title: Association between six genetic polymorphisms and colorectal cancer: a meta-analysis.
abstract: OBJECTIVE
  The aim of this study was to determine whether six genetic polymorphisms confer susceptibility to colorectal cancer (CRC).
  
  
  METHODS
  A systematic search for candidate genes of CRC was performed among several online databases, including PubMed, Embase, Web of Science, the Cochrane Library, CNKI, and Wanfang online libraries. After a comprehensive filtering procedure, we harvested five genes, including MGMT (rs12917 and rs2308321), ADH1B (rs1229984), SOD2 (rs4880), XPC (rs2228001), and PPARG (rs1801282). Using the REVMAN and Stata software, six meta-analyses were conducted for associations between CRC and the just-mentioned genetic variants.
  
  
  RESULTS
  A total of 34 comparative studies among 17,289 cases and 54,927 controls were involved in our meta-analyses. Significant association was found between ADH1B rs1229984 polymorphism and CRC (p=0.03, odds ratio [OR]=1.18, 95% confidence interval [CI]=1.01-1.36). We also found significant association between PPARG rs1801282 polymorphism and CRC (p=0.004, OR=1.498, 95% CI=1.139-1.970), and this significant association is specific in Caucasians (p=0.004, OR=1.603, 95% CI=1.165-2.205).
  
  
  CONCLUSIONS
  The current meta-analysis has established that ADH1B (rs1229984) and PPARG (rs1801282) are two risk variants of CRC.
authors.affiliation: 1 Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University , Ningbo, China .
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Lingyan
authors.initials: L
authors.lastname: Wang
authors.forename: Qi
authors.initials: Q
authors.lastname: Liao
authors.forename: Leiting
authors.initials: L
authors.lastname: Xu
authors.forename: Yi
authors.initials: Y
authors.lastname: Huang
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhang
authors.forename: Huadan
authors.initials: H
authors.lastname: Ye
authors.forename: Xuting
authors.initials: X
authors.lastname: Xu
authors.forename: Meng
authors.initials: M
authors.lastname: Ye
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000235:genetics*; D015254:DNA Modification Methylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D047495:PPAR gamma / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D013482:Superoxide Dismutase / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics; D000099156:Superoxide Dismutase 2
chemical_list: D000426:Alcohol Dehydrogenase; D015254:DNA Modification Methylases; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins; D047495:PPAR gamma; D013482:Superoxide Dismutase; D025521:Tumor Suppressor Proteins; D000099156:Superoxide Dismutase 2; C086984:XPC protein, human; C489332:ADH1B protein, human; C515491:MGMT protein, human