title: Manipulating nuclear architecture.
abstract: The eukaryotic genome is highly organized in the nucleus. Genes can be localized to specific nuclear compartments in a manner reflecting their activity. A plethora of recent reports has described multiple levels of chromosomal folding that can be related to gene-specific expression states. Here we discuss studies designed to probe the causal impact of genome organization on gene expression. The picture that emerges is that of a reciprocal relationship in which nuclear organization is not only shaped by gene expression states but also directly influences them.
authors.affiliation: Transcription Imaging Consortium, Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, United States.
authors.forename: Wulan
authors.initials: W
authors.lastname: Deng
authors.affiliation: Division of Hematology, The Children's Hospital of Philadelphia, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, United States. Electronic address: blobel@email.chop.edu.
authors.forename: Gerd A
authors.initials: GA
authors.lastname: Blobel
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D002843:Chromatin / Q000737:chemistry / Q000235:genetics*; D015870:Gene Expression; D016678:Genome; D006801:Humans
chemical_list: D002843:Chromatin