title: Prognosis factors of pregnancy after intrauterine insemination with the husband's sperm: conclusions of an analysis of 2,019 cycles.
abstract: OBJECTIVE
  To identify the prognostic factors for pregnancy after intrauterine insemination with the husband's sperm (IUI-H).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  A single university medical center.
  
  
  METHODS
  851 couples, for 2,019 IUI-H cycles.
  
  
  METHODS
  After controlled ovarian stimulation, IUI-H performed 36 hours after ovulation triggering or 24 hours after a spontaneous luteinizing hormone (LH) surge.
  
  
  METHODS
  Clinical pregnancy rate per cycle (PR) and delivery rate per cycle (DR).
  
  
  RESULTS
  The overall PR was 14.8% and DR 10.8%. Higher PR and DR were observed for patients presenting with ovulation disorders (particularly polycystic ovary syndrome) or with male infertility. Secondary infertility in the woman appeared to be a positive prognostic factor as did a basal follicle-stimulating hormone (FSH) level ≤ 7 IU/L and ovulation triggering over spontaneous LH rise. The other parameters influencing the results were the women's age, the number of mature follicles obtained (≥ 2), the endometrial thickness (10-11 mm), and the number of progressive motile spermatozoa inseminated (>1 million).
  
  
  CONCLUSIONS
  In women aged ≤ 38 years, IUI-H should be considered as an option, particularly in cases of female infertility from ovulation disorders, in cases of a normal ovarian reserve, in cases of secondary infertility, or when ≥ 1 million progressive sperm are inseminated. Bifollicular stimulation is required. In other cases, in vitro fertilization should be discussed as the first-line treatment.
authors.affiliation: Department of Gynecology-Obstetric and Reproduction, Gynepôle, AP-HM La Conception, Marseille, France.
authors.forename: Laka
authors.initials: L
authors.lastname: Dinelli
authors.affiliation: Department of Gynecology-Obstetric and Reproduction, Gynepôle, AP-HM La Conception, Marseille, France; IMBE, Biogénotoxicologie, Santé Humaine & Environnement UMR 6116, Aix-Marseille Université, Marseille FR CNRS 3098, ECCOREV, Aix-en-Provence, France.
authors.forename: Blandine
authors.initials: B
authors.lastname: Courbière
authors.affiliation: Department of Gynecology-Obstetric and Reproduction, Gynepôle, AP-HM La Conception, Marseille, France; Department of Histology-Embryology, Faculty of Medicine, Aix-Marseille University, Marseille, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Achard
authors.affiliation: CIC-CPCET, Data Management and Biostatistics, AP-HM, Marseille, France.
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Jouve
authors.affiliation: Department of Gynecology-Obstetric and Reproduction, Gynepôle, AP-HM La Conception, Marseille, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Deveze
authors.affiliation: Department of Gynecology-Obstetric and Reproduction, Gynepôle, AP-HM La Conception, Marseille, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Gnisci
authors.affiliation: Department of Gynecology-Obstetric and Reproduction, Gynepôle, AP-HM La Conception, Marseille, France; Department of Histology-Embryology, Faculty of Medicine, Aix-Marseille University, Marseille, France.
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Grillo
authors.affiliation: Department of Gynecology-Obstetric and Reproduction, Gynepôle, AP-HM La Conception, Marseille, France; Department of Histology-Embryology, Faculty of Medicine, Aix-Marseille University, Marseille, France. Electronic address: odile.lacroix-paulmyer@ap-hm.fr.
authors.forename: Odile
authors.initials: O
authors.lastname: Paulmyer-Lacroix
mesh_terms: D000328:Adult; D017677:Age Distribution; D015897:Comorbidity; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data*; D005602:France / Q000453:epidemiology; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology* / Q000628:therapy*; D007317:Insemination, Artificial, Homologous / Q000706:statistics & numerical data*; D008875:Middle Aged; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D018873:Pregnancy Rate; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
keywords: Delivery rate; husband's sperm; intrauterine insemination; pregnancy rate; prognosis factor