title: Hepatoprotective effects of triterpenoids from Ganoderma cochlear.
abstract: Two novel trinorlanostanes, cochlates A and B (1 and 2), with a 3,4-seco-9,10-seco-9,19-cyclo skeleton, as well as six new triterpenoids, fornicatins D-F (3-5) and ganodercochlearins A-C (6-8), together with five known triterpenoids (9-13), were obtained from the fruiting bodies of Ganoderma cochlear. The structural elucidation was achieved by interpretation of spectroscopic data, and compounds 2 and 7a were further characterized by X-ray crystallographic analysis. Fornicatins A, D, and F (10, 3, and 5) and fredelin (13) lowered the ALT and AST levels in HepG2 cells treated with H2O2, suggesting that they could display in vivo hepatoprotective activities.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science , Kunming 650201, People's Republic of China.
authors.forename: Xing-Rong
authors.initials: XR
authors.lastname: Peng
authors.forename: Jie-Qing
authors.initials: JQ
authors.lastname: Liu
authors.forename: Cui-Fang
authors.initials: CF
authors.lastname: Wang
authors.forename: Xu-Yang
authors.initials: XY
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Shu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Qiu
mesh_terms: D000465:Algorithms; D002681:China; D018360:Crystallography, X-Ray; D032902:Ganoderma / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D014315:Triterpenes; C000589419:cochlate A; C000589420:cochlate B; D007810:Lanosterol; D006861:Hydrogen Peroxide