title: Food and drug interactions: a general review.
abstract: Although it is well known and identified that drug-drug interactions exist, the recognition of importance of food and drug interactions to practice has been growing much slower. On the other hand, drug-food/nutrient interactions continue to grow with the common use of medications. Beside the awareness of this type of interactions, food-drug interaction studies are critical to evaluate appropriate dosing, timing, and formulation of new drug candidates. Drug-food interactions take place mechanistically due to altered intestinal transport and metabolism, or systemic distribution, metabolism and excretion. In addition, some people have greater risk of food and drug interactions who have a poor diet, have serious health problems, childrens and pregnant women. In this article, basic informations about importance, classifications, transporters and enzymes of drug and nutrient interaction are given and some specific examples of both drug and nutrients and influences on each other are included.
authors.affiliation: Department of Food Engineering, Ege University of Izmir, Turkey.
authors.forename: Semih
authors.initials: S
authors.lastname: Ötles
authors.affiliation: Department of Food Engineering, Ege University of Izmir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Senturk
mesh_terms: D001682:Biological Availability; D019587:Dietary Supplements / Q000009:adverse effects; D018565:Food-Drug Interactions; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects; D009752:Nutritional Status; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010599:Pharmacokinetics; D012307:Risk Factors; D014675:Vegetables / Q000737:chemistry
chemical_list: D004364:Pharmaceutical Preparations