title: Antioxidant activity and glucose diffusion relationship of traditional medicinal antihyperglycemic plant extracts.
abstract: Plants with hypoglycemic properties are important in the treatment of diabetes. One of the mechanisms in reducing blood glucose is preventing the digestive absorption of glucose. The aim of this study was to evaluate the antioxidant properties of some traditional medicinal plants collected from different regions of Iran and their effects on glucose diffusion decrease. The amounts of phenolic compounds, total flavonoids, total polysaccharides, antioxidant activity and lipid peroxidation were determined respectively by folin ciocalteu, querceting, sulfuric acid, FRAP and thiobarbituric acid - reactive substanses (TBARS) in eleven confirmed traditional antihyperglycemic medicinal plants prepared at 50g/l concentrations using the boiling method. Phenolic compounds of Eucalyptus globules (100.8± 0.01 mg /g), total flavonoids content of Juglans regia (16.9± 0.01 mg /g) and total polysaccharide amount of Allium satirum (0.28± 0.05) were the highest. Significant relationship was observed between the polyphenols and flavonoids (p <0.05). The grape seed extract showed the highest antioxidant activity (133± 0.02 mg/g) together with decreased glucose diffusion as well as increased polyphenols (p <0.05), but the increase in antioxidant activity was not related to glucose diffusion. Antihyperglycemic plant extracts containing higher polyphenols showed more efficiently in vitro glucose diffusion decrease, but no significant relationship was observed between antioxidant activity increase and glucose diffusion.
authors.affiliation: Paramedical Faculty, Babol University of Medical Scienes, Babol, Iran.
authors.forename: Fariba
authors.initials: F
authors.lastname: Asgharpour
authors.affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Scienes, Babol, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Pouramir
authors.affiliation: Paramedical Faculty, Babol University of Medical Scienes, Babol, Iran.
authors.forename: Asieh
authors.initials: A
authors.lastname: Khalilpour
authors.affiliation: Bureau of Education, Rasht-Region 2, Rasht, Iran.
authors.forename: Sobgol
authors.initials: S
authors.lastname: Asgharpour Alamdar
authors.affiliation: Faculty of Veterinary Medicine University of Urumieh, Urumieh, Iran.
authors.forename: Mehrasa
authors.initials: M
authors.lastname: Rezaei
keywords: Antihyperglycemic plants; antioxidant activity; flavonoids; glucose diffusion; polyphenols