title: Applied choline-omics: lessons from human metabolic studies for the integration of genomics research into nutrition practice.
abstract: Nutritional genomics, defined as the study of reciprocal interactions among nutrients, metabolic intermediates, and the genome, along with other closely related nutritional -omic fields (eg, epigenomics, transcriptomics, and metabolomics) have become vital areas of nutrition study and knowledge. Utilizing results from human metabolic research on the essential nutrient choline, this article illustrates how nutrigenetic, nutrigenomic, and inter-related -omic research has provided new insights into choline metabolism and its effect on physiologic processes. Findings from highlighted choline research are also discussed in the context of translation to clinical and public health nutrition applications. Overall, this article underscores the utility of -omic research methods in elucidating nutrient metabolism as well as the potential for nutritional -omic concepts and discoveries to be broadly applied in nutritional practice.
authors: Allyson A
authors: AA
authors: West
authors: Marie A
authors: MA
authors: Caudill
mesh_terms: D002794:Choline / Q000378:metabolism*; D057890:Epigenomics; D005260:Female; D005838:Genotype; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D008659:Metabolic Diseases / Q000235:genetics*; D055432:Metabolomics; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics / Q000378:metabolism; D018977:Micronutrients / Q000008:administration & dosage; D054647:Nutrigenomics / Q000379:methods*; D009751:Nutritional Requirements; D009752:Nutritional Status; D011247:Pregnancy; D040901:Proteomics; D011634:Public Health; D059467:Transcriptome
chemical_list: D018977:Micronutrients; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D002794:Choline; D006854:Hydrocortisone
keywords: Choline; Epigenomic; Genomic; MTHFR; Nutrigenetic