title: Meta-analysis of the rs4779584 polymorphism and colorectal cancer risk.
abstract: OBJECTIVE
  Several researchers have suggested that the rs4779584 (15q13.3) polymorphism is associated with an increased risk of developing colorectal cancer (CRC). However, past results remain inconclusive. We addressed this controversy by performing a meta-analysis of the relationship between rs4779584 of GREM1-SCG5 and colorectal cancer.
  
  
  METHODS
  We selected 12 case-control studies involving 11,769 cases of CRC and 14,328 healthy controls. The association between the rs4779584 polymorphism and CRC was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used different genetic model analyses, sensitivity analyses, and assessments of bias in our meta-analysis.
  
  
  RESULTS
  GREM1-SCG5 rs4779584 polymorphisms were associated with CRC in all of the genetic models that were examined in this meta-analysis of 12 case-control studies.
  
  
  CONCLUSIONS
  GREM1-SCG5 rs4779584 polymorphisms may increase the risk of developing colorectal cancer.
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.affiliation: School of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Ya
authors.initials: Y
authors.lastname: Gao
authors.affiliation: National Engineering Research Center for Miniaturized Detection Systems, Xi'an, Shaanxi, China.
authors.forename: Tian
authors.initials: T
authors.lastname: Feng
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China ; National Engineering Research Center for Miniaturized Detection Systems, Xi'an, Shaanxi, China ; Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Tibet University for Nationalities, Xianyang, Shaanxi, China.
authors.forename: Tian-Bo
authors.initials: TB
authors.lastname: Jin
authors.affiliation: Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Tibet University for Nationalities, Xianyang, Shaanxi, China.
authors.forename: Long-Li
authors.initials: LL
authors.lastname: Kang
authors.affiliation: School of Life Sciences, Northwest University, Xi'an, Shaanxi, China ; National Engineering Research Center for Miniaturized Detection Systems, Xi'an, Shaanxi, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008957:Models, Genetic; D051859:Neuroendocrine Secretory Protein 7B2 / Q000235:genetics; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis
chemical_list: C486399:GREM1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; D051859:Neuroendocrine Secretory Protein 7B2; C497678:SCG5 protein, human