title: The effects of lycopene on hepatic ischemia/reperfusion injury in rats.
abstract: There is a very little information about the protective effect of lycopene (LYC) against hepatic ischemia-reperfusion injury. The present study was designed to examine the possible protective effect of the strong antioxidant and anti-inflammatory agent, LYC, on hepatic ischemia/reperfusion injury. For this purpose, rats were subjected to 45 min of hepatic ischemia followed by 60 min of reperfusion period. LYC at the doses of 2.5 and 5 mg/kg body weight (bw) were injected intraperitoneally, 60 min prior to ischemia. Upon sacrification, hepatic tissue samples were used for the measurement of catalase (CAT) activity and malondialdehyde (MDA) levels. Also, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were assayed in serum samples. As a result of the use of LYC at the doses of 2.5 and 5 mg/kg bw; while improvements of the ALT, AST, LDH and MDA values were partial and dose-dependent, the improvement of CAT activity was total and dose-independent (p < 0.05). Our findings suggest that LYC has a protective effect against ischemia/reperfusion injury on the liver.
authors.affiliation: Department of Biology, Faculty of Art and Sciences, Artvin Coruh University, 08000, Artvin, Turkey, gbayramoglu@artvin.edu.tr.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Bayramoglu
authors.forename: Aysegul
authors.initials: A
authors.lastname: Bayramoglu
authors.forename: Yılmaz
authors.initials: Y
authors.lastname: Altuner
authors.forename: Mustafa
authors.initials: M
authors.lastname: Uyanoglu
authors.forename: Suat
authors.initials: S
authors.lastname: Colak