title: Multiple genetic variants are associated with colorectal cancer risk in the Han Chinese population.
abstract: Colorectal cancer (CRC) is a major health burden worldwide and is the second-leading cause of cancer-related death in Europe. CRC is a complex disease resulting from a series of genetic and epigenetic changes that lead to a stepwise progression from normal mucosa to dysplasia and finally to carcinoma. In this study, we present genetic association results between 25 tag single-nucleotide polymorphisms and CRC in a case-control study (203 cases, 296 controls) of a Han Chinese population. We found that rs1143634 in the interleukin-1β (IL1B) gene and rs1800871 in the interleukin-10 (IL10) gene were associated with increased risk for CRC in the Han Chinese. Further haplotype analysis revealed that the 'GAC' in the SMAD7 (mothers against decapentaplegic homolog 7) gene was found to increase CRC risk (odds ratio=1.48; 95% confidence interval, 1.09-2.01; P=0.012). Our results, combined with previous studies, suggest that IL10, PSCA, IL1B, and SMAD7 are significantly correlated with CRC susceptibility in the Han Chinese population.
authors.affiliation: aDepartment of General Surgery, Tangdu Hospital, Fourth Military Medical University bSchool of Life Sciences, Northwest University cNational Engineering Research Center for Miniaturized Detection Systems, Xi'an dKey Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Tibet University for Nationalities, Xianyang, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Hui Qun
authors.initials: HQ
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Lan
authors.forename: Xue
authors.initials: X
authors.lastname: He
authors.forename: Tian Bo
authors.initials: TB
authors.lastname: Jin
authors.forename: Long Li
authors.initials: LL
authors.lastname: Kang
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D005260:Female; D058851:GPI-Linked Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance / Q000379:methods; D012307:Risk Factors; D051906:Smad7 Protein / Q000235:genetics
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; C508609:IL10 protein, human; D053583:Interleukin-1beta; D009363:Neoplasm Proteins; C110843:PSCA protein, human; C497806:SMAD7 protein, human; D051906:Smad7 Protein; D016753:Interleukin-10