title: Exposure to sublethal concentrations of copper changes biochemistry parameters in silver catfish, Rhamdia quelen, Quoy & Gaimard.
abstract: The effects of Cu exposure on catalase (CAT) and acetylcholinesterase (AChE) activity, formation of thiobarbituric acid-reactive species (TBARS) and metabolic parameters were evaluated in silver catfish (Rhamdia quelen). The fish were exposed for 45 days to 0, 16 and 29 μg/L Cu. The fish that were exposed to Cu exhibited lower TBARS levels in the muscle and higher TBARS levels in the liver. They also showed lower CAT activity in the liver and lower AChE activity in the brain and muscle. Higher glucose and lactate and lower protein plasma levels were observed in the fish exposed to Cu. The changes in the hepatic metabolic parameters were Cu concentration dependent. In the muscle, lower glycogen and higher lactate levels were observed in the fish exposed to Cu. Alterations in the metabolic parameters showed a preference for the anaerobic pathway of energy production and liver protein catabolism to supply the energy demand.
authors.affiliation: Laboratório de Bioquímica Adaptativa, Departamento de Química - Programa de Pós graduação em Biodiversidade Animal, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Pretto
authors.forename: Vania Lucia
authors.initials: VL
authors.lastname: Loro
authors.forename: Vera M Machado
authors.initials: VM
authors.lastname: Silva
authors.forename: Joseânia
authors.initials: J
authors.lastname: Salbego
authors.forename: Charlene Cavalheiro
authors.initials: CC
authors.lastname: de Menezes
authors.forename: Carine de Freitas
authors.initials: Cde F
authors.lastname: Souza
authors.forename: Carolina Rosa
authors.initials: CR
authors.lastname: Gioda
authors.forename: Bernardo
authors.initials: B
authors.lastname: Baldisserotto
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002397:Catfishes / Q000502:physiology*; D003300:Copper / Q000633:toxicity*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D017392:Thiobarbituric Acid Reactive Substances; D014874:Water Pollutants, Chemical; D003300:Copper; D002374:Catalase; D000110:Acetylcholinesterase