title: Long-term outcome of sensorineural hearing loss in nasopharyngeal carcinoma patients: comparison between treatment with radiotherapy alone and chemoradiotherapy.
abstract: The purpose of this study is to assess the long-term effect of sensorineural hearing loss (SNHL) resulted from radiotherapy (RT) alone versus chemoradiotherapy in nasopharyngeal carcinoma patients (NPC). Seventy-two patients initially diagnosed with NPC were enrolled from Shandong Tumor Hospital between March 2003 and May 2007. They were assigned into two groups: RT alone and chemoradiotherapy according to the different treatment regimens. Intensity-modulated radiation therapy was applied for both groups, concurrent and adjuvant cisplatin were administered for chemoradiotherapy group additionally. Hearing threshold test was performed at various time periods after completion of RT. Mean radiation dose to the cochlea in each ear was calculated to determine the correlation between cochlear dose and SNHL. We found that the hearing loss is more severe in the chemoradiotherapy group compared with RT group, from completion of RT up to the 5 years of follow-up period. This is especially obvious in the high frequency range. Hearing level is seriously damaged when cochlea dose exceeds 46 GY. We concluded that concurrent/adjuvant chemotherapy plus RT aggravates SNHL in NPC patients than RT alone and thus inner ear tissue tolerance should be redefined in those patients.
authors: Department of Radiation Oncology, Shandong's Key Laboratory of Radiation Oncology, Shandong Tumor Hospital, Jinan, 2250017, People's Republic of China.
authors: Yumei
authors: Y
authors: Wei
authors: Tao
authors: T
authors: Zhou
authors: Jian
authors: J
authors: Zhu
authors: Yi
authors: Y
authors: Zhang
authors: Mingping
authors: M
authors: Sun
authors: Xiuping
authors: X
authors: Ding
authors: Dongqing
authors: D
authors: Wang
authors: Hongsheng
authors: H
authors: Li
authors: Baosheng
authors: B
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001298:Audiology; D002277:Carcinoma; D059248:Chemoradiotherapy / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003051:Cochlea / Q000187:drug effects / Q000503:physiopathology / Q000528:radiation effects; D003131:Combined Modality Therapy / Q000009:adverse effects; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D011879:Radiotherapy Dosage; D012449:Safety; D013997:Time Factors; D055815:Young Adult