title: Is midazolam superior to triclofos and hydroxyzine as premedicant in children?
abstract: BACKGROUND
  Search for an ideal premedicant drug for children is still on. A prospective, randomized trial was conducted to compare the efficacy of midazolam, triclofos and hydroxyzine as premedication in children undergoing lower abdominal surgeries.
  
  
  METHODS
  Sixty American Society of Anesthesiologists I or II patients 2-8 years of age, scheduled for elective lower abdominal surgery were included. The patients were randomly divided into three groups M, T and H of 20 children each who received midazolam 0.5 mg/kg, triclofos 75 mg/kg and hydroxyzine 0.5 mg/kg respectively, orally 60 min before surgery. The acceptability of drugs, level of sedation, anxiety during separation and on mask application was assessed.
  
  
  RESULTS
  The acceptability of midazolam and hydroxyzine was better than triclofos. Hydroxyzine was found to have lesser sedative effect as compared to both midazolam and triclofos. No major adverse effects were observed.
  
  
  CONCLUSIONS
  Midazolam was found to be a better premedicant in terms of sedation, anxiolysis and safety.
authors.affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Sujata
authors.initials: S
authors.lastname: Chaudhary
authors.affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Reena
authors.initials: R
authors.lastname: Jindal
authors.affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Gautam
authors.initials: G
authors.lastname: Girotra
authors.affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Salhotra
authors.affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Rajesh Singh
authors.initials: RS
authors.lastname: Rautela
authors.affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.
authors.forename: Ashok Kumar
authors.initials: AK
authors.lastname: Sethi
keywords: Children; hydroxyzine; midazolam; premedication; triclofos