title: Effect of GABAB receptor antagonist (CGP35348) on learning and memory in albino mice.
abstract: The present study was designed to demonstrate the potential effect of CGP 35348 (GABAB receptor antagonist) on the learning, memory formation, and neuromuscular coordination in albino mouse. Mice were intrapertoneally injected with 1 mg CGP 35348/mL of distilled water/Kg body weight, while the control animals were injected with equal volume of saline solution. A battery of neurological tests was applied following the intrapertoneal injections. Results of rota rod indicated that CGP 35348 had no effect on neuromuscular coordination in both male (P=0.528) and female (P=0.125) albino mice. CGP 35348 treated females demonstrated poor exploratory behavior during open filed for several parameters (time mobile (P=0.04), time immobile (P=0.04), rotations (P=0.04), and anticlockwise rotations (P=0.038)). The results for Morris water maze (MWM) retention phase indicated that CGP 35348 treated male mice took shorter latency to reach the hidden platform (P=0.04) than control indicating improved memory. This observation was complemented by the swim strategies used by mice during training days in MWM as CGP 35348 treated males used more direct and focal approach to reach the platform as the training proceeded.
authors.affiliation: Zoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, Pakistan.
authors.forename: Quratulane
authors.initials: Q
authors.lastname: Gillani
authors.affiliation: Zoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, Pakistan.
authors.forename: Shahid
authors.initials: S
authors.lastname: Iqbal
authors.affiliation: Zoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, Pakistan.
authors.forename: Fatima
authors.initials: F
authors.lastname: Arfa
authors.affiliation: Zoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, Pakistan.
authors.forename: Saba
authors.initials: S
authors.lastname: Khakwani
authors.affiliation: Department of Statistics, Bahauddin Zakariya University, Multan 60800, Pakistan.
authors.forename: Atif
authors.initials: A
authors.lastname: Akbar
authors.affiliation: Department of Zoology, Quaid-I-Azam Campus, Punjab University, Lahore 54000, Pakistan.
authors.forename: Asmat
authors.initials: A
authors.lastname: Ullah
authors.affiliation: Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan 60800, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
authors.affiliation: Zoology Division, Institute of Pure and Applied Biology, Bahauddin Zakariya University, Multan 60800, Pakistan.
authors.forename: Furhan
authors.identifier: 0000-0003-4996-0152
authors.initials: F
authors.lastname: Iqbal
mesh_terms: D000818:Animals; D005260:Female; D058788:GABA-B Receptor Antagonists / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects* / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D009943:Organophosphorus Compounds / Q000494:pharmacology*
chemical_list: D058788:GABA-B Receptor Antagonists; D009943:Organophosphorus Compounds; C066430:CGP 35348