title: [A clinical case of young, oral combined contraceptive using women, heterozygous carrier of the Factor V (Leiden) which revealed thrombosis of the left internal jugular vein and brain ischemia with cerebral infarction and ischemic stroke].
abstract: Thrombophilia is associated with increased risks of venous thrombosis in women taking oral contraceptive preparations. Universal thrombophilia screening in women prior to prescribing oral contraceptive preparations is not supported by current evidence. The case is presented of a 23 year-old women with a personal history of interruption and on the same day started with oral contraceptive (0.03 microg ethynil estradiol - 0.075 microg gestodene), which due on a 18 pill/day to acute headache, increasing vomiting and speaking defects. Physical/neurologic/gynecologic examinations observed a normal status. The MRI and CT revealed thrombosis of the left internal jugular vein and brain ischemia with cerebral infarction and ischemic stroke. The acute therapy of thrombotic findings was accompanied with many tests. The thrombophilia PCR-Real time - test finds heterozygous carrier of the Factor V (Leiden). This case shows the need of large prospective studies that should be undertaken to refine the risks and establish the associations of thrombophilias with venous thrombosis among contraceptive users. The key to a prompt diagnosis is to know the risk factors. The relative value of a thrombophilia screening programme before contraceptive using needs to be established.
authors: S
authors: S
authors: Kovachev
authors: K
authors: K
authors: Ramshev
authors: Z
authors: Z
authors: Ramsheva
authors: A
authors: A
authors: Ivanov
authors: A
authors: A
authors: Ganovska
mesh_terms: D002545:Brain Ischemia / Q000139:chemically induced* / Q000150:complications; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D005165:Factor V / Q000032:analysis*; D005260:Female; D006801:Humans; D007601:Jugular Veins / Q000473:pathology; D020521:Stroke / Q000139:chemically induced* / Q000150:complications; D019851:Thrombophilia / Q000139:chemically induced / Q000150:complications; D020246:Venous Thrombosis / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D055815:Young Adult
chemical_list: D003277:Contraceptives, Oral, Combined; C095381:factor V Leiden; D005165:Factor V