title: A systems biology-based investigation into the therapeutic effects of Gansui Banxia Tang on reversing the imbalanced network of hepatocellular carcinoma.
abstract: Several complex molecular events are involved in tumorigenesis of hepatocellular carcinoma (HCC). The interactions of these molecules may constitute the HCC imbalanced network. Gansui Banxia Tang (GSBXT), as a classic Chinese herbal formula, is a popular complementary and alternative medicine modality for treating HCC. In order to investigate the therapeutic effects and the pharmacological mechanisms of GSBXT on reversing HCC imbalanced network, we in the current study developed a comprehensive systems approach of integrating disease-specific and drug-specific networks, and successfully revealed the relationships of the ingredients in GSBXT with their putative targets, and with HCC significant molecules and HCC related pathway systems for the first time. Meanwhile, further experimental validation also demonstrated the preventive effects of GSBXT on tumor growth in mice and its regulatory effects on potential targets.
authors.affiliation: 1] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China [2].
authors.forename: Yanqiong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: 1] 302 Hospital of PLA, Beijing 100039, China [2].
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Guo
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Danhua
authors.initials: D
authors.lastname: Wang
authors.affiliation: 302 Hospital of PLA, Beijing 100039, China.
authors.forename: Ruisheng
authors.initials: R
authors.lastname: Li
authors.affiliation: 302 Hospital of PLA, Beijing 100039, China.
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Li
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Zhenli
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Institute of Basic Theory, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Zhiqian
authors.initials: Z
authors.lastname: Song
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Lin
authors.affiliation: 302 Hospital of PLA, Beijing 100039, China.
authors.forename: Zhiyan
authors.initials: Z
authors.lastname: Li
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Na
authors.initials: N
authors.lastname: Lin
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation / Q000187:drug effects; D019295:Computational Biology; D030562:Databases, Protein; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D060066:Protein Interaction Maps / Q000187:drug effects; D014183:Transplantation, Heterologous
chemical_list: D004365:Drugs, Chinese Herbal