title: Anti-thyroglobulin antibodies in differentiated thyroid carcinoma patients: Study of the clinical and biological parameters.
abstract: OBJECTIVE
  Detection of thyroglobulin in serum is of major clinical importance. The current assay techniques do not have all the qualifications which make the results of thyroglobulin difficult to interpret. The major problem is the autoantibody thyroglobulin (TgAb) interference. They induce an underestimation of thyroglobulin concentrations in the immunometric methods. We report in this study the clinical and biological parameters of anti-thyroglobulin antibodies of patients with differentiated thyroid carcinoma.
  
  
  METHODS
  A total of 246 patients with thyroid carcinomas were delicately selected from 2005 to 2012 in the nuclear medicine service of Tlemcen University hospital. Plasma thyroid stimulating hormone, thyroglobulin and anti-thyroglobulin antibodies were measured on Elecsys with the standardised Immunoradiometric assay.
  
  
  RESULTS
  We noticed that there is a rapid increase in the annual number of cases of thyroid carcinoma detected since 2007 with a much higher incidence in women. The rate of anti-thyroglobulin antibody interference reached 20.40%. The distribution of positive anti-thyroglobulin antibodies is not related to age or sex.
  
  
  CONCLUSIONS
  It is recommended to systematically measure anti-thyroglobulin antibodies, in parallel with the determination of thyroglobulin, using a sensitive method.
authors.affiliation: Laboratoire antibiotiques antifongiques : physico-chimie, synthèse et activité biologique, département de biologie moléculaire et cellulaire, faculté des sciences de la nature et de la vie, sciences de la terre et de l'univers, Tlemcen University, BP 119, Tlemcen 13000, Algeria. Electronic address: nagrah113@hotmail.com.
authors.forename: Mohammed Nadjib
authors.initials: MN
authors.lastname: Rahmoun
authors.affiliation: Laboratoire de médecine interne, centre hospitalier universitaire de Tlemcen, rue Khemis Mohamed V, Tlemcen 13000, Algeria.
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Bendahmane
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000097:blood* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002291:Carcinoma, Papillary / Q000097:blood* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D015592:Immunoradiometric Assay; D015994:Incidence; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D009363:Neoplasm Proteins / Q000097:blood*; D011933:Reagent Kits, Diagnostic; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D013954:Thyroglobulin / Q000097:blood* / Q000276:immunology; D013964:Thyroid Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000473:pathology; D013965:Thyroidectomy; D013972:Thyrotropin / Q000097:blood; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D009363:Neoplasm Proteins; D011933:Reagent Kits, Diagnostic; C006606:anti-thyroglobulin; D013972:Thyrotropin; D013954:Thyroglobulin