title: The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer.
abstract: BACKGROUND
  A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour-stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.
  
  
  METHODS
  TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.
  
  
  RESULTS
  Tumours with ≥49% stroma were associated with better survival in female (OS P=0.008, HR=0.2-0.7; RFS P=0.006, HR=0.1-0.6) and male breast cancer (OS P=0.005, HR=0.05-0.6; RFS P=0.01, HR=0.87-5.6), confirmed in multivariate analysis.
  
  
  CONCLUSIONS
  High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: C L
authors.initials: CL
authors.lastname: Downey
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Simpkins
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: J
authors.initials: J
authors.lastname: White
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: D L
authors.initials: DL
authors.lastname: Holliday
authors.affiliation: Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London, London, UK.
authors.forename: J L
authors.initials: JL
authors.lastname: Jones
authors.affiliation: Department of Pathology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
authors.forename: L B
authors.initials: LB
authors.lastname: Jordan
authors.affiliation: 2nd Department of Pathology, Semmelweis University, Üllőiút. 93, Budapest 1091, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Kulka
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: S
authors.initials: S
authors.lastname: Pollock
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: S S
authors.initials: SS
authors.lastname: Rajan
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: H H
authors.initials: HH
authors.lastname: Thygesen
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Hanby
authors.affiliation: Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds LS9 7TF, UK.
authors.forename: V
authors.initials: V
authors.lastname: Speirs
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000175:diagnosis* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism*; D017154:Stromal Cells / Q000473:pathology; D016019:Survival Analysis; D047368:Tumor Burden
chemical_list: D011960:Receptors, Estrogen