title: Association of aromatase inhibitors with coronary heart disease in women with early breast cancer.
abstract: As compared to tamoxifen aromatase inhibitors (AIs) may increase the risk of heart disease. Here we explored the association between the use of AIs and coronary artery disease (CAD) in a population-based observational study. In a small and heterogeneous population of 74 women with early breast cancer who received adjuvant hormonal therapy and subsequently underwent cardiac angiography, AIs significantly increased the hazard for CAD (HR 3.23, 95% confidence intervals [CI] 1.26-8.25, p = .01) compared to tamoxifen. Our results suggest that therapy with AIs may increase the risk for CAD.
authors.affiliation: Sector of Medical Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia.
authors.forename: B
authors.initials: B
authors.lastname: Seruga
authors.forename: V
authors.initials: V
authors.lastname: Zadnik
authors.forename: C Grasic
authors.initials: CG
authors.lastname: Kuhar
authors.forename: T
authors.initials: T
authors.lastname: Marinko
authors.forename: T
authors.initials: T
authors.lastname: Cufer
authors.forename: B
authors.initials: B
authors.lastname: Zakotnik
authors.forename: D
authors.initials: D
authors.lastname: Zorman
authors.forename: A
authors.initials: A
authors.lastname: Ocana
authors.forename: E
authors.initials: E
authors.lastname: Amir
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D047072:Aromatase Inhibitors / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D016016:Proportional Hazards Models; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013629:Tamoxifen / Q000009:adverse effects; D013997:Time Factors
chemical_list: D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D013629:Tamoxifen