title: miR-137: a new player in schizophrenia.
abstract: Schizophrenia is a complex genetic disease and characterized by affective, cognitive, neuromorphological, and molecular abnormalities that may have a neurodevelopmental origin. MicroRNAs (miRNAs) are critical to neurodevelopment and adult neuronal processes by modulating the activity of multiple genes within biological networks. MiR-137 as a brain-enriched microRNA, plays important roles in regulating embryonic neural stem cells (NSCs) fate determination, neuronal proliferation and differentiation, and synaptic maturation. Its dysregulation causes changes in the gene expression regulation network of the nervous system, thus inducing mental disorders. Recently, miR-137 has been confirmed as a gene related to schizophrenia susceptibility. In the following review, we summarize the expression pattern, epigenetic regulation and functions of miR-137. A more complete picture of the miR-137, which is dysregulated in psychiatric illness, may improve our understanding of the molecular mechanisms underlying schizophrenia.
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China. amysays@live.com.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Yin
authors.affiliation: Department of Psychiatry, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China. linjuda@126.com.
authors.forename: Juda
authors.initials: J
authors.lastname: Lin
authors.affiliation: Department of Psychiatry, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China. lxd708@163.com.
authors.forename: Xudong
authors.initials: X
authors.lastname: Luo
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China. xiaohonghuacyy@163.com.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Chen
authors.affiliation: Unit on Synapse Development and Plasticity, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. lizheng2@mail.nih.gov.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China. sihan1107@126.com.
authors.forename: Guoda
authors.initials: G
authors.lastname: Ma
authors.affiliation: Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China. likeshen1971@126.com.
authors.forename: Keshen
authors.initials: K
authors.lastname: Li
mesh_terms: D002454:Cell Differentiation; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D058953:Neural Stem Cells / Q000166:cytology; D055495:Neurogenesis; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction
chemical_list: C545567:MIRN137 microRNA, human; D035683:MicroRNAs