title: [Thrombocytopenia].
abstract: Thrombocytopenia means low platelet count. This is the most frequent cause of bleeding abnormalities. Petechias, purpuras, mucosal bleeding are typical clinical findings. Severe, even life threatening gastrointestinal or intracranial bleeding may also occur. Diagnostic laboratory finding is the prolonged bleeding time. There are several causes of thrombocytopenia. The major mechanisms for a reduced platelet count are decreased production and increased destruction of platelets, or both. The major task is to reveal the underlying cause. Examination of the bone marrow and the peripheral blood smear can be helpful as well as special diagnostics of the assumed disease. Therapy targets the underlying disease, and also involves platelet transfusion. However, in case of diseases with increased platelet activation and consumption, platelet transfusion is contraindicated because it may lead to aggravation of the pathologic process.
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Belgyógyászati Klinika Budapest Korányi S. u. 2/A 1083.
authors.forename: Klára
authors.initials: K
authors.lastname: Gadó
authors.affiliation: Semmelweis Egyetem, Általános Orvostudományi Kar I. Belgyógyászati Klinika Budapest Korányi S. u. 2/A 1083.
authors.forename: Gyula
authors.initials: G
authors.lastname: Domján
mesh_terms: D001855:Bone Marrow Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis; D005260:Female; D017359:HELLP Syndrome / Q000175:diagnosis; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000175:diagnosis; D010976:Platelet Count; D011247:Pregnancy; D011696:Purpura, Thrombocytopenic / Q000175:diagnosis; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis; D013921:Thrombocytopenia / Q000097:blood* / Q000150:complications / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000175:diagnosis
keywords: bleeding disorders; bone marrow; csontvelő; gestation thrombocytopenia; immune-thrombocytopenia; immunthrombocytopenia; platelet; terhességi thrombocytopenia; thrombocytopenia; vérzékenység
vernacular_title: Thrombocytopeniák.