title: Two rare cases of benign hyperlipasemia in children.
abstract: Gullo's syndrome is a newly identified condition characterized by a chronic elevation of pancreatic amylase and/or lipase in the absence of pancreatic disease. Until now, only one case of benign isolated hyperlipasemia in children has been recorded. We describe two children with benign and not familial increase of serum lipase. Case 1: a six year old girl presented with occasional discovery of serum lipase elevation. Medical history was silent for pancreatic hyperenzymemia. The screening for possible causes for elevated lipase (genetic, autoimmune and infectious diseases) was normal. The serum lipase increased three fold over the upper limit (193 U/L; reference range 0-60 U/L), with daily fluctuation of values. Both ultrasound scan and magnetic resonance imaging were normal. The genetic mutation associated with chronic pancreatitis was negative. We followed up this patient for two years with blood tests every six months and she did not show any signs or symptoms of pancreatic disease, except for the high level of lipase serum. Case 2: an eight year old girl complained of nausea, vomiting and severe abdominal pain in the epigastric region after eating for the last two weeks. Full blood count, electrolytes, C-reactive protein, liver and renal function were normal. Serum lipase was 96 U/L (reference range 0-60 U/L). The screening for the possible causes of pancreatic disease was negative. Endoscopy of the upper gastrointestinal tract, ultrasound, computed tomography scan and magnetic resonance imaging were normal. One year after the presentation of the symptoms, the patient became asymptomatic although the level of serum lipase continued to be high.
authors: Elena Lionetti, Salvatore Leonardi, Stefania Tomarchio, Alessia Gennaro, Chiara Franzonello, Mario La Rosa, Department of Medical and Pediatric Science, University of Catania, 95123 Catania, Italy.
authors: Elena
authors: E
authors: Lionetti
authors: Elena Lionetti, Salvatore Leonardi, Stefania Tomarchio, Alessia Gennaro, Chiara Franzonello, Mario La Rosa, Department of Medical and Pediatric Science, University of Catania, 95123 Catania, Italy.
authors: Ruggiero
authors: R
authors: Francavilla
authors: Elena Lionetti, Salvatore Leonardi, Stefania Tomarchio, Alessia Gennaro, Chiara Franzonello, Mario La Rosa, Department of Medical and Pediatric Science, University of Catania, 95123 Catania, Italy.
authors: Salvatore
authors: S
authors: Leonardi
authors: Elena Lionetti, Salvatore Leonardi, Stefania Tomarchio, Alessia Gennaro, Chiara Franzonello, Mario La Rosa, Department of Medical and Pediatric Science, University of Catania, 95123 Catania, Italy.
authors: Stefania
authors: S
authors: Tomarchio
authors: Elena Lionetti, Salvatore Leonardi, Stefania Tomarchio, Alessia Gennaro, Chiara Franzonello, Mario La Rosa, Department of Medical and Pediatric Science, University of Catania, 95123 Catania, Italy.
authors: Alessia
authors: A
authors: Gennaro
authors: Elena Lionetti, Salvatore Leonardi, Stefania Tomarchio, Alessia Gennaro, Chiara Franzonello, Mario La Rosa, Department of Medical and Pediatric Science, University of Catania, 95123 Catania, Italy.
authors: Chiara
authors: C
authors: Franzonello
authors: Elena Lionetti, Salvatore Leonardi, Stefania Tomarchio, Alessia Gennaro, Chiara Franzonello, Mario La Rosa, Department of Medical and Pediatric Science, University of Catania, 95123 Catania, Italy.
authors: Mario La
authors: ML
authors: Rosa
keywords: Amylase; Benign hyperlipasemia; Gullo’s syndrome; Lipase; Pancreatic hyperenzymemia