title: Dietary total and insoluble fiber intakes are inversely associated with prostate cancer risk.
abstract: Although experimental data suggest a potentially protective involvement of dietary fiber in prostate carcinogenesis, very few prospective studies have investigated the relation between dietary fiber intake and prostate cancer risk, and those have had inconsistent results. Our objective was to study the association between dietary fiber intake (overall, insoluble, soluble, and from different sources, such as cereals, vegetables, fruits, and legumes) and prostate cancer risk. Stratifications by excess weight status, insulin-like growth factors, and amount of alcohol intake were also considered. This prospective analysis included 3313 men from the Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort who completed at least 3 24-h dietary records. One hundred thirty-nine incident prostate cancers were diagnosed between 1994 and 2007 (median follow-up of 12.6 y). Associations between quartiles of energy-adjusted dietary fiber intake and prostate cancer risk were characterized by multivariate Cox proportional hazards models. Prostate cancer risk was inversely associated with total dietary fiber intake (HR of quartile 4 vs. quartile 1 = 0.47; 95% CI: 0.27, 0.81; P = 0.001), insoluble (HR = 0.46; 95% CI: 0.27, 0.78; P = 0.001), and legume (HR = 0.55; 95% CI: 0.32, 0.95; P = 0.04) fiber intakes. In contrast, we found no association between prostate cancer risk and soluble (P = 0.1), cereal (P = 0.7), vegetable (P = 0.9), and fruit (P = 0.4) fiber intakes. In conclusion, dietary fiber intake (total, insoluble, and from legumes but not soluble or from cereals, vegetables, and fruits) was inversely associated with prostate cancer risk, consistent with mechanistic data.
authors.affiliation: Sorbonne Paris Cité Research Center, Nutritional Epidemiology Research Team, U1153 National Institute of Health and Medical Research, U1125 National Institute for Agricultural Research, National Conservatory of Arts and Crafts, Paris 13 University, Bobigny, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Deschasaux
authors.forename: Camille
authors.initials: C
authors.lastname: Pouchieu
authors.forename: Mathilde
authors.initials: M
authors.lastname: His
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
authors.forename: Paule
authors.initials: P
authors.lastname: Latino-Martel
authors.forename: Mathilde
authors.initials: M
authors.lastname: Touvier
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D004043:Dietary Fiber / Q000008:administration & dosage / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D059012:Lost to Follow-Up; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000517:prevention & control*; D015203:Reproducibility of Results; D012306:Risk; D012995:Solubility