title: Lapatinib and letrozole as first-line therapy for metastatic breast cancer: case report of bone metastasis 18 years later.
abstract: We describe a 63-year-old woman with a diagnosis of breast cancer who relapsed with multiple bone lesions 18 years later. The biological characteristics were estrogen receptor positive, progesterone receptor positive, and HER2-positive cancer. Lapatinib and letrozole was the treatment of choice as a manageable and active first-line therapy for this patient.
authors: Gabriella
authors: G
authors: Mariani
authors: Francesca
authors: F
authors: Ricchini
authors: Lorenzo
authors: L
authors: Sica
authors: Giulia Valeria
authors: GV
authors: Bianchi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood*; D001858:Bone Nails; D001859:Bone Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000556:secondary*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000556:secondary*; D005260:Female; D005264:Femoral Fractures / Q000517:prevention & control; D006801:Humans; D019394:Ki-67 Antigen / Q000097:blood; D000077341:Lapatinib; D000077289:Letrozole; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009367:Neoplasm Staging; D009570:Nitriles / Q000008:administration & dosage; D010146:Pain / Q000209:etiology; D059408:Pain Management; D011799:Quinazolines / Q000008:administration & dosage; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000097:blood; D011980:Receptors, Progesterone / Q000097:blood; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D000077341:Lapatinib; D000077289:Letrozole; D009570:Nitriles; D011799:Quinazolines; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014230:Triazoles; C508053:ERBB2 protein, human