title: [Research of the relationship of ubiquinone and beclin-1 and liver mitochondria].
abstract: OBJECTIVE
  To study whether CO-Q10 can protect liver injury caused by acute on chronic liver failure (ACLF) by autophagy.
  
  
  METHODS
  Rats were separated into three groups: control group, acute on chronic liver failure (ACLF) and intervenient group, liver tissues were observed by optical microscopy and electron microscopy. The levels of Beclin-1 expression were determined by real-time PCR. And Western Blot.
  
  
  RESULTS
  Areas of necrosis detected in intervenient group were alleviated than in ACLF significantly. Most mitochondrias had been degradated in ACLF group while alive in intervenient group. Real-time PCR and Western Blot revealed level of beclin-1 in ACLF was lower than control and intervenient group.
  
  
  CONCLUSIONS
  Intervenient group may ameliorate rat liver injury by promoting autophagy.
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Xie
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Yue-Ke
authors.initials: YK
authors.lastname: Zhu
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Liu
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Liu
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Jia
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Ke-Fei
authors.initials: KF
authors.lastname: Wang
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: De-Xi
authors.initials: DX
authors.lastname: Chen
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing Institute of Liver Disease, Beijing 100069, China.
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Meng
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism*; D001343:Autophagy; D000071186:Beclin-1; D006801:Humans; D017114:Liver Failure, Acute / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D000071186:Beclin-1; C512829:Becn1 protein, rat; D014451:Ubiquinone; C024989:coenzyme Q10