title: Colchicine-responsive protracted gouty arthritis with systemic inflammatory reactions.
abstract: Acute gouty arthritis is a severe but self-limiting arthritis caused by inflammatory responses to urate crystals. Oral colchicines are effective for initial stages or prophylaxis, but generally, colchicines are ineffective for established gouty arthritis. We describe an unusual case of gouty arthritis with systemic inflammatory reactions, including high fever and polymyalgia. Refractory polyarthritis and high fever were eradicated by colchicine treatment. Genetic analysis revealed a heterozygous mutation in exon 2 of the MEFV gene (E148Q). This case underscores the possibility that MEFV gene mutations may modify the phenotype of gouty arthritis.
authors.affiliation: Department of Rheumatology, Sasebo City General Hospital , Sasebo , Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Nonaka
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.forename: Tomoko
authors.initials: T
authors.lastname: Haramura
authors.forename: Remi
authors.initials: R
authors.lastname: Sumiyoshi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D015210:Arthritis, Gouty / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D003078:Colchicine / Q000627:therapeutic use*; D003598:Cytoskeletal Proteins / Q000235:genetics; D005334:Fever / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D006074:Gout Suppressants / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D000071198:Pyrin; D016896:Treatment Outcome
chemical_list: D003598:Cytoskeletal Proteins; D006074:Gout Suppressants; C000604192:MEFV protein, human; D000071198:Pyrin; D003078:Colchicine