title: Association between histological findings, aminotransferase levels and viral genotype in chronic hepatitis C infection.
abstract: BACKGROUND
  The genomic heterogeneity of hepatitis C virus (HCV) influences liver disorders. This study aimed to determine the prevalence of HCV genotypes and to investigate the influence of these genotypes on disease progression.
  
  
  METHODS
  Blood samples and liver biopsies were collected from HCV-seropositive patients for serological analysis, biochemical marker measurements, HCV genotyping and histopathological evaluation.
  
  
  RESULTS
  Hepatitis C virus-ribonucleic acid (HCV-RNA) was detected in 107 patients (90.6% with genotype 1 and 9.4% with genotype 3). Patients infected with genotype 1 exhibited higher mean necroinflammatory activity and fibrosis.
  
  
  CONCLUSIONS
  HCV genotype 1 was the most prevalent and was associated with greater liver dysfunction.
authors.forename: Amanda Alves
authors.initials: AA
authors.lastname: Fecury
authors.forename: Marcella Kelly Costa de
authors.initials: MK
authors.lastname: Almeida
authors.forename: Kemper Nunes dos
authors.initials: KN
authors.lastname: Santos
authors.forename: Andrei da Silva
authors.initials: Ada S
authors.lastname: Freitas
authors.forename: Socorro de Fátima Loureiro
authors.initials: Sde F
authors.lastname: Dantas
authors.forename: Carlos Araújo da
authors.initials: CA
authors.lastname: Costa
authors.forename: Ângelo Barlleta
authors.initials: ÂB
authors.lastname: Crescente
authors.forename: Rita Catarina Medeiros de
authors.initials: RC
authors.lastname: Sousa
authors.forename: Elza Baía de
authors.initials: EB
authors.lastname: Brito
authors.forename: Reza
authors.initials: R
authors.lastname: Nassiri
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Lampe
authors.forename: Luisa Caricio
authors.initials: LC
authors.lastname: Martins
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000201:enzymology / Q000473:pathology / Q000821:virology*; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology / Q000821:virology*; D008297:Male; D012367:RNA, Viral / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D012367:RNA, Viral; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase