title: Promotion of artery occlusion in dogs by percutaneous rotational atherectomy.
abstract: BACKGROUND
  This study aims to offer experimental data and indirect evidences for the application of percutaneous rotational atherectomy to treat patent ductus arteriosus (PDA).
  
  
  METHODS
  Eleven dogs (6 male dogs and 5 female dogs; aged 14-20 months, with an average of 16.7±3.2 months; weight 20-25 kg, with an average of 22.7±2.5 kg) were enrolled in this study. The diameters of the left and right arteries ranged from 3.2 to 4.8 mm (average 3.9±0.6 mm) on percutaneous angiography. Percutaneous rotational atherectomy with proper rotablator (the size was 1-1.5 mm larger than the artery diameter) was performed in the arterial intima. After 4 weeks from percutaneous rotational atherectomy, arteriography was conducted to observe the changes in artery diameter. Then all dogs were sacrificed and the pathologic examination was conducted on the left and right axillary arteries.
  
  
  RESULTS
  There were obvious changes with different degrees in 22 arteries, including 8 arteries with complete occlusion and 12 arteries with stenosis (≥2/3, 1/2, and 1/3 stenosis in 4, 4, and 4 arteries, respectively). The occlusion rate was 36.4% and the total effective rate was 90.9%. It was considered failure in other 2 arteries with <1/3 of stenosis.
  
  
  CONCLUSIONS
  Percutaneous rotational atherectomy of arterial intima can promote the occlusion of arteries. This has provided a new choice for the treatment of PDA.
authors.affiliation: Department of Congenital Heart Disease, Cardiovascular Research Institute of PLA, General Hospital of Shenyang Military Command, Shenyang, China. Electronic address: chuanjuhou@163.com.
authors.forename: Chuan-Ju
authors.initials: CJ
authors.lastname: Hou
authors.affiliation: Department of Congenital Heart Disease, Cardiovascular Research Institute of PLA, General Hospital of Shenyang Military Command, Shenyang, China.
authors.forename: Duan-Zhen
authors.initials: DZ
authors.lastname: Zhang
authors.affiliation: Department of Congenital Heart Disease, Cardiovascular Research Institute of PLA, General Hospital of Shenyang Military Command, Shenyang, China.
authors.forename: Qi-Guang
authors.initials: QG
authors.lastname: Wang
authors.affiliation: Department of Congenital Heart Disease, Cardiovascular Research Institute of PLA, General Hospital of Shenyang Military Command, Shenyang, China.
authors.forename: Chun-Sheng
authors.initials: CS
authors.lastname: Cui
authors.affiliation: Department of Congenital Heart Disease, Cardiovascular Research Institute of PLA, General Hospital of Shenyang Military Command, Shenyang, China.
authors.forename: Li
authors.initials: L
authors.lastname: Kuang
authors.affiliation: Department of Congenital Heart Disease, Cardiovascular Research Institute of PLA, General Hospital of Shenyang Military Command, Shenyang, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Congenital Heart Disease, Cardiovascular Research Institute of PLA, General Hospital of Shenyang Military Command, Shenyang, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
mesh_terms: D015901:Angiography, Digital Subtraction; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D017073:Atherectomy / Q000295:instrumentation*; D001366:Axillary Artery; D004195:Disease Models, Animal; D004285:Dogs; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D008297:Male; D016896:Treatment Outcome