title: The role of inab in axon morphology of an identified zebrafish motoneuron.
abstract: The ability of an animal to move and to interact with its environment requires that motoneurons correctly innervate specific muscles. Although many genes that regulate motoneuron development have been identified, our understanding of motor axon branching remains incomplete. We used transcriptional expression profiling to identify potential candidate genes involved in development of zebrafish identified motoneurons. Here we focus on inab, an intermediate filament encoding gene dynamically expressed in a subset of motoneurons as well as in an identified interneuron. We show that inab is necessary for proper axon morphology of a specific motoneuron subtype.
authors.affiliation: Institute of Neuroscience, Eugene, Oregon, United States of America.
authors.forename: Liesl
authors.initials: L
authors.lastname: Van Ryswyk
authors.affiliation: Institute of Neuroscience, Eugene, Oregon, United States of America.
authors.forename: Levi
authors.initials: L
authors.lastname: Simonson
authors.affiliation: Institute of Neuroscience, Eugene, Oregon, United States of America.
authors.forename: Judith S
authors.initials: JS
authors.lastname: Eisen
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D002454:Cell Differentiation; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D049452:Green Fluorescent Proteins / Q000378:metabolism; D017404:In Situ Hybridization, Fluorescence; D007395:Interneurons / Q000166:cytology; D009046:Motor Neurons / Q000166:cytology*; D016900:Neurofilament Proteins / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D013116:Spinal Cord / Q000196:embryology* / Q000473:pathology; D014158:Transcription, Genetic; D015027:Zebrafish; D029961:Zebrafish Proteins / Q000502:physiology*
chemical_list: C000594259:Inab protein, zebrafish; D016900:Neurofilament Proteins; D029961:Zebrafish Proteins; D049452:Green Fluorescent Proteins