title: Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case-control study.
abstract: BACKGROUND
  The aim of this study was to determine the association between 25-hydroxyvitamin D (25-OHD) levels at the onset of critical illness and the development of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in patients with sepsis or trauma.
  
  
  METHODS
  We performed two nested case-control studies of 478 patients with sepsis and trauma with or without ALI/ARDS admitted to the medical, surgical and trauma ICUs of a tertiary-care center. Cases consisted of patients with either sepsis or trauma and ALI/ARDS; controls consisted of equivalent numbers of matched patients with either sepsis or trauma alone. We measured serum 25-OHD levels the morning after ICU admission and used multivariable regression to assess the relationship between 25-OHD and diagnosis of ALI/ARDS during the first four ICU days, controlling for age, gender, diabetes, smoking status and season.
  
  
  RESULTS
  25-OHD levels did not differ between cases with ALI/ARDS and controls in either the sepsis or trauma cohorts. Using a conditional logistic regression model, sepsis patients during the winter season with higher 25-OHD levels were more likely to develop acute lung injury (odds ratio 1.68, 95% confidence interval of 1.05 to 2.69, P = 0.03). This association did not hold for the trauma cohort in either season. Sepsis and trauma patients had a lower risk of hospital mortality at higher 25-OHD levels but neither relationship reached significance. Higher one-year mortality after trauma was associated with lower 25-OHD levels (HR 0.50, CI 0.35,0.72 P = 0.001).
  
  
  CONCLUSIONS
  Serum 25-OHD measured early after admission to intensive care is not associated with the development of acute lung injury, hospital or one-year mortality in critically ill patients with sepsis although lower 25-OHD levels were associated with higher one-year mortality in patients with severe trauma.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Barnett
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Zhao
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Koyama
authors.forename: David R
authors.initials: DR
authors.lastname: Janz
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Wang
authors.forename: Addison K
authors.initials: AK
authors.lastname: May
authors.forename: Gordon R
authors.initials: GR
authors.lastname: Bernard
authors.affiliation: Division of Allergy, Pulmonary and Critical Care Medicine in the Department of Medicine, Vanderbilt University, T1218 MCN, 1161 21st Avenue South, Nashville, TN, USA. Lorraine.ware@vanderbilt.edu.
authors.forename: Lorraine B
authors.initials: LB
authors.lastname: Ware