title: MyD88 and IL-1: loosening T(reg) cells' firm grip.
abstract: Immune suppression by T(reg) cells must be overcome to mount robust and effective anti-pathogen immune responses. A new paper in Immunity from Medzhitov and colleagues shows that IL-1-dependent activation of MyD88 promotes the development of Th1 cells by rendering them impervious to T(reg) cell-mediated inhibition.
authors.affiliation: Benaroya Research Institute, Seattle WA, USA; Department of Immunology, University of Washington School of Medicine, Seattle WA, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Campbell
mesh_terms: D000818:Animals; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology*; D053594:Myeloid Differentiation Factor 88 / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D007375:Interleukin-1; D053594:Myeloid Differentiation Factor 88