title: Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action.
abstract: Dietary constituents are shown to play an important role in the development of diabetes. Studies have shown that the fruits of Emblica officinalis Gaertn or Phyllanthus emblica Linn, colloquially known as Indian gooseberry or amla and/or some of its important constituents (including gallic acid, gallotanin, ellagic acid and corilagin), possess anti-diabetic effects through their antioxidant and free radical scavenging properties. Amla has also been reported to prevent/reduce hyperglycemia, cardiac complications, diabetic nephropathy, neuropathy, cataractogenesis and protein wasting. However, clinical trial data with human subjects are limited and preliminary. For the first time this review summarizes the anti-diabetic affects of amla and also addresses the mechanisms mediating these properties.
authors.affiliation: Research and Development cell, Department of Research, Father Muller Medical College, Kankanady, Mangalore, Karnataka, India 575002. msbaliga@gmail.com.
authors.forename: Jason Jerome
authors.initials: JJ
authors.lastname: D'souza
authors.forename: Prema Pancy
authors.initials: PP
authors.lastname: D'souza
authors.forename: Farhan
authors.initials: F
authors.lastname: Fazal
authors.forename: Ashish
authors.initials: A
authors.lastname: Kumar
authors.forename: Harshith P
authors.initials: HP
authors.lastname: Bhat
authors.forename: Manjeshwar Shrinath
authors.initials: MS
authors.lastname: Baliga
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000378:metabolism; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000737:chemistry; D029842:Phyllanthus emblica / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D007004:Hypoglycemic Agents; D010936:Plant Extracts