title: Imaging: high relaxivities and strong vascular signal enhancement for NaGdF4 nanoparticles designed for dual MR/optical imaging (Adv. Healthcare Mater. 11/2013).
abstract: Tripositive gadolinium-ion doped NIR-to-NIR upconverting paramagnetic nanoparticles are efficiently detected are NIR imaging techniques but can also provide efficient "positive" contrast in MRI. On page 1478 John A. Capobianco, Marc-André Fortin, and co-workers show that citrate-coated nanoparticles present the lowest relaxometric ratios reported for NaGdF4 nanoparticle suspensions. IV-injected nanoparticles evidence long blood retention times in mice while biodistribution studies show elimination through the reticuloendothelial and urinary systems.
authors.affiliation: Department of Chemistry and Biochemistry and Centre for NanoScience Research, Concordia University, Montréal, Québec, H4B 1R6, Canada.
authors.forename: Rafik
authors.initials: R
authors.lastname: Naccache
authors.forename: Pascale
authors.initials: P
authors.lastname: Chevallier
authors.forename: Jean
authors.initials: J
authors.lastname: Lagueux
authors.forename: Yves
authors.initials: Y
authors.lastname: Gossuin
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.forename: Luce
authors.initials: L
authors.lastname: Vander Elst
authors.forename: Cornelia
authors.initials: C
authors.lastname: Chilian
authors.forename: John A
authors.initials: JA
authors.lastname: Capobianco
authors.forename: Marc-André
authors.initials: MA
authors.lastname: Fortin
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000473:pathology*; D005682:Gadolinium; D008279:Magnetic Resonance Imaging; D051379:Mice; D053758:Nanoparticles; D061848:Optical Imaging; D012815:Signal Processing, Computer-Assisted
chemical_list: D005682:Gadolinium
keywords: magnetic resonance imaging; neutron activation analysis; relaxometry of paramagnetic contrast agents; sodium gadolinium fluoride; upconverting nanoparticles