title: Zwitterionic hyperbranched polyester functionalized cardiovascular stent and its biocompatibility.
abstract: Zwitterionic hyperbranched polyester (HBPE) synthesized on bare metal stents (BMS) surface by surface-initiated atom transfer radical polymerization (SI-ATRP) method. The modified BMS obtained was tested for its blood compatibility. The blood compatibility studies were including, platelet adhesion tests, hemolysis assay, morphological changes in RBCs, coagulation tests, PRT assay, complement activation, platelet activation, and the cytotoxicity was also investigated. The modified BMS surface does not cause platelets adherent, red blood cell disruption, hemolysis and does not induce complement and platelets activation. All results indicated that the modified BMS was blood compatible and no cytotoxicity. It has the potential use for biomedical applications.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Wang
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Miao
authors.affiliation: Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, PR China.
authors.forename: Xiaobao
authors.initials: X
authors.lastname: Shao
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China. Electronic address: maochun@njnu.edu.cn.
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China. Electronic address: jshen@njnu.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets; D004912:Erythrocytes; D057809:HEK293 Cells; D006801:Humans; D008422:Materials Testing; D010973:Platelet Adhesiveness; D011091:Polyesters / Q000737:chemistry*; D011817:Rabbits; D015607:Stents
chemical_list: D011091:Polyesters
keywords: Blood compatibility; Hyperbranched polyester; Zwitterion