title: Sleep-wake cycle in young and older persons with a lifetime history of mood disorders.
abstract: Considering the marked changes in sleep and circadian rhythms across the lifespan, age may contribute to the heterogeneity in sleep-wake profiles linked to mood disorders. This study aimed to investigate the contributions of age and depression severity to sleep-wake disturbances. The Hamilton Depression Rating Scale (HDRS) was administered to assess current symptoms severity in 238 persons with a history of a mood disorder between 12 and 90 years of age (y.o.). Actigraphy was recorded over five to 22 days. Regression analyses and analyses of variance [age (12-19 y.o., 20-39 y.o., 40-59 y.o., and ≥ 60 y.o.) by depression severity (HDRS< and ≥ 8)] were conducted. The 12-19 y.o. and 20-39 y.o. groups had a delayed sleep schedule and acrophase compared to all other groups. The ≥ 60 y.o. group had a lower rhythmicity and amplitude (p ≤ .006) than the 12-19 y.o. group (p ≤ .046). Participants with a HDRS ≥ 8 spent longer time in bed, had later sleep offset times and had lower circadian rhythmicity than those with a HDRS<8 (p ≤ .036). Younger age and higher HDRS score correlated with later sleep onset and offset times, longer time in bed, higher WASO, lower sleep efficiency and later acrophase (p ≤ .023). Age was a significant predictor of delayed sleep and activity schedules (p ≤ .001). The profile of sleep-wake cycle disturbances associated with mood disorders changes with age, with prominent sleep phase delay during youth and reduced circadian strength in older persons. Conversely, disruptions in sleep consolidation seem more stable across age.
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Rébecca
authors.initials: R
authors.lastname: Robillard
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia ; Healthy Brain Ageing Clinic, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Naismith
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Kristie Leigh
authors.initials: KL
authors.lastname: Smith
authors.affiliation: Concord Clinical School, The University of Sydney, Concord, New South Wales, Australia.
authors.forename: Naomi L
authors.initials: NL
authors.lastname: Rogers
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Django
authors.initials: D
authors.lastname: White
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia ; Healthy Brain Ageing Clinic, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Zoe
authors.initials: Z
authors.lastname: Terpening
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Tony K C
authors.initials: TK
authors.lastname: Ip
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hermens
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Bradley
authors.initials: B
authors.lastname: Whitwell
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Scott
authors.affiliation: Clinical Research Unit, Brain & Mind Research Institute, The University of Sydney, Camperdown, New South Wales, Australia.
authors.forename: Ian B
authors.initials: IB
authors.lastname: Hickie
mesh_terms: D056044:Actigraphy / Q000379:methods; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D001831:Body Temperature / Q000502:physiology; D002648:Child; D002940:Circadian Rhythm / Q000502:physiology*; D003866:Depressive Disorder / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000503:physiopathology*; D010829:Physiological Phenomena / Q000502:physiology; D012890:Sleep / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology; D014851:Wakefulness / Q000502:physiology*; D055815:Young Adult