title: Neurogenesis in the striatum of the adult human brain.
abstract: In most mammals, neurons are added throughout life in the hippocampus and olfactory bulb. One area where neuroblasts that give rise to adult-born neurons are generated is the lateral ventricle wall of the brain. We show, using histological and carbon-14 dating approaches, that in adult humans new neurons integrate in the striatum, which is adjacent to this neurogenic niche. The neuronal turnover in the striatum appears restricted to interneurons, and postnatally generated striatal neurons are preferentially depleted in patients with Huntington's disease. Our findings demonstrate a unique pattern of neurogenesis in the adult human brain.
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden.
authors.forename: Aurélie
authors.initials: A
authors.lastname: Ernst
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden; Department of Oncology-Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
authors.forename: Kanar
authors.initials: K
authors.lastname: Alkass
authors.affiliation: Institut Camille Jordan, CNRS UMR 5208, University of Lyon, 69622 Villeurbanne, France.
authors.forename: Samuel
authors.initials: S
authors.lastname: Bernard
authors.affiliation: Department of Physics and Astronomy, Ion Physics, Uppsala University, 751 20 Uppsala, Sweden.
authors.forename: Mehran
authors.initials: M
authors.lastname: Salehpour
authors.affiliation: NHLBI, NIH, Bethesda, Maryland 20892, USA.
authors.forename: Shira
authors.initials: S
authors.lastname: Perl
authors.affiliation: NHLBI, NIH, Bethesda, Maryland 20892, USA.
authors.forename: John
authors.initials: J
authors.lastname: Tisdale
authors.affiliation: Department of Physics and Astronomy, Ion Physics, Uppsala University, 751 20 Uppsala, Sweden.
authors.forename: Göran
authors.initials: G
authors.lastname: Possnert
authors.affiliation: Department of Oncology-Pathology, Karolinska Institute, 171 77 Stockholm, Sweden.
authors.forename: Henrik
authors.initials: H
authors.lastname: Druid
authors.affiliation: Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden. Electronic address: jonas.frisen@ki.se.
authors.forename: Jonas
authors.initials: J
authors.lastname: Frisén
mesh_terms: D000328:Adult; D000818:Animals; D001479:Basal Ganglia / Q000166:cytology* / Q000473:pathology / Q000502:physiology; D001921:Brain / Q000166:cytology / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D006801:Humans; D006816:Huntington Disease / Q000473:pathology; D007395:Interneurons / Q000166:cytology / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D009830:Olfactory Bulb / Q000166:cytology / Q000502:physiology