title: Prognostic value of the International Society on Thrombosis and Haemostasis scoring system for overt disseminated intravascular coagulation in emergency department sepsis.
abstract: OBJECTIVE
  The International Society on Thrombosis and Haemostasis (ISTH) scoring system is a useful tool to diagnosis overt disseminated intravascular coagulation in clinical practice. The main purposes of this study were to investigate the prognostic value of the ISTH score in emergency department (ED) sepsis and compare the ISTH score with two established scoring systems, the Sequential Organ Failure Assessment (SOFA) score and Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and two biomarkers,procalcitonin (PCT) and C-reactive protein (CRP).
  
  
  METHODS
  Septic patients were consecutively enrolled from the ED of Beijing Chaoyang Hospital, China. The ISTH score, SOFA score and APACHE II score were calculated, and PCT and CRP levels were measured on enrollment. A 30-day follow-up was performed.
  
  
  RESULTS
  A total of 680 septic patients were enrolled in this study. The Cox regression analysis showed that the ISTH score had a greater effect on 30-day mortality prediction, and the receiver operating characteristic curve analysis showed that the accuracy of the ISTH score in prediction of 30-day mortality was better than the SOFA score, the APACHE II score, PCT and CRP. Combination of the ISTH score and CRP can enhance the predictive accuracy of 30-day mortality.
  
  
  CONCLUSIONS
  The ISTH score is a valuable scoring system in the prognosis evaluation in ED sepsis.
authors.affiliation: Emergency Department of Beijing Chaoyang Hospital, Capital Medical University, 8# Worker's Stadium South Road, Beijing, 100020, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Yin
authors.forename: B
authors.initials: B
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: C
authors.initials: C
authors.lastname: Li
mesh_terms: D000368:Aged; D002681:China; D015331:Cohort Studies; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis* / Q000473:pathology*; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D018805:Sepsis / Q000150:complications* / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D012720:Severity of Illness Index; D016019:Survival Analysis