title: Histologic lichenoid features in oral dysplasia and squamous cell carcinoma.
abstract: OBJECTIVE
  This study describes the occurrence of histopathologic characteristics of oral lichenoid mucositis in epithelial dysplasia and squamous cell carcinoma.
  
  
  METHODS
  This retrospective review examined 352 histologic specimens of group 1 (mild to moderate dysplasia), group 2 (severe dysplasia or carcinoma in situ), and group 3 (squamous cell carcinoma) for correlation between 5 histologic characteristics frequently found in oral lichen planus and grade, age, gender, and oral subsite.
  
  
  RESULTS
  In this sample, 29% of all cases exhibited 3 or more lichenoid features. Lichenoid features were significantly more frequent in group 1 over group 2 lesions for cases meeting a minimum lichenoid threshold (P = .001). No statistically significant patterns were noted for age or gender. The buccal mucosa was significantly overrepresented (P = .039) and the floor of the mouth was significantly underrepresented (P = .049) in regard to lichenoid feature frequency.
  
  
  CONCLUSIONS
  This study confirms the frequent correlation of lichenoid characteristics in oral premalignant and malignant lesions.
authors.affiliation: Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA. Electronic address: sarah.fitzpatrick@case.edu.
authors.forename: Sarah G
authors.initials: SG
authors.lastname: Fitzpatrick
authors.affiliation: Department of Dermatology, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Kord S
authors.initials: KS
authors.lastname: Honda
authors.affiliation: Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Abdus
authors.initials: A
authors.lastname: Sattar
authors.affiliation: Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, School of Dental Medicine, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Hirsch
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies