title: The human papillomavirus (HPV) E6 oncoproteins promotes nuclear localization of active caspase 8.
abstract: The HPV-16 E6 and E6(⁎) proteins have been shown previously to be capable of regulating caspase 8 activity. We now show that the capacity of E6 to interact with caspase 8 is common to diverse HPV types, being also seen with HPV-11 E6, HPV-18 E6 and HPV-18 E6(⁎). Unlike most E6-interacting partners, caspase 8 does not appear to be a major proteasomal target of E6, but instead E6 appears able to stimulate caspase 8 activation, without affecting the overall apoptotic activity. This would appear to be mediated in part by the ability of the HPV E6 oncoproteins to recruit active caspase 8 to the nucleus.
authors: Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología, México/Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México. Av. San Fernando No. 22, Col. Sección XVI, Tlalpan 14080, Mexico.
authors: Joaquin
authors: J
authors: Manzo-Merino
authors: International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149 Trieste, Italy.
authors: Paola
authors: P
authors: Massimi
authors: Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología, México/Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México. Av. San Fernando No. 22, Col. Sección XVI, Tlalpan 14080, Mexico. Electronic address: lizanosoberon@gmail.com.
authors: Marcela
authors: M
authors: Lizano
authors: International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34149 Trieste, Italy. Electronic address: banks@icgeb.org.
authors: Lawrence
authors: L
authors: Banks
mesh_terms: D053181:Caspase 8 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002467:Cell Nucleus / Q000201:enzymology* / Q000235:genetics; D004789:Enzyme Activation; D052162:Human papillomavirus 16 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D030361:Papillomavirus Infections / Q000201:enzymology* / Q000235:genetics / Q000821:virology; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins; D053181:Caspase 8
keywords: Caspase 8; E6; HPV