title: Analysis of DevR regulated genes in Mycobacterium tuberculosis.
abstract: The DevRS two component system of Mycobacterium tuberculosis is responsible for its dormancy in host and becomes operative under hypoxic condition. It is experimentally known that phosphorylated DevR controls the expression of several downstream genes in a complex manner. In the present work we propose a theoretical model to show role of binding sites in DevR mediated gene expression. Individual and collective role of binding sites in regulating DevR mediated gene expression has been shown via modeling. Objective of the present work is twofold. First, to describe qualitatively the temporal dynamics of wild type genes and their known mutants. Based on these results we propose that DevR controlled gene expression follows a specific pattern which is efficient in describing other DevR mediated gene expression. Second, to analyze behavior of the system from information theoretical point of view. Using the tools of information theory we have calculated molecular efficiency of the system and have shown that it is close to the maximum limit of isothermal efficiency.
authors.affiliation: Department of Chemistry, Bose Institute, 93/1 A P C Road, Kolkata, 700009 India.
authors.forename: Arnab
authors.initials: A
authors.lastname: Bandyopadhyay
authors.affiliation: Department of Chemistry, Bose Institute, 93/1 A P C Road, Kolkata, 700009 India.
authors.forename: Soumi
authors.initials: S
authors.lastname: Biswas
authors.affiliation: Department of Chemistry, University of Calcutta, 92 A P C Road, Kolkata, 700009 India.
authors.forename: Alok Kumar
authors.initials: AK
authors.lastname: Maity
authors.affiliation: Department of Chemistry, Bose Institute, 93/1 A P C Road, Kolkata, 700009 India.
authors.forename: Suman K
authors.initials: SK
authors.lastname: Banik
keywords: Dormancy; Information theory; Mycobacterium tuberculosis; Two component system