title: Progress toward an efficient panel of SNPs for ancestry inference.
abstract: Many panels of ancestry informative single nucleotide polymorphisms have been proposed in recent years for various purposes including detecting stratification in biomedical studies and determining an individual's ancestry in a forensic context. All of the panels have limitations in their generality and efficiency for routine forensic work. Some panels have used only a few populations to validate them. Some panels are based on very large numbers of SNPs thereby limiting the ability of others to test different populations. We have been working toward an efficient and globally useful panel of ancestry informative markers that is comprised of a small number of highly informative SNPs. We have developed a panel of 55 SNPs analyzed on 73 populations from around the world. We present the details of the panel and discuss its strengths and limitations.
authors: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA. Electronic address: kenneth.kidd@yale.edu.
authors: Kenneth K
authors: KK
authors: Kidd
authors: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA.
authors: William C
authors: WC
authors: Speed
authors: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA.
authors: Andrew J
authors: AJ
authors: Pakstis
authors: Life Technologies, 1149 Chess Drive, Foster City, CA 94404, USA.
authors: Manohar R
authors: MR
authors: Furtado
authors: Life Technologies, 1149 Chess Drive, Foster City, CA 94404, USA.
authors: Rixun
authors: R
authors: Fang
authors: Bioinformatics Research, National Marrow Donor Program, 3001 Broadway Street NE, Suite 100, Minneapolis, MN 55413, USA.
authors: Abeer
authors: A
authors: Madbouly
authors: Bioinformatics Research, National Marrow Donor Program, 3001 Broadway Street NE, Suite 100, Minneapolis, MN 55413, USA.
authors: Martin
authors: M
authors: Maiers
authors: Bioinformatics Research, National Marrow Donor Program, 3001 Broadway Street NE, Suite 100, Minneapolis, MN 55413, USA.
authors: Mridu
authors: M
authors: Middha
authors: 23 Hunting Ridge Road, Sharon, CT 06069, USA.
authors: Françoise R
authors: FR
authors: Friedlaender
authors: Department of Genetics, Yale University School of Medicine, New Haven, CT 06520-8005, USA.
authors: Judith R
authors: JR
authors: Kidd
mesh_terms: D053803:Forensic Genetics; D006801:Humans; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide
keywords: AIM; Ancestry; Population differentiation; SNP; Structure