title: Psychosocial job strain and risk of congenital malformations in offspring--a Danish National cohort study.
abstract: OBJECTIVE
  To investigate if maternal exposure to psychosocial job strain at work (high demands and low control) measured by questionnaire early in pregnancy (median week 15) is associated with malformations in the offspring.
  
  
  METHODS
  Population-based cohort study.
  
  
  METHODS
  The Danish National Birth Cohort.
  
  
  METHODS
  A cohort of 60,386 singleton children with full information on mother's occupational status, exposure to psychosocial job strain and all covariates during pregnancy.
  
  
  METHODS
  Logistic regression analysis was used to calculate the odds of congenital malformations as a function of job strain with adjustment for maternal age, body mass index, parity, smoking, alcohol use, manual versus nonmanual work, maternal serious disease and gestational age at interview.
  
  
  METHODS
  Circulatory malformation, musculoskeletal malformation or any malformation.
  
  
  RESULTS
  Logistic regression analyses, both crude and adjusted, indicated no associations between working under high strain and giving birth to a child with circulatory malformation (adjusted odds ratio [OR] 1.04, 95% confidence interval [95% CI] 0.75-1.44), musculoskeletal malformation (aOR 0.88, 95% CI 0.71-1.10) or any malformation (aOR 0.99, 95% CI 0.85-1.15). Supplementary analyses including restriction to first-borns and a stratified analysis with respect to manual and nonmanual work did not change the results.
  
  
  CONCLUSIONS
  Association between exposure to high job strain during pregnancy and elevated risk of circulatory, muscle and any malformations is not supported by this study.
authors.affiliation: National Research Centre for the Working Environment, Copenhagen, Denmark; Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: A D
authors.initials: AD
authors.lastname: Larsen
authors.forename: H
authors.initials: H
authors.lastname: Hannerz
authors.forename: A M
authors.initials: AM
authors.lastname: Thulstrup
authors.forename: J P
authors.initials: JP
authors.lastname: Bonde
authors.forename: C
authors.initials: C
authors.lastname: Obel
authors.forename: K S
authors.initials: KS
authors.lastname: Hougaard
mesh_terms: D000328:Adult; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000453:epidemiology*; D003718:Denmark; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009784:Occupational Diseases / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000523:psychology*; D012307:Risk Factors; D013315:Stress, Psychological / Q000453:epidemiology; D055815:Young Adult
keywords: Birth cohort; cohort study; congenital malformations; high demands; influence at work; job strain