title: Extensive serum biomarker analysis in patients with enterohemorrhagic Escherichia coli O111-induced hemolytic-uremic syndrome.
abstract: Proinflammatory cytokines are related to the pathogenesis of enterohemorrhagic Escherichia coli infection and hemolytic-uremic syndrome (HUS). We employed an antibody array that simultaneously detects 174 serum cytokines. We identified five serum biomarkers, namely insulin growth factor-binding protein-2, angiopoietin-2, soluble interleukin-6 receptor, soluble tumor necrosis factor receptor type II, and matrix metalloprotease protein-3 whose levels increased with the development of HUS. Furthermore, the levels of these cytokines were significantly increased in severe HUS compared with mild HUS. These cytokines might play an important role in the pathogenesis of HUS and may also be used to predict the severity of HUS.
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan. Electronic address: shimizum@staff.kanazawa-u.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Shimizu
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
authors.forename: Mondo
authors.initials: M
authors.lastname: Kuroda
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
authors.forename: Natsumi
authors.initials: N
authors.lastname: Inoue
authors.affiliation: Department of Pediatrics, Tonami General Hospital, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Konishi
authors.affiliation: Department of Pediatrics, Toyama Prefectural Central Hospital, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Igarashi
authors.affiliation: Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Taneichi
authors.affiliation: Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kanegane
authors.affiliation: Department of Obstetrics and Gynaecology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Ito
authors.affiliation: Department of Obstetrics and Gynaecology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
authors.affiliation: Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yachie
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002648:Child; D016207:Cytokines / Q000097:blood; D054324:Enterohemorrhagic Escherichia coli / Q000502:physiology*; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000097:blood* / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D008297:Male; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D016207:Cytokines
keywords: Biomarker; Cytokine; Enterohemorrhagic; Escherichia coli; Hemolytic-uremic syndrome