title: Milk improved the metabolic syndrome in obese β rats.
abstract: The response of adult spontaneously obese rats from the IIMb/Beta strain fed a high calcium skimmed milk diet (MHCa), high calcium from carbonate (HCa) and a normal AIN 93 diet during 45 days was evaluated. Body weight, food intake and fecal fat excretion were measured. At the end of the experiment rats were euthanized, abdominal fat pads and livers were excised and weighed. Blood and liver triacylglycerols, total cholesterol and fractions were quantified. Body weight increase and abdominal fat pads in the MHCa group were significantly lower than in the other two. Plasma triacylglycerols, total and LDL-cholesterol were diminished in the MHCa group. Fecal lipid excretion was increased in the adult MHCa group. Total liver lipids and triacylglycerols showed a significant diminution in the MHCa group. These results suggest that calcium and other bioactive compounds from milk, most probably present in whey fraction, and not calcium carbonate exerted an "anti-obesity" effect on these rats.
authors.affiliation: área Bromatología y Nutrición, Departamento Ciencias de los Alimentos y Medio Ambiente, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Santa Fe, Argentina. E-mail: molguin@fbioyf.unr.edu.ar.
authors.forename: María Catalina
authors.initials: MC
authors.lastname: Olguín
authors.forename: Marta D
authors.initials: MD
authors.lastname: Posadas
authors.forename: Gilda C
authors.initials: GC
authors.lastname: Revelant
authors.forename: Darío O
authors.initials: DO
authors.lastname: Marinozzi
authors.forename: Verónica B
authors.initials: VB
authors.lastname: Labourdette
authors.forename: María I
authors.initials: MI
authors.lastname: Zingale
authors.forename: María R
authors.initials: MR
authors.lastname: Venezia
mesh_terms: D000818:Animals; D001835:Body Weight / Q000502:physiology; D002119:Calcium Carbonate / Q000008:administration & dosage* / Q000737:chemistry; D002136:Calcium, Dietary / Q000008:administration & dosage* / Q000097:blood; D002784:Cholesterol / Q000097:blood; D005243:Feces / Q000737:chemistry; D008055:Lipids / Q000097:blood; D008099:Liver / Q000737:chemistry; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000178:diet therapy*; D008892:Milk / Q000737:chemistry*; D009765:Obesity / Q000097:blood*; D011897:Random Allocation; D051381:Rats; D015430:Weight Gain
chemical_list: D002136:Calcium, Dietary; D008055:Lipids; D002784:Cholesterol; D002119:Calcium Carbonate
keywords: calcium; milk; spontaneously obese rats