title: Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects.
abstract: Irisin is assumed to be a relevant link between muscle and weight maintenance as well as to mediate exercise benefits on health. The aim of this study was to assess the possible associations between irisin levels and glucose homeostasis in obese subjects with metabolic syndrome (MetS) following an energy-restricted treatment. Ninety-six adults with excessive body weight and MetS features underwent a hypocaloric dietary pattern for 8 weeks, within the RESMENA randomized controlled trial (www.clinicaltrials.gov; NCT01087086). After the intervention, dietary restriction significantly reduced body weight and evidenced a dietary-induced decrease in circulating levels of irisin in parallel with improvements on glucose homeostasis markers. Interestingly, participants with higher irisin values at baseline (above the median) showed a greater reduction on glucose (P=0.022) and insulin (P=0.021) concentrations as well as on the homeostasis model assessment index (P=0.008) and triglycerides (P=0.006) after the dietary intervention, compared with those presenting low-irisin baseline values (below the median). Interestingly, a positive correlation between irisin and carbohydrate intake was found at the end of the experimental period. In conclusion, irisin appears to be involved in glucose metabolism regulation after a dietary-induced weight loss.
authors.affiliation: 1] Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain [2] Faculty of Health Science, Universidad Autonoma de Chile, Santiago, Chile.
authors.forename: P
authors.initials: P
authors.lastname: Lopez-Legarrea
authors.affiliation: Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain.
authors.forename: R
authors.initials: R
authors.lastname: de la Iglesia
authors.affiliation: 1] CIBERObn, Carlos III Health Institute, Madrid, Spain [2] Laboratory of Molecular and Cellular Endocrinology, Health Research Institute (IDIS), University of Santiago Hospital Complex (CHUS) and Santiago de Compostela University (USC), Santiago de Compostela, Spain [3] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
authors.forename: A B
authors.initials: AB
authors.lastname: Crujeiras
authors.affiliation: 1] CIBERObn, Carlos III Health Institute, Madrid, Spain [2] Laboratory of Molecular and Cellular Endocrinology, Health Research Institute (IDIS), University of Santiago Hospital Complex (CHUS) and Santiago de Compostela University (USC), Santiago de Compostela, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Pardo
authors.affiliation: Laboratory of Molecular and Cellular Endocrinology, Health Research Institute (IDIS), University of Santiago Hospital Complex (CHUS) and Santiago de Compostela University (USC), Santiago de Compostela, Spain.
authors.forename: F F
authors.initials: FF
authors.lastname: Casanueva
authors.affiliation: 1] Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain [2] CIBERObn, Carlos III Health Institute, Madrid, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Zulet
authors.affiliation: 1] Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain [2] CIBERObn, Carlos III Health Institute, Madrid, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Martinez