title: Role of the hemostatic system on sickle cell disease pathophysiology and potential therapeutics.
abstract: Recent studies suggest that sickle cell disease (SCD) is a hypercoagulable state contributing to vaso-occlusive events in the microcirculation, resulting in acute and chronic sickle cell-related organ damage. In this article, we review the existing evidence for contribution of hemostatic system perturbation to SCD pathophysiology. We also review the data showing increased risk of thromboembolic events, particularly newer information on the incidence of venous thromboembolism. Finally, the potential role of platelet inhibitors and anticoagulants in SCD is briefly reviewed.
authors.affiliation: Division of Hematology Oncology, Davis School of Medicine, 4501 X Street, Suite 3016, Sacramento, CA 95817, USA.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Pakbaz
authors.affiliation: Division of Hematology Oncology, Davis School of Medicine, 4501 X Street, Suite 3016, Sacramento, CA 95817, USA; UC Davis Clinical and Translational Sciences Center, VA Northern California Health Care System, Sacramento, CA, USA. Electronic address: ted.wun@ucdmc.ucdavis.edu.
authors.forename: Ted
authors.initials: T
authors.lastname: Wun
mesh_terms: D000074:Acenocoumarol / Q000627:therapeutic use; D000755:Anemia, Sickle Cell / Q000188:drug therapy* / Q000503:physiopathology; D000925:Anticoagulants / Q000627:therapeutic use; D006487:Hemostasis / Q000187:drug effects* / Q000502:physiology; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D013923:Thromboembolism / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006490:Hemostatics; D000074:Acenocoumarol
keywords: Anti-platelets; Anticoagulants; Hypercoagulable; Sickle cell; Thromboembolism