title: Targeting the inflammatory pathway as a therapeutic tool for major depression.
abstract: In the last decades convergent findings from several lines of evidence has revealed a robust association between major depressive disorder (MDD) and inflammatory pathways. Despite this, the translation of these findings into new and better treatments for MDD has not occurred. The objective of this study is to comprehensively review what is already known with reasonable certainty on inflammatory pathways in MDD, to clarify some points that have been insufficiently studied and to discuss the implications of these findings for future studies targeting inflammatory pathways as a therapeutic tool for individuals with MDD.
authors.affiliation: Interdisciplinary Laboratory of Clinical Neuroscience (LINC), Federal University of São Paulo, São Paulo, Brazil.
authors.forename: Cristiano
authors.initials: C
authors.lastname: Noto
authors.forename: Lucas B
authors.initials: LB
authors.lastname: Rizzo
authors.forename: Rodrigo B
authors.initials: RB
authors.lastname: Mansur
authors.forename: Roger S
authors.initials: RS
authors.lastname: McIntyre
authors.forename: Michael
authors.initials: M
authors.lastname: Maes
authors.forename: Elisa
authors.initials: E
authors.lastname: Brietzke
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000975:Antioxidants / Q000494:pharmacology; D003865:Major Depressive Disorder / Q000150:complications* / Q000276:immunology / Q000628:therapy; D006801:Humans; D007249:Inflammation / Q000150:complications* / Q000276:immunology / Q000628:therapy
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants