title: A targeted theranostic platinum(IV) prodrug containing a luminogen with aggregation-induced emission (AIE) characteristics for in situ monitoring of drug activation.
abstract: A targeted theranostic platinum(IV) prodrug based on a luminogen with aggregation-induced emission (AIE) characteristics was developed for selective and real-time monitoring of drug activation in situ.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore117576. cheliub@nus.edu.sg.
authors.forename: Youyong
authors.initials: Y
authors.lastname: Yuan
authors.forename: Yilong
authors.initials: Y
authors.lastname: Chen
authors.forename: Ben Zhong
authors.initials: BZ
authors.lastname: Tang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D061986:MCF-7 Cells; D018613:Microscopy, Confocal; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism; D010984:Platinum / Q000737:chemistry*; D011355:Prodrugs / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D011725:Pyridines / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D005456:Fluorescent Dyes; D009842:Oligopeptides; D011355:Prodrugs; D011725:Pyridines; D010984:Platinum; C047981:arginyl-glycyl-aspartic acid; C023666:pyridine