title: Peptide-directed spatial organization of biomolecules in dynamic gradient scaffolds.
abstract: Specific binding peptides are used to spatially organize biomolecule gradients within an electrospun fiber scaffold. Different biomolecule-binding peptide-polymer conjugates are sequentially co-electrospun with a fiber-forming host polymer to generate opposing gradients of peptide functionalization. The binding peptides specifically and non-covalently guide the spatial arrangement of biomolecules into dynamic gradients within the scaffold, mimicking biological gradients found in native tissues.
authors.affiliation: Department of Materials, Imperial College London, SW7 2AZ, UK; Institute for Biomedical Engineering, Imperial College London, SW7 2AZ, UK.
authors.forename: Lesley W
authors.initials: LW
authors.lastname: Chow
authors.forename: Astrid
authors.initials: A
authors.lastname: Armgarth
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: St-Pierre
authors.forename: Sergio
authors.initials: S
authors.lastname: Bertazzo
authors.forename: Cristina
authors.initials: C
authors.lastname: Gentilini
authors.forename: Claudia
authors.initials: C
authors.lastname: Aurisicchio
authors.forename: Seth D
authors.initials: SD
authors.lastname: McCullen
authors.forename: Joseph A M
authors.initials: JA
authors.lastname: Steele
authors.forename: Molly M
authors.initials: MM
authors.lastname: Stevens
mesh_terms: D055664:Electrochemical Techniques; D006820:Hyaluronic Acid / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010455:Peptides / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D010455:Peptides; D011091:Polyesters; C016240:polycaprolactone; D006820:Hyaluronic Acid
keywords: biomimetic materials; hierarchical organization; peptide-polymer conjugates; surface functionalization; tissue engineering