title: Anti-allergic inflammatory effects of cyanogenic and phenolic glycosides from the seed of Prunus persica.
abstract: A methanol extract of the seed of Prunus persica (Rosaceae) was found to inhibit histamine release in human mast cells. Activity-guided fractionation of the methanol extract yielded three cyanogenic glycosides (1-3) and other phenolic compounds (4-8). To evaluate their anti-allergic and anti-inflammatory activities, the isolates (1-8) were tested for their inhibitory effects on histamine release and on the gene expressions of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 in human mast cells. Of these, phenolic glycosides 7 and 8 suppressed histamine release and inhibited the pro-inflammatory cytokines TNF-alpha and IL-6. These results suggest that isolates from P. persica are among the anti-allergic inflammatory principles in this medicinal plant.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyungsan, Gyungbuk, 712-749 Korea. jkim6923@knu.ac.kr
authors.forename: Geum Jin
authors.initials: GJ
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Yeungnam University, Gyungsan, Gyungbuk, 712-749 Korea.
authors.forename: Hyun Gyu
authors.initials: HG
authors.lastname: Choi
authors.affiliation: College of Pharmacy, Yeungnam University, Gyungsan, Gyungbuk, 712-749 Korea.
authors.forename: Ji Hyang
authors.initials: JH
authors.lastname: Kim
authors.affiliation: School of Medicine, Kyungpook National University, Daegu, 702-701 Korea.
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701 Korea.
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.affiliation: College of Pharmacy, Yeungnam University, Gyungsan, Gyungbuk, 712-749 Korea.
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification*; D006027:Glycosides / Q000302:isolation & purification*; D006633:Histamine Antagonists / Q000302:isolation & purification*; D006801:Humans; D010636:Phenols / Q000302:isolation & purification*; D027861:Prunus / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D006027:Glycosides; D006633:Histamine Antagonists; D010636:Phenols; C007173:cyanogenic glycosides