title: Value of endorectal magnetic resonance imaging at 3T for the local staging of prostate cancer.
abstract: OBJECTIVE
  To assess the accuracy of endorectal 3 T magnetic resonance imaging (MRI) in detecting extracapsular extension (ECE) and seminal vesicle invasion (SVI) of prostate cancer (PCa).
  
  
  METHODS
  38 consecutive patients with biopsy-proven PCa underwent multiparametric endorectal MRI at 3 T prior to prostatectomy. Two readers (A with nine years of experience and B with four) used established criteria for ECE and SVI to diagnose the extent of local disease in six regions (apical, dorsolateral, basal; left and right each) with the highest chance of ECE. The standard of reference was provided by intraoperative frozen section analysis and prostatectomy specimens.
  
  
  RESULTS
  Histopathology revealed ECE in 15 of the 222 regions (10 of 37 patients) and SVI in 8 of 74 potential regions (5 of 37 patients). The sensitivity, specificity, and accuracy in detecting ECE for reader A/B were 93%/67%, 92%/95% and 92%/93% per region and 90%/80%, 74%/82% and 78%/81% per patient, respectively. The corresponding values for the detection of SVI were 80%/100%, 96%/99% and 95%/97%, respectively.
  
  
  CONCLUSIONS
  Endorectal 3 T MRI is a highly reliable noninvasive technique for the local staging of PCa.
  
  
  CONCLUSIONS
  ► Endorectal 3 T MRI provided high accuracy for the local staging of prostate cancer. ► The sensitivity in detecting extracapsular tumor growth per patient was 80% or higher. ► The specificity in detecting extracapsular extension (pT3 stage) was good.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital.
authors.forename: J
authors.initials: J
authors.lastname: Otto
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital.
authors.forename: G
authors.initials: G
authors.lastname: Thörmer
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Seiwerts
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital.
authors.forename: J
authors.initials: J
authors.lastname: Fuchs
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital.
authors.forename: N
authors.initials: N
authors.lastname: Garnov
authors.affiliation: Department of Urology, Leipzig University Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Franz
authors.affiliation: Institute of Pathology, University of Leipzig.
authors.forename: L-C
authors.initials: LC
authors.lastname: Horn
authors.affiliation: Department of Urology, Leipzig University Hospital.
authors.forename: M H
authors.initials: MH
authors.lastname: Do
authors.affiliation: Department of Urology, Leipzig University Hospital.
authors.forename: J-U
authors.initials: JU
authors.lastname: Stolzenburg
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Kahn
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Moche
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig University Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Busse
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies