title: Survivin beyond physiology: orchestration of multistep carcinogenesis and therapeutic potentials.
abstract: Survivin, a member of the inhibitor of apoptosis protein family, has been associated with protection from cell apoptosis and regulation of mitosis. Survivin exhibits low to undetectable expression in most finally differentiated adult tissues but is abundantly over-expressed in almost all cancers. The aberrant high expression of survivin in cancers is associated with advanced disease, increased rate of tumor recurrence, abbreviated overall survival and resistance to chemo- and radio- therapy. Survivin touches nearly every aspect of cancer and is involved in the initiation, maintenance and development of tumor. Therefore, its significance in cancer dictates the pursuit for anti-survivin cancer therapies.
authors.affiliation: First Department of Medicine, "Laiko" General Hospital, University of Athens, Medical School, Athens, Greece. Electronic address: kathanasoula@gmail.com.
authors.forename: Kalliopi Ch
authors.initials: KCh
authors.lastname: Athanasoula
authors.affiliation: First Department of Medicine, "Laiko" General Hospital, University of Athens, Medical School, Athens, Greece.
authors.forename: Helen
authors.initials: H
authors.lastname: Gogas
authors.affiliation: First Department of Medicine, "Laiko" General Hospital, University of Athens, Medical School, Athens, Greece.
authors.forename: Katerina
authors.initials: K
authors.lastname: Polonifi
authors.affiliation: First Department of Medicine, "Laiko" General Hospital, University of Athens, Medical School, Athens, Greece.
authors.forename: Aristeidis G
authors.initials: AG
authors.lastname: Vaiopoulos
authors.affiliation: First Department of Medicine, "Laiko" General Hospital, University of Athens, Medical School, Athens, Greece.
authors.forename: Aristidis
authors.initials: A
authors.lastname: Polyzos
authors.affiliation: First Department of Medicine, "Laiko" General Hospital, University of Athens, Medical School, Athens, Greece.
authors.forename: Marina
authors.initials: M
authors.lastname: Mantzourani
mesh_terms: D063646:Carcinogenesis; D002455:Cell Division / Q000502:physiology; D019008:Drug Resistance, Neoplasm; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology / Q000532:radiotherapy; D000077022:Survivin
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin
keywords: Anti-apoptotic protein; Cancer; IAP family; Survivin; Targeted therapy