title: Changes in the retrobulbar arterial circulation after decrease of the elevated intraocular pressure in men and women with primary open angle glaucoma.
abstract: BACKGROUND
  An altered perfusion of the optic nerve head has been proposed as a pathogenic factor of glaucoma.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the changes of the hemodynamic parameters in the retrobulbar arterial circulation after decrease of the elevated intraocular pressure (IOP) in women and men with primary open angle glaucoma.
  
  
  METHODS
  The study included 60 patients (33 males and 27 females) older than 50 years, with diagnosed and treated primary open angle glaucoma (77 eyes of 39 patients had increased IOP, > 25 mm Hg).They were examined at the Clinic of Eye Diseases (complete ophthalmologic exam) and Clinic of Neurology, Clinical Center of Serbia, Belgrade, from December 2009 to December 2010. Imaging of hemodynamic parameters of three retrobulbar arterial vessels: ophthalmic, central retinal and posterior ciliary arteries with color Doppler was performed.
  
  
  RESULTS
  Among women, hemodynamic arterial parameter of the peak-systolic velocity was increased in the central retinal artery and decreased in the ophthalmic artery and posterior ciliary arteries; end-diastolic velocity was increased in all three retrobulbar vascular levels; Pourcelot resistivity index was increased, but pulsatility index was decreased in all three vessels. Among men, peak-systolic velocity, end-diastolic velocity and pulsatility index were decreased in all three vessels; resistivity index was increased in the ophthalmic artery, but decreased in the central retinal artery and posterior ciliary arteries. There was a significant change of the ophthalmic artery pulsatility index in women, and the end-diastolic velocity of the ophthalmic artery in men.
  
  
  CONCLUSIONS
  There was a difference of the retrobulbar arterial circulation between women and men with primary open angle glaucoma after decrease of the elevated intraocular pressure.The role of vascular factors in the supply of the optic disc neuroretinal rim is important.
authors: School of Medicine, University of Belgrade, Belgrade, Serbia. ivanmarjanovic007@yahoo.com
authors: Ivan
authors: I
authors: Marjanović
authors: Instituto Gallego de Oftalmologia, Clinical Research Department, Science Research and Sports, Santiago de Compostela, La Coruna, Spain.
authors: Antonio
authors: A
authors: Martinez
authors: School of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Marija
authors: M
authors: Marjanović
authors: School of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Djordje
authors: D
authors: Kontić
authors: School of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Paraskeva
authors: P
authors: Hentova-Senćanić
authors: School of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Vujica
authors: V
authors: Marković
authors: School of Medicine, University of Belgrade, Belgrade, Serbia.
authors: Marija
authors: M
authors: Bozić
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D001783:Blood Flow Velocity; D005123:Eye; D005260:Female; D005902:Glaucoma, Open-Angle / Q000503:physiopathology* / Q000628:therapy; D006439:Hemodynamics; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009880:Ophthalmic Artery / Q000503:physiopathology*; D009898:Optic Disk / Q000098:blood supply*; D009915:Orbit / Q000098:blood supply; D011446:Prospective Studies; D011465:Prostaglandins, Synthetic / Q000627:therapeutic use; D012039:Regional Blood Flow; D012161:Retinal Artery / Q000503:physiopathology*; D055771:Serbia; D012737:Sex Factors; D014065:Tonometry, Ocular; D014130:Trabeculectomy; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D011465:Prostaglandins, Synthetic