title: Obesity: the 'huge' problem in cardiovascular diseases.
abstract: Obesity is an epidemic in the United States. It is an independent risk factor for cardiovascular diseases and associated with reduced life expectancy. The adverse effects are related to direct impact of obesity on cardiovascular system and indirectly through its influence on risk factors. Excessive accumulation of adipose tissue in the myocardium leads to structural and functional alteration. In addition, numerous hormones secreted by adipose tissue create pro-inflammatory and prothrombotic state. This predisposes to coronary heart disease, heart failure, and sudden death. Even those with normal weight but excessive body fat are at risk. Weight reduction and exercise are the main therapeutic options.
authors.affiliation: Department of Medicine, Cardiology Division at the Truman Medical Center and the University of Missouri-Kansas City School of Medicine, USA. Javed.Ashraf@tmcmed.org
authors.forename: M Javed
authors.initials: MJ
authors.lastname: Ashraf
authors.affiliation: Department of Medicine, Cardiology Division at the Truman Medical Center and the University of Missouri-Kansas City School of Medicine, USA.
authors.forename: Paramdeep
authors.initials: P
authors.lastname: Baweja
mesh_terms: D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D003327:Coronary Disease / Q000150:complications / Q000378:metabolism / Q000628:therapy; D016757:Death, Sudden, Cardiac; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism / Q000628:therapy; D050171:Dyslipidemias / Q000150:complications / Q000378:metabolism / Q000628:therapy; D015444:Exercise; D006333:Heart Failure / Q000150:complications / Q000378:metabolism / Q000628:therapy; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000378:metabolism / Q000628:therapy; D007249:Inflammation / Q000378:metabolism; D009765:Obesity / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D050177:Overweight / Q000150:complications / Q000378:metabolism / Q000628:therapy; D014481:United States; D061217:Weight Reduction Programs
chemical_list: D054392:Adipokines