title: Mitofusins: ubiquitylation promotes fusion.
abstract: Mitochondrial genes including Mfn2 are at the center of many diseases, underscoring their potential as a therapeutical target. The Chen group now identified 15-oxospiramilactone as a chemical inhibitor of the mammalian deubiquitylase USP30, acting on Mfn1 and Mfn2.
authors.affiliation: Institute for Genetics, Centre for Molecular Medicine (CMMC), Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Zülpicher Str 47a, 50674 Cologne, Germany.
authors.forename: Mafalda
authors.initials: M
authors.lastname: Escobar-Henriques
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D063154:Mitochondrial Dynamics / Q000187:drug effects*; D024101:Mitochondrial Proteins / Q000037:antagonists & inhibitors*; D013869:Thiolester Hydrolases / Q000037:antagonists & inhibitors*
chemical_list: C560615:15-oxospiramilactone; D004224:Diterpenes; D004791:Enzyme Inhibitors; D024101:Mitochondrial Proteins; C532819:Usp30 protein, human; D013869:Thiolester Hydrolases