title: Quantifying the effect of statin use in pre-diabetic phenotypes discovered through association rule mining.
abstract: Prediabetes is the most important risk factor for developing type-2 diabetes mellitus, an important and growing epidemic. Prediabetes is often associated with comorbidities including hypercholesterolemia. While statin drugs are indicated to treat hypercholesterolemia, recent reports suggest a possible increased risk of developing overt diabetes associated with the use of statins. Association rule mining is a data mining technique capable of identifying interesting relationships between risks and treatments. However, it is limited in its ability to accurately calculate the effect of a treatment, as it does not appropriately account for bias and confounding. We propose a novel combination of propensity score matching and association rule mining to account for this bias, and find meaningful associations between a treatment and outcome for various subpopulations. We demonstrate this technique on a real diabetes data set examining the relationship between statin use and diabetes, and identify risk and protective factors previously not clearly defined.
authors.affiliation: University of Minnesota, Minneapolis, MN.
authors.forename: John R
authors.initials: JR
authors.lastname: Schrom
authors.affiliation: Mayo Clinic, Rochester, MN.
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Caraballo
authors.affiliation: Mayo Clinic, Rochester, MN.
authors.forename: M Regina
authors.initials: MR
authors.lastname: Castro
authors.affiliation: University of Minnesota, Minneapolis, MN.
authors.forename: György J
authors.initials: GJ
authors.lastname: Simon
mesh_terms: D057225:Data Mining / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010641:Phenotype; D011236:Prediabetic State / Q000150:complications* / Q000188:drug therapy; D011379:Prognosis; D057216:Propensity Score; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors