title: SV40 TAg mouse models of cancer.
abstract: The discovery of a number of viruses with the ability to induce tumours in animals and transform human cells has vastly impacted cancer research. Much of what is known about tumorigenesis today regarding tumour drivers and tumour suppressors has been discovered through experiments using viruses. The SV40 virus has proven extremely successful in generating transgenic models of many human cancer types and this review provides an overview of these models and seeks to give evidence as to their relevance in this modern era of personalised medicine and technological advancements.
authors.affiliation: Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: emily.colvin@sydney.edu.au.
authors.forename: Emily K
authors.initials: EK
authors.lastname: Colvin
authors.affiliation: Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: chris.weir@sydney.edu.au.
authors.forename: Chris
authors.initials: C
authors.lastname: Weir
authors.affiliation: Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: rowan.ikin@sydney.edu.au.
authors.forename: Rowan J
authors.initials: RJ
authors.lastname: Ikin
authors.affiliation: Bill Walsh Translational Cancer Research Laboratory, Kolling Institute of Medical Research, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales 2065, Australia. Electronic address: Amanda.Hudson@sydney.edu.au.
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Hudson
mesh_terms: D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics*; D006801:Humans; D008822:Mice, Transgenic; D009374:Neoplasms, Experimental / Q000821:virology*; D013539:Simian virus 40 / Q000235:genetics
chemical_list: D000952:Antigens, Polyomavirus Transforming
keywords: Cancer; Mouse model; SV40; Transgenic