title: Spread of NDM-1-producing Enterobacteriaceae in a neonatal intensive care unit in Istanbul, Turkey.
abstract: Twenty-two consecutive carbapenem-resistant enterobacterial isolates were recovered from patients hospitalized between January and April 2013 in different units at a university hospital in Istanbul, Turkey. These were Klebsiella pneumoniae isolates producing the carbapenemases OXA-48, NDM-1, and KPC-2, Enterobacter cloacae isolates producing NDM-1, and Escherichia coli isolates producing OXA-48. Most of the OXA-48-producing K. pneumoniae and all the NDM-1-producing E. cloacae were clonally related. The NDM-1-producing E. cloacae isolates recovered from a single neonatal intensive care unit corresponded to a single cluster, highlighting the spread of that clone in that setting.
authors.affiliation: Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Fribourg, Switzerland.
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
authors.forename: Mesut
authors.initials: M
authors.lastname: Yilmaz
authors.forename: Ayse
authors.initials: A
authors.lastname: Istanbullu
authors.forename: Ferhat
authors.initials: F
authors.lastname: Arslan
authors.forename: Ali
authors.initials: A
authors.lastname: Mert
authors.forename: Sandrine
authors.initials: S
authors.lastname: Bernabeu
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000235:genetics; D004926:Escherichia coli / Q000201:enzymology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007362:Intensive Care Units; D007711:Klebsiella pneumoniae / Q000201:enzymology*; D008297:Male; D008826:Microbial Sensitivity Tests; D014421:Turkey; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1