title: Near-infrared light-triggered drug-delivery vehicle for mitochondria-targeted chemo-photothermal therapy.
abstract: A novel drug-delivery vehicle for mitochondria-targeted chemo-photothermal therapy was demonstrated. A cytochrome c-specific binding aptamer was employed to make the mesoporous silica-encapsulated gold nanorods efficiently accumulate in the mitochondria of cancer cells. This nanocarrier can load various hydrophobic therapeutic agents acting on mitochondria to enhance the therapeutic efficiency and simultaneously depress the toxic side effects. In addition, near-IR treatment could induce cytochrome c release and initiation of the mitochondrial pathway of apoptosis. Importantly, this multifunctional platform could integrate targeting, light-triggered release, and chemo-photothermal therapy into one system. We hope that such a system could open the door to the fabrication of a multifunctional mitochondria-targeted drug-delivery vehicle for cancer therapy.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
authors.forename: Enguo
authors.initials: E
authors.lastname: Ju
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D045304:Cytochromes c / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004358:Drug Therapy; D006367:HeLa Cells; D006801:Humans; D007259:Infrared Rays; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D043942:Nanotubes / Q000737:chemistry; D010789:Phototherapy; D012402:Rotenone / Q000737:chemistry / Q000494:pharmacology
chemical_list: D004337:Drug Carriers; D012402:Rotenone; D045304:Cytochromes c