title: Ulcerative colitis and immunoglobulin G4.
abstract: OBJECTIVE
  Ulcerative colitis (UC) is sometimes associated with autoimmune pancreatitis (AIP). Infiltration of immunoglobulin G4 (IgG4)-positive plasma cells is sometimes detected in the colonic mucosa of AIP or UC patients. This study aimed to clarify the relation between UC and IgG4.
  
  
  METHODS
  Associations with UC were reviewed in 85 AIP patients. IgG4 immunostaining was performed on biopsy specimens from the colonic mucosa of 14 AIP and 32 UC patients.
  
  
  RESULTS
  UC was confirmed in two cases (type 1 AIP, n=1; suspected type 2 AIP, n=1). Abundant infiltration of IgG4-positive plasma cells in the colonic mucosa was detected in the case of suspected type 2 AIP with UC and two cases of type 1 AIP without colitis. Abundant infiltration of IgG4-positive plasma cells was detected in 10 UC cases (IgG4-present, 31%). Although 72% of IgG4-absent UC patients showed mild disease activity, 70% of IgG4-present patients showed moderate to severe disease activity (p<0.05).
  
  
  CONCLUSIONS
  UC is sometimes associated with AIP, but it seems that UC is not a manifestation of IgG4-related disease. Infiltration of IgG4-positive plasma cells is sometimes detectable in the colonic mucosa of UC patients and is associated with disease activity.
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Go
authors: G
authors: Kuwata
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Terumi
authors: T
authors: Kamisawa
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Koichi
authors: K
authors: Koizumi
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Taku
authors: T
authors: Tabata
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Seiichi
authors: S
authors: Hara
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Sawako
authors: S
authors: Kuruma
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Takashi
authors: T
authors: Fujiwara
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Kazuro
authors: K
authors: Chiba
authors: Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Hideto
authors: H
authors: Egashira
authors: Department of Endoscopy, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Junko
authors: J
authors: Fujiwara
authors: Department of Endoscopy, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Takeo
authors: T
authors: Arakawa
authors: Department of Endoscopy, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Kumiko
authors: K
authors: Momma
authors: Department of Pathology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
authors: Shinichiro
authors: S
authors: Horiguchi
mesh_terms: D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000097:blood* / Q000150:complications; D003106:Colon / Q000737:chemistry*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007413:Intestinal Mucosa / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood* / Q000150:complications; D012189:Retrospective Studies
chemical_list: D007074:Immunoglobulin G
keywords: Autoimmune pancreatitis; Colitis, ulcerative; Immunoglobulin G