title: Transposition of the great arteries: factors influencing prenatal diagnosis.
abstract: OBJECTIVE
  The objective of this study is to highlight the factors that may affect prenatal diagnosis of transposition of the great arteries (TGA) in order to improve it.
  
  
  METHODS
  This is a retrospective study performed between 2004 and 2009 in the maternity units from North of France. We identified a total of 68 cases of TGA (isolated or associated with only VSD or coarctation of aorta), of which 32 (47.1%) had prenatal diagnosis (PND+) and 36 did not (PND-). Maternal characteristics and ultrasound factors were studied in relation to PND.
  
  
  RESULTS
  Maternal weight and body mass index were significantly higher in the PND- group (70.4 kg and 26.5 kg/m(2) vs 63.6 kg and 23.6 kg/m(2) , respectively). Maternal obesity (body mass index >30) was significantly more frequent in the PND- group (27.8% vs 12.5%). More than a quarter of TGA (28.1%) were diagnosed during the third trimester.
  
  
  CONCLUSIONS
  Obesity is the main cause of missed PND of TGA. Obese patients with suboptimal prenatal scans may benefit from reassessment of fetal cardiac anatomy and/or from referral for fetal echocardiography.
authors.affiliation: Department of Obstetrics, Jeanne de Flandre Hospital, CHU Lille, Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Bertagna
authors.forename: T
authors.initials: T
authors.lastname: Rakza
authors.forename: G
authors.initials: G
authors.lastname: Vaksmann
authors.forename: N
authors.initials: N
authors.lastname: Ramdane-Sebbane
authors.forename: L
authors.initials: L
authors.lastname: Devisme
authors.forename: L
authors.initials: L
authors.lastname: Storme
authors.forename: C
authors.initials: C
authors.lastname: Francart
authors.forename: P
authors.initials: P
authors.lastname: Vaast
authors.forename: V
authors.initials: V
authors.lastname: Houfflin-Debarge
mesh_terms: D000328:Adult; D015992:Body Mass Index; D004452:Echocardiography / Q000706:statistics & numerical data; D005260:Female; D005318:Fetal Heart / Q000000981:diagnostic imaging; D005602:France / Q000453:epidemiology; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000000981:diagnostic imaging / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000000981:diagnostic imaging / Q000453:epidemiology; D012189:Retrospective Studies; D014188:Transposition of Great Vessels / Q000000981:diagnostic imaging* / Q000453:epidemiology; D016216:Ultrasonography, Prenatal / Q000706:statistics & numerical data*; D055815:Young Adult