title: Prospective echocardiographic assessment of cardiac structure and function in Chinese persons living with HIV.
abstract: BACKGROUND
  Persons living with human immunodeficiency virus (HIV) are at increased risk of developing cardiovascular disease. Few studies have focused on echocardiographic abnormalities in this population.
  
  
  METHODS
  China AIDS Clinical Trial 0810 is a prospective, multicenter cohort study of persons living with HIV (PLWH). We performed an echocardiography substudy of 325 PLWH. We examined the prevalence of left ventricular systolic dysfunction (LVSD), diastolic dysfunction (DD), pulmonary arterial hypertension (PAH), and increased left ventricular mass (ILVM) in antiretroviral therapy (ART)-naive PLWH at baseline and week 48 after initiation of ART.
  
  
  RESULTS
  Compared with age- and sex-matched healthy controls, PLWH had a higher prevalence of DD (16.5% vs 7.2%, P < .027) and a marginally significant higher prevalence of LVSD (7.3% vs 2.1%, P = .056). The increase in the prevalence of DD from baseline to week 48 in PLWH was marginally significant (P = .056). No significant difference was observed in the prevalence of LVSD, PAH, or ILVM at baseline and week 48 in PLWH. In logistic regression analysis of all participants, age was significantly associated with LVSD; HIV infection, age, and hypertension were associated with DD whereas HIV infection and hypertension were associated with ILVM at baseline. Logistic regression analysis of PLWH showed that only age was significantly associated with LVSD and DD.
  
  
  CONCLUSIONS
  The prevalence of echocardiographic abnormalities was significantly higher in ART-naive PLWH than in controls. HIV infection was significantly associated with cardiac abnormalities. No significant change in echocardiographic abnormalities was observed after 48 weeks of ART. Longer-term prospective studies are warranted.
authors.affiliation: Department of Infectious Disease.
authors.forename: Ling
authors.initials: L
authors.lastname: Luo
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.forename: Taisheng
authors.initials: T
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Lv
authors.forename: Huanling
authors.initials: H
authors.lastname: Wang
authors.forename: Fuping
authors.initials: F
authors.lastname: Guo
authors.forename: Yang
authors.initials: Y
authors.lastname: Han
authors.forename: Jing
authors.initials: J
authors.lastname: Xie
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Qiu
authors.forename: Yanling
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Song
authors.forename: Ting
authors.initials: T
authors.lastname: Zhu
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Yicong
authors.initials: Y
authors.lastname: Ye
authors.forename: Yun
authors.initials: Y
authors.lastname: He
authors.forename: Hongzhou
authors.initials: H
authors.lastname: Lu
authors.forename: Aiqiong
authors.initials: A
authors.lastname: Huang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Tang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.forename: Guiju
authors.initials: G
authors.lastname: Gao
authors.forename: Junkang
authors.initials: J
authors.lastname: Lei
authors.forename: Xinhua
authors.initials: X
authors.lastname: Wu
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Sun
authors.forename: Jinsong
authors.initials: J
authors.lastname: Bai
authors.forename: Kunli
authors.initials: K
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002681:China; D015331:Cohort Studies; D004452:Echocardiography; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006331:Heart Diseases / Q000000981:diagnostic imaging* / Q000209:etiology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000209:etiology; D008875:Middle Aged; D011446:Prospective Studies; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology* / Q000821:virology; D055815:Young Adult
keywords: ART; HIV; cardiac abnormalities; echocardiography