title: Late antibody-mediated rejection by de novo donor HLA-DP-specific antibody after renal transplantation: a case report.
abstract: The role of donor HLA-DP-specific antibodies after renal transplantation is controversial, and only preformed HLA-DP-specific antibodies have been shown to mediate rejection. Here we present a case of late humoral rejection mediated by de novo donor HLA-DP-specific antibodies in a non-sensitized recipient. This unique case demonstrates the pathogenic role of de novo anti-DP antibodies and suggests that HLA-DP matching might be relevant for renal transplantation.
authors: Division of Nephrology, University Hospital Zurich, Switzerland.
authors: Pietro E
authors: PE
authors: Cippà
authors: Institute of Surgical Pathology, University Hospital Zurich, Switzerland.
authors: Ariana
authors: A
authors: Gaspert
authors: Division of Nephrology, University Hospital Zurich, Switzerland.
authors: Christoph
authors: C
authors: Etter
authors: Interdisciplinary HLA Typing Laboratory, University Hospital Zurich, Switzerland.
authors: Zehra
authors: Z
authors: Guenduez
authors: Swiss National Reference Laboratory for Histocompatibility, Geneva University Hospital, Switzerland.
authors: Sylvie
authors: S
authors: Ferrari-Lacraz
authors: Interdisciplinary HLA Typing Laboratory, University Hospital Zurich, Switzerland.
authors: Barbara
authors: B
authors: Rüsi
authors: Division of Nephrology, University Hospital Zurich, Switzerland. Electronic address: thomas.fehr@usz.ch.
authors: Thomas
authors: T
authors: Fehr
mesh_terms: D000906:Antibodies / Q000097:blood / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D001706:Biopsy; D006084:Graft Rejection / Q000276:immunology*; D006682:HLA-DP Antigens / Q000276:immunology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
chemical_list: D000906:Antibodies; D006682:HLA-DP Antigens