title: Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru.
abstract: We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDR-TB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.
authors.affiliation: Laboratorio de Biotecnología y Biología Molecular, Instituto Nacional de Salud, Lima, Peru.
authors.forename: M
authors.initials: M
authors.lastname: Galarza
authors.forename: D
authors.initials: D
authors.lastname: Tarazona
authors.forename: V
authors.initials: V
authors.lastname: Borda
authors.forename: J C
authors.initials: JC
authors.lastname: Agapito
authors.forename: H
authors.initials: H
authors.lastname: Guio