title: Predictors for improvement of problem-solving during cognitive remediation for patients with Schizophrenia.
abstract: Cognitive remediation is a promising pathway for ameliorating cognitive impairment of patients with schizophrenia. Here, we investigate predictors of improvement in problem-solving ability for two different types of cognitive remediation - specific problem-solving training and training of basic cognition. For this purpose we conducted a re-analysis of a randomized controlled trial comparing these two training approaches. The main outcome measure was improvement in problem-solving performance. Correlational analyses were used to assess the contribution of clinical, cognitive and training-related predictors. In the problem-solving training group, impaired pre-training planning ability was associated with stronger improvement. In contrast, in the basic cognition training group antipsychotic medication dose emerged as a negative predictor. These results demonstrate that predictors for successful cognitive remediation depend on the specific intervention. Furthermore, our results suggest that at least in the planning domain patients with impaired performance benefit particularly from a specific intervention.
authors.affiliation: 1 Section of Experimental Psychopathology and Neurophysiology, Department of General Adult Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.
authors.forename: Katlehn
authors.initials: K
authors.lastname: Rodewald
authors.affiliation: 2 Department of Psychology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Daniel V
authors.initials: DV
authors.lastname: Holt
authors.affiliation: 1 Section of Experimental Psychopathology and Neurophysiology, Department of General Adult Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.
authors.forename: Mirjam
authors.initials: M
authors.lastname: Rentrop
authors.affiliation: 1 Section of Experimental Psychopathology and Neurophysiology, Department of General Adult Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Roesch-Ely
authors.affiliation: 3 Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
authors.forename: Michael
authors.initials: M
authors.lastname: Liebrenz
authors.affiliation: 2 Department of Psychology, University of Heidelberg, Heidelberg, Germany.
authors.forename: Joachim
authors.initials: J
authors.lastname: Funke
authors.affiliation: 1 Section of Experimental Psychopathology and Neurophysiology, Department of General Adult Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Weisbrod
authors.affiliation: 3 Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
authors.forename: Stefan
authors.initials: S
authors.lastname: Kaiser
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D002746:Chlorpromazine / Q000627:therapeutic use; D003072:Cognition Disorders / Q000209:etiology* / Q000534:rehabilitation*; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011340:Problem Solving / Q000187:drug effects / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D002746:Chlorpromazine