title: Small regulatory RNAs from low-GC Gram-positive bacteria.
abstract: Small regulatory RNAs (sRNAs) that act by base-pairing were first discovered in so-called accessory DNA elements--plasmids, phages, and transposons--where they control replication, maintenance, and transposition. Since 2001, a huge body of work has been performed to predict and identify sRNAs in a multitude of bacterial genomes. The majority of chromosome-encoded sRNAs have been investigated in E. coli and other Gram-negative bacteria. However, during the past five years an increasing number of sRNAs were found in Gram-positive bacteria. Here, we outline our current knowledge on chromosome-encoded sRNAs from low-GC Gram-positive species that act by base-pairing, i.e., an antisense mechanism. We will focus on sRNAs with known targets and defined regulatory mechanisms with special emphasis on Bacillus subtilis.
authors.affiliation: Friedrich-Schiller-Universität Jena; Biologisch-Pharmazeutische Fakultät; AG Bakteriengenetik; Philosophenweg 12; Jena, Germany.
authors.forename: Sabine
authors.initials: S
authors.lastname: Brantl
authors.affiliation: Mikrobiologie; TU Kaiserslautern; Paul-Ehrlich-Str. 23; D-67663 Kaiserslautern, Germany.
authors.forename: Reinhold
authors.initials: R
authors.lastname: Brückner
mesh_terms: D001482:Base Composition; D020029:Base Pairing; D015964:Gene Expression Regulation, Bacterial; D006094:Gram-Positive Bacteria / Q000235:genetics* / Q000378:metabolism; D016372:RNA, Antisense / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D012329:RNA, Bacterial / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D058727:RNA, Small Untranslated / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism
chemical_list: D016372:RNA, Antisense; D012329:RNA, Bacterial; D058727:RNA, Small Untranslated; D016601:RNA-Binding Proteins
keywords: Bacillus subtilis; Streptococcus pneumoniae; base-pairing sRNA; low GC Gram-positive bacteria; small regulatory RNA