title: Cost-of-illness and quality of life in patients with ankylosing spondylitis at a tertiary hospital in Korea.
abstract: The objectives of this study were to estimate the cost-of-illness (COI) and health-related quality of life (HRQOL) in patients with ankylosing spondylitis (AS) in Korea and to evaluate the effects of socio-demographic and clinical factors on the COI and the HRQOL. Face-to-face interview surveys were taken from patients with AS at the Rheumatology Clinic of Seoul National University Hospital. Direct medical and non-medical costs, indirect costs (productivity loss due to job loss and sick leave), and deterioration of HRQOL in patients with AS were measured. Factors associated with COI and HRQOL were analyzed with multiple regression and multivariate logistic regression. A total of 191 patients with AS was enrolled in the study. The COI in patients with AS amounted to 11,646,180 Korean Won (KRW) per patient, and their HRQOL was 0.62. As functional severity worsened, the total costs increased (class I, KRW 7.7 million; class II, KRW 12.9 million; classes III & IV, KRW 25.2 million) and the HRQOL scores decreased (class I, 0.72; class II, 0.61; classes III & IV, 0.24). Functional severity is the major determinant of the COI and HRQOL in patients with AS.
authors.affiliation: Department of Health Policy and Management, Graduate School of Public Health & Institute of Health and Environment, Seoul National University, Seoul, Korea.
authors.forename: Tae-Jin
authors.identifier: 0000-0003-2539-3579
authors.initials: TJ
authors.lastname: Lee
authors.affiliation: Department of Nursing, Kimcheon Science College, Gimcheon, Korea.
authors.forename: Bo-Hyun
authors.identifier: 0000-0003-0315-2256
authors.initials: BH
authors.lastname: Park
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Joon Wan
authors.identifier: 0000-0002-7845-4382
authors.initials: JW
authors.lastname: Kim
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Kichul
authors.identifier: 0000-0002-6749-7598
authors.initials: K
authors.lastname: Shin
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Eun Bong
authors.identifier: 0000-0003-0703-1208
authors.initials: EB
authors.lastname: Lee
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Medical Research Center, Seoul National University College of Medicine, Seoul, Korea. ; WCU Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Yeong-Wook
authors.identifier: 0000-0002-5384-3437
authors.initials: YW
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D017281:Cost of Illness; D003365:Costs and Cost Analysis; D003710:Demography; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D056910:Republic of Korea; D012720:Severity of Illness Index; D013167:Spondylitis, Ankylosing / Q000188:drug therapy / Q000191:economics / Q000503:physiopathology*; D062606:Tertiary Care Centers
chemical_list: D000911:Antibodies, Monoclonal
keywords: Arthritis, Rheumatoid; Cost; Quality of Life; Spondylitis, Ankylosing