title: Comparison of 1H-19F two-dimensional NMR scalar coupling correlation pulse sequences.
abstract: The effectiveness of hetero-COSY, HETCOR, HMQC, and HSQC two-dimensional NMR pulse sequences for detection of (19)F-(1)H correlations by scalar coupling was evaluated on monofluorinated and polyfluorinated test compounds. All four of these sequences were effective in observing (1)H-(19)F correlations, using either (19) F or (1)H as the observe nucleus. All four sequences were amenable, to some degree, to adjustment to observe larger or smaller couplings preferentially. A 1/2J echo filter was effectively applied to remove artifacts from (2)JFF strong coupling. The HETCOR experiments afforded the best overall combination of sensitivity, resolution and selectivity for JHF.
authors.affiliation: Experimental Station, DuPont Central Research and Development, Wilmington, DE, USA.
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Marchione
authors.forename: Rebecca J
authors.initials: RJ
authors.lastname: Dooley
authors.forename: Breanna
authors.initials: B
authors.lastname: Conklin
keywords: 19F; 1H; 2D NMR; 2JFF strong coupling; HETCOR; HMBC; HMQC; HSQC; NMR; hetero-COSY