title: The ancient microbial RIO kinases.
abstract: The RIO kinases existed before the split between Archaea and Eubacteria and are essential in eukaryotes. Although much has been elucidated in the past few years regarding the function of these proteins in eukaryotes, questions remain about their role in prokaryotes. Comparison of structure and sequence suggests that the ancient RIO kinases may have similar functional properties in prokaryotes as they do in eukaryotes. The conservation of charge distribution, functional residues, and overall structure supports a role for these proteins in ribosome interactions, as is their purpose in eukaryotes. However, a lack of study in this area has left little direct evidence in support of this function.
authors.affiliation: From the Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 and the University of Maryland Greenebaum Cancer Center, Baltimore, Maryland 21201.
authors.forename: Nicole A
authors.initials: NA
authors.lastname: LaRonde
mesh_terms: D001419:Bacteria / Q000201:enzymology* / Q000235:genetics; D019143:Evolution, Molecular; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
chemical_list: D017346:Protein Serine-Threonine Kinases
keywords: ATPases; Archaeal Protein Kinases; Bacterial Protein Kinases; Prokaryotic Protein Kinases; RIO Kinase; Ribosomal RNA Processing; Ribosome Assembly; Serine/Threonine Protein Kinase