title: Measurement of antioxidant capacity using the biological antioxidant potential test and its role as a predictive marker of metabolic syndrome.
abstract: OBJECTIVE
  Oxidative stress increases the risk of cardiovascular complications of metabolic syndrome (MetS). This study was conducted to examine the difference in antioxidant capacity according to the presence of MetS, and to characterize the association between antioxidant capacity and MetS-related factors.
  
  
  METHODS
  We used the biological antioxidant potential (BAP) test to estimate antioxidant capacity. The BAP test has recently been used as an indicator of antioxidant capacity. We measured BAP levels in 45 patients with MetS (mean age, 44.6 ± 1.1 years) and 47 age- and sex-matched controls (mean age, 42.7 ± 1.1 years). To evaluate the association between antioxidant capacity and MetS, adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin-6, tumor necrosis factor-α, and homeostatic model assessment for insulin resistance (HOMA-IR), linear regression and logistic analyses were performed.
  
  
  RESULTS
  The mean BAP of the MetS group (1,937.3 ± 36.5 µmol/L) was significantly lower than that of the non-MetS group (2,101.7 ± 29.5 µmol/L). Also, the mean BAP was low in persons having low high density lipoprotein and high triglyceride. Reduced antioxidant capacity was significantly associated with adiponectin, HOMA-IR and hs-CRP after adjusting for age and sex. The odds ratios for MetS with BAP, log adiponectin, log HOMA-IR, and log hs-CRP were 0.63 (95% confidence interval [CI], 0.49 to 0.82), 0.22 (0.10 to 0.51), 14.24 (4.35 to 46.58), and 1.93 (1.36 to 2.75), respectively.
  
  
  CONCLUSIONS
  Persons with MetS showed reduced antioxidant capacity. We identified relationships between antioxidant capacity measured by BAP test and MetS, as well as MetS-related factors, such as insulin resistance, hs-CRP, and adiponectin.
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Jung Hee
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Hyun Wook
authors.initials: HW
authors.lastname: Baik
authors.affiliation: Department of Family Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea.
authors.forename: Yeong Sook
authors.initials: YS
authors.lastname: Yoon
authors.affiliation: Seoul National University Graduate School of Public Health, Seoul, Korea.
authors.forename: Hyo Jee
authors.initials: HJ
authors.lastname: Joung
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Ju Sang
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Sang Jong
authors.initials: SJ
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Jang
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Sang Woon
authors.initials: SW
authors.lastname: Park
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Sang Jung
authors.initials: SJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Mi Jeoung
authors.initials: MJ
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Dong Ok
authors.initials: DO
authors.lastname: Jeon
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Cho
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Sang Jin
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Sung Gyu
authors.initials: SG
authors.lastname: Im
authors.affiliation: Department of Internal Medicine, Bundang Jesaeng Hospital, Seongnam, Korea.
authors.forename: Sun Kyung
authors.initials: SK
authors.lastname: Jang
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D054392:Adipokines; D000975:Antioxidants; D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein
keywords: Adiponectin; Insulin; Metabolic syndrome; Oxidative stress