title: The Mitotic Exit Network: new turns on old pathways.
abstract: In budding yeast, the Mitotic Exit Network (MEN) is a signaling pathway known to drive cells out of mitosis and promote the faithful division of cells. The MEN triggers inactivation of cyclin-dependent kinase (Cdk1), the master regulator of mitosis, and the onset of cytokinesis after segregation of the daughter nuclei. The current model of the MEN suggests that MEN activity is restricted to late anaphase and coordinated with proper alignment of the spindle pole bodies (SPBs) with the division axis. However, recent evidence suggests that MEN activity may function earlier in mitosis, prompting re-evaluation of the current model. Here we attempt to integrate this recent progress into the current view of mitotic exit.
authors.affiliation: Institute of Biochemistry, Biology Department, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.
authors.forename: Manuel
authors.initials: M
authors.lastname: Hotz
authors.affiliation: Institute of Biochemistry, Biology Department, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland. Electronic address: yves.barral@bc.biol.ethz.ch.
authors.forename: Yves
authors.initials: Y
authors.lastname: Barral
mesh_terms: D016203:CDC2 Protein Kinase / Q000235:genetics*; D020090:Chromosome Segregation / Q000235:genetics; D008938:Mitosis / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics; D008941:Spindle Apparatus / Q000235:genetics*
chemical_list: D016203:CDC2 Protein Kinase
keywords: Hippo pathway; MEN polarity; Mitotic Exit Network; asymmetric cell division; pre-anaphase functions; spindle asymmetry; spindle positioning