title: The course of gastric cancer following surgery is associated with genetic variations of the interleukin-1 receptor antagonist and interleukin-1β.
abstract: BACKGROUND
  Inflammation, especially the cytokine response of the IL-1 family, has been shown to influence susceptibility to gastric cancer. In addition, several other pro-inflammatory cytokines have been demonstrated to influence metastasis and resistance to chemotherapy. Therefore, genetic variations within these genes may not only affect susceptibility but also influence the outcome of gastric cancer patients. A limited number of studies showed indeed an association of IL-1β and IL-1RN variations with survival of gastric cancer patients. However, results are inconsistent, possibly because of different patient cohorts and different therapies.
  
  
  METHODS
  In this retrospective cohort study we genotyped 154 patients with gastric cancer for IL-1β and IL-1RN variations. Patients had undergone pathologically proven R0 resection and had received no additional adjuvant treatment.
  
  
  RESULTS
  We show here a protective association with disease-free survival for both heterozygous genotypes, IL-1β SNP C-511T (rs16944) and IL-1RN VNTR. The combination of both heterozygous genotypes is the strongest predictor independent of UICC stage.
  
  
  CONCLUSIONS
  Genetic variations in the IL-1β and IL-1RN genes influence disease progression in gastric cancer. Screening for these genetic variations might help to stratify therapies for gastric cancer patients in the future.
authors.affiliation: Institute for Microbiology and Hygiene, Charité University Medicine Berlin, Hindenburgdamm 27, 12203, Berlin, Germany.
authors.forename: Anke H
authors.initials: AH
authors.lastname: van der Ploeg
authors.forename: Oliver
authors.initials: O
authors.lastname: Kumpf
authors.forename: Evelyn
authors.initials: E
authors.lastname: Seelow
authors.forename: Luis C Berrocal
authors.initials: LC
authors.lastname: Almanza
authors.forename: Peter M
authors.initials: PM
authors.lastname: Schlag
authors.forename: Ralf R
authors.initials: RR
authors.lastname: Schumann
authors.forename: Lutz
authors.initials: L
authors.lastname: Hamann
mesh_terms: D000368:Aged; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D006579:Heterozygote; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta