title: The role of prostatic inflammation biomarkers in the diagnosis of prostate diseases.
abstract: Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are chronic conditions, which are hormone-dependent and epidemiologically associated with prostate inflammation. As a large number of studies have demonstrated, the stimulation of T-cells at the level of prostatic chronic inflammatory infiltrates is followed by stromal and epithelial cell proliferation. The aim of this review is to present the actual level of knowledge in the field of prostatic immune response and chronic inflammation, and to analyze the relationships between chronic inflammation and BPH/PCa. The most studied prostatic inflammation biomarkers detected in biological fluids are also presented, together with their potential roles in the diagnosis and prognosis of prostatic disease.
authors.affiliation: Department of Urology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania. Electronic address: razvan.bardan@gmail.com.
authors.forename: Razvan
authors.initials: R
authors.lastname: Bardan
authors.affiliation: Department of Biochemistry, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Raluca
authors.initials: R
authors.lastname: Dumache
authors.affiliation: Department of Pathology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Alis
authors.initials: A
authors.lastname: Dema
authors.affiliation: Department of Urology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Alin
authors.initials: A
authors.lastname: Cumpanas
authors.affiliation: Department of Urology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
authors.forename: Viorel
authors.initials: V
authors.lastname: Bucuras
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002908:Chronic Disease; D006801:Humans; D008297:Male; D011470:Prostatic Hyperplasia / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D011472:Prostatitis / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor
keywords: Benign prostatic hyperplasia; Biomarkers; Chronic inflammation; Prostate cancer