title: Effect of isolated unilateral diaphragmatic paralysis on ventilation and exercise performance in rats.
abstract: The degree of impairment of ventilation and exercise performance after unilateral diaphragmatic paralysis (UDP) induced by phrenic nerve injury has been controversial due to heterogeneity in the published clinical studies. The aim of this study was to assess the effect of isolated UDP on breathing and exercise performance in conscious rats. Breathing was measured by unrestrained whole body plethysmography during quiet breathing and after moderate aerobic exercise. Additionally, incremental exercise testing was performed to evaluate the effects of intensive activity. The results demonstrated that complete UDP in rats resulted in a permanent decrease of peak inspiratory flow at rest breathing. Nevertheless, adequate ventilation could be maintained, and the breathing pattern was unaltered due to a strong compensatory mechanism and central re-coordination initiated by UDP. After being affected at an early stage, the ventilatory response to exercise was gradually regained and subsequently restored.
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, People's Republic of China; Department of Hand Surgery, The 3rd Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, People's Republic of China; Key Orthopaedic Biomechanics Laboratory of Hebei Province, People's Republic of China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Rui
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, People's Republic of China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, People's Republic of China.
authors.forename: Chengwei
authors.initials: C
authors.lastname: Xiao
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, People's Republic of China.
authors.forename: Qiyuan
authors.initials: Q
authors.lastname: Bao
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, People's Republic of China.
authors.forename: Jifeng
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Hand Surgery, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Key Laboratory of Hand Reconstruction, Ministry of Health, Shanghai, People's Republic of China; Shanghai Key Laboratory of Peripheral Nerve and Microsurgery, Shanghai, People's Republic of China. Electronic address: laojie633@sina.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Lao
mesh_terms: D000818:Animals; D005080:Exercise Test; D005260:Female; D001239:Inhalation / Q000502:physiology; D009043:Motor Activity / Q000502:physiology*; D010791:Phrenic Nerve / Q000293:injuries; D010993:Plethysmography, Whole Body; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function; D012119:Respiration; D012133:Respiratory Paralysis / Q000209:etiology / Q000503:physiopathology*; D013997:Time Factors
keywords: Exercise performance; Rat; Unilateral diaphragmatic paralysis; Ventilation