title: Orbital extra-medullary granulocytic sarcoma: clinicopathologic correlation with immunohistochemical features.
abstract: Orbital granulocytic sarcoma (chloroma), a rare tumor of immature myeloid cells, has nonspecific clinical and radiological features that make it a diagnostic challenge. Light microscopy and confirmation by immunostaining aid in the diagnosis. Knowledge of this entity is important because early diagnosis and prompt treatment are associated with better prognosis. We report a series of 31 biopsy-proven orbital granulocytic sarcomas with their immunohistochemical features and review the literature.
authors.affiliation: Department of Oculoplastics and Ocular Oncology, Vasan Eye Care and L.V. Prasad Eye Institute, Hyderabad, India. Electronic address: drektaoph@gmail.com.
authors.forename: Ekta
authors.initials: E
authors.lastname: Aggarwal
authors.affiliation: National Reporting Centre for Ophthalmic Pathology, Centre for Sight, Hyderabad and Department of Ophthalmic Pathology, L.V. Prasad Eye Institute, Hyderabad, India.
authors.forename: Kaustubh
authors.initials: K
authors.lastname: Mulay
authors.affiliation: Department of Oculoplasty and Ocular Oncology, Centre for Sight, Hyderabad, and L.V. Prasad Eye Institute, Hyderabad, India.
authors.forename: Santosh G
authors.initials: SG
authors.lastname: Honavar
mesh_terms: D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000378:metabolism / Q000473:pathology; D023981:Sarcoma, Myeloid / Q000378:metabolism / Q000473:pathology; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor
keywords: chloroma; extramedullary; granulocytic sarcoma; leukemia; orbit