title: Gonadal dysfunction in morbidly obese adolescent girls.
abstract: OBJECTIVE
  To describe gonadal dysfunction and evaluate polycystic ovary syndrome (PCOS) and its association with metabolic syndrome (MeS) among girls in a morbidly obese adolescent population.
  
  
  METHODS
  In a cross-sectional study of 174 girls, height, weight, waist circumference, Tanner stage, reproductive hormones, carbohydrate and lipid markers, drug use, and menstrual history were obtained at baseline. Exclusion criteria were menarcheal age <2 years, hormonal contraceptive or metformin use, Tanner stage <4, and incomplete data on PCOS or MeS classification.
  
  
  METHODS
  University medical center outpatient clinic.
  
  
  METHODS
  Ninety-eight girls ages 13-19.6 years, Tanner 5, average body mass index of 46.6 kg/m(2), menarche at 11.4 years, and average menarcheal age of 5 years.
  
  
  METHODS
  None.
  
  
  METHODS
  Polycystic ovary syndrome and MeS.
  
  
  RESULTS
  Ninety-eight girls were divided into four groups: PCOS by National Institutes of Health criteria (PCOSN, n = 24), irregular menses only (n = 25), elevated T (≥55 ng/dL) only (n = 6), and obese controls (n = 43). Metabolic syndrome by modified Cook criteria affected 32 girls or 33% overall: 6 of 24 PCOSN, 7 of 25 irregular menses only, 4 of 6 elevated T only, and 15 of 43 obese controls. Polycystic ovary syndrome by National Institutes of Health criteria and its individual components were not associated with MeS after adjusting for body mass index.
  
  
  CONCLUSIONS
  Unlike obese adults, PCOSN and its individual components were not associated with MeS in the untreated morbidly obese adolescent population.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Columbia University Medical Center, New York, New York.
authors.forename: Vivian
authors.initials: V
authors.lastname: Chin
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Columbia University Medical Center, New York, New York.
authors.forename: Marisa
authors.initials: M
authors.lastname: Censani
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Columbia University Medical Center, New York, New York.
authors.forename: Shulamit
authors.initials: S
authors.lastname: Lerner
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Columbia University Medical Center, New York, New York.
authors.forename: Rushika
authors.initials: R
authors.lastname: Conroy
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Columbia University Medical Center, New York, New York.
authors.forename: Sharon
authors.initials: S
authors.lastname: Oberfield
authors.affiliation: Department of Medicine, Columbia University Medical Center, New York, New York.
authors.forename: Donald
authors.initials: D
authors.lastname: McMahon
authors.affiliation: Department of Surgery, Columbia University Medical Center, New York, New York.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Zitsman
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Columbia University Medical Center, New York, New York. Electronic address: if1@cumc.columbia.edu.
authors.forename: Ilene
authors.initials: I
authors.lastname: Fennoy
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D015897:Comorbidity; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000175:diagnosis / Q000453:epidemiology*; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D009518:New York / Q000453:epidemiology; D009767:Obesity, Morbid / Q000175:diagnosis / Q000453:epidemiology*; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012307:Risk Factors; D017678:Sex Distribution; D055815:Young Adult
keywords: Metabolic syndrome; bariatric surgery; morbid obesity; polycystic ovary syndrome