title: A 12-week weight reduction intervention for overweight individuals taking antipsychotic medications.
abstract: People taking antipsychotic medications are at increased risk for obesity, diabetes, and early mortality. Few weight loss interventions have targeted this population. Thirty-six individuals were randomized to an evidence-based 12-week weight loss intervention (PREMIER with DASH diet, n = 18) or to usual care (n = 18) in this feasibility trial. Average attendance was 8.6 of 12 sessions. Intent-to-treat analyses of covariance, adjusted for baseline weight, showed significant changes in weight: Mean weight in intervention participants declined from 213.3 to 206.6 pounds, while control participants' weight was unchanged. It is possible to recruit, assess, intervene with, and retain participants taking antipsychotic medications in a dietary and exercise lifestyle change trial. Participants reported high levels of satisfaction with the intervention.
authors.affiliation: Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Ave, Portland, OR, 97227-1110, USA, carla.a.green@kpchr.org.
authors.forename: Carla A
authors.initials: CA
authors.lastname: Green
authors.forename: Shannon L
authors.initials: SL
authors.lastname: Janoff
authors.forename: Bobbi Jo H
authors.initials: BJ
authors.lastname: Yarborough
authors.forename: Micah T
authors.initials: MT
authors.lastname: Yarborough
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000009:adverse effects; D015992:Body Mass Index; D004038:Diet, Reducing / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy; D008875:Middle Aged; D050177:Overweight / Q000628:therapy*; D010349:Patient Compliance / Q000706:statistics & numerical data; D017060:Patient Satisfaction; D012649:Self Concept; D016896:Treatment Outcome; D014481:United States; D015431:Weight Loss
chemical_list: D014150:Antipsychotic Agents