title: The value of inflammatory parameters in the prognosis of malignant mesothelioma.
abstract: OBJECTIVE
  This study investigated the relationship between potential prognostic parameters that may be associated with increased inflammation and survival in patients with malignant mesothelioma (MM).
  
  
  METHODS
  This retrospective study assessed potential prognostic parameters measured at the time of MM diagnosis. Data on asbestos exposure, histopathological subtype of MM and laboratory parameters were collected.
  
  
  RESULTS
  In 155 patients with MM (90 male), mean survival time was 13.9 months. In univariate analysis, age ≥ 60 years and neutrophil-to-lymphocyte ratio (NLR) ≥ 3 were associated with significantly shortened median survival times. In multivariate analysis, nonepithelial subtype, red cell distribution width (RDW) ≥ 20% and NLR ≥ 3 were associated with significantly shortened median survival times. Mortality rate was increased 2.77-, 1.67- and 1.52-fold in patients with RDW ≥ 20%, NLR ≥ 3 and nonepithelial subtype, respectively. Nonepithelial subtype, white blood cell count ≥ 11 200 µl and platelet-to-lymphocyte ratio ≥ 300 at baseline were associated with a heightened NLR value.
  
  
  CONCLUSIONS
  The NLR and RDW were significant predictive factors for MM prognosis.
authors.affiliation: Department of Chest Diseases, Dicle University, Diyarbakir, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Abakay
authors.forename: Abdullah Cetin
authors.initials: AC
authors.lastname: Tanrikulu
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Palanci
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Abakay
mesh_terms: D001194:Asbestos / Q000009:adverse effects*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology* / Q000401:mortality*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008654:Mesothelioma / Q000276:immunology* / Q000401:mortality*; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D001194:Asbestos
keywords: Malignant mesothelioma; neutrophil-to-lymphocyte ratio; prognosis; red cell distribution width