title: Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors.
abstract: MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.
authors.affiliation: 1.NIAID, NIH, Bldg. 33, Bethesda, MD 20892, USA. jyewdell@niaid.nih.gov.
authors.forename: Luis C
authors.initials: LC
authors.lastname: Antón
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Yewdell
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D056892:Mediator Complex; D015166:Monitoring, Immunologic; D009369:Neoplasms / Q000276:immunology*; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000276:immunology*
chemical_list: C113182:DRIP, VDR interacting protein complex; D015395:Histocompatibility Antigens Class I; D056892:Mediator Complex
keywords: antigen processing; compartmentalization; cotranslational degradation; nuclear translation; ribosome; translation