title: Antibacterial activity of pepducins, allosterical modulators of formyl peptide receptor signaling.
abstract: Pepducins containing a fatty acid linked to an amino acid sequence derived from cytosolic parts of a G-protein-coupled receptor (GPCR) constitute a new group of lipopeptide tools in GPCR studies. Pepducins corresponding to the third intracellular loop of formyl peptide receptor 2 (FPR2) activate human neutrophils, and we show here that, in addition, these allosteric modulators of receptor activity also kill bacteria. The functional dualism of FPR2 pepducins could potentially be explored as a novel class of antibacterial drugs with immunomodulatory properties.
authors.affiliation: Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Malene
authors.initials: M
authors.lastname: Winther
authors.forename: Michael
authors.initials: M
authors.lastname: Gabl
authors.forename: Tudor I
authors.initials: TI
authors.lastname: Oprea
authors.forename: Bodil
authors.initials: B
authors.lastname: Jönsson
authors.forename: Francois
authors.initials: F
authors.lastname: Boulay
authors.forename: Johan
authors.initials: J
authors.lastname: Bylund
authors.forename: Claes
authors.initials: C
authors.lastname: Dahlgren
authors.forename: Huamei
authors.initials: H
authors.lastname: Forsman
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000378:metabolism; D044042:Receptors, Formyl Peptide / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D044042:Receptors, Formyl Peptide; D043562:Receptors, G-Protein-Coupled