title: Strategies towards the synthesis of calyciphylline A-type Daphniphyllum alkaloids.
abstract: The Daphniphyllum alkaloids are a diverse family of natural products rich in number and structural diversity that have been known for many decades. However, the structurally unique subclass of calyciphylline A-type alkaloids has only recently been discovered and is relatively unexplored. Several noteworthy core syntheses and the development of a wide range of novel synthetic strategies have been achieved. This includes strategies based on intramolecular Michael addition, Pd-catalysis, cycloaddition, and Mannich-type reactions. This review will provide an overview of these synthetic studies.
authors.affiliation: The Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. darren.dixon@chem.ox.ac.uk.
authors.forename: Baldip
authors.initials: B
authors.lastname: Kang
authors.forename: Pavol
authors.initials: P
authors.lastname: Jakubec
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Dixon
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D031995:Saxifragaceae / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000470:Alkaloids; D001688:Biological Products; D011083:Polycyclic Compounds; C479143:calyciphylline A