title: High fat diet aggravates arsenic induced oxidative stress in rat heart and liver.
abstract: Arsenic is a well known global groundwater contaminant. Exposure of human body to arsenic causes various hazardous effects via oxidative stress. Nutrition is an important susceptible factor which can affect arsenic toxicity by several plausible mechanisms. Development of modern civilization led to alteration in the lifestyle as well as food habits of the people both in urban and rural areas which led to increased use of junk food containing high level of fat. The present study was aimed at investigating the effect of high fat diet on heart and liver tissues of rats when they were co-treated with arsenic. This study was established by elucidating heart weight to body weight ratio as well as analysis of the various functional markers, oxidative stress biomarkers and also the activity of the antioxidant enzymes. Histological analysis confirmed the biochemical investigations. From this study it can be concluded that high fat diet increased arsenic induced oxidative stress.
authors: Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India; Department of Physiology, Vidyasagar College, Kolkata 700 006, India.
authors: Mousumi
authors: M
authors: Dutta
authors: Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
authors: Debosree
authors: D
authors: Ghosh
authors: Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
authors: Arnab Kumar
authors: AK
authors: Ghosh
authors: Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
authors: Gargi
authors: G
authors: Bose
authors: Department of Physiology, Vidyasagar College, Kolkata 700 006, India.
authors: Aindrila
authors: A
authors: Chattopadhyay
authors: Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
authors: Smita
authors: S
authors: Rudra
authors: Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
authors: Monalisa
authors: M
authors: Dey
authors: Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India.
authors: Arkita
authors: A
authors: Bandyopadhyay
authors: RN Tagore International Institute of Cardiac Sciences, 124, Mukundapur, E.M. Bypass, Kolkata 700 099, India.
authors: Sanjib K
authors: SK
authors: Pattari
authors: Acharya Prafulla Chandra Sikhsha Prangan, University of Calcutta, Salt Lake Campus, JD-2, Sector-III, Salt Lake City, Kolkata 700 098, India.
authors: Sanjaya
authors: S
authors: Mallick
authors: Oxidative Stress and Free Radical Biology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India; Centre with Potential for Excellence in Particular Area (CPEPA), University of Calcutta, University College of Science and Technology, 92, APC Road, Kolkata 700 009, India. Electronic address: debasish63@gmail.com.
authors: Debasish
authors: D
authors: Bandyopadhyay
mesh_terms: D000818:Animals; D001151:Arsenic / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D059305:Diet, High-Fat; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006334:Heart Function Tests; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D009929:Organ Size / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001151:Arsenic
keywords: Arsenic; Heart damage; High fat diet; Liver damage; Oxidative stress