title: Feasibility of cell therapy in multiple sclerosis: a systematic review of 83 studies.
abstract: Multiple Sclerosis is an inflammatory disease of the central nervous system in which T cells experience a second phase of activation, which ultimately leads to axonal demyelination and neurological disability. The recent advances in stem cell therapies may serve as potential treatments for neurological disorders. There are broad types of stem cells such as neural, embryonic, mesenchymal and hematopoietic stem cells with unprecedented hope in treating many debilitating diseases. In this paper we will review the substantial literature regarding experimental and clinical use of these stem cells and possible mechanisms in the treatment of MS. These results may pave the road for the utilization of stem cells for the treatment of MS.
authors: Stem Cell Biology Department, Stem Cell Technology Research Center, Tehran, Iran.
authors: Abdolreza
authors: A
authors: Ardeshiry Lajimi
authors: Division of Laboratory Hematology and Blood Banking, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors: Majid Farshdousti
authors: MF
authors: Hagh
authors: Research Center of Thalassemia & Hemoglobinopathy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors: Najmaldin
authors: N
authors: Saki
authors: Division of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands.
authors: Esmaeil
authors: E
authors: Mortaz
authors: Hematology Department, Faculty of Medical Science, Tarbiat modares University, Tehran, Iran.
authors: Masoud
authors: M
authors: Soleimani
authors: Toxicology Research Center, Ahvaz Jundishapur, University of Medical Sciences, Ahvaz, Iran.
authors: Fakher
authors: F
authors: Rahim
keywords: Hematopoietic stem cells; Human embryonic stem cells; Mesenchymal stem cells; Multiple sclerosis; Neural stem cells; Stem cells therapy