title: Prins cascade cyclization for the synthesis of 1,9-dioxa-4-azaspiro[5.5]undecane derivatives.
abstract: A novel Prins cascade process for the synthesis of 1,9-dioxa-4- azaspiro[5.5]undecane derivatives by the coupling of aldehydes with N-(4-hydroxy-2-methylenebutyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide has been developed. This is the first report of the synthesis of spiromorpholinotetrahydropyran derivatives through a Prins bicyclization.
authors.affiliation: Natural Product Chemistry, ‡Laboratory of X-ray Crystallography, and §Centre for Nuclear Magnetic Resonance, Indian Institute of Chemical Technology , Hyderabad-500 007, India.
authors.forename: B V Subba
authors.initials: BV
authors.lastname: Reddy
authors.forename: Durgaprasad
authors.initials: D
authors.lastname: Medaboina
authors.forename: B
authors.initials: B
authors.lastname: Sridhar
authors.forename: Kiran Kumar
authors.initials: KK
authors.lastname: Singarapu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D053961:Azabicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D013449:Sulfonamides / Q000737:chemistry*; D000096926:Benzenesulfonamides
chemical_list: D000447:Aldehydes; D053961:Azabicyclo Compounds; D013449:Sulfonamides; C000592525:1,9-dioxa-4-azaspiro(5.5)undecane; C000592590:N-(4-hydroxy-2-methylenebutyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide; D000096926:Benzenesulfonamides