title: Relationship between Birth Weight and Metabolic Status in Obese Adolescents.
abstract: Objective. To examine the relationships between birth weight and body mass index, percent body fat, blood lipids, glycemia, insulin resistance, adipokines, blood pressure, and endothelial function in a cohort of obese adolescents. Design and Methods. Ninety-five subjects aged 10-16 years (mean age 13.5 years) with a body mass index >95th centile (mean [±SEM] 33.0 ± 0.6) were utilized from two prospective studies for obesity prevention prior to any interventions. The mean term birth weight was 3527 ± 64 g (range 1899-4990 g;). Results. Body mass index z-score correlated positively with birth weight (r (2) = 0.05, P = 0.03), but not percent body fat. Insulin resistance negatively correlated with birth weight (r (2) = 0.05, P < 0.001), as did fasting plasma insulin (r (2) = 0.05, P < 0.001); both being significantly greater for subjects of small versus large birth weight (Δ Homeostasis Model Assessment = 2.5 and Δ insulin = 10 pmol/L for birth weight <2.5 kg versus >4.5 kg). Adiponectin, but not leptin, blood pressure z-scores or peripheral arterial tomography values positively correlated with birth weight (r (2) = 0.07, P = 0.008). Conclusions. Excess body mass index in obese adolescents was positively related to birth weight. Birth weight was not associated with cardiovascular risk factors but represented a significant determinant of insulin resistance.
authors.affiliation: London Health Sciences Centre, Lawson Health Research Institute, London, ON, Canada N6A 5W9 ; Lawson Health Research Institute, St Joseph's Health Care, 268 Grosvenor Street, London, ON, Canada N6A 4V2 ; Department of Paediatrics, University of Western Ontario, London, ON, Canada N6A 5A5 ; Department of Medicine, University of Western Ontario, London, ON, Canada N6A 5A5 ; Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5A5.
authors.forename: David J
authors.initials: DJ
authors.lastname: Hill
authors.affiliation: School of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5.
authors.forename: Harry
authors.initials: H
authors.lastname: Prapavessis
authors.affiliation: School of Kinesiology, University of Western Ontario, London, ON, Canada N6A 5A5.
authors.forename: J Kevin
authors.initials: JK
authors.lastname: Shoemaker
authors.affiliation: London Health Sciences Centre, Children's Hospital, London, ON, Canada N6A 5W9 ; Department of Pediatrics , University of Calgary, Calgary, Alberta, Canada.
authors.forename: Michelle
authors.initials: M
authors.lastname: Jackman
authors.affiliation: Department of Paediatrics, University of Toronto and Hospital for Sick Children, Toronto, ON, Canada M5G 1X8.
authors.forename: Farid H
authors.initials: FH
authors.lastname: Mahmud
authors.affiliation: London Health Sciences Centre, Lawson Health Research Institute, London, ON, Canada N6A 5W9 ; Department of Paediatrics, University of Western Ontario, London, ON, Canada N6A 5A5 ; London Health Sciences Centre, Children's Hospital, London, ON, Canada N6A 5W9.
authors.forename: Cheril
authors.initials: C
authors.lastname: Clarson