title: [Association of adiponectin gene polymorphisms +45T/G with gestational diabetes mellitus and neonate birth weight].
abstract: OBJECTIVE
  To determine the association of single-nucleotide polymorphisms (SNPs)+45T/G of adiponectin gene with gestational diabetes mellitus (GDM) and neonate birth weight.
  
  
  METHODS
  A total of 264 GDM and 272 pregnant women with normal glucose (NG) were enrolled. DNA was successfully extracted from peripheral blood leucocyte samples. And SNPs+45T/G of adiponectin gene were examined. We also analyzed differences in the genotypic distribution and allelic frequencies in SNP+45T/G of adiponectin gene among GDM group with different neonate birth weights.
  
  
  RESULTS
  There was no significant difference between two groups with respects to SNP +45T/G polymorphisms of adiponectin gene (P > 0.05). But significant genotypic difference existed in SNP+45T/G among three GDM groups with different birth weights. Frequencies of T allele were significantly higher in the GDM group with higher birth weight, 68.75% in GDM group with macrosomia and 72.86% in GDM group with 3000-4000 g birth weight (both P < 0.01). And there was no significant difference in SNP +45T/G polymorphisms of adiponectin gene between GDM women and NG group with macrosomia.
  
  
  CONCLUSIONS
  SNP +45T/G polymorphisms of adiponectin gene are not associated with GDM. However, SNP+45T/G polymorphisms of adiponectin gene of GDM women are closely associated with neonate birth weigh. The G/T polymorphisms of SNP+45 of adiponectin are not obviously associated with a higher occurrence of macrosomia in GDM women.
authors.affiliation: Department of Obstetrics, Beijing Obstetrics & Gynecology Hospital, Capital Medical University, Beijing 100026, China.
authors.forename: Guang-hui
authors.initials: GH
authors.lastname: Li
authors.affiliation: Department of Obstetrics, Beijing Obstetrics & Gynecology Hospital, Capital Medical University, Beijing 100026, China.
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Kong
authors.affiliation: Department of Obstetrics, Beijing Obstetrics & Gynecology Hospital, Capital Medical University, Beijing 100026, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Obstetrics, Beijing Obstetrics & Gynecology Hospital, Capital Medical University, Beijing 100026, China. Email: zhangwy9921@hotmail.com.
authors.forename: Wei-yuan
authors.initials: WY
authors.lastname: Zhang
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000483:Alleles; D001724:Birth Weight; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000235:genetics*; D005260:Female; D005320:Fetal Macrosomia / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin