title: Association of knee osteoarthritis with onset and resolution of pain and physical functional disability: the ROAD study.
abstract: OBJECTIVE
  To examine the onset and resolution of pain and physical functional disability using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and their association with knee osteoarthritis (OA) in the longitudinal large-scale population of the nationwide cohort study, Research on Osteoarthritis/osteoporosis Against Disability (ROAD).
  
  
  METHODS
  Subjects from the ROAD study who had been recruited during 2005-2007 were followed up 3 years later. A total of 1,578 subjects completed the WOMAC questionnaire at baseline and follow up, and the onset and resolution rate of pain and physical functional disability were examined. We also examined the association of onset of pain and physical functional disability and their resolution with severity of knee OA as well as age, body-mass index and grip strength.
  
  
  RESULTS
  After a 3.3-year follow-up, the onset rate of pain was 35.0% and 35.3% in men and women, respectively, and the onset rate of physical functional disability was 38% and 40%, respectively. Resolution rate of pain was 20.3% and 26.2% in men and women, respectively, and resolution rate of physical functional disability was 16% and 14% in men and women, respectively. Knee OA was significantly associated with onset and resolution of pain and physical functional disability in women, but there was no significant association of knee OA with onset of pain and resolution of physical functional disability in men.
  
  
  CONCLUSIONS
  The present longitudinal study revealed the onset rate of pain and physical functional disability as well as their resolution, and their association with knee OA.
authors.affiliation: Department of Clinical Motor System Medicine, 22nd Century Medical & Research Center, Faculty of Medicine, the University of Tokyo , Tokyo , Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Muraki
authors.forename: Toru
authors.initials: T
authors.lastname: Akune
authors.forename: Keiji
authors.initials: K
authors.lastname: Nagata
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Ishimoto
authors.forename: Munehito
authors.initials: M
authors.lastname: Yoshida
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Tokimura
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D004185:Disability Evaluation; D006233:Persons with Disabilities; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000503:physiopathology*; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D010808:Physical Examination; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires
keywords: Epidemiology; Knee joint; Longitudinal studies; Osteoarthritis