title: Diethylcarbamazine attenuates the development of carrageenan-induced lung injury in mice.
abstract: Diethylcarbamazine (DEC) is an antifilarial drug with potent anti-inflammatory properties as a result of its interference with the metabolism of arachidonic acid. The aim of the present study was to evaluate the anti-inflammatory activity of DEC in a mouse model of acute inflammation (carrageenan-induced pleurisy). The injection of carrageenan into the pleural cavity induced the accumulation of fluid containing a large number of polymorphonuclear cells (PMNs) as well as infiltration of PMNs in lung tissues and increased production of nitrite and tumor necrosis factor-α and increased expression of interleukin-1β, cyclooxygenase (COX-2), and inducible nitric oxide synthase. Carrageenan also induced the expression of nuclear factor-κB. The oral administration of DEC (50 mg/Kg) three days prior to the carrageenan challenge led to a significant reduction in all inflammation markers. The present findings demonstrate that DEC is a potential drug for the treatment of acute lung inflammation.
authors.affiliation: Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil ; Instituto Aggeu Magalhães, FIOCRUZ, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil.
authors.forename: Edlene Lima
authors.initials: EL
authors.lastname: Ribeiro
authors.affiliation: Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Karla Patricia de Souza
authors.initials: KP
authors.lastname: Barbosa
authors.affiliation: Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Ingrid Tavares
authors.initials: IT
authors.lastname: Fragoso
authors.affiliation: Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Mariana Aragão Matos
authors.initials: MA
authors.lastname: Donato
authors.affiliation: Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Fabiana Oliveira dos Santos
authors.initials: FO
authors.lastname: Gomes
authors.affiliation: Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Bruna Santos
authors.initials: BS
authors.lastname: da Silva
authors.affiliation: Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Amanda Karolina
authors.initials: AK
authors.lastname: Soares e Silva
authors.affiliation: Pós-Graduação em Ciências Biológicas da Universidade Federal de Pernambuco, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-901 Recife, PE, Brazil.
authors.forename: Sura Wanessa Santos
authors.initials: SW
authors.lastname: Rocha
authors.affiliation: Departamento de Morfologia e Fisiologia Animal da Universidade Federal Rural de Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, 52171-900 Recife, PE, Brazil.
authors.forename: Valdemiro Amaro
authors.initials: VA
authors.lastname: da Silva Junior
authors.affiliation: Laboratório de Ultraestrutura, Instituto Aggeu Magalhães, FIOCRUZ, Avenida Professor Moraes Rego, s/n, Cidade Universitária, 50670-420 Recife, PE, Brazil.
authors.forename: Christina Alves
authors.initials: CA
authors.lastname: Peixoto
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry; D002351:Carrageenan / Q000009:adverse effects*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D004049:Diethylcarbamazine / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007249:Inflammation; D053583:Interleukin-1beta / Q000378:metabolism; D007962:Leukocytes / Q000187:drug effects; D016859:Lipoxygenase Inhibitors / Q000737:chemistry; D008168:Lung / Q000378:metabolism; D055370:Lung Injury / Q000139:chemically induced* / Q000188:drug therapy*; D008297:Male; D051379:Mice; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D010998:Pleurisy / Q000139:chemically induced; D011897:Random Allocation
chemical_list: D000893:Anti-Inflammatory Agents; D053583:Interleukin-1beta; D016859:Lipoxygenase Inhibitors; D002351:Carrageenan; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; C077623:Ptgs2 protein, mouse; D051546:Cyclooxygenase 2; D004049:Diethylcarbamazine