title: Catalytic C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds.
abstract: A copper(I)-catalyzed, regioselective C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds using Togni's reagent was developed. Diverse substrates, including enones as well as α,β-unsaturated esters, thioesters, and amides, stereospecifically afforded the corresponding (E)-α-trifluoromethylated products in moderate to high yields. Further, this method was applied to the C-H trifluoromethylation of drugs.
authors.affiliation: Department of Chemistry, Northeast Normal University , Changchun 130024, China.
authors.forename: Zhongxue
authors.initials: Z
authors.lastname: Fang
authors.forename: Yongquan
authors.initials: Y
authors.lastname: Ning
authors.forename: Pengbing
authors.initials: P
authors.lastname: Mi
authors.forename: Peiqiu
authors.initials: P
authors.lastname: Liao
authors.forename: Xihe
authors.initials: X
authors.lastname: Bi
mesh_terms: D000577:Amides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D007454:Iodides / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000577:Amides; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; D007454:Iodides; D007659:Ketones; D003300:Copper; C073870:cuprous iodide