title: FOLFIRINOX as first-line treatment for unresectable acinar cell carcinoma of the pancreas: a case report.
abstract: Pancreatic acinar cell carcinoma (ACC) is a rare, aggressive variant of pancreatic ductal adenocarcinoma. Surgery is the only curative treatment option and protocols for palliative chemotherapies in this context are not standardized yet. We reported a 63-year-old white male patient who had painless jaundice, weight loss, elevated bilirubin, and a mass of the pancreatic head as well as liver metastasis. Core biopsy revealed the diagnosis of ACC. Therapy with FOLFIRINOX resulted in a significant decrease of the primary tumor and regressiveness of a liver metastasis after chemotherapy. Our report suggests that pancreatic ACC treated by FOLFIRINOX is well tolerated and might be superior to other single chemotherapies in this rare tumor disease.
authors: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany.
authors: U
authors: U
authors: Schempf
authors: Institute of Pathology, University of Tuebingen, Tuebingen, Germany.
authors: B
authors: B
authors: Sipos
authors: Department for Diagnostic and Interventional Radiology, University of Tuebingen, Tuebingen, Germany.
authors: C
authors: C
authors: König
authors: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany.
authors: N P
authors: NP
authors: Malek
authors: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany.
authors: M
authors: M
authors: Bitzer
authors: Department of Internal Medicine I, Medical University Hospital, Tuebingen, Germany.
authors: R R
authors: RR
authors: Plentz
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018267:Carcinoma, Acinar Cell / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D000077146:Irinotecan; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000077146:Irinotecan; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin