title: Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures.
abstract: We measured serum dBPA in non-pregnant and pregnant female rhesus monkeys, fetuses and amniotic fluid. dBPA was administered by a daily oral bolus or sc implantation of Silastic capsules; both resulted in daily average serum unconjugated dBPA concentrations of <1ng/ml. We observed lower serum concentrations of unconjugated dBPA in pregnant females relative to pre-pregnancy values, and generally lower concentrations in fetal serum than in maternal serum. Differences in pharmacokinetics of dBPA were evident between pre-pregnancy, early and late pregnancy, likely reflecting changes in maternal, fetal and placental physiology. The serum ratio of conjugated to unconjugated dBPA after continuous sc release of dBPA was similar to values reported in human biomonitoring studies and markedly lower than with oral administration, suggesting oral bolus exposure is not an appropriate human exposure model. We report elsewhere that there were numerous adverse effects on fetuses exposed to very low serum dBPA in these studies.
authors.affiliation: Division of Biological Sciences, University of Missouri, Columbia, MO, United States. Electronic address: vomsaalF@missouri.edu.
authors.forename: Frederick S
authors.initials: FS
authors.lastname: Vom Saal
authors.affiliation: Department of Obstetrics and Gynecology, University of California, Davis, CA, United States; California National Primate Research Center, University of California, Davis, CA, United States.
authors.forename: Catherine A
authors.initials: CA
authors.lastname: VandeVoort
authors.affiliation: Division of Biological Sciences, University of Missouri, Columbia, MO, United States.
authors.forename: Julia A
authors.initials: JA
authors.lastname: Taylor
authors.affiliation: Department of Biomedical Sciences, University of Missouri, Columbia, MO, United States.
authors.forename: Wade V
authors.initials: WV
authors.lastname: Welshons
authors.affiliation: Université de Toulouse, INPT, ENVT, UPS, UMR1331, F- 31062 Toulouse, France; INRA, UMR1331, Toxalim, Research Centre in Food Toxicology, F- 31027 Toulouse, France.
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Toutain
authors.affiliation: School of Molecular Biosciences, Washington State University, Pullman, WA, United States.
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Hunt
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D002214:Capsules; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D004781:Environmental Exposure; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008253:Macaca mulatta; D008431:Maternal-Fetal Exchange; D010636:Phenols / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D011247:Pregnancy / Q000097:blood / Q000378:metabolism*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D002214:Capsules; D004129:Dimethylpolysiloxanes; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C013830:baysilon; C006780:bisphenol A; D000098826:Bisphenol A Compounds
keywords: Bisphenol A; Fetus; Maternal; Pharmacokinetics; Pregnancy; Rhesus monkey