title: Estrogen receptor-negative breast ductal carcinoma: clinicopathological features and MIB-1 (Ki-67) proliferative index association.
abstract: Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study.
authors.affiliation: Department of Pathology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia ; Department of Pathology, Sultanah Bahiyah Hospital, Alor Setar, Malaysia.
authors.forename: Noorasmaliza
authors.initials: N
authors.lastname: Mdpaiman
authors.affiliation: Department of Pathology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Siti Aishah
authors.initials: SA
authors.lastname: Md Ali
authors.affiliation: Department of Pathology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Reena
authors.initials: R
authors.lastname: Mdzin
authors.affiliation: Department of Pathology, Sultanah Bahiyah Hospital, Alor Setar, Malaysia.
authors.forename: Meor Zamari
authors.initials: MZ
authors.lastname: Meor Kamal
authors.affiliation: Department of Pathology, Sultanah Bahiyah Hospital, Alor Setar, Malaysia.
authors.forename: Wan Anna
authors.initials: WA
authors.lastname: Md Amin
authors.affiliation: Department of Surgery, Sultanah Bahiyah Hospital, Alor Setar, Malaysia.
authors.forename: Mohan
authors.initials: M
authors.lastname: Nallusamy
authors.affiliation: Department of Pathology, Sultanah Bahiyah Hospital, Alor Setar, Malaysia.
authors.forename: Pavitratha
authors.initials: P
authors.lastname: Puspanathan
authors.affiliation: Department of Surgery, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Rohaizak
authors.initials: R
authors.lastname: Muhammad
authors.affiliation: Department of Epidemiology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Sharifa Ezat
authors.initials: SE
authors.lastname: Wan Puteh
authors.affiliation: Department of Anatomy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
authors.forename: Srijit
authors.initials: S
authors.lastname: Das
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen