title: Myasthenic crisis after a renal transplant successfully treated with intravenous immunoglobulin.
abstract: Myasthenia gravis is an autoimmune disease characterized by muscle weakness. Myasthenic crisis is a life-threatening complication of myasthenia gravis precipitated by several factors. We experienced a myasthenic crisis after a deceased-donor kidney transplant in a 35-year-old woman who already had been diagnosed with myasthenia gravis. She received mechanical ventilatory support and intravenous immunoglobulin for treatment of the myasthenic crisis. During the early posttransplant period, she recovered with immediate graft function, and her graft functioning did not deteriorate during the myasthenic crisis. We suggest that physicians be aware of worsening of myasthenia gravis when patients with myasthenia gravis undergo a kidney transplant.
authors.affiliation: From the Department of 1Internal Medicine,Pusan National University School of Medicine,Yangsan and the Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.
authors.forename: In Hye
authors.initials: IH
authors.lastname: Hwang
authors.forename: Kyung Nam
authors.initials: KN
authors.lastname: Lee
authors.forename: Il Young
authors.initials: IY
authors.lastname: Kim
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Lee
authors.forename: Soo Bong
authors.initials: SB
authors.lastname: Lee
authors.forename: Dae Seong
authors.initials: DS
authors.lastname: Kim
authors.forename: Sang Heon
authors.initials: SH
authors.lastname: Song
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Seong
authors.forename: Ihm Soo
authors.initials: IS
authors.lastname: Kwak
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000328:Adult; D018450:Disease Progression; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D009157:Myasthenia Gravis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012121:Respiration, Artificial; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents