title: Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy.
abstract: Alterations to brain homeostasis during development are reflected in the neurochemical profile determined noninvasively by (1)H magnetic resonance spectroscopy. We determined longitudinal biochemical modifications in the cortex, hippocampus, and striatum of C57BL/6 mice aged between 3 and 24 months . The regional neurochemical profile evolution indicated that aging induces general modifications of neurotransmission processes (reduced GABA and glutamate), primary energy metabolism (altered glucose, alanine, and lactate) and turnover of lipid membranes (modification of choline-containing compounds and phosphorylethanolamine), which are all probably involved in the frequently observed age-related cognitive decline. Interestingly, the neurochemical profile was different in male and female mice, particularly in the levels of taurine that may be under the control of estrogen receptors. These neurochemical profiles constitute the basal concentrations in cortex, hippocampus, and striatum of healthy aging male and female mice.
authors.affiliation: Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Department of Radiology, University of Lausanne, Lausanne, Switzerland. Electronic address: joao.duarte@epfl.ch.
authors.forename: João M N
authors.initials: JM
authors.lastname: Duarte
authors.affiliation: Department of Psychiatry, Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland.
authors.forename: Kim Q
authors.initials: KQ
authors.lastname: Do
authors.affiliation: Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Department of Radiology, University of Lausanne, Lausanne, Switzerland; Department of Radiology, University of Geneva, Geneva, Switzerland.
authors.forename: Rolf
authors.initials: R
authors.lastname: Gruetter
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000523:psychology; D000409:Alanine / Q000378:metabolism; D000818:Animals; D002540:Cerebral Cortex / Q000737:chemistry* / Q000378:metabolism*; D003071:Cognition; D003342:Corpus Striatum / Q000737:chemistry* / Q000378:metabolism*; D004734:Energy Metabolism; D004983:Ethanolamines / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism; D006624:Hippocampus / Q000737:chemistry* / Q000378:metabolism*; D006859:Hydrogen; D007773:Lactates / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D011960:Receptors, Estrogen / Q000502:physiology; D012727:Sex Characteristics; D009435:Synaptic Transmission; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D004983:Ethanolamines; D007773:Lactates; D008563:Membrane Lipids; D011960:Receptors, Estrogen; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; C005448:phosphorylethanolamine; D006859:Hydrogen; D005947:Glucose; D000409:Alanine
keywords: (1)H MRS; Aging; Biomarkers; Brain; Metabolism; Neurochemical profile