title: Clinicopathological prognostic factors of oral tongue squamous cell carcinoma: a retrospective study of 202 cases.
abstract: Although several histopathological parameters and grading systems have been described as predictive of the treatment response and outcome of oral squamous cell carcinoma (OSCC), none is universally accepted. A new scoring system, the histological risk model, was recently described to be a powerful predictive tool for recurrence and overall survival in OSCC. The aim of this study was to verify the predictive role of the histological risk model in a cohort of 202 patients at all stages of oral/mobile tongue squamous cell carcinoma (OTSCC). Demographic and clinical data were collected from the medical records and the tumours were evaluated using the histological risk model. Statistical analyses were performed using the χ(2) test, the Kaplan-Meier method, and the Cox regression model. The histological risk model showed no statistical correlation with demographic or clinical parameters and did not Predict the outcome of the OTSCC patients. However, multivariate regression analysis revealed a significant correlation of the clinical disease stage with the disease outcome. Despite major efforts to identify new predictive parameters and histological systems, clinical features are still the most reliable prognostic factors for patients with OTSCC.
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
authors.forename: P C
authors.initials: PC
authors.lastname: Rodrigues
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil; Department of Dentistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: M C C
authors.initials: MC
authors.lastname: Miguel
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: Bagordakis
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
authors.forename: F P
authors.initials: FP
authors.lastname: Fonseca
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
authors.forename: S N
authors.initials: SN
authors.lastname: de Aquino
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
authors.forename: A R
authors.initials: AR
authors.lastname: Santos-Silva
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Lopes
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil.
authors.forename: E
authors.initials: E
authors.lastname: Graner
authors.affiliation: Department of Diagnostics and Oral Medicine, Institute of Dentistry and Oulu University Hospital and Medical Research Center, University of Oulu, Oulu, Finland; Institute of Dentistry, University of Helsinki, Helsinki, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Salo
authors.affiliation: Department of Head and Neck Surgery and Otorhinolaryngology, A.C. Camargo Cancer Center, São Paulo, SP, Brazil.
authors.forename: L P
authors.initials: LP
authors.lastname: Kowalski
authors.affiliation: Department of Oral Diagnosis, School of Dentistry, State University of Campinas, Piracicaba, SP, Brazil. Electronic address: coletta@fop.unicamp.br.
authors.forename: R D
authors.initials: RD
authors.lastname: Coletta
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D060787:Neoplasm Grading; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D014062:Tongue Neoplasms / Q000473:pathology*
keywords: demographic and clinical parameters; histological risk model; oral/mobile tongue squamous cell carcinoma; prognosis