title: Aqueous extract of pecan nut shell (Carya illinoensis [Wangenh.] K. Koch) exerts protection against oxidative damage induced by cyclophosphamide in rat testis.
abstract: This study investigated the protective effect of pecan nut (Carya illinoensis) shell aqueous extract (AE) on the oxidative and morphological status of rat testis treated with cyclophosphamide (CP). Wistar rats received water or AE (5%) ad libitum for 37 days. On day 30, half of each group received a single intraperitoneal administration of vehicle or CP 200 mg/kg. After 7 days, the animals were killed and their testis removed. Rats treated with CP presented reduced levels of lactate dehydrogenase, vitamin C, and gluthatione, as well as decreased catalase activity, increased lipid peroxidation levels and superoxide dismutase activity, no alteration in carbonyl protein levels, and a loss of morphological testicular integrity. In contrast, cotreatment with pecan shell AE totally prevented the decrease of lactate dehydrogenase and vitamin C levels and catalase activity and partially prevented the depletion of gluthatione levels. Moreover, it totally prevented the increase in superoxide dismutase activity and lipid peroxidation levels and maintained testicular integrity. These findings show the protective role of pecan shell AE in CP-induced testicular toxicity. The use of this phytotherapy may be considered to minimize deleterious effects related to this chemotherapy.
authors.affiliation: Universidade Federal da Fronteira Sul.
authors.forename: Dalila M
authors.initials: DM
authors.lastname: Benvegnu
authors.affiliation: Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Raquel C S
authors.initials: RC
authors.lastname: Barcelos
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Katiane
authors.initials: K
authors.lastname: Roversi
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil.
authors.forename: Nardelli
authors.initials: N
authors.lastname: Boufleur
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil.
authors.forename: Camila S
authors.initials: CS
authors.lastname: Pase
authors.affiliation: Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Trevizol
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Hecson J
authors.initials: HJ
authors.lastname: Segat
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Verônica T
authors.initials: VT
authors.lastname: Dias
authors.affiliation: Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Geisa S
authors.initials: GS
authors.lastname: Dolci
authors.affiliation: Programa de pos-Graduacao em Farmacologia, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Caren T D
authors.initials: CT
authors.lastname: Antoniazzi
authors.affiliation: Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria, RS, Brazil.
authors.forename: Patricia
authors.initials: P
authors.lastname: Reckziegel
authors.affiliation: Departamento de Quimica, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Lima
authors.affiliation: Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Pernambuco, Brazil.
authors.forename: Luiz A R
authors.initials: LA
authors.lastname: de Lima
authors.affiliation: Departamento de Quimica, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil.
authors.forename: Leandro M
authors.initials: LM
authors.lastname: de Carvalho
authors.affiliation: Departamento de Morfologia e Fisiologia Animal, Universidade Federal Rural de Pernambuco, Pernambuco, Brazil.
authors.forename: Valdemiro A
authors.initials: VA
authors.lastname: da Silva Junior
authors.affiliation: Programa de pós Graduação em Farmacologia, Universidade Federal de Santa Maria, RS, Brazil.
authors.forename: Marilise E
authors.initials: ME
authors.lastname: Burger
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D031325:Carya; D002374:Catalase / Q000378:metabolism; D003520:Cyclophosphamide / Q000009:adverse effects / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D023421:Models, Animal; D009754:Nuts; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013737:Testis / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*
chemical_list: D010936:Plant Extracts; D003520:Cyclophosphamide; D007770:L-Lactate Dehydrogenase; D002374:Catalase; D013482:Superoxide Dismutase; D001205:Ascorbic Acid