title: Anionic porphyrin as a new powerful cell death inducer of Tobacco Bright Yellow-2 cells.
abstract: For the first time, the behaviour of tobacco cell suspensions submitted to four porphyrins was described. The potential killer effect of these photosensitizers on tobacco cells was evaluated. Biological results were correlated with photophysical properties and the reactive oxygen species production capacity of tested compounds. Surprisingly, the anionic free-base porphyrin showed the strongest phototoxic effect.
authors.affiliation: Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, 123 avenue Albert Thomas, 87060 Limoges, France. stephanie.lhez@unilim.fr.
authors.forename: C
authors.initials: C
authors.lastname: Riou
authors.forename: C A
authors.initials: CA
authors.lastname: Calliste
authors.forename: A
authors.initials: A
authors.lastname: Da Silva
authors.forename: D
authors.initials: D
authors.lastname: Guillaumot
authors.forename: O
authors.initials: O
authors.lastname: Rezazgui
authors.forename: V
authors.initials: V
authors.lastname: Sol
authors.forename: S
authors.initials: S
authors.lastname: Leroy-Lhez
mesh_terms: D016923:Cell Death / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D053938:DNA Fragmentation / Q000187:drug effects / Q000528:radiation effects; D003624:Darkness; D006861:Hydrogen Peroxide / Q000378:metabolism; D008027:Light; D055668:Photochemical Processes; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D011166:Porphyrins / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013057:Spectrum Analysis; D014026:Nicotiana / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology / Q000528:radiation effects; D014867:Water / Q000737:chemistry
chemical_list: D017319:Photosensitizing Agents; D011166:Porphyrins; D017382:Reactive Oxygen Species; D014867:Water; D006861:Hydrogen Peroxide