title: Sorafenib for Egyptian patients with advanced hepatocellular carcinoma; single center experience.
abstract: BACKGROUND
  According to the results of a number of phase 3 randomized studies, sorafenib is the only approved systemic therapy for advanced HCC; however the issue of high economic cost remains challenging; thus we have conducted this retrospective analysis of our HCC patients treated with sorafenib.
  
  
  METHODS
  HCC patients treated at Ain Shams University Hospitals, in the period between 2010 and 2012 were reviewed. Eligible patients were those who had received sorafenib for advanced HCC not eligible for or progressed after surgery or locoregional therapy. We investigated the impact of baseline clinicopathological factors (age, gender, child status, performance score, BCLC tumor stage, cause of chronic liver disease, median baseline alpha fetoprotein level and previous treatment received for HCC) on overall survival (OS) in an adjusted Cox regression model.
  
  
  RESULTS
  41 patients were included in the analysis fulfilling the inclusion criteria. At a median follow up period of 13 months, the median PFS for the whole group was 4 months; the median OS for the whole group is 6.25 months. Multivariate analysis identified three baseline characteristics that were prognostic indicators for overall survival: ECOG performance status (median OS for ECOG 1=7.01 months and for ECOG 2=3.03 months), Child-Pugh status (median OS for child A=12.04 months and for child B=5.23 months), and median baseline levels of alpha-fetoprotein.
  
  
  CONCLUSIONS
  In limited resource countries like Egypt, we suggest that the use of sorafenib for the treatment of advanced HCC cases should be restricted to a highly selected subgroup of patients with good performance and child A.
authors.affiliation: Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Abbaseya Square, Cairo, Egypt. Electronic address: omar.abdelrhman@med.asu.edu.eg.
authors.forename: Omar
authors.initials: O
authors.lastname: Abdel-Rahman
authors.affiliation: Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Abbaseya Square, Cairo, Egypt.
authors.forename: Manal
authors.initials: M
authors.lastname: Abdelwahab
authors.affiliation: Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Abbaseya Square, Cairo, Egypt.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Shaker
authors.affiliation: Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Abbaseya Square, Cairo, Egypt.
authors.forename: Sherif
authors.initials: S
authors.lastname: Abdelwahab
authors.affiliation: Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Abbaseya Square, Cairo, Egypt.
authors.forename: Mohammed
authors.initials: M
authors.lastname: Elbassiony
authors.affiliation: Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Abbaseya Square, Cairo, Egypt.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Ellithy
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D004334:Drug Administration Schedule; D004534:Egypt; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives*; D010671:Phenylurea Compounds / Q000008:administration & dosage*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D000077157:Sorafenib; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D010671:Phenylurea Compounds; D009536:Niacinamide; D000077157:Sorafenib
keywords: Hepatocellular carcinoma; Sorafenib