title: Pentraxin 3 and C-reactive protein as inflammatory markers after a kidney transplant.
abstract: OBJECTIVE
  There are numerous changes in inflammatory status that occur after a kidney transplant. Pentraxin 3 is a marker of inflammation, but little information is available about pentraxin 3 levels after a kidney transplant. We evaluated the relation between pentraxin 3 and other inflammatory markers including high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor alpha in kidney transplant recipients.
  
  
  METHODS
  Adult patients (40 patients; aged, 18-80 y; mean age, 38 ± 10 y) who had a kidney transplant from living-related donors were studied. Patients who had comorbidities associated with chronic inflammation were excluded. Blood samples were obtained before starting immunosuppressive treatment and 2 months after kidney transplant for measurement of pentraxin 3, high sensitivity C-reactive protein, interleukin 6, and tumor necrosis factor α levels.
  
  
  RESULTS
  After transplant, mean levels of high sensitivity C-reactive protein and interleukin 6 decreased but levels of pentraxin 3 and tumor necrosis factor alpha did not change. There were significant correlations between interleukin 6 and high sensitivity C-reactive protein before transplant (r = 0.71; P ≤ .0001) and after transplant (r = 0.45; P ≤ .003). There was no correlation between tumor necrosis factor alpha and high sensitivity C-reactive protein before transplant, but there was a significant correlation between tumor necrosis factor alpha and high sensitivity C-reactive protein after transplant (r = 0.36; P ≤ .03). There was no correlation between interleukin 6 and pentraxin 3, tumor necrosis factor alpha and pentraxin 3, or high sensitivity C-reactive protein and pentraxin 3 before or after transplant.
  
  
  CONCLUSIONS
  After a kidney transplant, pentraxin 3 may not be useful in determining inflammatory status, and high sensitivity C-reactive protein may be better than pentraxin 3 as a marker of inflammation.
authors.affiliation: From the Department of Nephrology, Haseki Training and Research Hospital, Istanbul, Turkey.
authors.forename: Meltem
authors.initials: M
authors.lastname: Gursu
authors.forename: Kenan
authors.initials: K
authors.lastname: Celik
authors.forename: Savas
authors.initials: S
authors.lastname: Ozturk
authors.forename: Aydin
authors.initials: A
authors.lastname: Turkmen
authors.forename: Serpil
authors.initials: S
authors.lastname: Gorcin
authors.forename: Burak
authors.initials: B
authors.lastname: Kocak
authors.forename: Soner
authors.initials: S
authors.lastname: Sari
authors.forename: Macit
authors.initials: M
authors.lastname: Koldas
authors.forename: Hikmet
authors.initials: H
authors.lastname: Feyizoglu
authors.forename: Rumeyza
authors.initials: R
authors.lastname: Kazancioglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D013997:Time Factors; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D018836:Inflammation Mediators; D015850:Interleukin-6; D000683:Serum Amyloid P-Component; D014409:Tumor Necrosis Factor-alpha; D000099153:Pentraxins; C508600:IL6 protein, human