title: Adiponectin as a biomarker of osteoporosis in postmenopausal women: controversies.
abstract: The literature reports indicating a link between plasma levels of adiponectin and body fat, bone mineral density, sex hormones, and peri- and postmenopausal changes, draw attention to the possible use of adiponectin as an indicator of osteoporotic changes, suggesting that adiponectin may also modulate bone metabolism. In this study, we attempted to analyze the available in vitro and in vivo results which could verify this hypothesis. Although several studies have shown that adiponectin has an adverse effect on bone mass, mainly by intensifying resorption, this peptide has also been demonstrated to increase the proliferation and differentiation of osteoblasts, inhibit the activity of osteoclasts, and reduce bone resorption. There are still many ambiguities; for example, it can be assumed that concentrations of adiponectin in plasma do not satisfactorily reflect its production by adipose tissue, as well as conflicting in vitro and in vivo results. It seems that the potential benefit in the treatment of patients with osteoporosis associated with the pharmacological regulation of adiponectin is controversial.
authors.affiliation: Department of Functional Diagnostics and Physical Medicine, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, ul. Grudziądzka 31, 70-103 Szczecin, Poland ; Department of Physiology, Faculty of Natural Sciences, Szczecin University, ul. Felczaka 3c, 71-412 Szczecin, Poland.
authors.forename: Anna
authors.identifier: 0000-0002-5378-5409
authors.initials: A
authors.lastname: Lubkowska
authors.affiliation: Department of Functional Diagnostics and Physical Medicine, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, ul. Grudziądzka 31, 70-103 Szczecin, Poland.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Dobek
authors.affiliation: Institute of Physical Culture, Faculty of Physical Education, Health, and Tourism, Kazimierz Wielki University in Bydgoszcz, ul. Jana Karola Chodkiewicza 30, 85-064 Bydgoszcz, Poland.
authors.forename: Jan
authors.identifier: 0000-0001-6753-5139
authors.initials: J
authors.lastname: Mieszkowski
authors.affiliation: Department of Functional Diagnostics and Physical Medicine, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, ul. Grudziądzka 31, 70-103 Szczecin, Poland.
authors.forename: Wojciech
authors.initials: W
authors.lastname: Garczynski
authors.affiliation: Chair and Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, al. Powstańców Wlkp. 72, 70-111 Szczecin, Poland.
authors.forename: Dariusz
authors.initials: D
authors.lastname: Chlubek
mesh_terms: D052242:Adiponectin / Q000097:blood*; D052436:Adipose Tissue, White / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D010006:Osteoblasts / Q000502:physiology; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D012727:Sex Characteristics
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers