title: Preparation and characterization of a sulindac sensor based on PVC/TOA-SUL membrane.
abstract: A potentiometric sulindac sensitive sensor based on tetraoctylammonium (Z)-5-fluoro-2-methyl-1-[[p-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetate (TOA-SUL) was described. The electrode responded with sensitivity of 57.5±1.6mV decade(-1) over the linear range 5×10(-5)-1×10(-2)mol L(-1) at pH6.0-9.0. It had the limit of detection 1.4×10(-5)mol L(-1), a fast response time of 13s and showed clear discrimination of sulindac ions from several inorganic and organic compounds and also amino acids. This electrode did not contain any inner solutions, so it was easy and comfortable to use. The proposed sensor was used to determine sulindac in clear solution and in urine sample solution.
authors.affiliation: Faculty of Chemistry, Maria Curie-Skłodowska University, 5 M. Curie-Skłodowskiej Square, 20-031 Lublin, Poland. Electronic address: j.lenik@poczta.umcs.lublin.pl.
authors.forename: Joanna
authors.initials: J
authors.lastname: Lenik
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000970:Antineoplastic Agents / Q000032:analysis* / Q000652:urine; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry; D008567:Membranes, Artificial; D010968:Plasticizers / Q000737:chemistry; D011143:Polyvinyl Chloride / Q000737:chemistry*; D011199:Potentiometry; D013467:Sulindac / Q000032:analysis* / Q000737:chemistry* / Q000652:urine
chemical_list: D000596:Amino Acids; D000970:Antineoplastic Agents; D007477:Ions; D008567:Membranes, Artificial; D010968:Plasticizers; D013467:Sulindac; D011143:Polyvinyl Chloride
keywords: Ion-selective electrode; Polymer membrane; Sulindac; Tetraoctylammonium salt; Urine