title: Related factors of dental caries and molar incisor hypomineralisation in a group of children with cystic fibrosis.
abstract: OBJECTIVE
  To investigate dental caries and molar incisor hypomineralisation (MIH)-related factors such as treatment, diet, brushing and salivary factors in children with cystic fibrosis (CF) compared with healthy peers.
  
  
  METHODS
  A cohort study was performed.
  
  
  METHODS
  This study was performed on 30 CF children comprising patients at the Faculty of Medicine and 30 control children recruited from the Dental School. Salivary factors, dental caries, MIH, daily diet, brushing habits were analysed. Statistical analysis was calculated by SPSS for Windows.
  
  
  RESULTS
  Decay missing filled teeth (DMF-T) score was 4.6 ± 4.0 in CF and 7.7 ± 2.7 in control (p = 0.001). 43% of CF children with MIH were found to use antibiotics, but no significant difference in the caries experience was found with antibiotic usage (p > 0.05). DMF-T of CF adolescents (23%) who use Tobramycin was 7 ± 3.5. DMF-T of CF children (20%) who take other antibiotics was 2.5 ± 3.5, but no statistical difference was found (p = 0.054). Saliva pH, salivary flow rate, and buffering capacity were not found statistically significant (p > 0.05).
  
  
  METHODS
  Percentage arithmetic mean value, standard deviation, independent sample t test, Fisher's exact test, Chi-square test and Mann-Whitney U test were used, while a p value of <0.05 was considered statistically significant.
  
  
  CONCLUSIONS
  Medication and diet could be considered as a risk factor for dental caries and factors such as salivary pH, good oral hygiene could play a protective role for oral health CF children. MIH frequency and lower caries experience seen in CF children could be due to salivary factors or pharmacological treatment they take. The multidisciplinary approach team would be advantageous in the management of children with CF and oral health should be under control during early years of life by paediatric dentists.
authors.affiliation: Department of Paediatric Dentistry, Dental School, Marmara University, Guzelbahce Buyukciftlik sok. No:6 Nisantasi, 34365, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Peker
authors.forename: S
authors.initials: S
authors.lastname: Mete
authors.forename: Y
authors.initials: Y
authors.lastname: Gokdemir
authors.forename: B
authors.initials: B
authors.lastname: Karadag
authors.forename: B
authors.initials: B
authors.lastname: Kargul
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002021:Buffers; D002648:Child; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000150:complications* / Q000188:drug therapy; D004245:DMF Index; D003731:Dental Caries / Q000150:complications*; D003744:Dental Enamel Hypoplasia / Q000150:complications*; D004032:Diet; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D009910:Oral Hygiene; D012463:Saliva / Q000737:chemistry / Q000502:physiology; D012636:Secretory Rate / Q000502:physiology; D014031:Tobramycin / Q000627:therapeutic use; D014099:Toothbrushing / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents; D002021:Buffers; D014031:Tobramycin