title: Do metoclopramide and ondansetrone alter mivacurium-induced neuromuscular blockade? - a randomised trial.
abstract: BACKGROUND
  We aimed to investigate the effects of metoclopramide and ondansetrone on mivacurium neuromuscular blockade.
  
  
  METHODS
  Seventy five, ASA I-II patients, aged 18-65 and scheduled for elective surgery requiring tracheal intubation were included in the study. The patients received metoclopramide 10 mg, ondansetrone 4 mg or normal saline 5 mL; group M, group O, group NS (n=25), respectively. Before anesthesia study drugs were administered in a volume of 5 mL. The level of plasma cholinesterase were obtained before and 5 minutes after the administration of study drugs and 5 minutes after the administration of mivacurium. Onset time, T25, T75, T25-75, T90 levels were compared with each other and differences between each patients were investigated. After recording T90, the study was terminated and surgery was started.
  
  
  RESULTS
  Onset time was significantly shorter in group M, than the other two groups. Onset time in group O was significantly shorter than in group NS. In Group M T25, T75, T90 and recovery indices were significantly greater than in Group NS (p<0.001). In Group O T25, T75 were greater than Group NS (p<0.01 and p<0.05, respectively). In Group M T75, T90 and emergence indices were significantly higher than Group O (p<0.001, p<0.01, p<0.001, respectively). In Groups M and O, plasma cholinesterase levels decreased significantly (p<0.001) after administration of study drugs and mivacurium. Plasma cholinesterase also was reduced in Group NS 5 minutes after the administration of mivacurium (p<0.001).
  
  
  CONCLUSIONS
  Ondansetrone is believed to be more reliable agent than metoclopramide when used with mivacurium.
authors.affiliation: Anesthesiology and Reanimation Department, Medical Faculty, Uludag University, Bursa, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tercan
authors.affiliation: Anesthesiology and Reanimation Department, Medical Faculty, Uludag University, Bursa, Turkey. Electronic address: basagan@uludag.edu.tr.
authors.forename: Esra Mercanoglu
authors.initials: EM
authors.lastname: Efe
authors.affiliation: Anesthesiology and Reanimation Department, Medical Faculty, Uludag University, Bursa, Turkey.
authors.forename: Gurkan
authors.initials: G
authors.lastname: Turker
authors.affiliation: Anesthesiology and Reanimation Department, Medical Faculty, Uludag University, Bursa, Turkey.
authors.forename: Fatma Nur
authors.initials: FN
authors.lastname: Kaya
authors.affiliation: Anesthesiology and Reanimation Department, Medical Faculty, Uludag University, Bursa, Turkey.
authors.forename: Belgin
authors.initials: B
authors.lastname: Yavascaoglu
authors.affiliation: Biochemistry Department, Medical Faculty, Uludag University, Bursa, Turkey.
authors.forename: Yesim
authors.initials: Y
authors.lastname: Ozarda
authors.affiliation: Anesthesiology and Reanimation Department, Medical Faculty, Uludag University, Bursa, Turkey.
authors.forename: Elif Basagan
authors.initials: EB
authors.lastname: Mogol
mesh_terms: D000328:Adult; D002802:Cholinesterases / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D008875:Middle Aged; D000077590:Mivacurium; D019148:Neuromuscular Blockade; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D017294:Ondansetron / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D017294:Ondansetron; D000077590:Mivacurium; D002802:Cholinesterases; D008787:Metoclopramide
keywords: Anesthesia; Blockade; Metoclopramide; Mivacurium; Neuromusculary; Ondansetrone