title: DNA damage: RNA-binding proteins protect from near and far.
abstract: Recent work, including large-scale genetic and molecular analyses, identified RNA-binding proteins (RBPs) as major players in the prevention of genome instability. These studies show that RBPs prevent harmful RNA/DNA hybrids and are involved in the DNA damage response (DDR), from DNA repair to cell survival decisions. Indeed, specific RBPs allow the selective regulation of DDR genes at multiple post-transcriptional levels (from pre-mRNA splicing/polyadenylation to mRNA stability/translation) and are directly involved in DNA repair. These multiple activities are mediated by RBP binding to mRNAs, nascent transcripts, noncoding RNAs, and damaged DNA. Finally, because DNA damage modifies RBP localization and binding to different RNA/DNA molecules, we propose that upon DNA damage, RBPs coordinately regulate various aspects of both RNA and DNA metabolism.
authors.affiliation: Institut Curie, Centre de Recherche, Orsay, France; CNRS UMR3348, Genotoxic Stress and Cancer, Centre Universitaire, Orsay, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Dutertre
authors.affiliation: Institut Curie, Centre de Recherche, Orsay, France; CNRS UMR3348, Genotoxic Stress and Cancer, Centre Universitaire, Orsay, France.
authors.forename: Sarah
authors.initials: S
authors.lastname: Lambert
authors.affiliation: Institut Curie, Centre de Recherche, Orsay, France; CNRS UMR3348, Genotoxic Stress and Cancer, Centre Universitaire, Orsay, France.
authors.forename: Aura
authors.initials: A
authors.lastname: Carreira
authors.affiliation: Institut Curie, Centre de Recherche, Orsay, France; CNRS UMR3348, Genotoxic Stress and Cancer, Centre Universitaire, Orsay, France.
authors.forename: Mounira
authors.initials: M
authors.lastname: Amor-Guéret
authors.affiliation: Institut Curie, Centre de Recherche, Orsay, France; CNRS UMR3348, Genotoxic Stress and Cancer, Centre Universitaire, Orsay, France. Electronic address: stephan.vagner@curie.fr.
authors.forename: Stéphan
authors.initials: S
authors.lastname: Vagner
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism*; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D006801:Humans; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D016601:RNA-Binding Proteins; D012313:RNA; D004247:DNA
keywords: DNA damage response; RNA processing; mRNA translation; post-transcriptional control of gene expression