title: Applications of C-H functionalization logic to cyclobutane synthesis.
abstract: The application of C-H functionalization logic to target-oriented synthesis provides an exciting new venue for the development of new and useful strategies in organic chemistry. In this article, C-H functionalization reactions are explored as an alternative approach to access pseudodimeric cyclobutane natural products, such as the dictazole and the piperarborenine families. The use of these strategies in a variety of complex settings highlights the subtle geometric, steric, and electronic effects at play in the auxiliary guided C-H functionalization of cyclobutanes.
authors.affiliation: Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Will R
authors.initials: WR
authors.lastname: Gutekunst
authors.forename: Phil S
authors.initials: PS
authors.lastname: Baran
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003503:Cyclobutanes / Q000138:chemical synthesis* / Q000737:chemistry; D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D010881:Piperidones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001688:Biological Products; D003503:Cyclobutanes; D026121:Indole Alkaloids; D010881:Piperidones; C550132:dictazole A; C570724:piperarborenine B