title: [Nocturnal heart rhythm disorder in patients with obstructive sleep apnea syndrome].
abstract: OBJECTIVE
  To explore the clinical characteristics of patients with obstructive sleep apnea syndrome (OSAS) and nocturnal arrhythmia.
  
  
  METHODS
  During September 2010 to August 2011, a total of 446 subjects were recruited from Department of Sleep Breathing Disorder, Third Hospital, Hebei Medical University to receive polysomnography examination and electrocardiogram monitoring. According to the results, they were classified as mild (5 ≤ AHI < 15/h) or moderate (15 ≤ AHI < 40/h) or severe (AHI ≥ 40/h) OSAS. Then the incidence of different types of arrhythmias, risk factors and the relationship with OSAS severity were examined.
  
  
  RESULTS
  Among 446 patients, the incidence of arrhythmia was 24.4% (109/446). The severity of OSAS (r = 1.857, P = 0.043) and age (r = 1.030, P = 0.003) had a positive relationship with the incidence of arrhythmias.Sinus bradycardia (79.8%, 87/109) and accidental ventricular premature beat (54.1%, 59/109) were most likely to occur than other types of arrhythmias (P < 0.01).In moderate and severity OSAS patients, the incidence of sinus bradycardia, frequent atrial premature beat, combined over two kinds of arrhythmias, atrial fibrillation and atrioventricular block were 50.0%, 0, 42.9%, 7.1%,0 and 90.9%, 14.8%, 57.9%, 4.5%, 5.7% respectively. And they were significantly higher than those of mild patients (all = 0) (all P < 0.05).
  
  
  CONCLUSIONS
  Age and severity of OSAS have a positive relationship with the incidence of nocturnal arrhythmias.Sinus bradycardia and ventricular premature beat are the most likely to occur in OSAS patients.In moderate and severe group, sinus bradycardia, frequent atrial premature beat, combined over two kinds of arrhythmias, atrial fibrillation and atrioventricular block are more commonly encountered.
authors.affiliation: Department of Sleep Breathing Disorders, Third Hospital, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Xiao-qian
authors.initials: XQ
authors.lastname: Men
authors.affiliation: Department of Sleep Breathing Disorders, Third Hospital, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Ya-kun
authors.initials: YK
authors.lastname: Wang
authors.affiliation: Department of Sleep Breathing Disorders, Third Hospital, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Sleep Breathing Disorders, Third Hospital, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Yu-qing
authors.initials: YQ
authors.lastname: Wei
authors.affiliation: Department of Sleep Breathing Disorders, Third Hospital, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Chan
authors.initials: C
authors.lastname: Xue
authors.affiliation: Department of Sleep Breathing Disorders, Third Hospital, Hebei Medical University, Shijiazhuang 050017, China.
authors.forename: Jiang-tao
authors.initials: JT
authors.lastname: Dong
authors.affiliation: Department of Sleep Breathing Disorders, Third Hospital, Hebei Medical University, Shijiazhuang 050017, China. Email: wanghanqiao99@126.com.
authors.forename: Han-qiao
authors.initials: HQ
authors.lastname: Wang
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000453:epidemiology* / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000453:epidemiology* / Q000503:physiopathology