title: Association of biomarkers of inflammation with dyslipidemia and its components among Mongolians in China.
abstract: OBJECTIVE
  This study aims to examine the association between inflammatory biomarkers and dyslipidemia and its components among Mongolians in China.
  
  
  METHODS
  Data were obtained from 2544 Mongolians via standard questionnaires and blood samples in Inner Mongolia, China. High sensitivity C-reactive protein (hsCRP), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble E-selectin (sE-selectin) as well as blood lipids were examined.
  
  
  RESULTS
  Individuals with dyslipidemia had higher levels of hsCRP, sICAM-1 and sE-selectin than those without dyslipidemia (all P values<0.001). Compared to the lowest quartile of inflammatory biomarkers, individuals with the highest quartile were more likely to have dyslipidemia (odds ratio, 95% confidence interval: 3.215, 2.551-4.116 for hsCRP; 1.575, 1.253-1.980 for sICAM-1; 1.495, 1.193-1.873 for sE-selectin). Moreover, hsCRP was associated with all the components of dyslipidemia, whereas, sICAM-1 was not related to high density lipoprotein cholesterol (HDL-c) or triglycerides (TAG). Additionally, sE-selectin was just associated with TAG.
  
  
  CONCLUSIONS
  Our study indicated that elevated plasma levels of hsCRP, sICAM-1 and sE-selectin were positively and significantly associated with increased risk of dyslipidemia among Mongolians. However, the associations were not identical for different inflammatory biomarkers with the components of dyslipidemia.
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Lingyan
authors.initials: L
authors.lastname: Tang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Peng
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Xu
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Aili
authors.initials: A
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China ; Department of Health Care, Xiamen Maternal and Child Care Hospital, Xiamen, Fujian, China.
authors.forename: Guiyan
authors.initials: G
authors.lastname: Wang
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Tong
authors.affiliation: Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu, China.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology*; D019040:E-Selectin / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D016015:Logistic Models; D008986:Mongolia / Q000208:ethnology; D016017:Odds Ratio; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein