title: Testicular "hyperstimulation" syndrome: a case of functional gonadotropinoma.
abstract: Gonadotropins secreting pituitary tumors tend to present as sellar mass with hypogonadism. Biologically active LH secretion by these tumors resulting in elevated testosterone is extremely rare. We report a case of a 48-year-old male patient who presented with giant pituitary tumor, elevated testosterone, and elevated levels of gonadotropins. Surgical resection of the tumor resulted in normalization of gonadotropins and fall in serum testosterone to subnormal levels in the postoperative period confirming that the tumor was secreting bioactive luteinizing hormone (LH).
authors.affiliation: Topiwala National Medical College and BYL Nair Charitable Hospital, Mumbai 400008, India.
authors.forename: Astha
authors.initials: A
authors.lastname: Thakkar
authors.affiliation: Endocrinology, Diabetes & Metabolism Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Subramanian
authors.initials: S
authors.lastname: Kannan
authors.affiliation: Endocrinology, Diabetes & Metabolism Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Hamrahian
authors.affiliation: Institute of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Prayson
authors.affiliation: Brain Tumor & Neuro-Oncology Center, Department of Neurosurgery, The Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Weil
authors.affiliation: Endocrinology, Diabetes & Metabolism Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Faiman