title: Investigation of oxidative balance in patients with dysmenorrhea by multiple serum markers.
abstract: OBJECTIVE
  To investigate the level of oxidative stress in patients with dysmenorrhea by multiple serum markers including malondialdehyde (MDA), nitrotyrosine (3-NT), deoxyguanosine (8-OHdG) and superoxide dismutase (SOD).
  
  
  METHODS
  Fifty-eight women, aged between 20 and 34, who had had regular menses for at least six previous cycles, were involved. The women were divided into two groups. The study group consisted of 33 patients with primary dysmenorrhea, and the control group consisted of 25 healthy women.
  
  
  RESULTS
  Demographic characteristics of patients were similar between the two groups. The serum MDA levels were 1.32±0.46 and 0.91±0.26 nmol/mL for the dysmenorrhea and control groups, respectively (p<0.001). The differences in plasma levels of 3-NT, SOD and serum 8-OhdG were similar in both groups (p>0.05). Also, no correlation was found between the severity of dysmenorrhea and the levels of oxidative markers.
  
  
  CONCLUSIONS
  Oxidative stress is slightly aggravated in patients with dysmenorrhea.
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Fatih University, Ankara, Turkey.
authors.forename: Nilgün
authors.initials: N
authors.lastname: Turhan
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Fatih University, Ankara, Turkey.
authors.forename: Havva
authors.initials: H
authors.lastname: Celik
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Fatih University, Ankara, Turkey.
authors.forename: Candan İltemir
authors.initials: Cİ
authors.lastname: Duvan
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Fatih University, Ankara, Turkey.
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Onaran
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Aydın
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Fatih University, Ankara, Turkey.
authors.forename: Ferah
authors.initials: F
authors.lastname: Armutcu
keywords: Primary dysmenorrhea; deoxyguanosine; malondialdehyde; nitrotyrosine; superoxide dismutase