title: NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides.
abstract: An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2-alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3-stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.
authors.affiliation: Department of Chemistry and Research Institute for Natural Sciences, Hanyang University, Seoul 133-791, Korea. sowony73@hanyang.ac.kr.
authors.forename: So Won
authors.initials: SW
authors.lastname: Youn
authors.forename: Hyoung Sub
authors.initials: HS
authors.lastname: Song
authors.forename: Jong Hyub
authors.initials: JH
authors.lastname: Park
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D001572:Benzofurans; D006571:Heterocyclic Compounds; C030011:carbene; C082022:phthalide; D008697:Methane