title: Effects of oral intake of cetirizine HCl and desloratadine molecules on the middle ear mucosa: an experimental animal study.
abstract: We have planned to demonstrate histopathologic effects of mid- or long-term oral use of desloratadine and cetirizine HCl molecules on middle ear mucosa of rats. Thirty-six rats were randomized equally into six groups. Desloratadine groups received once daily doses of 1 mg/ml desloratadine for 30 (D30 Group) or 60 (D60 Group) days. The Cetirizine study groups were given once daily doses of 1 mg/ml cetirizine for 30 (S30 Group) or 60 (S60 Group) days. Control groups were given 2 cc physiologic saline using orogastric gavage method through a 12 G gavage catheter for 30 (K30 Group) or 60 (K60) days. At the end of 30 days, D30, S30 and K30 Groups were sacrificed. Tissue samples harvested from groups were evaluated between 1 and 4 Grades for histological characteristics of middle ear canal, eardrum, middle ear epithelium and connective tissue, edema, vascular congestion and inflammatory cells. In the control group no pathological finding was encountered in rats sacrificed on 30 and 60 days. No statistical difference was observed when groups were compared on external ear epithelial tissue, external ear sebaceous gland, middle ear inflammation, and middle ear capillary dilatation both on 30 and 60 days. Tympanic membrane collagen was more evident in D30 and D60 groups when compared with C30 and C60 groups. Comparison of histopathological grading results between 30 and 60 days revealed no significant changes. In conclusion, oral intake of cetirizine and desloratadine preparations has effects of tympanic membrane collagen, degrees of edema and vascular congestion being more prominent with desloratadine molecule.
authors: Department of Otorhinolaryngology, Atatürk Training and Research Hospital, Izmir Katip Celebi University, Izmir, Turkey, songumurat@yahoo.com.
authors: Murat
authors: M
authors: Songu
authors: Yilmaz
authors: Y
authors: Ozkul
authors: Seyithan
authors: S
authors: Kirtay
authors: Secil
authors: S
authors: Arslanoglu
authors: Mahmut
authors: M
authors: Ozkut
authors: Sevinc
authors: S
authors: Inan
authors: Kazim
authors: K
authors: Onal
mesh_terms: D000284:Administration, Oral; D000818:Animals; D017332:Cetirizine / Q000494:pharmacology*; D004432:Ear, Middle / Q000187:drug effects* / Q000473:pathology; D004487:Edema / Q000473:pathology; D039563:Histamine H1 Antagonists, Non-Sedating / Q000494:pharmacology*; D006940:Hyperemia / Q000473:pathology; D017336:Loratadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009092:Mucous Membrane / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014432:Tympanic Membrane / Q000187:drug effects* / Q000473:pathology
chemical_list: D039563:Histamine H1 Antagonists, Non-Sedating; D017336:Loratadine; C121345:desloratadine; D017332:Cetirizine