title: Nitroepoxides as versatile precursors to 1,4-diamino heterocycles.
abstract: Nitroepoxides are easily transformed into 1,4-diamino heterocycles such as quinoxalines and pyrazines by treatment with 1,2-benzenediamines and ammonia, respectively. Additionally, related saturated heterocycles, such as piperazines and tetrahydroquinoxalines, can be accessed by treatment with 1,2-diamines and a reducing agent. These transformations are efficient, provide access privileged, bioactive structures, and produce minimal waste.
authors.affiliation: Departament de Química Inorgànica i Orgànica, Universitat Jaume I , Castelló, Spain.
authors.forename: Andreu
authors.initials: A
authors.lastname: Vidal-Albalat
authors.forename: Santiago
authors.initials: S
authors.lastname: Rodríguez
authors.forename: Florenci V
authors.initials: FV
authors.lastname: González
mesh_terms: D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003959:Diamines; D004852:Epoxy Compounds; D009574:Nitro Compounds; D010879:Piperazines; D011719:Pyrazines; D011810:Quinoxalines