title: Anticancer effects of human amniotic membrane and its epithelial cells.
abstract: Anticancer property of the amniotic membrane, the innermost layer of fetal membrane, was previously hypothesized. The recent reports confirmed the published hypotheses and developed new hypotheses in this context. Based on some evidences, it is hypothesized that inducing of apoptosis in cancer cells is originated from amniotic epithelial cells and cancer cell cycle arrest arises from amniotic mesenchymal cells. We also hypothesized here that apoptosis and cell cycle arrest in cancer cells induced by amniotic membrane arise from release of soluble factors from amniotic cells.
authors.affiliation: Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Nanomedicine and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: niknejad@sbmu.ac.ir.
authors.forename: Hassan
authors.initials: H
authors.lastname: Niknejad
authors.affiliation: Department of Tissue Engineering, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Ghasem
authors.initials: G
authors.lastname: Yazdanpanah
mesh_terms: D000650:Amnion / Q000166:cytology* / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry*; D017209:Apoptosis; D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D017077:Culture Media, Conditioned / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D008962:Models, Theoretical; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy*; D009389:Neovascularization, Pathologic
chemical_list: D000970:Antineoplastic Agents; D017077:Culture Media, Conditioned