title: Turning reactive glia into functional neurons in the brain.
abstract: Following brain injury, reactive glial cells can create scars that inhibit neural repair responses. In this issue of Cell Stem Cell, Guo et al. report that overexpression of NeuroD1 in vivo can directly reprogram reactive glial cells into glutamatergic and GABAergic neurons that integrate into the host's neural circuitry.
authors: Department of Neuroscience and Department of Neurology, School of Medicine and Public Health, Waisman Center, University of Wisconsin, Madison, WI 53705, USA.
authors: Jianfeng
authors: J
authors: Lu
authors: Department of Neuroscience and Department of Neurology, School of Medicine and Public Health, Waisman Center, University of Wisconsin, Madison, WI 53705, USA.
authors: Robert A
authors: RA
authors: Bradley
authors: Department of Neuroscience and Department of Neurology, School of Medicine and Public Health, Waisman Center, University of Wisconsin, Madison, WI 53705, USA. Electronic address: zhang@waisman.wisc.edu.
authors: Su-Chun
authors: SC
authors: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000473:pathology*; D000818:Animals; D001930:Brain Injuries / Q000473:pathology*; D065150:Cellular Reprogramming; D006801:Humans; D009457:Neuroglia / Q000166:cytology*; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*