title: Prevalence of Anti-JC Virus Antibody in Multiple Sclerosis Patients in Kuwait.
abstract: Background. Multiple sclerosis (MS) therapeutics entered a new era after the development of anti-JC virus (anti-JCV) antibody assay that assesses the risk of development of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab. Objective. To determine the prevalence of anti-JCV antibody among MS patients in Kuwait. Methods. Using the national MS registry, demographics and disease characteristics of MS patients who were screened for anti-JC virus antibody were collected. The prevalence of anti-JCV antibody seropositivity and its association with demographic and disease characteristics were evaluated. Results. Out of 110 screened MS patients for anti-JCV antibodies, 65.5% were females. Mean age and disease duration were 29.23 ± 8.55 and 5.39 ± 5.04 years, respectively. 47.3% of patients were already on natalizumab and 52.7% of patients were screened for stratification to either natalizumab or a different Disease Modifying Therapy (DMT). The overall prevalence of anti-JC virus antibody was 40%. Gender (P = 0.69), disease duration (P = 0.11), and number of natalizumab infusions (P = 0.64) were not associated with seropositivity. Patients aged ≥30 years were more likely to be seropositive (P = 0.01). Conclusion. The prevalence of anti-JCV antibody is slightly lower than what is reported in published studies. Seropositivity was associated with an increasing age of MS patients.
authors.affiliation: Division of Neurology, Department of Medicine, Amiri Hospital, Arabian Gulf Street, 13041 Kuwait City, Kuwait.
authors.forename: S
authors.initials: S
authors.lastname: Lamdhade
authors.affiliation: Division of Neurology, Department of Medicine, Amiri Hospital, Arabian Gulf Street, 13041 Kuwait City, Kuwait.
authors.forename: A
authors.initials: A
authors.lastname: Ashkanani
authors.affiliation: Division of Neurology, Department of Medicine, Amiri Hospital, Arabian Gulf Street, 13041 Kuwait City, Kuwait ; Neurology Clinic, Dasman Diabetes Institute, P.O. Box 1180, 15462 Dasman, Kuwait.
authors.forename: R
authors.initials: R
authors.lastname: Alroughani