title: Fatsioside A, a rare baccharane-type glycoside inhibiting the growth of glioma cells from the fruits of Fatsia japonica.
abstract: A novel baccharane-type triterpenoid glycoside named fatsioside A (1), together with ten oleanane glycosides, were isolated from the fruits of Fatsia japonica. The structure of fatsioside A was assigned as 3β,15α,18α-trihydroxy-18,19-secolupane-12,19-dione 3-O-β-D-glucopyranosyl-(1 → 2)-β-D-glucopyranoside by extensive NMR and HRESIMS analyses. F. japonica is the third baccharane glycoside-containing species reported to date in the plant kingdom, while fatsioside A represents the first baccharane glycoside found in the Araliaceae family. Fatsioside A inhibited the growth of rat glioma C6 cells and human glioma U251 cells with IC50 values of 33.48 ± 2.01 µM and 77.58 ± 6.19 µM, respectively. Further investigation indicated that fatsioside A induced apoptosis and necrosis in glioma cells, and arrested the cell cycle at the G0/G1 phase.
authors.affiliation: Ocean College, Zhejiang University, Hangzhou, China.
authors.forename: Siran
authors.initials: S
authors.lastname: Yu
authors.affiliation: Ocean College, Zhejiang University, Hangzhou, China.
authors.forename: Xuewei
authors.initials: X
authors.lastname: Ye
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Wenxiu
authors.initials: W
authors.lastname: Xin
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Kangning
authors.initials: K
authors.lastname: Xu
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Xiao-Yuan
authors.initials: XY
authors.lastname: Lian
authors.affiliation: Ocean College, Zhejiang University, Hangzhou, China.
authors.forename: Zhizhen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis; D027481:Araliaceae / Q000737:chemistry*; D059447:Cell Cycle Checkpoints; D045744:Cell Line, Tumor; D005638:Fruit / Q000737:chemistry; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009336:Necrosis; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: C000592854:3,15,18-trihydroxy-18,19-secolupane-12,19-dione 3-O-glucopyranosyl(1-2)glucopyranoside; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins