title: Biologically active eremophilane-type sesquiterpenes from Camarops sp., an endophytic fungus isolated from Alibertia macrophylla.
abstract: Two new eremophilane-type sesquiterpenes, xylarenones F (3) and G (4), have been isolated from solid substrate cultures of a Camarops sp. endophytic fungus isolated from Alibertia macrophylla, together with the known compounds xylarenones C (1) and D (2). The structures and relative configurations of 1-4 were elucidated by extensive NMR and HRESIMS spectroscopic analysis. Due to their effects on the respiratory burst of neutrophils, which included inhibition of the reactive oxygen species production, these sesquiterpenes exhibited potential anti-inflammatory and antioxidant properties.
authors.affiliation: Departamento de Química Orgânica, NuBBE - Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Instituto de Química, Universidade Estadual Paulista , Rua Professor Francisco Degni, 55, 14800-900, Araraquara, São Paulo, Brazil.
authors.forename: Juliana R
authors.initials: JR
authors.lastname: Gubiani
authors.forename: Maria L
authors.initials: ML
authors.lastname: Zeraik
authors.forename: Camila M
authors.initials: CM
authors.lastname: Oliveira
authors.forename: Valdecir F
authors.initials: VF
authors.lastname: Ximenes
authors.forename: Cláudio R
authors.initials: CR
authors.lastname: Nogueira
authors.forename: Luiz M
authors.initials: LM
authors.lastname: Fonseca
authors.forename: Dulce H S
authors.initials: DH
authors.lastname: Silva
authors.forename: Vanderlan S
authors.initials: VS
authors.lastname: Bolzani
authors.forename: Angela R
authors.initials: AR
authors.lastname: Araujo
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D001938:Brazil; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors; D019666:Rubiaceae / Q000382:microbiology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014343:Trypan Blue
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D017382:Reactive Oxygen Species; D012717:Sesquiterpenes; D014343:Trypan Blue