title: Association of T869, C509T, G915C gene polymorphism of transforming growth factor-β1 with IgA nephropathy risk.
abstract: This meta-analysis was conducted to assess the association of transforming growth factor-β1 (TGF-β1) T869C, C509T, G915C gene polymorphism with the risk of IgA nephropathy (IgAN). The association literatures were identified from PubMed, Cochrane Library up to October 1, 2013, and eligible reports were recruited and synthesized. Five reports were recruited into this meta-analysis for the association of TGF-β1 T869C, C509T, G915C gene polymorphism with IgAN risk. In this meta-analysis, the association of TGF-β1 T869C, C509T, G915C gene polymorphism with IgAN risk was not found. In conclusion, TGF-β1 T869C, C509T, G915C gene polymorphism is not associated with the IgAN risk. However, more studies should be performed in the future to confirm this association.
authors.affiliation: Department of Nephrology .
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Guo
authors.forename: Sheng-Sheng
authors.initials: SS
authors.lastname: Yin
mesh_terms: D020022:Genetic Predisposition to Disease; D005922:Glomerulonephritis, IGA / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1
keywords: C509T; G915C; IgA nephropathy; T869C; gene polymorphism; meta-analysis; transforming growth factor-β1