title: CD11b+ DCs rediscovered: implications for vaccination.
abstract: Dendritic cells (DCs) are potent antigen sensing and presenting cells, able to both initiate and orchestrate complex immune responses. DCs are optimally equipped to recognize pathogens, as well as self-antigens and vaccine components, and instruct the type, magnitude and specificity of the ensuing immunity. However, the DC population is remarkably heterogeneous and consists of multiple subsets with different ontogeny, differentiation and functional specializations. Therefore, a deeper understanding of DC subset biology is fundamental for the development and implementation of innovative vaccination strategies.
authors.affiliation: Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Biopolis, 138648, Singapore.
authors.forename: Florent
authors.initials: F
authors.lastname: Ginhoux
authors.forename: Andreas
authors.initials: A
authors.lastname: Schlitzer
mesh_terms: D039481:CD11b Antigen / Q000032:analysis*; D003713:Dendritic Cells / Q000737:chemistry* / Q000276:immunology*; D006801:Humans; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
chemical_list: D039481:CD11b Antigen; C509295:ITGAM protein, human; D014612:Vaccines