title: Coumarinoids from the fruits of Micromelum falcatum.
abstract: Four new compounds, microminutin B (1), microminutin C (2), micromarinate (3), and secomicromelin (4) as well as 17 known compounds were isolated from the fruits of Micromelum falcatum. All compounds were evaluated for antifungal activity against Pythium insidiosum using disc diffusion assay. P. insidiosum is a fungus-like microorganism for which antifungal agents now available are not effective. The results show that four compounds including secomicromelin (4), 7-methoxy-8-(4'-methyl-3'-furanyl)coumarin (10), micromarin B (17), and isomicromelin (19) could inhibit the mycelia growth of P. insidiosum.
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Jittra
authors.initials: J
authors.lastname: Suthiwong
authors.affiliation: Department of Science and Technology, Faculty of Liberal Arts and Science, Roi-Et Rajabhat University, Selapoom, Roi-Et 45120, Thailand.
authors.forename: Uraiwan
authors.initials: U
authors.lastname: Sriphana
authors.affiliation: Department of Medical Technology, Faculty of Allied Health Science, Naresuan University, Phitsanulok 65000, Thailand.
authors.forename: Yordhathai
authors.initials: Y
authors.lastname: Thongsri
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Pawantree
authors.initials: P
authors.lastname: Promsuwan
authors.affiliation: Department of Microbiology, Faculty of Associated Medical Sciences, Centre for Research and Development of Medical Diagnosis Laboratories, Khon Kaen University, Khon Kaen 40002, Thailand.
authors.forename: Chularut
authors.initials: C
authors.lastname: Prariyachatigul
authors.affiliation: Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: chayen@kku.ac.th.
authors.forename: Chavi
authors.initials: C
authors.lastname: Yenjai
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011775:Pythium / Q000187:drug effects* / Q000254:growth & development; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D003374:Coumarins; D010936:Plant Extracts; C030123:coumarin
keywords: Antifungal; Micromelum falcatum; Pythium insidiosum