title: A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease.
abstract: Rheumatoid arthritis (RA) is a systemic inflammatory disorder affecting approximately 1.3 million adults in the United States. Approximately 10% of these individuals with RA have clinically evident interstitial lung disease (RA-ILD), and an additional one-third demonstrate subclinical ILD on chest CT scan. The risk of death for individuals with RA-ILD is three times higher than for patients with RA without ILD, with a median survival after ILD diagnosis of only 2.6 years. Despite the high prevalence and mortality of RA-ILD, little is known about its molecular features and its natural history. At present, we lack a standard validated approach to the definition, diagnosis, risk stratification, and management of RA-ILD. In this perspective, we discuss the importance of clinical and translational research and how ongoing research efforts can address important gaps in our knowledge over the next few years. Furthermore, recommendations are made to design multicenter collaborative studies that will expedite the development of clinical trials designed to decrease the significant morbidity and mortality associated with RA-ILD.
authors.affiliation: Division of Pulmonary and Critical Care Medicine Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Tracy J
authors.initials: TJ
authors.lastname: Doyle
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California San Francisco School of Medicine, San Francisco, CA.
authors.forename: Joyce S
authors.initials: JS
authors.lastname: Lee
authors.affiliation: Division of Rheumatology, Immunology, and Allergy Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: Paul F
authors.initials: PF
authors.lastname: Dellaripa
authors.affiliation: Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
authors.forename: James A
authors.initials: JA
authors.lastname: Lederer
authors.affiliation: Division of Rheumatology, Mayo Clinic College of Medicine, Rochester, MN.
authors.forename: Eric L
authors.initials: EL
authors.lastname: Matteson
authors.affiliation: Division of Rheumatology, National Jewish Health and University of Colorado, Denver, CO.
authors.forename: Aryeh
authors.initials: A
authors.lastname: Fischer
authors.affiliation: Division of Rheumatology, University of Miami Miller School of Medicine, Miami, FL.
authors.forename: Dana P
authors.initials: DP
authors.lastname: Ascherman
authors.affiliation: Division of Pulmonary Medicine, University of Miami Miller School of Medicine, Miami, FL.
authors.forename: Marilyn K
authors.initials: MK
authors.lastname: Glassberg
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine, Rochester, MN.
authors.forename: Jay H
authors.initials: JH
authors.lastname: Ryu
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
authors.forename: Sonye K
authors.initials: SK
authors.lastname: Danoff
authors.affiliation: Autoimmune Lung Center and Interstitial Lung Disease Program, National Jewish Health, Denver, CO.
authors.forename: Kevin K
authors.initials: KK
authors.lastname: Brown
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of California San Francisco School of Medicine, San Francisco, CA.
authors.forename: Harold R
authors.initials: HR
authors.lastname: Collard
authors.affiliation: Lovelace Respiratory Research Institute, Albuquerque, NM. Electronic address: irosas@rics.bwh.harvard.edu.
authors.forename: Ivan O
authors.initials: IO
authors.lastname: Rosas
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications*; D003937:Diagnosis, Differential; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000209:etiology*; D014057:Tomography, X-Ray Computed; D057170:Translational Research, Biomedical / Q000379:methods*