title: Are hypertriglyceridemia and low HDL causal factors in the development of insulin resistance?
abstract: Insulin resistance often occurs with dyslipidemia as part of the metabolic syndrome and the current dominant paradigm is that insulin resistance leads to dyslipidemia. However, dyslipidemia may also cause insulin resistance; this was postulated 30 years ago, but has never been substantiated. Establishing whether dyslipidemia plays a causal role in the etiology of insulin resistance is important since it could reveal new avenues for combating type 2 diabetes. In this review we summarize recent evidence from epidemiological, genetic and intervention studies to re-address this old hypothesis.
authors: University of Groningen, University Medical Center Groningen, Department of Molecular Genetics, Groningen, The Netherlands; Department of Endocrinology, Key Laboratory of Endocrinology of Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.
authors: Naishi
authors: N
authors: Li
authors: University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, The Netherlands.
authors: Jingyuan
authors: J
authors: Fu
authors: University of Groningen, University Medical Center Groningen, Department of Molecular Genetics, Groningen, The Netherlands.
authors: Debby P
authors: DP
authors: Koonen
authors: University of Groningen, University Medical Center Groningen, Department of Molecular Genetics, Groningen, The Netherlands.
authors: Jan Albert
authors: JA
authors: Kuivenhoven
authors: University of Groningen, University Medical Center Groningen, Department of Epidemiology, Genetic Epidemiology & Bioinformatics Unit, Groningen, The Netherlands.
authors: Harold
authors: H
authors: Snieder
authors: University of Groningen, University Medical Center Groningen, Department of Molecular Genetics, Groningen, The Netherlands. Electronic address: M.H.Hofker@umcg.nl.
authors: Marten H
authors: MH
authors: Hofker
mesh_terms: D008076:Cholesterol, HDL / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D050171:Dyslipidemias / Q000150:complications; D055106:Genome-Wide Association Study; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D015228:Hypertriglyceridemia / Q000150:complications; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology*; D024821:Metabolic Syndrome / Q000150:complications
chemical_list: D008076:Cholesterol, HDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
keywords: Dyslipidemia; HDL-cholesterol; Insulin resistance; Triglycerides