title: [Current results on PSA-based prostate cancer detection].
abstract: Prostate cancer is the most common cancer and the third leading cause of cancer-specific death in men in Western industrialized countries. Implementation of the prostate-specific antigen (PSA) blood test as an early detection tool has led to a significant reduction of prostate cancer mortality in the USA. Apart from an earlier detection of clinically relevant tumors, regular PSA testing increases the risk of over-detection and over-treatment of clinically indolent tumors. In our view, a reliable stratification of indolent tumors in active surveillance programs is the key in avoiding or reducing overtreatment of early diagnosed prostate cancers. Along with better risk stratification, the expansion of PSA screening should be discussed in order to reduce the still high numbers of palliative treatments, metastases, and prostate cancer-related deaths.
authors.affiliation: Martini-Klinik, Prostatakarzinomzentrum am UKE, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.
authors.forename: M
authors.initials: M
authors.lastname: Graefen
authors.forename: T
authors.initials: T
authors.lastname: Schlomm
authors.forename: T
authors.initials: T
authors.lastname: Steuber
authors.forename: G
authors.initials: G
authors.lastname: Sauter
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D003951:Diagnostic Errors / Q000517:prevention & control / Q000706:statistics & numerical data*; D055088:Early Detection of Cancer / Q000379:methods / Q000706:statistics & numerical data*; D019317:Evidence-Based Medicine; D006801:Humans; D008297:Male; D015995:Prevalence; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis* / Q000453:epidemiology; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen
vernacular_title: Aktuelle Ergebnisse zur PSA-basierten Früherkennung des Prostatakarzinoms.