title: Clinical and molecular epidemiology of community-onset invasive Staphylococcus aureus infection in New Zealand children.
abstract: Our aim was to describe the epidemiology and incidence of community-onset invasive S. aureus disease in children presenting to our hospital, and to compare the clonal complexes and virulence genes of S. aureus strains causing invasive and non-invasive disease. The virulence gene repertoire of invasive disease isolates was characterized using DNA microarray and compared with the virulence gene repertoire of non-invasive S. aureus isolates. Over the study period, 163 children had an invasive S. aureus infection. There was no difference in the distribution of clonal complexes or in the prevalence of genes encoding virulence factors between invasive and non-invasive isolates. Future research should include a strong focus on identifying the host and environmental factors that, along with organism virulence factors, are contributing to the patterns of invasive S. aureus disease observed in New Zealand.
authors.affiliation: Faculty of Medical and Health Sciences,University of Auckland,New Zealand.
authors.forename: D A
authors.initials: DA
authors.lastname: Williamson
authors.affiliation: Faculty of Medical and Health Sciences,University of Auckland,New Zealand.
authors.forename: S R
authors.initials: SR
authors.lastname: Ritchie
authors.affiliation: Department of Clinical Microbiology,Auckland District Health Board,New Zealand.
authors.forename: S A
authors.initials: SA
authors.lastname: Roberts
authors.affiliation: Australian Collaborating Centre for Enterococcus and Staphylococcus Species (ACCESS) Typing and Research, PathWest Laboratory Medicine, Perth,Australia.
authors.forename: G W
authors.initials: GW
authors.lastname: Coombs
authors.affiliation: Faculty of Medical and Health Sciences,University of Auckland,New Zealand.
authors.forename: M G
authors.initials: MG
authors.lastname: Thomas
authors.affiliation: Department of Statistics, NZIAS,Massey University,Albany,New Zealand.
authors.forename: O
authors.initials: O
authors.lastname: Hannaford
authors.affiliation: Department of Public Health,University of Otago,Wellington,New Zealand.
authors.forename: M G
authors.initials: MG
authors.lastname: Baker
authors.affiliation: Faculty of Medical and Health Sciences,University of Auckland,New Zealand.
authors.forename: D
authors.initials: D
authors.lastname: Lennon
authors.affiliation: Faculty of Medical and Health Sciences,University of Auckland,New Zealand.
authors.forename: J D
authors.initials: JD
authors.lastname: Fraser
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D003430:Cross-Sectional Studies; D005838:Genotype; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D046228:Microarray Analysis; D017720:Molecular Epidemiology; D058889:Molecular Typing; D009520:New Zealand / Q000453:epidemiology; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000473:pathology*; D013211:Staphylococcus aureus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D037521:Virulence Factors / Q000235:genetics
chemical_list: D037521:Virulence Factors