title: Pyrrolidine-mediated direct preparation of (e)-monoarylidene derivatives of homo- and heterocyclic ketones with various aldehydes.
abstract: An efficient method for the facile synthesis of (E)-monoarylidene derivatives of homo- and heterocyclic ketones with various aldehydes in the presence of a pyrrolidine organocatalyst has been achieved. A range of α,β-unsaturated ketones were obtained in moderate to high yields (up to 99%). Unlike the Claisen-Schmidt condensation process, the formation of undesired bisarylidene byproducts is not observed. The possible reaction mechanism suggests that the reaction proceeds via a Mannich-elimination sequence.
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. xingu2014@yeah.net.
authors: Xin
authors: X
authors: Gu
authors: Analytical & Testing Center, Sichuan University, Chengdu 610064, China. wangxiaoyan@scu.edu.cn.
authors: Xiaoyan
authors: X
authors: Wang
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. ftwang2014@163.com.
authors: Fengtian
authors: F
authors: Wang
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. hongbaosun88@gmail.com.
authors: Hongbao
authors: H
authors: Sun
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. liujie2011@scu.edu.cn.
authors: Jie
authors: J
authors: Liu
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. xieym@scu.edu.cn.
authors: Yongmei
authors: Y
authors: Xie
authors: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China. mlxiang123@163.com.
authors: Mingli
authors: M
authors: Xiang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D007659:Ketones; D011759:Pyrrolidines; C032519:pyrrolidine