title: Preparation of hemocompatible cellulosic paper based on P(DMAPS)-functionalized surface.
abstract: The surface-modification of paper substrates with functional layers is gaining increasing interest, both from academic and industrial research. In this case, the cellulosic paper (CP) surface was functionalized with zwitterionic poly-(3-dimethyl(methacryloyloxyethyl) ammoniumpropane sulfonate) (CP-g-P(DMAPS) via surface-initiated atom transfer radical polymerization (ATRP) technique for enhancing blood compatibility. An obvious increase in graft yield of the functional P(DMAPS) with polymerization time was observed. The new CP-g-P(DMAPS) produced was investigated for its hemocompatibility. The hemocompatibility studied including platelet and whole blood ceels adhesion tests, hemolysis assay, morphological changes of red blood cells (RBCs), coagulation time tests, and complement activation, platelet activation at the molecular level. Most assays had remarkable differences in the presence of the new zwitterionic CP, indicated the importance of the zwitterion for hemocompatibility of CP.
authors.affiliation: Jiangsu Key Lab of Pulping and Paper Science and Technology, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Lv
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Bingfeng
authors.initials: B
authors.lastname: Cai
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Youchao
authors.initials: Y
authors.lastname: Song
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China.
authors.forename: Haolin
authors.initials: H
authors.lastname: Zhao
authors.affiliation: Jiangsu Key Lab of Pulping and Paper Science and Technology, Nanjing Forestry University, Nanjing 210037, PR China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Jiang
authors.affiliation: Jiangsu Key Lab of Pulping and Paper Science and Technology, Nanjing Forestry University, Nanjing 210037, PR China. Electronic address: zxiaofan@njfu.com.cn.
authors.forename: Xiaofan
authors.initials: X
authors.lastname: Zhou
authors.affiliation: Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, PR China.
authors.forename: Ruide
authors.initials: R
authors.lastname: Yu
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China. Electronic address: maochun127@aliyun.com.
authors.forename: Chun
authors.initials: C
authors.lastname: Mao
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects; D002482:Cellulose / Q000737:chemistry*; D004912:Erythrocytes / Q000187:drug effects; D010209:Paper; D010316:Particle Size; D015539:Platelet Activation / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000187:drug effects; D011109:Polymethacrylic Acids / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D011817:Rabbits; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D011109:Polymethacrylic Acids; D000644:Quaternary Ammonium Compounds; D002482:Cellulose
keywords: ATRP; Cellulosic paper; Hemocompatibility; P(DMAPS); Surface modification