title: Ruthenium-catalyzed intramolecular [2+2+2] cycloaddition and tandem cross-metathesis of triynes and enediynes.
abstract: [2+2+2] Cycloadditions can be applied to specifically build up derivatives of benzene and cyclohexadiene and, therefore, have attracted much attention. Herein, we present an intramolecular [2+2+2] cycloaddition of triynes catalyzed by the first-generation Grubbs ruthenium complex (Ru gen-1), which can efficiently afford benzene derivatives in good yields under mild conditions. Moreover, we also report on a novel tandem cross-metathesis transformation of intramolecular enediynes also catalyzed by Ru gen-1, which has not been observed previously in related reports. On the basis of deuterium labeling experiments, a possible reaction mechanism is presented.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 354 Fenglin Lu, Shanghai 200032 (P. R. China) E-mail: Mshi@mail.sioc.ac.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 354 Fenglin Lu, Shanghai 200032 (P. R. China) E-mail: Mshi@mail.sioc.ac.cn.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wei
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 354 Fenglin Lu, Shanghai 200032 (P. R. China) E-mail: Mshi@mail.sioc.ac.cn.
authors.forename: Min
authors.initials: M
authors.lastname: Shi
keywords: cross-metathesis; cycloaddition; enediynes; first-generation Grubbs catalyst; triynes