title: [Comparative study on decoction and dissolution of crude and processed corni fructus].
abstract: To compare and study the decoction and dissolution of active constituents in crude and processed Corni Fructus. HPLC, the traditional Chinese medicine (TCM) decoction method and the dissolution methods were adopted to compare and study the decoction yield and dissolution rate of loganin and morroniside, active constituents in crude and processed Corni Fructus. The results showed that the content of active constituents loganin and morroniside in crude and processed Corni Fructus did not change significantly; compared with crude Corni Fructus, processed Corni Fructus (decoction) contained much higher loganin, with no obvious change in morroniside; compared with crude Corni Fructus, processed Corni Fructus (extracts) showed no significant difference in loganin dissolution, but notable increase in morroniside dissolution in intestinal fluid; in gastric fluid, processed Corni Fructus showed significant increase in loganin and morroniside dissolutions. However, in comprehensive consideration of the decoction dose in clinical administration, and calculated on the basis of the formula of the decoction yield x dissolution rate = decoction-dissolution product, it showed increase in the decoction-dissolution products of both of the active constituents loganin and morroniside, with significant difference. This suggested that processed Corni Fructus is superior to crude Corni Fructus in clinical application. In this article, we proposed to compare the changes in decoction and dissolution of active constituents in crude and processed Corni Fructus, study the decoction-dissolution product, and then apply it in the quality evaluation of crude and processed Corni Fructus.
authors.affiliation: Technical Center of Traditional Chinese Medicine Processing, Zhejiang Chinese Medical University, Hangzhou 310053, China. 283222761@qq.com
authors.forename: Han-Yu
authors.initials: HY
authors.lastname: Zhou
authors.affiliation: Technical Center of Traditional Chinese Medicine Processing, Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors.forename: Pei-Pei
authors.initials: PP
authors.lastname: Yang
authors.affiliation: Technical Center of Traditional Chinese Medicine Processing, Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Cong
authors.affiliation: Technical Center of Traditional Chinese Medicine Processing, Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors.forename: Cheng-Rong
authors.initials: CR
authors.lastname: Zhang
authors.affiliation: Technical Center of Traditional Chinese Medicine Processing, Zhejiang Chinese Medical University, Hangzhou 310053, China.
authors.forename: Bao-Chang
authors.initials: BC
authors.lastname: Cai
mesh_terms: D002851:Chromatography, High Pressure Liquid; D029768:Cornus / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000493:pharmacokinetics; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008954:Models, Biological; D012995:Solubility
chemical_list: D004365:Drugs, Chinese Herbal