title: Does infliximab prevent colectomy in acute and chronic active ulcerative colitis?
abstract: OBJECTIVE
  The aim of the study was to evaluate clinical response, use of colectomy, and adverse events related to infliximab (IFX) treatment in acute and chronic active ulcerative colitis (UC) in children.
  
  
  METHODS
  Children from 3 centers, who had received IFX for UC, were identified, and patient charts were reviewed retrospectively. Data concerning symptoms, biochemistry, concomitant medical treatment, colectomy, and adverse events were registered.
  
  
  RESULTS
  A total of 45 patients with UC (median age at diagnosis 12 years, interquartile range 10-14) were included, and studied for a median of 15 months (interquartile range 4.5-29) after first IFX infusion. The cumulative 1- and 2-year risks of colectomy were 21% and 26%, respectively. The cumulative 1- and 2-year risks of receiving a new course of systemic corticosteroids were 32% and 48%, respectively. Twenty-one patients (46%) experienced adverse events. Most common were mild infusion reactions, but 3 (7%) had serious adverse events.
  
  
  CONCLUSIONS
  IFX was efficient in preventing colectomy in children with UC. The risk of receiving systemic corticosteroids was lower than that reported in other studies. Most adverse events were mild to moderate and self-limiting.
authors.affiliation: *Department of Paediatrics, Hvidovre University Hospital, Hvidovre †Hans Christian Andersen Children's Hospital, Odense ‡Department of Paediatrics, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Steffen
authors.initials: S
authors.lastname: Dan-Nielsen
authors.forename: Vibeke
authors.initials: V
authors.lastname: Wewer
authors.forename: Anders
authors.initials: A
authors.lastname: Paerregaard
authors.forename: Lars F
authors.initials: LF
authors.lastname: Hansen
authors.forename: Rasmus G
authors.initials: RG
authors.lastname: Nielsen
authors.forename: Aksel
authors.initials: A
authors.lastname: Lange
authors.forename: Christian
authors.initials: C
authors.lastname: Jakobsen
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D000069285:Infliximab; D008297:Male; D012189:Retrospective Studies; D012306:Risk; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D000911:Antibodies, Monoclonal; D005765:Gastrointestinal Agents; D000069285:Infliximab