title: nab-Paclitaxel in Combination with Carboplatin for a Previously Treated Thymic Carcinoma.
abstract: We present the case of a 40-year-old man with previously treated thymic carcinoma, complaining of gradually worsening back pain. Computed tomography scans of the chest showed multiple pleural disseminated nodules with a pleural effusion in the right thorax. The patient was treated with carboplatin on day 1 plus nab-paclitaxel on day 1 and 8 in cycles repeated every 4 weeks. Objective tumor shrinkage was observed after 4 cycles of this regimen. In addition, the elevated serum cytokeratin 19 fragment level decreased, and the patient's back pain was relieved without any analgesics. Although he experienced grade 4 neutropenia and granulocyte colony-stimulating factor (G-CSF) injection, the severity of thrombocytopenia and nonhematological toxicities such as reversible neuropathy did not exceed grade 1 during the treatment. To our knowledge, this is the first report to demonstrate the efficacy of combination chemotherapy consisting of carboplatin and nab-paclitaxel against thymic carcinoma. This case report suggests that nab-paclitaxel in combination with carboplatin can be a favorable chemotherapy regimen for advanced thymic carcinoma.
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Go
authors.initials: G
authors.lastname: Makimoto
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Keiichi
authors.initials: K
authors.lastname: Fujiwara
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Watanabe
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Kameyama
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Mizuho
authors.initials: M
authors.lastname: Matsushita
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Kammei
authors.initials: K
authors.lastname: Rai
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Sato
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Yonei
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Sato
authors.affiliation: Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center, Okayama, Japan.
authors.forename: Takuo
authors.initials: T
authors.lastname: Shibayama
keywords: Carboplatin; Chemotherapy; Thymic carcinoma; nab-Paclitaxel