title: Association of lichen planopilaris with thyroid disease: a retrospective case-control study.
abstract: BACKGROUND
  Studies on the precise causes and comorbidities seen with lichen planopilaris (LPP) are limited.
  
  
  OBJECTIVE
  We sought to determine the prevalence of thyroid diseases in patients with LPP.
  
  
  METHODS
  Medical records of 166 patients with LPP and 81 age- and gender-matched control subjects seen in the Department of Dermatology at the Cleveland Clinic Foundation in Ohio between 2000 and 2013 were reviewed.
  
  
  RESULTS
  A diagnosis of thyroid disease was present in 34% (n = 57) of the 166 patients with LPP, and in 11% (n = 9) of the control subjects (P = .0001). When confined to hypothyroidism only, this disease was found in 29% (n = 48) of the patients with LPP and 9% (n = 7) of the control subjects (P = .0003).
  
  
  CONCLUSIONS
  This study was limited by being retrospective.
  
  
  CONCLUSIONS
  In our patients, LPP was associated with thyroid disease, especially hypothyroidism.
authors.affiliation: Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, Ohio. Electronic address: natashadermatology@gmail.com.
authors.forename: Natasha
authors.initials: N
authors.lastname: Atanaskova Mesinkovska
authors.affiliation: Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Nikoleta
authors.initials: N
authors.lastname: Brankov
authors.affiliation: Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Melissa
authors.initials: M
authors.lastname: Piliang
authors.affiliation: Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Angela
authors.initials: A
authors.lastname: Kyei
authors.affiliation: Department of Dermatology and Dermatopathology, Cleveland Clinic, Cleveland, Ohio.
authors.forename: Wilma F
authors.initials: WF
authors.lastname: Bergfeld
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000505:Alopecia / Q000453:epidemiology; D016022:Case-Control Studies; D015897:Comorbidity; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology; D008010:Lichen Planus / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000453:epidemiology*; D055815:Young Adult
keywords: alopecia; cicatricial alopecia; hypothyroidism; lichen planopilaris; thyroid disease; thyroiditis