title: M1 muscarinic acetylcholine receptor in Alzheimer's disease.
abstract: The degeneration of cholinergic neurons and cholinergic hypofunction are pathologies associated with Alzheimer's disease (AD). Muscarinic acetylcholine receptors (mAChRs) mediate acetylcholine-induced neurotransmission and five mAChR subtypes (M1-M5) have been identified. Among them, M1 mAChR is widely expressed in the central nervous system and has been implicated in many physiological and pathological brain functions. In addition, M1 mAChR is postulated to be an important therapeutic target for AD and several other neurodegenerative diseases. In this article, we review recent progress in understanding the functional involvement of M1 mAChR in AD pathology and in developing M1 mAChR agonists for AD treatment.
authors.affiliation: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, 361102, China.
authors.forename: Shangtong
authors.initials: S
authors.lastname: Jiang
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Li
authors.forename: Cuilin
authors.initials: C
authors.lastname: Zhang
authors.forename: Yingjun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Guojun
authors.initials: G
authors.lastname: Bu
authors.forename: Huaxi
authors.initials: H
authors.lastname: Xu
authors.forename: Yun-Wu
authors.initials: YW
authors.lastname: Zhang
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology*; D000818:Animals; D006801:Humans; D043643:Receptor, Muscarinic M1 / Q000378:metabolism*
chemical_list: D043643:Receptor, Muscarinic M1