title: Predictive biomarker candidates for the response of gastric cancer to targeted and cytotoxic agents.
abstract: Gastric cancer is the second most common cause of cancer death worldwide. Recent development of targeted agents provides clinicians with additional systemic treatment options to conventional cytotoxic agents. Predictive markers are undoubtedly important for guiding the appropriate use of targeted and cytotoxic agents. Currently, however, HER2 is the only predictive biomarker validated for gastric cancer. In this review, candidate predictive markers for response to other targeted agents and cytotoxic chemotherapeutic agents are discussed.
authors.affiliation: Center for Gastric Cancer, National Cancer Center, Goyang, 410-769, Republic of Korea. hkim@ncc.re.kr.
authors.forename: Hark Kyun
authors.initials: HK
authors.lastname: Kim
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Green
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D015415:Biomarkers; D003603:Cytotoxins / Q000008:administration & dosage; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics; D006801:Humans; D058990:Molecular Targeted Therapy; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000037:antagonists & inhibitors / Q000235:genetics; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D058570:TOR Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D003603:Cytotoxins; D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases; D051497:Receptor, Fibroblast Growth Factor, Type 2; D058570:TOR Serine-Threonine Kinases; C546842:MTOR protein, human; C512478:EGFR protein, human; C508053:ERBB2 protein, human; C496353:FGFR2 protein, human