title: Toll‑like receptor 2 promotes bacterial clearance during the initial stage of pulmonary infection with Acinetobacter baumannii.
abstract: Toll‑like receptor 2 (TLR2) has been identified as a sensor for bacterial lipoprotein. To determine the role of TLR2 in host defense against Acinetobacter baumannii infection, wild‑type (WT) and TLR2‑deficient mice were infected intranasally with A. baumannii. Body weight, cytokine and chemokine levels in bronchoalveolar (BAL) fluid and lung histopathology were examined. Body weight changes in TLR2‑deficient mice were comparable to those of WT mice throughout the experimental period. However, TLR2‑deficient mice exhibited an increased bacterial load in the lungs and increased levels of interleukin‑6 and chemokine (C‑X‑C motif) ligand 2 in BAL fluids compared with WT mice 1 day after infection. Histopathological features of lung tissue in WT and TLR2‑deficient mice were comparable between WT and TLR2‑deficient mice. Results of the present study demonstrate that TLR2 may have a minimal role in the host defense against A. baumannii at the early stages of infection.
authors.affiliation: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151‑742, Republic of Korea.
authors.forename: Chang-Hwan
authors.initials: CH
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea.
authors.forename: Dong-Jae
authors.initials: DJ
authors.lastname: Kim
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea.
authors.forename: Sang-Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea.
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Jeong
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea.
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kang
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea.
authors.forename: Jun-Young
authors.initials: JY
authors.lastname: Lee
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea.
authors.forename: Jin-A
authors.initials: JA
authors.lastname: Choi
authors.affiliation: Department of Internal Medicine, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea.
authors.forename: Sun-Jung
authors.initials: SJ
authors.lastname: Kwon
authors.affiliation: Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 151‑742, Republic of Korea.
authors.forename: Jae-Hak
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Biochemistry, College of Medicine, Konyang University, Daejeon 302‑718, Republic of Korea.
authors.forename: Jong-Hwan
authors.initials: JH
authors.lastname: Park
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology* / Q000473:pathology*; D040981:Acinetobacter baumannii / Q000502:physiology*; D000818:Animals; D001835:Body Weight; D018893:Bronchoalveolar Lavage; D018925:Chemokines / Q000096:biosynthesis; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D012141:Respiratory Tract Infections / Q000382:microbiology* / Q000473:pathology*; D051195:Toll-Like Receptor 2 / Q000172:deficiency / Q000378:metabolism*
chemical_list: D018925:Chemokines; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2