title: Effect of commercial fluoride dentifrices against hydrochloric acid in an erosion-abrasion model.
abstract: OBJECTIVE
  This study assessed the effect of three commercial dentifrices with different fluoride-containing compounds in controlling the progression of dentin loss using an in vitro erosion-abrasion model.
  
  
  METHODS
  Dentin specimens were randomized into four groups (n = 10): control (no F), Elmex (1,400 ppm AmF), Meridol (1,400 ppm AmF/SnF2), and Crest Pro-Health (1,100 ppm SnF2). The dentin specimens were submitted to cycles of demineralization (HCl 0.01 M for 60 s), remineralization (artificial saliva for 60 min), and immersion in 1:3 w/w of dentifrice/artificial saliva, followed by toothbrushing (150 brushing strokes). The cycle was repeated three times daily for 5 days. Surface loss was quantified by stylus profilometry. Data were submitted to one-way ANOVA and Tukey's tests (p < 0.05).
  
  
  RESULTS
  Wear (μm ± SD) was control 4.1 ± 1.2, Elmex 3.7 ± 1.5, Meridol 1.3 ± 0.4, and Crest Pro-Health 2.1 ± 0.7. Therefore, all products (except Elmex) produced statistically significantly less mineral loss (p < 0.05) when compared with the control.
  
  
  CONCLUSIONS
  None of the dentifrices avoided the erosive-abrasive process; however, SnF2-containing dentifrices were effective in statistically significantly reducing dentin loss.
  
  
  CONCLUSIONS
  Scientific literature shows evidence that fluoride can strengthen dental tissue against erosive acid damage. However, the beneficial effect of different fluorides present in commercial dentifrices is questionable. Thus, a determination of an effective fluoride dentifrice may be beneficial in the reduction of the erosive process in patients with gastric disorders.
authors.affiliation: Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, CE, Brazil.
authors.forename: Vanara Florêncio
authors.initials: VF
authors.lastname: Passos
authors.forename: Andréa Araújo
authors.initials: AA
authors.lastname: de Vasconcellos
authors.forename: José Heriberto Pinheiro
authors.initials: JH
authors.lastname: Pequeno
authors.forename: Lidiany Karla Azevedo
authors.initials: LK
authors.lastname: Rodrigues
authors.forename: Sérgio Lima
authors.initials: SL
authors.lastname: Santiago
mesh_terms: D000588:Amines / Q000494:pharmacology; D003802:Dentifrices / Q000494:pharmacology*; D003804:Dentin / Q000187:drug effects*; D003959:Diamines / Q000494:pharmacology; D018450:Disease Progression; D004338:Drug Combinations; D005459:Fluorides / Q000494:pharmacology*; D006801:Humans; D006851:Hydrochloric Acid / Q000494:pharmacology*; D066298:In Vitro Techniques; D010710:Phosphates / Q000494:pharmacology; D011897:Random Allocation; D013499:Surface Properties; D014002:Tin Fluorides / Q000494:pharmacology; D014072:Tooth Abrasion; D014077:Tooth Erosion; D014099:Toothbrushing
chemical_list: D000588:Amines; C510825:Crest Pro-Health Dentifrice; D003802:Dentifrices; D003959:Diamines; D004338:Drug Combinations; D010710:Phosphates; D014002:Tin Fluorides; C059813:Meridol; C495399:Olaflur; D005459:Fluorides; D006851:Hydrochloric Acid