title: Neural activity associated with semantic versus phonological anomia treatments in aphasia.
abstract: Naming impairments in aphasia are typically targeted using semantic and/or phonologically based tasks. However, it is not known whether these treatments have different neural mechanisms. Eight participants with aphasia received twelve treatment sessions using an alternating treatment design, with fMRI scans pre- and post-treatment. Half the sessions employed Phonological Components Analysis (PCA), and half the sessions employed Semantic Feature Analysis (SFA). Pre-treatment activity in the left caudate correlated with greater immediate treatment success for items treated with SFA, whereas recruitment of the left supramarginal gyrus and right precuneus post-treatment correlated with greater immediate treatment success for items treated with PCA. The results support previous studies that have found greater treatment outcome to be associated with activity in predominantly left hemisphere regions, and suggest that different mechanisms may be engaged dependent on the type of treatment employed.
authors.affiliation: University of Queensland Centre for Clinical Research, Herston, QLD 4029, Australia; School of Health and Rehabilitation Sciences, University of Queensland, St. Lucia, QLD 4072, Australia; Centre for Advanced Imaging, University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: s.vanhees@uq.edu.au.
authors.forename: Sophia
authors.initials: S
authors.lastname: van Hees
authors.affiliation: Centre for Advanced Imaging, University of Queensland, St. Lucia, QLD 4072, Australia; Wesley Hospital, Auchenflower, QLD 4066, Australia. Electronic address: katie.mcmahon@cai.uq.edu.au.
authors.forename: Katie
authors.initials: K
authors.lastname: McMahon
authors.affiliation: School of Health and Rehabilitation Sciences, University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: a.angwin@uq.edu.au.
authors.forename: Anthony
authors.initials: A
authors.lastname: Angwin
authors.affiliation: School of Psychology, University of Queensland, St. Lucia, QLD 4072, Australia. Electronic address: greig.dezubicaray@uq.edu.au.
authors.forename: Greig
authors.initials: G
authors.lastname: de Zubicaray
authors.affiliation: University of Queensland Centre for Clinical Research, Herston, QLD 4029, Australia; School of Health and Rehabilitation Sciences, University of Queensland, St. Lucia, QLD 4072, Australia; Clinical Centre for Research Excellence in Aphasia Rehabilitation, Australia. Electronic address: d.copland@uq.edu.au.
authors.forename: David A
authors.initials: DA
authors.lastname: Copland
mesh_terms: D000328:Adult; D000368:Aged; D000849:Anomia / Q000503:physiopathology*; D001037:Aphasia / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010296:Parietal Lobe / Q000503:physiopathology*; D012660:Semantics; D016896:Treatment Outcome
keywords: Naming; Neuroimaging; Rehabilitation; Stroke; fMRI