title: Sox11 promotes endogenous neurogenesis and locomotor recovery in mice spinal cord injury.
abstract: We introduced a lentiviral vector containing the Sox11 gene into injured spinal cords of mice to evaluate the therapeutic potential of Sox11 in spinal cord injury. Sox11 markedly improved locomotor recovery after spinal cord injury and this recovery was accompanied by an up-regulation of Nestin/Doublecortin expression in the injured spinal cord. Sox11 was mainly located in endogenous neural stem cells lining the central canal and in newly-generated neurons in the spinal cord. In addition, Sox 11 significantly induced expressions of BDNF in the spinal cords of LV-Sox11-treated mice. We concluded that Sox11 induced activation of endogenous neural stem cells into neuronal determination and migration within the injured spinal cord. The resultant increase of BDNF at the injured site might form a distinct neurogenic niche which induces a final neuronal differentiation of these neural stem cells. Enhancing Sox11 expression to induce neurogenic differentiation of endogenous neural stem cells after injury may be a promising strategy in restorative therapy after SCI in mammals.
authors.affiliation: Key Laboratory of the Ministry of Education for Experimental Teratology, Department of Histology and Embryology, Shandong University School of Medicine, 44# Wenhua Xi Road, Jinan, Shandong 250012, PR China.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Guo
authors.affiliation: Key Laboratory of the Ministry of Education for Experimental Teratology, Department of Histology and Embryology, Shandong University School of Medicine, 44# Wenhua Xi Road, Jinan, Shandong 250012, PR China.
authors.forename: Shangming
authors.initials: S
authors.lastname: Liu
authors.affiliation: Key Laboratory of the Ministry of Education for Experimental Teratology, Department of Histology and Embryology, Shandong University School of Medicine, 44# Wenhua Xi Road, Jinan, Shandong 250012, PR China.
authors.forename: Xianghong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of the Ministry of Education for Experimental Teratology, Department of Histology and Embryology, Shandong University School of Medicine, 44# Wenhua Xi Road, Jinan, Shandong 250012, PR China.
authors.forename: Liyan
authors.initials: L
authors.lastname: Wang
authors.affiliation: Key Laboratory of the Ministry of Education for Experimental Teratology, Department of Histology and Embryology, Shandong University School of Medicine, 44# Wenhua Xi Road, Jinan, Shandong 250012, PR China.
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Key Laboratory of the Ministry of Education for Experimental Teratology, Department of Histology and Embryology, Shandong University School of Medicine, 44# Wenhua Xi Road, Jinan, Shandong 250012, PR China.
authors.forename: Aijun
authors.initials: A
authors.lastname: Hao
authors.affiliation: Department of Obstetrics, Maternal and Children Health Hospital of Jinan City, 2# Jingsan Road, Jinan, Shandong 250001, PR China. Electronic address: haq6888@163.com.
authors.forename: Aiqing
authors.initials: A
authors.lastname: Han
authors.affiliation: Department of Pediatrics, Qilu Hospital of Shandong University, 107# Wenhua Xi Road, Jinan, Shandong 250012, PR China. Electronic address: yangjieqilu@gmail.com.
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics; D005260:Female; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000235:genetics / Q000627:therapeutic use*; D016086:Lentivirus / Q000235:genetics; D008124:Locomotion; D051379:Mice; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D055495:Neurogenesis; D055751:SOXC Transcription Factors / Q000032:analysis / Q000235:genetics*; D013116:Spinal Cord / Q000166:cytology* / Q000378:metabolism / Q000503:physiopathology; D013119:Spinal Cord Injuries / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy*; D058630:Spinal Cord Regeneration; D015854:Up-Regulation
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D055751:SOXC Transcription Factors; C490793:Sox11 protein, mouse
keywords: BDNF; Neural stem cell; Neurogenesis; Sox11; Spinal cord injury