title: Quantitative assessment of the presence and severity of cirrhosis in patients with hepatitis B using right liver lobe volume and spleen size measured at magnetic resonance imaging.
abstract: OBJECTIVE
  To determine whether right liver lobe volume (RV) and spleen size measured utilizing magnetic resonance (MR) imaging could identify the presence and severity of cirrhosis in patients with hepatitis B.
  
  
  METHODS
  Two hundred and five consecutive patients with clinically confirmed diagnosis of cirrhosis due to hepatitis B and 40 healthy control individuals were enrolled in this study and underwent abdominal triphasic enhanced scans using MR imaging. Spleen maximal width (W), thickness (T) and length (L), together with RV and spleen volume (SV), were measured utilizing MR imaging. Spleen multidimensional index (SI) was obtained by multiplying previously acquired parameters W×T×L. Then statistical assessment was performed to evaluate the ability of these parameters, including RV, SV, RV/SV and SI, to identify the presence of cirrhosis and define Child-Pugh class of this disease.
  
  
  RESULTS
  SV and SI tended to increase (r = 0.557 and 0.622, respectively; all P<0.001), and RV and RV/SV tended to decrease (r = -0.749 and -0.699, respectively; all P<0.001) with increasing Child-Pugh class of cirrhosis. All the parameters, including RV, SV, RV/SV and SI, might be the indicators used to discriminate the patients with liver cirrhosis from the control group, and to distinguish these patients between Child-Pugh class A and B, between B and C, and between A and C (area under receiver operating characteristic curve [AUC] = 0.609-0.975, all P<0.05). Among these parameters, RV/SV was the best noninvasive factor for the discrimination of liver cirrhosis between Child-Pugh class A and B (AUC = 0.725), between A and C (AUC = 0.975), and between B and C (AUC = 0.876), while SI was the best variable to distinguish the cirrhosis patients from the control group (AUC = 0.960, P<0.05).
  
  
  CONCLUSIONS
  RV/SV should be used to identify the severity of cirrhosis, while SI can be recommended to determine the presence of this disease.
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China; Department of Radiology, Sichuan Cancer Hospital and Institute & The Second People's Hospital of Sichuan Province, Chengdu, Sichuan, China.
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Chen
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Tian-Wu
authors.initials: TW
authors.lastname: Chen
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhang
authors.affiliation: Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Zhen-Lin
authors.initials: ZL
authors.lastname: Li
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Nan-Lin
authors.initials: NL
authors.lastname: Zeng
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.affiliation: Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
authors.forename: Zhi-Jia
authors.initials: ZJ
authors.lastname: Fang
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Ultrasonography, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.affiliation: Department of Radiology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.affiliation: Department of Radiology, Sichuan Cancer Hospital and Institute & The Second People's Hospital of Sichuan Province, Chengdu, Sichuan, China.
authors.forename: Guo-Hui
authors.initials: GH
authors.lastname: Xu
authors.affiliation: Department of Radiology, Sichuan Cancer Hospital and Institute & The Second People's Hospital of Sichuan Province, Chengdu, Sichuan, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Ren
authors.affiliation: Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
authors.forename: Jian-Lin
authors.initials: JL
authors.lastname: Wu
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, and Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
authors.forename: Chun-Ping
authors.initials: CP
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D064368:Healthy Volunteers; D006509:Hepatitis B / Q000150:complications* / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D009929:Organ Size; D012372:ROC Curve; D013154:Spleen / Q000473:pathology*