title: Oncogenic mutations produce similar phenotypes in Drosophila tissues of diverse origins.
abstract: An emerging interest in oncology is to tailor treatment to particular cancer genotypes, i.e. oncogenic mutations present in the tumor, and not the tissue of cancer incidence. Integral to such a practice is the idea that the same oncogenic mutation(s) produces similar outcomes in different tissues. To test this idea experimentally, we studied tumors driven by a combination of Ras(V12) and scrib(1) mutations in Drosophila larvae. We found that tumors induced in tissues of neural ectodermal and mesodermal origins behaved similarly in every manner examined: cell cycle checkpoints, apoptosis, cellular morphology, increased aneuploidy and response to Taxol. We conclude that oncogenic effects override tissue-specific differences, at least for the mutations, tissues, and phenotypes studied herein.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309-0347, USA.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Stickel
authors.forename: Tin Tin
authors.initials: TT
authors.lastname: Su
keywords: Aneuploidy; Cell cycle; Checkpoints; Drosophila; Ras; Tumor