title: Isolation of the plant hormone (+)-abscisic acid as an antimycobacterial constituent of the medicinal plant endophyte Nigrospora sp.
abstract: An extract of the endophytic fungus Nigropsora sp. (isolate TC2-054) from the Canadian medicinal plant Fragaria virginiana exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra. Bioassay guided fractionation revealed that linoleic acid derivatives and the plant hormone (+)-abscisic acid (ABA) were responsible for the observed antimycobacterial activity. This activity of ABA has not been previously reported.
authors.affiliation: Department of Biology, University of New Brunswick, 100 Tucker Park Rd, Saint John, NB, Canada, E2L 4L5.
authors.forename: Trevor N
authors.initials: TN
authors.lastname: Clark
authors.affiliation: Department of Biology, University of New Brunswick, 100 Tucker Park Rd, Saint John, NB, Canada, E2L 4L5.
authors.forename: Katelyn
authors.initials: K
authors.lastname: Ellsworth
authors.affiliation: Department of Biology, University of New Brunswick, 100 Tucker Park Rd, Saint John, NB, Canada, E2L 4L5.
authors.forename: Haoxin
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Biology, University of New Brunswick, 100 Tucker Park Rd, Saint John, NB, Canada, E2L 4L5.
authors.forename: John A
authors.initials: JA
authors.lastname: Johnson
authors.affiliation: Department of Biology, University of New Brunswick, 100 Tucker Park Rd, Saint John, NB, Canada, E2L 4L5.
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Gray
mesh_terms: D000040:Abscisic Acid / Q000302:isolation & purification*; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D060026:Endophytes / Q000737:chemistry*; D031985:Fragaria / Q000382:microbiology*; D057809:HEK293 Cells; D006801:Humans; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D000040:Abscisic Acid