title: [Treatment of pulmonary tuberculosis in a low-prevalence urban area. Compliance and sputum conversion].
abstract: Several factors could be responsible for a delay in bacteriological conversion of sputum in patients with pulmonary tuberculosis (pTB) even under proper treatment. We aimed to determine those factors associated with follow-up test compliance and bacteriologic conversion at month two of treatment in patients with pTB who were receiving directly controlled treatment (DOT) in an urban area with low TB burden (notification rate: 14.9 cases/100 000, 2010-2011). We retrospectively analyzed the clinical, demographic, radiological, microbiological and therapeutic characteristics of 196 new smear-positive pTB cases. The proportion of patients who underwent bacteriological examination was 79.1% (155/196) and 74.7% (121/162) at the second and last month of treatment. Smear examinations were significantly more frequent in patients with co-morbidities or receiving DOT in health facilities with laboratory access. Diabetes (OR 17.4, 95% CI 2.0 - 27.0) and high smear grade (OR 13.8, 95% CI 1.8 - 108.0) were highly associated with persistent positive smears. Cavitation (OR 4.6, 95%, CI 1.1 - 20.5) and diabetes (OR 3.3, 95% CI 1.1 - 10.5) were associated with persistent positive cultures. Smear examination results at two months of treatment indicated a sensitivity of 63.9% (23/36) and a specificity of 82.4% (98/119) in relation to culture. The limited predictive value of smear examination relative to culture results indicated the need to find other markers for sputum conversion. Identification of risk factors associated with persistent sputum positivity could contribute to patient care and resource allocation. Prolonged infectiousness in patients with diabetes could indicate the need to review TB control strategies.
authors.affiliation: Programa de Enfermedades Respiratorias y Tuberculosis de Santa Fe, Ministerio de Salud de la Provincia de Santa Fe, Argentina.
authors.forename: Carina
authors.initials: C
authors.lastname: Stoffel
authors.forename: Rosana
authors.initials: R
authors.lastname: Lorenz
authors.forename: Marta
authors.initials: M
authors.lastname: Arce
authors.forename: Marina
authors.initials: M
authors.lastname: Rico
authors.forename: Liliana
authors.initials: L
authors.lastname: Fernández
authors.forename: María S
authors.initials: MS
authors.lastname: Imaz
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D001118:Argentina / Q000453:epidemiology; D023801:Directly Observed Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013183:Sputum / Q000382:microbiology*; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D014504:Urban Health / Q000706:statistics & numerical data
chemical_list: D000995:Antitubercular Agents
keywords: bacteriological conversion; pulmonary tuberculosis; therapy
vernacular_title: Tratamiento de la tuberculosis pulmonar en un área urbana de baja prevalencia. Cumplimiento y negativización bacteriológica.