title: Preparation and characterization of poly(triallyl isocyanurate-co-trimethylolpropane triacrylate) monolith and its applications in the separation of small molecules by liquid chromatography.
abstract: A new polymeric monolith was prepared in stainless-steel column and fused-silica capillary, respectively, by atom transfer radical polymerization technique. In the polymerization, triallyl isocyanurate (TAIC) was used as the functional monomer; trimethylolpropane triacrylate (TMPTA) as the crosslinking agent; polyethylene glycol 200 and 1,2-propanediol as the co-porogens; carbon tetrachloride as the initiator and ferrous chloride as the catalyst. The conditions of polymerization were optimized. Morphology of the prepared poly(TAIC-co-TMPTA) monolith was investigated by scanning electron microscopy; pore properties were assayed by mercury porosimetry and nitrogen adsorption. The characterization indicated that the prepared reversed-phase monolith possessed uniform structure, good permeability and mechanical stability. The column was used as the stationary phase of reversed phase high performance liquid chromatography (RP-HPLC) and capillary liquid chromatography (CLC) to separate the mixture of aromatic compounds. The new column performed around 125,000 theoretical plates per meter. The column showed good reproducibility: the relative standard deviation values of the retention factor values for aromatic compounds were less than 1.52% (n=7, column-to-column).
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhong
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
authors.forename: Mengbei
authors.initials: M
authors.lastname: Hao
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
authors.forename: Ruo
authors.initials: R
authors.lastname: Li
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China.
authors.forename: Ligai
authors.initials: L
authors.lastname: Bai
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Baoding 071002, China; College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China. Electronic address: ygl@hbu.edu.cn.
authors.forename: Gengliang
authors.initials: G
authors.lastname: Yang
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D002853:Chromatography, Liquid; D056148:Chromatography, Reverse-Phase; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry; D058105:Polymerization; D015203:Reproducibility of Results; D014227:Triazines / Q000737:chemistry*
chemical_list: D000179:Acrylates; D014227:Triazines; C000589787:poly(triallyl isocyanurate-co-trimethylolpropane triacrylate); C480124:1,3,5-triallyl isocyanurate; D011092:Polyethylene Glycols; C027993:trimethylolpropane triacrylate
keywords: Capillary liquid chromatography (CLC); High performance liquid chromatography (HPLC); Poly(TAIC-co-TMPTA) monolith; Reversed-phase chromatography; Small molecules