title: Does APOE genotype modify the relations between serum lipid and erythrocyte omega-3 fatty acid levels?
abstract: Earlier reports indicated that patients with the apolipoprotein APOE ε4 allele responded to fish oil supplementation with a rise in serum low-density lipoprotein cholesterol (LDL-C) compared to ε3 homozygotes. In this study, we used clinical laboratory data to test the hypothesis that the cross-sectional relation between RBC omega-3 fatty acid status (the Omega-3 Index) and LDL-C was modified by APOE genotype. Data from 136,701 patients were available to compare lipid biomarker levels across Omega-3 Index categories associated with heart disease risk in all APOE genotypes. We found no adverse interactions between APOE genotype and the Omega-3 Index for LDL-C, LDL particle number, apoB, HDL-C, or triglycerides. However, we did find evidence that ε2 homozygotes lack an association between omega-3 status and LDL-C, apoB, and LDL particle number. In summary, we found no evidence for a deleterious relationship between lipid biomarkers and the Omega-3 Index by APOE genotype.
authors.affiliation: Health Diagnostic Laboratory, Inc., 737 N. 5th St, Suite 103, Richmond, VA, 23219, USA, bharris@hdlabinc.com.
authors.forename: William S
authors.initials: WS
authors.lastname: Harris
authors.forename: James V
authors.initials: JV
authors.lastname: Pottala
authors.forename: Dawn L
authors.initials: DL
authors.lastname: Thiselton
authors.forename: Stephen
authors.initials: S
authors.lastname: A Varvel
authors.forename: Alison M
authors.initials: AM
authors.lastname: Baedke
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Dayspring
authors.forename: G Russell
authors.initials: GR
authors.lastname: Warnick
authors.forename: Joseph P
authors.initials: JP
authors.lastname: McConnell
mesh_terms: D000328:Adult; D000368:Aged; D053299:Apolipoprotein B-100 / Q000097:blood; D001057:Apolipoproteins E / Q000235:genetics*; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D003430:Cross-Sectional Studies; D004912:Erythrocytes / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D014280:Triglycerides / Q000097:blood
chemical_list: C569471:APOB protein, human; D053299:Apolipoprotein B-100; D001057:Apolipoproteins E; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015525:Fatty Acids, Omega-3; D014280:Triglycerides