title: Human papillomavirus status in extragenital nonmelanoma skin cancers.
abstract: About 5% of all cancers worldwide can be attributed to human papillomaviruses (HPVs); namely, six sites are strongly associated with HPV infections: cervix, penis, vulva, vagina, anus, and oropharynx. Nonmelanoma skin cancers (NMSC), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC) are the most common malignancies in Caucasians. In fact, there is an intense connection between sunlight exposure, fair skin, HPV, and development of NMSC. We have conducted a pilot study that included tissue samples from 26 carcinoma patients, of which there were 13 BCC and 13 SCC. HPV detection and typing was done with DNA amplification and sequencing, respectively. In total, 23.1% of SCC samples (3/13) and 7.7% of BCC samples (1/13) were positive for HPV DNA. The importance of understanding all aspects of NMSC carcinogenesis may be to reveal novel therapeutic options or preventive measures for HPV containing NMSC patients.
authors.affiliation: Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Salata 4, 10000 Zagreb, Croatia. Electronic address: dledic@kbc-zagreb.hr.
authors.forename: Daniela Ledic
authors.initials: DL
authors.lastname: Drvar
authors.affiliation: Croatian Academy of Medical Sciences, Praška 2, 10000 Zagreb, Croatia.
authors.forename: Jasna
authors.initials: J
authors.lastname: Lipozenčić
authors.affiliation: Department of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10000 Zagreb, Croatia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Sabol
authors.affiliation: Department of Dermatology and Venereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Salata 4, 10000 Zagreb, Croatia.
authors.forename: Zrinka Bukvic
authors.initials: ZB
authors.lastname: Mokos
authors.affiliation: Department of Pathology and Cytology, Zagreb University Hospital Center, and School of Medicine University of Zagreb, Kispaticeva 12, 10 000 Zagreb, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Ilic
authors.affiliation: Department of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka Cesta 54, 10000 Zagreb, Croatia.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Grce
mesh_terms: D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000473:pathology / Q000821:virology*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis*; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D010865:Pilot Projects; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology / Q000821:virology*
chemical_list: D004279:DNA, Viral