title: An intriguing pH-triggered FRET-based biosensor emission of a pyrazoline-doxorubicin couple and its application in living cells.
abstract: A unique pH-driven Förster resonance energy transfer (FRET) based biosensor emission by a pyrazoline-doxorubicin pair has been deciphered with a bioimaging application in a live HepG2 cell whereas conformational switching of both molecules at elevated pH reveals a fascinating twist (FRET-OFF) via strong fluorescent exciplex formation.
authors.affiliation: Department of Chemistry, Jadavpur University, Kolkata - 700032, India. sbjuchem@yahoo.com scbhattacharyya@chemistry.jdvu.ac.in.
authors.forename: Dipak Kumar
authors.initials: DK
authors.lastname: Rana
authors.forename: Sayaree
authors.initials: S
authors.lastname: Dhar
authors.forename: Subhash Chandra
authors.initials: SC
authors.lastname: Bhattacharya
mesh_terms: D015374:Biosensing Techniques; D004317:Doxorubicin / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018613:Microscopy, Confocal; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D011720:Pyrazoles; D004317:Doxorubicin