title: Diabetes. Solving human β-cell development--what does the mouse say?
abstract: A genetic analysis of patients with permanent neonatal diabetes mellitus has revealed functional conservation of transcription factors critical for β-cell development in both mouse and man. This finding supports the use of mice for modelling human disease but also highlights the need for additional human-specific studies of β-cell function.
authors.affiliation: Diabetes Center, Department of Medicine, University of California-San Francisco, 513 Parnassus Avenue, HSW 1116, Box 0540, San Francisco, CA 94143, USA.
authors.forename: Alexandra E
authors.initials: AE
authors.lastname: Folias
authors.affiliation: Diabetes Center, Department of Medicine, University of California-San Francisco, 513 Parnassus Avenue, HSW 1116, Box 0540, San Francisco, CA 94143, USA.
authors.forename: Matthias
authors.initials: M
authors.lastname: Hebrok
mesh_terms: D000818:Animals; D003920:Diabetes Mellitus / Q000235:genetics*; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics*; D010179:Pancreas / Q000254:growth & development* / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors