title: Prevalence, specificity and functionality of anti-ganglioside antibodies in neuropathy associated with IgM monoclonal gammopathy.
abstract: IgM antibodies against gangliosides and their complexes were studied in sera from 54 patients with polyneuropathy and IgM monoclonal gammopathy (IgM-PNP) without anti-MAG antibodies. Anti-ganglioside antibodies were found in 19 (35%) patients. Five (9%) patients had antibodies against ganglioside complexes. IgM antibodies against gangliosides activated complement in vitro. Light chain usage was restricted to kappa or lambda in most, but not all patients. In conclusion, anti-ganglioside antibodies in IgM-PNP are common, display pathogenic properties and do not always arise from a monoclonal B cell proliferation.
authors: Brain Center Rudolf Magnus, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands. Electronic address: astork2@umcutrecht.nl.
authors: Abraham C J
authors: AC
authors: Stork
authors: Department of Neurology and Immunology, Erasmus Medical Center, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors: Bart C
authors: BC
authors: Jacobs
authors: Department of Neurology and Immunology, Erasmus Medical Center, s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands.
authors: Anne P
authors: AP
authors: Tio-Gillen
authors: Department of Neurology, Spaarne Ziekenhuis, Spaarnepoort 1, 2134 TM Hoofddorp, The Netherlands.
authors: Marijke
authors: M
authors: Eurelings
authors: Brain Center Rudolf Magnus, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors: Marc D
authors: MD
authors: Jansen
authors: Brain Center Rudolf Magnus, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors: Leonard H
authors: LH
authors: van den Berg
authors: Brain Center Rudolf Magnus, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors: Nicolette C
authors: NC
authors: Notermans
authors: Brain Center Rudolf Magnus, University Medical Center, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
authors: W-Ludo
authors: WL
authors: van der Pol
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000918:Antibody Specificity / Q000276:immunology; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D015153:Blotting, Western; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D011115:Polyneuropathies / Q000097:blood / Q000276:immunology*; D015995:Prevalence
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D005732:Gangliosides; D007075:Immunoglobulin M
keywords: Ganglioside; Hematologic disease; Immunology; Monoclonal gammopathy of unknown significance; Peripheral neuropathy