title: The role of positron emission tomography/computed tomography imaging with radiolabeled choline analogues in prostate cancer.
abstract: BACKGROUND
  prostate cancer is the most frequent solid malignant tumor in Western Countries. Positron emission tomography/x-ray computed tomography imaging with radiolabeled choline analogues is a useful tool for restaging prostate cancer in patients with rising prostate-specific antigen after radical treatment (in whom conventional imaging techniques have important limitations) as well as in the initial assessment of a selected group of prostate cancer patients. For this reason a literature review is necessary in order to evaluate the usefulness of this imaging test for the diagnosis and treatment of prostate cancer.
  
  
  METHODS
  a MEDLINE (PubMed way) literature search was performed using the search parameters: «Prostate cancer» and «Choline-PET/CT». Other search terms were «Biochemical failure» and/or «Staging» and/or «PSA kinetics». English and Spanish papers were selected; original articles, reviews, systematic reviews and clinical guidelines were included.
  
  
  CONCLUSIONS
  according to available data, radiolabeled choline analogues plays an important role in the management of prostate cancer, especially in biochemical relapse because technique accuracy is properly correlated with prostate-specific antigen values and kinetics. Although is an emerging diagnostic technique useful in treatment planning of prostate cancer, final recommendations have not been submitted.
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, España. Electronic address: mnavarropelayo@gmail.com.
authors.forename: M M
authors.initials: MM
authors.lastname: Navarro-Pelayo Láinez
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, España.
authors.forename: A
authors.initials: A
authors.lastname: Rodríguez-Fernández
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, España.
authors.forename: M
authors.initials: M
authors.lastname: Gómez-Río
authors.affiliation: Servicio de Urología, Hospital Universitario Virgen de las Nieves, Granada, España.
authors.forename: F
authors.initials: F
authors.lastname: Vázquez-Alonso
authors.affiliation: Servicio de Urología, Hospital Universitario Virgen de las Nieves, Granada, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Cózar-Olmo
authors.affiliation: Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, España.
authors.forename: J M
authors.initials: JM
authors.lastname: Llamas-Elvira
mesh_terms: D002794:Choline / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009367:Neoplasm Staging; D000072078:Positron Emission Tomography Computed Tomography; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D019275:Radiopharmaceuticals
chemical_list: D019275:Radiopharmaceuticals; D017430:Prostate-Specific Antigen; D002794:Choline
keywords: Biochemical relapse; Choline; Cinética antígeno prostático específico; Colina; Cáncer de próstata; Estadificación; Positron emission tomography/computed tomography; Prostate cancer; Prostate specific antigen kinetics; Recurrencia bioquímica; Staging; Tomografía por emisión de positrones/tomografía computarizada