title: Association between TLR2, MTR, MTRR, XPC, TP73, TP53 genetic polymorphisms and gastric cancer: a meta-analysis.
abstract: OBJECTIVE
  The aim of our meta-analyses is to test the association between six genetic polymorphisms and gastric cancer.
  
  
  METHODS
  A systematic search was performed for all the available candidate genes and gastric cancer among several online databases including PubMed, Embase, Web of Science, the Cochrane Library, CNKI and Wanfang online libraries. After a comprehensive screening, a total of six genes were harvested for the current meta-analyses. These genes include TLR2 (-196 to -174 ins>del), MTR (rs1805087), MTRR (rs1801394), XPC (rs2228001), TP73 (G4C14-A4T14), and TP53 (rs1042522).
  
  
  RESULTS
  Altogether 49 comparative studies among 11 776 cases and 18 633 controls were involved in our meta-analyses. TP53 rs1042522 polymorphism was shown to be associated with gastric cancer risk under the dominant model (P=0.02, OR=1.03, 95% CI=1.00-1.05). A subgroup meta-analysis indicated a significant association under dominant model between TP53 rs1042522 and gastric cancer in the Eastern Asians (P=0.03, OR=1.17, 95%=1.02-1.34).
  
  
  CONCLUSIONS
  These results suggest that TP53 rs1042522 polymorphism might contribute to the susceptibility of gastric cancer under the dominant model, especially in Eastern Asians.
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China; The Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315000, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Cheng
authors.affiliation: Bank of Blood Products, Ningbo No.2 Hospital, Ningbo, Zhejiang 315010, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Lingyan
authors.affiliation: Department of Neurosurgery, Ningbo First Hospital, Ningbo University, Ningbo, Zhejiang 315010, China.
authors.forename: Huang
authors.initials: H
authors.lastname: Yi
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Cheng
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Huadan
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Xuting
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China.
authors.forename: Xu
authors.initials: X
authors.lastname: Leiting
authors.affiliation: The Affiliated Hospital, Ningbo University, Ningbo, Zhejiang 315000, China. Electronic address: yemeng@nbu.edu.cn.
authors.forename: Ye
authors.initials: Y
authors.lastname: Meng
authors.affiliation: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China. Electronic address: duanshiwei@nbu.edu.cn.
authors.forename: Duan
authors.initials: D
authors.lastname: Shiwei
mesh_terms: D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005287:Ferredoxin-NADP Reductase / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics; D011110:Polymorphism, Genetic; D044469:Racial Groups / Q000235:genetics; D013274:Stomach Neoplasms / Q000235:genetics*; D051195:Toll-Like Receptor 2 / Q000235:genetics; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C495342:TLR2 protein, human; C495901:TP53 protein, human; C000606460:TP73 protein, human; D051195:Toll-Like Receptor 2; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; C086984:XPC protein, human; C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase; D013766:5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; C585801:MTR protein, human