title: Current progress in gene delivery technology based on chemical methods and nano-carriers.
abstract: Gene transfer methods are promising in the field of gene therapy. Current methods for gene transfer include three major groups: viral, physical and chemical methods. This review mainly summarizes development of several types of chemical methods for gene transfer in vitro and in vivo by means of nano-carriers like; calcium phosphates, lipids, and cationic polymers including chitosan, polyethylenimine, polyamidoamine dendrimers, and poly(lactide-co-glycolide). This review also briefly introduces applications of these chemical methods for gene delivery.
authors: 1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors: Lian
authors: L
authors: Jin
authors: 2. Nanjing Maternal and Child Health Medical Institute, Nanjing Maternal and Child Health Hospital Affiliated of Nanjing Medical University, Nanjing 210029, China.
authors: Xin
authors: X
authors: Zeng
authors: 1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
authors: Ming
authors: M
authors: Liu
authors: 1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China ; 3. Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province, Hunan Key Laboratory of Green Packaging and Biomedical Nanotechnology, Hunan University of Technology, Zhuzhou 412007, China.
authors: Yan
authors: Y
authors: Deng
authors: 1. State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China ; 3. Economical Forest Cultivation and Utilization of 2011 Collaborative Innovation Center in Hunan Province, Hunan Key Laboratory of Green Packaging and Biomedical Nanotechnology, Hunan University of Technology, Zhuzhou 412007, China.
authors: Nongyue
authors: N
authors: He
mesh_terms: D000818:Animals; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry
chemical_list: D008081:Liposomes; D011108:Polymers
keywords: Chemical Methods.; Gene delivery; Non-viral; Vectors