title: Association of the ADIPOQ T45G polymorphism with insulin resistance and blood glucose: a meta-analysis.
abstract: Results of published studies on the association of the ADIPOQ T45G polymorphism with insulin resistance (IR) and blood glucose are conflicting. In this study, we performed a meta-analysis to further investigate such an association. Articles that evaluate the effect of the T45G polymorphism on IR and blood glucose were identified from the PubMed and Embase databases. Five indices, including fasting blood glucose (FBG), fasting insulin (F-insulin), 2-h blood glucose (2-h BG), 2-h insulin, and homeostasis model assessment insulin resistance index (HOMA-IR), were used to assess the effects of the T45G polymorphism on IR and blood glucose under a dominant model. 24 articles involving 7630 subjects were included. Twenty-two studies on FBG, 17 on F-insulin, 20 on HOMA-IR, and 3 on 2-h BG were included. No study on 2-h insulin was found. This meta-analysis revealed no significant association between the ADIPOQ T45G polymorphism and IR and blood glucose in the overall population and subgroup subjects under a dominant model, regardless of whether FBG, F-insulin, 2-h BG, or HOMA-IR was used. The present meta-analysis indicated that the mutation allele may have no function in IR development. The ADIPOQ T45G polymorphism is not associated with IR and blood glucose.
authors.affiliation: Department of Biochemistry, Peking University Capital Institute of Pediatrics Teaching Hospital, Beijing 100020, China.
authors.forename: Dingding
authors.initials: D
authors.lastname: Cao
authors.forename: Shengrong
authors.initials: S
authors.lastname: Ouyang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Liu
authors.forename: Feifei
authors.initials: F
authors.lastname: Ma
authors.forename: Jianxin
authors.initials: J
authors.lastname: Wu
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D019943:Amino Acid Substitution; D001786:Blood Glucose / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005998:Glycine / Q000235:genetics; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013912:Threonine / Q000235:genetics
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D013912:Threonine; D005998:Glycine