title: Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model.
abstract: Maladaptive plasticity at corticostriatal synapses plays an important role in the development of levodopa-induced dyskinesia. Recently, it has been shown that synaptic plasticity is closely linked to morphologic changes of dendritic spines. To evaluate morphologic changes of dendritic spines of two types of striatal medium spiny neurons, which project to the internal segment of globus pallidus or the external segment of globus pallidus, in the levodopa-induced dyskinesia model, we used 6-hydroxydopamine-lesioned rats chronically treated with levodopa. Dendritic spines were decreased and became enlarged in the direct pathway neurons of the model of levodopa-induced dyskinesia. The same levodopa treatment to normal rats, in which no dyskinesia was observed, also induced enlargement of dendritic spines, but not a decrease in density of spines in the direct pathway neurons. These results suggest that a loss and enlargement of dendritic spines in the direct pathway neurons plays important roles in the development of levodopa-induced dyskinesia.
authors.affiliation: Department of Neurology, Aomori Prefectural Central Hospital, Aomori City, Aomori, Japan; Department of Neurophysiology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori, Japan.
authors.forename: Haruo
authors.initials: H
authors.lastname: Nishijima
authors.forename: Satoko
authors.initials: S
authors.lastname: Suzuki
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kon
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Funamizu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Ueno
authors.forename: Rie
authors.initials: R
authors.lastname: Haga
authors.forename: Chihiro
authors.initials: C
authors.lastname: Suzuki
authors.forename: Akira
authors.initials: A
authors.lastname: Arai
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kimura
authors.forename: Chieko
authors.initials: C
authors.lastname: Suzuki
authors.forename: Reiko
authors.initials: R
authors.lastname: Meguro
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Miki
authors.forename: Junko
authors.initials: J
authors.lastname: Yamada
authors.forename: Keisuke
authors.initials: K
authors.lastname: Migita
authors.forename: Noritaka
authors.initials: N
authors.lastname: Ichinohe
authors.forename: Shinya
authors.initials: S
authors.lastname: Ueno
authors.forename: Masayuki
authors.initials: M
authors.lastname: Baba
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tomiyama
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000473:pathology*; D049229:Dendritic Spines / Q000473:pathology*; D004195:Disease Models, Animal; D004409:Dyskinesia, Drug-Induced / Q000473:pathology*; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D017072:Neostriatum / Q000473:pathology*; D016501:Neurites / Q000187:drug effects* / Q000378:metabolism; D009474:Neurons / Q000473:pathology; D010300:Parkinson Disease / Q000473:pathology; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects / Q000473:pathology
chemical_list: D007980:Levodopa
keywords: Parkinson's disease; dendritic spine; dyskinesia; morphologic change; synaptic plasticity