title: The regulation and functions of MAPK pathways in Drosophila.
abstract: The Mitogen-Activated Protein Kinase (MAPK) pathway represents one of the most conserved signaling cascades in multicellular organisms, since its cytoplasmic components can also be found in single-celled eukaryotic organisms such as yeast. With this broad view in mind, we can ask ourselves not only what are the seminal features and functions of the pathway in Drosophila, but also what have the studies in Drosophila taught us about the pathway in the wide range of organisms where it functions. We discuss the linearity of the MAPK signaling pathway in developmental decisions, and the ability of the developing organism to discriminate between different receptor tyrosine kinases that converge on the common MAPK pathway. Diverse modes of regulating the dynamics and level of MAPK signaling are presented. Finally, the convergence of MAPK signaling with other pathways is reviewed.
authors: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: benny.shilo@weizmann.ac.il.
authors: Ben-Zion
authors: BZ
authors: Shilo
mesh_terms: D000818:Animals; D001681:Biological Assay / Q000379:methods*; D004330:Drosophila / Q000235:genetics*; D066246:ErbB Receptors / Q000235:genetics / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000235:genetics; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics* / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics / Q000378:metabolism
chemical_list: D017468:Receptors, Fibroblast Growth Factor; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; D020928:Mitogen-Activated Protein Kinases
keywords: EGF receptor; ERK; FGF receptor; MAPK; Receptor tyrosine kinases