title: A new xanthone from the pericarp of Garcinia mangostana.
abstract: A new prenylxanthone, garcimangostanol (1), was isolated from the EtOAc-soluble partition of the ethanol extract of the pericarp of Garcinia mangostana L., along with three known compounds, namely 8-deoxygartanin (2), 1-isomangostin (3), and garcinone C (4). The structure of compound 1 was elucidated on the basis of its 1D, 2D NMR and MS data. Compounds 1-4 exhibited either significant o r moderate cytotoxicity against MCF-7, A549, Hep-G2 and CNEhuman cancer cell lines in vitro with IC50 values from 4.0 +/- 0.3 to 23.6+/- 1.5 microM by MTT colorimetric assay.
authors.affiliation: Guangdong Open Access Laboratory ofAgri-food Processing, Sericulture and Agri-food Research Institute, Guangdong Academy of Agicultural Sciences, Guangzhou 510610, P.R. China fumanqin84@126.com
authors.forename: Manqin
authors.initials: M
authors.lastname: Fu
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, P.R. China.
authors.forename: Samuel X
authors.initials: SX
authors.lastname: Qiu
authors.affiliation: Guangdong Open Access Laboratory ofAgri-food Processing, Sericulture and Agri-food Research Institute, Guangdong Academy of Agicultural Sciences, Guangzhou 510610, P.R. China
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Guangdong Open Access Laboratory ofAgri-food Processing, Sericulture and Agri-food Research Institute, Guangdong Academy of Agicultural Sciences, Guangzhou 510610, P.R. China
authors.forename: Jijun
authors.initials: J
authors.lastname: Wu
authors.affiliation: Guangdong Open Access Laboratory ofAgri-food Processing, Sericulture and Agri-food Research Institute, Guangdong Academy of Agicultural Sciences, Guangzhou 510610, P.R. China
authors.forename: Yulong
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Guangdong Open Access Laboratory ofAgri-food Processing, Sericulture and Agri-food Research Institute, Guangdong Academy of Agicultural Sciences, Guangzhou 510610, P.R. China
authors.forename: Yuanshan
authors.initials: Y
authors.lastname: Yu
authors.affiliation: Guangdong Open Access Laboratory ofAgri-food Processing, Sericulture and Agri-food Research Institute, Guangdong Academy of Agicultural Sciences, Guangzhou 510610, P.R. China
authors.forename: Gengsheng
authors.initials: G
authors.lastname: Xiao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D029762:Garcinia mangostana / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones; C587188:garcimangostanol