title: Function and regulation of the endosomal fusion and fission machineries.
abstract: Organelles within the endomembrane system are connected via vesicle flux. Along the endocytic pathway, endosomes are among the most versatile organelles. They sort cargo through tubular protrusions for recycling or through intraluminal vesicles for degradation. Sorting involves numerous machineries, which mediate fission of endosomal transport intermediates and fusion with other endosomes or eventually with lysosomes. Here we review the recent advances in our understanding of these processes with a particular focus on the Rab GTPases, tethering factors, and retromer. The cytoskeleton has also been recently recognized as a central player in membrane dynamics of endosomes, and this review covers the regulation of the machineries that govern the formation of branched actin networks through the WASH and Arp2/3 complexes in relation with cargo recycling and endosomal fission.
authors.affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, CNRS UPR3082, 91190 Gif-sur-Yvette, France.
authors.forename: Alexis
authors.initials: A
authors.lastname: Gautreau
authors.forename: Ksenia
authors.initials: K
authors.lastname: Oguievetskaia
authors.forename: Christian
authors.initials: C
authors.lastname: Ungermann
mesh_terms: D003599:Cytoskeleton / Q000378:metabolism / Q000502:physiology; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000502:physiology*; D008561:Membrane Fusion; D008954:Models, Biological; D020691:rab GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology
chemical_list: D020691:rab GTP-Binding Proteins