title: Necroptosis: molecular signalling and translational implications.
abstract: Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 14, 00161 Rome, Italy.
authors.forename: Claudia
authors.identifier: 0000-0002-5025-5365
authors.initials: C
authors.lastname: Giampietri
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 14, 00161 Rome, Italy.
authors.forename: Donatella
authors.identifier: 0000-0002-0737-8458
authors.initials: D
authors.lastname: Starace
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 14, 00161 Rome, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Petrungaro
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 14, 00161 Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Filippini
authors.affiliation: Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Histology and Medical Embryology, Sapienza University of Rome, Via Scarpa 14, 00161 Rome, Italy.
authors.forename: Elio
authors.identifier: 0000-0002-8776-3515
authors.initials: E
authors.lastname: Ziparo