title: Evaluation of graft-host interface after penetrating keratoplasty using anterior segment optical coherence tomography.
abstract: OBJECTIVE
  To evaluate the characteristics of the graft-host interface after penetrating keratoplasty (PKP) using anterior segment optical coherence tomography (AS-OCT).
  
  
  METHODS
  Forty-nine eyes of 49 patients with three different underlying diseases (corneal scar, 22 eyes; bullous keratopathy, 14 eyes; keratoconus, 13 eyes) who underwent PKP were retrospectively reviewed. AS-OCT was performed in all patients and wound profiles of the graft-host junctions were classified into well-apposed junction, gap, step, and protrusion. The correlations between clinical characteristics and wound profiles from the AS-OCT were analyzed.
  
  
  RESULTS
  A total of 392 graft-host junctions from 49 eyes were analyzed. Among them, 155 sections (39.5 %) had well-apposed junctions and 237 sections (60.5 %) had malapposed junctions. The most frequent type of malapposition was protrusion (117 sections, 39.9 %). When categorizing the eyes according to the most frequent alignment type among the 8 cross-sections, the alignment pattern showed significant differences between the preoperative diagnosis groups (P = 0.04). Spherical equivalent (P = 0.04) and keratometric astigmatism (P < 0.01) showed significant differences between the alignment groups. Graft-host thickness disparities showed significant correlations with keratometric astigmatism (r = 0.56, P < 0.01) and degree of graft oversize (r = 0.29, P = 0.04).
  
  
  CONCLUSIONS
  The alignment pattern of wound interface after PKP differed according to the clinical diagnosis before surgery and was significantly associated with spherical equivalent and keratometric astigmatism.
authors.affiliation: Department of Ophthalmology, Chonnam National University Medical School and Hospital, Center for Creative Biomedical Scientists at Chonnam National University, 8 Hakdong, Donggu, Gwangju, 501-757, Korea.
authors.forename: Mi Sun
authors.initials: MS
authors.lastname: Sung
authors.forename: Kyung Chul
authors.initials: KC
authors.lastname: Yoon
mesh_terms: D000328:Adult; D000368:Aged; D000869:Anterior Eye Segment / Q000473:pathology*; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000601:surgery*; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014019:Tissue Donors; D041623:Tomography, Optical Coherence; D066027:Transplant Recipients; D014945:Wound Healing