title: Response to pneumococcal vaccination in mannose-binding lectin-deficient adults with recurrent respiratory tract infections.
abstract: Mannose-binding lectin (MBL)-deficiency is associated with an increased susceptibility to pneumococcal infections and other forms of disease. Pneumococcal vaccination is recommended in MBL-deficient patients with recurrent respiratory tract infections (RRTI). The response to pneumococcal vaccination in MBL-deficient individuals has not yet been studied in detail. An impaired response to pneumococcal polysaccharides in MBL-deficient patients might explain the association between MBL deficiency and pneumococcal infections. This study investigates the antibody response to pneumococcal vaccination in MBL-deficient adult patients with RRTI. Furthermore, we investigated whether there was a difference in clinical presentation between MBL-deficient and -sufficient patients with RRTI. Eighteen MBL-deficient and 63 MBL-sufficient adult patients with RRTI were all vaccinated with the 23-valent pneumococcal polysaccharide vaccine and antibodies to 14 pneumococcal serotypes were measured on a Luminex platform. There were no differences observed in the response to pneumococcal vaccination between MBL-sufficient and -deficient patients. Forty-three MBL-sufficient patients could be classified as responders to pneumococcal vaccination and 20 as low responders, compared to 15 responders and three low responders in the MBL-deficient patients. We found no clear difference in clinical, radiological, lung function and medication parameters between MBL-sufficient and -deficient patients. In conclusion, our study suggests that MBL-deficient adults with RRTI have a response to a pneumococcal capsular polysaccharide vaccine comparable with MBL-sufficient patients. Moreover, we did not find a clear clinical role of MBL deficiency in adults with RRTI. As MBL deficiency is associated with an increased susceptibility to pneumococcal infections, pneumococcal vaccination might be protective in MBL-deficient patients with RRTI.
authors.affiliation: Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, the Netherlands; Division of Heart and Lungs, University Medical Center, Utrecht, the Netherlands.
authors.forename: D A
authors.initials: DA
authors.lastname: van Kessel
authors.forename: T W
authors.initials: TW
authors.lastname: Hoffman
authors.forename: H
authors.initials: H
authors.lastname: van Velzen-Blad
authors.forename: P
authors.initials: P
authors.lastname: Zanen
authors.forename: G T
authors.initials: GT
authors.lastname: Rijkers
authors.forename: J C
authors.initials: JC
authors.lastname: Grutters
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D056724:Immunity, Humoral; D008297:Male; D037601:Mannose-Binding Lectin / Q000172:deficiency* / Q000276:immunology; D008661:Metabolism, Inborn Errors / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D010818:Practice Patterns, Physicians'; D012008:Recurrence; D012129:Respiratory Function Tests; D012141:Respiratory Tract Infections / Q000209:etiology / Q000276:immunology* / Q000517:prevention & control; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D037601:Mannose-Binding Lectin; D022242:Pneumococcal Vaccines
keywords: antibodies; immunodeficiency diseases; mannose binding lectin; pneumococcal vaccination