title: Study on the interaction between albendazole and eosin Y by fluorescence, resonance Rayleigh scattering and frequency doubling scattering spectra and their analytical applications.
abstract: In pH 3.25-3.35 Britton-Robinson (BR) buffer solution, albendazole (ABZ) could react with eosin Y (EY) to form a 1:1 ion-association complex, which not only results in the quenching of fluorescence, but also resulted in the great enhancement of resonance Rayleigh scattering (RRS) and frequency doubling scattering (FDS). Furthermore, a new RRS spectrum will appear, and the maximum RRS wavelength was located at about 356nm. The detection limit for ABZ were 21.51ng mL(-)(1) for the fluorophotometry, 6.93ng mL(-)(1) for the RRS method and 12.89ng mL(-)(1) for the FDS method. Among them, the RRS method had the highest sensitivity. The experimental conditions were optimized and effects of coexisting substances were evaluated. Meanwhile, the influences of coexisting substances were tested. The methods have been successfully applied to the determination of ABZ in capsules and human urine samples. The composition and structure of the ion-association complex and the reaction mechanism were discussed.
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Chongqing, Beibei 400715, China.
authors.forename: Fengling
authors.initials: F
authors.lastname: Tian
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Chongqing, Beibei 400715, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Chongqing, Beibei 400715, China; School of Chemistry and Environmental Engineering, Chongqing Three Gorges University, Chongqing, Wanzhou 404000, China. Electronic address: flyjd6400@163.com.
authors.forename: Jidong
authors.initials: J
authors.lastname: Yang
authors.affiliation: ChongQing Medical and Health School, Chongqing, Fuling 408100, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
mesh_terms: D015766:Albendazole / Q000032:analysis* / Q000652:urine*; D000977:Antiparasitic Agents / Q000032:analysis* / Q000652:urine*; D004801:Eosine Yellowish-(YS) / Q000737:chemistry*; D005453:Fluorescence; D006801:Humans; D008027:Light; D057230:Limit of Detection; D008958:Models, Molecular; D012542:Scattering, Radiation; D013050:Spectrometry, Fluorescence / Q000379:methods
chemical_list: D000977:Antiparasitic Agents; D015766:Albendazole; D004801:Eosine Yellowish-(YS)
keywords: Albendazole; Eosin Y; Fluorescence quenching; Frequency doubling scattering; Resonance Rayleigh scattering