title: Adiponectin as an independent predictor of left ventricular hypertrophy in nondiabetic patients with hypertension.
abstract: We evaluated novel and traditional biomarkers as well as hemodynamic parameters associated with the development of left ventricular hypertrophy (LVH) in nondiabetic patients with hypertension. Nondiabetic patients with hypertension (n = 86) were evaluated for lipids, glucose, insulin, homeostasis model assessment-insulin resistance (HOMA-IR), adiponectin, aldosterone, renin, matrix metalloproteinase 2, and endothelin. Arterial elasticity was evaluated using pulse wave contour. The LVH parameters were assessed echographically. Adiponectin was significantly and inversely associated with left ventricular mass (LVM; P = .032). The aldosterone-renin ratio (ARR) was significantly, positively associated with LVM (P = .031). Fasting insulin as well as HOMA-IR was significantly, positively associated with LVM (P = .036 and P = .025, respectively). In multiple linear regression analysis, adiponectin and ARR remained a significant predictor of LVM. The present study found that adiponectin and ARR are important independent determinants of LVH in nondiabetic patients with hypertension.
authors.affiliation: Department of Internal Medicine, Wolfson Medical Center, Holon, Israel.
authors.forename: Maya
authors.initials: M
authors.lastname: Peer
authors.affiliation: Department of Internal Medicine, Wolfson Medical Center, Holon, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Margarita
authors.initials: M
authors.lastname: Mashavi
authors.affiliation: Department of Biochemistry, Wolfson Medical Center, Holon, Israel.
authors.forename: Zipora
authors.initials: Z
authors.lastname: Matas
authors.affiliation: Department of Cardiology , Wolfson Medical Center, Holon, Israel.
authors.forename: David
authors.initials: D
authors.lastname: Harpaz
authors.affiliation: Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Endocrinology, Wolfson Medical Center, Holon, Israel marinas@wolfson.health.gov.il.
authors.forename: Marina
authors.initials: M
authors.lastname: Shargorodsky
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000450:Aldosterone / Q000097:blood; D015415:Biomarkers / Q000097:blood; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D063177:Pulse Wave Analysis; D012083:Renin / Q000097:blood; D012307:Risk Factors
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D000450:Aldosterone; D012083:Renin
keywords: adiponectin; aldosterone renin ratio; arterial compliance; left ventricular hypertrophy