title: In situ proteome profiling of C75, a covalent bioactive compound with potential anticancer activities.
abstract: A library of cell-permeable, minimally tagged C75 analogues was synthesized and used to uncover biological targets in human liver cancer cells. Known targets of C75, namely FASN and CPT1A, together with other unknown targets, including PDIA3, TFRC, and GAPDH, were thus identified.
authors.affiliation: Department of Chemistry, National University of Singapore , 3 Science Drive 3, Singapore, 117543.
authors.forename: Xiamin
authors.initials: X
authors.lastname: Cheng
authors.forename: Lin
authors.initials: L
authors.lastname: Li
authors.forename: Mahesh
authors.initials: M
authors.lastname: Uttamchandani
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D006801:Humans; D008113:Liver Neoplasms; D015394:Molecular Structure; D054852:Small Molecule Libraries
chemical_list: D000970:Antineoplastic Agents; D054852:Small Molecule Libraries; D015107:4-Butyrolactone