title: Canine bone marrow stromal cells promote functional recovery in mice with spinal cord injury.
abstract: Regenerative therapy has begun to be clinically applied in humans and dogs to treat neurological disorders, such as spinal cord injury (SCI). Here, we show the therapeutic potential of transplantation of cultured canine bone marrow stromal cells (BMSCs) into mice with SCI. Canine BMSC transplantation therapy was performed, immediately after the spinal cord was injured. Canine BMSC therapy enhanced functional recovery of the hind limbs in mice with SCI. Nestin-positive cells were observed only in the lesion of mice with SCI that received BMSCs. These results suggest that canine BMSCs promote functional recovery in mice with SCI and that migration of nestin-positive cells may contribute to the efficacy of the BMSC treatment.
authors.affiliation: The United Graduate School of Veterinary Science, Yamaguchi University, 1677-1 Yoshida, Yamaguchi 753-8515, Japan.
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Oda
authors.forename: Kenji
authors.initials: K
authors.lastname: Tani
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Asari
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Quintanilha
authors.forename: Tomoya
authors.initials: T
authors.lastname: Haraguchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Momota
authors.forename: Masaaki
authors.initials: M
authors.lastname: Katayama
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Itamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakazawa
authors.forename: Yasuho
authors.initials: Y
authors.lastname: Taura
mesh_terms: D000818:Animals; D017931:DNA Primers / Q000235:genetics; D004285:Dogs; D007150:Immunohistochemistry; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D051379:Mice; D064231:Nestin / Q000378:metabolism; D016133:Polymerase Chain Reaction; D013119:Spinal Cord Injuries / Q000628:therapy*; D058630:Spinal Cord Regeneration / Q000502:physiology*; D014183:Transplantation, Heterologous
chemical_list: D017931:DNA Primers; C577485:Nes protein, mouse; D064231:Nestin