title: Evaluation of mean platelet volume, neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in advanced stage endometriosis with endometrioma.
abstract: OBJECTIVE
  We compared the preoperative values of mean platelet volume (MPV) and peripheral systemic inflammatory response (SIR) markers (neutrophil/lymphocyte ratio and platelet/lymphocyte ratio) between patients with advanced-stage (stage 3/4) endometriosis having endometrioma (OMA) and patients with a non-neoplastic adnexal mass other than endometrioma (non-OMA).
  
  
  METHODS
  Patients who underwent operations with the pre-diagnosis of infertility or adnexal mass and who underwent laparoscopic tubal ligation were included.
  
  
  RESULTS
  Haemoglobin levels, leucocyte count, platelet count, neutrophil count and lymphocyte count were not significantly different between patients with advanced stage endometriosis having OMA, patients with non-OMA and patients in the control group (p=0.970, p=0.902, p=0.373, p=0.501 and p=0.463, respectively). Patients with stage 3/4 endometriosis having OMA, patients with non-OMA and control patients were also not significantly different in terms of MPV (p=0.836), neutrophil/lymphocyte ratio (NLR) (p=0.555) and platelet/lymphocyte ratio (PLR) (p=0.358). Preoperative cancer antigen 125 (Ca-125) levels were significantly higher in patients with OMA (p=0.006). Mean size of the OMAs was significantly lower than non-OMAs (p=0.000).
  
  
  CONCLUSIONS
  It is very important to determine advanced stage endometriosis and OMAs during preoperative evaluation in order to inform patients and plan an appropriate surgical approach. We demonstrate that MPV, NLR and PLR values are not useful for this purpose in patients with advanced stage endometriosis that are proven to develop severe inflammation at either the cellular or molecular level.
authors.affiliation: Department of Obstetrics and Gynecology, Düzce University Faculty of Medicine, Düzce, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yavuzcan
authors.affiliation: Department of Obstetrics and Gynecology, Düzce University Faculty of Medicine, Düzce, Turkey.
authors.forename: Mete
authors.initials: M
authors.lastname: Cağlar
authors.affiliation: Department of Obstetrics and Gynecology, Düzce University Faculty of Medicine, Düzce, Turkey.
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Ustün
authors.affiliation: Department of Obstetrics and Gynecology, Düzce University Faculty of Medicine, Düzce, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Dilbaz
authors.affiliation: Department of Obstetrics and Gynecology, İstanbul Medicana Beylikdüzü Hospital, İstanbul, Turkey.
authors.forename: Ismail
authors.initials: I
authors.lastname: Ozdemir
authors.affiliation: Department of Obstetrics and Gynecology, Düzce University Faculty of Medicine, Düzce, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Yıldız
authors.affiliation: Department of Obstetrics and Gynecology, Düzce University Faculty of Medicine, Düzce, Turkey.
authors.forename: Atilla
authors.initials: A
authors.lastname: Ozkara
authors.affiliation: Department of Obstetrics and Gynecology, Düzce University Faculty of Medicine, Düzce, Turkey.
authors.forename: Selahattin
authors.initials: S
authors.lastname: Kumru
keywords: Endometriosis; mean platelet volume; neutrophil/lymphocyte ratio; platelet/lymphocyte ratio