title: Some in vitro/in vivo chemically-induced experimental models of liver oxidative stress in rats.
abstract: Oxidative stress is critically involved in a variety of diseases. Reactive oxygen species (ROS) are highly toxic molecules that are generated during the body's metabolic reactions and can react with and damage some cellular molecules such as lipids, proteins, or DNA. Liver is an important target of the oxidative stress because of its exposure to various prooxidant toxic compounds as well as of its metabolic function and ability to transform some xenobiotics to reactive toxic metabolites (as ROS). To investigate the processes of liver injuries and especially liver oxidative damages there are many experimental models, some of which we discuss further.
authors.affiliation: Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University 2 Dunav Street, 1000 Sofia, Bulgaria.
authors.forename: Rumyana
authors.identifier: 0000-0003-4860-9053
authors.initials: R
authors.lastname: Simeonova
authors.affiliation: Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University 2 Dunav Street, 1000 Sofia, Bulgaria.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kondeva-Burdina
authors.affiliation: Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University 2 Dunav Street, 1000 Sofia, Bulgaria.
authors.forename: Vessela
authors.initials: V
authors.lastname: Vitcheva
authors.affiliation: Laboratory of Drug Metabolism and Drug Toxicity, Department of Pharmacology, Pharmacotherapy and Toxicology, Faculty of Pharmacy, Medical University 2 Dunav Street, 1000 Sofia, Bulgaria.
authors.forename: Mitka
authors.initials: M
authors.lastname: Mitcheva
mesh_terms: D000818:Animals; D002460:Cell Line; D056486:Chemical and Drug Induced Liver Injury; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008954:Models, Biological; D018384:Oxidative Stress; D051381:Rats