title: [Formulation of multiparticular drug delivery systems by compressing pellets into tablets].
abstract: The use of multiparticulate drug delivery systems can contribute to more efficient and safe therapy while stability and incompatibility problems can be avoided as well. The aim of the present work was to review the possible ways of production of pellets containing multiparticulate units and studying the most important factors influencing the product quality attributes after tablet compression. The relationship between the formulation variables (compression pressures, different amounts of tableting excipients) and the dissolution profile of the gastroresistant coated beads were investigated.
authors.affiliation: Semmelweis Egyetem, Gyógyszerészi Intézet, 1092 Budapest, Hogyes Endre utca 7-9.
authors.forename: Zsombor
authors.initials: Z
authors.lastname: Csobán
authors.affiliation: Semmelweis Egyetem, Gyógyszerészi Intézet, 1092 Budapest, Hogyes Endre utca 7-9.
authors.forename: Nikolett
authors.initials: N
authors.lastname: Kállai
authors.affiliation: Semmelweis Egyetem, Gyógyszerészi Intézet, 1092 Budapest, Hogyes Endre utca 7-9.
authors.forename: Adám
authors.initials: A
authors.lastname: Polgár
authors.affiliation: Semmelweis Egyetem, Gyógyszerészi Intézet, 1092 Budapest, Hogyes Endre utca 7-9.
authors.forename: István
authors.initials: I
authors.lastname: Antal
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems; D004343:Drug Implants; D005079:Excipients / Q000737:chemistry; D013607:Tablets / Q000138:chemical synthesis*
chemical_list: D004343:Drug Implants; D005079:Excipients; D013607:Tablets