title: Setting individualized positive end-expiratory pressure level with a positive end-expiratory pressure decrement trial after a recruitment maneuver improves oxygenation and lung mechanics during one-lung ventilation.
abstract: BACKGROUND
  We investigated whether individualized positive end-expiratory pressure (PEEP) improves oxygenation, ventilation, and lung mechanics during one-lung ventilation compared with standardized PEEP.
  
  
  METHODS
  Thirty patients undergoing thoracic surgery were randomly allocated to the study or control group. Both groups received an alveolar recruitment maneuver at the beginning and end of one-lung ventilation. After the alveolar recruitment maneuver, the control group had their lungs ventilated with a 5 cm·H2O PEEP, while the study group had their lungs ventilated with an individualized PEEP level determined by a PEEP decrement trial. Arterial blood samples, lung mechanics, and volumetric capnography were recorded at multiple timepoints throughout the procedure.
  
  
  RESULTS
  The individualized PEEP values in study group were higher than the standardized PEEP values (10 ± 2 vs 5 cm·H2O; P < 0.001). In both groups, arterial oxygenation decreased when bilateral-lung ventilation was switched to one-lung ventilation and increased after the alveolar recruitment maneuver. During one-lung ventilation, oxygenation was maintained in the study group but decreased in the control group. After one-lung ventilation, arterial oxygenation was significantly higher in the study group (306 vs 231 mm·Hg, P = 0.007). Static compliance decreased in both groups when bilateral-lung ventilation was switched to one-lung ventilation. Static compliance increased significantly only in the study group (P < 0.001) after the alveolar recruitment maneuver and optimal PEEP adjustment. The alveolar recruitment maneuver did not decrease cardiac index in any patient.
  
  
  CONCLUSIONS
  During one-lung ventilation, the improvements in oxygenation and lung mechanics after an alveolar recruitment maneuver were better preserved by ventilation by using individualized PEEP with a PEEP decrement trial than with a standardized 5 cm·H2O of PEEP.
authors.affiliation: From the *Anesthesiology and Critical Care Department, Hospital Clinico Universitario of Valencia, Valencia, Spain; and †Department of Anesthesiology, Hospital Privado de Comunidad, Mar de Plata, Argentina.
authors.forename: Carlos
authors.initials: C
authors.lastname: Ferrando
authors.forename: Ana
authors.initials: A
authors.lastname: Mugarra
authors.forename: Andrea
authors.initials: A
authors.lastname: Gutierrez
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Carbonell
authors.forename: Marisa
authors.initials: M
authors.lastname: García
authors.forename: Marina
authors.initials: M
authors.lastname: Soro
authors.forename: Gerardo
authors.initials: G
authors.lastname: Tusman
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Belda
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008170:Lung Compliance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D061810:One-Lung Ventilation / Q000379:methods*; D011175:Positive-Pressure Respiration / Q000379:methods*; D015656:Respiratory Mechanics / Q000502:physiology*