title: Effects of metal(loid)-based nanomaterials on essential element homeostasis: the central role of nanometallomics for nanotoxicology.
abstract: The growing use of engineered nanomaterials in both commercial products and biomedical applications leads to increasing exposure for production line workers, consumers and patients. Therefore, the understanding of biological effects induced by nanomaterials is crucial for their safety assessment. An important group of nanomaterials is represented by metal(loid)-based nanoparticles, because of their unique physico-chemical properties. Metal(loid)-based nanoparticles themselves, the related ion release, and their nanometallomes, can potentially interact with essential elements causing dys-homeostasis and adverse biological effects. In this work, we describe the effects of metal(loid)-based nanoparticles on essential element homeostasis. In particular, we consider the most used and promising metal(loid)-based nanoparticles, highlighting that the new emerging concept of nanometallomics is important to disclose the impact of these nanoparticles on human health and the related long-term effects.
authors.affiliation: ECSIN-European Center for the Sustainable Impact of Nanotechnology, Veneto Nanotech S.C.p.A., Viale Porta Adige 45, I-45100 Rovigo, Italy. federico.benetti@venetonanotech.it.
authors.forename: Federico
authors.initials: F
authors.lastname: Benetti
authors.forename: Lisa
authors.initials: L
authors.lastname: Bregoli
authors.forename: Iolanda
authors.initials: I
authors.lastname: Olivato
authors.forename: Enrico
authors.initials: E
authors.lastname: Sabbioni
mesh_terms: D000818:Animals; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D058955:Metalloids / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D008670:Metals / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D053758:Nanoparticles / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*
chemical_list: D058955:Metalloids; D008670:Metals