title: Measurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes.
abstract: We present a system capable of measuring the total retinal blood flow using a combination of dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes and a fundus camera-based retinal vessel analyzer. Our results show a high degree of conformity of venous and arterial flows, which corroborates the validity of the measurements. In accordance with Murray's law, the log-log regression coefficient between vessel diameter and blood flow was found to be ~3. The blood's velocity scaled linearly with the vessel diameter at higher diameters (> 60 µm), but showed a clear divergence from the linear dependence at lower diameters. Good agreement with literature data and the large range and high measurement sensitivity point to a high potential for further investigations.
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Institute of Applied Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040 Vienna, Austria.
authors.forename: Veronika
authors.initials: V
authors.lastname: Doblhoff-Dier
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria ; Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20/6L, A-1090 Vienna, Austria.
authors.forename: Leopold
authors.initials: L
authors.lastname: Schmetterer
authors.affiliation: Imedos Systems UG, Am Nasstal 4, 07751 Jena, Germany.
authors.forename: Walthard
authors.initials: W
authors.lastname: Vilser
authors.affiliation: Department of Clinical Pharmacology, Medical University of Vienna, Waehringer Guertel 18-20/6L, A-1090 Vienna, Austria.
authors.forename: Gerhard
authors.initials: G
authors.lastname: Garhöfer
authors.affiliation: Institute of Applied Physics, Vienna University of Technology, Wiedner Hauptstr. 8-10, 1040 Vienna, Austria.
authors.forename: Martin
authors.initials: M
authors.lastname: Gröschl
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria.
authors.forename: Rainer A
authors.initials: RA
authors.lastname: Leitgeb
authors.affiliation: Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20/4L, A-1090 Vienna, Austria.
authors.forename: René M
authors.initials: RM
authors.lastname: Werkmeister
keywords: (170.0110) Imaging systems; (170.2655) Functional monitoring and imaging; (170.4460) Ophthalmic optics and devices; (170.4500) Optical coherence tomography; (280.2490) Flow diagnostics