title: Megavoltage X-ray Dose Enhancement with Gold Nanoparticles in Tumor Bearing Mice.
abstract: One of the applications of gold nanoparticles (GNPs) in medicine is radiation dose-enhancing effect. Although there are many simulations, in vitro and in vivo evidence that GNPs can enhance significantly the radiation dose effect of orthovoltage beams. These beams compared with megavoltage (MV) beams, have limited applications in radiotherapy. In order to evaluate GNPs radiosensitization performance with MV beams in-vivo, we used two most clinically used X-ray beams (6 and 18 MV) with the dose of 20 Gy for each mouse. Intratumoral injection of 50 nm GNPs with the concentration of 5 mg ml(-1) was applied to melanoma tumor growing in the left leg of 7 to 8 mice in 4 control and treatment groups of C57BL/6 mice. Albeit, using 10 cm plexiglass jig phantom in the beam path improved the radiation - treatments, the statistical differences between groups were not significant. According to the results, it is concluded that mice can be treated with smaller tumors and higher concentrations of GNPs in MV radiation beams.
authors.affiliation: Department of Medical Physics, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Sayyed Hossein
authors.initials: SH
authors.lastname: Mousavie Anijdan
authors.affiliation: Department of Medical Physics and Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Seyyed Rabi
authors.initials: SR
authors.lastname: Mahdavi
authors.affiliation: Department of Medical Physics and Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Shirazi
authors.affiliation: Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Zarrinfard
authors.affiliation: Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Jamshid
authors.initials: J
authors.lastname: Hajati
keywords: Gold nanoparticles (GNPs); megavoltage X-ray; radiation dose enhancement; tumor