title: The role of neuroimaging in predicting neurodevelopmental outcomes of preterm neonates.
abstract: Magnetic resonance imaging (MRI) is a safe and high-resolution neuroimaging modality that is increasingly used in the neonatal population to assess brain injury and its consequences on brain development. It is superior to cranial ultrasound for the definition of patterns of both white and gray matter maturation and injury and therefore has the potential to provide prognostic information on the neurodevelopmental outcomes of the preterm population. Furthermore, the development of sophisticated MRI strategies, including diffusion tensor imaging, resting state functional connectivity, and magnetic resonance spectroscopy, may increase the prognostic value, helping to guide parental counseling and allocate early intervention services.
authors: Department of Pediatrics, Yale University School of Medicine, 1 Park Street, West Pavilion, New Haven, CT 06510, USA.
authors: Soo Hyun
authors: SH
authors: Kwon
authors: The Division of Development and Growth, Department of Paediatrics, Children's Hospital Geneva, 6 rue Willy Donzé, 1211 Geneva, Switzerland.
authors: Lana
authors: L
authors: Vasung
authors: Department of Pediatrics, Yale University School of Medicine, 1 Park Street, West Pavilion, New Haven, CT 06510, USA; Department of Pediatric Neurology, Yale University School of Medicine, 1 Park Street, West Pavilion, New Haven, CT 06510, USA.
authors: Laura R
authors: LR
authors: Ment
authors: The Division of Development and Growth, Department of Paediatrics, Children's Hospital Geneva, 6 rue Willy Donzé, 1211 Geneva, Switzerland. Electronic address: petra.huppi@hcuge.ch.
authors: Petra S
authors: PS
authors: Huppi
mesh_terms: D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002658:Developmental Disabilities / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D056324:Diffusion Tensor Imaging / Q000379:methods; D004453:Echoencephalography / Q000379:methods; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007969:Leukomalacia, Periventricular / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000000981:diagnostic imaging / Q000473:pathology*; D059906:Neuroimaging / Q000379:methods; D011379:Prognosis
keywords: DEHSI; DTI; MRI; Neurodevelopmental outcome; Periventricular leukomalacia; Preterm brain injury; White matter injury; fMRI