title: Protein profiling of Helicobacter pylori-associated gastric cancer.
abstract: Helicobacter pylori infection is an initiating factor in the development of gastric cancer. Gastric cancer can be divided into two groups on the basis of H. pylori serological status; seropositive H. pylori status predicts favorable prognosis in patients with gastric cancer. By using the protein pathway array, we identified 20 differentially expressed proteins in primary gastric cancer tissues between the H. pylori-seropositive and H. pylori-seronegative groups. Our results indicate that both brassinosteroid insensitive 1-associated kinase 1 and calpastatin are favorable prognostic factors in H. pylori-seropositive gastric cancer patients. In contrast, dachshund homolog 1 is a favorable prognostic factor in H. pylori-seronegative gastric cancer patients. Different signaling pathways were found to be altered between H. pylori-seropositive and H. pylori-seronegative gastric cancer, which may account for the different tumorigenesis and outcomes between these two subsets of patients.
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Guodong
authors.initials: G
authors.lastname: Lian
authors.affiliation: Department of Medicine Bioinformatics Core, Mount Sinai School of Medicine, New York, New York.
authors.forename: Chengguo
authors.initials: C
authors.lastname: Wei
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Daguang
authors.initials: D
authors.lastname: Wang
authors.affiliation: Department of Pathology, Mount Sinai School of Medicine, New York, New York.
authors.forename: Miao
authors.initials: M
authors.lastname: Cui
authors.affiliation: Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Zhiqing
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, First Hospital of Jilin University, Changchun, China.
authors.forename: Xiufen
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China.
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Pathology, Mount Sinai School of Medicine, New York, New York.
authors.forename: David Y
authors.initials: DY
authors.lastname: Zhang
authors.affiliation: Department of Gastrointestinal Surgery, First Hospital of Jilin University, Changchun, China. Electronic address: suojian42@gmail.com.
authors.forename: Jian
authors.initials: J
authors.lastname: Suo
authors.affiliation: Department of Pathology, Mount Sinai School of Medicine, New York, New York. Electronic address: fei.ye@mssm.edu.
authors.forename: Fei
authors.initials: F
authors.lastname: Ye
mesh_terms: D000368:Aged; D016000:Cluster Analysis; D018572:Disease-Free Survival; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000378:metabolism*; D016480:Helicobacter pylori / Q000502:physiology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D040081:Protein Array Analysis; D040901:Proteomics / Q000379:methods*; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000382:microbiology*
chemical_list: D009363:Neoplasm Proteins; D010750:Phosphoproteins