title: An analysis of cerebral blood flow from middle cerebral arteries during cognitive tasks via functional transcranial Doppler recordings.
abstract: Functional transcranial Doppler (fTCD) is a useful medical imaging technique to monitor cerebral blood flow velocity (CBFV) in major cerebral arteries. In this paper, CBFV changes in the right and left middle cerebral arteries (MCA) caused by cognitive tasks, such as word generation tasks and mental rotation tasks, were examined using fTCD. CBFV recordings were collected from 20 healthy subjects (10 females, 10 males). We obtained both the raw CBFV signal and the envelope CBFV signal, which is the maximal velocity to gain more information about the changes and hemisphere lateralization in cognitive tasks compared to the resting state. Time, frequency, time-frequency, and information-theoretic features were calculated and compared. Sex effects were also taken into consideration. The results of our analysis demonstrated that the raw CBFV signal contained more descriptive information than the envelope signals. Furthermore, both types of cognitive tasks produced higher values in most signal features. Geometric tasks were more distinguished from the rest-state than verbal tasks and the lateralization was exhibited in right MCA during geometric tasks. Our results show that the raw CBFV signals provided valuable information when studying the effects of cognitive tasks and lateralization in the MCA.
authors.affiliation: Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.affiliation: Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: Hanrui
authors.initials: H
authors.lastname: Huang
authors.affiliation: Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Boninger
authors.affiliation: Department of Electrical and Computer Engineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: esejdic@ieee.org.
authors.forename: Ervin
authors.initials: E
authors.lastname: Sejdić
mesh_terms: D065843:Cerebral Crus / Q000000981:diagnostic imaging* / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging*; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D013997:Time Factors; D017585:Ultrasonography, Doppler, Transcranial; D014706:Verbal Learning; D014825:Vocabulary; D055815:Young Adult
keywords: Cerebral blood flow velocity; Cognitive tasks; Functional transcranial Doppler; Rest; Signal characteristics