title: [Effect of cell microenvironment on cell functions associated with tumour promotion and progression].
abstract: To study the tumour-promotion activity of cell environment the transformed embryonic rat fibroblasts (clone CL-1-1) were transfect to immunodeficient mice then the cells of the formed tumour were cultivated (clone CL-1-1). The cells before and after transplantation were compared by morphology, proliferation activity and gap junction intracellular communications. The clone CL-1 cells proliferated much faster than clone CL-1 cells. The CL-1-1 cells had changed morphology structure and unlike CL-1 the contract inhibition was absent in CL-1-1. The number of CL-1 cells in phase G1 was significantly greater than that of CL-1-1 cells, while the number of CL-1-1 cells in G2/M phases was much more the number of CL-1 cells. The activity of gap junction intercellular communications in both cell types was near the same. It was concluded that cell microenvironment act as a tumour-promoter and tumour progression factor in the case of cell transplantation to immunodeficient mice.
authors.forename: I I
authors.initials: II
authors.lastname: Koldin
authors.forename: E M
authors.initials: EM
authors.lastname: Treshchalina
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Sharovskaia
authors.forename: T K
authors.initials: TK
authors.lastname: Dubovaia
authors.forename: V A
authors.initials: VA
authors.lastname: Kobliakov
mesh_terms: D000818:Animals; D002455:Cell Division; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D060833:Cellular Microenvironment / Q000235:genetics; D005347:Fibroblasts / Q000166:cytology* / Q000378:metabolism; D016193:G1 Phase / Q000235:genetics; D051379:Mice; D051381:Rats; D059016:Tumor Microenvironment