title: A perspective from transport protein particle: vesicle tether and human diseases.
abstract: Vesicle-mediated transport of proteins is a highly regulated, multi-step process. When the vesicle is approaching its target membrane compartment, many factors are required to provide specificity and tethering between the incoming vesicle and the target membrane, before vesicle fusion can occur. Tethering factors, which include multisubunit complexes, coiled-coil proteins, with the help of small GTPases, provide the initial interaction between the vesicle and its target membrane. Of the multisubunit tethering factors, the transport protein particle (TRAPP) complexes function in a number of trafficking steps, including endoplasmic reticulum (ER)-to-Golgi transport, intra- and post-Golgi traffic and autophagosome formation. In this review, we summarize the updated progress in structure and function of TRAPP complexes as well as human diseases caused by genetic mutations in TRAPP.
authors.affiliation: School of Biomedical Sciences and Epithelial Cell Biology Research Centre, The Chinese University of Hong Kong, Hong Kong, China. b113318@cuhk.edu.hk.
authors.forename: Chunman
authors.initials: C
authors.lastname: Li
authors.forename: Sidney
authors.initials: S
authors.lastname: Yu
mesh_terms: D000818:Animals; D004721:Endoplasmic Reticulum / Q000473:pathology / Q000502:physiology; D006056:Golgi Apparatus / Q000473:pathology* / Q000502:physiology; D006801:Humans; D009154:Mutation; D021381:Protein Transport; D033921:Vesicular Transport Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D033921:Vesicular Transport Proteins