title: Helicobacter pylori-related chronic gastritis as a risk factor for colonic neoplasms.
abstract: To summarize the current views and insights on associations between Helicobacter pylori (H. pylori)-related chronic gastritis and colorectal neoplasm, we reviewed recent studies to clarify whether H. pylori infection/H. pylori-related chronic gastritis is associated with an elevated risk of colorectal neoplasm. Recent studies based on large databases with careful control for confounding variables have clearly demonstrated an increased risk of colorectal neoplasm associated with H. pylori infection. The correlation between H. pylori-related chronic atrophic gastritis (CAG) and colorectal neoplasm has only been examined in a limited number of studies. A recent large study using a national histopathological database, and our study based on the stage of H. pylori-related chronic gastritis as determined by serum levels of H. pylori antibody titer and pepsinogen, indicated that H. pylori-related CAG confers an increased risk of colorectal neoplasm, and more extensive atrophic gastritis will probably be associated with even higher risk of neoplasm. In addition, our study suggested that the activity of H. pylori-related chronic gastritis is correlated with colorectal neoplasm risk. H. pylori-related chronic gastritis could be involved in an increased risk of colorectal neoplasm that appears to be enhanced by the progression of gastric atrophy and the presence of active inflammation.
authors.affiliation: Izumi Inoue, Jun Kato, Hideyuki Tamai, Mikitaka Iguchi, Takao Maekita, Masao Ichinose, the Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan.
authors.forename: Izumi
authors.initials: I
authors.lastname: Inoue
authors.affiliation: Izumi Inoue, Jun Kato, Hideyuki Tamai, Mikitaka Iguchi, Takao Maekita, Masao Ichinose, the Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kato
authors.affiliation: Izumi Inoue, Jun Kato, Hideyuki Tamai, Mikitaka Iguchi, Takao Maekita, Masao Ichinose, the Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tamai
authors.affiliation: Izumi Inoue, Jun Kato, Hideyuki Tamai, Mikitaka Iguchi, Takao Maekita, Masao Ichinose, the Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan.
authors.forename: Mikitaka
authors.initials: M
authors.lastname: Iguchi
authors.affiliation: Izumi Inoue, Jun Kato, Hideyuki Tamai, Mikitaka Iguchi, Takao Maekita, Masao Ichinose, the Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Maekita
authors.affiliation: Izumi Inoue, Jun Kato, Hideyuki Tamai, Mikitaka Iguchi, Takao Maekita, Masao Ichinose, the Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan.
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimura
authors.affiliation: Izumi Inoue, Jun Kato, Hideyuki Tamai, Mikitaka Iguchi, Takao Maekita, Masao Ichinose, the Second Department of Internal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City, Wakayama 641-0012, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Ichinose
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003110:Colonic Neoplasms / Q000150:complications / Q000382:microbiology*; D018450:Disease Progression; D005756:Gastritis / Q000150:complications / Q000382:microbiology*; D016481:Helicobacter Infections / Q000382:microbiology*; D016480:Helicobacter pylori; D006801:Humans; D007249:Inflammation / Q000382:microbiology; D020116:Pepsinogen A / Q000097:blood; D012307:Risk Factors
chemical_list: D020116:Pepsinogen A
keywords: Atrophic gastritis; Cancer risk; Colorectal neoplasm; Helicobacter pylori antibody; Pepsinogen