title: Lipoprotein-associated phospholipase A2 during the hyperacute stage of ischemic and hemorrhagic strokes.
abstract: BACKGROUND
  The objectives of the study were to compare lipoprotein-associated phospholipase A2 (Lp-PLA2) levels in a prospective cohort including both ischemic and hemorrhagic strokes at the hyperacute phase, and to investigate if these levels were associated with stroke severity.
  
  
  METHODS
  Lp-PLA2 mass and activity were measured during the first 6 hours of symptom onset before any therapeutic intervention. The Lp-PLA2 level was analyzed by comparing the mass and activities in ischemic strokes and spontaneous intracerebral hemorrhages (ICH). Correlations between Lp-PLA2 levels and clinical scores as well as stroke volumes were made. The temporal evolution of Lp-PLA2 during the first week was analyzed in ischemic stroke patients.
  
  
  RESULTS
  Lp-PLA2 mass was higher in ICH than in ischemic stroke (P = .001). Lp-PLA2 activity at admission correlated with initial and follow-up stroke volume in ICH (P = .003 and P = .004, respectively) but not in ischemic stroke. None of the measurements correlated with clinical severity for either diagnosis. Lp-PLA2 mass decreased during the first week after the use of statins in ischemic stroke, whereas the activity remained stable.
  
  
  CONCLUSIONS
  Lp-PLA2 mass is higher in ICH compared with ischemic stroke during the hyperacute stage. Lp-PLA2 activity is associated with stroke volume in ICH but not in ischemic stroke. This suggests that Lp-PLA2 mass and activity could provide different information in the hyperacute stage of stroke.
authors: CRICM-Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UPMC Paris 6, Inserm, U975, CNRS, UMR, Paris, France; COGIMAGE, UPMC Paris 6, Paris, France; APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Paris, France. Electronic address: charlotte.rosso@psl.aphp.fr.
authors: Charlotte
authors: C
authors: Rosso
authors: Unité de prévention des maladies cardiovasculaires, Hôpital Pitié-Salpêtrière, Paris, France; Laboratoire d'imagerie fonctionnelle, INSERM U678, UPMC Paris 6, Paris, France.
authors: David
authors: D
authors: Rosenbaum
authors: APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Paris, France.
authors: Christine
authors: C
authors: Pires
authors: APHP, Service de Biochimie Métabolique, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix, Paris, France.
authors: Corinne
authors: C
authors: Cherfils
authors: APHP, Service de Biochimie Métabolique, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix, Paris, France.
authors: Nabil
authors: N
authors: Koujah
authors: APHP, Service de Biochimie Métabolique, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix, Paris, France.
authors: Fouzi
authors: F
authors: Mestari
authors: APHP, Service de Biochimie Métabolique, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix, Paris, France.
authors: Emeline
authors: E
authors: Gillet
authors: APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Paris, France.
authors: Sophie
authors: S
authors: Crozier
authors: APHP, Service de Neuroradiologie, Hôpital Pitié-Salpêtrière, Paris, France.
authors: Mélika
authors: M
authors: Sahli-Amor
authors: CRICM-Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, UPMC Paris 6, Inserm, U975, CNRS, UMR, Paris, France; COGIMAGE, UPMC Paris 6, Paris, France; APHP, Urgences Cérébro-Vasculaires, Hôpital Pitié-Salpêtrière, Paris, France.
authors: Yves
authors: Y
authors: Samson
authors: APHP, Service de Biochimie Métabolique, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix, Paris, France; EA 4466, Département de Biologie Expérimentale, Métabolique et Clinique, Faculté de Pharmacie, Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
authors: Dominique
authors: D
authors: Bonnefont-Rousselot
authors: APHP, Service de Biochimie Métabolique, Hôpitaux Universitaires Pitié-Salpêtrière-Charles Foix, Paris, France; UPMC Université Paris 06, Paris, France.
authors: Randa
authors: R
authors: Khani-Bittar
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000032:analysis / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis; D002545:Brain Ischemia / Q000201:enzymology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000201:enzymology*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D020521:Stroke / Q000201:enzymology*
chemical_list: D015415:Biomarkers; D008055:Lipids; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase
keywords: Lipids and lipoprotein; cerebral hemorrhage; cerebral infarction; statins; stroke