title: Anterior corpus callosotomy combined with anterior temporal resection with amygdalohippocampectomy: outcome in a patient with congenital bilateral perisylvian syndrome.
abstract: Congenital bilateral perisylvian syndrome (CBPS) is characterized by epilepsy, cognitive deficits, pseudobulbar palsy and diplegia of the facial, pharyngeal and masticatory muscles. Epilepsy has been described in nearly 90% of affected patients. The epilepsy is usually severe and pharmacoresistant in about 55 percent of CBPS patients. Until now, only 12 cases of surgical treatment on CBPS have been reported; the surgical treatment is usually corpus callosotomy. In this paper, we describe a previously unreported combination of anterior corpus callosotomy plus anterior temporal lobectomy with amygdalohippocampectomy for a patient with CBPS, resulting in a satisfactory clinical outcome. Based on this case, we suggest that palliative focal resective surgery combined with anterior corpus callosotomy should be considered when a predominance of the epileptiform discharges suggests focal onset in patients with CBPS. Meanwhile, the clinical decision to adopt this combination surgery must be based on a thorough pre-surgical evaluation, and should take into account the clinical, radiological, and EEG features.
authors.affiliation: The Second Affiliated Hospital, Zhejiang University College of Medicine, Department of Neurosurgery, Hangzhou, China.
authors.forename: Zhu
authors.initials: Z
authors.lastname: Junming
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yuanyuan
authors.forename: Feng
authors.initials: F
authors.lastname: Fang
authors.forename: Fu
authors.initials: F
authors.lastname: Weiming
authors.forename: Hays
authors.initials: H
authors.lastname: Ryan
authors.forename: Zhang
authors.initials: Z
authors.lastname: Jianmin
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Xiao
authors.forename: Chen
authors.initials: C
authors.lastname: Shuda
mesh_terms: D000015:Abnormalities, Multiple / Q000523:psychology / Q000601:surgery*; D000293:Adolescent; D000679:Amygdala / Q000601:surgery*; D038481:Anterior Temporal Lobectomy / Q000379:methods*; D000927:Anticonvulsants / Q000627:therapeutic use; D003337:Corpus Callosum / Q000601:surgery*; D004351:Drug Resistance; D004569:Electroencephalography; D005260:Female; D006624:Hippocampus / Q000601:surgery*; D006801:Humans; D008607:Intellectual Disability / Q000523:psychology / Q000601:surgery*; D007360:Intelligence; D008279:Magnetic Resonance Imaging; D054220:Malformations of Cortical Development / Q000523:psychology / Q000601:surgery*; D009460:Neurologic Examination; D019635:Neurosurgical Procedures / Q000379:methods*; D012640:Seizures / Q000209:etiology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants