title: Possible roles of insulin, IGF-1 and IGFBPs in initiation and progression of colorectal cancer.
abstract: OBJECTIVE
  To investigate the roles of serum insulin, insulin-like growth factor-1 (IGF-1), and insulin-like growth factor binding proteins (IGFBPs) in the initiation and progression of colorectal cancer.
  
  
  METHODS
  We determined serum insulin, IGF-1 and IGFBPs levels in 615 colorectal cancer patients and 650 control healthy donors by enzyme-linked immunosorbent assay (ELISA). In the meantime, their body mass index (BMI) and waist-to-hip ratio (WHR) were measured.
  
  
  RESULTS
  Serum levels of insulin and IGF-1 as well as IGF-1/IGFBP-3 ratio in pre-operation patients were significantly elevated, but the level of IGFBP-3 was significantly decreased compared with normal controls and post-operation patients (P < 0.05 and P < 0.001, respectively). There is no significant difference (P > 0.05) in the levels of insulin, IGF-1, IGFBP-1, IGFBP-3 and IGF-1/IGFBP-3 between the patients with and without hepatic as well as distal abdominal metastases. WHR and BMI of colon cancer patients were positively and significantly correlated with the levels of insulin and IGF-1/IGFBP-3. In contrast, WHR and BMI were negatively correlated with IGFBP-3 level.
  
  
  CONCLUSIONS
  The elevation of insulin, IGF-1 as well as IGF-1/IGFBP-3 ratio and the reduction of IGFBP-3 may be related to the initiation of colorectal cancer, but they are not related to the progression and outcome of the disease.
authors.affiliation: Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Du
authors.affiliation: Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
authors.forename: Dong-Bo
authors.initials: DB
authors.lastname: Liu
authors.affiliation: Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
authors.forename: Cun-Zhi
authors.initials: CZ
authors.lastname: Han
authors.affiliation: Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
authors.forename: Jie-Xian
authors.initials: JX
authors.lastname: Jing
authors.affiliation: Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Zhao
authors.affiliation: Bo Jiang, Xin Zhang, Dong-Bo Liu, Department of Anorectal Surgery, Shanxi Cancer Hospital, Taiyuan 030013, Shanxi Province, China.
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D015179:Colorectal Neoplasms / Q000473:pathology*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D007328:Insulin; D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D020738:Leptin; D007334:Insulin-Like Growth Factor I
keywords: Colorectal cancer; Insulin; Insulin-like growth factor binding protein-3; Insulin-like growth factor-1; Insulin-like growth factor-1/insulin-like growth factor binding protein-3 ratio