title: Cycloartane-type triterpene glycosides from Beesia calthaefolia and their anticomplement activity.
abstract: Two new 9,19-cycloartane triterpenes (1, 2), together with three known compounds (3-5), were isolated from the whole plant of Beesia calthaefolia. Their structures were determined by the application of spectroscopic analyses and chemical methods. Compound 1 showed moderate anticomplement activity similar to that of the positive control (rosmarinic acid), while compounds 3 and 4 showed weak activity. The results suggest that 6'-O-(4″-hydroxy-3″-methoxy-benzoyl)-β-D-glucosyl of 9,19-cycloartane-type triterpenoids could be a structure that is essential for anticomplement activity.
authors.affiliation: Department of Clinical Pharmacology, PLA General Hospital, Beijing, 100853, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Mu
authors.forename: Hong-Jie
authors.initials: HJ
authors.lastname: Li
authors.forename: Dai-Hong
authors.initials: DH
authors.lastname: Guo
authors.forename: Jin-Yuan
authors.initials: JY
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Liu
mesh_terms: D051056:Complement Inactivating Agents / Q000737:chemistry* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D029626:Ranunculaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D051056:Complement Inactivating Agents; D006027:Glycosides; D014315:Triterpenes; C085352:cycloartane