title: Influence of bottle-feeding on serum bisphenol a levels in infants.
abstract: Exposure to endocrine disrupting chemicals (EDCs), particularly during developmental periods, gives rise to a variety of adverse health outcomes. Bisphenol A (BPA) is a well-known EDC commonly found in plastic products including food and water containers, baby bottles, and metal can linings. This study investigates infant exposure to BPA and the effect of bottle-feeding on serum BPA levels in infants. Serum BPA levels in normal healthy infants 6 to 15 months of age (n=60) were evaluated by a competitive ELISA. BPA was detected in every study sample. Serum BPA levels of bottle-fed infants (n=30) were significantly higher than those of breast-fed infants (n=30) (96.58±102.36 vs 45.53±34.05 pg/mL, P=0.014). There were no significant differences in serum BPA levels between boys (n=31) and girls (n=29). No significant correlations were found between serum BPA levels and age, body weight, birth weight, and gestational age. Bottle-feeding seems to increase the risk of infant exposure to BPA. Establishment of health policies to reduce or prevent BPA exposure in infants is necessary.
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Young-Jun
authors.identifier: 0000-0002-1250-6469
authors.initials: YJ
authors.lastname: Rhie
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Hyo-Kyoung
authors.identifier: 0000-0003-1512-2062
authors.initials: HK
authors.lastname: Nam
authors.affiliation: Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Yeon Joung
authors.identifier: 0000-0002-1664-8480
authors.initials: YJ
authors.lastname: Oh
authors.affiliation: Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Ho-Seong
authors.identifier: 0000-0003-1135-099X
authors.initials: HS
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, Korea University College of Medicine, Seoul, Korea.
authors.forename: Kee-Hyoung
authors.identifier: 0000-0002-4319-9019
authors.initials: KH
authors.lastname: Lee
mesh_terms: D001559:Benzhydryl Compounds / Q000097:blood*; D001724:Birth Weight; D001835:Body Weight; D001903:Bottle Feeding; D052244:Endocrine Disruptors / Q000097:blood*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010636:Phenols / Q000097:blood*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Baby Bottle; Bisphenol A; Bottle-Feeding; Endocrine Disrupting Chemical; Infant