title: Neurolymphomatosis in a patient with extranodal NK/T-cell lymphoma, nasal-type: a case report and literature review.
abstract: A 47-year-old man presented with a fever and lower extremity paresthesia. A physical examination revealed sensory deficits in the left hand, distal arm and right sole. A bone marrow aspiration demonstrated infiltration of extranodal NK/T-cell lymphoma, nasal type, and (18)F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) disclosed extensive involvement of the peripheral nerves. These findings were consistent with a diagnosis of neurolymphomatosis (NL). The lymphoma progressed soon after the patient underwent cord blood transplantation, and he died on day 33 after transplantation. NL is a rare manifestation of lymphoma characterized by infiltration of the peripheral nerves, leading to neuropathy. It is an increasingly recognized entity and can be the first indication of lymphoma.
authors.affiliation: Department of Hematology, Nagano Red Cross Hospital, Japan.
authors.forename: Ikuo
authors.initials: I
authors.lastname: Shimizu
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hamano
authors.forename: Shunichi
authors.initials: S
authors.lastname: Sato
authors.forename: Wataru
authors.initials: W
authors.lastname: Takeda
authors.forename: Takehiko
authors.initials: T
authors.lastname: Kirihara
authors.forename: Keijiro
authors.initials: K
authors.lastname: Sato
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Ueki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Hiroshima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Sumi
authors.forename: Mayumi
authors.initials: M
authors.lastname: Ueno
authors.forename: Naoaki
authors.initials: N
authors.lastname: Ichikawa
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009423:Nervous System Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D009669:Nose Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D049268:Positron-Emission Tomography / Q000379:methods