title: A mock circulatory system to assess the performance of continuous-flow left ventricular assist devices (LVADs): does axial flow unload better than centrifugal LVAD?
abstract: Hemodynamic performances comparisons between different types of left ventricular assist devices (LVADs) remain difficult in a clinical context. The aim of this study was to create an experimental model to assess and compare two types of LVAD under hemodynamic conditions that simulated physical effort and pulmonary hypertension. An experimental mock circulatory system was created to simulate the systemic and pulmonary circulations and consisted of pulsatile left and right cardiac simulators (cardiowest pump), air/water tanks to model compliances, and tubes to model the venous and arterial resistances. Two types of continuous-flow ventricular assist devices were connected to this pulsated model: an axial flow pump, Heartmate II (HTM II), and a centrifugal pump, VentrAssist (VTA). The hemodynamic conditions at rest and during exercise were replicated. Mean aortic pressures were not significantly different at rest and during effort but mean flow under maximum pump speed was higher with HTM II (13 L vs. 10 L, p = 0.02). Left atrial pressure was lower at rest and during effort for the HTM II (11 mm Hg vs. 3 mm Hg, p = 0.02 and 9 mm Hg vs. 2 mm Hg, p = 0.008) than with the VTA, but with greater risk of left-ventricle suck-down for the axial flow. Power consumption for a similar flow was lower with the VTA during rest (4.7 W vs. 6.9 W, p = 0.002) and during effort (4.3 W vs. 6.6 W, p = 0.008). In case of high pulmonary vascular resistance with preserved right ventricular function, lower right ventricular pressure was obtained with HTM II (21 mm Hg vs. 28 mm Hg, p = 0.03). Observed results are in favor of a better discharge of the left and right cavities with the HTM II compared to the VTA yet with a higher risk of left cavity collapse occurrence.
authors.affiliation: From the *Department of Thoracic and Cardiovascular Surgery, Thorax Institut, Nantes Hospital University, Nantes, France; and †Department of Thoracic and Cardiovascular Surgery, Papworth Hospital NHS Foundation, Cambridge, United Kingdom.
authors.forename: Thomas
authors.initials: T
authors.lastname: Sénage
authors.forename: Dorothée
authors.initials: D
authors.lastname: Février
authors.forename: Magali
authors.initials: M
authors.lastname: Michel
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Pichot
authors.forename: Daniel
authors.initials: D
authors.lastname: Duveau
authors.forename: Steven
authors.initials: S
authors.lastname: Tsui
authors.forename: Jean Noel
authors.initials: JN
authors.lastname: Trochu
authors.forename: Jean Christian
authors.initials: JC
authors.lastname: Roussel
mesh_terms: D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011673:Pulsatile Flow / Q000502:physiology*