title: Inflammatory mediators of endothelial injury in sickle cell disease.
abstract: Inflammation plays a critical role in the complex pathophysiology of sickle cell disease and drives both the acute and chronic processes leading to vascular injury. Mediators of inflammation, such as cellular adhesion molecules, cytokines, leukotrienes, and nuclear factor κB signaling factors, represent potential therapeutic targets in sickle cell disease.
authors.affiliation: Department of Hematology-Oncology, Children's Hospital & Research Center Oakland, 747 52nd Street, Oakland, CA 94609, USA. Electronic address: choppe@mail.cho.org.
authors.forename: Carolyn C
authors.initials: CC
authors.lastname: Hoppe
mesh_terms: D000755:Anemia, Sickle Cell / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors / Q000378:metabolism; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015289:Leukotrienes / Q000378:metabolism; D058990:Molecular Targeted Therapy / Q000379:methods; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D015815:Cell Adhesion Molecules; D016207:Cytokines; D018836:Inflammation Mediators; D015289:Leukotrienes; D016328:NF-kappa B
keywords: Inflammation; Mediators; Sickle cell