title: Evaluation of Neural Response Telemetry (NRT™) with focus on long-term rate adaptation over a wide range of stimulation rates.
abstract: Custom Sound EP™ (CSEP) is an advanced flexible software tool dedicated to recording of electrically evoked compound action potentials (ECAPs) in Nucleus® recipients using Neural Response Telemetry™ (NRT™). European multi-centre studies of the Freedom™ cochlear implant system confirmed that CSEP offers tools to effectively record ECAP thresholds, amplitude growth functions, recovery functions, spread of excitation functions, and rate adaptation functions and an automated algorithm (AutoNRT™) to measure threshold profiles. This paper reports on rate adaptation measurements. Rate adaptation of ECAP amplitudes can successfully be measured up to rates of 495 pulses per second (pps) by repeating conventional ECAP measurements and over a wide range of rates up to 8000 pps using the masked response extraction technique. Rate adaptation did not show a predictable relationship with speech perception and coding strategy channel rate preference. The masked response extraction method offers opportunities to study long-term rate adaptation with well-defined and controlled stimulation paradigms.
authors.forename: Alicia
authors.initials: A
authors.lastname: Huarte
authors.forename: Angel
authors.initials: A
authors.lastname: Ramos
authors.forename: Constantino
authors.initials: C
authors.lastname: Morera
authors.forename: Luis
authors.initials: L
authors.lastname: Garcia-Ibáñez
authors.forename: Rolf
authors.initials: R
authors.lastname: Battmer
authors.forename: Norbert
authors.initials: N
authors.lastname: Dillier
authors.forename: Thomas
authors.initials: T
authors.lastname: Wesarg
authors.forename: Joachim
authors.initials: J
authors.lastname: Müller-Deile
authors.forename: Mattias
authors.initials: M
authors.lastname: Hey
authors.forename: Erwin
authors.initials: E
authors.lastname: Offeciers
authors.forename: Ernst
authors.initials: E
authors.lastname: von Wallenberg
authors.forename: Chrystelle
authors.initials: C
authors.lastname: Coudert
authors.forename: Matthijs
authors.initials: M
authors.lastname: Killian
mesh_terms: D000328:Adult; D001306:Auditory Pathways / Q000502:physiology; D001309:Auditory Threshold / Q000502:physiology; D003054:Cochlear Implants; D016057:Evoked Potentials, Auditory, Brain Stem; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology / Q000534:rehabilitation*; D006801:Humans; D008144:Loudness Perception; D009434:Neural Pathways / Q000502:physiology*; D013686:Telemetry / Q000295:instrumentation*
keywords: Adaptation; Cochlear Implant; Electrophysiology; NRT