title: Prognostic value of late gadolinium enhancement on cardiac magnetic resonance imaging in Japanese hypertrophic cardiomyopathy patients.
abstract: BACKGROUND
  The prognostic value of late gadolinium enhancement (LGE) on contrast-enhanced cardiovascular magnetic resonance (CMR) in Japanese hypertrophic cardiomyopathy (HCM) patients in a large, single-center cohort was investigated.
  
  
  RESULTS
  A total of 345 HCM patients (mean age, 59±17 years; 214 male) underwent CMR with gadolinium enhancement, and were followed (mean duration, 21.8 months) for cardiovascular events. Patients were divided into event-positive and event-negative groups. The clinical and CMR characteristics were compared between the 2 groups, and predictors of cardiovascular events assessed on multivariate analysis. LGE was positive in 252 patients (73%). The annual cardiovascular events rate was significantly higher in patients with LGE than in those without (6.2%/year vs. 0.6%/year, P=0.003). On multivariate analysis, LGE (hazard ratio [HR], 7.436; 95% confidence interval [CI]: 1.001-55.228, P=0.050), increased myocardial mass index (HR, 1.013; 95% CI: 1.002-1.023, P=0.018), reduced left ventricular ejection fraction (HR, 0.965; 95% CI: 0.945-0.985, P=0.001), and atrial fibrillation (HR, 2.257; 95% CI: 1.024-4.976, P=0.043) were significantly associated with cardiovascular events.
  
  
  CONCLUSIONS
  The presence of LGE, increased myocardial mass index, reduced left ventricular ejection fraction and atrial fibrillation were independent predictors of adverse prognosis in Japanese HCM patients.
authors: Department of Cardiology, Sakakibara Heart Institute.
authors: Yasuki
authors: Y
authors: Hen
authors: Nobuo
authors: N
authors: Iguchi
authors: Yuko
authors: Y
authors: Utanohara
authors: Kaori
authors: K
authors: Takada
authors: Haruhiko
authors: H
authors: Machida
authors: Morimasa
authors: M
authors: Takayama
authors: Tetsuya
authors: T
authors: Sumiyoshi
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000503:physiopathology; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D003287:Contrast Media / Q000008:administration & dosage*; D005500:Follow-Up Studies; D005682:Gadolinium / Q000008:administration & dosage*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D013318:Stroke Volume
chemical_list: D003287:Contrast Media; D005682:Gadolinium