title: [Impact of continuous blood purification on T cell subsets in children with severe sepsis].
abstract: OBJECTIVE
  To investigate the impact of continuous blood purification (CBP) on T-cell subsets and prognosis in children with severe sepsis.
  
  
  METHODS
  A total of 42 children with severe sepsis were randomly divided into a control group (n=22) and a CBP group (n=20). The patients in the control group received conventional treatment, while those in the CBP group underwent continuous veno-venous hemofiltration daily 12-24 hours for 3 days besides conventional treatment. Changes in clinical variables and in peripheral blood regulatory T cell subsets were assessed 3 and 7 days after treatment.
  
  
  RESULTS
  The pediatric intensive care unit length of stay and duration of mechanical ventilation were significantly shortened and the 28-day mortality rate was significantly lower in the CPB treatment group as compared with the control group (P<0.05). In the CBP treatment group, the percentage of CD3(+), CD4(+), CD8(+) T cell populations and PCIS scores were significantly higher at 3 and 7 days after treatment than before treatment (P<0.05). At 7 days after treatment, the percentage of CD3(+), CD4(+), CD8(+) T cell populations, CD4(+)/CD8(+) ratio and PCIS scores were significantly higher in the CBP group than in the control group (P<0.05).
  
  
  CONCLUSIONS
  The CBP treatment may counteract the suppression of immune function and thus improve prognosis in children with severe sepsis.
authors.affiliation: Intensive Care Unit, Hunan Province Children's Hospital, Changsha 410007, China. xzhh2010@163.com.
authors.forename: Yuan-Hong
authors.initials: YH
authors.lastname: Yuan
authors.forename: Yuan-Hong
authors.initials: YH
authors.lastname: Yuan
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Xiao
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Jiang-Hua
authors.initials: JH
authors.lastname: Fan
authors.forename: Xin-Ping
authors.initials: XP
authors.lastname: Zhang
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Lu
authors.forename: Zhi-Yue
authors.initials: ZY
authors.lastname: Xu
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Luo
mesh_terms: D016516:CD4-CD8 Ratio; D002675:Child, Preschool; D005260:Female; D006440:Hemofiltration; D006801:Humans; D008297:Male; D018805:Sepsis / Q000276:immunology / Q000628:therapy*; D016176:T-Lymphocyte Subsets / Q000276:immunology*