title: ADP-ribosylation: activation, recognition, and removal.
abstract: ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly(ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases. These three groups of proteins work together to regulate the cellular and molecular response of PAR signaling, which is critical for a wide range of cellular and physiological functions.
authors.affiliation: Department of Experimental Radiation Oncology, Unit 66, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Junjie
authors.initials: J
authors.lastname: Chen
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000378:metabolism*; D000818:Animals; D004260:DNA Repair; D004789:Enzyme Activation; D006801:Humans; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary
chemical_list: D000246:Adenosine Diphosphate Ribose; D011065:Poly(ADP-ribose) Polymerases