title: 3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs.
abstract: A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.
authors.affiliation: School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, 02138, USA.
authors.forename: David B
authors.initials: DB
authors.lastname: Kolesky
authors.forename: Ryan L
authors.initials: RL
authors.lastname: Truby
authors.forename: A Sydney
authors.initials: AS
authors.lastname: Gladman
authors.forename: Travis A
authors.initials: TA
authors.lastname: Busbee
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Homan
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Lewis
mesh_terms: D062028:Bioprinting; D005109:Extracellular Matrix / Q000737:chemistry; D061307:Human Umbilical Vein Endothelial Cells; D006801:Humans; D020442:Poloxamer / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D011409:Propylene Glycols / Q000737:chemistry; D023822:Tissue Engineering
chemical_list: C116176:PEO-PPO-PEO; D011409:Propylene Glycols; D020442:Poloxamer; D011092:Polyethylene Glycols
keywords: 3D printing; biomaterials; bioprinting; tissue engineering; vasculature