title: CFTR structure and cystic fibrosis.
abstract: CFTR (cystic fibrosis transmembrane conductance regulator) is a member of the ATP-binding cassette family of membrane proteins. Although almost all members of this family are transporters, CFTR functions as a channel with specificity for anions, in particular chloride and bicarbonate. In this review we look at what is known about CFTR structure and function within the context of the ATP-binding cassette family. We also review current strategies aimed at obtaining the high resolution structure of the protein.
authors.affiliation: University of Manchester, Faculty of Life Sciences, Michael Smith Building, Manchester M13 9PT, UK.
authors.forename: Natasha
authors.initials: N
authors.lastname: Cant
authors.affiliation: University of Manchester, Faculty of Life Sciences, Michael Smith Building, Manchester M13 9PT, UK.
authors.forename: Naomi
authors.initials: N
authors.lastname: Pollock
authors.affiliation: University of Manchester, Faculty of Life Sciences, Michael Smith Building, Manchester M13 9PT, UK. Electronic address: robert.ford@manchester.ac.uk.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Ford
mesh_terms: D003550:Cystic Fibrosis / Q000235:genetics / Q000378:metabolism*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D017433:Protein Structure, Secondary
chemical_list: D019005:Cystic Fibrosis Transmembrane Conductance Regulator
keywords: CFTR; Cystic fibrosis; Ion channel; Membrane protein; Protein structure