title: [Efficacy and safety of recombinant tissue plasminogen activator in thrombolytic therapy of vena caval thromboembolism].
abstract: OBJECTIVE
  To explore the efficacy and safety of recombinant tissue plasminogen activator (rt-PA) in thrombolytic therapy of vena caval thromboembolism.
  
  
  METHODS
  Ninety patients diagnosed of vena caval thromboembolism by ultrasound or angiography of inferior vena cava were randomly assigned into 2 groups. rt-PA and parental anticoagulant were given to the patients in the treatment group while those in the control group received only parental anticoagulation. D-dimer, fibrinogen and fibrinogen degradation product were analyzed after 2-week treatment. All subjects were closely monitored for the occurrence of severe complications.
  
  
  RESULTS
  The changes from baseline in the above laboratory parameters in the treatment group were significantly greater than those of the control group (P < 0.05). No severe complications occurred in either group.
  
  
  CONCLUSIONS
  rt-PA is both safe and effective for the thrombolytic therapy of vena caval thromboembolism.
authors.affiliation: Department of Vascular Surgery, Jishuitan Hospial, Beijing 100035, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.affiliation: Department of Vascular Surgery, Jishuitan Hospial, Beijing 100035, China.
authors.forename: Jian-long
authors.initials: JL
authors.lastname: Liu
authors.affiliation: Department of Vascular Surgery, Jishuitan Hospial, Beijing 100035, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Tian
authors.affiliation: Department of Vascular Surgery, Jishuitan Hospial, Beijing 100035, China. Email: jiaweimaxwell@vip.sina.com.
authors.forename: Peng
authors.initials: P
authors.lastname: Jiang
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014682:Vena Cava, Inferior / Q000473:pathology*; D020246:Venous Thrombosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator