title: Recent studies of genetic dysfunction in pelvic organ prolapse: the role of collagen defects.
abstract: Gynaecologists are becoming increasingly aware that women with a family history of prolapse are at an increased risk of prolapse refractory to treatment. In the past five years, several genetic mutations have been shown to correlate with increased prolapse susceptibility. These mutations can result in disordered collagen metabolism, which weaken the fascial support of the pelvic organs. This review examines the contemporary evidence regarding the role of collagen in prolapse.
authors.affiliation: Pelvic Floor Unit, St George Hospital/University of New South Wales, Sydney, NSW, Australia.
authors.forename: Veronica F
authors.initials: VF
authors.lastname: Lim
authors.forename: John K
authors.initials: JK
authors.lastname: Khoo
authors.forename: Vivien
authors.initials: V
authors.lastname: Wong
authors.forename: Kate H
authors.initials: KH
authors.lastname: Moore
mesh_terms: D003094:Collagen / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D056887:Pelvic Organ Prolapse / Q000378:metabolism* / Q000473:pathology
chemical_list: D003094:Collagen; D020782:Matrix Metalloproteinases
keywords: collagen; genetic influences; immunohistochemistry; pelvic organ prolapse