title: Natural evolution of experimental vitreous hemorrhage and effects of corticosteroids on its course.
abstract: BACKGROUND
  The course and prognosis of vitreous hemorrhage (VH) are difficult to predict in spite of so far published experimental and clinical studies.
  
  
  OBJECTIVE
  The goal of this study was to follow the course and evaluate prognosis of vitreous hemorrhage.
  
  
  METHODS
  The experiment was performed on 19 Chinchilla rabbits (Oryctolagus cuniculus), both males and females (38 eyes), weighing 2500-3000 g, which were treated with autologous blood (B) from marginal ear vein--the first group, and the second group was treated with both blood and corticosteroids (B+CS). The course of vitreous hemorrhage was examined.
  
  
  RESULTS
  Our results have shown that the cellular reaction to vitreous hemorrhage is different, compared to hemorrhage in other types of tissue, which is due to absence of an early polymorphonuclear cellular reaction. Number of cells within vitreous body is very low.
  
  
  CONCLUSIONS
  Vitreous hemorrhage has unusual course followed by a small number of cells (mostly polymorphonuclear cells). This is most important fact why VH is cleared very slowly (about 6 to 9 weeks). CS has moderate influence on the acceleration ofVH absorption.
authors: School of Medicine, University of Belgrade, Belgrade, Serbia. draganv@beotel.net
authors: Dragan
authors: D
authors: Vuković
mesh_terms: D000305:Adrenal Cortex Hormones / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D005938:Glucocorticoids / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D011379:Prognosis; D011817:Rabbits; D014822:Vitreous Body / Q000187:drug effects* / Q000473:pathology; D014823:Vitreous Hemorrhage / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000305:Adrenal Cortex Hormones; D005938:Glucocorticoids