title: No evidence that runs of homozygosity are associated with schizophrenia in an Irish genome-wide association dataset.
abstract: Runs of homozygosity (ROH), regions of the genome containing many consecutive homozygous SNPs, may represent two copies of a haplotype inherited from a common ancestor. A rare variant on this haplotype could thus be present in a homozygous and potentially recessive state. To detect rare risk variants for schizophrenia, we performed an ROH analysis in a homogeneous Irish genome wide association study (GWAS) dataset consisting of 1606 cases and 1794 controls. There was no genome-wide excess of ROH in cases compared to controls (p=0.7986). No consensus ROH at individual loci showed association with schizophrenia after genome-wide correction.
authors.affiliation: Department of Psychiatry & Neuropsychiatric Genetics Research Group, School of Medicine, The Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland. Electronic address: eaheron@tcd.ie.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Heron
authors.affiliation: Department of Psychiatry & Neuropsychiatric Genetics Research Group, School of Medicine, The Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland. Electronic address: cormicp@tcd.ie.
authors.forename: Paul
authors.initials: P
authors.lastname: Cormican
authors.affiliation: Department of Psychiatry & Neuropsychiatric Genetics Research Group, School of Medicine, The Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland. Electronic address: donoghug@tcd.ie.
authors.forename: Gary
authors.initials: G
authors.lastname: Donohoe
authors.affiliation: Department of Psychiatry, Queen's University, Belfast, BT7 1NN, Northern Ireland, United Kingdom. Electronic address: tony.oneill@qub.ac.uk.
authors.forename: Francis A
authors.initials: FA
authors.lastname: O'Neill
authors.affiliation: Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States; Department of Human Genetics, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States. Electronic address: kendler@hsc.vcu.edu.
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Kendler
authors.affiliation: Department of Psychiatry, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States; Department of Human Genetics, Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States. Electronic address: bpriley@vcu.edu.
authors.forename: Brien P
authors.initials: BP
authors.lastname: Riley
authors.affiliation: Department of Psychiatry & Neuropsychiatric Genetics Research Group, School of Medicine, The Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland. Electronic address: mgill@mail.tcd.ie.
authors.forename: Michael
authors.initials: M
authors.lastname: Gill
authors.affiliation: Department of Psychiatry & Neuropsychiatric Genetics Research Group, School of Medicine, The Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland. Electronic address: acorvin@tcd.ie.
authors.forename: Aiden P
authors.initials: AP
authors.lastname: Corvin
authors.affiliation: Department of Psychiatry & Neuropsychiatric Genetics Research Group, School of Medicine, The Trinity Centre for Health Sciences, St. James's Hospital, Dublin 8, Ireland. Electronic address: morrisdw@tcd.ie.
authors.forename: Derek W
authors.initials: DW
authors.lastname: Morris
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D007494:Ireland; D016015:Logistic Models; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
keywords: GWAS; Mutation; Rare variant; Runs of homozygosity; Schizophrenia