title: Phaseolamin treatment prevents oxidative stress and collagen deposition in the hearts of streptozotocin-induced diabetic rats.
abstract: The development of cardiovascular complications in patients with diabetes is often associated with an imbalance between reactive oxygen species and antioxidant systems. This imbalance can contribute to high cardiac collagen content, which increases cross-linking and the stiffness of the myocardium. In this study, the protective effect of phaseolamin against damage under oxidative stress and collagen deposition in the cardiac tissue in association with diabetes was evaluated. Non-diabetic and diabetic animals were distributed into groups and treated for 20 days with commercial phaseolamin. The phaseolamin treatment increased total antioxidant activity but reduced the following in diabetic rats: (a) hyperglycaemic state, (b) catalase and superoxide dismutase activity and (c) tissue damage caused by lipid peroxidation. Additionally, the phaseolamin treatment attenuated the collagen levels compared to non-treated diabetic rats. Thus, the short-term anti-hyperglycaemic effect of the phaseolamin treatment may prevent the initial changes caused by oxidative stress and the deposition of collagen, as well as reduce the incidence of heart complications.
authors.affiliation: Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Brazil.
authors.forename: Renato J S
authors.initials: RJ
authors.lastname: Oliveira
authors.forename: Vanessa N
authors.initials: VN
authors.lastname: de Oliveira
authors.forename: Simone R
authors.initials: SR
authors.lastname: Deconte
authors.forename: Luciana K
authors.initials: LK
authors.lastname: Calábria
authors.forename: Alberto
authors.initials: A
authors.lastname: da Silva Moraes
authors.forename: Foued S
authors.initials: FS
authors.lastname: Espindola
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced; D004195:Disease Models, Animal; D006321:Heart / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D037121:Plant Lectins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D037121:Plant Lectins; C061510:alpha-amylase inhibitor, Phaseolus vulgaris; D013311:Streptozocin; D003094:Collagen
keywords: Diabetes; alpha-amylase inhibitor; collagen; oxidative stress; phaseolamin