title: Navigating through the maze of TLR2 mediated signaling network for better mycobacterium infection control.
abstract: Toll-like receptor 2 (TLR2), a member of pattern recognition receptors (PRRs) abundant on macrophages, dendritic cells (DCs) and respiratory epithelial cells lining the lung, plays critical role in host immune response against Mycobacterium tuberculosis (MTB) infection. TLR2-mediated elimination of MTB involves multiple pathways such as promoting DCs maturation, generating biased Th1, Th2, Th17 type response, regulating the macrophage activation and cytokine secretion. MTB can also hijack the TLR2 signaling to subvert the host immunity by dampening the macrophages response to IFN-γ, suppressing the processing and presentation of antigens. This review summarizes the intricate network of TLR2-mediated signaling and Mycobacteria effectors involved in MTB-host interaction with an aim to find better target for improved tuberculosis control, especially the host-derived therapy targets. TLR2 agonists with potential to be included in novel tuberculosis vaccines are also discussed.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Xiaowen
authors.initials: X
authors.lastname: Yu
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zeng
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, China. Electronic address: georgex@swu.edu.cn.
authors.forename: Jianping
authors.initials: J
authors.lastname: Xie
mesh_terms: D003713:Dendritic Cells / Q000276:immunology / Q000382:microbiology; D054884:Host-Pathogen Interactions / Q000235:genetics; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000472:pathogenicity; D015398:Signal Transduction / Q000235:genetics; D051195:Toll-Like Receptor 2 / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology / Q000382:microbiology
chemical_list: C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2
keywords: Host immune response; Mycobacterium tuberculosis; TLR2