title: OCT-1 overexpression is associated with poor prognosis in patients with well-differentiated gastric cancer.
abstract: Octamer transcription factor-1 (OCT-1) is a well-known transcription factor that is reportedly overexpressed in intestinal metaplasia and gastric carcinoma in the intestine. In this study, we investigated OCT-1 overexpression as a prognostic factor for gastric cancer. The association between OCT-1 overexpression (detected using immunohistochemistry) and clinicopathological features including survival was evaluated. In vitro gain-of-function approaches were utilized to assess the function of OCT-1 in malignancy. Analysis of OCT-1 expression in patients with gastric cancer with well-differentiated carcinoma as per the World Health Organization classification showed that OCT-1 overexpression was correlated with advanced tumor invasion (58.8 % of patients with advanced tumor invasion vs. 21.2 % of patients with early tumor invasion; p<0.01), lymph node metastasis (63.9 % of patients with metastasis vs. 24.1 % of those without; p=0.015), and cancer recurrence (83.3 % of patients with recurrence vs. 25.4 % of those without; p<0.01), as well as a lower survival rate (62.8 vs. 87.9 Mo; p<0.01). However, there were no significant differences in the levels of OCT-1 expression in gastric cancer patients with other carcinoma types (p>0.05). Furthermore, we found that the proliferation rate of OCT-1-overexpressing MKN-45 cells was higher than that of the control cells. OCT-1 overexpression may be a marker for poor prognosis in patients with well-differentiated gastric adenocarcinoma.
authors.affiliation: Department of Surgery/Gyeongnam Regional Cancer Center, College of Natural Sciences, Gyeongsang National University, 79 Gangnam-ro, Jinju, Gyeongsang South Province, 660-702, South Korea.
authors.forename: Sang-Ho
authors.initials: SH
authors.lastname: Jeong
authors.forename: Young-Joon
authors.initials: YJ
authors.lastname: Lee
authors.forename: Bok-Im
authors.initials: BI
authors.lastname: Cho
authors.forename: Woo-Song
authors.initials: WS
authors.lastname: Ha
authors.forename: Sang-Kyung
authors.initials: SK
authors.lastname: Choi
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Jung
authors.forename: Young-Tae
authors.initials: YT
authors.lastname: Ju
authors.forename: Chi-Young
authors.initials: CY
authors.lastname: Jeong
authors.forename: Gyung Hyuck
authors.initials: GH
authors.lastname: Ko
authors.forename: Jiyun
authors.initials: J
authors.lastname: Yoo
authors.forename: Soon-Chan
authors.initials: SC
authors.lastname: Hong
mesh_terms: D000368:Aged; D000071616:CDX2 Transcription Factor; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D050811:Octamer Transcription Factor-1 / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000737:chemistry / Q000401:mortality* / Q000473:pathology
chemical_list: D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018398:Homeodomain Proteins; D050811:Octamer Transcription Factor-1