title: Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis.
abstract: Necrotizing enterocolitis is a disease entity with multiple proposed pathways of pathogenesis. Various combinations of these risk factors, perhaps based on genetic predisposition, possibly lead to the mucosal and epithelial injury that is the hallmark of NEC. Intestinal epithelial integrity is controlled by a tightly regulated balance between proliferation and differentiation of epithelium from intestinal epithelial stem cells and cellular loss by apoptosis. various signaling pathways play a key role in creating and maintaining this balance. The aim of this review article is to outline intestinal epithelial barrier development and structure and the impact of these inflammatory signaling and regulatory pathways as they pertain to the pathogenesis of NEC.
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Alabama at Birmingham, USA.
authors.forename: Jegen
authors.initials: J
authors.lastname: Kandasamy
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Alabama at Birmingham, USA.
authors.forename: Shehzad
authors.initials: S
authors.lastname: Huda
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Alabama at Birmingham, USA.
authors.forename: Namasivayam
authors.initials: N
authors.lastname: Ambalavanan
authors.affiliation: Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Alabama at Birmingham, USA. Electronic address: tjilling@peds.uab.edu.
authors.forename: Tamas
authors.initials: T
authors.lastname: Jilling
keywords: Crypts; Differentiation; Inflammation; Mucin; NEC; Necrotizing enterocolitis; Paneth cells; Secretory IgA; Signaling; Stem cells; Trefoil