title: Crystal structure, Hirshfeld surfaces and DNA cleavage investigation of two copper(II) complexes containing polypyridine and salicylide ligands.
abstract: Two copper complexes 1 [Cu2(phen)2(salicylaldehyde)2(ClO4)2] and 2 [Cu2 (2,2'-dipyridyl)2(salicylaldehyde)2(ClO4)2] have been synthesized and characterized by elemental analysis and single-crystal X-ray diffraction. These two complexes were display binuclear structure with Cu(II) ions in distorted octahedral environment but antipodal orientation of the binuclear units between them. Molecular Hirshfeld surfaces revealed that the crystal structures of 1 and 2 were supported mainly by H-H, C-H⋯π, π⋯π (C-C), and C-H⋯O intermolecular interactions. DNA cleavage experiments of complexes 1 and 2 revealed that these complexes can intercalation with DNA.
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
authors.forename: Yang-Hui
authors.initials: YH
authors.lastname: Luo
authors.affiliation: School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China. Electronic address: chmsunbw@seu.edu.cn.
authors.forename: Bai-Wang
authors.initials: BW
authors.lastname: Sun
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry; D053837:DNA Cleavage / Q000187:drug effects*; D007364:Intercalating Agents / Q000737:chemistry* / Q000494:pharmacology; D008024:Ligands; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology; D012459:Salicylates / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D056831:Coordination Complexes; D007364:Intercalating Agents; D008024:Ligands; D009942:Organometallic Compounds; D012459:Salicylates; C025564:copper salicylate complex; D015082:2,2'-Dipyridyl; D003300:Copper; D004247:DNA; C427203:calf thymus DNA
keywords: Copper complex; Crystal structure; DNA cleavage; Hirshfeld surfaces