title: Clinical correlates of serum pigment epithelium-derived factor in type 2 diabetes patients.
abstract: OBJECTIVE
  To determine if serum pigment epithelium-derived factor (PEDF) levels in Type 2 diabetes are related to vascular risk factors and renal function.
  
  
  METHODS
  PEDF was quantified by ELISA in a cross-sectional study of 857 male Veterans Affairs Diabetes Trial (VADT) subjects, and associations with cardiovascular risk factors and renal function were determined. In a subset (n=246) in whom serum was obtained early in the VADT (2.0±0.3 years post-randomization), PEDF was related to longitudinal changes in renal function over 3.1 years.
  
  
  RESULTS
  Cross-sectional study: In multivariate regression models, PEDF was positively associated with serum triglycerides, waist-to-hip ratio, serum creatinine, use of ACE inhibitors or angiotensin receptor blockers, and use of lipid-lowering agents; it was negatively associated with HDL-C (all p<0.05). Longitudinal study: PEDF was not associated with changes in renal function over 3.1 years (p>0.09).
  
  
  CONCLUSIONS
  Serum PEDF in Type 2 diabetic men was cross-sectionally associated with dyslipidemia, body habitus, use of common drugs for blood pressure and dyslipidemia, and indices of renal function; however, PEDF was not associated with renal decline over 3.1years.
authors.affiliation: Centre for Experimental Medicine, Queen's University of Belfast, Belfast, N. Ireland; University of Sydney, NHMRC Clinical Trials Centre, Camperdown, Sydney, NSW, Australia.
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Jenkins
authors.affiliation: Centre for Experimental Medicine, Queen's University of Belfast, Belfast, N. Ireland.
authors.forename: Dongxu
authors.initials: D
authors.lastname: Fu
authors.affiliation: Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Madona
authors.initials: M
authors.lastname: Azar
authors.affiliation: College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Julie A
authors.initials: JA
authors.lastname: Stoner
authors.affiliation: Hines VA Cooperative Studies Program (CSP) Coordinating Center, Edward Hines Jr. VA Hospital, Hines, IL, USA.
authors.forename: Derrick G
authors.initials: DG
authors.lastname: Kaufman
authors.affiliation: Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Ross Eye Institute, Department of Ophthalmology, State University of New York at Buffalo, Buffalo, NY, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Division of Endocrinology, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Richard L
authors.initials: RL
authors.lastname: Klein
authors.affiliation: Division of Endocrinology, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Maria F
authors.initials: MF
authors.lastname: Lopes-Virella
authors.affiliation: Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: Jian-Xing
authors.initials: JX
authors.lastname: Ma
authors.affiliation: Centre for Experimental Medicine, Queen's University of Belfast, Belfast, N. Ireland; Section of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address: t.lyons@qub.ac.uk.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Lyons
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000453:epidemiology*; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology; D005136:Eye Proteins / Q000097:blood*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000503:physiopathology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D011237:Predictive Value of Tests; D012307:Risk Factors; D015843:Serpins / Q000097:blood*; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D015415:Biomarkers; D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor
keywords: Cardio-vascular risk factors; PEDF; Type 2 diabetes