title: Monitoring peptide processing for MHC class I molecules in the endoplasmic reticulum.
abstract: Classical MHC class I molecules open a window into the cell by presenting intracellular peptides (pMHC I) on the surface. The peptides are used for immune surveillance by circulating CD8+ T and NK cells to detect and eliminate infected or tumor cells. Not surprisingly, viruses and tumor cells have evolved immune evasion mechanisms to keep the window shades down and the cytotoxic cells oblivious to their presence. Here, we review counter mechanisms that nevertheless allow the immune system to detect and eliminate cells unable to properly process antigenic peptides in the endoplasmic reticulum.
authors.affiliation: Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. Electronic address: nshastri@berkeley.edu.
authors.forename: Nilabh
authors.initials: N
authors.lastname: Shastri
authors.affiliation: Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
authors.forename: Niranjana
authors.initials: N
authors.lastname: Nagarajan
authors.affiliation: Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
authors.forename: Kristin C
authors.initials: KC
authors.lastname: Lind
authors.affiliation: Department of Pathology, School of Medicine, Sapporo Medical University, Sapporo, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kanaseki
mesh_terms: D000626:Aminopeptidases / Q000172:deficiency / Q000378:metabolism; D000818:Animals; D017951:Antigen Presentation / Q000235:genetics / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D004721:Endoplasmic Reticulum / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007694:Killer Cells, Natural / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D051379:Mice; D015778:Minor Histocompatibility Antigens; D015166:Monitoring, Immunologic / Q000379:methods*; D010446:Peptide Fragments / Q000172:deficiency / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D013234:Stem Cells / Q000201:enzymology / Q000276:immunology / Q000473:pathology; D013379:Substrate Specificity / Q000235:genetics / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D015778:Minor Histocompatibility Antigens; D010446:Peptide Fragments; D000626:Aminopeptidases; C464841:ERAP1 protein, human