title: Magnesium attenuates carbon tetrachloride-induced hepatic injury in rats.
abstract: In the present study, we investigated the protective effects of magnesium sulfate (MgSO4) against carbon tetrachloride (CCl4)-induced liver damage in rats. MgSO4 (0.001, 0.01, 0.05 and 0.1 Mg(2+) g/kg b.wt.) was administered intragastrically for 28 consecutive days to male, CCl4-treated rats. The hepatoprotective activity was assessed using various biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), γ-glutamyltransferase (GGT) and superoxide dismutase (SOD) activity. Histopathological changes in the liver, of different groups were also studied. Administration of CCl4 increased serum ALT, AST, ALP and GGT, but decreased liver SOD activities in rats. Treatment with MgSO4 significantly attenuated these changes to nearly normal levels. The animals treated with MgSO4 showed decreased necrotic zones and reduced hepatocellular degeneration when compared to liver exposed to CCl4 alone. Hepatic damage was reduced in MgSO4-treated rats. Thus, our results suggest that MgSO4 has potential for the treatment of liver damage resulting from chemical intoxication.
authors: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors: Akram
authors: A
authors: Eidi
authors: Department of Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors: Pejman
authors: P
authors: Mortazavi
authors: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors: Farhad
authors: F
authors: Moradi
authors: Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors: Ali Haeri
authors: AH
authors: Rohani
authors: Department of Clinical Pathology, Faculty of Specialized Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran.
authors: Shahabeddin
authors: S
authors: Safi
mesh_terms: D000818:Animals; D002251:Carbon Tetrachloride; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy* / Q000473:pathology; D008278:Magnesium Sulfate / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D015430:Weight Gain / Q000187:drug effects
chemical_list: D008278:Magnesium Sulfate; D002251:Carbon Tetrachloride
keywords: carbon tetrachloride; hepatoprotection; magnesium sulfate; rat