title: Soluble form of receptor for advanced glycation end products is associated with obesity and metabolic syndrome in adolescents.
abstract: The aim of this cross-sectional study was to investigate the relationship between soluble form of receptor for advanced glycation end products (sRAGE), obesity, and metabolic syndrome (MetS) in adolescents. A total of 522 male and 561 female adolescents were enrolled into the final analyses. Anthropometric parameters, blood pressure, blood biochemistry, fasting insulin, and plasma sRAGE levels were measured. In males, sRAGE was significantly and inversely correlated with waist circumference (WC), body mass index (BMI), systolic blood pressure, triglyceride (TG), low density lipoprotein cholesterol (LDL-C), and homeostasis model assessment-insulin resistance (HOMA-IR). Only WC and BMI were significantly and inversely correlated with sRAGE in females. Using linear regression analysis adjusting for age and gender, significant association was found between sRAGE and WC, BMI, TG, LDL-C, and HOMA-IR in adolescents of either gender (P < 0.05). This association was abolished when further adjusting BMI. In addition, sRAGE was significantly and inversely correlated with the increasing number of components of MetS in males (P for trend = 0.006) but not in females (P for trend = 0.422). In conclusion, plasma sRAGE is associated with obesity and MetS among adolescents. BMI may be the most important determinant of sRAGE levels in adolescents.
authors.affiliation: Department of Internal Medicine, Tri-Service General Hospital Songshan Branch, Taipei 10581, Taiwan ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 11490, Taiwan.
authors.forename: Chih-Tsueng
authors.identifier: 0000-0002-1918-5186
authors.initials: CT
authors.lastname: He
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 11490, Taiwan.
authors.forename: Chien-Hsing
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 11490, Taiwan.
authors.forename: Chang-Hsun
authors.initials: CH
authors.lastname: Hsieh
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 11490, Taiwan.
authors.forename: Fone-Ching
authors.identifier: 0000-0002-9745-6404
authors.initials: FC
authors.lastname: Hsiao
authors.affiliation: College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
authors.forename: Philip
authors.identifier: 0000-0001-8456-6199
authors.initials: P
authors.lastname: Kuo
authors.affiliation: School of Public Health, National Defense Medical Center, No. 161, Section 6, Minquan E. Road, Neihu District, Taipei City 11490, Taiwan.
authors.forename: Nain-Feng
authors.identifier: 0000-0003-1513-4995
authors.initials: NF
authors.lastname: Chu
authors.affiliation: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No. 325, Section 2, Chenggong Road, Neihu District, Taipei City 11490, Taiwan.
authors.forename: Yi-Jen
authors.identifier: 0000-0001-5318-9001
authors.initials: YJ
authors.lastname: Hung