title: Hormonal signaling in the gut.
abstract: The gut is anatomically positioned to play a critical role in the regulation of metabolic homeostasis, providing negative feedback via nutrient sensing and local hormonal signaling. Gut hormones, such as cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), are released following a meal and act on local receptors to regulate glycemia via a neuronal gut-brain axis. Additionally, jejunal nutrient sensing and leptin action are demonstrated to suppress glucose production, and both are required for the rapid antidiabetic effect of duodenal jejunal bypass surgery. Strategies aimed at targeting local gut hormonal signaling pathways may prove to be efficacious therapeutic options to improve glucose control in diabetes.
authors.affiliation: Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7; Departments of Physiology, University of Toronto, Toronto, Ontario M5S 1A8.
authors.forename: Clémence D
authors.initials: CD
authors.lastname: Côté
authors.affiliation: Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7; Departments of Physiology, University of Toronto, Toronto, Ontario M5S 1A8.
authors.forename: Melika
authors.initials: M
authors.lastname: Zadeh-Tahmasebi
authors.affiliation: Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7; Departments of Physiology, University of Toronto, Toronto, Ontario M5S 1A8.
authors.forename: Brittany A
authors.initials: BA
authors.lastname: Rasmussen
authors.affiliation: Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7; Departments of Medicine, University of Toronto, Toronto, Ontario M5S 1A8.
authors.forename: Frank A
authors.initials: FA
authors.lastname: Duca
authors.affiliation: Toronto General Research Institute, University Health Network, Toronto, Ontario M5G 1L7; Departments of Physiology, University of Toronto, Toronto, Ontario M5S 1A8; Departments of Medicine, University of Toronto, Toronto, Ontario M5S 1A8; Departments of Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario M5G 2C4, Canada. Electronic address: tony.lam@uhnres.utoronto.ca.
authors.forename: Tony K T
authors.initials: TKT
authors.lastname: Lam
mesh_terms: D005753:Gastric Mucosa / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction
chemical_list: D005768:Gastrointestinal Hormones
keywords: Bariatric Surgery; Diabetes; Fatty Acid; Food Intake; Glucose Metabolism; Hormones; Intestine