title: Association of megsin 2093C/T, 2180C/T and C25663G gene polymorphism with the risk of IgA nephropathy.
abstract: The association between megsin 2093C/T, 2180C/T and C25663G gene polymorphisms and IgA nephropathy (IgAN) risk remains unclear. We aimed to evaluate the association between megsin 2093C/T, 2180C/T and C25663G gene polymorphisms and IgAN risk by performing a meta-analysis. Eligible studies were searched according to predefined criteria by using electronic databases. Six articles were identified for the analysis of the association between megsin 2093C/T, 2180C/T and C25663G gene polymorphisms and IgAN risk. 2093C/T C allele was associated with IgAN risk in overall populations and Asians (overall populations: p = 0.014, Asians: p = 0.037). 2093C/T CC/TT genotype was not associated with IgAN risk in overall populations, Caucasians and Asians. 2180C/T C allele was correlated with IgAN risk in Caucasians (p = 0.024). 2180C/T CC/TT genotype was not associated with IgAN risk in overall populations, Caucasians and Asians. C25663G gene polymorphism was not associated with IgAN onset in Asians. In conclusion, megsin 2093C/T C allele may be genetic marker for IgAN susceptibility in overall populations and Asians. 2180C/T C allele may be risk factor for IgAN onset in Caucasians. However, more studies should be performed in the future.
authors.affiliation: Department of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing Medical University , Nanjing , China and.
authors.forename: Song
authors.initials: S
authors.lastname: Mao
authors.forename: Xianguo
authors.initials: X
authors.lastname: Ren
authors.forename: Songming
authors.initials: S
authors.lastname: Huang
authors.forename: Aihua
authors.initials: A
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D015843:Serpins / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C114170:SERPINB7 protein, human; D015843:Serpins
keywords: 2093C/T; 2180C/T; C25663G; IgA nephropathy; gene polymorphisms; meta-analysis