title: Kinetic control in the CID-induced elimination of H3PO4 from phosphorylated serine probed using IRMPD spectroscopy.
abstract: InfraRed Multiple Photon Dissociation (IRMPD) spectroscopy was used to assay the structural features of the fragment ions resulting from the elimination of H3PO4 in the Collision-Induced Dissociation (CID) of protonated serine. The results are interpreted with the aid of density functional theory calculations. Experiment and theory point to an aziridine-ring structure, implying participation of the vicinal amino group in the formation of this species. This finding constitutes a benchmark for investigating the same process in the CID of phosphorylated peptides.
authors.affiliation: Manchester Institute of Biotechnology, School of Chemistry, University of Manchester, 131 Princess Street, M17DN Manchester, UK. francesco.lanucara@manchester.ac.uk.
authors.forename: Francesco
authors.initials: F
authors.lastname: Lanucara
authors.forename: Barbara
authors.initials: B
authors.lastname: Chiavarino
authors.forename: Debora
authors.initials: D
authors.lastname: Scuderi
authors.forename: Philippe
authors.initials: P
authors.lastname: Maitre
authors.forename: Simonetta
authors.initials: S
authors.lastname: Fornarini
authors.forename: Maria Elisa
authors.initials: ME
authors.lastname: Crestoni
mesh_terms: D001388:Aziridines / Q000737:chemistry; D007536:Isomerism; D007700:Kinetics; D010756:Phosphoric Acids / Q000737:chemistry*; D010766:Phosphorylation; D011522:Protons; D012694:Serine / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics
chemical_list: D001388:Aziridines; D010756:Phosphoric Acids; D011522:Protons; D012694:Serine; C033132:aziridine; C030242:phosphoric acid