title: Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer.
abstract: Helicobacter pylori (H. pylori) infection is strongly associated with gastric cancer. However, only a minority of infected individuals ever develop gastric cancer. This risk stratification may be in part due to differences among strains. The relationship between neutrophil-activating protein (NapA) and gastric cancer is unclear. The purpose of this study is to evaluate the significance of NapA as a biomarker in gastric cancer. We used enzyme linked immunosorbent assay (ELISA) to determine the status of H. pylori infection. Indirect ELISA method was used for detection of NapA antibody titer in the serum of H. pylori infected individuals. Unconditional logistic regressions were adopted to analyze the variables and determine the association of NapA and gastric cancer. The results of study indicated serum H. pylori NapA antibody level were associated with a reduced risk for development of gastric cancer. It may be used in conjugation with other indicators for gastric cancer detection.
authors.affiliation: 1] Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China [2].
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.affiliation: 1] Department of neurology, The forth affiliated hospital, Harbin Medical University, Harbin 150001, Heilongjiang Province, P. R. China [2].
authors.forename: Huimin
authors.initials: H
authors.lastname: Liu
authors.affiliation: Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China.
authors.forename: Tingting
authors.initials: T
authors.lastname: Zhang
authors.affiliation: Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China.
authors.forename: Xiyun
authors.initials: X
authors.lastname: Ren
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, Pharmacy Building, 7 Greenhouse Road, Kingston, RI 02881, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Nadolny
authors.affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, The University of Rhode Island, Pharmacy Building, 7 Greenhouse Road, Kingston, RI 02881, USA.
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Dong
authors.affiliation: Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China.
authors.forename: Lina
authors.initials: L
authors.lastname: Huang
authors.affiliation: Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China.
authors.forename: Kexin
authors.initials: K
authors.lastname: Yuan
authors.affiliation: Department of Epidemiology, College of Public Health, Harbin Medical University, Harbin, Heilongjiang Province, P. R. China.
authors.forename: Wenjing
authors.initials: W
authors.lastname: Tian
authors.affiliation: Department of Colorectal Cancer Surgery, The third affiliated hospital, Harbin Medical University, Harbin 150081, Heilongjiang Province, P. R. China.
authors.forename: Yunhe
authors.initials: Y
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies / Q000097:blood*; D001426:Bacterial Proteins / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000175:diagnosis / Q000473:pathology; D016480:Helicobacter pylori / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D000906:Antibodies; D001426:Bacterial Proteins; D014408:Biomarkers, Tumor; C092412:neutrophil-activating protein A, Helicobacter pylori