title: Does a dry protein undergo a glass transition?
abstract: Bovine serum albumin (BSA) with extremely low hydration level 0.04, which is usually defined as dry, has been investigated in the temperature range between 200 and 340 K by incoherent inelastic neutron scattering using the neutron time-of-flight spectrometer FOCUS (PSI, Switzerland). Anomalous temperature behavior has been revealed for relaxational and low-frequency vibrational dynamics of BSA in the vicinity of 250 K. The mean-square atomic displacement has been shown to exhibit a change in the slope of temperature dependence near the same temperature. The presented results point out that the glass-like transition occurs in the dry protein.
authors.affiliation: A.F. Ioffe Physical Technical Institute , ul. Politekhnicheskaya 26, 194032 Saint-Petersburg, Russian Federation.
authors.forename: Anna V
authors.initials: AV
authors.lastname: Frontzek
authors.forename: Serge V
authors.initials: SV
authors.lastname: Strokov
authors.forename: Jan Peter
authors.initials: JP
authors.lastname: Embs
authors.forename: Sergey G
authors.initials: SG
authors.lastname: Lushnikov
mesh_terms: D000818:Animals; D002417:Cattle; D003890:Desiccation; D005898:Glass / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D044366:Transition Temperature; D014732:Vibration
chemical_list: D012710:Serum Albumin, Bovine