title: The comparison of the effects of sevoflurane inhalation anesthesia and intravenous propofol anesthesia on oxidative stress in one lung ventilation.
abstract: BACKGROUND
  The aim of this study is to compare the effects of sevoflurane and propofol on one lung ventilation (OLV) induced ischemia-reperfusion injury (IRI) by determining the blood gas, ischemia-modified albumin (IMA), and malonyldialdehyde (MDA).
  
  
  METHODS
  Forty-four patients undergoing thoracic surgery with OLV were randomized in two groups (sevoflurane Group S, propofol Group P). Anesthesia was inducted with thiopental and was maintained with 1-2.5% of sevoflurane within the 40/60% of O2/N2O mixture in Group S. In Group P anesthesia was inducted with propofol and was maintained with infusion of propofol and remifentanil. Hemodynamic records and blood samples were obtained before anesthesia induction (t 1), 1 min before two lung ventilation (t 2), 30 min after two lung ventilation (t 3), and postoperative sixth hours (t 4).
  
  
  RESULTS
  Heart rate at t 2 and t 3 in Group P was significantly lower than that in Group S. While there were no significant differences in terms of pH and pCO2, pO2 at t 2 and t 3 in Group S was significantly lower than that in Group P. IMA levels at t 4 in Group S were significantly lower than those in Group P.
  
  
  CONCLUSIONS
  Sevoflurane may offer protection against IRI after OLV in thoracic surgery.
authors: Department of Anesthesiology and Intensive Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Engin
authors: E
authors: Erturk
authors: Department of Anesthesiology and Intensive Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Selma
authors: S
authors: Topaloglu
authors: Department of Anesthesiology and Intensive Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Davut
authors: D
authors: Dohman
authors: Department of Anesthesiology and Intensive Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Dilek
authors: D
authors: Kutanis
authors: Department of Anesthesiology and Intensive Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Ahmet
authors: A
authors: Beşir
authors: Department of Anesthesiology and Intensive Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Yucel
authors: Y
authors: Demirci
authors: Department of Anesthesiology and Intensive Care, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Selcuk
authors: S
authors: Kayir
authors: Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors: Ahmet
authors: A
authors: Mentese
mesh_terms: D061605:Administration, Intravenous; D000293:Adolescent; D000368:Aged; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D008875:Middle Aged; D061810:One-Lung Ventilation; D018384:Oxidative Stress / Q000187:drug effects*; D015742:Propofol / Q000008:administration & dosage*; D015427:Reperfusion Injury / Q000097:blood / Q000473:pathology / Q000601:surgery*; D000077149:Sevoflurane
chemical_list: D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol