title: Transcriptional regulation of wound inflammation.
abstract: The attraction and activation of immune cells is an important response of the skin to injury and allows an efficient defense against invading pathogens. In addition, immune cells fulfill various functions that are important for the repair process. An exaggerated inflammatory response, however, is a hallmark of chronic, non-healing wounds. Therefore, it is essential to strictly control and coordinate the levels and activities of various immune cells in normal and wounded skin. Recent studies provided insight into the molecular mechanisms underlying the inflammatory response after wounding, and various transcriptional regulators involved in this process have been identified. This review summarizes our current knowledge on the function of different transcription factors in wound repair, with particular emphasis on proteins with a documented role in the control of wound inflammation.
authors.affiliation: Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, CH 8093 Zurich, Switzerland.
authors.forename: Eric
authors.initials: E
authors.lastname: Haertel
authors.affiliation: Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, CH 8093 Zurich, Switzerland. Electronic address: sabine.werner@biol.ethz.ch.
authors.forename: Sabine
authors.initials: S
authors.lastname: Werner
authors.affiliation: Institute of Molecular Health Sciences, Department of Biology, Swiss Federal Institute of Technology (ETH) Zurich, CH 8093 Zurich, Switzerland.
authors.forename: Matthias
authors.initials: M
authors.lastname: Schäfer
mesh_terms: D000818:Animals; D001777:Blood Coagulation; D005786:Gene Expression Regulation; D007249:Inflammation / Q000235:genetics* / Q000276:immunology; D051379:Mice; D012867:Skin / Q000293:injuries; D014158:Transcription, Genetic; D014945:Wound Healing
keywords: Granulation tissue; Inflammation; Scar; Transcription factor