title: Phosphorous-containing polymers for regenerative medicine.
abstract: Disease and injury have resulted in a large, unmet need for functional tissue replacements. Polymeric scaffolds can be used to deliver cells and bioactive signals to address this need for regenerating damaged tissue. Phosphorous-containing polymers have been implemented to improve and accelerate the formation of native tissue both by mimicking the native role of phosphorous groups in the body and by attachment of other bioactive molecules. This manuscript reviews the synthesis, properties, and performance of phosphorous-containing polymers that can be useful in regenerative medicine applications.
authors.affiliation: Department of Bioengineering, Rice University, 6500 Main Street, Houston, TX 77030, USA.
authors.forename: Brendan M
authors.initials: BM
authors.lastname: Watson
authors.forename: F Kurtis
authors.initials: FK
authors.lastname: Kasper
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Mikos
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry*; D001861:Bone Regeneration; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000737:chemistry; D002462:Cell Membrane / Q000378:metabolism; D006801:Humans; D010758:Phosphorus / Q000737:chemistry*; D010767:Phosphorylcholine / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D013314:Stress, Mechanical; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D011506:Proteins; D010767:Phosphorylcholine; D010758:Phosphorus; D002118:Calcium