title: Impact of geographic and transportation-related barriers on HIV outcomes in sub-Saharan Africa: a systematic review.
abstract: Difficulty obtaining reliable transportation to clinic is frequently cited as a barrier to HIV care in sub-Saharan Africa (SSA). Numerous studies have sought to characterize the impact of geographic and transportation-related barriers on HIV outcomes in SSA, but to date there has been no systematic attempt to summarize these findings. In this systematic review, we summarized this body of literature. We searched for studies conducted in SSA examining the following outcomes in the HIV care continuum: (1) voluntary counseling and testing, (2) pre-antiretroviral therapy (ART) linkage to care, (3) loss to follow-up and mortality, and (4) ART adherence and/or viral suppression. We identified 34 studies containing 52 unique estimates of association between a geographic or transportation-related barrier and an HIV outcome. There was an inverse effect in 23 estimates (44 %), a null association in 26 (50 %), and a paradoxical beneficial impact in 3 (6 %). We conclude that geographic and transportation-related barriers are associated with poor outcomes across the continuum of HIV care.
authors.affiliation: Departments of Internal Medicine and Pediatrics, University of Pennsylvania, Philadelphia, PA, USA, alexlankowski@gmail.com.
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Lankowski
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Siedner
authors.forename: David R
authors.initials: DR
authors.lastname: Bangsberg
authors.forename: Alexander C
authors.initials: AC
authors.lastname: Tsai
mesh_terms: D017954:Africa South of the Sahara; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018890:Chemoprevention; D003266:Continuity of Patient Care; D003376:Counseling / Q000458:organization & administration* / Q000706:statistics & numerical data; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006297:Health Services Accessibility / Q000458:organization & administration*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D014186:Transportation / Q000592:standards*; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents