title: Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a nested case-control study.
abstract: BACKGROUND
  Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV₁ < LLN.
  
  
  METHODS
  Nested case-control study of WTC-exposed firefighters. Cases had FEV₁ < LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured.
  
  
  RESULTS
  LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV₁ < LLN in a multivariable model.
  
  
  CONCLUSIONS
  Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV₁ < LLN.
authors.affiliation: Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University , New York, NY , USA .
authors.forename: Jun
authors.initials: J
authors.lastname: Tsukiji
authors.forename: Soo Jung
authors.initials: SJ
authors.lastname: Cho
authors.forename: Ghislaine C
authors.initials: GC
authors.lastname: Echevarria
authors.forename: Sophia
authors.initials: S
authors.lastname: Kwon
authors.forename: Phillip
authors.initials: P
authors.lastname: Joseph
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Schenck
authors.forename: Bushra
authors.initials: B
authors.lastname: Naveed
authors.forename: David J
authors.initials: DJ
authors.lastname: Prezant
authors.forename: William N
authors.initials: WN
authors.lastname: Rom
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Schmidt
authors.forename: Michael D
authors.initials: MD
authors.lastname: Weiden
authors.forename: Anna
authors.initials: A
authors.lastname: Nolan
mesh_terms: D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D061388:Firefighters; D005541:Forced Expiratory Volume; D006801:Humans; D055370:Lung Injury / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D008246:Lysophospholipids / Q000097:blood*; D008875:Middle Aged; D016273:Occupational Exposure; D052638:Particulate Matter / Q000633:toxicity*; D012306:Risk; D047851:September 11 Terrorist Attacks
chemical_list: C505693:APOA1 protein, human; D016632:Apolipoprotein A-I; D015415:Biomarkers; D008246:Lysophospholipids; D052638:Particulate Matter; C032881:lysophosphatidic acid