title: Role of DNA sequence based structural features of promoters in transcription initiation and gene expression.
abstract: Regulatory information for transcription initiation is present in a stretch of genomic DNA, called the promoter region that is located upstream of the transcription start site (TSS) of the gene. The promoter region interacts with different transcription factors and RNA polymerase to initiate transcription and contains short stretches of transcription factor binding sites (TFBSs), as well as structurally unique elements. Recent experimental and computational analyses of promoter sequences show that they often have non-B-DNA structural motifs, as well as some conserved structural properties, such as stability, bendability, nucleosome positioning preference and curvature, across a class of organisms. Here, we briefly describe these structural features, the differences observed in various organisms and their possible role in regulation of gene expression.
authors: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India. Electronic address: mb@mbu.iisc.ernet.in.
authors: Manju
authors: M
authors: Bansal
authors: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
authors: Aditya
authors: A
authors: Kumar
authors: Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
authors: Venkata Rajesh
authors: VR
authors: Yella
mesh_terms: D000818:Animals; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D004247:DNA / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D006801:Humans; D059372:Nucleotide Motifs; D011401:Promoter Regions, Genetic / Q000235:genetics*; D024363:Transcription Initiation Site
chemical_list: D004247:DNA