention & control; D004347:Drug Interactions; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D015201:Meta-Analysis as Topic; D010149:Postoperative Pain / Q000188:drug therapy; D010437:Peptic Ulcer / Q000139:chemically induced / Q000517:prevention & control; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D011788:Quality of Life; D012216:Rheumatic Diseases / Q000188:drug therapy; D018570:Risk Assessment
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors
keywords: Adverse event; Anti-inflamatorios no esteroideos; Cardiovascular; Efecto adverso; Gastrointestinal hemorrhage; Hemorragia gastrointestinal; Non steroidal anti-inflammatory drugs; Peptic ulcer; Úlcera péptica