title: Aspidosperma species as sources of antimalarials. Part III. A review of traditional use and antimalarial activity.
abstract: Several plant species belonging to the genus Aspidosperma are traditionally used in Brazil and other Meso- and South American countries for the treatment of malaria and fevers. These traditional uses were motivation for this review. A literature survey completed for this review has identified scientific bibliographical references to the use of 24 Aspidosperma species to treat malaria/fevers and to 19 species that have had their extracts and/or alkaloids evaluated, with good results, for in vitro and/or in vivo antimalarial activity. Indole alkaloids are typical constituents of Aspidosperma species. However, only 20 out of more than 200 known indole alkaloids isolated from this genus have been assayed for antimalarial activity. These data support the potential of Aspidosperma species as sources of antimalarials and the importance of research aimed at validating their use in the treatment of human malaria.
authors.affiliation: Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Renata Cristina
authors.initials: RC
authors.lastname: de Paula
authors.affiliation: Departamento de Farmácia, ICS, Universidade Federal do Pará, Belém, PA, Brazil.
authors.forename: Maria Fâni
authors.initials: MF
authors.lastname: Dolabela
authors.affiliation: Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
authors.forename: Alaíde Braga
authors.initials: AB
authors.lastname: de Oliveira
mesh_terms: D000962:Antimalarials / Q000494:pharmacology*; D030009:Aspidosperma / Q000737:chemistry*; D006801:Humans; D008519:Medicine, Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D013020:South America
chemical_list: D000962:Antimalarials; D010936:Plant Extracts