title: The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population.
abstract: BACKGROUND
  Omentin is an adipokine expressed predominantly in visceral adipose tissue, with adipose tissue stromal cells being the main source. Very little is known about the relationship between the genetic variability of the omentin gene and pathophysiology of obesity, although omentin is believed to play an important role in visceral obesity development. The aim of the study was to investigate two common polymorphisms in the omentin gene (rs2274908 and rs2274907) and dietary composition and anthropometric parameters of obesity in the Central European population.
  
  
  METHODS
  A total of 495 subjects were included into the study, they were further dividend into the non-obese, obese, and morbidly obese cohorts. Dietary habits were established using the 7-day food records and selected anthropometric parameters were measured.
  
  
  RESULTS
  There were significant differences in genotype distributions of rs2274907 between the obese and morbidly obese cohorts (P = 0.01). In the multivariate modelling, the rs2274907 polymorphism expressed independent prediction role for the daily energy intake, independently on the age and gender (P = 0.03); the TT genotype associated with the lowest (7877 ± 2780 J/day) and the AA genotype with the highest (8764 ± 2467 J/day) average energy intake. The rs2274907 also significantly associated with the daily consumption of fat and proteins.
  
  
  CONCLUSIONS
  This is, so far, the first study to investigate the polymorphisms in the omentin gene in a large population cohort of obese and non-obese individuals. Based on our results, the rs2274907 polymorphism is associated with the daily energy intake as well as daily intake of fat and protein.
authors.forename: Zbynek
authors.initials: Z
authors.lastname: Splichal
authors.forename: Julie
authors.initials: J
authors.lastname: Bienertova-Vasku
authors.forename: Jan
authors.initials: J
authors.lastname: Novak
authors.forename: Filip
authors.initials: F
authors.lastname: Zlamal
authors.forename: Josef
authors.initials: J
authors.lastname: Tomandl
authors.forename: Marie
authors.initials: M
authors.lastname: Tomandlova
authors.forename: Martin
authors.initials: M
authors.lastname: Forejt
authors.forename: Sona
authors.initials: S
authors.lastname: Havlenova
authors.forename: Aneta
authors.initials: A
authors.lastname: Jackowska
authors.forename: Anna
authors.initials: A
authors.lastname: Vasku
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D016207:Cytokines / Q000097:blood / Q000235:genetics*; D018153:Czech Republic; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake / Q000235:genetics*; D005247:Feeding Behavior; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000235:genetics; D005838:Genotype; D006801:Humans; D037102:Lectins / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D016207:Cytokines; D004041:Dietary Fats; D004044:Dietary Proteins; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins
keywords: Adipose tissue; Energy intake; Fat intake; Omentin; Val109Asp polymorphism