title: Acute kidney injury after transcatheter aortic valve implantation: incidence, predictors and impact on mortality.
abstract: There is a paucity of data describing acute kidney injury (AKI) following transcatheter aortic valve implantation and its impact on mortality remains unknown. We therefore evaluate the incidence, predictors and impact of AKI following transcatheter aortic valve implantation. We searched MEDLINE for studies from 2008 to 2013, evaluating AKI after transcatheter aortic valve implantation. All studies were compared according to the incidence, predictors and impact of AKI following transcatheter aortic valve implantation. AKI was diagnosed according to the Valve Academic Research Consortium definition using the RIFLE criteria. Thirteen studies with more than 1900 patients were included. AKI occurred in 8.3-57% of the patients. The following factors were associated with AKI: blood transfusion; transapical access; preoperative creatinine concentration; peripheral vascular disease; hypertension; and procedural bleeding events. The 30-day mortality rate in patients with AKI ranged from 13.3% to 44.4% and was 2-6-fold higher than in patients without AKI. The amount of contrast agent used was not associated with the occurrence of AKI. AKI is a common complication, with an incidence of 8.3-57% following transcatheter aortic valve implantation. Patients with AKI had higher 30-day and late mortality rates. However, AKI was related to the amount of contrast volume used in only one study.
authors.affiliation: Clinic for Cardiovascular Surgery, German Heart Centre, Munich, Germany. Electronic address: elhmidi@yahoo.com.
authors.forename: Yacine
authors.initials: Y
authors.lastname: Elhmidi
authors.affiliation: Clinic for Cardiovascular Surgery, German Heart Centre, Munich, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Bleiziffer
authors.affiliation: Clinic for Cardiovascular Surgery, German Heart Centre, Munich, Germany.
authors.forename: Marcus-André
authors.initials: MA
authors.lastname: Deutsch
authors.affiliation: Clinic for Cardiovascular Surgery, German Heart Centre, Munich, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Krane
authors.affiliation: Clinic for Cardiovascular Surgery, German Heart Centre, Munich, Germany.
authors.forename: Domenico
authors.initials: D
authors.lastname: Mazzitelli
authors.affiliation: Clinic for Cardiovascular Surgery, German Heart Centre, Munich, Germany.
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Lange
authors.affiliation: Clinic for Cardiovascular Surgery, German Heart Centre, Munich, Germany; Department of Interventional Cardiology, McGill University Health Centre, Montreal, Quebec, Canada.
authors.forename: Nicolo
authors.initials: N
authors.lastname: Piazza
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D006328:Cardiac Catheterization / Q000009:adverse effects* / Q000401:mortality; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects* / Q000379:methods / Q000401:mortality; D006801:Humans; D015994:Incidence; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors
keywords: Acute kidney injury; Critères RIFLE; Insuffisance rénale aiguë; L’implantation des valves aortiques par voie percutanée; RIFLE criteria; TAVR