title: [Comparison of three different QuEChERS sample treatment methods in the analysis of more than one hundred pesticide residues in tobacco by gas chromatography-tandem mass spectrometry].
abstract: With a combination of QuEChERS method and gas chromatography-tandem mass spectrometry (GC-MS/MS) technique, three sample treatment methods (solvent exchange method, toluene dilution method, hexane liquid-liquid extraction method) were established to analyse more than one hundred pesticide residues in tobacco. The 155 pesticide analytes contained 58 organophosphorus, 28 organochlorine, 10 pyrethroids, 10 acyl amide, 11 carbamate, 7 dinitroaniline and 31 other family pesticides. Comparison of the three treatment methods was investigated on performances including matrix effect, co-extracted matrix, peak interference, recovery and the limit of quantification (LOQ). The hexane liquid-liquid extraction method gave the cleanest extract but poorer recovery; the solvent exchange and toluene dilution method could guarantee recoveries in the range of 70% and 120% for most of the 155 pesticides. We found that organophosphorus, acyl amide and carbamate pesticides exhibited relative strong matrix effects compared with organochlorine and pyrethroid pesticides. Toluene dilution method was recommended to analyse organophosphorus pesticides, and hexane liquid-liquid extraction (LLE) method was recommended to analyse organochlorine and pyrethroid pesticides.
authors.affiliation: China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
authors.forename: Xiaoshui
authors.initials: X
authors.lastname: Chen
authors.affiliation: China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Bian
authors.affiliation: China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.affiliation: China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Liu
authors.affiliation: China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
authors.forename: Gangling
authors.initials: G
authors.lastname: Tang
authors.affiliation: China National Tobacco Quality Supervision and Test Center, Zhengzhou 450001, China.
authors.forename: Qingyuan
authors.initials: Q
authors.lastname: Hu
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D059625:Liquid-Liquid Extraction; D010573:Pesticide Residues / Q000032:analysis*; D053719:Tandem Mass Spectrometry; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D010573:Pesticide Residues