title: Nitric oxide and antioxidant enzyme levels in blood of respiratory distress syndrome--Egyptian preterms and their mothers.
abstract: BACKGROUND
  The mechanisms of tissue injury in respiratory distress syndrome (RDS) have not been completely elucidated but the involvement of oxidative damage due to reactive oxygen species (ROS) is important in the pathogenesis of preterm labor and RDS.
  
  
  OBJECTIVE
  To assess the oxidative status in preterms with and without RDS and in their mothers.
  
  
  METHODS
  Measuring and comparing concentrations of serum nitric oxide (NO), and erythrocytic activities of some antioxidant enzymes in blood of 20 preterms with RDS and 20 preterms without and their mothers, respectively.
  
  
  RESULTS
  Our results confirm significant elevation of mean levels of serum NO and reduced mean levels of erythrocytic activities of antioxidant enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT), in RDS preterms and their mothers compared with controls and their mothers. A significant positive correlations were found between maternal and preterm serum NO (r=0.3 & 0.6) and erythrocytic activity of SOD (r=0.5 & 0.4) for RDS and control groups, respectively. In addition, a significant negative correlations were found between NO and SOD in all groups.
  
  
  CONCLUSIONS
  The existence of oxygen metabolites and lipid peroxidation was significantly more obvious in RDS preterms and in their mothers than those without.
authors.affiliation: Department of Pediatrics .
authors.forename: Hosny M A
authors.initials: HM
authors.lastname: El-Masry
authors.forename: Ahmed A M
authors.initials: AA
authors.lastname: Nasr
authors.forename: Ashraf M
authors.initials: AM
authors.lastname: Al Kabeer
authors.forename: H H
authors.initials: HH
authors.lastname: Amin
authors.forename: Hussein M H
authors.initials: HM
authors.lastname: Eldeeb
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007234:Infant, Premature; D015227:Lipid Peroxidation; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood*; D013482:Superoxide Dismutase / Q000378:metabolism; D055815:Young Adult
chemical_list: D000975:Antioxidants; D009569:Nitric Oxide; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
keywords: Antioxidant enzymes; RDS; nitric oxide; oxidative stress; preterm labor