title: Association study between IL-1β-511 C/T polymorphism and obsessive-compulsive disorder (OCD) in Chinese Han population.
abstract: OBJECTIVE
  This study investigated the potential association between Obsessive-Compulsive Disorder (OCD) and a functional polymorphism of IL-1beta-511 C/T in Chinese Han population.
  
  
  METHODS
  The authors genotyped the IL-1beta-511 C/T of 241 OCD patients and 444 healthy control subjects and then performed a case-control association analysis.
  
  
  RESULTS
  No difference was found in IL-1beta-511 C/T genotypic and allelic frequencies between OCD cases and controls (chi2 = 0.501, df = 2, P = 0.78 by genotype; chi2 = 0.487, df = 1, P = 0.49 by allele).
  
  
  CONCLUSIONS
  IL-1beta-511 polymorphism may not play a major role in the genetic predisposition to OCD in Chinese Han population. Given that this is an early investigation of this gene in OCD, further studies are required to draw firm conclusions.
authors.affiliation: Shandong University and Qingdao University, China.
authors.forename: Yongli
authors.initials: Y
authors.lastname: Bo
authors.affiliation: Qingdao University, Jinan, China.
authors.forename: Shiguo
authors.initials: S
authors.lastname: Liu
authors.affiliation: Qingdao University, Jinan, China.
authors.forename: Yingying
authors.initials: Y
authors.lastname: Yin
authors.affiliation: Qingdao University, Jinan, China.
authors.forename: Zusen
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Qingdao University, Jinan, China.
authors.forename: Jiajia
authors.initials: J
authors.lastname: Cui
authors.affiliation: Qingdao University, Jinan, China.
authors.forename: Jinbao
authors.initials: J
authors.lastname: Zong
authors.affiliation: Qingdao University, Jinan, China.
authors.forename: Xinhua
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Neurosurgery Department of Qilu Hospital, Brain Sciences Research Institute, Shandong University, Jinan, China.
authors.forename: Xingang
authors.initials: X
authors.lastname: Li
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D055815:Young Adult
chemical_list: D053583:Interleukin-1beta