title: 68Ga chelating bioorthogonal tetrazine polymers for the multistep labeling of cancer biomarkers.
abstract: We have developed a (68)Ga metal chelating bioorthogonal tetrazine dextran probe that is highly reactive with trans-cyclooctene modified monoclonal antibodies for multistep imaging applications. Confocal microscopy and positron emission tomography (PET) were used to characterize the dextran probe in vitro and in vivo.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Brandon
authors.initials: B
authors.lastname: Nichols
authors.affiliation: Department of Radiology, UCSD in vivo Cancer and Molecular Imaging Center, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Zhengtao
authors.initials: Z
authors.lastname: Qin
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Department of Radiology, UCSD in vivo Cancer and Molecular Imaging Center, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Vera
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093, USA.
authors.forename: Neal K
authors.initials: NK
authors.lastname: Devaraj
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D014408:Biomarkers, Tumor / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003911:Dextrans / Q000737:chemistry; D005710:Gallium Radioisotopes / Q000737:chemistry*; D006801:Humans; D008562:Membrane Glycoproteins / Q000276:immunology; D051379:Mice; D004369:Pentetic Acid / Q000737:chemistry; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000737:chemistry; D013777:Tetrazoles / Q000737:chemistry*; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured
chemical_list: D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D002614:Chelating Agents; D003911:Dextrans; D005710:Gallium Radioisotopes; C504395:Gpa33 protein, mouse; D008562:Membrane Glycoproteins; D011108:Polymers; D019275:Radiopharmaceuticals; D013777:Tetrazoles; D004369:Pentetic Acid