title: The DJ-1 protein as a candidate biomarker in obstructive sleep apnea syndrome.
abstract: BACKGROUND
  Oxidative stress has a central role in the pathophysiology of obstructive sleep apnea syndrome (OSAS). The DJ-1 protein functions as a sensor of oxidative stress, acting both as a reactive oxygen species scavenger (ROS) and an antioxidative response regulator. The aim of our study is to determine the serum levels of DJ-1 in OSAS patients and assess possible correlations with their clinical, demographical, and biochemical characteristics.
  
  
  METHODS
  The study included 120 subjects from the Sleep Disorder Laboratory of the University Hospital of Thessaly (100 males vs 20 females, mean age 48±10, Apnea-Hypopnea Index (AHI)>5 episodes per hour of sleep). Subjects underwent full-night polysomnography (PSG) followed by morning blood sampling. Serum DJ-1 levels were determined via ELISA kits. Statistical analysis was performed using SPSS 19.
  
  
  RESULTS
  The median DJ-1 levels were 56.7 ng/mL (IQR, 34.9-99.3 ng/mL). Statistically significant correlations were detected between DJ-1's levels and AHI (Spearman's rho=0.189, P=0.04), Desaturation Index (DI; Spearman's rho=0.239, P=0.012), and serum low-density lipoprotein (LDL) (Spearman's rho=-0.205, P=0.042).
  
  
  CONCLUSIONS
  DJ-1 may be a useful biomarker in OSAS due to its correlations with AHI and DI. The correlation with serum LDL warrants further investigation regarding possible implications in OSAS patients' cardiovascular comorbidities.
authors: Department of Respiratory Medicine, University Hospital of Larissa, Biopolis, Larissa, Greece, dantevavougios@hotmail.com.
authors: George
authors: G
authors: Vavougios
authors: Chaido
authors: C
authors: Pastaka
authors: Irene
authors: I
authors: Tsilioni
authors: George
authors: G
authors: Natsios
authors: George
authors: G
authors: Seitanidis
authors: Evangelia
authors: E
authors: Florou
authors: Konstandinos I
authors: KI
authors: Gourgoulianis
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015513:Oncogene Proteins / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology*; D017286:Polysomnography; D000071617:Protein Deglycase DJ-1; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis*; D013223:Statistics as Topic
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1