title: Intranasal administration of retinyl palmitate with a respiratory virus vaccine corrects impaired mucosal IgA response in the vitamin A-deficient host.
abstract: Our previous studies showed that intranasal vaccination of vitamin A-deficient (VAD) mice failed to induce normal levels of upper respiratory tract IgA, a first line of defense against respiratory virus infection. Here we demonstrate that the impaired responses in VAD animals are corrected by a single intranasal application of retinyl palmitate with the vaccine. Results encourage the clinical testing of intranasal vitamin A supplements to improve protection against respiratory viral disease in VAD populations.
authors.affiliation: Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
authors.forename: Sherri L
authors.initials: SL
authors.lastname: Surman
authors.forename: Bart G
authors.initials: BG
authors.lastname: Jones
authors.forename: Rajeev
authors.initials: R
authors.lastname: Rudraraju
authors.forename: Robert E
authors.initials: RE
authors.lastname: Sealy
authors.forename: Julia L
authors.initials: JL
authors.lastname: Hurwitz
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000281:Administration, Intranasal; D000818:Animals; D004224:Diterpenes; D005260:Female; D018928:Immunity, Mucosal; D007070:Immunoglobulin A / Q000276:immunology*; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D012137:Respiratory System / Q000276:immunology*; D000084562:Retinyl Esters; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives*; D014802:Vitamin A Deficiency / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D004224:Diterpenes; D007070:Immunoglobulin A; D000084562:Retinyl Esters; D014765:Viral Vaccines; D014801:Vitamin A; C014794:retinol palmitate