title: [Evolution of the use of antidepressants, anxiolytics and hypnotics in Valencia. Period 2000-2010].
abstract: OBJECTIVE
  To describe the evolution in the use of antidepressants (AD), anxiolytics (A) and hypnotics (H) in the Comunitat Valenciana (CV) between 2000 and 2010, their expenditure, and the cost of the defined daily dose (DDD).
  
  
  METHODS
  Retrospective observational study.
  
  
  METHODS
  Prescriptions covered by the health public service of the CV during the period 2000-2010.
  
  
  METHODS
  Consumption of the therapeutic groups N06A (antidepressants), N05B (anxiolytics) and N05C (hypnotics) from the pharmacy database of the public Valencian Health Agency measured in defined daily dose per 1.000 inhabitants.
  
  
  RESULTS
  During the period of study the use of AD increased by 81.2% and A and H, 11.7%. Selective serotonin reuptake inhibitors were the most prescribed AD and Selective serotonin and norepinephrine reuptake inhibitors experienced the higher rise (386.8%). The increase of escitalopram was 1.013%. Lorazepam, alprazolam and diazepam, accounted for the 80.4% of the anxyolitics, and lormetazepam and zolpidem the 88.7% of the hypnotics. The expenditure rise of AD was by 78.2% and that of the A and H was 14.5%; the cost of the DDD of both decreased by 29%.
  
  
  CONCLUSIONS
  Antidepressant utilization has experienced a remarkable rise between 2000 and 2010 while that of A and H has been mild even though they are still more consumed than AD. In spite of the reduction of the DDD cost in both therapeutic groups, the whole expenditure on AD in the CV is still growing.
authors.affiliation: Médico de familia, Centro de Salud de Paterna, Paterna, Valencia, España. Electronic address: meresempere@gmail.com.
authors.forename: Ermengol
authors.initials: E
authors.lastname: Sempere Verdú
authors.affiliation: Psiquiatra, Centro de Salud de Paterna, Paterna, Valencia, España.
authors.forename: José
authors.initials: J
authors.lastname: Salazar Fraile
authors.affiliation: Médico de familia, Subdirección Asistencial Departamento de Salud de la Ribera, Alzira, Valencia, España.
authors.forename: Vicente
authors.initials: V
authors.lastname: Palop Larrea
authors.affiliation: Médico de familia, Centro de Salud Son Vileta, Palma de Mallorca, Islas Baleares, España.
authors.forename: Caterina
authors.initials: C
authors.lastname: Vicens Caldentey
mesh_terms: D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D004363:Drug Utilization / Q000706:statistics & numerical data* / Q000639:trends*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D012189:Retrospective Studies; D013030:Spain; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D006993:Hypnotics and Sedatives
keywords: Ansiolíticos; Antidepresivos; Antidepressants; Anxiolytics; Drug utilization; Gasto farmacéutico; Hipnóticos; Hypnotics; Pharmacoeconomics; Utilización de medicamentos
vernacular_title: Evolución de la utilización de antidepresivos, ansiolíticos e hipnóticos en la Comunitat Valenciana. Período 2000-2010.