title: Polymer nanoparticle-based controlled pulmonary drug delivery.
abstract: The development of novel formulations for controlled pulmonary drug delivery purposes has gained remarkable interest in medicine. Although nanomedicine represents attractive concepts for the treatment of numerous systemic diseases, scant information is available on the controlled drug release characteristics of colloidal formulations following lung administration, which might be attributed to the lack of methods to follow their absorption and distribution behavior in the pulmonary environment.In this chapter, we describe the methods of preparation and characterization of drug-loaded polymeric nanoparticles prepared from biodegradable charge-modified branched polyesters, aerosolization of the nanosuspensions using a vibrating-mesh nebulizer, and evaluation of the pulmonary pharmacokinetics (i.e., absorption and distribution characteristics) of the nanoscale drug delivery vehicles following aerosol delivery to the airspace of an isolated lung model. The disclosed methodology may contribute to the design of advanced colloids for the treatment of respiratory disorders.
authors.affiliation: Faculté de Pharmacie, Institut Galien, Université Paris-Sud, Châtenay-Malabry, France.
authors.forename: Moritz
authors.initials: M
authors.lastname: Beck-Broichsitter
authors.forename: Alexandra C
authors.initials: AC
authors.lastname: Dalla-Bona
authors.forename: Thomas
authors.initials: T
authors.lastname: Kissel
authors.forename: Werner
authors.initials: W
authors.lastname: Seeger
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmehl
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D003102:Colloids; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics*; D004339:Drug Compounding / Q000379:methods; D065546:Drug Liberation; D005452:Fluoresceins / Q000493:pharmacokinetics*; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D053758:Nanoparticles / Q000737:chemistry*; D009330:Nebulizers and Vaporizers; D009924:Organ Culture Techniques; D010316:Particle Size; D011098:Polyglactin 910 / Q000031:analogs & derivatives* / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011817:Rabbits
chemical_list: D000336:Aerosols; D003102:Colloids; D003692:Delayed-Action Preparations; D005452:Fluoresceins; C483759:diethylaminopropyl amine-poly(vinyl alcohol)-grafted-poly(lactide-co-glycolide); C024098:6-carboxyfluorescein; D011098:Polyglactin 910; D011142:Polyvinyl Alcohol