title: Boldine and related aporphines: from antioxidant to antiproliferative properties.
abstract: Plant and folk medicine represent nowadays a source of either new therapeutic substances or substrates for drug synthesis. One such promising group for possible further exploitation is the family of aporphine alkaloids containing boldine and related compounds. In this mini-review we focus on boldine and its newly described effects, which predominantly arise from its antioxidant properties. Moreover, we try to compare its antiproliferative properties with other better known members of the aporphine group.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, Hradec Kralove 500 38, Czech Republic. muthnad@Ifhk.cuni.cz
authors.forename: Darina
authors.initials: D
authors.lastname: Muthna
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, Hradec Kralove 500 38, Czech Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Cmielova
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, Hradec Kralove 500 38, Czech Republic.
authors.forename: Pavel
authors.initials: P
authors.lastname: Tomsik
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Simkova 870, Hradec Kralove 500 38, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Rezacova
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001060:Aporphines / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001060:Aporphines; C011686:boldine