title: Periportal CD4+ cell infiltration increases in HIV/hepatitis C virus-coinfected patients commencing ART, whereas CD8+ cells clear from the liver.
abstract: Coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) is common in Asia, but the effects of antiretroviral therapy (ART) are unclear. Histopathological changes in the liver are described in a prospective study of HCV-seropositive HIV-infected patients at Cipto Mangunkusomo Hospital (Jakarta, Indonesia). Liver biopsy specimens were collected at baseline (n = 48) and 48 weeks (n = 34). Ishak scores showed mild but detectable inflammation and/or fibrosis. Levels of portal inflammation declined during ART (P = .03), whereas fibrosis remained (P = .11). Portal infiltration of CD4(+) cells increased during ART (P < .0001), whereas infiltration of CD8(+) cells subsided. Numbers of CD4(+) cells in the liver at baseline correlated with circulating CD4(+) T-cell counts (P = .03-.05). Numbers of liver-infiltrating CD4(+) and CD8(+) cells at baseline were not associates with subsequent experience of an immune restoration disease, which is defined by a rise in alanine transaminase levels during ART.
authors.affiliation: Department of Internal Medicine, Medical Faculty, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
authors.forename: Rino A
authors.initials: RA
authors.lastname: Gani
authors.affiliation: Department of Internal Medicine, Medical Faculty, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
authors.forename: Evy
authors.initials: E
authors.lastname: Yunihastuti
authors.affiliation: Department of Anatomical Pathology, Medical Faculty, University of Indonesia, Jakarta, Indonesia.
authors.forename: Ening
authors.initials: E
authors.lastname: Krisnuhoni
authors.affiliation: Department of Internal Medicine, Medical Faculty, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
authors.forename: Henny
authors.initials: H
authors.lastname: Saraswati
authors.affiliation: Department of Internal Medicine, Medical Faculty, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
authors.forename: Sjamsurizal
authors.initials: S
authors.lastname: Djauzi
authors.affiliation: Department of Internal Medicine, Medical Faculty, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
authors.forename: Laurentius A
authors.initials: LA
authors.lastname: Lesmana
authors.affiliation: School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Australia Department of Microbiology, Royal Perth Hospital, Perth, Australia.
authors.forename: Silvia
authors.initials: S
authors.lastname: Lee
authors.affiliation: Department of Internal Medicine, Medical Faculty, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Australia.
authors.forename: Patricia
authors.initials: P
authors.lastname: Price
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000502:physiology*; D018414:CD8-Positive T-Lymphocytes / Q000502:physiology*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008099:Liver / Q000166:cytology*; D008297:Male
chemical_list: D019380:Anti-HIV Agents
keywords: HIV; antiretroviral therapy; co-infection hepatitis C; liver pathology