title: Successful treatment of oral verrucous hyperplasia with photodynamic therapy combined with cryotherapy--report of 3 cases.
abstract: Our previous study showed successful treatment of a large oral verrucous hyperplasia (OVH) with topical 5-aminolevulinic acid-mediated photodynamic therapy combined with cryotherapy (ALA-PDT). In this case series, we extended this combined method for another three OVH lesions in three different patients. The clinical procedure was conducted as follows: the OVH lesions were irradiated with a 635-nm laser 1.5h after topical application of 20% ALA on the lesion for a total of 1000 s, which consisted of five 3-min and one 100-s irradiations separated by five 3-min rests. Cryogun cryotherapy was then performed on the lesion after ALA-PDT. The tumor was cleared after 1-6 treatments. No recurrence of the lesion was found after a follow-up period of 6-24 months. We suggest that our combined treatment protocol may be effective in treating OVH lesions.
authors.affiliation: School of Dentistry, College of Oral Medicine, Chung Shan Medical University, Taichung, Taiwan.
authors.forename: Yu-Chao
authors.initials: YC
authors.lastname: Chang
authors.affiliation: Department of Stomatology, Oral Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan. Electronic address: tao2008@csmu.edu.tw.
authors.forename: Chuan-Hang
authors.initials: CH
authors.lastname: Yu
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D018289:Carcinoma, Verrucous / Q000473:pathology* / Q000628:therapy*; D003131:Combined Modality Therapy; D017679:Cryotherapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000628:therapy*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
keywords: Cryotherapy; Oral verrucous hyperplasia; Photodynamic therapy