title: Claudin and ovarian cancer.
abstract: Claudins are a family of proteins and the most important component of the tight junction. They constitute a paracellular barrier that controls the flow of molecules in the intercellular space of an epithelium. Although it seems that claudin should be down regulated in cancer cell, some claudins are, in fact highly elevated in various human cancers, including ovarian cancer. Whereas the functional significance of claudin overexpression in ovarian carcinoma is unclear, these proteins are important for migration, invasion, and survival of ovarian cancer cells. They clearly represent a general pathway in tumorigenesis, are a novel marker for ovarian cancer and may become a target for therapy or diagnosis of this disease.
authors.affiliation: Netaji Subhas Chandra Bose Cancer Research Institute,16a Park Lane, Kolkata, India.
authors.forename: Chinmoy K
authors.initials: CK
authors.lastname: Bose
authors.affiliation: Netaji Subhas Chandra Bose Cancer Research Institute,16a Park Lane, Kolkata, India.
authors.forename: Ashis
authors.initials: A
authors.lastname: Mukhopadhyay
keywords: Clostridium perfringens enterotoxin; Tight junction; claudin; occludin; ovarian cancer