title: A new class of red fluorescent organic nanoparticles: noncovalent fabrication and cell imaging applications.
abstract: Cyano-substituted diarylethlene derivatives R-OMe (-H, -CF3) with different peripheral substituted groups were synthesized in high yield. Water-soluble red fluorescent organic nanoparticles (FONs) could be facilely prepared from them via hydrophobic interaction with polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer (Pluronic F127). The optical properties and surface morphology of the synthesized FONs were characterized, and their biocompatibilities as well as their applications in cell imaging were further investigated. We demonstrate that such red FONs exhibit antiaggregation-caused quenching properties, broad excitation wavelengths, excellent water dispersibilities, and biocompatibilities, making them promising for cell imaging.
authors.affiliation: Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University , Beijing, 100084, P. R. China.
authors.forename: Xiqi
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Yaling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yen
authors.initials: Y
authors.lastname: Wei
mesh_terms: D002477:Cells / Q000737:chemistry*; D003584:Cytological Techniques / Q000295:instrumentation* / Q000379:methods; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes