title: VPS35 Parkinson's disease phenotype resembles the sporadic disease.
abstract: Recently a new autosomal dominant Parkinson's disease mutation (p.Asp620Asn) in the VPS35 gene was discovered. The clinical features of 14 PD patients with this mutation from three Austrian families were evaluated. Age at disease-onset appears lower and depression was more common in Austrian patients compared to sporadic PD patients. However, we were unable to identify a specific clinical maker of VPS35 patients, who otherwise resemble sporadic PD patients.
authors.affiliation: Department of Neurology, Allgemeines Krankenhaus Linz (AKHL), Krankenhausstr. 9, 4020, Linz, Upper Austria, Austria, walter.struhal@akh.linz.at.
authors.forename: Walter
authors.initials: W
authors.lastname: Struhal
authors.forename: Stefan
authors.initials: S
authors.lastname: Presslauer
authors.forename: Sabine
authors.initials: S
authors.lastname: Spielberger
authors.forename: Alexander
authors.initials: A
authors.lastname: Zimprich
authors.forename: Eduard
authors.initials: E
authors.lastname: Auff
authors.forename: Thomas
authors.initials: T
authors.lastname: Bruecke
authors.forename: Werner
authors.initials: W
authors.lastname: Poewe
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ransmayr
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D010641:Phenotype; D033921:Vesicular Transport Proteins / Q000235:genetics*
chemical_list: C419573:VPS35 protein, human; D033921:Vesicular Transport Proteins