title: Polymorphisms of ATF6B Are Potentially Associated With FEV1 Decline by Aspirin Provocation in Asthmatics.
abstract: OBJECTIVE
  Endoplasmic reticulum (ER) stress has recently been observed to activate NF-kappaB and induce inflammatory responses such as asthma. Activating transcription factor 6β (ATF6B) is known to regulate ATFα-mediated ER stress response. The aim of this study is to investigate the associations of ATF6B genetic variants with aspirin-exacerbated respiratory disease (AERD) and its major phenotype, % decline of FEV1 by aspirin provocation.
  
  
  METHODS
  Four common single nucleotide polymorphisms (SNPs) of ATF6B were genotyped and statistically analyzed in 93 AERD patients and 96 aspirin-tolerant asthma (ATA) as controls.
  
  
  RESULTS
  Logistic analysis revealed that 2 SNPs (rs2228628 and rs8111, P=0.008; corrected P=0.03) and 1 haplotype (ATF6B-ht4, P=0.005; corrected P=0.02) were significantly associated with % decline of FEV1 by aspirin provocation, whereas ATF6B polymorphisms and haplotypes were not associated with the risk of AERD.
  
  
  CONCLUSIONS
  Although further functional and replication studies are needed, our preliminary findings suggest that ATF6B may be related to obstructive phenotypes in response to aspirin exposure in adult asthmatics.
authors.affiliation: Department of Life Science, Sogang University, Seoul, Korea.
authors.forename: Tae-Joon
authors.initials: TJ
authors.lastname: Park
authors.affiliation: Department of Life Science, Sogang University, Seoul, Korea.
authors.forename: Jeong-Hyun
authors.initials: JH
authors.lastname: Kim
authors.affiliation: Department of Life Science, Sogang University, Seoul, Korea.
authors.forename: Charisse F
authors.initials: CF
authors.lastname: Pasaje
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea.
authors.forename: Byung-Lae
authors.initials: BL
authors.lastname: Park
authors.affiliation: Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea.
authors.forename: Joon Seol
authors.initials: JS
authors.lastname: Bae
authors.affiliation: Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
authors.forename: Soo-Taek
authors.initials: ST
authors.lastname: Uh
authors.affiliation: Division of Allergy and Respiratory Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.
authors.forename: Yong-Hoon
authors.initials: YH
authors.lastname: Kim
authors.affiliation: Department of Internal Medicine, Chungbuk National University, College of Medicine, Cheongju, Korea.
authors.forename: Mi-Kyeong
authors.initials: MK
authors.lastname: Kim
authors.affiliation: Department of Allergy, Chonnam National University Medical School and Research Institute of Medical Sciences, Gwangju, Korea.
authors.forename: Inseon S
authors.initials: IS
authors.lastname: Choi
authors.affiliation: Division of Pulmonary and Allergy, Department of Internal Medicine, Chung-Ang University Yongsan Hospital, Seoul, Korea.
authors.forename: Byoung Whui
authors.initials: BW
authors.lastname: Choi
authors.affiliation: Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
authors.forename: Hye-Rim
authors.initials: HR
authors.lastname: Shin
authors.affiliation: Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
authors.forename: Jong-Sook
authors.initials: JS
authors.lastname: Park
authors.affiliation: Department of Physiology, College of Medicine, Hanyang University, Seoul, Korea.
authors.forename: Insong
authors.initials: I
authors.lastname: Koh
authors.affiliation: Genome Research Center for Allergy and Respiratory Diseases, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
authors.forename: Choon-Sik
authors.identifier: 0000-0003-2977-0255
authors.initials: CS
authors.lastname: Park
authors.affiliation: Department of Life Science, Sogang University, Seoul, Korea. ; Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, Korea.
authors.forename: Hyoung Doo
authors.initials: HD
authors.lastname: Shin
keywords: ATF6B; aspirin exacerbated respiratory disease (AERD); haplotype; single nucleotide polymorphism (SNP)