title: Evolution of implantable and insertable drug delivery systems.
abstract: The paper describes the development of implantable and insertable drug delivery systems (IDDS) from their early stage in the 1960s until the current stage in the 2010s. It gives a detailed summary of non-degradable and biodegradable systems and their applications in different areas such as vascular disease treatment, birth control, cancer treatment, and eye disease treatment. It also describes the development of various implantable pump systems and some other atypical IDDS, the challenges and the future of IDDS.
authors.affiliation: POLTECO Inc., Hayward, CA 94545, USA.
authors.forename: Lothar W
authors.initials: LW
authors.lastname: Kleiner
authors.affiliation: DURECT Corporation, Cupertino, CA 95014, USA.
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Wright
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, PR China. Electronic address: yunbing.wang@yahoo.com.
authors.forename: Yunbing
authors.initials: Y
authors.lastname: Wang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D004343:Drug Implants; D004867:Equipment Design; D006801:Humans; D015918:Infusion Pumps, Implantable
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D004343:Drug Implants
keywords: Bioresorbable vascular scaffold; Drug implant; Drug-eluting stent; Implantable drug delivery system; Implantable pump; Insertable drug delivery system