title: Honey improves healing of circumscribed excision injury to the paniculus adiposus in albino rats.
abstract: BACKGROUND
  Honey promoteswound healing.
  
  
  OBJECTIVE
  In this study, we described the anatomical perspective of honey on wound healing in male rats.
  
  
  METHODS
  The twenty-four male rats used were randomly divided equally into treated Experimental (E) and Control (C) groups. Infliction of wound done under anaesthesia; honey was used for wound dressing in E, distilled water firmly held by plaster in C. Monitoring of wound contraction were carried out at the interval of three days till the wound healed. The histology of granulation tissue excised from the wounds of rats was also done.
  
  
  RESULTS
  Mean wound contraction (%) of rats in E on days 3, 6, and 9 were: 35.32 +/- 5.5; 57.56 +/- 0.7 and 82.30 +/- 0.9% compared to 26.50 +/- 1.2; 46.69 +/- 0.4 and 61.24 +/- 1.0% of rats in C. Honey treated groups showed significant increase (p < 0.05) in percentage of wound contraction in all treatment days. Complete wound closure day was also significantly shorter. On day 3, E showed a more intense infiltration by neutrophils and macrophages as well as features suggestive of edema and necrosis. On day 9, the connective tissues of E revealed markedly increased fibroblasts, less neutrophils, and presence of numerous new capillary blood vessels.
  
  
  CONCLUSIONS
  The use of honey accelerates the wound healing process.
authors.affiliation: Department of Anatomy, College of Medicine, University of Port Harcourt, River state, Nigeria.
authors.forename: O I
authors.initials: OI
authors.lastname: Osuegbu
authors.affiliation: Department of Anatomy College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria.
authors.forename: O E
authors.initials: OE
authors.lastname: Yama
authors.affiliation: Department of Anatomy, College of Medicine, University of Port Harcourt, River state, Nigeria.
authors.forename: E I
authors.initials: EI
authors.lastname: Edibamode
authors.affiliation: Department of Morbid Anatomy, College of Medicine, University of Lagos, Nigeria.
authors.forename: N A
authors.initials: NA
authors.lastname: Awolola
authors.affiliation: Lagos University Medical Sciences, College of Medicine, University of Lagos, Lagos Nigeria.
authors.forename: A B
authors.initials: AB
authors.lastname: Clement
authors.affiliation: Department of Anatomy College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria.
authors.forename: C I
authors.initials: CI
authors.lastname: Amah
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006722:Honey; D008264:Macrophages / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*