title: Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population.
abstract: BACKGROUND
  Accumulating evidences indicate that circadian abnormalities lead to sleep disorder, neurodegenerative diseases and depression. We have reported that the polymorphisms of a clock-related gene, Tef, contributed to the risk of sleep disturbances and depression in the Parkinson disease. The objective of the present study was to examine whether the three clock genes we previously studied are associated with major depressive disorder (MDD) in the Chinese population.
  
  
  METHODS
  105 Subjects with MDD and 485 control subjects participated in this case-control study. Demographics, Mini-mental Status Examination (MMSE), and the Hamilton rating scale for depression (HAMD) were obtained in all subjects. Genotypes of single nucleotide polymorphisms (SNPs) of Cry1 rs2287161, Cry2 rs10838524 and Tef rs738499 were screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  MDD cases had a significantly higher frequency carrying the C allele and CC genotype in Cry1 rs2287161 and the T allele and TT genotype in Tef rs738499 than controls.
  
  
  CONCLUSIONS
  The sample size of MDD group was relatively small.
  
  
  CONCLUSIONS
  The polymorphisms of Cry1 rs2287161 and Tef rs738499 are associated to MDD.
authors.affiliation: Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
authors.forename: Ping
authors.initials: P
authors.lastname: Hua
authors.affiliation: Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China. Electronic address: liuweiguo1111@sina.com.
authors.forename: Weiguo
authors.initials: W
authors.lastname: Liu
authors.affiliation: Department of Neurology, University of Washington, School of Medicine, Washington, 98195, United States.
authors.forename: Donghui
authors.initials: D
authors.lastname: Chen
authors.affiliation: Department of Neurology, BenQ Medical Center Affiliated to Nanjing Medical University, Nanjing 210029, P.R. China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Medical Psychology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.affiliation: Medical Psychology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.affiliation: Medical Psychology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
authors.forename: Chun
authors.initials: C
authors.lastname: Wang
authors.affiliation: Medical Psychology, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
authors.forename: Suwan
authors.initials: S
authors.lastname: Guo
authors.affiliation: Clinical Laboratory, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.affiliation: Institute of Scientific Research, Affiliated Brain Hospital of Nanjing Medical University, Nanjing 210029, P.R. China.
authors.forename: Hong
authors.initials: H
authors.lastname: Xiao
authors.affiliation: Department of Neurology, The Neurological Institute of New York, Columbia University Medical Center, NY 10032, United States. Electronic address: sk3295@columbia.edu.
authors.forename: Sheng-Han
authors.initials: SH
authors.lastname: Kuo
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D050976:Basic-Leucine Zipper Transcription Factors / Q000235:genetics*; D056926:CLOCK Proteins / Q000235:genetics; D016022:Case-Control Studies; D056931:Cryptochromes / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide
chemical_list: D050976:Basic-Leucine Zipper Transcription Factors; C538963:CRY1 protein, human; C538966:CRY2 protein, human; D056931:Cryptochromes; C489490:TEF protein, human; D056926:CLOCK Proteins
keywords: Circadian rhythm; Clock genes; Cry1; Major depressive disorder; Tef