title: TNF-α inhibition elicited by mansoins A and B, heterotrimeric flavonoids isolated from Mansoa hirsuta.
abstract: Mansoins A (1) and B (2) isolated from the fruits of Mansoa hirsuta represent new glucosylated heterotrimeric flavonoids with a flavanone core linked to two 1,3-diarylpropane C6-C3-C6 units. Their structures and absolute configurations were established by analysis of their NMR and electronic circular dichroism spectroscopic data. Compounds 1 and 2 inhibited TNF-α release by LPS-stimulated THP-1 cells with different potencies, with mansoin B (2) being active at lower concentrations than mansoin A (1) (IC50 values 20.0±1.4 and 48.1±1.8 μM, respectively). These results indicate potential anti-inflammatory properties for this structural type of oligoflavonoids, especially for mansoin B (2).
authors.affiliation: Faculty of Pharmacy, Universidade Federal de Minas Gerais , Belo Horizonte, MG, 31270-901, Brazil.
authors.forename: Priscilla R V
authors.initials: PR
authors.lastname: Campana
authors.forename: Christina M
authors.initials: CM
authors.lastname: Coleman
authors.forename: Mauro M
authors.initials: MM
authors.lastname: Teixeira
authors.forename: Daneel
authors.initials: D
authors.lastname: Ferreira
authors.forename: Fernão C
authors.initials: FC
authors.lastname: Braga
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D029402:Bignoniaceae / Q000737:chemistry*; D001938:Brazil; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D015394:Molecular Structure; D009569:Nitric Oxide; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D008070:Lipopolysaccharides; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C000589756:mansoin A; C000589757:mansoin B; D009569:Nitric Oxide