title: [Macular and retinal nerve fiber layer thickness in myopic children by three-dimensional OCT].
abstract: OBJECTIVE
  To investigate the variations of macular thickness and peripapillary retinal nerve fiber layer (RNFL) thickness in myopic children.
  
  
  METHODS
  A total of 96 eyes from 48 myopic children at department of Ophthalmology, Second Affiliated Hospital of Wenzhou Medical College from September 2010 to March 2012 were enrolled in this study and divided into three groups (low, moderate and high myopia group) according to the severity of myopia. Another 33 eyes from 19 emmetropic children were recruited as control group. The macular thickness and peripapillary RNFL thickness of the myopic children measured by optical coherence tomography were compared with that of the control group.
  
  
  RESULTS
  The mean thickness of nasal, superior and inferior regions of outer-ring macular in the high myopia group were 276 µm, 294 µm, 285 µm respectively, which were significantly lower than that in the control group (P < 0.05). The mean thickness of superior of outer-ring macular in the low and moderate groups were 302 µm, 301 µm respectively, and the inferior of outer-ring ones were 288 µm, 283 µm respectively, which were significantly lower than that in the control group (P < 0.05). The temporal region of peripapillary RNFL thickness was significantly greater, and the other six regions of RNFL thicknesses were significantly lower in the high group than in the control group (P < 0.05). The central-1 mm, superior region of inner-ring, temporal and superior region of outer-ring macular thickness had positive correlations with spherical equivalent (SE) (P < 0.05). There was a negative correlation between the temporal peripapillary RNFL thickness and SE, while positive correlations were found between other regions of peripapillary RNFL thickness and SE (P < 0.05).
  
  
  CONCLUSIONS
  The thicknesses of macular and peripapillary RNFL of myopic children have already redistributed before apparent changes of funds.
authors.affiliation: Department of Ophthalmology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China.
authors.forename: Zhe-ren
authors.initials: ZR
authors.lastname: Xia
authors.forename: Jing-lu
authors.initials: JL
authors.lastname: Ying
authors.forename: Jia
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Email:doctorlily@hotmail.com.
authors.forename: Sui-lian
authors.initials: SL
authors.lastname: Zheng
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008266:Macula Lutea / Q000000981:diagnostic imaging*; D008297:Male; D009216:Myopia / Q000000981:diagnostic imaging*; D009898:Optic Disk; D011859:Radiography; D012160:Retina / Q000000981:diagnostic imaging*; D041623:Tomography, Optical Coherence / Q000379:methods*