title: Preliminary examination of glucagon-like peptide-1 levels in women with purging disorder and bulimia nervosa.
abstract: OBJECTIVE
  This study examined pre- and postprandial glucagon-like peptide 1 (GLP-1) levels in women with bulimia nervosa (BN), purging disorder (PD), and non-eating disorder control women to better understand whether alterations in satiation-related hormones in BN may be linked to binge-eating episodes or other altered ingestive behaviors.
  
  
  METHODS
  Participants included women with BN (n = 19), PD (n = 14), or controls (n = 14). Participants provided subjective ratings for hunger and fullness and plasma samples before and after consumption of a standardized test meal.
  
  
  RESULTS
  As expected, GLP-1 levels increased significantly following test meal consumption; however, participants with BN displayed significantly lower GLP-1 levels compared to PD and control participants both before and after consumption of the test meal. There were no significant differences between PD and control participants in GLP-1 levels, but individuals with PD displayed significantly higher levels of fullness throughout the test meal as compared to both control and BN participants.
  
  
  CONCLUSIONS
  Our findings provide preliminary evidence that reduced GLP-1 levels in individuals with BN may be associated with binge-eating episodes. Additionally, increased fullness in individuals with PD does not appear to be accounted for by exaggerated postprandial GLP-1 release.
authors.affiliation: Department of Biomedical Sciences, Florida State University, Tallahassee, Florida; Program in Neuroscience, Florida State University, Tallahassee, Florida.
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Dossat
authors.forename: Lindsay P
authors.initials: LP
authors.lastname: Bodell
authors.forename: Diana L
authors.initials: DL
authors.lastname: Williams
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Eckel
authors.forename: Pamela K
authors.initials: PK
authors.lastname: Keel
mesh_terms: D000328:Adult; D056912:Binge-Eating Disorder / Q000097:blood / Q000523:psychology; D052018:Bulimia Nervosa / Q000097:blood / Q000523:psychology; D016022:Case-Control Studies; D005247:Feeding Behavior / Q000523:psychology; D001068:Feeding and Eating Disorders / Q000097:blood* / Q000523:psychology; D005260:Female; D052216:Glucagon-Like Peptide 1 / Q000378:metabolism*; D006801:Humans; D006815:Hunger / Q000502:physiology; D019518:Postprandial Period / Q000502:physiology; D012527:Satiation / Q000502:physiology
chemical_list: D052216:Glucagon-Like Peptide 1
keywords: bulimia nervosa; glucagon-like peptide-1; objective binge-eating episode; purging disorder; subjective binge-eating episode