title: Recovery of empathetic function following resection of insular gliomas.
abstract: The insular cortex is located deep within the Sylvian fissure between multi-functional and structurally-compressed cerebral structures, and has been suggested to play an important role in both basic sensorimotor and complex social-emotional functions. Such structural and functional complexity presents a challenge for neurosurgeons to remove tumors within the insula safely. It has therefore not yet been documented how neurosurgical resection of insular gliomas would impact social-emotional functions. In this study, we examined empathy, a high-level social-emotional function, in four patients with localized insular gliomas pre- and post-operatively. The patients completed an empathy-for others pain task in which they viewed another person's hand or foot in painful or non-painful situations and made judgments about either pain (explicit empathy) or laterality of the hand or foot (implicit empathy). They also completed questionnaires assessing general emotional processing and personality. Deficits in both explicit and implicit empathetic pain processing were found in patients before the operations. However, the operations significantly improved their empathetic ability after surgery, accompanied by unchanged personality traits. These results confirmed previous findings that the insula plays a critical role for empathetic pain perception. Importantly, the current results suggest that surgical resection is not only a suitable treatment for insular gliomas for clinical consideration, but also effective in improving high-level functions such as empathetic pain perception.
authors.affiliation: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
authors.forename: Xingchao
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaosi
authors.initials: X
authors.lastname: Gu
authors.forename: Jin
authors.initials: J
authors.lastname: Fan
authors.forename: Shiwei
authors.initials: S
authors.lastname: Wang
authors.forename: Fu
authors.initials: F
authors.lastname: Zhao
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Hof
authors.forename: Pinan
authors.initials: P
authors.lastname: Liu
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Gao
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000601:surgery*; D002540:Cerebral Cortex / Q000601:surgery*; D004645:Empathy; D005260:Female; D005910:Glioma / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D011795:Surveys and Questionnaires