title: Eosinophilic esophagitis.
abstract: OBJECTIVE
  To review the understanding of the pathogenesis of eosinophilic esophagitis (EoE) and the role of the immune system in the disease process.
  
  
  METHODS
  Peer-reviewed articles on EoE from PubMed searching for "Eosinophilic Esophagitis and fibrosis" in the period of 1995 to 2013.
  
  
  METHODS
  Studies on the clinical and immunologic features, pathogenesis, and management of EoE.
  
  
  RESULTS
  Recent work has revealed that thymic stromal lymphopoietin and basophil have an increased role in the pathogenesis of disease. Additional understanding on the role of fibrosis in EoE is emerging.
  
  
  CONCLUSIONS
  The incidence of EoE is increasing like most atopic disease. Similar to other allergic diseases, EoE is treated with topical steroids and/or allergen avoidance.
authors.affiliation: Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
authors.forename: Jamie
authors.initials: J
authors.lastname: Merves
authors.affiliation: Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
authors.forename: Amanda
authors.initials: A
authors.lastname: Muir
authors.affiliation: Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
authors.forename: Prasanna
authors.initials: P
authors.lastname: Modayur Chandramouleeswaran
authors.affiliation: Division of Allergy and Immunology, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
authors.forename: Antonella
authors.initials: A
authors.lastname: Cianferoni
authors.affiliation: Division of Gastroenterology and Nutrition, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia.
authors.forename: Mei-Lun
authors.initials: ML
authors.lastname: Wang
authors.affiliation: Division of Allergy and Immunology, The Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia. Electronic address: spergel@email.chop.edu.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Spergel
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000485:Allergens / Q000276:immunology; D001491:Basophils / Q000276:immunology; D002648:Child; D016207:Cytokines / Q000378:metabolism; D057765:Eosinophilic Esophagitis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D004804:Eosinophils / Q000166:cytology; D004947:Esophagus / Q000276:immunology* / Q000473:pathology*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D000094632:Thymic Stromal Lymphopoietin
chemical_list: D000305:Adrenal Cortex Hormones; D000485:Allergens; D016207:Cytokines; D000094632:Thymic Stromal Lymphopoietin