title: [fMRI study of the dominant hemisphere for language in patients with brain tumor].
abstract: Paper describes a study of language lateralization of patients with brain tumors, measured by preoperative functional magnetic resonance imaging (fMRI) and comparison results with tumor histology and profile of functional asymmetry.
  
  
  
  During the study 21 patient underwent fMRI scan. 15 patients had a tumor in the left and 6 in the right hemisphere. Tumors were localized mainly in the frontal, temporal and fronto-temporal regions. Histological diagnosis in 8 cases was malignant Grade IV, in 13 cases--Grade I-III. fMRI study was perfomed on scanner "Signa Exite" with a field strength of 1.5 As speech test reciting the months of the year in reverse order was used. fMRI scan results were compared with the profile of functional asymmetry, which was received with the results of questionnaire Annette and dichotic listening test.
  
  
  
  Broca's area was found in 7 cases in the left hemisphere, 6 had a tumor Grade I-III. And one patient with glioblastoma had a tumor of the right hemisphere. Broca's area in the right hemisphere was found in 3 patients (2 patients with left sided tumor, and one with right-sided tumor). One patient with left-sided tumor had mild motor aphasia. Bilateral activation in both hemispheres of the brain was observed in 6 patients. All of them had tumor Grade II-III of the left hemisphere. Signs of left-handedness were revealed only in half of these patients. Broca's area was not found in 4 cases. All of them had large malignant tumors Grade IV. One patient couldn't handle program of the research.
  
  
  
  Results of fMRI scans, questionnaire Annette and dichotic listening test frequently were not the same, which is significant. Bilateral activation in speech-loads may be a reflection of brain plasticity in cases of long-growing tumors. Thus it's important to consider the full range of clinical data in studying the problem of the dominant hemisphere for language.
authors.forename: S B
authors.initials: SB
authors.lastname: Buklina
authors.forename: A E
authors.initials: AE
authors.lastname: Podoprigora
authors.forename: I N
authors.initials: IN
authors.lastname: Pronin
authors.forename: L V
authors.initials: LV
authors.lastname: Shishkina
authors.forename: G N
authors.initials: GN
authors.lastname: Boldyreva
authors.forename: A A
authors.initials: AA
authors.lastname: Bondarenko
authors.forename: L M
authors.initials: LM
authors.lastname: Fadeeva
authors.forename: V N
authors.initials: VN
authors.lastname: Kornienko
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Zhukov
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011859:Radiography