title: Space maintenance using crosslinked collagenated porcine bone grafted without a barrier membrane in one-wall intrabony defects.
abstract: The aim of this study was to determine the efficacy of crosslinked collagenated porcine bone (CPB) for the repair of surgically prepared one-wall intrabony defects in dogs. Buccolingually opened, one-wall, box-type periodontal defects (4 × 5 mm) were prepared bilaterally at the mesial side of the mandibular fourth premolars in beagle dogs (N = 5). Block-type CPB (4 × 5 × 5 mm) was placed on either the left or right side for the CPB site; the opposite site served as a sham-surgery control. Micro-computed tomographic and histological analyses were performed on block specimens obtained from the dogs after a 3-month healing period. There was less mean bone regeneration and cementum regeneration at the experimental sites than at the sham-surgery control sites. Most of the porcine bone particles were located under the floor of the defect and were sequestered from pristine bone. These findings show that CPB can be localized within the defect during the wound-healing period by a process of crosslinking; however, the application of CPB alone without a barrier membrane may not be effective in promoting periodontal regeneration in noncontained-type defects.
authors.affiliation: Department of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Korea; Department of Periodontics, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
authors.forename: Jung-Im
authors.initials: JI
authors.lastname: Park
authors.forename: Cheryl
authors.initials: C
authors.lastname: Yang
authors.forename: Young-Taek
authors.initials: YT
authors.lastname: Kim
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Seong-Ho
authors.initials: SH
authors.lastname: Choi
authors.forename: Ui-Won
authors.initials: UW
authors.lastname: Jung
mesh_terms: D000818:Animals; D001641:Bicuspid / Q000000981:diagnostic imaging / Q000293:injuries* / Q000601:surgery*; D001705:Bioprosthesis; D001861:Bone Regeneration; D003094:Collagen / Q000737:chemistry; D004285:Dogs; D008334:Mandible / Q000000981:diagnostic imaging / Q000601:surgery; D010519:Periodontium / Q000000981:diagnostic imaging / Q000293:injuries* / Q000601:surgery*; D011859:Radiography; D013552:Swine
chemical_list: D003094:Collagen
keywords: crosslinked collagen; dog; one-wall defect; periodontal regeneration; porcine bone