title: Frequency of the transthyretin Val30Met mutation in the northern Swedish population.
abstract: By genotyping a large number of samples from the Northern Sweden Health and Disease Study cohort, a carrier frequency could be determined for the Skellefteå and Lycksele populations. A previous study of the amyloidogenic transthyretin mutation TTRV30M in Northern Sweden's endemic area has shown a large variation in carrier frequency and penetrance of the trait within the area. However, the estimations have been based on a small sample size within the different regions in the area and therefore, the wide variation in TTRV30M carrier frequency observed between the Lycksele and Skellefteå populations are uncertain. Based on a total of 3460 samples, the estimated overall carrier frequency in the two regions was 1.82% with a carrier frequency in the Skellefteå and Lycksele population of 1.63% and 2.02%, respectively. Thus, the previously reported extremely high frequency in the Lycksele region compared to that of the Skellefteå region could not be substantiated. However, it does not change the previous finding of a surprisingly higher carrier frequency in the population from endemic area of Northern Sweden compared to that reported from endemic areas in Portugal.
authors.affiliation: Department of Public Health and Clinical Medicine, Umeå University , Umeå , Sweden and.
authors.forename: Malin
authors.initials: M
authors.lastname: Olsson
authors.forename: Jenni
authors.initials: J
authors.lastname: Jonasson
authors.forename: Kristina
authors.initials: K
authors.lastname: Cederquist
authors.forename: Ole B
authors.initials: OB
authors.lastname: Suhr
mesh_terms: D028227:Amyloid Neuropathies, Familial / Q000453:epidemiology / Q000235:genetics*; D015331:Cohort Studies; D005787:Gene Frequency; D005820:Genetic Testing; D006579:Heterozygote; D006801:Humans; D020125:Mutation, Missense; D019683:Penetrance; D011228:Prealbumin / Q000235:genetics*; D013548:Sweden / Q000453:epidemiology
chemical_list: D011228:Prealbumin