title: Nanotoxicity: a key obstacle to clinical translation of siRNA-based nanomedicine.
abstract: siRNAs have immense therapeutic potential for the treatment of various gene-related diseases ranging from cancer, viral infections and neuropathy to autoimmune diseases. However, their bench-to-bedside translation in recent years has faced several challenges, with inefficient siRNA delivery being one of the most frequently encountered issues. In order to improve the siRNA delivery especially for systemic treatment, nanocarriers made of polymers, lipids or inorganic materials have become almost essential. The 'negative' aspects of these carriers such as their nanotoxicity and immunogenicity thus can no longer be overlooked. In this article, we will extensively review the nanotoxicity of siRNA carriers. The strategies for mitigating the risks of nanotoxicity and the methodology for evaluating these strategies will also be discussed. By addressing this often overlooked but important issue, it will help clear the way for siRNAs to fulfill their promise as a versatile class of therapeutic agents.
authors.affiliation: School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA.
authors.forename: Hui Yi
authors.initials: HY
authors.lastname: Xue
authors.forename: Shimeng
authors.initials: S
authors.lastname: Liu
authors.forename: Ho Lun
authors.initials: HL
authors.lastname: Wong
mesh_terms: D004337:Drug Carriers; D050997:Nanomedicine; D034741:RNA, Small Interfering / Q000235:genetics*; D018675:Toxicity Tests
chemical_list: D004337:Drug Carriers; D034741:RNA, Small Interfering