title: Pulmonary-Renal Syndrome with Negative ANCAs and Anti-GBM Antibody.
abstract: We report the case of a 76-year-old woman who was referred to our hospital for a gradually worsening cough and renal dysfunction. Although pneumonia was initially suspected, imaging findings of the lungs revealed diffuse alveolar hemorrhage at a later date. Renal failure developed and hemodiafiltration was performed on the 9th day. Rapidly progressive glomerulonephritis with crescent formation was diagnosed by renal biopsy. This case presentation has important clinical implications because uncategorizable pulmonary-renal syndrome (PRS) without the presence of ANCAs and anti-GBM antibody is extremely rare and has high rates of morbidity and mortality. No treatment has been established.
authors.affiliation: Department of Diabetology and Metabolic Medicine, Tokushima Prefectural Central Hospital, 1-10-3, Kuramoto, Tokushima 770-8539, Japan ; Department of Internal Medicine, Tokushima Prefectural Central Hospital, 1-10-3, Kuramoto, Tokushima 770-8539, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamaguchi
authors.affiliation: Department of Diabetology and Metabolic Medicine, Tokushima Prefectural Central Hospital, 1-10-3, Kuramoto, Tokushima 770-8539, Japan.
authors.forename: Atsuhisa
authors.initials: A
authors.lastname: Shirakami
authors.affiliation: Department of Respiratory Medicine, Tokushima Prefectural Central Hospital, 1-10-3, Kuramoto, Tokushima 770-8539, Japan.
authors.forename: Takashi
authors.identifier: 0000-0002-4181-0566
authors.initials: T
authors.lastname: Haku
authors.affiliation: Department of Respiratory Medicine, Tokushima Prefectural Central Hospital, 1-10-3, Kuramoto, Tokushima 770-8539, Japan.
authors.forename: Takashige
authors.initials: T
authors.lastname: Taoka
authors.affiliation: Department of Urology, Tokushima Prefectural Central Hospital, 1-10-3, Kuramoto, Tokushima 770-8539, Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakanishi
authors.affiliation: Department of Urology, Tokushima Prefectural Central Hospital, 1-10-3, Kuramoto, Tokushima 770-8539, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Inai
authors.affiliation: Department of Diagnostic Pathology, Tokushima Prefectural Central Hospital, 1-10-3, Kuramoto, Tokushima 770-8539, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Hirose