title: ESC Working Group on Myocardial Function Position Paper: how to study the right ventricle in experimental models.
abstract: The right ventricle has become an increasing focus in cardiovascular research. In this position paper, we give a brief overview of the specific pathophysiological features of the right ventricle, with particular emphasis on functional and molecular modifications as well as therapeutic strategies in chronic overload, highlighting the differences from the left ventricle. Importantly, we put together recommendations on promising topics of research in the field, experimental study design, and functional evaluation of the right ventricle in experimental models, from non-invasive methodologies to haemodynamic evaluation and ex vivo set-ups.
authors.affiliation: Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Al. Prof. Hernani Monteiro, 4200 319, Porto, Portugal.
authors.forename: Adelino F
authors.initials: AF
authors.lastname: Leite-Moreira
authors.forename: André P
authors.initials: AP
authors.lastname: Lourenço
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Balligand
authors.forename: Johann
authors.initials: J
authors.lastname: Bauersachs
authors.forename: Angela
authors.initials: A
authors.lastname: Clerk
authors.forename: Leon J
authors.initials: LJ
authors.lastname: De Windt
authors.forename: Stephane
authors.initials: S
authors.lastname: Heymans
authors.forename: Denise
authors.initials: D
authors.lastname: Hilfiker-Kleiner
authors.forename: Emilio
authors.initials: E
authors.lastname: Hirsch
authors.forename: Guido
authors.initials: G
authors.lastname: Iaccarino
authors.forename: Karol A
authors.initials: KA
authors.lastname: Kaminski
authors.forename: Ralph
authors.initials: R
authors.lastname: Knöll
authors.forename: Manuel
authors.initials: M
authors.lastname: Mayr
authors.forename: Guido
authors.initials: G
authors.lastname: Tarone
authors.forename: Thomas
authors.initials: T
authors.lastname: Thum
authors.forename: Carlo G
authors.initials: CG
authors.lastname: Tocchetti
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D035843:Biomedical Research / Q000379:methods / Q000458:organization & administration; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology; D011379:Prognosis; D012107:Research Design; D018497:Ventricular Dysfunction, Right / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D016278:Ventricular Function, Right / Q000502:physiology
chemical_list: D015415:Biomarkers
keywords: Cardiac imaging; Chronic overload; Experimental myocardial preparations; Functional evaluation; Haemodynamics; Right ventricle function