title: Biomedical properties of edible seaweed in cancer therapy and chemoprevention trials: a review.
abstract: This review article summarizes in vitro and in vivo experiments on seaweed anticancer activity and seaweed chemical components. Seaweed use in cancer therapy, chemopreventive randomized control trials (RCTs) and quasi-experiments are discussed. The literature reviewed in this article was obtained from various scientific sources and encompasses publications from 2000-2012. Seaweed therapeutic effects were deemed scientifically plausible and may be partially explained by the in vivo and in vitro pharmacological studies described. Although the mechanisms of action remain unclear, seaweed's anticancer properties may be attributable to its major biologically active metabolites. Much of the seaweed research outlined in this paper can serve as a foundation for explaining seaweed anticancer bioactivity. This review will open doors for developing strategies to treat malignancies using seaweed natural products.
authors.affiliation: Institute of Tropical Forestry and Forest Products (INTROP), Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. farideh.namvar@gmail.com
authors.forename: Farideh
authors.initials: F
authors.lastname: Namvar
authors.affiliation: Institute of Tropical Forestry and Forest Products (INTROP), Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
authors.forename: Paridah M d
authors.initials: PM
authors.lastname: Tahir
authors.affiliation: Institute of Tropical Forestry and Forest Products (INTROP), Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
authors.forename: Rosfarizan
authors.initials: R
authors.lastname: Mohamad
authors.affiliation: Shiraz Branch, Islamic Azad University, Shiraz, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Mahdavi
authors.affiliation: Reproductive Health Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
authors.forename: Parvin
authors.initials: P
authors.lastname: Abedi
authors.affiliation: Department ofMedicine, Applied Biology Research Center, Mashhad Branch, Islamic Azad University, Mashhad Iran.
authors.forename: Tahereh Fathi
authors.initials: TF
authors.lastname: Najafi
authors.affiliation: Department of Microbiology and Pathology, Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPMSerdang, Selangor, Malaysia.
authors.forename: Heshu Sulaiman
authors.initials: HS
authors.lastname: Rahmanand
authors.affiliation: Institute of Tropical Forestry and Forest Products (INTROP), Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Jawaid
mesh_terms: D000818:Animals; D018890:Chemoprevention; D006801:Humans; D009369:Neoplasms / Q000178:diet therapy* / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D012624:Seaweed