title: Poly(glycidyl methacrylate)/silver nanocomposite microspheres as a radioiodine scavenger: electrophoretic characterisation of carboxyl- and amine-modified particles.
abstract: Silver nanoparticles possess potent antibacterial properties and have extremely high affinities to radioiodine. For several applications, it is essential to anchor the nanoparticles to microparticles or solid surfaces to make them insoluble while retaining their unique properties. This current work is related to the design of anionic and cationic macroporous polymer microspheres based on poly(glycidyl methacrylate) (PGMA) obtained using a multistep swelling polymerisation. According to scanning electron microscopy, the microspheres were monodisperse in size and 4.2 μm in diameter. The presence of the carboxyl and amino groups in the PGMA-COOH and PGMA-NH2 microspheres was confirmed by FT-IR spectroscopy. Capillary electrophoresis (CE) and pressure-assisted capillary electrophoresis (PACE) were used to study the electrophoretic behaviour of both types of microparticles. The electrophoretic mobility of the microparticles was changed into ζ potential using Smoluchowski modelling. Finally, silver-containing microspheres were prepared by reducing silver nitrate in the presence of the microspheres, and they proved effective for scavenging radioiodide ions from a model medium.
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského Sq. 2, 162 06 Prague 6, Czech Republic.
authors.forename: Hana
authors.initials: H
authors.lastname: Macková
authors.affiliation: Faculté de Pharmacie (UMR 8612 - Institut Gallien Paris Sud), Université Paris Sud, Châtenay-Malabry, France.
authors.forename: Farid
authors.initials: F
authors.lastname: Oukacine
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského Sq. 2, 162 06 Prague 6, Czech Republic.
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Plichta
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského Sq. 2, 162 06 Prague 6, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Hrubý
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského Sq. 2, 162 06 Prague 6, Czech Republic.
authors.forename: Jan
authors.initials: J
authors.lastname: Kučka
authors.affiliation: Faculté de Pharmacie (UMR 8612 - Institut Gallien Paris Sud), Université Paris Sud, Châtenay-Malabry, France.
authors.forename: Myriam
authors.initials: M
authors.lastname: Taverna
authors.affiliation: Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Heyrovského Sq. 2, 162 06 Prague 6, Czech Republic. Electronic address: horak@imc.cas.cz.
authors.forename: Daniel
authors.initials: D
authors.lastname: Horák
mesh_terms: D000588:Amines / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D007457:Iodine Radioisotopes / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D053761:Nanocomposites; D009994:Osmolar Concentration; D011109:Polymethacrylic Acids / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000588:Amines; D007457:Iodine Radioisotopes; D011109:Polymethacrylic Acids; C042535:polyglycidyl methacrylate; D012834:Silver
keywords: Electrophoretic characterisation; Glycidyl methacrylate; Microspheres; Silver