title: HER-2/neu Marker Examination using Immunohistochemical Method in Patients Suffering from Gastric Adenocarcinoma.
abstract: Gastric adenocarcinoma is the second leading cause of death due to cancer in the world and in advanced stages the prognosis is poor even with current therapies. Over-expression of HER-2/neu has been seen in several cancers such as gastric cancer and its expression is associated with poor prognosis. The aim of this study is to evaluate the over-expression of HER-2/neu in gastric biopsy samples of patients with gastric carcinoma diagnosis; and to evaluate its probable relationship with clinical and pathological findings. The over-expression of HER-2/neu was examined retrospectively by immunohistochemistry method in 60 paraffin embedded samples collected in Babol, Iran, between 2010 and 2011. The over-expression of HER-2/neu has been observed in 6 patients (10%) and this over-expression was greater in the intestinal type of gastric adenocarcinoma than the diffuse type (12% vs. 6%); however, no statistically significant correlation between HER-2/neu expression and subtype, degree of differentiation, tumor type and age was observed. This over-expression was greater in differentiated types than undifferentiated types (18% vs. 5%).
authors.affiliation: Department of Pathology, Rohani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Kourosh
authors.initials: K
authors.lastname: Movagharnejad
authors.affiliation: Department of Pathology, Rohani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Sharbatdaran
authors.affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
authors.forename: Shahryar
authors.initials: S
authors.lastname: Sheffaee
authors.affiliation: Department of Internal Medicine , Rohani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Kashifard
authors.affiliation: Department of Hematology and Oncology, Rohani Hospital, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Sadegh
authors.initials: S
authors.lastname: Sedaghat
keywords: HER-2/neu; gastric cancer; immunohistochemistry