title: Examining relations between alpha power as well as anterior cingulate cortex-localized theta activity and response to single or dual antidepressant pharmacotherapies.
abstract: Electrocortical indices may be useful in predicting antidepressant response. Greater pretreatment alpha power and high rostral anterior cingulate cortex (rACC) theta activity tend to index a favorable outcome. The predictive utility of alpha power asymmetry has been under-explored. Baseline alpha2 (10.5-13.0 Hz) power/asymmetry, rACC theta2 (6.0-8.0 Hz) activity and early (one week) changes in these measures were assessed in relation to antidepressant response by week 12 to three treatment regimens (escitalopram (ESC) + bupropion (BUP), ESC or BUP) in patients with major depressive disorder (N=51). No treatment differences in response existed at week 12. Overall, treatment responders exhibited high, and non-responders low, frontal baseline alpha2 power. Frontal alpha2 power weakly discriminated responders/non-responders overall while posterior alpha2 power and BA25-localized theta2 activity strongly discriminated ESC responders/non-responders. No associations with alpha2 asymmetry and response emerged. BUP responders exhibited high, and BUP non-responders low, baseline rACC theta2 activity. Greater early decreases in rACC theta2 activity existed in ESC+BUP non-responders versus ESC+BUP responders. BUP responders exhibited greater rACC theta2 activity decreases than ESC responders. These preliminary results indicate that baseline and early changes in alpha2 and rACC theta2 activity associate with response and have implications for tailoring antidepressant treatments.
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada Mathison Centre for Mental Health Research and Education, Department of Psychiatry, University of Calgary, Calgary, AB, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada Alberta Children's Hospital Research Institute, University of Calgary, AB, Calgary, Canada jaworskn@ucalgary.ca.
authors.forename: Natalia
authors.initials: N
authors.lastname: Jaworska
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.
authors.forename: Claude
authors.initials: C
authors.lastname: Blondeau
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Tessier
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.
authors.forename: Sandhaya
authors.initials: S
authors.lastname: Norris
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.
authors.forename: Wendy
authors.initials: W
authors.lastname: Fusee
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Blier
authors.affiliation: University of Ottawa Institute of Mental Health Research, Ottawa, ON, Canada.
authors.forename: Verner
authors.initials: V
authors.lastname: Knott
mesh_terms: D000328:Adult; D000513:Alpha Rhythm / Q000187:drug effects*; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000627:therapeutic use*; D001931:Brain Mapping / Q000379:methods; D016642:Bupropion / Q000009:adverse effects / Q000627:therapeutic use*; D015283:Citalopram / Q000009:adverse effects / Q000627:therapeutic use*; D003863:Depression / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004585:Electrooculography; D005260:Female; D006179:Gyrus Cinguli / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013826:Theta Rhythm / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D015283:Citalopram
keywords: Depression; alpha2; alpha2 asymmetry; anterior cingulate cortex; bupropion; combination treatment; escitalopram; standardized low-resolution brain electromagnetic tomography (sLORETA); theta2