title: Are there meaningful biomarkers of treatment response for depression?
abstract: During the past decades, the prevalence of affective disorders has been on the rise globally, with only one out of three patients achieving remission in acute treatment with antidepressants. The identification of physiological markers that predict treatment course proves useful in increasing therapeutic success. On the basis of well-documented, recent findings in depression research, we highlight and discuss the most promising biomarkers for antidepressant therapy response. These include genetic variants and gene expression profiles, proteomic and metabolomic markers, neuroendocrine function tests, electrophysiology and imaging techniques. Ultimately, this review proposes an integrative use of biomarkers for antidepressant treatment outcome.
authors.affiliation: HolsboerMaschmeyerNeuroChemie, Munich, Germany; Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Barbara
authors.initials: B
authors.lastname: Breitenstein
authors.affiliation: Max Planck Institute of Psychiatry, Munich, Germany.
authors.forename: Sandra
authors.initials: S
authors.lastname: Scheuer
authors.affiliation: HolsboerMaschmeyerNeuroChemie, Munich, Germany; Max Planck Institute of Psychiatry, Munich, Germany. Electronic address: holsboer@mpipsykl.mpg.de.
authors.forename: Florian
authors.initials: F
authors.lastname: Holsboer
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism; D003863:Depression / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D015415:Biomarkers; D005819:Genetic Markers