title: Effect of ambrisentan on peripheral circulation in patients with systemic sclerosis.
abstract: Systemic sclerosis (SSc) is characterized by disturbed blood circulation. The effect of ambrisentan, an endothelin-A receptor-selective antagonist, on impaired peripheral circulation in SSc remains largely elusive. Here we show SSc patients, whose clinical symptoms such as cyanosis and Raynaud's phenomenon, were ameliorated by the treatment with ambrisentan. Additionally, objective evaluations with thermography showed improvement of hand coldness in steady-state and cold challenge tests. Ambrisentan might have a potential to improve peripheral circulation in SSc.
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Hayakazu
authors.initials: H
authors.lastname: Sumida
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.affiliation: b Department of Cardiovascular Medicine , Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Hatano
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Naohiko
authors.initials: N
authors.lastname: Aozasa
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Toyama
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Kaname
authors.initials: K
authors.lastname: Akamata
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Miyazaki
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Taniguchi
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Takehiro
authors.initials: T
authors.lastname: Takahashi
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Yohei
authors.initials: Y
authors.lastname: Ichimura
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Noda
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kuwano
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Koichi
authors.initials: K
authors.lastname: Yanaba
authors.affiliation: a Department of Dermatology , Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000368:Aged; D065130:Endothelin A Receptor Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010666:Phenylpropionates / Q000627:therapeutic use*; D011724:Pyridazines / Q000627:therapeutic use*; D011928:Raynaud Disease / Q000188:drug therapy*; D012595:Scleroderma, Systemic / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D065130:Endothelin A Receptor Antagonists; D010666:Phenylpropionates; D011724:Pyridazines; C467894:ambrisentan
keywords: Ambrisentan; Cyanosis; Raynaud's phenomenon; Systemic sclerosis; Thermography