title: [Micro/nano-engineering to control growth of neuronal cells and tissue engineering applied to the central nervous system].
abstract: Central nervous system pathologies are often characterized by the loss of cell populations. A promising therapy now being developed consists in using bioactive materials, associating grafted cells to biopolymers which provide a scaffold for the in vitro building of new tissues, to be implanted in vivo. In the present article, the state of the art of this field, at crossroads between microtechnology and neuroscience, is described in detail; thereafter our own approach and results about interactions between adult human neural stem cells and microstructured polymers are summarized and discussed. In a second part, some central nervous system repair strategies, based on cerebral tissue engineering, are presented. We will report the main results of our studies to work out and characterize in vivo a cerebral bioprosthesis.
authors.affiliation: LAAS, CNRS &amp; Université de Toulouse (UPS, INSA, IAES), 7 avenue du Colonel Roche, 31077 Toulouse, France.
authors.forename: Amélie
authors.initials: A
authors.lastname: Béduer
authors.affiliation: INSERM, Imagerie Cérébrale et Handicaps Neurologiques UMR 825, 31059 Toulouse, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Vaysse
authors.affiliation: INSERM, Imagerie Cérébrale et Handicaps Neurologiques UMR 825, 31059 Toulouse, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Loubinoux
authors.affiliation: LAAS, CNRS &amp; Université de Toulouse (UPS, INSA, IAES), 7 avenue du Colonel Roche, 31077 Toulouse, France.
authors.forename: Christophe
authors.initials: C
authors.lastname: Vieu
mesh_terms: D000328:Adult; D002448:Cell Adhesion; D049109:Cell Proliferation; D048430:Cell Shape; D002490:Central Nervous System / Q000166:cytology* / Q000502:physiology; D006801:Humans; D055616:Microtechnology / Q000379:methods*; D036103:Nanotechnology / Q000379:methods*; D009416:Nerve Regeneration; D009474:Neurons / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*