title: Gaps in translation from trials to practice: non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation.
abstract: Worldwide there is a tremendous need for affordable anticoagulants that do not require monitoring. The advent of the non-warfarin oral anticoagulant drugs represents a major advance for stroke prevention in atrial fibrillation (AF). The objectives of this review are to 1) identify gaps in our current knowledge regarding use of these single target anticoagulant drugs; 2) outline the potential implications of these gaps for clinical practice, and thereby, 3) highlight areas of research to further optimise their use for stroke prevention in AF.
authors.affiliation: Elaine M. Hylek, MD, MPH, Boston University School of Medicine, Section of General Internal Medicine, 801 Massachusetts Avenue, 2nd fl suite, Boston, MA 02118, USA, Tel.: +1 617 414 3743, E-mail: ehylek@bu.edu.
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Hylek
authors.forename: Darae
authors.initials: D
authors.lastname: Ko
authors.forename: Christina L
authors.initials: CL
authors.lastname: Cove
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D058996:Quality Improvement; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D057170:Translational Research, Biomedical; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D014812:Vitamin K