title: Implantation of pipeline flow-diverting stents reduces aneurysm inflow without relevantly affecting static intra-aneurysmal pressure.
abstract: BACKGROUND
  Flow-diverting stent (FDS) implantation is an endovascular treatment option for intracranial aneurysms. However, little is known about the hemodynamic effects.
  
  
  OBJECTIVE
  To assess the effect of stent compression on FDS porosity, to evaluate the influence of single and overlapping implantation of FDS on intra-aneurysmal flow profiles, and to correlate stent porosity with changes in static mean intra-aneurysmal pressure.
  
  
  METHODS
  Intra-aneurysmal time-density curves were recorded in a pulsatile in vitro flow model before and after implantation of FDSs (Pipeline Embolization Device; ev3) in 7 different types of aneurysm models. Reductions in the maximum contrast inflow and time to maximum intra-aneurysmal contrast were calculated. Micro--computed tomography was performed, and compression-related FDS porosity was measured. The influence of FDS placement on mean static intra-aneurysmal pressure was measured.
  
  
  RESULTS
  FDS compression resulted in an almost linear reduction in stent porosity. Stent porosity (struts per 1 mm) correlated significantly with the reduction of aneurysm contrast inflow (R = 0.81, P < .001) and delay until maximum contrast (R = 0.34, P = .001). Circulating intra-aneurysmal high-velocity flow was terminated in all sidewall models after implantation of a single stent. Superimposition of 2 stents reduced maximum intra-aneurysmal contrast by 69.1 ± 3.1% (mean ± SD) in narrow-necked sidewall aneurysm models, whereas no substantial reduction in maximum intra-aneurysmal contrast was observed in wide-necked sidewall aneurysm models. Intra-aneurysmal mean static pressure did not correlate with FDS porosity or number of implanted stents.
  
  
  CONCLUSIONS
  Implantation of FDS effectively reduces aneurysm inflow in a porosity-dependent way without relevantly affecting static mean intra-aneurysmal pressure.
  
  
  BACKGROUND
  FDS, flow-diverting stentMAP, mean arterial pressurePED, Pipeline Embolization Device.
authors.affiliation: *University of Heidelberg, Medical Faculty Mannheim, Department of Neuroradiology, Mannheim, Germany; ‡University Hospital of the RWTH Aachen, Department of Diagnostic and Interventional Neuroradiology, Aachen, Germany.
authors.forename: Hans U
authors.initials: HU
authors.lastname: Kerl
authors.forename: Hanne
authors.initials: H
authors.lastname: Boll
authors.forename: Teresa
authors.initials: T
authors.lastname: Fiebig
authors.forename: Giovanna
authors.initials: G
authors.lastname: Figueiredo
authors.forename: Alex
authors.initials: A
authors.lastname: Förster
authors.forename: Ingo S
authors.initials: IS
authors.lastname: Nölte
authors.forename: Andrea
authors.initials: A
authors.lastname: Nonn
authors.forename: Christoph
authors.initials: C
authors.lastname: Groden
authors.forename: Marc A
authors.initials: MA
authors.lastname: Brockmann
mesh_terms: D001783:Blood Flow Velocity; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods*; D002560:Cerebrovascular Circulation; D005260:Female; D006439:Hemodynamics; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D008297:Male; D008955:Models, Cardiovascular; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome