title: Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase.
abstract: An efficient and sustainable biocatalytic route for the synthesis of important 17-α-amino steroids has been developed using an ω-transaminase variant from Arthrobacter sp. Optimisation of the reaction conditions facilitated the synthesis of these valuable synthons on a preparative scale, affording excellent isolated yields and stereocontrol.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK. h.c.hailes@ucl.ac.uk.
authors.forename: Nina
authors.initials: N
authors.lastname: Richter
authors.forename: Robert C
authors.initials: RC
authors.lastname: Simon
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kroutil
authors.forename: John M
authors.initials: JM
authors.lastname: Ward
authors.forename: Helen C
authors.initials: HC
authors.lastname: Hailes
mesh_terms: D001173:Arthrobacter / Q000201:enzymology*; D055162:Biocatalysis; D015394:Molecular Structure; D013237:Stereoisomerism; D013256:Steroids / Q000096:biosynthesis* / Q000737:chemistry*; D000637:Transaminases / Q000378:metabolism*
chemical_list: D013256:Steroids; D000637:Transaminases