title: Toxic effects of zearalenone on oxidative stress, inflammatory cytokines, biochemical and pathological changes induced by this toxin in the kidney of pregnant rats.
abstract: An experiment was conducted to determine the toxic effects of zearalenone (ZEN) on oxidative stress, inflammatory cytokines, biochemical and pathological changes in the kidney of pregnant rats, and to explore the possible mechanism in ZEN induced kidney damage. The rats were fed a normal diet treated with 0.3, 48.5, 97.6 or 146 mg/kg ZEN in feed on gestation days (GDs) 0 through 7, and then all the rats were fed with a normal diet on GDs 8 through 20. The results showed that ZEN induced kidney dysfunction, oxidative damage, pathological changes and increased mRNA and protein expression of TLR4 and inflammatory cytokines in kidney in dose-dependent manner. The results indicated that ZEN caused kidney damage of pregnant rats and TLR4-mediated inflammatory reactions signal pathway was one of the mechanisms of ZEN mediated toxicity in kidney.
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, PR China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, PR China.
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, PR China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Qu
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, PR China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, PR China.
authors.forename: Shutong
authors.initials: S
authors.lastname: Yin
authors.affiliation: Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, PR China. Electronic address: asshan@neau.edu.cn.
authors.forename: Anshan
authors.initials: A
authors.lastname: Shan
mesh_terms: D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism; D017207:Rats, Sprague-Dawley; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000378:metabolism*; D051996:Transcription Factor RelA / Q000235:genetics / Q000378:metabolism; D015025:Zearalenone / Q000633:toxicity*
chemical_list: D016207:Cytokines; D012333:RNA, Messenger; C495347:Tlr4 protein, rat; D051197:Toll-Like Receptor 4; D051996:Transcription Factor RelA; D015025:Zearalenone
keywords: Biochemical and pathological changes; Inflammatory cytokines; Kidney; Oxidative stress; Pregnant rats; Zearalenone