title: COMPARTMENTS: unification and visualization of protein subcellular localization evidence.
abstract: Information on protein subcellular localization is important to understand the cellular functions of proteins. Currently, such information is manually curated from the literature, obtained from high-throughput microscopy-based screens and predicted from primary sequence. To get a comprehensive view of the localization of a protein, it is thus necessary to consult multiple databases and prediction tools. To address this, we present the COMPARTMENTS resource, which integrates all sources listed above as well as the results of automatic text mining. The resource is automatically kept up to date with source databases, and all localization evidence is mapped onto common protein identifiers and Gene Ontology terms. We further assign confidence scores to the localization evidence to facilitate comparison of different types and sources of evidence. To further improve the comparability, we assign confidence scores based on the type and source of the localization evidence. Finally, we visualize the unified localization evidence for a protein on a schematic cell to provide a simple overview. Database URL: http://compartments.jensenlab.org.
authors.affiliation: Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), 69117 Heidelberg, Germany, Bioinformatics Core Facility, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, 4362 Esch-sur-Alzette, Luxembourg, Department of Disease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark, CSIRO Computational Informatics, Sydney, NSW 2113 Australia and Garvan Institute of Medical Research, Sydney, NSW 2100, Australia.
authors.forename: Janos X
authors.initials: JX
authors.lastname: Binder
authors.forename: Sune
authors.initials: S
authors.lastname: Pletscher-Frankild
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Tsafou
authors.forename: Christian
authors.initials: C
authors.lastname: Stolte
authors.forename: Seán I
authors.initials: SI
authors.lastname: O'Donoghue
authors.forename: Reinhard
authors.initials: R
authors.lastname: Schneider
authors.forename: Lars Juhl
authors.initials: LJ
authors.lastname: Jensen
mesh_terms: D002451:Cell Compartmentation; D057225:Data Mining; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D011506:Proteins / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism
chemical_list: D011506:Proteins