title: Clinicopathologic analysis and syndecan-1 and Ki-67 expression in calcifying cystic odontogenic tumors, dentinogenic ghost cell tumor, and ghost cell odontogenic carcinoma.
abstract: OBJECTIVE
  Benign and malignant tumor cells can express altered adhesion properties, and these features can be associated with their proliferative and invasive characteristics. This study aimed to evaluate syndecan-1 and Ki-67 expression in ghost cell-containing odontogenic tumors.
  
  
  METHODS
  Clinical data were retrieved from laboratory records, and hematoxylin-eosin-stained slides and sections, labeled with monoclonal antibodies anti-syndecan-1 and anti-Ki-67 using the immunoperoxidase technique, were evaluated.
  
  
  RESULTS
  Included were 21 central calcifying cystic odontogenic tumors (CCOTs) (4 associated with odontoma), 2 peripheral CCOTs, 1 dentinogenic ghost cell tumor, and 1 ghost cell odontogenic carcinoma (GCOC). Syndecan-1 was mainly expressed in cells resembling stellate reticulum and in stromal cells from the fibrous capsule. The mean Ki-67 labeling index was 4.1% (49.3% for GCOC), but it was not associated with syndecan-1 expression.
  
  
  CONCLUSIONS
  Syndecan-1 is variably expressed in cells resembling the stellate reticulum, stromal cells, and basal cells and might be associated with the biology of these tumors.
authors.affiliation: Oral Pathology, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Wagner
authors.initials: W
authors.lastname: Gomes da Silva
authors.affiliation: Professor, Oral Pathology, State University of Rio de Janeiro; Oral Pathology, Estácio de Sá University, Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Teresa Cristina
authors.initials: TC
authors.lastname: Ribeiro Bartholomeu Dos Santos
authors.affiliation: Professor, Oral Pathology, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Márcia Grillo
authors.initials: MG
authors.lastname: Cabral
authors.affiliation: Professor, Oral Pathology, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil.
authors.forename: Rebeca Souza
authors.initials: RS
authors.lastname: Azevedo
authors.affiliation: Professor, Oral Pathology, State University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: ramoafop@yahoo.com.
authors.forename: Fábio Ramôa
authors.initials: FR
authors.lastname: Pires
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D003803:Dentigerous Cyst / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D018333:Odontogenic Cyst, Calcifying / Q000378:metabolism / Q000473:pathology; D009807:Odontogenic Cysts / Q000378:metabolism* / Q000473:pathology; D009808:Odontogenic Tumors / Q000378:metabolism* / Q000473:pathology; D053668:Syndecan-1 / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D053668:Syndecan-1