title: Extremely low frequency magnetic field (50 Hz, 0.5 mT) reduces oxidative stress in the brain of gerbils submitted to global cerebral ischemia.
abstract: Magnetic field as ecological factor has influence on all living beings. The aim of this study was to determine if extremely low frequency magnetic field (ELF-MF, 50 Hz, 0.5 mT) affects oxidative stress in the brain of gerbils submitted to 10-min global cerebral ischemia. After occlusion of both carotid arteries, 3-month-old gerbils were continuously exposed to ELF-MF for 7 days. Nitric oxide and superoxide anion production, superoxide dismutase activity and index of lipid peroxidation were examined in the forebrain cortex, striatum and hippocampus on the 7(th) (immediate effect of ELF-MF) and 14(th) day after reperfusion (delayed effect of ELF-MF). Ischemia per se increased oxidative stress in the brain on the 7(th) and 14(th) day after reperfusion. ELF-MF also increased oxidative stress, but to a greater extent than ischemia, only immediately after cessation of exposure. Ischemic gerbils exposed to ELF-MF had increased oxidative stress parameters on the 7(th) day after reperfusion, but to a lesser extent than ischemic or ELF-MF-exposed animals. On the 14(th) day after reperfusion, oxidative stress parameters in the brain of these gerbils were mostly at the control levels. Applied ELF-MF decreases oxidative stress induced by global cerebral ischemia and thereby reduces possible negative consequences which free radical species could have in the brain. The results presented here indicate a beneficial effect of ELF-MF (50 Hz, 0.5 mT) in the model of global cerebral ischemia.
authors.affiliation: Institute for Biological Research, University of Belgrade, Belgrade, Serbia.
authors.forename: Snežana
authors.initials: S
authors.lastname: Rauš Balind
authors.affiliation: Institute for Medical Research, Military Medical Academy, Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Selaković
authors.affiliation: Department of Physiology and Biochemistry, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
authors.forename: Lidija
authors.initials: L
authors.lastname: Radenović
authors.affiliation: Institute for Biological Research, University of Belgrade, Belgrade, Serbia.
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Prolić
authors.affiliation: Institute for Biological Research, University of Belgrade, Belgrade, Serbia.
authors.forename: Branka
authors.initials: B
authors.lastname: Janać
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000528:radiation effects*; D002545:Brain Ischemia / Q000628:therapy*; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000528:radiation effects; D005849:Gerbillinae; D015227:Lipid Peroxidation / Q000528:radiation effects; D055909:Magnetic Field Therapy / Q000379:methods*; D060526:Magnetic Fields; D008297:Male; D018384:Oxidative Stress / Q000528:radiation effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: D013481:Superoxides; D013482:Superoxide Dismutase