title: Novel insight into the role of α-actinin-1 in rheumatoid arthritis.
abstract: The knowledge of rheumatoid arthritis (RA) pathology is rapidly advancing and becoming more and more complex, and a simple fact is that the major organ targeted by RA pathogenic factors is the synovium. It is well known that fibroblast-like synovial (FLS) cell is the major cell-type for constructing synovium. Following stimulation by pro-inflammatory cytokines, FLS cells are phenotypically changed to have the capability to proliferate abnormally. Recently we demonstrated that α-actinin-1 (ACTN1) gene is significantly increased in synovial tissues obtained from RA, as compared to osteoarthritis (OA). We therefore reviewed the literature about α-actinins (ACTNs) and we now propose that ACTN1 may function as a "terminal effector" of intracellular signalings initiated by tumor necrosis factor-α (TNF-α) and interleukin-1 (IL-1) in RA. Future research on ACTN1 may help to improve the current therapeutic and diagnostic strategies of RA.
authors.affiliation: Department of Rheumatology, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine), Guangzhou, Guangdong 510006, China; Department of Metabolic Diseases, Faculty of Medicine, University Medical Centre Utrecht, Utrecht, Netherlands.
authors.forename: Run-Yue
authors.initials: RY
authors.lastname: Huang
authors.forename: Qing-Chun
authors.initials: QC
authors.lastname: Huang
authors.forename: Boudewijn Marius Theodoor
authors.initials: BM
authors.lastname: Burgering
mesh_terms: D000185:Actinin / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D020869:Gene Expression Profiling; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism; D008954:Models, Biological; D015398:Signal Transduction
chemical_list: D000185:Actinin