title: Organization of the mouse and human DC network.
abstract: Dendritic cells (DCs) are the most potent antigen sensing and presenting cells in the body and are able to both initiate and fine-tune complex immune responses on a multitude of levels. In this review, we outline recent advances in our understanding of the organization of the DC network in mice and humans, the functional specialization of the DC subsets that compose these networks, and how this has enabled us to begin to elucidate cross-species parallels. Understanding the inter-relationships between DC populations in both man and mouse will ultimately allow us to exploit our knowledge of DC biology for effective therapeutic strategies.
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 138648 Singapore.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schlitzer
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), 138648 Singapore. Electronic address: Florent_ginhoux@immunol.a-star.edu.sg.
authors.forename: Florent
authors.initials: F
authors.lastname: Ginhoux
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis; D018949:Antigens, CD1 / Q000096:biosynthesis; D000954:Antigens, Surface / Q000096:biosynthesis; D039481:CD11b Antigen / Q000096:biosynthesis; D016827:CD8 Antigens / Q000096:biosynthesis; D016764:Cell Polarity / Q000276:immunology; D045142:Cross-Priming / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D006023:Glycoproteins / Q000096:biosynthesis; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D039001:Integrin alpha Chains / Q000096:biosynthesis; D051379:Mice; D058504:Th17 Cells / Q000276:immunology; D018180:Thrombomodulin
chemical_list: D015703:Antigens, CD; D018949:Antigens, CD1; D000954:Antigens, Surface; D039481:CD11b Antigen; C437944:CD1C protein, human; D016827:CD8 Antigens; C431698:CD8alpha antigen; D006023:Glycoproteins; D039001:Integrin alpha Chains; C546931:THBD protein, human; D018180:Thrombomodulin; C091367:alpha E integrins