title: Evaluation of thermal neutron irradiation field using a cyclotron-based neutron source for alpha autoradiography.
abstract: It is important to measure the microdistribution of (10)B in a cell to predict the cell-killing effect of new boron compounds in the field of boron neutron capture therapy. Alpha autoradiography has generally been used to detect the microdistribution of (10)B in a cell. Although it has been performed using a reactor-based neutron source, the realization of an accelerator-based thermal neutron irradiation field is anticipated because of its easy installation at any location and stable operation. Therefore, we propose a method using a cyclotron-based epithermal neutron source in combination with a water phantom to produce a thermal neutron irradiation field for alpha autoradiography. This system can supply a uniform thermal neutron field with an intensity of 1.7×10(9) (cm(-2)s(-1)) and an area of 40mm in diameter. In this paper, we give an overview of our proposed system and describe a demonstration test using a mouse liver sample injected with 500mg/kg of boronophenyl-alanine.
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan. Electronic address: h-tanaka@rri.kyoto-u.ac.jp.
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakurai
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Masunaga
authors.affiliation: Sumitomo Heavy Industries, Ltd., Tokyo 141-6025, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Mitsumoto
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kinashi
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Narabayashi
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagawa
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fujimoto
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Maruhashi
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka 590-0494, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ono
mesh_terms: D000512:Alpha Particles; D001345:Autoradiography / Q000295:instrumentation*; D001895:Boron / Q000032:analysis*; D016754:Boron Neutron Capture Therapy / Q000295:instrumentation*; D017357:Cyclotrons / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007554:Isotopes / Q000032:analysis; D009502:Neutrons; D011829:Radiation Dosage; D011874:Radiometry / Q000295:instrumentation*; D012542:Scattering, Radiation
chemical_list: D007554:Isotopes; D001895:Boron
keywords: Alpha autoradiography; Boron neutron capture therapy; Cyclotron-based neutron source