title: Pharmacokinetics of ofloxacin and levofloxacin for prevention and treatment of multidrug-resistant tuberculosis in children.
abstract: Limited data on fluoroquinolone pharmacokinetics and cardiac effects in children exist. Among 22 children receiving drug-resistant tuberculosis prophylaxis or treatment, serum concentrations following oral doses of levofloxacin (15 mg/kg of body weight) and ofloxacin (20 mg/kg) were lower than those expected from existing pediatric data, possibly due to differences in the formulations (crushed tablets). Drug exposures were lower than those in adults following standard doses and below the proposed pharmacodynamic targets, likely due to more rapid elimination in children. No QT prolongation was observed.
authors.affiliation: Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa.
authors.forename: S
authors.initials: S
authors.lastname: Thee
authors.forename: A J
authors.initials: AJ
authors.lastname: Garcia-Prats
authors.forename: H M
authors.initials: HM
authors.lastname: McIlleron
authors.forename: L
authors.initials: L
authors.lastname: Wiesner
authors.forename: S
authors.initials: S
authors.lastname: Castel
authors.forename: J
authors.initials: J
authors.lastname: Norman
authors.forename: H R
authors.initials: HR
authors.lastname: Draper
authors.forename: P L
authors.initials: PL
authors.lastname: van der Merwe
authors.forename: A C
authors.initials: AC
authors.lastname: Hesseling
authors.forename: H S
authors.initials: HS
authors.lastname: Schaaf
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D064704:Levofloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D008297:Male; D015242:Ofloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D011446:Prospective Studies; D018088:Tuberculosis, Multidrug-Resistant / Q000097:blood / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D064704:Levofloxacin; D015242:Ofloxacin