title: A novel karyotype in acute myeloid leukemia with basophilia.
abstract: Acute basophilic leukemia is a distinct entity of Acute Myeloid Leukemia (AML) with primary differentiation to basophils. Increased basophil count has been described in AML cases with translocation t(6;9)(p23;q34) or other chromosomal abnormalities. We describe a 15-year old female teenager with AML and excess peripheral blood and bone marrow basophils. Her white blood cell count at diagnosis was 15.4 G/L with 53% basophils and 17% blasts. The bone marrow cytogenetics analysis did not reveal any of the usual abnormalities. The karyotype showed two closely related leukemic clones: the first (16 metaphases), with a total of 48 chromosomes, had an extra chromosome 8 with deletion of the long arm and an additional 21 (48,XX, +del(8)(q24.2q24.3), t21[16]), while the second clone (2 metaphases), with a total of 47 chromosomes, did not contain the extra 21 chromosome (47, sl, -21[2]). In summary, in this case of AML-M2 with excess basophils, there is a novel chromosomal abnormality, not previously reported in this entity.
authors.affiliation: Oncology Department, Children's Hospital "P. & A. Kyriakou", Thivon and Levadias, Athens, Greece.
authors.forename: Marina
authors.initials: M
authors.lastname: Servitzoglou
authors.forename: Maria
authors.initials: M
authors.lastname: Grenzelia
authors.forename: Margarita
authors.initials: M
authors.lastname: Baka
authors.forename: Marietta
authors.initials: M
authors.lastname: Harisi
authors.forename: Apostolos
authors.initials: A
authors.lastname: Pourtsidis
authors.forename: Despina
authors.initials: D
authors.lastname: Bouhoutsou
authors.forename: Maria
authors.initials: M
authors.lastname: Varvoutsi
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Doganis
authors.forename: Helen
authors.initials: H
authors.lastname: Dana
authors.forename: Aspasia
authors.initials: A
authors.lastname: Divane
authors.forename: Helen
authors.initials: H
authors.lastname: Kosmidis
mesh_terms: D000293:Adolescent; D001491:Basophils / Q000473:pathology*; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D059785:Karyotype; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology