title: Cytotoxic anthraquinone dimers from Melandrium firmum.
abstract: Two new anthraquinone dimers, melrubiellin A (1) and melrubiellin B (2), were isolated from the aerial part of Melandrium firmum Rohrbach, along with seven known compounds (3-9). The structures of these compounds were elucidated by spectral analyses, including 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) experiments. Compound 1 and 2 exhibited significant cytotoxicity towards HeLa, NCI-H460, Hep G2, Hep 3B and MKN-28 cell lines with IC50 values ranging from 5.26 to 81.16 μM.
authors.affiliation: Key Laboratory of Natural Resources of the Changbai Mountain and Functional Molecules, Yanbian University College of Pharmacy, Yanji, 133002, China.
authors.forename: Chang-Hao
authors.initials: CH
authors.lastname: Zhang
authors.forename: Da-Lei
authors.initials: DL
authors.lastname: Yao
authors.forename: Cheng-Shen
authors.initials: CS
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
authors.forename: Mei
authors.initials: M
authors.lastname: Jin
authors.forename: Ming-Shan
authors.initials: MS
authors.lastname: Zheng
authors.forename: Zhen-Hua
authors.initials: ZH
authors.lastname: Lin
authors.forename: Tie-Feng
authors.initials: TF
authors.lastname: Jin
authors.forename: Gao
authors.initials: G
authors.lastname: Li
mesh_terms: D000880:Anthraquinones / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry; D029751:Silene / Q000737:chemistry*
chemical_list: D000880:Anthraquinones; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; C000605637:melrubiellin A; C000605638:melrubiellin B