title: Lymphoepithelioma-like carcinoma and simultaneous marginal zone lymphoma of the skin: a case report.
abstract: Lymphoepithelioma-like carcinoma (LELC) of the skin is a rare malignant epithelial neoplasm, which shows histological resemblance of nasopharyngeal carcinoma (Schmincke-Regaud tumor). Similar tumors have been reported at a variety of sites, including salivary gland, tonsil, thymus, stomach, and uterus. Extracutaneous LELC shows frequently an association with Epstein-Barr virus, whereas Epstein-Barr virus in LELC of the skin has been described only once till now. LELC of the skin usually presents as a papulonodular lesion on the head or neck of patients above 50 years of age. Here, we describe a collision tumor with an LELC and a marginal zone lymphoma of the skin in a 75-year-old female patient. To our knowledge, this is the first reported case of an association between these 2 malignancies, and the possibility of a causal relationship is discussed.
authors.affiliation: *Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig-Holstein, Luebeck, Germany; and †Department of Dermatology, Klinikum Hildesheim, Hildesheim, Germany.
authors.forename: Niklas
authors.initials: N
authors.lastname: Gebauer
authors.forename: Hartmut
authors.initials: H
authors.lastname: Merz
authors.forename: Karl W
authors.initials: KW
authors.lastname: Ottmann
authors.forename: Michael
authors.initials: M
authors.lastname: Tronnier
mesh_terms: D000368:Aged; D002610:Cheek / Q000473:pathology; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*