title: Interleukin-6 in inflammatory and malignant diseases of the pancreas.
abstract: Interleukin-6 is an important pro-inflammatory cytokine strongly linked to the most burdened exocrine pancreatic diseases including acute pancreatitis, chronic pancreatitis and pancreatic cancer. However, its role in all these diseases is versatile and not completely defined. Several studies provided accumulating evidence that IL-6 is mainly involved in the JAK/STAT pathway activation promoting acute and chronic pancreatitis disease aggravation as well as pancreatic cancer initiation and progression. This review will focus on recent studies illustrating the role of IL-6 in acute and chronic pancreatitis and pancreatic oncogenesis. Further, a short overview of indicated disease pathologies will be given and the impact of IL-6 in JAK/STAT pathway, persistent STAT3 activation and cancer immunotherapy will be discussed.
authors.affiliation: II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaniger Strasse 22, Munich 81675, Germany.
authors.forename: Marina
authors.initials: M
authors.lastname: Lesina
authors.affiliation: II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaniger Strasse 22, Munich 81675, Germany.
authors.forename: Sonja Maria
authors.initials: SM
authors.lastname: Wörmann
authors.affiliation: II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaniger Strasse 22, Munich 81675, Germany.
authors.forename: Patrick
authors.initials: P
authors.lastname: Neuhöfer
authors.affiliation: II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaniger Strasse 22, Munich 81675, Germany.
authors.forename: Liang
authors.initials: L
authors.lastname: Song
authors.affiliation: II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, Ismaniger Strasse 22, Munich 81675, Germany. Electronic address: hana.alguel@lrz.tum.de.
authors.forename: Hana
authors.initials: H
authors.lastname: Algül
mesh_terms: D000818:Animals; D018450:Disease Progression; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism*; D058990:Molecular Targeted Therapy; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D010195:Pancreatitis / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism*; D050796:STAT3 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D059016:Tumor Microenvironment / Q000235:genetics
chemical_list: D015850:Interleukin-6; D050796:STAT3 Transcription Factor
keywords: Acute pancreatitis; Chronic pancreatitis; IL-6 signaling; IL-6 trans-signaling; Pancreatic cancer; STAT3