title: Signal regulatory protein alpha is present in several neutrophil granule populations and is rapidly mobilized to the cell surface to negatively fine-tune neutrophil accumulation in inflammation.
abstract: Signal regulatory protein alpha (SIRPα) is a cell surface glycoprotein with inhibitory functions, which may regulate neutrophil transmigration. SIRPα is mobilized to the neutrophil surface from specific granules, gelatinase granules, and secretory vesicles following inflammatory activation in vitro and in vivo. The lack of SIRPα signaling and the ability to upregulate SIRPα to the cell surface promote neutrophil accumulation during inflammation in vivo.
authors: Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.
authors: Åsa
authors: Å
authors: Stenberg
authors: Anna
authors: A
authors: Karlsson
authors: Elisabeth
authors: E
authors: Feuk-Lagerstedt
authors: Karin
authors: K
authors: Christenson
authors: Johan
authors: J
authors: Bylund
authors: Anna
authors: A
authors: Oldenborg
authors: Liselotte
authors: L
authors: Vesterlund
authors: Takashi
authors: T
authors: Matozaki
authors: Janove
authors: J
authors: Sehlin
authors: Per-Arne
authors: PA
authors: Oldenborg
mesh_terms: D000328:Adult; D000943:Antigens, Differentiation / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015550:Cell Degranulation / Q000235:genetics; D002462:Cell Membrane / Q000378:metabolism*; D002478:Cells, Cultured; D025461:Feedback, Physiological; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000235:genetics; D009504:Neutrophils / Q000276:immunology*; D021381:Protein Transport; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D022142:Secretory Vesicles / Q000378:metabolism*
chemical_list: D000943:Antigens, Differentiation; D011971:Receptors, Immunologic; C501920:SIRPA protein, human