title: Experimental treatment of radiation pneumonitis with human umbilical cord mesenchymal stem cells.
abstract: OBJECTIVE
  To evaluate of the curative effect of human umbilical cord mesenchymal stem cells (hUC-MSCs) on rat acute radiation pneumonitis.
  
  
  METHODS
  Fourty rats were randomly divided into control group, radiation group, stem cell prevention group, stem cell treatment group and prednisone treatment group. All rats except those in the control group were radiated with X ray to establish the acute radiation pneumonitis damage model. The hUC-MSCs cultured in vitro was administrated to the rats of the prevention group via tail vein (1×10(6) cells/kg BW) 24 h before the radiation, while the same administration was performed in the rats of the treatment group 24 h after the radiation. After 24 h post the radiation, the rats in the radiation group were given 0.4 mL physiological saline, and those in the prednisone group were given 1 mg/kg prednisone. All rats were observed and executed 72 h after the radiation to detect lung histological changes.
  
  
  RESULTS
  After the administration of hUC-MSCs, the survival status of the rats in the prevention group and treatment group was obviously better than that in the control group. As shown by the histological staining, the morphology, proliferation activity and bronchial state of lung tissues were better in the prevention group and treatment group than in the control group.
  
  
  CONCLUSIONS
  The hUC-MSCs have definite therapeutic effects on acute radiation pneumonitis in rats.
authors: Department of Spinal Cord Repairing, Jinan Military General Hospital, Jinan 250031, China.
authors: Rui
authors: R
authors: Wang
authors: Department of Neurology, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
authors: Chang-zheng
authors: CZ
authors: Zhu
authors: Department of Orthopedics, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
authors: Ping
authors: P
authors: Qiao
authors: Department of Orthopedics, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
authors: Jian
authors: J
authors: Liu
authors: Department of Orthopedics, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
authors: Qiang
authors: Q
authors: Zhao
authors: Department of Neurology, People's Hospital of Zhangqiu, Zhangqiu 250200, China.
authors: Kui-jie
authors: KJ
authors: Wang
authors: Department of Spinal Cord Repairing, Jinan Military General Hospital, Jinan 250031, China. Electronic address: woaifei371328@163.com.
authors: Ting-bao
authors: TB
authors: Zhao
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D017564:Radiation Pneumonitis / Q000473:pathology / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015703:Antigens, CD
keywords: Human umbilical cord mesenchymal stem cell; Radiation pneumonitis; Rat