title: Two-step synthesis of difluoromethyl-substituted 2,3-dihydrobenzoheteroles.
abstract: 3-Difluoromethylated 2,3-dihydrobenzoheteroles, 2,3-dihydrobenzofurans, 2,3-dihydrobenzothiophenes, and indolines were readily synthesized from ortho-heterosubstituted bromobenzenes, 2-bromophenols, 2-bromobenzenethiols, and 2-bromoanilines, respectively, in two steps: (1) γ-selective allylic substitution of 3-bromo-3,3-difluoropropene with heteronucleophiles and (2) intramolecular radical cyclization of the resulting 3,3-difluoroallylic compounds.
authors.affiliation: Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba , Tsukuba, Ibaraki 305-8571, Japan.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fujita
authors.forename: Shohei
authors.initials: S
authors.lastname: Sanada
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Chiba
authors.forename: Kazuki
authors.initials: K
authors.lastname: Sugiyama
authors.forename: Junji
authors.initials: J
authors.lastname: Ichikawa