title: Adiponectin and bariatric surgery: associations with diabetes and cardiovascular disease in the Swedish Obese Subjects Study.
abstract: OBJECTIVE
  Adiponectin has been implicated in the pathogenesis of type 2 diabetes, but its role for incident diabetes, myocardial infarction, or stroke in obesity is unclear. The aim of this study was to analyze the associations between systemic levels of adiponectin and the aforementioned outcomes in a population with severe obesity at high risk of diabetes and cardiovascular events.
  
  
  METHODS
  We measured serum concentrations of total adiponectin in 3,299 participants of the prospective controlled Swedish Obese Subjects (SOS) Study (bariatric surgery group, n = 1,570; control group given usual care, n = 1,729). Median follow-up periods ranged between 10 and 13 years for different outcomes.
  
  
  RESULTS
  In models containing both baseline adiponectin and 2-year changes in adiponectin, high baseline adiponectin and 2-year increases in adiponectin were associated with decreased risk of diabetes and myocardial infarction among controls. In the surgery group, the 2-year weight loss was paralleled by substantial increase in circulating adiponectin (1,807-1,958 ng/mL per 10-kg weight loss). However, neither baseline adiponectin nor 2-year increases in adiponectin were associated with risk of diabetes or myocardial infarction in the fully adjusted models in the surgery group. No associations were found for stroke in either group.
  
  
  CONCLUSIONS
  Taken together, baseline adiponectin and 2-year changes were associated with incident diabetes and myocardial infarction in the control group but not in the surgery group. Baseline adiponectin did not predict treatment benefit of bariatric surgery.
authors.affiliation: Corresponding author: Christian Herder, christian.herder@ddz.uni-duesseldorf.de.
authors.forename: Christian
authors.initials: C
authors.lastname: Herder
authors.forename: Markku
authors.initials: M
authors.lastname: Peltonen
authors.forename: Per-Arne
authors.initials: PA
authors.lastname: Svensson
authors.forename: Maren
authors.initials: M
authors.lastname: Carstensen
authors.forename: Peter
authors.initials: P
authors.lastname: Jacobson
authors.forename: Michael
authors.initials: M
authors.lastname: Roden
authors.forename: Lars
authors.initials: L
authors.lastname: Sjöström
authors.forename: Lena
authors.initials: L
authors.lastname: Carlsson
mesh_terms: D052242:Adiponectin / Q000097:blood*; D050110:Bariatric Surgery; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology; D009767:Obesity, Morbid / Q000097:blood / Q000453:epidemiology* / Q000601:surgery*; D011446:Prospective Studies; D020521:Stroke / Q000097:blood / Q000453:epidemiology*; D015431:Weight Loss
chemical_list: D052242:Adiponectin