title: Resistin -420C>G promoter variant and colorectal cancer risk.
abstract: OBJECTIVE
  Obesity is associated with an increased risk of colorectal cancer (CRC), and ghrelin (GHRL) and resistin (RETN) are thought to be related to obesity. Our aim was to investigate whether GHRL and RETN gene variants are associated with CRC risk.
  
  
  METHODS
  All 414 subjects, including 197 cases with CRC and 217 controls, were genotyped for the GHRL (rs26802) and RETN (rs1862513) or -420 C>G gene variants using the PCR-RFLP method.
  
  
  RESULTS
  Our findings indicated that the RETN -420 C>G "CC" genotype, compared with the "GG" and "GC" genotypes, was a marker of decreased CRC susceptibility; the difference remained significant after adjustment for age, BMI, gender, smoking status, NSAID use, and family history of CRC (p=0.020; OR=0.52, 95% CI=0.30-0.90). Furthermore, after adjustment for confounding factors, the -420 C>G "CC" genotype, compared with the "GG" genotype, was associated with a decreased risk for CRC (p=0.044; OR=0.53, 95% CI=0.29-0.98). In addition, no significant difference was observed for the GHRL (rs26802) gene variant.
  
  
  CONCLUSIONS
  To our knowledge, this is the first study suggesting that the RETN -420 C>G "CC" genotype is a marker of decreased CRC susceptibility. This observation is relevant from a scientific perspective and deserves further investigations.
authors.affiliation: Gastroenterology and Liver Diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran - Iran.
authors.forename: Touraj
authors.initials: T
authors.lastname: Mahmoudi
authors.forename: Khatoon
authors.initials: K
authors.lastname: Karimi
authors.forename: Maral
authors.initials: M
authors.lastname: Arkani
authors.forename: Hamid
authors.initials: H
authors.lastname: Farahani
authors.forename: Mohsen
authors.initials: M
authors.lastname: Vahedi
authors.forename: Reza
authors.initials: R
authors.lastname: Dabiri
authors.forename: Hossein
authors.initials: H
authors.lastname: Nobakht
authors.forename: Asadollah
authors.initials: A
authors.lastname: Asadi
authors.forename: Mojgan
authors.initials: M
authors.lastname: Mirakhorli
authors.forename: Benafsheh
authors.initials: B
authors.lastname: Arshi
authors.forename: Arash
authors.initials: A
authors.lastname: Derakhshan
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Zali
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D054439:Ghrelin / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D052243:Resistin / Q000235:genetics*
chemical_list: C515349:GHRL protein, human; D054439:Ghrelin; C499624:RETN protein, human; D052243:Resistin