title: Genetic background of juvenile idiopathic arthritis.
abstract: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatologic disease in children. JIA is a group of disorders that share the clinical manifestation of chronic joint inflammation. The human leukocyte antigen region (HLA) seems to be a major susceptibility locus for JIA that is estimated to account for 17% of familial segregation of the disease. To date, around 20 non-HLA loci conferring susceptibility to JIA were found. At least a half of those are shared between JIA and rheumatoid arthritis (RA), an adult rheumatic disease, thereby suggesting for similarity of pathogenic mechanisms of both diseases. New findings also suggest for a likely role of epigenetic alterations in the pathogenesis of JIA that should be investigated in the future.
authors.affiliation: Department of Medical Nanobiotechnology, Pirogov Russian State Medical University , Moscow , Russia and.
authors.forename: Dimitry A
authors.initials: DA
authors.lastname: Chistiakov
authors.forename: Kirill V
authors.initials: KV
authors.lastname: Savost'anov
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Baranov
mesh_terms: D000293:Adolescent; D001171:Arthritis, Juvenile / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans
chemical_list: D006680:HLA Antigens
keywords: Genetic association; juvenile idiopathic arthritis; polymorphism; rheumatoid arthritis; susceptibility