title: Genetic polymorphisms in IL-2, IL-10, TGF-β1, and IL-2RB and acute rejection in renal transplant patients.
abstract: Acute rejection (AR) remains a concern for kidney transplantation. Cytokines are key mediators in the induction and effector phases of all immune and inflammatory responses. Single nucleotide polymorphisms (SNPs) in cytokines and their receptors may relate to AR. We investigated the relation between AR and SNPs in the genes encoding for IL-2(-330G>T), IL-10(-592C>A and -1082G>A), TGF-β1(915G>C), and IL-2RB(rs228942 C>A and rs228953 C>T) in 325 renal transplant patients during the first year after transplantation. The overall incidence of AR was 15.4%. In multivariate analysis, only the use of induction therapy was correlated with AR (odds ratio 1.9; 95% confidence interval 1.1-3.7; p = 0.04). No statistically significant associations between the SNPs studied and AR were observed. SNPs in the investigated cytokines and their receptors were not associated with the risk of AR. Genotyping patients for these SNPs is unlikely to aid the clinician in adjusting the immunosuppressive therapy for individual patients.
authors.affiliation: Department of Hospital Pharmacy, Erasmus MC, Rotterdam, The Netherlands; Department of Hospital Pharmacy, Beijing Jishuitan Hospital, Beijing, China.
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.forename: Rachida
authors.initials: R
authors.lastname: Bouamar
authors.forename: Ron H N
authors.initials: RH
authors.lastname: Van Schaik
authors.forename: Johan W
authors.initials: JW
authors.lastname: De Fijter
authors.forename: Anders
authors.initials: A
authors.lastname: Hartmann
authors.forename: Martin
authors.initials: M
authors.lastname: Zeier
authors.forename: Klemens
authors.initials: K
authors.lastname: Budde
authors.forename: Dirk R J
authors.initials: DR
authors.lastname: Kuypers
authors.forename: Willem
authors.initials: W
authors.lastname: Weimar
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Hesselink
authors.forename: Teun
authors.initials: T
authors.lastname: Van Gelder
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016753:Interleukin-10 / Q000235:genetics*; D007376:Interleukin-2 / Q000235:genetics*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000235:genetics* / Q000601:surgery; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000235:genetics*; D012189:Retrospective Studies; D012307:Risk Factors; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D007166:Immunosuppressive Agents; D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D053773:Transforming Growth Factor beta1; D016753:Interleukin-10
keywords: acute rejection; cytokine receptor; gene polymorphism; renal transplantation