title: Results of surgical treatment for non-small cell lung cancer with positive sputum cytology: experience from a single institution.
abstract: BACKGROUND
  Little is known about the prognostic value of positive sputum cytology in patients with non-small cell lung cancer (NSCLC).
  
  
  METHODS
  We retrospectively examined the clinicopathological data of 30 patients who had undergone complete resection for NSCLC with positive sputum cytology between September 2002 and June 2011.
  
  
  RESULTS
  Distant recurrence occurred significantly more frequently in the patients with adenocarcinoma (Ad) than in those with squamous cell carcinoma (p = 0.01). The most frequent metastatic site after surgery was the brain, occurring in five patients with Ad. The 5-year disease-free survival (DFS) and overall survival (OS) rates of the 30 patients were 53 and 49%, respectively. In multivariate analyses, radiographic feature of pneumonic-type shadow and pathological N (pN) 1-2 status were the independent factors significantly correlated with poor DFS (p = 0.009, 0.001, respectively), whereas pN 1-2 status was the only independent factor significantly correlated with poor OS (p = 0.009).
  
  
  CONCLUSIONS
  Surgical outcome for NSCLC with positive sputum cytology was unfavorable at our institution. Close surveillance after a curative resection is mandatory for those patients presenting with radiographic feature of pneumonic-type shadow as those with lymph node metastases because they are at high risk for recurrence.
authors.affiliation: Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kozu
authors.affiliation: Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Maniwa
authors.affiliation: Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Takahashi
authors.affiliation: Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Isaka
authors.affiliation: Department of General Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Ohde
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology; D009367:Neoplasm Staging; D011013:Pneumonectomy; D011379:Prognosis; D012189:Retrospective Studies; D013183:Sputum / Q000166:cytology*; D015996:Survival Rate / Q000639:trends; D016896:Treatment Outcome