title: Distal cholangiocarcinoma.
abstract: Distal cholangiocarcinoma is an uncommon malignancy and early diagnosis remains a challenge. More accurate diagnostic modalities for early-stage diagnosis are needed. Advances in medical therapy and neoadjuvant treatment may aid surgery and further improve postoperative outcomes. Margin-negative resection in conjunction with thorough nodal dissection is the strongest prognostic factor. Surgical resection coupled with adjuvant therapy provides the most favorable outcome. Future efforts should be aimed at reducing surgical complications and improving medical therapy, leading to overall improvement in perioperative and long-term outcomes for patients with this disorder.
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road, Northeast, Atlanta, GA 30322, USA.
authors.forename: Neha
authors.initials: N
authors.lastname: Lad
authors.affiliation: Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road, Northeast, Atlanta, GA 30322, USA. Electronic address: dkooby@emory.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Kooby
mesh_terms: D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000628:therapy; D001653:Bile Ducts, Intrahepatic / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000473:pathology* / Q000628:therapy; D006801:Humans
keywords: Distal cholangiocarcinoma; Neoadjuvant therapy; Nodal dissection; Surgical resection