title: Who needs cerebrospinal biomarkers? A national survey in clinical practice.
abstract: Cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) are well validated in clinical research but less in clinical practice. Using a questionnaire, we evaluated the reasons for prescriptions and clinician's expectations concerning CSF biomarkers. The results show that CSF AD biomarkers are mainly required in case of atypical dementia and diagnosis uncertainty that are different from indications in clinical research. In the future, clinicians wish to get new biomarkers that could improve differential diagnosis and could have a good pronostic value. Further studies in routine practice are necessary to precise the role of these biomarkers in the management of patients.
authors.affiliation: Research Memory Center University Hospital Lille Nord de France, UDSL, Lille, France.
authors.forename: Anne Cécile
authors.initials: AC
authors.lastname: Troussière
authors.affiliation: Research Memory Center, Neurology Department and INSERM UMR1079, Rouen University Hospital, Rouen, France.
authors.forename: David
authors.initials: D
authors.lastname: Wallon
authors.affiliation: INSERM U942, Paris, France Department of Histology, Lariboisière Fernand Widal Saint Louis Hospital, APHP, University of Paris Diderot, Paris, France Institut du Fer à Moulin Inserm UMR S839, Paris, France.
authors.forename: François
authors.initials: F
authors.lastname: Mouton-Liger
authors.affiliation: Research Memory Center EA COBTEK, University Hospital of Nice Sophia Antipolis, France.
authors.forename: Rachida
authors.initials: R
authors.lastname: Yatimi
authors.affiliation: Research Memory Center EA COBTEK, University Hospital of Nice Sophia Antipolis, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Robert
authors.affiliation: INSERM U942, Paris, France Department of Histology, Lariboisière Fernand Widal Saint Louis Hospital, APHP, University of Paris Diderot, Paris, France Research Memory Center, Lariboisière FW Saint-Louis Hospital, APHP, University of Paris Diderot, Paris, France.
authors.forename: Jacques
authors.initials: J
authors.lastname: Hugon
authors.affiliation: Research Memory Center, Neurology Department and INSERM UMR1079, Rouen University Hospital, Rouen, France.
authors.forename: Didier
authors.initials: D
authors.lastname: Hannequin
authors.affiliation: Research Memory Center University Hospital Lille Nord de France, UDSL, Lille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.affiliation: INSERM U942, Paris, France Department of Histology, Lariboisière Fernand Widal Saint Louis Hospital, APHP, University of Paris Diderot, Paris, France Research Memory Center, Lariboisière FW Saint-Louis Hospital, APHP, University of Paris Diderot, Paris, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Paquet
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid*; D003704:Dementia / Q000134:cerebrospinal fluid*; D003937:Diagnosis, Differential; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers
keywords: Alzheimer's disease; biomarkers; cerebrospinal fluid; clinical practice