title: Association of genetic variants in GNβ3 with functional dyspepsia: a meta-analysis.
abstract: BACKGROUND
  Functional dyspepsia (FD) is a functional upper gastrointestinal disorder. The etiology and pathogenesis of FD remain unclear, with genetic factors playing an important role. Previous studies investigated the association of C825T in GNβ3 with FD, with conflicting results reported.
  
  
  OBJECTIVE
  The aim of this meta-analysis is to assess the association of genetic variants in GNβ3 with FD.
  
  
  METHODS
  We performed a systematic literature search in PubMed, Cochrane Library, Google Scholar, and Web of Knowledge, and conducted a meta-analysis to assess the association of C825T in GNβ3 with FD. For sensitivity analysis, we analyzed the association between C825T and subtypes of FD. We also performed meta-analyses separately for individual ethnic groups/countries of origin.
  
  
  RESULTS
  A total of eight studies met the eligibility criteria and were included in our analyses. Our meta-analysis finds no association between 825CC and FD (OR 1.19, 95% CI 0.84-1.67, p = 0.328). However, the association is significant under an additive model (OR 0.59, 95% CI 0.38-0.92, p = 0.018). Sensitivity analysis indicated a significant association of C825T with FD in participants from Korea but not in those from Japan, Europe, or the United States. We also detected a significant association of this SNP with dysmotility.
  
  
  CONCLUSIONS
  The genetic variant C825T in GNβ3 is significantly associated with FD under an additive model and the association is race-specific. Further studies with larger samples sizes are needed to validate our findings and to explore the potential mechanism underlying the association.
authors.affiliation: Division of Gastroenterology, Second Affiliated Hospital, Medical College of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Dai
authors.forename: Yaping
authors.initials: Y
authors.lastname: Liu
authors.forename: Haitao
authors.initials: H
authors.lastname: Shi
authors.forename: Shuqiong
authors.initials: S
authors.lastname: Ge
authors.forename: Jun
authors.initials: J
authors.lastname: Song
authors.forename: Lei
authors.initials: L
authors.lastname: Dong
authors.forename: Jingyun
authors.initials: J
authors.lastname: Yang
mesh_terms: D004415:Dyspepsia / Q000235:genetics*; D056726:Genetic Association Studies; D014644:Genetic Variation / Q000235:genetics; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D021122:Protein Subunits / Q000235:genetics
chemical_list: C454420:G-protein beta3 subunit; D021122:Protein Subunits; D020962:Heterotrimeric GTP-Binding Proteins