title: Vascular and hepatic enhancements at MR imaging: comparison of Gd-EOB-DTPA and Gd-DTPA in the same subjects.
abstract: OBJECTIVE
  The objective was to compare vascular and hepatic enhancement differences at magnetic resonance imaging (MRI) between Gd-EOB-DTPA and Gd-DTPA in the same subjects.
  
  
  METHODS
  Ten healthy subjects received dynamic contrast-enhanced MRI (DCE-MRI) with Gd-EOB-DTPA and then Gd-DTPA to obtain quantitative parameters at 60 and 100 s, respectively.
  
  
  RESULTS
  At 60 s, no difference was noted in DCE-MRI parameters between the two contrast agents. At 100 s, mean transit time (MTT) was higher in Gd-EOB-DTPA than in Gd-DTPA (P=.008).
  
  
  CONCLUSIONS
  Gd-EOB-DTPA showed vascular and hepatic enhancement similar to Gd-DTPA within the initial 60 s during the dynamic phase, but showed increased MTT due to hepatocytes uptake at 100 s.
authors.affiliation: Department of Medical Imaging and Radiology, National Taiwan University College of Medicine and Hospital.
authors.forename: Yen-Heng
authors.initials: YH
authors.lastname: Lin
authors.affiliation: Department of Medical Imaging and Radiology, National Taiwan University College of Medicine and Hospital.
authors.forename: Ruey-Ming
authors.initials: RM
authors.lastname: Hwang
authors.affiliation: Department of Medical Imaging and Radiology, National Taiwan University College of Medicine and Hospital. Electronic address: bangbin@gmail.com.
authors.forename: Bang-Bin
authors.initials: BB
authors.lastname: Chen
authors.affiliation: Department of Medical Imaging and Radiology, National Taiwan University College of Medicine and Hospital.
authors.forename: Chao-Yu
authors.initials: CY
authors.lastname: Hsu
authors.affiliation: Department of Medical Imaging and Radiology, National Taiwan University College of Medicine and Hospital.
authors.forename: Chih-Wei
authors.initials: CW
authors.lastname: Yu
authors.affiliation: Department of Internal Medicine, National Taiwan University College of Medicine and Hospital; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine.
authors.forename: Jia-Horng
authors.initials: JH
authors.lastname: Kao
authors.affiliation: Department of Internal Medicine, National Taiwan University College of Medicine and Hospital.
authors.forename: Hsuan-Shu
authors.initials: HS
authors.lastname: Lee
authors.affiliation: Department of Medical Imaging and Radiology, National Taiwan University College of Medicine and Hospital.
authors.forename: Po-Chin
authors.initials: PC
authors.lastname: Liang
authors.affiliation: Department of Medical Imaging and Radiology, National Taiwan University College of Medicine and Hospital.
authors.forename: Shwu-Yuan
authors.initials: SY
authors.lastname: Wei
authors.affiliation: Department of Medical Imaging and Radiology, National Taiwan University College of Medicine and Hospital. Electronic address: ttfshih@ntu.edu.tw.
authors.forename: Tiffany Ting-Fang
authors.initials: TT
authors.lastname: Shih
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006499:Hepatic Artery; D006503:Hepatic Veins; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008099:Liver / Q000098:blood supply* / Q000166:cytology*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA
keywords: DCE-MRI; Gd-DTPA; Gd-EOB-DTPA; Perfusion imaging