title: Expression and prognostic value of c-Myc and Fas (CD95/APO1) in patients with pancreatic cancer.
abstract: The identification of molecular prognostic markers for pancreatic cancer patients could provide insightful information for their management in the clinic. The aim of the study is to investigate whether or not the expressions of c-Myc and Fas (CD95/APO1) have prognostic relevance for overall survival (OS) in patients with pancreatic cancer. we used immunohistochemistry on tissue microarrays containing 162 pancreatic cancer specimens to assess the protein expression levels of c-Myc and Fas. Kaplan-Meier survival analysis demonstrated that high level of c-Myc cytoplasmic expression was significantly correlated with worse survival in patients with pancreatic cancer (P = 0.012), while high level of Fas cytoplasmic expression was significantly associated with better outcome of pancreatic cancer (P = 0.046). However, multivariate Cox model analysis showed that tumor differentiation, lymph node status and c-Myc cytoplasmic expression were significant independent prognostic factors for OS (P < 0.001, P = 0.023, P = 0.001, respectively). On the contrary, Fas cytoplasmic expression did not independently influence patient's prognosis (P = 0.249). Our data suggested that high level of c-Myc cytoplasmic expression may be considered as a valuable marker for prognosis of pancreatic cancer.
authors.affiliation: Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120, China ; Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China.
authors.forename: Chengzhi
authors.initials: C
authors.lastname: He
authors.affiliation: Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120, China.
authors.forename: Shasha
authors.initials: S
authors.lastname: Geng
authors.affiliation: Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai 201203, China.
authors.forename: Haihui
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai 201203, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Shen
authors.affiliation: Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai 201203, China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai 201203, China.
authors.forename: Shizhang
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China.
authors.forename: Ximei
authors.initials: X
authors.lastname: Chen
authors.affiliation: Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China.
authors.forename: Changqing
authors.initials: C
authors.lastname: Yang
authors.affiliation: Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China ; Shanghai Engineering Center for Molecular Medicine, National Engineering Center for Biochip at Shanghai 201203, China.
authors.forename: Hengjun
authors.initials: H
authors.lastname: Gao
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D016009:Chi-Square Distribution; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis*; D012307:Risk Factors; D046888:Tissue Array Analysis; D019014:fas Receptor / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; C491901:FAS protein, human; C489427:MYC protein, human; D016271:Proto-Oncogene Proteins c-myc; D019014:fas Receptor
keywords: Fas (CD95/APO1); Pancreatic cancer; c-Myc; immunohistochemistry; survival analysis