title: Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project.
abstract: OBJECTIVE
  To determine the associations between joint metabolism biomarkers and hand radiographic osteoarthritis [(rOA), based on Kellgren Lawrence (KL) grade ≥ 2], symptoms, and function.
  
  
  METHODS
  Cross-sectional data were available for 663 participants (mean age 63 yrs, 63% white, 49% women). Three definitions of hand rOA were considered: (1) a composite measure involving at least 3 hand joints distributed bilaterally with 2 of 3 in the same joint group, including ≥ 1 distal interphalangeal joint, without metacarpophalangeal (MCP) swelling; (2) rOA in at least 1 joint of a group; and (3) number of joints with KL ≥ 2. We assessed hand symptoms and the 15-item Australian Canadian Hand Osteoarthritis Index (AUSCAN; Likert format). We measured serum cartilage oligomeric matrix protein (sCOMP), hyaluronic acid (sHA), carboxy-terminal propeptide of type II collagen, type II collagen degradation product, urinary C-terminal crosslinked telopeptide of type II collagen, and urinary N-terminal crosslinked telopeptide. Linear regression models were performed to assess associations between each biomarker with hand rOA, AUSCAN, and symptoms, adjusting for age, sex, race, current smoking/drinking status, body mass index, and hip and knee rOA.
  
  
  RESULTS
  In adjusted analyses, MCP (p < 0.0001) and carpometacarpal rOA (p = 0.003), and a higher number of hand joints with rOA (p = 0.009), were associated with higher levels of sHA. Positive associations were seen between AUSCAN and hand symptoms and levels of sCOMP (p ≤ 0.003) and sHA (p ≤ 0.048).
  
  
  CONCLUSIONS
  Hand symptoms and higher AUSCAN scores were independently associated with higher levels of both sCOMP and sHA; hand rOA was associated only with sHA levels.
authors.affiliation: From the Northeast Ohio Medical School, Rootstown, Ohio; the School of Medicine, the Thurston Arthritis Research Center, the Department of Radiology, the Department of Epidemiology, and the Department of Orthopedics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill; SAS Institute, Cary; Duke University School of Medicine, Durham, NC, USA.
authors.forename: Imran
authors.initials: I
authors.lastname: Aslam
authors.forename: Irina
authors.initials: I
authors.lastname: Perjar
authors.forename: Xiaoyan A
authors.initials: XA
authors.lastname: Shi
authors.forename: Jordan B
authors.initials: JB
authors.lastname: Renner
authors.forename: Virginia B
authors.initials: VB
authors.lastname: Kraus
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Golightly
authors.forename: Joanne M
authors.initials: JM
authors.lastname: Jordan
authors.forename: Amanda E
authors.initials: AE
authors.lastname: Nelson
mesh_terms: D000328:Adult; D000368:Aged; D018771:Arthralgia / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D052737:Carpometacarpal Joints / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D003430:Cross-Sectional Studies; D005260:Female; D005384:Finger Joint / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D050823:Hand Joints / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008662:Metacarpophalangeal Joint / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D010003:Osteoarthritis / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000503:physiopathology; D011859:Radiography; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers
keywords: BIOMARKERS; HAND JOINTS; OSTEOARTHRITIS; RADIOGRAPHY