title: An unusual case of flecainide-induced QT prolongation leading to cardiac arrest.
abstract: Flecainide is recommended as a first-line antiarrhythmic drug to maintain normal sinus rhythm in patients with atrial fibrillation (AF) who have structurally normal hearts or hypertension without left ventricular hypertrophy. Flecainide is a sodium channel blocker with minimal effects expected on ventricular repolarization. We describe the case of a 32-year-old man with a structurally normal heart and persistent AF who was started on diltiazem and flecainide 50 mg twice/day approximately a year prior to presentation. Due to persistent and bothersome symptoms, his dose was increased to 150 mg twice/day, which was associated with a progressive lengthening of his corrected QT interval. On the day of presentation, he underwent an exercise test as part of his job requirements. While running, he felt lightheaded and experienced a syncopal event and cardiac arrest. An automated external defibrillator was available that displayed polymorphic ventricular tachycardia. The patient was successfully resuscitated. Although rare, this case suggests that flecainide can induce QT prolongation leading to torsades de pointes. Clinicians should be aware and consider periodic evaluations with electrocardiograms.
authors: Department of Internal Medicine, Baylor Scott & White Healthcare, Temple, Texas; College of Medicine, Texas A&M University Health Science Center, Temple, Texas.
authors: Kevin N
authors: KN
authors: Oguayo
authors: Ola O
authors: OO
authors: Oyetayo
authors: Steven M
authors: SM
authors: Costa
authors: Timothy A
authors: TA
authors: Mixon
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000652:urine; D001281:Atrial Fibrillation / Q000188:drug therapy; D047548:Defibrillators; D005424:Flecainide / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006323:Heart Arrest / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced* / Q000628:therapy; D008297:Male; D012151:Resuscitation; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D005424:Flecainide
keywords: QT interval; antiarrhythmic drugs; atrial fibrillation; flecainide; torsades de pointes