title: Practical approach for asymmetric hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds: application to one-pot synthesis of chiral allylamines.
abstract: The highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from a hydroxamic acid derivative was realized by simple and readily available chiral amine catalysts. The resulting hydroxyamination products were readily converted to the corresponding chiral 1,2-aminoalcohol or allylamine derivatives in one pot.
authors.affiliation: Department of Chemistry, Graduate School of Science, Kyoto University , Sakyo, Kyoto 606-8502, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Kano
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Shirozu
authors.forename: Keiji
authors.initials: K
authors.lastname: Maruoka
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000499:Allylamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D009603:Nitroso Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000588:Amines; D007659:Ketones; D009603:Nitroso Compounds; D000499:Allylamine