title: Relationship of Podoplanin and Glutathione S-transferases T1 Expression with Laryngeal Cancer.
abstract: The aim of this study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma. The study was completed with 33 patients and gene expression analysis was performed by qRT-PCR. The podoplanin and GST-T1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryngeal cancer. Of all patients, 20 had supraglottic, and the remaining 13 had glottic laryngeal cancer. Increased expression of podoplanin was found in 14 tumor tissues, but GST-T1 expression was not detected. Podoplanin expression did not show any prediction for regional metastasis, thyroid cartilage invasion, lymphatic vessel invasion or tumor differentiation for laryngeal cancer, also there were no significant differences in podoplanin expression between glottic and supraglottic regions, but extracapsullar extension is almost statistically significant (p=0,05).
authors.affiliation: Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Kanliada
authors.affiliation: Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ender
authors.initials: E
authors.lastname: Coskunpinar
authors.affiliation: Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Serkan Orhan
authors.affiliation: Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Musteri Oltulu
authors.affiliation: Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Celik
authors.affiliation: Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ayse
authors.initials: A
authors.lastname: Eren
authors.affiliation: Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Ilhan
authors.initials: I
authors.lastname: Yaylim
authors.affiliation: Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Kemal
authors.initials: K
authors.lastname: Deger
keywords: GST-T1; Podoplanin; biomarker; laryngeal carcinoma; squamous cell carcinoma