title: From radiobiology to technology: what is changing in radiotherapy for prostate cancer.
abstract: In the last decades, new technologies have been introduced in the daily clinical practice of the radiation oncologist: 3D-Conformal radiotherapy (RT) became almost universally available, thereafter, intensity modulated RT (IMRT) gained large diffusion, due to its potential impact in improving the clinical outcomes, and more recently, helical and volumetric arc IMRT with image-guided RT are becoming more and more diffused and used for prostate cancer patients. The conventional dose-fractionation results to be the best compromise between the efficacy and the safety of the treatment, but combining new techniques, modern RT allows to overcame one of the major limits of the 'older' RT: the impossibility of delivering higher total doses and/or high dose/fraction. The evidences regarding radiobiology, clinical and technological evolution of RT in prostate cancer have been reported and discussed.
authors.affiliation: Radiation Oncology Department, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne, Switzerland.
authors.forename: Berardino
authors.initials: B
authors.lastname: De Bari
authors.forename: Alba
authors.initials: A
authors.lastname: Fiorentino
authors.forename: Stefano
authors.initials: S
authors.lastname: Arcangeli
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Franco
authors.forename: Rolando Maria
authors.initials: RM
authors.lastname: D'Angelillo
authors.forename: Filippo
authors.initials: F
authors.lastname: Alongi
mesh_terms: D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011878:Radiotherapy / Q000379:methods*