title: Structural characterization and antioxidative activity of lancifonins: unique nortriterpenoids from Schisandra lancifolia.
abstract: Six unique nortriterpenoids, lancifonins A-F (1-6), were isolated from Schisandra lancifolia. Their absolute configurations were determined by X-ray diffraction and ECD calculation. The conformational analysis of 1 was performed due to the unanticipated changes of Cotton effects in its ECD spectrum. Compounds 5 and 6 possess a unique 7/7 fused carbocyclic core with an internal ester bridge between C-9 and C-14, and 5 exhibited protective activity against H2O2-induced oxidative damage on Caco-2 cells.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, Yunnan, P. R. China.
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shi
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Shan-Zhai
authors.initials: SZ
authors.lastname: Shang
authors.forename: Peng
authors.initials: P
authors.lastname: Cao
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018938:Caco-2 Cells; D018360:Crystallography, X-Ray; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008968:Molecular Conformation; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D000975:Antioxidants; D014315:Triterpenes; C000588716:lancifonin A; C000588717:lancifonin E; D006861:Hydrogen Peroxide