title: [Meta-analysis on the relationship between Chinese children's intelligence and excessive iodine].
abstract: OBJECTIVE
  To evaluate the relationship between Chinese children's intelligence and excessive iodine.
  
  
  METHODS
  A computerized literature search was carried out to collect articles published before 2013. The study type was controlled experimental design. And then the statistical analysis was conducted by using RevMan 5.0 software.
  
  
  RESULTS
  A total of 20 controlled studies were included in Meta-analysis. The results showed that iodine content in 601 -900 microg/L (MD = -2.00, 95% CI -3.97, -0.03) and greater than 900 microg/L (MD = -2.77, 95% CI -4.02, -1.52) would reduce the intellectual level of children. Iodine content in 150-300 microg/L (MD = 0.33, 95% CI -0.76, 1.42) and 301-600 microg/L (MD = -1.09, 95% CI -4.80, 2.63) had not statistically significant. The results of dose-response analysis revealed that the possibility of lower intelligence would increase by 57% (OR = 1.57, 95% CI 1.36, 1.78) when there was an increase of 200 microg/L in iodine content.
  
  
  CONCLUSIONS
  Iodine content that was greater than 600 microg/L would reduce the intellectual level of children.
authors.affiliation: School of Public Health and Health Management, Chongqing Medical University, Chongqing 400016, China. rss44@sina.com
authors.forename: Sisi
authors.initials: S
authors.lastname: Ren
authors.affiliation: School of Public Health and Health Management, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhong
mesh_terms: D000293:Adolescent; D002648:Child; D002664:Child Nutritional Physiological Phenomena; D002681:China; D005260:Female; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D007455:Iodine / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D016032:Randomized Controlled Trials as Topic
chemical_list: D007455:Iodine