title: Aniline-terminated DNA catalyzes rapid DNA-hydrazone formation at physiological pH.
abstract: We report the effect of DNA-templation on aniline-catalyzed N-acylhydrazone formation. The reaction occurs in both two-component and three-component systems. Through systematic catalyst modifications, we are able to increase the efficiency of the DNA-templated variant to 85-fold above that of the uncatalyzed reaction at physiological pH.
authors.affiliation: Department of Chemical and Biological Engineering, University of Colorado Boulder, CO 80303, USA. Dylan.Domaille@colorado.edu Jennifer.Cha@colorado.edu.
authors.forename: Dylan W
authors.initials: DW
authors.lastname: Domaille
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Cha
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D001547:Benzaldehydes / Q000737:chemistry; D002384:Catalysis; D004247:DNA / Q000737:chemistry*; D006835:Hydrazones / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009693:Nucleic Acid Hybridization
chemical_list: D000814:Aniline Compounds; D001547:Benzaldehydes; D006835:Hydrazones; C029915:4-nitrobenzaldehyde; D004247:DNA; C023650:aniline