title: Mechanisms of vascular calcification and associated diseases.
abstract: Mineralization of bone and tooth extracellular matrix (ECM) is a physiologic process, while soft tissue mineralization, also known as ectopic mineralization (calcification), is a pathologic condition. Vascular calcification is common in aging and also in a number of genetic and metabolic disorders. The calcific deposits in arteries complicate the prognosis and increase the morbidity in diseases such as atherosclerosis, diabetes and chronic kidney disease (CKD). To completely understand the pathophysiology of these lifethreatening diseases, it is critical to elucidate the molecular mechanisms underlying vascular calcification. Unveiling these mechanisms will eventually identify new therapeutic targets and also improve the management of the associated complications. In the current review, we discussed the common determinants of ECM mineralization, the mechanism of vascular calcification associated with several human diseases and outlined the most common therapeutic approaches to prevent its progression.
authors.forename: Juliana
authors.initials: J
authors.lastname: Marulanda
authors.forename: Saleh
authors.initials: S
authors.lastname: Alqarni
authors.affiliation: 1529 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada. monzur.murshed@mcgill.ca.
authors.forename: Monzur
authors.initials: M
authors.lastname: Murshed
mesh_terms: D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000188:drug therapy / Q000378:metabolism*; D061205:Vascular Calcification / Q000188:drug therapy / Q000378:metabolism*