title: Nickel (II) incorporated AlPO-5 modified carbon paste electrode for determination of thioridazine in human serum.
abstract: In this approach, synthesis of nickel (II) incorporated aluminophosphate (NiAlPO-5) was performed by using hydrothermal method. The diffuse reflectance spectroscopy (DRS), scanning electron microscopy (SEM), and Fourier transform infrared spectroscopy (FTIR) techniques were applied in order to characterize synthesized compounds. The NiAlPO-5 was used as a modifier in carbon paste electrode for the selective determination of thioridazine which is an antidepressant drug. This research is the first example of an aluminophosphate being employed in electroanalysis. The effective catalytic role of the modified electrode toward thioridazine oxidation can be attributed to the electrocatalytic activity of nickel (II) in the aluminaphosphate matrix. In addition, NiAlPO-5 has unique properties such as the high specific surface area which increases the electron transfer of thioridazine. The effects of varying the percentage of modifier, pH and potential sweep rate on the electrode response were investigated. Differential pulse voltammetry was used for quantitative determination as a sensitive method. A dynamic linear range was obtained in the range of 1.0×10(-7)-1.0×10(-5)mol L(-1). The determination of thioridazine in real samples such as commercial tablets and human serum was demonstrated.
authors.affiliation: Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, Iran. Electronic address: mandanaamiri@uma.ac.ir.
authors.forename: Mandana
authors.initials: M
authors.lastname: Amiri
authors.affiliation: Department of Chemistry, Faculty of Science, University of Guilan, P.O. Box 1914, Rasht. Iran.
authors.forename: Shabnam
authors.initials: S
authors.lastname: Sohrabnezhad
authors.affiliation: Department of Chemistry, University of Mohaghegh Ardabili, Ardabil, Iran.
authors.forename: Azad
authors.initials: A
authors.lastname: Rahimi
mesh_terms: D017607:Aluminum Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D000928:Antidepressive Agents / Q000032:analysis* / Q000097:blood; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction; D010710:Phosphates / Q000138:chemical synthesis / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry; D013881:Thioridazine / Q000032:analysis* / Q000097:blood
chemical_list: D017607:Aluminum Compounds; D000928:Antidepressive Agents; D010710:Phosphates; D013607:Tablets; D002244:Carbon; D009532:Nickel; D013881:Thioridazine
keywords: Carbon paste; Electrochemical sensor; Nickel incorporated aluminophosphate; Thioridazine