title: Effects of viscosity and volume on the patterns of esophageal motility in healthy adults using high-resolution manometry.
abstract: The purpose of this study was to determine the effects of age, sex, body mass index (BMI), viscosity, and volume on esophageal motility using high-resolution manometry (HRM). Manometric studies were performed on 60 asymptomatic volunteers (27 men and 33 women, age: 19-56 years) while in a supine position. Manometric protocol included 10 water swallows (5 cc), 10 jelly swallows (5 cc), and 1 water swallow (20 cc). Evaluation of HRM parameters including length of proximal pressure trough (PPT length), distal latency (DL), contractile front velocity (CFV), distal contractile integral (DCI), and 4-second integrated relaxation pressure (IRP) was performed using MATLAB. Significant differences were noted in median IRP between water 5 cc (median 7.2 mmHg [range 5.5-9.6]), jelly 5 cc (median 6.0 mmHg [range 3.8-8.0]), and water 20 cc {(Median 4.8 mmHg [range 3.3-7.4]), P < 0.01}. DL were significantly different between water 5 cc, jelly 5 cc, and water 20 cc (P < 0.01), and in terms of PPT, proportions of small (2 cm ≤ < 5 cm) and large (5 cm≤) break for jelly 5 cc were significantly higher than those for the water 5 cc swallow (P < 0.05). Furthermore, DCI increased with age for water 5 cc, and a significant negative correlation was noticed between proportions of small break and BMI for water 5 cc. Manometric measurements vary depending on age, BMI, viscosity, and volume. These findings need to be taken into account in the interpretation of manometry results.
authors.affiliation: Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea.
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: P-L
authors.initials: PL
authors.lastname: Rhee
authors.forename: J H
authors.initials: JH
authors.lastname: Park
mesh_terms: D000328:Adult; D000367:Age Factors; D015992:Body Mass Index; D003679:Deglutition / Q000502:physiology*; D060766:Drinking Water; D015154:Esophageal Motility Disorders / Q000175:diagnosis; D004947:Esophagus / Q000502:physiology*; D005260:Female; D005780:Gelatin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D009119:Muscle Contraction; D010528:Peristalsis / Q000502:physiology*; D011312:Pressure; D012737:Sex Factors; D016683:Supine Position; D014783:Viscosity
chemical_list: D060766:Drinking Water; D005780:Gelatin
keywords: contractile front velocity; distal contractile integral; distal latency; high-resolution manometry; integrated relaxation pressure; proximal pressure trough