title: [Association of IL-1β-511T gene rs16944 polymorphism with febrile seizures].
abstract: OBJECTIVE
  Despite substantial research efforts worldwide, the role of inflammatory cytokine IL-1β in the onset of febrile seizures (FS) remains controversial. The aim of this study was to assess the relationship between rs16944 polymorphism of the IL-1β-511T gene and occurrence of simple FS in a sample of Han children in northern China.
  
  
  METHODS
  The IL-1β-511T gene rs16944 was genotyped by SNaPshot SNP technique in 141 FS children and 130 healthy control subjects. The genotypic and allelic frequencies in the two groups were comparatively analyzed.
  
  
  RESULTS
  There were no significant differences in genotypic and allelic frequencies of rs16944 polymorphism of the IL-1β-511T gene between FS patients and control subjects (P>0.05).When the clinical data on A/A, A/G and G/G genotypes of the rs16944 polymorphism in FS patients, there was statistically significant difference in age of first onset (χ(2)=19.491, P<0.01), temperature of first onset (χ(2)=9.317, P<0.05) and family history of FS (χ(2)=26.798, P<0.01).
  
  
  CONCLUSIONS
  There is no association between rs16944 polymorphism of the IL-1β-511T gene and the incidence of FS in Han children in Northern China. However, the differences in genotypes of this polymorphism might be associated with pathogenesis and prognosis of simple FS in the population studied.
authors.affiliation: Neurology and Rehabilitation Center, Beijing Children's Hospital Affiliated to Capital University of Medical Sciences, Beijing 100045, China. rxt1997@126.com.
authors.forename: Xiao-Tun
authors.initials: XT
authors.lastname: Ren
authors.forename: Su-Zhen
authors.initials: SZ
authors.lastname: Sun
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Wang
mesh_terms: D002675:Child, Preschool; D002681:China / Q000208:ethnology; D005260:Female; D006801:Humans; D007223:Infant; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D003294:Seizures, Febrile / Q000235:genetics*
chemical_list: D053583:Interleukin-1beta