title: Idiopathic eosinophilic pneumonia in children: the French experience.
abstract: BACKGROUND
  Idiopathic eosinophilic pneumonia is extremely rare in children and adults. We present herein the first series describing the specificities of idiopathic chronic (ICEP) and acute (IAEP) eosinophilic pneumonia in children.
  
  
  METHODS
  We retrospectively analyzed all cases of ICEP and IAEP in children that were retrieved from French Reference Centers for rare pediatric lung diseases.
  
  
  RESULTS
  Five cases of pediatric ICEP were identified. Corticosteroid or immunosuppressive therapy dramatically improved the outcome in three cases. The remaining two cases had a persistent interstitial pattern with progressive development of cystic airspace lesions. Three cases of IAEP in adolescents were reported, with one requiring four days of extracorporeal membrane oxygenation.
  
  
  CONCLUSIONS
  ICEP is a rare disease with a polymorphic clinical presentation in children. We identified patients with persistent interstitial patterns progressing to cystic airspace regions, for which the boundaries with idiopathic interstitial pneumonias are difficult to establish. We therefore propose a specific pediatric definition and classification algorithm. IAEP in children remains an inflammatory reaction of the lung to an acute toxic exposure, mainly tobacco, as in adults. International studies are required to comprehensively assess the various clinical forms of the disease as well as the appropriate therapeutic regimens.
authors.affiliation: Pediatric Pulmonology and Allergy Department, Hôpitaux pédiatriques de Nice CHU-Lenval, Nice F-06200, France. giovannini-chami.l@pediatrie-chulenval-nice.fr.
authors.forename: Lisa
authors.initials: L
authors.lastname: Giovannini-Chami
authors.forename: Alice
authors.initials: A
authors.lastname: Hadchouel
authors.forename: Nadia
authors.initials: N
authors.lastname: Nathan
authors.forename: Francois
authors.initials: F
authors.lastname: Brémont
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Dubus
authors.forename: Michael
authors.initials: M
authors.lastname: Fayon
authors.forename: Véronique
authors.initials: V
authors.lastname: Houdouin
authors.forename: Michèle
authors.initials: M
authors.lastname: Berlioz-Baudoin
authors.forename: Virginie
authors.initials: V
authors.lastname: Feret
authors.forename: Thierry
authors.initials: T
authors.lastname: Leblanc
authors.forename: Karine
authors.initials: K
authors.lastname: Morelle
authors.forename: Marc
authors.initials: M
authors.lastname: Albertini
authors.forename: Annick
authors.initials: A
authors.lastname: Clement
authors.forename: Jacques
authors.initials: J
authors.lastname: de Blic
mesh_terms: D000293:Adolescent; D001992:Bronchoalveolar Lavage Fluid; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008297:Male; D011657:Pulmonary Eosinophilia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods