title: Hydrogen sulfide and the liver.
abstract: Hydrogen sulfide (H2S) is a gasotransmitter that regulates numerous physiological and pathophysiological processes in our body. Enzymatic production of H2S is catalyzed by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS), and 3-mercaptopyruvate sulfurtransferase (MST). All these three enzymes present in the liver and via H2S production regulate liver functions. The liver is the hub for metabolism of glucose and lipids, and maintains the level of circulatory lipids through lipoprotein metabolism. Hepatic H2S metabolism affects glucose metabolism, insulin sensitivity, lipoprotein synthesis, mitochondrial biogenetics and biogenesis. Malfunction of hepatic H2S metabolism may be involved in many liver diseases, such as hepatic fibrosis and hepatic cirrhosis.
authors.affiliation: Department of Biology, Lakehead University, Thunder Bay, Canada; Cardiovascular and Metabolic Research Unit, Lakehead University, Thunder Bay, Canada.
authors.forename: Sarathi
authors.initials: S
authors.lastname: Mani
authors.affiliation: Cardiovascular and Metabolic Research Unit, Lakehead University, Thunder Bay, Canada; Thunder Bay Regional Research Institute, Thunder Bay, Canada; Department of Natural Medicine & Institute of Materia Medica, Fourth Military Medical University, Xi'an, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cao
authors.affiliation: Cardiovascular and Metabolic Research Unit, Lakehead University, Thunder Bay, Canada; Thunder Bay Regional Research Institute, Thunder Bay, Canada; Department of Health Sciences, Lakehead University, Thunder Bay, Canada.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Biology, Lakehead University, Thunder Bay, Canada; Cardiovascular and Metabolic Research Unit, Lakehead University, Thunder Bay, Canada. Electronic address: rwang@lakeheadu.ca.
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D050356:Lipid Metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D008107:Liver Diseases; D051379:Mice; D051381:Rats
chemical_list: D005947:Glucose; D006862:Hydrogen Sulfide
keywords: Cirrhosis; Diabetes; Hydrogen sulfide; Lipids; Liver; Oxidative stress