title: Successful neoadjuvant chemotherapy for large cell neuroendocrine carcinoma of the cervix: A case report.
abstract: •We present a case of cervical large cell neuroendocrine carcinoma (LCNEC) and neoadjuvant chemotherapy with irinotecan plus cisplatin that was extremely effective.•Cervical LCNEC is uncommon and highly aggressive, and optimal therapy has yet to be determined.•This case suggests that neoadjuvant chemotherapy followed by radical hysterectomy could be a useful treatment option for bulky cervical LCNEC.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Omori
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hashi
authors.affiliation: Department of Pathology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Tagaya
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
authors.forename: Shuji
authors.initials: S
authors.lastname: Hirata
keywords: Bulky cervical cancer; Neoadjuvant chemotherapy; Neuroendocrine carcinoma; Radical hysterectomy; Uterine cervix