title: Low hip bone mineral density predicts mortality in maintenance hemodialysis patients: a five-year follow-up study.
abstract: BACKGROUND
  Bone loss is common among hemodialysis patients and contributes to mortality. The association between bone loss and vascular calcification may explain the increased mortality risk. Studies on the association between decreased bone mass and mortality in maintenance hemodialysis patients are limited.
  
  
  METHODS
  Eighty-three hemodialysis patients underwent bone mineral density (BMD) and coronary artery calcification (CAC) measurements. The relationship between BMD and mortality was analyzed after a 5-year follow-up period.
  
  
  RESULTS
  Eighty percent of the patients had reduced hip BMD. In univariate Cox regression analyses, age, cardiovascular disease, dyslipidemia, increased CAC score, increased comorbidity score and decreased hip BMD were associated with mortality. Low hip BMD remained independently associated with mortality after adjustments for cardiovascular risk factors, comorbidity score and CAC score. Patients with BMD in the lowest tertile had the worst survival.
  
  
  CONCLUSIONS
  Low hip BMD predicted mortality in maintenance hemodialysis patients independent of CAC.
authors: Division of Nephrology, Department of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors: Sinee
authors: S
authors: Disthabanchong
authors: Sutipong
authors: S
authors: Jongjirasiri
authors: Surawat
authors: S
authors: Adirekkiat
authors: Vasant
authors: V
authors: Sumethkul
authors: Atiporn
authors: A
authors: Ingsathit
authors: Somnuek
authors: S
authors: Domrongkitchaiporn
authors: Bunyong
authors: B
authors: Phakdeekitcharoen
authors: Surasak
authors: S
authors: Kantachuvesiri
authors: Chagriya
authors: C
authors: Kitiyakara
mesh_terms: D000368:Aged; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000150:complications* / Q000503:physiopathology; D002114:Calcinosis / Q000150:complications / Q000473:pathology; D003324:Coronary Artery Disease / Q000150:complications / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006615:Hip / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000401:mortality*; D012307:Risk Factors; D016896:Treatment Outcome