title: Enzyme-promoted regioselective coupling oligomerization of isorhapontigenin towards the first synthesis of (±)-gnetulin.
abstract: We report the first synthesis of a natural (±)-gnetulin and an unnatural analogue of (±)-gnemonol M by using the regioselective oxidative coupling reactions of 5-tert-butyl-isorhapontigenin as the key step. Both the effects of different enzyme-catalyzed systems on the structures of coupling products and structural transformations of coupling products in the presence of several Lewis acids were systematically investigated.
authors.affiliation: School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, 730070, China. liwl@mail.lzjtu.cn.
authors.forename: Wenling
authors.initials: W
authors.lastname: Li
authors.forename: Shixia
authors.initials: S
authors.lastname: Yang
authors.forename: Teng
authors.initials: T
authors.lastname: Lv
authors.forename: Yadong
authors.initials: Y
authors.lastname: Yang
mesh_terms: D055162:Biocatalysis; D006735:Horseradish Peroxidase / Q000737:chemistry / Q000378:metabolism*; D007189:Indans / Q000737:chemistry / Q000378:metabolism*; D042845:Laccase / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D012118:Resorcinols / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013267:Stilbenes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D007189:Indans; D012118:Resorcinols; D013267:Stilbenes; C432307:isorhapontigenin; D042845:Laccase; D006735:Horseradish Peroxidase