title: Lipid presentation by human CD1 molecules and the diverse T cell populations that respond to them.
abstract: CD1 molecules bind and present lipid-based antigens to T cells. Humans express both Group 1 (CD1a, CD1b and CD1c) and Group 2 (CD1d) CD1 molecules with nonredundant functions in the human immune response. Studies of Group 1 CD1 molecules and the T cells that respond to them have lagged behind Group 2 due to the lack of a suitable model system. However, recent work has thrust the Group 1 CD1s into the limelight, revealing their importance in tissue surveillance and microbial defense. Here I review recent advances in Group 1 CD1 lipid presentation, the T cell populations that respond to them and the role of CD1 molecules in engagement of human γδ T cells.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Chicago, 929 East 57th Street, GCIS W236, Chicago, IL 60637, United States. Electronic address: ejadams@uchicago.edu.
authors.forename: Erin J
authors.initials: EJ
authors.lastname: Adams
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000235:genetics / Q000276:immunology*; D018949:Antigens, CD1 / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D055610:Antigens, CD1d / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation / Q000276:immunology; D006023:Glycoproteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008053:Lipid Mobilization / Q000235:genetics / Q000276:immunology*; D011485:Protein Binding / Q000235:genetics / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000145:classification / Q000276:immunology* / Q000378:metabolism*
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; C437944:CD1C protein, human; C526877:CD1D protein, human; C419393:CD1a antigen; C419394:CD1b antigen; D006023:Glycoproteins