title: TRPM2: a multifunctional ion channel for oxidative stress sensing.
abstract: Transient receptor potential (TRP) superfamily is a superfamily of cation channels that can be divided into seven subfamilies. TRPM2 is the second member of the TRPM subfamily, which includes eight members, namely TRPM1-8. TRPM2 is widely expressed in excitable and non-excitable cells, where it forms a Ca(2+)-permeable cation channel and performs diverse cellular functions. TRPM2 channels are activated by ADP-ribose (ADPR), Ca(2+), H2O2 and other reactive oxygen species (ROS). It is established that TRPM2 serves as a cellular sensor for oxidative stress, mediating oxidative stress-induced [Ca(2+)]i increase and contributing to pathological processes in many cell types. Accumulating evidence has indicated that TRPM2 is a potential therapeutic target for oxidative stress-related diseases. This review will highlight recent progress in this field.
authors.affiliation: Shenzhen Research Institute and School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China. ruxiaochen2013@gmail.com.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Ru
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Yao
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000502:physiology; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism; D050053:TRPM Cation Channels / Q000502:physiology*
chemical_list: D015220:Calcium Channels; D017382:Reactive Oxygen Species; D050053:TRPM Cation Channels; C121934:TRPM2 protein, human; D000246:Adenosine Diphosphate Ribose; D006861:Hydrogen Peroxide; D002118:Calcium