title: [Clinical significance for monitoring of serum ghrelin in acute pancreatitis severity assessment].
abstract: OBJECTIVE
  To explore the value of altered serum level of Ghrelin for severity assessment in patients with acute pancreatitis (AP).
  
  
  METHODS
  Peripheral blood samples were collected from 47 AP patients at admission, 48 hours post-admission and at discharge. According to the criteria of APACHEII score ≥ 8, RANSON ≥ 3, CT ≥ 4, they were divided into mild (n = 17) and severe (n = 30) groups. Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum level of Ghrelin. And correlation analysis was made with the score of APACHEII and the level of C reactive protein (CRP). Also the serum level of Ghrelin was analyzed with receiver operating characteristic (ROC) curve.
  
  
  RESULTS
  The serum levels of Ghrelin after 24 h were 358.6 ± 119.3 vs 212.1 ± 42.7 ng/L (P < 0.001); after 48 hours, 253.1 ± 71.2 vs 275.5 ± 73.6 ng/L (P = 0.572); at discharge, 327.8 ± 103.8 vs 319.4 ± 87.1 ng/L respectively (P = 0.816). And serum level of Ghrelin was positively correlated with APACHEII and CRP. ROC area under curve was 0.841 ± 0.057 and 95% confidence interval 0.729-0.952 (P < 0.001).
  
  
  CONCLUSIONS
  The serum level of Ghrelin during early-stage AP has significant differences between two groups. And it may become an early predictor of pancreatic necrosis and a degree marker of clinical severity.
authors.affiliation: Department of Hepatic Surgery, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.affiliation: Department of Hepatic Surgery, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Hepatic Surgery, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Jian-tao
authors.initials: JT
authors.lastname: Kou
authors.affiliation: Department of Hepatic Surgery, Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
authors.forename: Li-xin
authors.initials: LX
authors.lastname: Li
authors.affiliation: Department of Hepatic Surgery, Chaoyang Hospital, Capital Medical University, Beijing 100020, China. Email: heqiang349@sina.com.
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
mesh_terms: D018806:APACHE; D000208:Acute Disease; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood*; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D054439:Ghrelin