title: Detection and complete genome characterization of human enterovirus 118 from children with acute respiratory disease in China.
abstract: Enterovirus 118 (EV-118) within species HEV-C was detected in two 5-month-old boys with pneumonia in China. The EV-118 from both cases was genetically closer to ISR10 strain from Israel than to PER161 strain from Peru based on VP1 gene sequences. The complete genome of the detected EV-118 consists of 7,360 nucleotides, excluding the poly (A) tail. The 5'UTR contains 669 nucleotides, and 3'UTR consists of 73 nucleotides. A single open reading frame from base 670 to 7,287 that encodes a 2,206-amino-acid polyprotein was featured. The base composition of the full genome is 27.9 % A, 24.2 % C, 24.4 % G, and 23.6 % U. Phylogenetic analysis of the full genome sequences illustrated EV-118 was genetically closer to EV-109 and EV-105, and the Chinese strain differed from Peru strain. In summary, the presence of EV-118 was confirmed in pediatric pneumonia cases and complete genome sequences were identified for the first time in China.
authors.affiliation: School of Public Health, Peking University, Beijing, 100191, People's Republic of China.
authors.forename: Qing-Bin
authors.initials: QB
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wo
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Wang
authors.forename: Xiao-Ai
authors.initials: XA
authors.lastname: Zhang
authors.forename: Dou-Dou
authors.initials: DD
authors.lastname: Huang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhao
authors.forename: En-Mei
authors.initials: EM
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Wu-Chun
authors.initials: WC
authors.lastname: Cao
mesh_terms: D000208:Acute Disease; D001483:Base Sequence; D002681:China; D004770:Enterovirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification*; D004769:Enterovirus Infections / Q000821:virology*; D016679:Genome, Viral; D006801:Humans; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010802:Phylogeny; D012140:Respiratory Tract Diseases / Q000821:virology*; D014764:Viral Proteins / Q000235:genetics
chemical_list: D014764:Viral Proteins