title: Factors influencing decisions about surgical treatment of cervical precancerous lesions.
abstract: Cervical precancerous lesions represented by cervical intraepithelial neoplasia (CIN) and cervical glandular intraepithelial neoplasia may progress to invasive cancer. The principle treatment of CIN is eradication of the transformation zone. However, all eradication methods are associated with some adverse events, particularly with perinatal consequences. It is therefore necessary to identify which women have CIN that has a low risk of transformation into invasive cancer. The presence of modifying factors can help to stratify CIN lesions according to their malignant potential. The evaluation of HPV genotype in particular holds great promise for defining patients at greater risk. Tailoring treatment to the individual patient is going to become a major consideration in the management of cervical precancerous lesions.
authors.affiliation: First Faculty of Medicine, Charles University in Prague and Hospital Na Bulovce in Prague, Budinova 2, 180 81, Prague 8, Czech Republic.
authors.forename: Borek
authors.initials: B
authors.lastname: Sehnal
authors.forename: David
authors.initials: D
authors.lastname: Cibula
authors.forename: Jiri
authors.initials: J
authors.lastname: Slama
mesh_terms: D000367:Age Factors; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic; D003127:Colposcopy; D003657:Decision Making; D005260:Female; D005838:Genotype; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics; D018579:Patient Selection; D011230:Precancerous Conditions / Q000473:pathology* / Q000601:surgery* / Q000821:virology; D017584:Reproductive History; D019233:Retreatment; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery* / Q000821:virology
chemical_list: D014408:Biomarkers, Tumor