title: Sustained high levels of serum leptin rather than IL-6 observed in patients with postpartum thyroiditis during their first postpartum year.
abstract: The purpose of the study is to explore the roles of leptin and interleukin-6 (IL-6) during the first postpartum year in the occurrence and development of postpartum thyroiditis (PPT). We retrospectively collected serum samples from 57 PPT patients consisting of 34 overt PPT (O-PPT) and 23 subclinical PPT (S-PPT) in addition to 37 healthy postpartum women at four postpartum time points, i.e., 3-day and 3, 6, 12-month postpartum. Serum leptin and IL-6 levels were measured by radioimmunoassay and ELISA assay, respectively. Leptin level and leptin/BMI (LEP/BMI) ratio were higher in PPT patients than in control during the first postpartum year, but were not significantly different between O-PPT and S-PPT. However, a similar trend but did not reach significant difference in IL-6 level was observed during the postpartum period in PPT patients and control women. We conclude that a sustained high level of serum leptin after delivery may be involved in the pathogenesis of PPT. IL-6 does not contribute to the development of PPT.
authors.affiliation: Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University; Institute of Endocrinology, The Liaoning Provincial Key Laboratory of Endocrine Diseases, China Medical University, 155 Nanjing Bei Street, Liaoning, Shenyang, 110001, People's Republic of China.
authors.forename: Huiling
authors.initials: H
authors.lastname: Guo
authors.forename: Xiu
authors.initials: X
authors.lastname: Liu
authors.forename: Chenyang
authors.initials: C
authors.lastname: Li
authors.forename: Yushu
authors.initials: Y
authors.lastname: Li
authors.forename: Miao
authors.initials: M
authors.lastname: Sang
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Shan
authors.forename: Weiping
authors.initials: W
authors.lastname: Teng
authors.forename: Haixia
authors.initials: H
authors.lastname: Guan
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D020738:Leptin / Q000097:blood*; D049590:Postpartum Period / Q000097:blood*; D050032:Postpartum Thyroiditis / Q000097:blood*; D012189:Retrospective Studies
chemical_list: D015850:Interleukin-6; D020738:Leptin