title: Asymmetric hydrogenation with iridium C,N and N,P ligand complexes: characterization of dihydride intermediates with a coordinated alkene.
abstract: Previously elusive iridium dihydride alkene complexes have been identified and characterized by NMR spectroscopy in solution. Reactivity studies demonstrated that these complexes are catalytically competent intermediates. Additional H2 is required to convert the catalyst-bound alkene into the hydrogenation product, supporting an Ir(III) /Ir(V) cycle via an [Ir(III) (H)2 (alkene)(H2 )(L)](+) intermediate, as originally proposed based on DFT calculations. NMR analyses indicate a reaction pathway proceeding through rapidly equilibrating isomeric dihydride alkene intermediates with a subsequent slow enantioselectivity-determining step. As in the classical example of asymmetric hydrogenation with rhodium diphosphine catalysts, it is a minor, less stable intermediate that is converted into the major product enantiomer.
authors: University of Basel, Department of Chemistry, St. Johanns-Ring 19, 4056 Basel (Switzerland).
authors: Stefan
authors: S
authors: Gruber
authors: Andreas
authors: A
authors: Pfaltz
keywords: hydrogenation; iridium; reaction mechanisms; reactive intermediates; structure elucidation