title: Sex differences in stroke: the contribution of coagulation.
abstract: Stroke is now the leading cause of adult disability in the United States. Women are disproportionately affected by stroke. Women increasingly outnumber men in the elderly population, the period of highest risk for stroke. However, there is also a growing recognition that fundamental sex differences are present that contribute to differential ischemic sensitivity. In addition, gonadal hormone exposure can impact coagulation and fibrinolysis, key factors in the initiation of thrombosis. In this review we will discuss sex differences in stroke, with a focus on platelets, vascular reactivity and coagulation.
authors.affiliation: University of Connecticut Health Center, School of Medicine, USA.
authors.forename: Meaghan
authors.initials: M
authors.lastname: Roy-O'Reilly
authors.affiliation: University of Connecticut Health Center, School of Medicine, USA; The Stroke Center at Hartford Hospital, USA. Electronic address: lmccullough@uchc.edu.
authors.forename: Louise D
authors.initials: LD
authors.lastname: McCullough
mesh_terms: D001777:Blood Coagulation / Q000235:genetics* / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000235:genetics / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000235:genetics / Q000502:physiology; D002877:Chromosomes, Human / Q000235:genetics / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D012727:Sex Characteristics; D020521:Stroke / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D015912:Thrombolytic Therapy
chemical_list: D001779:Blood Coagulation Factors
keywords: Cerebral ischemia; Estrogen; Thrombosis; Vasculature; Women