title: Clinical usefulness of oral supplementation with alpha-lipoic Acid, curcumin phytosome, and B-group vitamins in patients with carpal tunnel syndrome undergoing surgical treatment.
abstract: We investigated the clinical usefulness of oral supplementation with a combination product containing alpha-lipoic acid, curcumin phytosome, and B-group vitamins in 180 patients with carpal tunnel syndrome (CTS), scheduled to undergo surgical decompression of the median nerve. Patients in Group A (n = 60) served as controls and did not receive any treatment either before or after surgery. Patients in Group B (n = 60) received oral supplementation twice a day for 3 months both before and after surgery (totaling 6 months of supplementation). Patients in Group C (n = 60) received oral supplementation twice a day for 3 months before surgery only. Patients in Group B showed significantly lower nocturnal symptoms scores compared with Group A subjects at both 40 days and 3 months after surgery (both P values <0.05). Moreover, patients in Group B had a significantly lower number of positive Phalen's tests at 3 months compared with the other study groups (P < 0.05). We conclude that oral supplementation with alpha-lipoic acid, curcumin phytosome, and B-group vitamins twice a day both before and after surgery is safe and effective in CTS patients scheduled to undergo surgical decompression of the median nerve.
authors.affiliation: Hand Surgery Unit, Plastic Surgery Department, MultiMedica Holding S.p.A, Via Milanese, Sesto San Giovanni, 300-20099 Milan, Italy.
authors.forename: Giorgio
authors.initials: G
authors.lastname: Pajardi
authors.affiliation: Hand Surgery Unit, Plastic Surgery Department, MultiMedica Holding S.p.A, Via Milanese, Sesto San Giovanni, 300-20099 Milan, Italy.
authors.forename: Paola
authors.initials: P
authors.lastname: Bortot
authors.affiliation: Hand Surgery Unit, Plastic Surgery Department, MultiMedica Holding S.p.A, Via Milanese, Sesto San Giovanni, 300-20099 Milan, Italy.
authors.forename: Veronica
authors.initials: V
authors.lastname: Ponti
authors.affiliation: Hand Surgery Unit, Plastic Surgery Department, MultiMedica Holding S.p.A, Via Milanese, Sesto San Giovanni, 300-20099 Milan, Italy.
authors.forename: Chiara
authors.initials: C
authors.lastname: Novelli