title: Multigene families of immunoglobulin domain-containing innate immune receptors in zebrafish: deciphering the differences.
abstract: Five large multigene families encoding innate-type immune receptors that are comprised of immunoglobulin domains have been identified in bony fish, of which four do not possess definable mammalian orthologs. The members of some of the multigene families exhibit unusually extensive patterns of divergence and the individual family members demonstrate marked variation in interspecific comparisons. As a group, the gene families reveal striking differences in domain type and content, mechanisms of intracellular signaling, basic structural features, haplotype and allelic variation and ligand binding. The potential functional roles of these innate immune receptors, their relationships to immune genes in higher vertebrate species and the basis for their adaptive evolution are of broad interest. Ongoing investigations are expected to provide new insight into alternative mechanisms of immunity.
authors.affiliation: Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA.
authors.forename: Iván
authors.initials: I
authors.lastname: Rodríguez-Nunez
authors.affiliation: Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA.
authors.forename: Dustin J
authors.initials: DJ
authors.lastname: Wcisel
authors.affiliation: Department of Pediatrics, University of South Florida College of Medicine, USF/ACH Children's Research Institute, 140 7th Avenue South, St. Petersburg, FL 33701, USA; Department of Molecular Genetics, All Children's Hospital, 501 6th Avenue South, St. Petersburg, FL 33701, USA; H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
authors.forename: Gary W
authors.initials: GW
authors.lastname: Litman
authors.affiliation: Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA. Electronic address: Jeff_Yoder@ncsu.edu.
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Yoder
mesh_terms: D000818:Animals; D006239:Haplotypes; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D015027:Zebrafish / Q000235:genetics* / Q000276:immunology*; D029961:Zebrafish Proteins / Q000737:chemistry / Q000235:genetics* / Q000276:immunology
chemical_list: D011971:Receptors, Immunologic; D029961:Zebrafish Proteins
keywords: Diverse immunoglobulin domain containing proteins; Leukocyte immune-type receptors; Novel immune-type receptors; Novel immunoglobulin-like transcripts; Polymeric immunoglobulin receptor-like proteins