title: Prognostic value of NF-κB, CD9, and VEGF in gastrointestinal stromal tumors.
abstract: OBJECTIVE
  Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal tumors of the gastrointestinal system. We aimed to determine whether nuclear transcription factor κB (NF-κB), CD9 and vascular endothelial growth factor (VEGF) have prognostic value in patients with GIST.
  
  
  METHODS
  Thirty-five patients with GIST, who were diagnosed in the Pathology Department of Erciyes University, were included in the study. Cases were classified based on the 2002 NIH consensus. CD9, VEGF, and NF-κB immunohistochemistry were applied to GIST cases positive for CD117 and CD34, which are used to evaluate GISTs immunohistochemically.
  
  
  RESULTS
  Although there are no statistically significant differences between NF-κB (p = 0.329), CD9 (p = 0.269), and VEGF (p = 0.372) and risk groups, 79.22% of cases that stained positive for NF-κB, 81% of cases that stained positive for CD9, and 80% of cases that stained positive of VEGF were in the high risk group.
  
  
  CONCLUSIONS
  It was found that NF-κB, CD9, and VEGF, which are important in predicting behaviors of other malign tumors, were expressed at high rates in high risk group GISTs. This can be used to determine prognosis with tumor diameter, mitosis rate under 50 BBS, Ki-67 proliferation index and other parameters.
authors.affiliation: Department of Pathology, Kayseri Education and Research Hospital, Kayseri, Turkey.
authors.forename: Arzu
authors.initials: A
authors.lastname: Tasdemir
authors.affiliation: Department of Pathology, Erciyes University Medical School, Kayseri, Turkey.
authors.forename: Isin
authors.initials: I
authors.lastname: Soyuer
authors.affiliation: Department of Radiation Oncology, Kayseri Education and Research Hospital, Kayseri, Turkey.
authors.forename: Dilek
authors.initials: D
authors.lastname: Unal
authors.affiliation: Department of General Surgery, Erciyes University Medical School, Kayseri, Turkey.
authors.forename: Tarik
authors.initials: T
authors.lastname: Artis
keywords: CD9; NF-κB; VEGF; gastrointestinal stromal tumor