title: A Drosophila circuit feels the (sleep) pressure.
abstract: How sleep is homeostatically regulated remains a mystery. In this issue of Neuron, Donlea et al. (2014) provide evidence in Drosophila that a set of sleep-inducing neurons require Crossveinless-c, a specific Rho-GTPase-activating protein (Rho-Gap), to alter their membrane excitability in response to sleep deprivation.
authors.affiliation: Department of Cell and Developmental Biology, University College London, Anatomy Building, Gower Street, London WC1E 6BT, UK.
authors.forename: Güliz Gürel
authors.initials: GG
authors.lastname: Ozcan
authors.affiliation: Department of Cell and Developmental Biology, University College London, Anatomy Building, Gower Street, London WC1E 6BT, UK. Electronic address: j.rihel@ucl.ac.uk.
authors.forename: Jason
authors.initials: J
authors.lastname: Rihel
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000235:genetics*; D006706:Homeostasis / Q000502:physiology*; D009154:Mutation / Q000235:genetics*; D009474:Neurons / Q000378:metabolism*; D012890:Sleep / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins; D020690:GTPase-Activating Proteins; C502709:cv-c protein, Drosophila