title: Intrahepatic cholangiocarcinoma.
abstract: Intrahepatic cholangiocarcinoma (ICC) is a rare tumor, with an increasing incidence worldwide and an overall poor prognosis. Symptoms are usually nonspecific, contributing to an advanced tumor stage at diagnosis. The staging system for ICC has recently been updated and is based on number of lesions, vascular invasion, and lymph node involvement. Complete surgical resection to negative margins remains the only potentially curable treatment for ICC. Gemcitabine-based adjuvant therapy can be offered based on limited data from patients with unresectable ICC. Overall 5-year survivals after resection range from 17% to 44%, with median survivals of 19 to 43 months.
authors.affiliation: Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0541, USA. Electronic address: km3brown@utmb.edu.
authors.forename: Kimberly M
authors.initials: KM
authors.lastname: Brown
authors.affiliation: Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0541, USA; Department of Surgery, University of California San Francisco-East Bay, 1411 East 31st Street, Oakland, CA 94602, USA.
authors.forename: Abhishek D
authors.initials: AD
authors.lastname: Parmar
authors.affiliation: Liver Cancer Center, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, Pittsburgh, PA 15213-2582, USA. Electronic address: gellerda@upmc.edu.
authors.forename: David A
authors.initials: DA
authors.lastname: Geller
mesh_terms: D001650:Bile Duct Neoplasms; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma; D006801:Humans
keywords: Bile duct neoplasms; Cholangiocarcinoma; Intrahepatic bile duct cancer; Intrahepatic cholangiocarcinoma; Peripheral cholangiocarcinoma