title: Mathematical modeling approaches in the study of glaucoma disparities among people of African and European descents.
abstract: Open angle glaucoma (OAG) is a severe ocular disease characterized by progressive and irreversible vision loss. While elevated intraocular pressure (IOP) is a well-established risk factor for OAG, the progression of OAG in many cases, despite IOP treatment, suggests that other risk factors must play significant roles in the development of the disease. For example, various structural properties of the eye, ocular blood flow properties, and systemic conditions have been identified as risk factors for OAG. Ethnicity has also been indicated as a relevant factor that affects the incidence and prevalence of OAG; in fact, OAG is the leading cause of blindness among people of African descent. Numerous clinical studies have been designed to examine the possible correlation and causation between OAG and these factors; however, these studies are met with the challenge of isolating the individual role of multiple interconnected factors. Over the last decade, various mathematical modeling approaches have been implemented in combination with clinical studies in order to provide a mechanical and hemodynamical description of the eye in relation to the entire human body and to assess the contribution of single risk factors to the development of OAG. This review provides a summary of the clinical evidence of ocular structural differences, ocular vascular differences and systemic vascular differences among people of African and European descent, describes the mathematical approaches that have been proposed to study ocular mechanics and hemodynamics while discussing how they could be used to investigate the relevance to OAG of racial disparities, and outlines possible new directions of research.
authors: Department of Mathematical Sciences, Indiana University-Purdue University at Indianapolis, 402 N. Blackford St., Indianapolis, IN, 46202, USA ; Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, 1160 W. Michigan St., Indianapolis, IN, 46202, USA.
authors: Giovanna
authors: G
authors: Guidoboni
authors: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, 1160 W. Michigan St., Indianapolis, IN, 46202, USA.
authors: Alon
authors: A
authors: Harris
authors: Department of Mathematical Sciences, Indiana University-Purdue University at Indianapolis, 402 N. Blackford St., Indianapolis, IN, 46202, USA.
authors: Julia C
authors: JC
authors: Arciero
authors: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, 1160 W. Michigan St., Indianapolis, IN, 46202, USA.
authors: Brent A
authors: BA
authors: Siesky
authors: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, 1160 W. Michigan St., Indianapolis, IN, 46202, USA.
authors: Annahita
authors: A
authors: Amireskandari
authors: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, 1160 W. Michigan St., Indianapolis, IN, 46202, USA.
authors: Austin L
authors: AL
authors: Gerber
authors: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, 1160 W. Michigan St., Indianapolis, IN, 46202, USA.
authors: Andrew H
authors: AH
authors: Huck
authors: Eugene and Marilyn Glick Eye Institute, Indiana University School of Medicine, 1160 W. Michigan St., Indianapolis, IN, 46202, USA.
authors: Nathaniel J
authors: NJ
authors: Kim
authors: Department of Mathematical Sciences, Indiana University-Purdue University at Indianapolis, 402 N. Blackford St., Indianapolis, IN, 46202, USA.
authors: Simone
authors: S
authors: Cassani
authors: Department of Mathematical Sciences, Indiana University-Purdue University at Indianapolis, 402 N. Blackford St., Indianapolis, IN, 46202, USA.
authors: Lucia
authors: L
authors: Carichino
keywords: Blood Flow; Glaucoma; Mathematical Modeling; Ocular Hemodynamics; Ocular Mechanics