title: Temporal abstraction-based clinical phenotyping with Eureka!
abstract: Temporal abstraction, a method for specifying and detecting temporal patterns in clinical databases, is very expressive and performs well, but it is difficult for clinical investigators and data analysts to understand. Such patterns are critical in phenotyping patients using their medical records in research and quality improvement. We have previously developed the Analytic Information Warehouse (AIW), which computes such phenotypes using temporal abstraction but requires software engineers to use. We have extended the AIW's web user interface, Eureka! Clinical Analytics, to support specifying phenotypes using an alternative model that we developed with clinical stakeholders. The software converts phenotypes from this model to that of temporal abstraction prior to data processing. The model can represent all phenotypes in a quality improvement project and a growing set of phenotypes in a multi-site research study. Phenotyping that is accessible to investigators and IT personnel may enable its broader adoption.
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Post
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: Tahsin
authors.initials: T
authors.lastname: Kurc
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: Richie
authors.initials: R
authors.lastname: Willard
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: Himanshu
authors.initials: H
authors.lastname: Rathod
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: Michel
authors.initials: M
authors.lastname: Mansour
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: Akshatha Kalsanka
authors.initials: AK
authors.lastname: Pai
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: William M
authors.initials: WM
authors.lastname: Torian
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: Sanjay
authors.initials: S
authors.lastname: Agravat
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: Suzanne
authors.initials: S
authors.lastname: Sturm
authors.affiliation: Dept. of Biomedical Informatics, Emory University, Atlanta, GA.
authors.forename: Joel H
authors.initials: JH
authors.lastname: Saltz
mesh_terms: D000465:Algorithms; D057225:Data Mining / Q000379:methods; D057286:Electronic Health Records; D006801:Humans; D051188:Knowledge Bases; D010363:Pattern Recognition, Automated; D012984:Software; D013995:Time