title: Asymmetric organocatalytic direct C(sp²)-H/C(sp³)-H oxidative cross-coupling by chiral iodine reagents.
abstract: An asymmetric organocatalytic direct C-H/C-H oxidative coupling reaction of N(1),N(3)-diphenylmalonamides has been well established by using chiral organoiodine compounds as catalysts, wherein four C-H bonds were stereoselectively functionalized to give structurally diverse spirooxindoles with high levels of enantioselectivity. More importantly, the findings indicated that chiral hypervalent organoiodine reagents can serve as alternative catalysts for the creation of enantioselective functionalization of inactive C-H bonds.
authors.affiliation: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026 (China).
authors.forename: Hua
authors.initials: H
authors.lastname: Wu
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: He
authors.forename: Lue
authors.initials: L
authors.lastname: Xu
authors.forename: Dong-Yang
authors.initials: DY
authors.lastname: Zhang
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong
keywords: CH functionalization; asymmetric catalysis; chirality; cross-coupling; organoiodine