title: Antibacterial activity of thioetherhydroxyethylsulfonamide derivatives.
abstract: Thioetherhydroxyethylsulfonamide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923). Results have shown that compounds 8c and 9e display potent activity (MIC = 0.125 µg/mL) against E. coli when compared with the standard drug sulfamethoxazole (SMZ, MIC < 0.5 µg/mL) for this same strain. All the new compounds were fully identified and characterized by NMR ((1)H and (13)C) and X-ray crystallography (for compound 8c). This class of compounds can be considered as a good starting point for the development of new lead molecules in the fight against multi-drug bacterial resistance.
authors.forename: Walcimar T
authors.initials: WT
authors.lastname: Vellasco
authors.forename: Guilherme P
authors.initials: GP
authors.lastname: Guedes
authors.forename: Victor
authors.initials: V
authors.lastname: Facchinetti
authors.forename: Thatyana R A
authors.initials: TR
authors.lastname: Vasconcelos
authors.forename: Maria G F
authors.initials: MG
authors.lastname: Vaz
authors.forename: Wilson
authors.initials: W
authors.lastname: Cunico
authors.forename: Marcus V N
authors.initials: MV
authors.lastname: de Souza
authors.forename: Geraldo R
authors.initials: GR
authors.lastname: de Paula
authors.forename: Maria E C K
authors.initials: ME
authors.lastname: Fleming
authors.affiliation: Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos - Farmanguinhos. Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, 21041-250, RJ, Brazil. claudiabrandao@far.fiocruz.br.
authors.forename: Claudia R B
authors.initials: CR
authors.lastname: Gomes
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013449:Sulfonamides