title: Intestinal macrophages and DCs close the gap on tolerance.
abstract: CD103(+) dendritic cells (DCs) must acquire soluble food antigens from the gut lumen to induce oral tolerance. In this issue of Immunity, Mazzini et al. (2014), report that CX3CR1(+) macrophages capture such antigen and transfer it to the DCs by a route involving gap junctions.
authors.affiliation: Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel. Electronic address: shakhar@weizmann.ac.il.
authors.forename: Guy
authors.initials: G
authors.lastname: Shakhar
authors.affiliation: Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Masha
authors.initials: M
authors.lastname: Kolesnikov
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology*; D015703:Antigens, CD / Q000378:metabolism*; D000073883:CX3C Chemokine Receptor 1; D003713:Dendritic Cells; D005512:Food Hypersensitivity / Q000276:immunology*; D017629:Gap Junctions / Q000276:immunology*; D007108:Immune Tolerance; D039001:Integrin alpha Chains / Q000378:metabolism*; D008264:Macrophages / Q000276:immunology*; D019707:Receptors, Chemokine / Q000378:metabolism*
chemical_list: D000941:Antigens; D015703:Antigens, CD; D000073883:CX3C Chemokine Receptor 1; C471885:Cx3cr1 protein, mouse; D039001:Integrin alpha Chains; D019707:Receptors, Chemokine; C091367:alpha E integrins