title: The role of lymph node sinus macrophages in host defense.
abstract: Strategically positioned along lymphatic vessels, lymph nodes act as filter stations preventing systemic pathogen dissemination; they are primary sites of innate immune responses and provide the staging grounds for the generation of adaptive immunity. Critical mediators of these lymph node functions are two phenotypically and functionally distinct subsets of macrophages: the subcapsular sinus macrophages and the medullary macrophages. This review focuses on the phenotype and function of these lymph node sinus-resident macrophages and summarizes methods for their proper identification and experimental manipulation.
authors.affiliation: Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy.
authors.forename: Mirela
authors.initials: M
authors.lastname: Kuka
authors.forename: Matteo
authors.initials: M
authors.lastname: Iannacone
mesh_terms: D000818:Animals; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D008264:Macrophages / Q000276:immunology* / Q000473:pathology
keywords: CD169; antiviral immunity; lymph node; macrophages; medullary sinus; subcapsular sinus