title: Teratogenic effects of coadministration of fluoxetine and olanzapine on rat fetuses.
abstract: Objective. Depression during pregnancy is a relatively common problem. Since little is known about the teratogenic effects of concomitant administration of fluoxetine and olanzapine during the organogenesis period, the aim of the present study was to evaluate the teratogenic effects of coadministration of fluoxetine and olanzapine on rat fetuses. Method. Forty-two pregnant rats were divided into seven groups, randomly. The first group received 0.5 mL of normal saline as the control. The second and third groups received fluoxetine at doses of 9 mg/kg and 18 mg/kg, respectively. Olanzapine was injected at 3 mg/kg and 6 mg/kg to the fourth and fifth groups, respectively. The sixth group received 9 mg/kg fluoxetine and 3 mg/kg olanzapine. Finally, the seventh group was administrated with fluoxetine and olanzapine at 18 mg/kg and 6 mg/kg, respectively. Drugs were injected intraperitoneally between day eight and day 15 of the pregnancy. On the 17th day of pregnancy, the fetuses were removed and micro-/macroscopically studied. Results. Fetuses of rats receiving high doses of these drugs showed a significant rate of cleft palate development, premature eyelid opening and torsion anomalies, compared to the control group (P ≤ 0.01). It is concluded that these drugs can lead to teratogenicity, so their concomitant use during pregnancy should be avoided, or if necessary their doses must be decreased.
authors: Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Pour Sina Street, Qods Street, Keshavarz Boulevard, Tehran 1417613151, Iran.
authors: Azam
authors: A
authors: Bakhtiarian
authors: Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran 1417613146, Iran.
authors: Nasrin
authors: N
authors: Takzare
authors: School of Medicine, Tehran University of Medical Sciences, Tehran 1417613110, Iran.
authors: Mehdi
authors: M
authors: Sheykhi
authors: Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors: Narges
authors: N
authors: Sistany
authors: Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Pour Sina Street, Qods Street, Keshavarz Boulevard, Tehran 1417613151, Iran.
authors: Farahnaz
authors: F
authors: Jazaeri
authors: Department of Veterinary Sciences, University of Pisa, San Piero a Grado, Pisa 56122, Italy.
authors: Mario
authors: 0000-0003-3657-4703
authors: M
authors: Giorgi
authors: Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Pour Sina Street, Qods Street, Keshavarz Boulevard, Tehran 1417613151, Iran.
authors: Vahid
authors: V
authors: Nikoui