title: Brain-derived neurotrophic factor: its impact upon neuroplasticity and neuroplasticity inducing transcranial brain stimulation protocols.
abstract: Val66Met (rs6265) is a gene variation, a single nucleotide polymorphism (SNP) in the brain-derived neurotrophic factor (BDNF) gene that codes for the protein BDNF. The substitution of Met for Val occurs at position 66 in the pro-region of the BDNF gene and is responsible for altered activity-dependent release and recruitment of BDNF in neurons. This is believed to manifest itself in an altered ability in neuroplasticity induction and an increased predisposition toward a number of neurological disorders. Many studies using neuroplasticity-inducing protocols have investigated the impact of the BDNF polymorphism on cortical modulation and plasticity; however, the results are partly contradictory and dependent on the paradigm used in a given study. The aim of this review is to summarize recent knowledge on the relationship of this BDNF SNP and neuroplasticity.
authors.affiliation: Clinic for Clinical Neurophysiology, University Medical Center, Georg-August University, Robert-Koch-Str. 40, 37075, Göttingen, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Chaieb
authors.forename: A
authors.initials: A
authors.lastname: Antal
authors.forename: G G
authors.initials: GG
authors.lastname: Ambrus
authors.forename: W
authors.initials: W
authors.lastname: Paulus
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D019208:Brain-Derived Neurotrophic Factor / Q000502:physiology*; D002490:Central Nervous System / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006720:Homozygote; D006801:Humans; D007858:Learning; D008568:Memory; D008715:Methionine / Q000737:chemistry; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D013569:Synapses / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D014633:Valine / Q000737:chemistry
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine