title: [Pro-angiogenic effects of four Chinese medicines and three herbal prescription in chicken chorioallantoic membrane model].
abstract: OBJECTIVE
  To observe the pro-angiogenic effect of four Chinese medicines and three herbal prescriptions, screen the effective components from them.
  
  
  METHODS
  Chicken chorioallantoic membrane (CAM) model was employed to observe the pro-angiogenic activities of Angelicae Sinensis Radix, Salviae Miltiorrhizae Radix, Notoginseng Radix, Astragali Radix, Xuefuzhuyu decoction, Dangguibuxue decoction and Taohongsiwu decoction, all of them were claimed to promote angiogenesis. The effective components were screened from the extracts.
  
  
  RESULTS
  Compared with negative control group, the blood vessel densities in Angelicae Sinensis Radix and Notoginseng Radix groups were not increased significantly (P > 0.05). However, blood vessel densities in Astragali Radix group, Salviae Miltiorrhizae Radix group, Xuefuzhuyu decoction group, Dangguibuxue decoction group and Taohongsiwu decoction group were notably enhanced (P < 0.05). Dangguibuxue decoction showed a more than 90% of increase in blood vessel densities as compared with the negative control group (P < 0.01), and components contained ferulic acid and astragaloside from Dangguibuxue decoction displayed significantly pro-angiogenic effect (P < 0.05).
  
  
  CONCLUSIONS
  Dangguibuxue decoction and its extract, components contained ferulic acid and astragaloside, can improve angiogenesis in CAM model significantly.
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi' an 710061, China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Dong
authors.affiliation: Shaanxi Pharmaceutical Development Center, Xi'an 710061, China.
authors.forename: Jian-Gang
authors.initials: JG
authors.lastname: Yang
authors.affiliation: Shaanxi Pharmaceutical Development Center, Xi'an 710061, China.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Xiao
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi' an 710061, China.
authors.forename: Wei-Yi
authors.initials: WY
authors.lastname: Feng
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi' an 710061, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Deng
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi' an 710061, China.
authors.forename: Li-Ting
authors.initials: LT
authors.lastname: Zhang
authors.affiliation: Department of Pharmacy, The First Affiliated Hospital, Medical College, Xi'an Jiaotong University, Xi' an 710061, China.
authors.forename: You-Xia
authors.initials: YX
authors.lastname: Wei
mesh_terms: D043925:Angiogenesis Inducing Agents; D000818:Animals; D027883:Astragalus Plant; D002645:Chickens; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects*; D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D029001:Herbal Medicine; D006801:Humans
chemical_list: D043925:Angiogenesis Inducing Agents; D003373:Coumaric Acids; D004365:Drugs, Chinese Herbal; C477279:danggui buxue decoction; C004999:ferulic acid