title: Synthesis of carboxymethyl chitosan and coating on wound dressing gauze for wound healing.
abstract: Wound healing is a long and complex process. To improve wound healing, the wound dressing cotton gauze can be functionalized by imparting moisture holding and antibacterial ability. Moisture is an important factor for wound healing and the absence of microbial intervention can accelerate wound healing process. Direct alkylation method was used to synthesis carboxymethylated chitosan with water solubility, biocompatibility and antibacterial activity. Calcium alginate was used along with modified chitosan as moisture gaining polymeric agent. Pad-dry-cure method was employed to coat both the polymers on cotton gauze surface, which was weaved using 40s Ne cotton yarn. After coating, the cotton was analysed for its polymer add-on percentage, antibacterial action against Staphylococcus aureus ATCC 6538 and Escherichia coli ATCC 10229. The persistence analysis of antibacterial activity ensures the polymer withstanding ability on cotton gauze surface. SEM detection of polymers with cotton threads confirms their presence. Wound healing action of the polymer coated cotton gauze was determined using albino rats as animal model.
authors: Department of Microbiology and Bioinformatics, CMS College of Science and Commerce, Coimbatore, Tamil Nadu, India.
authors: B
authors: B
authors: Venkatrajah
authors: Department of Zoology, Kunthavai Nachiar Government College for Women, Tanjore, Tamil Nadu, India.
authors: V Vanitha
authors: VV
authors: Malathy
authors: Department of Microbiology and Bioinformatics, CMS College of Science and Commerce, Coimbatore, Tamil Nadu, India.
authors: B
authors: B
authors: Elayarajah
authors: Department of Microbiology, PSG College of Arts and Science, Coimbatore, Tamil Nadu, India.
authors: R
authors: R
authors: Rajendran
authors: Department of Microbiology and Bioinformatics, CMS College of Science and Commerce, Coimbatore, Tamil Nadu, India.
authors: Ram
authors: R
authors: Rammohan
mesh_terms: D000464:Alginates / Q000737:chemistry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology*; D001458:Bandages; D048271:Chitosan / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D020099:Coated Materials, Biocompatible; D032561:Cotton Fiber; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005260:Female; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D051381:Rats; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013997:Time Factors; D014867:Water / Q000737:chemistry; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000464:Alginates; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D006603:Hexuronic Acids; C514968:carboxymethyl-chitosan; D014867:Water; D020723:Glucuronic Acid; D048271:Chitosan