title: Activity of the adrenergic nerve system in the airways permeability of healthy persons.
abstract: OBJECTIVE
  In this work, role of the adrenergic nerve system (alpha1 and beta2) in adjustment of the bronchomotor tonus in healthy people was researched.
  
  
  METHODS
  Parameters of the lung function are determined by Body plethysmography. Raw and ITGV were registered and SRaw was calculated as well. Aerosolization is done with standard aerosolizing machines - Asema.
  
  
  RESULTS
  Results gained shows that following the blockade of beta-2 adrenergic receptor with Propranolol (20 mg-aerosol), stimulation of alpha adrenergic receptor with Oxedrine (120 mg-aerosol) and blockage of these receptors with Tolazoline (20 mg-aerosol), does not change significantly the bronchomotor tonus of the tracheobronchial tree (p > 0.1). Meanwhile, stimulation of the beta-2 adrenergic receptor with Hexoprenaline (2 inh × 0.2 mg) is associated with a significant increase of the peripheral resistance of the airways (p < 0.01).
  
  
  CONCLUSIONS
  This suggests that the activity of the alpha1-adrenergic receptor, unlike the activity of the beta2-adrenergic receptor in the healthy people smooth musculature, is not significant and as such is insufficient to oppose to the tonic activities of the cholinergic system.
authors.affiliation: Department of Pediatric, Faculty of Medicine. University of Prishtina. Clinical Centre, Prishtina, Kosova.
authors.forename: Njazi
authors.initials: N
authors.lastname: Gashi
authors.affiliation: Smartmed, St.Rexhep Krasniqi, EXDC, Prishtina, Kosova.
authors.forename: Pëllumb
authors.initials: P
authors.lastname: Islami
authors.affiliation: Liri-Med, St. Agim Ramadani, SHPK, Prishtina, Kosova.
authors.forename: Lirim
authors.initials: L
authors.lastname: Mustafa
authors.affiliation: Department of Surgery, Faculty of Medicine. University of Prishtina, Clinical Centre, Prishtina, Kosova.
authors.forename: Halit
authors.initials: H
authors.lastname: Maloku
authors.affiliation: Department of Pharmacy, Faculty of Medicine. University of Prishtina. Clinical Centre, Prishtina, Kosova.
authors.forename: Arta
authors.initials: A
authors.lastname: Veseli
authors.affiliation: Department of Clinical Pharmacology, Faculty of Medicine. University of Prishtina. Clinical Centre, Prishtina, Kosova.
authors.forename: Hilmi
authors.initials: H
authors.lastname: Islami
keywords: Hexoprenaline; Oxedrine; Propranolol; Tolazoline; and Histamine.