title: Coils versus gelatin particles with or without intraarterial antibiotics for partial splenic embolization: a comparative evaluation.
abstract: OBJECTIVE
  To compare the efficacy, complications, and inflammatory levels in partial splenic embolization (PSE) with coils or gelatin sponge (GS) particles with or without intraarterial antibiotic agents.
  
  
  METHODS
  Forty-four patients with hypersplenism treated by PSE were assessed. GS particles were used in 31 patients, and coils were used in 13 patients. In 17 of the 31 patients who received GS, GS suspended in antibiotic solution was injected via the splenic artery. In the other 14 patients, antibiotic agents were not used. In all 13 coil group patients, an antibiotic solution was intraarterially injected before embolization. Platelet counts were compared between the GS and coil groups. Complications and serum C-reactive protein (CRP) levels were compared among the three groups.
  
  
  RESULTS
  There were no significant differences in platelet counts and platelet increased ratios at 6 months (10.0 × 10(4)/µL and 193% in the GS group vs 9.0 × 10(4)/µL and 221% in the coil group), and no significant differences in frequencies of complications. However, one splenic abscess occurred in a patient treated with GS without antibiotics, resulting in death. The mean serum CRP level in the GS with antibiotic group at 2 weeks was significantly lower than in the other two groups.
  
  
  CONCLUSIONS
  The efficacy of PSE is similar with the use of coils versus GS particles. Prophylactic intraarterial antibiotic treatment could be useful in preventing inflammatory reactions after PSE.
authors.affiliation: Department of Radiology, Nara Medical University, Kashihara.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Masada
authors.affiliation: Department of Radiology, Nara Medical University, Kashihara. Electronic address: toshihir@bf6.so-net.ne.jp.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.affiliation: Department of Radiology, Nara Prefectural Mimuro Hospital, Sango.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakaguchi
authors.affiliation: Department of Radiology, Saiseikai Suita Hospital, Suita.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakagomi
authors.affiliation: Department of Radiology, Saiseikai Suita Hospital, Suita.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Miura
authors.affiliation: Department of Radiology, Shitennouji Hospital, Osaka.
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Hidaka
authors.affiliation: Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya.
authors.forename: Yozo
authors.initials: Y
authors.lastname: Sato
authors.affiliation: Department of Radiology, Nara Prefectural Mimuro Hospital, Sango; Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Nagoya.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sato
authors.affiliation: Department of Radiology, Nara Prefectural Nara Hospital, Nara.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Inoue
authors.affiliation: Department of Radiology, Higashi Osaka City General Hospital, Higashiosaka, Japan.
authors.forename: Kinya
authors.initials: K
authors.lastname: Furuich
authors.affiliation: Department of Radiology, Nara Medical University, Kashihara.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nishiofuku
authors.affiliation: Department of Radiology, Nara Medical University, Kashihara.
authors.forename: Kimihiko
authors.initials: K
authors.lastname: Kichikawa
mesh_terms: D000038:Abscess / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002511:Cephalosporins / Q000008:administration & dosage*; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D005260:Female; D005780:Gelatin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D006971:Hypersplenism / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D007249:Inflammation / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control; D018836:Inflammation Mediators / Q000097:blood; D007269:Injections, Intra-Arterial; D007564:Japan; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012189:Retrospective Studies; D013157:Splenic Artery / Q000000981:diagnostic imaging*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D015415:Biomarkers; D002511:Cephalosporins; D018836:Inflammation Mediators; D005780:Gelatin; D002097:C-Reactive Protein; C045693:flomoxef