title: Local immunostimulation leading to rejection of accepted male skin grafts by female mice as a model for cancer immunotherapy.
abstract: Female mice of inbred strain CBA do not reject syngeneic male skin grafts even though they mount a T-cell response against the male-specific HY antigen. We show that local immunostimulation performed by injecting cytokines and Toll-like receptor ligands in close vicinity to the graft causes rejection. We feel that this approach should be tested in tumor-bearing human patients in combination with antitumor vaccination. Relief of intratumor immunosuppression may increase considerably the fraction of patients who respond to vaccination directed against tumor antigens recognized by T cells.
authors.affiliation: Ludwig Institute for Cancer Research, Brussels Branch, B-1200 Brussels, Belgium.
authors.forename: Christophe
authors.initials: C
authors.lastname: Bourdeaux
authors.forename: Christophe
authors.initials: C
authors.lastname: Lurquin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Jacquemart
authors.forename: Bernard
authors.initials: B
authors.lastname: Lethé
authors.forename: Francis
authors.initials: F
authors.lastname: Brasseur
authors.forename: Nicolas
authors.initials: N
authors.lastname: van Baren
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Baurain
authors.forename: Julian
authors.initials: J
authors.lastname: Dyson
authors.forename: Jacques
authors.initials: J
authors.lastname: Van Snick
authors.forename: Catherine
authors.initials: C
authors.lastname: Uyttenhove
authors.forename: Thierry
authors.initials: T
authors.lastname: Boon
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D016207:Cytokines / Q000009:adverse effects / Q000276:immunology; D017931:DNA Primers / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D006084:Graft Rejection / Q000139:chemically induced*; D007108:Immune Tolerance / Q000276:immunology*; D007114:Immunization / Q000009:adverse effects / Q000379:methods*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012737:Sex Factors; D016038:Skin Transplantation / Q000379:methods
chemical_list: D016207:Cytokines; D017931:DNA Primers
keywords: immunology; transplantation