title: The Rietveld method as a tool to quantify the amorphous amount of microcrystalline cellulose.
abstract: With the use of X-ray powder diffraction data and the Rietveld method, we verified that both microcrystalline cellulose PH-101 and PH-102 presented differences in the crystallinity degree. The results revealed these samples are semicrystalline in nature and via Rietveld refinements, it was possible, adding a known amount of an internal standard of corundum to the samples, to perform quantitative phase analyses, which allowed us to determine the amorphous amount of the studied samples: 63.7(11) wt % in microcrystalline cellulose PH-101 and 51.0(11) wt % in microcrystalline cellulose PH-102. An important contribution of this work refers to the attempt of using this simple method, permitting to evaluate the degree of crystallinity of microcrystalline cellulose.
authors.affiliation: Centro de Ciências Naturais e Humanas (CCNH), Universidade Federal do ABC (UFABC), Santo André, SP, CEP: 09210-580, Brazil.
authors.forename: Laysa Pires
authors.initials: LP
authors.lastname: De Figueiredo
authors.forename: Fabio Furlan
authors.initials: FF
authors.lastname: Ferreira
mesh_terms: D002482:Cellulose / Q000737:chemistry*; D003460:Crystallization / Q000379:methods; D005079:Excipients / Q000737:chemistry*; D011208:Powders / Q000737:chemistry; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D005079:Excipients; D011208:Powders; D002482:Cellulose; C109691:microcrystalline cellulose
keywords: Rietveld method; FTIR; dehydration; X-ray powder diffraction; crystallinity; microcrystalline cellulose PH-101; microcrystalline cellulose PH-102; solid state