title: [Clinical analysis of intraoperative radiotherapy in breast-conserving surgery of early breast cancer].
abstract: OBJECTIVE
  To evaluate the safety and feasibility of intraoperative radiotherapy during breast-conserving surgery instead of whole breast radiotherapy in early breast cancer patients.
  
  
  METHODS
  From July 2008 to December 2012, 36 early breast cancer patients underwent breast-conserving surgery plus interoperative radiotherapy on a Mobetron 1000 mobile electron accelerator. Postoperative recurrence and metastases, complications and cosmetic outcomes were recorded and analyzed.
  
  
  RESULTS
  During a median follow-up period of 27.9 months, 2 patients (5.56%) underwent mastectomy after local relapses. There was no occurrence of distant metastasis or mortality. Their average wound healing time was 17 days and 2 of them (5.56%) developed infection while another 2 (5.56%) had delayed wound healing. And 1 patient (2.78%) showed wound edema and neither necrosis nor hematoma was found. The evaluation of cosmetic outcome shows 32 patients (88.89%) were graded as excellent or good while another 4 (11.11%) fair or poor. None had radiotherapy-related acute hemotological toxicity and 2 patients (5.56%) developed skin pigmentation.
  
  
  CONCLUSIONS
  Intraoperative radiotherapy during breast-conserving surgery instead of whole breast radiotherapy in early breast cancer patients is both safe and reliable with better cosmetic outcomes.
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Qin-fu
authors.initials: QF
authors.lastname: Feng
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Wen-yan
authors.initials: WY
authors.lastname: Wang
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Ji-dong
authors.initials: JD
authors.lastname: Gao
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Li-xue
authors.initials: LX
authors.lastname: Xuan
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Ye-xiong
authors.initials: YX
authors.lastname: Li
authors.affiliation: Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. Email: xiangw@vip.sina.com.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D015412:Mastectomy, Segmental / Q000379:methods*; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome