title: Shape analysis of the corpus callosum in Alzheimer's disease and frontotemporal lobar degeneration subtypes.
abstract: Morphology of the corpus callosum is a useful biomarker of neuronal loss, as different patterns of cortical atrophy help to distinguish between dementias such as Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). We used a sophisticated morphometric analysis of the corpus callosum in FTLD subtypes including frontotemporal dementia (FTD), semantic dementia (SD), and progressive non-fluent aphasia (PNFA), and compared them to AD patients and 27 matched controls. FTLD patient subgroups diverged in their callosal morphology profiles, with FTD patients showing marked widespread differences, PNFA patients with differences largely in the anterior half of the callosum, and SD patients differences in a small segment of the genu. AD patients showed differences in predominantly posterior callosal regions. This study is consistent with our previous findings showing significant cortical and subcortical regional atrophy across FTLD subtypes, and suggests that callosal atrophy patterns differentiate AD from FTLD, and FTLD subtypes.
authors: Neuropsychiatry Unit, Royal Melbourne Hospital and Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Australia.
authors: Mark
authors: M
authors: Walterfang
authors: Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA.
authors: Eileen
authors: E
authors: Luders
authors: Research Centre for Neurosciences of Ageing, Academic Unit of Psychiatry and Addiction Medicine, Australian National University Medical School, Canberra, Australia Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
authors: Jeffrey C L
authors: JC
authors: Looi
authors: Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA.
authors: Priya
authors: P
authors: Rajagopalan
authors: Neuropsychiatry Unit, Royal Melbourne Hospital and Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Melbourne, Australia.
authors: Dennis
authors: D
authors: Velakoulis
authors: Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA Department of Neurology, Psychiatry, Radiology, Pediatrics, Engineering & Ophthalmology, University of Southern California, Los Angeles, CA, USA USC Imaging Genetics Center, Marina del Rey, CA, USA.
authors: Paul M
authors: PM
authors: Thompson
authors: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
authors: Olof
authors: O
authors: Lindberg
authors: Division of Speech-Language Pathology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, and Department of Speech-Language Pathology, Karolinska University Hospital, Stockholm, Sweden.
authors: Per
authors: P
authors: Ostberg
authors: Hospital Physics, Karolinska University Hospital, Hospital Physics and Radiology, Huddinge, Stockholm, Sweden.
authors: Love E
authors: LE
authors: Nordin
authors: Hospital Physics, Karolinska University Hospital, Hospital Physics and Radiology, Huddinge, Stockholm, Sweden.
authors: Leif
authors: L
authors: Svensson
authors: Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden.
authors: Lars-Olof
authors: LO
authors: Wahlund
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000145:classification* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D012189:Retrospective Studies
keywords: Alzheimer's disease; corpus callosum; frontotemporal dementia; white matter