title: [Extrapolation of physiopathological data to clinical practice: Example of dabigatran in off-label use].
authors.affiliation: Faculté de médecine, laboratoire de pharmacologie médicale et clinique, équipe de pharmaco-épidémiologie de l'Inserm U1027, 31000 Toulouse, France. Electronic address: alicia.molinier@gmail.com.
authors.forename: Alicia
authors.initials: A
authors.lastname: Molinier
authors.affiliation: CHU de Toulouse, hôpital Purpan, service de neurologie, 31300 Toulouse, France.
authors.forename: Blandine
authors.initials: B
authors.lastname: Acket
authors.affiliation: Direction régionale du service médical Midi-Pyrénées (CNAMTS), 31000 Toulouse, France.
authors.forename: Robert
authors.initials: R
authors.lastname: Bourrel
authors.affiliation: CRCV Bois-Gibert, 37510 Ballan Miré, France.
authors.forename: Orso
authors.initials: O
authors.lastname: Lavezzi
authors.affiliation: Faculté de médecine, laboratoire de pharmacologie médicale et clinique, équipe de pharmaco-épidémiologie de l'Inserm U1027, 31000 Toulouse, France.
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Montastruc
authors.affiliation: Faculté de médecine, laboratoire de pharmacologie médicale et clinique, équipe de pharmaco-épidémiologie de l'Inserm U1027, 31000 Toulouse, France.
authors.forename: Haleh
authors.initials: H
authors.lastname: Bagheri
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000991:Antithrombins / Q000009:adverse effects / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000009:adverse effects / Q000627:therapeutic use*; D000075202:Contraindications; D000069604:Dabigatran; D057915:Drug Substitution; D057239:Early Termination of Clinical Trials; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D009203:Myocardial Infarction / Q000139:chemically induced; D056687:Off-Label Use; D011183:Postoperative Complications / Q000503:physiopathology* / Q000517:prevention & control*; D011725:Pyridines / Q000009:adverse effects / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000503:physiopathology* / Q000517:prevention & control*; D013923:Thromboembolism / Q000503:physiopathology* / Q000517:prevention & control*; D014812:Vitamin K / Q000037:antagonists & inhibitors; D015091:beta-Alanine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000991:Antithrombins; D001562:Benzimidazoles; D011725:Pyridines; D015091:beta-Alanine; D014812:Vitamin K; D000069604:Dabigatran
vernacular_title: Extrapolation des données physiopathologiques à la pratique clinique : à propos du dabigatran utilisé hors AMM.