title: Symmetric cyanovinyl-pyridinium triphenylamine: a novel fluorescent switch-on probe for an antiparallel G-quadruplex.
abstract: In this study, we present a fluorescent switch-on probe based on a cyanovinyl-pyridinium triphenylamine (CPT) derivative that exhibited a 190-fold increase in fluorescence upon binding to G-quadruplex-forming oligonucleotide 22AG. This probe showed specificity and selectivity towards an antiparallel G-quadruplex, indicating its promising potential in G-quadruplex imaging.
authors.forename: Han
authors.initials: H
authors.lastname: Lai
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, P. R. China. xcweng@whu.edu.cn xzhou@whu.edu.cn.
authors.forename: Hai
authors.initials: H
authors.lastname: Lai
authors.forename: Yijie
authors.initials: Y
authors.lastname: Xiao
authors.forename: Shengyong
authors.initials: S
authors.lastname: Yan
authors.forename: Fangfang
authors.initials: F
authors.lastname: Tian
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhong
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Weng
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
mesh_terms: D005456:Fluorescent Dyes / Q000737:chemistry*; D054856:G-Quadruplexes; D009570:Nitriles / Q000737:chemistry*; D011726:Pyridinium Compounds / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D005456:Fluorescent Dyes; D009570:Nitriles; D011726:Pyridinium Compounds; C000599031:cyanovinyl-pyridinium triphenylamine