title: The different molecular mechanisms of mitophagy between yeast and mammals.
abstract: The mitochondrion is the site of energy metabolism inside the cell; which produces ATP for vital activities. The accumulation of damaged mitochondria affects cell survival, these organelles are removed via mitophagy to maintain cell vitality. Currently, mitophagy is a hot topic in life science research. Understanding the role of mitophagy in pathogenesis and its association with the genesis of disease is important for developing treatments for many human diseases. Here, we summarize current progress in the study of mitophagy and describe the different molecular mechanisms of mitophagy between yeast and mammals, as well as related diseases.
authors.affiliation: Department of Pharmacology, Zhejiang University of Technology, Hangzhou Chaowang Road 18#, Zhejiang, 310014, P.R. China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Song
authors.affiliation: Department of Pharmacology, Zhejiang University of Technology, Hangzhou Chaowang Road 18#, Zhejiang, 310014, P.R. China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Xiao
authors.affiliation: Department of Life Sciences Beking University , Yiheyuan Road 5#, Haidian District, Beijing, 100871, P.R. China.
authors.forename: Jia-Ming
authors.initials: JM
authors.lastname: Wang
authors.affiliation: Third hospital of Hangzhou, West Lake Road 38#, 310016, P.R. China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000818:Animals; D001343:Autophagy; D004734:Energy Metabolism; D006801:Humans; D008322:Mammals / Q000378:metabolism*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D063154:Mitochondrial Dynamics; D033681:Mitochondrial Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D063306:Mitophagy / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology*
chemical_list: D033681:Mitochondrial Membrane Transport Proteins