title: Evaluation of the extract of Zeyheria tuberculosa with a view to products for wound healing.
abstract: OBJECTIVE
  to evaluate the antimicrobial, cytotoxic and healing activities of the ethanolic extract of the stems of Z. tuberculosa via topical use and/or oral ingestion.
  
  
  METHODS
  antimicrobial assays in vitro using the disk diffusion method, the Artemia salina toxicity test, and in vivo assays with Wistar rats. From these was collected clinical, histological and biochemical data for evaluating the healing process.
  
  
  RESULTS
  in vitro antimicrobial testing showed activity in relation to Streptococcus pyogenes, Staphylococcus aureus and Staphylococcus epidermidis, with zones of inhibition of 18, 14 and 10 mm, respectively. The best minimum inhibitory concentration was 62.5 µg/ml for S. aureus, this bacteria being chosen for the in vitro assays. Animals treated with the ointments with the extract of Z. tuberculosa showed the best results in the reduction of the wound diameter, data confirmed by the presence of re-epithelialization in the histological samples.
  
  
  CONCLUSIONS
  the extract was shown to be promising for the continuation of studies which may identify the active ingredients responsible for the pharmacological activity and its mechanism of action in the process of wound healing, so as to develop a product which may be used as an alternate means in the repair of infected cutaneous wounds.
authors.affiliation: Universidade Federal de Alagoas, Escola de Enfermagem e Farmácia, MaceióAL, Brazil, Doctoral student, Rede do Nordeste de Biotecnologia, Carpina, PE, Brazil. Assitant Professor, Escola de Enfermagem e Farmácia, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Patrícia de Albuquerque
authors.initials: Pde A
authors.lastname: Sarmento
authors.affiliation: Universidade Federal de Alagoas, Faculdade de Nutrição, MaceióAL, Brazil, PhD, Associate Professor, Faculdade de Nutrição, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Terezinha da Rocha
authors.initials: Tda R
authors.lastname: Ataíde
authors.affiliation: PhD, Adjunct Professor, Faculdade de Medicina, Universidade Federal de Alagoas, Maceió, AL, Brazil, Universidade Federal de Alagoas, Faculdade de Medicina, MaceióAL, Brazil.
authors.forename: Ana Paula Fernandes
authors.initials: AP
authors.lastname: Barbosa
authors.affiliation: PhD, Adjunct Professor, Faculdade de Medicina, Universidade Federal de Alagoas, Maceió, AL, Brazil, Universidade Federal de Alagoas, Faculdade de Medicina, MaceióAL, Brazil.
authors.forename: Ana Paula de
authors.initials: AP
authors.lastname: Souza e Pinto
authors.affiliation: Universidade Federal de Alagoas, Escola de Enfermagem e Farmácia, MaceióAL, Brazil, PhD, Associate Professor, Escola de Enfermagem e Farmácia, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: João Xavier de
authors.initials: JX
authors.lastname: Araújo-Júnior
authors.affiliation: Universidade Federal de Alagoas, Escola de Enfermagem e Farmácia, MaceióAL, Brazil, PhD, Adjunct Professor, Escola de Enfermagem e Farmácia, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Ingrid Martins Leite
authors.initials: IM
authors.lastname: Lúcio
authors.affiliation: Universidade Federal de Alagoas, Escola de Enfermagem e Farmácia, MaceióAL, Brazil, PhD, Adjunct Professor, Escola de Enfermagem e Farmácia, Universidade Federal de Alagoas, Maceió, AL, Brazil.
authors.forename: Maria Lysete de Assis
authors.initials: ML
authors.lastname: Bastos
mesh_terms: D000818:Animals; D029402:Bignoniaceae; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010936:Plant Extracts