title: Pulmonary pleomorphic carcinoma with rapid progression.
abstract: We describe a case of pleomorphic carcinoma showing a recurrent tumor with massive hemorrhage and myxoid change in the chest wall 2 months after complete resection. Whereas specimens from the initial surgery revealed both adenosquamous carcinoma and sarcomatous elements, the recurrent tumor predominantly consisted of a sarcomatous element. The recurrent tumor had stronger immunoreactivity for mesenchymal markers than the primary tumor, indicating that the sarcomatous element had more malignant potential than the epithelial element.
authors.affiliation: Department of Thoracic Surgery, Osaka Prefectural Hospital Organization, Osaka Prefectural Medical Center for Respiratory and Allergic Disease, Osaka, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shintani
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Ohta
authors.forename: Teruo
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Naoki
authors.initials: N
authors.lastname: Ikeda
authors.forename: Emiko
authors.initials: E
authors.lastname: Tomita
authors.forename: Kunimitsu
authors.initials: K
authors.lastname: Kawahara
mesh_terms: D000368:Aged; D001344:Autopsy; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D018196:Carcinoma, Adenosquamous / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D018450:Disease Progression; D017809:Fatal Outcome; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local; D018193:Neoplasms, Complex and Mixed / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D011013:Pneumonectomy; D012509:Sarcoma / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor
keywords: Cadherins; adenosquamous; carcinoma; epithelial-mesenchymal transition; lung neoplasms