title: Navigating the multilayered organization of eukaryotic signaling: a new trend in data integration.
abstract: The ever-increasing capacity of biological molecular data acquisition outpaces our ability to understand the meaningful relationships between molecules in a cell. Multiple databases were developed to store and organize these molecular data. However, emerging fundamental questions about concerted functions of these molecules in hierarchical cellular networks are poorly addressed. Here we review recent advances in the development of publically available databases that help us analyze the signal integration and processing by multilayered networks that specify biological responses in model organisms and human cells.
authors.affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland.
authors.forename: Tapesh
authors.initials: T
authors.lastname: Santra
authors.affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland ; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland ; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland.
authors.forename: Walter
authors.initials: W
authors.lastname: Kolch
authors.affiliation: Systems Biology Ireland, University College Dublin, Belfield, Dublin, Ireland ; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin, Ireland ; School of Medicine and Medical Science, University College Dublin, Belfield, Dublin, Ireland.
authors.forename: Boris N
authors.initials: BN
authors.lastname: Kholodenko
mesh_terms: D000818:Animals; D019295:Computational Biology; D016208:Databases, Factual; D055808:Drug Discovery; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D018511:Systems Integration