title: [Gastroenteropancreatic neuroendocrine tumors: clinical characteristics, diagnosis and prognosis at Hospital Universitario Clínico San Carlos (Madrid)].
abstract: BACKGROUND
  Neuroendocrine tumors are a group of neoplasms arising from the neural crest and endoderm and very heterogeneous as regards localization, clinical behavior, aggressiveness, and prognosis. Pancreas and gastrointestinal tract are the most common sites where neuroendocrine tumors can be found.
  
  
  METHODS
  A review was made of all cases of neuroendocrine tumors diagnosed at Hospital Universitario Clínico San Carlos (HUCSC) from January 2007 to May 2012. Data were compared to the results provided by the Registry of the Spanish Group on Neuroendocrine Tumors (RGETNE).
  
  
  RESULTS
  The study cohort comprised 78 patients. Gastroenteric nonfunctional tumors were the most common neoplasms. Metastases were found at diagnosis in50.6% of patients, with nodal involvement being most prevalent. Tumors located in the rectum were associated to the highestrate of metastasis. Overall 2-year survival rate was 74.8% and was related to sex, Ki-67 expression, and presence of metastasis.
authors.affiliation: Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España. Electronic address: pazdemiguel@telefonica.net.
authors.forename: María Paz
authors.initials: MP
authors.lastname: de Miguel Novoa
authors.affiliation: Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España.
authors.forename: Francisco
authors.initials: F
authors.lastname: Fernández Capel
authors.affiliation: Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España.
authors.forename: Jesús Vicente
authors.initials: JV
authors.lastname: Redondo Sedano
authors.affiliation: Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España.
authors.forename: Margarita
authors.initials: M
authors.lastname: Sellers Carrera
authors.affiliation: Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España.
authors.forename: Verónica
authors.initials: V
authors.lastname: Aranda Jiménez
authors.affiliation: Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España.
authors.forename: Paloma
authors.initials: P
authors.lastname: Ortiz Pereira
authors.affiliation: Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España.
authors.forename: Javier
authors.initials: J
authors.lastname: Sastre Valera
authors.affiliation: Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España.
authors.forename: Luis
authors.initials: L
authors.lastname: Ortega Medina
authors.affiliation: Servicio de Endocrinología, Metabolismo y Nutrición, Hospital Clínico San Carlos, Madrid, España.
authors.forename: José Ángel
authors.initials: JÁ
authors.lastname: Díaz Pérez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000628:therapy; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D013030:Spain; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000628:therapy; D055815:Young Adult
keywords: Gastrointestinal; Neuroendocrine tumors; Pancreatic; Pancreático; Supervivencia; Survival; Tratamiento; Treatment; Tumor neuroendocrino
vernacular_title: Tumores neuroendocrinos gastroenteropancreáticos: características clínicas, proceso diagnóstico y pronóstico en el Hospital Universitario Clínico San Carlos (Madrid).