title: Multifunctional hydrogels based on β-cyclodextrin with both biomineralization and anti-inflammatory properties.
abstract: In this study, a series of carboxylated hydrogels are synthesized using β-cyclodextrin, epichlorohydrin and succinic anhydride. It is found that the carboxyl groups on the β-cyclodextrin hydrogels could facilitate the biomineralization process in the simulated body fluid. The new generated minerals are apatite and similar to that of bones. Meanwhile, the carboxylated β-cyclodextrin hydrogels can also load and release anti-inflammatory drug (using indomethacin as a model) in a controlled manner during the biomineralization process for 28 days. The carboxylated β-cyclodextrin hydrogels also have low cytotoxicity and are promising for bone tissue engineering.
authors: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors: Sen
authors: S
authors: Liu
authors: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors: Xingyu
authors: X
authors: Chen
authors: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors: Qian
authors: Q
authors: Zhang
authors: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors: Wei
authors: W
authors: Wu
authors: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China.
authors: Jianyu
authors: J
authors: Xin
authors: College of Polymer Science and Engineering, Sichuan University, Chengdu 610065, China. Electronic address: jianshu_li@scu.edu.cn.
authors: Jianshu
authors: J
authors: Li
mesh_terms: D000327:Adsorption; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D019556:COS Cells; D002522:Chlorocebus aethiops; D020100:Hydrogels / Q000737:chemistry*; D007213:Indomethacin / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D020100:Hydrogels; D008903:Minerals; D047392:beta-Cyclodextrins; C031215:betadex; D007213:Indomethacin
keywords: Biomineralization; Bone tissue engineering; Cyclodextrin; Drug delivery system; Hydrogel