title: 18F-DOPA, a clinically available PET tracer to study brain inflammation?
abstract: We report 2 cases of suspected low-grade glioma with positive 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET scan, and histological diagnosis of brain inflammation corresponding to an acute disseminated encephalomyelitis (ADEM) and to a neurosarcoidosis. It has been shown that this amino-acid PET radiotracer serves to evaluate tumoral proliferation related to the metabolism of L-amino-acid transporters, and that inflammation may also contribute to the tumoral uptake. This report suggests it may serve to study brain inflammation.
authors.affiliation: From the *APHM, Hôpital de la Timone, Service Central de Biophysique et Médecine Nucléaire, Marseille; †Aix-Marseille Univ, CERIMED, Marseille; ‡APHM, Hôpital de la Timone, Service de Neurochirurgie, Marseille; §APHM, Hôpital de la Timone, Service de Neurologie, Marseille; ¶APHM, Hôpital de la Timone, Service d'Anatomie Pathologique et Neuropathologie, Marseille; and ∥Aix-Marseille Univ, CNRS, UMR7289, INT, Marseille, France.
authors.forename: Quentin
authors.initials: Q
authors.lastname: Sala
authors.forename: Philippe
authors.initials: P
authors.lastname: Metellus
authors.forename: David
authors.initials: D
authors.lastname: Taieb
authors.forename: Elsa
authors.initials: E
authors.lastname: Kaphan
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: Eric
authors.initials: E
authors.lastname: Guedj
mesh_terms: D000328:Adult; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives*; D004660:Encephalitis / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011849:Radioactive Tracers
chemical_list: D011849:Radioactive Tracers; C043437:fluorodopa F 18; D004295:Dihydroxyphenylalanine