title: A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships.
abstract: This article proposes a new multiple-testing approach for estimation of the minimum effective dose allowing for non-monotonous dose-response shapes. The presented approach combines the advantages of two commonly used methods. It is shown that the new approach controls the error rate of underestimating the true minimum effective dose. Monte Carlo simulations indicate that the proposed method outperforms alternative methods in many cases and is only marginally worse in the remaining situations.
authors.affiliation: Baxter Innovations GmbH, Vienna, Austria.
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Wolfsegger
authors.forename: Georg
authors.initials: G
authors.lastname: Gutjahr
authors.forename: Werner
authors.initials: W
authors.lastname: Engl
authors.forename: Thomas
authors.initials: T
authors.lastname: Jaki
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods*; D003198:Computer Simulation; D006224:Cricetinae; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015233:Models, Statistical; D009152:Mutagenicity Tests / Q000379:methods; D019055:No-Observed-Adverse-Effect Level
keywords: Dose finding; Familywise error rate; Minimum effective dose; Multiple comparisons; Non-monotone shapes; Stepwise testing procedures