title: Evaluation of Pediatric Bleeding Questionnaire in Turkish Children With Von Willebrand Disease and Platelet Function Disorders.
abstract: The diagnosis of mild bleeding disorders is not easy as most of the "healthy" individuals also report bleeding symptoms. In order to get a precise bleeding history, Pediatric Bleeding Questionnaire (PBQ) has been developed. In our study, Turkish children diagnosed with Von Willebrand disease (VWD), platelet function defect (PFD), and healthy children without any symptoms (control group 1) and healthy children with symptoms but found hemostatically normal (control group 2) were analyzed with PBQ. The cut off level for "positive bleeding score" was found to be ≥2 (area under the curve [AUC]: 0.785, 95% confidence interval [CI]: 0.718-0.852). The sensitivity, specificity, positive predictive value, and negative predictive value of PBQ to define VWD versus control group 1 was 100%, 97.4%, 96.4%, and 100%; VWD versus control group 2 was 100%, 53.1%, 64.3%, and 100%; PFD versus control group 1 was 93.3%, 53.1%, 73.7%, and 85%; and PFD versus control group 2 was 93.3%, 53.1%, 73.7%, and 85%, respectively.
authors.affiliation: Department of Pediatric Hematology and Oncology, Gaziantep Childrens' Hospital, Gaziantep, Turkey draida@yahoo.com.
authors.forename: Burcu
authors.initials: B
authors.lastname: Belen
authors.affiliation: Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey.
authors.forename: Ulker
authors.initials: U
authors.lastname: Kocak
authors.affiliation: Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey.
authors.forename: Melek
authors.initials: M
authors.lastname: Isik
authors.affiliation: Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey.
authors.forename: Ebru Yilmaz
authors.initials: EY
authors.lastname: Keskin
authors.affiliation: Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey.
authors.forename: Nergiz
authors.initials: N
authors.lastname: Oner
authors.affiliation: Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey.
authors.forename: Ertan
authors.initials: E
authors.lastname: Sal
authors.affiliation: Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey.
authors.forename: Zuhre
authors.initials: Z
authors.lastname: Kaya
authors.affiliation: Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey.
authors.forename: Idil
authors.initials: I
authors.lastname: Yenicesu
authors.affiliation: Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey.
authors.forename: Turkiz
authors.initials: T
authors.lastname: Gursel
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006470:Hemorrhage / Q000175:diagnosis*; D006801:Humans; D008297:Male; D011795:Surveys and Questionnaires; D014421:Turkey; D014842:von Willebrand Diseases / Q000175:diagnosis*
keywords: bleeding; platelet dysfunction; von Willebrand factor