title: Is there a competition for oxygen availability between respiratory and limb muscles?
abstract: If a competition between the oxygen demands of limb and respiratory muscles happens, hypoxia may favor redistribution of blood flow from peripheral to respiratory muscles during heavy exercise. This hypothesis was tested in eighteen lowlanders and 27 highlanders at 4350m altitude. During an incremental exercise, the regional tissue oxygen saturation (rSO2) and tissue hemoglobin concentration ([Hbt]) of the intercostal muscles and vastus medialis were monitored simultaneously by NIRS. The intercostal and vastus medialis rSO2 values were lower at altitude than at sea level (-10%, p<0.001) and decreased similarly during incremental exercise (p<0.001) while [Hbt] values increased. At maximal exercise, the intercostal rSO2 was lower than the vastus medialis rSO2 in lowlanders (-7%, p<0.001). In highlanders the time patterns were similar but intercostal rSO2 was less decreased at exercise (p<0.05). Maximal exercise performed in hypoxia did not alter the kinetics of rSO2 and [Hbt] in peripheral muscles. These findings do not favor the hypothesis of blood flow redistribution.
authors.affiliation: Laboratory «MOVE» Poitiers University, UPRES-EA 6314, 8 Allée Jean Monnet, 86000 Poitiers, France. Electronic address: claire.de.bisschop@univ-poitiers.fr.
authors.forename: C
authors.initials: C
authors.lastname: de Bisschop
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, Free University of Brussels, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Beloka
authors.affiliation: Department of Pulmonology, VU University Medical Center, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: Groepenhoff
authors.affiliation: Department of Pulmonology, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
authors.forename: M N
authors.initials: MN
authors.lastname: van der Plas
authors.affiliation: Department of Pulmonology, Medical Center Haaglanden, The Hague, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Overbeek
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, Free University of Brussels, Belgium.
authors.forename: R
authors.initials: R
authors.lastname: Naeije
authors.affiliation: Laboratory of Physiology, Medical Faculty, University of Bordeaux, France.
authors.forename: H
authors.initials: H
authors.lastname: Guenard
mesh_terms: D000328:Adult; D000368:Aged; D000531:Altitude; D000532:Altitude Sickness / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D007366:Intercostal Muscles / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D052097:Quadriceps Muscle / Q000378:metabolism*; D019265:Spectroscopy, Near-Infrared; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D010100:Oxygen
keywords: Altitude; Exercise; Highlanders; Intercostals; Regional tissue oxygen saturation; Vastus medialis