title: Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7.
abstract: The endogenous ligands for the LT, lipoxin (LX) and oxoeicosanoid receptors are bioactive products produced by the action of the lipoxygenase family of enzymes. The LT receptors BLT1 and BLT2 , are activated by LTB4 and the CysLT1 and CysLT2 receptors are activated by the cysteinyl-LTs, whereas oxoeicosanoids exert their action through the OXE receptor. In contrast to these pro-inflammatory mediators, LXA4 transduces responses associated with the resolution of inflammation through the receptor FPR2/ALX (ALX/FPR2). The aim of the present review is to give a state of the field on these receptors, with focus on recent important findings. For example, BLT1 receptor signalling in cancer and the dual role of the BLT2 receptor in pro- and anti-inflammatory actions have added more complexity to lipid mediator signalling. Furthermore, a cross-talk between the CysLT and P2Y receptor systems has been described, and also the presence of novel receptors for cysteinyl-LTs, such as GPR17 and GPR99. Finally, lipoxygenase metabolites derived from ω-3 essential polyunsaturated acids, the resolvins, activate the receptors GPR32 and ChemR23. In conclusion, the receptors for the lipoxygenase products make up a sophisticated and tightly controlled system of endogenous pro- and anti-inflammatory signalling in physiology and pathology.
authors.affiliation: Nomenclature Subcommittee for Leukotriene Receptors, International Union of Basic and Clinical Pharmacology, Stockholm, Sweden; Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Magnus
authors.initials: M
authors.lastname: Bäck
authors.forename: William S
authors.initials: WS
authors.lastname: Powell
authors.forename: Sven-Erik
authors.initials: SE
authors.lastname: Dahlén
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Drazen
authors.forename: Jilly F
authors.initials: JF
authors.lastname: Evans
authors.forename: Charles N
authors.initials: CN
authors.lastname: Serhan
authors.forename: Takao
authors.initials: T
authors.lastname: Shimizu
authors.forename: Takehiko
authors.initials: T
authors.lastname: Yokomizo
authors.forename: G Enrico
authors.initials: GE
authors.lastname: Rovati
mesh_terms: D000818:Animals; D006801:Humans; D008024:Ligands; D018055:Receptors, Eicosanoid / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008024:Ligands; D018055:Receptors, Eicosanoid
keywords: LTs; cancer; cardiovascular; eicosanoids; inflammation; lipoxins; lipoxygenase; oxoeicosanoids; respiratory