title: Severe Staphylococcus aureus infection in three pediatric intensive care units: analysis of cases of necrotizing pneumonia.
abstract: Staphylococcus aureus frequently affects human beings. Among clinical manifestations, necrotizing pneumonia is associated with a high mortality rate. Our objective is to describe the progress of severe Staphylococcus aureus infections in three intensive care units and analyze cases ofnecrotizing pneumonia in the period ranging from January 2011 to March 2013. Forty-three patients were studied, 76.7% had a community-acquired infection, and 31 had community-acquired methicillin-resistant Staphylococcus aureus. The main reason for admission was respiratory failure. Bacteremia was confirmed in 55.8% of cases. Mechanical ventilation was required in 86% of admitted patients, while 27 patients developed septic shock. The length of stay in the intensive care unit was 13 (5-25) days, and the mortality rate was 14%. Necrotizing pneumonia was observed in 51% of cases. Conclusion. A high rate of community-acquired infection was identified. Necrotizing pneumonia was associated with a worse clinical course.
authors.affiliation: Servicio de Terapia Intensiva, Hospital General de Niños Pedro de Elizalde.
authors.forename: Pedro
authors.initials: P
authors.lastname: Taffarel
authors.affiliation: Servicio de Terapia Intensiva, Hospital de Niños de la Santísima Trinidad, Córdoba.
authors.forename: Germán
authors.initials: G
authors.lastname: Bonetto
authors.affiliation: Servicio de Terapia Intensiva, Hospital General de Niños Pedro de Elizalde.
authors.forename: Matías
authors.initials: M
authors.lastname: Penazzi
authors.affiliation: Servicio de Terapia Intensiva, Hospital General de Niños Pedro de Elizalde.
authors.forename: Facundo
authors.initials: F
authors.lastname: Jorro Barón
authors.affiliation: Servicio de Terapia Intensiva, Hospital de Niños de la Santísima Trinidad, Córdoba.
authors.forename: Silvia
authors.initials: S
authors.lastname: Saenz
authors.affiliation: Servicio de Infectología, Hospital del Niño de San Justo, San Justo.
authors.forename: Macarena
authors.initials: M
authors.lastname: Uranga
authors.affiliation: Servicio de Terapia Intensiva, Hospital del Niño de San Justo, San Justo.
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mari
authors.affiliation: Servicio de Microbiología, Hospital General de Niños Pedro de Elizalde.
authors.forename: Rosana
authors.initials: R
authors.lastname: Pereda
authors.affiliation: Servicio de Terapia Intensiva, Hospital General de Niños Pedro de Elizalde.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Debaisi
mesh_terms: D002648:Child; D006760:Hospitalization; D006801:Humans; D015278:Intensive Care Units, Pediatric; D009336:Necrosis; D011023:Pneumonia, Staphylococcal / Q000473:pathology*; D011446:Prospective Studies; D012189:Retrospective Studies; D012720:Severity of Illness Index