title: Solwaric acids A and B, antibacterial aromatic acids from a marine Solwaraspora sp.
abstract: Two novel trialkyl-substituted aromatic acids, solwaric acids A and B, were isolated from a marine Solwaraspora sp. cultivated from the ascidian Trididemnum orbiculatum. Solwaric acids A and B were isotopically labeled with U-¹³C glucose, and analysis of a ¹³C-¹³C COSY allowed for unambiguous determination of the location of the phenyl methyl group. The two novel compounds demonstrated antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA).
authors.affiliation: Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA. gaellis@wisc.edu.
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Ellis
authors.affiliation: Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA. twyche@wisc.edu.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Wyche
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, WI 53706, USA. fry@chem.wisc.edu.
authors.forename: Charles G
authors.initials: CG
authors.lastname: Fry
authors.affiliation: Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA. drbraun1@facstaff.wisc.edu.
authors.forename: Doug R
authors.initials: DR
authors.lastname: Braun
authors.affiliation: Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, WI 53705, USA. tbugni@pharmacy.wisc.edu.
authors.forename: Tim S
authors.initials: TS
authors.lastname: Bugni
mesh_terms: D000143:Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000143:Acids; D000900:Anti-Bacterial Agents