title: Multiplexed immunoglobulin E sensitization in relation to exhaled nitric oxide in a population sample of children.
abstract: This study investigated the relationship between the specific immunoglobulin E (IgE) profile for 40 allergens using a novel microarray technique (BioIC) and fraction of exhaled nitric oxide (FeNO) in a population sample of 1321 children. Significant positive associations were found between FeNO and sensitization to mites (P < 0.001), animals (P = 0.001), cockroaches (P < 0.001), and foods (P = 0.042), and furthermore, between FeNO and the number of sensitizations (all P < 0.05) or the sum of specific IgE (all P ≤ 0.01) against the aforementioned allergen categories. Specifically, sensitization to the following allergens was significantly related to higher FeNO: Dermatophagoides pteronyssinus, Dermatophagoides farina, Blomia tropicalis, cat, German cockroach, Oriental cockroach, codfish, crab, shrimp, and cheese (all P ≤ 0.01). In conclusion, IgE sensitization to mites, pets, cockroaches, seafood, and cheese, respectively, is significantly associated with elevated FeNO levels in a dose-dependent fashion in children. Our results provide new evidence that sensitization to certain food allergens may contribute to prompt inflammation in the airways.
authors.affiliation: Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan.
authors.forename: T-C
authors.initials: TC
authors.lastname: Yao
authors.forename: H-J
authors.initials: HJ
authors.lastname: Tsai
authors.forename: Y-L
authors.initials: YL
authors.lastname: Tu
authors.forename: S-W
authors.initials: SW
authors.lastname: Chang
authors.forename: M-C
authors.initials: MC
authors.lastname: Hua
authors.forename: S-L
authors.initials: SL
authors.lastname: Liao
authors.forename: M-H
authors.initials: MH
authors.lastname: Tsai
authors.forename: C-Y
authors.initials: CY
authors.lastname: Chiu
authors.forename: S-H
authors.initials: SH
authors.lastname: Lai
authors.forename: K-W
authors.initials: KW
authors.lastname: Yeh
authors.forename: J-L
authors.initials: JL
authors.lastname: Huang
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000145:classification / Q000276:immunology; D000818:Animals; D002648:Child; D045853:Exhalation; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology / Q000276:immunology / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D011446:Prospective Studies
chemical_list: D000485:Allergens; D009569:Nitric Oxide; D007073:Immunoglobulin E
keywords: Asian; allergic sensitization; atopy; children; exhaled nitric oxide