title: [Relationship of IFRD1-rs3807213 gene polymorphism with the risk of gastric cancer among Chinese].
abstract: OBJECTIVE
  To investigate the association between rs3807213 gene polymorphism in interferon related developmental regulator 1 gene (IFRD1) and the risk of gastric cancer among Chinese.
  
  
  METHODS
  There were 53 gastric cancer patients and 50 healthy people included in this case-control study. The blood samples were collected from each observed object and genotype (AA, AC, CC) of IFRD1 rs3807213 SNP was detected after polymerase chain reaction (PCR). The relationships of rs3807213 gene polymorphism with gastric cancer risk, clinic and pathologic features were analyzed.
  
  
  RESULTS
  Patients with stomach cancer had a significantly higher frequency of rs3807213 C allele distributions (OR = 3.759, 95% CI = 1.521-9.294; P = 0.003) than the controls. Compared with control group, patients with gastric cancer had a significantly higher frequency of rs3807213 CC genotype (OR = 4.028, 95% CI = 1.513-10.720; P = 0.004). When stratified by pathological stage of gastric cancer, there was no significant difference observed.
  
  
  CONCLUSIONS
  IFRD1-rs3807213 polymorphism may be associated with the increased risk of gastric cancer.
authors: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Chang-Bing
authors: CB
authors: Peng
authors: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Rui
authors: R
authors: Xu
authors: Department of Gastrointestinal Surgery, Sichuan Cancer Hospital, Chengdu 610047, China.
authors: Shuo-Meng
authors: SM
authors: Xiao
authors: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Wen
authors: W
authors: Zhuang
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*
chemical_list: C490045:IFRD1 protein, human; D017874:Immediate-Early Proteins