title: Evaluating systems pharmacology models is different from evaluating standard pharmacokinetic-pharmacodynamic models.
abstract: Based on the author's recent experience, there appears to be some confusion regarding the steps required to qualify a systems pharmacology model as adequate for the intended purpose. This manuscript outlines the model evaluation approach used in the author's recent publication(1) on the systems pharmacology of a 5-lipoxygenase inhibitor and is an attempt to generate discussion on this topic within the pharmacometrics and systems pharmacology community.
authors.affiliation: MedImmune LLC, Clinical Pharmacology, Drug Metabolism, and Pharmacokinetics, Cambridge, UK.
authors.forename: B
authors.initials: B
authors.lastname: Agoram