title: Second primary mucosal malignant melanoma in hypopharynx.
abstract: Primary mucosal melanomas of the head and neck are rare. In addition, second primary mucosal melanoma following primary cutaneous malignant melanomas is very rare. We report a second primary mucosal melanoma. A 76-year-old woman, who had a previously cutaneous malignant melanoma of the left foot, visited with a complaint of a foreign body sensation of the throat. Endoscopy revealed a black mass at the left piriform sinus of the hypopharynx. After wide surgical excision of the lesion and reconstruction with a radial forearm free flap, the histopathology was confirmed to be a second primary mucosal malignant melanoma of the hypopharynx. Five months postoperatively, masses were palpated in the neck, and metastasis was diagnosed. The patient was treated with adjuvant chemotherapy and radiotherapy. Eight months postoperatively, computed tomography scans showed other metastatic masses in the liver, spleen, both adrenal glands, soft tissues of the abdominal wall, and both lungs. After that, the patient died 9 months postoperatively. We report a rare case of second primary mucosal malignant melanoma of the hypopharynx. Although rare, this case shows that a detailed examination of the hypopharynx and the head and neck should be a part of the follow-up examination in all cutaneous malignant melanoma patients.
authors: From the Departments of *Plastic and Reconstructive Surgery, †Otolaryngology-Head and Neck Surgery, and ‡Pathology, Soonchunhyang University College of Medicine, Seoul, Korea.
authors: Sang Gue
authors: SG
authors: Kang
authors: Chul Han
authors: CH
authors: Kim
authors: Min Sung
authors: MS
authors: Tark
authors: Chang Yong
authors: CY
authors: Choi
authors: Seo Yeong
authors: SY
authors: Wee
authors: Jae Wook
authors: JW
authors: Kim
authors: Yoon-Mi
authors: YM
authors: Jeen
mesh_terms: D000008:Abdominal Neoplasms / Q000556:secondary; D000310:Adrenal Gland Neoplasms / Q000556:secondary; D000368:Aged; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D005534:Foot Diseases / Q000473:pathology; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000175:diagnosis*; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis / Q000175:diagnosis; D008545:Melanoma / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D016609:Neoplasms, Second Primary / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000473:pathology; D013160:Splenic Neoplasms / Q000556:secondary; D000096142:Cutaneous Malignant Melanoma