title: A functional polyester carrying free hydroxyl groups promotes the mineralization of osteoblast and human mesenchymal stem cell extracellular matrix.
abstract: Functional groups can control biointerfaces and provide a simple way to make therapeutic materials. We recently reported the design and synthesis of poly(sebacoyl diglyceride) (PSeD) carrying a free hydroxyl group in its repeating unit. This paper examines the use of this polymer to promote biomineralization for application in bone tissue engineering. PSeD promoted more mineralization of extracellular matrix secreted by human mesenchymal stem cells and rat osteoblasts than poly(lactic-co-glycolic acid) (PLGA), which is currently widely used in bone tissue engineering. PSeD showed in vitro osteocompatibility and in vivo biocompatibility that matched or surpassed that of PLGA, as well as supported the attachment, proliferation and differentiation of rat osteoblasts and human mesenchymal stem cells. This demonstrates the potential of PSeD for use in bone regeneration.
authors.affiliation: Department of Ophthalmology, Shanghai Ninth Peoples' Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, People's Republic of China; Departments of Bioengineering, Chemical Engineering, Surgery, and the McGowan Institute, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA.
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Bi
authors.affiliation: Departments of Bioengineering, Chemical Engineering, Surgery, and the McGowan Institute, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, 2999 North Renmin Road, Shanghai 201620, People's Republic of China.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: You
authors.affiliation: Departments of Bioengineering, Chemical Engineering, Surgery, and the McGowan Institute, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA.
authors.forename: Jin
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Ophthalmology, Shanghai Ninth Peoples' Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Rd, Shanghai 200011, People's Republic of China. Electronic address: Fanxq@sh163.net.
authors.forename: Xianqun
authors.initials: X
authors.lastname: Fan
authors.affiliation: Departments of Bioengineering, Chemical Engineering, Surgery, and the McGowan Institute, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA. Electronic address: yaw20@pitt.edu.
authors.forename: Yadong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001672:Biocompatible Materials; D002113:Calcification, Physiologic; D049109:Cell Proliferation; D002478:Cells, Cultured; D005109:Extracellular Matrix / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism; D011091:Polyesters
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters
keywords: Bone regeneration; Functional polymer; Hydroxyl group; Mineralization; Osteogenesis