title: Glycosylflavonoids from Cecropia pachystachya Trécul are quorum sensing inhibitors.
abstract: The Cecropia genus is widely distributed in Latin America including at least 60 species, and some of them are commonly used in traditional medicine for the treatment of several diseases. We used Cecropia pachystachya Trécul to search for quorum sensing (QS) inhibitors compounds and found that the aqueous extract of C. pachystachya leaves is a promising source of substances with this activity. Using as biosensor Chromobacterium violaceum ATCC 31532 and Escherichia coli pSB403, the compounds chlorogenic acid (2), isoorientin (3), orientin (4), isovitexin (6), vitexin (7), and rutin (9) were identified as QS inhibitors. None of these compounds inhibited the growth of neither the used biosensors nor the microorganisms Staphylococcus aureus ATCC 23591, Escherichia coli ATCC 25922 and Saccharomyces cerevisiae, used here as growth inhibition controls. Along with the rutin, here we presented for the first time the QS-inhibition potential of the C-glycosyl flavonoids. The prospective of this evidence lead to the use of these compounds as antipathogenic drugs or antifoulants.
authors.affiliation: Departamento de Química, Universidad Nacional de Colombia, Ciudad Universitaria, edificio 451, Carrera 30 N° 45-03, Bogotá, Colombia.
authors.forename: J
authors.initials: J
authors.lastname: Brango-Vanegas
authors.affiliation: Departamento de Química, Universidad Nacional de Colombia, Ciudad Universitaria, edificio 451, Carrera 30 N° 45-03, Bogotá, Colombia; Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, CEP 88040-970, Florianópolis, SC, Brazil.
authors.forename: G M
authors.initials: GM
authors.lastname: Costa
authors.affiliation: Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, CEP 88040-970, Florianópolis, SC, Brazil.
authors.forename: C F
authors.initials: CF
authors.lastname: Ortmann
authors.affiliation: Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, CEP 88040-970, Florianópolis, SC, Brazil.
authors.forename: E P
authors.initials: EP
authors.lastname: Schenkel
authors.affiliation: Programa de Pós-Graduação em Farmácia, Universidade Federal de Santa Catarina, Campus Universitário, Trindade, CEP 88040-970, Florianópolis, SC, Brazil.
authors.forename: F H
authors.initials: FH
authors.lastname: Reginatto
authors.affiliation: Departamento de Química, Universidad Nacional de Colombia, Ciudad Universitaria, edificio 451, Carrera 30 N° 45-03, Bogotá, Colombia.
authors.forename: F A
authors.initials: FA
authors.lastname: Ramos
authors.affiliation: Departamento de Biología, Universidad Nacional de Colombia, Ciudad Universitaria, edificio 221, Carrera 30 N° 45-03, Bogotá, Colombia.
authors.forename: C
authors.initials: C
authors.lastname: Arévalo-Ferro
authors.affiliation: Departamento de Química, Universidad Nacional de Colombia, Ciudad Universitaria, edificio 451, Carrera 30 N° 45-03, Bogotá, Colombia. Electronic address: lcastellanosh@unal.edu.co.
authors.forename: L
authors.initials: L
authors.lastname: Castellanos
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D015374:Biosensing Techniques; D035702:Cecropia Plant / Q000737:chemistry*; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D053038:Quorum Sensing / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D005419:Flavonoids; D005960:Glucosides
keywords: C-glycosyl flavonoids; Cecropia; Cecropia pachystachya Trécul; Flavonoids; Quorum sensing inhibitors; Rutin