title: Effect of mobile phase composition on the liquid chromatographic enantioseparation of bulky monoterpene-based β-amino acids by applying chiral stationary phases based on Cinchona alkaloid.
abstract: Stereoselective HPLC separations of five sterically constrained monoterpene-based 2-aminocarboxylic acid enantiomers were carried out by using the newly developed zwitterionic chiral stationary phases Chiralpak ZWIX(+)™ and ZWIX(-)™ based on Cinchona alkaloid. In order to optimize the retention and enantioselectivity parameters, the ratio of the different organic solvents in the mobile phase and the nature of the acid and base additives (counter- and co-ions) were systematically varied. The effects of structure variants of the analytes on the resolution were investigated. The elution sequence was determined in all cases and observed to be opposite on ZWIX(+)™ and ZWIX(-)™.
authors.affiliation: Department of Inorganic and Analytical Chemistry, University of Szeged, Szeged, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Pataj
authors.forename: István
authors.initials: I
authors.lastname: Ilisz
authors.forename: Zsanett
authors.initials: Z
authors.lastname: Gecse
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Szakonyi
authors.forename: Ferenc
authors.initials: F
authors.lastname: Fülöp
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lindner
authors.forename: Antal
authors.initials: A
authors.lastname: Péter
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D002930:Cinchona Alkaloids / Q000737:chemistry*; D008968:Molecular Conformation; D039821:Monoterpenes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002930:Cinchona Alkaloids; D039821:Monoterpenes
keywords: Aminocarboxylic acids; Enantiomeric separation; HPLC; Monoterpenes