title: Arg347Cys polymorphism of α1a-adrenergic receptor in vasovagal syncope. Case-control study in a Mexican population.
abstract: BACKGROUND
  Vasovagal syncope is a common clinical condition, consequential to reduced cerebral blood flow resulting from a failure in cardiovascular homeostasis during orthostasis. Blood pressure regulation is the basis for syncope development. In this regulation, the α1a-adrenergic receptor plays a major role. Some studies have found a positive correlation between the Arg347Cys polymorphism of the α1a-adrenergic receptor to hypertension and heart autonomic control. The goal of this study is to evaluate the possible association between the Arg347Cys α1a-adrenergic receptor polymorphism and vasovagal syncope in a Mexican population.
  A sample of 89 vasovagal syncope patients and 40 healthy controls were studied. Arg347Cys α1a-adrenergic receptor polymorphism was determined by the PCR-RFLP method. We found an increased frequency of genotype ArgArg in vasovagal syncope patients. In a logistic regression model significant associations were found in two genetic models, in codominant model (OR=13.21: CI 95% 3.69-54.99, p<0.001) and in additive model (OR=12.68: CI 95% 3.5-53.07, p<0.001) for ArgArg genotype with CysCys as reference.
  
  
  CONCLUSIONS
  Our data suggests an important participation of Arg347Cys polymorphism as susceptibility factor in patients with vasovagal syncope. ArgArg genotype could be a marker for vasovagal syncope susceptibility in the Mexican population.
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico; PhD Program in Biological Sciences and Health, Universidad Autónoma Metropolitana, Mexico. Electronic address: mghp60@yahoo.com.
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Hernández-Pacheco
authors.affiliation: Medical Branch, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico.
authors.forename: Antonio
authors.initials: A
authors.lastname: González-Hermosillo
authors.affiliation: Department of Methodology, Instituto Nacional de Pediatría, Mexico.
authors.forename: Chiharu
authors.initials: C
authors.lastname: Murata
authors.affiliation: Department of Genetics, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez", Mexico.
authors.forename: Petra
authors.initials: P
authors.lastname: Yescas
authors.affiliation: Department of Echocardiography, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico.
authors.forename: Nilda
authors.initials: N
authors.lastname: Espínola-Zavaleta
authors.affiliation: Department of Physiology, Instituto Nacional de Cardiología "Ignacio Chávez", Mexico.
authors.forename: Martín
authors.initials: M
authors.lastname: Martínez
authors.affiliation: Department of Health Sciences, Universidad Autónoma Metropolitana-Iztapalapa, Mexico.
authors.forename: Héctor
authors.initials: H
authors.lastname: Serrano
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D016022:Case-Control Studies; D002648:Child; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D060005:Genotyping Techniques; D006801:Humans; D016015:Logistic Models; D008297:Male; D008800:Mexico; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D018340:Receptors, Adrenergic, alpha-1 / Q000235:genetics*; D012737:Sex Factors; D019462:Syncope, Vasovagal / Q000235:genetics*; D055815:Young Adult
chemical_list: C547713:ADRA1A protein, human; D018340:Receptors, Adrenergic, alpha-1
keywords: Adrenergic receptor; Autonomic nervous system; Genes; Syncope