title: Quantitative analysis of fragrance in selectable one dimensional or two dimensional gas chromatography-mass spectrometry with simultaneous detection of multiple detectors in single injection.
abstract: A selectable one-dimensional ((1)D) or two-dimensional ((2)D) gas chromatography-mass spectrometry (GC-MS) system coupled with flame ionization detector (FID) and olfactory detection port (ODP) was employed in this study to analyze perfume oil and fragrance in shower gel. A split/splitless (SSL) injector and a programmable temperature vaporization (PTV) injector are connected via a 2-way splitter of capillary flow technology (CFT) in this selectable (1)D/(2)D GC-MS/FID/ODP system to facilitate liquid sample injections and thermal desorption (TD) for stir bar sorptive extraction (SBSE) technique, respectively. The dual-linked injectors set-up enable the use of two different injector ports (one at a time) in single sequence run without having to relocate the (1)D capillary column from one inlet to another. Target analytes were separated in (1)D GC-MS/FID/ODP and followed by further separation of co-elution mixture from (1)D in (2)D GC-MS/FID/ODP in single injection without any instrumental reconfiguration. A (1)D/(2)D quantitative analysis method was developed and validated for its repeatability - tR; calculated linear retention indices (LRI); response ratio in both MS and FID signal, limit of detection (LOD), limit of quantitation (LOQ), as well as linearity over a concentration range. The method was successfully applied in quantitative analysis of perfume solution at different concentration level (RSD≤0.01%, n=5) and shower gel spiked with perfume at different dosages (RSD≤0.04%, n=5) with good recovery (96-103% for SSL injection; 94-107% for stir bar sorptive extraction-thermal desorption (SBSE-TD).
authors.affiliation: Firmenich Asia Pte Ltd, 10 Tuas West Road, 638377 Singapore.
authors.forename: Hui Peng
authors.initials: HP
authors.lastname: Tan
authors.affiliation: Firmenich Asia Pte Ltd, 10 Tuas West Road, 638377 Singapore.
authors.forename: Tow Shi
authors.initials: TS
authors.lastname: Wan
authors.affiliation: Firmenich Asia Pte Ltd, 10 Tuas West Road, 638377 Singapore.
authors.forename: Christina Liew Shu
authors.initials: CL
authors.lastname: Min
authors.affiliation: Firmenich Asia Pte Ltd, 10 Tuas West Road, 638377 Singapore.
authors.forename: Murray
authors.initials: M
authors.lastname: Osborne
authors.affiliation: Firmenich Asia Pte Ltd, 10 Tuas West Road, 638377 Singapore. Electronic address: khim.hui.ng@firmenich.com.
authors.forename: Khim Hui
authors.initials: KH
authors.lastname: Ng
mesh_terms: D005410:Flame Ionization; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D010476:Perfume / Q000737:chemistry*; D013696:Temperature; D014835:Volatilization
chemical_list: D010476:Perfume
keywords: Dual-linked injectors; Multidimensional gas chromatography–mass spectrometry; Perfume; Selectable (1)D/(2)D GC–MS/FID/ODP system; Stir-bar sorptive extraction; Thermal desorption