title: Investigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus.
abstract: OBJECTIVE
  Leukocytosis is thought to be directly associated with the pathogenesis of atherosclerosis and metabolic syndrome. Increased white blood cell (WBC) count is related to cardiovascular disease in patients with type 2 diabetes mellitus; raised neutrophil lymphocyte ratio (NLR) is associated with metabolic syndrome. There is little information, however, concerning a correlation between glycosylated haemoglobin (HbA1c) and NLR. The aim of the present study was to investigate the relationship between NLR and blood glucose regulation.
  
  
  METHODS
  This retrospective study was conducted in patients with type 2 diabetes mellitus, divided into two groups according to HbA1c levels: group 1, HbA1c levels ≤ 7%; group 2, HbA1c levels > 7%. Venous WBC, neutrophil and lymphocyte counts were determined.
  
  
  RESULTS
  Of 71 patients included, fasting serum glucose, neutrophil and WBC counts were significantly higher in group 2 compared with group 1. NLR had a positive correlation with HbA1c.
  
  
  CONCLUSIONS
  There may be a significant relationship between NLR and blood glucose regulation. The authors propose that increased NLR may be associated with elevated HbA1c in patients with type 2 diabetes mellitus.
authors.affiliation: Department of Medical Physiology, Medical Faculty, Mustafa Kemal University, Hatay, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Sefil
authors.forename: Kemal Turker
authors.initials: KT
authors.lastname: Ulutas
authors.forename: Recep
authors.initials: R
authors.lastname: Dokuyucu
authors.forename: Ahmet Taner
authors.initials: AT
authors.lastname: Sumbul
authors.forename: Erhan
authors.initials: E
authors.lastname: Yengil
authors.forename: Abdullah Erman
authors.initials: AE
authors.lastname: Yagiz
authors.forename: Erkan
authors.initials: E
authors.lastname: Yula
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ustun
authors.forename: Cumali
authors.initials: C
authors.lastname: Gokce
mesh_terms: D001786:Blood Glucose / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007964:Leukocytosis / Q000276:immunology*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology* / Q000276:immunology; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Glycosylated haemoglobin (HbA1c); diabetes mellitus; neutrophil lymphocyte ratio