title: Redox-mediated signal transduction by cardiovascular Nox NADPH oxidases.
abstract: The only known function of the Nox family of NADPH oxidases is the production of reactive oxygen species (ROS). Some Nox enzymes show high tissue-specific expression and the ROS locally produced are required for synthesis of hormones or tissue components. In the cardiovascular system, Nox enzymes are low abundant and function as redox-modulators. By reacting with thiols, nitric oxide (NO) or trace metals, Nox-derived ROS elicit a plethora of cellular responses required for physiological growth factor signaling and the induction and adaptation to pathological processes. The interactions of Nox-derived ROS with signaling elements in the cardiovascular system are highly diverse and will be detailed in this article, which is part of a Special Issue entitled "Redox Signalling in the Cardiovascular System".
authors.affiliation: Institut für Kardiovaskuläre Physiologie, Goethe-Universität Frankfurt, Germany. Electronic address: r.brandes@em.uni-frankfurt.de.
authors.forename: Ralf P
authors.initials: RP
authors.lastname: Brandes
authors.affiliation: Giessen University Lung Center, Justus-Liebig-Universität, Gießen, Germany.
authors.forename: Norbert
authors.initials: N
authors.lastname: Weissmann
authors.affiliation: Institut für Kardiovaskuläre Physiologie, Goethe-Universität Frankfurt, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Schröder
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000378:metabolism*; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism*; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D017382:Reactive Oxygen Species; D019255:NADPH Oxidases
keywords: Hydrogen peroxide; NADPH oxidase; Nitric oxide; Oxidative stress; Redox-regulation; Thiol