title: Neuropsychological and physiological correlates of fatigue following traumatic brain injury.
abstract: BACKGROUND
  Fatigue is a common and debilitating phenomenon experienced by individuals with traumatic brain injury (TBI) that can negatively influence rate and extent of functional recovery by reducing participation in brain injury rehabilitation services and increasing maladaptive lifestyle practices. The underlying mechanisms of TBI-related fatigue are not entirely understood and focused research on symptom reduction or prevention is limited.
  
  
  METHODS
  The current review of the literature suggests that the aetiology of TBI-related fatigue can be viewed as a multifactorial and complex model impacting physiological systems (i.e. endocrine, skeletal muscle and cardiorespiratory) that can be directly or indirectly influenced by neuropsychological correlates including cognitive and psychological impairment. Distinguishing central from peripheral fatigue is helpful in this regard. Potential therapeutic strategies and pharmacological agents to help alleviate fatigue in this patient population are discussed.
authors.affiliation: Transitional Learning Center , Galveston, TX , USA and.
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Zgaljardic
authors.forename: William J
authors.initials: WJ
authors.lastname: Durham
authors.forename: Kurt A
authors.initials: KA
authors.lastname: Mossberg
authors.forename: Jack
authors.initials: J
authors.lastname: Foreman
authors.forename: Keta
authors.initials: K
authors.lastname: Joshipura
authors.forename: Brent E
authors.initials: BE
authors.lastname: Masel
authors.forename: Randall
authors.initials: R
authors.lastname: Urban
authors.forename: Melinda
authors.initials: M
authors.lastname: Sheffield-Moore
mesh_terms: D000203:Activities of Daily Living; D000222:Adaptation, Physiological; D001930:Brain Injuries / Q000150:complications / Q000503:physiopathology*; D015444:Exercise; D005221:Fatigue / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011379:Prognosis; D011788:Quality of Life; D020127:Recovery of Function; D012039:Regional Blood Flow; D018434:Sickness Impact Profile; D012890:Sleep; D012893:Sleep Wake Disorders / Q000209:etiology / Q000503:physiopathology*