title: Highly enantioselective organocatalyzed vinylogous Michael-type reaction for the construction of trifluoromethylated all-carbon quaternary stereocenters.
abstract: The first example of a highly enantioselective vinylogous Michael-type reaction of β,β-disubstituted nitroalkenes is disclosed. A series of biologically important chiral oxindoles, featuring a trifluoromethylated all-carbon quaternary chiral center, were obtained in good yields with excellent enantioselectivities (up to >99% ee).
authors.affiliation: Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University , Lanzhou, 730000, China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Chen
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Wang
authors.forename: Xianxing
authors.initials: X
authors.lastname: Jiang
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Xu
authors.forename: Li
authors.initials: L
authors.lastname: Lin
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D000078183:Oxindoles; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D006845:Hydrocarbons, Fluorinated; D007211:Indoles; D009574:Nitro Compounds; D000078183:Oxindoles; C022960:2-oxindole; D002244:Carbon