title: Particle replication in nonwetting templates nanoparticles with tumor selective alkyl silyl ether docetaxel prodrug reduces toxicity.
abstract: Delivery systems designed to have triggered release after passively targeting the tumor may improve small molecule chemotherapeutic delivery. Particle replication in nonwetting templates was used to prepare nanoparticles to passively target solid tumors in an A549 subcutaneous xenograft model. An acid labile prodrug was delivered to minimize systemic free docetaxel concentrations and improve tolerability without compromising efficacy.
authors.affiliation: Department of Pharmaceutical Sciences, ‡Department of Chemistry, §Lineberger Comprehensive Cancer Center, ∥Department of Biochemistry and Biophysics, ⊥Institute for Pharmacogenomics and Individualized Therapy, ¶Carolina Center of Cancer Nanotechnology Excellence, □Department of Pharmacology, Eshelman School of Pharmacy, ■Institute for Nanomedicine, ○Institute for Advanced Materials, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Chu
authors.forename: Mathew C
authors.initials: MC
authors.lastname: Finniss
authors.forename: Allison N
authors.initials: AN
authors.lastname: Schorzman
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Kuijer
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Luft
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Bowerman
authors.forename: Mary E
authors.initials: ME
authors.lastname: Napier
authors.forename: Zishan A
authors.initials: ZA
authors.lastname: Haroon
authors.forename: William C
authors.initials: WC
authors.lastname: Zamboni
authors.forename: Joseph M
authors.initials: JM
authors.lastname: DeSimone
mesh_terms: D000818:Animals; D000077143:Docetaxel; D004337:Drug Carriers / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology; D043823:Taxoids / Q000737:chemistry / Q000494:pharmacology; D017155:Wettability; D023041:Xenograft Model Antitumor Assays
chemical_list: D004337:Drug Carriers; D011355:Prodrugs; D043823:Taxoids; D000077143:Docetaxel