title: The application of polymerized porcine hemoglobin (pPolyHb) in the rat small bowel preservation.
abstract: Small bowel transplantation (SBTx) has become a standard clinical treatment for short bowel syndrome or irreversible intestinal function failure. Optimum preservation of the organ is essential for the success of transplantation. In this study, pPolyHb was used as an additive to hypertonic citrate adenine solution (HCA) to provide oxygen for rat small bowel transplant. Rat small bowels were preserved in HCA, HCA with pPolyHb, and University of Wisconsin solution (UW) for 12, 24, and 36 h, respectively. The results suggested that the preservation effect of HCA with pPolyHb was comparable with the UW solution, and more effective than the HCA solution.
authors.affiliation: College of Life Science, Northwest University , Xi'an , P. R. China.
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Wenjin
authors.initials: W
authors.lastname: Zhu
authors.forename: Jinghui
authors.initials: J
authors.lastname: Sun
authors.forename: Kunping
authors.initials: K
authors.lastname: Yan
authors.forename: Bo
authors.initials: B
authors.lastname: Song
authors.forename: Yuejin
authors.initials: Y
authors.lastname: Xue
authors.forename: Jianguo
authors.initials: J
authors.lastname: Xin
authors.forename: Wencan
authors.initials: W
authors.lastname: Pan
authors.forename: Hongli
authors.initials: H
authors.lastname: Zhu
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
mesh_terms: D000225:Adenine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001784:Blood Gas Analysis; D006454:Hemoglobins / Q000737:chemistry*; D007421:Intestine, Small / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011309:Preservation, Biological / Q000379:methods*; D055503:Protein Multimerization; D051381:Rats; D013552:Swine
chemical_list: D006454:Hemoglobins; D000255:Adenosine Triphosphate; D000225:Adenine
keywords: University of Wisconsin solution; cold storage; hypertonic citrate adenine solution; polymerized porcine hemoglobin; small bowel preservation