title: A convergent synthesis of the fully elaborated macrocyclic core of TMC-95A.
abstract: A concise and straightforward synthesis of the fully elaborated macrocyclic core of TMC-95A is reported. A highly efficient organocatalyzed aldolization between isatin and dihydroxyacetone derivatives and formation of the biaryl subunit with concomitant macrocyclization are the characteristic features of this synthesis.
authors.affiliation: Institut Lavoisier de Versailles, UMR CNRS 8180, Université de Versailles Saint-Quentin-en-Yvelines , 45, avenue des Etats-Unis, 78035 Versailles Cedex, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Coste
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bayle
authors.forename: Jérome
authors.initials: J
authors.lastname: Marrot
authors.forename: Gwilherm
authors.initials: G
authors.lastname: Evano
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D010456:Peptides, Cyclic; D011480:Protease Inhibitors; C408291:TMC-95A