title: Oxidative stress response pathways: Fission yeast as archetype.
abstract: Schizosaccharomyces pombe is a popular model eukaryotic organism to study diverse aspects of mammalian biology, including responses to cellular stress triggered by redox imbalances within its compartments. The review considers the current knowledge on the signaling pathways that govern the transcriptional response of fission yeast cells to elevated levels of hydrogen peroxide. Particular attention is paid to the mechanisms that yeast cells employ to promote cell survival in conditions of intermediate and acute oxidative stress. The role of the Sty1/Spc1/Phh1 mitogen-activated protein kinase in regulating gene expression at multiple levels is discussed in detail.
authors.affiliation: a Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark , Lyngby , Denmark.
authors.forename: Manos A
authors.initials: MA
authors.lastname: Papadakis
authors.affiliation: a Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark , Lyngby , Denmark.
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Workman
mesh_terms: D002470:Cell Survival / Q000502:physiology; D015966:Gene Expression Regulation, Fungal; D006861:Hydrogen Peroxide / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D012568:Schizosaccharomyces / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D029702:Schizosaccharomyces pombe Proteins; D006861:Hydrogen Peroxide; D020928:Mitogen-Activated Protein Kinases; C524689:Spc1 protein, S pombe; C095409:sty1 protein, S pombe
keywords: Adaptation; gene regulation; hydrogen peroxide; redox signaling; survival