title: Ultrasound-directed, site-specific gene delivery.
abstract: With the implementation of gene therapy looming in the near term, an effective delivery system using noninvasive, nonviral-mediated methods appears as an attractive option. This novel platform technology uses gas-filled, ultrasound-directed acoustic microspheres for both diagnostic imaging and therapy and yet may provide a key component for future success in the pursuit of single-gene replacement therapy.
authors.affiliation: GE Global Research Niskayuna, Schenectady, NY, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Castle
authors.forename: Steven B
authors.initials: SB
authors.lastname: Feinstein
mesh_terms: D000818:Animals; D016632:Apolipoprotein A-I / Q000235:genetics* / Q000378:metabolism; D003287:Contrast Media; D004195:Disease Models, Animal; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D052456:Hypoalphalipoproteinemias / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D007275:Injections, Intravenous; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D045423:Microbubbles; D008863:Microspheres; D010957:Plasmids / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014465:Ultrasonics
chemical_list: D016632:Apolipoprotein A-I; D003287:Contrast Media; D008075:Lipoproteins, HDL