title: Radiation therapy for recalcitrant pyoderma gangrenosum.
abstract: Pyoderma gangrenosum is a rare neutrophilic dermatosis, often associated with underlying systemic diseases. Treatment usually consists of topics and sometimes systemic immunosuppression. We present the case of a 32-year-old female patient undergoing radiation therapy for extensive recalcitrant pyoderma gangrenosum in which immunosuppressive measures were ineffective to control the disease. Treatment outcome was favourable with only mild side effects in the irradiated areas. Localized radiation therapy hence is a potential effective palliation for refractory cases of pyoderma gangrenosum, or patients unfit to undergo aggressive systemic immunosuppression.
authors.affiliation: Department of Radiation Oncology Centro di Riferimento Oncologico Aviano, Pordenone, Italy - cfurlan@cro.it.
authors.forename: I A
authors.initials: IA
authors.lastname: Rumeileh
authors.forename: C
authors.initials: C
authors.lastname: Furlan
authors.forename: E
authors.initials: E
authors.lastname: Minatel
authors.forename: M
authors.initials: M
authors.lastname: Mascarin
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001342:Autonomic Nervous System Diseases / Q000150:complications; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods; D002921:Cicatrix / Q000473:pathology / Q000532:radiotherapy; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D004307:Dose-Response Relationship, Radiation; D004351:Drug Resistance; D057915:Drug Substitution; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000069285:Infliximab; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000188:drug therapy / Q000532:radiotherapy*; D011882:Radiotherapy, High-Energy; D013167:Spondylitis, Ankylosing / Q000150:complications; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003520:Cyclophosphamide; D000069285:Infliximab