title: A new pyrrolosesquiterpene isolated from cultures of Streptomyces sp.
abstract: One new pyrrolosesquiterpene 1 was isolated from the cultures of the soil actinomycete Streptomyces sp. Hd7-21. Its structure was elucidated by extensive spectroscopic analyses including MS and one-dimensional and two-dimensional NMR data. Compound 1 showed moderate cytotoxic activity against a panel of human cancer cell lines.
authors.affiliation: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
authors.forename: Dong-Ze
authors.initials: DZ
authors.lastname: Liu
authors.affiliation: Northeast Agricultural University, Harbin, China.
authors.forename: Bo-Wen
authors.initials: BW
authors.lastname: Liang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012988:Soil Microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D012717:Sesquiterpenes