title: Association between CC10 +38A/G polymorphism and asthma risk: A meta-analysis.
abstract: OBJECTIVE
  A number of studies conducted to assess the association between Clara cell 10-kDa protein (CC10) +38A/G polymorphism and susceptibility to asthma have yielded inconsistent and inconclusive results. In the present study, the possible association was assessed by a meta-analysis.
  
  
  METHODS
  Relevant articles were identified for the period ranging from Jan 1998 up to March 2013. Pooled odds ratios (OR) with 95% confidence intervals (CI) were appropriately derived from fixed effects or random-effects models.
  
  
  RESULTS
  Ten case-control studies with a total of 1529 asthma cases and 2399 controls were included in this meta-analysis. The association between CC10 +38A/G polymorphism and asthma risk was determined in dominant model, recessive model, additive model, and codominant model. In dominant model, CC10 +38A/G polymorphism seemed to be associated with elevated asthma risk (OR = 1.62; 95% CI, 1.23-2.12; P = 0.0005). Subgroup analyses by ethnicity also found significant associations between this polymorphism and asthma risk in Asians and Caucasians. RESULTS from other genetic models further identified this possible association.
  
  
  CONCLUSIONS
  This meta-analysis suggests that CC10 +38A/G polymorphism confers asthma risk.
authors.affiliation: Guangri Zhao, Department of Chest Surgery, Department of Chest Surgery, Guangzhou Medical University Cancer Institute and Hospital, Guangzhou, China.
authors.forename: Guangri
authors.initials: G
authors.lastname: Zhao
authors.affiliation: Xiaodan Lin, Department of Radiotherapy, Guangzhou Medical University Cancer Institute and Hospital, Guangzhou, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Lin
authors.affiliation: Ming Zhou, Department of Chest Surgery, Guangzhou Medical University Cancer Institute and Hospital, Guangzhou, China.
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.affiliation: Jian Zhao, Guangzhou Medical University Cancer Institute and Hospital, Guangzhou, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhao
keywords: Asthma; CC10; Meta-analysis; Polymorphism