title: Analysis of gene expression profiles associated with functional recovery after spinal cord injury caused by sema4D knockdown in oligodendrocytes.
abstract: We previously showed that sema4D Knockdown in oligodendrocytes promotes functional recovery after spinal cord injury. In this paper, we examined gene expression profiles associated with functional recovery by PCR array. For general observation during first 4 weeks, we found that sema4D knockdown could reduce edema and stimulate SCEP. Further, PCR array analysis indicated sema4D knockdown in OPCs inhibited wound tissue angiogenesis and inflammation genes expression and upregulated axon regeneration genes expression at early phase. Our findings provided the molecular mechanism for its potential application.
authors.affiliation: Department of Spine Surgery, Liaocheng People's Hospital Affiliated to Taishan Medical University, Liaocheng, 252000, Shandong, People's Republic of China.
authors.forename: Hong-Lei
authors.initials: HL
authors.lastname: Zhang
authors.forename: Zhen-Song
authors.initials: ZS
authors.lastname: Jiang
authors.forename: Fu-Wu
authors.initials: FW
authors.lastname: Wang
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics*; D001369:Axons / Q000378:metabolism; D005071:Evoked Potentials / Q000235:genetics; D005260:Female; D020869:Gene Expression Profiling; D055785:Gene Knockdown Techniques; D018919:Neovascularization, Physiologic / Q000235:genetics; D009836:Oligodendroglia / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000235:genetics*; D039961:Semaphorins / Q000172:deficiency* / Q000235:genetics*; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000209:etiology / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*
chemical_list: D015703:Antigens, CD; C093224:CD100 antigen; D039961:Semaphorins