title: Aberrant BLID expression is associated with breast cancer progression.
abstract: In our previous study, we have found that BH3-like motif containing, cell death inducer (BLID) was a tumor suppressor in breast cancer, and its downregulation was correlated with both poor disease-free and overall survival. In the present study, we aimed to explore the possible role of BLID in breast cancer progression. We found that BLID was strongly expressed in all normal breast tissues, and it became lower and wreaker gradually in the progression from normal, UDH (usual ductal hyperplasia), ADH (atypical ductal hyperplasia), and DCIS (ductal carcinoma in situ) to breast cancer. Statistical analysis demonstrated significant different BLID expressions between proliferative and cancerous breast lesions. Our data suggested that loss of BLID may contribute to the progression of intraductal proliferation lesions to breast cancer. Our finding gives a new clue that BLID might be a potential indicator for progression of breast cancer in the future.
authors.affiliation: Department of Breast Surgery, Qilu Hospital, Shandong University, Wenhua Xi Road No.107, Jinan, 250012, People's Republic of China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Su
authors.forename: Xianqiang
authors.initials: X
authors.lastname: Liu
authors.forename: Xiangnan
authors.initials: X
authors.lastname: Kong
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhang
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D051017:Apoptosis Regulatory Proteins / Q000032:analysis / Q000502:physiology*; D001943:Breast Neoplasms / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged
chemical_list: D051017:Apoptosis Regulatory Proteins; C118024:BLID protein, human