title: Transient regional osteoporosis.
abstract: Transient regional osteoporosis (TRO) is a disease that predisposes to fragility fracture in weight bearing joints of mid-life women and men. Pregnant women may also suffer the process, usually at the hip. The prevalence of TRO is lower than the systemic form, associated with postmenopause and advanced age, but may be falsely diminished by under-diagnosis. The disease may be uni- or bilateral, and may migrate to distinct joints. One main feature of TRO is spontaneous recovery. Pain and progressive limitation in the functionality of the affected joint(s) are key symptoms. In the case of the form associated with pregnancy, difficulties in diagnosis derive from the relatively young age at presentation and from the clinical overlapping with the frequent aches during gestation. Densitometric osteoporosis in the affected region is not always present, but bone marrow edema, with or without joint effusion, is detected by magnetic resonance. There are not treatment guidelines, but the association of antiresorptives to symptomatic treatment seems to be beneficial. Surgery or other orthopedic interventions can be required for specific indications, like hip fracture, intra-medullary decompression, or other.
authors.affiliation: Radiology Service, University General Hospital, Av Benicassim s/n, 12004 Castellon, Spain. Electronic address: AntonioJCano@hotmail.com.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cano-Marquina
authors.affiliation: Department of Functional Biology and Physical Anthropology, School of Biological Sciences, Burjasot Campus, University of Valencia, Valencia, Spain. Electronic address: Juan.J.Tarin@uv.es.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Tarín
authors.affiliation: Department of Genetics, University of Valencia and Research Foundation, INCLIVA, Av Blasco Ibáñez 15, 46010 Valencia, Spain. Electronic address: Miguel.Garcia@uv.es.
authors.forename: Miguel-Ángel
authors.initials: MÁ
authors.lastname: García-Pérez
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital Dr Peset, Av Gaspar Aguilar 90, 46017 Valencia, Spain; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, Av Blasco Ibáñez 15, 46010 Valencia, Spain. Electronic address: Antonio.Cano@uv.es.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cano
mesh_terms: D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D010024:Osteoporosis / Q000503:physiopathology* / Q000628:therapy; D011247:Pregnancy
keywords: Fracture; Migratory osteoporosis; Pregnancy; Transient regional osteoporosis