title: Lack of Clinical Benefit of Thromboprophylaxis in Patients Hospitalized in a Medical Unit Over a 10-year Span.
abstract: BACKGROUND
  Thromboprophylaxis for hospitalized patients with a high risk of venous thromboembolic events (VTEs) is strongly recommended but is not universally applied on medical units. Outside of randomized trials, there is minimal evidence that the usual medications reduce the incidence of clinically significant VTE.
  
  
  METHODS
  We conducted a retrospective cohort study including all patients admitted into a teaching medical unit during years 2001-2002, 2003-2004, 2005-2006, 2007-2008 and 2009-2010. Inclusion criteria for the analysis were having one or more risk factors for a VTE and no contraindication to thromboprophylaxis.
  
  
  RESULTS
  Of 2,369 patients reviewed, 1,302 satisfied the inclusion criteria. Between years 2001-2002 and 2009-2010, the proportion of patients receiving thromboprophylaxis increased from 29.2% to 76.4% (P < 0.0001) and the duration of thromboprophylaxis increased from 63% of hospital stay to 84% (P = 0.004). There was no statistically significant association between the number of risk factors and the rate of thromboprophylaxis. Overall, only 32 patients suffered from a VTE with no decrease in VTE incidence between years 2001-2002 and 2009-2010. A total of 107 patients had a bleeding event, and there was no statistically significant change in the incidence of bleeding during our study period.
  
  
  CONCLUSIONS
  In our medical units, we found a statistically significant increase in the use of the thromboprophylaxis practice. However, this was not associated with any statistically significant impact on the VTE incidence. This suggests that patients given thromboprophylaxis could be better selected.
authors.affiliation: Centre Hospitalier de l'Universite de Montreal, Canada.
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Migner-Laurin
authors.affiliation: Faculte de Medecine de l'Universite de Montreal, Canada.
authors.forename: Thomas
authors.initials: T
authors.lastname: St-Aubin
authors.affiliation: Faculte de Medecine de l'Universite de Montreal, Canada.
authors.forename: Julie
authors.initials: J
authors.lastname: Lapointe
authors.affiliation: Centre Hospitalier de l'Universite de Montreal, Canada.
authors.forename: Paul
authors.initials: P
authors.lastname: Van Nguyen
authors.affiliation: Centre Hospitalier de l'Universite de Montreal, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Wistaff
authors.affiliation: Centre Hospitalier de l'Universite de Montreal, Canada.
authors.forename: Mikhael
authors.initials: M
authors.lastname: Laskin
authors.affiliation: Centre Hospitalier de l'Universite de Montreal, Canada.
authors.forename: Christophe
authors.initials: C
authors.lastname: Kolan
authors.affiliation: Centre Hospitalier de l'Universite de Montreal, Canada.
authors.forename: Maxime
authors.initials: M
authors.lastname: Lamarre-Cliche
keywords: Anticoagulation; Deep vein thrombosis; Hospital medicine; Pulmonary embolus; Thromboprophylaxis