title: Salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy.
abstract: Our aim was to evaluate the feasibility of salvage operations for patients with persistent or recurrent cancer of the maxillary sinus after superselective intra-arterial infusion of cisplatin with concurrent radiotherapy. We retrospectively analysed the records of 61 patients with cancer of the maxillary sinus who were treated in this way. Chemotherapy comprised 100-120 mg/m(2) superselective intra-arterial infusions of cisplatin given a median of 4 times weekly (range 2-5). Concurrent radiotherapy was given in a median dose of 65 Gy (range 24-70 Gy). Persistent or recurrent cancer of the maxillary sinus was found in 17 patients, of whom 11 had salvage surgery. The disease was controlled in 8 of the 11, and 7 of the 11 survived with no evidence of disease. Their 5-year overall survival was 61%. Two of the 11 developed serious operative complications. Salvage surgery for patients with persistent or recurrent cancer of the maxillary sinus treated by superselective chemoradiotherapy is both safe and successful. Salvage surgery is a good option when this sort of persistent or recurrent cancer is followed up after the regimen of chemoradiotherapy described.
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: t-sakashita@med.hokudai.ac.jp.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakashita
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: ak-homma@med.hokudai.ac.jp.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Homma
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: htkym@med.hokudai.ac.jp.
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Hatakeyama
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: skano@med.hokudai.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kano
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: mizumati@med.hokudai.ac.jp.
authors.forename: Takatsugu
authors.initials: T
authors.lastname: Mizumachi
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: jfuru@med.hokudai.ac.jp.
authors.forename: Jun
authors.initials: J
authors.lastname: Furusawa
authors.affiliation: Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: panacea-hok@umin.net.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshida
authors.affiliation: Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: Noriyuki.Fujima@mb9.seikyou.ne.jp.
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Fujima
authors.affiliation: Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: ronimaru@pop.med.hokudai.ac.jp.
authors.forename: Rikiya
authors.initials: R
authors.lastname: Onimaru
authors.affiliation: Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: tsuchi1205@gmail.com.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Tsuchiya
authors.affiliation: Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: kyasuda@med.hokudai.ac.jp.
authors.forename: Koichi
authors.initials: K
authors.lastname: Yasuda
authors.affiliation: Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: shirato@med.hokudai.ac.jp.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirato
authors.affiliation: Department of Otolaryngology, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan. Electronic address: fumisuke@hok-mc.hosp.go.jp.
authors.forename: Fumiyuki
authors.initials: F
authors.lastname: Suzuki
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Electronic address: safukuda@med.hokudai.ac.jp.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukuda
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000601:surgery* / Q000628:therapy; D002423:Cause of Death; D059248:Chemoradiotherapy / Q000379:methods*; D002945:Cisplatin / Q000008:administration & dosage*; D018572:Disease-Free Survival; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000601:surgery* / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery* / Q000628:therapy; D009367:Neoplasm Staging; D011183:Postoperative Complications; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D013530:Surgical Wound Infection / Q000209:etiology; D015996:Survival Rate; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin
keywords: Chemotherapy; Intra-arterial; Maxillary sinus cancer; Radiotherapy; Salvage surgery; Squamous cell carcinoma