title: Nanocapsulated quercetin downregulates rat hepatic MMP-13 and controls diethylnitrosamine-induced carcinoma.
abstract: OBJECTIVE
  The aims of our work were to investigate the controlling role and the efficacy of nanocapsulated quercetin drug delivery system on the decrement of inflammatory mediators such as MMP-13 in diethyl nitrosamine (DEN)-induced hepatocarcinogenesis.
  
  
  METHODS
  Hepatocellular carcinoma was developed in the Swiss albino rats by the exposure of DEN. DEN administration caused the generation of reactive oxygen species, upregulation of TNF-α, IL-6, activation of MMP-13, severe oxidative damage, hyperplastic nodules with preneoplastic lesions and the histopathological changes in rat liver.
  
  
  CONCLUSIONS
  Nanocapsulated quercetin treatment restricted all alterations in DEN-mediated development of hepatocarcinogenesis. Therefore, it may be concluded that nanocapsulated quercetin may be accepted as a potent therapeutic formulation in preventing DEN-mediated hepatocarcinogenesis.
authors.affiliation: Drug Development/Diagnostics & Biotechnology Division, Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Jadavpur, Kolkata - 700032, India.
authors.forename: Ardhendu Kumar
authors.initials: AK
authors.lastname: Mandal
authors.forename: Debasree
authors.initials: D
authors.lastname: Ghosh
authors.forename: Sibani
authors.initials: S
authors.lastname: Sarkar
authors.forename: Aparajita
authors.initials: A
authors.lastname: Ghosh
authors.forename: Snehasikta
authors.initials: S
authors.lastname: Swarnakar
authors.forename: Nirmalendu
authors.initials: N
authors.lastname: Das
mesh_terms: D000818:Animals; D004052:Diethylnitrosamine / Q000633:toxicity*; D015536:Down-Regulation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D053509:Matrix Metalloproteinase 13 / Q000378:metabolism*; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats
chemical_list: D053769:Nanocapsules; D004052:Diethylnitrosamine; D011794:Quercetin; D053509:Matrix Metalloproteinase 13
keywords: MMP-13; diethyl nitrosamine; hepatocarcinogenesis; nanocapsulated quercetin; proinflammatory cytokines; reactive oxygen species