title: Protective effect of carvacrol on acute lung injury induced by lipopolysaccharide in mice.
abstract: Carvacrol, the major component of Plectranthus amboinicus, has been known to exhibit anti-inflammatory activities. The aim of this study was to investigate the effects of carvacrol on lipopolysaccharide (LPS)-induced endotoxemia and acute lung injury (ALI) in mice. Mice were injected intraperitoneally (i.p.) with LPS and the mortality of mice for 7 days were observed twice a day. Meanwhile, the protective effect of carvacrol (20, 40 or 80 mg/kg) on LPS-induced endotoxemia were detected. Using an experimental model of LPS-induced ALI, we examined the effect of carvacrol in resolving lung injury. The results showed that carvacrol could improve survival during lethal endotoxemia and attenuate LPS-induced ALI in mice. The anti-inflammatory mechanisms of carvacrol may be due to its ability to inhibit NF-κB and MAPKs signaling pathways, thereby inhibiting inflammatory cytokines TNF-α, IL-6 and IL-1β production.
authors.affiliation: Guangdong Haid Institute of Animal Husbandry and Veterinary, Guangzhou, Guangdong, 510000, China, fxs_2005@hotmail.com.
authors.forename: Xiaosheng
authors.initials: X
authors.lastname: Feng
authors.forename: Aiqing
authors.initials: A
authors.lastname: Jia
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000081007:Cymenes; D004305:Dose-Response Relationship, Drug; D019446:Endotoxemia / Q000139:chemically induced; D007249:Inflammation / Q000378:metabolism; D007274:Injections, Intraperitoneal; D053583:Interleukin-1beta / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000737:chemistry*; D020935:MAP Kinase Signaling System; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D039821:Monoterpenes / Q000494:pharmacology*; D009504:Neutrophils / Q000473:pathology; D031346:Plectranthus / Q000737:chemistry; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000081007:Cymenes; D053583:Interleukin-1beta; D015850:Interleukin-6; D008070:Lipopolysaccharides; D039821:Monoterpenes; D014409:Tumor Necrosis Factor-alpha; C073316:carvacrol