title: Massive haemoptysis following dabigatran administration in a patient with bronchiectasis.
abstract: We report a case of life-threatening haemoptysis after administration of dabigatran in a patient with bronchiectasis. A 72-year-old woman had received dabigatran at a dose of 110 mg twice daily for chronic atrial fibrillation. She was admitted to our hospital for cerebral infarction after a few days of self-interruption of dabigatran. After the diagnosis of cerebral infarction, administration of dabigatran was restarted. Seven days later, she suffered acute-onset massive haemoptysis and required mechanical ventilation. Dabigatran treatment was discontinued, and bronchial artery embolisation (BAE) was performed twice. The bleeding continued for 11 days, but she recovered and was discharged on day 58 after admission.
authors.affiliation: Respiratory medicine, National Hospital Organization Kyoto Medical Center, Kyoto-shi, Kyoto, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Hayama
authors.forename: Hideki
authors.initials: H
authors.lastname: Inoue
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Wada
authors.forename: Tadashi
authors.initials: T
authors.lastname: Mio
mesh_terms: D000368:Aged; D000991:Antithrombins / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D001562:Benzimidazoles / Q000009:adverse effects*; D001981:Bronchial Arteries; D001987:Bronchiectasis / Q000150:complications; D000069604:Dabigatran; D004621:Embolization, Therapeutic; D005260:Female; D006469:Hemoptysis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy* / Q000209:etiology; D011859:Radiography; D015091:beta-Alanine / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000991:Antithrombins; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran