title: Antiangiogenic activity of flavonoids from Melia azedarach.
abstract: Three flavonoid glycosides, 1 (rutin: quercetin 3-O-rutinoside), 2 (kaempferol 3-O-robinobioside) and 3 (kaempferol 3-O-rutinoside) were isolated from the subcritical water extracts of Melia azedarach leaves. Strong antiangiogenic activity of these compounds was observed in the in vivo assay using the chorioallantoic membrane (CAM) from growing chick embryos.
authors.affiliation: Department of Food and Nutritional Sciences, University ofShizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. kumazawa@u-shizuoka-ken.ac.jp
authors.forename: Shigenori
authors.initials: S
authors.lastname: Kumazawa
authors.affiliation: Department of Food and Nutritional Sciences, University ofShizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors.forename: Satomi
authors.initials: S
authors.lastname: Kubota
authors.affiliation: Department of Food and Nutritional Sciences, University ofShizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors.forename: Haruna
authors.initials: H
authors.lastname: Yamamoto
authors.affiliation: Department of Food and Nutritional Sciences, University ofShizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Okamura
authors.affiliation: Bioorganic Chemistry Research Group, Faculty ofFisheries, Kagoshima University, 4-50-20 Shimoarata, Kagoshima 890-0056, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Sugiyamab
authors.affiliation: Bioorganic Chemistry Research Group, Faculty ofFisheries, Kagoshima University, 4-50-20 Shimoarata, Kagoshima 890-0056, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kobayashia
authors.affiliation: lnnovation and Joint Research Center, Shizuoka University, 3-5-1 Johoku, Naka-ku, Hamamatsu, Shizuoka 432-8561, Japan.
authors.forename: Motoyasu
authors.initials: M
authors.lastname: Nakanishi
authors.affiliation: Department of Food and Nutritional Sciences, University ofShizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Ohta
mesh_terms: D020533:Angiogenesis Inhibitors / Q000302:isolation & purification*; D000818:Animals; D002642:Chick Embryo; D044948:Flavonols / Q000302:isolation & purification*; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D031586:Melia azedarach / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D020533:Angiogenesis Inhibitors; D044948:Flavonols