title: Association between ACE I/D polymorphism and pulmonary tuberculosis in Chinese population.
abstract: Tuberculosis (TB) remains a global public health problem worldwide. The objective of the current study is to investigate the possible association of ACE I/D polymorphism with pulmonary TB (PTB) for Chinese in Sichuan province. Three hundred eighty-six PTB patients and 398 healthy controls were genotyped to analyze the I/D polymorphism using PCR method. The results showed that the I/D polymorphism was not associated with susceptibility to PTB for Chinese (D vs. I: OR 1.03, 95% CI 0.84-1.26, and P=0.77; DD vs. II+DI: OR 1.09, 95% CI 0.73-1.63, and P=0.68; DD+DI vs. II: OR 1.00, 95% CI 0.74-1.33, and P=0.98). The I/D polymorphism in the ACE gene may not a risk factor for PTB in Chinese.
authors.affiliation: Department of Respiratory Medicine, West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, 610041, Sichuan, China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Li
authors.forename: Zhangjun
authors.initials: Z
authors.lastname: Wu
authors.forename: Hong
authors.initials: H
authors.lastname: Fan
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A