title: A new molecule in aneurysmal subarachnoid hemorrhage: dendroaspis natriuretic peptide.
abstract: OBJECTIVE
  Dendroaspis natriuretic peptide (DNP) is the most recently identified member of the natriuretic peptide family. Although DNP has similar structure and function to other members, it is genetically different. The other members are known to cause vasorelaxation but the effects of DNP on vascular structure still remains unclear. In this study, we aimed to find out the role of DNP in the development of vasospasm following aneurysmal SAH (subarachnoid hemorrhage).
  
  
  METHODS
  DNP levels of 17 patients diagnosed with aneurysmal SAH and 25 volunteers as control were measured. All SAH patients were treated with aneurysm clip. Five ml of venous blood sample was obtained on postoperative 1, 3 and 7th days from each patient. Additionally, DNP levels were determined by obtaining cerebrospinal fluid (CSF) postoperative 1, 3 and 7th days.
  
  
  RESULTS
  Statistically significant difference was observed between cerebrospinal fluid DNP levels on day 1 and day 3 (P < 0.05).
  
  
  CONCLUSIONS
  This study suggests that DNP can be anticipated among molecules leading development of vasospasm. The findings of present study are believed to encourage further studies regarding receptors and receptor specific drugs.
authors.affiliation: West Bahat Hospital, Department of Neurosurgery, Istanbul, Turkey.
authors.forename: Alpay
authors.initials: A
authors.lastname: Serefhan
authors.forename: Murat
authors.initials: M
authors.lastname: Altas
authors.forename: Ajlan
authors.initials: A
authors.lastname: Cerci
authors.forename: Nejat
authors.initials: N
authors.lastname: Isik
authors.forename: Ilhan
authors.initials: I
authors.lastname: Elmaci
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004546:Elapid Venoms / Q000134:cerebrospinal fluid / Q000235:genetics*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000134:cerebrospinal fluid / Q000235:genetics*; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging / Q000235:genetics*; D017585:Ultrasonography, Doppler, Transcranial; D020301:Vasospasm, Intracranial / Q000209:etiology; D055815:Young Adult
chemical_list: C075597:Dendroaspis natriuretic peptide; D004546:Elapid Venoms; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides