title: Cerebral vasculitis and encephalitis due to Epstein-Barr virus in a patient with newly diagnosed HIV infection.
abstract: Epstein-Barr virus (EBV) is a common infection which usually produces mild or no symptoms in immunocompetent individuals. In human immunodeficiency virus (HIV) associated immunosuppression it is most commonly associated with malignancy which usually occurs at very low CD4+ cell counts. We describe a newly diagnosed HIV-positive patient who presented with headaches and cerebellar signs. She was incorrectly diagnosed with cerebral tuberculosis (TB) infection based on the histology report from a cerebellar biopsy specimen. After extensive investigation including cerebrospinal fluid sampling and reanalysis of the brain biopsy specimens she was found to have EBV-associated cerebral vasculitis and encephalitis and was successfully treated with valganciclovir and steroids. Whilst there are a few reports of EBV-associated encephalitis, cerebral vasculitis secondary to EBV in the context of HIV infection has not previously been described in the literature.
authors.affiliation: Chelsea and Westminster Hospital, United Kingdom. Electronic address: lavanya.raman10@gmail.com.
authors.forename: Lavanya
authors.initials: L
authors.lastname: Raman
authors.affiliation: Chelsea and Westminster Hospital, United Kingdom. Electronic address: mark.nelson@chelwest.nhs.uk.
authors.forename: Mark
authors.initials: M
authors.lastname: Nelson
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000473:pathology*; D005260:Female; D015774:Ganciclovir / Q000031:analogs & derivatives / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome; D000077562:Valganciclovir; D020293:Vasculitis, Central Nervous System / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000821:virology*
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D013256:Steroids; D000077562:Valganciclovir; D015774:Ganciclovir
keywords: EBV; Encephalitis; HIV; Vasculitis