title: First report of KPC-2 Carbapenemase-producing Klebsiella pneumoniae in Japan.
abstract: We investigated a novel Japanese isolate of sequence type 11 (ST11), the Klebsiella pneumoniae carbapenemase-2 (KPC-2)-producing K. pneumoniae strain Kp3018, which was previously obtained from a patient treated at a Brazilian hospital. This strain was resistant to various antibiotic classes, including carbapenems, and harbored the gene blaKPC-2, which was present on the transferable plasmid of ca. 190 kb, in addition to the blaCTX-M-15 gene. Furthermore, the ca. 2.3-kb sequences (ISKpn8-blaKPC-2-ISKpn6-like), encompassing blaKPC-2, were found to be similar to those of K. pneumoniae strains from China.
authors.affiliation: Department of Microbiology and Immunology, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Saito
authors.forename: Rieko
authors.initials: R
authors.lastname: Takahashi
authors.forename: Etsuko
authors.initials: E
authors.lastname: Sawabe
authors.forename: Saho
authors.initials: S
authors.lastname: Koyano
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Mari
authors.initials: M
authors.lastname: Shima
authors.forename: Hiroto
authors.initials: H
authors.lastname: Ushizawa
authors.forename: Toshihide
authors.initials: T
authors.lastname: Fujie
authors.forename: Naoki
authors.initials: N
authors.lastname: Tosaka
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kato
authors.forename: Kyoji
authors.initials: K
authors.lastname: Moriya
authors.forename: Shuji
authors.initials: S
authors.lastname: Tohda
authors.forename: Naoko
authors.initials: N
authors.lastname: Tojo
authors.forename: Ryuji
authors.initials: R
authors.lastname: Koike
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kubota
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D001938:Brazil; D015780:Carbapenems / Q000494:pharmacology; D002681:China; D018432:Drug Resistance, Multiple / Q000235:genetics; D007564:Japan; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D001618:beta-Lactamases; C063912:carbapenemase