title: Antiproliferative and antiviral activity of three libraries of adamantane derivatives.
abstract: Three libraries of adamantane derivatives were synthesized and evaluated for antiviral and antiproliferative activities against a broad variety of DNA and RNA viruses. Whereas none of the compounds exhibit antiviral activity at subtoxic concentrations, antiproliferative activity was found against murine leukemia cells (L1210), human T-lymphocyte cells (CEM), and cervix carcinoma cells (HeLa) for 4, 8, and 10.
authors.affiliation: Department of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Zagreb, Croatia.
authors.forename: Nikola
authors.initials: N
authors.lastname: Basarić
authors.forename: Margareta
authors.initials: M
authors.lastname: Sohora
authors.forename: Nikola
authors.initials: N
authors.lastname: Cindro
authors.forename: Kata
authors.initials: K
authors.lastname: Mlinarić-Majerski
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004285:Dogs; D015195:Drug Design; D005347:Fibroblasts / Q000187:drug effects / Q000821:virology; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061985:Madin Darby Canine Kidney Cells; D051379:Mice; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects / Q000821:virology; D014709:Vero Cells; D010948:Viral Plaque Assay
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D054852:Small Molecule Libraries; D000218:Adamantane
keywords: Adamantanes; Antiproliferative activity; Antiviral activity; Phthalimides; Polycyclic compounds; Unnatural amino acids