title: Mean platelet volume in relation to carotid atherosclerosis in normotensive, euglycemic, and normolipidemic Chinese middle-aged and elderly adults.
abstract: We investigated whether mean platelet volume (MPV) is independently associated with the carotid intima-media thickness (cIMT) in normotensive, euglycemic, and normolipidemic middle-aged and elderly adults. A total of 256 males and 398 females were enrolled from the Changfeng Study. Compared to male patients with MPV in the first quintile, male patients with MPV in the fifth quintile had greater cIMTs and higher prevalence of carotid plaque. After adjusting for conventional cardiovascular disease risk factors, male participants with MPV in the fifth quintile had a 1.669-fold increased risk of carotid plaques relative to those in the lowest quintiles. In female patients, the cIMTs and prevalence of carotid plaque were not significantly different among the groups. These results suggest that MPV is independently associated with carotid atherosclerosis in normotensive, euglycemic, and normolipidemic males. The MPV could be an easily measured marker of atherosclerosis for males.
authors.affiliation: Department of Endocrinology and Metabolism, Zhong Shan Hospital, Fudan University, Shanghai, China Department of Geriatrics, Zhong Shan Hospital, Fudan University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ma
authors.affiliation: Department of Endocrinology and Metabolism, Zhong Shan Hospital, Fudan University, Shanghai, China.
authors.forename: Huandong
authors.initials: H
authors.lastname: Lin
authors.affiliation: Department of Geriatrics, Zhong Shan Hospital, Fudan University, Shanghai, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
authors.affiliation: Department of Endocrinology and Metabolism, Zhong Shan Hospital, Fudan University, Shanghai, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.affiliation: Department of Ultrasonography, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Wanyuan
authors.initials: W
authors.lastname: He
authors.affiliation: Clinical Epidemiology Center, Zhong Shan Hospital, Fudan University, Shanghai, China.
authors.forename: Xuejuan
authors.initials: X
authors.lastname: Jin
authors.affiliation: Department of Clinical Nutrition, Zhong Shan Hospital, Fudan University, Shanghai, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Gao
authors.affiliation: Department of Biostatistics, College of Public Health, Fudan University, Shanghai, China.
authors.forename: Naiqing
authors.initials: N
authors.lastname: Zhao
authors.affiliation: Department of Endocrinology and Metabolism, Zhong Shan Hospital, Fudan University, Shanghai, China zhongshan_endo@126.com gao.xin@zs-hospital.sh.cn.
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
mesh_terms: D000368:Aged; D044466:Asian People; D002340:Carotid Artery Diseases / Q000097:blood / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D002681:China; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging; D012737:Sex Factors
keywords: carotid atherosclerosis; carotid intima–media thickness; carotid plaque; mean platelet volume