title: Clinical utility of fecal biomarkers for the diagnosis and management of inflammatory bowel disease.
abstract: Diagnosis and monitoring of inflammatory bowel diseases rely on clinical, endoscopic, and radiologic parameters. Inflammatory biomarkers have been investigated as a surrogate marker for endoscopic diagnosis of inflammatory activity. Fecal inflammatory biomarkers such as calprotectin and lactoferrin are direct products of bowel inflammation and provide an accurate and noninvasive diagnostic and monitoring modality for Crohn's disease and ulcerative colitis. This report contains an overview of the currently existing literature pertaining to clinical implications of fecal biomarkers for diagnosis, monitoring, and prediction of outcomes of inflammatory bowel disease.
authors.affiliation: *Division of Gastroenterology, McGill University Health Center, Montreal, Quebec, Canada; †Department of Medicine, McGill University, Montreal, Quebec, Canada; and ‡Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Uri
authors.initials: U
authors.lastname: Kopylov
authors.forename: Greg
authors.initials: G
authors.lastname: Rosenfeld
authors.forename: Brian
authors.initials: B
authors.lastname: Bressler
authors.forename: Ernest
authors.initials: E
authors.lastname: Seidman
mesh_terms: D015415:Biomarkers / Q000032:analysis; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D003424:Crohn Disease / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D018450:Disease Progression; D005243:Feces / Q000737:chemistry*; D006801:Humans; D007781:Lactoferrin / Q000032:analysis*; D039841:Leukocyte L1 Antigen Complex / Q000032:analysis*; D020782:Matrix Metalloproteinases / Q000032:analysis; D011237:Predictive Value of Tests; D011770:Pyruvate Kinase / Q000032:analysis; D012008:Recurrence; D009418:S100 Proteins / Q000032:analysis; D000067616:S100A12 Protein; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D039841:Leukocyte L1 Antigen Complex; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human; D011770:Pyruvate Kinase; D007781:Lactoferrin; D020782:Matrix Metalloproteinases