title: Follistatin-like 5 is expressed in restricted areas of the adult mouse brain: Implications for its function in the olfactory system.
abstract: Follistatin-like 5 (Fstl5), a member of the follistatin family of genes, encodes a secretory glycoprotein. Previous studies revealed that other members of this family including Fstl1 and Fstl3 play an essential role in development, homeostasis, and congenital disorders. However, the in vivo function of Fstl5 is poorly understood. To gain insight into the function of Fstl5 in the mouse central nervous system, we examined the Fstl5 expression pattern in the adult mouse brain. The results of in situ hybridization analysis showed a highly restricted pattern of Fstl5, namely, with localization in the olfactory system, hippocampal CA3 area and granular cell layer of the cerebellum. Restricted expression in the olfactory system suggests a possible role for Fstl5 in maintaining odor perception.
authors.affiliation: Department of Histology and Neurobiology, Dokkyo Medical University School of Medicine, Tochigi, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Masuda
authors.forename: Chie
authors.initials: C
authors.lastname: Sakuma
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nagaoka
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamagishi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Ueda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nagase
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yaginuma
mesh_terms: D000818:Animals; D038681:Follistatin / Q000096:biosynthesis / Q000235:genetics*; D038702:Follistatin-Related Proteins / Q000096:biosynthesis* / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D009812:Odorants; D009833:Olfactory Pathways; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: C569961:FSTL5 protein, human; D038681:Follistatin; D038702:Follistatin-Related Proteins; D012333:RNA, Messenger; C000592537:follistatin-related protein 5, mouse
keywords: KIAA clones; central nervous system; coronal section; follistatin; mouse