title: In the beginning, there was protein phosphorylation.
abstract: The importance of reversible protein phosphorylation to cellular regulation cannot be overstated. In eukaryotic cells, protein kinase/phosphatase signaling pathways regulate a staggering number of cellular processes, including cell proliferation, cell death (apoptosis, necroptosis, necrosis), metabolism (at both the cellular and organismal levels), behavior and neurological function, development, and pathogen resistance. Although protein phosphorylation as a mode of eukaryotic cell regulation is familiar to most biochemists, many are less familiar with protein kinase/phosphatase signaling networks that function in prokaryotes. In this thematic minireview series, we present four minireviews that cover the important field of prokaryotic protein phosphorylation.
authors.affiliation: From Mercury Therapeutics, Incorporated, Woburn, Massachusetts 01801.
authors.forename: John M
authors.initials: JM
authors.lastname: Kyriakis
mesh_terms: D000818:Animals; D016923:Cell Death / Q000502:physiology; D006801:Humans; D010766:Phosphorylation / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000502:physiology*
keywords: Archaea; Bacterial Protein Kinases; Bacterial Signal Transduction; Prokaryotic Protein Kinases; Prokaryotic Signal Transduction; Protein Kinases