title: Organelle communication: signaling crossroads between homeostasis and disease.
abstract: Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are important for Ca2+ and lipid homeostasis, and serve as platforms for the control of many essential functions including metabolism, signaling, organelle integrity and execution of the apoptotic program. Emerging evidence also highlights the importance of organelle communication in disorders such as Alzheimer's disease, pulmonary arterial hypertension, cancer, skeletal and cardiac muscle dysfunction. Here, we provide an overview of the current literature on organelle communication and the link to human pathologies.
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile.
authors.forename: Roberto
authors.initials: R
authors.lastname: Bravo-Sagua
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile.
authors.forename: Natalia
authors.initials: N
authors.lastname: Torrealba
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile.
authors.forename: Felipe
authors.initials: F
authors.lastname: Paredes
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile.
authors.forename: Pablo E
authors.initials: PE
authors.lastname: Morales
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile.
authors.forename: Christian
authors.initials: C
authors.lastname: Pennanen
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile.
authors.forename: Camila
authors.initials: C
authors.lastname: López-Crisosto
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Troncoso
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile; Instituto de Investigación en Ciencias Ontológicas, Facultad Odontología, Universidad de Chile, Santiago 8380492, Chile; Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
authors.forename: Alfredo
authors.initials: A
authors.lastname: Criollo
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile.
authors.forename: Mario
authors.initials: M
authors.lastname: Chiong
authors.affiliation: Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hill
authors.affiliation: Department of Cell Biology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
authors.forename: Thomas
authors.initials: T
authors.lastname: Simmen
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile; Instituto Ciencias Biomedicas, Facultad Medicina, Universidad de Chile, Santiago 8380492, Chile.
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Quest
authors.affiliation: Advanced Center for Chronic Diseases (ACCDiS) & Center for Molecular Studies of the Cell, Facultad de Ciencias Quimicas y Farmaceuticas & Facultad de Medicina, Universidad de Chile, Santiago 8380492, Chile; Instituto Ciencias Biomedicas, Facultad Medicina, Universidad de Chile, Santiago 8380492, Chile; Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX 75235, USA. Electronic address: slavander@uchile.cl.
authors.forename: Sergio
authors.initials: S
authors.lastname: Lavandero
mesh_terms: D020013:Calcium Signaling / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D050356:Lipid Metabolism; D008928:Mitochondria / Q000378:metabolism; D015388:Organelles / Q000378:metabolism* / Q000473:pathology*; D015398:Signal Transduction
keywords: Calcium signaling; Endoplasmic reticulum; Mitochondria; Organelles