title: A quantitative trait locus for ascites on chromosome 9 in broiler chicken lines.
abstract: A genome-wide SNP survey was used to identify chromosomal regions that showed linkage disequilibrium with respect to ascites susceptibility and ventricular hypertrophy in an F2 cross between previously described ascites-resistant and -susceptible lines. Variable number tandem repeats were used to obtain genotype data to further characterize these regions. A region on chromosome 9 (12 to 13 Mbp in 2011 assembly) shows association with ascites in the ascites lines and in several commercial broiler breeder lines with a significant sex effect. There are 2 candidate genes, AGTR1 (an angiotensin II type 1 receptor) and UTS2D (urotensin 2 domain containing), in this region that have been associated with hypertension and hypoxic response in mammals.
authors.affiliation: Program in Cell and Molecular Biology, University of Arkansas, Fayetteville 72701.
authors.forename: Sriram
authors.initials: S
authors.lastname: Krishnamoorthy
authors.forename: Candace D
authors.initials: CD
authors.lastname: Smith
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Al-Rubaye
authors.forename: Gisela F
authors.initials: GF
authors.lastname: Erf
authors.forename: Robert F
authors.initials: RF
authors.lastname: Wideman
authors.forename: Nicholas B
authors.initials: NB
authors.lastname: Anthony
authors.forename: Douglas D
authors.initials: DD
authors.lastname: Rhoads
mesh_terms: D000818:Animals; D001201:Ascites / Q000235:genetics / Q000662:veterinary*; D030161:Avian Proteins / Q000235:genetics* / Q000378:metabolism; D006332:Cardiomegaly / Q000235:genetics / Q000662:veterinary*; D002645:Chickens; D004198:Disease Susceptibility / Q000662:veterinary; D055106:Genome-Wide Association Study / Q000662:veterinary; D015810:Linkage Disequilibrium; D036361:Peptide Hormones / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D011201:Poultry Diseases / Q000235:genetics*; D040641:Quantitative Trait Loci; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D030161:Avian Proteins; D036361:Peptide Hormones; D044140:Receptor, Angiotensin, Type 1
keywords: ascites; commercial broiler; hypertension; quantitative trait locus