title: Extrapontine myelinolysis in an 18-month-old boy with diabetic ketoacidosis: case report and literature review.
abstract: Extrapontine myelinolysis is characterized by symmetric demyelination following rapid shifts in serum osmolality in the supratentorial compartment. Extrapontine myelinolysis in children is rare compared to adults. The most common underlying pathophysiology is rapid correction of hyponatremia. Only 2 cases were published after diabetic ketoacidosis without electrolyte imbalance in the English literature. This study presents an unusual and possibly the youngest case of extrapontine myelinolysis that occurred in the setting of diabetic ketoacidosis and complicated cerebral edema without electrolyte imbalance, along with a review of the literature.
authors.affiliation: Department of Child Neurology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Pinar
authors.initials: P
authors.lastname: Gencpinar
authors.affiliation: Department of Pediatric Intensive Care, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Tekguc
authors.affiliation: Department of Radiology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: A Utku
authors.initials: AU
authors.lastname: Senol
authors.affiliation: Department of Child Neurology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.
authors.forename: Ozgur
authors.initials: O
authors.lastname: Duman
authors.affiliation: Department of Pediatric Intensive Care, Faculty of Medicine, Akdeniz University, Antalya, Turkey oguzdursun@akdeniz.edu.tr.
authors.forename: Oguz
authors.initials: O
authors.lastname: Dursun
mesh_terms: D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000097:blood / Q000150:complications / Q000473:pathology; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D017590:Myelinolysis, Central Pontine / Q000097:blood / Q000150:complications* / Q000473:pathology
keywords: children; diabetic ketoacidosis; extrapontine myelinolysis