title: Mung bean decreases plasma cholesterol by up-regulation of CYP7A1.
abstract: Our results affirmed that supplementation of 1 or 2% mung bean could decrease plasma total cholesterol and triacylglycerol level. Mung bean increased mRNA 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase. Most importantly, mung bean increased not only the protein level of cholesterol-7α-hydroxylase (CYP7A1) but also mRNA CYP7A1. It was concluded that the hypocholesterolemic activity of mung bean was most probable mediated by enhancement of bile acid excretion and up-regulation of CYP7A1.
authors.affiliation: Institute of Crop Science, Chinese Academy of Agricultural Sciences, No.80 South Xueyuan Road, Haidian District, Beijing, 100081, People's Republic of China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yao
authors.forename: Liu
authors.initials: L
authors.lastname: Hao
authors.forename: Zhenxing
authors.initials: Z
authors.lastname: Shi
authors.forename: Lixia
authors.initials: L
authors.lastname: Wang
authors.forename: Xuzhen
authors.initials: X
authors.lastname: Cheng
authors.forename: Suhua
authors.initials: S
authors.lastname: Wang
authors.forename: Guixing
authors.initials: G
authors.lastname: Ren
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000235:genetics / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000378:metabolism; D006224:Cricetinae; D007887:Fabaceae; D005243:Feces; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors / Q000235:genetics / Q000378:metabolism; D011973:Receptors, LDL / Q000235:genetics / Q000378:metabolism; D051782:Sterol Regulatory Element Binding Protein 2 / Q000235:genetics / Q000378:metabolism; D013261:Sterols / Q000493:pharmacokinetics; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation
chemical_list: D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D011973:Receptors, LDL; D051782:Sterol Regulatory Element Binding Protein 2; D013261:Sterols; D014280:Triglycerides; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase