title: GIP/MZT1 proteins orchestrate nuclear shaping.
abstract: The functional organization of the nuclear envelope (NE) is only just emerging in plants with the recent characterization of NE protein complexes and their molecular links to the actin cytoskeleton. The NE also plays a role in microtubule nucleation by recruiting γ-Tubulin Complexes (γ-TuCs) which contribute to the establishment of a robust mitotic spindle. γ-tubulin Complex Protein 3 (GCP3)-interacting proteins (GIPs) have been identified recently as integral components of γ-TuCs. GIPs have been conserved throughout evolution and are also named MZT1 (mitotic-spindle organizing protein 1). This review focuses on recent data investigating the role of GIP/MZT1 at the NE, including insights from the study of GIP partners. It also uncovers new functions for GIP/MZT1 during interphase and highlights a current view of NE-associated components which are critical for nuclear shaping during both cell division and differentiation.
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, UPR 2357, Conventionné avec l'Université de Strasbourg Strasbourg, France.
authors.forename: Morgane
authors.initials: M
authors.lastname: Batzenschlager
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, UPR 2357, Conventionné avec l'Université de Strasbourg Strasbourg, France.
authors.forename: Etienne
authors.initials: E
authors.lastname: Herzog
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, UPR 2357, Conventionné avec l'Université de Strasbourg Strasbourg, France.
authors.forename: Guy
authors.initials: G
authors.lastname: Houlné
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, UPR 2357, Conventionné avec l'Université de Strasbourg Strasbourg, France.
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Schmit
authors.affiliation: Institut de Biologie Moléculaire des Plantes, Centre National de la Recherche Scientifique, UPR 2357, Conventionné avec l'Université de Strasbourg Strasbourg, France.
authors.forename: Marie-Edith
authors.initials: ME
authors.lastname: Chabouté
keywords: Arabidopsis thaliana; gamma-tubulin complex; nuclear envelope proteins; nucleocytoplasmic continuum; spindle assembly