title: Comparison of 8, 10, 12, 16, 20 cores prostate biopsies in the determination of prostate cancer and the importance of prostate volume.
abstract: BACKGROUND
  In this study, we evaluate the relationship between increasing core numbers and cancer detection rate.
  
  
  METHODS
  We included 1120 patients with prostate-specific antigen levels ≤20 ng/mL and/or suspicious digital rectal examination findings in this study. All patients had a first-time prostate biopsy and 8, 10, 12, 16, and 20 core biopsies were taken and examined in different groups during the study. Multiple logistic regression analysis was made to reach the factor affecting the cancer detection rate between the patients with and without cancer. A p < 0.05 was considered statistically significant.
  
  
  RESULTS
  Out of 1120 patients, 221 (19.7%) had prostate cancer. Again of the total 1120 patients, 8 core biopsies were taken from 229 (20.4%); 10 core biopsies from 473 (42.2%); 12 core biopsies from 100 (8.9%); 16 core biopsies from 140 (12.5%); and 20 core biopsies from 178 (15.9%) patients. The increase in the core number increased the cancer detection rate by 1.06 times (p = 0.008).
  
  
  CONCLUSIONS
  As long as prostate volume increases, increasing the core number elevates the cancer detection rate. Thus, the rate of missed cancer will be reduced and the rates of unnecessary repetitive biopsy decreases.
authors.affiliation: Department of Urology Clinic of Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey;
authors.forename: Cavit
authors.initials: C
authors.lastname: Ceylan
authors.affiliation: Ankara Training and Research Hospital, Ankara, Turkey;
authors.forename: Omer Gokhan
authors.initials: OG
authors.lastname: Doluoglu
authors.affiliation: Elazığ Training and Research Hospital, Urology Clinic, Elazığ, Turkey.
authors.forename: Erdogan
authors.initials: E
authors.lastname: Aglamis
authors.affiliation: Department of Urology Clinic of Türkiye Yüksek Ihtisas Training and Research Hospital, Ankara, Turkey;
authors.forename: Ozkan
authors.initials: O
authors.lastname: Baytok