title: Role of adult neurogenesis in hippocampal-cortical memory consolidation.
abstract: Acquired memory is initially dependent on the hippocampus (HPC) for permanent memory formation. This hippocampal dependency of memory recall progressively decays with time, a process that is associated with a gradual increase in dependency upon cortical structures. This process is commonly referred to as systems consolidation theory. In this paper, we first review how memory becomes hippocampal dependent to cortical dependent with an emphasis on the interactions that occur between the HPC and cortex during systems consolidation. We also review the mechanisms underlying the gradual decay of HPC dependency during systems consolidation from the perspective of memory erasures by adult hippocampal neurogenesis. Finally, we discuss the relationship between systems consolidation and memory precision.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitamura
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Graduate School of Medicine & Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan. inokuchi@med.u-toyama.ac.jp.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Inokuchi
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D055495:Neurogenesis / Q000502:physiology*