title: Treatment of suspected hyper-reactive malarial splenomegaly (HMS) in pregnancy with mefloquine.
abstract: Malaria infections in pregnancy are associated with adverse outcomes for both mother and child. There are few data on hyper-reactive malarial splenomegaly, an aberrant immunological response to chronic or recurrent malaria in pregnancy. This retrospective assessment reviewed the impact of mefloquine treatment on pregnant women with suspected hyper-reactive malarial splenomegaly in an area of low malaria transmission in the 1990s, showing significant reductions in spleen size and anemia and anti-malarial antibody titers without any notable negative effect on treated women or their newborns.
authors.forename: Juthamas
authors.initials: J
authors.lastname: Jaroensuk
authors.forename: Nicole
authors.initials: N
authors.lastname: Stoesser
authors.forename: Mara L
authors.initials: ML
authors.lastname: Leimanis
authors.forename: Podjanee
authors.initials: P
authors.lastname: Jittamala
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: White
authors.forename: Francois H
authors.initials: FH
authors.lastname: Nosten
authors.forename: Rose
authors.initials: R
authors.lastname: McGready
mesh_terms: D000328:Adult; D000913:Antibodies, Protozoan / Q000276:immunology; D000962:Antimalarials / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006971:Hypersplenism / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008288:Malaria / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D015767:Mefloquine / Q000627:therapeutic use*; D010961:Plasmodium / Q000276:immunology; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000188:drug therapy* / Q000276:immunology; D012189:Retrospective Studies; D013163:Splenomegaly / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan; D000962:Antimalarials; D007075:Immunoglobulin M; D015767:Mefloquine