title: Garcinielliptone FC, a polyisoprenylated benzophenone from Platonia insignis Mart., promotes vasorelaxant effect on rat mesenteric artery.
abstract: Polyisoprenylated benzophenones represent a group of chemical compounds commonly identified in Clusiaceae species and are responsible for a large amount of biological activities. In this work, the vasorelaxant effect induced by garcinielliptone FC (GFC) isolated from Platonia insignis Mart. (Clusiaceae), a monotype species from Platonia genus, was investigated. GFC promoted an endothelium-independent vasorelaxation on phenylephrine (PHE, 10(-5) mol L(-1))-induced vasoconstriction, but not on KCl (80 mmol L(-1))-induced vasoconstriction, on rat superior mesenteric artery rings. In addition, a concentration-dependent decrease of PHE- or serotonin-induced cumulative concentration-response curves was observed for GFC, and a slight decrease of pD₂ value on CaCl₂-induced vasoconstriction. In a Ca(2+)-free medium, GFC interfered in calcium mobilisation from PHE (10(-5) mol L(-1))-sensitive intracellular stores. GFC-induced vasorelaxant effect is probably mediated by a dual effect on mobilisation of calcium intracellular stores and attenuation of transmembrane calcium influx.
authors.affiliation: a Medicinal Plants Research Center, Federal University of Piauí , Campus Ministro Petrônio Portella, SG-15, Ininga, CEP 64049-550 Teresina , PI , Brazil.
authors.forename: Daniel Dias Rufino
authors.initials: DD
authors.lastname: Arcanjo
authors.forename: Joaquim Soares
authors.initials: JS
authors.lastname: da Costa-Júnior
authors.forename: Lucas Henrique Porfírio
authors.initials: LH
authors.lastname: Moura
authors.forename: Alexandre Barros Falcão
authors.initials: AB
authors.lastname: Ferraz
authors.forename: Raíssa Rebés
authors.initials: RR
authors.lastname: Rossatto
authors.forename: Jorge Maurício
authors.initials: JM
authors.lastname: David
authors.forename: Lucindo José
authors.initials: LJ
authors.lastname: Quintans-Júnior
authors.forename: Rita de Cássia Meneses
authors.initials: Rde C
authors.lastname: Oliveira
authors.forename: Antônia Maria das Graças Lopes
authors.initials: AM
authors.lastname: Citó
authors.forename: Aldeídia Pereira
authors.initials: AP
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002118:Calcium / Q000032:analysis / Q000378:metabolism; D028084:Clusiaceae / Q000737:chemistry*; D008638:Mesenteric Arteries / Q000187:drug effects*; D015394:Molecular Structure; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014664:Vasodilation / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D001577:Benzophenones; D014315:Triterpenes; D014665:Vasodilator Agents; C573355:garcinielliptone FC; D010656:Phenylephrine; D002118:Calcium
keywords: Clusiaceae; Platonia; benzophenone; calcium; garcinielliptone; vasorelaxant