title: Effectiveness of combined use of imprint cytological and histological examination in CT-guided tissue-core biopsy.
abstract: OBJECTIVE
  This study evaluated the efficacy of the combination of imprint cytology and histology in tissue-core percutaneous biopsy under real-time computed tomography (CT) fluoroscopic guidance.
  
  
  METHODS
  Between October 2009 and June 2013, 156 percutaneous needle biopsies were performed in our institution. Those obtained by tissue-core biopsy underwent both imprint cytological and histological examinations routinely after touch imprint cytology was performed on site to evaluate the samples' sufficiency for cytological and pathological examination. Final diagnosis was confirmed by independent surgical pathology, independent culture results or clinical follow-up.
  
  
  RESULTS
  Rates of adequate specimens and precise diagnosis, by combined cytological and histological examination were 100 % (156/156) and 96.2 % (150/156), by cytology 94.4 % (152/156) and 83.3 % (130/156) and by histology 99.3 % (155/156) and 92.3 % (144/156). Precise diagnosis was achieved by combined examinations in 94.7 % (89/94) of thoracic lesions, 97.6 % (40/41) of musculoskeletal lesions, and 100 % (21/21) of abdominal, pelvic and retroperitoneal lesions. In all 104 lesions diagnosed as malignant by CT-guided biopsy and in 30 of 52 diagnosed as benign, specific cell types could be proved by combined examinations.
  
  
  CONCLUSIONS
  Combined imprint cytology and histology performed after on-site touch imprint cytological evaluation improved the diagnostic ability of CT fluoroscopically guided biopsy.
  
  
  CONCLUSIONS
  • CT-guided needle biopsy is a well-established diagnostic technique. • Touch imprint cytological evaluation on site is helpful in improving quality of CT-guided biopsy. • The rate of diagnosing malignant lymphoma specifically with cytological examination is relatively low. • The rate of specific diagnosis of benign lesion in musculoskeletal regions is low.
authors: Department of Diagnostic Radiology, Institute and Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, 734-8551, Japan, yamagami@hiroshima-u.ac.jp.
authors: Takuji
authors: T
authors: Yamagami
authors: Rika
authors: R
authors: Yoshimatsu
authors: Kenji
authors: K
authors: Kajiwara
authors: Masaki
authors: M
authors: Ishikawa
authors: Tomohiro
authors: T
authors: Matsumoto
authors: Hideaki
authors: H
authors: Kakizawa
authors: Naoyuki
authors: N
authors: Toyoda
authors: Terumitsu
authors: T
authors: Hasebe
authors: Kazuo
authors: K
authors: Awai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods / Q000592:standards; D002648:Child; D005260:Female; D005471:Fluoroscopy; D006801:Humans; D061705:Image-Guided Biopsy / Q000379:methods / Q000592:standards; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult