title: Endothelial function is associated with myocardial diastolic function in women with systemic lupus erythematosus.
abstract: Endothelial dysfunction is associated with traditional and systemic lupus erythematosus (SLE)-specific risk factors, and early data suggest reversibility of endothelial dysfunction with therapy. The clinical relevance of endothelial function assessment has been limited by the lack of studies, demonstrating its prognostic significance and impact on early myocardial function. Therefore, we aimed to determine the association between endothelial and myocardial diastolic function in SLE women. Women with SLE and no coronary artery disease were prospectively recruited and underwent radionuclide myocardial perfusion imaging (MPI) (Jetstream, Philips, the Netherlands) to exclude subclinical myocardial ischemia. Cardiac and vascular functions were assessed in all patients (Alpha 10, Aloka, Tokyo). Diastolic function was assessed using pulse wave early (E) and late mitral blood inflow and myocardial tissue Doppler (mean of medial and lateral annulus e') velocities. Endothelial function was measured using brachial artery flow-mediated vasodilatation (FMD%). Univariate and multivariate linear regressions were used to assess the association between FMD% and myocardial diastolic function, adjusting for potential confounders. Thirty-eight patients without detectable myocardial ischemia on MPI were studied (mean age 44 ± 10 years; mean disease duration 14 ± 6 years). About 61 % of patients had normal diastolic function (E/e' ≤ 8), and 5 % of patients had definite diastolic dysfunction with E/e' > 13 (mean 7.1 ± 2.9). FMD% was associated with E/e' (regression coefficient β = -0.35; 95 % CI -0.62 to -0.08; p = 0.01) independent of systolic blood pressure, age, and SLICC/ACR Damage Index.
authors.affiliation: Department of Cardiovascular Medicine, National Heart Center Singapore, 17 Third Hospital Avenue, Mistri Wing, Singapore, 168752, Singapore, cchin03m@gmail.com.
authors.forename: Calvin W L
authors.initials: CW
authors.lastname: Chin
authors.forename: Chee-Yang
authors.initials: CY
authors.lastname: Chin
authors.forename: Marie X R
authors.initials: MX
authors.lastname: Ng
authors.forename: Thu-Thao
authors.initials: TT
authors.lastname: Le
authors.forename: Fei-Qiong
authors.initials: FQ
authors.lastname: Huang
authors.forename: Kok-Yong
authors.initials: KY
authors.lastname: Fong
authors.forename: Julian
authors.initials: J
authors.lastname: Thumboo
authors.forename: Ru-San
authors.initials: RS
authors.lastname: Tan
mesh_terms: D000328:Adult; D003971:Diastole; D018619:Echocardiography, Doppler, Pulsed; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006331:Heart Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D016014:Linear Models; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008875:Middle Aged; D008943:Mitral Valve / Q000503:physiopathology; D015999:Multivariate Analysis; D055414:Myocardial Perfusion Imaging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012307:Risk Factors; D014664:Vasodilation; D016277:Ventricular Function, Left; D055815:Young Adult