title: [6]-gingerol as a cancer chemopreventive agent: a review of its activity on different steps of the metastatic process.
abstract: For many years, ginger or ginger root, the rhizome of the plant Zingiber officinale, has been consumed as a delicacy, medicine, or spice. Several studies have been conducted on the medicinal properties of ginger against various disorders, including cancer. Cancer is the second leading cause of death, and chemoprevention is defined as the use of natural or synthetic substances to prevent cancer initiation or progression. Evidence that ginger-derived compounds have inhibitory effects on various cancer cell types is increasingly being reported in the scientific literature. In this review we focused on the cancer chemopreventive effects of [6]-gingerol, the major pungent component of ginger, and its impact on different steps of the metastatic process.
authors.forename: Juliana
authors.initials: J
authors.lastname: Poltronieri
authors.forename: Amanda B
authors.initials: AB
authors.lastname: Becceneri
authors.forename: Angelina M
authors.initials: AM
authors.lastname: Fuzer
authors.forename: Julio Cesar C
authors.initials: JC
authors.lastname: Filho
authors.forename: Ana Carolina B M
authors.initials: AC
authors.lastname: Martin
authors.forename: Paulo Cezar
authors.initials: PC
authors.lastname: Vieira
authors.forename: Normand
authors.initials: N
authors.lastname: Pouliot
authors.affiliation: Departamento de Gerontologia, Universidade Federal de São Carlos, Rodovia Washington Luís, Km 235, São Carlos, SP, 13565-905, Brazil. mcominetti@ufscar.br.
authors.forename: Márcia R
authors.initials: MR
authors.lastname: Cominetti
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D002396:Catechols / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002465:Cell Movement / Q000187:drug effects*; D005233:Fatty Alcohols / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D020939:Zingiber officinale / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000517:prevention & control*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D043925:Angiogenesis Inducing Agents; D016588:Anticarcinogenic Agents; D002396:Catechols; D005233:Fatty Alcohols; D017382:Reactive Oxygen Species; C007845:gingerol