title: Effect of conjugated linoleic acid mixtures and different edible oils in body composition and lipid regulation in mice.
abstract: BACKGROUND
  Evidences suggest that commercial and natural conjugated linoleic acids (CLA) differentially affect nutritional status and lipid metabolism.
  
  
  OBJECTIVE
  To investigate the differential effect of two types of CLA preparations supplemented to dietary fats containing different proportions of n-9, n-6 and n-3 fatty acids (FA) on body composition, triacylglycerol (TG) levels and lipid metabolism in mice.
  
  
  METHODS
  Growing mice were fed diets containing olive, maize and rapeseed oils supplemented with an equimolecular mixture of CLA (mix-CLA) or a rumenic acid (RA)-rich oil for 30 days. Body weight gain, carcass composition, tissue weights, plasma and tissue TG levels, and lipid regulation parameters were evaluated.
  
  
  RESULTS
  Independently of the dietary fats, mix-CLA decreased body weight gain and fat depots related to lower energy efficiency, hepatomegaly, increase of serum TG and decrease of muscle TG. Rapeseed oil prevented the hepatic steatosis observed with mix-CLA supplementation to olive and maize oils by increasing TG secretion. RA-rich oil supplementation decreased fat depots without hepatomegaly, hepatic steatosis and hypertriglyceridemia. Olive oil, by an equilibrium between FA uptake/oxidation, prevented the increase of muscle TG induced by the RA-rich oil supplementation to maize and rapeseed oils.
  
  
  CONCLUSIONS
  The proportions of dietary unsaturated FA modulated the different mix-CLA and RA-rich oil response to lipid metabolism in mice. Finally, rapeseed oil prevented the hepatic steatosis induced by mix-CLA, and the most beneficial effects of RA-rich oil were observed when supplemented to olive oil, due to the reduced lipid accretion without changes in TG levels.
authors.affiliation: Cátedra Bromatología y Nutrición. Facultad de Bioquímica y Ciencias Biológicas. Universidad Nacional del Litoral. Santa Fe. Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Santa Fe. Argentina.. cbernal@fbcb.unl.edu.ar.
authors.forename: María Victoria
authors.initials: MV
authors.lastname: Scalerandi
authors.affiliation: Cátedra Bromatología y Nutrición. Facultad de Bioquímica y Ciencias Biológicas. Universidad Nacional del Litoral. Santa Fe. Argentina..
authors.forename: Marcela Aida
authors.initials: MA
authors.lastname: Gonzalez
authors.affiliation: Cátedra Bromatología y Nutrición. Facultad de Bioquímica y Ciencias Biológicas. Universidad Nacional del Litoral. Santa Fe. Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Santa Fe. Argentina..
authors.forename: Juliana
authors.initials: J
authors.lastname: Saín
authors.affiliation: Cátedra Bromatología y Nutrición. Facultad de Bioquímica y Ciencias Biológicas. Universidad Nacional del Litoral. Santa Fe. Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Santa Fe. Argentina..
authors.forename: Ana Clara
authors.initials: AC
authors.lastname: Fariña
authors.affiliation: Cátedra Bromatología y Nutrición. Facultad de Bioquímica y Ciencias Biológicas. Universidad Nacional del Litoral. Santa Fe. Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Santa Fe. Argentina.. cbernal@fbcb.unl.edu.ar.
authors.forename: Claudio Adrián
authors.initials: CA
authors.lastname: Bernal
mesh_terms: D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood; D019787:Linoleic Acid / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D051379:Mice; D014280:Triglycerides / Q000097:blood
chemical_list: D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D014280:Triglycerides; D019787:Linoleic Acid