title: Functional annotation of rheumatoid arthritis and osteoarthritis associated genes by integrative genome-wide gene expression profiling analysis.
abstract: BACKGROUND
  Rheumatoid arthritis (RA) and osteoarthritis (OA) are two major types of joint diseases that share multiple common symptoms. However, their pathological mechanism remains largely unknown. The aim of our study is to identify RA and OA related-genes and gain an insight into the underlying genetic basis of these diseases.
  
  
  METHODS
  We collected 11 whole genome-wide expression profiling datasets from RA and OA cohorts and performed a meta-analysis to comprehensively investigate their expression signatures. This method can avoid some pitfalls of single dataset analyses.
  
  
  CONCLUSIONS
  We found that several biological pathways (i.e., the immunity, inflammation and apoptosis related pathways) are commonly involved in the development of both RA and OA. Whereas several other pathways (i.e., vasopressin-related pathway, regulation of autophagy, endocytosis, calcium transport and endoplasmic reticulum stress related pathways) present significant difference between RA and OA. This study provides novel insights into the molecular mechanisms underlying this disease, thereby aiding the diagnosis and treatment of the disease.
authors.affiliation: Department of Orthopaedic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Zhan-Chun
authors.initials: ZC
authors.lastname: Li
authors.affiliation: Department of Anesthesiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Jie
authors.initials: J
authors.lastname: Xiao
authors.affiliation: School of Biomedical Engineering/MED-X Research Institute, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Jin-Liang
authors.initials: JL
authors.lastname: Peng
authors.affiliation: Department of Orthopaedic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Chen
authors.affiliation: Department of Orthopaedic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Tao
authors.initials: T
authors.lastname: Ma
authors.affiliation: Department of Orthopaedic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Guang-Qi
authors.initials: GQ
authors.lastname: Cheng
authors.affiliation: Department of Orthopaedic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Yu-Qi
authors.initials: YQ
authors.lastname: Dong
authors.affiliation: Department of Orthopaedic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Wang
authors.affiliation: Department of Orthopaedic Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China.
authors.forename: Zu-De
authors.initials: ZD
authors.lastname: Liu
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics*; D016022:Case-Control Studies; D030541:Databases, Genetic; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D063990:Gene Ontology; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D058977:Molecular Sequence Annotation; D020411:Oligonucleotide Array Sequence Analysis; D010003:Osteoarthritis / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics