title: [Estimating the anti-inflammatory activity of drugs by changes in the agranulocyte/granulocyte index].
abstract: It is suggested to assess the anti-inflammatory activity using the ratio of the sums of agranulocytes and granulocytes. On the model of carrageenan-induced inflammation in the rat limbs, the anti-inflammatory activity of NSAIDs and their combinations with antihypoxants was characterized in terms of limb size, leukogram, and the proposed index of anti-inflammatory activity. A high anti-inflammatory activity was observed for a combination of hypoxen with diclofenac and acetylsalicylic acid and a combination of metaprot with diclofenac.
authors.forename: I A
authors.initials: IA
authors.lastname: Platonov
authors.forename: V E
authors.initials: VE
authors.lastname: Novikov
authors.forename: S A
authors.initials: SA
authors.lastname: Iliukhin
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology*; D002351:Carrageenan / Q000633:toxicity; D006098:Granulocytes; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy; D007958:Leukocyte Count; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002351:Carrageenan