title: Early-onset seizures are correlated with late-onset seizures in children with arterial ischemic stroke.
abstract: OBJECTIVE
  Early-onset seizures are common in children with arterial ischemic stroke, but the clinical features and effects on the outcome of early-onset seizures have been less studied in children.
  
  
  METHODS
  Children aged 1 month to 18 years presenting with first-time and image-confirmed arterial ischemic stroke were identified for analysis.
  
  
  RESULTS
  A total of 78 survivors of arterial ischemic stroke were enrolled. Twenty (25.6%) had early-onset seizures, and 90% were initial presentation. Younger children (mean, 3.4±3.9 versus 9.0±6.2 years; P<0.001) and cortical involvement (5% versus 63.8%; P=0.01) are more likely to have early-onset seizures. Thirteen of 20 survivors with early-onset seizures had late-onset seizures after the acute stage, and 12 of them were diagnosed as poststroke epilepsy.
  
  
  CONCLUSIONS
  Early-onset seizures occurred in 25.6% of children with arterial ischemic stroke. Younger age and cortical involvement were risk factors for early-onset seizures. Sixty-five percent of children with early-onset seizures had late-onset seizures after the acute stage.
authors.affiliation: From the Department of Pediatrics, En Chu Kong Hospital, Taipei, Taiwan (C.-J.H.); and Departments of Pediatrics (W.-C.W., W.-T.L.) and Diagnostic Imaging (S.S.-F.P.), National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: Chen-Jui
authors.initials: CJ
authors.lastname: Hsu
authors.forename: Wen-Chin
authors.initials: WC
authors.lastname: Weng
authors.forename: Steven Shinn-Feng
authors.initials: SS
authors.lastname: Peng
authors.forename: Wang-Tso
authors.initials: WT
authors.lastname: Lee
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D017677:Age Distribution; D017668:Age of Onset; D002545:Brain Ischemia / Q000150:complications* / Q000453:epidemiology* / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000453:epidemiology* / Q000401:mortality; D017741:Survivors / Q000706:statistics & numerical data
keywords: children; epilepsy; seizures; stroke