title: Targeting virulence not viability in the search for future antibacterials.
abstract: New antibacterials need new approaches to overcome the problem of rapid antibiotic resistance. Here we review the development of potential new antibacterial drugs that do not kill bacteria or inhibit their growth, but combat disease instead by targeting bacterial virulence.
authors.affiliation: La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Vic.
authors.forename: Begoña
authors.initials: B
authors.lastname: Heras
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Scanlon
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Martin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000472:pathogenicity; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D015195:Drug Design; D024881:Drug Resistance, Bacterial; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents
keywords: antibacterial; antivirulence; bacterial infection; pilicide; quorum sensing