title: Preventable coronary heart disease events from control of cardiovascular risk factors in US adults with diabetes (projections from utilizing the UKPDS risk engine).
abstract: Type 2 diabetes mellitus (T2DM) carries significant risks for coronary heart disease (CHD). We examined the potential US population impact of single and composite risk factor control. Among US adults with diagnosed T2DM aged≥30 years in the National Health and Nutrition Examination Survey 2007 to 2012, we assessed CHD events preventable using the United Kingdom Prospective Diabetes Study CHD risk engine. We examined in all those not at goal the impact of statistical control of smoking, glycated hemoglobin, systolic blood pressure, and total and high-density lipoprotein cholesterol, according to the predefined criteria setting risk factors at different levels of control representing (1) "All to Goal," (2) at "Nominal Control," or (3) at "Aggressive Control." Preventable CHD events represented the difference between the number of events estimated from the control of these risk factors versus current levels of the risk factors. Of 606 men (representing 6.2 million) and 603 women (6.3 million) with DM and no previous CHD, 1.3 million men and 0.7 million women would develop a CHD event within 10 years if left uncontrolled. Controlling all risk factors to goal was projected to prevent 35% and 45% of CHD events in men and women, respectively. Nominal risk factor control was projected to prevent 36% and 38% and aggressive control 51% and 61% of CHD events, respectively. In conclusion, a significant proportion of CHD events in adults with T2DM could be prevented from composite control of risk factors often not at goal.
authors.affiliation: Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, California. Electronic address: ndwong@uci.edu.
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Wong
authors.affiliation: Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, California.
authors.forename: Christopher
authors.initials: C
authors.lastname: Patao
authors.affiliation: Heart Disease Prevention Program, Division of Cardiology, University of California, Irvine, California.
authors.forename: Shaista
authors.initials: S
authors.lastname: Malik
authors.affiliation: Global Health Outcomes Research, Bristol Myers-Squibb, Princeton, New Jersey.
authors.forename: Uchenna
authors.initials: U
authors.lastname: Iloeje
mesh_terms: D000328:Adult; D003327:Coronary Disease / Q000150:complications / Q000453:epidemiology / Q000517:prevention & control*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009749:Nutrition Surveys / Q000379:methods*; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D015996:Survival Rate / Q000639:trends; D014481:United States / Q000453:epidemiology