title: In vitro biological activity of decoction of Joshanda.
abstract: Joshanda is a polyherbal product, commonly practicing in inflammation of upper respiratory tract as tea. The present study was conducted to find out its antimicrobial, phytotoxic, leishmanicidal and cytotoxic activities. The decoction of the product showed profound activity against Gram positive tested pathogens especially S. aureus 36.5 mm zone of inhibition at 8.0 μg/ml. However, it was inactive against C. albicans. Closed correlation was observed between two methods in terms of results. It had potent phytotoxic activity (75%). However, it was devoid of any activity leishmanicidal and cytotoxic activity. Phytochemical studies of Joshanda showed the presence of various pharmacologically active groups.
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.lastname: Abdullah
authors.affiliation: Medicinal Botanical Centre, PCSIR labs Complex Peshawar, Peshawar, Pakistan.
authors.forename: Humaira
authors.initials: H
authors.lastname: Inayat
authors.affiliation: Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan.
authors.forename: Haroon
authors.initials: H
authors.lastname: Khan
authors.affiliation: Medicinal Botanical Centre, PCSIR labs Complex Peshawar, Peshawar, Pakistan.
authors.forename: Lajber
authors.initials: L
authors.lastname: Khan
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Mohammad Iqbal
authors.initials: MI
authors.lastname: Khan
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
authors.forename: Sohail
authors.initials: S
authors.lastname: Hassan
authors.affiliation: Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
authors.forename: Murad Ali
authors.initials: MA
authors.lastname: Khan
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents; D000935:Antifungal Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D001156:Artemia; D004354:Drug Screening Assays, Antitumor; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006540:Herbicides; D006801:Humans; D007891:Leishmania / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010269:Paraquat / Q000633:toxicity; D028321:Plant Preparations / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D000981:Antiprotozoal Agents; D006540:Herbicides; C588255:Joshanda; D028321:Plant Preparations; D010269:Paraquat