title: The N-myc Oncogene: Maximizing its Targets, Regulation, and Therapeutic Potential.
abstract: N-myc (MYCN), a member of the Myc family of basic-helix-loop-helix-zipper (bHLHZ) transcription factors, is a central regulator of many vital cellular processes. As such, N-myc is well recognized for its classic oncogenic activity and association with human neuroblastoma. Amplification and overexpression of N-myc has been described in other tumor types, particularly those of neural origin and neuroendocrine tumors. This review outlines N-myc's contribution to normal development and oncogenic progression. In addition, it highlights relevant transcriptional targets and mechanisms of regulation. Finally, the clinical implications of N-Myc as a biomarker and potential as a target using novel therapeutic approaches are discussed.
authors.affiliation: Author's Affiliation: Weill Cornell Medical College, New York, New York hip9004@med.cornell.edu.
authors.forename: Himisha
authors.initials: H
authors.lastname: Beltran
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D018390:Gene Targeting; D016259:Genes, myc; D006801:Humans; D058990:Molecular Targeted Therapy; D009447:Neuroblastoma / Q000235:genetics / Q000628:therapy; D018358:Neuroendocrine Tumors / Q000235:genetics / Q000628:therapy; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*
chemical_list: D016271:Proto-Oncogene Proteins c-myc