title: Dual-histidine kinases in basidiomycete fungi.
abstract: Dual-histidine kinases (HKs) are complex hybrid HKs containing in a single polypeptide two HK transmitter modules (T) and two-response regulator received domains (R) that are combined in a TRTR geometry. In fungi, this protein family is limited to some particular species of the phylum Basidiomycota and absent in the other phyla. This study extends the investigation of dual-HKs to 80 fully sequenced genomes of basidiomycetes, analyzing their distribution, domain architecture and phylogenetic relationships. Moreover, similarly to dual-HKs of basidiomycetes, several species of bacteria were found that contain hybrid HKs with a TRTR domain architecture encoded in a single gene.
authors.affiliation: Genome Analysis Platform, Functional Genomics Unit, CIC bioGUNE, Bizkaia Technology Park, Building 502, 48160 Derio, Spain.
authors.forename: José L
authors.initials: JL
authors.lastname: Lavín
authors.affiliation: Genetics and Microbiology Research Group, Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Sarasola-Puente
authors.affiliation: Genetics and Microbiology Research Group, Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Ramírez
authors.affiliation: Genetics and Microbiology Research Group, Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.
authors.forename: Antonio G
authors.initials: AG
authors.lastname: Pisabarro
authors.affiliation: Genetics and Microbiology Research Group, Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain. Electronic address: jose.oguiza@unavarra.es.
authors.forename: José A
authors.initials: JA
authors.lastname: Oguiza
mesh_terms: D001487:Basidiomycota / Q000201:enzymology* / Q000235:genetics; D005800:Genes, Fungal; D016681:Genome, Fungal; D000071677:Histidine Kinase; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D020543:Proteome; D015398:Signal Transduction / Q000502:physiology
chemical_list: D020543:Proteome; D011494:Protein Kinases; D000071677:Histidine Kinase
keywords: Basidiomycetes; Comparative genomics; Genomic analysis; Histidine kinase; Signal transduction; Two-component system