title: Interstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance.
abstract: Glucose-insulin system models are commonly used for identifying insulin sensitivity. With physiological, 2-compartment insulin kinetics models, accurate kinetic parameter values are required for reliable estimates of insulin sensitivity. This study uses data from 6 published microdialysis studies to determine the most appropriate parameter values for the transcapillary diffusion rate (n(I)) and cellular insulin clearance rate (n(C)). The 6 studies (12 data sets) used microdialysis techniques to simultaneously obtain interstitial and plasma insulin concentrations. The reported plasma insulin concentrations were used as input and interstitial insulin concentrations were simulated with the interstitial insulin kinetics sub-model. These simulated results were then compared to the reported interstitial measurements and the most appropriate set of parameter values was determined across the 12 data sets by combining the results. Interstitial insulin kinetic parameters values n(I)=n(C)=0.0060 min⁻¹ were shown to be the most appropriate. These parameter values are associated with an effective, interstitial insulin half-life, t(½)=58 min, within the range of 25-130 min reported by others.
authors.affiliation: University of Canterbury, Centre for Bioengineering, Christchurch, New Zealand. Electronic address: chris.pretty@canterbury.ac.nz.
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Pretty
authors.affiliation: University of Canterbury, Centre for Bioengineering, Christchurch, New Zealand. Electronic address: aaron.lecompte@canterbury.ac.nz.
authors.forename: Aaron
authors.initials: A
authors.lastname: Le Compte
authors.affiliation: University of Liege, GIGA-Cardiovascular Sciences, Liege, Belgium. Electronic address: sophie.penning@ulg.ac.be.
authors.forename: Sophie
authors.initials: S
authors.lastname: Penning
authors.affiliation: University of Canterbury, Centre for Bioengineering, Christchurch, New Zealand. Electronic address: liam.fisk@pg.canterbury.ac.nz.
authors.forename: Liam
authors.initials: L
authors.lastname: Fisk
authors.affiliation: Christchurch Hospital, Department of Intensive Care, Christchurch, New Zealand. Electronic address: geoff.shaw@cdhb.govt.nz.
authors.forename: Geoffrey M
authors.initials: GM
authors.lastname: Shaw
authors.affiliation: University of Liege, GIGA-Cardiovascular Sciences, Liege, Belgium. Electronic address: tdesaive@ulg.ac.be.
authors.forename: Thomas
authors.initials: T
authors.lastname: Desaive
authors.affiliation: University of Canterbury, Centre for Bioengineering, Christchurch, New Zealand. Electronic address: geoff.chase@canterbury.ac.nz.
authors.forename: J Geoffrey
authors.initials: JG
authors.lastname: Chase
mesh_terms: D000465:Algorithms; D001786:Blood Glucose / Q000737:chemistry; D003198:Computer Simulation; D045604:Extracellular Fluid / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood / Q000737:chemistry*; D007700:Kinetics; D017551:Microdialysis; D015203:Reproducibility of Results; D012984:Software; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin
keywords: Biomedical system modelling; Control of physiological and clinical variables; Simulation and visualisation