title: Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws.
abstract: OBJECTIVE
  The aim of this study was to investigate the expression of Src protein (an osteoclastic factor) in peripheral and central giant cell granulomas (PGCG and CGCGs) of the jaws and the relationship between the expression of this protein and the clinical behavior of these two lesions.
  
  
  METHODS
  Thirty cases of PGCG and 30 cases of CGCG were immunohistochemically stained with Src. A staining-intensity-distribution (SID) score (proportion of stained cells × staining intensity) was used to evaluate immunoreactivity of the protein. Data were analyzed using statistical package for social sciences (SPSS) 17.0.
  
  
  RESULTS
  There were no significant differences in the Src expression and the SID score between PGCG and CGCG. Furthermore, Spearman's rank correlation coefficient showed that there was a significant correlation between Src expression and SID score within both PGCG and CGCG (P < 0.001; r = 0.87 and 0.75, respectively).
  
  
  CONCLUSIONS
  The findings of this study suggest that the multinucleated giant cells share some similarities with osteoclasts and Src protein can be used as a new therapeutic target to inhibit osteoclastic activity. In addition, differences in immunoreactivity of this osteoclastic protein do not reflect different clinical behaviors of PGCG and CGCG.
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran.
authors.forename: Monir Moradzadeh
authors.initials: MM
authors.lastname: Khiavi
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran.
authors.forename: Amir Ala
authors.initials: AA
authors.lastname: Aghbali
authors.affiliation: Department of Pathology, Imam Reza Hospital, Tabriz, Iran.
authors.forename: Monireh
authors.initials: M
authors.lastname: Halimi
authors.affiliation: Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran.
authors.forename: Maryam
authors.initials: M
authors.lastname: Kouhsoltani
authors.affiliation: Department of Pharmaceutical Technology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hamed
authors.initials: H
authors.lastname: Hamishehkar
keywords: Central giant cell granuloma; Src; immunohistochemistry; peripheral giant cell granuloma