title: Synthesis of 4'-(2-ferrocenyl)-2,2':6'2''-terpyridine: characterization and antiprotozoal activity of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) complexes.
abstract: A terpyridine ligand Fctpy was reacted with divalent metals (Cu, Co, Mn, Ni and Zn), yielding five complexes of general formula [Metal(Fctpy)2][PF6]2. The structure of Fctpy was determined by single crystal X-ray diffraction studies. The complexes characterized using various spectroscopic techniques suggested an octahedral geometry around the central metal ion. These complexes were screened for their antiamoebic, trypanocidal and antimalarial activities. It was found that, complexes 2 and 3 showed better IC50 values than metronidazole against HM1:IMSS strain of Entamoeba histolytica. A substantial parasitic inhibition was not observed for the trypanocidal activity. However, for the erythrocytic stage of W2 strain of Plasmodium falciparum, the complexes inhibited β-hematin formation. At the concentration of 10 μg/mL, these complexes did not display toxicity.
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India.
authors.forename: Annu
authors.initials: A
authors.lastname: Juneja
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40296-710 Salvador, BA, Brazil.
authors.forename: Tais Soares
authors.initials: TS
authors.lastname: Macedo
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40296-710 Salvador, BA, Brazil; Centro de Biotecnologia e Terapia Celular, Hospital São Rafael. Av. São Rafael, 2152, São Marcos, 41253-190 Salvador, BA, Brazil.
authors.forename: Diogo Rodrigo
authors.initials: DR
authors.lastname: Magalhaes Moreira
authors.affiliation: Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz, Rua Waldemar Falcão, 121, Candeal, 40296-710 Salvador, BA, Brazil; Centro de Biotecnologia e Terapia Celular, Hospital São Rafael. Av. São Rafael, 2152, São Marcos, 41253-190 Salvador, BA, Brazil.
authors.forename: Milena Botelho
authors.initials: MB
authors.lastname: Pereira Soares
authors.affiliation: Department of Pharmaceutical Sciences, Centre for Health Sciences, Federal University of Pernambuco, 50740-520 Recife, PE, Brazil.
authors.forename: Ana Cristina
authors.initials: AC
authors.lastname: Lima Leite
authors.affiliation: Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, 50670-420 Recife, PE, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Kelle de Andrade Lemoine Neves
authors.affiliation: Departamento de Imunologia, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, 50670-420 Recife, PE, Brazil.
authors.forename: Valeria Rego
authors.initials: VR
authors.lastname: Alves Pereira
authors.affiliation: Departamento de Química Fundamental, Universidade da Coruña, Campus da Zapateira s/n, 15071 A Coruña, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Avecilla
authors.affiliation: Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi 110025, India. Electronic address: amir_sumbul@yahoo.co.in.
authors.forename: Amir
authors.initials: A
authors.lastname: Azam
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004748:Entamoeba histolytica / Q000187:drug effects*; D004749:Entamoebiasis / Q000188:drug therapy; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy; D019216:Metals, Heavy / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008958:Models, Molecular; D010963:Plasmodium falciparum / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C509669:4'-ferrocenyl-2,2':6',2' '-terpyridine; D000981:Antiprotozoal Agents; D056831:Coordination Complexes; D005296:Ferrous Compounds; D019216:Metals, Heavy; D011725:Pyridines
keywords: Amoebiasis; Ferrocenyl; Malaria; Metal complexes; Terpyridine