title: Eudragit L/HPMCAS blend enteric-coated lansoprazole pellets: enhanced drug stability and oral bioavailability.
abstract: The objectives of the present work were to use blends of Eudragit L and hydroxypropyl methylcellulose acetate succinate (HPMCAS) as enteric film coatings for lansoprazole (LSP) pellets. The enteric-coated pellets were prepared with a fluid-bed coater. The influence of the blend ratio, type of plasticizer, plasticizer level, coating level, and curing conditions on gastric stability in vitro drug release and drug stability was evaluated. Furthermore, the bioavailability of the blend-coated pellets in beagle dogs was also performed. The blend-coated pellets exhibited significant improvement of gastric stability and drug stability compared to the pure polymer-coated pellets. Moreover, the AUC values of blend-coated pellets were greater than that of the pure polymer-coated pellets. It was concluded that the using blends of Eudragit L and HPMCAS as enteric film coatings for LSP pellets improved the drug stability and oral bioavailability.
authors.affiliation: Department of Pharmaceutics, School of Pharmaceutical Science, Hebei Medical University, Shijiazhuang, 050017, China, fangyumedu@126.com.
authors.forename: Yu
authors.initials: Y
authors.lastname: Fang
authors.forename: Guozheng
authors.initials: G
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Liu
authors.forename: Zhenghua
authors.initials: Z
authors.lastname: Liu
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wu
authors.forename: Deying
authors.initials: D
authors.lastname: Cao
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004285:Dogs; D004355:Drug Stability; D064747:Lansoprazole / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D010968:Plasticizers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry*; D054328:Proton Pump Inhibitors / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D012995:Solubility; D013608:Tablets, Enteric-Coated; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D010968:Plasticizers; D011109:Polymethacrylic Acids; D054328:Proton Pump Inhibitors; D013608:Tablets, Enteric-Coated; D064747:Lansoprazole; C038300:methylmethacrylate-methacrylic acid copolymer; C048331:hydroxypropylmethylcellulose acetate succinate; D008747:Methylcellulose