title: Interaction between systemic inflammation and renal tubular epithelial cells.
abstract: Systemic inflammation is known to target tubular epithelial cells (TECs), leading to acute kidney injury. Tubular cells have been implicated in the response to inflammatory mediators in ischaemic and septic renal damage. Moreover, loss of tubular cells by apoptosis or epithelial-to-mesenchymal transition may ingenerate conditions that lead to progression towards chronic kidney disease. On the other hand, TECs may actively contribute to the production of inflammatory mediators that may propagate the injury locally or in distant organs. In the present review, we discuss the tubular cell response and its contribution to systemic inflammation.
authors.affiliation: Nephrology, Dialysis and Kidney Transplantation Unit, Department of Medical Sciences, University of Torino, Turin, Italy.
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cantaluppi
authors.affiliation: Nephrology, Dialysis and Kidney Transplantation Unit, Department of Medical Sciences, University of Torino, Turin, Italy.
authors.forename: Alessandro Domenico
authors.initials: AD
authors.lastname: Quercia
authors.affiliation: Nephrology, Dialysis and Kidney Transplantation Unit, Department of Medical Sciences, University of Torino, Turin, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Dellepiane
authors.affiliation: Nephrology, Dialysis and Kidney Transplantation Unit, Department of Medical Sciences, University of Torino, Turin, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Ferrario
authors.affiliation: Nephrology, Dialysis and Kidney Transplantation Unit, Department of Medical Sciences, University of Torino, Turin, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Camussi
authors.affiliation: Nephrology, Dialysis and Kidney Transplantation Unit, Department of Medical Sciences, University of Torino, Turin, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Biancone
mesh_terms: D058186:Acute Kidney Injury / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D017209:Apoptosis; D015415:Biomarkers / Q000378:metabolism*; D018450:Disease Progression; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology*; D058750:Epithelial-Mesenchymal Transition; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D007684:Kidney Tubules / Q000378:metabolism / Q000473:pathology*
chemical_list: D015415:Biomarkers
keywords: acute kidney injury; chronic kidney disease; inflammation; mediators; tubular cells