title: Role of chemokines in proteinuric kidney disorders.
abstract: Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent progress in cellular and molecular understanding of the role of chemokines in the pathogenesis of proteinuria-induced renal injury, as well as their clinical implications and therapeutic potential.
authors.affiliation: Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain.
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Moreno
authors.affiliation: Department of Biotechnology, INIA, Madrid, Spain.
authors.forename: Sara
authors.initials: S
authors.lastname: Moreno
authors.affiliation: Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Rubio-Navarro
authors.affiliation: Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Gómez-Guerrero
authors.affiliation: Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Ortiz
authors.affiliation: Department of Nephrology, IIS-Fundación Jiménez Díaz, Autonoma University, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Egido
mesh_terms: D000818:Animals; D018925:Chemokines / Q000037:antagonists & inhibitors / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D009393:Nephritis / Q000178:diet therapy / Q000276:immunology* / Q000378:metabolism; D011507:Proteinuria / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D019707:Receptors, Chemokine / Q000502:physiology
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine