title: Cardiovascular risks in relation to daidzein metabolizing phenotypes among Chinese postmenopausal women.
abstract: BACKGROUND
  Studies suggested that the inter-individual differences in metabolizing isoflavone daidzein to equol or O-desmethylangolensin (ODMA) might explain the inconsistency of the soy/isoflavones efficacy on cardiovascular health.
  
  
  OBJECTIVE
  The study aims to evaluate the relationship between equol and ODMA phenotypes and cardiovascular risks with habitual isoflavone consumption in Chinese postmenopausal women.
  
  
  METHODS
  This is a cross-sectional study among 726 prehypertensive postmenopal women who were screened for a randomized controlled trial. 648 women returned a daidzein-challenged urine samples for determination of equol and O-DMA production. 595 attended clinic visits for assessment of cardiovascular risks including body composition, blood pressure (BP), serum lipids, uric acid, high sensitivity C-reactive protein (hs-CRP), fasting glucose and free fatty acid (FFA).
  
  
  RESULTS
  The prevalences of equol and O-DMA producers were 53.2% and 60.9% respectively. Equol producers had higher fat free mass (p = 0.001), lower systolic (p = 0.01) and diastolic (p = 0.01) BP, serum triglyceride (p = 0.023), hs-CRP (p = 0.015) and FFA (p = 0.001) than non-producers. O-DMA producers had lower body fat% (p = 0.032), SBP (p = 0.02), total cholesterol (p = 0.002) than non-producers. The significant differences remained after further adjustment for potential confounders. The habitual soy isoflavones intake had little relation to cardiovascular risk factors in either equol/O-DMA producer phenotypes.
  
  
  CONCLUSIONS
  Equol/O-DMA producers had more favorable cardiovascular risk profiles than non-producers in prehypertensive postmenopausal women.
authors.affiliation: Department of Medicine &Therapeutics, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Zhao-min
authors.initials: ZM
authors.lastname: Liu
authors.affiliation: Division of Epidemiology, The Jockey Club School of Public Health and Primary Care, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Suzanne C
authors.initials: SC
authors.lastname: Ho
authors.affiliation: Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, PR, China.
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Chen
authors.affiliation: Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, PR, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Medicine &Therapeutics, the Chinese University of Hong Kong, Hong Kong SAR, China.
authors.forename: Jean
authors.initials: J
authors.lastname: Woo
mesh_terms: D000368:Aged; D000886:Anthropometry; D044466:Asian People; D001794:Blood Pressure; D001823:Body Composition; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002319:Cardiovascular System / Q000187:drug effects; D002681:China; D003430:Cross-Sectional Studies; D060754:Equol / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D008019:Life Style; D008875:Middle Aged; D010641:Phenotype; D017698:Postmenopause; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors
chemical_list: D007529:Isoflavones; D060754:Equol; C004742:daidzein; C050052:O-desmethylangolensin