title: Acetaminophen intoxication is associated with decreased serum paraoxonase and arylesterase activities and increased lipid hydroperoxide levels.
abstract: BACKGROUND
  Acetaminophen is at present one of the most commonly used analgesics and antipyretics. Recent evidence has suggested that oxidative stress is involved in the mechanism of acetaminophen intoxication. Paraoxonase-1 (PON1) plays an important role as an endogenous free-radical scavenging molecule. The aim of this study was to evaluate the influence of serum PON1 activity and oxidative stress in patients with acetaminophen intoxication.
  
  
  METHODS
  A total of 20 patients with acetaminophen intoxication and 25 healthy controls were enrolled. Serum total antioxidant capacity (TAC), lipid hydroperoxide (LOOH) levels, and paraoxonase and arylesterase activities were measured spectrophotometrically.
  
  
  RESULTS
  The serum TAC levels and the paraoxonase and arylesterase activities were significantly lower in patients with acetaminophen intoxication compared with controls (all, p < 0.001), while the serum LOOH levels were significantly higher (p < 0.001).
  
  
  CONCLUSIONS
  Our results suggest that decreased PON1 activity seems to be associated with increased oxidative stress in patients with acetaminophen intoxication. Measuring serum PON1 activity may be useful in assessing the development of toxicity risk in acetaminophen toxicity. It would be useful to recommend vitamins with antioxidant effects such as vitamins C and E along with medical treatments.
authors: Department of Emergency Medicine, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
authors: S
authors: S
authors: Karadas
authors: Department of Internal Medicine, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey m.aslan301@mynet.com.
authors: M
authors: M
authors: Aslan
authors: Department of Emergency Medicine, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
authors: H
authors: H
authors: Gonullu
authors: Department of Emergency Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors: C
authors: C
authors: Kati
authors: Department of Emergency Medicine, Ondokuz Mayis University, Samsun, Turkey.
authors: L
authors: L
authors: Duran
authors: Department of Gastroenterology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
authors: S
authors: S
authors: Olmez
authors: Department of Internal Medicine, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
authors: M E
authors: ME
authors: Kucukoglu
authors: Department of Chemistry, Faculty of Science and Arts, Yuzuncu Yil University, Van, Turkey.
authors: H
authors: H
authors: Demir
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D058633:Antipyretics / Q000633:toxicity*; D043303:Aryldialkylphosphatase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D055815:Young Adult
chemical_list: D018712:Analgesics, Non-Narcotic; D058633:Antipyretics; D008054:Lipid Peroxides; D000082:Acetaminophen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
keywords: Acetaminophen intoxication; PON1 activity; oxidative stress; total antioxidant capacity