title: Ultra-short term clomiphene citrate in high responder women with polycystic ovary syndrome: a case series.
abstract: OBJECTIVE
  To evaluate a new trial of short-term clomiphene citrate (CC) in high responder women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  This case series was conducted in the infertility outpatient clinics of two centres. Ovulation induction was performed with CC 50-100mg a day in six high-responder women with PCOS who had a history of cancellation of treatment because of ≥3 mature follicles between March 2010 and June 2013. Induction was initiated on the third day of their cycles and the duration of induction was only two days. Demographic data of the patients, number of mature follicles on hCG day, ovulation rate, luteal phase length, pregnancy rate, and type of pregnancy were recorded. All data were analysed by SPSS packet programme (SPSS, 17.0, SPSS Inc., Chicago, IL, USA).
  
  
  RESULTS
  The median number of mature follicles and duration of the follicular phase were 1.3 (1-2) and 11.9 (11-14) days, respectively. The ovulation rate was 80% (12/15) and pregnancy rate per cycle was 26.6%.
  
  
  CONCLUSIONS
  If this hypothesis is supported by large prospective randomised controlled studies, ultra-short term ovulation induction with CC may provide an alternative approach for high-responder women with PCOS who have a history of treatment cycle cancellations.
authors.affiliation: Eagen Maternity and Gynaecology Education and Research Hospital, Izmir, Turkey; Izmir Katip Celebi University, School of Medicine, Department of Obstetrics and Gynaecology, Izmir, Turkey. Electronic address: sefakelekci@gmail.com.
authors.forename: Sefa
authors.initials: S
authors.lastname: Kelekci
authors.affiliation: Izmir Katip Celebi University, School of Medicine, Department of Obstetrics and Gynaecology, Izmir, Turkey. Electronic address: serenateris@Hotmail.Com.
authors.forename: Serenat
authors.initials: S
authors.lastname: Eris
authors.affiliation: Izmir Katip Celebi University, School of Medicine, Department of Obstetrics and Gynaecology, Izmir, Turkey. Electronic address: er_Em.Dr@Hotmail.Com.
authors.forename: Emine
authors.initials: E
authors.lastname: Demirel
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage*; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene
keywords: Clomiphene citrate; Ovulation induction; Ovulation rate; PCOS; Pregnancy rate