title: Impact of metabolic syndrome on fractional flow reserve.
abstract: OBJECTIVE
  Fractional flow reserve (FFR) assessment is widely used to determine significance of intermediate coronary lesions. Previously, components of the metabolic syndrome (MS) which may affect FFR validity were not tested cumulatively. In this study, we investigate the possible effect of MS on FFR assessment.
  
  
  RESULTS
  We retrospectively evaluated 178 consecutive patients who had undergone FFR assessment. Thirty-two patients were excluded. All of the coronary lesions were in the left anterior descending artery. They were evaluated with quantitative coronary angiography (QCA). In 105 patients the MS was present and 41 patients were without the MS. According to the severity of the coronary lesions in QCA, patients were divided into three groups: 40-50%, 51-60% and 61-70% lesions. FFR measurements were compared in each group with respect to MS presence. Coronary artery lesions were accepted as haemodynamically significant if FFR < or = 0.80. Age of the population, lesion length, lesion diameter and adenosine dosage performed during FFR assessment were not different between patients with MS or without MS. When the lesions were divided into three categories according to the severity of the luminal narrowing expressed in stenosis percentages as 40-50, 51-60, and more than 61%, the observed FFR values decreased with advancing lesion category (P = 0.04). However, observed FFR values did not differ between the patients with MS and without MS in each category (P = 0.88). After exclusion of the diabetic patients, FFR values still did not differ between the patients with MS and without MS in each category (P = 0.78).
  
  
  CONCLUSIONS
  Presence of the metabolic syndrome has no significant effect on FFR assessment. This study provides additional data for the reliability of FFR in patients with MS.
authors.affiliation: Dept. of Cardiology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
authors.forename: Pinar Türker
authors.initials: PT
authors.lastname: Bayir
authors.affiliation: Dept. of Cardiology, Hakkari State Hospital, Hakkari, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Duyuler
authors.affiliation: Dept. of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Güray
authors.affiliation: Dept. of Cardiology, Cubuk Halil Sivgin State Hospital, Ankara, Turkey.
authors.forename: Belma
authors.initials: B
authors.lastname: Kalayci
authors.affiliation: Dept. of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey.
authors.forename: Süleyman
authors.initials: S
authors.lastname: Kalayci
authors.affiliation: Dept. of Cardiology, Kartal Koşuyolu Yuksek Ihtisas Hospital, Istanbul, Turkey.
authors.forename: Sinan
authors.initials: S
authors.lastname: Cerşit
authors.affiliation: Dept. of Cardiology, Muş State Hospital, Muş, Turkey.
authors.forename: Murat
authors.initials: M
authors.lastname: Gençaslan
mesh_terms: D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D003331:Coronary Vessels / Q000503:physiopathology*; D005260:Female; D053805:Fractional Flow Reserve, Myocardial / Q000502:physiology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies