title: Strategies to prepare TiO2 thin films, doped with transition metal ions, that exhibit specific physicochemical properties to support osteoblast cell adhesion and proliferation.
abstract: Metal ion doped titanium oxide (TiO2) thin films, as bioactive coatings on metal or other implantable materials, can be used as surfaces for studying the cell biological properties of osteogenic and other cell types. Bulk crystallite phase distribution and surface carbon-oxygen constitution of thin films, play an important role in determining the biological responses of cells that come in their contact. Here we present a strategy to control the polarity of atomic interactions between the dopant metal and TiO2 molecules and obtain surfaces with smaller crystallite phases and optimal surface carbon-oxygen composition to support the maximum proliferation and adhesion of osteoblast cells. Our results suggest that surfaces, in which atomic interactions between the dopant metals and TiO2 were less polar, could support better adhesion, spreading and proliferation of cells.
authors.affiliation: CSIR-Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India. Electronic address: marshal@ccmb.res.in.
authors.forename: Marshal
authors.initials: M
authors.lastname: Dhayal
authors.affiliation: CSIR-Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India.
authors.forename: Renu
authors.initials: R
authors.lastname: Kapoor
authors.affiliation: CSIR-Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India.
authors.forename: Pavana Goury
authors.initials: PG
authors.lastname: Sistla
authors.affiliation: CSIR-National Physical Laboratory, Dr K S Krishnan Marg, New Delhi, India.
authors.forename: Ravi Ranjan
authors.initials: RR
authors.lastname: Pandey
authors.affiliation: CSIR-Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India.
authors.forename: Satabisha
authors.initials: S
authors.lastname: Kar
authors.affiliation: CSIR-National Physical Laboratory, Dr K S Krishnan Marg, New Delhi, India.
authors.forename: Krishan Kumar
authors.initials: KK
authors.lastname: Saini
authors.affiliation: CSIR-Center for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India. Electronic address: gpande@ccmb.res.in.
authors.forename: Gopal
authors.initials: G
authors.lastname: Pande
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D007477:Ions / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D051379:Mice; D010006:Osteoblasts / Q000166:cytology; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry* / Q000633:toxicity
chemical_list: D007477:Ions; D008670:Metals; C009495:titanium dioxide; D014025:Titanium
keywords: Atomic radius; Biomaterials; Electronegativity; Osteoinduction; Surface energy