title: Wavefront sensorless adaptive optics optical coherence tomography for in vivo retinal imaging in mice.
abstract: We present wavefront sensorless adaptive optics (WSAO) Fourier domain optical coherence tomography (FD-OCT) for in vivo small animal retinal imaging. WSAO is attractive especially for mouse retinal imaging because it simplifies optical design and eliminates the need for wavefront sensing, which is difficult in the small animal eye. GPU accelerated processing of the OCT data permitted real-time extraction of image quality metrics (intensity) for arbitrarily selected retinal layers to be optimized. Modal control of a commercially available segmented deformable mirror (IrisAO Inc.) provided rapid convergence using a sequential search algorithm. Image quality improvements with WSAO OCT are presented for both pigmented and albino mouse retinal data, acquired in vivo.
authors.affiliation: Engineering Science, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Jian
authors.affiliation: Engineering Science, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.affiliation: Engineering Science, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
authors.forename: Martin A
authors.initials: MA
authors.lastname: Gradowski
authors.affiliation: CNR-Institute of Photonics and Nanotechnology, via Trasea 7, 35131, Padova, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Bonora
authors.affiliation: Vision Science and Advanced Retinal Imaging Laboratory (VSRI),Department of Ophthalmology & Vision Science, University of California Davis, 4860 Y Street, Ste. 2400, Sacramento, CA 95817, USA ; UC Davis Eye-Pod, Dept. of Cell Biology and Human Anatomy, University of California Davis,4320 Tupper Hall, Davis, CA, 95616, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Zawadzki
authors.affiliation: Engineering Science, Simon Fraser University, Burnaby, BC, V5A 1S6, Canada.
authors.forename: Marinko V
authors.initials: MV
authors.lastname: Sarunic
keywords: (110.1080) Active or adaptive optics; (110.4500) Optical coherence tomography; (170.4460) Ophthalmic optics and devices