title: Rapid identification of illegal synthetic adulterants in herbal anti-diabetic medicines using near infrared spectroscopy.
abstract: We created a rapid detection procedure for identifying herbal medicines illegally adulterated with synthetic drugs using near infrared spectroscopy. This procedure includes a reverse correlation coefficient method (RCCM) and comparison of characteristic peaks. Moreover, we made improvements to the RCCM based on new strategies for threshold settings. Any tested herbal medicine must meet two criteria to be identified with our procedure as adulterated. First, the correlation coefficient between the tested sample and the reference must be greater than the RCCM threshold. Next, the NIR spectrum of the tested sample must contain the same characteristic peaks as the reference. In this study, four pure synthetic anti-diabetic drugs (i.e., metformin, gliclazide, glibenclamide and glimepiride), 174 batches of laboratory samples and 127 batches of herbal anti-diabetic medicines were used to construct and validate the procedure. The accuracy of this procedure was greater than 80%. Our data suggest that this protocol is a rapid screening tool to identify synthetic drug adulterants in herbal medicines on the market.
authors.affiliation: National Institutes for Food and Drug Control, Beijing 100050, China.
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Feng
authors.affiliation: Shaoyang Institute for Drug Control of Hunan, Shaoyang 422000, China.
authors.forename: Deqing
authors.initials: D
authors.lastname: Lei
authors.affiliation: National Institutes for Food and Drug Control, Beijing 100050, China. Electronic address: hucq@nifdc.org.cn.
authors.forename: Changqin
authors.initials: C
authors.lastname: Hu
mesh_terms: D004340:Drug Contamination; D007004:Hypoglycemic Agents / Q000032:analysis*; D010946:Plants, Medicinal / Q000737:chemistry*; D012015:Reference Standards; D015203:Reproducibility of Results; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D007004:Hypoglycemic Agents
keywords: Adulterants; Herbal medicines; Near infrared spectroscopy; Reverse correlation coefficient method; Synthetic drugs