title: Expansion of range of joint motion following treatment of systemic sclerosis with tocilizumab.
abstract: Systemic sclerosis (SSc) presents stiffness of extremities due to sclerosis of the tissue especially at fingers, hands, and forearms. Here we report the case of a patient with diffuse cutaneous SSc who was administered anti-interleukin-6 receptor antibody tocilizumab (TCZ). Skin condition of SSc is evaluated by pinching the skin according to the Rodnan skin score, but sometimes tissue atrophy results in overestimation of the condition. To understand how the extremities softened after initiation of TCZ, we observed mobility of extremities. Range of motion (ROM) of joints was measured every four months after initiation of TCZ. The patient presented not only reduction of Rodnan score but also amelioration of mobility of extremities. The Rodnan skin score reduced from 35 to 7 within sixteen months, and ROM of most joints except ankle was expanded.
authors.affiliation: Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine , 2-2 Yamada-oka, 565-0871, Suita City, Osaka , Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Shima
authors.forename: Naoki
authors.initials: N
authors.lastname: Hosen
authors.forename: Toru
authors.initials: T
authors.lastname: Hirano
authors.forename: Junsuke
authors.initials: J
authors.lastname: Arimitsu
authors.forename: Sumiyuki
authors.initials: S
authors.lastname: Nishida
authors.forename: Keisuke
authors.initials: K
authors.lastname: Hagihara
authors.forename: Masashi
authors.initials: M
authors.lastname: Narazaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ogata
authors.forename: Toshio
authors.initials: T
authors.lastname: Tanaka
authors.forename: Tadamitsu
authors.initials: T
authors.lastname: Kishimoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kumanogoh
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007596:Joints / Q000187:drug effects* / Q000503:physiopathology; D008875:Middle Aged; D016059:Range of Motion, Articular / Q000187:drug effects* / Q000502:physiology; D012595:Scleroderma, Systemic / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C502936:tocilizumab
keywords: Range of joint motion; Systemic sclerosis; Tocilizumab