title: Wheezing phenotypes in young children: an historical cohort study.
abstract: BACKGROUND
  Wheezing phenotypes in young children have usually been described on the basis of questionnaire surveys instead of prospectively doctor-diagnosed episodes, and have never been described in terms of incidence rates.
  
  
  OBJECTIVE
  To identify wheezing phenotypes in the first three years and describe their incidence trends, and to investigate their relationship with asthma at six years of age.
  
  
  METHODS
  Doctor-diagnosed wheezing episodes in the first 36 months and active asthma at six years were identified in a historical cohort of 3,739 children followed from birth in 29 primary care health centres in Spain. Wheezing phenotypes were identified by means of latent class analysis. Changes in incidence rates of wheezing were identified through joinpoint regression models and their predictive ability for asthma was analysed.
  
  
  RESULTS
  One never/infrequent wheeze phenotype and three wheezing phenotypes were identified. There were two early phenotypes which started wheezing at a median age of six months, one of which was transient while the other had a heavy recurrence of episodes. A third phenotype exhibited a delayed onset of wheezing, a constant rise in incidence through the first 36 months, and a relationship with allergic asthma. These three phenotypes had a higher prevalence of active asthma at six years than the never/infrequent wheeze phenotype, but the classification had a weak predictive ability for asthma due to low sensitivity.
  
  
  CONCLUSIONS
  The use of incidence rates contributes to the clarification of the natural history of infant wheezing.
authors.affiliation: Villamuriel Primary Care Health Centre, Regional Health Service, Castilla y León, Spain.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Cano-Garcinuño
authors.forename: Isabel
authors.initials: I
authors.lastname: Mora-Gandarillas
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000235:genetics; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D010641:Phenotype; D012135:Respiratory Sounds / Q000235:genetics*