title: Role of mesenchymal stem cells in cell life and their signaling.
abstract: Mesenchymal stem cells (MSCs) have various roles in the body and cellular environment, and the cellular phenotypes of MSCs changes in different conditions. MSCs support the maintenance of other cells, and the capacity of MSCs to differentiate into several cell types makes the cells unique and full of possibilities. The involvement of MSCs in the epithelial-mesenchymal transition is an important property of these cells. In this review, the role of MSCs in cell life, including their application in therapy, is first described, and the signaling mechanism of MSCs is investigated for a further understanding of these cells.
authors.affiliation: Shihori Tanabe, National Institute of Health Sciences, Tokyo 158-8501, Japan.
authors.forename: Shihori
authors.initials: S
authors.lastname: Tanabe
keywords: Application; Differentiation; Mesenchymal stem cell; Self-renewal; Stem cell