title: Comparison of 5-aminolevulinic acid photodynamic therapy and red light for treatment of photoaging.
abstract: OBJECTIVE
  The aim of this pilot study was to compare the efficacy of ALA-PDT and red light alone in the treatment of photoaging.
  
  
  METHODS
  A total of 14 adults with photoaging skin were recruited. ALA-PDT or red light alone was applied to the forearm extensor. Before and after treatment, the treated sites were examined by dermoscopy, the changes in straum corneum (SC) hydration, transepidermal water loss (TEWL), and the L*a*b* values were measured, and microscopic examination of collagens and elastins was performed.
  
  
  RESULTS
  After ALA-PDT or red light illumination, the appearance of photoaging lesions improved, SC hydration increased and TEWL decreased. These changes in the ALA-PDT group were more obvious than those in the red light group. No significant change was noticed in the L*a*b* values in both groups. The signs of typical solar elastosis damage were improved in both groups.
  
  
  CONCLUSIONS
  ALA-PDT showed better skin rejuvenation effect than red light alone.
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Ji
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai, China.
authors.forename: Ling-Lin
authors.initials: LL
authors.lastname: Zhang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai, China.
authors.forename: Hui-Lin
authors.initials: HL
authors.lastname: Ding
authors.affiliation: Department of Dermatology, Huadong Hospital, Shanghai, China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Wang
authors.affiliation: MOE Key Laboratory of OptoElectronic Science and Technology for Medicine, Fujian Normal University, Fuzhou, China; College of Engineering and Applied Science, University of Colorado Denver, CO, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai, China.
authors.forename: Xiao-Xin
authors.initials: XX
authors.lastname: Wang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai, China.
authors.forename: Pei-Ru
authors.initials: PR
authors.lastname: Wang
authors.affiliation: Shanghai Skin Diseases Hospital, Shanghai, China. Electronic address: xlwang2001@aliyun.com.
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D003116:Color; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use; D010789:Phototherapy / Q000379:methods; D010865:Pilot Projects; D012060:Rejuvenation / Q000502:physiology*; D012867:Skin / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects*; D012879:Skin Physiological Phenomena / Q000187:drug effects / Q000528:radiation effects*; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid
keywords: 5-Aminolevulinic acid; Photoaging; Photodynamic therapy; Red light