title: Characterization of azithromycin-resistant Neisseria gonorrhoeae isolated in Tokyo in 2005-2011.
abstract: A total of 122 Neisseria gonorrhoeae isolated in the Tokyo metropolitan area in 2005-2011 were collected and analyzed by N. gonorrhoeae multiantigen sequence typing (NG-MAST) and for their susceptibility to azithromycin and ceftriaxone. All 122 strains were susceptible to ceftriaxone, but 8 strains were azithromycin-resistant, defined as an azithromycin MIC ≥ 1 μg/ml. The 8 azithromycin-resistant strains were in 6 NG-MAST types, 3 strains in NG-MAST type 1407 and each of the other 5 strains in a different NG-MAST type. NG-MAST type 1407 strains are multidrug-resistant and are disseminated worldwide.
authors.affiliation: Byotai-Seiri Laboratory, Japan.
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Takayama
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, Japan. Electronic address: shuichin@nih.go.jp.
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Nakayama
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Shimuta
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Morita-Ishihara
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohnishi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin
keywords: Azithromycin; Drug resistance; Neisseria gonorrhoeae; Surveillance; Treatment guidelines