title: Akt-ivation of RNA splicing.
abstract: Cells must tightly control alternative splicing of RNA to maintain homeostasis; in this issue of Molecular Cell, Sanidas et al. (2014) provide new insights into the regulation of RNA splicing by Akt isoforms through phosphorylation of histone modification machinery.
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Gina
authors.initials: G
authors.lastname: Lee
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: john_blenis@hms.harvard.edu.
authors.forename: John
authors.initials: J
authors.lastname: Blenis
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D016601:RNA-Binding Proteins; D014157:Transcription Factors
chemical_list: C510636:Iws1 protein, human; D011506:Proteins; D016601:RNA-Binding Proteins; D014157:Transcription Factors; C494918:AKT1 protein, human; C491754:AKT3 protein, human; D051057:Proto-Oncogene Proteins c-akt