title: Cell-cell interaction in the heart via Wnt/β-catenin pathway after cardiac injury.
abstract: The adult mammalian heart predominantly comprises myocytes, fibroblasts, endothelial cells, smooth muscle cells, and epicardial cells arranged in a precise three-dimensional framework. Following cardiac injury, the spatial arrangement of cells is disrupted as different populations of cells are recruited to the heart in a temporally regulated manner. The alteration of the cellular composition of the heart after cardiac injury thus enables different phenotypes of cells to interact with each other in a spatio-temporal-dependent manner. It can be argued that the integrated study of such cellular interactions rather than the examination of single populations of cells can provide more insights into the biology of cardiac repair especially at an organ-wide level. Many signalling systems undoubtedly mediate such cross talk between cells after cardiac injury. The Wnt/β-catenin system plays an important role during cardiac development and disease. Here, we describe how cell populations in the heart after cardiac injury mediate their interactions via the Wnt/β-catenin pathway, determine how such interactions can affect a cardiac repair response and finally suggest an integrated approach to study cardiac cellular interactions.
authors.affiliation: Division of Cardiology, Department of Medicine, Cardiovascular Research Laboratory, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, Programs in Molecular Cellular and Integrative Physiology and Cell and Developmental Biology, David Geffen School of Medicine, University of California, Los Angeles, 675 Charles E Young Drive S, MRL 3609, Los Angeles, CA 90095, USA.
authors.forename: Arjun
authors.initials: A
authors.lastname: Deb
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology*; D006321:Heart / Q000502:physiology / Q000503:physiopathology*; D006335:Heart Injuries / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D060449:Wnt Signaling Pathway / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051176:beta Catenin
keywords: Hypertrophy; Infarction; Interactome; Wnt; β-Catenin