title: Fosfomycin susceptibility of canine methicillin-resistant Staphylococcus pseudintermedius isolates.
abstract: The effectiveness of fosfomycin was examined across 31 methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains by agar dilution. Prevalence of the fosfomycin-resistance determinant gene, fosB, was assessed by PCR analysis. Results found that 84% of isolates were fosfomycin-susceptible. Interestingly, 87% of isolates possessed fosB, indicating no association between this putative staphylococci resistance gene and phenotypic resistance. Further evaluation of fosfomycin as a potential treatment of MRSP in dogs is warranted.
authors.affiliation: BioNano Laboratory, School of Engineering, University of Guelph, Guelph N1G 2W1, Canada.
authors.forename: Matthew
authors.initials: M
authors.lastname: DiCicco
authors.affiliation: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph N1G 2W1, Canada.
authors.forename: Scott
authors.initials: S
authors.lastname: Weese
authors.affiliation: BioNano Laboratory, School of Engineering, University of Guelph, Guelph N1G 2W1, Canada. Electronic address: sneethir@uoguelph.ca.
authors.forename: Suresh
authors.initials: S
authors.lastname: Neethirajan
authors.affiliation: Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph N1G 2W1, Canada.
authors.forename: Joyce
authors.initials: J
authors.lastname: Rousseau
authors.affiliation: Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph N1G 2W1, Canada.
authors.forename: Ameet
authors.initials: A
authors.lastname: Singh
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002170:Canada; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D004285:Dogs; D005578:Fosfomycin / Q000494:pharmacology* / Q000627:therapeutic use; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015995:Prevalence; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D013210:Staphylococcus / Q000254:growth & development*; D014481:United States
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D016760:Proto-Oncogene Proteins c-fos; D005578:Fosfomycin
keywords: Fosfomycin; MRSP; Methicillin-resistant; Staphylococcus pseudintermedius; fosB