title: Cholinergic modulation of event-related oscillations (ERO).
abstract: The cholinergic system in the brain modulates patterns of activity involved in general arousal, attention processing, memory and consciousness. In the present study we determined the effects of selective cholinergic lesions of the medial septum area (MS) or nucleus basalis magnocellularis (NBM) on amplitude and phase characteristics of event related oscillations (EROs). A time-frequency based representation was used to determine ERO energy, phase synchronization across trials, recorded within a structure (phase lock index, PLI), and phase synchronization across trials, recorded between brain structures (phase difference lock index, PDLI), in the frontal cortex (Fctx), dorsal hippocampus (DHPC) and central amygdala (Amyg). Lesions in MS produced: (1) decreases in ERO energy in delta, theta, alpha, beta and gamma frequencies in Amyg, (2) reductions in gamma ERO energy and PLI in Fctx, (3) decreases in PDLI between the Fctx-Amyg in the theta, alpha, beta and gamma frequencies, and (4) decreases in PDLI between the DHPC-Amyg and Fctx-DHPC in the theta frequency bands. Lesions in NBM resulted in: (1) increased ERO energy in delta and theta frequency bands in Fctx, (2) reduced gamma ERO energy in Fctx and Amyg, (3) reductions in PLI in the theta, beta and gamma frequency ranges in Fctx, (4) reductions in gamma PLI in DHPC and (5) reduced beta PLI in Amyg. These studies suggest that the MS cholinergic system can alter phase synchronization between brain areas whereas the NBM cholinergic system modifies phase synchronization/phase resetting within a brain area.
authors.affiliation: Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-1501, La Jolla, CA 92037, USA.
authors.forename: Manuel
authors.initials: M
authors.lastname: Sanchez-Alavez
authors.affiliation: Laboratory of Neuropharmacology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Plaça de la Mercè, 10-12, 08002 Barcelona, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Robledo
authors.affiliation: Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-1501, La Jolla, CA 92037, USA.
authors.forename: Derek N
authors.initials: DN
authors.lastname: Wills
authors.affiliation: Laboratory of Neuropharmacology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Plaça de la Mercè, 10-12, 08002 Barcelona, Spain.
authors.forename: James
authors.initials: J
authors.lastname: Havstad
authors.affiliation: Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-1501, La Jolla, CA 92037, USA. Electronic address: cindye@scripps.edu.
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Ehlers
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000161:Acoustic Stimulation; D000679:Amygdala / Q000502:physiology; D000818:Animals; D001307:Auditory Perception / Q000502:physiology; D020532:Basal Nucleus of Meynert / Q000502:physiology* / Q000503:physiopathology; D001921:Brain / Q000502:physiology*; D058256:Brain Waves / Q000502:physiology*; D059329:Cholinergic Neurons / Q000502:physiology; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D009434:Neural Pathways; D051381:Rats; D012686:Septal Nuclei / Q000502:physiology* / Q000503:physiopathology
chemical_list: D000109:Acetylcholine
keywords: Cholinergic system; Electroencephalogram; Event related oscillation; Event-related potential; Phase difference lock index; Phase lock index