title: Protective Effect of Agaricus brasiliensis on STZ-Induced Diabetic Neuropathic Pain in Rats.
abstract: Objective. The present investigation examined the neuroprotective effect of Agaricus brasiliensis (AbS) against STZ-induced diabetic neuropathic pain in laboratory rats. STZ-induced diabetic rats were administered orally with AbS. Body weight, serum glucose, and behavioral parameters were measured before and at the end of the experiment to see the effect of AbS on these parameters. After 6 weeks of treatments, all animals were sacrificed to study various biochemical parameters. Treatment with AbS 80 mg/kg in diabetic animals showed significant increase in body weight, pain threshold, and paw withdrawal threshold and significant decrease in serum glucose, LPO and NO level, Na-K-ATPase level, and TNF- α and IL-1 β level as compared to vehicle treated diabetic animals in dose and time dependent manner. AbS can offer pain relief in PDN. This may be of potential benefit in clinical practice for the management of diabetic neuropathy.
authors: Department of Orthopedics, Chinese Orthopedics and Traumatology Research Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China.
authors: Weifeng
authors: W
authors: Ji
authors: School of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
authors: Haiying
authors: H
authors: Huang
authors: School of Basic Medicine, Fujian Medical University, Fuzhou 350108, China.
authors: Ji
authors: J
authors: Chao
authors: Department of Orthopedics, Chinese Orthopedics and Traumatology Research Institute, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China.
authors: Wuchao
authors: W
authors: Lu
authors: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
authors: Jianyou
authors: J
authors: Guo