title: Insights into phagocytosis-coupled activation of pattern recognition receptors and inflammasomes.
abstract: A decade of work shows that the core function of phagocytosis in engulfment and destruction of microorganisms is only a small facet of the full spectrum of roles for phagocytosis in the immune system. The regulation of phagocytosis and its outcomes by inflammatory pattern recognition receptors (PRRs) is now followed by new studies strengthening this concept and adding further complexity to the relationship between phagocytosis and innate immune signaling. Phagocytosis forms the platform for activation of distinct members of the Toll-like receptor family, and even dictates their signaling outcomes. In many cases, phagocytosis is a necessary precedent to the activation of cytosolic PRRs and assembly of canonical and non-canonical inflammasomes, leading to strong pro-inflammatory responses and inflammatory cell death.
authors.affiliation: Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, United States.
authors.forename: Julien
authors.initials: J
authors.lastname: Moretti
authors.affiliation: Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, United States. Electronic address: Julie.blander@mssm.edu.
authors.forename: J Magarian
authors.initials: JM
authors.lastname: Blander
mesh_terms: D000818:Animals; D016923:Cell Death / Q000276:immunology; D003600:Cytosol / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D011992:Endosomes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate; D058847:Inflammasomes / Q000378:metabolism*; D009696:Nucleic Acids / Q000378:metabolism; D010586:Phagocytes / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D010587:Phagocytosis / Q000276:immunology*; D010588:Phagosomes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D051192:Receptors, Pattern Recognition / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology
chemical_list: D058847:Inflammasomes; D009696:Nucleic Acids; D051192:Receptors, Pattern Recognition