title: Vicinal difunctionalization of alkenes: chlorotrifluoromethylation with CF3SO2Cl by photoredox catalysis.
abstract: Photoredox-catalyzed vicinal chlorotrifluoromethylation of alkene is described. In the presence of Ru(Phen)3Cl2, CF3SO2Cl was used as a source for the CF3 radical and chloride ion under visible light irradiation. Various terminal and internal alkenes were transformed to their vicinal chlorotrifluoromethylated derivatives. Biologically active compounds were applied under the condition to obtain desired products, suggesting that the method could be feasible for late-stage modification in drug discovery.
authors.affiliation: Division of Drug Discovery Research, Korea Research Institute of Chemical Technology , P.O. Box 107, Yuseong, Daejeon 305-600, Republic of Korea.
authors.forename: Se Hwan
authors.initials: SH
authors.lastname: Oh
authors.forename: Yashwardhan R
authors.initials: YR
authors.lastname: Malpani
authors.forename: Neul
authors.initials: N
authors.lastname: Ha
authors.forename: Young-Sik
authors.initials: YS
authors.lastname: Jung
authors.forename: Soo Bong
authors.initials: SB
authors.lastname: Han
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D008027:Light; D015394:Molecular Structure; D055668:Photochemical Processes
chemical_list: D000475:Alkenes; D006846:Hydrocarbons, Halogenated