title: A case of concomitant keratoconus and granular corneal dystrophy type II.
abstract: OBJECTIVE
  We report a Korean case of concomitant keratoconus and granular corneal dystrophy type II.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 29-year-old man visited our clinic for a routine ocular check-up. Slit-lamp examination revealed a few well-circumscribed, greyish-white, discrete granular opacities in the central corneal stromae of both eyes. Direct sequencing of exon 4 of the BIGH3 gene revealed a heterozygous transversion from G to A in the second-nucleotide position of codon 124. In addition, a Fleischer ring and Vogt's striae were evident in the cornea. The corneal topography was suggestive of keratoconus.
  
  
  CONCLUSIONS
  Granular corneal dystrophy type II can co-exist with keratoconus and should be included in the differential diagnosis.
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Chang Rae
authors.initials: CR
authors.lastname: Rho
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jin Hyung
authors.initials: JH
authors.lastname: Park
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Youn-Hea
authors.initials: YH
authors.lastname: Jung
authors.affiliation: Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. Electronic address: mskim@catholic.ac.kr.
authors.forename: Man Soo
authors.initials: MS
authors.lastname: Kim
mesh_terms: D000328:Adult; D003317:Corneal Dystrophies, Hereditary / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D019781:Corneal Topography; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D006801:Humans; D007640:Keratoconus / Q000150:complications / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016212:Transforming Growth Factor beta / Q000235:genetics*; D000099222:betaIG-H3 Protein
chemical_list: D016326:Extracellular Matrix Proteins; D016212:Transforming Growth Factor beta; D000099222:betaIG-H3 Protein
keywords: BIGH3; Corneal topography; Granular corneal dystrophy; Keratoconus