title: Tumor marker score for prognostication of early-stage squamous cell cervical cancer.
abstract: OBJECTIVE
  Histopathological and clinical scores to predict prognosis in cervical cancer have been of limited value. In the present study a tumor marker expression score was evaluated for prognostication in early-stage cervical cancer.
  
  
  METHODS
  The entire study population included 128 women with invasive squamous cell cervical cancer followed-up for at least 10 years.
  
  
  RESULTS
  Expression of 12 tumor markers (epidermal growth factor receptor (EGFR), Ki-67, c-MYC, p53, p27, E-cadherin, CD44, vascular endothelial growth factor receptor (VEGF), cyclooxygenase-2 (COX2), CD4, and leucine-rich immunoglobulin-like repeats-1 (LRIG1) and LRIG2, considered relevant for cervical cancer prognostication was evaluated by immunohistochemistry. Expression of five markers, LRIG1, LRIG2, p53, COX2 and c-MYC were useful to make a prognostication score, ranging from 0 to 5. Score 0-1 correlated to less than 5% 10-year mortality, while the mortality rate of those with score 4-5 approached 70%; those with score 2 formed an intermediate group. Using different models, a high sensitivity, specificity, positive predictive value and negative predictive value was attained.
  
  
  CONCLUSIONS
  Tumor marker scoring could be an adjunct to histopathological and clinical parameters in prognostication of early-stage cervical cancer.
authors: Center for Clinical Research, Nissers vag 3, 79182 Falun, Sweden. dan.hellberg@ltdalarna.se and Associate Professor Tibor Tot, Department of Pathology and Clinical Cytology, Falun Hospital, 79182 Falun, Sweden. E-mail: tibor.tot@ltdalarna.se.
authors: Dan
authors: D
authors: Hellberg
authors: Tibor
authors: T
authors: Tot
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: Cervical cancer; prognosis; tumor markers