title: Plasma insulin, glucose, IGF-I, IGF-II, and IGFBP-3 and risk of recurrent colorectal adenomas.
abstract: OBJECTIVE
  Insulin and insulin-like growth factors (IGF's) are associated with an increased risk of colorectal adenomas. The association with recurrent adenomas is inadequately studied. We prospectively examined the relationship between insulin biomarkers and the risk of recurrent adenomas.
  
  
  METHODS
  Our analysis included 167 subjects with one or more adenomas detected on a baseline colonoscopy who had a surveillance colonoscopy within three to five years. We measured serum biomarkers in all subjects at baseline. ELISA was used to measure fasting plasma insulin, IGF-I, IGF-II, and IGF binding protein-3. The hexokinase assay was used to measure fasting plasma glucose by and immuno-turbidimetric assay to measure hemoglobin A1C.
  
  
  RESULTS
  Subjects with recurrent adenomas were more likely to be male, overweight and have ≥3 adenomas at baseline. We found no significant associations between insulin (OR=1.6, 95% CI 0.7-3.5), glucose (OR=1.4, 95% CI 0.7-3.1), IGF-I (OR=0.7, 95% CI 0.3-1.5), IGF-II (OR=1.0, 95% CI 0.5-2.3), IGFBP-3 (OR=0.1, 95% CI 0.5-2.1), or anthropometric measures and recurrent adenomas.
  
  
  CONCLUSIONS
  Our results do not support a role for insulin biomarkers and recurrent colorectal adenomas.
authors.affiliation: Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC.
authors.forename: Melissa
authors.initials: M
authors.lastname: Kang
authors.affiliation: Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC.
authors.forename: Anne F
authors.initials: AF
authors.lastname: Peery
authors.affiliation: School of Medicine, University of North Carolina, Chapel Hill, NC.
authors.forename: Cameron
authors.initials: C
authors.lastname: Locklear
authors.affiliation: Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Galanko
authors.affiliation: Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Sandler
authors.affiliation: Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC.
authors.forename: Temitope O
authors.initials: TO
authors.lastname: Keku
keywords: colorectal adenoma; insulin; insulin-like growth factor