title: Yield of screening colonoscopy in first-degree relatives of patients with serrated polyposis syndrome.
abstract: OBJECTIVE
  We aimed to evaluate the diagnostic yield of screening colonoscopies in first-degree relatives (FDRs) of patients with serrated polyposis syndrome (SPS).
  
  
  BACKGROUND
  Patients with SPS are at an increased risk for colorectal cancer. Although inheritance patterns are unknown, FDRs of these patients have an increased risk for both colorectal cancer and SPS. Prospective studies evaluating the yield of screening colonoscopies in this group are however scarce. This information would be useful to evaluate a possible mode of inheritance and to investigate whether screening colonoscopies are justified in this group.
  
  
  METHODS
  FDR of patients with SPS were invited to undergo colonoscopy. The diagnostic yield was expressed by the number of FDRs with at least 1 significant polyp relative to the total number of included FDRs. Significant polyps were defined adenomas, traditional serrated adenomas, sessile serrated adenoma/polyp, or proximal hyperplastic polyp. Tissue specimens were reviewed by one expert pathologist.
  
  
  RESULTS
  Seventy-seven FDRs underwent colonoscopy (median age 52 y; interquartile range, 41 to 60). Colorectal cancer was not diagnosed. One or more significant polyps were detected in 43% of FDRs. No differences based on age, gender, or familial relationship were observed in the detection of polyps. Seven first-degree (9%) relatives had multiple polyps (≥5). Eleven (14%) FDRs fulfilled SPS WHO-criterion 2, of whom 1 sibling also met SPS WHO-criterion 3.
  
  
  CONCLUSIONS
  The yield of a single screening colonoscopy in FDRs of patients with serrated polyposis is substantial, warranting a colonoscopy screening program for these individuals.
authors.affiliation: Departments of *Gastroenterology and Hepatology ‡Clinical Genetics §Pathology, Academic Medical Centre, Amsterdam †Department of Gastroenterology and Hepatology, University Medical Centre, Groningen, the Netherlands.
authors.forename: Yark
authors.initials: Y
authors.lastname: Hazewinkel
authors.forename: Jan-Jacob
authors.initials: JJ
authors.lastname: Koornstra
authors.forename: Karam S
authors.initials: KS
authors.lastname: Boparai
authors.forename: Theo A M
authors.initials: TA
authors.lastname: van Os
authors.forename: Kristien M A J
authors.initials: KM
authors.lastname: Tytgat
authors.forename: Susanne
authors.initials: S
authors.lastname: Van Eeden
authors.forename: Paul
authors.initials: P
authors.lastname: Fockens
authors.forename: Evelien
authors.initials: E
authors.lastname: Dekker
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000235:genetics* / Q000473:pathology*; D000328:Adult; D000368:Aged; D003110:Colonic Neoplasms / Q000473:pathology*; D003113:Colonoscopy; D055088:Early Detection of Cancer; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010375:Pedigree; D011446:Prospective Studies