title: Lower leg compartment syndrome in neurofibromatosis 1 patient with plexiform neurofibrom: a case report of aneurysm rupture.
abstract: A 37-year-old woman with neurofibromatosis type 1 was referred for a rapidly growing plexiform neurofibroma of the left lower leg, acute serious pain, and leg palsy because of concern for malignant transformation of the tumor. Contrast-enhanced computed tomography confirmed a rupture of anterior tibial artery aneurysm, resulting in both anterior and posterior compartment syndrome in her left leg. Arterial involvement in neurofibromatosis is a well known; however, rupture of peripheral arteries is exceptional. Moreover, coexistence with plexiform neurofibroma occasionally delays the diagnosis with suspicion of malignant transformation without awareness of a vascular rupture.
authors.affiliation: Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address: ynishida@med.nagoya-u.ac.jp.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishida
authors.affiliation: Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tsukushi
authors.affiliation: Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Urakawa
authors.affiliation: Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Eisuke
authors.initials: E
authors.lastname: Arai
authors.affiliation: Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Kozawa
authors.affiliation: Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Ishiguro
mesh_terms: D000328:Adult; D000671:Amputation, Surgical; D017542:Aneurysm, Ruptured / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D001706:Biopsy; D003161:Compartment Syndromes / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D018318:Neurofibroma, Plexiform / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D016909:Tibial Arteries / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome