title: Actigraphic motor activity in mild cognitive impairment patients carrying out short functional activity tasks: comparison between mild cognitive impairment with and without depressive symptoms.
abstract: BACKGROUND
  Individuals with mild cognitive impairment (MCI) may exhibit changes in motor activity in conducting their activities of daily living. Depression, one of the most frequent neuropsychiatric symptoms, might affect motor activity in MCI.
  
  
  OBJECTIVE
  To assess motor activity in MCI subjects carrying out short functional activity tasks using ambulatory actigraphy. Secondly, we sought to investigate the influence of depressive symptoms on motor activity.
  
  
  METHODS
  20 MCI and 14 healthy subjects carried out a 30-minute standardized scenario while wearing a chest actigraph. The protocol consisted of directed activities (execution of motor tasks), semi-directed activities (execution of Instrumental Activities of Daily Living, IADL), and undirected 'free' activities. Several common assessment scales (GDS, MADRS, and NPI) were used to diagnose depression.
  
  
  RESULTS
  MCI subjects had significantly reduced mean motor activity while carrying out directed and semi-directed activities, compared to healthy control subjects. No difference was found in motor activity between MCI subjects with or without depression.
  
  
  CONCLUSIONS
  Actigraphic measurement of motor activity during the evaluation of IADLs and motor tasks is a potential objective tool in detecting early changes in MCI. Depressive symptoms seem not to be associated with motor activity in MCI subjects.
authors.affiliation: EA CoBTeK, CHU University of Nice Sophia Antipolis, Nice, France Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Maja
authors.initials: M
authors.lastname: Yakhia
authors.affiliation: EA CoBTeK, CHU University of Nice Sophia Antipolis, Nice, France School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht, The Netherlands.
authors.forename: Alexandra
authors.initials: A
authors.lastname: König
authors.affiliation: Alzheimer Center & Department of Neurology, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Wiesje M
authors.initials: WM
authors.lastname: van der Flier
authors.affiliation: VA Palo Alto Health Care System, Palo Alto, CA, USA.
authors.forename: Leah
authors.initials: L
authors.lastname: Friedman
authors.affiliation: EA CoBTeK, CHU University of Nice Sophia Antipolis, Nice, France Centre Mémoire de Ressources de Recherche - CHU University of Nice Sophia Antipolis, Nice, France.
authors.forename: Philippe H
authors.initials: PH
authors.lastname: Robert
authors.affiliation: EA CoBTeK, CHU University of Nice Sophia Antipolis, Nice, France Centre Mémoire de Ressources de Recherche - CHU University of Nice Sophia Antipolis, Nice, France.
authors.forename: Renaud
authors.initials: R
authors.lastname: David
mesh_terms: D056044:Actigraphy; D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D060825:Cognitive Dysfunction / Q000150:complications*; D003863:Depression / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009483:Neuropsychological Tests; D018709:Statistics, Nonparametric
keywords: Actigraphy; depressive symptoms; mild cognitive impairment; motor activity