title: Electrophilic alkynylation of ketones using hypervalent iodine.
abstract: A new method for the electrophilic α-alkynylation of ketones was developed using hypervalent iodine under mild and metal-free conditions. Carbonyl compounds containing an α-acetylene group were obtained in good to excellent yields for several ketones using 1-[(trimethylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TMS-EBX) as an alkynylation agent in the presence of t-BuOK and TBAF in THF as solvent. Under the same conditions, an aldehyde was alkynylated.
authors.affiliation: Instituto de Química, Universidade de São Paulo, CP 26077, CEP 05513-970, São Paulo - SP, Brazil. luizfsjr@iq.usp.br.
authors.forename: Aline
authors.initials: A
authors.lastname: Utaka
authors.forename: Livia N
authors.initials: LN
authors.lastname: Cavalcanti
authors.forename: Luiz F
authors.initials: LF
authors.lastname: Silva