title: Infant 7-valent pneumococcal conjugate vaccine immunization alters young adulthood CD4(+)T cell subsets in allergic airway disease mouse model.
abstract: 7-Valent pneumococcal conjugate vaccine (PCV7) immunization in adulthood can inhibit allergic asthma in mouse model. The aim of this study is to investigate the effects of infant PCV7 immunization on young adulthood CD4(+)T cell subsets in a murine allergic airway disease (AAD) model. Our study indicated that infant PCV7 immunization can inhibit young adulthood airway inflammation and airway hyperresponsiveness (AHR) by inducing the production of Foxp3(+)Treg, Th1 cells and their cytokines IL-10 and IFN-γ, inhibiting the production of Th2, Th17 cells and their cytokines IL-13 and IL-17A in BALB/c mice model. These results suggested that infant PCV7 immunization may serve as an effective measure to prevent young adulthood mice AAD.
authors.affiliation: Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: Liqun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China; Ultrasound division, Children's Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Gao
authors.affiliation: Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Yang
authors.affiliation: Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: Baohui
authors.initials: B
authors.lastname: Yang
authors.affiliation: Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China.
authors.forename: Lijia
authors.initials: L
authors.lastname: Wang
authors.affiliation: Ministry of Education, Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China; The Central Laboratory of Children's Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Qinghong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Respiratory, Children's Hospital, Chongqing Medical University, Chongqing, China. Electronic address: luozhengxiu816@163.com.
authors.forename: Zhengxiu
authors.initials: Z
authors.lastname: Luo
authors.affiliation: Department of Respiratory, Children's Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Enmei
authors.initials: E
authors.lastname: Liu
authors.affiliation: Department of Respiratory, Children's Hospital, Chongqing Medical University, Chongqing, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Fu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001249:Asthma / Q000517:prevention & control*; D004804:Eosinophils / Q000276:immunology; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D007249:Inflammation / Q000517:prevention & control*; D007371:Interferon-gamma / Q000276:immunology; D016753:Interleukin-10 / Q000276:immunology; D008168:Lung / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000276:immunology; D022242:Pneumococcal Vaccines / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D022242:Pneumococcal Vaccines; D016753:Interleukin-10; D007371:Interferon-gamma
keywords: Allergic airway disease; Foxp3(+)Treg cell; Infant PCV7 immunization; Th17; Th2; Young adulthood