title: Effect of thyroid dysfunctions on blood cell count and red blood cell indice.
abstract: BACKGROUND
  Thyroid hormones have a crucial role in metabolism and proliferation of blood cells. Thyroid dysfunction induces different effects on blood cells such as anemia, erythrocytosis leukopenia, thrombocytopenia, and in rare cases causes' pancytopenia. It also alter RBC indices include MCV, MCH, MCHC and RDW. Thus this study attempted to evaluate effect of hypo & hyperthyroidism on blood cell count and RBC indices.
  
  
  METHODS
  This study performed on 102 patients with hypothyroid (14.1 years), 84 with hyperthyroid (15.6 years) and 118 healthy individuals (15.2 years) as control group. Initially patients TSH level of patients was determined by ELISA method, and then according to TSH ranges (0.3-5.5µIU/mL) patients were divided into two Hyperthyroidism (TSH<0.3µIU/mL) and hypothyroidism (TSH>5.5µIU/mL) groups. Then, complete blood count was measured by cell counter. Finally, obtained results were analyzed by SPSS software.
  
  
  RESULTS
  Analyzes of obtained data revealed statistically significant difference between two groups of patients in RBC count, MCH, MCHC, RDW, HB and HCT(P-value<0.05), but the difference was not significant for WBC and PLT counts and MCV (P-value>0.05).
  
  
  CONCLUSIONS
  In case of patients with unknown hematological dysfunctions, must be evaluated for thyroid hormones.
authors.affiliation: Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Dorgalaleh
authors.affiliation: Pars pathobiology laboratory, Minoodasht, Golestan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Mahmoodi
authors.affiliation: Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: B
authors.initials: B
authors.lastname: Varmaghani
authors.affiliation: Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Kiani Node
authors.affiliation: Medical Laboratory Sciences Department Allied Medical School, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: O
authors.initials: O
authors.lastname: Saeeidi Kia
authors.affiliation: Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Alizadeh
authors.affiliation: Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Sh
authors.initials: Sh
authors.lastname: Tabibian
authors.affiliation: Parasitology Department Allied Medical School, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: T
authors.initials: T
authors.lastname: Bamedi
authors.affiliation: Imam Ali hospital, Sistan and Baluchistan, Chahbahar, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Momeni
authors.affiliation: Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Abbasian
authors.affiliation: Hematology Department Allied Medical School, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Kashani Khatib
keywords: Hyperthyroidism; Hypothyroidism; TSH