title: Cannabis and stimulant disorders and readmission 2 years after first-episode psychosis.
abstract: BACKGROUND
  Few studies have examined the impact of stimulant use on outcome in early psychosis. Ceasing substance use may lead to positive outcomes in psychosis.
  
  
  OBJECTIVE
  To examine whether baseline cannabis or stimulant disorders and ongoing drug use predict readmission within 2 years of a first psychosis admission.
  
  
  METHODS
  Predictors of readmission were examined with Cox regression in 7269 people aged 15-29 years with a first psychosis admission.
  
  
  RESULTS
  Baseline cannabis and stimulant disorders did not predict readmission. A stimulant disorder diagnosis prior to index psychosis admission predicted readmission, but a prior cannabis disorder diagnosis did not. Ongoing problem drug use predicted readmission. The lowest rate of readmission occurred in people whose baseline drug problems were discontinued.
  
  
  CONCLUSIONS
  Prior admissions with stimulant disorder may be a negative prognostic sign in first-episode psychosis. Drug use diagnoses at baseline may be a good prognostic sign if they are identified and controlled.
authors.affiliation: Grant E. Sara, MB BS, MM, MM (Psychotherapy), FRANZCP, InforMH, Mental Health and Drug and Alcohol Office, NSW Health, Discipline of Psychiatry, Sydney Medical School, University of Sydney, and School of Population Health, University of Queensland, Brisbane, Queensland; Philip M. Burgess, MA, PhD, School of Population Health, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Gin S. Malhi, MBChB, BSc, MD, FRCPsych, FRANZCP, Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, and CADE Clinic, Department of Academic Psychiatry, Royal North Shore Hospital, Sydney, New South Wales; Harvey A. Whiteford, MB BS, MPH, MD, FRANZCP, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Wayne C. Hall, MSc, PhD, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Grant E
authors.initials: GE
authors.lastname: Sara
authors.affiliation: Grant E. Sara, MB BS, MM, MM (Psychotherapy), FRANZCP, InforMH, Mental Health and Drug and Alcohol Office, NSW Health, Discipline of Psychiatry, Sydney Medical School, University of Sydney, and School of Population Health, University of Queensland, Brisbane, Queensland; Philip M. Burgess, MA, PhD, School of Population Health, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Gin S. Malhi, MBChB, BSc, MD, FRCPsych, FRANZCP, Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, and CADE Clinic, Department of Academic Psychiatry, Royal North Shore Hospital, Sydney, New South Wales; Harvey A. Whiteford, MB BS, MPH, MD, FRANZCP, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Wayne C. Hall, MSc, PhD, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Philip M
authors.initials: PM
authors.lastname: Burgess
authors.affiliation: Grant E. Sara, MB BS, MM, MM (Psychotherapy), FRANZCP, InforMH, Mental Health and Drug and Alcohol Office, NSW Health, Discipline of Psychiatry, Sydney Medical School, University of Sydney, and School of Population Health, University of Queensland, Brisbane, Queensland; Philip M. Burgess, MA, PhD, School of Population Health, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Gin S. Malhi, MBChB, BSc, MD, FRCPsych, FRANZCP, Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, and CADE Clinic, Department of Academic Psychiatry, Royal North Shore Hospital, Sydney, New South Wales; Harvey A. Whiteford, MB BS, MPH, MD, FRANZCP, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Wayne C. Hall, MSc, PhD, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Gin S
authors.initials: GS
authors.lastname: Malhi
authors.affiliation: Grant E. Sara, MB BS, MM, MM (Psychotherapy), FRANZCP, InforMH, Mental Health and Drug and Alcohol Office, NSW Health, Discipline of Psychiatry, Sydney Medical School, University of Sydney, and School of Population Health, University of Queensland, Brisbane, Queensland; Philip M. Burgess, MA, PhD, School of Population Health, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Gin S. Malhi, MBChB, BSc, MD, FRCPsych, FRANZCP, Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, and CADE Clinic, Department of Academic Psychiatry, Royal North Shore Hospital, Sydney, New South Wales; Harvey A. Whiteford, MB BS, MPH, MD, FRANZCP, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Wayne C. Hall, MSc, PhD, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Harvey A
authors.initials: HA
authors.lastname: Whiteford
authors.affiliation: Grant E. Sara, MB BS, MM, MM (Psychotherapy), FRANZCP, InforMH, Mental Health and Drug and Alcohol Office, NSW Health, Discipline of Psychiatry, Sydney Medical School, University of Sydney, and School of Population Health, University of Queensland, Brisbane, Queensland; Philip M. Burgess, MA, PhD, School of Population Health, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Gin S. Malhi, MBChB, BSc, MD, FRCPsych, FRANZCP, Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, and CADE Clinic, Department of Academic Psychiatry, Royal North Shore Hospital, Sydney, New South Wales; Harvey A. Whiteford, MB BS, MPH, MD, FRANZCP, Queensland Centre for Mental Health Research, University of Queensland, Brisbane, Queensland; Wayne C. Hall, MSc, PhD, Centre for Clinical Research, University of Queensland, Brisbane, Queensland, Australia.
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Hall
mesh_terms: D000293:Adolescent; D000328:Adult; D019969:Amphetamine-Related Disorders / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000453:epidemiology*; D009517:New South Wales / Q000453:epidemiology; D010359:Patient Readmission / Q000706:statistics & numerical data*; D011618:Psychotic Disorders / Q000453:epidemiology*; D055815:Young Adult