title: Screening for sleep apnoea in mild cognitive impairment: the utility of the multivariable apnoea prediction index.
abstract: Purpose. Mild cognitive impairment (MCI) is considered an "at risk" state for dementia and efforts are needed to target modifiable risk factors, of which Obstructive sleep apnoea (OSA) is one. This study aims to evaluate the predictive utility of the multivariate apnoea prediction index (MAPI), a patient self-report survey, to assess OSA in MCI. Methods. Thirty-seven participants with MCI and 37 age-matched controls completed the MAPI and underwent polysomnography (PSG). Correlations were used to compare the MAPI and PSG measures including oxygen desaturation index and apnoea-hypopnoea index (AHI). Receiver-operating characteristics (ROC) curve analyses were performed using various cut-off scores for apnoea severity. Results. In controls, there was a significant moderate correlation between higher MAPI scores and more severe apnoea (AHI: r = 0.47, P = 0.017). However, this relationship was not significant in the MCI sample. ROC curve analysis indicated much lower area under the curve (AUC) in the MCI sample compared to the controls across all AHI severity cut-off scores. Conclusions. In older people, the MAPI moderately correlates with AHI severity but only in those who are cognitively intact. Development of further screening tools is required in order to accurately screen for OSA in MCI.
authors.affiliation: Healthy Brain Ageing Clinic, Brain & Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia.
authors.forename: Georgina
authors.initials: G
authors.lastname: Wilson
authors.affiliation: Healthy Brain Ageing Clinic, Brain & Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Terpening
authors.affiliation: Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW 2050, Australia.
authors.forename: Keith
authors.initials: K
authors.lastname: Wong
authors.affiliation: Woolcock Institute of Medical Research, University of Sydney, Glebe, NSW 2050, Australia.
authors.forename: Ron
authors.initials: R
authors.lastname: Grunstein
authors.affiliation: Healthy Brain Ageing Clinic, Brain & Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia.
authors.forename: Louisa
authors.initials: L
authors.lastname: Norrie
authors.affiliation: Healthy Brain Ageing Clinic, Brain & Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia.
authors.forename: Simon J G
authors.initials: SJ
authors.lastname: Lewis
authors.affiliation: Healthy Brain Ageing Clinic, Brain & Mind Research Institute, University of Sydney, 94 Mallett Street, Camperdown, NSW 2050, Australia.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Naismith