title: Comparative study of oral and vaginal misoprostol for induction of labour, maternal and foetal outcome.
abstract: BACKGROUND
  Misoprostol is a new promising agent for cervical ripening and induction of labour .The ideal dose, route and frequency of administration of misoprostol are still under investigation. Although, vaginal application of misoprostol has been validated as a reasonable mean of induction, there is a patient resistance to digital examination and there is a risk of ascending infection. For this reason, oral administration of misoprostol for cervical ripening and labour induction has been tried.
  
  
  OBJECTIVE
  To compare 50μg of oral misoprostol versus 25μg of intravaginal misoprostol for induction of labour at term and maternal, foetal outcomes.
  
  
  METHODS
  Two hundred women who were at term, with indication for induction of labour and Bishop scores of ≤5 were randomly assigned to receive misoprostol 50μg or 25μg intravaginal, every 4-6 hours, for a maximum of 5 doses. In either group, pregnant females with inadequate uterine contractions despite being given maximum 5 doses of misoprostol, were augmented using oxytocin. The primary outcome measure was time-interval from induction to vaginal delivery and vaginal delivery rate within 24 hours.
  
  
  RESULTS
  The median induction to vaginal delivery time in oral group (12.92h) and vaginal group (14.04 h) was not significant. Oral misoprostol resulted in more number of vaginal deliveries as compared to vaginal misoprostol (94% as compared to 86%), which was not significant. There was a significantly higher incidence of uterine tachysystole in the vaginal group, as compared to oral group. There were no significant differences between the groups with respect to oxytocin augmentation, caesarean section rate, analgesic requirement and neonatal outcome.
  
  
  CONCLUSIONS
  Oral misoprostol is as efficacious as vaginal misoprostol because of shorter induction delivery interval, lower caesarean section rates, and lower incidence of failed induction rates. Lower incidence of foetal distress and easy intake are observed if the drug is administered orally.
authors.affiliation: Senior Resident, Department of Obstetrics and Gynaecology, Princess Durru Shehvar Children's and General Hospital , Hyderabad, Andhra Pradesh, India .
authors.forename: Kambhampati
authors.initials: K
authors.lastname: Komala
authors.affiliation: Senior Resident, Department of Obstetrics and Gynaecology, Princess Durru Shehvar Children's and General Hospital , Hyderabad, Andhra Pradesh, India .
authors.forename: Meherlatha
authors.initials: M
authors.lastname: Reddy
authors.affiliation: Professor, Department of Obstetrics and Gynaecology, Princess Durru Shehvar Children's and General Hospital , Hyderabad, Andhra Pradesh, India .
authors.forename: Iqbal Jehan
authors.initials: IJ
authors.lastname: Quadri
authors.affiliation: Senior Resident, Department of Obstetrics and Gynaecology, Princess Durru Shehvar Children's and General Hospital , Hyderabad, Andhra Pradesh, India .
authors.forename: Suneetha
authors.initials: S
authors.lastname: B
authors.affiliation: Post Graduate, Department of Obstetrics and Gynaecology, Princess Durru Shehvar Children's and General Hospital , Hyderabad, Andhra Pradesh, India .
authors.forename: Ramya
authors.initials: R
authors.lastname: V
keywords: Bishop’s score; Labour induction; Oralmisoproptol; Vaginal misoprostol