title: Exploring the role of SlrR and SlrA in the SinR epigenetic switch.
abstract: biofilms form dental plaque, coat ships causing biofouling, and cling onto medical instruments and implants. Understanding how these surface-bound communities are formed is crucial for the development of suitable strategies for their dispersal. At the heart of a switch that commits Bacilli and related species to form biofilms is a transcriptional regulator called SinR and its multiple antagonists. In this addendum, we discuss an alternative model to account for how one of the antagonists is regulated by controlled proteolysis.
authors.affiliation: Structural Genomics Consortium; Nuffield Department of Clinical Medicine; University of Oxford; Oxford, UK ; Institute for Cell and Molecular Biosciences; University of Newcastle; Newcastle upon Tyne, UK.
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Newman
authors.affiliation: Institute for Cell and Molecular Biosciences; University of Newcastle; Newcastle upon Tyne, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Lewis
keywords: Bacillus; SinR; adaptive responses; biofilm; protein interactions; transcriptional repression