title: Barberry treatment reduces serum anti-heat shock protein 27 and 60 antibody titres and high-sensitivity c-reactive protein in patients with metabolic syndrome: a double-blind, randomized placebo-controlled trial.
abstract: Metabolic syndrome is an important risk factor for cardiovascular disease (CVD). The heat shock proteins (HSPs) are associated with risk factors for CVD. The aim of the present study was to survey the effect of barberry on antibody titres to HSPs and high-sensitivity C-reactive protein (hs-CRP) in patients with metabolic syndrome. In our study, subjects (N=106, 79 women and 27 men, 18-65 years old) with metabolic syndrome were randomized into two groups: a group of patients who received three capsules of barberry and a control group who received three capsules of placebo for 6 weeks. Antibodies against HSPs 27, 60/65 and 70, hs-CRP and lipid profile were determined in patients before (week 0) and after (week 6) intervention. spss software (version 16.0; Inc, Chicago, IL) was used for data analysis. Results showed that barberry had no significant effect on serum level of anti-HSPs 65 and 70. But there was a significant decrease in anti-HSP 27 in both case and control groups (p=0.001 and p<0.001, respectively, in the case and control groups). Barberry decreased significantly anti-HSP 60 in the case group (p=0.03). High-sensitivity CRP was decreased non-significantly (p=0.17) in the case group and increased significantly (p=0.04) in the control group. Barberry decreased significantly low-density lipoprotein and total cholesterol and increased significantly high-density cholesterol (p<0.05). Results of the present study suggested that barberry supplementation in patients with metabolic syndrome decreased significantly anti-HSPs 27 and 60 and hs-CRP levels and improved lipid profile.
authors.affiliation: Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
authors.forename: Marzie
authors.initials: M
authors.lastname: Zilaee
authors.forename: Tayyebeh
authors.initials: T
authors.lastname: Kermany
authors.forename: Shima
authors.initials: S
authors.lastname: Tavalaee
authors.forename: Maryam
authors.initials: M
authors.lastname: Salehi
authors.forename: Majid
authors.initials: M
authors.lastname: Ghayour-Mobarhan
authors.forename: Gordon A A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D028142:Berberis / Q000737:chemistry*; D002097:C-Reactive Protein / Q000378:metabolism*; D018834:Chaperonin 60 / Q000276:immunology; D002784:Cholesterol / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000276:immunology; D006360:Heat-Shock Proteins; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000276:immunology; D018832:Molecular Chaperones; D012307:Risk Factors
chemical_list: D000906:Antibodies; D018834:Chaperonin 60; D055551:HSP27 Heat-Shock Proteins; C057725:HSPB1 protein, human; C060293:HSPD1 protein, human; D006360:Heat-Shock Proteins; D008077:Lipoproteins, LDL; D024101:Mitochondrial Proteins; D018832:Molecular Chaperones; D002097:C-Reactive Protein; D002784:Cholesterol
keywords: anti-heat shock proteins; barberry; metabolic syndrome