title: Meta-analysis of immunohistochemical expression of hypoxia inducible factor-1α as a prognostic role in gastric cancer.
abstract: OBJECTIVE
  To conduct a meta-analysis to evaluate the prognostic role of hypoxia inducible factor-1α (HIF-1α) expression in gastric cancer.
  
  
  METHODS
  The PubMed, EMBASE, and Web of Science databases were searched systematically for all articles published in English before August, 2013. Pooled effect was calculated from the available data to evaluate the association between HIF-1α expression and 5-year overall survival and tumor clinicopathological features in gastric cancer patients. Pooled odds ratios (ORs) with 95%CIs were calculated using either a fixed-effects or a random-effects model.
  
  
  RESULTS
  Nine studies matched the selection criteria, which reported on 1103 subjects, 548 of whom had HIF-1α positive expression (50%). This meta-analysis indicated that HIF-1α positive expression in gastric cancer correlated with lower 5-year overall survival (OR = 0.36; 95%CI: 0.21-0.64), worse tumor differentiation (OR = 0.38; 95%CI: 0.23-0.64), deeper invasion (OR = 0.42; 95%CI: 0.32-0.57), higher rates of lymph node metastasis (OR = 2.23; 95%CI: 1.46-3.40), lymphatic invasion (OR = 2.50; 95%CI: 1.46-4.28), and vascular invasion (OR = 1.80; 95%CI: 1.29-2.51), and higher TNM stage (III + IV) (OR = 0.31; 95%CI: 0.15-0.60).
  
  
  CONCLUSIONS
  HIF-1α positive expression indicates a poor prognosis for patients with gastric cancer. Further studies are required to confirm these results.
authors.affiliation: Shuang Lin, Xue-Yong Zheng, Hong Yu, Xiao Liang, Hui Lin, Xiu-Jun Cai, Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Institute of Minimally Invasive Surgery, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Lin
authors.affiliation: Shuang Lin, Xue-Yong Zheng, Hong Yu, Xiao Liang, Hui Lin, Xiu-Jun Cai, Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Institute of Minimally Invasive Surgery, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Ma
authors.affiliation: Shuang Lin, Xue-Yong Zheng, Hong Yu, Xiao Liang, Hui Lin, Xiu-Jun Cai, Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Institute of Minimally Invasive Surgery, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
authors.forename: Xue-Yong
authors.initials: XY
authors.lastname: Zheng
authors.affiliation: Shuang Lin, Xue-Yong Zheng, Hong Yu, Xiao Liang, Hui Lin, Xiu-Jun Cai, Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Institute of Minimally Invasive Surgery, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Yu
authors.affiliation: Shuang Lin, Xue-Yong Zheng, Hong Yu, Xiao Liang, Hui Lin, Xiu-Jun Cai, Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Institute of Minimally Invasive Surgery, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Liang
authors.affiliation: Shuang Lin, Xue-Yong Zheng, Hong Yu, Xiao Liang, Hui Lin, Xiu-Jun Cai, Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Institute of Minimally Invasive Surgery, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Lin
authors.affiliation: Shuang Lin, Xue-Yong Zheng, Hong Yu, Xiao Liang, Hui Lin, Xiu-Jun Cai, Department of General Surgery, Sir Run Run Shaw Hospital, College of Medicine, Institute of Minimally Invasive Surgery, Zhejiang University, Hangzhou 310016, Zhejiang Province, China.
authors.forename: Xiu-Jun
authors.initials: XJ
authors.lastname: Cai
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D016009:Chi-Square Distribution; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000032:analysis*; D007150:Immunohistochemistry; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016019:Survival Analysis
chemical_list: D014408:Biomarkers, Tumor; C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit
keywords: 5-year overall survival; Clinicopathological features; Gastric cancer; Hypoxia inducible factor-1α; Meta-analysis