title: Polytetrafluoroethylene expanded prosthesis as replacement of the inferior vena cava in renal cell carcinoma with caval thrombus.
abstract: OBJECTIVE
  To assess the outcomes of inferior vena cava replacement with polytetrafluoroethylene expanded prosthesis in patients with renal cell carcinoma and caval thrombosis.
  
  
  METHODS
  All patients who underwent radical nephrectomy with inferior vena cava replacement by polytetrafluoroethylene expanded prosthesis for renal cancer associated with inferior vena cava thrombosis and a suspicion of inferior vena cava wall invasion from January 2000 to June 2011 were considered for this study. Demographic data, postoperative course, graft patency and survival data were evaluated.
  
  
  RESULTS
  A total of 26 patients (median age 59.5 years, range 19.9-85.6 years) were included in the analysis. The median tumor diameter was 10 cm (range 5-14 cm). Histological invasion of the wall of the inferior vena cava was found in 16 (61.5%) cases. The median follow up was 28 months (range 1-136). A graft thrombosis occurred in five (19.2%) patients within the first year. Four of these patients died before the end of the second year. Patency of the inferior vena cava graft at 6 and 12 months was 88% and 79%, respectively. Overall survival probability at 3 years was 64%.
  
  
  CONCLUSIONS
  Prosthetic replacement of the inferior vena cava can be carried out when invasion of the wall of the inferior vena cava is suspected. The postoperative complication rate in this subset of high-risk patients undergoing radical nephrectomy seems acceptable, and the patency of the prostheses is good in most of the cases.
authors: Department of Urology, University of Lille Nord de France, Lille, France.
authors: Ahmed
authors: A
authors: Benkirane
authors: Muhieddine
authors: M
authors: Khodari
authors: Rachid
authors: R
authors: Yakoubi
authors: Marc
authors: M
authors: Lambert
authors: Mohamad
authors: M
authors: Koussa
authors: Tarek
authors: T
authors: Ghoneim
authors: Stephan
authors: S
authors: Haulon
authors: Arnauld
authors: A
authors: Villers
authors: Laurent
authors: L
authors: Lemaitre
authors: Laurent
authors: L
authors: Zini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001807:Blood Vessel Prosthesis; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000556:secondary / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating; D011138:Polytetrafluoroethylene; D011474:Prosthesis Design; D012189:Retrospective Studies; D013927:Thrombosis / Q000209:etiology*; D014682:Vena Cava, Inferior / Q000601:surgery*; D055815:Young Adult
chemical_list: D011138:Polytetrafluoroethylene
keywords: inferior vena cava; polytetrafluoroethylene; polytetrafluoroethylene expanded prosthesis; renal cell carcinoma; vena cava thrombosis