title: The Relationship between ALA16VAL Single Gene Polymorphism and Renal Cell Carcinoma.
abstract: Objectives. The aim of this study was to investigate the association of RCC and Ala16Val polymorphism in Turkish patients with RCC. Materials and Methods. A total of 41 patients with RCC who underwent radical or partial nephrectomy in our clinic and 50 healthy volunteers living in the same geographic area were included in this study. DNA samples from serum of RCC patients and controls were genotyped for MnSOD polymorphism analysis. Genotype ratios and allele frequencies were compared between two groups and odd ratios with 95% confidence intervals were calculated statistically. A P value of <0.05 was considered statistically significant. Results. There was a significant difference in the MnSOD genotype distributions between the RCC patients and the controls in terms of Ala/Ala+Ala/Val and Val/Val genotypes (P = 0.039). The Ala/Ala+Ala/Val genotypes were found significantly suspicious for RCC with an OR of 2.64 (95% CI = 1.06-6.69, P = 0.039). In addition, Ala allele was found significantly suspicious for RCC with an OR of 2.26 (95% CI = 1.24-4.12, P = 0.009). Conclusion. Our study indicated that MnSOD Ala16Val polymorphism may be one of the many genetic factors for renal cancer susceptibility in Turkish patients.
authors.affiliation: Department of Urology, Gaziosmanpasa University Medical Faculty, Tokat 60100, Turkey.
authors.forename: Dogan
authors.initials: D
authors.lastname: Atilgan
authors.affiliation: Department of Urology, Gaziosmanpasa University Medical Faculty, Tokat 60100, Turkey.
authors.forename: Bekir S
authors.initials: BS
authors.lastname: Parlaktas
authors.affiliation: Department of Urology, Gaziosmanpasa University Medical Faculty, Tokat 60100, Turkey.
authors.forename: Nihat
authors.initials: N
authors.lastname: Uluocak
authors.affiliation: Department of Urology, Gaziosmanpasa University Medical Faculty, Tokat 60100, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Kolukcu
authors.affiliation: Department of Urology, Gaziosmanpasa University Medical Faculty, Tokat 60100, Turkey.
authors.forename: Fikret
authors.initials: F
authors.lastname: Erdemir
authors.affiliation: Department of Biochemistry, Gaziosmanpasa University Medical Faculty, Tokat 60100, Turkey.
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ozyurt
authors.affiliation: Department of Biostatistics and Medical Informatics, Medical Faculty, Sakarya University, Turkey.
authors.forename: Unal
authors.initials: U
authors.lastname: Erkorkmaz