title: [Study of tolerance of central muscarinic receptor blockers].
abstract: The tolerance of five central muscarinic receptor antagonists has been studied in experimental animals. According to the effect on orientation-exploratory reaction, drugs were arranged in the following order of increasing toxicity: procyclidine < trihexiphenidyl < benactizine < atropine < scopolamine. For the same therapeutic index, trihexiphenidyl and benactizine were characterized by the maximum tolerance (TD50/ED50 > 10) in mice. Scopolamine and atropine exhibited anticonvulsant activity at doses exceeding the threshold values by a factor of 6.3 and 3.9, respectively. For procyclidine, the average anticonvulsant dose was threefold lower than the threshold value. Benactizine and procyclidine had maximum tolerance levels in rats. The TD50/ED50 ratio for these drugs was greater than 3 (against 0.5 - 0.7 in groups treated with trihexiphenidyl, atropine and scopolamine).
authors.forename: M A
authors.initials: MA
authors.lastname: Iudin
authors.forename: V N
authors.initials: VN
authors.lastname: Bykov
authors.forename: A S
authors.initials: AS
authors.lastname: Nikiforov
authors.forename: A F
authors.initials: AF
authors.lastname: Kupriakova
authors.forename: S N
authors.initials: SN
authors.lastname: Subbotina
authors.forename: I M
authors.initials: IM
authors.lastname: Ivanov
authors.forename: M A
authors.initials: MA
authors.lastname: Tiunin
authors.forename: I V
authors.initials: IV
authors.lastname: Fateev
authors.forename: N G
authors.initials: NG
authors.lastname: Vengerovich
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D008297:Male; D020714:Maximum Tolerated Dose; D051379:Mice; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D051381:Rats
chemical_list: D000927:Anticonvulsants; D018727:Muscarinic Antagonists