title: Copper-containing mesoporous bioactive glass coatings on orbital implants for improving drug delivery capacity and antibacterial activity.
abstract: Anophthalmic orbit restoration with artificial implants is usually accompanied with the risks of bacterial penetration and implant exposure. Here, we develop a facile evaporation-inducing self-assembly approach to modify the porous hydroxyapatite (pHA) orbital implants by using sol-gel derived CuO-containing mesoporous bioactive glass (Cu-MBG). The Cu-MBG coatings with 0-5 mol% CuO were prepared in the pore wall of pHA by immersion-evaporation-ageing route in the sol precursor of Cu-MBG. Brunauer-Emmett-Teller and Barrette-Joyner-Halenda analyses showed that the specific surface area and pore volume were slightly decreased with increasing CuO content, while the Cu-MBG-modified pHA maintained a sustained release of ofloxacin and significantly inhibited the bacterial viability (Staphylococcus aureus and Escherichia coli). These studies demonstrate that the Cu-MBG modification provides an effective and facile strategy to endow combined biological performances of pHA orbital implants and potentially reduce implant-related side effects.
authors.affiliation: Eye Center of the 2nd Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China, yejuan@zju.edu.cn.
authors.forename: Juan
authors.initials: J
authors.lastname: Ye
authors.forename: Jinjing
authors.initials: J
authors.lastname: He
authors.forename: Changjun
authors.initials: C
authors.lastname: Wang
authors.forename: Ke
authors.initials: K
authors.lastname: Yao
authors.forename: Zhongru
authors.initials: Z
authors.lastname: Gou
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000493:pharmacokinetics; D003300:Copper / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D005898:Glass / Q000737:chemistry*; D020273:Orbital Implants; D016062:Porosity
chemical_list: D000900:Anti-Bacterial Agents; D003300:Copper