title: Meta-analysis of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and colorectal cancer risk.
abstract: A number of studies have explored the association of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and risk of colorectal cancer; however, the results are inconsistent. We performed this meta-analysis to clarify this issue using all the available evidence. Relevant studies were retrieved by searching PubMed. Eleven case-control studies were included in the meta-analysis, representing 2909 cases and 4903 controls. The pooled results based on all included studies showed a decreased colorectal cancer risk in the analysis of the GA genotype vs. the GG genotype (OR = 0.81, 95%CI = 0.68-0.98, p = 0.03) and in the dominant genetic model analysis (OR = 0.81, 95%CI = 0.67-0.98, p = 0.03). However, there was no statistical difference in the AA vs. GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17). Cumulative meta-analysis based on publication time confirmed these findings. Patients with colorectal cancer had a higher frequency of the GG genotype (OR = 1.10, 95% CI = 1.02-1.20, p = 0.02) and a lower frequency of the GA genotype (OR = 0.89, 95%CI = 0.81-0.98, p = 0.02) comparing with control population. Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.
authors.affiliation: School of Public Health, Central South University, Changsha, China ; Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Kui-Jie
authors.initials: KJ
authors.lastname: Liu
authors.affiliation: Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: Zhen-Dong
authors.initials: ZD
authors.lastname: Lei
authors.affiliation: Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.
authors.forename: San-Lin
authors.initials: SL
authors.lastname: Lei
authors.affiliation: School of Public Health, Central South University, Changsha, China.
authors.forename: Yong-Quan
authors.initials: YQ
authors.lastname: Tian
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial