title: Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline.
abstract: We describe the case of a 63-year-old female who presented with severe inflammatory spondylitis, refractory to various antibiotics. Mycobacterial and fungal osteomyelitis were unlikely. Although asymptomatic, she also had osteomyelitis in the sternocostoclavicular region, and was suspected of having synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome, against which minocycline showed marked efficacy. The presence of severe inflammatory SAPHO, albeit rare, together with the marked efficacy of tetracycline, should be noted.
authors.affiliation: Department of Allergy and Immunological Diseases, Tokyo Metropolitan Komagome Hospital , Tokyo , Japan.
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Takizawa
authors.forename: Atsuko
authors.initials: A
authors.lastname: Murota
authors.forename: Keigo
authors.initials: K
authors.lastname: Setoguchi
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000150:complications / Q000188:drug therapy*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D008911:Minocycline
keywords: Propionibacterium acnes; SAPHO; Tetracycline