title: Epidemiology and treatment outcomes of diabetic retinopathy in a diabetic population from Cameroon.
abstract: BACKGROUND
  Diabetic retinopathy (DR) is the most common microvascular complication of diabetes. It can lead to significant visual loss. The aim of this study was to determine the frequency and clinical profile of diabetic retinopathy, and assess the outcomes of laser photocoagulation therapy in a diabetic population in Cameroon.
  
  
  METHODS
  We carried out a prospective cohort study during 24 months in the Department of Ophthalmology of the Douala General Hospital, Cameroon. We included all diabetic patients who were referred from diabetes clinics for ophthalmologic evaluation. Data included type and duration of diabetes, visual acuity, intra-ocular pressure, results of fundoscopy and fluorescein angiography, and outcomes two months after treatment with laser photocoagulation.
  
  
  RESULTS
  We included 407 patients; 88% had type 2 diabetes. Their mean duration of diabetes was 6.4 years (SD=6.6). Forty point three percent (164/407) of patients were found to have DR on fundoscopy. Of the 164 patients with DR, 63.4% (104/164) had non-proliferative and 36.6% (60/164) had proliferative DR. Diabetic maculopathy was found in 14.5% (59/407) of all participants, and 36% (59/164) of patients with DR. There was a strong correlation between the duration of diabetes and retinopathy status (p < 0.001, r = 0.9541). Overall, 17.4% (71/407) of patients were eligible for laser photocoagulation. Of these, 66.2% (47/71) were treated, and 78.7% (37/47) of treated patients came back for control two months later. Among these treated patients an improvement of the retinopathy was noted in 73% (27/37), no change in 16.2% (6/37) and a worsening in 10.8% (4/37). Severe proliferative DR was significantly associated with treatment failure (p < 0.001).
  
  
  CONCLUSIONS
  The frequency of DR may be high among diabetic patients in Cameroon. There was a good uptake of laser photocoagulation therapy among patients affected by DR in our setting, with good treatment outcomes. Interventions to prevent diabetes and increase the precocity of diagnosis and treatment of DR should be scaled up.
authors.forename: Ahmadou M
authors.initials: AM
authors.lastname: Jingi
authors.affiliation: Internal Medicine Unit, Edéa Regional Hospital, PO Box 100, Edéa, Cameroon. noubiapjj@yahoo.fr.
authors.forename: Jean Jacques N
authors.initials: JJ
authors.lastname: Noubiap
authors.forename: Augustin
authors.initials: A
authors.lastname: Ellong
authors.forename: Jean Joel R
authors.initials: JJ
authors.lastname: Bigna
authors.forename: Côme Ebana
authors.initials: CE
authors.lastname: Mvogo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002163:Cameroon / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003930:Diabetic Retinopathy / Q000453:epidemiology* / Q000601:surgery; D005260:Female; D006801:Humans; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult