title: Treg cells: a potential regulator for IL-22 expression?
abstract: Inteleurkin-22 (IL-22) is a IL-10 family cytokine member and is mainly produced by innate lymphoid cells (ILCs), Th17 cells, and Th22 cells. Previous studies have indicated that IL-23 and several transcription factors, including STAT3, RORγt, and the AhR are important stimulus. Recently, there is emerging evidence that Tregs can regulate IL-22 expression. In the review, we discuss the updated advancement on Tregs function and its regulatory role on IL-22 expression.
authors.affiliation: Medical College at Sun Yat‑Sen University Guangzhou, 510008, P. R. China.
authors.forename: Shuman
authors.initials: S
authors.lastname: Lin
authors.affiliation: Department of Rheumatology, Second Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, 310009, P. R. China.
authors.forename: Xuyan
authors.initials: X
authors.lastname: Yang
authors.affiliation: Medical College at Sun Yat‑Sen University Guangzhou, 510008, P. R. China.
authors.forename: Dian
authors.initials: D
authors.lastname: Liang
authors.affiliation: Division of Rheumatology, Department of Medicine at Penn State University Hershey College of Medicine Hershey, 17033, USA ; Institute of Immunology, Shanghai East Hospital at Tongji University Shanghai, 200120, P. R. China.
authors.forename: Song Guo
authors.initials: SG
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002450:Cell Communication; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D007378:Interleukins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism*; D000097043:Interleukin-22
chemical_list: D007378:Interleukins; D000097043:Interleukin-22
keywords: Interleukin-22; T helper cells; innate immune cells; regulatory (Treg) cells