title: Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.
abstract: Ependymomas are common childhood brain tumours that occur throughout the nervous system, but are most common in the paediatric hindbrain. Current standard therapy comprises surgery and radiation, but not cytotoxic chemotherapy as it does not further increase survival. Whole-genome and whole-exome sequencing of 47 hindbrain ependymomas reveals an extremely low mutation rate, and zero significant recurrent somatic single nucleotide variants. Although devoid of recurrent single nucleotide variants and focal copy number aberrations, poor-prognosis hindbrain ependymomas exhibit a CpG island methylator phenotype. Transcriptional silencing driven by CpG methylation converges exclusively on targets of the Polycomb repressive complex 2 which represses expression of differentiation genes through trimethylation of H3K27. CpG island methylator phenotype-positive hindbrain ependymomas are responsive to clinical drugs that target either DNA or H3K27 methylation both in vitro and in vivo. We conclude that epigenetic modifiers are the first rational therapeutic candidates for this deadly malignancy, which is epigenetically deregulated but genetically bland.
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada [4].
authors.forename: S C
authors.initials: SC
authors.lastname: Mack
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [3] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [4].
authors.forename: H
authors.initials: H
authors.lastname: Witt
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: R M
authors.initials: RM
authors.lastname: Piro
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Gu
authors.affiliation: Department of Molecular Genetics, Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Ontario M4N 1X8, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Zuyderduyn
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Genome Biology, European Molecular Biology, Laboratory Meyerhofstr. 1, Heidelberg 69117, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Stütz
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Gallo
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Garzia
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Zayne
authors.affiliation: Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: V
authors.initials: V
authors.lastname: Ramaswamy
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Jäger
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: D T W
authors.initials: DT
authors.lastname: Jones
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Sill
authors.affiliation: Department of Neurology, Harvard Medical School, Children's Hospital Boston, MIT, Boston, Massachusetts 02115, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Pugh
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Ryzhova
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Wani
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: D J H
authors.initials: DJ
authors.lastname: Shih
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Head
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Remke
authors.affiliation: 1] Ontario Cancer Institute, Princess Margaret Cancer Centre-University Health Network, Toronto, Ontario M5G 1L7, Canada [2] Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada.
authors.forename: S D
authors.initials: SD
authors.lastname: Bailey
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Genome Biology, European Molecular Biology, Laboratory Meyerhofstr. 1, Heidelberg 69117, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Zichner
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: C C
authors.initials: CC
authors.lastname: Faria
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Barszczyk
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Stark
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Seker-Cin
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Hutter
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Johann
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Bender
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Hovestadt
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Tzaridis
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: A M
authors.initials: AM
authors.lastname: Dubuc
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: P A
authors.initials: PA
authors.lastname: Northcott
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Peacock
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: K C
authors.initials: KC
authors.lastname: Bertrand
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Agnihotri
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: F M G
authors.initials: FM
authors.lastname: Cavalli
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: I
authors.initials: I
authors.lastname: Clarke
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: K
authors.initials: K
authors.lastname: Nethery-Brokx
authors.affiliation: Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Creasy
authors.affiliation: Cancer Epigenetics Discovery Performance Unit, GlaxoSmithKline Pharmaceuticals, Collegeville, Pennsylvania 19426, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Verma
authors.affiliation: Department of Oncogenomics, Academic Medical Center, Amsterdam 1105, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Koster
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: X
authors.initials: X
authors.lastname: Wu
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: Y
authors.initials: Y
authors.lastname: Yao
authors.affiliation: 1] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [3] CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Milde
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Sin-Chan
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Zuccaro
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Lau
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Pereira
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Castelo-Branco
authors.affiliation: 1] Centre for High-Throughput Biology, Department of Microbiology & Immunology, University of British Columbia, Vancouver, V6T 1Z4 British Columbia, Canada [2] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Hirst
authors.affiliation: 1] Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada [2] Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: Marra
authors.affiliation: Department of Pediatrics and National Capital Consortium, Uniformed Services University, Bethesda, Maryland 20814, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Roberts
authors.affiliation: Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA.
authors.forename: D
authors.initials: D
authors.lastname: Fults
authors.affiliation: Pediatric Neurosurgery, Catholic University Medical School, Gemelli Hospital, Rome 00168, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Massimi
authors.affiliation: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Cho
authors.affiliation: Department of Pediatrics, Virginia Commonwealth, Richmond, Virginia 23298-0646, USA.
authors.forename: T
authors.initials: T
authors.lastname: Van Meter
authors.affiliation: Department of Pathology, University of Warsaw, Children's Memorial Health Institute University of Warsaw, Warsaw 04-730, Poland.
authors.forename: W
authors.initials: W
authors.lastname: Grajkowska
authors.affiliation: Division of Anatomical Pathology, Department of Pathology and Molecular Medicine, McMaster University, Hamilton General Hospital, Hamilton, Ontario L8S 4K1, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Lach
authors.affiliation: 1] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: A E
authors.initials: AE
authors.lastname: Kulozik
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Department of Neuropathology Ruprecht-Karls-University Heidelberg, Institute of Pathology, Heidelberg 69120, Germany.
authors.forename: A
authors.initials: A
authors.lastname: von Deimling
authors.affiliation: 1] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [3] CCU Pediatric Oncology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Witt
authors.affiliation: Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada.
authors.forename: S W
authors.initials: SW
authors.lastname: Scherer
authors.affiliation: 1] University of Michigan Cell and Developmental Biology, Ann Arbor, Michigan 48109-2200, USA [2] Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
authors.forename: X
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Muraszko
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Kool
authors.affiliation: Department of Neurology, Harvard Medical School, Children's Hospital Boston, MIT, Boston, Massachusetts 02115, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Pomeroy
authors.affiliation: Department of Neurosurgery, University of California San Francisco, San Francisco, California 94143-0112, USA.
authors.forename: N
authors.initials: N
authors.lastname: Gupta
authors.affiliation: Departments of Neurology, Pediatrics, and Neurosurgery, University of California, San Francisco, The Helen Diller Family Cancer Research Building, San Francisco, California 94158, USA.
authors.forename: J
authors.initials: J
authors.lastname: Phillips
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Department of Neuro-oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Huang
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Department of Neuro-oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
authors.forename: U
authors.initials: U
authors.lastname: Tabori
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: C
authors.initials: C
authors.lastname: Hawkins
authors.affiliation: Department of Haematology and Oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Malkin
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: P N
authors.initials: PN
authors.lastname: Kongkham
authors.affiliation: Departments of Neurology, Pediatrics, and Neurosurgery, University of California, San Francisco, The Helen Diller Family Cancer Research Building, San Francisco, California 94158, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Weiss
authors.affiliation: Departments of Pediatrics and Human Genetics, McGill University and the McGill University Health Center Research Institute, Montreal, Quebec H3Z 2Z3, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Jabado
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: J T
authors.initials: JT
authors.lastname: Rutka
authors.affiliation: Department of Neuro-oncology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada.
authors.forename: E
authors.initials: E
authors.lastname: Bouffet
authors.affiliation: Genome Biology, European Molecular Biology, Laboratory Meyerhofstr. 1, Heidelberg 69117, Germany.
authors.forename: J O
authors.initials: JO
authors.lastname: Korbel
authors.affiliation: 1] Ontario Cancer Institute, Princess Margaret Cancer Centre-University Health Network, Toronto, Ontario M5G 1L7, Canada [2] Ontario Institute for Cancer Research, Toronto, Ontario M5G 1L7, Canada [3] Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1X8, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Lupien
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
authors.forename: K D
authors.initials: KD
authors.lastname: Aldape
authors.affiliation: Department of Molecular Genetics, Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Ontario M4N 1X8, Canada.
authors.forename: G D
authors.initials: GD
authors.lastname: Bader
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Eils
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Lichter
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada [4] Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: P B
authors.initials: PB
authors.lastname: Dirks
authors.affiliation: 1] Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany [2] Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg 69120, Germany [3] German Cancer Consortium (DKTK), Heidelberg 69120, Germany.
authors.forename: S M
authors.initials: SM
authors.lastname: Pfister
authors.affiliation: 1] German Cancer Consortium (DKTK), Heidelberg 69120, Germany [2] University of Michigan Cell and Developmental Biology, Ann Arbor, Michigan 48109-2200, USA [3] CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Korshunov
authors.affiliation: 1] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: M D
authors.initials: MD
authors.lastname: Taylor
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy / Q000235:genetics; D018899:CpG Islands / Q000235:genetics*; D019175:DNA Methylation / Q000187:drug effects; D053595:Embryonic Stem Cells / Q000378:metabolism; D004806:Ependymoma / Q000188:drug therapy / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D057890:Epigenomics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing / Q000187:drug effects; D006657:Histones / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007223:Infant; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D009154:Mutation / Q000235:genetics; D010641:Phenotype; D063151:Polycomb Repressive Complex 2 / Q000378:metabolism; D011379:Prognosis; D012249:Rhombencephalon / Q000473:pathology; D023041:Xenograft Model Antitumor Assays
chemical_list: D006657:Histones; D063151:Polycomb Repressive Complex 2