title: Chemical composition and bioactivities of flavonoids-rich extract from Davallia cylindrica Ching.
abstract: The flavonoids profiles and bioactivities of flavonoids-rich extract from Davallia cylindrica Ching were investigated. The total flavonoids content in D. cylindrica was determined as about 164.41 mg/g. The main flavonoids in D. cylindrica were tentatively identified as quercetin-3-O-rutinoside, quercetin 7-O-glucoside, quercetin 7-O-glucoside, kaempferol 3-O-rutinoside, and quercitrin by UV and ESI-MS spectra. Flavonoids-rich extract (0.258 mg/ml) from D. cylindrica showed similar or higher free radical (O2(-), DPPH and ABTS) scavenging potential with that of rutin (0.25 mg/ml). The reducing power of flavonoids-rich extract (0.258 mg/ml) was slightly stronger than that of 0.25mg/ml rutin. The flavonoids extract from D. cylindrica exhibited cytotoxic effects on A549 cells. It exhibited a dose-dependent inhibition against acetylcholinesterase.
authors.affiliation: Department of Biology, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, PR China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Cao
authors.affiliation: Department of Biology, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, PR China.
authors.forename: Xian
authors.initials: X
authors.lastname: Xia
authors.affiliation: Department of Biology, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, PR China.
authors.forename: Xiling
authors.initials: X
authors.lastname: Dai
authors.affiliation: Department of Biology, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, PR China.
authors.forename: Quanxi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Biology, Shanghai Normal University, 100 Guilin Road, Shanghai 200234, PR China; Research Center of Engineering Technology for Extraction of Bioactive Compounds, Anhui Academy of Applied Technology, Suixi Road 312, 230031 Hefei, Anhui, PR China. Electronic address: jianboxiao@yahoo.com.
authors.forename: Jianbo
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000970:Antineoplastic Agents / Q000032:analysis / Q000494:pharmacology*; D000975:Antioxidants / Q000032:analysis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000032:analysis / Q000494:pharmacology*; D005419:Flavonoids / Q000032:analysis / Q000494:pharmacology*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism; D064028:Tracheophyta
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D010936:Plant Extracts; D013481:Superoxides; D000110:Acetylcholinesterase
keywords: Acetylcholinesterase inhibitor; Anticancer; Antioxidant; Davallia cylindrica; Flavonoids