title: Fluconazole administration leading to anaphylactic shock in a preterm newborn.
abstract: Preterm infants, born with immature innate immunity, are less likely to develop anaphylaxis. Fluconazole prophylaxis during the first six weeks of life decreases invasive candidiasis in very low birth weight infants. Adverse effects of fluconazole are very rare. In this study, we report a newborn (a male, 26 weeks gestation and 900 g birth weight) who developed anaphylaxis after fluconazole administration. Hypotension and erythematous rash were present. We believe this to be the first anaphylaxis case in newborns caused by fluconazole in literature. Clinicians should be aware of the possibility of this potentially fatal adverse effect occurring with intravenous fluconazole.
authors.forename: Esad
authors.initials: E
authors.lastname: Koklu
authors.forename: Salih
authors.initials: S
authors.lastname: Kalay
authors.forename: Selmin
authors.initials: S
authors.lastname: Koklu
authors.forename: Erdal Arvi
authors.initials: EA
authors.lastname: Ariguloglu
mesh_terms: D000707:Anaphylaxis / Q000139:chemically induced*; D000935:Antifungal Agents / Q000009:adverse effects*; D058365:Candidiasis, Invasive / Q000188:drug therapy; D015725:Fluconazole / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole
keywords: anaphylaxis; fluconazole; preterm