title: Favorable outcome with hemoperfusion of polymyxin B-immobilized fiber column for rapidly progressive interstitial pneumonia associated with clinically amyopathic dermatomyositis: report of three cases.
abstract: We present 3 cases of rapidly progressive interstitial pneumonia (RPIP) associated with clinically amyopathic dermatomyositis (C-ADM) that were treated with two courses of direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP). Despite initial treatment with high-dose corticosteroids, pulsed cyclophosphamide, and cyclosporine, the lung disease and hypoxemia deteriorated in all the patients. After PMX-DHP treatment, the PaO2/FiO2 ratio and serum LDH and KL-6 were improved, the abnormal shadows in chest high-resolution computed tomography (HRCT) scans gradually decreased, and, finally, all patients survived. These findings indicate that PMX-DHP treatment could be effective in the management of RPIP in patients with C-ADM in combination with conventional therapy.
authors.affiliation: Department of Respiratory Medicine, Kumamoto University Hospital, Faculty of Life Sciences, Kumamoto University , Kumamoto , Japan.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ichiyasu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Horio
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Tsumura
authors.forename: Susumu
authors.initials: S
authors.lastname: Hirosako
authors.forename: Yasumiko
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Shinya
authors.initials: S
authors.lastname: Sakata
authors.forename: Kei
authors.initials: K
authors.lastname: Nakashima
authors.forename: Taiyo
authors.initials: T
authors.lastname: Komatsu
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kojima
authors.forename: Aiko
authors.initials: A
authors.lastname: Masunaga
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Fujii
authors.forename: Naoki
authors.initials: N
authors.lastname: Saita
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Kohrogi
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications*; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D008875:Middle Aged; D011112:Polymyxin B / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D016572:Cyclosporine; D003520:Cyclophosphamide; D011112:Polymyxin B