title: [Morpho-functional characteristics of conducting airways and the respiratory portion of rat lung under the conditions of intratracheal infection from the positions of the neuroendocrine regulation of reparative histogeneses].
abstract: With the use of light and electron microscopy and immunohistochemistry, the morpho-functional changes in the lungs, the hypothalamus and the neurohypophysis were studied in 45 outbred albino male rats 1, 3, 7 and 14 days after the intratracheal infusion of Staphylococcus aureus strains either possessing anti-lactoferrin activity (ALfA(+)) or lacking it (ALfA(-)). After the infusion of ALfA(+) bacteria, the bronchial wall and the respiratory portion of the lungs demonstrated the destructive changes of tissues, sclerosis phenomena, disturbances of regeneration processes (polypoid outgrowth, metaplasia), while in the neurohypophysis a delay in the release of neurosecretion into the blood from the terminals of nonapeptidergic neurosecretory cells took place. These phenomena were not observed after the infection with ALfA(-)bacteria. The results obtained indicate the disturbances of the structural-functional homeostasis of pulmonary tissues associated with bacterial ALfa, taking place together with the limitations of the hypothalamic neurosecretion.
authors.forename: E M
authors.initials: EM
authors.lastname: Vakhitov
authors.forename: I V
authors.initials: IV
authors.lastname: Labutin
authors.forename: A N
authors.initials: AN
authors.lastname: Kozlova
authors.forename: R V
authors.initials: RV
authors.lastname: Beznosik
mesh_terms: D000818:Animals; D001980:Bronchi / Q000378:metabolism / Q000382:microbiology / Q000648:ultrastructure; D006706:Homeostasis; D007031:Hypothalamus / Q000378:metabolism / Q000648:ultrastructure; D007781:Lactoferrin / Q000235:genetics*; D008168:Lung / Q000378:metabolism / Q000382:microbiology / Q000648:ultrastructure*; D008297:Male; D009490:Neurosecretory Systems / Q000382:microbiology / Q000473:pathology; D010904:Pituitary Gland, Posterior / Q000378:metabolism / Q000382:microbiology / Q000473:pathology / Q000648:ultrastructure*; D051381:Rats; D013211:Staphylococcus aureus / Q000235:genetics / Q000472:pathogenicity*
chemical_list: D007781:Lactoferrin