title: Role of calprotectin in cardiometabolic diseases.
abstract: Calprotectin represents an interesting peptide known to be involved in the pathophysiology of various inflammatory processes. Being secreted from activated neutrophils and monocytes under various conditions, it can also be found in the extracellular fluids and serve as a biomarker of ongoing inflammation, which property is currently used in the monitoring of inflammatory bowel diseases. Recent studies, however, suggest that calprotectin could serve as an important prognostic factor for cardiovascular and cardiometabolic diseases, since these are occurring on the basis of low-grade chronic inflammation. We assume that calprotectin may represent a useful marker in predicting the course of atherosclerotic process, coronary artery disease and acute coronary syndromes. Our review is focused on the importance of calprotectin in the diagnosis and prognostic stratification in the field of cardiometabolic risk.
authors.affiliation: Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne' University Hospital Brno, Brno, Czech Republic; Institute of Normal and Pathological Physiology and Centre of Excellence for Regulatory Role of Nitric Oxide in Civilisation Diseases, Slovak Academy of Sciences, Bratislava, Slovak Republic. Electronic address: peter.kruzliak@savba.sk.
authors.forename: Peter
authors.initials: P
authors.lastname: Kruzliak
authors.affiliation: Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne' University Hospital Brno, Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Pathological Physiology, Masaryk University, Brno, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Novák
authors.affiliation: Department of Cardiovascular Diseases, International Clinical Research Center, St. Anne' University Hospital Brno, Brno, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Novák
authors.affiliation: Head of Research, The Minto Prevention and Rehabilitation Centre, University of Ottawa Heart Institute, Ontario, Ottawa, Canada.
authors.forename: George J
authors.initials: GJ
authors.lastname: Fodor
mesh_terms: D054058:Acute Coronary Syndrome / Q000503:physiopathology; D050197:Atherosclerosis / Q000209:etiology; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000209:etiology / Q000503:physiopathology*; D003324:Coronary Artery Disease / Q000503:physiopathology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000503:physiopathology; D039841:Leukocyte L1 Antigen Complex / Q000502:physiology*; D011379:Prognosis; D012306:Risk
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex
keywords: Calprotectin; Cardiovascular diseases; Metabolic diseases; Myocardial infarction; Obesity