title: Focal adhesion signaling in heart failure.
abstract: In this brief review, recent evidence is presented to indicate a role for specific components of the cardiomyocyte costamere (and its related structure the focal adhesion complex of cultured cardiomyocytes) in initiating and sustaining the aberrant signal transduction that contributes to myocardial remodeling and the progression to heart failure (HF). Special attention is devoted to the focal adhesion kinase family of nonreceptor protein tyrosine kinases in bidirectional signal transduction during cardiac remodeling and HF progression. Finally, some speculations and directions for future study are provided for this rapidly developing field of research.
authors: The Cardiovascular Institute and the Department of Medicine, Loyola University Chicago Stritch School of Medicine, Building 110, Rm 5222, 2160 South First Avenue, Maywood, IL, 60153, USA, asamare@lumc.edu.
authors: Allen M
authors: AM
authors: Samarel
mesh_terms: D000818:Animals; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D006333:Heart Failure / Q000378:metabolism*; D006801:Humans; D040542:Mechanotransduction, Cellular; D012518:Sarcomeres / Q000378:metabolism / Q000502:physiology
chemical_list: D051416:Focal Adhesion Protein-Tyrosine Kinases