title: Phenolic constituents from the leaves of Cratoxylum formosum ssp. pruniflorum.
abstract: One (formosumone A, 1) new and fifteen (2-16) known phenolic compounds were isolated from the leaves of Cratoxylum formosum ssp. pruniflorumm, a substitute for the popular bitter nail tea ("Kuding Tea") generally used in Southeast Asia. Their structures were determined by extensive spectroscopic analysis and by comparison with literature data. Compound 1 possesses a rare scaffold of a flavanone coupled with a phloroglucinol moiety, representing the first example of such a scaffold from the Clusiaceae family. Among the isolates, toxyloxanthone B (11) and vismione D (12) were found to show remarkable anti-neuroinflammatory effects by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells. Additionally, toxyloxanthone B (11) exhibited significant neuroprotective effect against β-amyloid(25-35) (Aβ(25-35))-induced cell viability decrease in SH-SY5Y neuroblastoma cells.
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xiong
authors.affiliation: Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Liu
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai 200062, PR China; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, PR China; Department of Chemistry, Hoa Lu University, Ninh Binh 40000, Viet Nam.
authors.forename: Van-Binh
authors.initials: VB
authors.lastname: Bui
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
authors.forename: Zhi-Lai
authors.initials: ZL
authors.lastname: Hong
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai 200062, PR China; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, East China Normal University, Shanghai 200062, PR China; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Fan
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China.
authors.forename: Guo-Xun
authors.initials: GX
authors.lastname: Yang
authors.affiliation: Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address: jfhu@fudan.edu.cn.
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D028084:Clusiaceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000880:Anthraquinones; D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D008070:Lipopolysaccharides; D018696:Neuroprotective Agents; D010636:Phenols; D010936:Plant Extracts; D044004:Xanthones; D009569:Nitric Oxide
keywords: Anti-neuroinflammation; Clusiaceae; Cratoxylum formosum ssp. pruniflorum; Neuroprotection; Phenolic compounds