title: Synthesis of Soai aldehydes for asymmetric autocatalysis by desulfurative cross-coupling.
abstract: Palladium-catalyzed dehydrosulfurative Liebeskind-Srogl coupling of terminal alkynes with 2-mercapto-1,3-pyrimidine-5-carbaldehyde under base-free conditions provides 2-(alkynyl)-1,3-pyrimidine-5-carbaldehydes, which are substrates for autocatalytic amplification of chirality according to Soai et al. The mercapto aldehyde acceptor is obtained by condensation of Arnold's vinamidinium salt with thiourea.
authors: Technische Universität München , Department Chemie, 85748 Garching bei München, Germany.
authors: Oleg V
authors: OV
authors: Maltsev
authors: Alexander
authors: A
authors: Pöthig
authors: Lukas
authors: L
authors: Hintermann