title: [Comparative study on the clinical characteristics of HBV infection patients with different pathologic inflammation grade].
abstract: OBJECTIVE
  The aim of this study was to compare the biochemical and virological characteristics among patients infected with hepatitis B virus (HBV) according to pathologic inflammation grade.
  
  
  METHODS
  428 patients with chronic HBV infection accept liver biopsy, liver function test, HBeAg detection and HBV DNA levels detection. They were studied and subdivided into four groups according to pathologic inflammation grade. The biochemical and virological characteristics were studied. Univariate analysis was performed with the SPSS 16.0.
  
  
  RESULTS
  In different inflammation grading group, mean age and sex composition were no difference. Serum levels of ALT was highest in group G3 and lowet in group G0-1, there was statistically significant among groups (P = 0.005); AST and TBil were all highest in group G4 and lowest in group G0-1, statistically significant also found among groups (P = 0.000 & 0.004). Serum levels of ALB and PTA were all highest in group G0-1 and lowest in group G4, had statistically significant among groups (P = 0.000 & 0.000). There was no difference of HBV DNA level and percentage of HBeAg (+) among four groups (P = 0.565 & 0.065).
  
  
  CONCLUSIONS
  The serum AST, TBil, ALB and PTA were different and can partly reflect the inflammation degree of liver damage in patients with HBV infection. ALT and PTA can reflect the inflammation degree of G0-1, G2 and G3; AST, TBil, ALB and PTA reflect the G3 and G4. HBV DNA level and HBeAg status can not indicate the inflammation degree in HBV infection patients.
authors.affiliation: Department of Infectious Diseases, Conghua Central Hospital, Guangzhou 510900, China.
authors.forename: Can-Hui
authors.initials: CH
authors.lastname: Xiao
authors.affiliation: Department of Infectious Diseases, Conghua Central Hospital, Guangzhou 510900, China.
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Sun
authors.affiliation: Department of Infectious Diseases, Conghua Central Hospital, Guangzhou 510900, China.
authors.forename: Ka
authors.initials: K
authors.lastname: Zhang
authors.affiliation: Department of Infectious Diseases, Conghua Central Hospital, Guangzhou 510900, China.
authors.forename: Xing-Fei
authors.initials: XF
authors.lastname: Pan
authors.affiliation: Department of Infectious Diseases, Conghua Central Hospital, Guangzhou 510900, China.
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Huang
authors.affiliation: Department of Infectious Diseases, Conghua Central Hospital, Guangzhou 510900, China.
authors.forename: Qi-Huan
authors.initials: QH
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000378:metabolism; D005260:Female; D006509:Hepatitis B / Q000201:enzymology / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D006515:Hepatitis B virus; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000276:immunology / Q000473:pathology / Q000821:virology; D008111:Liver Function Tests; D008297:Male; D055815:Young Adult
chemical_list: D000410:Alanine Transaminase