title: Systemic stress signalling: understanding the cell non-autonomous control of proteostasis.
abstract: Proteome maintenance is crucial to cellular health and viability, and is typically thought to be controlled in a cell-autonomous manner. However, recent evidence indicates that protein-folding defects can systemically activate proteostasis mechanisms through signalling pathways that coordinate stress responses among tissues. Coordination of ageing rates between tissues may also be mediated by systemic modulation of proteostasis. These findings suggest that proteome maintenance is a systemically regulated process, a discovery that may have important therapeutic implications.
authors.affiliation: Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720, USA.
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Taylor
authors.affiliation: Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720, USA.
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Berendzen
authors.affiliation: Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Dillin
mesh_terms: D002470:Cell Survival; D016922:Cellular Senescence / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D020543:Proteome / Q000378:metabolism*; D015398:Signal Transduction; D013312:Stress, Physiological
chemical_list: D020543:Proteome