title: Female sexual dysfunction in patients with major depressive disorder (MDD) treated with selective serotonin reuptake inhibitor (SSRI) and its association with serotonin 2A-1438 G/A single nucleotide polymorphisms.
abstract: BACKGROUND
  Selective serotonin reuptake inhibitors (SSRIs) are known for their sexual side effects. Different SSRIs may affect different areas of sexual function at different rates.
  
  
  OBJECTIVE
  The study aimed to determine the prevalence of female sexual dysfunction (FSD), its clinical correlates, and association with 5HT2A (rs6311) single nucleotide polymorphisms (SNPs) in patients with major depressive disorder (MDD) who were on SSRI therapy.
  
  
  METHODS
  This was a cross-sectional study on 95 female outpatients with MDD treated with SSRI. The patients were in remission as determined by Montgomery-Asberg Depression Rating Scale. Genomic DNA was isolated from buccal swabs and samples were processed using a real time polymerase chain reaction.
  
  
  METHODS
  The presence or absence of FSD as measured by the Malay Version of Female Sexual Function Index and 5HT2A-1438 G/A (rs6311) SNP.
  
  
  RESULTS
  The overall prevalence of FSD was 32.6%. After controlling for age, number of children, education level, total monthly income, SSRI types, and SSRI dosing, being employed significantly enhanced FSD by 4.5 times (odds ratio [OR] = 4.51; 95% confidence interval [CI] 1.00, 20.30; P = 0.05). Those having marital problems were 6.7 times more likely to have FSD (OR = 6.67; 95% CI 1.57, 28.34). 5HT2A-1438 G/A (rs6311) SNP was not significantly associated with FSD.
  
  
  CONCLUSIONS
  There was no significant association between FSD and the 5HT2A (rs6311) SNP in patients with MDD on SSRI therapy. Employment status and marital state were significantly associated with FSD among these patients.
authors.affiliation: Department of PsychiatryUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia.
authors.forename: Ruziana
authors.initials: R
authors.lastname: Masiran
authors.affiliation: Department of PsychiatryUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia.
authors.forename: Hatta
authors.initials: H
authors.lastname: Sidi
authors.affiliation: Department of PharmacologyUniversity of MalayaKuala LumpurMalaysia.
authors.forename: Zahurin
authors.initials: Z
authors.lastname: Mohamed
authors.affiliation: Department of PharmacologyUniversity of MalayaKuala LumpurMalaysia.
authors.forename: Nur Elia
authors.initials: NE
authors.lastname: Mohd Nazree
authors.affiliation: Department of PsychiatryUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia.
authors.forename: Nik Ruzyanei
authors.initials: NR
authors.lastname: Nik Jaafar
authors.affiliation: Department of PsychiatryUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia.
authors.forename: Marhani
authors.initials: M
authors.lastname: Midin
authors.affiliation: Department of AnatomyUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia.
authors.forename: Srijit
authors.initials: S
authors.lastname: Das
authors.affiliation: Department of PsychiatryUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia. Electronic address: suriati.saini@yahoo.com.my.
authors.forename: Suriati
authors.initials: S
authors.lastname: Mohamed Saini
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics; D004651:Employment; D005260:Female; D006801:Humans; D017533:Marital Status; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D012735:Sexual Dysfunction, Physiological / Q000235:genetics / Q000523:psychology*; D020018:Sexual Dysfunctions, Psychological / Q000235:genetics / Q000523:psychology*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D017367:Selective Serotonin Reuptake Inhibitors
keywords: 5HT2A Polymorphisms; Female Sexual Dysfunction; Major Depressive Disorder; SSRI-Induced Female Sexual Dysfunction; Selective Serotonin Reuptake Inhibitor Antidepressant Treatment; Serotonin 2A Polymorphisms