title: Adipokines, vascular wall, and cardiovascular disease: a focused overview of the role of adipokines in the pathophysiology of cardiovascular disease.
abstract: Epidemiological evidence has shown that abdominal obesity is closely associated with the development of cardiovascular (CV) disease, suggesting that it might be considered as an independent CV risk factor. However, the pathophysiological mechanisms responsible for the association between these 2 clinical entities remain largely unknown. Adipocytes are considered able to produce and secrete chemical mediators known as "adipokines" that may exert several biological actions, including those on heart and vessels. Of interest, a different adipokine profile can be observed in the plasma of patients with obesity or metabolic syndrome compared with healthy controls. We consider the main adipokines, focusing on their effects on the vascular wall and analyzing their role in CV pathophysiology.
authors.affiliation: Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples, Naples, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Maresca
authors.affiliation: Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples, Naples, Italy.
authors.forename: Vito
authors.initials: V
authors.lastname: Di Palma
authors.affiliation: Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples, Naples, Italy.
authors.forename: Michele
authors.initials: M
authors.lastname: Bevilacqua
authors.affiliation: Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples, Naples, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Uccello
authors.affiliation: Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples, Naples, Italy.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Taglialatela
authors.affiliation: Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples, Naples, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giaquinto
authors.affiliation: Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples, Naples, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Esposito
authors.affiliation: Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples, Naples, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Trimarco
authors.affiliation: Department of Advanced Biomedical Sciences, Division of Cardiology, University of Naples, Naples, Italy pcirillo@unina.it.
authors.forename: Plinio
authors.initials: P
authors.lastname: Cirillo
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D054392:Adipokines / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001808:Blood Vessels / Q000378:metabolism* / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology / Q000378:metabolism; D009765:Obesity / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D012307:Risk Factors; D015398:Signal Transduction
chemical_list: D054392:Adipokines; D015415:Biomarkers; D018836:Inflammation Mediators
keywords: acute coronary syndrome; adipokines; atherosclerosis; cardiovascular disease; inflammation; obesity; vascular wall