title: [Expression and significance of UNC-112 protein in lung cancer].
abstract: OBJECTIVE
  To investigate the expression of UNC-112 protein in lung cancer and discuss its value.
  
  
  METHODS
  The method of immunohistochemical SP was employed to detect the expression of UNC-112 protein in 210 cases of lung cancer, and evaluate its correlation with pathological classification.
  
  
  RESULTS
  UNC-112A and UNC-112B protein were highly expressed in non-small cell lung cancer, not expressed or expressed at very low levels in small cell lung cancer(P < 0.05);the expression of UNC-112A protein in squamous cell carcinoma was significantly higher than those in adenocarcinoma (P < 0.001)and large cell lung cancer (P < 0.01), but there is no significant difference between adenocarcinoma and large cell lung cancer (P = 0.18).UNC-112A protein expression level was positively correlated with the differentiation of squamous cell carcinoma(P = 0.0024). The expression of UNC-112B protein was significantly higher in large cell lung cancer than those in adenocarcinoma (P = 0.002) and squamous cell carcinoma (P < 0.01), and it was significantly higher in adenocarcinoma than squamous cell carcinoma (P = 0.005).
  
  
  CONCLUSIONS
  UNC-112 protein may be related to the heterogeneity of lung cancer, UNC-112A and UNC-112B protein play different roles in invasion and migration of lung cancer.
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Guang-liang
authors.initials: GL
authors.lastname: Qiang
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Qi-duo
authors.initials: QD
authors.lastname: Yu
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.affiliation: Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing 100029, China. Email: guoyongqing@aliyun.com.
authors.forename: Yong-qing
authors.initials: YQ
authors.lastname: Guo
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018287:Carcinoma, Large Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D055752:Small Cell Lung Carcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology
chemical_list: C475301:FERMT1 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins