title: Limiting progressive hippocampal metabolic abnormalities after smoke inhalation injury.
abstract: A 46-year-old man had a smoke inhalation injury. Within 1 month, he developed neuropsychiatric problems including toxic encephalopathy, cognitive disorder, depression symptoms and personality change. From 3 to 14 years after the toxic inhalation injury, the patient received treatment with sertraline and methylphenidate. The (18)F-fluorodeoxyglucose positron emission tomography scan at 3 years after injury showed deterioration of glucose metabolism in the hippocampus and orbital frontal region; at 14 years after injury, the hippocampus had no significant change but the orbital frontal region had deterioration of glucose metabolism. It was hypothesised that sertraline may have provided selective hippocampal neuroprotection. Further study is justified to evaluate sertraline as a possible neuroprotective agent after smoke inhalation injury.
authors.affiliation: Department of Psychiatry, Cooper Medical School of Rowan University, Marlton, New Jersey, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Tobe
authors.forename: Basant K
authors.initials: BK
authors.lastname: Pradhan
mesh_terms: D001928:Brain Diseases, Metabolic / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D018450:Disease Progression; D005947:Glucose / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D017397:Prefrontal Cortex / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*; D015208:Smoke Inhalation Injury / Q000150:complications* / Q000378:metabolism
chemical_list: D005947:Glucose; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline