title: The p38-PGC-1α-irisin-betatrophin axis: Exploring new pathways in insulin resistance.
abstract: The discovery of irisin as a novel and promising peptidic hormone has raised hopes regarding the hypothesis that irisin may provide additional benefits, not only for obesity and diabetes, but also for a wide range of pathological conditions since this hormone may prove to be therapeutically and clinically beneficial. In addition, a new hormone, betatrophin, has recently been identified by Yi and coworkers. Both hormones are connected by a new pathway clearly involved in insulin resistance. We hypothesize here how these hormones may be linked and their possible implications in both aged-reduced restricted regenerative capacity and dedifferentiated β cells of diabetic patients.
authors.affiliation: Department of Physiology; Faculty of Medicine; University of Valencia; Fundación Investigación Hospital Clínico Universitario/INCLIVA; Valencia, Spain.
authors.forename: Fabian
authors.initials: F
authors.lastname: Sanchis-Gomar
authors.affiliation: Department of Physiology; Faculty of Medicine; University of Valencia; Fundación Investigación Hospital Clínico Universitario/INCLIVA; Valencia, Spain.
authors.forename: Carme
authors.initials: C
authors.lastname: Perez-Quilis
keywords: diabetes; metabolism; obesity; oxidative stress; β cells