title: Dietary restriction in cerebral bioenergetics and redox state.
abstract: The brain has a central role in the regulation of energy stability of the organism. It is the organ with the highest energetic demands, the most susceptible to energy deficits, and is responsible for coordinating behavioral and physiological responses related to food foraging and intake. Dietary interventions have been shown to be a very effective means to extend lifespan and delay the appearance of age-related pathological conditions, notably those associated with brain functional decline. The present review focuses on the effects of these interventions on brain metabolism and cerebral redox state, and summarizes the current literature dealing with dietary interventions on brain pathology.
authors.affiliation: Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Amigo
authors.affiliation: Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, SP, Brazil.
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Kowaltowski
mesh_terms: D000375:Aging; D000544:Alzheimer Disease / Q000178:diet therapy; D000690:Amyotrophic Lateral Sclerosis / Q000178:diet therapy; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology; D001343:Autophagy; D001921:Brain / Q000378:metabolism*; D031204:Caloric Restriction; D019587:Dietary Supplements; D004734:Energy Metabolism; D004827:Epilepsy / Q000178:diet therapy; D005227:Fatty Acids / Q000378:metabolism; D005247:Feeding Behavior / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance; D008136:Longevity; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009714:Nucleus Accumbens / Q000502:physiology; D010084:Oxidation-Reduction; D010286:Paraventricular Hypothalamic Nucleus / Q000502:physiology; D010300:Parkinson Disease / Q000178:diet therapy; D015398:Signal Transduction; D056564:Sirtuin 1 / Q000502:physiology; D020521:Stroke / Q000178:diet therapy
chemical_list: D005227:Fatty Acids; C447939:SIRT1 protein, human; D056564:Sirtuin 1
keywords: AD, Alzheimer's disease; CR, caloric restriction; Caloric restriction; Energy metabolism; FR, food restriction; IF, intermittent fasting; KA, kainic acid; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Mitochondria; NOS, nitric oxide synthase; Neurological diseases; PD, Parkinson's disease; PTZ, pentylenetetrazole; ROS, reactive oxygen species; TCA, tricarboxylic acid cycle