title: Postnatal inflammation in the pathogenesis of bronchopulmonary dysplasia.
abstract: Exposure to hyperoxia, invasive mechanical ventilation, and systemic/local sepsis are important antecedents of postnatal inflammation in the pathogenesis of bronchopulmonary dysplasia (BPD). This review will summarize information obtained from animal (baboon, lamb/sheep, rat and mouse) models that pertain to the specific inflammatory agents and signaling molecules that predispose a premature infant to BPD.
authors.affiliation: Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut.
authors.forename: Vineet
authors.initials: V
authors.lastname: Bhandari
mesh_terms: D000818:Animals; D001997:Bronchopulmonary Dysplasia / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D018496:Hyperoxia / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D007231:Infant, Newborn; D007234:Infant, Premature; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D010215:Papio; D051381:Rats; D018805:Sepsis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012756:Sheep
keywords: hyperoxia; infection; invasive ventilation; lung; newborn