title: Oocyte retrieval timing based on spontaneous luteinizing hormone surge during natural cycle in vitro fertilization treatment.
abstract: OBJECTIVE
  To determine the efficiency of oocyte retrieval (OR) timing based on the occurrence of spontaneous LH surge during natural cycle IVF (ncIVF) treatment.
  
  
  METHODS
  Retrospective cohort study. The cohort was divided into five subgroups according to the presumed stage of spontaneous LH surge on scheduling day (1A: before onset; 1B: surge start; 2: ascending slope; 3: peak; and 4: descending slope).
  
  
  METHODS
  Private infertility clinic.
  
  
  METHODS
  Three hundred sixty-five infertile patients who underwent 1,138 ncIVF treatment cycles during 2008-2011.
  
  
  METHODS
  Drug-free ncIVF treatment.
  
  
  METHODS
  Rate of successfully retrieved, fertilized oocytes, cleaved embryos, and live births per scheduled oocyte retrieval.
  
  
  RESULTS
  In 61% of the cycles OR was scheduled before or just at the start of the LH surge (groups 1A-1B), whereas in the remaining cases it was scheduled after the surge had already started (groups 2-4). The proportion of cycles with successfully recovered (range, 71%-86%), inseminated (range, 61%-78%), fertilized oocytes (range, 47%-68%), cleaved embryos (range, 45%-66%), and live births (range, 4.1%-9.2%) was not significantly different among subgroups.
  
  
  CONCLUSIONS
  In ncIVF treatment OR timing based on the occurrence of spontaneous LH surge is feasible, yielding acceptable oocyte recovery, fertilization, and embryo cleavage rates. This strategy combined with a rapid and low-risk OR procedure permits the management of a large ncIVF program on a 7-days-per-week basis within working hours.
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan. Electronic address: bodridaniel@gmail.com.
authors.forename: Daniel
authors.initials: D
authors.lastname: Bodri
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kawachiya
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan.
authors.forename: Masae
authors.initials: M
authors.lastname: Kondo
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan.
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kato
authors.affiliation: Kobe Motomachi Yume Clinic, Kobe, Japan.
authors.forename: Tsunekazu
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D017677:Age Distribution; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D007247:Infertility, Female / Q000097:blood* / Q000453:epidemiology / Q000628:therapy*; D007564:Japan / Q000453:epidemiology; D007986:Luteinizing Hormone / Q000097:blood*; D008597:Menstrual Cycle / Q000097:blood*; D054315:Oocyte Retrieval / Q000379:methods / Q000706:statistics & numerical data*; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007986:Luteinizing Hormone
keywords: GnRH agonist triggering; LH surge; Natural cycle IVF; in vitro fertilization