title: Secondary Hemophagocytic Syndrome Associated with Richter's Transformation in Chronic Lymphocytic Leukemia.
abstract: Hemophagocytic syndrome (HPS) is an extremely rare condition arising from the overactivation of one's own immune system. It results in excessive inflammation and tissue destruction. Prompt initiation of treatment is warranted in either scenario in order to decrease mortality. Most cases are triggered by infectious agents, malignancy, or drugs. We describe the first case of a CLL patient presenting with HPS due to acquisition of EBV-related large cell lymphoma in the setting of profound immunodeficiency.
authors.affiliation: Trinity College, Dublin, Ireland.
authors.forename: Nura
authors.initials: N
authors.lastname: El-Haj
authors.affiliation: Department of Hematology, Mayo Clinic Rochester, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: Wilson I
authors.initials: WI
authors.lastname: Gonsalves
authors.affiliation: Department of Hematology, Mayo Clinic Rochester, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: Vinay
authors.initials: V
authors.lastname: Gupta
authors.affiliation: Department of Hematology, Mayo Clinic Rochester, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: Jacob P
authors.initials: JP
authors.lastname: Smeltzer
authors.affiliation: Department of Hematology, Mayo Clinic Rochester, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: Sameer A
authors.initials: SA
authors.lastname: Parikh
authors.affiliation: Department of Hematology, Mayo Clinic Rochester, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: Preet P
authors.initials: PP
authors.lastname: Singh
authors.affiliation: Department of Hematology, Mayo Clinic Rochester, 200 1st Street SW, Rochester, MN 55905, USA.
authors.forename: Naseema
authors.initials: N
authors.lastname: Gangat