title: Curcumin and 5-fluorouracil-loaded, folate- and transferrin-decorated polymeric magnetic nanoformulation: a synergistic cancer therapeutic approach, accelerated by magnetic hyperthermia.
abstract: The efficient targeting and therapeutic efficacy of a combination of drugs (curcumin and 5-Fluorouracil [5FU]) and magnetic nanoparticles encapsulated poly(D,L-lactic-co-glycolic acid) nanoparticles, functionalized with two cancer-specific ligands are discussed in our work. This multifunctional, highly specific nanoconjugate resulted in the superior uptake of nanoparticles by cancer cells. Upon magnetic hyperthermia, we could harness the advantages of incorporating magnetic nanoparticles that synergistically acted with the drugs to destroy cancer cells within a very short period of time. The remarkable multimodal efficacy attained by this therapeutic nanoformulation offers the potential for targeting, imaging, and treatment of cancer within a short period of time (120 minutes) by initiating early and late apoptosis.
authors: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan.
authors: Sivakumar
authors: S
authors: Balasubramanian
authors: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan.
authors: Aswathy Ravindran
authors: AR
authors: Girija
authors: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan.
authors: Yutaka
authors: Y
authors: Nagaoka
authors: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan.
authors: Seiki
authors: S
authors: Iwai
authors: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan.
authors: Masashi
authors: M
authors: Suzuki
authors: Department of Respiratory Medicine, Sooriya Hospital, Chennai, India.
authors: Venugopal
authors: V
authors: Kizhikkilot
authors: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan.
authors: Yasuhiko
authors: Y
authors: Yoshida
authors: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan.
authors: Toru
authors: T
authors: Maekawa
authors: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Japan.
authors: Sakthikumar Dasappan
authors: SD
authors: Nair
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D017209:Apoptosis / Q000187:drug effects; D002460:Cell Line; D003131:Combined Modality Therapy; D003474:Curcumin / Q000008:administration & dosage*; D004337:Drug Carriers / Q000737:chemistry; D005472:Fluorouracil / Q000008:administration & dosage*; D005492:Folic Acid / Q000737:chemistry; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry; D061986:MCF-7 Cells; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D051379:Mice; D058726:Nanoconjugates / Q000008:administration & dosage / Q000737:chemistry; D050997:Nanomedicine; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014168:Transferrin / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D058185:Magnetite Nanoparticles; D058726:Nanoconjugates; D014168:Transferrin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005492:Folic Acid; D003474:Curcumin; D005472:Fluorouracil
keywords: 5FU; PLGA nanoparticle; curcumin; folate; magnetic hyperthermia; nanotechnology; transferrin