title: Manganese(III)-mediated direct Csp2-H radical trifluoromethylation of coumarins with sodium trifluoromethanesulfinate.
abstract: Mn(OAc)3-mediated direct Csp2-H radical trifluoromethylation of coumarins with CF3SO2Na (Langlois reagent) to afford selective 3-trifluoromethyl coumarins in moderate to good yields is described. This methodology can also be applied to the trifluoromethylation of quinolinones and pyrimidinones.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Soochow University, 199 Renai Street, Suzhou, Jiangsu 215123, China. jpzou@suda.edu.cn.
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Cao
authors.forename: Xiangqiang
authors.initials: X
authors.lastname: Pan
authors.forename: Peng-Jun
authors.initials: PJ
authors.lastname: Zhou
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Zou
authors.forename: Olayinka Taiwo
authors.initials: OT
authors.lastname: Asekun
mesh_terms: D003374:Coumarins / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*
chemical_list: D003374:Coumarins; D006845:Hydrocarbons, Fluorinated; D008698:Mesylates; C000592252:sodium trifluoromethanesulfinate; D008345:Manganese