title: Award winner for outstanding research in the PhD category, 2014 Society for Biomaterials annual meeting and exposition, Denver, Colorado, April 16-19, 2014: Decellularized adipose matrix hydrogels stimulate in vivo neovascularization and adipose formation.
abstract: Decellularization of tissues offers the ability to produce tissue-specific extracellular matrix (ECM) scaffolds that recreate many of the biochemical aspects of the tissue of interest. In this study, we describe the in vivo function of decellularized adipose ECM hydrogels for treating subcutaneous adipose deficits. Adipose ECM hydrogels were combined with either adipose-derived adult stem cells or a biocompatible cross-linker, injected subcutaneously into nude mice, and evaluated over the course of 1 month. These ECM hydrogels showed improved integration with the surrounding tissue in vivo compared to a clinical standard soft tissue filler, Juvederm, and stimulated neovascularization. More importantly, these adipose ECM hydrogels facilitated new adipose regeneration within the material at 1 month, a feature not seen with current clinical soft tissue fillers. These results contribute to the growing evidence that ECM-based materials are capable of stimulating subcutaneous adipose regeneration, suggesting that future soft tissue filler materials could incorporate ECM elements in order to restore function to adipose deficits instead of simply filling them with static materials.
authors: Department of Bioengineering & Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, California.
authors: D
authors: D
authors: Adam Young
authors: Vaibhav
authors: V
authors: Bajaj
authors: Karen L
authors: KL
authors: Christman
mesh_terms: D050156:Adipogenesis; D000273:Adipose Tissue / Q000098:blood supply / Q000737:chemistry* / Q000502:physiology*; D000328:Adult; D053687:Adult Stem Cells / Q000166:cytology; D000818:Animals; D001363:Awards and Prizes; D001672:Biocompatible Materials / Q000008:administration & dosage / Q000737:chemistry*; D002478:Cells, Cultured; D003120:Colorado; D005109:Extracellular Matrix / Q000737:chemistry*; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000008:administration & dosage / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D018919:Neovascularization, Physiologic; D012038:Regeneration; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels
keywords: adipose; decellularization; hydrogel; regeneration; stem cell