title: Classics in chemical neuroscience: diazepam (valium).
abstract: Diazepam (Valium) is among the most successful drugs from the onset of the psychopharmacological revolution that began during the 1950s. Efficacious in treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set the standard for pharmacotherapy in terms of potency, onset of action, and safety. In this Review, the legacy of diazepam to chemical neuroscience will be considered along with its synthesis, pharmacology, drug metabolism, adverse events and dependence, clinical use, and regulatory issues.
authors.affiliation: Department of Pharmacology, Johns Hopkins University , Baltimore, Maryland 21205, United States.
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Calcaterra
authors.forename: James C
authors.initials: JC
authors.lastname: Barrow
mesh_terms: D001008:Anxiety Disorders / Q000188:drug therapy*; D003975:Diazepam / Q000008:administration & dosage* / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D062787:Drug Overdose / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D012120:Respiration Disorders / Q000139:chemically induced* / Q000517:prevention & control; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D003975:Diazepam