title: A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of Bravecto (fluralaner) against Frontline (fipronil) in flea- and tick-infested dogs.
abstract: BACKGROUND
  Fluralaner, a new molecular entity of the isoxazoline class, has potent insecticidal and acaricidal activity and can be safely administered orally to dogs.
  
  
  METHODS
  A randomized, investigator-blinded, multi-centered field study compared the flea- and tick-control efficacy for dogs over a 12-week period with either a single oral dose of Bravecto (fluralaner) formulated as a chewable tablet or with three sequential topical Frontline (fipronil) treatments. Individual dogs were the experimental unit for ticks and households were the experimental unit for fleas. A total of 108 tick-infested dogs were treated with Bravecto (fluralaner) and 54 tick-infested dogs were treated with Frontline (fipronil). Dogs in 115 flea-infested households received Bravecto (fluralaner) and dogs in 61 flea-infested households received Frontline (fipronil). Flea and tick counts were conducted on all dogs at weeks 2, 4, 8, and 12 following initial treatment and efficacy was calculated as the mean percent reduction in tick or flea count at each time point compared with the mean pretreatment initiation count for each treatment group. Additionally, the percentages of tick-free and flea-free households were determined.
  
  
  RESULTS
  At weeks 2, 4, 8, and 12, Bravecto (fluralaner) flea-control efficacy in treated households was 99.2%, 99.8%, 99.8%, and 99.9% respectively, while Frontline (fipronil) efficacy was 94.1%, 93.0%, 96.0%, and 97.3%, respectively. Bravecto (fluralaner) tick-control efficacy on treated dogs at weeks 2, 4, 8, and 12 was 99.9%, 99.9%, 99.7%, and 100%, respectively, and Frontline (fipronil) tick efficacy was 97.6%, 93.8%, 100%, and 100%, respectively. Of dogs showing clinical flea allergy dermatitis (FAD) signs at the study start, 85.7% in the Bravecto™ (fluralaner)-treated group and 55.6% in the Frontline (fipronil)-treated group were evaluated at each time point as showing no clinical signs of FAD until study completion.
  
  
  CONCLUSIONS
  Bravecto (fluralaner) administered once orally to dogs in a chewable tablet was highly effective for 12 weeks against fleas and ticks on privately-owned dogs and was significantly non-inferior (ticks) and superior (fleas) in comparison with topical Frontline (fipronil) administered 3 times sequentially.
authors.affiliation: MSD Animal Health Innovation GmbH, Zur Propstei, 55270 Schwabenheim, Germany. nadja.rohdich@msd.de.
authors.forename: Nadja
authors.initials: N
authors.lastname: Rohdich
authors.forename: Rainer K A
authors.initials: RK
authors.lastname: Roepke
authors.forename: Eva
authors.initials: E
authors.lastname: Zschiesche
mesh_terms: D056810:Acaricides / Q000494:pharmacology*; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D005260:Female; D058267:Flea Infestations / Q000188:drug therapy / Q000662:veterinary*; D005602:France; D005858:Germany; D007306:Insecticides / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology; D016037:Single-Blind Method; D005423:Siphonaptera / Q000187:drug effects; D013030:Spain; D013607:Tablets; D013984:Tick Infestations / Q000188:drug therapy / Q000662:veterinary*; D013987:Ticks / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: C000591860:A1443 compound; D056810:Acaricides; D007306:Insecticides; D007555:Isoxazoles; D011720:Pyrazoles; D013607:Tablets; C082360:fipronil