title: Dabigatran-induced lupus temporarily preventing blood group determination.
abstract: Epistaxis resulted in severe anemia in an 89-year-old Caucasian woman under a therapy with dabigatran for 12 months because of atrial fibrillation. Correction of the anemia was difficult because it was impossible to assess her blood group due to polyagglutination. Since hospital records disclosed that in 2011, her blood group was O positive, acquired polyagglutination was assumed. After 66 days, it was again possible to assess the blood group as O positive. Immunologic investigations disclosed that antinuclear antibodies and antihistone antibodies were elevated, and antibodies to double-stranded DNA were negative. Drug-induced lupus was diagnosed due to the autoantibody profile detected.
authors.affiliation: aKrankenanstalt Rudolfstiftung bImmunology Outpatient Clinic, Wien, Austria.
authors.forename: Claudia
authors.initials: C
authors.lastname: Stöllberger
authors.forename: Gabriele
authors.initials: G
authors.lastname: Krutisch
authors.forename: Josef
authors.initials: J
authors.lastname: Finsterer
authors.forename: Hermann Maximilian
authors.initials: HM
authors.lastname: Wolf
mesh_terms: D000369:Aged, 80 and over; D000740:Anemia / Q000097:blood / Q000139:chemically induced*; D000974:Antibodies, Antinuclear / Q000097:blood; D000991:Antithrombins / Q000008:administration & dosage / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000503:physiopathology; D001562:Benzimidazoles / Q000008:administration & dosage / Q000009:adverse effects*; D001777:Blood Coagulation; D001789:Blood Group Antigens / Q000032:analysis; D000069604:Dabigatran; D004844:Epistaxis / Q000097:blood / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000139:chemically induced*; D015091:beta-Alanine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000974:Antibodies, Antinuclear; D000991:Antithrombins; D001562:Benzimidazoles; D001789:Blood Group Antigens; D007136:Immunoglobulins; D015091:beta-Alanine; D000069604:Dabigatran