title: Multivariable adaptive identification and control for artificial pancreas systems.
abstract: A constrained weighted recursive least squares method is proposed to provide recursive models with guaranteed stability and better performance than models based on regular identification methods in predicting the variations of blood glucose concentration in patients with Type 1 Diabetes. Use of physiological information from a sports armband improves glucose concentration prediction and enables earlier recognition of the effects of physical activity on glucose concentration. Generalized predictive controllers (GPC) based on these recursive models are developed. The performance of GPC for artificial pancreas systems is illustrated by simulations with UVa-Padova simulator and clinical studies. The controllers developed are good candidates for artificial pancreas systems with no announcements from patients.
authors.forename: Kamuran
authors.initials: K
authors.lastname: Turksoy
authors.forename: Laurie
authors.initials: L
authors.lastname: Quinn
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Littlejohn
authors.forename: Ali
authors.initials: A
authors.lastname: Cinar
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000502:physiology; D002648:Child; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007332:Insulin Infusion Systems; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D015999:Multivariate Analysis; D019397:Pancreas, Artificial; D012815:Signal Processing, Computer-Assisted; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin