title: Association Study of FOS-Like Antigen-2 Promoter Polymorphisms With Papillary Thyroid Cancer in Korean Population.
abstract: OBJECTIVE
  FOS-like antigen-2 (FOSL-2), a member of the FOS gene family, encode leucine zipper proteins that can heterodimerize with proteins of Jun family. Thus, activating protein (AP)-1 transcription factor is formed, has a crucial role in proliferation, differentiation and apoptosis of normal tissue as well as oncogenic transformation and progression. We performed an association study of single nucleotide polymorphisms (SNPs) in the FOSL-2 with papillary thyroid cancer (PTC). We also estimated the relationships between the SNPs and the clinicopathologic characteristics of PTC.
  
  
  METHODS
  One promoter SNPs (rs925255) of FOSL-2 gene were genotyped with direct sequencing method in 94 PTC and 213 controls. PTC patients were dichotomized and compared with respect to clinical parameters of PTC. Genetic data were analyzed using Helixtree, SNPAnalyzer, SNPStats. Multivariate logistic regression analysis was fulfilled to evaluate the genetic effect with adjustment for age and sex.
  
  
  RESULTS
  SNP (rs925255) in FOSL-2 showed a significant association (codominant 1 model [G/G vs. A/G]: odds ratio [OR], 0.531, 95% confidence interval [CI], 0.293 to 0.96, P=0.036; dominant model: OR, 0.50, 95% CI, 0.28 to 0.89, P=0.015) with PTC. The frequency of allele G in rs925255 was also significantly associated with PTC (OR, 0.59; 95% CI, 0.34 to 0.91; P=0.02). But we fail to prove significant association between this polymorphism (rs925255) and clinico-pathological parameters.
  
  
  CONCLUSIONS
  Our findings suggest that the rs925255 SNP and its allele G show significant association with the PTC in Korean population.
authors.affiliation: Department of Otorhinolaryngology Head & Neck Surgery, VHS Medical Center, Seoul, Korea.
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Kim
authors.affiliation: Department of Otorhinolaryngology Head & Neck Surgery, VHS Medical Center, Seoul, Korea.
authors.forename: Choon Dong
authors.initials: CD
authors.lastname: Kim
authors.affiliation: Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
authors.forename: Joo Ho
authors.initials: JH
authors.lastname: Chung
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Ilsong Memorial Institute of Head and Neck Cancer, Hallym University College of Medicine, Seoul, Korea.
authors.forename: Kee Hwan
authors.initials: KH
authors.lastname: Kwon
keywords: FOS-like antigen-2; Papillary thyroid cancer; Polymorphism