title: Cytotoxicity and antimicrobial activities of green synthesized silver nanoparticles.
abstract: Bio-inspired silver nanoparticles are synthesized using Malus domestica (apple) extract. Polyphenols present in the apple extract act as a reducing and capping agent to produce the silver nanoparticles. UV-Visible analysis shows the surface plasmon resonance (SPR) absorption at 420 nm. The FTIR analysis was used to identify the functional groups responsible for the bio-reduction of silver ion. The XRD and HRTEM images confirm the formation of silver nanoparticles. The minimal inhibitory concentration (MIC) of silver nanoparticles was recorded against most of the bacteria and fungus. Further, MCF-7 human breast adenocarcinoma cancer cell line was employed to observe the efficacy of cancer cell killing.
authors.affiliation: Department of Inorganic Chemistry, School of Chemical Sciences, University of Madras, Guindy Maraimalai Campus, Chennai 600025, India.
authors.forename: S
authors.initials: S
authors.lastname: Lokina
authors.affiliation: Department of Nuclear Physics, University of Madras, Guindy Maraimalai Campus, Chennai 600025, India.
authors.forename: A
authors.initials: A
authors.lastname: Stephen
authors.affiliation: CAS in Botany, University of Madras, Guindy Maraimalai Campus, Chennai 600025, India.
authors.forename: V
authors.initials: V
authors.lastname: Kaviyarasan
authors.affiliation: Department of Zoology, University of Madras, Guindy Maraimalai Campus, Chennai 600025, India.
authors.forename: C
authors.initials: C
authors.lastname: Arulvasu
authors.affiliation: Department of Inorganic Chemistry, School of Chemical Sciences, University of Madras, Guindy Maraimalai Campus, Chennai 600025, India. Electronic address: vnnara@unom.ac.in.
authors.forename: V
authors.initials: V
authors.lastname: Narayanan
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D006801:Humans; D061986:MCF-7 Cells; D053768:Metal Nanoparticles; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D012834:Silver / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D012834:Silver
keywords: Antimicrobial activity; Apple; Cytotoxicity; MCF-7 cells; Silver nanoparticles