title: Genomic alterations in Warthin tumors of the parotid gland.
abstract: Despite the fact that Warthin tumors are the second most common type of benign salivary gland tumors, information regarding genetic alterations is extremely limited, and the tumorigenesis of these tumors has not been elucidated. The present results of the largest series of 30 tumors analyzed by comparative genomic hybridization (CGH) to date confirmed previous genetic findings and identified significant new candidate regions. The most commonly observed alterations were deletions of the short arm of chromosome 8, followed by deletions on 9p. Further representative changes were deletions on 16p and 22q with the minimal overlapping region at 16p12p13.1 and 22q12.1q12.3. Moreover, we indicated two different patterns of chromosomal aberrations. One group harbors deletions on 8p partly apparent with deletions on 9q, 11q 15q, 16p and 22. The second group shows gains on 22, partly apparent with gains on 1p and 20q and deletions on 9p. This leads to the assumption that Warthin tumors, in particular those with a high number of alterations, can be divided into two different genetic groups based on the pattern of numerical chromosomal aberrations. Further studies should address whether these subgroups also reflect a different clinical presentation.
authors.affiliation: Department of Otolaryngology, Saarland University Medical Center, D-66421 Homburg/Saar, Germany.
authors.forename: Silke
authors.initials: S
authors.lastname: Wemmert
authors.affiliation: Department of Otolaryngology, Saarland University Medical Center, D-66421 Homburg/Saar, Germany.
authors.forename: Vivienne
authors.initials: V
authors.lastname: Willnecker
authors.affiliation: Department of Otolaryngology, Saarland University Medical Center, D-66421 Homburg/Saar, Germany.
authors.forename: Birgit
authors.initials: B
authors.lastname: Sauter
authors.affiliation: Department of Otolaryngology, Saarland University Medical Center, D-66421 Homburg/Saar, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schuh
authors.affiliation: Department of Otolaryngology, Saarland University Medical Center, D-66421 Homburg/Saar, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Brunner
authors.affiliation: Institute of Pathology, Saarland University Medical Center, D-66421 Homburg/Saar, Germany.
authors.forename: Rainer Maria
authors.initials: RM
authors.lastname: Bohle
authors.affiliation: Department of Neurosurgery, Saarland University Medical Center, D-66421 Homburg/Saar, Germany.
authors.forename: Steffi
authors.initials: S
authors.lastname: Urbschat
authors.affiliation: Department of Otolaryngology, Saarland University Medical Center, D-66421 Homburg/Saar, Germany.
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schick
mesh_terms: D000235:Adenolymphoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D055028:Comparative Genomic Hybridization; D005260:Female; D015894:Genome, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization / Q000379:methods; D010307:Parotid Neoplasms / Q000235:genetics*; D055815:Young Adult