title: Investigation of recurrence risk in laryngeal cancer following laser surgery.
abstract: BACKGROUND
  The general prognostic factors in larynx tumors are believed to be tumor stage, anatomical location, histological differentiation and the presence of neck metastasis. Effects of tumor invasion to sub-regions of larynx (anterior commissure, ventricle, subglottic space) and over-expression of p53, c-erb-B2 and Ki67 detected immunohistochemically on development of recurrence in patients were investigated in this study.
  
  
  METHODS
  Twenty patients (Group 1) in whom recurrence had developed and 20 others (Group 2) without recurrence during follow-up were included in this study.
  
  
  RESULTS
  Both the anterior commissure and ventricle involvements were found to be more frequent in patients with recurrence. But statistically significant difference was detected with only ventricular involvement (p=0.025). After Immunohistochemical evaluation none of the 3 immunohistochemical parameters were found to be higher in the recurrence group and not any of them showed a statistically significant difference between two groups.
  
  
  CONCLUSIONS
  Only ventricle involvement may be a predictor factor for recurrence.
authors.affiliation: Department of Otolaryngology, Lütfiye Nuri Burat State Hospital, Istanbul, Turkey.
authors.forename: Erdinç
authors.initials: E
authors.lastname: Cekiç
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors.forename: Ozgür
authors.initials: O
authors.lastname: Sürmelioǧlu
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors.forename: Ozgür
authors.initials: O
authors.lastname: Tarkan
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Ozdemir
authors.affiliation: Department of Pathology, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Uǧuz
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Çukurova University, Adana, Turkey.
authors.forename: Mete
authors.initials: M
authors.lastname: Kıroǧlu
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000096:biosynthesis; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D000077195:Squamous Cell Carcinoma of Head and Neck
chemical_list: D014408:Biomarkers, Tumor
keywords: Ki67; Larynx cancer; c-erb-B2; p53; recurrence