title: Bacterial serine/threonine protein kinases in host-pathogen interactions.
abstract: In bacterial pathogenesis, monitoring and adapting to the dynamically changing environment in the host and an ability to disrupt host immune responses are critical. The virulence determinants of pathogenic bacteria include the sensor/signaling proteins of the serine/threonine protein kinase (STPK) family that have a dual role of sensing the environment and subverting specific host defense processes. STPKs can sense a wide range of signals and coordinate multiple cellular processes to mount an appropriate response. Here, we review some of the well studied bacterial STPKs that are essential virulence factors and that modify global host responses during infection.
authors.affiliation: From the Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Universités de Montpellier II et I, CNRS, UMR 5235, 34095 Montpellier Cedex 05, France.
authors.forename: Marc J
authors.initials: MJ
authors.lastname: Canova
authors.forename: Virginie
authors.initials: V
authors.lastname: Molle
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology* / Q000235:genetics; D001424:Bacterial Infections / Q000201:enzymology*; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D017346:Protein Serine-Threonine Kinases
keywords: Bacterial Signal Transduction; Host-Pathogen Interactions; Protein Secretion; Serine/Threonine Protein Kinase; Virulence Factors