title: Dietary influence on urinary excretion of 3-deoxyglucosone and its metabolite 3-deoxyfructose.
abstract: 3-Deoxyglucosone (3-DG), a reactive 1,2-dicarbonyl compound derived from d-glucose in food and in vivo, is an important precursor for advanced glycation endproducts (AGEs). At present, virtually no information about the metabolic transit of dietary 3-DG is available. One possible metabolic pathway of 3-DG during digestion is enzymatic transformation to less reactive compounds such as 3-deoxyfructose (3-DF). To study the handling of dietary 1,2-dicarbonyl compounds by the human body, 24 h urinary excretion of 3-DG and its metabolite, 3-deoxyfructose, was investigated. Urinary 3-DG and 3-DF excretion was monitored for nine healthy volunteers following either a diet with no dietary restrictions or a diet avoiding the ingestion of 3-DG and other Maillard reaction products ("raw food" diet). During the "raw food" diet, the urinary 3-DG and 3-DF excretion decreased approximately to 50% compared to the excretions during the diet with no restrictions. When subjects received a single dose of wild honey (50 g) naturally containing a defined amount of 3-DG (505 μmol), median excretion of 3-DG and 3-DF increased significantly from 4.6 and 77 to 7.5 and 147 μmol/day, respectively. The obtained experimental data for the first time demonstrate a dietary influence on urinary 3-DG and 3-DF levels in healthy human subjects.
authors.affiliation: Institute of Food Chemistry, Technische Universität Dresden , D-01062 Dresden, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Degen
authors.forename: Helene
authors.initials: H
authors.lastname: Beyer
authors.forename: Björn
authors.initials: B
authors.lastname: Heymann
authors.forename: Michael
authors.initials: M
authors.lastname: Hellwig
authors.forename: Thomas
authors.initials: T
authors.lastname: Henle
mesh_terms: D000328:Adult; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D004032:Diet; D004063:Digestion; D005260:Female; D006722:Honey / Q000032:analysis; D006801:Humans; D007661:Ketoses / Q000378:metabolism*; D008297:Male; D055815:Young Adult
chemical_list: D007661:Ketoses; C068286:3-deoxyhexulose; D003847:Deoxyglucose; C016350:3-deoxyglucosone