title: Tranexamic acid decreases blood loss during transurethral resection of the prostate (TUR -P).
abstract: BACKGROUND
  Postoperative blood loss after prostate surgery is thought to be associated with an increase in urinary fibrinolytic activity. Tranexamic acid (TXA) is both a potent inhibitor of plasminogen and urokinase activators and a low molecular weight substance that is excreted unchanged in the urinary tract and can be administered both orally and intravenously. We investigated the effect of TXA on the amount of blood loss during transurethral resection of the prostate (TURP).
  
  
  METHODS
  Forty patients with registry numbers ending in even numbers were allocated to the treatment group; those ending in odd numbers were used as controls and received no treatment. The treatment group received 10 mg/kg TXA by intravenous infusion during the first half hour of the operation, while the control group of patients received no medication. Serum hemoglobin was measured before and after surgery. The volume and hemoglobin concentration of the irrigation fluid, resected prostate weight, and duration of resection were recorded.
  
  
  RESULTS
  The mean loss of hemoglobin per gram of resected prostate tissue was 1.25 g in the TXA group and 2.84 g in the control group. Total hemoglobin loss in the irrigating fluid and hemoglobin loss per 1 gram of prostate tissue was lower in the group of patients given TXA than in the control group (p = 0.018 and p <0.001).
  
  
  CONCLUSIONS
  Reduced bleeding during TURP as a result of TXA treatment may lead to better surgical conditions and, as a consequence, shorter operative times and lower irrigating fluid volumes.
authors.affiliation: Sakarya Training and Research Hospital, Department of Urology, Sakarya, Turkey.
authors.forename: Sükrü
authors.initials: S
authors.lastname: Kumsar
authors.affiliation: Başkent University, School of Medicine, Department of Urology, Ankara, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dirim
authors.affiliation: Başkent University, School of Medicine, Department of Urology, Ankara, Turkey.
authors.forename: Serdar
authors.initials: S
authors.lastname: Toksöz
authors.affiliation: Sakarya University, School of Medicine, Department of Urology, Sakarya, Turkey.
authors.forename: Hasan S
authors.initials: HS
authors.lastname: Sağlam
authors.affiliation: Sakarya University, School of Medicine, Department of Urology, Sakarya, Turkey.
authors.forename: Oztuğ
authors.initials: O
authors.lastname: Adsan
keywords: prostate; prostatic hyperplasia; tranexamic acid; transurethral resection of the prostate