title: Self-antigen presentation by dendritic cells in autoimmunity.
abstract: The operation of both central and peripheral tolerance ensures the prevention of autoimmune diseases. The maintenance of peripheral tolerance requires self-antigen presentation by professional antigen presenting cells (APCs). Dendritic cells (DCs) are considered as major APCs involved in this process. The current review discusses the role of DCs in autoimmune diseases, the various factors involved in the induction and maintenance of tolerogenic DC phenotype, and pinpoints their therapeutic capacity as well as potential novel targets for future clinical studies.
authors.affiliation: Department of Medicine II, Saarland University Medical Center , Homburg , Germany.
authors.forename: Ann-Katrin
authors.initials: AK
authors.lastname: Hopp
authors.affiliation: Department of Medicine II, Saarland University Medical Center , Homburg , Germany.
authors.forename: Anne
authors.initials: A
authors.lastname: Rupp
authors.affiliation: Department of Medicine II, Saarland University Medical Center , Homburg , Germany.
authors.forename: Veronika
authors.initials: V
authors.lastname: Lukacs-Kornek
keywords: dendritic cell subtypes and autoimmunity; peripheral tolerance; self-antigen presentation; tolerogenic dendritic cells