title: The skin prick test is not useful in the diagnosis of the immediate type food allergy tolerance acquisition.
abstract: BACKGROUND
  Some studies have been reported about positioning of SPT in the diagnosis of food allergy. On the other hand, it is not yet clear about the positioning of SPT in the diagnosis of tolerance acquisition of the immediate type food allergy.
  
  
  METHODS
  The retrospective study had been conducted for 236 egg allergic children (51.3 months in mean), 127 milk allergic children (53.4 months), and 96 wheat allergic children (42.6 months). The retrospective analysis of serum nonspecific and antigen-specific IgE levels, SPT, and OFC had been conducted for each allergic patient. All OFC had been conducted to verify the acquisition of tolerance against eliminated food.
  
  
  RESULTS
  The OFC was positive in 61 (25.8%) hen's egg allergies, 34 (26.8%) milk allergies and 33 (34.4%) wheat allergies. The greatest AUC for each allergen is as following; hen's egg for egg white specific IgE at 0.745, milk/histamine (wheal) index at 0.718, and wheat for wheal size at 0.597. For the predictive decision points, the highest accuracy rate was at 25.8% for an egg white wheal of 9.5mm, at 26.8% for a milk wheal of 9.5mm, and at 34.4% for a wheal of 6.5mm.
  
  
  CONCLUSIONS
  As a result of this analysis, the diagnostic accuracy of SPT had not been satisfactory to judge the acquisition of tolerance in allergic children for eggs, milk and wheat. Therefore, this is not a strong evidence to testify the tolerance of the immediate type food allergy.
authors.affiliation: Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan; Department of Pediatrics, National Hospital Organization, National Sagamihara Hospital, Kanagawa, Japan.
authors.forename: Takanori
authors.initials: T
authors.lastname: Imai
authors.affiliation: Department of Pediatrics, National Hospital Organization, National Sagamihara Hospital, Kanagawa, Japan.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Yanagida
authors.affiliation: Department of Pediatrics, National Hospital Organization, National Kumamoto Medical Center, Kumamoto, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Ogata
authors.affiliation: Department of Pediatrics, National Hospital Organization, National Sagamihara Hospital, Kanagawa, Japan.
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Komata
authors.affiliation: Department of Pediatrics, National Hospital Organization, National Sagamihara Hospital, Kanagawa, Japan.
authors.forename: Morimitsu
authors.initials: M
authors.lastname: Tomikawa
authors.affiliation: Department of Allergy, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, National Sagamihara Hospital, Kanagawa, Japan.
authors.forename: Motohiro
authors.initials: M
authors.lastname: Ebisawa
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D002417:Cattle; D002648:Child; D002675:Child, Preschool; D004531:Eggs / Q000009:adverse effects; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007223:Infant; D008297:Male; D008892:Milk / Q000009:adverse effects; D012372:ROC Curve; D012189:Retrospective Studies; D012882:Skin Tests; D021182:Wheat Hypersensitivity / Q000175:diagnosis / Q000276:immunology
chemical_list: D000485:Allergens; D007073:Immunoglobulin E