title: Screening colonoscopy in first-degree relatives of patients with colorectal cancer.
abstract: BACKGROUND
  Colorectal cancer (CRC), one of the most important causes of morbidity and mortality, has earned the attention of healthcare systems widely. Screening programs are designed to detect patients at risk as effectively as possible. One of the major CRC risk factors is having a family member with diagnosed CRC.
  
  
  OBJECTIVE
  To investigate the association between presence of polyps on colonoscopy and family history of CRC.
  
  
  METHODS
  This was a retrospective cohort study in which the data was collected from colonoscopy reports of patients with/without familial history of CRC in Masoud private clinic, Tehran, Iran from October 1, 2011 to October 1, 2012. The association between presence of colorectal polyps on colonoscopy and family history of CRC was then assessed.
  
  
  RESULTS
  A total of 210 patients were included in the study, constituting two groups with/without familial history of CRC with a 1:1 ratio (105 subjects in each group). Compared to subjects with a negative family history of CRC, a 2.7-fold (CI 95%: 1.2-6.24) fold increase was observed in those with a positive family history to have colorectal polyps. In multivariate regression analysis, family history of CRC was the only independent variable associated with presence of colorectal polyps (odds ratio: 3.12, CI 95%:1.22-8).
  
  
  CONCLUSIONS
  A positive family history of CRC is a risk factor for colorectal polyps.
authors: Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.amir.ansari@gmail.com.
authors: Gilda
authors: G
authors: Barzin
authors: Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Mohammad Reza
authors: MR
authors: Ostovaneh
authors: Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Sirous
authors: S
authors: Tayebi
authors: Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Homayoun
authors: H
authors: Vahedi
authors: Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
authors: Reza
authors: R
authors: Ansari
mesh_terms: D000236:Adenoma / Q000175:diagnosis* / Q000235:genetics; D000328:Adult; D002277:Carcinoma / Q000175:diagnosis* / Q000235:genetics; D016022:Case-Control Studies; D015331:Cohort Studies; D003111:Colonic Polyps / Q000175:diagnosis* / Q000235:genetics; D003113:Colonoscopy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics; D055088:Early Detection of Cancer; D005190:Family; D005260:Female; D006801:Humans; D007492:Iran; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012189:Retrospective Studies