title: HSP70 polymorphisms in first psychotic episode drug-naïve schizophrenic patients.
abstract: OBJECTIVE
  The aim of this study is to investigate differences in HSPA8 polymorphisms between first-episode psychotic (FEP) schizophrenic patients and healthy participants after adjustment for temperamental personality traits.
  
  
  METHODS
  This study included fifty drug-naive schizophrenic patients with an FEP and fifty healthy participants who served as controls. Genotyping of HSPA8 polymorphisms was performed in patients and healthy subjects as well. Personality characteristics were assessed using the standardized Greek version of the Alternative Five-Factor Zuckerman-Kuhlman Personality Questionnaire (ZKPQ).
  
  
  RESULTS
  Our results showed that FEP patients presented a polymorphism differentiation related to the HSPA8 gene (rs1136141), and a higher frequency of T carriers compared to healthy controls was observed. The HSP8A polymorphism and the levels of Neuroticism as measured by the Alternative Five-Factor ZKPQ were the variables most closely and independently associated with FEP in multiple logistic regression analysis, and the odds of being assessed with a FEP was 2.8 times greater in T carriers compared to non-carriers.
  
  
  CONCLUSIONS
  Present findings indicate a role of HSP8A in FEP and underline the importance of including personality traits in the study of the factors associated with the development of schizophrenia.
authors.affiliation: Department of Pharmacology, Medical School, University of Ioannina, 45110 Ioannina, Greece; Department of Microbiology, Medical School, University of Ioannina, 45110 Ioannina, Greece.
authors.forename: Petros
authors.initials: P
authors.lastname: Bozidis
authors.affiliation: Department of Psychiatry, Medical School, University of Ioannina, 45110 Ioannina, Greece.
authors.forename: Thomas
authors.initials: T
authors.lastname: Hyphantis
authors.affiliation: Department of Psychiatry, Medical School, University of Ioannina, 45110 Ioannina, Greece.
authors.forename: Christos
authors.initials: C
authors.lastname: Mantas
authors.affiliation: Department of Pharmacology, Medical School, University of Ioannina, 45110 Ioannina, Greece.
authors.forename: Marianthi
authors.initials: M
authors.lastname: Sotiropoulou
authors.affiliation: Institute of Psychiatry, University of Bologna, 40123 Bologna, Italy.
authors.forename: Niki
authors.initials: N
authors.lastname: Antypa
authors.affiliation: 3rd Department of Psychiatry, Aristotle University of Thessaloniki, Greece.
authors.forename: Elias
authors.initials: E
authors.lastname: Andreoulakis
authors.affiliation: Institute of Psychiatry, University of Bologna, 40123 Bologna, Italy.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.affiliation: Department of Psychiatry, Medical School, University of Ioannina, 45110 Ioannina, Greece.
authors.forename: Venetsanos
authors.initials: V
authors.lastname: Mavreas
authors.affiliation: Department of Pharmacology, Medical School, University of Ioannina, 45110 Ioannina, Greece. Electronic address: kantoniu@cc.uoi.gr.
authors.forename: Katerina
authors.initials: K
authors.lastname: Antoniou
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004247:DNA / Q000235:genetics; D005260:Female; D005838:Genotype; D050883:HSC70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010551:Personality / Q000235:genetics; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011618:Psychotic Disorders / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D050883:HSC70 Heat-Shock Proteins; C494371:HSPA8 protein, human; D004247:DNA
keywords: First episode psychosis; Heat shock proteins 70; Personality