title: Does dexamethasone induce more neuropsychological side effects than prednisone in pediatric acute lymphoblastic leukemia? A systematic review.
abstract: Steroid-induced neuropsychological side effects impact quality of life in children with acute lymphoblastic leukemia. Dexamethasone induces more metabolic side effects than prednisone. To evaluate whether dexamethasone also leads to more neuropsychological side effects, we reviewed all available literature. Randomized controlled trials with neuropsychological function as the primary or secondary outcome did not show clinically meaningful differences between dexamethasone and prednisone on cognition, mood or behavior.
authors.affiliation: Department of Pediatric Hematology and Oncology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands; Department of Pediatric Endocrinology, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: L T
authors.initials: LT
authors.lastname: Warris
authors.forename: M M
authors.initials: MM
authors.lastname: van den Heuvel-Eibrink
authors.forename: M A H
authors.initials: MA
authors.lastname: den Hoed
authors.forename: F K
authors.initials: FK
authors.lastname: Aarsen
authors.forename: R
authors.initials: R
authors.lastname: Pieters
authors.forename: E L T
authors.initials: EL
authors.lastname: van den Akker
mesh_terms: D000293:Adolescent; D000339:Affect / Q000187:drug effects*; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects* / Q000627:therapeutic use; D001519:Behavior / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000187:drug effects*; D003907:Dexamethasone / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000523:psychology; D016032:Randomized Controlled Trials as Topic
chemical_list: D018931:Antineoplastic Agents, Hormonal; D003907:Dexamethasone
keywords: acute lymphoblastic leukemia; corticosteroids; neuropsychological; pediatrics; psychological