title: [Application of gene therapy to oncologic ophthalmology].
abstract: Since the discovery of the structure of DNA in 1953 by Watson and Crick, our understanding of the genetic causes and the regulations involved in tumor development have hugely increased. The important amount of research developed since then has led to the development of gene therapy, which specifically targets and treats cancer cells by interacting with, and correcting their genetic material. This study is a review of the most accomplished research using gene therapy aimed at treating malignant ophthalmologic diseases, and focuses more specifically on uveal melanoma and retinoblastoma. Such approaches are remarkable regarding the efficiency and the cellular targeting specificity. However, gene therapy-based treatments are so recent that many long-term interrogations subsist. The majority of the reviewed studies are conducted in vitro or in murine models, thereby requiring several years before the resulting therapies become part of the daily ophthalmologists' arsenal. However, the recent spectacular developments based on advanced scientific knowledge justify an up-to-date review that would benefit the ophthalmologist community.
authors: Clinique ophtalmologique universitaire, hôpital de la Croix-Rousse, 103, Grande-rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France.
authors: A
authors: A
authors: Philiponnet
authors: Clinique ophtalmologique universitaire, hôpital de la Croix-Rousse, 103, Grande-rue-de-la-Croix-Rousse, 69317 Lyon cedex 04, France.
authors: J-D
authors: JD
authors: Grange
authors: UMR5305, laboratoire de biologie tissulaire & ingénierie thérapeutique (LBTI), CNRS UCBL, 7, Passage-du-Vercors, 69367 Lyon cedex 07, France. Electronic address: lg.baggetto@ibcp.fr.
authors: L G
authors: LG
authors: Baggetto
mesh_terms: D000818:Animals; D005134:Eye Neoplasms / Q000235:genetics / Q000628:therapy*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000008:administration & dosage; D006801:Humans; D007167:Immunotherapy / Q000379:methods / Q000639:trends; D008081:Liposomes; D008545:Melanoma / Q000628:therapy; D013508:Ophthalmologic Surgical Procedures / Q000379:methods* / Q000639:trends*; D019572:Retinal Neoplasms / Q000628:therapy; D012175:Retinoblastoma / Q000628:therapy; D014604:Uveal Neoplasms / Q000628:therapy; D000098943:Uveal Melanoma
chemical_list: D008081:Liposomes
keywords: Gene therapy; Mélanome uvéal; Onco-ophtalmologie; Oncologic ophthalmology; Retinoblastoma; Review; Rétinoblastome; Thérapie génique; Uveal melanoma