title: Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010.
abstract: This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9%), 19 F (12.1%), and 6B (8.6%). Between 2006 and 2010, PCV7 serotypes decreased from 62.5% to 21.4% (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8% to 42.9% (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2% to 21.7% (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4% to 47.8% (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased.
authors: Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Chungnam National University Hospital, Daejeon, Republic of Korea.
authors: Eun Young
authors: EY
authors: Cho
authors: Department of Pediatrics, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea.
authors: Hyunju
authors: H
authors: Lee
authors: Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors: Eun Hwa
authors: EH
authors: Choi
authors: Department of Pediatrics, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea.
authors: Yae-Jean
authors: YJ
authors: Kim
authors: Department of Pediatrics, Eulji University School of Medicine, Eulji General Hospital, Seoul, Republic of Korea.
authors: Byung Wook
authors: BW
authors: Eun
authors: Department of Internal Medicine, Gachon University School of Medicine, Gachon University Gil Hospital, Incheon, Republic of Korea.
authors: Yong Kyun
authors: YK
authors: Cho
authors: Department of Pediatrics, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, Republic of Korea.
authors: Yun-Kyung
authors: YK
authors: Kim
authors: Department of Pediatrics, Chonbuk National University Medical School, Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors: Dae Sun
authors: DS
authors: Jo
authors: Department of Laboratory Medicine, Chonbuk National University Medical School, Chonbuk National University Hospital, Jeonju, Republic of Korea.
authors: Hye Soo
authors: HS
authors: Lee
authors: Department of Pediatrics, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
authors: Jina
authors: J
authors: Lee
authors: Department of Laboratory Medicine, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
authors: Mi-Na
authors: MN
authors: Kim
authors: Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Republic of Korea.
authors: Dong Soo
authors: DS
authors: Kim
authors: Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address: hoanlee@snu.ac.kr.
authors: Hoan Jong
authors: HJ
authors: Lee
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D005260:Female; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D006801:Humans; D007223:Infant; D008297:Male; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control*; D022242:Pneumococcal Vaccines / Q000008:administration & dosage*; D015995:Prevalence; D056910:Republic of Korea / Q000453:epidemiology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification* / Q000302:isolation & purification
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines
keywords: Antimicrobial resistance; Pneumococcal vaccines; Serotype; Streptococcus pneumoniae