title: Porcine incisional hernia model: Evaluation of biologically derived intact extracellular matrix repairs.
abstract: We compared fascial wounds repaired with non-cross-linked intact porcine-derived acellular dermal matrix versus primary closure in a large-animal hernia model. Incisional hernias were created in Yucatan pigs and repaired after 3 weeks via open technique with suture-only primary closure or intraperitoneally placed porcine-derived acellular dermal matrix. Progressive changes in mechanical and biological properties of porcine-derived acellular dermal matrix and repair sites were assessed. Porcine-derived acellular dermal matrix-repaired hernias of additional animals were evaluated 2 and 4 weeks post incision to assess porcine-derived acellular dermal matrix regenerative potential and biomechanical changes. Hernias repaired with primary closure showed substantially more scarring and bone hyperplasia along the incision line. Mechanical remodeling of porcine-derived acellular dermal matrix was noted over time. Porcine-derived acellular dermal matrix elastic modulus and ultimate tensile stress were similar to fascia at 6 weeks. The biology of porcine-derived acellular dermal matrix-reinforced animals was more similar to native abdominal wall versus that with primary closure. In this study, porcine-derived acellular dermal matrix-reinforced repairs provided more complete wound healing response compared with primary closure.
authors.affiliation: LifeCell Corporation, Inc., Branchburg, NJ, USA.
authors.forename: Gary A
authors.initials: GA
authors.lastname: Monteiro
authors.affiliation: LifeCell Corporation, Inc., Branchburg, NJ, USA.
authors.forename: Aubrey I
authors.initials: AI
authors.lastname: Delossantos
authors.affiliation: LifeCell Corporation, Inc., Branchburg, NJ, USA.
authors.forename: Neil L
authors.initials: NL
authors.lastname: Rodriguez
authors.affiliation: LifeCell Corporation, Inc., Branchburg, NJ, USA.
authors.forename: Paarun
authors.initials: P
authors.lastname: Patel
authors.affiliation: LifeCell Corporation, Inc., Branchburg, NJ, USA.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Franz
authors.affiliation: LifeCell Corporation, Inc., Branchburg, NJ, USA ; Department of Biomedical Engineering, The College of New Jersey, Ewing, NJ, USA.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Wagner
keywords: Incisional hernia; Strattice; biologic mesh; biologic tissue matrix; fascial wounds