title: Support of academic synthetic chemistry using separation technologies from the pharmaceutical industry.
abstract: The use of state-of-the-art separation tools from the pharmaceutical industry for addressing intractable separation problems from academic synthetic chemistry is evaluated, showing fast and useful results for the resolution of complex mixtures, separation of closely related components, visualization of difficult to detect compounds and purification of synthetic intermediates. Some recommendations for potential near term deployment of separation tools within academia and the evolution of next generation separation technologies are discussed.
authors.affiliation: Merck Research Laboratories, Rahway, New Jersey 07065, USA. christopher_welch@merck.com erik.regalado@merck.com.
authors.forename: Erik L
authors.initials: EL
authors.lastname: Regalado
authors.forename: Marisa C
authors.initials: MC
authors.lastname: Kozlowski
authors.forename: John M
authors.initials: JM
authors.lastname: Curto
authors.forename: Tobias
authors.initials: T
authors.lastname: Ritter
authors.forename: Michael G
authors.initials: MG
authors.lastname: Campbell
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Mazzotti
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Hamper
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Spilling
authors.forename: Michael P
authors.initials: MP
authors.lastname: Mannino
authors.forename: Li
authors.initials: L
authors.lastname: Wan
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
authors.forename: Jinchu
authors.initials: J
authors.lastname: Liu
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Welch
mesh_terms: D005591:Chemical Fractionation / Q000379:methods*; D060326:Chemistry Techniques, Synthetic; D002851:Chromatography, High Pressure Liquid; D025924:Chromatography, Supercritical Fluid; D004345:Drug Industry / Q000379:methods*; D007753:Laboratories; D009930:Organic Chemicals / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D009930:Organic Chemicals