title: [Interaction of anesthetics and analgesics with tumor cells].
abstract: The results of preclinical and clinical studies indicate that the perioperative period is a vulnerable period for cancer progression and metastasis. The risk of cancer cell dissemination is enhanced by the combination of surgical manipulation and perioperative immunosuppression. Whether the oncological outcome of cancer patients can be influenced by the choice of anesthetic techniques is still a matter of debate. This review summarizes the molecular characteristics of cancer and interaction of anesthetic and analgesic drugs with cancer cells.
authors.affiliation: Klinik für Anästhesiologie, Universitätsklinikum Regensburg, Franz Josef Strauß Allee 11, 93053, Regensburg, Deutschland, anika.bundscherer@ukr.de.
authors.forename: A
authors.initials: A
authors.lastname: Bundscherer
authors.forename: M
authors.initials: M
authors.lastname: Malsy
authors.forename: D
authors.initials: D
authors.lastname: Bitzinger
authors.forename: B M
authors.initials: BM
authors.lastname: Graf
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology* / Q000517:prevention & control; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D000700:Analgesics; D000777:Anesthetics; D007166:Immunosuppressive Agents