title: Novel therapeutic approach for pulmonary emphysema using gelatin microspheres releasing basic fibroblast growth factor in a canine model.
abstract: OBJECTIVE
  The prognosis of patients with emphysema is poor as there is no truly effective treatment. Our previous study showed that the alveolar space was smaller and the microvessel density was higher in a canine emphysema model after the intrapulmonary arterial administration of gelatin microspheres slowly releasing basic fibroblast growth factor (bFGF-GMS). In the present study, we evaluated the functional effect of injecting bFGF-GMS via the pulmonary artery in this canine pulmonary emphysema model.
  
  
  METHODS
  Using the porcine pancreatic elastase (PPE)-induced total emphysema model, we approximated the value of lung compliance with a Power Lab System, and performed blood gas analysis in a control group, a total emphysema group, and a bFGF group in which bFGF-GMS were injected toward the whole pulmonary artery via the femoral vein. Each group comprised five dogs.
  
  
  RESULTS
  Lung compliance was higher in the total emphysema group than in the control group (p = 0.031), and the bFGF group showed no significant improvement of lung compliance vs. the total emphysema group (p = 0.112). PaO2 (partial pressure of oxygen in arterial blood) was improved by administering bFGF-GMS in the total emphysema model (p = 0.027).
  
  
  CONCLUSIONS
  In the canine total emphysema model, blood gas parameters were improved by the whole pulmonary arterial administration of bFGF-GMS. This method has the potential to be an effective novel therapy for pulmonary emphysema.
authors.affiliation: Department of General Thoracic, Breast, and Endocrinological Surgery, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Chang
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Yokomise
authors.forename: Natsumi
authors.initials: N
authors.lastname: Matsuura
authors.forename: Masashi
authors.initials: M
authors.lastname: Gotoh
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D004285:Dogs; D004337:Drug Carriers; D016222:Fibroblast Growth Factor 2 / Q000008:administration & dosage* / Q000627:therapeutic use*; D005780:Gelatin; D006801:Humans; D007269:Injections, Intra-Arterial; D008170:Lung Compliance; D008863:Microspheres; D010196:Pancreatic Elastase; D011651:Pulmonary Artery; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D013552:Swine
chemical_list: D004337:Drug Carriers; D016222:Fibroblast Growth Factor 2; D005780:Gelatin; D010196:Pancreatic Elastase