title: Regulation of interferon-dependent mRNA translation of target genes.
abstract: Interferons (IFNs) are released by cells on exposure to various stimuli, including viruses, double-stranded RNA, and other cytokines and various polypeptides. These IFNs play important physiological and pathophysiological roles in humans. Many clinical studies have established activity for these cytokines in the treatment of several malignancies, viral syndromes, and autoimmune disorders. In this review, the regulatory effects of type I and II IFN receptors on the translation-initiation process mediated by mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) pathways and the known mechanisms of control of mRNA translation of IFN-stimulated genes are summarized and discussed.
authors.affiliation: 1 Division of Hematology-Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School , Chicago, Illinois.
authors.forename: Barbara
authors.initials: B
authors.lastname: Kroczynska
authors.forename: Swarna
authors.initials: S
authors.lastname: Mehrotra
authors.forename: Ahmet Dirim
authors.initials: AD
authors.lastname: Arslan
authors.forename: Surinder
authors.initials: S
authors.lastname: Kaur
authors.forename: Leonidas C
authors.initials: LC
authors.lastname: Platanias
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism*; D007371:Interferon-gamma / Q000378:metabolism*; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D009369:Neoplasms / Q000276:immunology*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D053633:Receptor, Interferon alpha-beta / Q000378:metabolism*; D017471:Receptors, Interferon / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D007370:Interferon Type I; D012333:RNA, Messenger; D017471:Receptors, Interferon; C120411:interferon receptor, type II; D053633:Receptor, Interferon alpha-beta; D007371:Interferon-gamma; D058570:TOR Serine-Threonine Kinases; D019950:Mitogen-Activated Protein Kinase 1