title: Outcomes and management of viral hepatitis and human immunodeficiency virus co-infection in liver transplantation.
abstract: Liver transplantation for human immunodeficiency virus (HIV) positive patients with viral hepatitis co-infection is increasingly offered in many North American and European liver transplant centers. Prior studies have demonstrated acceptable post-transplant outcomes and no increased risk of HIV complications in patients co-infected with hepatitis B virus (HBV). However, liver transplantation in HIV positive patients with hepatitis C virus (HCV) has poorer outcomes overall, requiring careful selection of candidates. This review aims to summarize the published literature on outcomes after transplant in HIV patients with HBV or HCV related end-stage liver disease and recommendations for management. In particular the pre-transplant factors impacting outcomes in HCV/HIV co-infected candidates and importance of multidisciplinary management will be discussed.
authors.affiliation: Stephen E Congly, Carla S Coffin, Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, AB T2N 4Z6, Canada.
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Congly
authors.affiliation: Stephen E Congly, Carla S Coffin, Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, AB T2N 4Z6, Canada.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Doucette
authors.affiliation: Stephen E Congly, Carla S Coffin, Liver Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, AB T2N 4Z6, Canada.
authors.forename: Carla S
authors.initials: CS
authors.lastname: Coffin
mesh_terms: D060085:Coinfection; D058625:End Stage Liver Disease / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery* / Q000821:virology; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000628:therapy; D006509:Hepatitis B / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D006526:Hepatitis C / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects; D018579:Patient Selection; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
keywords: Co-infection; Hepatitis B virus; Hepatitis C virus; Human immunodeficiency virus co-infection; Liver transplantation