title: A unified stereodivergent strategy for prostaglandin and isoprostanoid synthesis.
abstract: Acetoxyfulvene surrended to asymmetric Diels-Alder cycloaddition, paving the way to the development of a unified strategy for the stereodivergent synthesis of both prostaglandins and isoprostanoids. In fact, the cycloadduct was subsequently converted to a common intermediate, which through two different stereoselective pathways afforded the two lactones 1 and 2, which are key building blocks in the synthesis of prostaglandins and isoprostanoids, respectively.
authors.affiliation: Department of Chemistry, University of Pavia , Viale Taramelli, 10, 27100 Pavia, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Valli
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiesa
authors.forename: Andrea
authors.initials: A
authors.lastname: Gandini
authors.forename: Alessio
authors.initials: A
authors.lastname: Porta
authors.forename: Giovanni
authors.initials: G
authors.lastname: Vidari
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Zanoni
mesh_terms: D061565:Cycloaddition Reaction; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D011453:Prostaglandins / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D011453:Prostaglandins