title: Inhibitory effects of juglanin on cellular senescence in human dermal fibroblasts.
abstract: Cellular senescence contributes to tissue and organismal aging, tumor suppression and progress, tissue repair and regeneration, and age-related diseases. Thus, aging intervention might be a promising target for treatment and prevention of diverse age-related diseases. In the present study, we investigated whether juglanin purified from the crude extract of Polygonum aviculare exerted inhibitory activity against cellular senescence in human dermal fibroblasts (HDFs). Juglanin decreased senescence-associated β-galactosidase activity (SA-β-gal) and the level of reactive oxygen species in senescent cells induced by adriamycin treatment. Juglanin also repressed SA-β-gal activity in HDFs under replicative senescence. These results suggest that juglanin represses cellular senescence in HDFs and might be useful for the development of dietary supplements or cosmetics that alleviate tissue aging or age-related diseases.
authors: Department of Biochemistry and Molecular Biology, College of Medicine, Yeungnam University, 317-1 Daemyung-Dong, Daegu, 705-717, Republic of Korea.
authors: Hyo Hyun
authors: HH
authors: Yang
authors: Kyoung
authors: K
authors: Hwangbo
authors: Ming Shan
authors: MS
authors: Zheng
authors: Jong-Keun
authors: JK
authors: Son
authors: Hwa Young
authors: HY
authors: Kim
authors: Suk Hwan
authors: SH
authors: Baek
authors: Hyung Chul
authors: HC
authors: Choi
authors: So Young
authors: SY
authors: Park
authors: Jae-Ryong
authors: JR
authors: Kim
mesh_terms: D002478:Cells, Cultured; D016922:Cellular Senescence / Q000187:drug effects*; D020405:Dermis / Q000166:cytology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D044949:Kaempferols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028502:Polygonum / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism
chemical_list: D006027:Glycosides; D044949:Kaempferols; D017382:Reactive Oxygen Species; C000590800:juglanin; D001616:beta-Galactosidase