title: Acute cardiotoxic effects of adjuvant trastuzumab treatment and its relation to oxidative stress.
abstract: Our aim was to evaluate the acute cardiac toxicity of adjuvant trastuzumab treatment and its possible relation to changes in oxidative stress. Electrocardiographic and echocardiographic tissue Doppler imaging (TDI) parameters, activity of antioxidant enzymes (superoxide dismutase; SOD), and products of oxidative stress (malondialdehyde; MDA) were analyzed in 30 patients with early-stage breast cancer who had adjuvant trastuzumab treatment. There was a significant prolongation of QT interval after trastuzumab treatment. There was also a significant decrease in left ventricular ejection fraction (LVEF), TDI-derived S' parameters, and SOD enzyme activity and increase in MDA levels after trastuzumab infusion. There was a positive correlation between changes in SOD activity and LVEF and a negative correlation between changes in MDA levels and LVEF. This study demonstrated a correlation between decreases in LVEF and increases in products of the oxidative stress in patients who had adjuvant trastuzumab treatment.
authors.affiliation: Department of Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Medical Oncology Clinic, Izmir, Turkey ahmetdirican@yahoo.com.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dirican
authors.affiliation: Department of Cardiology, Izmir Katip Celebi University Ataturk Education and Research Hospital, Izmir, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Levent
authors.affiliation: Department of Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Medical Oncology Clinic, Izmir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alacacioglu
authors.affiliation: Department of Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Medical Oncology Clinic, Izmir, Turkey.
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Kucukzeybek
authors.affiliation: Department of Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Medical Oncology Clinic, Izmir, Turkey.
authors.forename: Umut
authors.initials: U
authors.lastname: Varol
authors.affiliation: Department of Cardiology, Izmir Katip Celebi University Ataturk Education and Research Hospital, Izmir, Turkey.
authors.forename: Ugur
authors.initials: U
authors.lastname: Kocabas
authors.affiliation: Department of Cardiology, Izmir Katip Celebi University Ataturk Education and Research Hospital, Izmir, Turkey.
authors.forename: Oktay
authors.initials: O
authors.lastname: Şenöz
authors.affiliation: Department of Cardiology, Izmir Katip Celebi University Ataturk Education and Research Hospital, Izmir, Turkey.
authors.forename: Sadık Volkan
authors.initials: SV
authors.lastname: Emren
authors.affiliation: Department of Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Medical Oncology Clinic, Izmir, Turkey.
authors.forename: Lutfiye
authors.initials: L
authors.lastname: Demir
authors.affiliation: Internal Medicine, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Eyup
authors.initials: E
authors.lastname: Coban
authors.affiliation: Department of Biochemistry, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Saliha
authors.initials: S
authors.lastname: Aksun
authors.affiliation: Department of Biochemistry, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Recep
authors.initials: R
authors.lastname: Sutcu
authors.affiliation: Department of Oncology, Dokuz Eylul University, Institute of Oncology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.
authors.forename: Mustafa Oktay
authors.initials: MO
authors.lastname: Tarhan
mesh_terms: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D001943:Breast Neoplasms; D005260:Female; D006331:Heart Diseases; D006801:Humans; D000068878:Trastuzumab; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068878:Trastuzumab
keywords: acute cardiotoxicity; oxidative stress; trastuzumab