title: A tensor-based population value decomposition to explain rectal toxicity after prostate cancer radiotherapy.
abstract: In prostate cancer radiotherapy the association between the dose distribution and the occurrence of undesirable side-effects is yet to be revealed. In this work a method to perform population analysis by comparing the dose distributions is proposed. The method is a tensor-based approach that generalises an existing method for 2D images and allows for the highlighting of over irradiated zones correlated with rectal bleeding after prostate cancer radiotherapy. Thus, the aim is to contribute to the elucidation of the dose patterns correlated with rectal toxicity. The method was applied to a cohort of 63 patients and it was able to build up a dose pattern characterizing the difference between patients presenting rectal bleeding after prostate cancer radiotherapy and those who did not.
authors.affiliation: INSERM, U 1099, Rennes, F-35000, France. jdospina@unal.edu.co
authors.forename: Juan David
authors.initials: JD
authors.lastname: Ospina
authors.affiliation: INSERM, U 1099, Rennes, F-35000, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Commandeur
authors.affiliation: INSERM, U 1099, Rennes, F-35000, France.
authors.forename: Richard
authors.initials: R
authors.lastname: Ríos
authors.affiliation: INSERM, U 1099, Rennes, F-35000, France.
authors.forename: Gaël
authors.initials: G
authors.lastname: Dréan
authors.affiliation: Universidad Nacional de Colombia, Campus Medellín, Colombia.
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Correa
authors.affiliation: INSERM, U 1099, Rennes, F-35000, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Simon
authors.affiliation: INSERM, U 1099, Rennes, F-35000, France.
authors.forename: Pascal
authors.initials: P
authors.lastname: Haigron
authors.affiliation: INSERM, U 1099, Rennes, F-35000, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: de Crevoisier
authors.affiliation: INSERM, U 1099, Rennes, F-35000, France.
authors.forename: Oscar
authors.initials: O
authors.lastname: Acosta
mesh_terms: D015331:Cohort Studies; D056324:Diffusion Tensor Imaging / Q000379:methods*; D006471:Gastrointestinal Hemorrhage / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000150:complications / Q000473:pathology / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology*; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods; D061089:Radiotherapy, Image-Guided / Q000009:adverse effects* / Q000379:methods; D012002:Rectal Diseases / Q000209:etiology / Q000473:pathology*; D016896:Treatment Outcome