title: Azole-resistant Aspergillus fumigatus isolate with the TR34/L98H mutation in both a fungicide-sprayed field and the lung of a hematopoietic stem cell transplant recipient with invasive aspergillosis.
abstract: A French farmer developed invasive aspergillosis with azole-resistant Aspergillus fumigatus with the TR34/L98H mutation following a hematopoietic stem cell transplantation. He had worked in fungicide-sprayed fields where a non-genetically related A. fumigatus TR34/L98H isolate was collected. If azole resistance detection increases, voriconazole as first-line therapy might be questioned in agricultural areas.
authors.affiliation: Chrono-Environnement UMR 6249 CNRS, Franche-Comté University, Besançon, France.
authors.forename: Steffi
authors.initials: S
authors.lastname: Rocchi
authors.forename: Etienne
authors.initials: E
authors.lastname: Daguindau
authors.forename: Frédéric
authors.initials: F
authors.lastname: Grenouillet
authors.forename: Eric
authors.initials: E
authors.lastname: Deconinck
authors.forename: Anne-Pauline
authors.initials: AP
authors.lastname: Bellanger
authors.forename: Dea
authors.initials: D
authors.lastname: Garcia-Hermoso
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bretagne
authors.forename: Gabriel
authors.initials: G
authors.lastname: Reboux
authors.forename: Laurence
authors.initials: L
authors.lastname: Millon
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D001228:Aspergillosis / Q000188:drug therapy / Q000382:microbiology*; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D001393:Azoles / Q000494:pharmacology*; D026141:Drug Resistance, Multiple, Fungal / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics; D005659:Fungicides, Industrial / Q000494:pharmacology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000382:microbiology*; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D066027:Transplant Recipients
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D005656:Fungal Proteins; D005659:Fungicides, Industrial