title: Secondary use of clinical data: the Vanderbilt approach.
abstract: The last decade has seen an exponential growth in the quantity of clinical data collected nationwide, triggering an increase in opportunities to reuse the data for biomedical research. The Vanderbilt research data warehouse framework consists of identified and de-identified clinical data repositories, fee-for-service custom services, and tools built atop the data layer to assist researchers across the enterprise. Providing resources dedicated to research initiatives benefits not only the research community, but also clinicians, patients and institutional leadership. This work provides a summary of our approach in the secondary use of clinical data for research domain, including a description of key components and a list of lessons learned, designed to assist others assembling similar services and infrastructure.
authors.affiliation: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States; Department of Biomedical Informatics, Vanderbilt University Medical Center, 2209 Garland Ave., Nashville, TN 37232, United States. Electronic address: Ioana.danciu@vanderbilt.edu.
authors.forename: Ioana
authors.initials: I
authors.lastname: Danciu
authors.affiliation: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
authors.forename: James D
authors.initials: JD
authors.lastname: Cowan
authors.affiliation: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
authors.forename: Melissa
authors.initials: M
authors.lastname: Basford
authors.affiliation: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wang
authors.affiliation: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
authors.forename: Alexander
authors.initials: A
authors.lastname: Saip
authors.affiliation: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
authors.forename: Susan
authors.initials: S
authors.lastname: Osgood
authors.affiliation: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
authors.forename: Jana
authors.initials: J
authors.lastname: Shirey-Rice
authors.affiliation: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States.
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Kirby
authors.affiliation: Vanderbilt Institute for Clinical and Translational Research, Vanderbilt University Medical Center, 2525 West End Ave., 6th Floor, Nashville, TN 37203, United States; Department of Biomedical Informatics, Vanderbilt University Medical Center, 2209 Garland Ave., Nashville, TN 37232, United States.
authors.forename: Paul A
authors.initials: PA
authors.lastname: Harris
mesh_terms: D035843:Biomedical Research / Q000379:methods*; D003628:Database Management Systems; D057286:Electronic Health Records; D006801:Humans; D008490:Medical Informatics / Q000379:methods*
keywords: Biomedical informatics; Research data warehouse; Research enterprise; Secondary use of clinical data