title: Binding modes of chain arylpiperazines to 5-HT1a, 5-HT2a and 5-HT7 receptors.
abstract: An overview of docking models of chain arylpiperazines to different subtypes of serotonin receptors belonging to the GPCR family is presented. The theory of a ligand-receptor interaction has been briefly summarized. The review covers more than twenty models, beginning with the early models of a ligand interaction with the 5-HT1A and 5-HT2A receptor, and ending with a ligand-5-HT7 receptor docking studies.
authors.forename: Anna
authors.initials: A
authors.lastname: Bielenica
authors.forename: Anna E
authors.initials: AE
authors.lastname: Kozioł
authors.affiliation: Department of Medical Chemistry, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.
authors.forename: Marta
authors.initials: M
authors.lastname: Struga
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D010879:Piperazines / Q000737:chemistry* / Q000494:pharmacology; D044282:Receptor, Serotonin, 5-HT1A / Q000737:chemistry* / Q000378:metabolism; D044402:Receptor, Serotonin, 5-HT2A / Q000737:chemistry* / Q000378:metabolism; D011985:Receptors, Serotonin / Q000737:chemistry* / Q000378:metabolism; D058825:Serotonin 5-HT1 Receptor Agonists / Q000737:chemistry / Q000494:pharmacology; D058829:Serotonin 5-HT1 Receptor Antagonists / Q000737:chemistry / Q000494:pharmacology; D058826:Serotonin 5-HT2 Receptor Agonists / Q000737:chemistry / Q000494:pharmacology; D058830:Serotonin 5-HT2 Receptor Antagonists / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D010879:Piperazines; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D058825:Serotonin 5-HT1 Receptor Agonists; D058829:Serotonin 5-HT1 Receptor Antagonists; D058826:Serotonin 5-HT2 Receptor Agonists; D058830:Serotonin 5-HT2 Receptor Antagonists; C104425:serotonin 7 receptor; D044282:Receptor, Serotonin, 5-HT1A