title: Association of interleukin-1β -511 C/T polymorphism with tobacco-associated cancer in northeast India: a study on oral and gastric cancer.
abstract: The IL-1β -511 C/T polymorphism is associated with increased IL-1 production and with increased risk of developing cancers. In this study, 251 patients (125 with gastric cancer [GC] and 126 with oral cancer [OC]) and 207 normal controls from northeast (NE) India were genotyped for the IL-1β -511 C/T polymorphism by PCR-restriction fragment length polymorphism (RFLP) and sequencing. Analysis of results showed betel-quid chewing to be a major risk factor (OR = 2.01, 95% CI = 1.05-3.87; P = 0.035) for OC. Inheritance of the IL-1β -511 CT or TT resulted in a 2.6- to 3.05-fold increase in the risk of developing OC relative to that of participants who possessed the reference genotype (OR = 2.57, 95% CI = 1.06-6.22; P = 0.036 and OR = 3.05, 95% CI = 1.22-7.63; P = 0.017), after adjusting for potential confounders. The dominant genetic model also confirmed the presence of the T allele as a significant risk factor for OC (OR = 2.72, 95% CI = 1.15-6.42; P = 0.02). In GC, interaction of the CT genotype with tobacco and betel-quid chewing habits conferred a significant 78% and 89% reduced risk of cancer, respectively. In conclusion, for the NE Indian population, the IL-1β -511 CC and CT genotypes were significantly associated with increased risk of OC. However, the interaction of the CT genotype with risk habits may play a preventive role for GC but not for OC.
authors.affiliation: National Institute of Pathology, Safdarjang Hospital Campus, Indian Council of Medical Research, New Delhi, India.
authors.forename: Meena
authors.initials: M
authors.lastname: Lakhanpal
authors.affiliation: National Institute of Pathology, Safdarjang Hospital Campus, Indian Council of Medical Research, New Delhi, India.
authors.forename: Dhirendra Singh
authors.initials: DS
authors.lastname: Yadav
authors.affiliation: National Institute of Pathology, Safdarjang Hospital Campus, Indian Council of Medical Research, New Delhi, India.
authors.forename: Thoudam Regina
authors.initials: TR
authors.lastname: Devi
authors.affiliation: National Institute of Pathology, Safdarjang Hospital Campus, Indian Council of Medical Research, New Delhi, India.
authors.forename: Laishram Chandreshwor
authors.initials: LC
authors.lastname: Singh
authors.affiliation: National Institute of Medical Statistics, Indian Council of Medical Research, New Delhi, India.
authors.forename: Khangembam Jitenkumar
authors.initials: KJ
authors.lastname: Singh
authors.affiliation: National Institute of Pathology, Safdarjang Hospital Campus, Indian Council of Medical Research, New Delhi, India.
authors.forename: Santhi P
authors.initials: SP
authors.lastname: Latha
authors.affiliation: National Institute of Pathology, Safdarjang Hospital Campus, Indian Council of Medical Research, New Delhi, India.
authors.forename: Pradeep Singh
authors.initials: PS
authors.lastname: Chauhan
authors.affiliation: Sir T.N.M. Hospital, Gangtok, Sikkim, India.
authors.forename: Yogesh
authors.initials: Y
authors.lastname: Verma
authors.affiliation: Civil Hospital, Aizawl, Mizoram, India.
authors.forename: Eric
authors.initials: E
authors.lastname: Zomavia
authors.affiliation: Dr. B. Barooah Cancer Institute, Guwahati, Assam, India.
authors.forename: Jagannath
authors.initials: J
authors.lastname: Sharma
authors.affiliation: Dr. B. Barooah Cancer Institute, Guwahati, Assam, India.
authors.forename: Amal
authors.initials: A
authors.lastname: Chandra Kataki
authors.affiliation: National Institute of Pathology, Safdarjang Hospital Campus, Indian Council of Medical Research, New Delhi, India.
authors.forename: Sunita
authors.initials: S
authors.lastname: Saxena
authors.affiliation: National Institute of Pathology, Safdarjang Hospital Campus, Indian Council of Medical Research, New Delhi, India. Electronic address: sujalakapur@rediffmail.com.
authors.forename: Sujala
authors.initials: S
authors.lastname: Kapur
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000483:Alleles; D001114:Areca / Q000009:adverse effects; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007194:India; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D012907:Smoking / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D014030:Tobacco, Smokeless / Q000009:adverse effects
chemical_list: D053583:Interleukin-1beta
keywords: IL-1β; cancer; northeast India; polymorphism; tobacco