title: Reversible conduction failure in overlap of Miller Fisher syndrome and pharyngeal-cervical-brachial variant of Guillain-Barré syndrome in the spectrum of nodo-paranodopathies.
abstract: Patients with an overlap of the pharyngeal-cervical-brachial variant of Guillain-Barré syndrome and Miller Fisher syndrome (PCB/MFS) have rarely been reported. The electrophysiological findings in PCB/MFS are of great interest and may provide insight into the pathophysiology of the disorder. We report the clinical features and nerve conduction study findings in a patient with PCB/MFS with high titers of antiganglioside antibodies against GQ1b, GD1a, and GD1b. In serial nerve conduction studies, compound muscle action potential amplitudes normalised without development of temporal dispersion within 3 weeks, and absent median, ulnar, and sural sensory nerve action potentials became recordable within 4 months. These findings are consistent with reversible conduction failure in both motor and sensory fibres, and PCB/MFS could be classified in the recently described nodo-paranodopathy spectrum of acute neuropathies associated with anti-ganglioside antibodies.
authors.affiliation: Bezmi Alem Vakıf University, Medical Faculty, Department of Neurology, Adnan Menderes Bulvarı, 34093 Fatih, Istanbul, Turkey. Electronic address: aesragursoy@gmail.com.
authors.forename: Azize Esra
authors.initials: AE
authors.lastname: Gürsoy
authors.affiliation: Bezmi Alem Vakıf University, Medical Faculty, Department of Neurology, Adnan Menderes Bulvarı, 34093 Fatih, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kolukısa
authors.affiliation: Bezmi Alem Vakıf University, Medical Faculty, Department of Neurology, Adnan Menderes Bulvarı, 34093 Fatih, Istanbul, Turkey.
authors.forename: Gülsen
authors.initials: G
authors.lastname: Babacan-Yıldız
authors.affiliation: Bezmi Alem Vakıf University, Medical Faculty, Department of Neurology, Adnan Menderes Bulvarı, 34093 Fatih, Istanbul, Turkey.
authors.forename: Özge
authors.initials: Ö
authors.lastname: Altıntaş
authors.affiliation: Bezmi Alem Vakıf University, Medical Faculty, Department of Neurology, Adnan Menderes Bulvarı, 34093 Fatih, Istanbul, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Yaman
authors.affiliation: Bezmi Alem Vakıf University, Medical Faculty, Department of Neurology, Adnan Menderes Bulvarı, 34093 Fatih, Istanbul, Turkey.
authors.forename: Talip
authors.initials: T
authors.lastname: Asil
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000369:Aged, 80 and over; D001917:Brachial Plexus / Q000503:physiopathology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000503:physiopathology*; D006801:Humans; D019846:Miller Fisher Syndrome / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology*; D010609:Pharyngeal Muscles / Q000503:physiopathology
keywords: Guillain-Barré syndrome; Miller Fisher syndrome; Pharyngeal–cervical–brachial weakness; Reversible conduction failure