title: Is muscle energy production disturbed in exertional heat stroke?
abstract: BACKGROUND
  Exertional heat stroke (EHS) is a life-threatening disease that shares some clinical similarities with malignant hyperthermia (MH). By use of (31)Phosphorus magnetic resonance spectroscopy (MRS), EHS patients with MH susceptibility and MH patients shared common metabolic abnormalities. The aim of this study was to determine whether subjects who suffered from an EHS episode had disturbed muscle energetics.
  
  
  METHODS
  This retrospective study was performed within the French database of military subjects that were explored from 2004 to 2010 after they suffered an EHS. All subjects had both in vitro contracture test to determine their MH susceptibility and (31)Phosphorus MRS at 4.7 Tesla to assess muscle energetics by means of MRS score, a composite score corresponding to the sum of metabolic abnormalities recorded during a standardized rest-exercise-recovery protocol.
  
  
  RESULTS
  437 subjects were investigated and 32.5% of them exhibited abnormal MRS score. MRS score did not segregate subjects on demographic, clinical, or biological grounds. No clear correlation could be done between MH status and MRS score.
  
  
  CONCLUSIONS
  These results did not confirm the potential relationship between calcium homeostasis and muscle energetics previously reported. However, muscle energy production was disturbed in a significant number of EHS subjects.
authors.affiliation: Laveran Military Teaching Hospital, BP 60149, 13384 Marseille Cedex 13, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Sagui
authors.affiliation: Paris Fire Brigade Health Service, 92400 Courbevoie, France.
authors.forename: Amandine
authors.initials: A
authors.lastname: Abriat
authors.affiliation: Center for Magnetic Resonance in Biology and Medicine, Aix Marseille University, CNRS CRMBM UMR 7339, 13385 Marseille, France.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Kozak-Ribbens
authors.affiliation: Center for Magnetic Resonance in Biology and Medicine, Aix Marseille University, CNRS CRMBM UMR 7339, 13385 Marseille, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Foutrier-Morello
authors.affiliation: Center for Magnetic Resonance in Biology and Medicine, Aix Marseille University, CNRS CRMBM UMR 7339, 13385 Marseille, France.
authors.forename: Monique
authors.initials: M
authors.lastname: Bernard
authors.affiliation: Army Biomedical Research Institute, 24 av du Maquis de Grésivaudan, 38702 La Tronche Cedex, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Canini
authors.affiliation: Laveran Military Teaching Hospital, BP 60149, 13384 Marseille Cedex 13, France.
authors.forename: Christian
authors.initials: C
authors.lastname: Brosset
authors.affiliation: Center for Magnetic Resonance in Biology and Medicine, Aix Marseille University, CNRS CRMBM UMR 7339, 13385 Marseille, France.
authors.forename: David
authors.initials: D
authors.lastname: Bendahan
mesh_terms: D000328:Adult; D004734:Energy Metabolism / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D018883:Heat Stroke / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008889:Military Personnel; D009119:Muscle Contraction / Q000502:physiology*; D012189:Retrospective Studies; D055815:Young Adult