title: Alkaloids from Boophone haemanthoides (Amaryllidaceae).
abstract: In this study, the South African Amaryllid Boophone haemanthoides was examined for its phytochemical composition and cytotoxicity. In the process eight alkaloid structures, including the new compound distichaminol, were identified in bulb ethanolic extracts. Of the isolates, lycorine and distichamine exhibited strong activities against human acute lymphoblastic leukemia (CEM), breast adenocarcinoma (MCF7) and cervical adenocarcinoma (HeLa) cells with IC50S ranging from 1.8 to 9.2 microM.
authors.affiliation: Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag XO1, Scottsville 3209, South Africa.
authors.forename: Jerald J
authors.initials: JJ
authors.lastname: Nair
authors.affiliation: Centre of the Region Hand for Biotechnological and Agricultural Research, Palackjy University, Slechtitelh 11, S 78371 Olomouc, Czech Republic.
authors.forename: Lucie
authors.initials: L
authors.lastname: Rárová
authors.affiliation: Centre of the Region Hand for Biotechnological and Agricultural Research, Palackjy University, Slechtitelh 11, S 78371 Olomouc, Czech Republic.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Strnad
authors.affiliation: Departament de Productes Naturals, Facultat de Farmacia, Universitat de Barcelona, 08028, Barcelona, Spain.
authors.forename: Jaume
authors.initials: J
authors.lastname: Bastidad
authors.affiliation: Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag XO1, Scottsville 3209, South Africa.
authors.forename: Johannes
authors.initials: J
authors.lastname: van Staden
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D019668:Liliaceae / Q000737:chemistry*; D061986:MCF-7 Cells; D015394:Molecular Structure; D010617:Phenanthridines / Q000302:isolation & purification
chemical_list: D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010617:Phenanthridines; C015330:lycorine