title: Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules.
abstract: Colloidal particles play an important role in various areas of material and pharmaceutical sciences, biotechnology, and biomedicine. In this overview we describe micro- and nano-particles used for the preparation of polyelectrolyte multilayer capsules and as drug delivery vehicles. An essential feature of polyelectrolyte multilayer capsule preparations is the ability to adsorb polymeric layers onto colloidal particles or templates followed by dissolution of these templates. The choice of the template is determined by various physico-chemical conditions: solvent needed for dissolution, porosity, aggregation tendency, as well as release of materials from capsules. Historically, the first templates were based on melamine formaldehyde, later evolving towards more elaborate materials such as silica and calcium carbonate. Their advantages and disadvantages are discussed here in comparison to non-particulate templates such as red blood cells. Further steps in this area include development of anisotropic particles, which themselves can serve as delivery carriers. We provide insights into application of particles as drug delivery carriers in comparison to microcapsules templated on them.
authors.affiliation: BIOtech Center, Department of Physics, University of Trento, via delle Regole 101, 38123 Mattarello, Italy; Shubnikov Institute of Crystallography, Russian Academy of Science, Leninskii prospekt 59, Moscow 119333, Russia.
authors.forename: Bogdan V
authors.initials: BV
authors.lastname: Parakhonskiy
authors.affiliation: Department of Interfaces, Max-Planck Institute of Colloids and Interfaces, Golm, Potsdam D-14476, Germany.
authors.forename: Alexey M
authors.initials: AM
authors.lastname: Yashchenok
authors.affiliation: Enzyme Biochemistry Laboratory, Max Planck Institute for Biophysical Chemistry, D-37077 Gottingen, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Konrad
authors.affiliation: Department of Interfaces, Max-Planck Institute of Colloids and Interfaces, Golm, Potsdam D-14476, Germany; Department of Molecular Biotechnology & Nano-Bio (NB)-Photonics, Ghent University, 9000 Ghent, Belgium. Electronic address: Andre.Skirtach@UGent.be.
authors.forename: Andre G
authors.initials: AG
authors.lastname: Skirtach
mesh_terms: D002214:Capsules; D003102:Colloids; D004339:Drug Compounding / Q000639:trends; D016503:Drug Delivery Systems; D008863:Microspheres; D008956:Models, Chemical; D053769:Nanocapsules / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000639:trends; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D002214:Capsules; D003102:Colloids; D053769:Nanocapsules; D011108:Polymers
keywords: Colloidal particles; Microcapsules; Multilayers; Polyelectrolytes; Templates