title: Dietary exposure to perfluoroalkyl acids of specific French adult sub-populations: high seafood consumers, high freshwater fish consumers and pregnant women.
abstract: Perfluoroalkyl acids (PFAAs) are globally found in various media, including food and especially fishery products. In the present study, the dietary exposure to 15 perfluoroalkyl acids was assessed for 3 French adult populations, namely high seafood consumers, high freshwater fish consumers, and pregnant women. Purified food extracts were analysed by LC-MS/MS and PFBA, PFPA, PFHxA, PFHpA, PFOA, PFNA, PFDA, PFUnA, PFTrDA, PFTeDA, PFBS, PFHxS, PFHpS, PFOS and PFDS were monitored and quantified according to the isotope dilution principle. Under lower bound (LB) hypothesis (i.e. contamination values<LOD considered as 0), high freshwater fish consumers appear as the most exposed to PFOS (7.5 ng.kg(-1) bw.d(-1)), PFUnA (1.3 ng.kg(-1) bw.d(-1)), PFDA (0.4 ng.kg(-1) bw.d(-1)) and PFHpS (0.03 ng.kg(-1) bw.d(-1)) while high seafood consumers appear as the most exposed to PFOA (1.2 ng.kg(-1) bw.d(-1)), PFNA (0.2 ng.kg(-1) bw.d(-1)) and PFHxS (0.06 ng.kg(-1) bw.d(-1)). For all considered populations, the major exposure contributors are fish, seafood and water under LB hypothesis, while dairy products, bread and crispbread are the main contributors under upper bound (UB) hypothesis. Besides this food exposure assessment, further studies are needed to assess the more global PFAA exposure, taking into account indoor and outdoor air, dust and cutaneous contact, which could be other important contributors for this particular class of chemicals.
authors: Risk Assessment Directorate, French Agency for Food, Environmental and Occupational Health and Safety (ANSES), 27-31 avenue du Général Leclerc, Maisons-Alfort 94701, France. Electronic address: ami.s.yamada@gmail.com.
authors: A
authors: A
authors: Yamada
authors: Risk Assessment Directorate, French Agency for Food, Environmental and Occupational Health and Safety (ANSES), 27-31 avenue du Général Leclerc, Maisons-Alfort 94701, France. Electronic address: nawel.bemrah@anses.fr.
authors: N
authors: N
authors: Bemrah
authors: LUNAM Université, Oniris, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Nantes 44307, France. Electronic address: bruno.veyrand@oniris-nantes.fr.
authors: B
authors: B
authors: Veyrand
authors: LUNAM Université, Oniris, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Nantes 44307, France. Electronic address: charles.pollono@oniris-nantes.fr.
authors: C
authors: C
authors: Pollono
authors: Risk Assessment Directorate, French Agency for Food, Environmental and Occupational Health and Safety (ANSES), 27-31 avenue du Général Leclerc, Maisons-Alfort 94701, France. Electronic address: mathilde.merlo@anses.fr.
authors: M
authors: M
authors: Merlo
authors: Risk Assessment Directorate, French Agency for Food, Environmental and Occupational Health and Safety (ANSES), 27-31 avenue du Général Leclerc, Maisons-Alfort 94701, France. Electronic address: virginie.desvignes@anses.fr.
authors: V
authors: V
authors: Desvignes
authors: Risk Assessment Directorate, French Agency for Food, Environmental and Occupational Health and Safety (ANSES), 27-31 avenue du Général Leclerc, Maisons-Alfort 94701, France. Electronic address: sirotv@gmail.com.
authors: V
authors: V
authors: Sirot
authors: LUNAM Université, Oniris, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Nantes 44307, France. Electronic address: philippe.marchand@oniris-nantes.fr.
authors: P
authors: P
authors: Marchand
authors: Service de Gynécologie-Obstétrique, Hôpital Paule de Viguier, CHU de Toulouse, Hôtel-Dieu, 2 rue Viguerie, Toulouse cedex 9 31052, France. Electronic address: berrebi.a@chu-toulouse.fr.
authors: A
authors: A
authors: Berrebi
authors: LUNAM Université, Oniris, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Nantes 44307, France. Electronic address: ronan.cariou@oniris-nantes.fr.
authors: R
authors: R
authors: Cariou
authors: LUNAM Université, Oniris, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Nantes 44307, France. Electronic address: jean-philippe.antignac@oniris-nantes.fr.
authors: J P
authors: JP
authors: Antignac
authors: LUNAM Université, Oniris, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Nantes 44307, France. Electronic address: bruno.lebizec@oniris-nantes.fr.
authors: B
authors: B
authors: Le Bizec
authors: Risk Assessment Directorate, French Agency for Food, Environmental and Occupational Health and Safety (ANSES), 27-31 avenue du Général Leclerc, Maisons-Alfort 94701, France. Electronic address: leblanc.jch@gmail.com.
authors: J C
authors: JC
authors: Leblanc
mesh_terms: D000328:Adult; D000818:Animals; D004032:Diet / Q000706:statistics & numerical data*; D004781:Environmental Exposure / Q000706:statistics & numerical data*; D005260:Female; D005466:Fluorocarbons / Q000032:analysis*; D005506:Food Contamination / Q000706:statistics & numerical data; D005602:France; D006801:Humans; D008297:Male; D018811:Maternal Exposure / Q000706:statistics & numerical data; D011247:Pregnancy; D017747:Seafood / Q000706:statistics & numerical data*; D014874:Water Pollutants, Chemical / Q000032:analysis*
chemical_list: D005466:Fluorocarbons; D014874:Water Pollutants, Chemical
keywords: Dietary exposure; Fish consumer; Perfluoroalkyl acid; Pregnant woman