title: Adsorption and desorption behaviors of selected endocrine disrupting chemicals in simulated gastrointestinal fluids.
abstract: An in vitro technique using simulated gastrointestinal (GI) fluids was applied to investigate the desorption of selected endocrine disrupting chemicals (EDCs), i.e. bisphenol A (BPA) and 17 α-ethinylestradiol (EE2), from the marine sediment in the digestive environment. The results show that the GI fluids suppressed chemical adsorption and greatly increased the desorption of BPA and EE2 from the sediment. Pepsin in the gastric fluid would compete for the adsorption sites with the adsorbates, and bile salts in the intestinal fluid had a solubilization effect on the chemicals. The amount of chemical release from the sediment in different fluids followed intestinal (fed)>intestinal (fasted)>gastric>saline water. During the dynamic desorption tests, 62% and 21% of sediment-bound BPA and EE2, respectively, could be released into the simulated GI fluids. The enhanced desorption of EDCs from sediment in the digestive system would make the pollutants more bioavailable in the ecosystem.
authors.affiliation: Environmental Engineering Research Centre, Department of Civil Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China; Guangzhou Institute of Advanced Technology, Chinese Academy of Sciences, Guangzhou, China.
authors.forename: Ying-heng
authors.initials: YH
authors.lastname: Fei
authors.affiliation: The Swire Institute of Marine Science and School of Biological Sciences, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Kenneth M Y
authors.initials: KM
authors.lastname: Leung
authors.affiliation: Environmental Engineering Research Centre, Department of Civil Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China. Electronic address: xlia@hkucc.hku.hk.
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Li
mesh_terms: D000327:Adsorption; D001559:Benzhydryl Compounds / Q000032:analysis / Q000737:chemistry*; D052244:Endocrine Disruptors / Q000032:analysis / Q000737:chemistry*; D004997:Ethinyl Estradiol / Q000032:analysis / Q000737:chemistry*; D005766:Gastrointestinal Contents / Q000737:chemistry; D019015:Geologic Sediments / Q000737:chemistry; D010636:Phenols / Q000032:analysis / Q000737:chemistry*; D014867:Water; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000737:chemistry*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004997:Ethinyl Estradiol; D010636:Phenols; D014867:Water; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: 17 α-Ethinylestradiol (EE2); Adsorption; Bisphenol A (BPA); Desorption; Gastrointestinal fluids; Marine sediment