title: Prediction of metabolic syndrome in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To identify biochemical factors that serve as predictors for the metabolic syndrome (MetS) in patients with polycystic ovary syndrome (PCOS) and to investigate the value of adipocytokines in the prediction of metabolic syndrome.
  
  
  METHODS
  A total of 91 pre-menopausal women with PCOS diagnosed according to the Rotterdam consensus criteria were recruited as study subjects. Waist circumference, blood pressure, body mass index (BMI), fasting glucose, serum lipids, insulin, FSH, LH, E2, total testosteron, homeostatic model assessment-insulin resistance (HOMA-IR), serum leptin and adiponectin levels were evaluated for all patients.
  
  
  RESULTS
  Of the 91 women with PCOS, 15 patients met the criteria for MetS. Body weight, BMI, waist circumference, systolic blood pressure, diastolic blood pressure, fasting glucose, total cholesterol, triglyceride, and VLDL concentrations were significantly higher and HDL was significantly lower in women with PCOS+MetS compared with those with PCOS only. However, the level of LDL, FSH, LH, E2 and total testesterone was not significantly different between these two groups. Women with PCOS+MetS had significantly higher levels of leptin and HOMA-IR, and significantly lower levels of adiponectin compared to the women with PCOS only. In the multiple logistic regression model, the association between HOMA-IR and leptin, and MetS remained statistically significant (p=0.001 and 0.018), while the association between adiponectin and MetS was no longer statistically significant.
  
  
  CONCLUSIONS
  Aside from the biochemical markers such as glucose, cholesterol and triglyceride, adipose tissue factors and insulin resistance are valuable parameters in the prediction of MetS in patients with PCOS.
authors.affiliation: Clinic of Gynecology and Obstetrics, Kanuni Sultan Süleyman Research and Teaching Hospital, Istanbul, Turkey.
authors.forename: Fırat
authors.initials: F
authors.lastname: Ersan
authors.affiliation: Clinic of Gynecology and Obstetrics, Kanuni Sultan Süleyman Research and Teaching Hospital, Istanbul, Turkey.
authors.forename: Esra
authors.initials: E
authors.lastname: Arslan
authors.affiliation: Department of Gynecology and Obstetrics, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.
authors.forename: Aytül Çorbacıoğlu
authors.initials: AÇ
authors.lastname: Esmer
authors.affiliation: Clinic of Gynecology and Obstetrics, Kanuni Sultan Süleyman Research and Teaching Hospital, Istanbul, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Aydın
authors.affiliation: Clinic of Biochemistry, Dr. Sadi Konuk Research and Teaching Hospital, Istanbul, Turkey.
authors.forename: Asuman
authors.initials: A
authors.lastname: Gedikbaşı
authors.affiliation: Clinic of Gynecology and Obstetrics, Kanuni Sultan Süleyman Research and Teaching Hospital, Istanbul, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Gedikbaşı
authors.affiliation: Clinic of Gynecology and Obstetrics, Kanuni Sultan Süleyman Research and Teaching Hospital, Istanbul, Turkey.
authors.forename: Ismet
authors.initials: I
authors.lastname: Alkış
authors.affiliation: Clinic of Gynecology and Obstetrics, Kanuni Sultan Süleyman Research and Teaching Hospital, Istanbul, Turkey.
authors.forename: Cemal
authors.initials: C
authors.lastname: Ark
keywords: HOMA-IR; Metabolic syndrome; adiponectin; leptin; polycystic ovary syndrome