title: The pre-mRNA splicing reaction.
abstract: In eukaryotic organisms, nascent transcripts of protein-coding genes contain intronic sequences that are not present in mature mRNAs. Pre-mRNA splicing removes introns and joins exons to form mature mRNAs. It is catalyzed by a large RNP complex called the spliceosome. Sequences within the pre-mRNA determine intron recognition and excision. This process occurs with a high degree of accuracy to generate the functional transcriptome of a cell.
authors.affiliation: Department of Immunology and Molecular Genetics, Molecular Biology Institute, University of California, Los Angeles, CA, USA.
authors.forename: Somsakul Pop
authors.initials: SP
authors.lastname: Wongpalee
authors.forename: Shalini
authors.initials: S
authors.lastname: Sharma
mesh_terms: D001483:Base Sequence; D005091:Exons / Q000235:genetics; D020869:Gene Expression Profiling; D006801:Humans; D007438:Introns / Q000235:genetics; D008967:Molecular Biology / Q000379:methods*; D012322:RNA Precursors / Q000235:genetics*; D012326:RNA Splicing; D017381:Spliceosomes / Q000235:genetics*
chemical_list: D012322:RNA Precursors