title: Comparison of preoperative endometrial biopsy grade and final pathologic diagnosis in patients with endometrioid endometrial cancer.
abstract: OBJECTIVE
  To compare preoperative grading in endometrioid endometrial cancer with the final pathologic assessment of the hysterectomy specimen. The second objective of the study was to determine a high risk group who will be upgraded in the postoperative evaluation.
  
  
  METHODS
  A total of 335 patients with endometrioid endometrial cancer were retrospectively reviewed between June 2000 and January 2011. All pathology results were pre- and postoperatively reviewed at two institutions, and all patients underwent surgical therapy. Sensitivity, specificity, positive and negative predictive values and accuracy rates were calculated for all grades in the preoperative assessment.
  
  
  RESULTS
  The mean age of the patients was 56.2±9.6 and the vast majority of the patients were postmenopausal (n=239, 71.3%). FIGO grade was determined to be greater in 75 patients in the final hysterectomy specimen. Fifty-five (32.9%) of the patients with preoperative grade 1 were found to be grade 2 and 3.6% of them were upgraded to grade 3. Fourteen of the patients with grade 2 (11.4%) were found to be grade 3. The accuracy rates of the preoperative grade assessment with endometrial sampling were 75.5%, 66.2% and 88.3% for grades 1, 2 and 3, respectively. There were no statistically significant differences in the preoperative demographic characteristics between patients with or without upgraded tumors.
  
  
  CONCLUSIONS
  A high percentage of preoperatively diagnosed grade 1 tumors were upgraded in the postoperative evaluation. The patients who would have been upgraded after hysterectomy could not have been predicted preoperatively using the characteristic features.
authors.affiliation: Department of Gynecology and Obstetrics, Haseki Teaching and Research Hospital, İstanbul, Turkey.
authors.forename: Behiye Pınar Çilesiz
authors.initials: BP
authors.lastname: Göksedef
authors.affiliation: Department of Gynecology and Obstetrics, İstanbul Kanuni Sultan Süleyman Research and Teacing Hospital, İstanbul, Turkey.
authors.forename: Ozgür
authors.initials: O
authors.lastname: Akbayır
authors.affiliation: Department of Gynecology and Obstetrics, İstanbul Kanuni Sultan Süleyman Research and Teacing Hospital, İstanbul, Turkey.
authors.forename: Aytül
authors.initials: A
authors.lastname: Corbacıoğlu
authors.affiliation: Department of Gynecology and Obstetrics, İstanbul Kanuni Sultan Süleyman Research and Teacing Hospital, İstanbul, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Güraslan
authors.affiliation: Department of Gynecology and Obstetrics, İstanbul Kanuni Sultan Süleyman Research and Teacing Hospital, İstanbul, Turkey.
authors.forename: Fatmagül
authors.initials: F
authors.lastname: Sencan
authors.affiliation: Department of Gynecology and Obstetrics, Antalya Teaching and Research Hospital, Antalya, Turkey.
authors.forename: Onur
authors.initials: O
authors.lastname: Erol
authors.affiliation: Department of Gynecology and Obstetrics, Haseki Teaching and Research Hospital, İstanbul, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Cetin
keywords: Endometrial cancer; biopsy; grade; postoperative evaluation; preoperative evaluation