title: [To answer rare cancer issues. Geographical analysis of EMS sarcoma cohort in the Rhône-Alpes region].
abstract: Rare cancer issues have not been much explored yet because of their low incidence. That is why epidemiological studies have difficulties in identifying indisputable etiological risk factors. An expert opinion, mainly concentrated in some establishments, is required for these cancers' management. However, on account of the potential remoteness of these therapeutic resources, the patients' way of care remains also unstudied. By means of a geographical analysis of a regional exhaustive cohort of sarcoma, diagnosed in 2006 and 2007 and followed during five years at least, we can make progress on these different issues. Gastro-Intestinal and Stromal Tumors (GIST) occur more frequently in privileged territories while liposarcomas arise in more deprived areas. The association between liposarcomas and areas deprivation is significant (P=0.05). Moreover, pre-operative biopsy and some clinical patient characteristics, age, grade or tumor localization, are associated with an increase in the distance covered by patients for the first-line treatment (p ≤ 0,001). In the scope of an interdisciplinary collaboration, the geographical approach develops some hypothesis for rare cancers research, which must be tested by other larger scale studies.
authors.affiliation: Université Jean-Moulin Lyon 3, EA « Santé Individu Société », 18, rue Chevreul 69007 Lyon, France, Centre Léon-Bérard Lyon, EA « Santé Individu Société », 28, rue Laënnec, 69008 Lyon, France.
authors.forename: Yohan
authors.initials: Y
authors.lastname: Fayet
authors.affiliation: Université Jean-Moulin Lyon 3, EA « Santé Individu Société », 18, rue Chevreul 69007 Lyon, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Chasles
authors.affiliation: Centre Léon-Bérard Lyon, EA « Santé Individu Société », 28, rue Laënnec, 69008 Lyon, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Ducimetière
authors.affiliation: Institut de cancérologie Lucien-Neuwirth, 108 bis, av. Albert-Raimond, 42270 Saint-Priest en-Jarez, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Collard
authors.affiliation: Association du registre des rancers de l'enfant de la région Rhône-Alpes, CHU Hôpital Nord, 42055 Saint-Étienne cedex 2, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Berger
authors.affiliation: Centre Léon-Bérard Lyon, 28 rue Laënnec, 69008 Lyon, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Meeus
authors.affiliation: Centre Léon-Bérard Lyon, 28 rue Laënnec, 69008 Lyon, France.
authors.forename: Dominique
authors.initials: D
authors.lastname: Ranchère-Vince
authors.affiliation: Centre Léon-Bérard Lyon, 28 rue Laënnec, 69008 Lyon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Thiesse
authors.affiliation: Centre Léon-Bérard Lyon, 28 rue Laënnec, 69008 Lyon, France.
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Sunyach
authors.affiliation: Centre Léon-Bérard Lyon, 28 rue Laënnec, 69008 Lyon, France.
authors.forename: Perrine
authors.initials: P
authors.lastname: Marec-Bérard
authors.affiliation: Centre Léon-Bérard Lyon, 28 rue Laënnec, 69008 Lyon, France, Institut de Santé publique, université nationale Yang-Ming, No 155, Sec. 2, Linong Street, Taipei, Taiwan.
authors.forename: Lorraine
authors.initials: L
authors.lastname: Poncet
authors.affiliation: Centre Léon-Bérard Lyon, 28 rue Laënnec, 69008 Lyon, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Cousin
authors.affiliation: Centre Léon-Bérard Lyon, 28 rue Laënnec, 69008 Lyon, France.
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Blay
authors.affiliation: Centre Léon-Bérard Lyon, EA « Santé Individu Société », 28, rue Laënnec, 69008 Lyon, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Ray-Coquard
mesh_terms: D000328:Adult; D000368:Aged; D005602:France / Q000453:epidemiology; D046152:Gastrointestinal Stromal Tumors / Q000453:epidemiology* / Q000473:pathology; D062306:Geography, Medical; D006801:Humans; D008080:Liposarcoma / Q000453:epidemiology* / Q000473:pathology; D008875:Middle Aged; D035583:Rare Diseases / Q000453:epidemiology* / Q000473:pathology
keywords: cancer management; epidemiology; geography; rare cancers; sarcoma
vernacular_title: Répondre aux enjeux des cancers rares. Approche géographique de la cohorte EMS des sarcomes en région Rhône-Alpes.