title: Significant SNPs have limited prediction ability for thyroid cancer.
abstract: Recently, five thyroid cancer significantly associated genetic variants (rs965513, rs944289, rs116909374, rs966423, and rs2439302) have been discovered and validated in two independent GWAS and numerous case-control studies, which were conducted in different populations. We genotyped the above five single nucleotide polymorphisms (SNPs) in Han Chinese populations and performed thyroid cancer-risk predictions with nine machine learning methods. We found that four SNPs were significantly associated with thyroid cancer in Han Chinese population, while no polymorphism was observed for rs116909374. Small familial relative risks (1.02-1.05) and limited power to predict thyroid cancer (AUCs: 0.54-0.60) indicate limited clinical potential. Four significant SNPs have limited prediction ability for thyroid cancer.
authors.affiliation: State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, China; Human Genetics Center, University of Texas School of Public Health, Houston, Texas, 77030.
authors.forename: Shicheng
authors.initials: S
authors.lastname: Guo
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: Wang
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Jin
authors.forename: Momiao
authors.initials: M
authors.lastname: Xiong
authors.forename: Qing-Hai
authors.initials: QH
authors.lastname: Ji
authors.forename: Jiucun
authors.initials: J
authors.lastname: Wang
mesh_terms: D001185:Artificial Intelligence; D056726:Genetic Association Studies; D005828:Genetics, Population; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology
keywords: Genetic; SNPs; risk prediction; thyroid cancer