title: Genomic profiling in triple-negative breast cancer.
abstract: Triple-negative breast cancer (TNBC) is defined by a lack of hormone receptor expression as well as lack of overexpression/amplification of HER2/neu. Patients with TNBC show a significantly worse prognosis compared to patients with other breast cancer subtypes. TNBC, however, is a heterogeneous entity both with regard to clinical/pathological characteristics and molecular biology. This review summarizes the current data on TNBC with a particular focus on mutational and gene expression profiling and the association between TNBC and breast cancer stem cells.
authors.affiliation: Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Schleswig-Holstein/Campus Lübeck, Germany.
authors.forename: Cornelia
authors.initials: C
authors.lastname: Liedtke
authors.affiliation: Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Münster, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Bernemann
authors.affiliation: Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Münster, Germany.
authors.forename: Ludwig
authors.initials: L
authors.lastname: Kiesel
authors.affiliation: Klinik für Gynäkologie und Geburtshilfe, Universitätsklinikum Schleswig-Holstein/Campus Lübeck, Germany.
authors.forename: Achim
authors.initials: A
authors.lastname: Rody
keywords: Heterogeneity; RNA profiling; Triple negative breast cancer, subtypes; Whole genome sequencing