title: Paclitaxel: new uses for an old drug.
abstract: Paclitaxel (Taxol), one of the most important anticancer drugs, has been used for therapy of different types of cancers. Mechanistically, paclitaxel arrests cell cycle and induces cell death by stabilizing microtubules and interfering with microtubule disassembly in cell division. Recently, it has been found that low-dose paclitaxel seems promising in treating non-cancer diseases, such as skin disorders, renal and hepatic fibrosis, inflammation, axon regeneration, limb salvage, and coronary artery restenosis. Future studies need to understand the mechanisms underlying these effects in order to design therapies with specificity.
authors.affiliation: Departments of Emergency Medicine and Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China ; Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, GA, USA.
authors.forename: Dongshan
authors.initials: D
authors.lastname: Zhang
authors.affiliation: Departments of Emergency Medicine and Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Ruhao
authors.initials: R
authors.lastname: Yang
authors.affiliation: Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, GA, USA.
authors.forename: Shixuan
authors.initials: S
authors.lastname: Wang
authors.affiliation: Departments of Emergency Medicine and Nephrology, Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China ; Department of Cellular Biology and Anatomy, Medical College of Georgia, Georgia Regents University and Charlie Norwood VA Medical Center, Augusta, GA, USA.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Dong
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D023903:Coronary Restenosis / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D023821:Limb Salvage; D009416:Nerve Regeneration / Q000187:drug effects; D017239:Paclitaxel / Q000494:pharmacology / Q000627:therapeutic use*; D011658:Pulmonary Fibrosis / Q000188:drug therapy; D051197:Toll-Like Receptor 4 / Q000502:physiology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D051197:Toll-Like Receptor 4; D017239:Paclitaxel
keywords: coronary artery restenosis; fibrosis; kidney; limb salvage; taxol inflammation