title: MDM2 SNP309 variation increases cervical cancer risk among Asians.
abstract: MDM2 T309G polymorphism has been suggested to be a risk factor for a number of cancers. The association of MDM2 T309G genetic variation with cervical cancer risk remains inconclusive. In the present study, we aimed to get a more confidential result by conducting a quantitative meta-analysis. Relevant literature up to October 2013 was searched and screened. Essential information was rigorously extracted for data pooling and analyzing, and then, separate analyses on ethnicity and source of controls were also performed. As a result, four articles including five case-control studies were selected. The overall data failed to show a significant association between MDM2 T309G polymorphism and cervical cancer risk (GG vs TT: odds ratio (OR)=1.31; 95 % confidence interval (CI)=0.55-3.13; dominant model: OR=1.22; 95 % CI=0.65-2.31; recessive model: OR=1.45; 95 % CI=0.79-2.65). However, in the subgroup analysis about ethnicity, increased cancer risk could be shown among Asians (GG vs TT: OR=2.15; 95 % CI=1.03-4.51; recessive model: OR=2.01; 95 % CI=1.32-3.06). In conclusion, the results of the present study suggest that homozygous GG alleles of MDM2 T309G polymorphism might be a risk factor for cervical cancer among Asians. Further studies are needed get a more definitive conclusion.
authors.affiliation: Department of Radiation Oncology, Chongqing Cancer Institute, Chongqing, China, zhuoxianlu@gmc.edu.cn.
authors.forename: Xianlu
authors.initials: X
authors.lastname: Zhuo
authors.forename: Jie
authors.initials: J
authors.lastname: Ren
authors.forename: Dairong
authors.initials: D
authors.lastname: Li
authors.forename: Yongzhong
authors.initials: Y
authors.lastname: Wu
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012306:Risk; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000235:genetics*
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2