title: Experimental oral immunization of ferret badgers (Melogale moschata) with a recombinant canine adenovirus vaccine CAV-2-E3Δ-RGP and an attenuated rabies virus SRV9.
abstract: Ferret badgers (Melogale moschata) are a major reservoir of rabies virus in southeastern China. Oral immunization has been shown to be a practical method for wildlife rabies management in Europe and North America. Two groups of 20 ferret badgers were given a single oral dose of a recombinant canine adenovirus-rabies vaccine, CAV-2-E3Δ-RGP, or an experimental attenuated rabies virus vaccine, SRV9. At 21 days, all ferret badgers had seroconverted, with serum virus-neutralizing antibodies ranging from 0.1 to 4.5 IU/mL. Titers were >0.50 IU/mL (an acceptable level) in 17/20 and 16/20 animals receiving CAV-2-E3Δ-RGP or SRV9, respectively. The serologic results indicate that the recombinant CAV-2-E3Δ-RGP is at least as effective as the attenuated rabies virus vaccine. Both may be considered for additional research as oral rabies vaccine candidates for ferret badgers.
authors: 1  Laboratory of Epidemiology, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Research Institute, Academy of Military Medical Sciences, 666 Liuying West Road, Changchun 130122, People's Republic of China.
authors: Jinghui
authors: J
authors: Zhao
authors: Ye
authors: Y
authors: Liu
authors: Shoufeng
authors: S
authors: Zhang
authors: Lijun
authors: L
authors: Fang
authors: Fei
authors: F
authors: Zhang
authors: Rongliang
authors: R
authors: Hu
mesh_terms: D000257:Adenoviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D006516:Adenoviruses, Canine / Q000276:immunology*; D000284:Administration, Oral; D000818:Animals; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D004197:Disease Reservoirs; D045969:Mustelidae; D011818:Rabies / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D011820:Rabies virus / Q000276:immunology*; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines