title: Brain dopamine transporter binding and glucose metabolism in progressive supranuclear palsy-like creutzfeldt-jakob disease.
abstract: Here, we present a patient with Creutzfeldt-Jakob disease (CJD) who developed initial symptoms mimicking progressive supranuclear palsy (PSP). Before the development of typical CJD symptoms, functional imaging supported a diagnosis of PSP when [(123)I]-FP-CIT-SPECT showed a defect in striatal dopamine transporter binding, while [(18)F]-fluorodeoxyglucose PET showed cortical hypometabolism suggestive of Lewy body dementia. However, the postmortem neuropathological examination was indicative of CJD only, without tau protein or Lewy body findings. This case demonstrates that CJD should be taken into account in rapidly progressing atypical cases of parkinsonism, even when functional imaging supports a diagnosis of a movement disorder.
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland ; Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Eero
authors.initials: E
authors.lastname: Rissanen
authors.affiliation: Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland ; Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Valtteri
authors.initials: V
authors.lastname: Kaasinen
authors.affiliation: Neuroradiology Department, Turku University Hospital, Medical Imaging Centre of Southwest Finland, Turku, Finland.
authors.forename: Pirkko
authors.initials: P
authors.lastname: Sonninen
authors.affiliation: Department of Pathology, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Matias
authors.initials: M
authors.lastname: Röyttä
authors.affiliation: Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Turku, Finland.
authors.forename: Markku
authors.initials: M
authors.lastname: Päivärinta
keywords: Creutzfeldt-Jakob disease; MRI; PET; Progressive supranuclear palsy