title: Association between a lumican promoter polymorphism and high myopia in the Chinese population: a meta-analysis of case-control studies.
abstract: OBJECTIVE
  To evaluate the relationship between lumican polymorphisms and high myopia in Chinese populations.
  
  
  METHODS
  An electronic search was conducted in Pubmed, Embase, Cochrane Library and the China Biological Medicine Database for articles published prior to September 30, 2012. A meta-analysis was performed to assess heterogeneity, combine results and determine publication bias.
  
  
  RESULTS
  This meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers (odds ratio: 0.531; 95% confidence interval, CI: 0.304-0.925; p = 0.025). There was some heterogeneity between studies. A metaregression showed that the mean axial length of controls weakens the effect of rs3759223 on high myopia (slope: -0.914; 95% CI: -1.490 to 0.337; p = 0.002). Sensitivity analysis confirmed the reliability and stability of this meta-analysis.
  
  
  CONCLUSIONS
  Chinese lumican rs3759223 C allele carriers may be at reduced risk of high myopia.
authors: School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical University, Wenzhou, PR China.
authors: Zhu-Jun
authors: ZJ
authors: Deng
authors: Ke-Qing
authors: KQ
authors: Shi
authors: Yi-Jiang
authors: YJ
authors: Song
authors: Yu-Xiao
authors: YX
authors: Fang
authors: Jianmin
authors: J
authors: Wu
authors: Guiling
authors: G
authors: Li
authors: Kai-Fu
authors: KF
authors: Tang
authors: Jia
authors: J
authors: Qu
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D011508:Chondroitin Sulfate Proteoglycans / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007632:Keratan Sulfate / Q000235:genetics*; D000071234:Lumican; D008297:Male; D047728:Myopia, Degenerative / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D055815:Young Adult
chemical_list: D011508:Chondroitin Sulfate Proteoglycans; C000604306:LUM protein, human; D000071234:Lumican; D007632:Keratan Sulfate