title: SIRT1 metabolic actions: Integrating recent advances from mouse models.
abstract: SIRT1 has attracted a lot of interest since it was discovered as a mammalian homolog of Sir2, a protein that influences longevity in yeast. Intensive early research suggested a key role of SIRT1 in mammalian development, metabolic flexibility and oxidative metabolism. However, it is the growing body of transgenic models that are allowing us to clearly define the true range of SIRT1 actions. In this review we aim to summarize the most recent lessons that transgenic animal models have taught us about the role of SIRT1 in mammalian metabolic homeostasis and lifespan.
authors.affiliation: Nestlé Institute of Health Sciences S.A., EPFL campus, Quartier de l'Innovation, Bâtiment G, CH-1015 Lausanne, Switzerland.
authors.forename: Marie
authors.initials: M
authors.lastname: Boutant
authors.affiliation: Nestlé Institute of Health Sciences S.A., EPFL campus, Quartier de l'Innovation, Bâtiment G, CH-1015 Lausanne, Switzerland.
authors.forename: Carles
authors.initials: C
authors.lastname: Cantó
keywords: Energy homeostasis; Insulin resistance; SIRT1; Transgenic models