title: Hydrophilic molybdenum oxide nanomaterials with controlled morphology and strong plasmonic absorption for photothermal ablation of cancer cells.
abstract: The molybdenum oxide nanosheets have shown strong localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region. However, the long alky chains of ligands made them hydrophobic and less biocompatible. To meet the requirements of molybdenum based nanomaterials for use as a future photothermal therapy, a simple hydrothermal route has been developed for hydrophilic molybdenum oxide nanospheres and nanoribbons using a molybdenum precursor and poly(ethylene glycol) (PEG). First, molybdenum oxide nanomaterials prepared in the presence of PEG exhibit strong localized surface plasmon resonance (LSPR) absorption in near-infrared (NIR) region, compared with that of no PEG. Second, elevation of synthetic temperature leads to a gradual transformation of molybdenum oxide nanospheres into nanoribbons, entailing the evolution of an intense LSPR absorption in the NIR region. Third, as-prepared molybdenum oxide nanomaterials coated with PEG possess a hydrophilic property and thus can be directly used for biological applications without additional post treatments. Moreover, molybdenum oxide nanoribbons as a model of photothermal materials can efficiently convert the 980 nm wavelength laser energy into heat energy, and this localized hyperthermia produces the effective thermal ablation of cancer cells, meaning a potential photothermal material.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University , Shanghai 201620, China.
authors.forename: Guosheng
authors.initials: G
authors.lastname: Song
authors.forename: Jia
authors.initials: J
authors.lastname: Shen
authors.forename: Feiran
authors.initials: F
authors.lastname: Jiang
authors.forename: Ronggui
authors.initials: R
authors.lastname: Hu
authors.forename: Wenyao
authors.initials: W
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: An
authors.forename: Rujia
authors.initials: R
authors.lastname: Zou
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Chen
authors.forename: Zongyi
authors.initials: Z
authors.lastname: Qin
authors.forename: Junqing
authors.initials: J
authors.lastname: Hu
mesh_terms: D000042:Absorption; D045744:Cell Line, Tumor; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053685:Laser Therapy / Q000295:instrumentation*; D008982:Molybdenum / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry* / Q000528:radiation effects; D009369:Neoplasms / Q000737:chemistry* / Q000628:therapy*; D010087:Oxides / Q000737:chemistry*; D020349:Surface Plasmon Resonance
chemical_list: D010087:Oxides; D008982:Molybdenum