title: Absence of association between atherosclerotic cerebral infarction and TNFSF4/TNFRSF4 single nucleotide polymorphisms rs1234313, rs1234314 and rs17568 in a Chinese population.
abstract: OBJECTIVE
  To clarify the association between atherosclerotic cerebral infarction (ACI) and the single nucleotide polymorphisms (SNP) rs1234313 and rs1234314 (in TNFSF4) and rs17568 (in TNFRSF4).
  
  
  METHODS
  Genomic DNA was extracted from peripheral blood of patients with ACI and healthy control subjects. The presence of carotid plaque was determined. Rs1234313, rs1234314 and rs17568 were characterized via SNP genotyping assay and verified by DNA sequencing.
  
  
  RESULTS
  Genotype distributions were in Hardy-Weinberg equilibrium. There were no significant differences in the allele and genotype distributions of rs1234313, rs1234314 and rs17568 between patients with ACI (n = 450) and healthy control subjects (n = 378), or between patients with ACI and carotid plaque (n = 342) and controls.
  
  
  CONCLUSIONS
  There were no significant associations between rs1234313, rs1234314 and rs17568 and ACI risk in a Han Chinese population.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
authors.forename: Qi-Dong
authors.initials: QD
authors.lastname: Yang
authors.forename: Xing-Lin
authors.initials: XL
authors.lastname: Tan
authors.forename: Jie
authors.initials: J
authors.lastname: Feng
authors.forename: Tao
authors.initials: T
authors.lastname: Tang
authors.forename: Jian
authors.initials: J
authors.lastname: Xia
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Huang
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: Bai
authors.forename: Yun-Hai
authors.initials: YH
authors.lastname: Liu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D016893:Carotid Stenosis; D002544:Cerebral Infarction / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D053278:OX40 Ligand / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D053262:Receptors, OX40 / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D053278:OX40 Ligand; D053262:Receptors, OX40; C505716:TNFRSF4 protein, human; C089251:TNFSF4 protein, human
keywords: Atherosclerosis; SNP; TNFRSF4; TNFSF4; cerebral infarction