title: Development of a controlled release of salicylic acid loaded stearic acid-oleic acid nanoparticles in cream for topical delivery.
abstract: Lipid nanoparticles are colloidal carrier systems that have extensively been investigated for controlled drug delivery, cosmetic and pharmaceutical applications. In this work, a cost effective stearic acid-oleic acid nanoparticles (SONs) with high loading of salicylic acid, was prepared by melt emulsification method combined with ultrasonication technique. The physicochemical properties, thermal analysis and encapsulation efficiency of SONs were studied. TEM micrographs revealed that incorporation of oleic acid induces the formation of elongated spherical particles. This observation is in agreement with particle size analysis which also showed that the mean particle size of SONs varied with the amount of OA in the mixture but with no effect on their zeta potential values. Differential scanning calorimetry analysis showed that the SONs prepared in this method have lower crystallinity as compared to pure stearic acid. Different amount of oleic acid incorporated gave different degree of perturbation to the crystalline matrix of SONs and hence resulted in lower degrees of crystallinity, thereby improving their encapsulation efficiencies. The optimized SON was further incorporated in cream and its in vitro release study showed a gradual release for 24 hours, denoting the incorporation of salicylic acid in solid matrix of SON and prolonging the in vitro release.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: J O
authors.initials: JO
authors.lastname: Woo
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Misran
authors.affiliation: Mechatronics and BioMedical Engineering, Faculty of Engineering & Science, Universiti Tunku Abdul Rahman, Setapak, 53300 Kuala Lumpur, Malaysia.
authors.forename: P F
authors.initials: PF
authors.lastname: Lee
authors.affiliation: Prime Oleochemical Industries Sdn. Bhd., Taman Perindustrian Jaya, 47301 Petaling Jaya, Selangor, Malaysia.
authors.forename: L P
authors.initials: LP
authors.lastname: Tan
mesh_terms: D000287:Administration, Topical; D000890:Anti-Infective Agents / Q000737:chemistry*; D003692:Delayed-Action Preparations; D053758:Nanoparticles / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry*; D010316:Particle Size; D020156:Salicylic Acid / Q000737:chemistry*; D063465:Skin Cream / Q000737:chemistry*; D013229:Stearic Acids / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D013229:Stearic Acids; D019301:Oleic Acid; C031183:stearic acid; D020156:Salicylic Acid