title: N-containing metabolites from the marine sponge Agelas clathrodes.
abstract: A new bisuracil analogue, 3,3-bis(uracil-1-yl)-propan-1-aminium (1), together with four known N-containing metabolites (2-5), were isolated from the South China Sea sponge Agelas clathrodes. Their chemical structures were established on the basis of spectroscopic and spectrometric analysis and comparison with known compounds. Compound 1 is an unusual naturally occurring bisuracil analogue, and compound 2 was isolated from a natural source for the first time. Compounds 2 and 4 exhibit moderate cytotoxicity against cancer cell line SGC7901.
authors.affiliation: Department ofPharmacy, Renji Hospital, Shanghai Jiao Tong University School ofMedicine, 160 Pujian Road, Shanghai 200127, P.R. China franklin67@126.com
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.affiliation: Department of Anesthesiology, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, P.R. China.
authors.forename: Rui-Hua
authors.initials: RH
authors.lastname: Ji
authors.affiliation: Eastern Hepatobiliary Surgical Hospital, Second Military Medical University, 225 Changhai Road, Shanghai 200438, P.R. China
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.affiliation: College of Food Science & Technology, Shanghai Ocean University, 999 Hucheng Huan Road, Shanghai 201306, P.R. China.
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Gan
authors.affiliation: Department ofPharmacy, Renji Hospital, Shanghai Jiao Tong University School ofMedicine, 160 Pujian Road, Shanghai 200127, P.R. China
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry* / Q000378:metabolism; D014498:Uracil / Q000031:analogs & derivatives*
chemical_list: D000970:Antineoplastic Agents; D014498:Uracil