title: Polypeptide films via N-carboxyanhydride ring-opening polymerization (NCA-ROP): past, present and future.
abstract: The formation of surface-grafted polypeptide films and interfaces via N-carboxyanhydride ring-opening polymerization (NCA-ROP) holds great potential for the facile preparation of next-generation multifunctional and responsive materials with excellent biocompatibility, biodegradability, tunable conformations and chemical functionalities. Therefore, the aim of this feature article is to provide a topical review of developments in the area of polypeptide films derived through NCA-ROP. It is evident that studies reported thus far have only started to unveil the full potential of peptide-based interfaces and materials, and with continued advancements it is anticipated that the strategic combination of NCA-ROP with modern synthetic chemistries will continue to yield versatile platforms for broader applications in the fields of polymer therapeutics, tissue engineering, (bio)nanocoatings, (bio)chemosensors, catalysis and separation technologies.
authors.affiliation: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, VIC 3010, Australia. gregghq@unimelb.edu.au.
authors.forename: Steven Harris
authors.initials: SH
authors.lastname: Wibowo
authors.forename: Adrian
authors.initials: A
authors.lastname: Sulistio
authors.forename: Edgar H H
authors.initials: EH
authors.lastname: Wong
authors.forename: Anton
authors.initials: A
authors.lastname: Blencowe
authors.forename: Greg G
authors.initials: GG
authors.lastname: Qiao
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D000812:Anhydrides; D001672:Biocompatible Materials; D010446:Peptide Fragments; D011108:Polymers