title: Comparing indicators of health and development of singleton young adults conceived with and without assisted reproductive technology.
abstract: OBJECTIVE
  To compare outcomes for young adults conceived by assisted reproductive technology (ART) with non-ART-conceived young adults.
  
  
  METHODS
  Cohort study.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Mothers and their offspring (aged 18-28 years) conceived by ART; mothers and their non-ART-conceived offspring, randomly selected from the same source population.
  
  
  METHODS
  Structured telephone interviews, one with mothers and another with their young adult offspring.
  
  
  METHODS
  Maternal report on young adult offspring hospitalizations and chronic illness accumulated over the first 18 years of their lives; young adult self-report on perceived current quality of life, body mass index, pubertal development, and educational achievement.
  
  
  RESULTS
  Of 1,480 eligible ART mothers, 80% were traced and contacted. Of those, 656 (55%) participated, reporting on 705 ART-conceived offspring; 269 (23%) declined participation and 262 (22%) did not respond. Of the participants, 84% consented to contact with their young adult offspring, of whom 547 (92%) participated. Random-digit dialing recruited 868 non-ART mothers and 549 offspring. Compared with non-ART young adults, the ART group had significant increases in three maternally reported outcomes: 1) hospital admissions, including those in the secondary school years; 2) atopic respiratory conditions; and 3) combined endocrine, nutritional, and metabolic disease ICD-10 category. Young adult reported outcomes were similar for both groups.
  
  
  CONCLUSIONS
  This study addresses gaps in knowledge of outcomes beyond adolescence for those conceived by ART. Results show few adverse outcomes in this large cohort of young adults, but additional assessment through clinical review is required to address issues unable to be examined in this study.
authors.affiliation: Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia. Electronic address: janehalliday.h@mcri.edu.au.
authors.forename: Jane
authors.initials: J
authors.lastname: Halliday
authors.affiliation: Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Australia.
authors.forename: Cate
authors.initials: C
authors.lastname: Wilson
authors.affiliation: Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
authors.forename: Karin
authors.initials: K
authors.lastname: Hammarberg
authors.affiliation: Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia; Department of Obstetrics and Gynaecology, Royal Women's Hospital, Parkville, Australia.
authors.forename: Lex W
authors.initials: LW
authors.lastname: Doyle
authors.affiliation: Cancer Epidemiology Centre, Cancer Council Victoria, Carlton, Australia.
authors.forename: Fiona
authors.initials: F
authors.lastname: Bruinsma
authors.affiliation: Monash IVF, Epworth Hospital, Richmond, Australia; Prince Henry's Institute and Department of Obstetrics and Gynaecology, Clayton, Australia; Monash Medical Centre, Clayton, Australia.
authors.forename: Robert
authors.initials: R
authors.lastname: McLachlan
authors.affiliation: Reproductive Services, Royal Women's Hospital, Parkville, Australia; Melbourne IVF, East Melbourne, Victoria, Australia.
authors.forename: John
authors.initials: J
authors.lastname: McBain
authors.affiliation: Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Australia.
authors.forename: Turi
authors.initials: T
authors.lastname: Berg
authors.affiliation: School of Population Health, University of Melbourne, Parkville, Australia; Jean Hailes Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
authors.forename: Jane R
authors.initials: JR
authors.lastname: Fisher
authors.affiliation: Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Australia; Department of Paediatrics, University of Melbourne, Parkville, Australia.
authors.forename: David
authors.initials: D
authors.lastname: Amor
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002908:Chronic Disease / Q000453:epidemiology*; D004522:Educational Status; D005260:Female; D006304:Health Status; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D011788:Quality of Life; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data*; D014739:Victoria / Q000453:epidemiology; D055815:Young Adult
keywords: Assisted reproductive techniques; chronic disease; cohort study; quality of life; young adults