title: Central effects of camphor on GnRH and sexual hormones in male rat.
abstract: In Persian traditional medicine is believed that camphor (a crystalline ketone obtained from cinnamomum camphora) is a suppressor of sexual behaviors. This study examined the central effects of camphor on sexual hormones (LH, FSH and testosterone) and GnRH plasma levels in male rat. Male Wistar rats weighing 250-260gr were selected and divided into control (no treatment), sham (ICV injection of EtOH 10%) and treatment (ICV injection of camphor in three doses 4, 20, 40 µg/ 10µl in alcohol) groups. The serum samples were used for assaying of GnRH, LH, FSH and testosterone. There were no significant differences in the levels of hormones between the groups of study. Despite the central administration of camphor in hypothalamus - pituitary - gonad (HPG) axis, no significant differences were seen in sex hormone`s levels compared to the control. With this finding, it can be concluded that camphor may not effectively handle the axis via central pathway. These data recommend further studies of camphor on the HPG axis.
authors.affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. ; Department of Physiology and Pharmacology, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Sima
authors.initials: S
authors.lastname: Shahabi
authors.affiliation: Fatemeh Zahra Fertility and Infertility Reproductive Health Research Center, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Seyed Gholam Ali
authors.initials: SG
authors.lastname: Jorsaraei
authors.affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. ; Department of Physiology and Pharmacology, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Moghadamnia
authors.affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. ; Department of Physiology and Pharmacology, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ebrahim
authors.initials: E
authors.lastname: Zabihi
authors.affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
authors.forename: Seyed Mohsen
authors.initials: SM
authors.lastname: Aghajanpour
authors.affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
authors.forename: Seyedeh Narges
authors.initials: SN
authors.lastname: Mousavi Kani
authors.affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.
authors.forename: Roghieh
authors.initials: R
authors.lastname: Pourbagher
authors.affiliation: Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Seyed Ahmad
authors.initials: SA
authors.lastname: Hosseini
authors.affiliation: Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Esmaili
authors.affiliation: Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Ali Asghar
authors.initials: AA
authors.lastname: Yoonesi
authors.affiliation: Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Amin
authors.initials: A
authors.lastname: Zarghami
authors.affiliation: Student Research Committee, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Farid
authors.initials: F
authors.lastname: Alinezhad
keywords: Camphor; GnRH; Hypothalamus - Pituitary - Gonad (H-P-G) Axis