title: A ferrocene-pyrene based 'turn-on' chemodosimeter for Cr(3+)- application in bioimaging.
abstract: Structurally simple, ferrocene-pyrene imine dyad 1 has been developed as a 'turn-on' chemodosimeter for Cr(3+). The sensing event is based upon the hydrolysis of the imine functionality. Further, 1, which is also non-cytotoxic (100% cell viability), detects intracellular Cr(3+) in the human breast cancer (MCF-7) cells.
authors.affiliation: Department of Chemistry, UGC-Center for Advanced Studies-I, Guru Nanak Dev University, Amritsar-143 005, Punjab, India. paramjit19in@yahoo.co.in kamaljit19in@yahoo.co.in.
authors.forename: Mandeep
authors.initials: M
authors.lastname: Kaur
authors.forename: Paramjit
authors.initials: P
authors.lastname: Kaur
authors.forename: Vikram
authors.initials: V
authors.lastname: Dhuna
authors.forename: Sukhdev
authors.initials: S
authors.lastname: Singh
authors.forename: Kamaljit
authors.initials: K
authors.lastname: Singh
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002857:Chromium / Q000032:analysis*; D005260:Female; D006801:Humans; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D018613:Microscopy, Confocal; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011721:Pyrenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D007097:Imines; D009942:Organometallic Compounds; D011721:Pyrenes; D002857:Chromium