title: The first report on flavonoid isolation from Annona crassiflora Mart.
abstract: Annona crassiflora, a native tree from Brazilian Cerrado, is reported to possess several ethnomedical uses. Here, we report the isolation and unambiguous characterisation of the flavonoids quercetin-3-O-β-D-glucopyranosil(1 → 6)-O-α-L-arabinoside (1), known as peltatoside, kaempferol-3-O-β-D-galactopyranoside (2), quercetin-3-O-β-D-galactopyranoside (3), quercetin-3-O-β-L-arabinopiranoside (4) and the ( - )-epicatechin (5) from the hydroalcoholic portion of the leaf ethanolic extract. Their structures were elucidated by using 1D and 2D NMR, ESI-MS, UV/Vis spectroscopy, optical rotation analysis and literature data comparison. The leaf ethanolic extract and its isolated compounds were evaluated by using antimicrobial, antioxidant and larvicidal assays, expressing antimicrobial and antioxidant activities. This is the first report on flavonoid isolation from A. crassiflora.
authors.affiliation: a Departamento de Química , Instituto de Ciências Exatas, Universidade Federal de Minas Gerais , Av. Antînio Carlos, 6627, Belo Horizonte , Minas Gerais CEP 31270-901 , Brazil.
authors.forename: Gisele Avelar
authors.initials: GA
authors.lastname: Lage
authors.forename: Felipe da Silva
authors.initials: Fda S
authors.lastname: Medeiros
authors.forename: Werônica de Lima
authors.initials: Wde L
authors.lastname: Furtado
authors.forename: Jacqueline Aparecida
authors.initials: JA
authors.lastname: Takahashi
authors.forename: José Dias
authors.initials: JD
authors.lastname: de Souza Filho
authors.forename: Lúcia Pinheiro Santos
authors.initials: LP
authors.lastname: Pimenta
mesh_terms: D031041:Annona; D000975:Antioxidants / Q000737:chemistry; D001409:Bacillus cereus / Q000187:drug effects; D001938:Brazil; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005697:Galactosides; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D044949:Kaempferols; D008826:Microbial Sensitivity Tests; D018515:Plant Leaves / Q000737:chemistry; D011794:Quercetin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012486:Salmonella typhimurium / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D005697:Galactosides; D006027:Glycosides; D044949:Kaempferols; C508165:quercetin-3-O-beta-D-galactopyranoside; C000592193:quercetin-3-O-beta-D-glucopyranosil(1-6)-O-alpha-L-arabinoside; C006552:kaempferol; D011794:Quercetin; C041477:3-hydroxyflavone
keywords: Annona crassiflora; Annonaceae; antimicrobial activity; antioxidant activity; flavonoids; larvicidal activity