title: Emergence of OXA-162-producing Klebsiella pneumoniae in Hungary.
abstract: In August 2012, 2 carbapenem-resistant Klebsiella pneumoniae isolates from the University of Szeged were submitted to the National Reference Laboratory at the National Centre for Epidemiology to confirm the carbapenem resistance mechanism. PCR assays and sequencing revealed that the isolates harboured the blaOXA-162 carbapenemase gene, a very recently described variant of OXA-48, and the blaCTX-M-15 extended-spectrum β-lactamase gene. The isolates had indistinguishable PFGE patterns and belonged to sequence type ST15. To the best of our knowledge, this is the first description of OXA-48-like carbapenemase-producing bacteria in Hungary and of an OXA-162-type carbapenemase gene in the K. pneumoniae ST15 clone.
authors.affiliation: From the Department of Bacteriology, National Centre for Epidemiology , Budapest.
authors.forename: Laura
authors.initials: L
authors.lastname: Jánvári
authors.forename: Ivelina
authors.initials: I
authors.lastname: Damjanova
authors.forename: Andrea
authors.initials: A
authors.lastname: Lázár
authors.forename: Katalin
authors.initials: K
authors.lastname: Rácz
authors.forename: Béla
authors.initials: B
authors.lastname: Kocsis
authors.forename: Edit
authors.initials: E
authors.lastname: Urbán
authors.forename: Ákos
authors.initials: Á
authors.lastname: Tóth
mesh_terms: D016000:Cluster Analysis; D006801:Humans; D006814:Hungary; D007223:Infant; D007710:Klebsiella Infections / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D008297:Male; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D001618:beta-Lactamases; C108449:oxacillinase