title: Using viruses as nanomedicines.
abstract: The field of nanomedicine involves the design and fabrication of novel nanocarriers for the intracellular delivery of therapeutic cargo or for use in molecular diagnostics. Although traditionally recognized for their ability to invade and infect host cells, viruses and bacteriophages have been engineered over the past decade as highly promising molecular platforms for the targeted delivery and treatment of many human diseases. Inherently biodegradable, the outer capsids of viruses are composed entirely of protein building blocks, which can be genetically or chemically engineered with molecular imaging reagents, targeting ligands and therapeutic molecules. While there are several examples of viruses as in vitro molecular cargo carriers, their potential for applications in nanomedicine has only recently emerged. Here we highlight recent developments towards the design and engineering of viruses for the treatment of cancer, bacterial infections and immune system-related diseases.
authors.affiliation: Department of Biomolecular Nanotechnology, MESA+ Institute for Nanotechnology, University of Twente, Enschede, The Netherlands.
authors.forename: H E
authors.initials: HE
authors.lastname: van Kan-Davelaar
authors.forename: J C M
authors.initials: JC
authors.lastname: van Hest
authors.forename: J J L M
authors.initials: JJ
authors.lastname: Cornelissen
authors.forename: M S T
authors.initials: MS
authors.lastname: Koay
mesh_terms: D002213:Capsid / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods; D005818:Genetic Engineering; D006801:Humans; D008024:Ligands; D057054:Molecular Imaging / Q000379:methods*; D050997:Nanomedicine / Q000379:methods*; D014780:Viruses / Q000235:genetics* / Q000276:immunology / Q000378:metabolism
chemical_list: D008024:Ligands