title: Association of nuclear annexin A1 with prognosis of patients with esophageal squamous cell carcinoma.
abstract: Although recent progress has been made in the diagnosis and treatment of cancer, the prognosis of esophageal squamous cell carcinoma (ESCC) remains poor. The identification of biomarkers for ESCC prognosis is important for treatment decisions. The aim of this study was to evaluate the relationship between the expressions of Annexin A1 (ANXA1), three prime repair exonuclease 1 (TREX1) and apurinic/apyrimidinic endonuclease-1 (APE1) and clinical outcome of patients with ESCC. The expressions of ANXA1, TREX1 and APE1 in 93 pairs of ESCC and paracancerous tissues were tested using immunohistochemistry. ANX1, TREX1 and APE1 were dysregulated in ESCC. Nuclear expressions of ANXA1 and APE1 were significantly associated with pathologic type (P = 0.004 and 0.040, respectively). Patients with low expression of nuclear ANXA1 had a better prognosis than those with high expression of nuclear ANXA1 (HR = 0. 448, 95% CI 0.236-0.849, P = 0.014), especially for those with histologic grade 1 and 2 (HR = 0.303, 95% CI: 0.155-0.593, P < 0.001). In conclusion, nuclear ANXA1 may be potentially used as a prognostic biomarker for ESCC.
authors.affiliation: Department of Oncology, The Affiliated Second Hospital of Suzhou University Suzhou, Jiangsu, China ; Department of Oncology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Gaohua
authors.initials: G
authors.lastname: Han
authors.affiliation: Department of Oncology, The Affiliated Second Hospital of Suzhou University Suzhou, Jiangsu, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Tian
authors.affiliation: Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China ; National Engineering Center for Biochip at Shanghai Shanghai, China.
authors.forename: Bensong
authors.initials: B
authors.lastname: Duan
authors.affiliation: National Engineering Center for Biochip at Shanghai Shanghai, China.
authors.forename: Haihui
authors.initials: H
authors.lastname: Sheng
authors.affiliation: Institute of Digestive Disease, Department of Gastroenterology, Tongji Hospital, Tongji University Shanghai, China ; National Engineering Center for Biochip at Shanghai Shanghai, China.
authors.forename: Hengjun
authors.initials: H
authors.lastname: Gao
authors.affiliation: Department of Oncology, Taizhou People's Hospital Taizhou, Jiangsu, China.
authors.forename: Junxing
authors.initials: J
authors.lastname: Huang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017305:Annexin A1 / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D002467:Cell Nucleus / Q000737:chemistry*; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000032:analysis; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D000077277:Esophageal Squamous Cell Carcinoma; D005090:Exodeoxyribonucleases / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D010750:Phosphoproteins / Q000032:analysis; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D013997:Time Factors
chemical_list: D017305:Annexin A1; D014408:Biomarkers, Tumor; D010750:Phosphoproteins; D005090:Exodeoxyribonucleases; C429526:three prime repair exonuclease 1; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase
keywords: Annexin A1; apurinic/apyrimidinic endonuclease-1; esophageal squamous cell carcinoma; prognosis; three prime repair exonuclease 1