title: [The over-expression of STAT1 and IFN-gamma in lesions of human oral lichen planus].
abstract: OBJECTIVE
  To understand the possible role of signal transducer and activator of transcription 1 (STAT1) and interferon-gamma (IFN-gamma) in the generation of local lesions of oral lichen planus (OLP).
  
  
  METHODS
  Formalin-fixed, paraffin-embedded tissues of 10 cases of normal oral epithelium and 48 cases of OLP were investigated for STAT1 and IFN-gamma proteins by using immunohistochemistry SABC method. The correlation between the expression of STAT1 and IFN-gamma proteins and the clinical and pathological characteristics in OLP were statistically analyzed.
  
  
  RESULTS
  (1) STAT1 and IFN-gamma were over expressed compared with healthy oral mucosa (P < 0.05). (2) The percentage of STAT1 over-expression in OLP with positive IFN-gamma staining was significantly higher than that in OLP with negative IFN-gamma staining (chi2 = 5.042, P < 0.05). A positive correlation between the over-expression of STAT1 and IFN-gamma was seen in OLP (r = 0.324, P < 0.05). (3) The percentage of over-expression of STAT1 in OLP with disease course less than 6 months was higher than that in OLP with disease course more than 6 months (chi2 = 5.077, P < 0.05), and a positive correlation was observed between the over-expression of IFN-gamma and the liquefaction of base cells in local lesions of OLP (r = -0.388, P < 0.05).
  
  
  CONCLUSIONS
  The over-expression of STAT1 and IFN-gamma may participate in the generation of local pathological damnification of OLP at the early stage.
authors: Deptment of Stomatology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China.
authors: Juan
authors: J
authors: He
authors: Deptment of Stomatology, the Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China.
authors: Yang
authors: Y
authors: Cai
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D007371:Interferon-gamma / Q000235:genetics / Q000378:metabolism*; D017676:Lichen Planus, Oral / Q000235:genetics / Q000378:metabolism*; D050794:STAT1 Transcription Factor / Q000235:genetics / Q000378:metabolism*
chemical_list: C573415:IFNG protein, human; D050794:STAT1 Transcription Factor; C494079:STAT1 protein, human; D007371:Interferon-gamma