title: Activation of monocyte-derived cells in the bone marrow of myelodysplastic syndrome.
abstract: OBJECTIVE
  To study the relationship between monocyte/histiocyte activation and myelodysplastic syndrome (MDS).
  
  
  METHODS
  Analyzing ultrastructure and myeloperoxidase reaction of nucleated cells in bone marrow from 59 cases of MDS by transmission electron microscopy. Four groups of MDS were subdivided on the basis of their content of activated inflammatory cells - morbid hematopoiesis with minimal inflammatory cell activation (MH-MICA); MDS with monocytic system activation (MSA); MDS with lymphocyte activation (LCA); and MDS with granulocyte activation (GCA).
  
  
  RESULTS
  About 20, 22, 7, and 10 cases were classified as MH-MICA (34%), MSA (37%), LCA (12%), and GCA sub-types (17%), respectively. About 3, 5, 0, and 3 cases from MH-MICA, MSA, LCA, and GCA, respectively, underwent leukemic transformation within 2 years.
  
  
  CONCLUSIONS
  The findings suggest that activation of inflammatory cells in bone marrow is an important feature of MDS, and that monocytes/histocytes are perhaps the most prominent cellular participants in the pathogenesis of MDS.
authors.affiliation: State Key Laboratory of Experimental Haematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Tianjin , China and.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Ru
authors.forename: Shuxu
authors.initials: S
authors.lastname: Dong
authors.forename: Huamei
authors.initials: H
authors.lastname: Zhang
authors.forename: Shixuan
authors.initials: S
authors.lastname: Zhao
authors.forename: Kun
authors.initials: K
authors.lastname: Ru
authors.forename: Guoguang
authors.initials: G
authors.lastname: Zheng
authors.forename: Zhijie
authors.initials: Z
authors.lastname: Xiao
authors.forename: Brian
authors.initials: B
authors.lastname: Eyden
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D009000:Monocytes / Q000473:pathology*; D009190:Myelodysplastic Syndromes / Q000473:pathology*; D055815:Young Adult
keywords: Bone marrow; inflammatory cell; monocyte; myelodysplastic syndrome