title: Escherichia coli bacteraemia in adults: age-related differences in clinical and bacteriological characteristics, and outcome.
abstract: To explore the specificities of Escherichia coli bacteraemia in the elderly, the demographic, clinical and bacteriological characteristics and in-hospital mortality rate of 'young' (18-64 years, n = 395), 'old' (65-79 years, n = 372) and 'very old' (⩾80 years, n = 284) adult patients of the multicentre COLIBAFI cohort study were compared. Clinical and bacteriological risk factors for death were jointly identified by logistic regression and multivariate analysis within each group. 'Young' and 'old' patients had more comorbidities than 'very old' patients (comorbidity score: 1·5 ± 1·3 and 1·6 ± 1·2 vs. 1·2 ± 1·2, respectively; P < 0·001), and were more frequently nosocomially infected (22·3% and 23·8% vs. 8·8%, respectively; P < 0·001). 'Old' patients had the poorest prognosis (death rate: 16·4% vs.10·4% for 'young' and 12·0% for 'very old' patients, respectively; P = 0·039). Risk factors for death were age group-specific, suggesting a host-pathogen relationship evolving with age.
authors.affiliation: Pôle de Gérontologie Clinique, CHU Hôpitaux de Bordeaux,F-33000 Bordeaux,France.
authors.forename: C
authors.initials: C
authors.lastname: Roubaud Baudron
authors.affiliation: IAME, UMR 1137, INSERM, F-75018 Paris, France;Université Paris Diderot,Sorbonne Paris Cité, F-75018 Paris,France.
authors.forename: X
authors.initials: X
authors.lastname: Panhard
authors.affiliation: IAME, UMR 1137, INSERM, F-75018 Paris, France;Université Paris Diderot,Sorbonne Paris Cité, F-75018 Paris,France.
authors.forename: O
authors.initials: O
authors.lastname: Clermont
authors.affiliation: IAME, UMR 1137, INSERM, F-75018 Paris, France;Université Paris Diderot,Sorbonne Paris Cité, F-75018 Paris,France.
authors.forename: F
authors.initials: F
authors.lastname: Mentré
authors.affiliation: IAME, UMR 1137, INSERM, F-75018 Paris, France;Université Paris Diderot,Sorbonne Paris Cité, F-75018 Paris,France.
authors.forename: B
authors.initials: B
authors.lastname: Fantin
authors.affiliation: IAME, UMR 1137, INSERM, F-75018 Paris, France;Université Paris Diderot,Sorbonne Paris Cité, F-75018 Paris,France.
authors.forename: E
authors.initials: E
authors.lastname: Denamur
authors.affiliation: IAME, UMR 1137, INSERM, F-75018 Paris, France;Université Paris Diderot,Sorbonne Paris Cité, F-75018 Paris,France.
authors.forename: A
authors.initials: A
authors.lastname: Lefort
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D016470:Bacteremia / Q000382:microbiology* / Q000401:mortality*; D004927:Escherichia coli Infections / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D016896:Treatment Outcome