title: Anti-ictogenic effects of the corticotropin-releasing factor-like peptide in the pentylenetetrazole model of seizure in brain slices.
abstract: The present study provides evidence for anti-ictogenic activity of the mystixin 7 (MTX) mini-peptide in the pentylenetetrazole model of seizure. MTX was effective in inhibiting/suppressing ictal- and interictal-like activities over a long period of time (during 60-80min). The peptide's anti-ictogenic effects were concentration- and time-dependent. An enzymatic treatment of MTX was accompanied by a decrease of the frequency pattern of epileptiform discharges, but their total blockade did not occurred. These findings indicate that the MTX mini-peptide has pronounced anti-ictogenic properties.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Science, Nab. Makarova, 6, Saint-Petersburg 199034, Russia. Electronic address: mok@inbox.ru.
authors.forename: Anatoly A
authors.initials: AA
authors.lastname: Mokrushin
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects*; D003292:Convulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D018709:Statistics, Nonparametric
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D009842:Oligopeptides; C110632:mystixin 7; D010433:Pentylenetetrazole
keywords: AMPA; Brain slices; EPSP; Epileptiform discharges; Mystixin; NMDA