title: The Association between KIF6 Single Nucleotide Polymorphism rs20455 and Serum Lipids in Filipino-American Women.
abstract: The Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein cholesterol (LDL-C), was investigated in Filipino-American women (FAW, n = 235) participating in health screenings in four cities. The rs20455 genotype of each subject was determined by a multiplex assay using a Luminex-OLA procedure. The risk allele Trp719Arg was present in 77% of the subjects. The genotype distribution was 23% Trp/Trp, 51% Arg/Trp, and 26% Arg/Arg. Genotype did not predict the presence of CHD risk factors. Moreover, LDL-C, HDL-C, and triglycerides mean values did not vary as a function of genotype. However, those with the Arg/Arg genotype on statin medication exhibited a significantly higher mean triglycerides level (P < 0.01). Approximately 60% of participants regardless of genotype exhibited LDL-C levels ≥100 mg/dL but were not taking medication. Approximately 43% of those with the Trp719Arg risk allele on statins exhibited elevated LDL-C levels. Our study suggests that the Trp719Arg allele of KIF 6 rs20455 is common among Filipino-American women; thus, even with borderline LDL-C levels would benefit from statin treatment. Secondly, many participants did not exhibit guideline recommended LDL-C levels including many who were on statin drugs.
authors.affiliation: School of Nursing, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USA.
authors.forename: Irma B
authors.initials: IB
authors.lastname: Ancheta
authors.affiliation: School of Nursing, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USA.
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Battie
authors.affiliation: School of Nursing, University of North Florida, 1 UNF Drive, Jacksonville, FL 32224, USA.
authors.forename: Dan
authors.identifier: 0000-0002-6896-7694
authors.initials: D
authors.lastname: Richard
authors.affiliation: University of South Florida, Tampa, FL 33612, USA.
authors.forename: Christine V
authors.initials: CV
authors.lastname: Ancheta
authors.affiliation: East Coast Institute for Research, Jacksonville, FL 32223, USA.
authors.forename: Nancy
authors.identifier: 0000-0002-9727-300X
authors.initials: N
authors.lastname: Borja-Hart
authors.affiliation: Rush University Medical Center, Chicago, IL 60612, USA.
authors.forename: Annabelle S
authors.initials: AS
authors.lastname: Volgman
authors.affiliation: University Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Yvette
authors.initials: Y
authors.lastname: Conley