title: A novel mechanism for cyclic adenosine monophosphate-mediated memory formation: Role of amyloid beta.
abstract: Cyclic adenosine monophosphate (cAMP) regulates long-term potentiation (LTP) and ameliorates memory in healthy and diseased brain. Increasing evidence shows that, under physiological conditions, low concentrations of amyloid β (Aβ) are necessary for LTP expression and memory formation. Here, we report that cAMP controls amyloid precursor protein (APP) translation and Aβ levels, and that the modulatory effects of cAMP on LTP occur through the stimulation of APP synthesis and Aβ production.
authors.affiliation: Department of Experimental Medicine, Section of General Pathology, University of Genoa, Genoa, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Ricciarelli
authors.forename: Daniela
authors.initials: D
authors.lastname: Puzzo
authors.forename: Olga
authors.initials: O
authors.lastname: Bruno
authors.forename: Elisa
authors.initials: E
authors.lastname: Canepa
authors.forename: Elena
authors.initials: E
authors.lastname: Gardella
authors.forename: Daniela
authors.initials: D
authors.lastname: Rivera
authors.forename: Lucia
authors.initials: L
authors.lastname: Privitera
authors.forename: Cinzia
authors.initials: C
authors.lastname: Domenicotti
authors.forename: Barbara
authors.initials: B
authors.lastname: Marengo
authors.forename: Umberto Maria
authors.initials: UM
authors.lastname: Marinari
authors.forename: Agostino
authors.initials: A
authors.lastname: Palmeri
authors.forename: Maria Adelaide
authors.initials: MA
authors.lastname: Pronzato
authors.forename: Ottavio
authors.initials: O
authors.lastname: Arancio
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fedele
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000172:deficiency / Q000235:genetics; D000818:Animals; D002478:Cells, Cultured; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism / Q000494:pharmacology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology; D006801:Humans; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects / Q000235:genetics; D008297:Male; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D004791:Enzyme Inhibitors; D005576:Colforsin; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases