title: Cutaneous metastases during an aggressive course of Xp11.2 translocation renal cell carcinoma in a teenager.
abstract: We reported a rare case of cutaneous metastases of renal cell carcinoma (RCC) with an Xp11.2 translocation in a 15-year-old female. Clinicians should be aware of the possibility of this uncommon site of metastasis, which can indicate multivisceral dissemination of the disease. We discuss the feasibility and opportunity of treating such a patient with multiple line of tyrosine kinase inhibitor (TKI) targeting vascular endothelial and platelet-derived growth factor receptors.
authors.affiliation: Pediatric Oncology Unit, Anti Cancer Center Oscar Lambret, Lille Cedex, France.
authors.forename: Helene
authors.initials: H
authors.lastname: Sudour-Bonnange
authors.forename: Xavier
authors.initials: X
authors.lastname: Leroy
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Chauvet
authors.forename: Marion
authors.initials: M
authors.lastname: Classe
authors.forename: P M
authors.initials: PM
authors.lastname: Robin
authors.forename: Pierre
authors.initials: P
authors.lastname: Leblond
mesh_terms: D000293:Adolescent; D002292:Carcinoma, Renal Cell / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D011379:Prognosis; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000556:secondary*; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D047428:Protein Kinase Inhibitors
keywords: Xp11.2 RCC; cutaneous metastasis; teenager; tyrosine kinase inhibitors