title: Penibruguieramine A, a novel pyrrolizidine alkaloid from the endophytic fungus Penicillium sp. GD6 associated with Chinese mangrove Bruguiera gymnorrhiza.
abstract: A novel pyrrolizidine alkaloid, penibruguieramine A (1), characterized by an unprecedented 1-alkenyl-2-methyl-8-hydroxymethylpyrrolizidin-3-one skeleton, was isolated from the endophytic fungus Penicillium sp. GD6, associated with the Chinese mangrove Bruguiera gymnorrhiza. The absolute configuration of penibruguieramine A (1) was established by TDDFT ECD calculations of the vacuum and solution conformers, exploiting the transitions of the lactam chromophore. A plausible pathway for its biosynthesis has been proposed.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203, People's Republic of China.
authors.forename: Zhen-Fang
authors.initials: ZF
authors.lastname: Zhou
authors.forename: Tibor
authors.initials: T
authors.lastname: Kurtán
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Yang
authors.forename: Attila
authors.initials: A
authors.lastname: Mándi
authors.forename: Mei-Yu
authors.initials: MY
authors.lastname: Geng
authors.forename: Bo-Ping
authors.initials: BP
authors.lastname: Ye
authors.forename: Orazio
authors.initials: O
authors.lastname: Taglialatela-Scafati
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D011763:Pyrrolizidine Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D043982:Rhizophoraceae / Q000382:microbiology*
chemical_list: D011763:Pyrrolizidine Alkaloids; C000588723:penibruguieramine A