title: Efficacy of pre-surgical axitinib for shrinkage of inferior vena cava thrombus in a patient with advanced renal cell carcinoma.
abstract: The authors present the first case report of pre-surgical axitinib treatment on primary renal tumor and vena cava thrombus. We report the case of a 78-year-old woman with renal cell carcinoma and inferior vena cava tumor thrombus, successfully downstaged with pre-surgical therapy with axitinib. A significant objective response was observed for tumor size and thrombus. After initiation of axitinib therapy, computed tomography showed a decrease, from 57 to 51 mm, in the maximal renal tumor diameter. The tumor thrombus had shortened to 42 mm and had moved to the inferior hepatic vein (Levels 4-3), thereby obviating the need for thoracotomy. The patient finally accepted surgical treatment. Our case was enabled to perform less surgery for advanced renal cell carcinoma with tumor thrombus using axitinib as a pre-surgical therapy.
authors.affiliation: *Graduate School of Medicine, Nagoya University, Showa-ku Tsurumai-chyo 65, Nagoya, Aichi, Japan. sassa@med.nagoya-u.ac.jp.
authors.forename: Naoto
authors.initials: N
authors.lastname: Sassa
authors.forename: Masashi
authors.initials: M
authors.lastname: Kato
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Funahashi
authors.forename: Motohiro
authors.initials: M
authors.lastname: Maeda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.forename: Momokazu
authors.initials: M
authors.lastname: Gotoh
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000077784:Axitinib; D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D005260:Female; D006503:Hepatic Veins; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007191:Indazoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D058990:Molecular Targeted Therapy; D020360:Neoadjuvant Therapy / Q000379:methods; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000187:drug effects*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014682:Vena Cava, Inferior / Q000473:pathology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D007191:Indazoles; D047428:Protein Kinase Inhibitors; D000077784:Axitinib; D040262:Receptors, Vascular Endothelial Growth Factor
keywords: IVC thrombus; axitinib; molecular target agents; pre-surgical; renal cell carcinoma