title: Colon preneoplastic lesions in animal models.
abstract: The animal model is a powerful and fundamental tool in the field of biochemical research including toxicology, carcinogenesis, cancer therapeutics and prevention. In the carcinogenesis animal model system, numerous examples of preneoplastic lesions have been isolated and investigated from various perspectives. This may indicate that several options of endpoints to evaluate carcinogenesis effect or therapeutic outcome are presently available; however, classification of preneoplastic lesions has become complicated. For instance, these lesions include aberrant crypt foci (ACF), dysplastic ACF, flat ACF, β-catenin accumulated crypts, and mucin-depleted foci. These lesions have been induced by commonly used chemical carcinogens such as azoxymethane (AOM), 1,2-dimethylhydrazine (DMH), methylnitrosourea (MUN), or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Investigators can choose any procedures or methods to examine colonic preneoplastic lesions according to their interests and the objectives of their experiments. Based on topographical, histopathological, and biological features of colon cancer preneoplastic lesions in the animal model, we summarize and discuss the character and implications of these lesions.
authors: Department of Molecular Toxicology, Graduate School of Medical Sciences and Medical School, Nagoya City University,1 Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan.
authors: Masumi
authors: M
authors: Suzui
authors: Radiation Effect Accumulation and Prevention Project, Fukushima Project Headquarters and Radiobiology for Children's Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors: Takamitsu
authors: T
authors: Morioka
authors: Department of Pathology and Oncology, Graduate School of Medicine and Faculty of Medicine, University of the Ryukyus Faculty of Medicine, 207 Uehara, Nishihara-cho, Okinawa 903-0215, Japan.
authors: Naoki
authors: N
authors: Yoshimi
keywords: animal model; colon carcinogenesis; preneoplastic lesion; topographic view