title: Toll-like receptor 3 polymorphism is not associated with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in the Chinese.
abstract: Toll-like receptor 3 (TLR3) variants in mainland northern Chinese patients with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) were investigated. The complete genes of TLR3, including all exons and the promoter region, were assessed using direct sequencing technology of 284 unrelated mainland northern Chinese individuals: 96 nAMD patients, 92 PCV patients, and 96 controls. Six single nucleotide polymorphisms were identified: rs5743303, rs5743305, rs5743312, rs3775291, rs3775290, and rs6830345. The distribution of TLR3 genotypes for nAMD and PCV was not significantly different compared with normal controls. This study indicates that the TLR3 gene polymorphism is not associated with nAMD and PCV in northern Chinese patients.
authors.affiliation: Department of Ophthalmology, People's Hospital, Peking University, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Ophthalmology, People's Hospital, Peking University, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: M W
authors.initials: MW
authors.lastname: Li
authors.affiliation: Ophthalmology Department, Peking University 3rd Hospital, Peking University Eye Center, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: H P
authors.initials: HP
authors.lastname: Li
authors.affiliation: Chinese National Human Genome Center, Beijing, China.
authors.forename: W T
authors.initials: WT
authors.lastname: Zeng
authors.affiliation: Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, China.
authors.forename: P
authors.initials: P
authors.lastname: Zhou
authors.affiliation: Department of Ophthalmology, People's Hospital, Peking University, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Huang
authors.affiliation: Department of Ophthalmology, People's Hospital, Peking University, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China drlixiaoxin@163.com.
authors.forename: X X
authors.initials: XX
authors.lastname: Li
authors.affiliation: Department of Ophthalmology, People's Hospital, Peking University, Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China.
authors.forename: Y Y
authors.initials: YY
authors.lastname: Sun
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002681:China; D015862:Choroid Diseases / Q000235:genetics*; D005091:Exons; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D051196:Toll-Like Receptor 3 / Q000235:genetics*
chemical_list: C495344:TLR3 protein, human; D051196:Toll-Like Receptor 3