title: Methemoglobinemia due to nitric oxide therapy in a child after cardiac surgery.
abstract: A 5-month-old boy with trisomy 21 had repair of ventricular septal defect, atrial septal defect, and ligation of a patent ductus arteriosus. Due to severe pulmonary hypertension, NO inhalation was instituted postoperatively. Over the course of next few hours, he developed life-threatening methemoglobinemia. The condition once recognized was corrected with exchange blood transfusion. The management strategy is described with a brief review of the literature.
authors.affiliation: Department of Cardiac Services, North West Armed Forces Hospital, Tabuk, Saudi Arabia.
authors.forename: Aitizaz Uddin
authors.initials: AU
authors.lastname: Syed
authors.forename: Ali E Ali
authors.initials: AE
authors.lastname: Jelly
authors.forename: Ahmed Azmy
authors.initials: AA
authors.lastname: Algebaly
authors.forename: Mustafa M
authors.initials: MM
authors.lastname: Altoonisi
authors.forename: Ahmed El
authors.initials: AE
authors.lastname: Shatoory
mesh_terms: D000015:Abnormalities, Multiple; D000280:Administration, Inhalation; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures; D065627:Familial Primary Pulmonary Hypertension; D006330:Heart Defects, Congenital / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D007223:Infant; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D009569:Nitric Oxide / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D009569:Nitric Oxide
keywords: Heart defects; congenital; infant; methemoglobinemia; nitric oxide