title: Rapid resolution of protracted febrile myalgia syndrome with anakinra: Report of two cases.
abstract: Protracted febrile myalgia syndrome (PFMS) is a very rare but severe manifestation of familial Mediterranean fever (FMF) which is characterized by severe debilitating pain in large muscle groups that may last for several weeks. Colchicine is ineffective and treatment is largely supportive. Demonstration of crucial role of interleukin-1 (IL-1) in the pathogenesis of FMF has increased the use of IL-1 blockers in colchicine resistant or intolerant patients. Herein, we reported successful use of an IL-1 inhibitor, anakinra, in treatment of two patients with PFMS.
authors.affiliation: a Department of Internal Medicine , Division of Rheumatology, Gazi University Hospital , Ankara , Turkey.
authors.forename: Rıdvan
authors.initials: R
authors.lastname: Mercan
authors.affiliation: b Department of Radiology , Yildirim Beyazit Training and Research Hospital , Etlik, Ankara , Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Turan
authors.affiliation: a Department of Internal Medicine , Division of Rheumatology, Gazi University Hospital , Ankara , Turkey.
authors.forename: Berivan
authors.initials: B
authors.lastname: Bitik
authors.affiliation: a Department of Internal Medicine , Division of Rheumatology, Gazi University Hospital , Ankara , Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Tufan
authors.affiliation: a Department of Internal Medicine , Division of Rheumatology, Gazi University Hospital , Ankara , Turkey.
authors.forename: Seminur
authors.initials: S
authors.lastname: Haznedaroglu
authors.affiliation: a Department of Internal Medicine , Division of Rheumatology, Gazi University Hospital , Ankara , Turkey.
authors.forename: Berna
authors.initials: B
authors.lastname: Goker
mesh_terms: D000328:Adult; D010505:Familial Mediterranean Fever / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D063806:Myalgia / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein
keywords: Anakinra; Familial Mediterranean fever; Interleukin-1; Protracted febrile myalgia; Treatment