title: A histology-based model of quantitative T1 contrast for in-vivo cortical parcellation of high-resolution 7 Tesla brain MR images.
abstract: A conclusive mapping of myeloarchitecture (myelin patterns) onto the cortical sheet and, thus, a corresponding mapping to cytoarchitecture (cell configuration) does not exist today. In this paper we present a generative model which can predict, on the basis of known cytoarchitecture, myeloarchitecture in different primary and non-primary cortical areas, resulting in simulated in-vivo quantitative T1 maps. The predicted patterns can be used in brain parcellation. Our model is validated using a similarity distance metric which enables quantitative comparison of the results with empirical data measured using MRI. The work presented may provide new perspectives for this line of research, both in imaging and in modelling the relationship with myelo- and cytoarchitecture, thus leading the way towards in-vivo histology using MRI.
authors.affiliation: Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Dinse
authors.affiliation: Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Miriam
authors.initials: M
authors.lastname: Waehnert
authors.affiliation: Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Christine Lucas
authors.initials: CL
authors.lastname: Tardif
authors.affiliation: Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Schäfer
authors.affiliation: Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Stefan
authors.initials: S
authors.lastname: Geyer
authors.affiliation: Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Robert
authors.initials: R
authors.lastname: Turner
authors.affiliation: Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
authors.forename: Pierre-Louis
authors.initials: PL
authors.lastname: Bazin
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D003198:Computer Simulation; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008953:Models, Anatomic; D008954:Models, Biological; D008959:Models, Neurological; D015233:Models, Statistical; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity