title: Disarmed by density: A glycolytic break for immunostimulatory dendritic cells?
abstract: We observed a cell concentration-dependent differentiation switch among cultured dendritic cells (DCs) triggered by lactic acid, a product of glycolytic metabolism. In particular, while interleukin (IL)-12, IL-23, and tumor necrosis factor α (TNFα)-producing, migratory DCs developed in sparse cultures, IL-10-producing, non-migratory DCs differentiated in dense cultures. This points to a novel opportunity for tailoring DC-based anticancer therapies through metabolism modulation in developing DCs.
authors.affiliation: Department of Microbiology; Tumor and Cell Biology; Karolinska Institutet; Stockholm, Sweden.
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Nasi
authors.affiliation: Department of Microbiology; Tumor and Cell Biology; Karolinska Institutet; Stockholm, Sweden.
authors.forename: Bence
authors.initials: B
authors.lastname: Rethi
keywords: dendritic cell; dendritic cell differentiation; dendritic cell vaccine; glycolysis; lactic acid