title: "Orange alert": a fluorescent detector for bisphenol A in water environments.
abstract: Due to the prevalent use of polycarbonate plastics and epoxy resins in packaging materials and paints for ships, there has been a widespread global contamination of environmental water sources with bisphenol A (BPA). BPA, an endocrine disruptor, has been found to cause tremendous health problems. Therefore, there is an urgent need for detecting BPA in a convenient and sensitive manner to ensure water safety. Herein, we develop a fluorescent turn-on BPA probe, named Bisphenol Orange (BPO), which could conveniently detect BPA in a wide variety of real water samples including sea water, drain water and drinking water. BPO shows superior selectivity toward BPA and up to 70-fold increase in fluorescence emission at 580 nm when mixed with BPA in water. Mechanistic studies suggest a plausible water-dependent formation of hydrophobic BPA clusters which favorably trap and restrict the rotation of BPO and recover its inherent fluorescence.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543 Singapore, Singapore; Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, PR China.
authors.forename: Liyun
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543 Singapore, Singapore; Graduate School for Integrative Sciences and Engineering, National University of Singapore, Centre for Life Sciences, #05-01, 28 Medical Drive, 117456 Singapore, Singapore.
authors.forename: Jun Cheng
authors.initials: JC
authors.lastname: Er
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543 Singapore, Singapore.
authors.forename: Wang
authors.initials: W
authors.lastname: Xu
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543 Singapore, Singapore.
authors.forename: Xian
authors.initials: X
authors.lastname: Qin
authors.affiliation: Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), 138667 Singapore, Singapore.
authors.forename: Animesh
authors.initials: A
authors.lastname: Samanta
authors.affiliation: Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), 138667 Singapore, Singapore.
authors.forename: Santanu
authors.initials: S
authors.lastname: Jana
authors.affiliation: Centre for Biomedical and Life Sciences, Singapore Polytechnic, 139651 Singapore, Singapore.
authors.forename: Chi-Lik Ken
authors.initials: CL
authors.lastname: Lee
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 2, 117543 Singapore, Singapore; Graduate School for Integrative Sciences and Engineering, National University of Singapore, Centre for Life Sciences, #05-01, 28 Medical Drive, 117456 Singapore, Singapore; Singapore Bioimaging Consortium, Agency for Science, Technology and Research (A*STAR), 138667 Singapore, Singapore. Electronic address: chmcyt@nus.edu.sg.
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Chang
mesh_terms: D001559:Benzhydryl Compounds / Q000032:analysis*; D060766:Drinking Water / Q000737:chemistry; D052244:Endocrine Disruptors / Q000032:analysis; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D010636:Phenols / Q000032:analysis*; D012623:Seawater / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000032:analysis*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D060766:Drinking Water; D052244:Endocrine Disruptors; D005456:Fluorescent Dyes; D010636:Phenols; D014230:Triazoles; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Boron dipyrromethene; Fluorescent sensor; Water environments