title: HDL cholesterol levels and weight are the main determinants of subclinical atherosclerosis in the young with type 1 diabetes and suitable glycaemic control.
abstract: The aim of this study was to evaluate subclinical atherosclerosis and related factors in young type 1 diabetes (T1D) patients and healthy peers. Carotid intima-media thickness (cIMT) and anthropometric/laboratorial data were obtained for 83 T1D patients (mean age 19.5 ± 4.0 years, disease duration 9.8 ± 4.8 years) and for 36 matched healthy subjects. Considering all the participants as one group, male sex (p = 0.008), weight (p = 0.016) and T1D (p < 0.001) were positively associated with a higher cIMT. High-density lipoprotein (HDL) (p = 0.036) was negatively associated with cIMT in T1D. In the male T1D patients, HDL ≤47.5 mg/dL had a sensitivity of 87.5% and specificity of 57% (p = 0.035) in detecting those belonging to a higher cIMT tercile. In conclusion, weight and T1D were associated with increased cIMT. HDL levels ≤47.5 mg/dL were related to a higher cIMT in male T1D patients.
authors.affiliation: Endocrinology Division, Diabetes Center, Department of Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil.
authors.forename: Camila S
authors.initials: CS
authors.lastname: Pinto
authors.forename: Janaina M
authors.initials: JM
authors.lastname: Lana
authors.forename: Monica A L
authors.initials: MA
authors.lastname: Gabbay
authors.forename: Joao R
authors.initials: JR
authors.lastname: de Sa
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Dib
mesh_terms: D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight / Q000502:physiology*; D059168:Carotid Intima-Media Thickness; D008076:Cholesterol, HDL / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL
keywords: Type 1 diabetes; carotid intima-media thickness; high-density lipoprotein (HDL) cholesterol; weight