title: Meta-analysis of phospholipase C epsilon 1 polymorphism and cancer risk.
abstract: BACKGROUND
  Phospholipase C epsilon 1 (PLCE1) plays crucial roles in carcinogenesis and progression of several cancers. A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus.
  
  
  METHODS
  To evaluate the role of the Phospholipase C epsilon 1 (PLCE1) polymorphism in cancer susceptibility. We performed a meta-analysis of all available studies, including 8,689 cases and 10,794 controls to derive a more precise relationship. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between PLCE1 rs2274223 polymorphism and cancer risk.
  
  
  RESULTS
  A total of 14 case-control studies were included in the present meta-analysis. Overall significant associations were observed (AG vs. AA: OR=1.17, 95%CI=1.04-1.31; GG vs. AA: OR=1.32, 95%CI=1.06-1.66; AG/GG vs. AA: OR=1.19, 95%CI=1.05-1.34; G vs. A: OR=1.16, 95%CI=1.04-1.29) in all cancer types. In the subgroup analysis, PLCE1 rs2274223 polymorphism was significantly increased risk of cancer in Chinese population by ethnicity and upper aerodigestive tract cancer by cancer types.
  
  
  CONCLUSIONS
  Our meta-analysis suggested the PLCE1 rs2274223 might act as a cancer risk factor among all subjects, especially in the Chinese population and upper aerodigestive tract cancer.
authors.affiliation: Institute of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Institute of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Ruixia
authors.initials: R
authors.lastname: Wang
authors.affiliation: Institute of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Longbiao
authors.initials: L
authors.lastname: Zhu
authors.affiliation: Education and Scientific Research Department, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, China.
authors.forename: Shangyue
authors.initials: S
authors.lastname: Zhang
authors.affiliation: Institute of Stomatology, Nanjing Medical University, Nanjing, China Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Centre, Nanjing Medical University, Nanjing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Institute of Stomatology, Nanjing Medical University, Nanjing, China.
authors.forename: Hongbing
authors.initials: H
authors.lastname: Jiang
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D054801:Phosphoinositide Phospholipase C / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide
chemical_list: D054801:Phosphoinositide Phospholipase C; C423320:phospholipase C epsilon
keywords: Meta-analysis; PLCE1; cancer; polymorphism; rs2274223