title: Disposition of fragrance ingredient [14C]1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone in male Fisher rats following oral administration and dermal application.
abstract: 1. Disposition of 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (β-OTNE), a fragrance ingredient in variety of consumer products, was investigated following a single oral (20 mg/kg) or a dermal (55 or 550 mg/kg) dose of [(14)C]β-OTNE to male Fisher rats. 2. Following oral administration, 28% and 39% of the dose was recovered in urine and feces, respectively, 48 h following administration. About 73% of a 20 mg/kg dose was excreted in bile within 48 h post-administration supporting significant oral absorption of [(14)C]β-OTNE. 3. Following dermal application to a covered site, absorption of [(14)C]β-OTNE 96 h following application was low (ca. 14%) and dose-independent. When the dose site was uncovered, the absorption increased to ca. 33% (55 mg/kg) and ca. 72% (550 mg/kg). 4. [(14)C]β-OTNE was distributed to tissues following both routes of exposure with the highest radioactive equivalents found in bladder, liver, kidney, adipose and pancreas. 5. Elimination of [(14)C]β-OTNE equivalents in blood and tissues was slow following both oral and dermal application suggesting potential for accumulation following multiple exposure.
authors.affiliation: Division of National Toxicology Program, National Institute of Environmental Health Sciences , Research Triangle Park, NC , USA.
authors.forename: Suramya
authors.initials: S
authors.lastname: Waidyanatha
authors.forename: Kristen
authors.initials: K
authors.lastname: Ryan
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D002250:Carbon Radioisotopes; D007536:Isomerism; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D010476:Perfume / Q000032:analysis*; D011851:Radioactivity; D011916:Rats, Inbred F344; D013997:Time Factors; D014018:Tissue Distribution / Q000187:drug effects
chemical_list: D002250:Carbon Radioisotopes; D009281:Naphthalenes; D010476:Perfume; C542745:1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone
keywords: 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone; biliary excretion; dermal absorption; enterohepatic recirculation; fragrance ingredient; oral absorption