title: Contribution of baseline body mass index and leptin serum level to the prediction of early weight gain with atypical antipsychotics in schizophrenia.
abstract: OBJECTIVE
  This study investigated whether biochemical parameters add predictive information concerning risk for weight gain associated with treatment with atypical antipsychotics (AP) to that provided by baseline weight.
  
  
  METHODS
  Weight changes were assessed in 25 patients with schizophrenia after 3-6 months of treatment. These patients were started on AP monotherapy owing to a first psychotic episode or resumed treatment after at least a 6-month period of abandonment. Anthropometric and biochemical data were collected and analyzed as predictors of early weight change.
  
  
  RESULTS
  The baseline biochemical and anthropometric data were not significantly higher in the patients than in the healthy participants. During follow up, the patients had significant increases in body mass index and total cholesterol and apolipoprotein B level. The baseline weight and leptin level were predictive of weight gain during follow up, with an inverse association in both cases.
  
  
  CONCLUSIONS
  Baseline weight and leptin level may help to assess the risk of early weight gain with AP.
authors.affiliation: Psychiatry Service, University Hospital of Salamanca, Salamanca.
authors.forename: Benjamín
authors.initials: B
authors.lastname: Cortés
authors.forename: Joemir
authors.initials: J
authors.lastname: Bécker
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Mories Álvarez
authors.forename: Ana I Sánchez
authors.initials: AI
authors.lastname: Marcos
authors.forename: Vicente
authors.initials: V
authors.lastname: Molina
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015992:Body Mass Index; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D050177:Overweight / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D015430:Weight Gain / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D020738:Leptin
keywords: clozapine; leptin; olanzapine; risperidone; weight gain