title: Management of recurrent alveolar soft-part sarcoma of the tongue after external beam radiotherapy with iodine-125 seed brachytherapy.
abstract: BACKGROUND
  Alveolar soft part sarcoma (ASPS) is a rare type of soft tissue sarcoma. The infrequency of ASPS is such that it accounts for <1% of all soft tissue sarcomas and <0.1% of sarcomas concerning the head and neck, primarily those involving the orbit (48%) and tongue (25%). Traditional chemotherapy or radiotherapy of ASPS is often associated with poor outcome, even after comprehensive interventions.
  
  
  RESULTS
  We performed iodine-125 ((125) I) seed brachytherapy under ultrasound guidance through a submandibular puncture in a 4-year-old boy with recurrent ASPS of the tongue. The prescription dose was 120 Gy; therefore, 35 (125) I seeds were implanted with 0.77 mCi per seed, the total amount of activity being 26.95 mCi. CT scans confirmed a complete response after the treatment.
  
  
  CONCLUSIONS
  Our patient now has a recurrent-free survival of >30 months, an amount of time longer than the median rate described in the literature.
authors.affiliation: Department of Radiation Oncology, Peking University Third Hospital, Beijing, People's Republic of China.
authors.forename: Na
authors.initials: N
authors.lastname: Meng
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Zhang
authors.forename: Anyan
authors.initials: A
authors.lastname: Liao
authors.forename: Suqing
authors.initials: S
authors.lastname: Tian
authors.forename: Weiqiang
authors.initials: W
authors.lastname: Ran
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Jun Jie
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D001918:Brachytherapy; D002675:Child, Preschool; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000532:radiotherapy*; D018234:Sarcoma, Alveolar Soft Part / Q000175:diagnosis / Q000532:radiotherapy*; D014062:Tongue Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*
chemical_list: D007457:Iodine Radioisotopes
keywords: 125I seed; alveolar soft-part sarcoma; brachytherapy; outcome; ultrasound guidance