title: Determination of carbohydrate-deficient transferrin in a Han Chinese population.
abstract: BACKGROUND
  Carbohydrate-deficient transferrin (CDT) is a widely used alcohol biomarker. Because of the high prevalence of chronic alcohol abuse in many countries, CDT plays an important role in the areas of traffic, clinical, and forensic medicine. However, CDT levels have not been determined in the Han Chinese population. Therefore, we investigated the frequency of genetic transferrin variants and the relationship between CDT levels and alcohol consumption in this population. From this data, we established a CDT cut-off for Han Chinese and evaluated the analytical performance of the CDT capillary zone electrophoresis system.
  
  
  RESULTS
  The prevalence of transferrin variants was 4.14%. The mean CDT level of the reference group was 0.73%. We recommended CDT level >1.5% as cut off standard of alcohol intake to ensuring the specificity was best. The CDT test total precision for 0.5%, 0.7%, and 1.55% was 14.4%, 11.5%, and 7.2%, respectively. The data showed good linearity in the studied range of 0.6% to 8.2%.
  
  
  CONCLUSIONS
  These results demonstrate that CDT is a useful marker to detect heavy daily alcohol consumption. We proposed and evaluated the first CDT cut-off for the Han Chinese population, and we showed that the CDT capillary zone electrophoresis system is a reliable analytic method.
authors.forename: Binbin
authors.initials: B
authors.lastname: Song
authors.forename: Jing
authors.initials: J
authors.lastname: Zhu
authors.forename: Jiong
authors.initials: J
authors.lastname: Wu
authors.forename: Chunyan
authors.initials: C
authors.lastname: Zhang
authors.forename: Beili
authors.initials: B
authors.lastname: Wang
authors.forename: Baishen
authors.initials: B
authors.lastname: Pan
authors.affiliation: Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China. guo.wei@zs-hospital.sh.cn.
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002681:China; D019075:Electrophoresis, Capillary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012015:Reference Standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012737:Sex Factors; D014168:Transferrin / Q000031:analogs & derivatives* / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: D015415:Biomarkers; D014168:Transferrin; C056759:carbohydrate-deficient transferrin