title: Regulation of the X chromosomes in Caenorhabditis elegans.
abstract: Dosage compensation, which regulates the expression of genes residing on the sex chromosomes, has provided valuable insights into chromatin-based mechanisms of gene regulation. The nematode Caenorhabditis elegans has adopted various strategies to down-regulate and even nearly silence the X chromosomes. This article discusses the different chromatin-based strategies used in somatic tissues and in the germline to modulate gene expression from the C. elegans X chromosomes and compares these strategies to those used by other organisms to cope with similar X-chromosome dosage differences.
authors.affiliation: Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064.
authors.forename: Susan
authors.initials: S
authors.lastname: Strome
authors.forename: William G
authors.initials: WG
authors.lastname: Kelly
authors.forename: Sevinc
authors.initials: S
authors.lastname: Ercan
authors.forename: Jason D
authors.initials: JD
authors.lastname: Lieb
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004303:Dosage Compensation, Genetic; D005260:Female; D005786:Gene Expression Regulation; D006657:Histones / Q000378:metabolism; D008297:Male; D008957:Models, Genetic; D019849:Sex Determination Processes; D014960:X Chromosome; D049951:X Chromosome Inactivation
chemical_list: D029742:Caenorhabditis elegans Proteins; D006657:Histones