title: [Value of diffusion-weighted imaging in diagnosis of lymph node metastasis in patients with cervical cancer].
abstract: OBJECTIVE
  To investigate the value of diffusion-weighted imaging (DWI) in the differentiation of metastatic lymph nodes from non-metastatic lymph nodes in cervical cancer.
  
  
  METHODS
  In 65 patients who underwent lymph node dissection for cervical cancer, conventional MRI and DWI examinations were performed before surgery. Of the 1590 total dissected pelvic lymph nodes, 392 enlarged nodes with a short-axis diameter (S )of 5 mm or greater were included for further analysis. Each of the size-based criteria [i.e., S, long-axis diameter (L), and S/L ratio] and apparent diffusion coefficient(ADC)-based criteria (i.e., ADCmin, ADCmean, rADCmin, rADCmean) were compared between metastatic lymph nodes and non-metastatic lymph nodes.
  
  
  RESULTS
  There were statistically significant differences between metastatic and non-metastatic lymph nodes in S, L, S/L ratio, ADCmin, ADCmean, rADCmin, and rADCmean (all P<0.0001). The Az of the ADCmin (0.956) was greater than that of the other ADC-based criteria and all size-based criteria. Using ADCmin=759.0×10(-6) mm(2)/s, the sensitivity and specificity for differentiating metastatic from non-metastatic lymph nodes were 95.2% and 92.1%, respectively.
  
  
  CONCLUSIONS
  DWI, particularly ADCmin, is feasible for differentiating metastatic from non-metastatic pelvic lymph nodes in patients with cervical cancer.
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Cui
authors.initials: C
authors.lastname: Ren
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Hua-dan
authors.initials: HD
authors.lastname: Xue
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Hai-long
authors.initials: HL
authors.lastname: Zhou
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Zhao-yong
authors.initials: ZY
authors.lastname: Sun
authors.affiliation: Department of Radiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Zheng-yu
authors.initials: ZY
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000175:diagnosis*; D008875:Middle Aged; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000473:pathology*