title: Troponin T, NT-proBNP, and venous thromboembolism: the Longitudinal Investigation of Thromboembolism Etiology (LITE).
abstract: Increased levels of plasma troponins and natriuretic peptides are markers of cardiac dysfunction associated with increased risk of cardiovascular disease. Little information exists on cardiac dysfunction and occurrence of venous thromboembolism (VTE). In two prospective epidemiological cohorts, we tested the hypothesis that high-sensitivity troponin T (TnT) and N-terminal pro B-type natriuretic peptide (NT-proBNP) are associated positively with VTE occurrence. The Atherosclerosis Risk in Communities (ARIC) study and the Cardiovascular Health Study (CHS) measured plasma TnT and NT-proBNP in 13,719 men or women with no history of venous thrombosis, coronary heart disease, or heart failure and followed them for approximately 10 years for VTE occurrence (n = 348 VTEs). In both ARIC and CHS, TnT was associated positively with incidence of total VTE and provoked VTE, but not with unprovoked VTE: age, race, and sex-adjusted hazard ratios for total VTE in the pooled analysis were 1.00, 0.85, 1.36, 1.51, and 1.98 (p-trend <0.0001) across five categories of TnT. In contrast, the association of NT-proBNP with VTE was positive in ARIC (hazard ratios approximately 2.5-fold for the highest versus lowest NT-proBNP quintiles), but non-existent in CHS.
authors.affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, MN, USA.
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Folsom
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Lutsey
authors.forename: Vijay
authors.initials: V
authors.lastname: Nambi
authors.forename: Christopher R
authors.initials: CR
authors.lastname: deFilippi
authors.forename: Susan R
authors.initials: SR
authors.lastname: Heckbert
authors.forename: Mary
authors.initials: M
authors.lastname: Cushman
authors.forename: Christie M
authors.initials: CM
authors.lastname: Ballantyne
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D011446:Prospective Studies; D012307:Risk Factors; D020107:Troponin T / Q000378:metabolism*; D054556:Venous Thromboembolism / Q000209:etiology*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain
keywords: natriuretic peptides; pulmonary embolism; troponins; venous thrombosis