title: Cellular targets of regulatory B cell-mediated suppression.
abstract: Regulatory B cells (Bregs) are defined by their ability to restrain inflammatory responses both in vivo and in vitro. Interleukin 10 (IL-10) production by Bregs is thought to be central to their ability to regulate inflammation, largely due to IL-10s' ability to suppress pro-inflammatory cytokine production by effector lymphocytes and to maintain the differentiation of regulatory T cells (Tregs). However, with an increase in available published data, it has become evident that Bregs utilize a number of suppressive mechanisms in order to alter the activation of a variety of different lymphocytes. Here, we summarize the multiplicity of cellular targets of Breg-mediated suppression and describe the mechanisms employed by Bregs to suppress chronic inflammatory responses.
authors.affiliation: Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, United Kingdom.
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Rosser
authors.affiliation: Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, United Kingdom.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Blair
authors.affiliation: Centre for Rheumatology, Division of Medicine, University College London, 5 University Street, London WC1E 6JF, United Kingdom. Electronic address: c.mauri@ucl.ac.uk.
authors.forename: Claudia
authors.initials: C
authors.lastname: Mauri
mesh_terms: D000818:Animals; D060151:B-Lymphocytes, Regulatory / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents; D016753:Interleukin-10
keywords: Regulatory B cells; Tolerance