title: Transcription factors involved in brassinosteroid repressed gene expression and their regulation by BIN2 kinase.
abstract: Brassinosteroids (BRs) play important roles in plant growth, development and responses to environmental cues. BRs signal through plasma membrane-localized receptors to control BES1/BZR1 family transcription factors, which mediate the expression of thousands of genes. BRs activate and repress approximately equal numbers of genes. BES1/BZR1 interact with other transcription factors, histone-modifying enzymes, and transcription elongation factors to activate BR-induced genes. However, the mechanisms by which BES1/BZR1 mediate the BR-repressed gene expression are not well understood. Recent studies revealed that 2 BR-repressed transcription factors, MYBL2 and HAT1, cooperate with BES1 to downregulate BR-repressed genes expression. Moreover, BIN2 kinase, a well-established negative regulator in the BR signaling pathway, phosphorylates MYBL2 and HAT1. While BIN2 phosphorylates and destabilizes BES1/BZR1, BIN2 phosphorylated MYBL2 and HAT1 appear to be stabilized. These results not only extended our understanding of BR-repressed gene expression, but also revealed multiple inputs of BR signaling into BR transcriptional networks.
authors: College of Life Science; Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment; State Key Laboratory of Hydraulics and Mountain River Engineering; Sichuan University; Chengdu, PR China; Department of Genetics; Development and Cell Biology; Iowa State University; Ames, IA USA.
authors: Dawei
authors: D
authors: Zhang
authors: Department of Genetics; Development and Cell Biology; Iowa State University; Ames, IA USA.
authors: Huaxin
authors: H
authors: Ye
authors: Department of Genetics; Development and Cell Biology; Iowa State University; Ames, IA USA.
authors: Hongqing
authors: H
authors: Guo
authors: Department of Genetics; Development and Cell Biology; Iowa State University; Ames, IA USA.
authors: Abbagail
authors: A
authors: Johnson
authors: College of Life Science; Ministry of Education Key Laboratory for Bio-Resource and Eco-Environment; State Key Laboratory of Hydraulics and Mountain River Engineering; Sichuan University; Chengdu, PR China.
authors: Honghui
authors: H
authors: Lin
authors: Department of Genetics; Development and Cell Biology; Iowa State University; Ames, IA USA.
authors: Yanhai
authors: Y
authors: Yin
mesh_terms: D017360:Arabidopsis / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000378:metabolism*; D060406:Brassinosteroids / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D051548:Histone Acetyltransferases; D009687:Nuclear Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D029681:Arabidopsis Proteins; D060406:Brassinosteroids; D004268:DNA-Binding Proteins; D051548:Histone Acetyltransferases; D009687:Nuclear Proteins; D011494:Protein Kinases; D014157:Transcription Factors; C103684:AtmybL2 protein, Arabidopsis; C456160:BES1 protein, Arabidopsis; C000593713:HAC1 protein, Arabidopsis; C448985:At4g18710 protein, Arabidopsis
keywords: Arabidopsis thaliana; BES1; BIN2; Brassinosteroids; HAT1; MYBL2; phosphorylation; protein stability; signaling