title: Hepatitis B and/or C co-infection in HIV infected patients: a study in a tertiary care centre from South India.
abstract: OBJECTIVE
  Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in human immunodeficiency virus (HIV) infected individuals results in increased hepatic complications. We undertook this study to evaluate the presence of HBV and HCV in HIV infected individuals attending a tertiary care centre in southern India.
  
  
  METHODS
  A total of 120 cases with HIV infection and 120 healthy adult control subjects were included in the study. Samples were tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies by enzyme linked immunosorbent assay (ELISA) method. HBsAg and anti-HCV positive serum samples were further tested for the presence of hepatitis B e antigen (HBeAg), anti-HBe antibodies, HBV-DNA and HCV-RNA.
  
  
  RESULTS
  The most common mode of transmission was sexual promiscuity (79%), followed by spouse positivity (15%) and history of blood transfusion (6%). HBsAg and anti-HCV were positive in 18 (15%) and 10 (8.3%) HIV infected patients; the corresponding figures in healthy controls being 2 (1.6%) 0 (0%) (P<0.0001). Among HIV infected patients, presence of HBeAg and anti-HBe antibodies was seen in 33.3 and 55.5 per cent, respectively; both HBeAg and anti-HBe antibodies were negative in 11.1 per cent. HBV DNA and HCV RNA were positive in 10 of 18 and in all anti-HCV positive samples. Triple infection with HBV, HCV and HIV was seen in three patients. CD4+ T-lymphocyte count less than 200/μl was seen in 22 of 28 co-infected cases.
  
  
  CONCLUSIONS
  The findings of our study showed presence of HBV (15%) and HCV (8.3%) co-infections in HIV positive patients which was higher than that seen in HIV negative controls. Co-infection with HBV and HCV is a common problem in HIV infected patients in India. Hence, all HIV patients need to be routinely tested for markers of HBV and HCV infection.
authors: Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad, India.
authors: Naval
authors: N
authors: Chandra
authors: Nayana
authors: N
authors: Joshi
authors: Y S N
authors: YS
authors: Raju
authors: Ajit
authors: A
authors: Kumar
authors: Vijay D
authors: VD
authors: Teja
mesh_terms: D000328:Adult; D060085:Coinfection / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D016174:Hepacivirus / Q000302:isolation & purification / Q000472:pathogenicity; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000302:isolation & purification / Q000472:pathogenicity; D006526:Hepatitis C / Q000150:complications / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D018937:Hepatitis C Antibodies / Q000302:isolation & purification; D006801:Humans; D007194:India; D008297:Male; D062606:Tertiary Care Centers
chemical_list: D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies