title: Four new eudesmane-type sesquiterpenes from the basal leaves of Salvia plebeia R. Br.
abstract: Four new eudesmane-type sesquiterpenes, named plebeiolide A-C (1-3) and plebeiafuran (4), together with a known eudesmanolide (5), were isolated from the basal leaves of Salvia plebeia R. Br. Their structures were elucidated by extensive spectroscopic analysis including 1D and 2D NMR, HR-ESI-MS spectra. The absolute configuration of compound 1 was confirmed by single-crystal X-ray analysis and CD spectra. The inhibitory activity of isolated compounds toward NO production in lipopolysaccharide-induced RAW264.7 cells was evaluated and compounds 3 and 4 showed moderate inhibitory activity. In addition, the sesquiterpene lactones in Lamiaceae plants may possess some chemosystematic implications at intergeneric and intrageneric levels.
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Yiqun
authors.initials: Y
authors.lastname: Dai
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Guoyong
authors.initials: G
authors.lastname: Xie
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Qin
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. Electronic address: minjianqin@163.com.
authors.forename: Minjian
authors.initials: M
authors.lastname: Qin
mesh_terms: D000818:Animals; D002460:Cell Line; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry*; D027544:Salvia / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D007783:Lactones; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; C000594066:plebeiafuran; C000594063:plebeiolide; D009569:Nitric Oxide; C015872:eudesmane
keywords: Chemosystematic implication; Eudesmane; Inhibitory activity on NO production; Lamiaceae; Salvia plebeia; Sesquiterpene