title: Nanoemulsions in translational research-opportunities and challenges in targeted cancer therapy.
abstract: Nanoemulsion dosage form serves as a vehicle for the delivery of active pharmaceutical ingredients and has attracted great attention in drug delivery and pharmacotherapy. In particular, nanoemulsions act as an excellent vehicle for poorly aqueous soluble drugs, which are otherwise difficult to formulate in conventional dosage forms. Nanoemulsions are submicron emulsions composed of generally regarded as safe grade excipients. Particle size at the nanoscale and larger surface area lead to some very interesting physical properties that can be exploited to overcome anatomical and physiological barriers associated in drug delivery to the complex diseases such as cancer. Along these lines, nanoemulsions have been engineered with specific attributes such as size, surface charge, prolonged blood circulation, target specific binding ability, and imaging capability. These attributes can be tuned to assist in delivering drug/imaging agents to the specific site of interest, based on active and passive targeting mechanisms. This review focuses on the current state of nanoemulsions in the translational research and its role in targeted cancer therapy. In addition, the production, physico-chemical characterization, and regulatory aspects of nanoemulsion are addressed.
authors: Nemucore Medical Innovations, Inc., Worcester, Massachusetts, 01608, USA.
authors: Srinivas
authors: S
authors: Ganta
authors: Meghna
authors: M
authors: Talekar
authors: Amit
authors: A
authors: Singh
authors: Timothy P
authors: TP
authors: Coleman
authors: Mansoor M
authors: MM
authors: Amiji
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D003287:Contrast Media; D003952:Diagnostic Imaging / Q000379:methods; D004337:Drug Carriers; D004655:Emulsions; D006801:Humans; D008055:Lipids / Q000737:chemistry* / Q000633:toxicity; D058990:Molecular Targeted Therapy; D050997:Nanomedicine; D053758:Nanoparticles; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D019275:Radiopharmaceuticals; D013678:Technology, Pharmaceutical / Q000379:methods*; D057170:Translational Research, Biomedical; D059016:Tumor Microenvironment
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D004337:Drug Carriers; D004655:Emulsions; D008055:Lipids; D019275:Radiopharmaceuticals