title: Direct sp(3)C-H acroleination of N-aryl-tetrahydroisoquinolines by merging photoredox catalysis with nucleophilic catalysis.
abstract: Sequence catalysis merging photoredox catalysis (PC) and nucleophilic catalysis (NC) has been realized for the direct sp(3) C-H acroleination of N-aryl-tetrahydroisoquinoline (THIQ). The reaction was performed under very mild conditions and afforded products in 50-91% yields. A catalytic asymmetric variant was proved to be successful with moderate enantioselectivities (up to 83 : 17 er).
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China. wxiao@mail.ccnu.edu.cn.
authors.forename: Zhu-Jia
authors.initials: ZJ
authors.lastname: Feng
authors.forename: Jun
authors.initials: J
authors.lastname: Xuan
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Xia
authors.forename: Wei
authors.initials: W
authors.lastname: Ding
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Jia-Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: You-Quan
authors.initials: YQ
authors.lastname: Zou
authors.forename: Liang-Qiu
authors.initials: LQ
authors.lastname: Lu
authors.forename: Wen-Jing
authors.initials: WJ
authors.lastname: Xiao
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D055668:Photochemical Processes; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000737:chemistry*
chemical_list: D000588:Amines; D044005:Tetrahydroisoquinolines