title: Atherosclerosis burden in patients with acute chest pain: obesity paradox.
abstract: Obesity paradox has been described in various populations of coronary artery disease, mainly asymptomatic subjects. However, relationship between obesity and coronary artery calcification detected by cardiac CT in symptomatic patients has rarely been demonstrated. This study seeks to investigate whether the paradoxical relationship between obesity and coronary artery calcification exists in patients with acute chest pain. A final cohort of 1030 chest pain patients presenting at our emergency department who underwent coronary evaluation by multidetector cardiac CT were examined. With absent-to-mild coronary calcification (CAC score < 100) as a referent, multivariable analysis showed that presence of obesity (OR 0.564; 95% CI 0.395, 0.806; P 0.002), body mass index (OR 0.945; 95% CI 0.920, 0.971; P < 0.001), body weight (OR 0.987; 95% CI 0.979, 0.995; P 0.001), and body surface area (OR 0.582; 95% CI 0.369, 0.920; P 0.020) were inversely associated with moderate-to-severe coronary calcification (CAC score ≥ 100). This study extends the concept of obesity paradox to symptomatic patients undergoing coronary artery calcium score assessment. However, biological explanation(s) of this paradox remains unanswered.
authors.affiliation: Department of Medicine, The Methodist Hospital, Houston, TX 77030, USA.
authors.forename: Kongkiat
authors.identifier: 0000-0001-7825-6493
authors.initials: K
authors.lastname: Chaikriangkrai
authors.affiliation: Department of Medicine, The Methodist Hospital, Houston, TX 77030, USA.
authors.forename: Mahwash
authors.initials: M
authors.lastname: Kassi
authors.affiliation: Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, TX 77030, USA.
authors.forename: Sayf
authors.initials: S
authors.lastname: Khaleel Bala
authors.affiliation: Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, TX 77030, USA.
authors.forename: Faisal
authors.initials: F
authors.lastname: Nabi
authors.affiliation: Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, TX 77030, USA.
authors.forename: Su Min
authors.identifier: 0000-0003-2321-4063
authors.initials: SM
authors.lastname: Chang