title: Apoliprotein E genotype is associated with apoliprotein B plasma levels but not with coronary calcium score in very elderly individuals in primary care setting.
abstract: BACKGROUND
  Epidemiological surveys indicate the influence of polymorphisms of apolipoprotein (apo) E on plasma lipids and triglyceride-rich lipoprotein levels, with impact on atherosclerotic phenotypes.
  
  
  OBJECTIVE
  We studied the association of classic genotypes of the apoE gene with clinical and biochemical risk factors for atherosclerosis in a segment of the very-old Brazilian individuals, with emphasis on the lipemic profile.
  
  
  METHODS
  We performed cross-sectional analyses of clinical and laboratory assessments, including cardiac computed tomography, across ε2, ε3 and ε4 carriers of the apoE gene with a convenience sample of 208 participants eligible for prevention against cardiovascular events.
  
  
  RESULTS
  When non-ε4 carriers were compared with ε4 carrying subjects, lower levels of ApoB as well as ApoB/ApoA ratios were observed in the former group. Tests between apoE polymorphisms with other clinical/biochemical variables and those with arterial calcification showed no significant differences between groups.
  
  
  CONCLUSIONS
  The study suggests a possible atherogenic role of the ε4 allele attributable to increased ApoB levels and ApoB/ApoA ratios among very-old subjects in primary care setting.
authors: Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: adrianedallanora@gmail.com.
authors: Adriane D
authors: AD
authors: Henriques
authors: Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: ac.tonet@uol.com.br.
authors: Audrey C
authors: AC
authors: Tonet-Furioso
authors: Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: wilcellymachado@gmail.com.
authors: Wilcelly
authors: W
authors: Machado-Silva
authors: Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil; Instituto de Cardiologia Biocardios, SEPS 709/909 Sul Edifício Biocenter, Asa Sul, 70.390-095 Brasília, DF, Brazil. Electronic address: wladimir.magalhaes@terra.com.br.
authors: Wladimir M
authors: WM
authors: Freitas
authors: Instituto de Cardiologia Biocardios, SEPS 709/909 Sul Edifício Biocenter, Asa Sul, 70.390-095 Brasília, DF, Brazil. Electronic address: luizquaglia@gmail.com.
authors: Luiz A
authors: LA
authors: Quaglia
authors: Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: sns2003@uol.com.br.
authors: Simone N
authors: SN
authors: Santos
authors: Universidade Católica de Brasília (UCB-DF), QS 07 Lote 01 EPCT, 71.966-700, Taguatinga, DF, Brazil. Electronic address: cordova@ucb.br.
authors: Cláudio
authors: C
authors: Córdova
authors: Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil; Universidade Estadual de Campinas (UNICAMP), Universidade Estadual de Campinas, Rua Tessália Vieira de Camargo 126, 13.083-887, Campinas, SP, Brazil. Electronic address: andreisposito@gmail.com.
authors: Andrei C
authors: AC
authors: Sposito
authors: Universidade de Brasília (UnB), Campus Universitário Darcy Ribeiro, 70.910-900 Brasília, DF, Brazil. Electronic address: otavionobrega@unb.br.
authors: Otávio T
authors: OT
authors: Nóbrega
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000097:blood* / Q000235:genetics*; D050197:Atherosclerosis / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D015415:Biomarkers / Q000097:blood*; D001938:Brazil; D002118:Calcium / Q000378:metabolism*; D003331:Coronary Vessels / Q000378:metabolism*; D003430:Cross-Sectional Studies; D004247:DNA / Q000097:blood / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011320:Primary Health Care; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D001057:Apolipoproteins E; D015415:Biomarkers; D004247:DNA; D002118:Calcium
keywords: Aging; Apolipoprotein; Atherosclerosis; Lipid metabolism; Primary prevention