title: Influence of Rho kinase inhibitor Fasudil on late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.
abstract: The objective of our work was to investigate the influence of Fasudil, a Rho inhibitor on the number and function of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary artery hypertension. Eighty COPD patients with pulmonary artery hypertension were selected and divided into two groups: the treatment group and the control group, which had 40 patients respectively. The control group received routine treatment, including oxygen uptake, anti-infection and phlegm dissolving. The treatment group received the Fasudil in addition to the routine treatment. The changes on the number and function of the late endothelial progenitor cells in peripheral blood of the patients before and after the treatment were compared between the two groups. The changes on the pulmonary artery pressure were also compared. The number of the late endothelial progenitor cells in peripheral blood of the treatment group increased and the function was enhanced. The pulmonary artery pressure was reduced. The difference before and after the treatment and with the control group was statistically significant (p<0.05). The changes on the number and function of the late endothelial progenitor cells in peripheral blood and the pulmonary artery pressure before and after the treatment of the control group were not statistically significant (p>0.05). The Rho-kinase inhibitor Fasudil increased the number and enhanced the function of the late endothelial progenitor cells in peripheral blood of COPD patients with pulmonary artery hypertension.
authors.affiliation: Intense Care Unit, Taihe Hospital of Hubei Medical University, 32 Renmin Road, Hubei, 442000, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Liu
authors.affiliation: Department of Respiratoy Diseases,Taihe Hospital of Hubei Medical University, 32 Renmin Road Hubei, 442000, China.
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Respiratoy Diseases,Taihe Hospital of Hubei Medical University, 32 Renmin Road Hubei, 442000, China.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Tang
authors.affiliation: Intense Care Unit, Taihe Hospital of Hubei Medical University, 32 Renmin Road, Hubei, 442000, China.
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Sheng
authors.affiliation: Department of Ultrasound Imaging, Taihe Hospital of Hubei Medical University Shiyan, 32 Renmin Road, Hubei, 442000,China.
authors.forename: Jianxin
authors.initials: J
authors.lastname: Liu
authors.affiliation: Beijing University of Technology, 100 Ping Le Yuan, Chaoyang District, Beijing 100022, China.
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Zeng
mesh_terms: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D002448:Cell Adhesion; D002465:Cell Movement; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000166:cytology*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy*; D013234:Stem Cells / Q000166:cytology*; D054460:rho-Associated Kinases / Q000378:metabolism
chemical_list: D047428:Protein Kinase Inhibitors; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D054460:rho-Associated Kinases; C049347:fasudil; D010100:Oxygen