title: A retrospective cohort study to evaluate the impact of meaningful weight loss on fertility outcomes in an overweight population with infertility.
abstract: OBJECTIVE
  To determine if meaningful weight loss (≥10%) improved conception and live birth rates of overweight patients with infertility.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Overweight patients (body mass index ≥25 kg/m(2); n = 52) being treated for infertility and referred for weight loss counseling.
  
  
  METHODS
  Patients were given a "meaningful" weight loss goal of 10%. They were followed by an endocrinologist who provided diet and exercise recommendations, metabolic screening, and pharmacologic intervention when indicated.
  
  
  METHODS
  Pregnancy rate, live birth rate, weight loss.
  
  
  RESULTS
  Thirty-two percent of the patients achieved meaningful weight loss. Patients achieving meaningful weight loss had significantly higher conception (88% vs. 54%) and live birth rates (71% vs. 37%) than those who did not.
  
  
  CONCLUSIONS
  Weight loss improves live birth rates in overweight patients with infertility. Health care providers should incorporate weight loss counseling when caring for overweight patients who plan to conceive.
authors.affiliation: Department of Obstetrics and Gynecology, Stanford University Hospital, Stanford, California. Electronic address: jkort@stanford.edu.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Kort
authors.affiliation: Stanford University School of Medicine, Stanford, California.
authors.forename: Caitlin
authors.initials: C
authors.lastname: Winget
authors.affiliation: Division of Endocrinology, Department of Medicine, Stanford University Hospital, Stanford, California.
authors.forename: Sun H
authors.initials: SH
authors.lastname: Kim
authors.affiliation: Department of Reproductive Endocrinology and Infertility, Stanford University Hospital, Stanford, California.
authors.forename: Ruth B
authors.initials: RB
authors.lastname: Lathi
mesh_terms: D000328:Adult; D001835:Body Weight / Q000502:physiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology* / Q000628:therapy*; D050177:Overweight / Q000453:epidemiology* / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends*; D012189:Retrospective Studies; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*
keywords: BMI; Obesity; infertility; overweight; weight loss