title: Epidemiology and mortality of liver abscess in end-stage renal disease dialysis patients: Taiwan national cohort study.
abstract: OBJECTIVE
  To determine the incidence rates and mortality of liver abscess in ESRD patients on dialysis.
  
  
  METHODS
  Using Taiwan's National Health Insurance Research Database, we collected data from all ESRD patients who initiated dialysis between 2000 and 2006. Patients were followed until death, end of dialysis, or December 31, 2008. Predictors of liver abscess and mortality were identified using Cox models.
  
  
  RESULTS
  Of the 53,249 incident dialysis patients identified, 447 were diagnosed as having liver abscesses during the follow-up period (224/100,000 person-years). The cumulative incidence rate of liver abscess was 0.3%, 1.1%, and 1.5% at 1 year, 5 years, and 7 years, respectively. Elderly patients and patients on peritoneal dialysis had higher incidence rates. The baseline comorbidities of diabetes mellitus, polycystic kidney disease, malignancy, chronic liver disease, biliary tract disease, or alcoholism predicted development of liver abscess. Overall in-hospital mortality was 10.1%.
  
  
  CONCLUSIONS
  The incidence of liver abscess is high among ESRD dialysis patients. In addition to the well known risk factors of liver abscess, two other important risk factors, peritoneal dialysis and polycystic kidney disease, were found to predict liver abscess in ESRD dialysis patients.
authors.affiliation: Department of Internal Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Chon-Seng
authors.initials: CS
authors.lastname: Hong
authors.affiliation: Department of General Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Kun-Ming
authors.initials: KM
authors.lastname: Chung
authors.affiliation: Department of Orthopedics Medicine, Chi-Mei Medical Center, Taiwan.
authors.forename: Po-Chang
authors.initials: PC
authors.lastname: Huang
authors.affiliation: Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
authors.affiliation: Department of Neurology, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Yang
authors.affiliation: Department of Medical Research, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Chin-Chen
authors.initials: CC
authors.lastname: Chu
authors.affiliation: Department of Neurological Surgery, Chi-Mei Medical Center, Tainan, Taiwan.
authors.forename: Chung-Ching
authors.initials: CC
authors.lastname: Chio
authors.affiliation: Department of Pharmaceutical Science and Technology, Chung Hwa University of Medical Technology, Tainan, Taiwan.
authors.forename: Fu-Lin
authors.initials: FL
authors.lastname: Chang
authors.affiliation: Department of Nephrology, Chi-Mei Medical Center, Tainan, Taiwan ; Department of Food Nutrition, Chung Hwa University of Medical Technology, Tainan, Taiwan.
authors.forename: Chih-Chiang
authors.initials: CC
authors.lastname: Chien
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003710:Demography; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000401:mortality*; D008100:Liver Abscess / Q000150:complications* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000706:statistics & numerical data*; D012307:Risk Factors; D015996:Survival Rate; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult