title: The role of IP3 receptor channel clustering in Ca2+ wave propagation during oocyte maturation.
abstract: During oocyte maturation, the calcium-signaling machinery undergoes a dramatic remodeling resulting in distinctly different calcium-release patterns on all organizational scales from puffs to waves. The dynamics of the Ca(2+) release wave in mature as compared to immature oocytes are defined by a slower propagation speed and longer duration of the high Ca(2+) plateau. In this chapter, we use computational modeling to identify the changes in the signaling machinery, which contribute most significantly to the alterations observed in Ca(2+) wave propagation during Xenopus oocyte maturation. In addition to loss of store-operated calcium entry and internalization of plasma membrane pumps, we propose that spatial reorganization of the IP3 receptors in the plane of the ER membrane is a key factor for the observed signaling changes in Ca(2+) wave propagation.
authors.affiliation: Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, Ohio, USA.
authors.forename: Aman
authors.initials: A
authors.lastname: Ullah
authors.affiliation: Department of Physics and Astronomy and Quantitative Biology Institute, Ohio University, Athens, Ohio, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Jung
authors.affiliation: Department of Physics, University of South Florida, Tampa, Florida, USA.
authors.forename: Ghanim
authors.initials: G
authors.lastname: Ullah
authors.affiliation: Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Doha, Qatar.
authors.forename: Khaled
authors.initials: K
authors.lastname: Machaca
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D002454:Cell Differentiation; D003600:Cytosol / Q000378:metabolism; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000378:metabolism*; D042541:Intracellular Space / Q000378:metabolism; D009865:Oocytes / Q000166:cytology* / Q000378:metabolism*; D010063:Ovum; D014982:Xenopus laevis / Q000378:metabolism*
chemical_list: D053496:Inositol 1,4,5-Trisphosphate Receptors; D002118:Calcium
keywords: Calcium channels; Calcium signaling; Calcium wave; Inositol 1,4,5, triphosphate receptors; Oocyte maturation