title: Preparation of a protected 3-deoxy-D-manno-oct-2-ulosonate glycal donor for the synthesis of β-KDO-containing oligosaccharides.
abstract: A practical method for the synthesis of KDO glycal donors was developed. The prepared KDO donors exhibited excellent disastereoselectivity of glycosylation in a CH2Cl2-CH3CN solvent mixture, which was found to be associated with the isopropylidene protection at the C-4 and C-5 hydroxyls. The synthetic use of the KDO donor was demonstrated in the preparation of β-KDO-containing oligosaccharides.
authors.affiliation: Applied Chemistry Department, National Chiao Tung University , 1001 Ta Hsueh Road, Taiwan.
authors.forename: Tapan Kumar
authors.initials: TK
authors.lastname: Pradhan
authors.forename: Chun Cheng
authors.initials: CC
authors.lastname: Lin
authors.forename: Kwok-Kong Tony
authors.initials: KK
authors.lastname: Mong
mesh_terms: D006031:Glycosylation; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013400:Sugar Acids / Q000737:chemistry*
chemical_list: D009844:Oligosaccharides; D013400:Sugar Acids; C002532:2-keto-3-deoxyoctonate