title: Cost-effectiveness of asenapine in the treatment of schizophrenia in Canada.
abstract: OBJECTIVE
  Asenapine is the first tetracyclic antipsychotic approved in Canada for the treatment of schizophrenia (SCZ). Asenapine has shown a comparable efficacy profile to other atypical antipsychotics and it is associated with a favourable metabolic profile and less weight gain. This study aimed to assess the economic impact of asenapine compared to other atypical antipsychotics in the treatment of SCZ in Canada.
  
  
  METHODS
  A decision tree combined with a Markov model was constructed to assess the cost-utility of asenapine compared with other atypical antipsychotics. The decision tree takes into account the occurrence of extrapyramidal symptoms, the probability of switching to a different antipsychotic, and the probability of gaining weight. The Markov model takes into account long-term metabolic complications including diabetes, hypertension, coronary heart diseases, and stroke. In the base-case analysis, asenapine was compared to olanzapine. Asenapine was also compared with other atypical antipsychotics commonly used in Canada in alternative scenarios. Analyses were conducted from both Canadian Ministry of Health (MoH) and societal perspectives over a 5-year time horizon.
  
  
  RESULTS
  In the treatment of SCZ, asenapine is a dominant strategy over olanzapine from both MoH and societal perspectives. Compared to quetiapine, asenapine is also a dominant strategy. Furthermore, asenapine has a favorable economic impact compared to ziprasidone and aripiprazole, as these antipsychotics are not cost-effective compared to asenapine from both MoH and societal perspectives.
  
  
  CONCLUSIONS
  Despite the short time horizon, the lack of compliance data and the assumptions made, this economic evaluation demonstrates that asenapine is a cost-effective strategy compared to olanzapine and to most of the atypical antipsychotics frequently used in Canada.
authors.affiliation: Faculty of Pharmacy, University of Montreal , Montreal, Quebec , Canada.
authors.forename: Jean
authors.initials: J
authors.lastname: Lachaine
authors.forename: Catherine
authors.initials: C
authors.lastname: Beauchemin
authors.forename: Karine
authors.initials: K
authors.lastname: Mathurin
authors.forename: Dominique
authors.initials: D
authors.lastname: Gilbert
authors.forename: Maud
authors.initials: M
authors.lastname: Beillat
mesh_terms: D014150:Antipsychotic Agents / Q000191:economics* / Q000627:therapeutic use*; D002170:Canada; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D003986:Dibenzocycloheptenes; D006296:Health Services / Q000191:economics / Q000706:statistics & numerical data; D006576:Heterocyclic Compounds, 4 or More Rings / Q000191:economics* / Q000627:therapeutic use*; D006801:Humans; D008390:Markov Chains; D018803:Models, Economic; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D003986:Dibenzocycloheptenes; D006576:Heterocyclic Compounds, 4 or More Rings; C522667:asenapine