title: The carbomethylation of arylacrylamides leading to 3-ethyl-3-substituted indolin-2-one by cascade radical addition/cyclization.
abstract: An FeCl2-promoted carbomethylation of arylacrylamides by di-tert-butyl peroxide (DTBP) is achieved, leading to 3-ethyl-3-substituted indolin-2-one in high yield. The reaction tolerates a series of functional groups, such as cyano, nitro, ethyloxy carbonyl, bromo, chloro, and trifluoromethyl groups. The radical methylation and arylation of the alkenyl group are involved in this reaction.
authors.affiliation: School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, and Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Changzhou University, Changzhou, 213164, P. R. China. jiangcheng@cczu.edu.cn.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Dai
authors.forename: Jintao
authors.initials: J
authors.lastname: Yu
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Songjin
authors.initials: S
authors.lastname: Guo
authors.forename: Haitao
authors.initials: H
authors.lastname: Yang
authors.forename: Jiang
authors.initials: J
authors.lastname: Cheng
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004579:Electron Transport; D005296:Ferrous Compounds / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D008745:Methylation; D010545:Peroxides / Q000737:chemistry*
chemical_list: D000178:Acrylamides; D005296:Ferrous Compounds; D007211:Indoles; D010545:Peroxides; C456900:indolin-2-one; C111570:di-tert-butyl peroxide; C029451:ferrous chloride