title: Lactobacillus Paracasei subsp. Paracasei F19; a farmacogenomic and clinical update.
abstract: BACKGROUND
  Many reports in literature have underlined particular features of Lactobacillus paracasei subsp paracasei F19, however a critical review of main clinical outcomes has not been performed so far.
  
  
  OBJECTIVE
  This review summarizes the most relevant reports, in terms of clinical benefits, of Lactobacillus paracasei subsp paracasei F19 administration reviewing it’s historical background and outlining new interesting perspectives in clinical practice.
  
  
  METHODS
  We searched Pubmed/Medline using the terms “ Lactobacillus paracasei subsp paracasei F19”. All clinical and experimental articles on the use of Lactobacillus paracasei subsp paracasei F19 were included.
  
  
  CONCLUSIONS
  The genetic stability of F19, the most relevant clinical claim, renders it’s administration reliable and effective in immunocompromised people. Adequate concentrations of this strain support a dose/effect strategy ranging between NF B host macrophage activation to pathogenic bacteria overgrowth control as well as to fine interaction with the gut nerve endings. Moreover preliminary results from our lab support the formulation of F19 encapsulated with lyophilized HA in patients with IBD due to both an increased mucous-strain adherence and a possible enhanced strain proliferation and maintenance.
  
  
  CONCLUSIONS
  Further experiments are required to overcome the lack of informations about this new formulation for IBD management.
authors: Department of Clinical Microbiology. University of Modena e Reggio Emilia. Modena. Italy.. alessandro811@hotmail.it.
authors: Alessandro
authors: A
authors: Di Cerbo
authors: Department of General Surgery and Surgical Specialties. University of Modena e Reggio Emilia. Modena. Italy..
authors: Beniamino
authors: B
authors: Palmieri
mesh_terms: D006801:Humans; D007778:Lactobacillus / Q000235:genetics / Q000378:metabolism*; D008297:Male; D019936:Probiotics / Q000008:administration & dosage*