title: Fluorescence spectral classification of iron deficiency anemia and thalassemia.
abstract: Thalassemia (Thal), sickle cell anemia, and iron deficiency anemia (IDA) are the most common blood disorders in many parts of the world, particularly in developing countries like India and Bangladesh. The well-established diagnostic procedure for them is the complete blood count (CBC); however, there is substantial confusion in discrimination between Thal and IDA blood samples based on such CBC. We propose a new spectral technique for reliable classification between the above two anemias. This is based on the identification and quantification of a certain set of fluorescent metabolites found in the blood samples of patients of Thal and IDA.
authors.affiliation: King Saud University, College of Science, Physics and Astronomy Department, Riyadh 11451, Saudi ArabiadBharathiar University, Research and Development Centre, Coimbatore 641046, India.
authors.forename: Sandhanasamy
authors.initials: S
authors.lastname: Devanesan
authors.affiliation: King Saud University, College of Science, Physics and Astronomy Department, Riyadh 11451, Saudi Arabia.
authors.forename: AlSalhi
authors.initials: A
authors.lastname: Mohamad Saleh
authors.affiliation: Government Arts College for Men, PG and Research Department of Plant Biology and Biotechnology, Nandanam, Chennai 600035, India.
authors.forename: Mani
authors.initials: M
authors.lastname: Ravikumar
authors.affiliation: Government Arts College for Men, PG and Research Department of Plant Biology and Biotechnology, Nandanam, Chennai 600035, India.
authors.forename: Kantharaj
authors.initials: K
authors.lastname: Perinbam
authors.affiliation: King Saud University, College of Science, Physics and Astronomy Department, Riyadh 11451, Saudi Arabia.
authors.forename: Saradh
authors.initials: S
authors.lastname: Prasad
authors.affiliation: King Saud University, College of Medical Sciences, Riyadh 11451, Saudi Arabia.
authors.forename: H Al-Saeed
authors.initials: HA
authors.lastname: Abbas
authors.affiliation: Kidwai Memorial Institute of Oncology, Radiation Oncology Department, Bangalore 560029, India.
authors.forename: Siddanna R
authors.initials: SR
authors.lastname: Palled
authors.affiliation: Rajah Serfoji Government College, Department of Biochemistry, Thanjavur 613005, India.
authors.forename: Karuppaiah
authors.initials: K
authors.lastname: Jeyaprakash
authors.affiliation: King Saud University, College of Science, Physics and Astronomy Department, Riyadh 11451, Saudi Arabia.
authors.forename: Vadivel
authors.initials: V
authors.lastname: Masilamani
mesh_terms: D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood*; D005260:Female; D005182:Flavin-Adenine Dinucleotide / Q000097:blood / Q000737:chemistry; D006801:Humans; D008297:Male; D009243:NAD / Q000097:blood / Q000737:chemistry; D010949:Plasma / Q000737:chemistry*; D012372:ROC Curve; D012815:Signal Processing, Computer-Assisted; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013789:Thalassemia / Q000097:blood*; D055815:Young Adult
chemical_list: D009243:NAD; D005182:Flavin-Adenine Dinucleotide