title: Saccharomyces cerevisiae essential genes with an Opi- phenotype.
abstract: The overproduction and secretion of inositol (i.e., Opi(-)) phenotype is associated with defects in regulation of phospholipid biosynthesis in yeast. Here we report a screen of the essential yeast gene set using a conditional-expression library. This screen identified novel functions previously unknown to affect phospholipid synthesis.
authors.affiliation: Department of Microbiology, and Molecular Cellular Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts 01003.
authors.forename: Bryan
authors.initials: B
authors.lastname: Salas-Santiago
authors.forename: John M
authors.initials: JM
authors.lastname: Lopes
mesh_terms: D016000:Cluster Analysis; D020043:Genes, Essential; D051548:Histone Acetyltransferases / Q000235:genetics / Q000378:metabolism; D007294:Inositol / Q000378:metabolism*; D010641:Phenotype; D010743:Phospholipids / Q000096:biosynthesis; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D010743:Phospholipids; D029701:Saccharomyces cerevisiae Proteins; D007294:Inositol; D051548:Histone Acetyltransferases; C504740:NuA4 protein, S cerevisiae
keywords: inositol; phospholipid synthesis; regulation; transcription; yeast