title: Multi-delay arterial spin labeling perfusion MRI in moyamoya disease--comparison with CT perfusion imaging.
abstract: OBJECTIVE
  To present a multi-delay pseudo-continuous ASL (pCASL) protocol that offers simultaneous measurements of cerebral blood flow (CBF) and arterial transit time (ATT), and to study correlations between multi-delay pCASL and CT perfusion in moyamoya disease.
  
  
  METHODS
  A 4 post-labeling delay (PLD) pCASL protocol was applied on 17 patients with moyamoya disease who also underwent CT perfusion imaging. ATT was estimated using the multi-delay protocol and included in the calculation of CBF. ASL and CT perfusion images were rated for lesion severity/conspicuity. Pearson correlation coefficients were calculated across voxels between the two modalities in grey and white matter of each subject respectively and between normalized mean values of ASL and CT perfusion measures in major vascular territories.
  
  
  RESULTS
  Significant associations between ASL and CT perfusion were detected using subjective ratings, voxel-wise analysis in grey and white matter and region of interest (ROI)-based analysis of normalized mean perfusion. The correlation between ASL CBF and CT perfusion was improved using the multi-delay pCASL protocol compared to CBF acquired at a single PLD of 2 s (P < 0.05).
  
  
  CONCLUSIONS
  There is a correlation between perfusion data from ASL and CT perfusion imaging in patients with moyamoya disease. Multi-delay ASL can improve CBF quantification, which could be a prognostic imaging biomarker in patients with moyamoya disease.
  
  
  CONCLUSIONS
  • Simultaneous measurements of CBF and ATT can be achieved using multi-delay pCASL. • Multi-delay ASL was compared with CT perfusion in patients with moyamoya disease. • Statistical analyses showed significant associations between multi-delay ASL and CT perfusion. • Multi-delay ASL can improve CBF quantification in moyamoya disease.
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing, 100101, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Songlin
authors.initials: S
authors.lastname: Yu
authors.forename: Jeffry R
authors.initials: JR
authors.lastname: Alger
authors.forename: Zhentao
authors.initials: Z
authors.lastname: Zuo
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: An
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Jizong
authors.initials: J
authors.lastname: Zhao
authors.forename: Rong
authors.initials: R
authors.lastname: Xue
authors.forename: Danny J J
authors.initials: DJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003097:Collateral Circulation; D003287:Contrast Media; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009072:Moyamoya Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D061330:Multidetector Computed Tomography; D009413:Nerve Fibers, Myelinated / Q000000981:diagnostic imaging; D055420:Perfusion Imaging; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D003287:Contrast Media