title: [Some aspects of the psychostimulant effect of a phenyl derivative of glutamic acid (RGPU-135, glutarone) in experimental animals].
abstract: Hydrochloride of beta-phenylglutamic acid (RGPU-135, glutarone, neuroglutamine) administered in dosis 13 mg/kg and 26 mg/kg doses increases exercise performance of outbred mice in repeated forced dynamic load test, reduces the intensity of fatigue, and accelerates adaptation to loading. In contrast, beta-phenylethylamine (20 mg/kg) under the same conditions decreases the exercise performance and adaptation capacity and accelerates the development of fatigue. The RGPU-135 compound, similar to typical psychostimulants, in a dose of 26 mg/kg increases the spontaneous motion activity of inbred C57BL/6 mice with the active phenotype of stress response, but not in the BALB/c line mice with the passive phenotype. The RGPU-135 exhibits a psychostimulant activity without an "exhaustive" effect characteristic of psychostimulants.
authors.forename: I N
authors.initials: IN
authors.lastname: Tiurenkov
authors.forename: V V
authors.initials: VV
authors.lastname: Bagmetova
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Chernysheva
authors.forename: M A
authors.initials: MA
authors.lastname: Iarkova
mesh_terms: D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects*; D010627:Phenethylamines / Q000494:pharmacology; D010807:Physical Endurance / Q000187:drug effects*; D011619:Psychotropic Drugs / Q000494:pharmacology
chemical_list: D000697:Central Nervous System Stimulants; D010627:Phenethylamines; D011619:Psychotropic Drugs; C581791:RGPU-135; C029261:phenethylamine; D018698:Glutamic Acid