title: The life of plant mitochondrial complex I.
abstract: The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA editing, trans-splicing), (iii) its assembly follows unique routes, (iv) it includes an additional functional domain which contains carbonic anhydrases and (v) it is, indirectly, involved in photosynthesis. Comprising about 50 distinct protein subunits, complex I of plants is very large. However, an even larger number of proteins are required to synthesize these subunits and assemble the enzyme complex. This review aims to follow the complete "life cycle" of plant complex I from various molecular perspectives. We provide arguments that complex I represents an ideal model system for studying the interplay of respiration and photosynthesis, the cooperation of mitochondria and the nucleus during organelle biogenesis and the evolution of the mitochondrial oxidative phosphorylation system.
authors.affiliation: Institut für Pflanzengenetik, Leibniz Universität Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany. Electronic address: braun@genetik.uni-hannover.de.
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Braun
authors.affiliation: Molekulare Botanik, Universität Ulm, Albert-Einstein-Allee 11, 89069 Ulm, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Binder
authors.affiliation: Molekulare Botanik, Universität Ulm, Albert-Einstein-Allee 11, 89069 Ulm, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Brennicke
authors.affiliation: Institut für Pflanzengenetik, Leibniz Universität Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany.
authors.forename: Holger
authors.initials: H
authors.lastname: Eubel
authors.affiliation: Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam, Germany.
authors.forename: Alisdair R
authors.initials: AR
authors.lastname: Fernie
authors.affiliation: Plant Sciences, Ludwig Maximilians Universität München, Grosshadernerstr. 2-4, 82152 Planegg-Martinsried, Germany.
authors.forename: Iris
authors.initials: I
authors.lastname: Finkemeier
authors.affiliation: Institut für Pflanzengenetik, Leibniz Universität Hannover, Herrenhäuser Str. 2, 30419 Hannover, Germany.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Klodmann
authors.affiliation: Plant Sciences, Ludwig Maximilians Universität München, Grosshadernerstr. 2-4, 82152 Planegg-Martinsried, Germany.
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: König
authors.affiliation: Institut für Biologie/Molekulare Zellbiologie der Pflanzen, Humboldt Universität zu Berlin, Philippstraße 13, 10115 Berlin, Germany.
authors.forename: Kristina
authors.initials: K
authors.lastname: Kühn
authors.affiliation: Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam, Germany.
authors.forename: Etienne
authors.initials: E
authors.lastname: Meyer
authors.affiliation: Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam, Germany.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Obata
authors.affiliation: INRES - Chemical Signalling, Rheinische Friedrich-Wilhelms-Universität Bonn, Friedrich-Ebert-Allee 144, D-53113 Bonn, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Schwarzländer
authors.affiliation: Molekulare Botanik, Universität Ulm, Albert-Einstein-Allee 11, 89069 Ulm, Germany.
authors.forename: Mizuki
authors.initials: M
authors.lastname: Takenaka
authors.affiliation: Molekulare Botanik, Universität Ulm, Albert-Einstein-Allee 11, 89069 Ulm, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Zehrmann
mesh_terms: D042967:Electron Transport Complex I / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism; D055503:Protein Multimerization; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism
chemical_list: D021122:Protein Subunits; D042967:Electron Transport Complex I
keywords: Carbonic anhydrase; Oxidative phosphorylation; Oxidoreductase; Plant mitochondria; RNA editing; Reactive oxygen species