title: Genomes in the clinic: the Gustave Roussy Cancer Center experience.
abstract: The extensive molecular characterization of tumors with high throughput technologies has led to the segmentation of different tumors into very small molecularly defined subgroups. Many ongoing clinical trials are conducted only when specific molecular alterations are identified in tumor samples. In this review, we will describe the implementation of genome analysis in the clinical setting as it has expanded over the last four years in our Precision Medicine Program. This manuscript will also highlight the main limitations and challenges related to the development of broader and deeper genome analysis.
authors.affiliation: Gustave Roussy, Translational Research Laboratory and Biobank, Villejuif F-94805, France; Gustave Roussy, Inserm U981, Villejuif F-94805, France; Gustave Roussy, Department of Medical Biology and Pathology, Villejuif F-94805, France. Electronic address: LACROIX.Ludovic@gustaveroussy.fr.
authors.forename: Ludovic
authors.initials: L
authors.lastname: Lacroix
authors.affiliation: Gustave Roussy, Translational Research Laboratory and Biobank, Villejuif F-94805, France; Gustave Roussy, Department of Medical Biology and Pathology, Villejuif F-94805, France.
authors.forename: Amelie
authors.initials: A
authors.lastname: Boichard
authors.affiliation: Gustave Roussy, Inserm U981, Villejuif F-94805, France; Gustave Roussy, Department of Medical Oncology, Villejuif F-94805, France.
authors.forename: Fabrice
authors.initials: F
authors.lastname: André
authors.affiliation: Gustave Roussy, Inserm U981, Villejuif F-94805, France; Gustave Roussy, Drug Development Department, Villejuif F-94805, France.
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Soria
mesh_terms: D002173:Cancer Care Facilities; D059472:Exome; D015894:Genome, Human; D059014:High-Throughput Nucleotide Sequencing; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D057285:Precision Medicine