title: Cannabinoid neuromodulation in the adult early visual cortex.
abstract: Sensory processing is an active process involving the interaction of ongoing cortical activity with incoming stimulus information. However, the modulators and circuits involved in this interaction are incompletely understood. One potential candidate is the cannabinoid-signaling system, which is known to modulate the dynamics of cortical networks. Here, we show that in the primate primary and secondary visual cortices, the cannabinoid CP55940 modulates not only population dynamics but also influences the dynamics of the stimulus-response relationship of individual neurons. At the population level, CP55940 decreases EEG power, LFP power, and LFP coherence. At the single-neuron level, intrinsic spike train dynamics appear relatively unchanged, but visual receptive fields are altered: CP55940 induced an overall delay and broadening of the temporal component of V1 and V2 spatiotemporal receptive fields. Our findings provide neurophysiologic evidence for a link between cannabinoid-signaling, network dynamics and the function of a canonical cortical circuit.
authors.affiliation: Division of Systems Neurology and Neuroscience, Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, United States of America.
authors.forename: Ifije E
authors.initials: IE
authors.lastname: Ohiorhenuan
authors.affiliation: Division of Systems Neurology and Neuroscience, Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, United States of America.
authors.forename: Ferenc
authors.initials: F
authors.lastname: Mechler
authors.affiliation: Division of Systems Neurology and Neuroscience, Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, United States of America.
authors.forename: Keith P
authors.initials: KP
authors.lastname: Purpura
authors.affiliation: Division of Systems Neurology and Neuroscience, Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, United States of America.
authors.forename: Anita M
authors.initials: AM
authors.lastname: Schmid
authors.affiliation: Division of Systems Neurology and Neuroscience, Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, United States of America.
authors.forename: Qin
authors.initials: Q
authors.lastname: Hu
authors.affiliation: Division of Systems Neurology and Neuroscience, Brain and Mind Research Institute, Weill Cornell Medical College, New York, New York, United States of America.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Victor
mesh_terms: D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D003511:Cyclohexanols / Q000494:pharmacology; D055724:Electrophysiological Phenomena / Q000187:drug effects; D008253:Macaca mulatta; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D010775:Photic Stimulation; D014793:Visual Cortex / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
chemical_list: D002186:Cannabinoids; D003511:Cyclohexanols; C054649:3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol