title: High weekly doses of liposomal amphotericin B as secondary prophylaxis after cerebral aspergillosis in a paediatric patient.
abstract: A paediatric patient treated for acute lymphoblastic leukaemia developed cerebral abscesses caused by Aspergillus fumigatus. After surgical draining voriconazole treatment was started. The patient developed a Steven-Johnson syndrome and treatment was switched to L-AmB. The patient developed no new fungal lesions and L-AmB treatment was continued until the end of the therapy. Complete remission was achieved without neurological consequences. High dose L-AmB represents an alternative for secondary prophylaxis of invasive fungal infections in patients intolerant to azoles.
authors.affiliation: Ospedale Regionale di Bellinzona e Valli - Bellinzona, Pediatria, Via Ospedale, CH-6500 Bellinzona, Switzerland.
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Brazzola
authors.affiliation: Ospedale Regionale di Bellinzona e Valli - Bellinzona, Pediatria, Via Ospedale, CH-6500 Bellinzona, Switzerland.
authors.forename: Mario R
authors.initials: MR
authors.lastname: Rossi
keywords: Aspergillosis; Aspergillus fumigatus; Invasive fungal infection; Liposomal amphotericin B; Voriconazole