title: Model identification of a template-directed peptide network for optimization in a continuous reactor.
abstract: The production rate and selectivity of a cross-catalytic peptide network are optimized in a simulated continuous reaction process, under a peptide solubility constraint. The steady state of this open process is not the equilibrium state, and the optimal solution employs diverse cooperative components.
authors.affiliation: School of Chemical & Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Dr. NW, Atlanta, GA 30332, USA. martha.grover@chbe.gatech.edu.
authors.forename: Andres F
authors.initials: AF
authors.lastname: Hernandez
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Wagner
authors.forename: Martha A
authors.initials: MA
authors.lastname: Grover
mesh_terms: D000595:Amino Acid Sequence; D002384:Catalysis; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008962:Models, Theoretical; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D013696:Temperature
chemical_list: D010455:Peptides