title: Glucocorticoids and renal Na+ transport: implications for hypertension and salt sensitivity.
abstract: The clinical manifestations of glucocorticoid excess include central obesity, hyperglycaemia, dyslipidaemia, electrolyte abnormalities and hypertension. A century on from Cushing's original case study, these cardinal features are prevalent in industrialized nations. Hypertension is the major modifiable risk factor for cardiovascular and renal disease and reflects underlying abnormalities of Na(+) homeostasis. Aldosterone is a master regulator of renal Na(+) transport but here we argue that glucocorticoids are also influential, particularly during moderate excess. The hypothalamic-pituitary-adrenal axis can affect renal Na(+) homeostasis on multiple levels, systemically by increasing mineralocorticoid synthesis and locally by actions on both the mineralocorticoid and glucocorticoid receptors, both of which are expressed in the kidney. The kidney also expresses both of the 11β-hydroxysteroid dehydrogenase (11βHSD) enzymes. The intrarenal generation of active glucocorticoid by 11βHSD1 stimulates Na(+) reabsorption; failure to downregulate the enzyme during adaption to high dietary salt causes salt-sensitive hypertension. The deactivation of glucocorticoid by 11βHSD2 underpins the regulatory dominance for Na(+) transport of mineralocorticoids and defines the 'aldosterone-sensitive distal nephron'. In summary, glucocorticoids can stimulate renal transport processes conventionally attributed to the renin-angiotensin-aldosterone system. Importantly, Na(+) and volume homeostasis do not exert negative feedback on the hypothalamic-pituitary-adrenal axis. These actions are therefore clinically relevant and may contribute to the pathogenesis of hypertension in conditions associated with elevated glucocorticoid levels, such as the metabolic syndrome and chronic stress.
authors.affiliation: University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. matthew.bailey@ed.ac.uk.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Hunter
authors.forename: Jessica R
authors.initials: JR
authors.lastname: Ivy
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Bailey
mesh_terms: D000818:Animals; D005938:Glucocorticoids / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism*; D017136:Ion Transport; D007668:Kidney / Q000378:metabolism / Q000502:physiology*; D012084:Renin-Angiotensin System; D012964:Sodium / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D005938:Glucocorticoids; D012964:Sodium