title: Confidence intervals for intraclass correlation coefficients in variance components models.
abstract: Confidence intervals for intraclass correlation coefficients in agreement studies with continuous outcomes are model-specific and no generic approach exists. This paper provides two generic approaches for intraclass correlation coefficients of the form [Formula: see text] The first approach uses Satterthwaite's approximation and an F-distribution. The second approach uses the first and second moments of the intraclass correlation coefficient estimate in combination with a Beta distribution. Both approaches are based on the restricted maximum likelihood estimates for the variance components involved. Simulation studies are conducted to examine the coverage probabilities of the confidence intervals for agreement studies with a mix of small sample sizes. Two different three-way variance components models and balanced and unbalanced one-way random effects models are investigated. The proposed approaches are compared with other approaches developed for these specific models. The approach based on the F-distribution provides acceptable coverage probabilities, but the approach based on the Beta distribution results in accurate coverages for most settings in both balanced and unbalanced designs. A real agreement study is provided to illustrate the approaches.
authors.affiliation: Department of Epidemiology, University Medical Center Groningen, University of Groningen, RB Groningen, The Netherlands Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, AK Groningen, The Netherlands n.demetrashvili@umcg.nl.
authors.forename: Nino
authors.initials: N
authors.lastname: Demetrashvili
authors.affiliation: Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, AK Groningen, The Netherlands.
authors.forename: Ernst C
authors.initials: EC
authors.lastname: Wit
authors.affiliation: Department of Epidemiology, University Medical Center Groningen, University of Groningen, RB Groningen, The Netherlands Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen, AK Groningen, The Netherlands.
authors.forename: Edwin R
authors.initials: ER
authors.lastname: van den Heuvel
mesh_terms: D000704:Analysis of Variance; D016001:Confidence Intervals; D006801:Humans; D016013:Likelihood Functions; D008495:Medical Oncology; D018401:Sample Size; D013363:Submandibular Gland / Q000473:pathology
keywords: ANOVA; Beta distribution; F-distribution; REML; agreement study