title: Photophysicochemical behavior and antimicrobial activity of dihydroxosilicon tris(diaquaplatinum)octacarboxyphthalocyanine.
abstract: Platination of dihydroxosilicon octacarboxyphthalocyanine (OH)2SiOCPc was successfully carried out to give dihydroxosilicon tris(diaquaplatinum)octacarboxyphthalocyanine (OH)2SiOCPc(Pt)3 conjugate. Slight blue shifting of the absorption spectrum of (OH)2SiOCPc(Pt)3 was observed on conjugation with platinum. Comparative photophysicochemical behavior and antimicrobial photo-activities of (OH)2SiOCPc(Pt)3 conjugate with (OH)2SiOCPc or Pt nanoparticles revealed that the heavy atom, Pt on the periphery of the phthalocyanine significantly enhanced its singlet oxygen generation with a quantum yield of 0.56 obtained for the (OH)2SiOCPc(Pt)3 conjugate. The (OH)2SiOCPc(Pt)3 conjugate showed highest antimicrobial activity towards Candida albicans and Escherichia coli compared to (OH)2SiOCPc and Pt nanoparticles alone under illumination.
authors.affiliation: Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa.
authors.forename: Muthumuni
authors.initials: M
authors.lastname: Managa
authors.affiliation: Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa; Department of Chemistry, Federal University of Agriculture, P.M.B. 2240, Abeokuta, Nigeria. Electronic address: maidowu408@yahoo.com.
authors.forename: Mopelola Abidemi
authors.initials: MA
authors.lastname: Idowu
authors.affiliation: Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa.
authors.forename: Edith
authors.initials: E
authors.lastname: Antunes
authors.affiliation: Department of Chemistry, Rhodes University, P.O. Box 94, Grahamstown 6140, South Africa.
authors.forename: Tebello
authors.initials: T
authors.lastname: Nyokong
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000528:radiation effects; D004926:Escherichia coli / Q000187:drug effects; D008027:Light; D050296:Microbial Viability / Q000187:drug effects / Q000528:radiation effects; D053758:Nanoparticles / Q000648:ultrastructure; D009944:Organoplatinum Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010984:Platinum / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013052:Spectrometry, X-Ray Emission; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D009944:Organoplatinum Compounds; D026082:Singlet Oxygen; D010984:Platinum
keywords: Diaquaplatinum; Octacarboxyphthalocyanine; Photodynamic antimicrobial chemotherapy (PACT); Platination; Singlet oxygen quantum yield