title: HeartWare left ventricular assist device thrombosis in aspirin non-responder.
abstract: Patient characteristics that increase the risk of continuous-flow left ventricular assist device thrombosis have not been well established. We report a case of HeartWare thrombosis in a patient with aspirin hyporesponsiveness, and discuss the role of platelet function testing in preventing this severe complication. There is a need for clinical trials determining optimal antiplatelet therapy in patients supported with left ventricular assist devices, and consensus regarding modification of antiplatelet therapy after device thrombosis.
authors.affiliation: Department of Molecular Medicine and Surgery, Department of Cardiothoracic Surgery and Anesthesiology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Dalén
authors.forename: Ulrik
authors.initials: U
authors.lastname: Sartipy
authors.forename: Matthias
authors.initials: M
authors.lastname: Corbascio
authors.forename: Lars H
authors.initials: LH
authors.lastname: Lund
authors.forename: Karl-Henrik
authors.initials: KH
authors.lastname: Grinnemo
mesh_terms: D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D000077144:Clopidogrel; D004351:Drug Resistance; D057915:Drug Substitution; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011474:Prosthesis Design; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin
keywords: Aspirin; drug resistance; heart-assist devices; platelet aggregation; thromboembolism