title: Prognostic factors in women with synchronous endometrial and ovarian cancers.
abstract: OBJECTIVE
  The purpose of this study was to determine the prognostic factors in women with synchronous endometrial and ovarian cancers.
  
  
  METHODS
  Medical records of 3240 patients with endometrial cancer who had undergone primary surgery were collected from 7 institutions and were retrospectively reviewed. The progression-free survival (PFS) and overall survival (OS) curves and rates were calculated using the Kaplan-Meier method. Multivariate analysis to determine independent prognostic factors was performed using the Cox regression model.
  
  
  RESULTS
  The incidence of synchronous endometrial/ovarian cancer was 3.8% (123/3240 women). During the median follow-up period of 66 months, 33.3% and 26.1% of women developed recurrences and reported cancer-related deaths. The 5-year PFS and 5-year OS for all 123 women were 66.9% and 80.0%, respectively. In multivariate analysis, pretreatment CA-125 and tumor stage of the ovary showed prognostic significance about PFS (P = 0.043 and P = 0.027) and OS (P = 0.047 and P = 0.031), respectively.
  
  
  CONCLUSIONS
  Pretreatment CA-125 and tumor stage of the ovary were independent prognostic factors for recurrence and survival.
authors.affiliation: *Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University; †Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine; ‡Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul; §Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam; ∥Department of Obstetrics and Gynecology, Seoul St Mary's Hospital, Catholic University of Korea, Seoul; ¶Gynecologic Cancer Branch and Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang; and #Department of Obstetrics and Gynecology, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
authors.forename: Taejong
authors.initials: T
authors.lastname: Song
authors.forename: Seok Ju
authors.initials: SJ
authors.lastname: Seong
authors.forename: Duk-Soo
authors.initials: DS
authors.lastname: Bae
authors.forename: Jong-Hyeok
authors.initials: JH
authors.lastname: Kim
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Suh
authors.forename: Keun-Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Park
authors.forename: Taek Sang
authors.initials: TS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016889:Endometrial Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D010051:Ovarian Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D010053:Ovary / Q000473:pathology; D011379:Prognosis; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D055815:Young Adult