title: Interlaboratory testing of Insent e-tongues.
abstract: The first interlaboratory testing of electronic taste sensing systems was performed within five participating centers, each working with the Insent (Insent Inc., Atsugi-Shi, Japan) e-tongue. Preparation of the samples for the comprised four experiments, shipping of the samples and evaluation of the results was performed at the University of Duesseldorf. The sensitivity (in this case the difference between lowest and highest sensor response) and slope of the regression line values, obtained within Experiment 1 and 2, have been found to serve as applicable evaluation criterions for interlaboratory comparability. Modified sensor responses could be attributed to aged sensors, but did not influence the results of either Experiment 3, dealing with the evaluation of film formulations, or Experiment 4, dealing with the evaluation of minitablet formulations, in a great amount. Presented PCA Score and Loading Scatter Plots as well as Euclidean distance patterns based on the raw sensor responses confirmed the comparable performance of Insent e-tongues of the participating centers.
authors.affiliation: Institute of Pharmaceutics and Biopharmaceutics, Heinrich-Heine University Duesseldorf, Universitaetsstr. 1, 40225 Duesseldorf, Germany. Electronic address: miriam.pein@hhu.de.
authors.forename: Miriam
authors.initials: M
authors.lastname: Pein
authors.affiliation: University College London, School of Pharmacy, 29-39 Brunswick Square, London, UK.
authors.forename: Xolani Dereck
authors.initials: XD
authors.lastname: Gondongwe
authors.affiliation: Insent (Intelligent Sensor Technology) Inc., Atsugi, Kanagawa, Japan. Electronic address: habara.masaaki@insent.co.jp.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Habara
authors.affiliation: Novartis Pharma AG, Basel, Switzerland. Electronic address: gesine.winzenburg@novartis.com.
authors.forename: Gesine
authors.initials: G
authors.lastname: Winzenburg
mesh_terms: D004111:Dimenhydrinate / Q000737:chemistry; D055615:Electrical Equipment and Supplies; D005079:Excipients / Q000737:chemistry; D007753:Laboratories; D011189:Potassium Chloride / Q000737:chemistry; D013607:Tablets; D013649:Taste; D013678:Technology, Pharmaceutical / Q000295:instrumentation*; D014059:Tongue
chemical_list: D005079:Excipients; D013607:Tablets; D011189:Potassium Chloride; D004111:Dimenhydrinate
keywords: Dimenhydrinate (PubChem CID: 10660); Electronic taste sensing system; EuPFi; Interlaboratory; Quinine hydrochloride (PubChem CID: 16211283); Saccharin sodium (PubChem CID: 656582); Sensor age; Sensor performance; Sodium cyclamate (PubChem CID: 23665706); Zinc sulphate (PubChem CID: 62640)