title: Expression of osteopontin in non-small cell lung cancer and correlative relation with microvascular density.
abstract: OBJECTIVE
  Lung cancer is one of the malignant diseases which most seriously threat humansurvival and development. This study aimed to assess osteopontin (OPN) expression in non-small cell lung cancer (NSCLC) and any relationship with clinicopathological features.
  
  
  METHODS
  Immunohistochemistry was used to determine OPN expression and microvascular density (MVD) in 120 cases of NSCLC also undergoing clinical assessment.
  
  
  RESULTS
  Moderately positive expression of OPN was found in 34.6% (41/120) and strong expression in 47.5% (57/120) of the NSCLCs; OPN expression in carcinomas was higher than in pericarcinoma tissues (P<0.05). While no obvious association was observed with NSCLC patient age, gender, maximum diameter of the tumor and pathological type, OPN expression was more commonly detected in poorly differentiated carcinoma tissue and lymph node metastasis as well as at advanced clinical stage (P<0.05); OPN expression in cancer tissue was positively correlated with MVD (r = 0.839, P = 0.000).
  
  
  CONCLUSIONS
  OPN plays an important role in promoting tumor angiogenesis and progress of NSCLCs and has the possibility to become the new target for therapy.
authors: Department of Chemotherapy, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, China E-mail : xjshanli@163.com.
authors: Ting-Ting
authors: TT
authors: Yu
authors: Zhi-Gang
authors: ZG
authors: Han
authors: Li
authors: L
authors: Shan
authors: Jie
authors: J
authors: Tao
authors: Tao
authors: T
authors: Zhang
authors: Shuai-Fei
authors: SF
authors: Yuan
authors: Hong-Li
authors: HL
authors: Shen
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply / Q000737:chemistry* / Q000556:secondary*; D005260:Female; D006801:Humans; D008168:Lung / Q000737:chemistry; D008175:Lung Neoplasms / Q000098:blood supply / Q000737:chemistry* / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D055806:Microvessels / Q000473:pathology*; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D053495:Osteopontin / Q000032:analysis*
chemical_list: D053495:Osteopontin