title: Periconianone A, a new 6/6/6 carbocyclic sesquiterpenoid from endophytic fungus Periconia sp. with neural anti-inflammatory activity.
abstract: Periconianone A (1), a polyoxygenated sesquiterpenoid with a new 6/6/6 tricarbocyclic skeleton, and periconianone B (2) were isolated from the endophytic fungus Periconia sp. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction (Cu Kα). The biosynthesis of the unusual six-membered carbonic ring of 1 was postulated to be formed through intramolecular aldol condensation. Compounds 1 and 2 showed significant neural anti-inflammatory activity.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences , 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China.
authors.forename: Dewu
authors.initials: D
authors.lastname: Zhang
authors.forename: Hanlin
authors.initials: H
authors.lastname: Ge
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Zou
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Tao
authors.forename: Ridao
authors.initials: R
authors.lastname: Chen
authors.forename: Jungui
authors.initials: J
authors.lastname: Dai
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D008070:Lipopolysaccharides / Q000494:pharmacology; D051379:Mice; D017628:Microglia / Q000187:drug effects; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D012717:Sesquiterpenes; C000588725:periconianone A; C000588724:periconianone B; D009569:Nitric Oxide