title: Prolonged usage of intravaginal clindamycin cream combined with ampicillin for the management of PPROM - a case report.
abstract: Prolonged PPROM may be catastrophic both for the mother and fetus due to ascending infections. The decision was expectant management in the setting of a spontaneous preterm premature rupture of membranes (PPROM) case and the prevention of chorioamnionitis was essential. We aimed to describe maternal and neonatal outcomes in expectant management of PPROM beginning from the 24(th) gestational week (GW) of pregnancy up to the 34(th) week under treatment with continuous usage of intravaginal clindamycin cream. We concluded that expectant active management of PPROM with antibiotics may be a suitable treatment option in carefully selected patients after receiving the patient's approval. Intravaginal clindamycin cream may be combined with systemic antibiotics (ampicillin and erythromycin) and may be a maintenance single drug for the prophylaxis of ascending vaginal infections.
authors.affiliation: Department of Gynecology and Obstetrics, Gülhane Military Medical Faculty, Ankara, Turkey.
authors.forename: Cihangir Mutlu
authors.initials: CM
authors.lastname: Ercan
authors.affiliation: Department of Family Medicine, Gülhane Military Medical Faculty, Ankara, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Aydoğan
authors.affiliation: Department of Gynecology and Obstetrics, Gülhane Military Medical Faculty, Ankara, Turkey.
authors.forename: Kazım Emre
authors.initials: KE
authors.lastname: Karaşahin
authors.affiliation: Department of Gynecology and Obstetrics, Gülhane Military Medical Faculty, Ankara, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Alanbay
authors.affiliation: Department of Gynecology and Obstetrics, Gülhane Military Medical Faculty, Ankara, Turkey.
authors.forename: Iskender
authors.initials: I
authors.lastname: Başer
keywords: Clindamycin vaginal cream; PPROM; chorioamninitis