title: Nanoparticles for multimodal in vivo imaging in nanomedicine.
abstract: While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.
authors: Weldon School of Biomedical Engineering, West Lafayette, IN, USA ; Birck Nanotechnology Center, West Lafayette, IN, USA ; Bindley Bioscience Center, West Lafayette, IN, USA.
authors: Jaehong
authors: J
authors: Key
authors: Weldon School of Biomedical Engineering, West Lafayette, IN, USA ; Birck Nanotechnology Center, West Lafayette, IN, USA ; Bindley Bioscience Center, West Lafayette, IN, USA ; College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
authors: James F
authors: JF
authors: Leary
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D064847:Multimodal Imaging / Q000379:methods*; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D025321:Surgery, Computer-Assisted / Q000379:methods*
chemical_list: D003287:Contrast Media
keywords: CT; MRI; NIRF; PET; cancer; multimodal imaging; nanomedicine; nanoparticles