title: Learning to segment neurons with non-local quality measures.
abstract: Segmentation schemes such as hierarchical region merging or correllation clustering rely on edge weights between adjacent (super-)voxels. The quality of these edge weights directly affects the quality of the resulting segmentations. Unstructured learning methods seek to minimize the classification error on individual edges. This ignores that a few local mistakes (tiny boundary gaps) can cause catastrophic global segmentation errors. Boundary evidence learning should therefore optimize structured quality criteria such as Rand Error or Variation of Information. We present the first structured learning scheme using a structured loss function; and we introduce a new hierarchical scheme that allows to approximately solve the NP hard prediction problem even for huge volume images. The value of these contributions is demonstrated on two challenging neural circuit reconstruction problems in serial sectioning electron microscopic images with billions of voxels. Our contributions lead to a partitioning quality that improves over the current state of the art.
authors.affiliation: HCI, University of Heidelberg.
authors.forename: Thorben
authors.initials: T
authors.lastname: Kroeger
authors.affiliation: MPI for Medical Research, Heidelberg.
authors.forename: Shawn
authors.initials: S
authors.lastname: Mikula
authors.affiliation: MPI for Medical Research, Heidelberg.
authors.forename: Winfried
authors.initials: W
authors.lastname: Denk
authors.affiliation: HCI, University of Heidelberg.
authors.forename: Ullrich
authors.initials: U
authors.lastname: Koethe
authors.affiliation: HCI, University of Heidelberg.
authors.forename: Fred A
authors.initials: FA
authors.lastname: Hamprecht
mesh_terms: D000465:Algorithms; D000818:Animals; D001185:Artificial Intelligence; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D051379:Mice; D008854:Microscopy, Electron / Q000379:methods*; D009415:Nerve Net / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity