title: Hypolipidemic activity of Phellinus rimosus against triton WR-1339 and high cholesterol diet induced hyperlipidemic rats.
abstract: Patients with the risk for atherosclerotic disease will be targeted to reduce the existing hyperlipidemia. The hypolipidemic activity of Phellinus rimosus was studied using triton WR-1339 and high cholesterol diet (HCD) induced models. The triton induced elevated lipid profile was attenuated by P. rimosus or standard drug atorvastatin. Similarly, administration of P. rimosus along with HCD significantly decline serum triglyceride, total cholesterol, low-density lipoprotein, with elevating the high-density lipoprotein. Thiobarbituric acid reacting substances in heart and liver significantly decreased; where as activity of enzymatic antioxidants and level of reduced glutathione were significantly increased. In both models, P. rimosus extract showed a significant ameliorative effect on the elevated atherogenic index as well as LDL/HDL-C ratio. The hypolipidemic activity of P. rimosus can be ascribed to its inhibitory effect on the liver HMG CoA reductase activity. The results suggest the possible therapeutic potential of this fungus as hypolipidemic agent.
authors.affiliation: Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala, India.
authors.forename: K A
authors.initials: KA
authors.lastname: Rony
authors.affiliation: Department of Biochemistry, Amala Institute of Medical Sciences, Amala Nagar, Thrissur 680555, Kerala, India.
authors.forename: T A
authors.initials: TA
authors.lastname: Ajith
authors.affiliation: Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala, India.
authors.forename: N
authors.initials: N
authors.lastname: Nima
authors.affiliation: Department of Microbiology, Amala Cancer Research Centre, Amala Nagar, Thrissur 680555, Kerala, India. Electronic address: drkkjanardhanan@gmail.com.
authors.forename: K K
authors.initials: KK
authors.lastname: Janardhanan
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001487:Basidiomycota; D045424:Complex Mixtures / Q000494:pharmacology / Q000627:therapeutic use*; D059305:Diet, High-Fat; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011092:Polyethylene Glycols; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D045424:Complex Mixtures; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D011092:Polyethylene Glycols; D006903:Hydroxymethylglutaryl CoA Reductases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; C016811:tyloxapol
keywords: Antioxidant status; Atherogenic index; Hypolipidemic effect; Lipid profile; Phellinus rimosus; Triton WR-1339