title: Association of reticular pseudodrusen and early onset drusen.
abstract: Purpose. To report an association between reticular pseudodrusen, located above the retinal pigment epithelium (RPE), and Early Onset Drusen (EOD) as described using Spectral-Domain Optical Coherence Tomography (SD-OCT). Methods. Eight patients (16 eyes) with EOD were examined. EOD were classified into three entities called Large Colloid Drusen (LCD), Malattia Leventinese (ML), and Cuticular Drusen (CD). Best-corrected visual acuity, fundus examination, color fundus photographs, fundus autofluorescence (FAF), fluorescein angiography (FA), indocyanine green angiography (ICGA), and SD-OCT were performed in all study patients. Results. Four patients had LCD, 2 had ML, and 2 had CD. Reticular pseudodrusen were observed with SD-OCT in all study patients; all these patients had hyperreflective lesions above and below the RPE. Conclusion. Early Onset Drusen appear to be associated with reticular pseudodrusen. SD-OCT is helpful in distinguishing the location of the deposits that are above and below the RPE in EOD. Further studies are needed to understand the role of reticular pseudodrusen in the pathophysiology of EOD.
authors.affiliation: Department of Ophthalmology, Croix-Rousse University Hospital, 103 Grande rue de la Croix Rousse, 69317 Lyon Cedex 04, France.
authors.forename: Flore
authors.initials: F
authors.lastname: De Bats
authors.affiliation: Professor Sahel Department, Rothschild Ophthalmologic Foundation, 25 rue Manin, 75019 Paris, France ; Kleber Retinal Center, 50 Cours Franklin Roosevelt, 69006 Lyon, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Wolff
authors.affiliation: Professor Sahel Department, Rothschild Ophthalmologic Foundation, 25 rue Manin, 75019 Paris, France.
authors.forename: Martine
authors.initials: M
authors.lastname: Mauget-Faÿsse
authors.affiliation: Department of Ophthalmology, Gui de Chauliac University Hospital, 80 Avenue Augustin Fliche, 34295 Montpellier Cedex 5, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Meunier
authors.affiliation: Department of Ophthalmology, Croix-Rousse University Hospital, 103 Grande rue de la Croix Rousse, 69317 Lyon Cedex 04, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Denis
authors.affiliation: Department of Ophthalmology, Croix-Rousse University Hospital, 103 Grande rue de la Croix Rousse, 69317 Lyon Cedex 04, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Kodjikian