title: Clinical evaluation of different applications of misoprostol and aglepristone for induction of abortion in bitches.
abstract: The aim of the present study was to compare the clinical and endocrinological effects of different applications of misoprostol (MIS) and aglepristone (AGL) for the induction of abortion in bitches. For this purpose, 28 healthy pregnant bitches from different breeds, ages, body weights (Body weigt, BWs, 10-40 kg), and between Days 25 to 35 of gestation were used. Bitches were randomly assigned to four groups. In group 1 (GI, n = 7), AGL (10 mg/kg BW, s.c. on 2 consecutive days); in group 2 (GII, n = 7), AGL (as in GI), intravaginal MIS (IVag, 200 μg for bitches with ≤20 kg BW, 400 μg for bitches with >20 kg BW, daily intravaginally until completion of abortion); in group 3 (GIII, n = 7), AGL (as in GI), ICVag (as in GII), per os MIS (400 μg for bitches with ≤20 kg BW, 800 μg for bitches with >20 kg BW, daily orally, until completion of abortion); in group 4 (GIV, n = 7), AGL (as in GI), per os MIS (as GIII) were used. Clinical, vaginal, and ultrasonographic examinations were performed daily until abortion was completed. For measurement of serum progesterone, blood samples were collected in all groups immediately after the first AGL administration and every other day until completion of abortion. No statistical differences were found between groups concerning the duration until completion of abortion after treatment (nonsignificant); however, in GII, one bitch completed abortion 2 days after the start of treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, Turkey. Electronic address: rehaagaoglu@mehmetakif.edu.tr.
authors.forename: A R
authors.initials: AR
authors.lastname: Agaoglu
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Ankara, Ankara, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Aslan
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Harran, Sanliurfa, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Emre
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Harran, Sanliurfa, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Korkmaz
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Uludag, Bursa, Turkey.
authors.forename: E S
authors.initials: ES
authors.lastname: Ozdemir Salci
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Kocamuftuoglu
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, University of Uludag, Bursa, Turkey.
authors.forename: K
authors.initials: K
authors.lastname: Seyrek-Intas
authors.affiliation: Centre for Artificial Insemination and Embryo Transfer, University of Veterinary Medicine, Vienna, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Schäfer-Somi
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000494:pharmacology*; D000034:Abortion, Veterinary / Q000139:chemically induced*; D000818:Animals; D004285:Dogs; D004963:Estrenes / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D016595:Misoprostol / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D004963:Estrenes; D016595:Misoprostol; C419063:aglepristone
keywords: Abortion; Aglepristone; Dog; Misoprostol; Pregnancy termination