title: Host-guest inclusion system of scutellarein with 2-hydroxypropyl-beta-cyclodextrin: preparation, characterization, and anticancer activity.
abstract: The inclusion complexation behavior of scutellarein (SCUE) with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) has been investigated in both solution and in the solid state. SCUE/HP-β-CD solid system was prepared by suspension method. The formation of SCUE/HP-β-CD complex in aqueous solution was demonstrated by fluorescence spectroscopy, and the Job plot showed a maximum at a molar fraction of 0.5, indicating 1:1 inclusion complexation between SCUE and HP-β-CD. However, SCUE/HP-β-CD inclusion complex was characterized by means of XRD, DSC, (1)H, and two-dimensional NMR. Through the complexation between HP-β-CD and SCUE, the water solubility and antitumor activity of SCUE were obviously increased. This satisfactory water solubility and high antitumor activity of the SCUE/HP-β-CD complex will be potentially useful for its application on human colon cancer chemotherapies.
authors.affiliation: a Faculty of Life Science and Technology , Kunming University of Science and Technology , Kunming 650500 , P.R. China.
authors.forename: Fen
authors.initials: F
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Yulin
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiali
authors.initials: X
authors.lastname: Liao
authors.forename: Chuanzhu
authors.initials: C
authors.lastname: Gao
authors.forename: Ruijian
authors.initials: R
authors.lastname: Jiang
authors.forename: Bin
authors.initials: B
authors.lastname: Han
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Man
authors.initials: M
authors.lastname: Liu
authors.forename: Rongguang
authors.initials: R
authors.lastname: Zhou
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D047310:Apigenin / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D045325:HCT116 Cells; D019073:HT29 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D047310:Apigenin; C458179:scutellarein