title: The effect of levobupivacaine and bupivacaine on QT, corrected QT (Qtc), and P wave dispersions in cesarean section.
abstract: OBJECTIVE
  In our study we aimed to investigate the effect of bupivacaine and levobupivacaine on QT, corrected QT (QTc), and P wave dispersion durations during spinal anesthesia in cesarean section.
  
  
  METHODS
  Sixty parturients scheduled for elective cesarean section in ASA I-II risk groups were included in the study. Baseline electrocardiographic (ECG) records of the patients were obtained in the operation room. Heart rate (HR), non-invasive blood pressure (NIBP), peripheral oxygen saturation (SpO2) and respiration rates (RR) were recorded. Venous cannulation was performed with 18G cannula and fluid preload made with 10 mL.kg(-1). Lactated Ringer solution. After fluid preload, second ECG recordings were taken and the patients were randomly separated into two groups. Group B (n = 30) received 10mg of bupivacaine and Group L (n = 30) received 10mg of levobupivacaine for spinal anesthesia. ECG recordings were repeated at 1, 5 and 10 minutes after spinal block. HR, NIBP, SpO2, RR and sensory block levels were also recorded at the same time intervals. At predetermined time intervals of spinal anesthesia, P wave dispersion (Pwd), QT dispersion (QTd), and QTc dispersion (QTcd) durations were measured from ECG records. QT and QTc durations are calculated with Bazzett formula.
  
  
  RESULTS
  There was no difference between two groups according to block levels, hemodynamic parameters, Pwd, QTd, QTc and QTcd durations.
  
  
  CONCLUSIONS
  Bupivacaine and levobupivacaine may be preferred in spinal anesthesia in pregnant patients who have extended Pwd and QTcd preoperatively.
authors.affiliation: Staff Doctor, MD, Karaelmas University, School of Medicine, Department of Anaesthesiology and Reanimation, Zonguldak, Turkey.
authors.forename: Yeliz
authors.initials: Y
authors.lastname: Deniz
authors.affiliation: Associate Professor, MD, Dokuz Eylül University, School of Medicine, Department of Anaesthesiology and Reanimation, İzmir, Turkey (Formerly Karaelmas University, Zonguldak, Turkey).
authors.forename: Dilek
authors.initials: D
authors.lastname: Okyay
authors.affiliation: Associate Professor, MD, Dokuz Eylül University, School of Medicine, Department of Anaesthesiology and Reanimation, İzmir, Turkey (Formerly Karaelmas University, School of Medicine, Department of Anaesthesiology and Reanimation, Zonguldak, Turkey). Electronic address: vhanci@gmail.com.
authors.forename: Volkan
authors.initials: V
authors.lastname: Hanci
authors.affiliation: Associate Professor, MD, Dokuz Eylül University, School of Medicine, Department of Anaesthesiology and Reanimation, İzmir, Turkey (Formerly Karaelmas University, Zonguldak, Turkey).
authors.forename: Serhan
authors.initials: S
authors.lastname: Yurtlu
authors.affiliation: Associate Professor, MD, Karaelmas University, School of Medicine, Department of Anaesthesiology and Reanimation, Zonguldak, Turkey.
authors.forename: Hilal
authors.initials: H
authors.lastname: Ayoğlu
authors.affiliation: Professor, MD, Karaelmas University, School of Medicine, Department of Anaesthesiology and Reanimation, Zonguldak, Turkey.
authors.forename: Işil Özkoçak
authors.initials: IÖ
authors.lastname: Turan
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal; D000779:Anesthetics, Local / Q000494:pharmacology*; D002045:Bupivacaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002585:Cesarean Section; D004562:Electrocardiography / Q000187:drug effects*; D005260:Female; D006801:Humans; D000077554:Levobupivacaine; D008875:Middle Aged; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; D000077554:Levobupivacaine; D002045:Bupivacaine
keywords: Anesthesia; Bupivacaine/levobupivacaine; Cesarean Section; Electrocardiography; Spinal