title: Pharmacokinetics of sulfamonomethoxine in tongue sole (Cynoglossus semilaevis) after intravenous and oral administration.
abstract: The pharmacokinetic profiles of sulfamonomethoxine (SMM) were investigated in flatfish tongue soles in the present study. After a single injection of SMM (40 mg/kg BW) to caudal vein of tongue sole at 20 °C, plasma drug concentration versus time data were best fitted to a three-compartment model, characterized with 0.2, 5.7, and 80.4 h for the half-life (t 1/2) of fast distribution, slow distribution, and elimination, respectively. The apparent volume of distribution was 0.1 L/kg, and the body clearance was 0.03 L/h/kg. After oral administration of SMM (200 mg/kg BW) to tongue soles at 20 °C, plasma drug concentrations were best fitted to a two-compartment model, of which the mean half-life of absorption (t 1/2ka) and elimination (t 1/2β ) were 1.7 and 95.7 h, respectively. The maximal absorption concentration (C max) was estimated as 58 mg/L at 2.5 h, and the mean systemic bioavailability (F) was 39.5 % in tongue soles after oral administration.
authors.affiliation: Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, No. 106 Nanjing Road, Qingdao, 266071, People's Republic of China, changzq@ysfri.ac.cn.
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Chang
authors.forename: Zhao-Xin
authors.initials: ZX
authors.lastname: Li
authors.forename: Jing-Bao
authors.initials: JB
authors.lastname: Li
authors.forename: Ying-Zi
authors.initials: YZ
authors.lastname: Wang
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D061605:Administration, Intravenous; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005412:Flatfishes / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D015233:Models, Statistical; D013422:Sulfamonomethoxine / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D013422:Sulfamonomethoxine