title: [Significance of exhaled nitric oxide measurement in remitting childhood asthma with concurrent remitting rhinitis].
abstract: OBJECTIVE
  To evaluate the value of exhaled nitric oxide in the severity evaluation of asthmatic children with remitting rhinitis.
  
  
  METHODS
  A total of 214 asthmatic children were randomly allocated to a untreated control and a conventional treatment group. Patients in each of the two subclasses were classified as asthma with concurrent rhinitis and asthma without concurrent rhinitis. Values of the 20% fall in forced expiratory volume in 1 second (PC20FEV1) and fractional exhaled nitric oxide (FeNO) were measured.
  
  
  RESULTS
  The PC20FEV1 level was significantly higher in untreated asthma patients without rhinitis than in those with concurrent rhinitis (P<0.05), while FeNO was not significantly different between these two groups (P>0.05). There were no significant differences in both FeNO and PC20FEV1 between treated asthma patients with and without concurrent rhinitis (P>0.05). PC20FEV1 was significantly increased (P<0.05) but FeNO was significantly decreased (P<0.05) in asthma patients with concurrent rhinitis after conventional treatment. In asthmatic children without concurrent rhinitis, treatment significantly decreased the level of FeNO (P<0.05) but had not effect on PC20FEV1 (P>0.05).
  
  
  CONCLUSIONS
  Exhaled nitric oxide measurement may be useful in the severity evaluation of asthmatic children with remitting rhinitis.
authors.affiliation: Department of Respiration, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. lsls2628@126.com.
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.forename: Cai-Hui
authors.initials: CH
authors.lastname: Gong
authors.forename: Zhou
authors.initials: Z
authors.lastname: Fu
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000175:diagnosis*; D001944:Breath Tests; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000032:analysis*; D065631:Rhinitis, Allergic; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis*; D012720:Severity of Illness Index
chemical_list: D009569:Nitric Oxide