title: Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes.
abstract: Cardiac hypertrophy is an independent risk factor for cardiovascular disease and its subsequent progression to heart failure represents a major cause of morbidity and mortality in the world. CGA is an important component of Chinese herbal medicine, acting as an antioxidant, scavenging free radicals and preventing inflammation. This study found that with the pre-treatment of chlorogenic acid in Iso-induced neonatal rat myocytes, the levels of the hypertrophic markers, ANP, BNP and β-MHC decreased. The nuclear translocation of NF-κB was blocked, whereas NF-κBIA, an inhibitor of NF-κB, was upregulated accordingly. And the level of the intracellular ROS was also reduced. These data reveal that chlorogenic acid may inhibit Iso-induced cardiac hypertrophy by attenuating NF-κB signaling pathway and suppressing ROS.
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai, China; Tongji University School of Medicine, Shanghai, China.
authors.forename: Yanfei
authors.initials: Y
authors.lastname: Li
authors.affiliation: Tongji University School of Medicine, Shanghai, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Shen
authors.affiliation: Tongji University School of Medicine, Shanghai, China.
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Tang
authors.affiliation: Tongji University School of Medicine, Shanghai, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.affiliation: Tongji University School of Medicine, Shanghai, China.
authors.forename: Da
authors.initials: D
authors.lastname: Wo
authors.affiliation: Tongji University School of Medicine, Shanghai, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Yan
authors.affiliation: Tongji University School of Medicine, Shanghai, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Song
authors.affiliation: Tongji University School of Medicine, Shanghai, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Feng
authors.affiliation: School of Life Sciences and Technology, Tongji University, Shanghai, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.affiliation: Tongji University School of Medicine, Shanghai, China. Electronic address: jiezhang@tongji.edu.cn.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.affiliation: Tongji University School of Medicine, Shanghai, China. Electronic address: jueli@tongji.edu.cn.
authors.forename: Jue
authors.initials: J
authors.lastname: Li
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D006332:Cardiomegaly / Q000139:chemically induced / Q000517:prevention & control*; D002478:Cells, Cultured; D002726:Chlorogenic Acid / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology*; D032383:Myocytes, Cardiac / Q000378:metabolism / Q000473:pathology*; D016328:NF-kappa B / Q000502:physiology; D021381:Protein Transport / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D016328:NF-kappa B; D017382:Reactive Oxygen Species; D002726:Chlorogenic Acid; D007545:Isoproterenol
keywords: Cardiac hypertrophy; Chlorogenic acid; Isoproterenol; ROS