title: der(5;17)(p10;q10) is a recurrent but rare whole-arm translocation in patients with hematological neoplasms: a report of three cases.
abstract: We report the cases of 3 patients with hematological malignancies and complex karyotypes involving der(5; 17) (p10;q10), which results in the loss of 5q and 17p. Although deletions of 5q and 17p are recurrent abnormalities in hematological disease, only about 20 cases harboring der(5; 17) (p10;q10) have been reported. We address the tumorigenesis and morphological characteristics of hematological malignancies involving der(5; 17)(p10;q10), along with a review of the literature.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Manabe
authors.forename: Junya
authors.initials: J
authors.lastname: Okita
authors.forename: Teruhito
authors.initials: T
authors.lastname: Tarakuwa
authors.forename: Naonori
authors.initials: N
authors.lastname: Harada
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Aoyama
authors.forename: Takeo
authors.initials: T
authors.lastname: Kumura
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Ohta
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Furukawa
authors.forename: Atsuko
authors.initials: A
authors.lastname: Mugitani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000754:Anemia, Refractory, with Excess of Blasts / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D000782:Aneuploidy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001854:Bone Marrow Cells / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002886:Chromosomes, Human, Pair 17 / Q000648:ultrastructure*; D002895:Chromosomes, Human, Pair 5 / Q000648:ultrastructure*; D000075202:Contraindications; D017809:Fatal Outcome; D005260:Female; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D059785:Karyotype; D000077269:Lenalidomide; D015477:Leukemia, Myelomonocytic, Chronic / Q000235:genetics / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000188:drug therapy; D008297:Male; D008533:Megakaryocytes / Q000648:ultrastructure; D009190:Myelodysplastic Syndromes / Q000235:genetics / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000473:pathology; D012008:Recurrence; D012074:Remission Induction; D013792:Thalidomide / Q000031:analogs & derivatives; D014178:Translocation, Genetic
chemical_list: D013792:Thalidomide; D000077269:Lenalidomide