title: SMAL: A Resource of Spontaneous Mutation Accumulation Lines.
abstract: Mutation is the ultimate source of genetic variation and evolution. Mutation accumulation (MA) experiments are an alternative approach to study de novo mutation events directly. We have constructed a resource of Spontaneous Mutation Accumulation Lines (SMAL; http://cefg.uestc.edu.cn/smal), which contains all the current publicly available MA lines identified by high-throughput sequencing. We have relocated and mapped the mutations based on the most recent genome annotations. A total of 5,608 single base mutations and 540 other mutations were obtained and are recorded in the current version of the SMAL database. The integrated data in SMAL provide detailed information that can be used in new theoretical analyses. We believe that the SMAL resource will help researchers better understand the processes of genetic variation and the incidence of disease.
authors: Center of Bioinformatics, Key Laboratory for NeuroInformation of the Ministry of Education, University of Electronic Science and Technology of China, Chengdu, China.
authors: Wen
authors: W
authors: Wei
authors: Lu-Wen
authors: LW
authors: Ning
authors: Yuan-Nong
authors: YN
authors: Ye
authors: Shi-Jie
authors: SJ
authors: Li
authors: Hui-Qi
authors: HQ
authors: Zhou
authors: Jian
authors: J
authors: Huang
authors: Feng-Biao
authors: FB
authors: Guo
mesh_terms: D000818:Animals; D030541:Databases, Genetic; D004331:Drosophila melanogaster / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D019143:Evolution, Molecular; D005260:Female; D040961:Genetic Drift; D056084:Genetic Fitness; D023281:Genomics; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D008297:Male; D008957:Models, Genetic; D009154:Mutation; D012486:Salmonella typhimurium / Q000235:genetics
keywords: SMAL; database; mutation