title: An in vivo study of the effects on serum glucose, amylase and histopathology of the feline pancreatic tissue treated by focused ultrasound.
abstract: Pancreatic cancer is one of the most malignant neoplasms originating in the digestive system. Focused ultrasound (FUS) treatment instead of the surgery operation has been used to treat Pancreatic cancer noninvasively in clinical trials. The endocrine and exocrine glands in pancreas provide the two unique functions for a person to be healthy. It is critically important to find out if the FUS treatment can still keep the normal functions of the two glands. The goal of this study is to examine and analyze changes in histopathology and serum glucose and amylase levels of the targeted in-vivo felines after the FUS treatment. Various percentage volumes of pancreas of felines were insonified. The FUS treatment (7.5 MHz of central frequency; 5 W of acoustical power; transducer f-number = 0.33; 6 s insonification time per point) effectively generated coagulative necrosis at the insonified site while leaving tissue outside the insonified site intact. It was also observed that all felines endured well with the FUS treatment; changes introduced to pancreatic tissue after up to 50% of a pancreas by volume was insonified by the FUS procedure did not affect its normal endocrine and exocrine functions.
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Mao
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Liaoqiong
authors.initials: L
authors.lastname: Fang
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Ai
authors.affiliation: National Engineering Research Center of Ultrasound Medicine, Chongqing, China.
authors.forename: Chongyan
authors.initials: C
authors.lastname: Li
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Zhibiao
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Physics, University of Vermont, Burlington, Vermont, United States of America.
authors.forename: Junru
authors.initials: J
authors.lastname: Wu
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Bai
authors.affiliation: State Key Laboratory of Ultrasound Engineering in Medicine Co-founded by Chongqing and the Ministry of Science and Technology, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
authors.forename: Faqi
authors.initials: F
authors.lastname: Li
mesh_terms: D000681:Amylases / Q000097:blood*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002415:Cats; D009336:Necrosis / Q000209:etiology; D010179:Pancreas / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000628:therapy; D012449:Safety; D014464:Ultrasonic Therapy / Q000009:adverse effects
chemical_list: D001786:Blood Glucose; D000681:Amylases