title: Enhanced activity and stability of organophosphorus hydrolase via interaction with an amphiphilic polymer.
abstract: A simple approach to enhancing the activity and stability of organophosphorus hydrolase (OPH) is developed based on interactions between the hydrophobic poly(propylene oxide) (PPO) block of amphiphilic Pluronics and the enzyme. This strategy provides an efficient route to new formulations for decontaminating organophosphate neurotoxins.
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. bdolsen@mit.edu.
authors.forename: Minkyu
authors.initials: M
authors.lastname: Kim
authors.forename: Manos
authors.initials: M
authors.lastname: Gkikas
authors.forename: Aaron
authors.initials: A
authors.lastname: Huang
authors.forename: Jeon Woong
authors.initials: JW
authors.lastname: Kang
authors.forename: Nisaraporn
authors.initials: N
authors.lastname: Suthiwangcharoen
authors.forename: Ramanathan
authors.initials: R
authors.lastname: Nagarajan
authors.forename: Bradley D
authors.initials: BD
authors.lastname: Olsen
mesh_terms: D043303:Aryldialkylphosphatase / Q000737:chemistry* / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D020442:Poloxamer / Q000737:chemistry / Q000378:metabolism*; D011108:Polymers / Q000737:chemistry / Q000378:metabolism*; D011409:Propylene Glycols / Q000737:chemistry / Q000378:metabolism*; D013501:Surface-Active Agents / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011108:Polymers; D011409:Propylene Glycols; D013501:Surface-Active Agents; D020442:Poloxamer; C012504:polypropylene glycol; D043303:Aryldialkylphosphatase