title: Pediatric low-grade gliomas: how modern biology reshapes the clinical field.
abstract: Low-grade gliomas represent the most frequent brain tumors arising during childhood. They are characterized by a broad and heterogeneous group of tumors that are currently classified by the WHO according to their morphological appearance. Here we review the clinical features of these tumors, current therapeutic strategies and the recent discovery of genomic alterations characteristic to these tumors. We further explore how these recent biological findings stand to transform the treatment for these tumors and impact the diagnostic criteria for pediatric low-grade gliomas.
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bergthold
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Division of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Boston Children's Hospital, Boston, MA, USA.
authors.forename: Pratiti
authors.initials: P
authors.lastname: Bandopadhayay
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Wenya Linda
authors.initials: WL
authors.lastname: Bi
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Lori
authors.initials: L
authors.lastname: Ramkissoon
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Stiles
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
authors.forename: Rosalind A
authors.initials: RA
authors.lastname: Segal
authors.affiliation: Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Rameen
authors.initials: R
authors.lastname: Beroukhim
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
authors.forename: Keith L
authors.initials: KL
authors.lastname: Ligon
authors.affiliation: Departement de Cancerologie de l'enfant et de l'adolescent, Gustave Roussy and Unité Mixte de Recherche 8203 du Centre National de la Recherche Scientifique, Université Paris-Sud, Villejuif, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Grill
authors.affiliation: Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA; Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: mark_kieran@dfci.harvard.edu.
authors.forename: Mark W
authors.initials: MW
authors.lastname: Kieran
mesh_terms: D017209:Apoptosis / Q000235:genetics; D001932:Brain Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D002470:Cell Survival / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics; D005910:Glioma / Q000453:epidemiology / Q000235:genetics / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D058990:Molecular Targeted Therapy; D060787:Neoplasm Grading; D010372:Pediatrics; D011379:Prognosis
keywords: BRAF; Genetics; Low-grade glioma; Pediatric