title: Efficacy of Cinnamomum cassia Blume. in age induced sexual dysfunction of rats.
abstract: OBJECTIVE
  Cinnamomum cassia has been suggested in Ayurveda for the management of sexual dysfunction. This research work was conducted to shed some light on the mechanism of action of the extract, and evaluate the efficacy of its methanol extract in age induced sexual dysfunction in male Wistar rats. Secondary objective of the project was to study the effect of treatment on sperm parameters and smooth muscle:collagen level in rat penile tissue.
  
  
  METHODS
  Young and aged male rats were treated with methanol extract of Cinnamomum cassia at a dose of 100 mg/kg and sexual behavior was observed on 28th day in presence of female rats in estrous phase. Sildenafil was used as standard medicine. Effect of treatment was studied on epididymal sperm parameters, and Massons trichrome staining of rat penile tissues was performed to know the level of smooth muscle:collagen.
  
  
  RESULTS
  The treatment significantly increased sexual function in aged rats that had decreased in comparison to young rats, but did not have any significant effect on sperm count, live and defective sperm percentage. However, treatment induced an increase in smooth muscle level and a decrease in collagen level in the aged rat penile tissue in comparison to that of age matched control.
  
  
  CONCLUSIONS
  Based on our studies, we found that Cinnamomum cassia extract was effective in management of sexual dysfunction in aged rats and hence we propose a possible mechanism of action for Cinnamomum cassia which could be responsible for restoring sexual activity in aged rat.
authors.affiliation: Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore 560027, India.
authors.forename: Sumanta Kumar
authors.initials: SK
authors.lastname: Goswami
authors.affiliation: Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore 560027, India.
authors.forename: Mohammed Naseeruddin
authors.initials: MN
authors.lastname: Inamdar
authors.affiliation: Bioassay Lab, Research and Development Centre, Natural Remedies Pvt. Ltd., Bangalore 560100, India.
authors.forename: Rohitash
authors.initials: R
authors.lastname: Jamwal
authors.affiliation: Bioassay Lab, Research and Development Centre, Natural Remedies Pvt. Ltd., Bangalore 560100, India.
authors.forename: Shekhar
authors.initials: S
authors.lastname: Dethe
keywords: Aged rat; Cinnamomum cassia; Corpus cavernosum; Sexual dysfunction; Sperm parameters