title: Diagnosing dysglycemia in adolescents with polycystic ovary syndrome.
abstract: OBJECTIVE
  Screening for impaired glucose tolerance (IGT) is recommended for adolescents with polycystic ovary syndrome (PCOS) with oral glucose tolerance test (OGTT). Whether glycated hemoglobin (HbA1c) can be used for screening in this patient population is unknown. We sought to determine the utility of HbA1c and 2-hour OGTT for diagnosing dysglycemia in adolescents with PCOS.
  
  
  METHODS
  This was a retrospective cohort study of 68 adolescents with PCOS seen in the Boston Children's Hospital Division of Adolescent Medicine between 2008 and 2011 and not known to have diabetes. Prevalence of dysglycemia (impaired fasting glucose, IGT, increased risk for diabetes, or diabetes mellitus as diagnosed by fasting plasma glucose, 2-hour OGTT, and/or HbA1c) and sensitivity and specificity of HbA1c for diagnosing dysglycemia compared with OGTT were assessed.
  
  
  RESULTS
  Twenty-four participants had abnormal glucose testing, including one participant (1.5%) who met criteria for diabetes mellitus and 23 participants (34%) who met criteria for impaired fasting glucose/IGT/prediabetes. More patients were identified as having dysglycemia by HbA1c than OGTT. Compared with OGTT, HbA1c had a sensitivity of 60% and a specificity of 69% for diagnosing dysglycemia.
  
  
  CONCLUSIONS
  In adolescents with PCOS, HbA1c had moderate sensitivity and specificity for detecting dysglycemia compared with OGTT. Clinicians should be aware that both tests have benefits and limitations, and the optimal test for follow-up requires further study.
authors.affiliation: Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts. Electronic address: holly.gooding@childrens.harvard.edu.
authors.forename: Holly Catherine
authors.initials: HC
authors.lastname: Gooding
authors.affiliation: Clinical Research Center, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Carly
authors.initials: C
authors.lastname: Milliren
authors.affiliation: Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Michelle
authors.initials: M
authors.lastname: St Paul
authors.affiliation: Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts; Division of Endocrinology, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: M Joan
authors.initials: MJ
authors.lastname: Mansfield
authors.affiliation: Division of Adolescent and Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts; Division of Gynecology, Boston Children's Hospital, Boston, Massachusetts.
authors.forename: Amy
authors.initials: A
authors.lastname: DiVasta
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001900:Boston; D015897:Comorbidity; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis* / Q000453:epidemiology; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000453:epidemiology; D011236:Prediabetic State / Q000175:diagnosis* / Q000453:epidemiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012741:Sexual Maturation / Q000502:physiology
chemical_list: D006442:Glycated Hemoglobin
keywords: Adolescent; Diabetes; Polycystic ovarian syndrome; Screening