title: Absence of tissue ingrowth through the textile fabric in a series of explanted clinic stent-grafts.
abstract: Using the retrieved devices from one autopsy and five reoperations, the biocompatibility of explanted Talent stent-grafts was investigated to highlight the capacity of the fabric to act as an effective scaffold to regenerate a blood conduit. The autopsy device was encapsulated both internally and externally, but the capsules did not penetrate through the fabric structure. The reoperation devices showed discrete patches of compact fibrin and irregularly scattered mural thrombi. Positive staining of α-actin, tissue plasminogen activator (tPA), urokinase (uPA), urokinase receptor (uPAR), and urokinase inhibitors (PAI 1, PAI 2, PAI 3, and protease nexin), and D-dimer was more frequently identified in the autopsy sample than in the reoperation samples. This preliminary assessment shows that the stent-graft retrieved during autopsy was better healed than those explanted at reoperation.
authors.affiliation: The Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Heng Yang, Hunan Province, China; Departments of Surgery and Radiology, Laval University and Quebec Biomaterials Institute, Canada.
authors.forename: Dangheng
authors.initials: D
authors.lastname: Wei
authors.affiliation: Departments of Surgery and Radiology, Laval University and Québec Biomaterials Institute, CHUQ, Quebec, QC, Canada.
authors.forename: Robert
authors.initials: R
authors.lastname: Guidoin
authors.affiliation: Department of Anatomy, Histology and Embryology, Medical University of Varna, Varna.
authors.forename: Georgi R
authors.initials: GR
authors.lastname: Marinov
authors.affiliation: Dept. of Surgery and Radiology, Laval University and Quebec Biomaterials Institute, CHUQ, Canada; Key Laboratory of Biorheological Science and Technology, Bioengineering College, Chongqing University, Chongqing, PR China.
authors.forename: Tieying
authors.initials: T
authors.lastname: Yin
authors.affiliation: Departments of Surgery and Radiology, Laval University and Quebec Biomaterials Institute, CHUQ, Quebec, QC, Canada.
authors.forename: Ze
authors.initials: Z
authors.lastname: Zhang
authors.affiliation: Departments of Surgery and Radiology, Laval University and Quebec Biomaterials Institute, CHUQ, Quebec, QC, Canada.
authors.forename: Yvan
authors.initials: Y
authors.lastname: Douville
authors.affiliation: Institute of Anatomy, University Hospital of Cologne, Cologne, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Koebke
authors.affiliation: Department of Clinical Engineering, University of Liverpool, Liverpool UK.
authors.forename: Thien
authors.initials: T
authors.lastname: How
authors.affiliation: Division of Vascular Surgery, University of Calgary, Peter Lougheed Centre, Calgary AB; Departments of Surgery and Radiology, Laval University and Québec Biomaterials Institute, CHUQ, Quebec, QC, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Nutley
authors.affiliation: Institute of Anatomy, University Hospital of Cologne, Cologne, Germany.
authors.forename: Jutta
authors.initials: J
authors.lastname: Knifka
authors.affiliation: Key Laboratory of Textile Science and Technology of Ministry of Education and College of Textiles, Donghua University, Shanghai, PR. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Surgery, Laval University and Quebec Biomaterials Institute, St-Francois d'Assise Hospital, CHUQ, QC Canada; Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.affiliation: Division of Vascular Surgery, University of Calgary, Peter Lougheed Centre, Calgary AB, Canada.
authors.forename: Gregory
authors.initials: G
authors.lastname: Samis
authors.affiliation: Key Laboratory of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, P. R. China.
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.affiliation: Departments of Surgery and Radiology, Laval University and Quebec Biomaterials Institute, CHUQ, Quebec.
authors.forename: Guy
authors.initials: G
authors.lastname: Dionne
authors.affiliation: Departments of Surgery and Radiology, Laval University and Québec Biomaterials Institute, CHUQ, Quebec, QC, Canada.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Gilbert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001807:Blood Vessel Prosthesis; D020878:Device Removal; D005260:Female; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D011091:Polyesters; D015607:Stents; D013927:Thrombosis / Q000473:pathology
chemical_list: D011091:Polyesters; D005337:Fibrin