title: Validation of the Charlson Comorbidity Index in acutely hospitalized elderly adults: a prospective cohort study.
abstract: OBJECTIVE
  To determine whether the Charlson Comorbidity Index (CCI) predicts short- and long-term mortality.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  The medical department of two university hospitals and one community-based hospital.
  
  
  METHODS
  Acutely hospitalized individuals aged 65 and older with a mean age of 77.8 ± 7.9, 45.8% male (n = 1,313).
  
  
  METHODS
  In eligible persons, information on demographic characteristics, activities of daily living (modified Katz ADL Index score), and disease-related measures was collected within 48 hours after admission. Follow-up using self-reporting questionnaires was performed at 3 months and 1 year. Functional decline was defined as a decline of at least 1 point on the modified Katz ADL Index score at 12 months from baseline. Mortality data at 3 months and 1 and 5 years were collected from the municipal database.
  
  
  RESULTS
  Logistic regression analysis, adjusted for age and sex, showed that participants with a CCI of 5 or more had higher 3-month (odds ratio (OR) = 3.6, 95% confidence interval (CI) = 2.1-6.4), 1-year (OR = 7.1, 95% CI = 4.2-11.9), and 5-year (OR = 52.4, 95% CI = 13.3-206.4) mortality than those with a CCI of 0. Participants with CCI scores between 1 and 4 also had greater mortality risk at 3 months and 1 and 5 years.
  
  
  CONCLUSIONS
  The CCI independently predicts short- and long-term mortality in acutely ill hospitalized elderly adults.
authors: Geriatrics Section, Department of Internal Medicine, Academic Medical Center, Amsterdam, the Netherlands.
authors: Wijnanda J
authors: WJ
authors: Frenkel
authors: Erika J
authors: EJ
authors: Jongerius
authors: Miranda J
authors: MJ
authors: Mandjes-van Uitert
authors: Barbara C
authors: BC
authors: van Munster
authors: Sophia E
authors: SE
authors: de Rooij
mesh_terms: D000203:Activities of Daily Living; D000208:Acute Disease / Q000453:epidemiology; D000368:Aged; D015897:Comorbidity; D016001:Confidence Intervals; D004636:Emergency Service, Hospital / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D016017:Odds Ratio; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D015996:Survival Rate / Q000639:trends; D013997:Time Factors
keywords: Charlson Comorbidity Index; hospital; mortality risk