title: H. pylori infection, inflammation and gastric cancer.
abstract: BACKGROUND
  A strong association between chronic infection, inflammation, and cancer has been suggested.
  
  
  CONCLUSIONS
  Helicobacter pylori, a microaerophilic gram negative bacterium, infects about half the world's population. It has been defined as a definitive carcinogen in the pathogenesis of gastric cancer. H. pylori evades the host immune responses and persists in the stomach leading to gastritis gastric atrophy and sometimes gastric cancer.
  
  
  CONCLUSIONS
  Chronic H. pylori infection causes gastric cancer via two mechanisms: the presence of virulence factors and the induction of chronic inflammation which ultimately leads to neoplastic transformation.
authors.affiliation: Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Jammu and Kashmir, 190011, India, qurteebaqadri@gmail.com.
authors.forename: Qurteeba
authors.initials: Q
authors.lastname: Qadri
authors.forename: Roohi
authors.initials: R
authors.lastname: Rasool
authors.forename: G M
authors.initials: GM
authors.lastname: Gulzar
authors.forename: Sameer
authors.initials: S
authors.lastname: Naqash
authors.forename: Zafar A
authors.initials: ZA
authors.lastname: Shah
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D016481:Helicobacter Infections / Q000150:complications* / Q000821:virology; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007249:Inflammation / Q000209:etiology*; D013274:Stomach Neoplasms / Q000209:etiology*