title: Circadian glomerular function: from physiology to molecular and therapeutical aspects.
abstract: Life on earth is rhythmic by essence due to day/night alternation, and many biological processes are also cyclic. The kidney has a special role in the organism, controlling electrolytes and water balance, blood pressure, elimination of metabolic waste and xenobiotics and the production of several hormones. The kidney is submitted to changes throughout 24 h with periods of intense activity followed by calmer periods. Filtration, reabsorption and secretion are the three components determining renal function. Here, we review circadian changes related to glomerular function and proteinuria and emphasize the role of the clock in these processes.
authors: Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland.
authors: Grégoire
authors: G
authors: Wuerzner
authors: Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
authors: Dmitri
authors: D
authors: Firsov
authors: Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland Department of Pharmacology and Toxicology, University of Lausanne, Lausanne, Switzerland.
authors: Olivier
authors: O
authors: Bonny
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D019468:Disease Management; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D011507:Proteinuria / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy
keywords: circadian clock; glomerular filtration; kidney; proteinuria