title: Durable HIV RNA resuppression after virologic failure while  remaining on a first-line regimen: a cohort study.
abstract: Adherence interventions are a recommended strategy to salvage failing antiretroviral therapy without regimen change. We assessed the durability of resuppression when using this approach. Of 300 patients who resuppressed on the same regimen (41% of all those with virologic failure), 148 (45%) remained suppressed during follow-up for a median of 2.4 years (interquartile range [IQR]: 1.1, 4.0). Resuppression can be durable following viraemia without a switch in antiretroviral therapy regimen.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Hoffmann
authors.forename: Salome
authors.initials: S
authors.lastname: Charalambous
authors.forename: Alison D
authors.initials: AD
authors.lastname: Grant
authors.forename: Lynn
authors.initials: L
authors.lastname: Morris
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: Churchyard
authors.forename: Richard E
authors.initials: RE
authors.lastname: Chaisson
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D006678:HIV / Q000235:genetics*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008875:Middle Aged; D012367:RNA, Viral; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral