title: Estrogen signaling crosstalk: Implications for endocrine resistance in ovarian cancer.
abstract: Resistance to anti-estrogen therapies is a prominent challenge in the treatment of ovarian cancer. Tumors develop endocrine resistance by acquiring adaptations that help them rely on alternative oncogenic signaling cascades, which crosstalk with estrogen signaling pathways. An understanding of estrogen signaling crosstalk with these growth promoting cascades is essential in order to maximize efficacy of anti-estrogen treatments in ovarian cancer. Herein, we provide an overview of estrogen signaling in ovarian cancer and discuss the major challenges associated with anti-estrogen therapies. We also review what is currently known about how genomic and non-genomic estrogen signaling pathways crosstalk with several major oncogenic signaling cascades. The insights provided here illustrate existing strategies for targeting endocrine resistant ovarian tumors and may help identify new strategies to improve the treatment of this disease.
authors.affiliation: Brown University, Pathobiology Graduate Program, 70 Ship St., Providence, RI 02903, USA. Electronic address: Jennifer_Wardell@Brown.edu.
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Ribeiro
authors.affiliation: Brown University, Pathobiology Graduate Program, 70 Ship St., Providence, RI 02903, USA; Brown University, Department of Molecular and Cellular Biology and Biochemistry, 70 Ship St., Providence, RI 02903, USA. Electronic address: Richard_Freiman@brown.edu.
authors.forename: Richard N
authors.initials: RN
authors.lastname: Freiman
mesh_terms: D019008:Drug Resistance, Neoplasm; D004703:Endocrine System / Q000187:drug effects*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D004967:Estrogens
keywords: Endocrine resistance; Estradiol; Estrogen receptor; Estrogen signaling; Ovarian cancer