title: A survey on the applications of implantable micropump systems in drug delivery.
abstract: Systemic drug delivery is the most prevalent form of the drug administration; but it is not possible to extend this approach to all of diseases. In the traditional approaches of drug delivery, the drug spreads through whole of body and this could cause severe side effects in the healthy parts. In addition, in some parts of our body like the eye, ear and brain, there are biological barriers against drug penetration which made drug delivery to these organs as a challenging work. Micropumps are one of the MEMS based devices with great capabilities in controlled drug administration. The most prevalent application of micropumps in drug delivery is known as continuous subcutaneous insulin infusion (CSII) for diabetic patients; but our study showed that there are some other ongoing investigations to extend application of micropumps in new treatment methods for some incurred diseases.
authors.forename: Ali
authors.initials: A
authors.lastname: Mahnama
authors.forename: Ahmad
authors.initials: A
authors.lastname: Nourbakhsh
authors.affiliation: Hydraulic Machinery Research Inst., School of Mechanical Engineering, College of Engineering, University of Tehran, North Kargar St., Tehran, Iran. nourbakhshahmad@yahoo.com.
authors.forename: Ghader
authors.initials: G
authors.lastname: Ghorbaniasl
mesh_terms: D059250:Administration, Metronomic; D060433:Administration, Ophthalmic; D000818:Animals; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D015918:Infusion Pumps, Implantable; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems; D008904:Miniaturization
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin