title: Modification of biomaterials with a self-protein inhibits the macrophage response.
abstract: A biomaterial inhibits the host immune response by displaying an endo-genously expressed immunomodulatory molecule, CD200. Immobilization of CD200 onto biomaterial surfaces effectively suppresses macrophage activation and reduces inflammatory response to subcutaneously implanted materials.
authors.affiliation: Department of Biomedical Engineering, University of California, Irvine, 2412 Engineering Hall, Irvine, CA, 92697-2730, USA; The Edwards Lifesciences Center for Advanced Cardiovascular Technology, University of California, Irvine, CA, 92697-2730, USA.
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Kim
authors.forename: Richard
authors.initials: R
authors.lastname: Que
authors.forename: Szu-Wen
authors.initials: SW
authors.lastname: Wang
authors.forename: Wendy F
authors.initials: WF
authors.lastname: Liu
mesh_terms: D000327:Adsorption; D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry*; D005260:Female; D006801:Humans; D055767:Immobilized Proteins / Q000737:chemistry / Q000494:pharmacology*; D007249:Inflammation; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D012867:Skin / Q000737:chemistry
chemical_list: D015703:Antigens, CD; D001672:Biocompatible Materials; D055767:Immobilized Proteins; C042739:antigens, CD200
keywords: biocompatibility; biomaterials; host response; immunomodulation