title: Impact of dispersed fuel oil on cardiac mitochondrial function in polar cod Boreogadus saida.
abstract: In this study, impact of dispersed oil on cardiac mitochondrial function was assessed in a key species of Arctic marine ecosystem, the polar cod Boreogadus saida. Mature polar cod were exposed during 48 h to dispersed oil (mechanically and chemically) and dispersants alone. The increase observed in ethoxyresorufin-O-deethylase activity and polycyclic aromatic hydrocarbon metabolites in bile indicated no difference in contamination level between fish exposed to chemical or mechanical dispersion of oil. Oil induced alterations of O2 consumption of permeabilised cardiac fibres showing inhibitions of complexes I and IV of the respiratory chain. Oil did not induce any modification of mitochondrial proton leak. Dispersants did not induce alteration of mitochondrial activity and did not increase oil toxicity. These data suggest that oil exposure may limit the fitness of polar cod and consequently could lead to major disruption in the energy flow of polar ecosystem.
authors: Laboratoire ORPHY EA4324, Université de Bretagne Occidentale, 6 Avenue le Gorgeu, CS 93 837, 29 238, Brest Cedex 3, France, Matthieu.Dussauze@cedre.fr.
authors: Matthieu
authors: M
authors: Dussauze
authors: Lionel
authors: L
authors: Camus
authors: Stéphane
authors: S
authors: Le Floch
authors: Karine
authors: K
authors: Pichavant-Rafini
authors: Perrine
authors: P
authors: Geraudie
authors: Nathalie
authors: N
authors: Coquillé
authors: Aline
authors: A
authors: Amérand
authors: Philippe
authors: P
authors: Lemaire
authors: Michael
authors: M
authors: Theron
mesh_terms: D000818:Animals; D001110:Arctic Regions; D001646:Bile / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D029941:Fish Proteins / Q000378:metabolism*; D005648:Fuel Oils / Q000009:adverse effects* / Q000032:analysis; D048388:Gadiformes / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D010578:Petroleum / Q000032:analysis / Q000378:metabolism*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000378:metabolism
chemical_list: D015415:Biomarkers; D029941:Fish Proteins; D005648:Fuel Oils; D010578:Petroleum; D011084:Polycyclic Aromatic Hydrocarbons; D014874:Water Pollutants, Chemical; D019363:Cytochrome P-450 CYP1A1