title: Combined approach in ventricular septal defect and adult pulmonary hypertension.
abstract: Early closure of a large ventricular septal defect before the onset of elevated pulmonary vascular resistance is important. Pulmonary hypertensive events might cause significant morbidity or mortality, even when closure is performed after infancy. Therefore, treatment of pulmonary hypertension after surgery may be the most important issue affecting the prognosis. We describe successful treatment of pulmonary hypertension in a 25-year-old woman after closure of large ventricular septal defect, with inhaled nitric oxide, sildenafil, and bosentan.
authors.affiliation: Department of Cardiovascular Surgery, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Faruk
authors.initials: F
authors.lastname: Cingoz
authors.forename: Murat
authors.initials: M
authors.lastname: Tavlasoglu
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Sahin
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kurkluoglu
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D000077300:Bosentan; D006348:Cardiac Surgical Procedures; D004359:Drug Therapy, Combination; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D009569:Nitric Oxide / Q000008:administration & dosage; D010879:Piperazines / Q000008:administration & dosage; D011687:Purines / Q000008:administration & dosage; D000068677:Sildenafil Citrate; D013449:Sulfonamides / Q000008:administration & dosage; D013450:Sulfones / Q000008:administration & dosage; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; D011687:Purines; D013449:Sulfonamides; D013450:Sulfones; D014665:Vasodilator Agents; D009569:Nitric Oxide; D000068677:Sildenafil Citrate; D000077300:Bosentan
keywords: Antihypertensive agents; heart septal defects; hypertension; pulmonary; vasodilator agents; ventricular