title: Is paromomycin the drug of choice for eradication of Dientamoeba fragilis in adults?
abstract: Dientamoeba fragilis is a debated protozoan parasite that is often detected in stools of patients with chronic gastro-intestinal complaints. A retrospective follow-up study of a large cohort of patients was performed to better understand the natural course of the infection and possible treatment options. D. fragilis was spontaneously cleared in 41% of untreated cases. With an eradication rate of 98%, treatment with paromomycin appeared more effective than treatment with clioquinol (83%) or metronidazole (57%).
authors.affiliation: Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center and Harbor Hospital, Rotterdam, The Netherlands ; Laboratory for Parasitology, Harbor Hospital and Institute for Tropical Diseases, Rotterdam, The Netherlands.
authors.forename: Jaap J
authors.initials: JJ
authors.lastname: van Hellemond
authors.affiliation: Department of Internal Medicine, Harbor Hospital and Institute for Tropical Diseases, Rotterdam, The Netherlands.
authors.forename: Nicky
authors.initials: N
authors.lastname: Molhoek
authors.affiliation: Laboratory for Parasitology, Harbor Hospital and Institute for Tropical Diseases, Rotterdam, The Netherlands.
authors.forename: Rob
authors.initials: R
authors.lastname: Koelewijn
authors.affiliation: Department of Internal Medicine, Harbor Hospital and Institute for Tropical Diseases, Rotterdam, The Netherlands.
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: Wismans
authors.affiliation: Department of Internal Medicine, Harbor Hospital and Institute for Tropical Diseases, Rotterdam, The Netherlands.
authors.forename: Perry J J
authors.initials: PJ
authors.lastname: van Genderen
keywords: Diarrhea; Dientamoeba fragilis; Metronidazole; Parasite