title: Systematic screening of common wastewater-marking pharmaceuticals in urban aquatic environments: implications for environmental risk control.
abstract: In this report, we refer to pharmaceuticals that are widespread in the urban aquatic environment and that mainly originate from wastewater treatment plants or non-point source sewage as "wastewater-marking pharmaceuticals" (WWMPs). To some extent, they reflect the condition or trend of water contamination and also contribute to aquatic environmental risk assessment. The method reported here for screening typical WWMPs was proposed based on academic concerns about them and their concentrations present in the urban aquatic environment, as well as their properties of accumulation, persistence, eco-toxicity and related environmental risks caused by them. The screening system consisted of an initial screening system and a further screening system. In the former, pharmaceuticals were categorised into different evaluation levels, and in the latter, each pharmaceutical was given a normalised final evaluation score, which was the sum of every score for its properties of accumulation, persistence, eco-toxicity and environmental risk in the aquatic environment. The system was applied to 126 pharmaceuticals frequently detected in the aquatic environment. In the initial screening procedure, five pharmaceuticals were classified into the "high" category, 16 pharmaceuticals into the "medium" category, 15 pharmaceuticals into the "low" category and 90 pharmaceuticals into the "very low" category. Subsequently, further screening were conducted on 36 pharmaceuticals considered as being of "high", "medium" and "low" categories in the former system. We identified 7 pharmaceuticals with final evaluation scores of 1-10, 10 pharmaceuticals with scores of 11-15, 15 pharmaceuticals with scores from 16 to 20 and 4 pharmaceuticals with scores above 21. The results showed that this screening system could contribute to the effective selection of target WWMPs, which would be important for spatial-temporal dynamics, transference and pollution control of pharmaceuticals in the urban aquatic environment. However, there remains a number of pharmaceutical parameters with measured data gaps, such as organic carbon adsorption coefficients and bioconcentration factors, which, if filled, would improve the accuracy of the screening system.
authors.affiliation: School of Environment and Architecture, University of Shanghai for Science and Technology, No. 516, Jungong Road, Shanghai, 200093, China, zhouhaidong@usst.edu.cn.
authors.forename: Haidong
authors.initials: H
authors.lastname: Zhou
authors.forename: Qingjun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xuelian
authors.initials: X
authors.lastname: Wang
authors.forename: Qianqian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lixin
authors.initials: L
authors.lastname: Ma
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhan
mesh_terms: D002947:Cities; D064420:Drug-Related Side Effects and Adverse Reactions; D004777:Environment; D004784:Environmental Monitoring / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000145:classification; D018570:Risk Assessment / Q000379:methods; D012722:Sewage / Q000737:chemistry; D062065:Wastewater / Q000032:analysis / Q000737:chemistry*; D014874:Water Pollutants, Chemical / Q000032:analysis*; D014876:Water Pollution / Q000032:analysis*
chemical_list: D004364:Pharmaceutical Preparations; D012722:Sewage; D062065:Wastewater; D014874:Water Pollutants, Chemical