title: Orthostatic blood pressure dysregulation and polymorphisms of β-adrenergic receptor genes in hypertensive patients.
abstract: The genetic susceptibility to orthostatic blood pressure dysregulation remains poorly understood. The association between polymorphisms of beta-adrenergic receptor (β-AR) genes and orthostatic blood pressure dysregulation in hypertensive patients was investigated. Two polymorphisms of β1 -AR (Arg389/Gly) and β2 -AR (Arg16/Gly) were genotyped in untreated hypertensive patients and normotensive patients. In patients with untreated hypertension, the frequency of β1 -AR Gly389 homozygote was significantly higher in patients with orthostatic hypotension (OH) (P<.0001) and lower in patients with orthostatic hypertension (OHT) (P=.002) as compared with patients with orthostatic normotension (ONT) even after Bonferroni correction. After analysis by sex and adjustment for conventional risk factors, the β1 -AR Gly389 homozygote conferred about a 3-fold risk of OH and independently predicted a 6.5 mm Hg greater orthostatic SBP decrease (GG -8.9±13 mm Hg vs CC+CG -2.4±12 mm Hg, P<.001) only in female hypertensive patients. The association of β2 -AR Arg16/Gly with OH was not significant after adjustment for conventional risk factors. In normotensive patients, no association was identified between these two polymorphisms and OHT or OH. These results indicated that the β1 -AR Arg389/Gly polymorphism may be associated with increased risk of OH in female hypertensive patients.
authors.affiliation: State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.forename: Yahui
authors.initials: Y
authors.lastname: Lin
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.forename: Yibo
authors.initials: Y
authors.lastname: Wang
authors.forename: Jingzhou
authors.initials: J
authors.lastname: Chen
authors.forename: Hu
authors.initials: H
authors.lastname: Wang
authors.forename: Xianliang
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Fan
authors.forename: Rutai
authors.initials: R
authors.lastname: Hui
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000235:genetics*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004244:Dizziness / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006720:Homozygote; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007024:Hypotension, Orthostatic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011943:Receptors, Adrenergic, beta / Q000235:genetics*; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D012189:Retrospective Studies; D012737:Sex Factors
chemical_list: D011943:Receptors, Adrenergic, beta; D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2