title: Elevated expression of vascular endothelial growth factor (VEGF) 120 in parthenogenetic porcine placentas.
abstract: Most mammalian parthenogenetic embryos are unable to develop to term due to placental defects, potentially caused by decreased vasculogenesis and angiogenesis of the parthenogenetic placenta. Here we have compared the expression status of vascular endothelial growth factor (VEGF) and angiopoietin family members between normally developing and parthenogenetic porcine placentas. The result showed significantly reduced expression of these genes but elevated expression of VEGF 120 in the parthenogenetic porcine placenta (p < 0.05). We postulate that the abnormal expression levels of VEGF and angiopoietin family members and, especially, the elevated expression of VEGF 120 observed in parthenogenetic porcine placentas are related to the early miscarriage of parthenogenetic embryos in pigs.
authors.affiliation: Jilin Provincial Key Laboratory of Animal Embryo Engineering, College of Animal Science, Jilin University, 5333#, Xi'an Road, Changchun, 130062, China, hanyang_0008@163.com.
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.forename: Hongsheng
authors.initials: H
authors.lastname: Ouyang
authors.forename: Dongsheng
authors.initials: D
authors.lastname: Che
authors.forename: Xianju
authors.initials: X
authors.lastname: Chen
authors.forename: Yongye
authors.initials: Y
authors.lastname: Huang
authors.forename: I A
authors.initials: IA
authors.lastname: Elfaki elhag
authors.forename: Daxin
authors.initials: D
authors.lastname: Pang
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Li
mesh_terms: D042682:Angiopoietins / Q000032:analysis / Q000378:metabolism; D000818:Animals; D005260:Female; D018919:Neovascularization, Physiologic; D010312:Parthenogenesis / Q000502:physiology*; D010920:Placenta / Q000098:blood supply / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D013552:Swine; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis* / Q000378:metabolism
chemical_list: D042682:Angiopoietins; D042461:Vascular Endothelial Growth Factor A