title: Acetylcholine-triggered cargo release from supramolecular nanovalves based on different macrocyclic receptors.
abstract: Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene- or pillarene-based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled by varying the concentration of ACh in solution or changing the type of gating macrocycle. Although this proof-of-concept study is far from a real-life application, it provides a possible route to treat diseases related to the central nervous system.
authors.affiliation: State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun 130012 (P.R. China).
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhou
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Tan
authors.forename: Qing-Lan
authors.initials: QL
authors.lastname: Li
authors.forename: Xi-Long
authors.initials: XL
authors.lastname: Qiu
authors.forename: Ai-Di
authors.initials: AD
authors.lastname: Qi
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Tao
authors.forename: Ying-Wei
authors.initials: YW
authors.lastname: Yang
mesh_terms: D000109:Acetylcholine / Q000737:chemistry* / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000737:chemistry*; D047250:Calixarenes / Q000737:chemistry*; D002490:Central Nervous System / Q000737:chemistry* / Q000187:drug effects*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D047028:Macrocyclic Compounds; D047250:Calixarenes; D000109:Acetylcholine
keywords: acetylcholine; drug delivery; macrocyclic chemistry; mesoporous materials; silica nanoparticles