title: Clinical features of 705 Borrelia burgdorferi seropositive patients in an endemic area of northern Italy.
abstract: BACKGROUND
  Lyme Borreliosis is a multisystemic infection caused by spirochetes of Borrelia burgdorferi sensu lato complex. The features of Lyme Borreliosis may differ in the various geographical areas, primarily between the manifestations found in America and those found in Europe and Asia.
  
  
  OBJECTIVE
  to describe the clinical features of Lyme Borreliosis in an endemic geographic area such as Friuli-Venezia Giulia in the Northeastern part of Italy.
  
  
  METHODS
  The medical records of patients resulted seropositive for Borrelia burgdorferi have been retrospectively recorded and analyzed.
  
  
  RESULTS
  Seven hundred and five patients met the inclusion criteria, 363 males and 342 females. Erythema migrans was the most common manifestation, detected in 437 patients. Other classical cutaneous manifestations included 58 cases of multiple erythema migrans, 7 lymphadenosis benigna cutis, and 18 acrodermatitis chronica atrophicans. The musculoskeletal system was involved in 511 patients. Four hundred and sixty patients presented a neurological involvement. Flu-like symptoms preceded or accompanied or were the only clinical feature in 119 patients.
  
  
  CONCLUSIONS
  The manifestations of Lyme borreliosis recorded in this study are similar to the ones of other endemic areas in Europe, even if there are some peculiar features which are different from those reported in Northern Europe and in the USA.
authors.affiliation: Department of Clinical and Experimental Pathology and Medicine, Institute of Dermatology, University of Udine School of Medicin, Ospedale "San Michele," Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, Italy.
authors.forename: Giuseppe
authors.identifier: 0000-0002-2392-9504
authors.initials: G
authors.lastname: Stinco
authors.affiliation: Clinical Laboratory and Microbiology Department, Hospital of San Daniele del Friuli, San Daniele, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Ruscio
authors.affiliation: Department of Clinical and Experimental Pathology and Medicine, Institute of Dermatology, University of Udine School of Medicin, Ospedale "San Michele," Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, Italy.
authors.forename: Serena
authors.identifier: 0000-0002-0618-3966
authors.initials: S
authors.lastname: Bergamo
authors.affiliation: Department of Clinical and Experimental Pathology and Medicine, Institute of Dermatology, University of Udine School of Medicin, Ospedale "San Michele," Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Trotter
authors.affiliation: Department of Clinical and Experimental Pathology and Medicine, Institute of Dermatology, University of Udine School of Medicin, Ospedale "San Michele," Piazza Rodolone 1, Gemona del Friuli, 33013 Udine, Italy.
authors.forename: Pasquale
authors.identifier: 0000-0003-2541-3576
authors.initials: P
authors.lastname: Patrone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D025065:Borrelia burgdorferi; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008193:Lyme Disease / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D055815:Young Adult