title: Body mass index and myocardium at risk in patients with acute coronary syndrome.
abstract: OBJECTIVE
  Whilst traditional studies have shown that obese individuals are at a higher risk of cardiovascular events compared to lean subjects, recent studies in patients with acute myocardial infarction (AMI) have suggested that obesity may exert protective effects (the "obesity paradox"). We sought to assess the relationship between body mass index (BMI) and the BARI score (BARIsc), a validated tool used to assess myocardium at risk, in patients with acute coronary syndrome.
  
  
  METHODS
  Participants were 116 consecutive patients (mean age, 60.6 years; 97 men) with AMI (68 ST elevated myocardial infarction, STEMI; 48 non-ST elevated myocardial infarction, NSTEMI). Demographics, BMI, risk factors, biochemistry data, left ventricular function, angiographic data and the BARIsc were assessed in every patient.
  
  
  RESULTS
  Multiple linear regression analyses showed that BMI significantly correlated with BARIsc; β=.23, p<0.02. This was found only in the overweight/obese patients, β=.27, p<0.01, but not in patients with normal BMIs, β=0.08, p=0.71.
  
  
  CONCLUSIONS
  An increased body weight is associated with an increased area of myocardium at risk in patients with ACS.
authors.affiliation: Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain; Cardiovascular Sciences Research Centre, St George's University of London, London, United Kingdom. Electronic address: alam_1981@hotmail.com.
authors.forename: A L
authors.initials: AL
authors.lastname: Arrebola-Moreno
authors.affiliation: Department of Experimental Psychology, University of Granada, Granada, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Marfil-Alvarez
authors.affiliation: Department of Experimental Psychology, University of Granada, Granada, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Catena
authors.affiliation: Department of Experimental Psychology, University of Granada, Granada, Spain.
authors.forename: R
authors.initials: R
authors.lastname: García-Retamero
authors.affiliation: Department of Experimental Psychology, University of Granada, Granada, Spain.
authors.forename: J P
authors.initials: JP
authors.lastname: Arrebola
authors.affiliation: Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Melgares-Moreno
authors.affiliation: Cardiology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Ramirez-Hernández
authors.affiliation: Cardiovascular Sciences Research Centre, St George's University of London, London, United Kingdom.
authors.forename: J C
authors.initials: JC
authors.lastname: Kaski
mesh_terms: D054058:Acute Coronary Syndrome / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D009765:Obesity / Q000453:epidemiology*; D050177:Overweight / Q000453:epidemiology*; D012307:Risk Factors
keywords: Acute coronary syndrome; Acute myocardial infarction; BARI score; Infarto agudo de miocardio; Obesity paradox; Paradoja de la obesidad; Puntuación BARI; Síndrome coronario agudo