title: Varied clinical course of aplastic crisis in hereditary spherocytosis.
abstract: This study is the first to report a familial case involving differing clinical courses of aplastic crisis triggered by parvovirus B19 in two patients with HS, although similar eosin-5-maleimide-binding test and sodium dodecylsulfate-polyacrylamide gel electrophoresis results had been obtained for both. One patient had short-term mild symptoms, whereas the other patient developed severe anemia that required blood transfusion, experienced fever for 13 days, and did not have any rash. The severity of aplastic crisis is reported to be correlated with the severity of the underlying hemolytic anemia; the present findings show that the severity of infection should also be considered as an important predictive factor of the severity of aplastic crisis.
authors.affiliation: Department of Pediatrics, Kyoto-Katsura Hospital, Kyoto, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kataoka
authors.forename: Shoichi
authors.initials: S
authors.lastname: Doi
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Suemori
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nakanishi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Jonen
authors.forename: Mioko
authors.initials: M
authors.lastname: Mori
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Mizushima
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Wakazono
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis / Q000209:etiology*; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008297:Male; D012720:Severity of Illness Index; D013103:Spherocytosis, Hereditary / Q000150:complications* / Q000175:diagnosis
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007075:Immunoglobulin M
keywords: aplastic crisis; child; eosin-5-maleimide; hereditary spherocytosis; parvovirus B19