title: The effect of lacosamide on bone tissue in orchidectomised male albino Wistar rats.
abstract: OBJECTIVE
  While most antiepileptic drugs (AEDs) have been associated with various adverse effects on bone health, for the recently introduced lacosamide (LCM) no corresponding data have been published. The present study evaluates the effect of LCM on bone mineral density, bone turnover markers, and bone mechanical strength in a rat model.
  
  
  METHODS
  16 orchidectomized Wistar rats were divided into control and experimental groups, 8 rats each. Dual energy X-ray absorptiometry was used to measure bone mineral density (BMD). As bone metabolism markers, the concentrations of bone markers were assayed in bone homogenate. In addition, both femurs were measured and used for biomechanical testing.
  
  
  RESULTS
  Compared to the control group, we found lower BMD in the experimental group in the area of the left (8%) as well as the right femur (12%), all differences being statistically significant. In both femur diaphyses, but not in lumbar vertebrae, BMD was lower in the LCM group, suggesting a preferential effect on cortical bone. However, neither the thickness of the diaphyseal cortical bone nor the fragility in biomechanical testing was different between the groups. Of the bone metabolism markers, the significant decline was in procollagen type I N-terminal peptide (PINP) levels (37.4%), suggesting a decrease in osteoid synthesis.
  
  
  CONCLUSIONS
  We assume then that long-lasting exposure to LCM can represent a certain risk to the health of bone in the setting of gonadal insufficiency. Further studies will be needed to confirm these findings and to determine how high the risk will be in comparison to the other AEDs.
authors: Department of Neurology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove, Czech Republic.
authors: Julius
authors: J
authors: Simko
authors: Institute of Clinical Biochemistry and Diagnostics, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove.
authors: Sona
authors: S
authors: Fekete
authors: Institute of Clinical Biochemistry and Diagnostics, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove.
authors: Jana
authors: J
authors: Malakova
authors: Department of Pathophysiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove.
authors: Jan
authors: J
authors: Kremlacek
authors: 4th Department of Internal Medicine - Hematology, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove.
authors: Jiri
authors: J
authors: Horacek
authors: Radioisotope Laboratories and Vivarium, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove.
authors: Helena
authors: H
authors: Zivna
authors: Institute of Clinical Biochemistry and Diagnostics, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove.
authors: Vladimir
authors: V
authors: Palicka
authors: Institute of Clinical Biochemistry and Diagnostics, Faculty of Medicine in Hradec Kralove, Charles University in Prague and University Hospital Hradec Kralove.
authors: Pavel
authors: P
authors: Zivny
mesh_terms: D015502:Absorptiometry, Photon; D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001696:Biomechanical Phenomena; D015519:Bone Density; D001842:Bone and Bones / Q000187:drug effects* / Q000503:physiopathology; D004195:Disease Models, Animal; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D005269:Femur / Q000378:metabolism; D000078334:Lacosamide; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000081:Acetamides; D000927:Anticonvulsants; D000078334:Lacosamide
keywords: antiepileptic drugs; biomechanical strength; bone markers; bone mineral density; bone turnover