title: A new hemostatic clip for endoscopic surgery that can maintain blood flow after clipping.
abstract: OBJECTIVE
  To develop a new hemostatic device for endoscopic surgery that can control the bleeding without completely occluding the bleeding vessel.
  
  
  METHODS
  A hemostatic clip and its applier that can stanch bleeding while maintaining blood flow through the clipped vessel was introduced, and the performance of the proposed clip was evaluated using in vitro and in vivo experiments.
  
  
  RESULTS
  During in vitro experiments, no leakage was found after clipping at cuts made in artificial vessels, and flow was maintained through the clipped artificial vessels. In experiments on rats, all the implanted clips occluded the target vessels successfully, and no bleeding or tissue damage was observed at the operative site after the rats were euthanized on postoperative day 7. In experiments on pigs, bleeding stopped immediately after partial clipping of a damaged vessel, and some amount of blood flow was consistently maintained through the clipped vessel after hemostasis.
  
  
  CONCLUSIONS
  We believe that the proposed hemostatic clip and clip applier can enhance patient safety during laparoscopic surgery.
authors.affiliation: Kyoung Won Nam, In Young Kim, Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South Korea.
authors.forename: Kyoung Won
authors.initials: KW
authors.lastname: Nam
authors.affiliation: Kyoung Won Nam, In Young Kim, Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South Korea.
authors.forename: Sang Bong
authors.initials: SB
authors.lastname: Lee
authors.affiliation: Kyoung Won Nam, In Young Kim, Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South Korea.
authors.forename: In Young
authors.initials: IY
authors.lastname: Kim
authors.affiliation: Kyoung Won Nam, In Young Kim, Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South Korea.
authors.forename: Kwang Gi
authors.initials: KG
authors.lastname: Kim
authors.affiliation: Kyoung Won Nam, In Young Kim, Department of Biomedical Engineering, Hanyang University, Seoul 133-791, South Korea.
authors.forename: Sang Jae
authors.initials: SJ
authors.lastname: Park
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D004867:Equipment Design; D005260:Female; D007084:Iliac Vein / Q000000981:diagnostic imaging / Q000601:surgery; D010535:Laparoscopy / Q000295:instrumentation*; D008297:Male; D008422:Materials Testing; D008953:Models, Anatomic; D023421:Models, Animal; D008955:Models, Cardiovascular; D051381:Rats; D012039:Regional Blood Flow; D013157:Splenic Artery / Q000000981:diagnostic imaging / Q000601:surgery; D013162:Splenic Vein / Q000000981:diagnostic imaging / Q000601:surgery; D013525:Surgical Instruments; D013552:Swine; D013997:Time Factors; D018615:Ultrasonography, Doppler, Color; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging / Q000601:surgery
keywords: Endoscopic surgery; Hemostasis; Hemostatic clip; Laparoscopic surgery; Vessel bleeding