title: Brain Network Activation (BNA) reveals scopolamine-induced impairment of visual working memory.
abstract: The overarching goal of this event-related potential (ERP) study was to examine the effects of scopolamine on the dynamics of brain network activation using a novel ERP network analysis method known as Brain Network Activation (BNA). BNA was used for extracting group-common stimulus-activated network patterns elicited to matching probe stimuli in the context of a delayed matching-to-sample task following placebo and scopolamine treatments administered to healthy participants. The BNA extracted networks revealed the existence of two pathophysiological mechanisms following scopolamine, disconnection, and compensation. Specifically, weaker frontal theta and parietal alpha coupling was accompanied with enhanced fronto-centro-parietal theta activation relative to placebo. In addition, using the characteristic BNA network of each treatment as well as corresponding literature-guided selective subnetworks as combined biomarkers managed to differentiate between individual responses to each of the treatments. Behavioral effects associated with scopolamine included delayed response time and impaired response accuracy. These results indicate that the BNA method is sensitive to the effects of scopolamine on working memory and that it may potentially enable diagnosis and treatment assessment of dysfunctions associated with cholinergic deficiency.
authors.affiliation: ElMindA Ltd, Haminhara 16 St, Herzliya, Israel, 46586, amit@elminda.com.
authors.forename: Amit
authors.initials: A
authors.lastname: Reches
authors.forename: Naama
authors.initials: N
authors.lastname: Levy-Cooperman
authors.forename: Ilan
authors.initials: I
authors.lastname: Laufer
authors.forename: Revital
authors.initials: R
authors.lastname: Shani-Hershkovitch
authors.forename: Keren
authors.initials: K
authors.lastname: Ziv
authors.forename: Dani
authors.initials: D
authors.lastname: Kerem
authors.forename: Noga
authors.initials: N
authors.lastname: Gal
authors.forename: Yaki
authors.initials: Y
authors.lastname: Stern
authors.forename: Guy
authors.initials: G
authors.lastname: Cukierman
authors.forename: Myroslava K
authors.initials: MK
authors.lastname: Romach
authors.forename: Edward M
authors.initials: EM
authors.lastname: Sellers
authors.forename: Amir B
authors.initials: AB
authors.lastname: Geva
mesh_terms: D000293:Adolescent; D000328:Adult; D000513:Alpha Rhythm; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D008875:Middle Aged; D012601:Scopolamine / Q000494:pharmacology*; D013826:Theta Rhythm; D014796:Visual Perception
chemical_list: D012601:Scopolamine