title: 'Residence is not home' is a particular type of delusion associated with cognitive decline of Alzheimer's disease.
abstract: BACKGROUND
  Although delusion is one of the common symptoms of Alzheimer's disease (AD), the association between cognitive deficits and delusions remains unclear. Considering the heterogeneity of delusion, the correlation may depend upon the type of the delusion.
  
  
  METHODS
  142 consecutive first-visit AD outpatients of the Tajiri Clinic (Osaki, Miyagi, Japan) were enrolled in the study. Psychological data included the Mini-Mental State Examination (MMSE), the Cognitive Abilities Screening Instrument (CASI) and the Frequency-Weighted Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD-FW). Correlations to cognitive deficits for each category of delusional content were evaluated.
  
  
  RESULTS
  More severe delusion of 'residence is not home' was significantly correlated with a lower total MMSE score and poorer orientation as assessed with the CASI. This type of delusion also correlated to activity disturbances and was weakly associated with affective disturbances.
  
  
  CONCLUSIONS
  Our findings suggest that the 'residence is not home' delusion is a particular symptom that has a cognitive background, particularly disorientation, and should be discriminated from other delusional phenomena. We should cope with delusions specifying what types of delusions are present since the content of delusions may critically mark the symptomatology of AD. For this purpose, the BEHAVE-AD-FW may be suitable.
authors.affiliation: Department of Geriatric Behavioral Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakatsuka
authors.forename: Kenichi
authors.initials: K
authors.lastname: Meguro
authors.forename: Kei
authors.initials: K
authors.lastname: Nakamura
authors.forename: Kyoko
authors.initials: K
authors.lastname: Akanuma
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamaguchi
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology / Q000523:psychology; D003702:Delusions / Q000175:diagnosis / Q000209:etiology / Q000523:psychology; D005260:Female; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D009483:Neuropsychological Tests; D010045:Outpatients / Q000523:psychology / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011618:Psychotic Disorders / Q000175:diagnosis / Q000209:etiology / Q000523:psychology; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D013223:Statistics as Topic