title: Vaccination against Alzheimer disease: an update on future strategies.
abstract: Alzheimer disease is a devastating chronic disease without adequate therapy. More than 10 years ago, it was demonstrated in transgenic mouse models that vaccination may be a novel, disease-modifying therapy for Alzheimer. Subsequent clinical development has been a roller-coaster with some positive and many negative news. Here, we would like to summarize evidence that next generation vaccines optimized for old people and focusing on patients with mild disease stand a good chance to proof efficacious for the treatment of Alzheimer.
authors.affiliation: Saiba GmbH; Rämismühle, Switzerland; Dermataology; University Hospital of Zürich; Zürich, Switzerland.
authors.forename: Antonia
authors.initials: A
authors.lastname: Fettelschoss
authors.affiliation: Saiba GmbH; Rämismühle, Switzerland; Dermataology; University Hospital of Zürich; Zürich, Switzerland.
authors.forename: Franziska
authors.initials: F
authors.lastname: Zabel
authors.affiliation: Dermataology; University Hospital of Zürich; Zürich, Switzerland; The Jenner Institute; University of Oxford; Oxfordshire, UK.
authors.forename: Martin F
authors.initials: MF
authors.lastname: Bachmann
mesh_terms: D000544:Alzheimer Disease / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy*; D023582:Alzheimer Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D000818:Animals; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D008822:Mice, Transgenic; D016896:Treatment Outcome; D014611:Vaccination / Q000379:methods*
chemical_list: D023582:Alzheimer Vaccines
keywords: Abeta; Alzheimer; antibody; third generation; vaccine