title: New cassane-type diterpenoids of Caesalpinia echinata (Leguminosae) exhibiting NF-κB inhibitory activities.
abstract: Seven new cassane-type diterpenoids, echinalides A-G (1-7), were isolated from the stem of Caesalpinia echinata LAM. (Leguminosae). The structures were established on the basis of their chemical properties and spectroscopic evidence, including two dimensional (2D)-NMR analysis. These compounds were assessed for inhibitory activity against nuclear factor κB (NF-κB). Echinalides C and D, in particular, significantly inhibited NF-κB-responsive reporter gene expression at 5.0 µM, an effect almost equivalent to that of parthenolide, a known potent inhibitor of NF-κB.
authors.affiliation: Department of Biological Chemistry, Faculty of Science, Okayama University of Science.
authors.forename: Taichi
authors.initials: T
authors.lastname: Mitsui
authors.forename: Risa
authors.initials: R
authors.lastname: Ishihara
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Hayashi
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Sunadome
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Matsuura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nozaki
mesh_terms: D029911:Caesalpinia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D017930:Genes, Reporter / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D012717:Sesquiterpenes / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D004224:Diterpenes; D016328:NF-kappa B; D010936:Plant Extracts; D012717:Sesquiterpenes; C002669:parthenolide