title: Preclinical screening for retinopathy of prematurity risk using IGF1 levels at 3 weeks post-partum.
abstract: Following current recommendations for preventing retinopathy of prematurity (ROP) involves screening a large number of patients. We performed a prospective study to establish a useful screening system for ROP prediction and we have determined that measuring serum levels of IGF1 at week three and the presence of sepsis have a high predictive value for the subsequent development of ROP. A total of 145 premature newborn, with birthweight <1500 g and/or <32 weeks gestational age, were enrolled. 26.9% of them showed some form of retinopathy. A significant association was found between the development of retinopathy and each of the following variables: early gestational age, low birthweight, requiring mechanical ventilation, oxygen treatment, intracranial haemorrhage, sepsis during the first three weeks, bronchopulmonary dysplasia, the need for erythrocyte transfusion, erythropoietin treatment, and low levels of serum IGF1 in the third week. A multiple logistic regression analysis was used to obtain curves for the probability of developing ROP, based on the main factors linked with ROP, namely serum levels of IGF1 and presence of sepsis. Such preclinical screening has the ability to identify patients with high-risk of developing retinopathy and should lead to better prediction for ROP, while at the same time optimising the use of clinical resources, both human and material.
authors: Neonatology Service, Department of Paediatrics, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: Alejandro
authors: A
authors: Pérez-Muñuzuri
authors: Neonatology Service, Department of Paediatrics, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: Maria Luz
authors: ML
authors: Couce-Pico
authors: Neonatology Service, Department of Paediatrics, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: Ana
authors: A
authors: Baña-Souto
authors: Neonatology Service, Department of Paediatrics, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: Olalla
authors: O
authors: López-Suárez
authors: Neonatology Service, Department of Paediatrics, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: Alicia
authors: A
authors: Iglesias-Deus
authors: Ophthalmology Service, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: José
authors: J
authors: Blanco-Teijeiro
authors: Neonatology Service, Department of Paediatrics, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: José Ramón
authors: JR
authors: Fernández-Lorenzo
authors: Neonatology Service, Department of Paediatrics, Clinical Hospital of the University of Santiago de Compostela, Santiago de Compostela, Spain.
authors: José María
authors: JM
authors: Fraga-Bermúdez
mesh_terms: D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D015997:Neonatal Screening / Q000379:methods; D009885:Ophthalmology; D010100:Oxygen / Q000737:chemistry; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012044:Regression Analysis; D012121:Respiration, Artificial; D012178:Retinopathy of Prematurity / Q000097:blood / Q000175:diagnosis*; D012307:Risk Factors; D018805:Sepsis / Q000097:blood*
chemical_list: D007334:Insulin-Like Growth Factor I; D010100:Oxygen