title: Structural brain changes in prenatal methamphetamine-exposed children.
abstract: The global use of methamphetamine (MA) has increased substantially in recent years, but the effect of MA on brain structure in prenatally exposed children is understudied. Here we aimed to investigate potential changes in brain volumes and cortical thickness of children with prenatal MA-exposure compared to unexposed controls. Eighteen 6-year old children with MA-exposure during pregnancy and 18 healthy controls matched for age, gender and socio-economic background underwent structural imaging. Brain volumes and cortical thickness were assessed using Freesurfer and compared using ANOVA. Left putamen volume was significantly increased, and reduced cortical thickness was observed in the left hemisphere of the inferior parietal, parsopercularis and precuneus areas of MA-exposed children compared to controls. Compared to control males, prenatal MA-exposed males had greater volumes in striatal and associated areas, whereas MA-exposed females predominantly had greater cortical thickness compared to control females. In utero exposure to MA results in changes in the striatum of the developing child. In addition, changes within the striatal, frontal, and parietal areas are in part gender dependent.
authors.affiliation: MRC Unit on Anxiety & Stress Disorders, Department of Psychiatry, Stellenbosch University, P.O. Box 19063, Tygerberg, 7505, Cape Town, South Africa, aroos@sun.ac.za.
authors.forename: Annerine
authors.initials: A
authors.lastname: Roos
authors.forename: Gaby
authors.initials: G
authors.lastname: Jones
authors.forename: Fleur M
authors.initials: FM
authors.lastname: Howells
authors.forename: Dan J
authors.initials: DJ
authors.lastname: Stein
authors.forename: Kirsten A
authors.initials: KA
authors.lastname: Donald
mesh_terms: D001921:Brain / Q000187:drug effects* / Q000254:growth & development / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008694:Methamphetamine / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D008694:Methamphetamine