title: Masking level differences--a diffusion tensor imaging and functional MRI study.
abstract: In our previous study we investigated Masking Level Differences (MLD) using functional Magnetic Resonance Imaging (fMRI), but were unable to confirm neural correlations for the MLD within the auditory cortex and inferior colliculus. Here we have duplicated conditions from our previous study, but have included more participants and changed the study site to a new location with a newer scanner and presentation system. Additionally, Diffusion Tensor Imaging (DTI) is included to allow investigation of fiber tracts that may be involved with MLDs. Twenty participants were included and underwent audiometric testing and MRI scanning. The current study revealed regions of increased and decreased activity within the auditory cortex when comparing the combined noise and signal of the dichotic MLD stimuli (N0Sπ and NπS0) with N0S0. Furthermore, we found evidence of inferior colliculus involvement. Our DTI findings show strong correlations between DTI measures within the brainstem and signal detection threshold levels. Patterns of correlation when the signal was presented only to the right ear showed an extensive network in the left hemisphere; however, the opposite was not true for the signal presented only to the left ear. Our current study was able to confirm what we had previously hypothesized using fMRI, while extending our investigation of MLDs to include the characteristics of connecting neural pathways.
authors.affiliation: Department of Nuclear Medicine, State University of New York at Buffalo, Buffalo, New York, United States of America.
authors.forename: David S
authors.initials: DS
authors.lastname: Wack
authors.affiliation: Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York at Buffalo, Buffalo, New York, United States of America.
authors.forename: Paul
authors.initials: P
authors.lastname: Polak
authors.affiliation: Toshiba America Medical Systems Inc., Tustin, California, United States of America.
authors.forename: Jon
authors.initials: J
authors.lastname: Furuyama
authors.affiliation: Department of Rehabilitation Science, State University of New York at Buffalo, Buffalo, New York, United States of America.
authors.forename: Robert F
authors.initials: RF
authors.lastname: Burkard
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006309:Hearing; D006801:Humans; D007245:Inferior Colliculi / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009434:Neural Pathways; D009474:Neurons / Q000473:pathology; D009622:Noise; D055815:Young Adult