title: Synthesis of antimicrobial cyclodextrins bearing polyarylamino and polyalkylamino groups via click chemistry for bacterial membrane disruption.
abstract: Cyclodextrin derivatives are synthesized as membrane-disrupting agents via a microwave-assisted Huisgen reaction. Their ability to permeabilize bacterial membranes depends on the amino substituents and an appropriate balance of hydrophobicity and hydrophilicity, thus enabling the preparation of derivatives with selective toxicity against bacteria.
authors.affiliation: Graduate School of Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan. yamamura.hatsuo@nitech.ac.jp.
authors.forename: Hatsuo
authors.initials: H
authors.lastname: Yamamura
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Kensuke
authors.initials: K
authors.lastname: Murata
authors.forename: Takanori
authors.initials: T
authors.lastname: Yokoi
authors.forename: Ryuji
authors.initials: R
authors.lastname: Kurata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyagawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Komagoe
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Takashi
authors.initials: T
authors.lastname: Katsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects*; D057930:Click Chemistry; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000166:cytology / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000166:cytology / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003505:Cyclodextrins