title: A new cyclopeptide with antifungal activity from the co-culture broth of two marine mangrove fungi.
abstract: A new cyclic tetrapeptide, cyclo-(L-leucyl-trans-4-hydroxy-L-prolyl-D-leucyl-trans-4-hydroxy-L-proline) (1), was isolated from the co-culture broth of two mangrove fungi Phomopsis sp. K38 and Alternaria sp. E33. The structure of 1 was determined by analysis of spectroscopic data and Marfey's analytic method. Primary bioassay demonstrated that compound 1 exhibited moderate to high inhibitory activity against four crop-threatening fungi including Gaeumannomyces graminis, Rhizoctonia cerealis, Helminthosporium sativum and Fusarium graminearum as compared with triadimefon.
authors.affiliation: a College of Science, Institute of Biomaterial, South China Agricultural University, Guangzhou , 510642 Guangdong , P.R. China.
authors.forename: Chunyuan
authors.initials: C
authors.lastname: Li
authors.forename: Jinhua
authors.initials: J
authors.lastname: Wang
authors.forename: Cuiping
authors.initials: C
authors.lastname: Luo
authors.forename: Weijia
authors.initials: W
authors.lastname: Ding
authors.forename: Daniel G
authors.initials: DG
authors.lastname: Cox
mesh_terms: D000528:Alternaria / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D018920:Coculture Techniques; D005670:Fusarium / Q000187:drug effects; D006375:Helminthosporium / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012232:Rhizoctonia / Q000187:drug effects; D043982:Rhizophoraceae / Q000382:microbiology; D014230:Triazoles / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D010456:Peptides, Cyclic; D014230:Triazoles; C000591762:cyclo-(L-leucyl-trans-4-hydroxy-L-prolyl-D-leucyl-trans-4-hydroxy-L-proline); C032910:triadimefon
keywords: antifungal activity; co-culture; cyclopeptide; mangrove fungi