title: Multi-element distribution profile in Sprague-Dawley rats: effects of intratracheal instillation of Cr(VI) and Zn intervention.
abstract: Our previous epidemiological study revealed that co-exposure of [Cr(VI)] with small amount of heavy metals could induce peripheral blood element imbalance, but little was known about the contribution of Cr(VI) itself and the multi-element distribution profile in other target tissues. We explored element homeostasis in the blood, RBC, serum and lung after Cr(VI) exposure and Zn intervention. 60 Sprague-Dawley male rats received intratracheal instillation of Cr(VI) (0, 0.063, 0.630mgCr/kg) weekly and/or intragastric administration of zinc sulfate (0, 10mgZn/kg) daily for one month. Element contents and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) concentrations were determined. Dose-response relationship was observed among rats exposed to Cr(VI). Ca, Mg, Mn in the blood, Fe, Mg, Se in the serum, and Mg and Zn in lung tissue decreased significantly, while Ca, Co, Cr, Mg, Mn, Se in RBC, and Ca, Co, Mo in the lung increased after Cr(VI) exposure. The alteration trends manifested differently, with RBC the most sensitive. Cr induced increase of urinary 8-OHdG, which decreased after Zn intervention. Zn intervention could help to restore element homeostasis after Cr(VI) exposure, especially for Ca, Fe, Mg and Se.
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Yanshuang
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Tianjing
authors.initials: T
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Ji
authors.initials: J
authors.lastname: Pu
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Jian
authors.initials: J
authors.lastname: Guo
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Zhangjian
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China.
authors.forename: Yun
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, PR China. Electronic address: jiaguangjia@bjmu.edu.cn.
authors.forename: Guang
authors.initials: G
authors.lastname: Jia
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002273:Carcinogens / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D002840:Chromates / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D002857:Chromium / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D017680:Potassium Compounds / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014018:Tissue Distribution; D014131:Trace Elements / Q000097:blood / Q000378:metabolism*; D019287:Zinc Sulfate / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D002273:Carcinogens; D002840:Chromates; D017680:Potassium Compounds; D014131:Trace Elements; D002857:Chromium; C074702:chromium hexavalent ion; C027373:potassium chromate(VI); D019287:Zinc Sulfate; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine
keywords: Element homeostasis; Hexavalent chromium [Cr(VI)]; Oxidative stress; SD rat; Zinc intervention