title: Tau oligomers as potential targets for early diagnosis of tauopathy.
abstract: The discovery of tau mutations in frontotemporal dementia has been a key event in neurodegenerative disease research. The rTg4510 mouse line expressing human tau with P301L FTDP-17-tau mutation has been established to understand the role of tau in neurodegeneration. Our histological analyses with tau antibodies and fluorescent tau ligands on rTg4510 mice revealed that tau oligomer formation was distinct from tangle formation. While in vivo imaging of mature tangles is now available, imaging biomarkers for tau oligomers would be useful for clarifying their roles in neurotoxicity and for diagnosing early-stage tau pathology.
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences, Chiba-shi, Chiba, Japan Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL, USA.
authors.forename: Naruhiko
authors.initials: N
authors.lastname: Sahara
authors.affiliation: Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Ren
authors.affiliation: Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, Grand Rapids, MI, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Ward
authors.affiliation: Department of Translational Science and Molecular Medicine, Michigan State University College of Human Medicine, Grand Rapids, MI, USA.
authors.forename: Lester I
authors.initials: LI
authors.lastname: Binder
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences, Chiba-shi, Chiba, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Suhara
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences, Chiba-shi, Chiba, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Higuchi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D042241:Early Diagnosis; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008822:Mice, Transgenic; D016874:Neurofibrillary Tangles / Q000378:metabolism* / Q000473:pathology; D024801:Tauopathies / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D016875:tau Proteins
keywords: Antibody; tau ligand; tau oligomers; tau protein; transgenic mice