title: Lipoic acid decreases peritoneal adhesion formation in a rat uterine scar model.
abstract: OBJECTIVE
  To investigate the effects of lipoic acid in the prevention of postoperative pelvic adhesions by a visual scoring system and immunohistochemistry in a rat uterine horn model with full thickness injury.
  
  
  METHODS
  Twenty-eight female Wistar albino rats were randomised into four groups: uterine trauma control, 15 days and 30 days, and uterine trauma + lipoic acid, 15 days and 30 days. A full thickness defect was established by incising a segment of approximately 1.0 cm in length from each uterine horn, leaving the mesometrium intact. Extension and severity of the adhesions in each group were scored by a visual scoring system and evaluated immunohistochemically.
  
  
  RESULTS
  Adhesion scores were 2.00±0.81, 2.14±0.69 0.71±0.75, and 0.85±0.69 for extent and 2.28±0.48, 2.14±0.69, 0.85±0.69, and 1.14±0.69 for severity in Groups 1, 2, 3 and 4, respectively. Adhesion extent and severity were significantly less for groups treated by lipoic acid but no difference was observed between long and short administration. Both Vitronectin and u-PAR staining were significantly increased in treatment groups when compared to the control group.
  
  
  CONCLUSIONS
  Lipoic acid was found to be effective in reducing postoperative adhesion formation in a rat model.
authors.affiliation: Department of Histology and Embryology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
authors.forename: Serap Cilaker
authors.initials: SC
authors.lastname: Mıcılı
authors.affiliation: Department of Obstetrics and Gynecology, Celal Bayar University Faculty of Medicine, Manisa, Turkey.
authors.forename: Aslı
authors.initials: A
authors.lastname: Göker
authors.affiliation: Department of Biochemistry, Dokuz Eylül University Learning Resources Center, İzmir, Turkey.
authors.forename: Oya
authors.initials: O
authors.lastname: Sayın
authors.affiliation: Department of Histology and Embryology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Akokay
authors.affiliation: Department of Histology and Embryology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.
authors.forename: Bekir Uğur
authors.initials: BU
authors.lastname: Ergür
keywords: Lipoic acid; adhesion; full thickness uterine injury; rat; uterine scar