title: [Molecular mechanisms of dormancy and drug tolerance in mycobacteria].
abstract: Instead of rapid multiplication, pathogenic mycobacteria, such as Mycobacterium tuberculosis are likely to have acquired slow but long life. Host immunity affords desirable non-competitive environment for M tuberculosis in human lungs, where this pathogen slowly grows or arrests growing, which avoids rapid loss of living places. Mycobacterial DNA-binding protein 1 (MDP1), a unique histone-like protein associating mycobacterial GC-rich DNA, has pivotal role in realizing such slow life and pathogenesis including drug tolerance to isoniazid.
authors.affiliation: Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Japan. sohkichi@med.niigata-u.ac.jp
authors.forename: Sohkichi
authors.initials: S
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D018407:Bacterial Physiological Phenomena / Q000235:genetics*; D001426:Bacterial Proteins / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology*; D008168:Lung / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development* / Q000472:pathogenicity
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C403010:MDP1 protein, Mycobacterium; D007538:Isoniazid