title: A clinical score, including biohumoral parameters, is a useful pretest index to discriminate pulmonary infections from radiation damage in chemoradiation-treated lung cancer patients.
abstract: To obtain an easy and prompt differential diagnosis between lower airways infections and acute radiation pneumonitis in chemoradiation lung cancer patients. From 303 patients treated, only patients with severe pulmonary symptoms were hospitalized. Clinical and radiation scores were calculated evaluating clinical, biohumoral, dosimetric parameters. Out of 36 patients hospitalized, infections and acute radiation pneumonitis were reported in 66.7% and 33.3%, respectively. Patients with clinical score ≥ 2 had an Odds Ratio of 3.4 (1.4-8.3; p = .006) to have infectious pneumonia, while radiation score was not predictive.
authors.affiliation: Department of Radiation Oncology,1.
authors.forename: Sara
authors.initials: S
authors.lastname: Ramella
authors.forename: Silvia
authors.initials: S
authors.lastname: Spoto
authors.forename: Michele
authors.initials: M
authors.lastname: Fiore
authors.forename: Giovanna
authors.initials: G
authors.lastname: Grasso
authors.forename: Roberto Erasmo
authors.initials: RE
authors.lastname: Campanale
authors.forename: Edy
authors.initials: E
authors.lastname: Ippolito
authors.forename: Carlo
authors.initials: C
authors.lastname: Greco
authors.forename: Aurelia
authors.initials: A
authors.lastname: Iurato
authors.forename: Luca Eolo
authors.initials: LE
authors.lastname: Trodella
authors.forename: Marco
authors.initials: M
authors.lastname: Cortigiani
authors.forename: Lucio
authors.initials: L
authors.lastname: Trodella
authors.forename: Rolando Maria
authors.initials: RM
authors.lastname: D'Angelillo
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Costantino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001419:Bacteria / Q000302:isolation & purification; D015415:Biomarkers / Q000097:blood; D059248:Chemoradiotherapy / Q000009:adverse effects*; D016009:Chi-Square Distribution; D003937:Diagnosis, Differential; D005260:Female; D006760:Hospitalization; D006801:Humans; D008175:Lung Neoplasms / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011829:Radiation Dosage; D017564:Radiation Pneumonitis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D012141:Respiratory Tract Infections / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers