title: Rituximab for non-Hodgkin's lymphoma: a story of rapid success in translation.
abstract: Translational stories range from straightforward to complex. In this commentary, the story of the rapid and successful translation of rituximab therapy for the treatment of non-Hodgkin's lymphoma (NHL) is examined. Development of this monoclonal antibody therapy began in the late 1980s. In 1994, rituximab received its first approval for the treatment of NHL by the United States Food and Drug Administration (FDA). Rituximab has since been approved for additional indications and has transformed medical practice. However, the social and political implications of these rapid successes are only beginning to become clear. In this commentary, key events in the rapid translation of rituximab from the bench to bedside are highlighted and placed into this historical framework. To accomplish this, the story of rituximab is divided into the following six topics, which we believe to be widely applicable to case studies of translation: (1) underlying disease, (2) key basic science, (3) key clinical studies in translation, (4) FDA approval process, (5) changes to medical practice, and (6) the social and political influences on translation.
authors: Medical Scientist Training Program, Mayo Clinic, Rochester, Minnesota, USA.
authors: Andrew M
authors: AM
authors: Harrison
authors: Nassir M
authors: NM
authors: Thalji
authors: Alexandra J
authors: AJ
authors: Greenberg
authors: Carmen J
authors: CJ
authors: Tapia
authors: Anthony J
authors: AJ
authors: Windebank
mesh_terms: D000818:Animals; D058846:Antibodies, Monoclonal, Murine-Derived / Q000266:history* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000266:history* / Q000627:therapeutic use; D017277:Drug Approval / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007167:Immunotherapy / Q000266:history; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy*; D051379:Mice; D011057:Politics; D000069283:Rituximab; D012931:Social Environment; D057170:Translational Research, Biomedical / Q000266:history; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab
keywords: hematology; hematopathology; immunotherapy; leukemia; lymphoma; oncology