title: Association between neutrophil-lymphocyte ratio and mitral annular calcification.
abstract: Mitral annular calcification (MAC) is closely related to cardiovascular disorders including coronary artery disease, atherosclerosis, heart failure, and stroke. The clinical risk factors for cardiovascular diseases, including age, obesity, hypertension, hyperlipidemia, and diabetes mellitus, are the same for MAC and atherosclerosis. The aim of this study was to assess the neutrophil-lymphocyte ratio (NLR), an inflammatory marker, in patients with MAC. The study group consisted of 117 patients with MAC. Age and sex-matched control group was composed of 38 patients who were admitted to echocardiography laboratory due to suspicion of organic heart disease and eventually found to be free of MAC. We measured hematological indices in patients and control individuals. NLR ratio was significantly higher in patients with MAC than in control individuals (3.3 ± 1.8 vs. 1.6 ± 0.4, respectively; P < 0.001), and NLR ratio was positively correlated with MAC (P < 0.001, r = 0.58). Red cell distribution width was also significantly higher in patients with MAC than in control individuals (16.2 ± 3.3 vs. 13.4 ± 0.9%, respectively; P < 0.001). We have shown that NLR was significantly elevated in patients with MAC and it was correlated with MAC.
authors.affiliation: Department of Cardiology, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
authors.forename: Fatih
authors.initials: F
authors.lastname: Aksoy
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozaydin
authors.forename: Dogan
authors.initials: D
authors.lastname: Erdogan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dogan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology*; D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000473:pathology*; D016022:Case-Control Studies; D002452:Cell Count; D004909:Erythrocyte Indices; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000473:pathology*; D009504:Neutrophils / Q000473:pathology*; D014463:Ultrasonography