title: Modelling of long-term and short-term mechanisms of arterial pressure control in the cardiovascular system: an object-oriented approach.
abstract: A mathematical model that provides an overall description of both the short- and long-term mechanisms of arterial pressure regulation is presented. Short-term control is exerted through the baroreceptor reflex while renal elimination plays a role in long-term control. Both mechanisms operate in an integrated way over the compartmental model of the cardiovascular system. The whole system was modelled in MODELICA, which uses a hierarchical object-oriented modelling strategy, under the DYMOLA simulation environment. The performance of the controlled system was analysed by simulation in light of the existing hypothesis and validation tests previously performed with physiological data, demonstrating the effectiveness of both regulation mechanisms under physiological and pathological conditions.
authors.affiliation: Dpt. de Ing. de Sistemas y Automatica, E.T.S.I. Industriales, Campus de Teatinos, 29071 Malaga, Spain. Electronic address: canete@isa.uma.es.
authors.forename: J
authors.initials: J
authors.lastname: Fernandez de Canete
authors.affiliation: Dpt. de Tecnologia Electronica, E.T.S.I. Informatica, Av. Reina Mercedes, 41010 Sevilla, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Luque
authors.affiliation: Dpt. de Tecnologia Electronica, E.T.S.I. Informatica, Av. Reina Mercedes, 41010 Sevilla, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Barbancho
authors.affiliation: Dpt. de Ing. de Sistemas y Automatica, E.T.S.I. Industriales, Campus de Teatinos, 29071 Malaga, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Munoz
mesh_terms: D062186:Arterial Pressure / Q000502:physiology*; D017704:Baroreflex; D003198:Computer Simulation; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000502:physiology; D008955:Models, Cardiovascular; D011381:Programming Languages
keywords: Cardiovascular system; DYMOLA simulation environment; MODELICA programming language; Object-oriented modelling; Pressure control