title: Association between adiponectin concentrations and diabetic retinopathy in patients with type 2 diabetes: a meta analysis.
abstract: BACKGROUND
  Numerous studies have investigated the association between adiponectin concentrations and diabetic retinopathy (DR) caused by type 2 diabetic mellitus. However, the results remain conflicting. We performed a meta-analysis to explore the relationship between adiponectin concentrations and risk of DR caused by type 2 diabetic mellitus from published articles.
  
  
  METHODS
  A published literature search was performed through the PubMed, Cochrane Library, EMBASE, Science Citation Index Expanded database, Chinese CNKI, and Chinese Wan Fang databases for articles published in English and Chinese. Pooled standardized mean differences (SMDs) and 95% confidence intervals (95% CIs) were calculated using random or fixed effects model. Heterogeneity between studies was assessed using the Cochrane Q test and I(2) statistics.
  
  
  RESULTS
  Nineteen studies with a total of 1 545 cases and 1 502 controls were retrieved. The original meta-analysis found a significant difference in the adiponectin concentrations between the DR and non-DR (NDR) groups. After excluding the high heterogeneity studies, the second meta-analysis also demonstrated the significant association (SMD (95% CI) = -0.62 (-0.80 to -0.44), P = 0.0001). According to the available data, there was statistical significance in the adiponectin concentrations considering non-proliferative DR (NPDR) versus NDR, PDR versus NPDR in Chinese populations with high heterogeneity.
  
  
  CONCLUSIONS
  Adiponectin concentrations are correlated with DR; however, the relationship between adiponectin concentrations and DR needs more in-depth investigations with larger sample sizes.
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, China; Second Hospital of Harbin City, Harbin, Heilongjiang 150081, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Fan
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, China. Email: wuqunhong@163.com.
authors.forename: Qunhong
authors.initials: Q
authors.lastname: Wu
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Hao
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, China.
authors.forename: Ning
authors.initials: N
authors.lastname: Ning
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Kang
authors.affiliation: Department of Social Medicine, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Cui
authors.affiliation: Department of Preventive Medicine, Medical School of Ningbo University, Ningbo, Zhejiang 315021, China.
authors.forename: Ruohong
authors.initials: R
authors.lastname: Liu
authors.affiliation: Department of Preventive Medicine, Medical School of Ningbo University, Ningbo, Zhejiang 315021, China.
authors.forename: Liyuan
authors.initials: L
authors.lastname: Han
mesh_terms: D052242:Adiponectin / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003930:Diabetic Retinopathy / Q000097:blood* / Q000209:etiology
chemical_list: D052242:Adiponectin