title: Sustained Release of Diltiazem Hydrochloride from Cross-linked Biodegradable IPN Hydrogel Beads of Pectin and Modified Xanthan Gum.
abstract: Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning colorimetry and scanning electron microscopy were used to characterise the hydrogel beads. The swelling of the hydrogel and the release of drug were relatively low in pH 1.2 buffer solutions. However, higher swelling and drug release were observed in pH 6.8 buffer solutions. The carboxyl functional groups of hydrogels undergo ionisation and the osmotic pressure inside the beads increases resulting in higher swelling and drug release in higher pH. The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices. The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.
authors.forename: T K
authors.initials: TK
authors.lastname: Giri
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.
authors.forename: C
authors.initials: C
authors.lastname: Choudhary
authors.affiliation: Pt. Ravishankar Shukla University, Amanaka G. E. Road, Raipur-492 010, India.
authors.forename: A
authors.initials: A
authors.lastname: Alexander
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.
authors.lastname: Ajazuddin
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.
authors.forename: H
authors.initials: H
authors.lastname: Badwaik
authors.affiliation: Faculty of Pharmacy, Universiti Technologi MARA, Punchak Alam 42300, Malaysia.
authors.forename: M
authors.initials: M
authors.lastname: Tripathy
authors.affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.
authors.forename: D K
authors.initials: DK
authors.lastname: Tripathi
keywords: Entrapment efficiency; biodegradation; modification; release kinetics; swelling ratio