title: Molecular imaging of late somatostatin receptor-positive metastases of renal cell carcinoma in the pancreas by 68Ga DOTATOC PET/CT: a rare differential diagnosis to multiple primary pancreatic neuroendocrine tumors.
abstract: Ga somatostatin receptor PET/CT, currently the most sensitive imaging modality for well-differentiated neuroendocrine tumors, is based on the molecular imaging of somatostatin receptors (SSTRs) that are expressed in different tumor entities such as neuroendocrine neoplasms, lymphomas, meningiomas, or renal cell cancer (RCC). Most neuroendocrine neoplasms show a high expression of SSTR subtypes 2A and 5, whereas the overexpression of SSTR2A in RCC is mainly seen in peritumoral vessels. Here we report a case with strongly SSTR-positive pancreatic lesions detected by Ga DOTATOC PET/CT, which histologically turned out to be ultralate metastases of a RCC.
authors.affiliation: From the *Department of General and Visceral Surgery, Zentralklinik Bad Berka, ENETS Center of Excellence; †Laboratory of Pathology and Cytology; and ‡Department of Molecular Radiotherapy/Center for Molecular Imaging (PET/CT), Zentralklinik Bad Berka, ENETS Center of Excellence, Bad Berka, Germany.
authors.forename: Luisa
authors.initials: L
authors.lastname: Peter
authors.forename: Jörg
authors.initials: J
authors.lastname: Sänger
authors.forename: Merten
authors.initials: M
authors.lastname: Hommann
authors.forename: Richard Paul
authors.initials: RP
authors.lastname: Baum
authors.forename: Daniel
authors.initials: D
authors.lastname: Kaemmerer
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D064847:Multimodal Imaging; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging* / Q000473:pathology; D018358:Neuroendocrine Tumors / Q000000981:diagnostic imaging* / Q000473:pathology; D015282:Octreotide / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: C499142:Ga(III)-DOTATOC; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D015282:Octreotide