title: N-Heterocyclic carbene-catalyzed formal cross-coupling reaction of α-haloenals with thiols: organocatalytic construction of sp2 carbon-sulfur bonds.
abstract: A novel N-heterocyclic carbene (NHC)-catalyzed formal cross-coupling reaction between α-haloenals and thiols was developed. In the presence of 5 mol% NHC precursors and 1.6 equiv. potassium carbonate, various thiols coupled with α-haloenals to produce α-thioenals in 53% to 91% yield and excellent Z-selectivity.
authors.affiliation: Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Xinjiang Uygur Autonomous Region, 832000, China. helin@shzu.edu.cn db_tea@shzu.edu.cn.
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Hao
authors.initials: H
authors.lastname: Guo
authors.forename: Yuan-Zhen
authors.initials: YZ
authors.lastname: Li
authors.forename: Guang-Fen
authors.initials: GF
authors.lastname: Du
authors.forename: Bin
authors.initials: B
authors.lastname: Dai
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry
chemical_list: D006571:Heterocyclic Compounds; D013438:Sulfhydryl Compounds; C030011:carbene; D013455:Sulfur; D002244:Carbon; D008697:Methane