title: Complete genome characterization of a novel enterovirus type EV-B106 isolated in China, 2012.
abstract: Human enterovirus B106 (EV-B106) is a recently identified member of enterovirus species B. In this study, we report the complete genomic characterization of an EV-B106 strain (148/YN/CHN/12) isolated from an acute flaccid paralysis patient in Yunnan Province, China. The new strain had 79.2-81.3% nucleotide and 89.1-94.8% amino acid similarity in the VP1 region with the other two EV-B106 strains from Bolivia and Pakistan. When compared with other EV serotypes, it had the highest (73.3%) VP1 nucleotide similarity with the EV-B77 prototype strain CF496-99. However, when aligned with all EV-B106 and EV-B77 sequences available from the GenBank database, two major frame shifts were observed in the VP1 coding region, which resulted in substantial (20.5%) VP1 amino acid divergence between the two serotypes. Phylogenetic analysis and similarity plot analysis revealed multiple recombination events in the genome of this strain. This is the first report of the complete genome of EV-B106.
authors.affiliation: 1] Yunnan Center for Disease Control and Prevention, Kunming, Yunnan Province, People's Republic of China [2].
authors.forename: Jingjing
authors.initials: J
authors.lastname: Tang
authors.affiliation: 1] Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention, Shandong Center for Disease Control and Prevention, Jinan, Shandong Province, People's Republic of China [2].
authors.forename: Zexin
authors.initials: Z
authors.lastname: Tao
authors.affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan Province, People's Republic of China.
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Ding
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Ministry of Health Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan Province, People's Republic of China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan Province, People's Republic of China.
authors.forename: Bingjun
authors.initials: B
authors.lastname: Tian
authors.affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan Province, People's Republic of China.
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Zhao
authors.affiliation: Yunnan Center for Disease Control and Prevention, Kunming, Yunnan Province, People's Republic of China.
authors.forename: Lifen
authors.initials: L
authors.lastname: Zhang
authors.affiliation: WHO WPRO Regional Polio Reference Laboratory and Ministry of Health Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China.
authors.forename: Wenbo
authors.initials: W
authors.lastname: Xu
mesh_terms: D001483:Base Sequence; D002681:China; D002874:Chromosome Mapping; D004770:Enterovirus / Q000145:classification* / Q000254:growth & development* / Q000302:isolation & purification; D016679:Genome, Viral / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D020543:Proteome / Q000235:genetics*; D013045:Species Specificity; D014764:Viral Proteins / Q000235:genetics*
chemical_list: D020543:Proteome; D014764:Viral Proteins