title: Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.
abstract: Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search for therapies that have the potential to offer greater efficacy and tolerability compared with current treatments.
authors.affiliation: Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, United Kingdom; and.
authors.forename: Oliver
authors.initials: O
authors.lastname: Lomas
authors.forename: Manuela
authors.initials: M
authors.lastname: Zaccolo
mesh_terms: D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D006801:Humans; D009712:Nucleotides, Cyclic / Q000378:metabolism*; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D009712:Nucleotides, Cyclic; D017868:Cyclic AMP-Dependent Protein Kinases; D010727:Phosphoric Diester Hydrolases