title: Drug therapies in dermatology.
abstract: This article explores the current and emerging therapies for skin disease, with a particular focus on chronic plaque psoriasis and metastatic malignant melanoma. We discuss the current biological therapies used for psoriasis and those on the horizon, including small molecules and biosimilars. We also summarise the recent advances in the use of novel therapeutic agents in other dermatological diseases and outline the promise of translational research and stratified medicine approaches in dermatology. Better matching of patients with therapies is anticipated to have a major effect on both clinical practice and the development of new drugs and diagnostics.
authors.affiliation: Dermatology Centre, Salford Royal NHS Foundation Trust, University of Manchester, Manchester, UK;
authors.forename: Arif
authors.initials: A
authors.lastname: Aslam
authors.forename: Christopher E M
authors.initials: CE
authors.lastname: Griffiths
mesh_terms: D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D003876:Dermatitis, Atopic / Q000188:drug therapy; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D011565:Psoriasis / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D014409:Tumor Necrosis Factor-alpha
keywords: Psoriasis; atopic dermatitis; biological therapies; malignant melanoma; tumour necrosis factor antagonists