title: Ionic liquid-modified magnetic polymeric microspheres as dispersive solid phase extraction adsorbent: a separation strategy applied to the screening of sulfamonomethoxine and sulfachloropyrazine from urine.
abstract: Ionic liquid-modified magnetic polymeric microspheres (ILMPM) were prepared based on Fe3O4 magnetic nanoparticles (MNPs) and ionic liquids (ILs) incorporated into a polymer. The composites were characterized using scanning electron microscopy, Fourier transform infrared analysis, thermogravimetric analysis, X-ray diffraction, and vibrating magnetometer, which indicated that ILMPM had a regularly spherical shape and strong magnetic property. The obtained ILMPM were successfully applied as a special adsorbent of magnetic dispersive solid phase extraction (MDSPE) for the rapid extraction and isolation of sulfamonomethoxine sodium and sulfachloropyrazine sodium in urine. The factors that affected extraction efficiency, such as adsorption conditions, desorption conditions, washing and elution solvents, and pH of the sample solution, were optimized. Under the optimum condition, good linearity in the range of 0.005-2.0 μg g(-1) (r ≥ 0.9996) was obtained for the two sulfonamides (SAs); the average recoveries at three spiked levels ranged from 86.9 to 102.1 %, with relative standard deviations of ≤4.3 %. The presented ILMPM-MDSPE method combined the advantages of ILs, MNPs, and MDSPE and therefore could be potentially applied for rapid screening of SAs in urine.
authors.affiliation: Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding, 071002, China, yanhy@hbu.edu.cn.
authors.forename: Hongyuan
authors.initials: H
authors.lastname: Yan
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Gao
authors.forename: Chen
authors.initials: C
authors.lastname: Yang
authors.forename: Mande
authors.initials: M
authors.lastname: Qiu
mesh_terms: D000327:Adsorption; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry; D060328:Magnetic Phenomena; D008863:Microspheres; D011108:Polymers / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000295:instrumentation* / Q000379:methods; D013422:Sulfamonomethoxine / Q000302:isolation & purification* / Q000652:urine; D013424:Sulfanilamides / Q000302:isolation & purification* / Q000652:urine; D000096926:Benzenesulfonamides
chemical_list: D052578:Ionic Liquids; D011108:Polymers; D013422:Sulfamonomethoxine; D013424:Sulfanilamides; C050643:sulfachlorpyrazine; D000096926:Benzenesulfonamides