title: Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.
abstract: OBJECTIVE
  To investigate the correlation among p300, CBP and MLL expression and the clinicopathological characteristics in resected SCLC patients.
  
  
  METHODS
  Two hundred and twenty-two resected SCLC patients were included in this study. We evaluated p300, CBP and MLL expression by immunohistochemistry.
  
  
  RESULTS
  Patients with high p300 expression had shorter OS and DFS than those with low p300 expression (p = 0.01; p = 0.009, respectively). The patients with CBP-positive tumors had significantly lower OS and DFS than those with CBP-negative tumors (p = 0.005 and p = 0.007, respectively). Moreover, the p300- and CBP-positive (+) group had a significantly poor OS and DFS. The multivariate Cox regression analysis showed that high p300 and CBP expression are independent markers of poor overall survival (p = 0.006; p = 0.017, respectively) in operable SCLC patients.
  
  
  CONCLUSIONS
  High p300 and CBP expression are independent prognostic markers of poor overall survival for resected SCLC patients. The combination of p300 and CBP expression may be useful in identifying patients with increased risks of cancer recurrence of SCLC.
authors.affiliation: Department of Pulmonary Medicine, The Third Affiliated Hospital of Harbin Medical University 150 Hapin Avenue, Nangang, Harbin, China.
authors.forename: Yina
authors.initials: Y
authors.lastname: Gao
authors.affiliation: Department of Pathology, The Third Affiliated Hospital of Harbin Medical University 150 Hapin Avenue, Nangang, Harbin, China.
authors.forename: Jingshu
authors.initials: J
authors.lastname: Geng
authors.affiliation: Department of Pulmonary Medicine, The Third Affiliated Hospital of Harbin Medical University 150 Hapin Avenue, Nangang, Harbin, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Hong
authors.affiliation: Department of Pathology, The First Affiliated Hospital of Harbin Medincal University Harbin, China.
authors.forename: Jiping
authors.initials: J
authors.lastname: Qi
authors.affiliation: Department of Pulmonary Medicine, The Third Affiliated Hospital of Harbin Medical University 150 Hapin Avenue, Nangang, Harbin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Teng
authors.affiliation: Department of Pulmonary Medicine, The Third Affiliated Hospital of Harbin Medical University 150 Hapin Avenue, Nangang, Harbin, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Pulmonary Medicine, The Second Affiliated Hospital of Harbin Medical University 150 Hapin Avenue, Nangang, Harbin, China.
authors.forename: Di
authors.initials: D
authors.lastname: Qu
authors.affiliation: Department of Pulmonary Medicine, The Third Affiliated Hospital of Harbin Medical University 150 Hapin Avenue, Nangang, Harbin, China.
authors.forename: Gongyan
authors.initials: G
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D050882:CREB-Binding Protein / Q000032:analysis*; D016009:Chi-Square Distribution; D018572:Disease-Free Survival; D050881:E1A-Associated p300 Protein / Q000032:analysis*; D005260:Female; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D051788:Myeloid-Lymphoid Leukemia Protein / Q000032:analysis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D055752:Small Cell Lung Carcinoma / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase; D050882:CREB-Binding Protein; C494363:CREBBP protein, human; D050881:E1A-Associated p300 Protein; C494360:EP300 protein, human
keywords: CBP; MLL; lung cancer; p300; prognosis; survival