title: Histological subtypes of lung cancer in Chinese males from 2000 to 2012.
abstract: OBJECTIVE
  To characterize the histological and epidemiological features of male lung cancer patients in China.
  
  
  METHODS
  The demographic and histological information about male lung cancer patients identified from 2000-01-01 to 2012-12-31, was collected from the Cancer Hospital of the Chinese Academy of Medical Sciences. Relative frequencies (RF) were estimated for major histological subtypes and compared according to the years of diagnosis and birth.
  
  
  RESULTS
  The RF of adenocarcinoma (ADC) increased from 21.96% to 43.36% and the RF of squamous cell carcinoma (SCC) decreased from 39.11% to 32.23% from 2000 to 2012 in the 15 427 male lung cancer patients included in this study (Z=17.909, P<0.0001; Z=-6.117, P<0.0001). The RF of ADC increased from 28.72% in 2000-2004, 36.88% in 2005-2008 to 48.61% in 2009-2012 in patients born after 1960. The age-adjusted RF of ADC in 2007-2012 increased consistently in all the investigated areas.
  
  
  CONCLUSIONS
  The increased RF of ADC in male lung cancer patients highlights the need for further investigation of the etiologic factors of these tumors. Smoke-free policies rather than modifying tobacco products should be enforced.
authors.affiliation: National Office of Cancer Prevention and Control, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Xiao Nong
authors.initials: XN
authors.lastname: Zou
authors.affiliation: Department of Pathology, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Dong Mei
authors.initials: DM
authors.lastname: Lin
authors.affiliation: Center for Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Wan
authors.affiliation: Center for Global Health, National Cancer Institute, Bethesda MD, USA.
authors.forename: Ann
authors.initials: A
authors.lastname: Chao
authors.affiliation: Department of Radiation Oncology, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Qin Fu
authors.initials: QF
authors.lastname: Feng
authors.affiliation: National Office of Cancer Prevention and Control, Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Dai
authors.affiliation: Center for Epidemiology and Biostatistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China.
authors.forename: Gong Huan
authors.initials: GH
authors.lastname: Yang
authors.affiliation: Department of Pathology, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Lv
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D002276:Carcinoid Tumor / Q000453:epidemiology* / Q000209:etiology; D018196:Carcinoma, Adenosquamous / Q000453:epidemiology* / Q000209:etiology; D002681:China / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification* / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects; D013997:Time Factors
keywords: Epidemiology; Histology; Lung cancer