title: Putative biomarkers and therapeutic targets associated with radiation resistance.
abstract: Radiation therapy plays an important role in the management of malignant tumors, however, the problem of radiation resistance resulting in tumor recurrences after treatment is still unsolved. The emergence of novel biomarkers to predict cancer cell insensitivity to ionizing radiation could help to improve therapy results in cancer patients receiving radiation therapy. The proteomic approach could be effectively used to identify proteins associated with cancer radiation resistance. It is generally believed that radiation resistance could be associated with cancer stem cell persistence within the tumor. Therefore, determination of the molecular characteristics of cancer stem cells could provide additional possibilities to discover novel biomarkers to predict radiation resistance in cancer patients. This review addresses proteome-based findings that could be used for further biomarker identification and preclinical and clinical validation.
authors.affiliation: Department of Therapeutic Radiology and Oncology, Innsbruck Medical University, Laboratory for Experimental and Translational Research on Radiation Oncology (EXTRO-Lab), Innsbruck, Austria.
authors.forename: Sergej
authors.initials: S
authors.lastname: Skvortsov
authors.forename: Paul
authors.initials: P
authors.lastname: Debbage
authors.forename: William C S
authors.initials: WC
authors.lastname: Cho
authors.forename: Peter
authors.initials: P
authors.lastname: Lukas
authors.forename: Ira
authors.initials: I
authors.lastname: Skvortsova
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D003131:Combined Modality Therapy; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy; D054778:NM23 Nucleoside Diphosphate Kinases / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000532:radiotherapy*; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000528:radiation effects; D010084:Oxidation-Reduction; D040081:Protein Array Analysis; D020543:Proteome / Q000378:metabolism; D011836:Radiation Tolerance; D020830:rac1 GTP-Binding Protein / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D006360:Heat-Shock Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D020543:Proteome; C107953:RAC1 protein, human; D020830:rac1 GTP-Binding Protein; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase