title: Remineralization potential of bioactive glass and casein phosphopeptide-amorphous calcium phosphate on initial carious lesion: An in-vitro pH-cycling study.
abstract: OBJECTIVE
  The aim of this study was to evaluate and compare the remineralization potential of bioactive-Glass (BAG) (Novamin(®)/Calcium-sodium-phosphosilicate) and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) containing dentifrice.
  
  
  METHODS
  A total of 30 sound human premolars were decoronated, coated with nail varnish except for a 4 mm × 4 mm window on the buccal surface of crown and were randomly divided in two groups (n = 15). Group A - BAG dentifrice and Group B - CPP-ACP dentifrice. The baseline surface microhardness (SMH) was measured for all the specimens using the vickers microhardness testing machine. Artificial enamel carious lesions were created by inserting the specimens in de-mineralizing solution for 96 h. SMH of demineralized specimens was evaluated. 10 days of pH-cycling regimen was carried out. SMH of remineralized specimens was evaluated.
  
  
  METHODS
  Data was analyzed using ANOVA and multiple comparisons within groups was done using Bonferroni method (post-hoc tests) to detect significant differences at P < 0.05 levels.
  
  
  RESULTS
  Group A showed significantly higher values (P < 0.05) when compared with the hardness values of Group B.
  
  
  CONCLUSIONS
  Within the limits; the present study concluded that; both BAG and CPP-ACP are effective in remineralizing early enamel caries. Application of BAG more effectively remineralized the carious lesion when compared with CPP-ACP.
authors.affiliation: Department of Conservative Dentistry & Endodontics, M.R. Ambedkar Dental College & Hospital, Bengaluru, Karnataka, India.
authors.forename: Adit Bharat
authors.initials: AB
authors.lastname: Mehta
authors.affiliation: Department of Conservative Dentistry & Endodontics, M.R. Ambedkar Dental College & Hospital, Bengaluru, Karnataka, India.
authors.forename: Veena
authors.initials: V
authors.lastname: Kumari
authors.affiliation: Department of Conservative Dentistry & Endodontics, M.R. Ambedkar Dental College & Hospital, Bengaluru, Karnataka, India.
authors.forename: Rani
authors.initials: R
authors.lastname: Jose
authors.affiliation: Department of Conservative Dentistry & Endodontics, M.R. Ambedkar Dental College & Hospital, Bengaluru, Karnataka, India.
authors.forename: Vajiheh
authors.initials: V
authors.lastname: Izadikhah
keywords: Bioactive glass; casein phosphopeptide-amorphous calcium phosphate; dental caries; remineralization