title: New humulenes from Hyptis incana (Labiatae).
abstract: Two new humulene-type sesquiterpenes, named hyptishumulene I (1) and II (2), have been isolated, together with eight known compounds, a humulene-type sesquiterpene (3), a monoterpene (4) and six abietane-type diterpenoids (5-10) from the aerial parts of Hyptis incana (Labiatae). The cytotoxic activity of the isolated compounds against mouse leukemia cells (L1210) was examined. The abietane-type diterpenoids (5-10) showed rather potent growth inhibitory activity (IC50<15 microM), while the new humulene-type compounds (1 and 2) exhibited moderate activity (IC50>50 microM).
authors.affiliation: Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543 Japan. ms@ac.shoyaku.ac.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Satoh
authors.affiliation: Department of Clinical and Biomedical Sciences, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543 Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Satoh
authors.affiliation: Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543 Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Anzai
authors.affiliation: Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashitamagawagakuen, Machida, Tokyo 194-8543 Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ajisawa
authors.affiliation: School ofPharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Matsuzaki
authors.affiliation: School ofPharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan.
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Makino
authors.affiliation: Department of General Studies, College of Humanities and Sciences, Nihon University, 3-25-40 Sakurajosui, Setagaya-ku, Tokyo 156-8550, Japan.
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Fujimotod
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D031331:Hyptis / Q000737:chemistry*; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D015394:Molecular Structure; D000081222:Monocyclic Sesquiterpenes; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000081222:Monocyclic Sesquiterpenes; D010936:Plant Extracts; D012717:Sesquiterpenes; C042686:humulene