title: Prevalence and risk factors of human papillomavirus infection types 16/18/45 in a cohort of French females aged 15-23 years.
abstract: Investigation of the prevalence and risk factors of human papillomavirus (HPV) infection is the basis for developing prophylactic strategies against cervical cancer, especially for young women. This study aimed to assess the prevalence and risk factors of HPV infection among a cohort of sexually active young French women eligible for catch-up vaccination. Between 1997 and 2007, 2163 women aged 15-23 years attending consultations at the department of gynecology in the Hospital of Besançon (France) were screened for high risk HPV (HR HPV) infection. Risk factors were investigated through a questionnaire sent to all participants in 2010. HPV DNA was detected by HC2 and Probe Set assays. The overall prevalence for HR HPV and HPV16, 18 and/or HPV45 was 44.6% (95% CI, 42.5-46.7%) and 19% (95% CI, 17.3-20.7%), respectively. The response rate to the questionnaire was 22.6%. The prevalence of independent risk factors (age older than 19, smoking, and oral contraception) for HPV 16/18/45 infection in this population was less than 20%. Based on this study, HPV vaccination should be offered not only to teenage girls, but also to young women, regardless of their sexual activity.
authors.affiliation: Univ Franche-Comte, F-25000 Besancon, France; EA 3181, FED4234, F-25000 Besancon, France.
authors.forename: Ariane
authors.initials: A
authors.lastname: Baudu
authors.affiliation: Univ Franche-Comte, F-25000 Besancon, France; EA 3181, FED4234, F-25000 Besancon, France; CHU Besancon, F-25000, France.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Prétet
authors.affiliation: Univ Franche-Comte, F-25000 Besancon, France; EA 3181, FED4234, F-25000 Besancon, France; CHU Besancon, F-25000, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Riethmuller
authors.affiliation: EA 3181, FED4234, F-25000 Besancon, France; CHU Besancon, F-25000, France.
authors.forename: Morgane
authors.initials: M
authors.lastname: Chotard
authors.affiliation: Univ Franche-Comte, F-25000 Besancon, France; EA 3181, FED4234, F-25000 Besancon, France; CHU Besancon, F-25000, France. Electronic address: christiane.mougin@univ-fcomte.fr.
authors.forename: Christiane
authors.initials: C
authors.lastname: Mougin
authors.affiliation: Univ Franche-Comte, F-25000 Besancon, France; EA 3181, FED4234, F-25000 Besancon, France; CHU Besancon, F-25000, France.
authors.forename: Mariette
authors.initials: M
authors.lastname: Mercier
mesh_terms: D000293:Adolescent; D000328:Adult; D052685:Alphapapillomavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D015331:Cohort Studies; D003276:Contraceptives, Oral; D005260:Female; D005602:France / Q000453:epidemiology; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D065006:Papanicolaou Test; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D053918:Papillomavirus Vaccines; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000517:prevention & control; D055815:Young Adult
chemical_list: D003276:Contraceptives, Oral; D053918:Papillomavirus Vaccines
keywords: Epidemiology; Genotyping; HPV infection; Screening; Young females