title: Hydrothermal preparation and characterization of ultralong strontium-substituted hydroxyapatite whiskers using acetamide as homogeneous precipitation reagent.
abstract: The ultralong strontium- (Sr-) substituted hydroxyapatite (SrHAp) whiskers were successfully prepared using acetamide as homogeneous precipitation reagent. The effect of the Sr substitution amount on the lattice constants and proliferation of human osteoblast cells (MG-63) was further investigated. The results showed that the SrHAp whiskers with diameter of 0.2-12 μm and ultralong length up to 200 μm were obtained and the Sr substitution level could be facilely tailored by regulating the initial molar ratio of Sr/(Sr + Ca) in raw materials. The Sr(2+) replaced part of Ca(2+) and the lattice constants increased apparently with the increase of the Sr substitution amount. Compared with the pure HAp whiskers, the Sr substitution apparently stimulated the proliferation of MG-63 at certain extracted concentrations. Our study suggested that the obtained SrHAp whiskers might be used as bioactive and mechanical reinforcement materials for hard tissue regeneration applications.
authors.affiliation: Department of Orthopaedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Orthopaedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China.
authors.forename: Yaoqi
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Department of Orthopaedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China.
authors.forename: Rong
authors.initials: R
authors.lastname: Wan
authors.affiliation: Department of Orthopaedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China.
authors.forename: Yuhui
authors.identifier: 0000-0002-9220-6473
authors.initials: Y
authors.lastname: Shen
authors.affiliation: Department of Orthopaedics, Shanghai Institute of Orthopaedics and Traumatology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China.
authors.forename: Weibin
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000081:Acetamides / Q000737:chemistry; D045744:Cell Line, Tumor; D017886:Durapatite / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D010006:Osteoblasts / Q000187:drug effects*
chemical_list: D000081:Acetamides; C509320:strontium-containing hydroxyapatite; C030686:acetamide; D017886:Durapatite