title: A comparative study of PCNA and Ki-67 expression in dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma.
abstract: Various cell proliferation markers are used as diagnostic and prognostic tools in oral lesions. Simultaneous evaluation of these markers can increase the precision of estimation of the proliferative status of different tissues. In this study we investigated the expression of PCNA and Ki-67 as markers of cell proliferation in 15 paraffin embedded samples of each dental follicle, dentigerous cyst, unicystic ameloblastoma and ameloblastoma belonging to a total of 30 male and 30 female paients using immunohistochemistry method. Expression levels based on the intensity and the percentage of stained cells was separately analyzed for each marker with chi-square test, the results of which were significant for the two markers (P<0.05). The correlation coefficient between the two markers was found to be 0.88. A significant difference in the expression of Ki-67 and PCNA was observed in the four types of studied lesions.
authors.affiliation: Dental material research center, Babol University of Medical Sciences, Babol, Iran. ; Department of Oral and Maxillofacial Pathology, Dentistry school, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Shima
authors.initials: S
authors.lastname: Nafarzadeh
authors.affiliation: Dental material research center, Babol University of Medical Sciences, Babol, Iran. ; Department of Oral and Maxillofacial Pathology, Dentistry school, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Seyedmajidi
authors.affiliation: Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Sina
authors.initials: S
authors.lastname: Jafari
authors.affiliation: Non-communicable Pediatric Diseases Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Bijani
authors.affiliation: Dentistry school, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Rostami-Sarokolaei
keywords: Ki-67; PCNA; ameloblastoma; dental follicle; dentigerous cyst; immunohistochemistry