title: Seven functional polymorphisms in the CETP gene and myocardial infarction risk: a meta-analysis and meta-regression.
abstract: OBJECTIVE
  This meta-analysis aims to evaluate the relationships between seven functional polymorphisms in the CETP gene and myocardial infarction (MI) risk.
  
  
  METHODS
  The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before March 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.0 software.
  
  
  RESULTS
  Nine case-control studies with a total 8,623 MI cases and 8,564 healthy subjects met the inclusion criteria. The results of our meta-analysis suggested that CETP rs708272 (C>T) polymorphism might be correlated with an increased risk of MI, especially among Caucasians. Furthermore, we observed that CETP rs1800775 (C>A) polymorphism might increase the risk of MI. Nevertheless, no similar findings were found for CETP rs5882 (A>G), rs2303790 (A>G), rs1800776 (C>A), rs12149545 (G>A), and rs4783961 (G>A) polymorphisms.
  
  
  CONCLUSIONS
  The current meta-analysis suggests that CETP rs708272 (C>T) and rs1800775 (C>A) polymorphisms may contribute to MI susceptibility, especially among Caucasians. Thus, CETP rs708272 and rs1800775 polymorphisms may be promising and potential biomarkers for early diagnosis of MI.
authors.affiliation: Department of Cardiology, the Fourth Affiliated Hospital of China Medical University, Shenyang, P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Cardiology, the Fourth Affiliated Hospital of China Medical University, Shenyang, P.R. China.
authors.forename: Shao-Bo
authors.initials: SB
authors.lastname: Zhou
authors.affiliation: Department of Cardiology, the Fourth Affiliated Hospital of China Medical University, Shenyang, P.R. China.
authors.forename: Li-Jie
authors.initials: LJ
authors.lastname: Wang
authors.affiliation: Department of Cardiology, the Fourth Affiliated Hospital of China Medical University, Shenyang, P.R. China.
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Lei
authors.affiliation: Department of Cardiology, the Fourth Affiliated Hospital of China Medical University, Shenyang, P.R. China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Cardiology, the Fourth Affiliated Hospital of China Medical University, Shenyang, P.R. China.
authors.forename: Chi
authors.initials: C
authors.lastname: Miao
authors.affiliation: Department of Cardiology, the Fourth Affiliated Hospital of China Medical University, Shenyang, P.R. China.
authors.forename: Yuan-Zhe
authors.initials: YZ
authors.lastname: Jin
mesh_terms: D000483:Alleles; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D015331:Cohort Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D005819:Genetic Markers