title: The wonders of 2-deoxy-D-glucose.
abstract: Through the eons of time, out of all possible configurations, nature has selected glucose not only as a vital source of energy to sustain life but also as the molecule who's structure supplies the appropriate elements required for a cell to grow and multiply. This understanding, at least in part, explains the profound effects that the analog of glucose, 2-deoxy-d-glucose, has been shown to have on as common and widespread diseases as cancer, viral infection, aging-related morbidity, epilepsy, and others. This review is confined to summarizing some of the salient findings of this remarkable compound as they relate mainly to cancer.
authors.affiliation: Department of Microbiology, Immunology and Molecular Genetics, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, USA.
authors.forename: Haibin
authors.initials: H
authors.lastname: Xi
authors.forename: Metin
authors.initials: M
authors.lastname: Kurtoglu
authors.forename: Theodore J
authors.initials: TJ
authors.lastname: Lampidis
mesh_terms: D017209:Apoptosis / Q000235:genetics; D001343:Autophagy / Q000235:genetics; D003847:Deoxyglucose / Q000235:genetics / Q000378:metabolism*; D059865:Endoplasmic Reticulum Stress / Q000235:genetics*; D006031:Glycosylation; D006801:Humans; D000860:Hypoxia; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D014779:Virus Replication / Q000235:genetics*
chemical_list: D003847:Deoxyglucose
keywords: 2-deoxy-d-glucose; apoptosis; autophagy; endoplasmic reticulum stress; glycosylation; hypoxia; viral replication