title: Extracorporeal blood purification in burns: a review.
abstract: A prolonged and fulminant inflammatory state, with high levels of pro- and anti-inflammatory mediators, is seen after extensive thermal injury. Blood purification techniques including plasma exchange, continuous venovenous hemofiltration, and adsorbing membranes have the potential to modulate this response, thereby improving outcomes. This article describes the scientific rationale behind blood purification in burns and offers a review of literature regarding its potential application in this patient cohort.
authors.affiliation: U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States. Electronic address: Katharina.Linden@ukb.uni-bonn.de.
authors.forename: Katharina
authors.initials: K
authors.lastname: Linden
authors.affiliation: San Antonio Military Medical Center, Fort Sam Houston, San Antonio, TX 78234, United States.
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Stewart
authors.affiliation: U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States.
authors.forename: Stefan F X
authors.initials: SF
authors.lastname: Kreyer
authors.affiliation: U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States.
authors.forename: Vittorio
authors.initials: V
authors.lastname: Scaravilli
authors.affiliation: San Antonio Military Medical Center, Fort Sam Houston, San Antonio, TX 78234, United States; Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, United States.
authors.forename: Jeremy W
authors.initials: JW
authors.lastname: Cannon
authors.affiliation: U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States; University of Texas Health Science Center, San Antonio, TX 78229, United States.
authors.forename: Leopoldo C
authors.initials: LC
authors.lastname: Cancio
authors.affiliation: U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States.
authors.forename: Andriy I
authors.initials: AI
authors.lastname: Batchinsky
authors.affiliation: U.S. Army Institute of Surgical Research, Fort Sam Houston, San Antonio, TX 78234, United States; Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, United States.
authors.forename: Kevin K
authors.initials: KK
authors.lastname: Chung
mesh_terms: D001781:Blood Component Removal / Q000379:methods*; D002056:Burns / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D016207:Cytokines / Q000097:blood; D006440:Hemofiltration / Q000379:methods*; D006801:Humans
chemical_list: D016207:Cytokines
keywords: Blood purification; Burns; Cytokine removal; Thermal injury