title: Normal weight estonian prepubertal boys show a more cardiovascular-risk-associated adipose tissue distribution than austrian counterparts.
abstract: Objective. Risk phenotypes for cardiovascular disease (CVD) differ markedly between countries, like the reported high difference in CVD mortality in Austria and Estonia. Hitherto, the goal of this study was to find out risk profiles in body fat distribution yet present in childhood, paving the way for later clinical end points. Methods. he subcutaneous adipose tissue (SAT) distribution patterns in 553 Austrian (A) and Estonian (E) clinically healthy normal weight boys aged 11.1 (±0.8) years were analysed. We applied the patented optical device Lipometer which determines the individual subcutaneous adipose tissue topography (SAT-Top). Results. Total body fat did not differ significantly between E and A boys. A discriminant analysis using all Lipometer data, BMI, and the total body fat (TBF) yielded 84.6% of the boys correctly classified in Estonians and Austrians by 9 body sites. A factor analysis identified the SAT distribution of E as critically similar to male adult patients with coronary heart disease (CHD). Conclusions. We show in normal weight Estonian boys a highly significant decreased fat accumulation on the lower body site compared to age matched Austrian males. This SAT-Top phenotype may play an important role for the increased cardiovascular risk seen in the Estonian population.
authors.affiliation: Center of Molecular Medicine, Institute of Pathophysiology and Immunology, Medical University of Graz, Heinrichstraße 31a, 8010 Graz, Austria.
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Wallner-Liebmann
authors.affiliation: Center of Physiological Medicine, Institute of Physiological Chemistry, University of Graz, 8010 Graz, Austria.
authors.forename: Reinhard
authors.initials: R
authors.lastname: Moeller
authors.affiliation: Center of Physiological Medicine, Institute of Physiological Chemistry, University of Graz, 8010 Graz, Austria.
authors.forename: Renate
authors.initials: R
authors.lastname: Horejsi
authors.affiliation: Faculty of Exercise and Sports Sciences, Center of Behavioural and Health Sciences, University of Tartu, 50090 Tartu, Estonia.
authors.forename: Toivo
authors.initials: T
authors.lastname: Jürimäe
authors.affiliation: Faculty of Exercise and Sports Sciences, Center of Behavioural and Health Sciences, University of Tartu, 50090 Tartu, Estonia.
authors.forename: Jaak
authors.initials: J
authors.lastname: Jürimäe
authors.affiliation: Faculty of Exercise and Sports Sciences, Center of Behavioural and Health Sciences, University of Tartu, 50090 Tartu, Estonia.
authors.forename: Jarek
authors.initials: J
authors.lastname: Mäestu
authors.affiliation: Faculty of Exercise and Sports Sciences, Center of Behavioural and Health Sciences, University of Tartu, 50090 Tartu, Estonia.
authors.forename: Priit
authors.initials: P
authors.lastname: Purge
authors.affiliation: Faculty of Exercise and Sports Sciences, Center of Behavioural and Health Sciences, University of Tartu, 50090 Tartu, Estonia.
authors.forename: Meeli
authors.initials: M
authors.lastname: Saar
authors.affiliation: Center of Physiological Medicine, Institute of Physiological Chemistry, University of Graz, 8010 Graz, Austria.
authors.forename: Erwin
authors.initials: E
authors.lastname: Tafeit
authors.affiliation: Center of Molecular Medicine, Institute of Pathophysiology and Immunology, Medical University of Graz, Heinrichstraße 31a, 8010 Graz, Austria.
authors.forename: Petra
authors.initials: P
authors.lastname: Kaimbacher
authors.affiliation: Center of Molecular Medicine, Institute of Pathophysiology and Immunology, Medical University of Graz, Heinrichstraße 31a, 8010 Graz, Austria.
authors.forename: Renate
authors.initials: R
authors.lastname: Kruschitz
authors.affiliation: Department of Pediatrics, Paracelsus Private Medical University of Salzburg, 5020 Salzburg, Austria.
authors.forename: Daniel
authors.initials: D
authors.lastname: Weghuber
authors.affiliation: Practice for General Internal Medicine, Bruck a.d.M., 8600 Graze, Austria.
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Schnedl
authors.affiliation: Clinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University of Graz, 8010 Graz, Austria.
authors.forename: Harald
authors.initials: H
authors.lastname: Mangge