title: Hypoxia-inducible factor-1α C1772T polymorphism and cancer risk: a meta-analysis including 18,334 subjects.
abstract: Studies on HIF 1α C1772T (P582S) polymorphism revealed a genetic susceptibility to malignant tumors, however, the results were conflicting. We conducted a meta-analysis utilizing 29 eligible case-control studies to analyze the data concerning the association between the HIF-1α C1772T polymorphism and cancer risks. There was statistical association between the HIF-1α CT/TT genotype and cancer risk (OR = 1.28, 95% CI = 1.06-1.54, P(heterogeneity) < .00001). The stability of these observations was confirmed by a one-way sensitivity analysis. Our findings suggested that CT/TT genotype was associated with increased risks of prostate cancer. Besides, the HIF-1α C1772T polymorphism most likely contributes to susceptibility to malignant tumors, especially in American population.
authors.affiliation: 1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Ye
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Shuang
authors.initials: S
authors.lastname: Hu
authors.forename: Yingqiang
authors.initials: Y
authors.lastname: Shi
authors.forename: Xiefu
authors.initials: X
authors.lastname: Zhang
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhou
authors.forename: Chunlin
authors.initials: C
authors.lastname: Zhao
authors.forename: Guojun
authors.initials: G
authors.lastname: Wang
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wen
authors.forename: Hong
authors.initials: H
authors.lastname: Zong
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit