title: Synthesis, spectral characterization and antimicrobial studies of nano-sized oxovanadium(IV) complexes with Schiff bases derived from 5-(phenyl/substituted phenyl)-2-hydrazino-1,3,4-thiadiazole and indoline-2,3-dione.
abstract: A new class of oxovanadium(IV) complexes with Schiff bases derived by the condensation of 5-(phenyl/substituted phenyl)-2-hydrazino-1,3,4-thiadiazoles and indoline-2,3-dione have been prepared in ethanol in the presence of sodium acetate. Micro-analytical data, magnetic susceptibility, UV-Vis, IR, EPR and XRD spectral techniques were used to confirm the structures. Electronic absorption spectra of the complexes suggest a square-pyramidal geometry. The oxovanadium(IV) complexes have monoclinic crystal system and particle sizes were found to be in the range 18.0 nm to 24.0 nm (nano-size). In vitro antifungal activity of synthesized compounds was determined against fungi Aspergillus niger, Colletotrichum falcatum and Colletotrichum pallescence and in vitro antibacterial activity was determined by screening the compounds against Gram-negative (Escherichia coli and Salmonella typhi) and Gram-positive (Staphylococcus aureus and Bacillus subtilis) bacterial strains. The oxovanadium(IV) complexes have higher antimicrobial effect than free ligands.
authors.affiliation: Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273 009, India.
authors.forename: M K
authors.initials: MK
authors.lastname: Sahani
authors.affiliation: Department of Physics, DDU Gorakhpur University, Gorakhpur 273 009, India.
authors.forename: U
authors.initials: U
authors.lastname: Yadava
authors.affiliation: Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273 009, India.
authors.forename: O P
authors.initials: OP
authors.lastname: Pandey
authors.affiliation: Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273 009, India. Electronic address: sengupta@hotmail.co.uk.
authors.forename: S K
authors.initials: SK
authors.lastname: Sengupta
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D007211:Indoles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013830:Thiadiazoles / Q000737:chemistry*; D014638:Vanadates / Q000737:chemistry* / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D007211:Indoles; D012545:Schiff Bases; D013830:Thiadiazoles; C572590:indoline-2,3-dione; C058949:1,3,4-thiadiazole; C075743:oxovanadium IV; D014638:Vanadates
keywords: Antimicrobial; EPR; IR; Oxovanadium(IV); Schiff bases; XRD