title: [Cardiology. Platelet function testing for clinicians].
abstract: Platelet P2YI2 receptor inhibition with clopidogrel, prasugrel or ticagrelor plays a key role to prevent recurrent ischaemic events after percutaneous coronary intervention in acute coronary syndromes or elective settings. The degree of platelet inhibition depends on the antiplatelet medication used and is influenced by clinical and genetic factors. A concept of therapeutic window exists. On one side, efficient anti-aggregation is required in order to reduce cardio-vascular events. On the other side, an excessive platelet inhibition represents a risk of bleeding complications. This article describes the current knowledge about some platelet function tests and genetic tests and summarises their role in the clinical practice.
authors.affiliation: Institut de Cardiologie, lnserm UMRS937, Hôpital de la Pitié-Salpêtrière Université Paris, France. cyril.pellaton@chuv.ch
authors.forename: Cyril
authors.initials: C
authors.lastname: Pellaton
authors.affiliation: Institut de Cardiologie, lnserm UMRS937, Hôpital de la Pitié-Salpêtrière Université Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Eeckhout
authors.affiliation: Institut de Cardiologie, lnserm UMRS937, Hôpital de la Pitié-Salpêtrière Université Paris, France.
authors.forename: Johanne
authors.initials: J
authors.lastname: Silvain
authors.affiliation: Institut de Cardiologie, lnserm UMRS937, Hôpital de la Pitié-Salpêtrière Université Paris, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Montalescot
authors.affiliation: Institut de Cardiologie, lnserm UMRS937, Hôpital de la Pitié-Salpêtrière Université Paris, France.
authors.forename: Jean-Phillipe
authors.initials: JP
authors.lastname: Collet
mesh_terms: D002309:Cardiology / Q000379:methods / Q000639:trends*; D000077144:Clopidogrel; D005820:Genetic Testing; D006801:Humans; D062645:Percutaneous Coronary Intervention / Q000379:methods / Q000534:rehabilitation; D015539:Platelet Activation / Q000187:drug effects / Q000235:genetics; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010979:Platelet Function Tests / Q000706:statistics & numerical data; D011364:Professional Practice / Q000639:trends; D013988:Ticlopidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine
vernacular_title: Cardiologie. Tests de réactivité plaquettaire: mise à jour pour le praticien.