title: 'Rapid tranquillisation': an historical perspective on its emergence in the context of the development of antipsychotic medications.
abstract: This paper examines factors involved in the theory and practice of emergency sedation for behavioural disturbance in psychiatry in the mid-twentieth century, and the emergence of the concept of 'rapid tranquillisation'. The practice received little attention until the arrival of antipsychotic drugs, which replaced older sedatives and became the agents most strongly associated with the treatment of aggression and challenging behaviour. Emergency sedation was subsequently portrayed in psychiatric literature and advertising as a therapeutic and diagnosis-driven endeavour, and the concept of rapid tranquillisation emerged in this context in the 1970s. Use of non-antipsychotic sedatives, like the benzodiazepines, is barely visible in contemporary sources, and the research suggests that antipsychotics became the mainstay of rapid tranquillisation strategies because of beliefs about their specific therapeutic properties in psychosis and schizophrenia, and not because of demonstrated superiority over other agents.
authors.affiliation: Camden and Islington Mental Health Foundation Trust, London.
authors.forename: Laura
authors.initials: L
authors.lastname: Allison
authors.forename: Joanna
authors.initials: J
authors.lastname: Moncrieff
mesh_terms: D014150:Antipsychotic Agents / Q000266:history* / Q000627:therapeutic use; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D006993:Hypnotics and Sedatives / Q000266:history* / Q000627:therapeutic use; D011600:Psychopharmacology / Q000266:history*; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D006993:Hypnotics and Sedatives
keywords: Chemical restraint; haloperidol; history of antipsychotics; history of psychopharmacology; rapid tranquillisation