title: Modulation of chromatin modifying complexes by noncoding RNAs in trans.
abstract: Increasing evidence supports a central role for ncRNA in numerous aspects of chromatin function. For instance, ncRNAs can act as a scaffold for the recruitment of certain chromatin modifying complexes to specific sites within the genome. It is easily imaginable how this can occur in cis, but examples also exist whereby targeting of complexes by ncRNA occurs in trans to the site of transcription. Moreover, association of an ncRNA with a particular locus can trigger localization of the gene to a subnuclear structure harboring a specialized transcriptional environment. In this review, we discuss new insights into the mechanisms by which ncRNAs function in trans with respect to Polycomb Group, chromatin insulator, and dosage compensation complexes in mammals and/or Drosophila.
authors.affiliation: Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Názer
authors.affiliation: Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: leielissa@niddk.nih.gov.
authors.forename: Elissa P
authors.initials: EP
authors.lastname: Lei
mesh_terms: D000818:Animals; D000076246:CCCTC-Binding Factor; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D053487:DEAD-box RNA Helicases / Q000378:metabolism; D018628:Gene Dosage; D006801:Humans; D022661:RNA, Untranslated / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D000076246:CCCTC-Binding Factor; C000619697:CTCF protein, human; D002843:Chromatin; D022661:RNA, Untranslated; D012097:Repressor Proteins; D053487:DEAD-box RNA Helicases