title: Thin-beam ultrasound overestimation of blood flow: how wide is your beam?
abstract: It has been predicted that the development of thin-beam ultrasound could lead to an overestimation of mean blood velocity by up to 33% as beam width approaches 0% of vessel diameter. If both beam and vessel widths are known, in theory, this overestimation may be correctable. Therefore, we updated a method for determining the beam width of a Doppler ultrasound system, tested the utility of this technique and the information it provides to reliably correct for the error in velocity measurements, and explored how error-corrected velocity estimates impact the interpretation of in vivo data. Using a string phantom, we found the average beam width of four different probes varied across probes from 2.93 ± 0.05 to 4.41 ± 0.06 mm (mean ± SD) and with depth of insonation. Using this information, we tested the validity of a calculated correction factor to minimize the thin-beam error in mean velocity observed in a flow phantom with known diameter. Use of a correction factor reduced the overestimation from 39 ± 11 to 7 ± 9% (P < 0.05). Lastly, in vivo we explored how knowledge of beam width improves understanding of physiological flow conditions. In vivo, use of a correction factor reduced the overestimation of mean velocity from 23 ± 11 to -4 ± 9% (P < 0.05). Thus this large source of error is real, has been largely ignored by the early adaptors of Doppler ultrasound for vascular physiology studies in humans, and is correctable by the described techniques.
authors.affiliation: Department of Human Physiology, University of Oregon, Eugene, Oregon.
authors.forename: Tahisha M
authors.initials: TM
authors.lastname: Buck
authors.forename: Dylan C
authors.initials: DC
authors.lastname: Sieck
authors.forename: John R
authors.initials: JR
authors.lastname: Halliwill
mesh_terms: D055592:Biophysical Phenomena; D001783:Blood Flow Velocity / Q000502:physiology*; D018056:Hemorheology / Q000502:physiology; D006801:Humans; D057446:Hydrodynamics; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging; D012039:Regional Blood Flow / Q000502:physiology; D015203:Reproducibility of Results; D013815:Thermodilution / Q000379:methods / Q000706:statistics & numerical data; D018616:Ultrasonography, Doppler, Duplex / Q000379:methods* / Q000706:statistics & numerical data
keywords: Doppler; blood flow velocity; duplex; hemodynamics; regional blood flow; ultrasonography