title: Impact of laser-structured biomaterial interfaces on guided cell responses.
abstract: To achieve a perfect integration of biomaterials into the body, tissue formation in contact with the interface has to be controlled. In this connection, a selective cell control is required: fibrotic encapsulation has to be inhibited, while tissue guidance has to be stimulated. As conventional biomaterials do not fulfil this specification, functionalization of the biointerface is under development to mimic the natural environment of the cells. One approach focuses on the fabrication of defined surface topographies. Thereby, ultrashort pulse laser ablation is very beneficial, owing to a large variety of fabricated structures, reduced heat-affected zones, high precision and reproducibility. We demonstrate that nanostructures in platinum and microstructures in silicon selectively control cell behaviour: inhibiting fibroblasts, while stimulating neuronal attachment and differentiation. However, the control of fibroblasts strongly correlates with the created size dimensions of the surface structures. These findings suggest favourable biomaterial interfaces for electronic devices. The mechanisms which are responsible for selective cell control are poorly understood. To give an insight, cell behaviour in dependence of biomaterial interfaces is discussed-including basic research on the role of the extracellular matrix. This knowledge is essential to understand such specific cell responses and to optimize biomaterial interfaces for future biomedical applications.
authors: Laser Zentrum Hannover e.V. , Hollerithallee 8, 30419 Hannover , Germany.
authors: Elena
authors: E
authors: Fadeeva
authors: Laser Zentrum Hannover e.V. , Hollerithallee 8, 30419 Hannover , Germany.
authors: Andrea
authors: A
authors: Deiwick
authors: Laser Zentrum Hannover e.V. , Hollerithallee 8, 30419 Hannover , Germany ; Institute of Quantum Optics , Leibniz University Hannover , Welfengarten 1, 30167 Hannover , Germany.
authors: Boris
authors: B
authors: Chichkov
authors: Laser Zentrum Hannover e.V. , Hollerithallee 8, 30419 Hannover , Germany ; Institute of Quantum Optics , Leibniz University Hannover , Welfengarten 1, 30167 Hannover , Germany.
authors: Sabrina
authors: S
authors: Schlie-Wolter
keywords: biomaterial–cell interactions; nano- and microsized surface topographies; selective cell control; ultrashort pulse laser structuring