title: Emerging roles of microRNAs in neural stem cells.
abstract: Neural stem cells (NSCs) are a small subset of primitive precursors that generate and maintain the main phenotypes of the nervous system. Their ability to undergo long-term proliferation and neural differentiation endows them with great potential in regenerative medicine. Therefore, the mechanisms by which NSCs are regulated have been widely explored to improve their therapeutic efficacy in treating neurologic disorders. Recent progress has highlighted the significance of microRNAs (miRNAs) in the regulation of NSC behavior. Thus, to sketch out a comprehensive image of the regulatory mechanisms of miRNAs in NSCs, we here summarize existing evidence of the regulatory roles of diversified miRNAs in the proliferation and neural differentiation of NSCs during embryonic neurodevelopment and adult brain maintenance.
authors: Sheng
authors: S
authors: Wang
authors: Juan
authors: J
authors: Xu
authors: Rui
authors: R
authors: Ye
authors: Jing
authors: J
authors: Wang
authors: Zhaozhao
authors: Z
authors: Chen
authors: Renhuan
authors: R
authors: Huang
authors: Qiang
authors: Q
authors: Peng
authors: Yuanzhi
authors: Y
authors: Xu
authors: Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301, Middle Yanchang Road, Shanghai 200072, P.R. China. amyxyz01@hotmail.com.
authors: Xiaoxiao
authors: X
authors: Cai
mesh_terms: D000328:Adult; D001921:Brain / Q000166:cytology*; D002454:Cell Differentiation; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D058953:Neural Stem Cells / Q000166:cytology* / Q000378:metabolism; D044968:Regenerative Medicine
chemical_list: D035683:MicroRNAs