title: Non-homologous end joining: emerging themes and unanswered questions.
abstract: Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation induced DNA double strand breaks in human cells. Here, we discuss current insights into the mechanism of NHEJ and the interplay between NHEJ and other pathways for repair of IR-induced DNA damage.
authors.affiliation: Department of Biochemistry & Molecular Biology and Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive, NW, Calgary, Alberta, Canada T2N 4N1.
authors.forename: Sarvan Kumar
authors.initials: SK
authors.lastname: Radhakrishnan
authors.affiliation: Department of Biochemistry & Molecular Biology and Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive, NW, Calgary, Alberta, Canada T2N 4N1.
authors.forename: Nicholas
authors.initials: N
authors.lastname: Jette
authors.affiliation: Department of Biochemistry & Molecular Biology and Southern Alberta Cancer Research Institute, University of Calgary, 3330 Hospital Drive, NW, Calgary, Alberta, Canada T2N 4N1. Electronic address: leesmill@ucalgary.ca.
authors.forename: Susan P
authors.initials: SP
authors.lastname: Lees-Miller
mesh_terms: D002453:Cell Cycle; D053903:DNA Breaks, Double-Stranded / Q000528:radiation effects*; D059766:DNA End-Joining Repair; D045643:DNA Repair Enzymes / Q000378:metabolism; D051747:DNA-Activated Protein Kinase / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism
chemical_list: D009687:Nuclear Proteins; D051747:DNA-Activated Protein Kinase; D045643:DNA Repair Enzymes
keywords: DNA double strand break repair; Ionizing radiation; Non-homologous end joining