title: The association between the Lys751Gln polymorphism in the XPD gene and the risk of bladder cancer.
abstract: The Lys751Gln polymorphism in the XPD gene have been suggested as a risk factor for bladder cancer, however the results were inconclusive. The aim of the current study is to assess the association by meta-analysis. A total of 15 case-control studies concerning the association between the XPD Lys751Gln polymorphism and bladder cancer risk were included in the meta-analysis. The results suggested that the Lys751Gln polymorphism was not associated with an increased risk of bladder cancer in the dominant model (OR = 1.03, 95 % CI 0.95-1.11, P = 0.53 for Lys/Gln+Gln/Gln vs. Lys/Lys) in overall analysis. In the subgroup analysis by ethnicity, no significant association was found in Caucasians or Asians. Other comparatives suggested a slight significant association between the polymorphism with the risk of bladder cancer in the recessive comparative (OR = 1.14, 95 % CI 1.02-1.29, P = 0.03). The current meta-analysis indicated that the Lys751Gln polymorphism in the XPD gene might be a risk factor for bladder cancer. In the future, more large-scale case-control studies are needed to validate our results.
authors.affiliation: West China Hospital/West China Medical School, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China.
authors.forename: Tianyuan
authors.initials: T
authors.lastname: Xiong
authors.forename: Jiqiao
authors.initials: J
authors.lastname: Yang
authors.forename: Haichuan
authors.initials: H
authors.lastname: Wang
authors.forename: Fanyi
authors.initials: F
authors.lastname: Wu
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.forename: Zi
authors.initials: Z
authors.lastname: Lv
authors.forename: Pei
authors.initials: P
authors.lastname: Xue
authors.forename: Wen
authors.initials: W
authors.lastname: Cao
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D019943:Amino Acid Substitution; D016022:Case-Control Studies; D003062:Codon; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D009687:Nuclear Proteins / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012306:Risk; D014157:Transcription Factors / Q000235:genetics*; D001749:Urinary Bladder Neoplasms / Q000235:genetics*; D000099250:DNA Excision Repair Protein ERCC-5
chemical_list: D003062:Codon; D004268:DNA-Binding Proteins; D004720:Endonucleases; D009687:Nuclear Proteins; D014157:Transcription Factors; D000099250:DNA Excision Repair Protein ERCC-5