title: Recruiting cytotoxic T cells to folate-receptor-positive cancer cells.
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Sumith A
authors.initials: SA
authors.lastname: Kularatne
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Vishal
authors.initials: V
authors.lastname: Deshmukh
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Marco
authors.initials: M
authors.lastname: Gymnopoulos
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Biroc
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Jinming
authors.initials: J
authors.lastname: Xia
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Shaila
authors.initials: S
authors.lastname: Srinagesh
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Ying
authors.initials: Y
authors.lastname: Sun
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Ning
authors.initials: N
authors.lastname: Zou
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Mark
authors.initials: M
authors.lastname: Shimazu
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Jason
authors.initials: J
authors.lastname: Pinkstaff
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Semsi
authors.initials: S
authors.lastname: Ensari
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Nick
authors.initials: N
authors.lastname: Knudsen
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Anthony
authors.initials: A
authors.lastname: Manibusan
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Axup
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Chanhyuk
authors.initials: C
authors.lastname: Kim
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Vaughn
authors.initials: V
authors.lastname: Smider
authors.affiliation: Ambrx Inc., North Torrey Pines Road, La Jolla, CA 92037.
authors.forename: Tsotne
authors.initials: T
authors.lastname: Javahishvili
authors.affiliation: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Schultz
mesh_terms: D000818:Animals; D017252:CD3 Complex / Q000276:immunology; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D058973:Folate Receptors, GPI-Anchored / Q000378:metabolism*; D005492:Folic Acid / Q000737:chemistry; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000737:chemistry / Q000276:immunology; D007141:Immunoglobulin Fc Fragments / Q000737:chemistry / Q000276:immunology; D007074:Immunoglobulin G / Q000737:chemistry / Q000276:immunology; D007167:Immunotherapy; D007963:Leukocytes, Mononuclear / Q000166:cytology; D008297:Male; D051379:Mice; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology*
chemical_list: D017252:CD3 Complex; D058973:Folate Receptors, GPI-Anchored; D007140:Immunoglobulin Fab Fragments; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; C041323:immunoglobulin Facb fragment; D005492:Folic Acid
keywords: T cells; bispecific antibody; cancer; folate receptor; immunotherapy