title: A novel method of defective vascular reconstruction using 2-octyl-cyanoacrylate and homemade prosthetic component.
abstract: BACKGROUND
  Currently, adhesive technique is popular in vascular repair but not widely used for defective vessels. This study aimed to determine the feasibility and effectiveness of repairing defective vessels with 2-octyl-cyanoacrylate and a homemade prosthetic component.
  
  
  METHODS
  Homemade prosthetic component consisting of expanded polytetrofluoroethylene (ePTFE), terylene film, and homemade soluble hollow stent mixed with adhesive can replace autologous graft and suture in repairing defective vessels, can fix vessels better using the stent without occlusive bleeding. Forty male mongrel dogs were used, 20 for biomechanical tests and 20 for animal experiments. In the biomechanical test, dogs were randomly divided into two groups (n = 10 each), one group repaired on the two sides of the carotid arteries with 2-octyl-cyanoacrylate and homemade component and another group repaired with suture and ePTFE. Of the 40 specimens, 10 were used for adhesive and 10 for suture specimens for tension strength test, whereas the remaining specimens were used for bursting pressure test. In animal experiments, dogs were also divided into adhesive and suture groups (n = 10), only of the left carotid artery. Recording the operational time, bleeding or not. Vessels were tested using color Doppler ultrasound, the inner diameter was measured, and the degree of stenosis at 8 weeks was evaluated digital subtraction angiography (DSA) were also performed. Specimens were then analyzed histologically.
  
  
  RESULTS
  In the adhesive and suture groups, the specimens could afford atension strength of (23.80 ± 1.51) N versus (24.60 ± 1.08) N (P > 0.05), the bursting pressure was (52.03 ± 2.43) kPa versus (50.04 ± 3.51) kPa (P > 0.05), and the mean time of anastomosis was (15.20 ± 0.55) minutes versus (25.97 ± 0.58) minutes (P < 0.05). One dog in the adhesive group was bleeding from the suture. One dog from each group presented with thrombosis at 1 week. After measuring using ultrasound, the stenosis degree of all dogs were no more than 30% except the two thromboses. DSA and histological observation showed no obvious difference between the two groups.
  
  
  CONCLUSIONS
  Defective vascular anastomosis with 2-octyl-cyanoacrylate and our homemade prosthetic component is feasible, effective, timesaving, and easy to master.
authors.affiliation: Department of Orthopedics, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Xiangdang
authors.initials: X
authors.lastname: Liang
authors.affiliation: Department of Orthopedics, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Hongfei
authors.initials: H
authors.lastname: Cai
authors.affiliation: Department of Orthopedics, Chinese No. 252 Hospital of People's Liberation Army, Baoding, Hebei 071000, China.
authors.forename: Geng
authors.initials: G
authors.lastname: Sun
authors.affiliation: Department of Orthopedics, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Zihao
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Department of Orthopedics, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Orthopedics, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Email: lxd301@263.net.
authors.forename: Peifu
authors.initials: P
authors.lastname: Tang
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods*; D000818:Animals; D002339:Carotid Arteries / Q000601:surgery*; D003487:Cyanoacrylates / Q000627:therapeutic use*; D004285:Dogs; D008297:Male; D019651:Plastic Surgery Procedures / Q000379:methods*; D014656:Vascular Surgical Procedures / Q000379:methods*
chemical_list: D003487:Cyanoacrylates; C100832:octyl 2-cyanoacrylate