title: Improvement of lipid profile by probiotic/protective cultures: study in a non-carcinogenic small intestinal cell model.
abstract: Plasma lipid levels are important risk factors for the development of atherosclerosis and coronary heart disease. Previous findings have shown that probiotic bacteria exert positive effects on hypercholesterolemia by lowering serum cholesterol and improving lipid profile that, in turn, leads to a reduced risk of coronary heart disease and atherosclerosis. Most of these studies were carried out with tumoral cell lines that have a metabolism quite different from that of normal cells and may thus respond differently to various stimuli. Here, we demonstrate the beneficial effects of some probiotics on cholesterol levels and pathways in normal small intestinal foetal epithelial tissue cells. The results show that Lactobacillus plantarum strain PCS 26 efficiently removes cholesterol from media, exhibits bile salt hydrolase activity, and up-regulates several genes involved in cholesterol metabolism. This study suggests that Lactobacillus plantarum PCS 26 might act as a liver X receptor agonist and help to improve lipid profiles in hypercholesterolemic patients or even dislipidemias in complex diseases such as the metabolic syndrome.
authors: Department of Biochemistry and Nutrition, Faculty of Medicine, University of Maribor, Slovenia.
authors: Mario
authors: M
authors: Gorenjak
authors: Lidija
authors: L
authors: Gradišnik
authors: Martin
authors: M
authors: Trapečar
authors: Mauro
authors: M
authors: Pistello
authors: Carina Pinto
authors: CP
authors: Kozmus
authors: Dejan
authors: D
authors: Škorjanc
authors: Pavel
authors: P
authors: Skok
authors: Tomaž
authors: T
authors: Langerholc
authors: Avrelija
authors: A
authors: Cencič
mesh_terms: D002784:Cholesterol / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D007421:Intestine, Small / Q000378:metabolism* / Q000382:microbiology*; D048191:Lactiplantibacillus plantarum / Q000254:growth & development / Q000378:metabolism*; D008954:Models, Biological; D019936:Probiotics / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D011506:Proteins; D002784:Cholesterol