title: Double transfer of chirality in organocopper-mediated bis(alkylating) cycloisomerization of enediynes.
abstract: An original synthesis of chiral benzofulvenes triggered by organocopper reagents is reported. These enantiopure products are available through a highly chemo-, regio-, diastereo-, and enantioselective bis(alkylating) cycloisomerization process. A double chirality transfer (central-to-axial-to-central) is observed.
authors.affiliation: Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire UMR7273, 13390 Marseille (France).
authors.forename: Damien
authors.initials: D
authors.lastname: Campolo
authors.forename: Tanzeel
authors.initials: T
authors.lastname: Arif
authors.forename: Cyril
authors.initials: C
authors.lastname: Borie
authors.forename: Dominique
authors.initials: D
authors.lastname: Mouysset
authors.forename: Nicolas
authors.initials: N
authors.lastname: Vanthuyne
authors.forename: Jean-Valère
authors.initials: JV
authors.lastname: Naubron
authors.forename: Michèle P
authors.initials: MP
authors.lastname: Bertrand
authors.forename: Malek
authors.initials: M
authors.lastname: Nechab
keywords: alkynes; carbocycles; chirality; copper; cycloisomerization