title: Nutrients utilization in obese individuals with and without hypertriglyceridemia.
abstract: BACKGROUND
  Low fat utilization is linked to weight gain and to the presence of certain atherosclerosis markers. It is not clear whether the presence of hyperlipidemia can further affect nutrients utilization. The main objective of this study was to investigate the fasting fuel utilization of obese subjects suffering from hypertriglyceridemia, and to compare it with that of individuals that are solely obese.
  
  
  METHODS
  We recruited 20 obese individuals with hypertriglyceridemia and 20 matched individuals not affected by hypertriglyceridemia. The fuel utilization (respiratory quotient) was measured by respiratory gas exchange, by Indirect Calorimetry.
  
  
  RESULTS
  There was a significant difference in fuel utilization and HDL-cholesterol between cases and controls (respiratory quotient 0.89 ± 0.07 vs. 0.84 ± 0.06; p = 0.020 respectively). The univariate and multivariate linear regression analysis confirmed that hypertrygliceridemia was positively correlated to the respiratory quotient (p = 0.035).
  
  
  CONCLUSIONS
  obese subjects with hypertriglyceridemia had a higher respiratory quotient in comparison to unaffected subjects. This could suggest a limitation in the beta-oxidation mechanisms; this could actually imply that fatty acids may be redirected from oxidation to reesterification into triglycerides. The study could suggest the presence of different mechanisms unrelated to obesity and also a potential new therapeutic target for hypertriglyceridemia management.
authors.affiliation: Clinical Nutrition Unit, Department of Medical and Surgical Science, University Magna Grecia, Catanzaro 88100, Italy. tmontalcini@unicz.it.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Montalcini
authors.affiliation: Clinical Nutrition Unit, Department of Medical and Surgical Science, University Magna Grecia, Catanzaro 88100, Italy. tlamprinoudi@hotmail.it.
authors.forename: Theodora
authors.initials: T
authors.lastname: Lamprinoudi
authors.affiliation: Clinical Nutrition Unit, Department of Medical and Surgical Science, University Magna Grecia, Catanzaro 88100, Italy. attiliom88@gmail.com.
authors.forename: Attilio
authors.initials: A
authors.lastname: Morrone
authors.affiliation: Clinical Nutrition Unit, Department of Medical and Surgical Science, University Magna Grecia, Catanzaro 88100, Italy. elisamazza@inwind.it.
authors.forename: Elisa
authors.initials: E
authors.lastname: Mazza
authors.affiliation: Diabetes, Endocrine-metabolic Dis. Cardiovasc. Prevention Unit, Clinical Inst. "Beato Matteo", Department of Internal Medicine, I.R.C.C.S. Policlinico San Donato Milanese, Vigevano 27029, Italy. c.gazzaruso@gmail.com.
authors.forename: Carmine
authors.initials: C
authors.lastname: Gazzaruso
authors.affiliation: Clinical Nutrition Unit, Department of Medical and Surgical Science, University Magna Grecia, Catanzaro 88100, Italy. romeo@unicz.it.
authors.forename: Stefano
authors.initials: S
authors.lastname: Romeo
authors.affiliation: Clinical Nutrition Unit, Department of Medical and Surgical Science, University Magna Grecia, Catanzaro 88100, Italy. pujia@unicz.it.
authors.forename: Arturo
authors.initials: A
authors.lastname: Pujia
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D002153:Calorimetry, Indirect; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D002149:Energy Intake; D005215:Fasting; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000150:complications / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008019:Life Style; D016014:Linear Models; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage*; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood / Q000150:complications / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D007328:Insulin; D018977:Micronutrients; D014280:Triglycerides