title: [Clinical trial on the prevention of diarrhea by oral BIFICO for infants aged 1-6 years].
abstract: OBJECTIVE
  To investigate the prevention of diarrhea by oral BIFICO for infants aged 1-6 years.
  
  
  METHODS
  490 cases of infants were randomly divided after age stratification: the experimental group (n = 247) and the control group (n = 243). Based on principles of randomized double-blind and placebo-controlled, the infants were given BIFICO (dedicated clinical research)therapy for 4 consecutive days, then observed for 21 days. 25 days composed a cycle. They were observed total 5 cycles. During the study period, principles for "the diarrhoea patients must be detected", follow-up visited the participant infants and conducted etiology detection by way of sampling for diarrhea infants. Evaluate the prevention efficacy of diarrhea by oral BIFICO for infants aged 1-6 years.
  
  
  RESULTS
  A total of 480 completed all study. 120 and 95 infants in the control group and experimental group were detected with diarrhea. The incidence of diarrhea was 50.85% and 38.93% in these two guoup, respectively. The difference has statistical significance (chi2 = 4.175, P = 0.041). In the third observation period, the infants in the control group had a higer incidence of diarrhea compared with which in the experimental group (chi2 = 4.415, P = 0.036). 14 strains of rotavirus, 3 strains of norovirus, 3 strains of sappovirus, 2 strains of adenovirus, 5 strains of salmonella and 4 strains of Shigella were check out in 128 samples.
  
  
  CONCLUSIONS
  Oral BIFICO can paly certain preventive role on diarrhea, and decrease the incidence of diarrhea in infants aged 1-6 years.
authors.affiliation: Department of Community Health, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014, China.
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Liu
authors.affiliation: Department of Community Health, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014, China.
authors.forename: Meng-Lei
authors.initials: ML
authors.lastname: Li
authors.affiliation: Department of Community Health, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014, China.
authors.forename: Wen-Xia
authors.initials: WX
authors.lastname: Ma
authors.affiliation: Department of Community Health, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014, China.
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Xia
authors.affiliation: Department of Community Health, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014, China.
authors.forename: Bian-Li
authors.initials: BL
authors.lastname: Xu
mesh_terms: D000284:Administration, Oral; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000188:drug therapy / Q000517:prevention & control*; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D019936:Probiotics / Q000008:administration & dosage*