title: Lack of association of P2RX7 gene rs2230912 polymorphism with mood disorders: a meta-analysis.
abstract: BACKGROUND
  To assess the association of P2RX7 gene rs2230912 polymorphism with mood disorders using a meta-analysis.
  
  
  METHODS
  Data were collected from the following electronic databases: PubMed, Excerpta Medica Database, Elsevier Science Direct, Cochrane Library, and Chinese Biomedical Literature Database, with the last report up to April 1, 2013. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. Dependent on the results of heterogeneity test among individual studies, the fixed effect model (Mantel-Haenszel) or random effect model (DerSimonian-Laird) was selected to summarize the pooled OR.
  
  
  RESULTS
  We identified 13 separate studies using search (6,962 cases and 9,262 controls). We detected significant between-study heterogeneity. No significant association of this polymorphism with mood disorders was found (P>0.05). We also performed disease-specific meta-analysis in unipolar depression and bipolar disorder. No significant association of this polymorphism with unipolar depression or bipolar disorder was found (P>0.05). Additionally, we performed subgroup analysis by different types of cases. No significant association of this polymorphism with mood disorders in clinical cohorts or population-based cohorts (P>0.05). A significant association of this polymorphism with mood disorders was found for the allele contrast in family-based cohorts (OR = 1.26, 95%CI = 1.05-1.50, P = 0.01).
  
  
  CONCLUSIONS
  Overall, our meta-analysis suggests that P2RX7 gene rs2230912 polymorphism may not contribute to the risk of developing mood disorders using a case-control design. Given the discordance in the subgroup analysis by different types of cases, further studies based on larger sample size are still needed.
authors.affiliation: Department of Neurology, the affiliated Hospital of Shangluo Vocational and Technical College, Shangluo, China.
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Feng
authors.affiliation: Department of Neurology, Central Hospital of Shangluo, Shangluo, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.affiliation: Department of Neurology, Suzhou BenQ Hospital, the Affiliated Hospital of Nanjing Medical University, Suzhou, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Neurology, Central Hospital of Shangluo, Shangluo, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016014:Linear Models; D019964:Mood Disorders / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D058486:Receptors, Purinergic P2X7 / Q000235:genetics*; D015203:Reproducibility of Results
chemical_list: C546468:P2RX7 protein, human; D058486:Receptors, Purinergic P2X7