title: Colorectal cancer, diabetes and survival: epidemiological insights.
abstract: Colorectal cancer (CRC) patients with pre-existing diabetes have significantly lower rates of overall survival compared with patients without diabetes. Against this backdrop, the American Diabetes Association and American Cancer Society in 2010 reviewed the scientific literature concerning diabetes and cancer. One of the key issues identified for further investigation was the need for a better understanding of whether diabetes influences cancer prognosis above and beyond the prognosis conferred by each disease state independently. Whether the worsened survival of CRC patients with diabetes could be explained by less favourable patient-, tumour- and treatment-related characteristics has also been evaluated in numerous recent studies. However, as most studies did not account for all the various potential confounders, such as cancer stage, comorbidities and body mass index (BMI) in their analyses, the current evidence for the association between diabetes and survival in CRC patients remains inconclusive. Nevertheless, based on multiple examples in the literature, the present review demonstrates that diabetes affects the presentation of CRC as well as its treatment and outcome, which may then result in lower overall rates of survival in patients with, compared to those without, diabetes.
authors: Eindhoven Cancer Registry, Comprehensive Cancer Centre South, Eindhoven, The Netherlands. Electronic address: research@ikz.nl.
authors: M M J
authors: MM
authors: Zanders
authors: Eindhoven Cancer Registry, Comprehensive Cancer Centre South, Eindhoven, The Netherlands; CoRPS-Centre of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.
authors: P A J
authors: PA
authors: Vissers
authors: Department of Internal Medicine, Máxima Medical Centre, Eindhoven/Veldhoven, The Netherlands.
authors: H R
authors: HR
authors: Haak
authors: Eindhoven Cancer Registry, Comprehensive Cancer Centre South, Eindhoven, The Netherlands; CoRPS-Centre of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, Tilburg, The Netherlands.
authors: L V
authors: LV
authors: van de Poll-Franse
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D017677:Age Distribution; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000276:immunology / Q000401:mortality* / Q000473:pathology; D015897:Comorbidity; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000401:mortality; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology
chemical_list: D000276:Adjuvants, Immunologic; D007004:Hypoglycemic Agents
keywords: Colorectal cancer; Diabetes; Overall survival; Review