title: Mucoadhesive liposomes as new formulation for vaginal delivery of curcumin.
abstract: Local delivery to the affected area represents the optimal means by which advantageous pharmacological properties of curcumin may be fully exploited as currently, due to the biopharmaceutical limitations associated with this polyphenol, its full beneficial effects remain limited. Curcumin-containing liposomes coated with bioadhesive polymers of natural and synthetic origin (chitosan and Carbopol) were evaluated in vitro. For these purposes, an in vitro model of vaginal mucus was developed allowing the monitoring of curcumin permeability in the conditions mimicking vaginal environment. The model was optimized by varying the amounts of glycoproteins, as compared to the permeabilities determined through isolated bovine mucus. The strength of bioadhesion was evaluated using the isolated bovine mucosa. Both curcumin solution and non-coated curcumin liposomes served as controls. Bioadhesive polymers enabled significantly higher (p<0.05) curcumin permeability through the artificial and isolated bovine mucus compared to the controls. Polymer coating of liposomes resulted in an increase in their bioadhesiveness. Mucoadhesive liposomes can be considered as potential novel drug delivery systems intended for vaginal administration of curcumin.
authors.affiliation: Lek d.d., Ljubljana, Slovenia; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. Electronic address: katja.berginc@sandoz.com.
authors.forename: Katja
authors.initials: K
authors.lastname: Berginc
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Sabina
authors.initials: S
authors.lastname: Suljaković
authors.affiliation: Drug Transport and Delivery Research Group, Department of Pharmacy, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
authors.forename: Nataša
authors.initials: N
authors.lastname: Škalko-Basnet
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia.
authors.forename: Albin
authors.initials: A
authors.lastname: Kristl
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry* / Q000493:pharmacokinetics; D000268:Adhesiveness; D000282:Administration, Intravaginal; D000818:Animals; D002417:Cattle; D048271:Chitosan / Q000737:chemistry* / Q000493:pharmacokinetics; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics; D005260:Female; D066298:In Vitro Techniques; D008081:Liposomes; D009077:Mucins / Q000737:chemistry; D009092:Mucous Membrane / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D010539:Permeability; D013552:Swine; D014621:Vagina / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000180:Acrylic Resins; D004337:Drug Carriers; D008081:Liposomes; D009077:Mucins; C006912:carboxypolymethylene; D048271:Chitosan; D003474:Curcumin
keywords: Carbopol; Chitosan; Curcumin; Mucoadhesive liposomes; Vaginal delivery; in vitro model