title: Validation of GAITRite and PROMIS as high-throughput physical function outcome measures following ACL reconstruction.
abstract: New healthcare demands for quality measures of elective procedures, such as anterior cruciate ligament (ACL) reconstructive surgery, warrant the establishment of high throughput outcomes for high volume clinics. To this end, we evaluated the PROMIS and GAITRite as physical function outcome measures to quantify early healing and post-operative complications in 106 patients at pre-operative and 3, 10, 20 and 52 weeks post-ACL reconstruction with bone-tendon-bone autograft, and compared the results to the current IKDC validated outcome measure. The results showed that both PROMIS and GAITRite were significantly quicker to administer versus IKDC (p<0.0001). Additional advantages were that PROMIS and GAITRite detected a significant decrease in physical function at 3 weeks post-operative, and a significant improvement at 10 weeks post-operative versus pre-operative (p<0.001), which were not detected with IKDC. GAITRite was limited by a low ceiling that could not detect improvement of physical function beyond 20 weeks, while both PROMIS and IKDC detected significant improvement out to 52 weeks post-operative (p<0.001). Linear regressions demonstrated a significant relationship between IKDC and PROMIS, with a combined correlation value of 0.8954 (p<0.001) for all time points. Finally, ROC curve analysis demonstrated that PROMIS is a diagnostic test for poor outcomes.
authors.affiliation: The Center for Musculoskeletal Research, University of Rochester, Rochester, New York; New York Chiropractic College, Seneca Falls, New York.
authors.forename: M Owen
authors.initials: MO
authors.lastname: Papuga
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Beck
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Kates
authors.forename: Edward M
authors.initials: EM
authors.lastname: Schwarz
authors.forename: Michael D
authors.initials: MD
authors.lastname: Maloney
mesh_terms: D000293:Adolescent; D000328:Adult; D016118:Anterior Cruciate Ligament / Q000601:surgery; D059549:Anterior Cruciate Ligament Reconstruction; D006801:Humans; D007718:Knee Injuries / Q000601:surgery; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011788:Quality of Life; D016059:Range of Motion, Articular; D013710:Tendons / Q000601:surgery; D016896:Treatment Outcome
keywords: ACL reconstruction; PROMIS; gait; physical function