title: Systemic Sclerosis Presenting with Simultaneous Retinal Vasculitis in One Eye and Optic Neuritis in the other along with Severe Immune Haemolytic Anaemia.
abstract: Systemic Sclerosis (SSc) is a connective tissue disorder which involves multiple systems in a chronic progressive manner. Micro-angiopathic haemolytic anaemia is a distinguished feature of "scleroderma renal crisis", which is manifested by severe hypertension, a rapidly progressing renal dysfunction and hyperreninaemia and is seen in patients with an early, diffuse form of the disease. A nervous system involvement is rare, though entrapment neuropathies have been reported. Who presented with a sequential loss of vision in both eyes; due to retinal vasculitis in right eye and optic nerve demyelination in the left eye. She also had severe Coombs' negative haemolytic anaemia in absence of any renal dysfunction or hypertension. Both the ophthalmologic and the haematologic manifestations are very rare and both responded well to oral prednisolone therapy.
authors.affiliation: Assistant Professor, Department of Medicine, Calcutta National Medical College , 24 Gorachand Road, Kolkata-700014, India .
authors.forename: Avijit
authors.initials: A
authors.lastname: Moulick
authors.affiliation: Assistant Professor, Department of Medicine, Calcutta National Medical College , 24 Gorachand Road, Kolkata-700014, India .
authors.forename: Biswanath Sharma
authors.initials: BS
authors.lastname: Sarkar
authors.affiliation: Senior Resident, Department of Medicine, Calcutta National Medical College , 24 Gorachand Road, Kolkata-700014, India .
authors.forename: Anirban
authors.initials: A
authors.lastname: Jana
authors.affiliation: Assistant Professor, Department of Medicine, Calcutta National Medical College , 24 Gorachand Road, Kolkata-700014, India .
authors.forename: Pradipta
authors.initials: P
authors.lastname: Guha
authors.affiliation: Associate Professor, Department of Pathology, Calcutta National Medical College , 24 Gorachand Road, Kolkata-700014, India .
authors.forename: Anjan
authors.initials: A
authors.lastname: Das
keywords: Autoimmune haemolytic anaemia; Optic neuritis; Retinal vasculitis; Systemic sclerosis