title: The immune response in HPV+oropharyngeal cancer.
abstract: Although human papillomavirus (HPV)+oropharyngeal cancers often present with metastasis, most patients have excellent long-term survival. The reason underlying such an apparent contradiction remains unclear, but we have recently demonstrated that the improved survival of HPV+oropharyngeal cancer patients has an immunological component, as the levels of tumor-infiltrating lymphocytes (TILs) can be used to stratify HPV+patients into high-risk and low-risk groups.
authors.affiliation: Cancer Sciences Unit; University of Southampton; Southampton, UK ; Department of Otolaryngology; Head and Neck Surgery; Poole NHS Foundation Trust; Poole, UK.
authors.forename: Emma V
authors.initials: EV
authors.lastname: King
authors.affiliation: Cancer Sciences Unit; University of Southampton; Southampton, UK ; NIHR Experimental Cancer Medicine Centre Southampton; Southampton, UK.
authors.forename: Christian H
authors.initials: CH
authors.lastname: Ottensmeier
authors.affiliation: Cancer Sciences Unit; University of Southampton; Southampton, UK ; NIHR Experimental Cancer Medicine Centre Southampton; Southampton, UK.
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Thomas
keywords: human papillomavirus; oropharyngeal cancer; prognosis; survival; tumor-infiltrating lymphocytes