title: Gold nanoparticles in breast cancer treatment: promise and potential pitfalls.
abstract: Despite remarkable achievements in the treatment of breast cancer, some obstacles still remain. Gold nanoparticles may prove valuable in addressing these problems owing to their unique characteristics, including their enhanced permeability and retention in tumor tissue, their light absorbance and surface plasmon resonance in near-infrared light, their interaction with radiation to generate secondary electrons, and their ability to be conjugated with drugs or other agents. Herein, we discuss some basic concepts of gold nanoparticles, and early results from studies regarding their use in breast cancer, including toxicity and side effects. We also discuss these particles' potential clinical applications.
authors.affiliation: Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA; Department of Surgery, Soon Chun Hyang University Hospital, 657 Hannam-dong, Yongsangu, Seoul 140-743, Republic of Korea.
authors.forename: Jihyoun
authors.initials: J
authors.lastname: Lee
authors.affiliation: Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA.
authors.forename: Dev Kumar
authors.initials: DK
authors.lastname: Chatterjee
authors.affiliation: Department of Surgery, Soon Chun Hyang University Hospital, 657 Hannam-dong, Yongsangu, Seoul 140-743, Republic of Korea.
authors.forename: Min Hyuk
authors.initials: MH
authors.lastname: Lee
authors.affiliation: Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA. Electronic address: SKrishnan@mdanderson.org.
authors.forename: Sunil
authors.initials: S
authors.lastname: Krishnan
mesh_terms: D001943:Breast Neoplasms / Q000628:therapy*; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D006979:Hyperthermia, Induced; D053768:Metal Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use
chemical_list: D011838:Radiation-Sensitizing Agents; D006046:Gold
keywords: Breast neoplasms; Gold nanoparticle; Nanotechnology; Theranostics