title: Alterations in platelet function during aging: clinical correlations with thromboinflammatory disease in older adults.
abstract: Platelets have a dynamic functional repertoire that mediates hemostatic and inflammatory responses. Many of these functions are altered in older adults, promoting a prothrombotic, proinflammatory milieu and contributing to risk of adverse clinical events. Drawing primarily from human studies, this review summarizes important aspects of aging-related changes in platelets. The relationship between altered platelet functions and thrombotic and inflammatory disorders in older adults is highlighted. Established and developing antiplatelet therapies for the treatment of thrombotic and inflammatory disorders are also discussed in light of these data.
authors: Divisions of General Internal Medicine, Department of Internal Medicine, Health Sciences Center, University of Utah, Salt Lake City, Utah.
authors: Donya
authors: D
authors: Mohebali
authors: David
authors: D
authors: Kaplan
authors: McKenzie
authors: M
authors: Carlisle
authors: Mark A
authors: MA
authors: Supiano
authors: Matthew T
authors: MT
authors: Rondina
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood*; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000209:etiology; D010974:Platelet Aggregation; D013927:Thrombosis / Q000097:blood* / Q000209:etiology
keywords: aging; inflammation; monocyte; platelet; thrombosis