title: Hippocampal synaptic plasticity, spatial memory and anxiety.
abstract: Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, UK.
authors.forename: David M
authors.initials: DM
authors.lastname: Bannerman
authors.affiliation: Max Planck Institute for Medical Research, D-69120 Heidelberg, Germany.
authors.forename: Rolf
authors.initials: R
authors.lastname: Sprengel
authors.affiliation: Department of Psychology, Durham University, Durham, DH1 3LE, UK.
authors.forename: David J
authors.initials: DJ
authors.lastname: Sanderson
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, UK.
authors.forename: Stephen B
authors.initials: SB
authors.lastname: McHugh
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, UK.
authors.forename: J Nicholas P
authors.initials: JN
authors.lastname: Rawlins
authors.affiliation: Department of Clinical Neurobiology, Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
authors.forename: Hannah
authors.initials: H
authors.lastname: Monyer
authors.affiliation: Max Planck Institute for Medical Research, D-69120 Heidelberg, Germany.
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeburg
mesh_terms: D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001522:Behavior, Animal / Q000502:physiology; D006624:Hippocampus / Q000502:physiology* / Q000503:physiopathology; D008568:Memory / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009473:Neuronal Plasticity / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism; D013028:Space Perception / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate