title: Survival from breast cancer in patients with CHEK2 mutations.
abstract: The purpose of this study is to estimate 10-year survival rates for patients with early onset breast cancer, with and without a CHEK2 mutation and to identify prognostic factors among CHEK2-positive breast cancer patients. 3,592 women with stage I to stage III breast cancer, diagnosed at or below age 50, were tested for four founder mutations in the CHEK2 gene. Information on tumor characteristics and on treatments received was retrieved from medical records. Dates of death were obtained from the Poland Vital Statistics Registry. Survival curves were generated for the mutation-positive and -negative sub-cohorts. Predictors of survival were determined among CHEK2 carriers using the Cox proportional hazards model. 3,592 patients were eligible for the study, of whom 140 (3.9 %) carried a CHEK2-truncating mutation and 347 (9.7 %) carried a missense mutation. The mean follow-up was 8.9 years. The 10-year survival for all CHEK2 mutation carriers was 78.8 % (95 % CI 74.6-83.2 %) and for non-carriers was 80.1 % (95 % CI 78.5-81.8 %). Among women with a CHEK2-positive breast cancer, the adjusted hazard ratio associated with ER-positive status was 0.88 (95 % CI 0.48-1.62). Among women with an ER-positive breast cancer, the adjusted hazard ratio associated with a CHEK2 mutation was 1.31 (95 % CI 0.97-1.77). The survival of women with breast cancer and a CHEK2 mutation is similar to that of patients without a CHEK2 mutation.
authors.affiliation: Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Połabska 4 St, 70-115, Szczecin, Poland.
authors.forename: T
authors.initials: T
authors.lastname: Huzarski
authors.forename: C
authors.initials: C
authors.lastname: Cybulski
authors.forename: D
authors.initials: D
authors.lastname: Wokolorczyk
authors.forename: A
authors.initials: A
authors.lastname: Jakubowska
authors.forename: T
authors.initials: T
authors.lastname: Byrski
authors.forename: J
authors.initials: J
authors.lastname: Gronwald
authors.forename: P
authors.initials: P
authors.lastname: Domagała
authors.forename: M
authors.initials: M
authors.lastname: Szwiec
authors.forename: D
authors.initials: D
authors.lastname: Godlewski
authors.forename: E
authors.initials: E
authors.lastname: Kilar
authors.forename: E
authors.initials: E
authors.lastname: Marczyk
authors.forename: M
authors.initials: M
authors.lastname: Siołek
authors.forename: R
authors.initials: R
authors.lastname: Wiśniowski
authors.forename: H
authors.initials: H
authors.lastname: Janiszewska
authors.forename: D
authors.initials: D
authors.lastname: Surdyka
authors.forename: R
authors.initials: R
authors.lastname: Sibilski
authors.forename: P
authors.initials: P
authors.lastname: Sun
authors.forename: J
authors.initials: J
authors.lastname: Lubiński
authors.forename: S A
authors.initials: SA
authors.lastname: Narod
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000401:mortality* / Q000473:pathology; D064447:Checkpoint Kinase 2 / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017720:Molecular Epidemiology; D009154:Mutation; D011044:Poland / Q000453:epidemiology; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
chemical_list: D064447:Checkpoint Kinase 2; C578634:CHEK2 protein, human