title: The expression profile of miR-23b is not altered in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies.
abstract: Idiopathic inflammatory myopathies (IIM) belong to a group of autoimmune disorders, primarily characterized by chronic inflammation of human skeletal muscle tissue. The etiology of these diseases is unknown, however, genetic predisposition plays a significant role in disease onset. Beside the known genetic risk located in the MHC complex, the epigenetic modifications including changes in miRNAs expression profiles have been recently implicated recently in many autoimmune diseases. Micro RNA molecules are involved in many physiological processes, including the regulation of the immune response. In our study we have focused on the miR-23b, as it represents a novel promising autoimmunity regulator molecule. Downregulation of miR-23b was recently described in patients with rheumatoid arthritis and systemic lupus erythematosus. We have measured the expression miR-23b peripheral blood mononuclear cells of patients with dermatomyositis and polymyositis. No meaningful difference was found in comparison with healthy controls.
authors.affiliation: Department of Rheumatology, First Faculty of Medicine, Charles University in Prague and Rheumatology Institute, Prague, Czech Republic.
authors.forename: Martina
authors.initials: M
authors.lastname: Remakova
authors.affiliation: Department of Experimental and Clinical Rheumatology, Institute of Rheumatology, Prague, Czech Republic.
authors.forename: Tana
authors.initials: T
authors.lastname: Svitalkova
authors.affiliation: Department of Experimental and Clinical Rheumatology, Institute of Rheumatology, Prague, Czech Republic.
authors.forename: Marek
authors.initials: M
authors.lastname: Skoda
authors.affiliation: Department of Experimental and Clinical Rheumatology, Institute of Rheumatology, Prague, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Vencovsky
authors.affiliation: Department of Experimental and Clinical Rheumatology, Institute of Rheumatology, Prague, Czech Republic.
authors.forename: Peter
authors.initials: P
authors.lastname: Novota