title: Live birth after frozen-thawed oocytes matured in vitro in a PCOS patient: a model for improving implantation rates in IVM cycles and objectively assessing the real potential of development of frozen oocytes matured in vitro.
abstract: Over the past 20 years, in vitro maturation (IVM) of oocytes has emerged in the strategy of infertility treatment, with the main indication being in patients suffering from polycystic ovarian syndrome (PCOS). More recently, IVM has been proposed as an option for fertility preservation in women having to undergo gonadotoxic treatments. However, despite the increasing application of IVM, the potential of development of in vitro matured oocytes after thawing remains ill-established and few pregnancies have been reported so far. We report herein a case of live birth after frozen-thawed oocytes matured in vitro and embryo transfer during an artificial cycle in a 29-year-old patient with primary infertility due to PCOS. The present case demonstrates that the transfer of frozen-thawed IVM oocytes during an artificial cycle in PCOS patients is feasible and leads to pregnancy and live birth. This strategy may also be an interesting option to objectively assess the developmental potential of these oocytes after freezing and thawing, which is a major concern for physicians who include the IVM approach in their fertility preservation program.
authors.affiliation: AP-HP, Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère , Clamart , France .
authors.forename: Hady
authors.initials: H
authors.lastname: El Hachem
authors.forename: Marine
authors.initials: M
authors.lastname: Poulain
authors.forename: Astrid
authors.initials: A
authors.lastname: Finet
authors.forename: Renato
authors.initials: R
authors.lastname: Fanchin
authors.forename: Nelly
authors.initials: N
authors.lastname: Frydman
authors.forename: Michael H
authors.initials: MH
authors.lastname: Grynberg
mesh_terms: D000328:Adult; D015925:Cryopreservation; D004351:Drug Resistance; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology; D006801:Humans; D059471:In Vitro Oocyte Maturation Techniques; D007247:Infertility, Female / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D050498:Live Birth; D008954:Models, Biological; D054315:Oocyte Retrieval; D009865:Oocytes / Q000473:pathology; D009866:Oogenesis / Q000187:drug effects; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011247:Pregnancy; D020554:Sperm Injections, Intracytoplasmic; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female
keywords: Fertility preservation; implantation; in vitro maturation of oocytes; ovarian hyper-stimulation syndrome; polycystic ovary syndrome