title: Factors affecting the ability of baclofen to reduce fat intake in rats.
abstract: The GABA-B agonist baclofen has been reported to reduce the consumption of vegetable shortening, but not lard, in rats. This study sought to examine some of the factors that could account for these differences. Baclofen (0, 1.0, 1.8, 3.2 mg/kg, intraperitoneal) was tested: (i) on shortening and lard intake, (ii) under 'binge-type' and non-'binge-type' conditions, (iii) when each fat was presented alone or simultaneously, and (iv) with a 30-min or no pretreatment time. With a 30-min pretreatment time, baclofen (3.2 mg/kg, intraperitoneal) consistently reduced shortening intake under 'binge-type' and non-'binge-type' conditions, as well as when shortening was presented alone or when lard was simultaneously available. Baclofen also reduced lard intake under 'binge-type' and non-'binge-type' conditions, but only when lard was presented alone. Baclofen had no effect on chow intake. When each fat was presented alone, and with no pretreatment time, the results were less consistent; baclofen reduced shortening intake only under non-'binge-type' conditions, and lard intake only under 'binge-type' conditions, and also stimulated chow intake. In summary, the type of fat, the presentation mode (one fat presented alone or two fats simultaneously), and the time between baclofen administration and intake all influence the ability of baclofen to reduce fat intake.
authors.affiliation: aDepartment of Nutritional Sciences, College of Health and Human Development bDepartment of Kinesiology, Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Francis H E
authors.initials: FH
authors.lastname: Wojnicki
authors.forename: Shane D
authors.initials: SD
authors.lastname: Brown
authors.forename: Rebecca L W
authors.initials: RL
authors.lastname: Corwin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects*; D001418:Baclofen / Q000494:pharmacology*; D001835:Body Weight; D002032:Bulimia / Q000188:drug therapy; D004041:Dietary Fats / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005518:Food Preferences; D058786:GABA-B Receptor Agonists / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D004041:Dietary Fats; D058786:GABA-B Receptor Agonists; D001418:Baclofen; C029310:lard