title: Capacity for infectious HIV-1 virion capture differs by envelope antibody specificity.
abstract: Antibody capacity to recognize infectious virus is a prerequisite of many antiviral functions. We determined the infectious virion capture index (IVCI) of different antibody specificities. Whereas broadly neutralizing antibodies (bNAbs), except for an MPER bNAb, selectively captured infectious virions, non-bNAbs and mucosal human immunodeficiency virus type 1 (HIV-1)-positive IgG captured subsets of both infectious and noninfectious virions. Infectious virion capture was additive with a mixture of antibodies, providing proof of concept for vaccine-induced antibodies that together have improved capacity to recognize infectious virions.
authors.affiliation: Duke Human Vaccine Institute, Duke University, Durham, North Carolina, USA.
authors.forename: Pinghuang
authors.initials: P
authors.lastname: Liu
authors.forename: Latonya D
authors.initials: LD
authors.lastname: Williams
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Shen
authors.forename: Mattia
authors.initials: M
authors.lastname: Bonsignori
authors.forename: Nathan A
authors.initials: NA
authors.lastname: Vandergrift
authors.forename: R Glenn
authors.initials: RG
authors.lastname: Overman
authors.forename: M Anthony
authors.initials: MA
authors.lastname: Moody
authors.forename: Hua-Xin
authors.initials: HX
authors.lastname: Liao
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Stieh
authors.forename: Kerrie L
authors.initials: KL
authors.lastname: McCotter
authors.forename: Audrey L
authors.initials: AL
authors.lastname: French
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Hope
authors.forename: Robin
authors.initials: R
authors.lastname: Shattock
authors.forename: Barton F
authors.initials: BF
authors.lastname: Haynes
authors.forename: Georgia D
authors.initials: GD
authors.lastname: Tomaras
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D057134:Antibodies, Neutralizing / Q000276:immunology; D000918:Antibody Specificity; D005260:Female; D015483:HIV Antibodies / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology* / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000276:immunology; D054299:env Gene Products, Human Immunodeficiency Virus / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies; D007074:Immunoglobulin G; D054299:env Gene Products, Human Immunodeficiency Virus