title: Low birthweight and risk of albuminuria in living kidney donors.
abstract: Low birthweight is linked to hypertension, chronic kidney disease and even end-stage renal disease. We hypothesized that living kidney donors born with lower birthweight may be at increased risk of hypertension, albuminuria, or reduced GFR beyond what is typical following uninephrectomy. Two hundred fifty-seven living kidney donors who donated at the University of Minnesota between 1967 and 2005 underwent iohexol GFR and urinary albumin excretion measurements. Predictors of iohexol GFR <60 mL/min/1.73 m(2), albuminuria, and hypertension were examined using logistic regression. Predictors examined include age at GFR measurement, time since donation, BMI, gender, serum creatinine level (at donation and GFR measurement), systolic and diastolic blood pressure, race, and birthweight. The latter was obtained through self-report and verified through birth certificates and family members. Older age, higher BMI, and time from donation were associated with reduced GFR. Older age and higher BMI were also associated with hypertension. Birthweight was not associated with GFR <60 mL/min/1.73 m(2): OR=0.70, 95% CI (0.28, 1.74), p = 0.45 or hypertension: OR=0.92, 95% CI (0.46, 1.84), p = 0.82 but was associated with albuminuria: OR=0.37, 95% CI (0.15, 0.92), p = 0.03. These data further strengthen the link between low birthweight and potential adverse renal outcomes.
authors.affiliation: Department of Surgery, University of Minnesota, Minneapolis, MN, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Berglund
authors.forename: David
authors.initials: D
authors.lastname: MacDonald
authors.forename: Scott
authors.initials: S
authors.lastname: Jackson
authors.forename: Richard
authors.initials: R
authors.lastname: Spong
authors.forename: Naim
authors.initials: N
authors.lastname: Issa
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Kukla
authors.forename: Scott
authors.initials: S
authors.lastname: Reule
authors.forename: Marc
authors.initials: M
authors.lastname: Weber
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Matas
authors.forename: Hassan N
authors.initials: HN
authors.lastname: Ibrahim
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000209:etiology*; D001794:Blood Pressure; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006801:Humans; D007230:Infant, Low Birth Weight; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000601:surgery; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D017063:Outcome Assessment, Health Care; D011379:Prognosis; D012307:Risk Factors; D020858:Tissue and Organ Harvesting / Q000009:adverse effects*
chemical_list: D003404:Creatinine
keywords: albuminuria; donor; kidney; outcomes; weight