title: Fetal alcohol syndrome and secondary schizophrenia: a unique neuropathologic study.
abstract: We report the unique neuropathologic study of an adult brain of a patient with fetal alcohol syndrome who developed the well-recognized complication of schizophrenia in adolescence. The major finding was asymmetric formation of the lateral temporal lobes, with marked enlargement of the right superior temporal gyrus, suggesting that alcohol is preferentially toxic to temporal lobe patterning during gestation. Critical maturational changes unique to adolescence can unmask psychotic symptomatology mediated by temporal lobe pathology that has been clinically dormant since birth. Elucidating the neuropathologic basis of the secondary psychiatric disorders in fetal alcohol syndrome can help provide insight into their putative developmental origins.
authors.affiliation: Department of Pathology, Sanford Health, Sioux Falls, SD, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Stoos
authors.affiliation: Department of Pathology, MaineGeneral Health, Augusta, MA, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Nelsen
authors.affiliation: Department of Pathology, Boston Children's Hospital and Harvard Medical School, MA, USA.
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Schissler
authors.affiliation: Department of Pathology, Boston Children's Hospital and Harvard Medical School, MA, USA.
authors.forename: Amy J
authors.initials: AJ
authors.lastname: Elliott
authors.affiliation: Department of Pathology, Boston Children's Hospital and Harvard Medical School, MA, USA Hannah.Kinney@Childrens.Harvard.edu.
authors.forename: Hannah C
authors.initials: HC
authors.lastname: Kinney
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000473:pathology*; D006801:Humans; D012559:Schizophrenia / Q000209:etiology / Q000473:pathology*
keywords: areal patterning; schizophrenia; superior temporal gyrus