title: A method of inducing global cerebral ischemia.
abstract: The four-vessel occlusion (4-VO) method of global forebrain cerebral ischemia mimics the human clinical condition of cardiac arrest. It results in selective neuronal damage and is a useful experimental system to dissect underlying mechanisms behind ischemic phenomena such as the differential susceptibility of CA1 compared to the CA3 region of the hippocampus. It also provides a "proof-of-principle" system for testing out potential agents for neuroprotection.
authors: Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
authors: Gina
authors: G
authors: Hadley
authors: Michalis
authors: M
authors: Papadakis
authors: Alastair M
authors: AM
authors: Buchan
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000209:etiology*; D004195:Disease Models, Animal; D006323:Heart Arrest / Q000150:complications*; D008297:Male; D051381:Rats; D017208:Rats, Wistar