title: Root maturation and dentin-pulp response to enamel matrix derivative in pulpotomized permanent teeth.
abstract: The success of pulpotomy of young permanent teeth depends on the proper selection of dressing materials. This study aimed to evaluate the histological and histomorphometric response of dentin-pulp complex to the enamel matrix derivative (Emdogain(®) gel) compared to that of calcium hydroxide when used as a pulp dressing in immature young permanent dogs' teeth. Dentin-like tissues bridging the full width of the coronal pulp at the interface between the injured and healthy pulp tissues were seen after 1 month in both groups. With time, the dentin bridge increased in thickness for calcium hydroxide but disintegrated and fully disappeared for Emdogain-treated group. Progressive inflammation and total pulp degeneration were only evident with Emdogain-treated group. The root apices of Emdogain-treated teeth became matured and closed by cementum that attached to new alveolar bone by a well-oriented periodontal ligament. In young permanent dentition, Emdogain could be a good candidate for periodontium but not dentino-pulpal complex regeneration.
authors.affiliation: Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Pharos University, Egypt.
authors.forename: Sherif S
authors.initials: SS
authors.lastname: Darwish
authors.affiliation: Oral Biology Department, King Abdulaziz University, Jeddah, Saudi Arabia ; Oral Biology Department, Faculty of Dentistry, Alexandria University, Egypt.
authors.forename: Shadia H
authors.initials: SH
authors.lastname: Abd El Meguid
authors.affiliation: Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Egypt.
authors.forename: Nadia A
authors.initials: NA
authors.lastname: Wahba
authors.affiliation: Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Egypt.
authors.forename: Ahmed A-R
authors.initials: AA
authors.lastname: Mohamed
authors.affiliation: The Faculty of Pharmacy, The University of Sydney, NSW 2006 Australia.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Chrzanowski
authors.affiliation: Division of Biomaterials, Conservative Dental Sciences Department, King Abdulaziz University, Jeddah, Saudi Arabia ; Biomaterials Department, Faculty of Dentistry, Tanta University, Tanta, Egypt ; UCL Eastman Dental Institute, Biomaterials and Tissue Engineering Division, 256 Gray's Inn Road, London, WC1X 8LD.
authors.forename: Ensanya A
authors.initials: EA
authors.lastname: Abou Neel
keywords: Pulpotomy; calcium hydroxide; dentin bridge and histomorphometric analysis; enamel matrix derivative