title: Pyrazoline: a promising scaffold for the inhibition of monoamine oxidase.
abstract: In the five membered nitrogen containing heterocyclic family, pyrazoline could be recognized as a promising scaffold for the inhibition of Monoamine oxidase. Substitution at 1, 3 and 5-position of the pyrazoline nucleus displayed a significant activity towards MAO in the past 15 years. Our study identified the detailed structure activity relationship, the structural requirement for enzyme interaction and the effect of chirality on the pyrazoline nucleus towards MAO-A and MAO-B. We propose that the selectivity of pyrazoline nucleus towards MAO isoenzyme depends up on the bulkiness of the ring in the 1 and 3 position of the scaffold. The current review revealed that the derivatives of pyrazolines have proven to be versatile pharmacophores for the inhibition of MAO on the basis of existing literatures between (1998-2013).
authors.forename: Bijo
authors.initials: B
authors.lastname: Mathew
authors.forename: Jerad
authors.initials: J
authors.lastname: Suresh
authors.forename: Sockalingam
authors.initials: S
authors.lastname: Anbazhagan
authors.affiliation: Department of Pharmaceutical Chemistry Grace College of Pharmacy, Palakkad 678004, Kerala, India. bijovilaventgu@gmail.com.
authors.forename: Githa Elizabeth
authors.initials: GE
authors.lastname: Mathew
mesh_terms: D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008968:Molecular Conformation; D008995:Monoamine Oxidase / Q000737:chemistry / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D011720:Pyrazoles; D008995:Monoamine Oxidase