title: Electrochemiluminescence signal amplification combined with a conformation-switched hairpin DNA probe for determining the methylation level and position in the Hsp53 tumor suppressor gene.
abstract: We report a new strategy for detection of the methylation level and position in the Hsp53 tumor suppressor gene based on the electrochemiluminescence signal amplification combined with a conformation-switched hairpin DNA probe for improving selectivity.
authors: Jiangsu Key Laboratory of New Power Batteries, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China. zhangh@njnu.edu.cn cxcai@njnu.edu.cn.
authors: Hui
authors: H
authors: Zhang
authors: Meixing
authors: M
authors: Li
authors: Mengxing
authors: M
authors: Fan
authors: Jinxing
authors: J
authors: Gu
authors: Ping
authors: P
authors: Wu
authors: Chenxin
authors: C
authors: Cai
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry; D019175:DNA Methylation; D015342:DNA Probes / Q000737:chemistry*; D055664:Electrochemical Techniques; D031541:Fluorescence Resonance Energy Transfer; D016158:Genes, p53; D006046:Gold / Q000737:chemistry; D049449:Luminescence; D053768:Metal Nanoparticles / Q000737:chemistry; D009690:Nucleic Acid Conformation; D018036:Selenium Compounds / Q000737:chemistry; D020349:Surface Plasmon Resonance; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D019187:Cadmium Compounds; D015342:DNA Probes; D018036:Selenium Compounds; D016159:Tumor Suppressor Protein p53; D006046:Gold; C058667:cadmium selenide