title: Does DcR1 (TNF-related apoptosis-inducing-ligand Receptor 3) have any role in human AMD pathogenesis?
abstract: It has been postulated that there is a link between age related degenerative diseases and cancer. The TNF-related apoptosis-inducing ligand (TRAIL) has been shown to selectively kill tumor cells by binding to pro-apoptotic and anti-apoptotic receptors. Our aim was to study the levels of anti-apoptotic receptor (DcR1) in age related macular degeneration (AMD) and controls. AMD patients (115) were classified into two groups: Dry and Wet AMD. Wet AMDs were further classified into occult, predominant classic and minimal classic. 61 healthy individuals were recruited as normal controls. After normalization with total protein, DcR1 levels were analyzed by ELISA. Mann Whitney U-statistic was used for analysis of DcR1 ELISA results. We have observed DcR1 levels in serum sample which were significantly lower in AMD patients as compared to controls (p = 0.001). On the other hand, we did not find difference in DcR1 levels between wet and dry AMD. The present study defines the plausible role of DcR1 in AMD pathology signifying a new therapeutic target for AMD.
authors.affiliation: 1] Neuroscience Researh Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India [2].
authors.forename: Akshay
authors.initials: A
authors.lastname: Anand
authors.affiliation: 1] Neuroscience Researh Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India [2].
authors.forename: Neel K
authors.initials: NK
authors.lastname: Sharma
authors.affiliation: 1] Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India [2].
authors.forename: Ramandeep
authors.initials: R
authors.lastname: Singh
authors.affiliation: Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Amod
authors.initials: A
authors.lastname: Gupta
authors.affiliation: Neuroscience Researh Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Sudesh
authors.initials: S
authors.lastname: Prabhakar
authors.affiliation: Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Neeru
authors.initials: N
authors.lastname: Jindal
authors.affiliation: Department of Biotechnology, Himachal Pradesh University, Shimla, India.
authors.forename: Arvind K
authors.initials: AK
authors.lastname: Bhatt
authors.affiliation: Department of Statistics, Panjab University, Chandigarh, India.
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Sharma
authors.affiliation: Neuroscience Researh Lab, Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
authors.forename: Pawan K
authors.initials: PK
authors.lastname: Gupta
mesh_terms: D017209:Apoptosis / Q000502:physiology; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood / Q000378:metabolism; D006801:Humans; D008268:Macular Degeneration / Q000097:blood* / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D053320:Receptors, Tumor Necrosis Factor, Member 10c; D053319:Tumor Necrosis Factor Decoy Receptors / Q000097:blood / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D058851:GPI-Linked Proteins; D053320:Receptors, Tumor Necrosis Factor, Member 10c; C108661:TNFRSF10C protein, human; D053319:Tumor Necrosis Factor Decoy Receptors