title: The mckittrick-wheelock syndrome: a rare cause of severe hydroelectrolyte disorders and acute renal failure.
abstract: The McKittrick-Wheelock syndrome is a rare cause of severe hydroelectrolyte disorders and fluid depletion as a result of rectal tumor hypersecretion, which can lead to acute renal failure. We report the case of a 70-year-old female who presented with hyponatremia, hypokalemia, hypochloremia, and acute renal failure, due to a watery, mucinous diarrhea. A large rectal villous adenoma was discovered on ileocolonoscopy, and definitive management was achieved by removal of the tumor. In conclusion, reversal of the biochemical derangement is the cornerstone of successful management of the McKittrick-Wheelock syndrome. Then, immediate surgical resection of the tumor is the treatment of choice.
authors.affiliation: Division of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bruno
authors.affiliation: Division of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Chimienti
authors.affiliation: Division of Surgery, Miulli General Hospital, 70021 Acquaviva delle Fonti, Italy.
authors.forename: Alda
authors.initials: A
authors.lastname: Montanaro
authors.affiliation: Division of Surgery, Miulli General Hospital, 70021 Acquaviva delle Fonti, Italy.
authors.forename: Fernando
authors.initials: F
authors.lastname: Prete
authors.affiliation: Division of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, Italy.
authors.forename: Pasquale
authors.initials: P
authors.lastname: Libutti
authors.affiliation: Division of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, Italy.
authors.forename: Piero
authors.initials: P
authors.lastname: Lisi
authors.affiliation: Division of Nephrology, Miulli General Hospital, 70021 Acquaviva delle Fonti, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Basile