title: Effect of dichloromethane fraction of Areca catechu nut on monoamines associated behaviors and tyramine pressor sensitivity in rodents.
abstract: The current study was aimed at investigating the effect of Areca catechu nut dichloromethane fraction (7 mg/kg) on monoamines (serotonin and dopamine) modulation (5-hydroxytryptophan-induced tremors and phenylethylamine-induced stereotypes) and its interaction with tyramine (cheese effect). The dichloromethane fraction caused pronounced increase in 5-HTP-induced tremors (50%) with negligible PEA-induced stereotypes (20%). Additionally, it did not produce a significant increase in the tyramine pressor effects. These results suggest that the dichloromethane fraction of A. catechu nut primarily elevates serotonin levels (probably via monoamine oxidase A inhibition) and does not induce cheese effect.
authors.affiliation: Department of Biological and Biomedical Sciences, Aga Khan University Hospital, Medical College, Karachi, Pakistan.
authors.forename: Shagufta
authors.initials: S
authors.lastname: Khan
authors.affiliation: Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
authors.forename: Ghulam
authors.initials: G
authors.lastname: Abbas
authors.affiliation: Department of Post Graduate of Medical Education, Aga Khan University Hospital, Medical College, Karachi, Pakistan.
authors.forename: Fahad Shabbir
authors.initials: FS
authors.lastname: Ahmed
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
authors.forename: Attaur
authors.initials: A
authors.lastname: Rahman
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakistan.
authors.forename: Ahsana
authors.initials: A
authors.lastname: Dar
mesh_terms: D006916:5-Hydroxytryptophan; D000818:Animals; D001114:Areca / Q000737:chemistry*; D001522:Behavior, Animal / Q000187:drug effects*; D015306:Biogenic Monoamines / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D008752:Methylene Chloride; D020912:Moclobemide / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010624:Phenelzine / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism; D012997:Solvents; D013239:Stereotyped Behavior / Q000187:drug effects; D014202:Tremor / Q000139:chemically induced / Q000517:prevention & control; D014439:Tyramine / Q000494:pharmacology*
chemical_list: D015306:Biogenic Monoamines; D008996:Monoamine Oxidase Inhibitors; D010936:Plant Extracts; D012997:Solvents; D012701:Serotonin; D008752:Methylene Chloride; D006916:5-Hydroxytryptophan; D010624:Phenelzine; D020912:Moclobemide; D004298:Dopamine; D014439:Tyramine