title: Severe Aplastic Anemia Manifesting After Complete Remission of Acute Promyelocytic Leukemia: Is it a Fortuitous Association?
abstract: Acute leukemia, secondary myelodysplasia and paroxysmal nocturnal hemoglobinuria evolving from severe aplastic anemia (AA) following immunosuppressive therapy are well recognized. However, severe AA occurring after complete remission of acute promyelocytic leukemia (APL) has been documented only once in 2009. We report a case of 30-year-old male diagnosed with APL who achieved complete cytogenetic remission with all-trans retinoic acid based induction regimen and developed severe AA few months later during maintenance therapy.
authors.affiliation: Hi-Tech Laboratory, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum, Karnataka India ; Flat 3, Ruturaj Apartments, S P Office road, Kolhapur Circle, Belgaum, Karnataka 590016 India.
authors.forename: Rajeshwari Satish
authors.initials: RS
authors.lastname: Handigund
authors.affiliation: Hi-Tech Laboratory, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum, Karnataka India.
authors.forename: Prakash R
authors.initials: PR
authors.lastname: Malur
authors.affiliation: Department of Medicine, Jawaharlal Nehru Medical College, Belgaum, Karnataka India.
authors.forename: Annasaheb J
authors.initials: AJ
authors.lastname: Dhumale
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Belgaum, Karnataka India.
authors.forename: Akshay
authors.initials: A
authors.lastname: Bali
authors.affiliation: Department of Pathology, Jawaharlal Nehru Medical College, Belgaum, Karnataka India.
authors.forename: Maitrayee
authors.initials: M
authors.lastname: Roy
authors.affiliation: Hi-Tech Laboratory, KLES Dr. Prabhakar Kore Hospital and Medical Research Centre, Belgaum, Karnataka India.
authors.forename: Suvarna
authors.initials: S
authors.lastname: Inumella
keywords: ATRA; Acute promyelocytic leukemia; Severe aplastic anemia