title: Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst.
abstract: Four triterpenoid saponins (1-4) were isolated from Polycarpaea corymbosa Lamk. var. eriantha Hochst along with the known apoanagallosaponin IV (5). Their structures were elucidated by spectroscopic data analysis. Among the compounds 1, 3-5 which were evaluated for their cytotoxicity against three tumor cell lines (SW480, DU145 and EMT6), compound 1 exhibited cytotoxicity with IC50 values ranging from 4.61 to 22.61 μM, which was greater than that of etoposide. Compound 2 was tested only against SW480 and a cardiomyoblast cell line (H9c2), and was inactive.
authors: EA 4267 (FDE/UFC), Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
authors: Mahenina Jaovita
authors: MJ
authors: Manase
authors: EA 4267 (FDE/UFC), Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
authors: Anne-Claire
authors: AC
authors: Mitaine-Offer
authors: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors: Tomofumi
authors: T
authors: Miyamoto
authors: Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan.
authors: Chiaki
authors: C
authors: Tanaka
authors: Cohiro, UFR de Médecine de Dijon, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
authors: Stéphanie
authors: S
authors: Delemasure
authors: Cohiro, UFR de Médecine de Dijon, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
authors: Patrick
authors: P
authors: Dutartre
authors: EA 4267 (FDE/UFC), Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, 7, Bd. Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France. Electronic address: m-a.lacaille-dubois@u-bourgogne.fr.
authors: Marie-Aleth
authors: MA
authors: Lacaille-Dubois
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D029748:Caryophyllaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D012503:Saponins / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes
keywords: Caryophyllaceae; Cytotoxicity; NMR; Polycarpaea corymbosa; Triterpene saponins