title: Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies.
abstract: Biomimetic nanoparticles prepared by self-assembly of iminosugar-based glycopolypeptides evidenced remarkable multivalency properties when inhibiting α-mannosidase activity. This approach paves the way to obtain biologically active drug delivery systems having glycosidase inhibition potency.
authors.affiliation: Université de Bordeaux/IPB, ENSCBP, 16 avenue Pey Berland, 33607 Pessac Cedex, France. lecommandoux@enscbp.fr.
authors.forename: Colin
authors.initials: C
authors.lastname: Bonduelle
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Teresa
authors.initials: T
authors.lastname: Mena-Barragán
authors.forename: Carmen
authors.initials: C
authors.lastname: Ortiz Mellet
authors.forename: Camille
authors.initials: C
authors.lastname: Decroocq
authors.forename: Emile
authors.initials: E
authors.lastname: Etamé
authors.forename: Andreas
authors.initials: A
authors.lastname: Heise
authors.forename: Philippe
authors.initials: P
authors.lastname: Compain
authors.forename: Sebastien
authors.initials: S
authors.lastname: Lecommandoux
mesh_terms: D017485:1-Deoxynojirimycin / Q000031:analogs & derivatives / Q000737:chemistry*; D016503:Drug Delivery Systems; D006020:Glycopeptides / Q000737:chemistry*; D006023:Glycoproteins / Q000737:chemistry; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D008024:Ligands; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*
chemical_list: D006020:Glycopeptides; D006023:Glycoproteins; D008024:Ligands; D008823:Micelles; D010455:Peptides; D017485:1-Deoxynojirimycin; D006026:Glycoside Hydrolases