title: The Glu298Asp polymorphism in the NOS3 gene and the risk of prostate cancer.
abstract: The Glu298Asp polymorphism in the NOS3 gene has been implicated as a risk factor for prostate cancer. To date, several studies have evaluated the associations between the Glu298Asp polymorphism and prostate cancer risk; however, the results were inconclusive. The aim of the current study was to perform a meta-analysis to investigate the association between the polymorphism and the risk of prostate cancer. A total of 3,206 cases and 3,880 controls from eight case-control studies were included for data synthesis. The overall results suggested no significant association between the polymorphism and the risk of prostate cancer (OR=1.01, 95% CI=0.92-1.11, p = 0.83 for Asp/Asp+Glu/Asp vs. Glu/Glu). In the stratified analysis according to ethnicity, no significant associations were observed in Asians and Europeans. The current meta-analysis suggested that the Glu298Asp polymorphism of the NOS3 gene might not contribute to the risk of prostate cancer.
authors.affiliation: The Periodical Press of West China Hospital, Sichuan University, Guoxuexiang 37, Chengdu, Sichuan, 610041, China.
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Jia
authors.forename: Qing
authors.initials: Q
authors.lastname: He
authors.forename: Jiani
authors.initials: J
authors.lastname: Shen
authors.forename: Jiqiao
authors.initials: J
authors.lastname: Yang
authors.forename: Pei
authors.initials: P
authors.lastname: Xue
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Ma
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.forename: Liang
authors.initials: L
authors.lastname: Du
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000209:etiology / Q000235:genetics*; D012306:Risk
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III