title: The impact of Vitamin D Replacement on Glucose Metabolism.
abstract: OBJECTIVE
  We investigated the impact of vitamin D supplementation on glucose metabolism in Vitamin D-deficient patients with prediabetes.
  
  
  METHODS
  A total of 66 subjects with the mean ages 52.2±9.9 years were included in this prospective and a 6-month follow-up study between 2008-2010. Vitamin D deficient patients (<25ng/ml) were supplemented with oral Vitamin D.
  
  
  RESULTS
  Vitamin D deficiency (<25ng/ml) was found in 93.9% of the patients. Post replacement Vitamin D levels increased significantly and insulin, HbA1c, and HOMA-IR decreased significantly following Vitamin D replacement. Conclusion : We found Vitamin D deficiency was very common in our study population. In Vitamin D deficient patients, supplementation treatment improved insulin resistance and glycemic parameters. Vitamin D replacement may be a promising intervention for the primary prevention of insulin resistance syndromes.
authors.affiliation: Parildar H, Department of Family Medicine, Baskent University, Turkey.
authors.forename: Parildar
authors.initials: P
authors.lastname: H
authors.affiliation: Cigerli O, Department of Family Medicine, Baskent University, Turkey.
authors.forename: Cigerli
authors.initials: C
authors.lastname: O
authors.affiliation: Unal DA, Department of Endocrinology, Baskent University, Turkey.
authors.forename: Unal
authors.initials: U
authors.lastname: DA
authors.affiliation: Gulmez O, Family Practitioner, Department of Family Medicine, Baskent University, Istanbul Hospital, Istanbul, Turkey.
authors.forename: Gulmez
authors.initials: G
authors.lastname: O
authors.affiliation: Gulmez O, Family Practitioner, Department of Family Medicine, Baskent University, Istanbul Hospital, Istanbul, Turkey.
authors.forename: Demirag
authors.initials: D
authors.lastname: Ng
keywords: Insulin resistance; Prediabetes; Vitamin D deficiency