title: Fluorescent probes for detecting monoamine oxidase activity and cell imaging.
abstract: A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and β-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 μg mL(-1) respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells.
authors.affiliation: Institute of Bioengineering, Zhejiang University of Technology, Chaowang Road 18, Hangzhou 310014, China. zhuq@zjut.edu.cn.
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Li
authors.forename: Huatang
authors.initials: H
authors.lastname: Zhang
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Hu
authors.forename: Hongyan
authors.initials: H
authors.lastname: Sun
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D004789:Enzyme Activation; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000032:analysis* / Q000378:metabolism; D014966:Xanthenes / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D014966:Xanthenes; D008995:Monoamine Oxidase