title: Diabetes mellitus and intermittent claudication: a cross-sectional study of 920 claudicants.
abstract: BACKGROUND
  Diabetes mellitus (DM) and intermittent claudication (IC) are frequently associated health conditions. Our hypothesis is that the nature, severity and quality of life (QoL) of patients with IC and DM are worse than those of claudicant patients without diabetes.
  
  
  METHODS
  An observational, cross-sectional and multicentre study of 920 patients with IC, divided into two groups: diabetic (n = 477) and non-diabetic (n = 443). For each group, we examined clinical and biological characteristics (including levels of glucose and lipids), the ankle-brachial index (ABI), responses to the Walking Impairment Questionnaire (WIQ) and the European Quality of Life-5 Dimensions (EQ-5D) questionnaire.
  
  
  RESULTS
  Compared with claudicant patients without diabetes, claudicants with diabetes were older (p < 0.001), more likely to be female (p = 0.006), with a higher BMI (p < 0.001), more likely to have a sedentary lifestyle (p < 0.001) and to be a non-smoker (p < 0.001). Claudicant patients with diabetes also had significantly more cardiovascular risk factors (p < 0.001), more frequent ischaemic cardiopathy (p = 0.023) and chronic renal failure (p = 0.002), and fewer prior ictus events (p = 0.003). No significant differences between groups were found with respect to blood pressure, levels of cholesterol or triglycerides. The mean ABI of diabetic-IC patients was slightly lower than IC patients without diabetes (p = 0.016). All WIQ subdomains scores were significantly lower (p < 0.001), indicating poorer walking ability, in claudicant and diabetic patients with compared with those without diabetes. The mean E5-QD global scores and the mean EQ-5D visual analogue scale in the whole series were 0.58 (SD = 0.21) and 55.04 (SD = 21.30), respectively. Both E5-QD scores were significantly lower, indicating poorer QoL, in claudicant patients with diabetes than claudicant patients without diabetes (p < 0.001).
  
  
  CONCLUSIONS
  Patients with IC and DM had more risk cardiovascular factors, cardiovascular conditions, disability and worse haemodynamic status and QoL than claudicant patients without diabetes.
authors.affiliation: Hospital Universitario de Salamanca e IBSAL, Salamanca, Spain. lozano@usal.es.
authors.forename: Francisco S
authors.initials: FS
authors.lastname: Lozano
authors.forename: José R
authors.initials: JR
authors.lastname: González-Porras
authors.forename: José R
authors.initials: JR
authors.lastname: March
authors.forename: José M
authors.initials: JM
authors.lastname: Lobos
authors.forename: Eduardo
authors.initials: E
authors.lastname: Carrasco
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ros