title: Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic.
abstract: This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus. This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections.
authors.affiliation: Laboratory of Molecular Biomedicine, Universiti Putra Malaysia, Selangor, Malaysia.
authors.forename: Samer Hasan
authors.initials: SH
authors.lastname: Hussein-Al-Ali
authors.affiliation: Laboratory of Vaccines and Immunotherapeutics, Institute of Bioscience, Universiti Putra Malaysia, Selangor, Malaysia ; Department of Environmental Health, Faculty of Public Health and Tropical Medicine, Jazan University, Jazan.
authors.forename: Mohamed Ezzat
authors.initials: ME
authors.lastname: El Zowalaty
authors.affiliation: Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, Universiti Putra Malaysia, Selangor, Malaysia.
authors.forename: Mohd Zobir
authors.initials: MZ
authors.lastname: Hussein
authors.affiliation: Laboratory of Molecular Biomedicine, Universiti Putra Malaysia, Selangor, Malaysia ; Department of Nutrition and Dietetics, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Selangor, Malaysia.
authors.forename: Maznah
authors.initials: M
authors.lastname: Ismail
authors.affiliation: Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA ; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Webster
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D048271:Chitosan / Q000737:chemistry*; D003692:Delayed-Action Preparations; D006801:Humans; D058185:Magnetite Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry* / Q000648:ultrastructure; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008954:Models, Biological; D015394:Molecular Structure; D053761:Nanocomposites / Q000008:administration & dosage / Q000737:chemistry / Q000648:ultrastructure; D050997:Nanomedicine; D017550:Spectroscopy, Fourier Transform Infrared; D013307:Streptomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D058185:Magnetite Nanoparticles; D048271:Chitosan; D013307:Streptomycin
keywords: antimicrobial activity; chitosan; magnetic nanoparticles; methicillin-resistant Staphylococcus aureus; nanoantibiotics; release; streptomycin