title: Balanced chromosomal rearrangement in recurrent spontaneous abortions: a case report.
abstract: One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16; 6) (p12; q26) and 46, XY, t (16; 6) (p12; q26) in both partners, which induced such pregnancy complications. Chromosomal balanced translocation is one of the most common causes of recurrent spontaneous abortions (RSA). In such cases prenatal diagnosis (PND) during the 16(th) week of gestation is strongly recommended.
authors.affiliation: Student Research Assembly, Mashhad University of Medical Sciences, Iran.
authors.forename: Ahmadreza
authors.initials: A
authors.lastname: Zarifian
authors.affiliation: Student Research Assembly, Mashhad University of Medical Sciences, Iran.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Farhoodi
authors.affiliation: Student Research Assembly, Mashhad University of Medical Sciences, Iran.
authors.forename: Roya
authors.initials: R
authors.lastname: Amel
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Iran.
authors.forename: Salmeh
authors.initials: S
authors.lastname: Mirzaee
authors.affiliation: Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hassanzadeh-Nazarabadi
keywords: Chromosomal abnormality; case report; chromosomal translocation; recurrent miscarriage; spontaneous abortion