title: Patterns of lymph node recurrence after radical surgery impacting on survival of patients with pT1-3N0M0 thoracic esophageal squamous cell carcinoma.
abstract: The aim of this study was to investigate how patterns of lymph nodes recurrence after radical surgery impact on survival of patients with pT1-3N0M0 thoracic esophageal squamous cell carcinoma. One hundred eighty consecutive patients with thoracic esophageal squamous cell carcinoma underwent radical surgery, and the tumors were staged as pT1-3N0M0 by postoperative pathology. Lymph nodes recurrence was detected with computed tomography 3-120 months after the treatment. The patterns of lymph nodes recurrence including stations, fields and locations of recurrent lymph nodes, and impacts on patterns of survival were statistically analyzed. There was a decreasing trend of overall survival with increasing stations or fields of postoperative lymph nodes involved (all P<0.05). Univariate analysis showed that stations or fields of lymph nodes recurrence, and abdominal or cervical lymph nodes involved were prognostic factors for survival (all P<0.05). Cox analyses revealed that the field was an independent factor (P<0.05, odds ratio=2.73). Lymph nodes involved occurred predominantly in cervix and upper mediastinum (P<0.05). In conclusion, patterns of lymph node recurrence especially the fields of lymph nodes involved are significant prognostic factors for survival of patients with pT1-3N0M0 thoracic esophageal squamous cell carcinoma.
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China. ; Department of Radiology, Sichuan Cancer Hospital and Institute (The Second People's Hospital of Sichuan Province), Chengdu, Sichuan, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Chen
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Tian-Wu
authors.initials: TW
authors.lastname: Chen
authors.affiliation: Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Zhi-Jia
authors.initials: ZJ
authors.lastname: Fang
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhang
authors.affiliation: Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Zhen-Lin
authors.initials: ZL
authors.lastname: Li
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Tang
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Li
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Radiology, University of Michigan Health System, Ann Arbor, MI, USA.
authors.forename: Zishu
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000077277:Esophageal Squamous Cell Carcinoma; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D016017:Odds Ratio; D011184:Postoperative Period; D016016:Proportional Hazards Models; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed
keywords: Esophageal Squamous Cell Carcinoma; Lymph Node Recurrence; Radical Esophagectomy; Thorax; Tomography, X-Ray Computed