title: Tubulin polymerization promoting protein 1 (TPPP1): A DNA-damage induced microtubule regulatory gene.
abstract: The eukaryotic cell cycle relies heavily on the mechanical forces vested by the dynamic rearrangement of the microtubule (MT) network. Tubulin Polymerization promoting Protein 1 (TPPP1) alters MT dynamics by driving MT polymerization as well as stabilization, via increasing MT acetylation. It increases MT rigidity, which results in reduced cell proliferation through downregulation of G1/S-phase and mitosis to G1-phase cell cycle transitioning. In this communication, we provide further evidence that TPPP1 may be an important regulator of genomic homeostasis. Our preliminary data show that long-term TPPP1 overexpression reduces cell viability via induction of apoptotic cell death pathways. Moreover, induction of DNA-damage results in increased TPPP1 expression, which is inhibited in the absence of expression of the tumor suppressor p53.
authors.affiliation: Cytoskeleton and Cancer Unit; St Vincent's Institute of Medical Research; Department of Medicine (St. Vincent's Hospital); University of Melbourne; Melbourn VIC Australia.
authors.forename: Alice
authors.initials: A
authors.lastname: Schofield
authors.affiliation: Cytoskeleton and Cancer Unit; St Vincent's Institute of Medical Research; Department of Medicine (St. Vincent's Hospital); University of Melbourne; Melbourn VIC Australia.
authors.forename: Ora
authors.initials: O
authors.lastname: Bernard
keywords: Cdk; Cell cycle; HDAC6; ROCK; TPPP1; p53; signal transduction