title: Comparison of mean platelet volume in type 2 diabetics on insulin therapy and on oral hypoglycaemic agents.
abstract: BACKGROUND
  Increased mean platelet volume is a known risk factor for various acute vascular complications, which is commonly associated with patients with diabetes mellitus. This study was aimed to investigate the association of Mean Platelet Volume (MPV) with Type 2 Diabetes Mellitus (DM) and to know the difference of MPV in patients on oral hypoglycaemic drugs and insulin therapy.
  
  
  METHODS
  A total of 150 patients were selected and allocated to three Groups of 50 each, referred to as DM Group on insulin therapy, DM Group on oral hypoglycaemic therapy and non-DM Group (Negative control Group). Investigations like fasting blood glucose, HB A1c and MPV were performed. Difference between the means of age, MPV were calculated by analysis of variance (ANOVA) by using Tukey's Honestly Significant Difference (HSD) test. p-value and Confidence intervals were also calculated (p<0.05).
  
  
  RESULTS
  The outcome of study has shown that values of MPV are increased in patients with Type 2 DM, and are significantly higher in those patients on oral hypoglycaemic therapy than patients on insulin therapy.
  
  
  CONCLUSIONS
  MPV is a simple and cost-effective tool which can be explored for predicting the possibility of acute vascular events in patients suffering from diabetes mellitus. Values of MPV are increased in patients with uncontrolled Type 2 DM, and are significantly higher in diabetic patients treated with oral hypoglycaemic therapy than in those patients on insulin therapy. Early initiation of insulin treatment in confirmed cases of Type 2 diabetics not only helps in controlling blood glucose level but also helps in keeping MPV low and thereby preventing possibility of impending acute vascular events.
authors.affiliation: Associate Professor, Department of General Medicine, Srinivas Institute of Medical Science and Research Centre , Surathkal, Mangalore, India .
authors.forename: Pradeep V
authors.initials: PV
authors.lastname: Vernekar
authors.affiliation: Assistant Professor, Department of Pathology, Srinivas Institute of Medical Science and Research Centre , Surathkal, Mangalore, India .
authors.forename: Kuladeepa Ananda
authors.initials: KA
authors.lastname: Vaidya
keywords: Diabetes mellitus; Insulin therapy; Vascular