title: Significant correlation between uric acid levels and flow-mediated dilatation in patients with masked hypertension.
abstract: BACKGROUND
  Serum uric acid (UA) level is associated with prognosis in cardiovascular disorders such as sustained hypertension, diabetes mellitus and chronic kidney diseases. Increased UA levels in sustained hypertension may reflect early renal vascular alterations. However, it remains unclear if serum UA is associated with endothelial dysfunction in masked hypertensive patients.
  
  
  METHODS
  A total of 100 individuals (57% men and 43% women; mean 45 ± 8 years) with masked hypertension were included in the present study. The clinical and laboratory data were collected. Endothelial function was estimated by flow-mediated dilatation (FMD) of the brachial artery and expressed as percentage change relative to baseline diameter.
  
  
  RESULTS
  Univariate regression analysis showed that the FMD was significantly negative correlated with uric acid (r = -0.300, p = 0.002), ambulatory 24-h systolic blood pressure (SBP) (r = -0.275, p = 0.008), hs-CRP (r = -0.222, p = 0.033) and diastolic aortic diameter (r = -0.243, p = 0.019). In multivariate linear regression analysis, only uric acid levels and ambulatory 24-h SBP were significantly associated with FMD.
  
  
  CONCLUSIONS
  There was an independent correlation between UA and FMD, and a higher UA level was related to worse endothelial function which may contribute to hypertension and cardiovascular morbidity.
authors.affiliation: Department of Cardiology, Gaziantep State Hospital , Gaziantep , Turkey .
authors.forename: Isa
authors.initials: I
authors.lastname: Sincer
authors.forename: E
authors.initials: E
authors.lastname: Kurtoglu
authors.forename: M
authors.initials: M
authors.lastname: Calıskan
authors.forename: E
authors.initials: E
authors.lastname: Akkaya
authors.forename: E
authors.initials: E
authors.lastname: Vuruskan
authors.forename: M
authors.initials: M
authors.lastname: Küçükosmanoglu
authors.forename: F Yılmaz
authors.initials: FY
authors.lastname: Çoşkun
authors.forename: M F
authors.initials: MF
authors.lastname: Inci
authors.forename: A
authors.initials: A
authors.lastname: Zorlu
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D003920:Diabetes Mellitus / Q000503:physiopathology; D004106:Dilatation / Q000379:methods; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D059468:Masked Hypertension / Q000097:blood / Q000175:diagnosis*; D008875:Middle Aged; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
keywords: Endothelial function; flow-mediated dilatation; masked hypertension; uric acid