title: Plant natural products as an anti-lipid droplets accumulation agent.
abstract: Recently people often suffer from unhealthy energy metabolism balance as they tend to take more energy than required. Normally, excess energy taken in is converted into triglyceride and stored in adipocyte as lipid droplets. Recent studies have suggested that irregular accumulation of triglyceride in adipocyte might be a cause of many metabolic diseases. Thus, the awareness of the detrimental effects on health of excessive lipid droplets accumulation (LDA) has urged the development or finding of drugs to counter this effect, including those from botanical origins. This review summarized recent progress in this field from the viewpoint of crude drug studies with references to their anti-LDA activity. Possible mechanisms involved in their anti-LDA effect and isolations of the relevant bioactive compounds were also discussed.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo, 142-8501, Japan.
authors.forename: Chin Piow
authors.initials: CP
authors.lastname: Wong
authors.forename: Toshio
authors.initials: T
authors.lastname: Kaneda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts