title: Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation.
abstract: A biologically inspired thermoresponsive polymer has been developed that mechanically induces tooth differentiation in vitro and in vivo by promoting mesenchymal cell compaction as seen in each pore of the scaffold. This normally occurs during the physiological mesenchymal condensation response that triggers tooth formation in the embryo.
authors.affiliation: Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA; Harvard School of Engineering and Applied Sciences, Cambridge, MA, 02138, USA.
authors.forename: Basma
authors.initials: B
authors.lastname: Hashmi
authors.forename: Lauren D
authors.initials: LD
authors.lastname: Zarzar
authors.forename: Tadanori
authors.initials: T
authors.lastname: Mammoto
authors.forename: Akiko
authors.initials: A
authors.lastname: Mammoto
authors.forename: Amanda
authors.initials: A
authors.lastname: Jiang
authors.forename: Joanna
authors.initials: J
authors.lastname: Aizenberg
authors.forename: Donald E
authors.initials: DE
authors.lastname: Ingber
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D040761:Biomimetic Materials / Q000737:chemistry*; D055415:Bone Morphogenetic Protein 4 / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology*; D020100:Hydrogels / Q000737:chemistry; D007668:Kidney / Q000502:physiology / Q000601:surgery; D051957:MSX1 Transcription Factor / Q000378:metabolism; D059630:Mesenchymal Stem Cells / Q000502:physiology*; D051379:Mice; D009842:Oligopeptides / Q000737:chemistry; D051764:PAX9 Transcription Factor; D051761:Paired Box Transcription Factors / Q000378:metabolism; D016062:Porosity; D013696:Temperature; D054457:Tissue Scaffolds / Q000737:chemistry*; D014070:Tooth / Q000502:physiology
chemical_list: D000180:Acrylic Resins; D001672:Biocompatible Materials; C525810:Bmp4 protein, mouse; D055415:Bone Morphogenetic Protein 4; D020100:Hydrogels; D051957:MSX1 Transcription Factor; C484084:Msx1 protein, mouse; D009842:Oligopeptides; D051764:PAX9 Transcription Factor; D051761:Paired Box Transcription Factors; C488759:Pax9 protein, mouse; C052970:poly-N-isopropylacrylamide; C049554:glycyl-arginyl-glycyl-aspartyl-serine
keywords: biomaterials; odontogenesis; poly(N-isopropylacrylamide); scaffold engineering; thermoresponsive