title: Prevalence and prognostic value of headache on early mortality in acute stroke: the Dijon Stroke Registry.
abstract: OBJECTIVE
  To evaluate the prevalence of headache at onset and its association with 1-month mortality in stroke patients.
  
  
  METHODS
  All patients with stroke in Dijon, France (2006-2011), were prospectively identified using a population-based registry. Cox regression models were used to evaluate the association between headache and 30-day all-cause mortality.
  
  
  RESULTS
  Among 1411 stroke patients, data about headache were obtained for 1391 (98.6%) of whom 1185 had an ischemic stroke (IS), 201 had an intracerebral hemorrhage (ICH) and five had a stroke of undetermined etiology. Headache was found in 253 (18.2%) patients and was more frequent in those with ICH than in those with IS (46.3% vs 13.5%, p < 0.001). Overall 30-day mortality was 11.7%, and was greater for patients with than those without headache (17.0% vs 10.5%, unadjusted HR 1.70; 95% CI 1.20-2.41, p = 0.003). In multivariable analysis, an association between headache and 30-day mortality was observed (HR 1.51; 95% CI 1.02-2.25, p = 0.042). In stratified analyses, headache was associated with 30-day mortality in ICH (HR 2.09; 95% CI 1.18-3.71, p = 0.011) but not in IS (HR 1.01; 95% CI 0.53-1.92, p = 0.97).
  
  
  CONCLUSIONS
  Headache at stroke onset is associated with a higher risk of early mortality in patients with ICH.
authors.affiliation: Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France.
authors.forename: Victor
authors.initials: V
authors.lastname: Abadie
authors.affiliation: Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France.
authors.forename: Agnès
authors.initials: A
authors.lastname: Jacquin
authors.affiliation: Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Daubail
authors.affiliation: Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Vialatte
authors.affiliation: Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Lainay
authors.affiliation: Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Durier
authors.affiliation: Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France.
authors.forename: Guy-Victor
authors.initials: GV
authors.lastname: Osseby
authors.affiliation: Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France.
authors.forename: Maurice
authors.initials: M
authors.lastname: Giroud
authors.affiliation: Dijon Stroke Registry, Department of Neurology, University Hospital and Medical School of Dijon, University of Burgundy, France ybejot@yahoo.fr.
authors.forename: Yannick
authors.initials: Y
authors.lastname: Béjot
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005602:France / Q000453:epidemiology; D006261:Headache / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D016016:Proportional Hazards Models; D012042:Registries; D020521:Stroke / Q000150:complications* / Q000401:mortality*
keywords: Epidemiology; headache; mortality; outcome; registry; stroke