title: [Role of the prefrontal cortex in human behavioral adaptation].
abstract: Behavioral adaptation to complex or new situations depends on the anatomical, physiological and functional properties of the prefrontal cortex, and on its interaction with other regions. These properties allow distinguishing two main prefrontal regions: the lateral part involved in cognitive aspects of goal-directed behaviors, and the ventral part involved in its affective aspects. Damage to these two regions is associated with two distinct clinical syndromes. Cognitive deficits in planning dominate in the lateral syndrome, behavioral regulation and motivation disorders in the ventral syndrome. Beyond this distinction, the question of how the systems that enable cognitive and behavioral aspects of adaptation are organized in prefrontal subregions, and can be best assessed, is not fully understood. This question is an essential issue in cognitive neuroscience and is crucial to improve clinical practice.
authors.affiliation: Université Pierre et Marie Curie-Paris 6, Centre de recherche de l'institut du cerveau et de la moelle épinière (Cricm), UMRS 975, hôpital Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France - Inserm U1127, Paris, France - CNRS, UMR 7225, Paris, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Volle
authors.affiliation: Université Pierre et Marie Curie-Paris 6, Centre de recherche de l'institut du cerveau et de la moelle épinière (Cricm), UMRS 975, hôpital Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France - Inserm U1127, Paris, France - CNRS, UMR 7225, Paris, France - AP-HP, hôpital Saint-Antoine, service de neurologie, 184, rue du faubourg Saint-Antoine, 75012 Paris, France.
authors.forename: Richard
authors.initials: R
authors.lastname: Levy
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology*; D001519:Behavior / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D006801:Humans; D009042:Motivation / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology*