title: The contribution of assessing cognitive impairment in radiologically-isolated syndrome (RIS): a single case report follow-up study.
abstract: Radiologically-isolated syndrome (RIS) is a recently-defined entity, described as the incidental discovery of lesions suggestive of multiple sclerosis (MS) on brain magnetic resonance imaging (MRI) scans demonstrating dissemination in space (DIS) without symptom expression and with a normal neurological examination. Recent studies demonstrate that RIS patients present similar features of cognitive impairment as MS patients. We describe a case of a RIS patient in whom investigating cognitive functions was a useful tool for diagnostic and therapeutic decisions.
authors: Multiple Sclerosis Center, Neurology Clinic, University of Udine Medical School, Italy luciodanna@hotmail.it.
authors: L
authors: L
authors: D'Anna
authors: Multiple Sclerosis Center, Neurology Clinic, University of Udine Medical School, Italy.
authors: S
authors: S
authors: Lorenzut
authors: Multiple Sclerosis Center, Neurology Clinic, University of Udine Medical School, Italy.
authors: A
authors: A
authors: Perelli
authors: Multiple Sclerosis Center, Neurology Clinic, University of Udine Medical School, Italy.
authors: B
authors: B
authors: Zanchettin
authors: Multiple Sclerosis Center, Neurology Clinic, University of Udine Medical School, Italy.
authors: M
authors: M
authors: Valente
authors: Multiple Sclerosis Center, Neurology Clinic, University of Udine Medical School, Italy.
authors: G L
authors: GL
authors: Gigli
mesh_terms: D058070:Asymptomatic Diseases; D001921:Brain / Q000473:pathology*; D002574:Cervical Vertebrae; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D005074:Evoked Potentials, Visual; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D033162:Incidental Findings; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000523:psychology; D009483:Neuropsychological Tests; D043025:Oligoclonal Bands / Q000134:cerebrospinal fluid; D013116:Spinal Cord / Q000473:pathology*
chemical_list: D043025:Oligoclonal Bands
keywords: Brain lesions; case study; cognitive impairment; early treatment; multiple sclerosis; neuropsychological testing; radiologically-isolated syndrome