title: [Expression and significance of tumor necrosis factor receptor associated protein 1 in epithelial ovarian cancer].
abstract: OBJECTIVE
  To explore the levels of TRAP1 and its roles in patients with ovarian tumor, and investigate the correlation between the expressions of TRAP1 in ovarian tumor tissues and related clinicopathological characteristics.
  
  
  METHODS
  38 health women, 50 cases of benign ovarian tumors and 114 cases of epithelial ovarian cancers were examined by real-time RT-PCR and immunohistochemical staining.
  
  
  RESULTS
  The immunohistochemical analysis demonstrated that TRAP1 protein was mainly located in the cytoplasm, the protein and mRNA expression of TRAP1 in ovarian cancer were significantly increased compared with those of normal control and benign tumor (P < 0.05). The protein and mRNA expression of TRAP1 was related to histological grade and pathologic types (P < 0.05), but not age, clinical stages, lymphnode metastasis or omental metastasis, and the amount of ascites (P > 0.05).
  
  
  CONCLUSIONS
  The high expression of TRAP1 may play potential role in epithelial ovarian cancer occurrence and progress.
authors.affiliation: Gynecologic Oncology Center, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Rui-qiong
authors.initials: RQ
authors.lastname: Ma
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Cheng
authors.forename: Xue
authors.initials: X
authors.lastname: Ye
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Heng
authors.initials: H
authors.lastname: Cui
authors.forename: Li-hui
authors.initials: LH
authors.lastname: Wei
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Chang
mesh_terms: D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism*
chemical_list: D018841:HSP90 Heat-Shock Proteins; C092306:TRAP1 protein, human