title: [Part II. Scientific evidence in end-stage chronic organ failure. A position paper on shared care planning].
abstract: The therapeutic options related to chronic organ failure are interconnected to the variability of human biological responses and the personal history and choices of the chronically ill patient on one hand, and with the variable human answers to therapies on the other hand. All these aspects may explain the small number and low quality of studies aimed to define the clinical criteria useful in identifying end-stage chronically ill patients, as highlighted through the 2012-2013 Medline survey performed by the task force. These results prevented the grading of scientific evidence. However, taking into account the evidence based medicine definition, the task force believes the clinical reasoning and the individual experience of clinicians as well as the patients and families preferences cannot be replaced "tout court" with a strict methodological research. Accordingly, the working method selected by the task force members was to draw up a set of clinical parameters based on the available scientific literature, submitting it to a peer review process carried out by an expert panel. This paper discusses a set of clinical parameters included in the clinical decision-making algorithm and shared by nine medical societies. For each chronic organ failure these clinical parameters should be intended not as a rigid cutoff system to make a choice between two selected care options (intensive vs palliative), rather as the starting point for a joint and careful consideration regarding the opportunity to adopt the clinical decision-making algorithm care proposed in Part I.
authors.forename: Giuseppe R
authors.initials: GR
authors.lastname: Gristina
authors.forename: Luciano
authors.initials: L
authors.lastname: Orsi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Carlucci
authors.forename: Ignazio R
authors.initials: IR
authors.lastname: Causarano
authors.forename: Marco
authors.initials: M
authors.lastname: Formica
authors.forename: Massimo
authors.initials: M
authors.lastname: Romanò
mesh_terms: D000465:Algorithms; D002908:Chronic Disease / Q000628:therapy*; D003245:Consensus Statements as Topic; D003657:Decision Making; D019317:Evidence-Based Medicine; D006801:Humans; D033183:Interdisciplinary Communication; D007558:Italy; D009102:Multiple Organ Failure / Q000628:therapy; D012955:Societies, Medical; D013727:Terminal Care / Q000592:standards*
vernacular_title: Parte II. Evidenze scientifiche nelle insufficienze croniche d'organo "end-stage". Documento di consenso per una pianificazione condivisa delle scelte di cura.