title: Deregulation of cell signaling in cancer.
abstract: Oncogenic mutations disrupt the regulatory circuits that govern cell function, enabling tumor cells to undergo de-regulated mitogenesis, to resist to pro-apoptotic insults, and to invade through tissue boundaries. Cancer cell biology has played a crucial role in elucidating the signaling mechanisms by which oncogenic mutations sustain these malignant behaviors and thereby in identifying rational targets for cancer drugs. The efficacy of such targeted therapies illustrate the power of a reductionist approach to the study of cancer.
authors.affiliation: Cell Biology Program, Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, New York, NY, United States. Electronic address: F-Giancotti@ski.mskcc.org.
authors.forename: Filippo G
authors.initials: FG
authors.lastname: Giancotti
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000473:pathology; D015398:Signal Transduction
keywords: Cancer cell biology; Cell signaling; Targeted therapies; Tumorigenesis