title: Prevention of colonic spasm using L-menthol in colonoscopic examination.
abstract: OBJECTIVE
  The detailed efficacy of intraluminal L-menthol for preventing colonic spasm is not known. The aim of this study was to evaluate the effectiveness of L-menthol in preventing colonic spasm during colonoscopy.
  
  
  METHODS
  We analyzed 65 patients (mean age: 71.7 years; 49 men and 16 women) who were administered 0.8% L-menthol (MINCLEA, Nihon Seiyaku, Tokyo, Japan) intraluminally for severe colonic spasm during colonoscopic examination at Kyoto Prefectural University of Medicine between February 2012 and May 2013. The efficacy of L-menthol was defined as the absence of colonic spasm during a period of 30 s, and its effect was evaluated at 30 s, 1 min, and 5 min after administration. Additionally, various characteristics of these patients were analyzed. Twenty-seven patients with severe colonic spasm were administered intraluminal water and assessed as controls.
  
  
  RESULTS
  L-Menthol was effective in preventing colonic spasms in 60.0%, 70.8%, and 46.5% of patients at 30 s, 1 min, and 5 min, respectively. In contrast, water was effective in 22.2%, 29.6%, and 48.1% of patients at 30 s, 1 min, and 5 min, respectively. There was a significant difference about the efficacy at 30 s and 1 min between L-menthol and water (P = 0.0009, P = 0.0006).
  
  
  CONCLUSIONS
  L-Menthol (0.8%) was effective in preventing colonic spasm during colonoscopic examination.
authors.affiliation: Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan, naohisa@koto.kpu-m.ac.jp.
authors.forename: Naohisa
authors.initials: N
authors.lastname: Yoshida
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Ryouhei
authors.initials: R
authors.lastname: Hirose
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ogiso
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Inada
authors.forename: Nilesh
authors.initials: N
authors.lastname: Fernandopulle
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kamada
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Katada
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Uchiyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Handa
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Takagi
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Konishi
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Yagi
authors.forename: Naoki
authors.initials: N
authors.lastname: Wakabayashi
authors.forename: Akio
authors.initials: A
authors.lastname: Yanagisawa
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Itoh
mesh_terms: D000368:Aged; D003108:Colonic Diseases / Q000517:prevention & control*; D003113:Colonoscopy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008610:Menthol / Q000627:therapeutic use*; D010276:Parasympatholytics / Q000627:therapeutic use*; D012189:Retrospective Studies; D013035:Spasm / Q000517:prevention & control*
chemical_list: D010276:Parasympatholytics; D008610:Menthol