title: [Association of diabetes type 2 and depression - behavioural and biological aspects].
abstract: OBJECTIVE
  Type 2 diabetes and depression often appear together. Although health behaviour and risk factors partially explain this association, other potential mechanisms have yet to be elucidated.
  
  
  METHODS
  Explorative literature research for reviews on the topic in PubMed. Additional key-word guided research for studies in PubMed and Cochrane Library employing the keywords "diabetes" AND "depression" in combination with identified relevant single aspects (MeSH-terms) for certain neuroendocrine alterations, neuropathological und neurobiochemestric changes as well as the role of antidepressants.
  
  
  RESULTS
  There are no satisfying explanatory models for the complex interaction of both diseases concerning behavioural factors and pathophysiological changes. Currently there are only many single aspects of shared or interacting pathophysiology or behaviour conspicuity.
  
  
  CONCLUSIONS
  The objective of this review is to summarize these aspects and their contributions to the interacting pathophysiology of the two diseases.
authors: Institut für Allgemeinmedizin, Heinrich-Heine-Universität, Universitätsklinikum Düsseldorf.
authors: G
authors: G
authors: Wagner
authors: Funktionsbereich Public Health, Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf.
authors: A
authors: A
authors: Icks
authors: Institut für Allgemeinmedizin, Heinrich-Heine-Universität, Universitätsklinikum Düsseldorf.
authors: M
authors: M
authors: Redaelli
authors: Institut für Biometrie und Epidemiologie, Deutsches Diabetes-Zentrum, Leibniz-Zentrum für Diabetesforschung an der Heinrich-Heine-Universität Düsseldorf.
authors: B
authors: B
authors: Albers
authors: Institut für Allgemeinmedizin, Heinrich-Heine-Universität, Universitätsklinikum Düsseldorf.
authors: H-H
authors: HH
authors: Abholz
mesh_terms: D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D015897:Comorbidity; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood; D003866:Depressive Disorder / Q000453:epidemiology* / Q000503:physiopathology* / Q000523:psychology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology* / Q000503:physiopathology* / Q000523:psychology; D015438:Health Behavior; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D050417:Insulin-Secreting Cells / Q000502:physiology; D008019:Life Style; D018384:Oxidative Stress / Q000502:physiology; D012307:Risk Factors; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D000928:Antidepressive Agents; D016207:Cytokines