title: Biochemical and nutritional markers and antioxidant activity in metabolic syndrome.
abstract: OBJECTIVE
  1) Nutritional assessment of the diet followed by patients with metabolic syndrome, and 2) biochemical analysis of the oxidation-reduction level in patients with metabolic syndrome.
  
  
  METHODS
  A cross-sectional study was conducted in patients with metabolic syndrome in Murcia. Fifty-three patients, 33 with and 20 without (control group) metabolic syndrome, were selected. The intervention consisted of completion of a recall survey and a test to nutritionally assess dietary intake. Anthropometric and laboratory variables, including those related to antioxidant activity, were also tested.
  
  
  RESULTS
  Antioxidant activity was within normal limits in both groups (1.7 ± 0.2 mmol/L in the control group and 1.8 ± 0.1 mmol/L in the metabolic syndrome group) (NS). Superoxide dismutase levels were not significantly different between the groups. Mean glutathione reductase levels (U/L) were higher in the control group as compared to patients with metabolic syndrome (P<.05). As regards oxidative stress biomarkers, mean isoprostane levels were higher in the control group (4.9 ± 6.2 ng/mL) than in metabolic syndrome patients (3.5 ± 3.9 ng/mL) (P<.05). Oxidized LDL values tended to be higher in metabolic syndrome patients (96 ± 23.2U/L) as compared to the control group (86.2 ± 17.3 U/L), but differences were not significant.
  
  
  CONCLUSIONS
  There is a trend to a poorer nutritional and biochemical profile in patients with metabolic syndrome, who also tend to have a greater degree of oxidative stress.
authors.affiliation: Cátedra de Riesgo Cardiovascular, Universidad Católica de Murcia, Guadalupe, Murcia, España.
authors.forename: Juana
authors.initials: J
authors.lastname: Bernabé García
authors.affiliation: Cátedra de Riesgo Cardiovascular, Universidad Católica de Murcia, Guadalupe, Murcia, España.
authors.forename: Pilar
authors.initials: P
authors.lastname: Zafrilla Rentero
authors.affiliation: Cátedra de Riesgo Cardiovascular, Universidad Católica de Murcia, Guadalupe, Murcia, España.
authors.forename: Juana
authors.initials: J
authors.lastname: Mulero Cánovas
authors.affiliation: Cátedra de Riesgo Cardiovascular, Universidad Católica de Murcia, Guadalupe, Murcia, España.
authors.forename: Purificación
authors.initials: P
authors.lastname: Gómez Jara
authors.affiliation: Cátedra de Riesgo Cardiovascular, Universidad Católica de Murcia, Guadalupe, Murcia, España.
authors.forename: Mariano
authors.initials: M
authors.lastname: Leal Hernández
authors.affiliation: Cátedra de Riesgo Cardiovascular, Universidad Católica de Murcia, Guadalupe, Murcia, España. Electronic address: jabellan@pdi.ucam.edu.
authors.forename: José
authors.initials: J
authors.lastname: Abellán Alemán
mesh_terms: D000368:Aged; D000886:Anthropometry; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D003430:Cross-Sectional Studies; D004032:Diet; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D009749:Nutrition Surveys; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012494:Sampling Studies; D013030:Spain; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D001786:Blood Glucose; D001798:Blood Proteins; D008055:Lipids; D006710:Homocysteine; D014527:Uric Acid; D014508:Urea; D002097:C-Reactive Protein
keywords: Antioxidant; Antioxidante; Isoprostanes; Isoprostanos; Metabolic syndrome; Nutrición; Nutrition; Síndrome metabólico