title: Prioritization of research addressing antipsychotics for adolescents and young adults with bipolar disorder.
abstract: Despite a paucity of high-quality evidence about benefits and harms, antipsychotic medication use among adolescents and young adults with bipolar disorder is increasing. The Patient-Centered Outcomes Research Institute tasked the Duke Evidence Synthesis Group with creating a prioritized agenda for research in this area that would incorporate the perspectives of relevant stakeholders. We identified a list of potential evidence gaps by reviewing existing literature and engaged a diverse group of 9 stakeholders to expand and refine this list. Using a forced-ranking prioritization method, stakeholders prioritized 10 of 23 potential evidence gaps as the most pressing for future research. These evidence gaps relate to 3 areas: the comparative effectiveness of intervention strategies, the effect of antipsychotics on patient-centered outcomes, and the influence of various patient characteristics on antipsychotic effectiveness. In addition to presenting these findings, we suggest appropriate study designs for addressing the stakeholder-prioritized research questions.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Crowley
authors.forename: Douglas C
authors.initials: DC
authors.lastname: McCrory
authors.forename: Ranee
authors.initials: R
authors.lastname: Chatterjee
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Gierisch
authors.forename: Evan R
authors.initials: ER
authors.lastname: Myers
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Schmit
authors.forename: Remy R
authors.initials: RR
authors.lastname: Coeytaux
authors.forename: Christoph U
authors.initials: CU
authors.lastname: Correll
authors.forename: Amy S
authors.initials: AS
authors.lastname: Kendrick
authors.forename: Gillian D
authors.initials: GD
authors.lastname: Sanders
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy*; D057186:Comparative Effectiveness Research; D019317:Evidence-Based Medicine; D005544:Forecasting; D006801:Humans; D063868:Patient Outcome Assessment; D012106:Research; D012107:Research Design; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents