title: Endoplasmic reticulum stress in cerebral ischemia.
abstract: The endoplasmic reticulum (ER) stress is an essential step in the progression of brain ischemia/reperfusion (I/R) injury. It is possible that the timing of events for ER stress signaling regulation is important for the balance of life and death such that ER stress is initially protective, aiming to restore ER homeostasis, whereas prolonged periods of ER stress can be deleterious and damaging. Nevertheless, modulation of ER stress exerts a remarkable protective effect on the ischemic brain and offers the prospect of new stroke therapies. As ER stress is not devoid of deleterious side effects, a better understanding of the reciprocal interaction between the ER and the ischemic brain is essential to harness the full therapeutic potential of ischemic stroke.
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining 272067, China; Department of Neurobiology, Xinxiang Medical University, Xinxiang 453003, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Xin
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining 272067, China.
authors.forename: Bingyuan
authors.initials: B
authors.lastname: Ji
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining 272067, China.
authors.forename: Baohua
authors.initials: B
authors.lastname: Cheng
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining 272067, China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Wang
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining 272067, China.
authors.forename: Haiqing
authors.initials: H
authors.lastname: Liu
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining 272067, China.
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Chen
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining 272067, China. Electronic address: jingchen@mail.jnmc.edu.cn.
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.affiliation: Neurobiology Institute, Jining Medical University, Jining 272067, China. Electronic address: bbai@mail.jnmc.edu.cn.
authors.forename: Bo
authors.initials: B
authors.lastname: Bai
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D002544:Cerebral Infarction / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress / Q000502:physiology*; D006801:Humans; D015427:Reperfusion Injury / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
keywords: Endoplasmic reticulum stress; Neuroprotection; Stroke