title: Association between high-sensitivity cardiac troponin T and N-terminal pro-brain natriuretic peptide in a community based population.
abstract: BACKGROUND
  N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) are excellent biomarkers for detecting heart failure and subclinical myocardial injury. However, it remains unclear whether subclinical myocardial injury is associated with NT-proBNP elevation in a community based population.
  
  
  METHODS
  In a community based study, levels of hs-cTnT and of NT-proBNP were determined in 1 497 participants older than 45 years. The lower detection limit of the hs-cTnT assay used in the present study was 0.003 ng/ml. The association of hs-cTnT levels and NT-proBNP levels was analyzed.
  
  
  RESULTS
  When the subjects with undetectable (<0.003 ng/ml), intermediate (0.003-0.014 ng/ml), and elevated (≥0.014 ng/ml) levels of hs-cTnT were compared (r = 0.175, P < 0.001), a strong association between the hs-cTnT levels and NT-proBNP levels was observed (β = -0.206, P < 0.001; β = -0.118, P < 0.001, respectively). In multivariable analyses, older age and hs-cTnT were positively and independently associated with NT-proBNP levels (β = 0.341, P < 0.001; β = 0.143, P < 0.001, respectively), and male gender and the levels of eGFR were inversely and independently associated with NT-proBNP levels. When the subjects with normal or elevated NT-proBNP were analyzed separately, the hs-cTnT level was not an independent predictor for the NT-proBNP level in the normal NT-proBNP group, whereas the hs-cTnT level was the only independent predictor for NT-proBNP level in the elevated NT-proBNP group (β = 0.399, P < 0.01).
  
  
  CONCLUSIONS
  In this community based population, NT-proBNP elevation was common. In addition to female gender and older age, subclinical myocardial injury indicated by the hs-cTnT level was another important factor in NT-proBNP elevation.
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China; Department of Geriatric Cardiology, Navy General Hospital, Beijing 100048, China.
authors.forename: Ruyi
authors.initials: R
authors.lastname: Xu
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Email: yeping@sina.com.
authors.forename: Ping
authors.initials: P
authors.lastname: Ye
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Leiming
authors.initials: L
authors.lastname: Luo
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Li
authors.initials: L
authors.lastname: Sheng
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wu
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Wenkai
authors.initials: W
authors.lastname: Xiao
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zheng
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.affiliation: Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Tiehui
authors.initials: T
authors.lastname: Xiao
mesh_terms: D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain