title: Roles of bone-marrow-derived cells and inflammatory cytokines in neointimal hyperplasia after vascular injury.
abstract: Bone-marrow-derived cells can generate vascular progenitor cells that contribute to pathological remodeling in models of restenosis after percutaneous coronary intervention (PCI). We created models of vascular injury in mice with bone marrow transplants (BMT) to determine relationships between bone-marrow-derived cells and subsequent biological factors. Mesenchymal stromal cells (MSCs) seemed to inhibit the inflammatory reaction and help stabilize injured vascular regions through mobilizing more endogenous bone-marrow-derived (EBMD) cells to the peripheral circulation. Granulocyte-colony stimulating factor (G-CSF) mobilized more EBMD cells to the peripheral circulation, and they accumulated on the injured side of the vascular lumen. The inflammatory cytokines, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6 mobilized EBMD cells that play an important role in the process of neointimal hyperplasia after vascular injury. These factors might comprise a mechanism that alters the transdifferentiation or paracrine capabilities of EBMD cells and are potential targets of treatment for patients with cardiovascular diseases.
authors.affiliation: Department of Medicine, Division of Cardiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Makoto
authors.identifier: 0000-0003-1250-5471
authors.initials: M
authors.lastname: Shoji
authors.affiliation: Department of Medicine, Division of Cardiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Koba
authors.affiliation: Department of Medicine, Division of Cardiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan.
authors.forename: Youichi
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism*; D005263:Femoral Artery / Q000293:injuries*; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism*; D059630:Mesenchymal Stem Cells; D051379:Mice; D033581:Stem Cell Transplantation; D017539:Tunica Intima / Q000378:metabolism*; D057772:Vascular System Injuries
chemical_list: D016179:Granulocyte Colony-Stimulating Factor