title: An extremely rare case of pancreatic metastasis of esophageal squamous cell carcinoma.
abstract: We report a rare case of a 68-year-old male with metachronous pancreatic metastasis that was resected 2 years after salvage esophagectomy for local recurrence of esophageal squamous cell carcinoma (ESCC). Two years and 8 mo ago, he had undergone definitive chemoradiotherapy for the lower thoracic ESCC and achieved a complete response. Chemoradiotherapy used the protocol of the Japan Clinical Oncology Group trial 9906. Approximately 8 mo later, he developed a local recurrence of the ESCC and underwent thoracoscopic salvage esophagectomy followed by reconstruction with a conduit colon graft via a subcutaneous route. Recently, a tumor of the pancreatic body was found on routine follow-up computed tomography (CT). The tumor diameter was 15 mm on CT, and the maximum standardized uptake value of the lesion was 5.49 at 18F-2-fluoro-2-deoxy-D-glucose positron-emission tomography, strongly suggesting pancreatic cancer. In addition, all tumor markers were within the reference intervals. Therefore, distal pancreatectomy was performed with the resultant histological diagnosis being confirmed as pancreatic metastasis of the ESCC. He was treated with adjuvant chemotherapy, and there has been no evidence of recurrence 9 mo after the surgery. Resection of pancreatic metastasis offers a good prognosis and should be considered for solitary ESCC metastasis.
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Okamoto
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Hara
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Chin
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Motohisa
authors.initials: M
authors.lastname: Hagiwara
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Onodera
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Horii
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shirahata
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kamei
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Hashizume
authors.affiliation: Hiroshi Okamoto, Yasuyuki Hara, Masahiro Chin, Motohisa Hagiwara, Yuji Onodera, Shinichiro Horii, Yasuhiro Shirahata, Eiji Hashizume, Department of Surgery, Nihonkai General Hospital, Sakata 998-8501, Japan.
authors.forename: Noriaki
authors.initials: N
authors.lastname: Ohuchi
mesh_terms: D000368:Aged; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000556:secondary* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D000077277:Esophageal Squamous Cell Carcinoma; D016629:Esophagectomy; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000556:secondary*; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
keywords: Definitive chemoradiotherapy; Esophagus; Metachronous pancreatic metastasis; Pancreatectomy; Salvage esophagectomy; Squamous cell carcinoma