title: Cellular Response to Ionizing Radiation: A MicroRNA Story.
abstract: MicroRNAs (miRNAs) represent a class of small non-coding RNA molecules that regulate gene expression at the post-transcriptional level. They play a crucial role in diverse cellular pathways. Ionizing radiation (IR) is one of the most important treatment protocols for patients that suffer from cancer and affects directly or indirectly cellular integration. Recently it has been discovered that microRNA-mediated gene regulation interferes with radio-related pathways in ionizing radiation. Here, we review the recent discoveries about miRNAs in cellular response to IR. Thoroughly understanding the mechanism of miRNAs in radiation response, it will be possible to design new strategies for improving radiotherapy efficiency and ultimately cancer treatment.
authors.affiliation: Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Halimi
authors.affiliation: Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
authors.forename: S Mohsen
authors.initials: SM
authors.lastname: Asghari
authors.affiliation: Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
authors.forename: Reyhaneh
authors.initials: R
authors.lastname: Sariri
authors.affiliation: Department of Radiation oncology, Babol University of Medical Sciences, Babol, Iran.
authors.forename: Dariush
authors.initials: D
authors.lastname: Moslemi
authors.affiliation: Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran. ; Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol, Iran .
authors.forename: Hadi
authors.initials: H
authors.lastname: Parsian
keywords: Cellular response; ionizing radiation; microRNA