title: Clinically relevant determinants of body composition, function and nutritional status as mortality predictors in lung cancer patients.
abstract: Lung cancer belongs to the type of tumors with a relatively high frequency of malnutrition, sarcopenia and cachexia, severe metabolic syndromes related to impairment of physical function and quality of life, resistance to therapy and short survival. Inexpensive and accessible methods of evaluating changes in body composition, physical function and nutrition status are for this reason of great importance for clinical practice to enable the early identification, monitoring, preventing and treatment of these nutritional deficiencies. This could lead to improved outcomes in the quality of life, physical performance and survival of patients with lung cancer. The aim of this article is to summarize the recent knowledge for the use of such methods, their predictability for patient outcomes and an association with other clinically relevant parameters, specifically with lung cancer patients, because such an article collectively describing their practical application in clinical practice is lacking. The interest of this article is in the use of anthropometry, handgrip dynamometry, bioelectrical impedance analysis derived phase angle and nutritional screening questionnaires in lung cancer patients.
authors.affiliation: Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic; Department of Research and Development, University Hospital, Hradec Kralove, Czech Republic. Electronic address: kovarikm@faf.cuni.cz.
authors.forename: Miroslav
authors.initials: M
authors.lastname: Kovarik
authors.affiliation: Department of Biological and Medical Sciences, Faculty of Pharmacy, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic; Department of Research and Development, University Hospital, Hradec Kralove, Czech Republic.
authors.forename: Miloslav
authors.initials: M
authors.lastname: Hronek
authors.affiliation: Department of Research and Development, University Hospital, Hradec Kralove, Czech Republic.
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Zadak
mesh_terms: D000886:Anthropometry; D001823:Body Composition; D017097:Electric Impedance; D018737:Hand Strength; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000401:mortality; D009749:Nutrition Surveys; D009752:Nutritional Status; D011379:Prognosis; D011795:Surveys and Questionnaires
keywords: Anthropometry; Cachexia; Handgrip dynamometry; Lung cancer; Nutritional screening questionnaires; Outcome prediction; Phase angle; Sarcopenia