title: Cardiovascular sequelae in long-term survivors of young peoples' cancer: a linked cohort study.
abstract: BACKGROUND
  We aimed to define the incidence and risk of cardiovascular late effects (LEs) identified from inpatient hospital episode statistics (HES) among long-term survivors of cancer in young people by age at diagnosis (0-14 and 15-29 years).
  
  
  METHODS
  Records from the Yorkshire Specialist Register of Cancer in Children and Young People (1991-2006) were linked to inpatient HES data (1996-2011) to assess rates of cardiovascular LEs. Rates were compared with the general population in Yorkshire using age-sex-matched HES records for the entire region.
  
  
  RESULTS
  Of 3247 survivors of cancer, 3.6% had at least one cardiovascular LE. Overall, cardiovascular hospitalisations for the childhood cohort were threefold higher compared with the general population, but did not differ for young adults. For young adults, increased rates were limited to pericardial disease, cardiomyopathy and heart failure, pulmonary heart disease, hypertension and conduction disorders.
  
  
  CONCLUSIONS
  Survivors of childhood and young adult cancer remain at increased risk of cardiovascular LEs compared with the general population.
authors: Division of Epidemiology and Biostatistics, University of Leeds, Room 8.49, Worlsey Building, Clarendon Way, Leeds LS2 9NL, UK.
authors: M
authors: M
authors: van Laar
authors: Division of Epidemiology and Biostatistics, University of Leeds, Room 8.49, Worlsey Building, Clarendon Way, Leeds LS2 9NL, UK.
authors: R G
authors: RG
authors: Feltbower
authors: 1] Division of Epidemiology and Biostatistics, University of Leeds, Room 8.49, Worlsey Building, Clarendon Way, Leeds LS2 9NL, UK [2] Department of Cardiology, York Teaching Hospital NHS Foundation Trust, Wigginton Road, York YO31 8HE, UK.
authors: C P
authors: CP
authors: Gale
authors: St James's Institute of Oncology, Leeds Teaching Hospitals NHS Trust, Bexley Wing, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.
authors: D T
authors: DT
authors: Bowen
authors: 1] Department of Health Sciences, University of York and the Hull York Medical School, Seebohm Rowntree Building, Heslington, York YO10 5DD, UK [2] Public Health England Knowledge and Intelligence Team (Northern and Yorkshire), Leeds Teaching Hospitals NHS Trust, Level 6, Bexley Wing, St James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.
authors: S E
authors: SE
authors: Oliver
authors: Regional Department of Paediatric Oncology and Haematology, Leeds Teaching Hospitals NHS Trust, Leeds General Infirmary, Great George Street, Leeds LS1 3EX, UK.
authors: A
authors: A
authors: Glaser
mesh_terms: D000293:Adolescent; D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000453:epidemiology*; D012306:Risk; D017741:Survivors / Q000706:statistics & numerical data; D055815:Young Adult