title: Noncanonical autophagy: one small step for LC3, one giant leap for immunity.
abstract: Noncanonical autophagy is utilized by phagocytes to kill and digest extracellular pathogens. This process is initiated at the cell surface by receptors that recruit elements of the autophagy machinery, like LC3, to the phagosome. Also known as LC3-associated phagocytosis, the intersection of autophagy and phagocytosis was initially described as a pathway that limits the proliferation of engulfed pathogens by expediting phagosome maturation. Emerging evidences suggest that this pathway confers previously unsuspected versatility to the immune response as it regulates functions like the interferon pathway, dead cell clearance, and antigen presentation. Here we review recent advances in understanding the functional consequences of linking the autophagy machinery to phagocytosis in innate immunity.
authors.affiliation: RIA, Research Department, MedImmune, Gaithersburg, MD 20878, USA.
authors.forename: Payal
authors.initials: P
authors.lastname: Mehta
authors.affiliation: RIA, Research Department, MedImmune, Gaithersburg, MD 20878, USA.
authors.forename: Jill
authors.initials: J
authors.lastname: Henault
authors.affiliation: RIA, Research Department, MedImmune, Gaithersburg, MD 20878, USA.
authors.forename: Roland
authors.initials: R
authors.lastname: Kolbeck
authors.affiliation: RIA, Research Department, MedImmune, Gaithersburg, MD 20878, USA. Electronic address: sanjuanm@medimmune.com.
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sanjuan
mesh_terms: D000818:Animals; D001343:Autophagy / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology; D007425:Intracellular Membranes / Q000276:immunology / Q000378:metabolism; D008247:Lysosomes / Q000276:immunology / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D010588:Phagosomes / Q000276:immunology* / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors / Q000502:physiology
chemical_list: D018836:Inflammation Mediators; C477012:MAP1LC3A protein, human; C480860:Map1lc3b protein, mouse; D008869:Microtubule-Associated Proteins; D051193:Toll-Like Receptors