title: Association of liver X receptor α (LXRα) gene polymorphism and coronary heart disease, serum lipids and glucose levels.
abstract: BACKGROUND
  To explore the relationship between the liver X receptor α gene (LXRα) rsl2221497 polymorphism and the susceptibility of coronary heart disease (CHD) and serum lipids and glucose levels.
  
  
  METHODS
  The single fluorescently labeled probes technique was used to detect the genotype of rsl2221497 in LXRα gene in 240 CHD patients and 250 healthy control subjects. The difference of genotype distribution between the two groups was analyzed using of Chi-square test. The serum lipids and glucose levels between the different genotypes were also compared.
  
  
  RESULTS
  The risk of CHD in carriers with (AA + GA) genotype was 1.76 times as that in the GG genotype carriers (OR = 1.76, 95% CI: 1.18-2.87, P <0.05), and the risk of CHD in carriers with A allele increased 0.88 times compared to that in G allele carriers (OR = 1.88, 95% CI:1.21-3.43, P <0.01). Logistic regression analysis showed that after adjusting for other confounding factors, A allele was an independent risk for CHD. However, there were no differences in serum lipids and glucose levels between each genotype.
  
  
  CONCLUSIONS
  The rsl2221497 polymorphism in LXRα gene was associated with susceptibility of CHD in Han population.
authors.forename: Yun-Fei
authors.initials: YF
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Zong-Xue
authors.initials: ZX
authors.lastname: Li
authors.forename: Jing-Li
authors.initials: JL
authors.lastname: Miao
authors.forename: Qiao-Xiang
authors.initials: QX
authors.lastname: Yin
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Li
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Li
authors.affiliation: The cadre ward of General Hospital of the Air Force PLA, No, 30, Fucheng Road, Haidian District, Beijing 100142, China. luohuilan998@163.com.
authors.forename: Hui-Lan
authors.initials: HL
authors.lastname: Luo
mesh_terms: D000368:Aged; D001786:Blood Glucose; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008055:Lipids / Q000097:blood*; D000071518:Liver X Receptors; D008297:Male; D008875:Middle Aged; D057093:Orphan Nuclear Receptors / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; D008055:Lipids; D000071518:Liver X Receptors; C000605213:NR1H3 protein, human; D057093:Orphan Nuclear Receptors