title: Early development of broadly reactive HIV-1 neutralizing activity in elite neutralizers.
abstract: Broadly reactive neutralizing activity (brNA) against HIV-1 is observed in 10-30% of infected individuals and generally takes 2-4 years to develop. Here, we show that two elite neutralizers, infected through injecting drug use, developed brNA around the first year postseroconversion (post-SC), whereas criteria for elite brNA were fulfilled around 30 months post-SC. These results indicate that brNA does not necessarily require multiple years to develop and they should encourage the search for vaccines that can elicit protective humoral immunity.
authors.affiliation: aDepartment of Experimental Immunology and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam bCrucell Holland BV, Leiden cDepartment of Medical Microbiology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands dDepartment of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York eRagon Institute of MGH, MIT and Harvard, Charlestown, Massachusetts, USA.
authors.forename: Tom L G M
authors.initials: TL
authors.lastname: van den Kerkhof
authors.forename: Zelda
authors.initials: Z
authors.lastname: Euler
authors.forename: Marit J
authors.initials: MJ
authors.lastname: van Gils
authors.forename: Brigitte D
authors.initials: BD
authors.lastname: Boeser-Nunnink
authors.forename: Hanneke
authors.initials: H
authors.lastname: Schuitemaker
authors.forename: Rogier W
authors.initials: RW
authors.lastname: Sanders
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D015483:HIV Antibodies / Q000276:immunology*; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D018451:Homosexuality, Male; D006801:Humans; D056724:Immunity, Humoral; D008297:Male; D015819:Substance Abuse, Intravenous / Q000150:complications
chemical_list: D057134:Antibodies, Neutralizing; D015483:HIV Antibodies