title: Memory regulatory T cells reside in human skin.
abstract: Regulatory T cells (Tregs), which are characterized by expression of the transcription factor Foxp3, are a dynamic and heterogeneous population of cells that control immune responses and prevent autoimmunity. We recently identified a subset of Tregs in murine skin with properties typical of memory cells and defined this population as memory Tregs (mTregs). Due to the importance of these cells in regulating tissue inflammation in mice, we analyzed this cell population in humans and found that almost all Tregs in normal skin had an activated memory phenotype. Compared with mTregs in peripheral blood, cutaneous mTregs had unique cell surface marker expression and cytokine production. In normal human skin, mTregs preferentially localized to hair follicles and were more abundant in skin with high hair density. Sequence comparison of TCRs from conventional memory T helper cells and mTregs isolated from skin revealed little homology between the two cell populations, suggesting that they recognize different antigens. Under steady-state conditions, mTregs were nonmigratory and relatively unresponsive; however, in inflamed skin from psoriasis patients, mTregs expanded, were highly proliferative, and produced low levels of IL-17. Taken together, these results identify a subset of Tregs that stably resides in human skin and suggest that these cells are qualitatively defective in inflammatory skin disease.
authors: Robert
authors: R
authors: Sanchez Rodriguez
authors: Mariela L
authors: ML
authors: Pauli
authors: Isaac M
authors: IM
authors: Neuhaus
authors: Siegrid S
authors: SS
authors: Yu
authors: Sarah T
authors: ST
authors: Arron
authors: Hobart W
authors: HW
authors: Harris
authors: Sara Hsin-Yi
authors: SH
authors: Yang
authors: Bryan A
authors: BA
authors: Anthony
authors: Francis M
authors: FM
authors: Sverdrup
authors: Elisabeth
authors: E
authors: Krow-Lucal
authors: Tippi C
authors: TC
authors: MacKenzie
authors: David S
authors: DS
authors: Johnson
authors: Everett H
authors: EH
authors: Meyer
authors: Andrea
authors: A
authors: Löhr
authors: Andro
authors: A
authors: Hsu
authors: John
authors: J
authors: Koo
authors: Wilson
authors: W
authors: Liao
authors: Rishu
authors: R
authors: Gupta
authors: Maya G
authors: MG
authors: Debbaneh
authors: Daniel
authors: D
authors: Butler
authors: Monica
authors: M
authors: Huynh
authors: Ethan C
authors: EC
authors: Levin
authors: Argentina
authors: A
authors: Leon
authors: William Y
authors: WY
authors: Hoffman
authors: Mary H
authors: MH
authors: McGrath
authors: Michael D
authors: MD
authors: Alvarado
authors: Connor H
authors: CH
authors: Ludwig
authors: Hong-An
authors: HA
authors: Truong
authors: Megan M
authors: MM
authors: Maurano
authors: Iris K
authors: IK
authors: Gratz
authors: Abul K
authors: AK
authors: Abbas
authors: Michael D
authors: MD
authors: Rosenblum
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D002465:Cell Movement; D049109:Cell Proliferation; D002478:Cells, Cultured; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D018859:Hair Follicle / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007156:Immunologic Memory; D020381:Interleukin-17 / Q000378:metabolism; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D008875:Middle Aged; D010641:Phenotype; D011565:Psoriasis / Q000276:immunology / Q000473:pathology; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D054400:Receptors, CCR7 / Q000378:metabolism; D012867:Skin / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism*; D055815:Young Adult
chemical_list: D015703:Antigens, CD; C515370:CCR7 protein, human; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D020381:Interleukin-17; D011948:Receptors, Antigen, T-Cell; D054400:Receptors, CCR7