title: Exploitation of host lipids by bacteria.
abstract: Bacteria that interact with eukaryotic cells have developed a variety of strategies to divert host lipids, or cellular processes driven by lipids, to their benefit. Host lipids serve as building blocks for bacterial membrane formation and as energy source. They promote the formation of specific microdomains, facilitating interactions with the host. Host lipids are also critical players in the entry of bacteria or toxins into cells, and, for bacteria growing inside parasitophorous vacuoles, in building a secure shelter. Bacterial dissemination is often dependent on enzymatic activities targeting host lipids. Finally, on a larger scale, long lasting parasitic association can disturb host lipid metabolism so deeply as to 'reprogram' it, as proposed in the case of Mycobacterium infection.
authors.affiliation: Institut Pasteur, Unité de Biologie des Interactions Cellulaires, Paris, France; CNRS URA 2582, Paris, France; Université Pierre et Marie Curie, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Vromman
authors.affiliation: Institut Pasteur, Unité de Biologie des Interactions Cellulaires, Paris, France; CNRS URA 2582, Paris, France. Electronic address: asubtil@pasteur.fr.
authors.forename: Agathe
authors.initials: A
authors.lastname: Subtil
mesh_terms: D000818:Animals; D001419:Bacteria; D002462:Cell Membrane; D054884:Host-Pathogen Interactions; D006801:Humans; D008055:Lipids; D051379:Mice
chemical_list: D008055:Lipids