title: Vitamin D status and hypercholesterolemia in Spanish general population.
abstract: Low serum 25-hydroxyvitamin D [25(OH)D] levels have been associated with increased prevalence of cardiovascular diseases. A possible relation between lipids and 25(OH)D might explain this association. This investigation aimed to determine the association between vitamin D and cholesterol, as well as the influence of statins on this association. This was a cross-sectional population-based study with 177 subjects aged 18-84 years. We collected demographics and data on sun exposure, sun protection habits, current medication including lipid-lowering drugs, and estimated vitamin D intake. Serum measurements included levels of 25(OH)D, parathyroid hormone (PTH), calcium, phosphorus, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, and fasting glucose. The mean 25(OH)D level was 24 ± 9 ng/ml. Young age (P = 0.04) and spending more than 1 h outdoors (P = 0.04) were independently associated with higher 25(OH)D levels. The 25(OH)D concentrations correlated negatively with total cholesterol (P = 0.01) and LDL cholesterol (P = 0.04) levels. The adjusted OR for total cholesterol > 200 mg/ml was 2.8 (range, 1.1-7.5). Receiving statins was associated with higher 25(OH)D levels (P = 0.04). In conclusion, this study supports an association between 25(OH)D levels and cholesterol. Further studies are required to explain this association.
authors: Department of Dermatology, Hospital de la Vega Lorenzo Guirao, Cieza, Murcia, Spain.
authors: Eugenia
authors: E
authors: Cutillas-Marco
authors: Department of Dermatology, Hospital Universitario Doctor Peset, Valencia, Spain.
authors: Amparo Fuertes
authors: AF
authors: Prosper
authors: Sunlight, Nutrition, and Health Research Center, San Francisco, California, USA.
authors: William B
authors: WB
authors: Grant
authors: CIBER Epidemiología y Salud Pública (CIBERESP), Spain ; Unit of Public Health and Environmental Care, Department of Preventive Medicine, University of Valencia, Valencia, Spain ; Center for Public Health Research (CSISP), Valencia, Spain.
authors: María M
authors: MM
authors: Morales-Suárez-Varela
keywords: 25-hydroxyvitamin D; LDL cholesterol; cholesterol; lipids; statins; vitamin D