title: [Targeted genome modifications using TALEN].
abstract: Precise modifications of genomes have been one of the biggest goals in the fields of biotechnology and biomedical research. Recent discovery of TALE (transcription activator-like effectors) and the engineering of customized TALEN (transcription activator-like effector nucleases) allowed rapid genome editing in a variety of cell types and different model organisms. TALEN are molecular scissors used to induce a wide range of specific and efficient genomic modifications. TALEN promise to have profound impacts on biological and medical research over the coming years.
authors.affiliation: Inserm U908, université de Lille 1, bâtiment SN3, Cité scientifique, 59655 Villeneuve d'Ascq, France.
authors.forename: Barbara
authors.initials: B
authors.lastname: Dupret
authors.affiliation: Inserm U908, université de Lille 1, bâtiment SN3, Cité scientifique, 59655 Villeneuve d'Ascq, France - Institut de recherche interdisciplinaire, CNRS USR 3078, parc scientifique de la Haute Borne, 50, avenue Halley, 59658 Villeneuve d'Ascq, France.
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Angrand
mesh_terms: D000818:Animals; D004247:DNA / Q000378:metabolism; D004260:DNA Repair; D004720:Endonucleases; D005818:Genetic Engineering; D016678:Genome; D006801:Humans; D015533:Transcriptional Activation
chemical_list: D004247:DNA; D004720:Endonucleases