title: A peptide-based nanofibrous hydrogel as a promising DNA nanovector for optimizing the efficacy of HIV vaccine.
abstract: This report shows that a nanovector composed of peptide-based nanofibrous hydrogel can condense DNA to result in strong immune responses against HIV. This nanovector can strongly activate both humoral and cellular immune responses to a balanced level rarely reported in previous studies, which is crucial for HIV prevention and therapy. In addition, this nanovector shows good biosafety in vitro and in vivo. Detailed characterizations show that the nanofibrous structure of the hydrogel is critical for the dramatically improved immune responses compared to existing materials. This peptide-based nanofibrous hydrogel shows great potential for efficacious HIV DNA vaccines and can be potentially used for delivering other vaccines and drugs.
authors.affiliation: Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology , No., 11 Zhongguancun Beiyitiao, Beijing 100190, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Tian
authors.forename: Huaimin
authors.initials: H
authors.lastname: Wang
authors.forename: Ye
authors.initials: Y
authors.lastname: Liu
authors.forename: Lina
authors.initials: L
authors.lastname: Mao
authors.forename: Wenwen
authors.initials: W
authors.lastname: Chen
authors.forename: Zhening
authors.initials: Z
authors.lastname: Zhu
authors.forename: Wenwen
authors.initials: W
authors.lastname: Liu
authors.forename: Wenfu
authors.initials: W
authors.lastname: Zheng
authors.forename: Yuyun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Deling
authors.initials: D
authors.lastname: Kong
authors.forename: Zhimou
authors.initials: Z
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao
authors.forename: Xingyu
authors.initials: X
authors.lastname: Jiang
mesh_terms: D016915:AIDS Vaccines / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology; D000818:Animals; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D020100:Hydrogels / Q000737:chemistry / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects; D056724:Immunity, Humoral / Q000187:drug effects; D051379:Mice; D057139:Nanofibers / Q000737:chemistry*; D019444:Vaccines, DNA / Q000737:chemistry / Q000276:immunology / Q000493:pharmacokinetics
chemical_list: D016915:AIDS Vaccines; D020100:Hydrogels; D019444:Vaccines, DNA