title: Activity of caffeic acid derivatives against Candida albicans biofilm.
abstract: The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16μg/mL, respectively, and in the early stage of biofilm formation (4h) with MIC50 values of 64, 32 and 64μg/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24h), especially 8 and 10 with MIC50 values of 64μg/mL.
authors.affiliation: Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: De Vita
authors.affiliation: Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Laura
authors.initials: L
authors.lastname: Friggeri
authors.affiliation: Department of 'Sanità Pubblica e Malattie Infettive', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Felicia Diodata
authors.initials: FD
authors.lastname: D'Auria
authors.affiliation: Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Pandolfi
authors.affiliation: Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Piccoli
authors.affiliation: Department of 'Sanità Pubblica e Malattie Infettive', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Panella
authors.affiliation: Department of 'Sanità Pubblica e Malattie Infettive', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Anna Teresa
authors.initials: AT
authors.lastname: Palamara
authors.affiliation: Department of 'Sanità Pubblica e Malattie Infettive', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy. Electronic address: giovanna.simonetti@uniroma1.it.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Simonetti
authors.affiliation: Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy. Electronic address: luigi.scipione@uniroma1.it.
authors.forename: Luigi
authors.initials: L
authors.lastname: Scipione
authors.affiliation: 'Istituto Pasteur-Fondazione Cenci Bolognetti', Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Di Santo
authors.affiliation: 'Istituto Pasteur-Fondazione Cenci Bolognetti', Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Costi
authors.affiliation: Department of 'Chimica e Tecnologie del Farmaco', Sapienza University of Rome, Piazzale Aldo Moro, 5, 00185 Rome, Italy.
authors.forename: Silvano
authors.initials: S
authors.lastname: Tortorella
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects*; D002109:Caffeic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000502:physiology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D002109:Caffeic Acids; C040048:caffeic acid
keywords: Anti-biofilm agents; Biofilm formation; Caffeic acid; Candida albicans biofilm