title: The association of early life supplemental nutrition with lean body mass and grip strength in adulthood: evidence from APCAPS.
abstract: In the present study, we examined the associations of early nutrition with adult lean body mass (LBM) and muscle strength in a birth cohort that was established to assess the long-term impact of a nutrition program. Participants (n = 1,446, 32% female) were born near Hyderabad, India, in 29 villages from 1987 to 1990, during which time only intervention villages (n = 15) had a government program that offered balanced protein-calorie supplementation to pregnant women and children. Participants' LBM and appendicular skeletal muscle mass were measured using dual energy x-ray absorptiometry; grip strength and information on lifestyle indicators, including diet and physical activity level, were also obtained. Ages (mean = 20.3 years) and body mass indexes (weight (kg)/height (m)(2); mean = 19.5) of participants in 2 groups were similar. Current dietary energy intake was higher in the intervention group. Unadjusted LBM and grip strength were similar in 2 groups. After adjustment for potential confounders, the intervention group had lower LBM (β = -0.75; P = 0.03), appendicular skeletal muscle mass, and grip strength than did controls, but these differences were small in magnitude (<0.1 standard deviation). Multivariable regression analyses showed that current socioeconomic position, energy intake, and physical activity level had a positive association with adult LBM and muscle strength. This study could not detect a "programming" effect of early nutrition supplementation on adult LBM and muscle strength.
authors.forename: Bharati
authors.initials: B
authors.lastname: Kulkarni
authors.forename: Hannah
authors.initials: H
authors.lastname: Kuper
authors.forename: K V
authors.initials: KV
authors.lastname: Radhakrishna
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Hills
authors.forename: Nuala M
authors.initials: NM
authors.lastname: Byrne
authors.forename: Amy
authors.initials: A
authors.lastname: Taylor
authors.forename: Ruth
authors.initials: R
authors.lastname: Sullivan
authors.forename: Liza
authors.initials: L
authors.lastname: Bowen
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Wells
authors.forename: Yoav
authors.initials: Y
authors.lastname: Ben-Shlomo
authors.forename: George
authors.initials: G
authors.lastname: Davey Smith
authors.forename: Shah
authors.initials: S
authors.lastname: Ebrahim
authors.forename: Sanjay
authors.initials: S
authors.lastname: Kinra
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D001823:Body Composition; D015992:Body Mass Index; D002664:Child Nutritional Physiological Phenomena; D002675:Child, Preschool; D004032:Diet; D019587:Dietary Supplements / Q000706:statistics & numerical data*; D002149:Energy Intake / Q000502:physiology*; D015444:Exercise; D005260:Female; D018737:Hand Strength / Q000502:physiology*; D015438:Health Behavior; D006801:Humans; D007194:India; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D053580:Muscle Strength; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D012959:Socioeconomic Factors
keywords: body composition; cohort study; developmental origins of health and disease; grip strength; lean body mass; muscle mass; nutrition; physical activity