title: Preparative regimen dosing for hematopoietic stem cell transplantation in patients with chronic kidney disease: analysis of the literature and recommendations.
abstract: Hematopoietic stem cell transplantation (HSCT) is a potentially life-saving therapy that has traditionally been associated with high treatment-related mortality due to direct regimen toxicity and a high incidence of graft-versus-host disease. Historically, pre-existing renal insufficiency has been considered an exclusion criterion for transplantation. The advent of nonmyeloablative conditioning regimens as a less toxic modality for treatment has made HSCT more accessible to elderly patients and patients with comorbidities, such as renal impairment. However, there is no clear standard for how to dose preparative regimens for patients with chronic renal impairment who undergo HSCT. This article serves as a review of the current literature to provide dosing recommendations for commonly used preparative agents in the setting of chronic kidney disease, with the aim of providing optimal dosing for this patient population.
authors.affiliation: Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Megan N
authors.initials: MN
authors.lastname: Bodge
authors.affiliation: Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Veterans Affairs Medical Center, Nashville, Tennessee.
authors.forename: Srividya
authors.initials: S
authors.lastname: Reddy
authors.affiliation: Department of Pharmaceutical Services, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: Michael Scott
authors.initials: MS
authors.lastname: Thompson
authors.affiliation: Hematology and Stem Cell Transplantation Section, Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Veterans Affairs Medical Center, Nashville, Tennessee. Electronic address: Bipin.Savani@vanderbilt.edu.
authors.forename: Bipin N
authors.initials: BN
authors.lastname: Savani
mesh_terms: D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous
keywords: Dosing; Hematopoietic cell transplantation; Preparative regimens; Renal insufficiency