title: Maternal obesity and excess of fetal growth in pre-eclampsia.
abstract: OBJECTIVE
  To assess whether the reported excess of large for gestational age (LGA) neonates in pre-eclamptic women delivering at term is attributable to maternal obesity.
  
  
  METHODS
  Population-based observational study including 77,294 singleton pregnancies registered in the Medical Birth Registry of Norway between 2007 and 2010.
  
  
  METHODS
  Comparison of birthweight percentiles and z-scores between women with and without pre-eclampsia.
  
  
  METHODS
  Odds ratio (OR) of LGA and z-scores of birthweight in relation to pre-eclampsia.
  
  
  RESULTS
  Pre-eclamptic women delivering at term had increased risk of having LGA neonates. Unadjusted ORs with 95% confidence interval (95% CI) of LGA above the 90th and 95th birthweight centiles were 1.4, 95% CI 1.2-1.6 and 1.6, 95% CI 1.3-1.9, respectively. The excess of LGA persisted after including gestational diabetes and diabetes types 1 and 2 in a multivariate analysis (corresponding ORs 1.3, 95% CI 1.1-1.5 and 1.4, 95% CI 1.2-1.7), but disappeared after adjusting for maternal prepregnant body mass index (ORs 1.1, 95% CI 0.9-1.2 and 1.1, 95% CI 0.9-1.3).
  
  
  CONCLUSIONS
  This study suggests accelerated fetal growth in a subset of pre-eclamptic women delivering at term. The excess of LGA neonates is attributable to maternal obesity among pre-eclamptic women delivering at term. The maternal obesity epidemic may lead to an increased prevalence of both pre-eclampsia and LGA neonates among women delivering at term.
authors.affiliation: Department of Clinical Science, University of Bergen, Bergen, Norway; Department of Obstetrics and Gynaecology, Haukeland University Hospital, Bergen, Norway.
authors.forename: S
authors.initials: S
authors.lastname: Rasmussen
authors.forename: L M
authors.initials: LM
authors.lastname: Irgens
authors.forename: J
authors.initials: J
authors.lastname: Espinoza
mesh_terms: D000293:Adolescent; D000328:Adult; D001724:Birth Weight; D005260:Female; D005320:Fetal Macrosomia / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D009664:Norway; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D012307:Risk Factors
keywords: Birthweight; body mass index; large for gestational age; pre-eclampsia