title: Immunohistochemical expression of p16 in Carcinoma Ex-pleomorphic Adenoma (undifferentiated and Adenocarcinoma Types).
abstract: OBJECTIVE
  This study was aimed at characterizing alterations in the immunohistochemical expression of p16 in carcinoma ex-pleomorphic adenomas.
  
  
  METHODS
  A selected series of 27 cases of carcinoma ex-pleomorphic adenomas were examined.
  
  
  RESULTS
  The results showed that p16 expression in non tumour duct cells was strongly positive nuclear staining in 23 (85%) cases out of 27 cases, that 3 (11.1%) had moderate staining, and that 1 (3.7%) had weak staining. p16 expression in carcinoma ex-pleomorphic adenomas was indicated as a negative nuclear staining in 22 (81.4%) cases out of 27cases, and 5 (18.5%) cases expressed moderate staining.
  
  
  CONCLUSIONS
  This study suggests that alteration of p16 expression is detected in carcinoma ex-pleomorphic adenomas. p16 has a role in development of carcinoma ex-pleomorphic adenomas.
authors.affiliation: Faculty, Head of Department of Oral Maxillofacial Sciences, Alfarabi College of Dentistry and Nursing , Kingdom of Saudi Arabia, Riyadh .
authors.forename: Bassel
authors.initials: B
authors.lastname: Tarakji
authors.affiliation: Faculty, Department of Restorative Dental Sciences, Alfarabi College of Dentistry and Nursing , Kingdom of Saudi Arabia, Riyadh .
authors.forename: Mohammed Alsakran
authors.initials: MA
authors.lastname: Altamimi
authors.affiliation: Faculty, Department of Restorative Dental Sciences, Alfarabi College of Dentistry and Nursing , Kingdom of Saudi Arabia, Riyadh .
authors.forename: Kusai
authors.initials: K
authors.lastname: Baroudi
authors.affiliation: Faculty, Department of Restorative Dental Sciences, Alfarabi College of Dentistry and Nursing , Kingdom of Saudi Arabia, Riyadh .
authors.forename: Mohammad Z
authors.initials: MZ
authors.lastname: Nassain
authors.affiliation: Faculty, College of Applied Medical Sciences, Prince Salman University , Al-Kharj, Saudi Arabia .
authors.forename: Faris Q
authors.initials: FQ
authors.lastname: Alenzi
keywords: CDKN2 gene; p16 expression