title: Applications of chitosan nanoparticles in drug delivery.
abstract: We have reviewed the binding affinities of several antitumor drugs doxorubicin (Dox), N-(trifluoroacetyl) doxorubicin (FDox), tamoxifen (Tam), 4-hydroxytamoxifen (4-Hydroxytam), and endoxifen (Endox) with chitosan nanoparticles of different sizes (chitosan-15, chitosan-100, and chitosan-200 KD) in order to evaluate the efficacy of chitosan nanocarriers in drug delivery systems. Spectroscopic and molecular modeling studies showed the binding sites and the stability of drug-polymer complexes. Drug-chitosan complexation occurred via hydrophobic and hydrophilic contacts as well as H-bonding network. Chitosan-100 KD was the more effective drug carrier than the chitosan-15 and chitosan-200 KD.
authors.affiliation: Department of Chemistry-Physics, University of Québec at Trois-Rivières, Trois-Rivières, QC, Canada.
authors.forename: H A
authors.initials: HA
authors.lastname: Tajmir-Riahi
authors.forename: Sh
authors.initials: Sh
authors.lastname: Nafisi
authors.forename: S
authors.initials: S
authors.lastname: Sanyakamdhorn
authors.forename: D
authors.initials: D
authors.lastname: Agudelo
authors.forename: P
authors.initials: P
authors.lastname: Chanphai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001665:Binding Sites; D048271:Chitosan / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry; D004337:Drug Carriers; D006860:Hydrogen Bonding; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D013629:Tamoxifen / Q000031:analogs & derivatives / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D013629:Tamoxifen; C016601:afimoxifene; C055492:4-hydroxy-N-desmethyltamoxifen; D004317:Doxorubicin; D048271:Chitosan