title: Bioartificial fabrication of regenerating blood vessel substitutes: requirements and current strategies.
abstract: This work reviews the tremendous development in the field of vascular graft tissue engineering driven by a clear and increasing clinical need for functional vascular replacements able to grow and remodel. The different strategies to tissue engineer blood vessels are presented, from the classical approach of a living implant generated in vitro by conditioning a cell-seeded scaffold to remarkable paradigm shifts either i) toward a completely biology-driven strategy (scaffold-free approaches) or ii) the opposite tendency of cell-free scaffolds aiming at eliciting the host reaction for in situ tissue engineering. In the scaffold-based approaches emphasis is given to the material choice.
authors.forename: Mathias
authors.initials: M
authors.lastname: Wilhelmi
authors.forename: Stefan
authors.initials: S
authors.lastname: Jockenhoevel
authors.forename: Petra
authors.initials: P
authors.lastname: Mela
mesh_terms: D000818:Animals; D021522:Bioartificial Organs; D001807:Blood Vessel Prosthesis; D001808:Blood Vessels / Q000166:cytology* / Q000254:growth & development*; D006801:Humans; D011474:Prosthesis Design; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering / Q000295:instrumentation*; D054457:Tissue Scaffolds