title: Taro corms mucilage/HPMC based transdermal patch: an efficient device for delivery of diltiazem hydrochloride.
abstract: The aim of this work is to examine the effectiveness of mucilage/hydroxypropylmethylcellulose (HPMC) based transdermal patch (matrix type) as a drug delivery device. We have successfully extracted mucilage from Colocasia esculenta (Taro) corms and prepared diltiazem hydrochloride incorporated mucilage/HPMC based transdermal patches using various wt% of mucilage by the solvent evaporation technique. Characterization of both mucilage and transdermal patches has been done by several techniques such as Molisch's test, organoleptic evaluation of mucilage, mechanical, morphological and thermal analysis of transdermal patches. Skin irritation test is studied on hairless Albino rat skin showing that transdermal patches are apparently free of potentially hazardous skin irritation. Fourier transform infrared analysis shows that there is no interaction between drug, mucilage and HPMC while scanning electron microscopy shows the surface morphology of transdermal patches. In vitro drug release time of mucilage-HPMC based transdermal patches is prolonged with increasing mucilage concentration in the formulation.
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Gunjan
authors.initials: G
authors.lastname: Sarkar
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Nayan Ranjan
authors.initials: NR
authors.lastname: Saha
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Indranil
authors.initials: I
authors.lastname: Roy
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Amartya
authors.initials: A
authors.lastname: Bhattacharyya
authors.affiliation: Department of Physiology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Madhura
authors.initials: M
authors.lastname: Bose
authors.affiliation: Department of Physiology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.
authors.forename: Roshnara
authors.initials: R
authors.lastname: Mishra
authors.affiliation: Department of Chemical and Biological Engineering, Industrial Membrane Research Institute, University of Ottawa, 161 Louis Pasteur St., Ottawa, ON, K1N 6N5, Canada.
authors.forename: Dipak
authors.initials: D
authors.lastname: Rana
authors.affiliation: Swasthya Bhavan, Department of Health and Family Welfare, Government of West Bengal, Salt Lake, Kolkata 700091, India.
authors.forename: Debashis
authors.initials: D
authors.lastname: Bhattacharjee
authors.affiliation: Department of Polymer Science and Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India. Electronic address: dipankar.chattopadhyay@gmail.com.
authors.forename: Dipankar
authors.initials: D
authors.lastname: Chattopadhyay
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods; D031060:Colocasia / Q000737:chemistry*; D004110:Diltiazem / Q000008:administration & dosage* / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D065347:Hypromellose Derivatives / Q000008:administration & dosage / Q000737:chemistry; D062087:Plant Mucilage / Q000008:administration & dosage / Q000737:chemistry*; D051381:Rats; D054772:Rats, Hairless; D012867:Skin / Q000187:drug effects*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D057968:Transdermal Patch
chemical_list: D004337:Drug Carriers; D062087:Plant Mucilage; D012997:Solvents; D065347:Hypromellose Derivatives; D004110:Diltiazem
keywords: In vitro drug release; Mechanical properties; Mucilage; Skin irritation test; Transdermal patch