title: SIK2 regulates insulin secretion.
abstract: Correct regulation of insulin secretion by the pancreas is crucial for organismal function and survival. The AMPK-related kinase SIK2 (salt-inducible kinase 2) is now shown to be stabilized in pancreatic β-cells following glucose stimulation, leading to improved systemic glucose homeostasis by regulating cellular calcium flux and insulin secretion.
authors.affiliation: Institute of Molecular Health Sciences and the Competence Centre for Systems Physiology and Metabolic Diseases, ETH Zurich, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.
authors.forename: Bengt-Frederik
authors.initials: BF
authors.lastname: Belgardt
authors.affiliation: Institute of Molecular Health Sciences and the Competence Centre for Systems Physiology and Metabolic Diseases, ETH Zurich, Otto-Stern-Weg 7, 8093 Zurich, Switzerland.
authors.forename: Markus
authors.initials: M
authors.lastname: Stoffel
mesh_terms: D000818:Animals; D005260:Female; D050417:Insulin-Secreting Cells / Q000502:physiology*; D008297:Male; D010770:Phosphotransferases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
chemical_list: C492236:Cdk5r1 protein, mouse; C588034:PJA2 protein, mouse; D044767:Ubiquitin-Protein Ligases; D010770:Phosphotransferases; C474808:salt-inducible kinase-2, mouse; D017346:Protein Serine-Threonine Kinases