title: Psoriasis associated with idiopathic CD4+ T-cell lymphopenia: a regulatory T-cell defect?
abstract: Idiopathic CD4(+) lymphocytopenia (ICL) is a rare immunodeficiency syndrome of unknown origin for which the increased risks of opportunistic infections and of malignancies have been well established; however, skin dysimmune diseases, including psoriasis, have been scarcely reported up to now. We report herein the severe course of psoriasis in four patients with ICL, and show evidence for a defect in the skin recruitment of regulatory CD4(+) FoxP3(+) T cells. These data raise the apparent paradigm of the occurrence of a severe immunomediated disease together with a profound T-cell defect, a model that might also apply to other immune deficiencies associated with psoriasis.
authors.affiliation: Dermatology, Université Paris Diderot, Sorbonne Paris Cité, Assistance Publique-Hôpitaux de Paris (APHP), Hôpital Saint-Louis, 1, Avenue Claude-Vellefaux, 75475, Paris, Cedex 10, France.
authors.forename: B
authors.initials: B
authors.lastname: Baroudjian
authors.forename: M
authors.initials: M
authors.lastname: Viguier
authors.forename: M
authors.initials: M
authors.lastname: Battistella
authors.forename: N
authors.initials: N
authors.lastname: Beneton
authors.forename: C
authors.initials: C
authors.lastname: Pagès
authors.forename: G
authors.initials: G
authors.lastname: Gener
authors.forename: E
authors.initials: E
authors.lastname: Bégon
authors.forename: H
authors.initials: H
authors.lastname: Bachelez
mesh_terms: D000328:Adult; D002908:Chronic Disease; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000209:etiology* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications*