title: Purple sweet potato (Ipomoea batatas L.) anthocyanins: preventive effect on acute and subacute alcoholic liver damage and dealcoholic effect.
abstract: This study aimed to investigate the dealcoholic effect and preventive effect of anthocyanins from purple sweet potato (PSPAs) on acute and subacute alcoholic liver damage (ALD). Seven-week-old male inbred mice were grouped into five groups: control group (without PSPAs and ethanol treatments), model group (with ethanol treatment only), low-dose group (50 mg PSPAs/kg body weight), middle-dose group (125 mg PSPAs/kg body weight), and high-dose group (375 mg PSPAs/kg body weight), and the mice in all groups were administered intragastrically. Biochemical parameters of serum and liver were determined, and the histopathological changes of liver tissue were also analyzed. Results showed that all tested parameters were ameliorated after consumption of PSPAs. Therefore, PSPAs have preventive effect on acute and subacute ALD. It is suggested that PSPAs could be used as a supplementary reagent during prophylactic and curative managements of ALD.
authors.affiliation: Laboratory of Food Chemistry and Nutrition Science, Institute of Agro-Products Processing Science and Technology, Chinese Academy of Agricultural Sciences; Key Laboratory of Agro-products Processing, Ministry of Agriculture, 2 Yuan Ming Yuan West Road, Haidian District, Beijing 100193, People's Republic of China.
authors.forename: Hongnan
authors.initials: H
authors.lastname: Sun
authors.forename: Taihua
authors.initials: T
authors.lastname: Mu
authors.forename: Xingli
authors.initials: X
authors.lastname: Liu
authors.forename: Miao
authors.initials: M
authors.lastname: Zhang
authors.forename: Jingwang
authors.initials: J
authors.lastname: Chen
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage*; D000431:Ethanol / Q000009:adverse effects; D006801:Humans; D027723:Ipomoea batatas / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage*
chemical_list: D000872:Anthocyanins; D010936:Plant Extracts; D000431:Ethanol