title: The value of substratified combined imaging assessment with mammography and ultrasonography for Chinese women with palpable breast masses.
abstract: A 5-point breast imaging classification modified from the seven-category Breast Imaging-Reporting and Data System has been applied for mammographic and ultrasonographic examinations in patients with palpable breast masses. The aim of this study was to confirm the value of combined imaging assessment. We included 5,296 cases (3,002 benign and 2,294 cancer) from January 2004 to December 2011. Ultrasonography showed a significantly (P < 0.01) higher sensitivity and specificity and lower false-negative rate and false-negative predictive value (false-NPV) than mammography. The sensitivity of combined imaging was significantly (P < 0.01) increased and the false-negative rate and false-NPV were significantly (P < 0.01) reduced compared to mammography or ultrasonography alone. However, the specificity was significantly (P < 0.01) declined for combined imaging versus mammography or ultrasonography alone. Compared with combined imaging assessment, a significant (P < 0.01) improvement was noted with substratified scoring, with increased specificity and false-negative rate and decreased sensitivity. In conclusion, the substratified combined imaging score has the potential to provide additional value in the workup of palpable breast lesions.
authors: Breast Division, The First Affiliated Hospital of China Medical University, China Medical University Cancer Institute, Shenyang, 110001, People's Republic of China, jgli@mail.cmu.edu.cn.
authors: Jiguang
authors: J
authors: Li
authors: Peng
authors: P
authors: Xing
authors: Liang
authors: L
authors: Feng
authors: Huiting
authors: H
authors: Dong
authors: Feng
authors: F
authors: Jin
authors: Yunfei
authors: Y
authors: Wu
authors: Xinyu
authors: X
authors: Zheng
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary / Q000379:methods*