title: The endocannabinoid system controls food intake via olfactory processes.
abstract: Hunger arouses sensory perception, eventually leading to an increase in food intake, but the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) receptors promote food intake in fasted mice by increasing odor detection. CB1 receptors were abundantly expressed on axon terminals of centrifugal cortical glutamatergic neurons that project to inhibitory granule cells of the main olfactory bulb (MOB). Local pharmacological and genetic manipulations revealed that endocannabinoids and exogenous cannabinoids increased odor detection and food intake in fasted mice by decreasing excitatory drive from olfactory cortex areas to the MOB. Consistently, cannabinoid agonists dampened in vivo optogenetically stimulated excitatory transmission in the same circuit. Our data indicate that cortical feedback projections to the MOB crucially regulate food intake via CB1 receptor signaling, linking the feeling of hunger to stronger odor processing. Thus, CB1 receptor-dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior.
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France. [3].
authors: Edgar
authors: E
authors: Soria-Gómez
authors: 1] Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University and CIBERNED, Madrid, Spain. [2].
authors: Luigi
authors: L
authors: Bellocchio
authors: Department of Neurosciences, Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU, Leioa, Spain.
authors: Leire
authors: L
authors: Reguero
authors: 1] Laboratory for Perception and Memory, Institut Pasteur, Paris, France. [2] CNRS UMR 3571, Paris, France.
authors: Gabriel
authors: G
authors: Lepousez
authors: CNRS UMR 8165, IMNC, Univ. Paris Diderot & Sud, Orsay, France.
authors: Claire
authors: C
authors: Martin
authors: CNRS UMR 8165, IMNC, Univ. Paris Diderot & Sud, Orsay, France.
authors: Mounir
authors: M
authors: Bendahmane
authors: Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
authors: Sabine
authors: S
authors: Ruehle
authors: Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
authors: Floor
authors: F
authors: Remmers
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France.
authors: Tifany
authors: T
authors: Desprez
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France.
authors: Isabelle
authors: I
authors: Matias
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France.
authors: Theresa
authors: T
authors: Wiesner
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France.
authors: Astrid
authors: A
authors: Cannich
authors: 1] Laboratory for Perception and Memory, Institut Pasteur, Paris, France. [2] CNRS UMR 3571, Paris, France.
authors: Antoine
authors: A
authors: Nissant
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France.
authors: Aya
authors: A
authors: Wadleigh
authors: Institut fuer Physiologie I, Westfaelische Wilhelms-Universitaet, Muenster, Germany.
authors: Hans-Christian
authors: HC
authors: Pape
authors: Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University and CIBERNED, Madrid, Spain.
authors: Anna Paola
authors: AP
authors: Chiarlone
authors: Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
authors: Carmelo
authors: C
authors: Quarta
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France.
authors: Daniéle
authors: D
authors: Verrier
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France.
authors: Peggy
authors: P
authors: Vincent
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France.
authors: Federico
authors: F
authors: Massa
authors: Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
authors: Beat
authors: B
authors: Lutz
authors: Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University and CIBERNED, Madrid, Spain.
authors: Manuel
authors: M
authors: Guzmán
authors: CNRS UMR 8165, IMNC, Univ. Paris Diderot & Sud, Orsay, France.
authors: Hirac
authors: H
authors: Gurden
authors: INRA, Nutrition et Neurobiologie Intégrée, UMR 1286, Bordeaux, France.
authors: Guillaume
authors: G
authors: Ferreira
authors: 1] Laboratory for Perception and Memory, Institut Pasteur, Paris, France. [2] CNRS UMR 3571, Paris, France.
authors: Pierre-Marie
authors: PM
authors: Lledo
authors: 1] Department of Neurosciences, Faculty of Medicine and Dentistry, University of the Basque Country UPV/EHU, Leioa, Spain. [2].
authors: Pedro
authors: P
authors: Grandes
authors: 1] INSERM, U862 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France. [2] University of Bordeaux, NeuroCentre Magendie U862, Bordeaux, France. [3].
authors: Giovanni
authors: G
authors: Marsicano
mesh_terms: D000818:Animals; D063386:Cannabinoid Receptor Agonists / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects / Q000502:physiology*; D063388:Endocannabinoids / Q000378:metabolism / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009830:Olfactory Bulb / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D009833:Olfactory Pathways / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D055696:Olfactory Perception / Q000187:drug effects / Q000502:physiology*; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*
chemical_list: C578453:CNR1 protein, mouse; D063386:Cannabinoid Receptor Agonists; D063388:Endocannabinoids; D043884:Receptor, Cannabinoid, CB1