title: Analysis of hematopoiesis dynamics in residents of Techa riverside villages chronically exposed to nonuniform radiation: modeling approach.
abstract: A profound approach to the analysis of clinical data on the dynamics of major hematopoietic lineages (granulocytopoietic, thrombocytopoietic, and erythrocytopoietic systems) in chronically irradiated humans is proposed. It is based on recently developed mathematical models of these systems in humans, which enable one to study and interpret clinical hematological data. The developed approach is applied to the analysis of statistically processed clinical data, which were obtained under hematological examinations of residents of Techa riverside villages. These people were exposed to chronic irradiation with varying dose rate due to the radioactive contamination of the river basin by the Mayak Production Association. In the course of modeling studies, the relationship between the dynamics of aforementioned systems in examined individuals and the variation of chronic exposure dose rate over the considered period of time is revealed. It is found that the models are capable of reproducing common regularities and peculiarities of the dynamics of systems on hand, including the decreased stationary levels of blood cell concentrations during the period of maximum radiation exposure, the recovery processes during the period of decrease of exposure dose rate, and the prevalence of younger bone marrow granulocytopoietic cells over more mature ones during the entire period. The mechanisms of such effects of chronic irradiation on the hematopoietic lineages are revealed on the basis of modeling studies. All this testifies to the efficiency of employment of the developed models in the analysis, investigation, and prediction of effects of chronic irradiation on human hematopoietic system.
authors.affiliation: *Federal State Unitary Enterprise Research and Technical Center of Radiation-Chemical Safety and Hygiene, 40 Shchukinskaya St., Moscow, 123182, Russian Federation; †Urals Research Center for Radiation Medicine (URCRM), 68-a Vorovsky St., Chelyabinsk, 454076, Russian Federation.
authors.forename: O A
authors.initials: OA
authors.lastname: Smirnova
authors.forename: A V
authors.initials: AV
authors.lastname: Akleyev
authors.forename: G P
authors.initials: GP
authors.lastname: Dimov
mesh_terms: D001792:Blood Platelets / Q000528:radiation effects; D001854:Bone Marrow Cells / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004781:Environmental Exposure; D004912:Erythrocytes / Q000528:radiation effects; D006098:Granulocytes / Q000528:radiation effects; D006410:Hematopoiesis / Q000528:radiation effects*; D006801:Humans; D008962:Models, Theoretical; D011850:Radioactive Waste / Q000009:adverse effects; D045483:Rivers; D012426:Russia; D013326:Strontium Radioisotopes / Q000737:chemistry*; D014878:Water Pollution, Radioactive / Q000009:adverse effects
chemical_list: D011850:Radioactive Waste; D013326:Strontium Radioisotopes