title: Turn-on trivalent cation selective chemodosimetric probe to image native cellular iron pools.
abstract: A new turn-on cell permeable chemodosimetric probe has been developed and its application in the selective detection of trivalent cations (Fe(3+)/Cr(3+)/Al(3+)) at a sub-nanomolar level has been demonstrated. The selectivity of over a broad spectrum of mono- and divalent metal ions was established using fluorescence spectroscopy. Moreover, the changes in the absorption spectra of in the presence of trivalent cations enabled the most bio-relevant metal ion Fe(3+) over Cr(3+)/Al(3+) to be distinguished. The probe was found to be successful in the fluorescence imaging of native cellular iron pools. The fluorescence imaging of the native iron pools of banana pith further supported the high sensitivity of towards Fe(3+) present in living systems. To the best of our knowledge, this is the first example of a turn-on chemodosimetric probe to image native cellular Fe(3+) pools.
authors.affiliation: School of Basic Sciences, Indian Institute of Technology Mandi, Mandi-175001, H.P., India. rik@iitmandi.ac.in.
authors.forename: M
authors.initials: M
authors.lastname: Venkateswarulu
authors.forename: Trinetra
authors.initials: T
authors.lastname: Mukherjee
authors.forename: Subhrakanti
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Rik Rani
authors.initials: RR
authors.lastname: Koner
mesh_terms: D000535:Aluminum; D002176:Candida albicans / Q000737:chemistry* / Q000378:metabolism; D002857:Chromium; D005456:Fluorescent Dyes / Q000737:chemistry / Q000494:pharmacology*; D007097:Imines / Q000737:chemistry / Q000494:pharmacology*; D007501:Iron / Q000032:analysis* / Q000737:chemistry; D028521:Musa / Q000166:cytology; D018547:Plant Stems / Q000737:chemistry / Q000166:cytology / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D007097:Imines; D002857:Chromium; D000535:Aluminum; D007501:Iron