title: Building shared experience to advance practical application of pathway-based toxicology: liver toxicity mode-of-action.
abstract: A workshop sponsored by the Human Toxicology Project Consortium (HTPC), "Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action" brought together experts from a wide range of perspectives to inform the process of pathway development and to advance two prototype pathways initially developed by the European Commission Joint Research Center (JRC): liver-specific fibrosis and steatosis. The first half of the workshop focused on the theory and practice of pathway development; the second on liver disease and the two prototype pathways. Participants agreed pathway development is extremely useful for organizing information and found that focusing the theoretical discussion on a specific AOP is extremely helpful. In addition, it is important to include several perspectives during pathway development, including information specialists, pathologists, human health and environmental risk assessors, and chemical and product manufacturers, to ensure the biology is well captured and end use is considered.
authors.affiliation: The Humane Society of the United States.
authors.forename: Catherine
authors.initials: C
authors.lastname: Willett
authors.forename: Jessica
authors.initials: J
authors.lastname: Caverly Rae
authors.forename: Katy O
authors.initials: KO
authors.lastname: Goyak
authors.forename: Gary
authors.initials: G
authors.lastname: Minsavage
authors.forename: Carl
authors.initials: C
authors.lastname: Westmoreland
authors.forename: Melvin
authors.initials: M
authors.lastname: Andersen
authors.forename: Mark
authors.initials: M
authors.lastname: Avigan
authors.forename: Daniel
authors.initials: D
authors.lastname: Duché
authors.forename: Georgina
authors.initials: G
authors.lastname: Harris
authors.forename: Thomas
authors.initials: T
authors.lastname: Hartung
authors.forename: Hartmut
authors.initials: H
authors.lastname: Jaeschke
authors.forename: Andre
authors.initials: A
authors.lastname: Kleensang
authors.forename: Brigitte
authors.initials: B
authors.lastname: Landesmann
authors.forename: Suzanne
authors.initials: S
authors.lastname: Martos
authors.forename: Marilyn
authors.initials: M
authors.lastname: Matevia
authors.forename: Colleen
authors.initials: C
authors.lastname: Toole
authors.forename: Andrew
authors.initials: A
authors.lastname: Rowan
authors.forename: Terry
authors.initials: T
authors.lastname: Schultz
authors.forename: Jennifer
authors.initials: J
authors.lastname: Seed
authors.forename: John
authors.initials: J
authors.lastname: Senior
authors.forename: Imran
authors.initials: I
authors.lastname: Shah
authors.forename: Kalyanasundaram
authors.initials: K
authors.lastname: Subramanian
authors.forename: Mathieu
authors.initials: M
authors.lastname: Vinken
authors.forename: Paul
authors.initials: P
authors.lastname: Watkins
mesh_terms: D000826:Animal Testing Alternatives; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D064420:Drug-Related Side Effects and Adverse Reactions; D018675:Toxicity Tests / Q000379:methods*