title: A case of pulmonary hemorrhage due to drug-induced pneumonitis secondary to ticagrelor therapy.
abstract: We report a case of significant pulmonary hemorrhage developing shortly after commencing ticagrelor and aspirin therapy and requiring coronary artery bypass grafting to safely cease the antiplatelet therapy. Lung biopsy findings were consistent with drug-induced lung injury. Clinicians should be aware of this significant adverse event with this drug class.
authors.affiliation: Respiratory Medicine Department, Royal Perth Hospital, Perth. Electronic address: timothy.whitmore@health.wa.gov.au.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Whitmore
authors.affiliation: Department of Cardiovascular Medicine, Fremantle Hospital, Fremantle.
authors.forename: John P
authors.initials: JP
authors.lastname: O'Shea
authors.affiliation: Western Diagnostic Pathology, Myaree.
authors.forename: Diana
authors.initials: D
authors.lastname: Starac
authors.affiliation: Department of Cardiothoracic Surgery, Royal Perth Hospital, Perth.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Edwards
authors.affiliation: School of Medicine & Pharmacology, University of Western Australia, Perth, WA, Australia.
authors.forename: Grant W
authors.initials: GW
authors.lastname: Waterer
mesh_terms: D054058:Acute Coronary Syndrome / Q000628:therapy*; D000241:Adenosine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use; D001706:Biopsy; D001026:Coronary Artery Bypass; D003937:Diagnosis, Differential; D006469:Hemoptysis / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000627:therapeutic use; D011014:Pneumonia / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D058921:Purinergic P2Y Receptor Antagonists / Q000009:adverse effects / Q000627:therapeutic use; D000077486:Ticagrelor; D014057:Tomography, X-Ray Computed
chemical_list: D010975:Platelet Aggregation Inhibitors; D058921:Purinergic P2Y Receptor Antagonists; D000077486:Ticagrelor; D000241:Adenosine; D001241:Aspirin