title: Network-wide dysregulation of calcium homeostasis in Alzheimer's disease.
abstract: Dysregulation of intracellular Ca(2+) homeostasis has been proposed as a common proximal cause of neural dysfunction during aging and Alzheimer's disease (AD). In this context, aberrant Ca(2+) signaling has been viewed as a neuronal phenomenon mostly related to the dysfunction of intracellular Ca(2+) stores. However, recent data suggest that, in AD, Ca(2+) dyshomeostasis is not restricted to neurons but represents a global phenomenon affecting virtually all cells in the brain. AD-related aberrant Ca(2+) signaling in astrocytes and microglia, which is activated during the disease, probably contributes profoundly to an inflammatory response that, in turn, impacts neuronal Ca(2+) homeostasis and brain function. Based on recent data obtained in vivo and in vitro, we propose that bidirectional interactions between the inflammatory responses of glial cells and aberrant Ca(2+) signaling represent a vicious cycle accelerating disease progression.
authors.affiliation: Institute of Physiology II, Eberhard Karls University of Tübingen, Keplerstrasse 15, 72074, Tübingen, Germany.
authors.forename: Bianca
authors.initials: B
authors.lastname: Brawek
authors.forename: Olga
authors.initials: O
authors.lastname: Garaschuk
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D001253:Astrocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002118:Calcium / Q000276:immunology / Q000378:metabolism; D020013:Calcium Signaling; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D017628:Microglia / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: D002118:Calcium