title: A new bisanthraquinone and cytotoxic xanthones from Cratoxylum cochinchinense.
abstract: A new bisanthraquinone has been isolated from the stems of Cratoxylum cochinchinense together with vismiaquinone C and 16 known xanthones. Their structures were characterised by using spectroscopic methods. Two of the isolated compounds are modified xanthones (6 and 15) and exhibited strong cytotoxicity against human epidermoid carcinoma (A341: IC50 2.01, 1.78 μg/mL) and human breast cancer cell lines (SKBR3: IC50 1.54, 0.69 μg/mL).
authors.affiliation: a Department of Chemistry , Faculty of Science, Prince of Songkla University , Hat Yai, Songkhla 90112 , Thailand.
authors.forename: Suthida
authors.initials: S
authors.lastname: Rattanaburi
authors.forename: Mareena
authors.initials: M
authors.lastname: Daus
authors.forename: Ramida
authors.initials: R
authors.lastname: Watanapokasin
authors.forename: Wilawan
authors.initials: W
authors.lastname: Mahabusarakam
mesh_terms: D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D028084:Clusiaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C000591683:1,1',8,8'-tetrahydroxy-3,3'-dimethoxy-6,6'-dimethyl-2'-(3-methyl-2-butenyl)-(4,4'-bianthracene)-9,9',10,10'-tetratrone; D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones
keywords: Cratoxylum cochinchinense; bisanthraquinone; cytotoxicity; xanthones