title: Butremycin, the 3-hydroxyl derivative of ikarugamycin and a protonated aromatic tautomer of 5'-methylthioinosine from a Ghanaian Micromonospora sp. K310.
abstract: A new actinomycete strain Micromonospora sp. K310 was isolated from Ghanaian mangrove river sediment. Spectroscopy-guided fractionation led to the isolation of two new compounds from the fermentation culture. One of the compounds is butremycin (2) which is the (3-hydroxyl) derivative of the known Streptomyces metabolite ikarugamycin (1) and the other compound is a protonated aromatic tautomer of 5'-methylthioinosine (MTI) (3). Both new compounds were characterized by 1D, 2D NMR and MS data. Butremycin (2) displayed weak antibacterial activity against Gram-positive S. aureus ATCC 25923, the Gram-negative E. coli ATCC 25922 and a panel of clinical isolates of methicillin-resistant S. aureus (MRSA) strains while 3 did not show any antibacterial activity against these microbes.
authors.affiliation: Marine and Plant Laboratory of Ghana, Department of Chemistry, University of Ghana, Accra, P.O. Box LG 56, Ghana. kkyeremeh@ug.edu.gh.
authors.forename: Kwaku
authors.initials: K
authors.lastname: Kyeremeh
authors.affiliation: Marine and Plant Laboratory of Ghana, Department of Chemistry, University of Ghana, Accra, P.O. Box LG 56, Ghana. ksaquah@yahoo.com.
authors.forename: Kojo Sekyi
authors.initials: KS
authors.lastname: Acquah
authors.affiliation: Department of Biology, Faculty of Art and Science, Ondokuz Mayis University, Kurupelit Samsun 55139, Turkey. asazak@omu.edu.tr.
authors.forename: Anil
authors.initials: A
authors.lastname: Sazak
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, Scotland, UK. w.houssen@abdn.ac.uk.
authors.forename: Wael
authors.initials: W
authors.lastname: Houssen
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, Scotland, UK. j.tabudravu@abdn.ac.uk.
authors.forename: Jioji
authors.initials: J
authors.lastname: Tabudravu
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, Scotland, UK. h.deng@abdn.ac.uk.
authors.forename: Hai
authors.initials: H
authors.lastname: Deng
authors.affiliation: Marine Biodiscovery Centre, Department of Chemistry, University of Aberdeen, Old Aberdeen AB24 3UE, Scotland, UK. m.jaspars@abdn.ac.uk.
authors.forename: Marcel
authors.initials: M
authors.lastname: Jaspars
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology; D005869:Ghana; D047029:Lactams, Macrocyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008778:Methylthioinosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000737:chemistry*; D045483:Rivers / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D047029:Lactams, Macrocyclic; C000591703:butremycin; C038025:5'-methylthioinosine; D008778:Methylthioinosine