title: Invasive fungal diseases during first induction chemotherapy affect complete remission achievement and long-term survival of patients with acute myeloid leukemia.
abstract: We retrospectively evaluated, in a logistic-regression-model, the role of proven/probable invasive fungal diseases (PP-IFD), occurring during first induction chemotherapy, on the achievement of complete remission (CR) and overall survival (OS) in 198 acute myeloid leukemia (AML) patients. A PP-IFD was documented in 34 (17.2%) patients. Younger age, good performance status at AML diagnosis and no development of a PP-IFD (OR 4.09, 95% CI 1.71-9.81, p<0.0001) were independent factors associated to CR achievement. Younger age, good performance status, favorable genetic risk and no development of PP-IFD (HR 1.86, 95% CI 1.20-2.88, p=0.005) were independent factors associated to OS at 3 years.
authors.affiliation: Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy. Electronic address: girmenia@bce.uniroma1.it.
authors.forename: Corrado
authors.initials: C
authors.lastname: Girmenia
authors.affiliation: Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Micozzi
authors.affiliation: Fondazione GIMEMA (Gruppo Italiano Malattie EMatologiche dell'Adulto), Rome, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Piciocchi
authors.affiliation: Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gentile
authors.affiliation: Ematologia, Dipartimento di Biomedicina e Prevenzione, Università Tor Vergata, Rome, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Di Caprio
authors.affiliation: Ematologia, Dipartimento di Biomedicina e Prevenzione, Università Tor Vergata, Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Nasso
authors.affiliation: Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
authors.forename: Clara
authors.initials: C
authors.lastname: Minotti
authors.affiliation: Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
authors.forename: Saveria
authors.initials: S
authors.lastname: Capria
authors.affiliation: Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Cartoni
authors.affiliation: Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
authors.forename: Giuliana
authors.initials: G
authors.lastname: Alimena
authors.affiliation: Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Meloni
authors.affiliation: Ematologia, Dipartimento di Biomedicina e Prevenzione, Università Tor Vergata, Rome, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Amadori
authors.affiliation: Ematologia, Dipartimento di Ematologia, Oncologia, Anatomia Patologica e Medicina Rigenerativa, Azienda Policlinico Umberto I, "Sapienza" University of Rome, Italy.
authors.forename: Robin
authors.initials: R
authors.lastname: Foà
authors.affiliation: Ematologia, Dipartimento di Biomedicina e Prevenzione, Università Tor Vergata, Rome, Italy.
authors.forename: Adriano
authors.initials: A
authors.lastname: Venditti
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D060828:Induction Chemotherapy / Q000009:adverse effects*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000209:etiology*; D020360:Neoadjuvant Therapy; D012074:Remission Induction; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult
keywords: Acute myeloid leukemia; Aspergillosis; Complete remission; Invasive fungal disease; Survival