title: Histologically proven non-alcoholic fatty liver disease and clinically related factors in recipients after liver transplantation.
abstract: Non-alcoholic fatty liver disease (NAFLD) affects a substantial proportion of the world population, and its prevalence has been increasing. The study was aimed at evaluating the prevalence and peri-transplant risk factors for post-liver transplantation (LT) NAFLD. A retrospective review was performed for adult recipients who underwent late protocol biopsy (>1 yr after LT) between August 2010 and December 2012. Hepatic steatosis was reviewed and graded by hepatopathologists, and the peri-transplant factors were analyzed for relationships to histologically proven NAFLD. Total 166 biopsies had been performed in 156 recipients. NAFLD was present in 27.1% at a mean period of 35.4 months between LT and biopsy, moderate and severe steatosis (≥33%) consisted of 28.9%. In multivariate analysis, pre-LT alcoholic cirrhosis (odds ratio [OR] 8.031, p = 0.003), obesity at biopsy (OR 3.873, p = 0.001), and preexisting donor graft steatosis (OR 3.147, p = 0.022) were significant risk factors for post-LT NAFLD. In conclusion, NAFLD represented a considerable portion of recipients, but this prevalence was not higher than those for general population. Three risk factors were significantly related to post-LT NAFLD, and recipients with those factors should be monitored for NAFLD. Furthermore, possible progression to non-alcoholic steatohepatitis (NASH) or fibrosis and metabolic syndrome should be considered in future studies.
authors.affiliation: Department of Surgery, College of Medicine, Seoul National University, Seoul, Republic of Korea; Department of Surgery, Seoul Metropolitan Government, Boramae Medical Center, Seoul National University, Seoul, Republic of Korea.
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Kyoungbun
authors.initials: K
authors.lastname: Lee
authors.forename: Kwang-Woong
authors.initials: KW
authors.lastname: Lee
authors.forename: Nam-Joon
authors.initials: NJ
authors.lastname: Yi
authors.forename: Hae Won
authors.initials: HW
authors.lastname: Lee
authors.forename: Geun
authors.initials: G
authors.lastname: Hong
authors.forename: YoungRok
authors.initials: Y
authors.lastname: Choi
authors.forename: Tae
authors.initials: T
authors.lastname: You
authors.forename: Suk-Won
authors.initials: SW
authors.lastname: Suh
authors.forename: Ja June
authors.initials: JJ
authors.lastname: Jang
authors.forename: Kyung-Suk
authors.initials: KS
authors.lastname: Suh
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D005355:Fibrosis / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D008875:Middle Aged; D065626:Non-alcoholic Fatty Liver Disease / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D016017:Odds Ratio; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D015995:Prevalence; D011379:Prognosis; D012008:Recurrence; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
keywords: biopsy; hepatic steatosis; histology; steatohepatitis; steatosis; transplant