title: Kojic acid protects C57BL/6 mice from gamma-irradiation induced damage.
abstract: The radioprotective effects of a single administration of kojic acid (KA) against ionizing radiation were evaluated via assessment of 30-day survival and alterations of peripheral blood parameters of adult C57BL/6 male mice. The 30-day survival rate of mice pretreated with KA (75 or 300 mg/kg body weight, KA75 or KA300) subcutaneously 27 h prior to a lethal dose (8 Gy, 153.52 cGy/min) of gamma irradiation was higher than that of mice irradiated alone (40% or 60% vs 0%). It was observed that the white blood cell (WBC) count/the red blood cell (RBC) count, haemoglobin content, haematocrit and platelet count of mice with or without KA pretreatment as exposed to a sub-lethal dose (4 Gy, 148.14 cGy/min) of gamma irradiation decreased maximally at day 4/day 8 post-irradiation. Although the initial WBC values were low in KA300 or WR-2721 (amifostine) groups, they significantly recovered to normal at day 19, whereas in the control group they did not. The results from the cytotoxicity and cell viability assays demonstrated that KA could highly protect Chinese hamster ovary (CHO) cells against ionizing radiation with low toxicity. In summary, KA provides marked radioprotective effects both in vivo and in vitro.
authors: School of Graduate Studies, Anhui Medical University, Hefei, China E-mail : liuyx@nic.bmi.ac.cn.
authors: Kai
authors: K
authors: Wang
authors: Chao
authors: C
authors: Liu
authors: Chan-Juan
authors: CJ
authors: Di
authors: Cong
authors: C
authors: Ma
authors: Chun-Guang
authors: CG
authors: Han
authors: Mei-Ru
authors: MR
authors: Yuan
authors: Peng-Fei
authors: PF
authors: Li
authors: Lu
authors: L
authors: Li
authors: Yong-Xue
authors: YX
authors: Liu
mesh_terms: D004999:Amifostine / Q000008:administration & dosage; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D016466:CHO Cells; D049109:Cell Proliferation / Q000187:drug effects* / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004906:Erythrocyte Count; D005720:Gamma Rays; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count; D008297:Male; D008810:Mice, Inbred C57BL; D010976:Platelet Count; D011753:Pyrones / Q000008:administration & dosage*; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D015996:Survival Rate
chemical_list: D000975:Antioxidants; D006454:Hemoglobins; D011753:Pyrones; D011837:Radiation-Protective Agents; C011890:kojic acid; D004999:Amifostine