title: Analytical solutions of actin-retrograde-flow in a circular stationary cell: a mechanical point of view.
abstract: The network of actin filaments in the lamellipodium (LP) of stationary and migrating cells flows in a retrograde direction, from the membrane periphery toward the cell nucleus. We have theoretically studied this phenomenon in the circular stationary (fully spread) cells. Adopting a continuum view on the LP actin network, new closed-form solutions are provided for the actin-retrograde-flow (ARF) in a polar coordinate system. Due to discrepancy in the mechanical models of the actin network in the ARF regime, solutions are provided for both assumptions of solid and fluid behavior. Other involved phenomena, including polymerizing machine at the membrane periphery, cytosol drag, adhesion friction, and membrane tension, are also discussed to provide an overall quantitative view on this problem.
authors.affiliation: School of Mechanical Engineering, Sharif University of Technology, Tehran, Iran, ghasemi@mech.sharif.edu.
authors.forename: V A
authors.initials: VA
authors.lastname: Ghasemi
authors.forename: B
authors.initials: B
authors.lastname: Firoozabadi
authors.forename: M S
authors.initials: MS
authors.lastname: Saidi
mesh_terms: D000199:Actins / Q000502:physiology*; D000818:Animals; D001696:Biomechanical Phenomena; D002465:Cell Movement / Q000502:physiology; D002468:Cell Physiological Phenomena; D003600:Cytosol / Q000502:physiology; D004548:Elasticity; D006801:Humans; D057446:Hydrodynamics; D055641:Mathematical Concepts; D008954:Models, Biological; D011554:Pseudopodia / Q000502:physiology
chemical_list: D000199:Actins