title: Evaluation of paediatric patients with protein losing enteropathy a single centre experience.
abstract: OBJECTIVE
  The aim of the study is to evaluate paediatric patients with protein losing enteropathy (PLE).
  
  
  METHODS
  Fourteen cases diagnosed as PLE were evaluated in terms ofaetiologies, diagnostic methods, laboratory findings, treatment procedures and long-term prognosis.
  
  
  RESULTS
  Four of the cases had coeliac disease, three intestinal lymphangiectasia, three giardia infection, one H pylori infection and three cytomegalovirus (CMV) infection. Histopathological examinations of duodenum specimens revealed total villous atrophy in four cases, lymphatic dilatation in three cases, severe nodular appearance in four cases and no pathology in four cases. All of the cases except patients with intestinal lymphangiectasia were controlled by the appropriate treatment given for the underlying disease. The cases with CMV infection were treated with only supportive treatment and gancyclovir therapy was not needed.
  
  
  CONCLUSIONS
  When proteinuria is not detected in well-appearing children admitted with oedema, PLE must be considered.
authors.affiliation: Department of Paediatric Gastroenterology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Urganci
authors.affiliation: Department of Paediatrics, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
authors.forename: S G
authors.initials: SG
authors.lastname: Gulec
authors.affiliation: Department of Paediatrics, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Kalyoncu
authors.affiliation: Department of Paediatrics, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Karaman
mesh_terms: D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D004386:Duodenum / Q000473:pathology; D005260:Female; D005873:Giardiasis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D016480:Helicobacter pylori; D006801:Humans; D007019:Hypoproteinemia / Q000209:etiology; D007223:Infant; D008201:Lymphangiectasis, Intestinal / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D011504:Protein-Losing Enteropathies / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D012189:Retrospective Studies