title: Porcine cholecyst-derived scaffold promotes full-thickness wound healing in rabbit.
abstract: Graft-assisted healing is an important strategy for treating full-thickness skin wounds. This study evaluated the properties of porcine cholecyst-derived scaffold and its use for treating full-thickness skin wound in rabbit. The physical properties of cholecyst-derived scaffold were congenial for skin-graft application. Compared to a commercially available skin-graft substitute made of porcine small intestinal submucosa, the cholecyst-derived scaffold was rich in natural biomolecules like elastin and glycosaminoglycans. When used as a xenograft, it promoted healing with excess cell proliferation at early phases and acceptable collagen deposition in the later remodelling phases.
authors.affiliation: Division of Experimental Pathology Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
authors.forename: Deepa
authors.initials: D
authors.lastname: Revi
authors.affiliation: Division of Experimental Pathology Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
authors.forename: Vadavanath Prabhakaran
authors.initials: VP
authors.lastname: Vineetha
authors.affiliation: Division of Experimental Pathology Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
authors.forename: Jaseer
authors.initials: J
authors.lastname: Muhamed
authors.affiliation: Division of Experimental Pathology Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
authors.forename: Akhila
authors.initials: A
authors.lastname: Rajan
authors.affiliation: Division of Experimental Pathology Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
authors.forename: Thapasimuthu Vijayamma
authors.initials: TV
authors.lastname: Anilkumar
keywords: Wound healing; cholecyst-derived scaffold; collagen; extracellular matrix; graft-assisted healing; skin graft