title: Physiological changes induced by salt intake in female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rat, a novel obese type 2 diabetic model.
abstract: Salt plays an important role in the control of blood pressure in obesity and diabetes mellitus. In this study, we investigated physiological changes such as blood pressure and renal function in salt-loaded female Spontaneously Diabetic Torii-Lepr(fa) (SDT fatty) rats. SDT fatty rats were given 1% NaCl in drinking water for 14 weeks, from 4 to 18 weeks of age. Significant salt-sensitive hypertension was observed in the salt-loaded SDT fatty rats. Moreover, the salt-loaded rats showed a decrease of creatinine clearance and deterioration on pathological renal findings, including glomerulosclerosis and tubular and interstitial lesions. Female SDT fatty rat is a useful model for investigating the mechanisms of high salt sensitivity in obesity and diabetes mellitus.
authors.affiliation: Japan Tobacco Inc., Central Pharmaceutical Research Institute, Takatsuki, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Katsuda
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kemmochi
authors.forename: Mimi
authors.initials: M
authors.lastname: Maki
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Sano
authors.forename: Yukihito
authors.initials: Y
authors.lastname: Ishii
authors.forename: Katsuhiro
authors.initials: K
authors.lastname: Miyajima
authors.forename: Kochi
authors.initials: K
authors.lastname: Kakimoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D003404:Creatinine / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D007668:Kidney / Q000473:pathology / Q000503:physiopathology; D009765:Obesity / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000494:pharmacology*
chemical_list: D012965:Sodium Chloride; D003404:Creatinine
keywords: SDT fatty rat; blood pressure; salt