title: Pilot clinical study of boron neutron capture therapy for recurrent hepatic cancer involving the intra-arterial injection of a (10)BSH-containing WOW emulsion.
abstract: A 63-year-old man with multiple HCC in his left liver lobe was enrolled as the first patient in a pilot study of boron neutron capture therapy (BNCT) involving the selective intra-arterial infusion of a (10)BSH-containing water-in-oil-in-water emulsion ((10)BSH-WOW). The size of the tumorous region remained stable during the 3 months after the BNCT. No adverse effects of the BNCT were observed. The present results show that (10)BSH-WOW can be used as novel intra-arterial boron carriers during BNCT for HCC.
authors.affiliation: Department of Innovative Cancer Therapeutics: Alpha particle and Immuno-therapeutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan; Department of Nuclear Engineering & Management, Graduate School of Engineering, The University of Tokyo, Japan; Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, Japan. Electronic address: yanagie@my-pharm.ac.jp.
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yanagie
authors.affiliation: Department of Surgery, Kojin-kai Medical City East Hospital, Miyazaki, Japan.
authors.forename: Syushi
authors.initials: S
authors.lastname: Higashi
authors.affiliation: Department of Surgery, Kojin-kai Medical City East Hospital, Miyazaki, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Seguchi
authors.affiliation: Department of Innovative Cancer Therapeutics: Alpha particle and Immuno-therapeutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan; Kyushu Medical & Industrial Sources Foundation, Miyazaki, Japan; Department of Radiology, Miyakonojyo Metropolitan Hospital, Miyazaki, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ikushima
authors.affiliation: SPG Techno Ltd. Co., Miyazaki, Japan.
authors.forename: Mituteru
authors.initials: M
authors.lastname: Fujihara
authors.affiliation: Department of Surgery, Keiaikai Hoyo Hospital, Iwate, Japan.
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Nonaka
authors.affiliation: Department of Radiology, Shin-Yamate Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Oyama
authors.affiliation: Department of Surgery, Shin-Yamate Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
authors.forename: Syoji
authors.initials: S
authors.lastname: Maruyama
authors.affiliation: Department of Surgery, Shin-Yamate Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Hatae
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Masunaga
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kinashi
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanaka
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Natsuko
authors.initials: N
authors.lastname: Kondo
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Narabayashi
authors.affiliation: Department of Innovative Cancer Therapeutics: Alpha particle and Immuno-therapeutics, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kajiyama
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Maruhashi
authors.affiliation: Research Reactor Institute, Kyoto University, Osaka, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Ono
authors.affiliation: Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, Japan; Department of Respiratory Surgery, The University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Nakajima
authors.affiliation: Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, Japan; Department of Cardiac Surgery, The University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Ono
authors.affiliation: Department of Nuclear Engineering & Management, Graduate School of Engineering, The University of Tokyo, Japan; Cooperative Unit of Medicine & Engineering, The University of Tokyo Hospital, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.affiliation: Department of Surgery, Shin-Yamate Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan.
authors.forename: Masazumi
authors.initials: M
authors.lastname: Eriguchi
mesh_terms: D001894:Borohydrides / Q000008:administration & dosage* / Q000737:chemistry; D016754:Boron Neutron Capture Therapy / Q000379:methods*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000532:radiotherapy*; D004655:Emulsions / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000532:radiotherapy*; D009821:Oils / Q000737:chemistry; D010865:Pilot Projects; D013438:Sulfhydryl Compounds / Q000008:administration & dosage* / Q000737:chemistry; D016896:Treatment Outcome; D014867:Water / Q000737:chemistry
chemical_list: D001894:Borohydrides; D004655:Emulsions; D009821:Oils; D013438:Sulfhydryl Compounds; D014867:Water; C014651:mercaptoundecahydrododecaborate
keywords: Boron neutron capture therapy; Hepatocellular carcinoma; Intra-arterial injection; Water-in-oil-in-water emulsion