title: Impact of Scedosporium apiospermum complex seroprevalence in patients with cystic fibrosis.
abstract: BACKGROUND
  Species of the Scedosporium apiospermum complex (S. a complex) are emerging fungi responsible for chronic airway colonization in cystic fibrosis (CF) patients. Recent studies performed on Aspergillus fumigatus suggest that the colonization of the airways by filamentous fungi may contribute to the progressive deterioration of lung function.
  
  
  METHODS
  We studied S. a complex seroprevalence, as a marker of close contact between patient and the fungi, in a large monocentric cohort of CF patients attended in a reference centre in Lyon, France.
  
  
  RESULTS
  Serum samples from 373 CF patients were analysed. Antibodies against S. a complex were detected in 35 patients (9.4%). In multivariate analysis, S. a complex seropositivity was only associated with seropositivity to A. fumigatus.
  
  
  CONCLUSIONS
  This study does not suggest an association between sensitization against S. a complex and poorer lung function in CF. Prospective studies are needed to evaluate the impact of both seropositivity and S. a complex colonization on the course of CF.
authors: Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Adult Cystic Fibrosis Reference Center, 69495 Pierre-Bénite, France; Université de Lyon, Lyon, France. Electronic address: perrine.parize@nck.aphp.fr.
authors: Perrine
authors: P
authors: Parize
authors: L'UNAM Université, Université d'Angers, Groupe d'Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, Institut de Biologie en Santé-IRIS, 49933 Angers, France.
authors: Sandrine
authors: S
authors: Billaud
authors: Hospices Civils de Lyon, Service de Parasitologie et de Mycologie Médicale, 69317 Lyon, France; University Lyon 1, Malaria Research Unit, ICBMS, CNRS UMR, 69373 Lyon, France.
authors: Anne L
authors: AL
authors: Bienvenu
authors: Hospices Civils de Lyon, Pôle IMER, Université de Lyon, 69424 Lyon, France.
authors: Stéphanie
authors: S
authors: Bourdy
authors: Hospices Civils de Lyon, Pôle IMER, Université de Lyon, 69424 Lyon, France.
authors: Marie A
authors: MA
authors: le Pogam
authors: Université de Lyon, Lyon, France; Hospices Civils de Lyon, Hôpital Femme-Mère-Enfant, Pediatric Cystic Fibrosis Reference Center, 69500 Bron, France.
authors: Philippe
authors: P
authors: Reix
authors: Hospices Civils de Lyon, Service de Parasitologie et de Mycologie Médicale, 69317 Lyon, France; University Lyon 1, Malaria Research Unit, ICBMS, CNRS UMR, 69373 Lyon, France.
authors: Stéphane
authors: S
authors: Picot
authors: L'UNAM Université, Université d'Angers, Groupe d'Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, Institut de Biologie en Santé-IRIS, 49933 Angers, France.
authors: Raymond
authors: R
authors: Robert
authors: Université Paris-Descartes, Hôpital Necker-Enfants malades, Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, IHU Imagine, 75015 Paris, France.
authors: Olivier
authors: O
authors: Lortholary
authors: L'UNAM Université, Université d'Angers, Groupe d'Etude des Interactions Hôte-Pathogène, UPRES-EA 3142, Institut de Biologie en Santé-IRIS, 49933 Angers, France; Laboratoire de Parasitologie-Mycologie, Institut de Biologie en Santé-PBH, Centre Hospitalier Universitaire, 49933 Angers, France.
authors: Jean-Philippe
authors: JP
authors: Bouchara
authors: Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Adult Cystic Fibrosis Reference Center, 69495 Pierre-Bénite, France.
authors: Isabelle
authors: I
authors: Durieu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D005260:Female; D005541:Forced Expiratory Volume; D005602:France; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D021681:Scedosporium; D016036:Seroepidemiologic Studies; D055815:Young Adult
keywords: Cystic fibrosis/microbiology; Respiratory function tests; Scedosporium apiospermum; Serologic tests