title: [GM6001 suppresses scar formation after glaucoma filtration surgery in rabbits].
abstract: OBJECTIVE
  To study the effect of matrix metalloproteinases inhibitor GM6001 in suppressing scar tissue formation in the filtering passage after glaucoma filtration surgery.
  
  
  METHODS
  Twenty-four pigmented rabbits (48 eyes) underwent trabeculectomy followed by subconjunctival injection of GM6001 in the right eye (treated eyes) and injection of PBS in the left eye (control) once a day. The intraocular pressure was monitored postoperatively and proliferating cell nuclear antigen (PCNA)- and α-smooth muscle actin (α-SMA)-positive cells in the filtering pathway were detected using immunohistochemistry.
  
  
  RESULTS
  On postoperative days 7, 14, 21, and 28, the intraocular pressure was significantly lower in the treated eyes (GM6001) than in the control eyes (P<0.01). The counts of PCNA- and α-SMA-positive cells were also significantly lowered in the treated than in the control eyes (P<0.01).
  
  
  CONCLUSIONS
  GM6001 can inhibit excessive proliferation of the fibroblasts in the filtering pathway to suppress scar tissue formation and prolong the existence of the functional filtration bleb in rabbits.
authors.affiliation: Department of Ophthalmology, Zhujiang Hospital, Southem Medical University, Guangzhou 510282, China.E-mail: shenying_abc@sohu.com.
authors.forename: Ying
authors.initials: Y
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Lu
authors.forename: Wenqi
authors.initials: W
authors.lastname: Guo
mesh_terms: D000199:Actins / Q000378:metabolism; D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control*; D004151:Dipeptides / Q000494:pharmacology*; D018463:Filtering Surgery / Q000009:adverse effects*; D005901:Glaucoma / Q000601:surgery; D007429:Intraocular Pressure; D011183:Postoperative Complications; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011817:Rabbits
chemical_list: D000199:Actins; D004151:Dipeptides; C078131:N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide; D018809:Proliferating Cell Nuclear Antigen