title: 18F-FDG PET/CT metabolic variability in functioning oncocytic parathyroid adenoma with brown tumors.
abstract: A 29-year-old female patient exhibited a solitary neck mass, severe hypercalcemia, and multiple skeletal lytic lesions consistent with metastatic neoplastic disease. Fine-needle aspiration (FNA) cytology of the neck lesion indicated a follicular thyroid neoplasm. CT-guided bone biopsy was non-diagnostic. Subsequent 18F-FDG PET/CT examination demonstrated avid glucose uptake within the neck mass and diffuse bony lesions of variable metabolic activity. Repeat biopsy utilizing PET/CT guidance produced core tissue with classic histologic features of a brown tumor. Postoperative histology revealed an exclusively oncocytic parathyroid adenoma. Atypical radiotracer uptake of this rare functioning adenoma subtype is illustrated with discussion of improved procedural diagnostic yield utilizing PET/CT.
authors.affiliation: From the Kettering Medical Center, Dayton, OH.
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Guy
authors.forename: Celine
authors.initials: C
authors.lastname: Jacob
authors.forename: Stephen D
authors.initials: SD
authors.lastname: McDonald
authors.forename: Yvonne G
authors.initials: YG
authors.lastname: Dowdy
authors.forename: Arash
authors.initials: A
authors.lastname: Kardan
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D064847:Multimodal Imaging; D010282:Parathyroid Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D019788:Fluorodeoxyglucose F18