title: Identification and evaluation of drug-supplement interactions in Hungarian hospital patients.
abstract: BACKGROUND
  The increasing number of patients taking supplementary products together with prescribed medicines has become a new challenge for health care systems. These products may influence therapy outcomes by inducing unwanted effects. Particularly concerning is the potential for harmful interactions between prescribed medicines and supplementary products.
  
  
  OBJECTIVE
  The aims of the study were to evaluate supplement use, to identify and analyse potential interactions, and to assess the efficiency of computerised interaction screening.
  
  
  METHODS
  Participants of the study were inpatients and outpatients of a Hungarian university hospital.
  
  
  METHODS
  A cross-sectional point-of-care survey of 200 patients was carried out. Data was collected through personal interviews and a review of the medical records. Drug-drug, drug-supplement and supplement-supplement interactions were analysed with three interaction databases (Lexi-Interact Online, Medscape Drug Interaction Checker and Mediris).
  
  
  METHODS
  Prevalence of supplementary product use, number of medicines and supplementary products per patient, procurement sources of products, number of potentially severe interactions.
  
  
  RESULTS
  There was a marked difference between data obtained from patient interviews and the medical records. 85.5 % of the surveyed patients took supplementary products during the 2 weeks prior to the interview. The average number of prescribed medicines and supplementary products were 7.8 and 2.5, respectively. Women were more likely to take supplements than men. There was no significant difference in supplement use between patients under or over 60 years, between inpatients and outpatients and among patients in various wards. 39.4 % of supplementary products were purchased outside a regulated pharmacy environment. Potentially severe drug-supplement interactions were detected with 45.2 % of supplement users; however the majority of interactions were not included in one or the other of the three databases. In addition to that the risk ratings of the same interactions varied greatly between databases.
  
  
  CONCLUSIONS
  A significant number of patients are exposed to potential drug interactions with supplementary products; however interagreement among interaction databases is poor. Our data suggest that a full medication history should specifically address the intake of supplements.
authors.affiliation: Department of Pharmaceutics and Central Clinical Pharmacy, Medical School, University of Pécs, Honvéd u. 3., 7624, Pecs, Hungary, vegh.anna@pte.hu.
authors.forename: Anna
authors.initials: A
authors.lastname: Végh
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Lankó
authors.forename: András
authors.initials: A
authors.lastname: Fittler
authors.forename: Róbert György
authors.initials: RG
authors.lastname: Vida
authors.forename: Ildikó
authors.initials: I
authors.lastname: Miseta
authors.forename: Gábor
authors.initials: G
authors.lastname: Takács
authors.forename: Lajos
authors.initials: L
authors.lastname: Botz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D019587:Dietary Supplements / Q000009:adverse effects*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged