title: Concomitant progressive supranuclear palsy and chronic traumatic encephalopathy in a boxer.
abstract: We report the case of a 75-year-old ex-professional boxer who developed diplopia and eye movement abnormalities in his 60's followed by memory impairment, low mood and recurrent falls. Examination shortly before death revealed hypomimia, dysarthria, vertical supranuclear gaze palsy and impaired postural reflexes. Pathological examination demonstrated 4-repeat tau neuronal and glial lesions, including tufted astrocytes, consistent with a diagnosis of progressive supranuclear palsy. In addition, neurofibrillary tangles composed of mixed 3-repeat and 4-repeat tau and astrocytic tangles in a distribution highly suggestive of chronic traumatic encephalopathy were observed together with limbic TDP-43 pathology. Possible mechanisms for the co-occurrence of these two tau pathologies are discussed.
authors.forename: Helen
authors.initials: H
authors.lastname: Ling
authors.forename: Eleanna
authors.initials: E
authors.lastname: Kara
authors.forename: Tamas
authors.initials: T
authors.lastname: Revesz
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lees
authors.forename: Gordon T
authors.initials: GT
authors.lastname: Plant
authors.forename: Davide
authors.initials: D
authors.lastname: Martino
authors.forename: Henry
authors.initials: H
authors.lastname: Houlden
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.affiliation: Reta Lila Weston Institute of Neurological Studies, Queen Square Brain Bank for Neurological Disorders, UCL Institute of Neurology, University College London, London, UK. Janice.holton@ucl.ac.uk.
authors.forename: Janice L
authors.initials: JL
authors.lastname: Holton
mesh_terms: D000368:Aged; D020208:Brain Injury, Chronic / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D000077153:Progranulins; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D013494:Supranuclear Palsy, Progressive / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D016875:tau Proteins / Q000235:genetics
chemical_list: C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; C054369:MAPT protein, human; D000077153:Progranulins; D016875:tau Proteins; C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases