title: Taste hedonics influence the disposition of fat by modulating gastric emptying in rats.
abstract: We investigated how preferred and nonpreferred tastes influence the disposition of fat. Adult male Sprague Dawley rats were infused with 5 ml of 20% intralipid through an intragastric catheter and with 0.3 ml of a taste solution through an intraoral catheter. At 120 min postinfusion, plasma concentrations of fat fuels (triglycerides and non-esterified fatty acids) were either unchanged or slightly higher after rats tasted a preferred sweet taste solution (0.125% saccharin +3% glucose) than after they tasted water. They were markedly lower after rats tasted a non-preferred solution-either a bitter solution (0.15% quinine hydrochloride) or a sweet solution that had previously been the conditioned stimulus for lithium-induced taste aversion. The distribution of 14C-triolein mixed with the gastric load was determined at 4 h postinfusion. Rats that received a non-preferred bitter taste had significantly more 14C remaining in the stomach than did those that received a preferred sweet taste. These results suggest that taste hedonics--either unconditioned or conditioned aversive tastes--influence fat disposition by altering gastric emptying.
authors.affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America; Health Care Food Research Laboratories, Kao Corporation, Tokyo, Japan.
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Saitou
authors.affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America.
authors.forename: John N
authors.initials: JN
authors.lastname: Lees
authors.affiliation: Monell Chemical Senses Center, Philadelphia, Pennsylvania, United States of America.
authors.forename: Michael G
authors.initials: MG
authors.lastname: Tordoff
mesh_terms: D000818:Animals; D002241:Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology; D002250:Carbon Radioisotopes / Q000378:metabolism; D002404:Catheterization; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D005746:Gastric Emptying / Q000502:physiology*; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D011803:Quinine / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D013649:Taste / Q000502:physiology*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics*; D014304:Triolein / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D002241:Carbohydrates; D002250:Carbon Radioisotopes; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D014304:Triolein; D011803:Quinine