title: Perioperative levels and changes of high-sensitivity troponin T are associated with cardiovascular events in vascular surgery patients.
abstract: OBJECTIVE
  Myocardial infarction after major surgery is frequent, drives outcome, and consumes health resources. Specific prediction and detection of perioperative myocardial infarction is an unmet clinical need. With the widespread use of high-sensitive cardiac troponin T assays, positive tests become frequent, but their diagnostic or prognostic impact is arguable. We, therefore, studied the association of routinely determined pre- and postoperative high-sensitive cardiac troponin T with the occurrence of major adverse cardiac events.
  
  
  METHODS
  This study was a prospective non-interventional trial.
  
  
  METHODS
  This study was conducted at Hannover Medical School in Germany.
  
  
  METHODS
  A total of 455 patients undergoing open vascular surgery were followed for 30 days for the occurrence of major adverse cardiac events.
  
  
  METHODS
  None.
  
  
  RESULTS
  Preoperative and 24-hour postoperative high-sensitive cardiac troponin T measurements and the respective changes were correlated to medical history and the occurrence of major adverse cardiac events (cardiovascular death, myocardial infarction, and ischemia). Pre- and postoperative high-sensitive cardiac troponin T measurements demonstrated a majority of patients with detectable troponin levels preoperatively and an increase over the 24 hours after surgery. The level of high-sensitive cardiac troponin T was significantly associated with preexisting diseases that constitute the Lee's Revised Cardiac Risk Index. A preoperative high-sensitive cardiac troponin T greater than or equal to 17.8 ng/L and a perioperative high-sensitive cardiac troponin T change greater than or equal to 6.3 ng/L are independently associated with the occurrence of major adverse cardiac events. Adding high-sensitive cardiac troponin T absolute change to the Revised Cardiac Risk Index improves the risk predictive accuracy of the score as evidenced by increased area under receiver operating characteristic and significant reclassification effects.
  
  
  CONCLUSIONS
  The risk predictive power of high-sensitive cardiac troponin T change in addition to the Revised Cardiac Risk Index could facilitate 1) detection of patients at highest risk for perioperative myocardial ischemia, 2) evaluation and development of cardioprotective therapeutic strategies, and 3) decisions for admission to and discharge from high-density care units.
authors.affiliation: 1Department of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany. 2Institute of Biostatistics, Hannover Medical School, Hannover, Germany. 3Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany. 4Department of Clinical Chemistry, Hannover Medical School, Hannover, Germany.
authors.forename: Hans-Jörg
authors.initials: HJ
authors.lastname: Gillmann
authors.forename: Antje
authors.initials: A
authors.lastname: Meinders
authors.forename: Anika
authors.initials: A
authors.lastname: Grohennig
authors.forename: Jan
authors.initials: J
authors.lastname: Larmann
authors.forename: Christoph
authors.initials: C
authors.lastname: Bünte
authors.forename: Simone
authors.initials: S
authors.lastname: Calmer
authors.forename: Bianca
authors.initials: B
authors.lastname: Sahlmann
authors.forename: Saad
authors.initials: S
authors.lastname: Rustum
authors.forename: Thomas
authors.initials: T
authors.lastname: Aper
authors.forename: Ralf
authors.initials: R
authors.lastname: Lichtinghagen
authors.forename: Armin
authors.initials: A
authors.lastname: Koch
authors.forename: Omke E
authors.initials: OE
authors.lastname: Teebken
authors.forename: Gregor
authors.initials: G
authors.lastname: Theilmeier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology*; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000209:etiology*; D059035:Perioperative Period; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D012044:Regression Analysis; D018570:Risk Assessment; D020107:Troponin T / Q000097:blood*; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
chemical_list: D020107:Troponin T