title: Mir-184 post-transcriptionally regulates SOX7 expression and promotes cell proliferation in human hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of the most common human malignancies and the third leading cause of cancer mortality worldwide. The development and progression of HCC is a complicated process, involving the deregulation of multiple genes that are essential to cell biological processes. Recently, microRNAs (miRNAs) have been suggested to be closely associated with tumorigenesis. Our study showed that miR-184 is upregulated in HCC cell lines and tissues. Overexpression of miR-184 in HCC cells increased cell proliferation, tumorigenicity, and cell cycle progression, whereas inhibition of miR-184 reduced cell proliferation, tumorigenicity, and cell cycle progression. Additionally, we identified SOX7 as a direct target of miR-184. Ectopic expression of miR-184 led to downregulation of the SOX7 protein, resulting in upregulation of c-Myc, Cyclin D1, and phosphorylation of Rb. Our findings suggested that miR-184 represents a potential onco-miR and plays an important role in HCC progression by suppressing SOX7 expression.
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.
authors.forename: Geng-Gang
authors.initials: GG
authors.lastname: Wu
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.
authors.forename: Wen-Hong
authors.initials: WH
authors.lastname: Li
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.
authors.forename: Wen-Guang
authors.initials: WG
authors.lastname: He
authors.affiliation: Liver Transplantation Center, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.affiliation: School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
authors.forename: Guang-Xian
authors.initials: GX
authors.lastname: Zhang
authors.affiliation: Department of Hepatopancreatobiliary Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Pathology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of TCM), Guangzhou, China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Yang
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.
authors.forename: Qi-Long
authors.initials: QL
authors.lastname: Liu
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.
authors.forename: Yan-Nian
authors.initials: YN
authors.lastname: Huang
authors.affiliation: Department of Clinical Laboratory, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Liver Transplantation Center, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of General Surgery, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China ; Department of Clinical Laboratory, Zengcheng People's Hospital (BoJi-Affiliated Hospital of Sun Yat-Sen University), Zengcheng, China.
authors.forename: Xian-Cheng
authors.initials: XC
authors.lastname: Zeng
mesh_terms: D001483:Base Sequence; D063646:Carcinogenesis / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002453:Cell Cycle / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D055760:SOXF Transcription Factors / Q000235:genetics*
chemical_list: C534424:MIRN184 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger; C484456:SOX7 protein, human; D055760:SOXF Transcription Factors