title: A model for computing genes governing marital dissolution through sentimental dynamics.
abstract: Adverse sentimental relationships that cause marital dissolution may involve a genetic component composed of genes from a couple, which interact with cultural, sociological, psychological and economic factors. However, the identification of these genes is very challenging. Here, we address this challenge by developing a computational model that can identify specific genes that impact on sentimental relationships of couples. The model was derived by implementing the second law of thermodynamics that quantifies sentimental relationships within a dynamic gene identification framework, called systems mapping. The model is equipped with a capacity to characterize and test the pattern of how genes from a couple interact with each other to determine the dynamic behavior of their marital relationships. The testing procedure is based on comparing genotypic differences in mathematical parameters of sentimental dynamics described by a group of ordinary differential equations (ODE). The model allows the test of individual parameters or a combination of parameters, addressing specific details related to martial relationships. The model may find its implications for designing an optimal effort policy and therapy to maintain a harmonic family in light of genetic blueprints of individual couples.
authors.affiliation: Center for Computational Biology, Beijing Forestry University, Beijing 100083, China.
authors.forename: Linghua
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Center for Computational Biology, Beijing Forestry University, Beijing 100083, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Center for Computational Biology, Beijing Forestry University, Beijing 100083, China.
authors.forename: Weimiao
authors.initials: W
authors.lastname: Wu
authors.affiliation: Department of Biostatistics, Yale University, New Haven, CT 06520, USA.
authors.forename: Zuoheng
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Division of Epidemiology, Department of Preventive Medicine, Stony Brook University Medical Center, Stony Brook, NY 11794, USA.
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.affiliation: Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA.
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhu
authors.affiliation: Center for Computational Biology, Beijing Forestry University, Beijing 100083, China; Center for Statistical Genetics, The Pennsylvania State University, Hershey, PA 17033, USA. Electronic address: rwu@phs.psu.edu.
authors.forename: Rongling
authors.initials: R
authors.lastname: Wu
mesh_terms: D019295:Computational Biology / Q000379:methods*; D003198:Computer Simulation; D004644:Emotions; D005191:Family Characteristics; D005260:Female; D005796:Genes; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008393:Marriage; D008957:Models, Genetic; D008962:Models, Theoretical; D040641:Quantitative Trait Loci / Q000235:genetics
keywords: Marital dissolution; Ordinary differentiation equations; Quantitative trait loci; Sentimental relationships; Systems mapping