title: Therapy with stem cells in inflammatory bowel disease.
abstract: Inflammatory bowel disease (IBD) affects a part of the young population and has a strong impact upon quality of life. The underlying etiology is not known, and the existing treatments are not curative. Furthermore, a significant percentage of patients are refractory to therapy. In recent years there have been great advances in our knowledge of stem cells and their therapeutic applications. In this context, autologous hematopoietic stem cell transplantation (HSCT) has been used in application to severe refractory Crohn's disease (CD), with encouraging results. Allogenic HSCT would correct the genetic defects of the immune system, but is currently not accepted for the treatment of IBD because of its considerable risks. Mesenchymal stem cells (MSCs) have immune regulatory and regenerative properties, and low immunogenicity (both autologous and allogenic MSCs). Based on these properties, MSCs have been used via the systemic route in IBD with promising results, though it is still too soon to draw firm conclusions. Their local administration in perianal CD is the field where most progress has been made in recent years, with encouraging results. The next few years will be decisive for defining the role of such therapy in the management of IBD.
authors.affiliation: María del Pilar Martínez-Montiel, Gonzalo Jesús Gómez-Gómez, IBD Unit, Department of Gastroenterology, Universitary Hospital 12 Octubre, 28041 Madrid, Spain.
authors.forename: María Del Pilar
authors.initials: Mdel P
authors.lastname: Martínez-Montiel
authors.affiliation: María del Pilar Martínez-Montiel, Gonzalo Jesús Gómez-Gómez, IBD Unit, Department of Gastroenterology, Universitary Hospital 12 Octubre, 28041 Madrid, Spain.
authors.forename: Gonzalo Jesús
authors.initials: GJ
authors.lastname: Gómez-Gómez
authors.affiliation: María del Pilar Martínez-Montiel, Gonzalo Jesús Gómez-Gómez, IBD Unit, Department of Gastroenterology, Universitary Hospital 12 Octubre, 28041 Madrid, Spain.
authors.forename: Ana Isabel
authors.initials: AI
authors.lastname: Flores
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D003424:Crohn Disease / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D007422:Intestines / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D045164:Mesenchymal Stem Cell Transplantation / Q000009:adverse effects; D016896:Treatment Outcome
keywords: Crohn’s disease; Haematopoietic stem cell transplantation; Inflammatory bowel disease; Mesenchymal stem cell; Ulcerative colitis