title: Successful treatment of an infant infected with refractory C. parapsilosis with caspofungin.
abstract: Neonatal Candida infections are the leading cause of invasive fungal infections that might cause severe morbidity or mortality in a large majority of those affected. Although Candida albicans has been the most common species, Candida parapsilosis is increasingly being recognized as an important cause of invasive candidiasis in neonates. Among the Candida species, C. parapsilosis has been commonly isolated and shown to be less susceptible in vitro to echinocandins than other Candida species. We report an infant who had refractory C. parapsilosis septicemia cured with caspofungin.
authors.affiliation: Ankara Hematology Oncology Children's Training and Research Hospital, Pediatric Infectious Disease Unit, Ankara, Turkey aslinur.o@gmail.com.
authors.forename: Aslınur
authors.initials: A
authors.lastname: Ozkaya-Parlakay
authors.affiliation: Gazi University Faculty of Medicine Pediatric Infectious Diseases Unit, Ankara, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Tezer
authors.affiliation: Ankara Hematology Oncology Children's Training and Research Hospital, Neonatology Unit, Ankara, Turkey.
authors.forename: Tugba
authors.initials: T
authors.lastname: Kazmacan
authors.affiliation: Ankara Hematology Oncology Children's Training and Research Hospital, Pediatric Infectious Disease Unit, Ankara, Turkey.
authors.forename: Belgin
authors.initials: B
authors.lastname: Gulhan
authors.affiliation: Ankara Hematology Oncology Children's Training and Research Hospital, Neonatology Unit, Ankara, Turkey.
authors.forename: Sevim
authors.initials: S
authors.lastname: Unal
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000151:congenital / Q000188:drug therapy* / Q000382:microbiology; D000077336:Caspofungin; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000382:microbiology; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin
keywords: Candida parapsilosis; caspofungin; infant