title: The relation between hepatitis C virus and coronary heart disease.
abstract: It is well known that chronic hepatitis C is associated with insulin resistance and metabolic syndrome which are risk factors for atherosclerosis and coronary heart disease. As a result, chronic hepatitis C might be thought, through its association with metabolic syndrome, to increase the risk of myocardial infarction. However, unexpectedly it was found that HCV infection is not associated with an increased risk of myocardial infarction. We are providing here an hypothesis of the mechanism through which HCV infection does not increase the risk for myocardial infarction and also may be protecting against some cardiovascular risks that typically develop in many patients with metabolic syndrome who do not have chronic hepatitis C. The suggested mechanism includes factors that are normal consequences of chronic hepatitis, such as: significant decrease in cholesterol and LDL levels; defected blood clotting system; impaired myocardial function; decreased venous return and central venous pressure; increased nitric oxide and TNF alpha levels; and diminished cardiac beta receptors signal transduction. All these factors contribute to a protective effect against cardiac ischemia and coronary heart disease. We suggest further studies to investigate this hypothesis.
authors.affiliation: Mansoura University, Mansoura, Egypt. Electronic address: amrhanym@gmail.com.
authors.forename: Amr Hany
authors.initials: AH
authors.lastname: Metwally
authors.affiliation: Mansoura University, Mansoura, Egypt.
authors.forename: Mohamed-Adel F
authors.initials: MA
authors.lastname: Elgamal
mesh_terms: D003327:Coronary Disease / Q000150:complications / Q000821:virology*; D048909:Diabetes Complications / Q000175:diagnosis; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D015994:Incidence; D024821:Metabolic Syndrome / Q000150:complications; D012307:Risk Factors