title: Perceived challenges and attitudes to regimen and product selection from Italian haemophilia treaters: the 2013 AICE survey.
abstract: Despite great advances in haemophilia care in the last 20 years, a number of questions on haemophilia therapy remain unanswered. These debated issues primarily involve the choice of the product type (plasma-derived vs. recombinant) for patients with different characteristics: specifically, if they were infected by blood-borne virus infections, and if they bear high or low risk of inhibitor development. In addition, the most appropriate treatment regimen in non-inhibitor and inhibitor patients compel physicians operating at the haemophilia treatment centres (HTCs) to take important therapeutic decisions, which are often based on their personal clinical experience rather than on evidence-based recommendations from published literature data. To know the opinion on the most controversial aspects in haemophilia care of Italian expert physicians, who are responsible for common clinical practice and therapeutic decisions, we have conducted a survey among the Directors of HTCs affiliated to the Italian Association of Haemophilia Centres (AICE). A questionnaire, consisting of 19 questions covering the most important topics related to haemophilia treatment, was sent to the Directors of all 52 Italian HTCs. Forty Directors out of 52 (76.9%) responded, accounting for the large majority of HTCs affiliated to the AICE throughout Italy. The results of this survey provide for the first time a picture of the attitudes towards clotting factor concentrate use and product selection of clinicians working at Italian HTCs.
authors.affiliation: Department of Transfusion Medicine and Haematology, Carlo Poma Hospital, Mantova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Franchini
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authors.lastname: Coppola
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authors.lastname: Rocino
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authors.lastname: Zanon
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authors.initials: M
authors.lastname: Morfini
authors.forename: Arianna
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authors.lastname: Accorsi
authors.forename: Anna Brigida
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authors.lastname: Aru
authors.forename: Chiara
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authors.lastname: Biasoli
authors.forename: Isabella
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authors.lastname: Cantori
authors.forename: Giancarlo
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authors.lastname: Castaman
authors.forename: Simone
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authors.lastname: Cesaro
authors.forename: Carlo
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authors.lastname: Ciabatta
authors.forename: Raimondo
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authors.lastname: De Cristofaro
authors.forename: Grazia
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authors.lastname: Delios
authors.forename: Giovanni
authors.initials: G
authors.lastname: Di Minno
authors.forename: Marco
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authors.lastname: D'Incà
authors.forename: Alfredo
authors.initials: A
authors.lastname: Dragani
authors.forename: Cosimo Pietro
authors.initials: CP
authors.lastname: Ettorre
authors.forename: Fabio
authors.initials: F
authors.lastname: Gagliano
authors.forename: Gabriella
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authors.lastname: Gamba
authors.forename: Giorgio
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authors.lastname: Gandini
authors.forename: Paola
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authors.lastname: Giordano
authors.forename: Gaetano
authors.initials: G
authors.lastname: Giuffrida
authors.forename: Paolo
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authors.lastname: Gresele
authors.forename: Caterina
authors.initials: C
authors.lastname: Latella
authors.forename: Matteo
authors.initials: M
authors.lastname: Luciani
authors.forename: Maurizio
authors.initials: M
authors.lastname: Margaglione
authors.forename: Marco
authors.initials: M
authors.lastname: Marietta
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Mazzucconi
authors.forename: Maria
authors.initials: M
authors.lastname: Messina
authors.forename: Angelo Claudio
authors.initials: AC
authors.lastname: Molinari
authors.forename: Lucia Dora
authors.initials: LD
authors.lastname: Notarangelo
authors.forename: Emily
authors.initials: E
authors.lastname: Oliovecchio
authors.forename: Flora
authors.initials: F
authors.lastname: Peyvandi
authors.forename: Gavino
authors.initials: G
authors.lastname: Piseddu
authors.forename: Gina
authors.initials: G
authors.lastname: Rossetti
authors.forename: Vincenza
authors.initials: V
authors.lastname: Rossi
authors.forename: Elena
authors.initials: E
authors.lastname: Santagostino
authors.forename: Mario
authors.initials: M
authors.lastname: Schiavoni
authors.forename: Piercarla
authors.initials: P
authors.lastname: Schinco
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Serino
authors.forename: Annarita
authors.initials: A
authors.lastname: Tagliaferri
authors.forename: Sophie
authors.initials: S
authors.lastname: Testa
mesh_terms: D001779:Blood Coagulation Factors / Q000627:therapeutic use; D019538:Health Care Surveys; D006467:Hemophilia A / Q000188:drug therapy / Q000453:epidemiology*; D006782:Hospitals, Special; D006801:Humans; D007558:Italy; D008505:Medical Staff, Hospital; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires
chemical_list: D001779:Blood Coagulation Factors
keywords: factor concentrates; haemophilia treatment; inhibitor; prophylaxis; survey; viral safety