title: Biocompatibility of wollastonite-poly(N-butyl-2-cyanoacrylate) composites.
abstract: Wollastonite-poly(n-butyl-2-cyanoacrylate) composite (W-BCA) has been proposed to immobilize anatomically bone fragments in order to achieve an optimal healing process. The present study evaluated the in vitro and in vivo behavior of three types of fillers: powdered natural wollastonite (Wn), synthetic pseudowollastonite powder (Ws), and synthetic pseudowollastonite powder coated with 5% acetyl tributyl citrate (Wst). The Wst-BCA composite underwent a higher degradability in the real-time degradation test and a superior cytotoxic effect; whereas the Wn-BCA composite showed a higher degradability in the accelerated test with no cytotoxicity. The formation of an extracellular collagenous matrix deposit on its surface and the most favorable new bone formation on Wn-BCA indicate its potential for bone adhesive use in unstable orthopedic traumas.
authors.affiliation: Divisão de Metrologia de Materiais, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Duque de Caxias, RJ, CEP 25250-020, Brazil.
authors.forename: Lídia Ágata
authors.initials: LÁ
authors.lastname: de Sena
authors.forename: Marcelo Sanmartin
authors.initials: MS
authors.lastname: de Almeida
authors.forename: Gustavo V
authors.initials: GV
authors.lastname: de Oliveira Fernandes
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Guerra Bretaña
authors.forename: Igor Iuco
authors.initials: II
authors.lastname: Castro-Silva
authors.forename: José Mauro
authors.initials: JM
authors.lastname: Granjeiro
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Achete
mesh_terms: D000180:Acrylic Resins / Q000138:chemical synthesis / Q000737:chemistry*; D000818:Animals; D001843:Bone Cements / Q000138:chemical synthesis / Q000737:chemistry*; D017610:Calcium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002460:Cell Line; D003487:Cyanoacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D017640:Silicates / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000180:Acrylic Resins; D001843:Bone Cements; D017610:Calcium Compounds; D003487:Cyanoacrylates; D017640:Silicates; C031293:calcium silicate
keywords: butylcyanoacrylate; composite; cytotoxicity; implantation; wollastonite