title: Comparative study of peripheral blood leukocytes in healthy dogs and in dogs with cancer and inflammatory diseases.
abstract: In the present study, the peripheral blood lymphocyte subset distribution was compared between healthy dogs and dogs with chronic gastrointestinal disease, dental and skin conditions, and cancer. The immunophenotype of the group with chronic gastrointestinal disease and the group with dental and skin conditions showed no statistically significant differences with other groups of healthy or diseased dogs. When compared with healthy dogs, animals with cancer showed significantly lower absolute values of T cytotoxic cells (CD3+, CD8+) and lymphocytes that express major histocompatibility complex (MHC) class II (MHC-II+) in peripheral blood. The results suggest that peripheral blood immunophenotype is mainly altered in dogs with cancer but not in other diseases. Further studies are required to evaluate the clinical relevance of these findings.
authors: 1Mercedes García-Sancho, Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, Complutense University of Madrid, Avenida Puerta de Hierro s/n, 28040 Madrid, Spain. mercgarc@vet.ucm.es.
authors: Mercedes
authors: M
authors: García-Sancho
authors: Alejandra
authors: A
authors: Villaescusa
authors: Fernando
authors: F
authors: Rodríguez-Franco
authors: Angel
authors: A
authors: Sainz
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology*; D016022:Case-Control Studies; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D007249:Inflammation / Q000473:pathology / Q000662:veterinary*; D009369:Neoplasms / Q000473:pathology / Q000662:veterinary*; D016176:T-Lymphocyte Subsets / Q000502:physiology*
keywords: Canine; disease; lymphocyte subsets