title: Effect of weight loss on the cardiovascular risk profile of obese patients with psoriasis.
abstract: Psoriasis is associated with obesity and other cardiovascular risk factors including endothelial dysfunction. We aimed to investigate the effects of weight loss on the cardiovascular risk profile of obese patients with psoriasis. A randomised controlled study was conducted in which we measured the microvascular endothelial function with peripheral arterial tonometry (PAT), selected plasma markers of endothelial function, and traditional cardiovascular risk factors in 60 obese patients with psoriasis. The participants were randomised to either low-energy diet (n = 30) providing 800-1,000 kcal/day for 8 weeks followed by 8 weeks of reduced food intake reaching 1,200 kcal/day or normal healthy foods (n = 30) for 16 weeks. The intervention group lost significantly more weight than controls, which resulted in significant reductions of diastolic blood pressure, resting heart rate, total cholesterol, VLDL cholesterol, triglyceride, plasma glucose, glycated haemoglobin, and tissue plasminogen activator inhibitor. Microvascular endothelial function assessed by PAT remained unchanged. We conclude that certain components of the cardiovascular risk profile of obese patients with psoriasis can be significantly improved by weight reduction.
authors.affiliation: Department of Dermato-Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark.
authors.forename: Peter
authors.initials: P
authors.lastname: Jensen
authors.forename: Claus
authors.initials: C
authors.lastname: Zachariae
authors.forename: Robin
authors.initials: R
authors.lastname: Christensen
authors.forename: Nina R W
authors.initials: NR
authors.lastname: Geiker
authors.forename: Bente K
authors.initials: BK
authors.lastname: Schaadt
authors.forename: Steen
authors.initials: S
authors.lastname: Stender
authors.forename: Arne
authors.initials: A
authors.lastname: Astrup
authors.forename: Peter R
authors.initials: PR
authors.lastname: Hansen
authors.forename: Lone
authors.initials: L
authors.lastname: Skov
mesh_terms: D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D031204:Caloric Restriction; D002318:Cardiovascular Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D015897:Comorbidity; D003718:Denmark / Q000453:epidemiology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006339:Heart Rate; D006801:Humans; D008055:Lipids / Q000097:blood; D008365:Manometry; D055806:Microvessels / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000178:diet therapy* / Q000453:epidemiology / Q000503:physiopathology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D065840:Protective Factors; D011565:Psoriasis / Q000175:diagnosis / Q000453:epidemiology*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008055:Lipids; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; C517652:hemoglobin A1c protein, human