title: MCRs reshaped into a switchable microwave-assisted protocol toward 5-aminoimidazoles and dihydrotriazines.
abstract: A tunable microwave-assisted protocol for the synthesis of two biologically relevant families of heterocycles has been designed. Via a simple switch of reaction conditions, the same starting materials can be engaged in either an improved synthesis of the dihydrotriazine scaffold or a novel, first-in-class MCR to render the challenging 5-aminoimidazole nucleus in a single step. An additional first in class MCR is also reported utilizing guanidines to afford 2,5-aminoimidazoles.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721.
authors.forename: Christan E
authors.initials: CE
authors.lastname: Bell
authors.affiliation: College of Pharmacy, Department of Pharmacology and Toxicology, BIO5 Oro Valley, 1580 E. Hanley Blvd., The University of Arizona, Oro Valley, AZ 85737.
authors.forename: Arthur Y
authors.initials: AY
authors.lastname: Shaw
authors.affiliation: College of Pharmacy, Department of Pharmacology and Toxicology, BIO5 Oro Valley, 1580 E. Hanley Blvd., The University of Arizona, Oro Valley, AZ 85737.
authors.forename: Fabio
authors.initials: F
authors.lastname: De Moliner
authors.affiliation: College of Pharmacy, Department of Pharmacology and Toxicology, BIO5 Oro Valley, 1580 E. Hanley Blvd., The University of Arizona, Oro Valley, AZ 85737.
authors.forename: Christopher
authors.initials: C
authors.lastname: Hulme
keywords: Imidazole; Multicomponent Reaction; Strecker; Trimethylsilylcyanide