title: [Pharmacovigilance update].
abstract: The main pharmacovigilance updates in 2013 are reviewed. Nitrofurantoin: lower efficacy and an increased risk of adverse events when creatinine clearance is below 60 ml/min. Dabigatran: contraindicated in patients with mechanical heart valves. Azithromycin: QT prolongation and increased risk of death. Zolpidem: towards a lower dosage. Roflumilast: avoid in patients known or at risk for mood disorders. Retigabine: indication restricted to last-line use and new monitoring requirements after reports of pigment changes in retina and other tissues. Telaprevir and rituximab: severe mucocutaneous reactions. Fingolimod: rare cases of progressive multifocal leucoencephalopathy. Tolvaptan: potential for hepatotoxicity. Nicotinic acid/laropiprant: suspension of marketing authorization as benefits no longer outweigh risks.
authors.affiliation: Département des laboratoires CHUV, Lausanne. leonore.diezi@chuv.ch
authors.forename: Léonore
authors.initials: L
authors.lastname: Diezi
authors.affiliation: Département des laboratoires CHUV, Lausanne.
authors.forename: Delphine
authors.initials: D
authors.lastname: Renard
authors.affiliation: Département des laboratoires CHUV, Lausanne.
authors.forename: Laura E
authors.initials: LE
authors.lastname: Rothuizen
authors.affiliation: Département des laboratoires CHUV, Lausanne.
authors.forename: Françoise
authors.initials: F
authors.lastname: Livio
mesh_terms: D000631:Aminopyridines / Q000009:adverse effects; D058846:Antibodies, Monoclonal, Murine-Derived / Q000009:adverse effects; D017963:Azithromycin / Q000009:adverse effects; D001549:Benzamides / Q000009:adverse effects; D002219:Carbamates / Q000009:adverse effects; D003521:Cyclopropanes / Q000009:adverse effects; D006801:Humans; D009582:Nitrofurantoin / Q000009:adverse effects*; D009842:Oligopeptides / Q000009:adverse effects; D060735:Pharmacovigilance; D010655:Phenylenediamines / Q000009:adverse effects; D011725:Pyridines / Q000009:adverse effects; D000069283:Rituximab; D000077334:Zolpidem
chemical_list: D000631:Aminopyridines; D058846:Antibodies, Monoclonal, Murine-Derived; D001549:Benzamides; D002219:Carbamates; D003521:Cyclopropanes; D009842:Oligopeptides; D010655:Phenylenediamines; D011725:Pyridines; C424423:Roflumilast; C101866:ezogabine; D000069283:Rituximab; C486464:telaprevir; D000077334:Zolpidem; D017963:Azithromycin; D009582:Nitrofurantoin
vernacular_title: Pharmacovigilance.