title: Development of antiviral agents toward enterovirus 71 infection.
abstract: Enterovirus 71 (EV71) infection remains a public health problem at a global level, particularly in the Asia-Pacific region. The infection normally manifests as hand-foot-mouth disease; however, it is capable of developing into potentially fatal neurological complications. There is currently no approved vaccine or antiviral substance available for the prevention or treatment of EV71 infection. This paper, thus, reviews efforts to develop or discover synthetic as well as naturally occurring compounds directed against EV71 infection. The recent achievements in cellular receptors of EV71 are also highlighted, and their contribution to the development of antiviral drugs against EV71 is discussed in this article.
authors.affiliation: Iranian Academic Centre for Education, Culture and Research (ACECR)-Mashhad Branch, Mashhad, Iran; Environment and Biotechnology Centre, Swinburne University of Technology, Melbourne, Australia. Electronic address: pourianfar@acecr.ac.ir.
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Pourianfar
authors.affiliation: Environment and Biotechnology Centre, Swinburne University of Technology, Melbourne, Australia.
authors.forename: Lara
authors.initials: L
authors.lastname: Grollo
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D029821:Enterovirus A, Human / Q000187:drug effects*; D004769:Enterovirus Infections / Q000188:drug therapy* / Q000821:virology*; D006801:Humans; D011991:Receptors, Virus / Q000187:drug effects / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D011991:Receptors, Virus
keywords: Antiviral agents; EV71 infection; EV71 receptors; Phytochemicals