title: A physiologically based toxicokinetic and toxicodynamic model links the tissue distribution of benzo[a]pyrene and toxic effects in the scallop Chlamys farreri.
abstract: A physiologically based toxicokinetic and toxicodynamic (PBTK-TD) model was developed for benzo[a]pyrene (B[a]P) in scallop Chlamys farreri. The PBTK model structure consisted of gill, digestive gland, adductor muscle, hemolymph and other tissues. In TD modeling, aryl hydrocarbon hydroxylase (AHH) activity assay, comet assay, protein carbonyl measurement and lipid peroxidation level determination in digestive gland were used as biomarkers to reflect toxic effects. We integrated B[a]P concentration and biomarkers by using sigmoid Emax model in digestive gland. The PBTK-TD model predicted the B[a]P concentrations within each organ compartment and the toxic effects in digestive gland. The results showed that the predicted and measured data in different organs were in good agreement and comet assay was considered as the best biomarker. This model would serve as a useful tool for pollution monitoring and food security.
authors.affiliation: The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.affiliation: The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China. Electronic address: panlq@ouc.edu.cn.
authors.forename: Luqing
authors.initials: L
authors.lastname: Pan
authors.affiliation: The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Huizan
authors.initials: H
authors.lastname: Yang
authors.affiliation: The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D001564:Benzo(a)pyrene / Q000493:pharmacokinetics* / Q000633:toxicity*; D015415:Biomarkers / Q000378:metabolism; D020552:Comet Assay; D004784:Environmental Monitoring / Q000379:methods; D041981:Gastrointestinal Tract / Q000378:metabolism; D005880:Gills / Q000378:metabolism; D006458:Hemolymph / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism; D049897:Pectinidae / Q000187:drug effects* / Q000378:metabolism; D050050:Protein Carbonylation / Q000187:drug effects; D066007:Toxicokinetics; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics* / Q000633:toxicity*
chemical_list: D015415:Biomarkers; D014874:Water Pollutants, Chemical; D001564:Benzo(a)pyrene
keywords: Benzo[a]pyrene; Bioaccumulation; Biomarker; Chlamys farrer; PBTK-TD model