title: Intra-molecular reactions as a new approach to investigate bio-radical reactivity: a case study of cysteine sulfinyl radicals.
abstract: Herein, we demonstrated the use of gas-phase intra-molecular reactions facilitated by collisional activation to investigate bi-molecular reactions with inherent low reactivity. Reactions between sulfinyl radicals (-SO˙) toward free thiol (-SH) were employed as a model system. A new reaction channel, i.e. sulfinyl exchange with thiol, was observed under beam-type collision-induced dissociation (CID), which was not detectable from traditional ion/molecule reactions.
authors: Department of Chemistry, Purdue University, West Lafayette, IN 47907-2084, USA. yxia@purdue.edu.
authors: Kirt L
authors: KL
authors: Durand
authors: Xiaoxiao
authors: X
authors: Ma
authors: Yu
authors: Y
authors: Xia
mesh_terms: D000595:Amino Acid Sequence; D003545:Cysteine / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry*; D005740:Gases / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D013058:Mass Spectrometry; D010455:Peptides / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D005609:Free Radicals; D005740:Gases; D007477:Ions; D010455:Peptides; D013438:Sulfhydryl Compounds; D003545:Cysteine