title: [Correlation between polymorphisms in the coagulation factor VII gene hypervariable region 4 site and the risk of coronary heart disease in population with different ethnic backgrounds: a Meta-analysis].
abstract: OBJECTIVE
  To assess the correlation between polymorphisms in the coagulation factor VII (F VII)gene hypervariable region 4 (HVR4)site and risk related to coronary heart disease (CHD)in different ethnic populations, especially the Asian populations.
  
  
  METHODS
  Publications up to April 2013, from CBM, CNKI, Wanfang Database,VIP, PubMed, Cochrane Library and Embase were searched to collect data from case-control studies related to F VII gene HVR4 site and CHD in populations from different ethnicities. Quality of studies was evaluated, available data extracted and both RevMan 5.1 and Stata 11.0 softwares were used for Meta-analysis.
  
  
  RESULTS
  Fifteen case-control studies were included, involving 3167 cases with CHD group and 3168 cases in the control group.
  
  
  RESULTS
  on this Meta-analysis showed that:a)polymorphism of the F VII gene HVR4 site H7/H6+H5 and CHD, b)H7H7/H6H6 + H7H6 and CHD were both slightly correlated between people with different ethnic backgrounds. However, the H6 allele versus H7+H5 allele and CHD showed different results-a high correlation seen in different ethnic groups. H5 allele versus H6+H7 allele and CHD did not appear significant difference(OR = 1.20, 95%CI:0.76-1.90, P = 0.43).
  
  
  CONCLUSIONS
  Both F VII gene HVR4 polymorphisms H7 allele and the H7H7 genotype might have served as protective factors for CHD in different ethnic groups, H6 allele might serve as a risk factor for CHD, but H5 allele was likely not to be associated with CHD in different ethnic groups.
authors: The Fist School of Clinical Medicine.
authors: Li-li
authors: LL
authors: Wang
authors: Evidence-based Medicine Center, Lanzhou University, Lanzhou 730000, China.
authors: Bin
authors: B
authors: Ma
authors: The Fist School of Clinical Medicine.
authors: Dun
authors: D
authors: Qian
authors: The Fist School of Clinical Medicine.
authors: Jun
authors: J
authors: Pang
authors: The Fist School of Clinical Medicine. Email: yaoyaliss@yahoo.cn.
authors: Ya-li
authors: YL
authors: Yao
mesh_terms: D000483:Alleles; D003327:Coronary Disease / Q000235:genetics*; D005167:Factor VII / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D005167:Factor VII