title: Pd-catalyzed nucleophilic fluorination of aryl bromides.
abstract: On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States.
authors.forename: Hong Geun
authors.initials: HG
authors.lastname: Lee
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Milner
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D008024:Ligands; D010165:Palladium / Q000737:chemistry*
chemical_list: D001965:Bromides; D006841:Hydrocarbons, Aromatic; D007454:Iodides; D008024:Ligands; D010165:Palladium