title: Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression.
abstract: Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a zinc-dependent type-I transmembrane metalloproteinase involved in pericellular proteolysis, migration and invasion. Numerous substrates and binding partners have been identified for MT1-MMP, and its role in collagenolysis appears crucial for tumor invasion. However, development of MT1-MMP inhibitors must consider the substantial functions of MT1-MMP in normal physiology and disease prevention. The present review examines the plethora of MT1-MMP activities, how these activities relate to cancer initiation and progression, and how they can be monitored in real time. Examination of MT1-MMP activities and cell surface behaviors can set the stage for the development of unique, selective MT1-MMP inhibitors.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma, 1110 North Stonewall Avenue, Oklahoma City, OK 73117, USA. mstawikowski@tpims.org.
authors.forename: Sonia
authors.initials: S
authors.lastname: Pahwa
authors.affiliation: Departments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, USA. mstawikowski@tpims.org.
authors.forename: Maciej J
authors.initials: MJ
authors.lastname: Stawikowski
authors.affiliation: Departments of Chemistry and Biology, Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL 34987, USA. gfields@tpims.org.
authors.forename: Gregg B
authors.initials: GB
authors.lastname: Fields