title: Probabilistic risk assessment of the exposure to polybrominated diphenyl ethers via fish and seafood consumption in the Region of Valencia (Spain).
abstract: The study was carried out to estimate the dietary intake of polybrominated diphenyl ethers (PBDEs) in the Region of Valencia (Spain) in order to evaluate the resultant risk. The PBDE levels in fish and seafood (a total of 206 samples) were determined. Dietary intake was estimated using results of PBDE analyses in fish and seafood marketed in the Region of Valencia over the period 2007-2012 and data of the first Valencian Food Consumption Survey, conducted in 2010. Two scenarios were assumed for left-censored results: the lower-bound (LB) scenario, in which unquantified results (below the limit of quantification (LOQ)) were set to zero and the upper-bound (UB) scenario, in which unquantified results were set to the LOQ and two approaches (deterministic and probabilistic) were compared. The mean PBDE concentration in fish and seafood from Valencian markets was between 0.97 and 3.87 ngg(-1) w.w. and was similar to that reported recently by European Food Safety Authority (EFSA). Among the analysed congeners, BDE-47 showed the highest levels and salmon, mackerel and swordfish were the most contaminated species. The average estimated daily intake of the sum of PBDEs (upper bound scenario; probabilistic approach) for adults and children were 0.137 ngkg(-1) body weight (b.w.) day and 0.180 ngkgb.w.(-1)d(-1), respectively. In relation to risk analysis, calculated margins of exposure (MOEs) for the BDE-47, -99 and -153 congeners for children and do not indicate a health concern with respect to current dietary exposure in the Valencian Region and only 0.05% of the adult population and a 0.1% of children could be in risk derived by BDE-99 intake through fish.
authors.affiliation: Centre for Public Health Research (CSISP-FISABIO), 21, Avenida Catalunya, 46020 Valencia, Spain; Analytical Chemistry Department, Universit of Valencia, Edifici Jeroni Muñoz, Dr. Moliner 50, 46100 Burjassot, Spain. Electronic address: pardo_olg@gva.es.
authors.forename: Olga
authors.initials: O
authors.lastname: Pardo
authors.affiliation: Centre for Public Health Research (CSISP-FISABIO), 21, Avenida Catalunya, 46020 Valencia, Spain; Public Health Laboratory of Valencia, Spain.
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Beser
authors.affiliation: Centre for Public Health Research (CSISP-FISABIO), 21, Avenida Catalunya, 46020 Valencia, Spain; Analytical Chemistry Department, Universit of Valencia, Edifici Jeroni Muñoz, Dr. Moliner 50, 46100 Burjassot, Spain; Public Health Laboratory of Valencia, Spain.
authors.forename: Vicent
authors.initials: V
authors.lastname: Yusà
mesh_terms: D000818:Animals; D005399:Fishes; D059022:Food Safety; D055768:Halogenated Diphenyl Ethers / Q000032:analysis*; D006801:Humans; D011336:Probability; D018570:Risk Assessment; D017747:Seafood / Q000032:analysis*; D013030:Spain
chemical_list: C477694:2,2',4,4',5-brominated diphenyl ether; D055768:Halogenated Diphenyl Ethers; C511295:2,2',4,4'-tetrabromodiphenyl ether
keywords: Dietary exposure; Dietary intake; Monitoring; Polybrominated diphenyl ethers (PBDEs); Probabilistic risk assessment; Risk evaluation