title: Association between haptoglobin 2-2 genotype and coronary artery disease and its severity in a tunisian population.
abstract: Haptoglobin (Hp) polymorphism generates three common human genotypes (Hp1-1, Hp2-1, and Hp2-2), having functional differences, related to the risk of development of cardiovascular diseases. These functions are a consequence of hemoglobin binding that leads to the synthesis of an antioxidant like ferritin. We explored the association of Hp polymorphism with significant coronary stenosis (SCS) and its severity within 400 Tunisian patients, using genotyping, biochemical parameters, and the Gensini score. After adjustments for age and gender, Hp2-2 was associated with the highest ferritin but the lowest Hp concentrations. After adjustments for confounding parameters, the OR of SCS associated with Hp2-2 was 1.74 (95% CI 1.18-2.58; p = 0.005). This effect was enhanced within diabetics (OR 1.90, 95% CI 1.11-3.24; p = 0.018), obese subjects (OR 1.98, 95% CI 1.10-4.86; p = 0.034), and smokers (OR 4.17, 95% CI 1.54-1.29; p = 0.005). The Hp2-2 genotype is associated with an increase in SCS especially in diabetics, the obese, and smokers.
authors.affiliation: Biochemistry Department, LR 12 SP11, Sahloul University Hospital, 4054, Sousse, Tunisia.
authors.forename: Amira
authors.initials: A
authors.lastname: Moussa
authors.forename: Jihène
authors.initials: J
authors.lastname: Rejeb
authors.forename: Asma
authors.initials: A
authors.lastname: Omezzine
authors.forename: Lamia
authors.initials: L
authors.lastname: Rebhi
authors.forename: Imen
authors.initials: I
authors.lastname: Boumaiza
authors.forename: Slim
authors.initials: S
authors.lastname: Kacem
authors.forename: Nabila
authors.initials: N
authors.lastname: Ben Rejeb
authors.forename: Essia
authors.initials: E
authors.lastname: Boughzala
authors.forename: Ahmed
authors.initials: A
authors.lastname: Ben Abdelaziz
authors.forename: Ali
authors.initials: A
authors.lastname: Bouslama
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D023921:Coronary Stenosis / Q000235:genetics / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D005838:Genotype; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index; D012907:Smoking / Q000235:genetics; D014416:Tunisia
chemical_list: D006242:Haptoglobins