title: A new cyclopeptide from endophytic Streptomyces sp. YIM 64018.
abstract: One new cyclopeptide, cyclo(L-Phe-L-Ala-L-Phe-Gly), named as vinaceuline (1) and three known cyclodipeptides, cyclo (Phe-Gly), cyclo (Phe-4-hydroxyl-Pro) and cyclo (Phe-Ile) were isolated from broth culture of endophytic Streptomyces YIM 64018 associated with Paraboea sinensis. The planar structure of the new compound was assigned on the basis of 1D and 2D NMR spectroscopic techniques, while t he a bsolute configurations of the amino acid residueswere determined by application of the advanced Marfey method. Cyclotetrapeptides are rarely found as Streptomycete metabolites.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry ofEducation, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Xueqiong
authors.initials: X
authors.lastname: Yang
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry ofEducation, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Yabin
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry ofEducation, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Tianfeng
authors.initials: T
authors.lastname: Peng
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry ofEducation, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Fangfang
authors.initials: F
authors.lastname: Yang
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry ofEducation, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhou
authors.affiliation: Yunnan Institute ofMicrobiology, Yunnan University, Kunming 650091, China.
authors.forename: Lixing
authors.initials: L
authors.lastname: Zhao
authors.affiliation: Yunnan Institute ofMicrobiology, Yunnan University, Kunming 650091, China.
authors.forename: Lihua
authors.initials: L
authors.lastname: Xu
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry ofEducation, School of Chemical Science and Technology,Yunnan University, Kunming 650091, China.
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Ding
mesh_terms: D060026:Endophytes / Q000737:chemistry*; D019684:Magnoliopsida / Q000382:microbiology; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D010456:Peptides, Cyclic; C587191:cyclo(L-Phe-L-Ala-L-Phe-Gly)