title: Novel t(2;12)(q31;p13) in a case of pediatric T-cell acute lymphoblastic leukemia.
abstract: BACKGROUND
  The role of ETV6 in B-cell acute lymphoblastic leukemia (ALL) has been extensively studied, whereas only rare cases of ETV6 involvement in pediatric T-cell ALL have been described.
  
  
  METHODS
  We report a case of T-cell ALL in a 13-year-old boy with t(2;12)(q31;p13) involving ETV6, resulting in the relocation of the ETV6 from 12p13 to 2q31 locus that harbors the class 1 homeobox gene (HOX) cluster D, which is expressed during the early stages of T-cell development.
  
  
  CONCLUSIONS
  We report a novel translocation in T-cell ALL highlighting the involvement of ETV6 and potentially the HOXD gene cluster in a case of T-cell ALL.
authors.affiliation: Departments of *Cytogenetics †Pediatric Hematology ‡Lab Hematology §Clinical Hematology, Tata Medical Center, Kolkata, India.
authors.forename: Mayur
authors.initials: M
authors.lastname: Parihar
authors.forename: Anurag
authors.initials: A
authors.lastname: Gupta
authors.forename: Arun S
authors.initials: AS
authors.lastname: Remani
authors.forename: Arpita
authors.initials: A
authors.lastname: Bhattacharyya
authors.forename: Deepak K
authors.initials: DK
authors.lastname: Mishra
authors.forename: Mammen
authors.initials: M
authors.lastname: Chandy
mesh_terms: D000293:Adolescent; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2 / Q000235:genetics*; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D005434:Flow Cytometry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D014178:Translocation, Genetic / Q000235:genetics*; D000097764:ETS Translocation Variant 6 Protein
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit; D015514:Oncogene Proteins, Fusion; C102421:TEL-AML1 fusion protein; D000097764:ETS Translocation Variant 6 Protein