title: Are we really closer to improving the diagnostic sensitivity in ALS patients with Awaji criteria?
abstract: The Awaji criteria, recently introduced to increase diagnosis sensitivity in amyotrophic lateral sclerosis (ALS), equate the diagnostic significance of neurogenic electrophysiological changes to clinical signs of lower motor neuron dysfunction. They also increase the electrophysiological significance of fasciculation potentials (FPs). The aim of our study was to analyse whether the new parameters improve diagnostic sensitivity in ALS patients primarily diagnosed with the El Escorial criteria. Medical and electrophysiological records of 135 consecutive patients with ALS and 25 patients with progressive muscular atrophy (PMA) who underwent electrophysiological examination of at least three anatomical regions were analysed retrospectively. Results showed that implementation of the Awaji criteria increased the level of ALS diagnosis sensitivity in 5.9% of cases - 1.5% due to the new role of FPs potentials and 4.4% because of equalization of clinical and EMG findings. In 4% of patients the ALS diagnosis was, however, changed from laboratory-supported probable ALS to possible ALS. In conclusion, our study confirms that Awaji modifications are able to improve the diagnostic certainty in a few ALS cases. Although the new approach to FPs markedly increases the number of involved muscles, it only slightly raises the number of involved regions.
authors.affiliation: Department of Neurology, Medical University of Warsaw , Warsaw , Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Gawel
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kuzma-Kozakiewicz
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Szmidt-Salkowska
authors.forename: Anna
authors.initials: A
authors.lastname: Kamińska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis*; D004568:Electrodiagnosis / Q000379:methods* / Q000592:standards*; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology*; D009460:Neurologic Examination; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D055815:Young Adult
keywords: EMG; clinical trials; neurophysiology