title: Pneumonectomy after response to gefitinib treatment for lung adenocarcinoma.
abstract: A 69-year-old Japanese woman who had never smoked had lung adenocarcinoma harboring epidermal growth factor receptor mutation. After 8 months of gefitinib treatment, salvage pneumonectomy was performed. Microscopic examination showed that non-responsive adenocarcinoma remained although necrosis was prominent. Postoperatively, the patient developed empyema that was successfully managed. The postoperative empyema after treatment with gefitinib should be noted, as well as the finding that residual viable tumor cells remained even after the dramatic radiographic response.
authors.affiliation: Department of General Thoracic Surgery, National Hospital Organization Toneyama Hospital, Toyonaka, Osaka, Japan.
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Funakoshi
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Hajime
authors.initials: H
authors.lastname: Maeda
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D000077192:Adenocarcinoma of Lung; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D016724:Empyema, Pleural / Q000209:etiology; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008197:Lymph Node Excision; D009154:Mutation; D020360:Neoadjuvant Therapy; D018365:Neoplasm, Residual; D011013:Pneumonectomy / Q000009:adverse effects; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; C512478:EGFR protein, human; D066246:ErbB Receptors; D000077156:Gefitinib
keywords: Antineoplastic agents; epidermal growth factor receptor; gefitinib; non-small-cell carcinoma; salvage therapy