title: Orientation-independent rapid pulsatile flow measurement using dual-angle Doppler OCT.
abstract: Doppler OCT (DOCT) can provide blood flow velocity information which is valuable for investigation of microvascular structure and function. However, DOCT is only sensitive to motion parallel with the imaging beam, so that knowledge of flow direction is needed for absolute velocity determination. Here, absolute volumetric flow is calculated by integrating velocity components perpendicular to the B-scan plane. These components are acquired using two illumination beams with a predetermined angular separation, produced by a delay encoded technique. This technology enables rapid pulsatile flow measurement from single B-scans without the need for 3-D volumetric data or knowledge of blood vessel orientation.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 USA.
authors.forename: Lindsy M
authors.initials: LM
authors.lastname: Peterson
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 USA.
authors.forename: Shi
authors.initials: S
authors.lastname: Gu
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 USA.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Jenkins
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 USA.
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Rollins
keywords: (110.4500) Optical coherence tomography; (170.3880) Medical and biological imaging