title: Constant high adrenal FDG uptake in PET/CT associated with mitochondrial disease.
abstract: We describe a patient with the m.3243A>G mitochondrial DNA mutation who developed sepsis caused by Streptococcus constellatus. In the acute phase of illness, abnormally high uptake of (18)F-FDG was observed in both adrenal glands that appeared anatomically normal. In repeated imaging six months later the adrenal uptake had diminished but remained clearly elevated. We did not observe high adrenal FDG uptake as in the patient described here among 30 patients with Staphylococcus aureus sepsis that were investigated with identical imaging protocol. In sepsis, oxygen consumption and metabolic rate are increased compared to normal metabolism. The observed high adrenal FDG uptake during sepsis in this patient probably reflects the acute metabolic stress induced by the infection. Interestingly, in repeated imaging six months later, the adrenal SUVs had diminished but were still abnormally high: this suggests constant high levels of metabolic stress associated with the mitochondrial disorder.
authors.affiliation: Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520, Turku, Finland, mikmar@utu.fi.
authors.forename: Mika H
authors.initials: MH
authors.lastname: Martikainen
authors.forename: Ulla
authors.initials: U
authors.lastname: Hohenthal
authors.forename: Laura
authors.initials: L
authors.lastname: Pirilä
authors.forename: Jukka
authors.initials: J
authors.lastname: Kemppainen
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging*; D004272:DNA, Mitochondrial / Q000235:genetics; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008875:Middle Aged; D028361:Mitochondrial Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D018805:Sepsis / Q000000981:diagnostic imaging; D013290:Streptococcal Infections / Q000000981:diagnostic imaging; D034365:Streptococcus constellatus
chemical_list: D004272:DNA, Mitochondrial; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18