title: [A cross-sectional survey on prevalence and risk factors for abnormal plasma liver enzymes in overweight or obese patients with type 2 diabetes mellitus].
abstract: OBJECTIVE
  To explore the prevalence and risk factors for abnormal plasma liver enzymes in patients with type 2 diabetes mellitus.
  
  
  METHODS
  Overweight or obese patients with type 2 diabetes were recruited from 60 tertiary and secondary hospitals in Guangdong Province between August 2011 and March 2012. The abnormal plasma liver enzymes was diagnosed as alanine aminotransferase >40 U/L and/or aspartate aminotransferase >40 U/L. Binary Logistic regression was used to assess the associations between abnormal plasma liver enzymes and associated risk factors.
  
  
  RESULTS
  The abnormal plasma liver enzymes were detected in 709/3543 diabetics with overweight or obesity. And the prevalence of abnormal plasma liver enzymes was 20.0%. According to binary Logistic regression analysis, the presence of abnormal plasma liver enzymes was associated with male gender (OR = 1.603, 95%CI: 1.247-2.061), higher HbA1c(OR = 1.049, 95%CI: 1.005-1.096), higher body mass index (OR = 1.058, 95%CI: 1.014-1.103), higher waist circumference (OR = 1.019, 95%CI: 1.006-1.032), higher triglyceride level (OR = 1.053, 95%CI: 1.008-1.100), adiposis hepatica (OR = 1.543; 95%CI: 1.244-1.914), regular exercises (OR = 0.591, 95%CI: 0.472-0.740) and diet control (OR = 0.794, 95%CI: 0.635-0.993).
  
  
  CONCLUSIONS
  There is a high prevalence of abnormal plasma liver enzymes in overweight/obese with diabetics. And decreasing the levels of HbA1c, body mass index, waist circumference and triglycerides, regular exercises and diet control may decrease its prevalence.
authors.affiliation: Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
authors.forename: Jiao
authors.initials: J
authors.lastname: Wang
authors.forename: Zhou-yi
authors.initials: ZY
authors.lastname: Xiong
authors.forename: Jia
authors.initials: J
authors.lastname: Sun
authors.forename: Ting
authors.initials: T
authors.lastname: Yan
authors.forename: Rong-ping
authors.initials: RP
authors.lastname: Chen
authors.forename: Ru-yi
authors.initials: RY
authors.lastname: Zhang
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Rui
authors.initials: R
authors.lastname: Yang
authors.affiliation: Email: cai_de_hong@126.com.
authors.forename: De-hong
authors.initials: DH
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000201:enzymology* / Q000453:epidemiology; D050177:Overweight / Q000201:enzymology* / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors