title: Increased platelet distribution width is associated with ST-segment elevation myocardial infarction and thrombolysis failure.
abstract: We investigated 2 hypotheses: (1) a relationship between platelet indices and stable coronary artery disease (CAD) and acute ST-segment elevation myocardial infarction (STEMI) and (2) a relationship between platelet indices on admission and thrombolysis outcomes in patients with STEMI. A total of 260 patients were enrolled. The white blood cell (WBC) and platelet distribution width (PDW) were found to be increased in patients with STEMI (P for both < .001). White blood cell and PDW were independent predictors of acute STEMI. Mean platelet volume (MPV) and PDW were significantly higher in the thrombolysis failure group than in the thrombolysis success group (9.9 ± 1.8 vs 9.2 ± 1.5 fL, P = .021 and 17.7 ± 1.0 vs 16.4 ± 2.1 fL, P < .001, respectively). Mean platelet volume and PDW were independent predictors of thrombolysis failure. Patients with acute STEMI had higher PDW than did patients with stable CAD. In addition, higher PDW and MPV seem to correlate with thrombolysis failure in patients with STEMI.
authors: Department of Cardiology, School of Medicine, Adiyaman University, Adiyaman, Turkey drmcetin@gmail.com.
authors: Mustafa
authors: M
authors: Cetin
authors: Department of Cardiology, School of Medicine, Erzincan University, Erzincan, Turkey.
authors: Eftal Murat
authors: EM
authors: Bakirci
authors: Department of Cardiology, Diyarbakir Education and Research Hospital, Diyarbakir, Turkey.
authors: Erkan
authors: E
authors: Baysal
authors: Department of Cardiology, School of Medicine, Adiyaman University, Adiyaman, Turkey.
authors: Hakan
authors: H
authors: Tasolar
authors: Department of Cardiology, School of Medicine, Adiyaman University, Adiyaman, Turkey.
authors: Mehmet
authors: M
authors: Balli
authors: Department of Cardiology, School of Medicine, Adiyaman University, Adiyaman, Turkey.
authors: Musa
authors: M
authors: Cakici
authors: Department of Cardiology, School of Medicine, Adiyaman University, Adiyaman, Turkey.
authors: Sabri
authors: S
authors: Abus
authors: Department of Cardiology, School of Medicine, Adiyaman University, Adiyaman, Turkey.
authors: Erdal
authors: E
authors: Akturk
authors: Department of Cardiology, School of Medicine, Adiyaman University, Adiyaman, Turkey.
authors: Sami
authors: S
authors: Ozgul
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001792:Blood Platelets / Q000378:metabolism / Q000473:pathology*; D003324:Coronary Artery Disease / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000628:therapy*; D015539:Platelet Activation / Q000502:physiology; D015912:Thrombolytic Therapy
keywords: coronary artery disease; fibrinolysis; mean platelet volume; myocardial infarction; platelet distribution width; thrombolysis