title: Adverse drug reactions of spontaneous reports in Shanghai pediatric population.
abstract: BACKGROUND
  Knowledge of drug safety in the pediatric population of China is limited. This study was designed to evaluate ADRs in children reported to the spontaneous reporting system (SRS) of Shanghai in 2009.
  
  
  RESULTS
  Crude ADR reports submitted to Shanghai SRS in 2009 for individuals aged from birth to 17 years (including 17 years) were included. Data were analyzed with respect to age, gender, category of ADR (System Organ Class [SOC]), the severity of reports and type of reporter.
  
  
  RESULTS
  A male overrepresentation was observed regarding the total number of reports. The most frequently reported group of drugs were vaccines (42.15%). Skin rash and fever were the commonest symptoms reported in the total pediatric dataset. The proportion of children that suffered from a serious ADR was 2.16% and that for drug related deaths was 0.34%. And we found that the multiple drug exposure experienced a high proportion of serious ADRs compared with the single drug use (χ² = 15.99, P<0.0001). Sixty-five percent of ADRs were for children less than 6 years of age. And more than half of reports were from doctors.
  
  
  CONCLUSIONS
  In our study, consumers were more likely to report new ADRs though they appear to contribute a relatively small percentage of total reports. We propose that patients would take an active role in reporting ADRs. More researches are needed in order to achieve better understanding the characteristics of ADRs in pediatric population of China.
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Xiao-Jing
authors.initials: XJ
authors.lastname: Guo
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Ye
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China ; Department of politics, Second Military Medical University, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.affiliation: Adverse Drug Reaction Monitoring Center of Shanghai, Shanghai, China.
authors.forename: Wen-Min
authors.initials: WM
authors.lastname: Du
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Jin-Fang
authors.initials: JF
authors.lastname: Xu
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Xin-Ji
authors.initials: XJ
authors.lastname: Zhang
authors.affiliation: Department of Health Statistics, Second Military Medical University, Shanghai, China.
authors.forename: Jia
authors.initials: J
authors.lastname: He
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003256:Community Participation / Q000706:statistics & numerical data*; D064420:Drug-Related Side Effects and Adverse Reactions / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D012737:Sex Factors; D014612:Vaccines / Q000009:adverse effects*
chemical_list: D014612:Vaccines