title: Recent progress in the genetics of spontaneously hypertensive rats.
abstract: The spontaneously hypertensive rat (SHR) is the most widely used animal model of essential hypertension and accompanying metabolic disturbances. Recent advances in sequencing of genomes of BN-Lx and SHR progenitors of the BXH/HXB recombinant inbred (RI) strains as well as accumulation of multiple data sets of intermediary phenotypes in the RI strains, including mRNA and microRNA abundance, quantitative metabolomics, proteomics, methylomics or histone modifications, will make it possible to systematically search for genetic variants involved in regulation of gene expression and in the etiology of complex pathophysiological traits. New advances in manipulation of the rat genome, including efficient transgenesis and gene targeting, will enable in vivo functional analyses of selected candidate genes to identify QTL at the molecular level or to provide insight into mechanisms whereby targeted genes affect pathophysiological traits in the SHR.
authors.affiliation: Department of Genetics of Model Diseases, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic. pravenec@biomed.cas.cz.
authors.forename: M
authors.initials: M
authors.lastname: Pravenec
authors.forename: V
authors.initials: V
authors.lastname: Křen
authors.forename: V
authors.initials: V
authors.lastname: Landa
authors.forename: P
authors.initials: P
authors.lastname: Mlejnek
authors.forename: A
authors.initials: A
authors.lastname: Musilová
authors.forename: J
authors.initials: J
authors.lastname: Šilhavý
authors.forename: M
authors.initials: M
authors.lastname: Šimáková
authors.forename: V
authors.initials: V
authors.lastname: Zídek
mesh_terms: D000818:Animals; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D024821:Metabolic Syndrome / Q000145:classification / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics*; D051381:Rats; D011918:Rats, Inbred SHR / Q000145:classification / Q000235:genetics*; D055647:Rats, Transgenic / Q000235:genetics*; D013045:Species Specificity