title: PrediQt-Cx: post treatment health related quality of life prediction model for cervical cancer patients.
abstract: BACKGROUND
  Cervical cancer is the third largest cause of cancer mortality in India. The objectives of the study were to compare the pre and the post treatment quality of life in cervical cancer patients and to develop a prediction model to provide an insight into the possibilities in the treatment modules.
  
  
  RESULTS
  A total of 198 patients were assessed with two structured questionnaires of Health Related Quality of Life (The European Organisation for Research and Treatment of Cancer, EORTC QLQ C-30 and CX-24). The baseline observations were recorded when the patients first reported (T1) and second evaluation was done at 6 months post treatment (T2). The mean age of detection was 50.9 years with the literacy level being non-educated or less than high school. Majority of them were married/cohabiting 179 (90.4%). On histopathological examination (HPE) squamous cell carcinoma was found to be the most common cell type carcinoma 147 (74.2%) followed by Adenocarcinoma 31 (15.7%). Radical hysterectomy was the most common treatment modality 76 (38.4%), followed by Wertheims Hysterectomy 46 (23.2%) and Radiochemotherapy 59 (29.8%). The mean score of global health of cervical cancer patients post treatment was 77.90, which was significantly higher than the pre - treatment score (54.32). Mean "symptoms score" post treatment was 21.69 with an aggravation of 7.32 compared to pre treatment scores. Patients experienced substantial decrease in sexual activity post treatment.
  
  
  CONCLUSIONS
  The prediction model(PrediQt-Cx), based on Support Vector Machine(SVM) for predicting post treatment HRQoL in cervical cancer patients was developed and internally cross validated. After external validation PrediQt-Cx can be easily employed to support decision making by clinicians and patients from north India region, through openly made available for access at http://prediqt.org.
authors.affiliation: Institute of Bioinformatics, Bangalore, Karnataka, India ; Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Satwant
authors.initials: S
authors.lastname: Kumar
authors.affiliation: Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India ; Himalayan Institute of Medical Sciences(HIMS), Dehradun, Uttarkhand, India.
authors.forename: Madhu Lata
authors.initials: ML
authors.lastname: Rana
authors.affiliation: Rabindra Nath Tagore Medical College, Udaipur, Rajasthan, India.
authors.forename: Khushboo
authors.initials: K
authors.lastname: Verma
authors.affiliation: Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India ; Himalayan Institute of Medical Sciences(HIMS), Dehradun, Uttarkhand, India.
authors.forename: Narayanjeet
authors.initials: N
authors.lastname: Singh
authors.affiliation: Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Sharma
authors.affiliation: Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Maria
authors.affiliation: Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Gobind Singh
authors.initials: GS
authors.lastname: Dhaliwal
authors.affiliation: Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
authors.forename: Harkiran Kaur
authors.initials: HK
authors.lastname: Khaira
authors.affiliation: Himalayan Institute of Medical Sciences(HIMS), Dehradun, Uttarkhand, India.
authors.forename: Sunil
authors.initials: S
authors.lastname: Saini
mesh_terms: D005260:Female; D006801:Humans; D007194:India; D016015:Logistic Models; D008875:Middle Aged; D008960:Models, Psychological; D011594:Psychometrics / Q000379:methods*; D011788:Quality of Life / Q000523:psychology*; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D002583:Uterine Cervical Neoplasms / Q000523:psychology* / Q000628:therapy