title: NAD+ deficiency in age-related mitochondrial dysfunction.
abstract: Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study (Gomes et al., 2013) shows that reduced levels of nicotinamide adenine dinucleotide (NAD(+)) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.
authors: Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA. Electronic address: taprolla@facstaff.wisc.edu.
authors: Tomas A
authors: TA
authors: Prolla
authors: Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA.
authors: John M
authors: JM
authors: Denu
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D010085:Oxidative Phosphorylation
chemical_list: D009243:NAD