title: Combining corticosteroids and acyclovir in the management of varicella pneumonia: a prospective study.
abstract: BACKGROUND
  Studies found in the literature which describe the treatment of varicella pneumonia with a combination of acyclovir and corticosteroids tend to be retrospective in nature and limited with regard to the data supplied.
  
  
  METHODS
  This prospective study was performed at King Abdul Aziz Specialist Hospital in Taif, Saudi Arabia. The study covered adult patients admitted with a diagnosis of varicella pneumonia over a period of 10 years (January 2003 to December 2012). All patients were treated uniformly according to the predefined protocol with acyclovir and corticosteroids. The clinical characteristics, laboratory investigations, hospital course, any complications and the treatment outcomes were studied.
  
  
  RESULTS
  A total of 32 patients (25 males, mean age 43.5 ±14.5 years) were enrolled into this study; 3 patients (2 patients aged <12 years, 1 patient with advanced cardiac failure) were excluded. Of these 32 patients, 18 (58%) were current smokers, 16 patients (50%) were admitted to the intensive care unit and of these, 14 (87.5%) required mechanical ventilation. The mean duration of intensive care unit stay was 5.59 ±5.37 days. All patients were treated with intravenous acyclovir, corticosteroids and antibiotics were added when indicated. 31 patients improved and were discharged home. There was one death (a 32 year-old female with underlying systemic lupus erythematosus).
  
  
  CONCLUSIONS
  Patients with varicella pneumonia are at high risk of respiratory failure. Early implementation of supportive therapy seems to positively influence the recovery rate and outcome. Our study supports treatment using a combination of acyclovir and corticosteroids.
authors.affiliation: King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia.
authors.forename: Shaikh Khurshid
authors.initials: SK
authors.lastname: Anwar
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Masoodi
authors.forename: Abdulaziz
authors.initials: A
authors.lastname: Alfaifi
authors.forename: Shabnum
authors.initials: S
authors.lastname: Hussain
authors.forename: Irshad A
authors.initials: IA
authors.lastname: Sirwal
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use*; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002644:Chickenpox / Q000150:complications / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000305:Adrenal Cortex Hormones; D000212:Acyclovir