title: Impaired enzymatic antioxidant defense in erythrocytes of women with general and abdominal obesity.
abstract: OBJECTIVE
  The aim of this study was to investigate erythrocyte antioxidant enzyme activities in general and abdominal obese women.
  
  
  METHODS
  In this study, 160 women 20-45 years old were randomly selected. General information data were gathered from each sample using questionnaires and face-to-face interviews. Activities of erythrocyte antioxidant enzymes were also evaluated by measuring activities of copper zinc-superoxide dismutase (CuZn-SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in selected subjects.
  
  
  RESULTS
  Mean activity of CuZn-SOD was significantly lower in overweight and obese groups compared to normal weight group (721 ± 81 vs. 987 ± 84, p < 0.01 and 638 ± 74 vs. 987 ± 84, p < 0.001, respectively). Furthermore, both erythrocyte GSH-Px (97.6 ± 45.2 vs. 148.7 ± 54.2, p < 0.01) and CAT (184.2 ± 37.8 vs. 316.7 ± 65.8, p < 0.01) activities was significantly lower in obese women compared to normal weight women. In addition, women with abdominal obesity had lower erythrocyte CuZn-SOD (632 ± 76 vs. 871 ± 84, p < 0.001), GSH-Px (103.6 ± 52.8 vs. 154.7 ± 62.4, p < 0.01) and CAT (216.6 ± 76.4 vs. 298.3 ± 71.1, p < 0.05) activities compared to women with normal body fat distribution. Moreover, multiple linear regression analysis suggests higher prediction of waist circumference (i.e. higher R(2)) on antioxidant enzyme activities in relation to other adiposity indicators.
  
  
  CONCLUSIONS
  Our results provides further evidence suggesting that obesity and, especially, abdominal adiposity associated with decreased antioxidant enzyme activities which in turn, may contribute to oxidative stress related to obesity.
authors.affiliation: Department of Epidemiology and Biostatistics, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran. Electronic address:amirkhizi.f@gmail.com.
authors.forename: Farshad
authors.initials: F
authors.lastname: Amirkhizi
authors.affiliation: Department of Epidemiology and Biostatistics, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Fereydoun
authors.initials: F
authors.lastname: Siassi
authors.affiliation: Department of Epidemiology and Biostatistics, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Djalali
authors.affiliation: Department of Epidemiology and Biostatistics, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran.
authors.forename: Soudabeh Hamedi
authors.initials: SH
authors.lastname: Shahraki
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D056128:Obesity, Abdominal / Q000097:blood*; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D000975:Antioxidants; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase