title: Lactobacillus gasseri SBT2055 reduces postprandial and fasting serum non-esterified fatty acid levels in Japanese hypertriacylglycerolemic subjects.
abstract: BACKGROUND
  Lactobacillus gasseri SBT2055 (LG2055) inhibits dietary fat absorption in rats and exerts preventive effects on abdominal adiposity in rats and humans. The present study aimed to evaluate the effects of LG2055 on postprandial serum lipid responses in Japanese subjects with hypertriacylglycerolemia after the intake of oral fat-loading test (OFLT) meals.
  
  
  METHODS
  We conducted a single-blind, placebo-controlled, within-subject, repeated-measure intervention trial. Twenty subjects initially ingested the fermented milk (FM) without LG2055 for 4 weeks (control FM period), followed by a 4-week washout period, and then consumed FM containing LG2055 for 4 weeks (active FM period). The subjects were asked to consume FM at 200 g/day. At the end of each 4-week period, an 8-h OFLT was conducted. Blood samples were collected at fasting and every hour for 8 h after OFLT meal intake. Thereafter, postprandial serum non-esterified fatty acid (NEFA) and triacylglycerol (TAG) levels and fasting blood parameters were measured.
  
  
  RESULTS
  The OFLT showed that the postprandial serum NEFA levels from 120 to 480 min and the postprandial serum TAG level at 120 min in the active FM period were significantly (P < 0.05) lower than those in the control FM period. The fasting serum NEFA level in the active FM period significantly (P < 0.001) decreased at week 4 from the initial period compared with the control FM period.
  
  
  CONCLUSIONS
  The consumption of probiotic LG2055 reduced postprandial and fasting serum NEFA levels, suggesting its possible contribution to the reduction of the risk for obesity and type 2 diabetes mellitus.
  
  
  BACKGROUND
  UMIN000011605.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ogawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kadooka
authors.forename: Ken
authors.initials: K
authors.lastname: Kato
authors.forename: Bungo
authors.initials: B
authors.lastname: Shirouchi
authors.affiliation: Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School of Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan. masaos@agr.kyushu-u.ac.jp.
authors.forename: Masao
authors.initials: M
authors.lastname: Sato
mesh_terms: D043302:Cultured Milk Products / Q000382:microbiology; D005215:Fasting / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000628:therapy*; D007564:Japan; D007778:Lactobacillus / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D019936:Probiotics / Q000008:administration & dosage*; D016037:Single-Blind Method; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D005230:Fatty Acids, Nonesterified; D014280:Triglycerides