title: The superior longitudinal fasciculus in typically developing children and adolescents: diffusion tensor imaging and neuropsychological correlates.
abstract: The relationship between superior longitudinal fasciculus microstructural integrity and neuropsychological functions were examined in 49 healthy children (range: 5-17 years) using diffusion tensor imaging. Seven major cognitive domains (intelligence, fine-motor, attention, language, visual-spatial, memory, executive function) were assessed. Data analyses used correlational methods. After adjusting for age and gender, fractional anisotropy and axial diffusivity values in the superior longitudinal fasciculus were positively correlated with executive functions of set shifting, whereas left superior longitudinal fasciculus fractional anisotropy values correlated with attention and language. Apparent diffusion coefficient values in the left superior longitudinal fasciculus negatively correlated with inhibitory control. In the left arcuate fasciculus, fractional anisotropy correlated with IQ and attention, whereas radial diffusivity values negatively correlated with IQ, fine-motor skills, and expressive language. Findings from this study provide an examination of the relationship between superior longitudinal fasciculus integrity and children's neuropsychological abilities that can be useful in monitoring pediatric neurologic diseases.
authors.affiliation: Istanbul Cerrahi Hastanesi, Tesvikiye mahallesi, Istanbul, Turkey.
authors.forename: Sacide E
authors.initials: SE
authors.lastname: Urger
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC, USA michael.debellis@duke.edu.
authors.forename: Michael D
authors.initials: MD
authors.lastname: De Bellis
authors.affiliation: Department of Psychiatry and The Carolina Institute for Developmental Disabilities, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Hooper
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical School, Durham, NC, USA.
authors.forename: Donald P
authors.initials: DP
authors.lastname: Woolley
authors.affiliation: Department of Radiology, Duke University Medical School, Durham, NC, USA.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Chen
authors.affiliation: Department of Radiology, Duke University Medical School, Durham, NC, USA Departments of Radiology and Imaging Sciences, Oncology and Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: James
authors.initials: J
authors.lastname: Provenzale
mesh_terms: D000293:Adolescent; D016880:Anisotropy; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000254:growth & development*; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology; D003337:Corpus Callosum / Q000033:anatomy & histology* / Q000254:growth & development*; D056324:Diffusion Tensor Imaging; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000254:growth & development*; D009483:Neuropsychological Tests
keywords: cognitive function; diffusion tensor imaging; superior longitudinal fasciculus; typically developing youth