title: Relationship of asymmetrical dimethylarginine, nitric oxide, and sustained attention during attack in patients with major depressive disorder.
abstract: We investigated the relationship of serum nitric oxide (NO) and asymmetrical dimethylarginine (ADMA) levels with cognitive functioning in patients with major depressive disorder (MDD). 41 MDD patients (Beck depression scale scores>16) and 44 controls were included in the study. Rey verbal learning and memory test, auditory consonant trigram test, digit span test, Wisconsin card sorting test, continuous performance task (TOVA), and Stroop test scores were found to be impaired in patients with major depressive disorder when compared to healthy controls. There was no significant difference between patient and control groups in terms of serum NO and ADMA. Serum NO levels were correlated with TOVA test error scores and Stroop test time scores, whereas serum ADMA levels were negatively correlated with TOVA test error scores. Metabolic detriments especially in relation to NO metabolism in frontal cortex and hypothalamus, psychomotor retardation, or loss of motivation may explain these deficits.
authors.affiliation: Department of Psychiatry, Çumra State Hospital, 42500 Konya, Turkey.
authors.forename: Serpil
authors.identifier: 0000-0002-8417-642X
authors.initials: S
authors.lastname: Canpolat
authors.affiliation: Department of Psychiatry, School of Medicine, Bezmialem Vakif University, 34093 Istanbul, Turkey.
authors.forename: Ismet
authors.identifier: 0000-0001-9816-3438
authors.initials: I
authors.lastname: Kırpınar
authors.affiliation: Department of Psychiatry, School of Medicine, Bezmialem Vakif University, 34093 Istanbul, Turkey.
authors.forename: Erdem
authors.identifier: 0000-0002-9661-8344
authors.initials: E
authors.lastname: Deveci
authors.affiliation: Department of Biochemistry, School of Medicine, Atatürk University, 25240 Erzurum, Turkey.
authors.forename: Hülya
authors.initials: H
authors.lastname: Aksoy
authors.affiliation: Department of Biochemistry, School of Medicine, Atatürk University, 25240 Erzurum, Turkey.
authors.forename: Zafer
authors.initials: Z
authors.lastname: Bayraktutan
authors.affiliation: Department of Psychiatry, Konya Training and Research Hospital, 42090 Konya, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Eren
authors.affiliation: Department of Neurology, School of Medicine, Atatürk University, 25240 Erzurum, Turkey.
authors.forename: Recep
authors.identifier: 0000-0002-7688-9825
authors.initials: R
authors.lastname: Demir
authors.affiliation: Department of Psychiatry, School of Medicine, Medeniyet University, 34722 Istanbul, Turkey.
authors.forename: Salih
authors.identifier: 0000-0001-5197-5682
authors.initials: S
authors.lastname: Selek
authors.affiliation: Department of Psychiatry, School of Medicine, Atatürk University, 25240 Erzurum, Turkey.
authors.forename: Nazan
authors.initials: N
authors.lastname: Aydın
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001288:Attention / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D003865:Major Depressive Disorder / Q000097:blood* / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009569:Nitric Oxide / Q000097:blood*; D011569:Psychiatric Status Rating Scales; D055815:Young Adult
chemical_list: D015415:Biomarkers; C487735:dimethylarginine; D009569:Nitric Oxide; D001120:Arginine