title: Concomitant use of argatroban and warfarin during hemodialysis in heparin-induced thrombocytopenia.
abstract: OBJECTIVE
  The use of argatroban during hemodialysis in a patient receiving warfarin is not established. We present a case of heparin-induced thrombocytopenia in a patient on hemodialytic therapy who successfully received argatroban concomitantly to warfarin during renal replacement therapy.
  
  
  METHODS
  A 46-year-old male patient with autosomal dominant polycystic kidney disease presented with heparin-induced thrombocytopenia (HIT) arised during dialytic procedures. Intervention After the acute episode requiring argatroban and warfarin therapy, the patient continued to receive argatroban during the hemodialytic session concomitantly to warfarin.
  
  
  CONCLUSIONS
  The administration of argatroban in the dialytic circuit of a patient on oral anticoagulant therapy can be considered an effective and safe approach.
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vianello
authors.forename: Lucrezia
authors.initials: L
authors.lastname: Furian
authors.forename: Maurizio
authors.initials: M
authors.lastname: Nordio
authors.forename: Martina
authors.initials: M
authors.lastname: Treleani
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Fabris
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage*; D001120:Arginine / Q000031:analogs & derivatives; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010875:Pipecolic Acids / Q000008:administration & dosage*; D007690:Polycystic Kidney Diseases / Q000097:blood / Q000628:therapy; D006435:Renal Dialysis / Q000379:methods*; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced / Q000188:drug therapy*; D014859:Warfarin / Q000008:administration & dosage*
chemical_list: D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D014859:Warfarin; D006493:Heparin; D001120:Arginine; C031942:argatroban
keywords: Argatroban; Hemodialysis; Heparin-induced thrombocytopenia