title: PLGA-based nanoparticles as cancer drug delivery systems.
abstract: Poly (lactic-co-glycolic acid) (PLGA) is one of the most effective biodegradable polymeric nanoparticles (NPs). It has been approved by the US FDA to use in drug delivery systems due to controlled and sustained- release properties, low toxicity, and biocompatibility with tissue and cells. In the present review, the structure and properties of PLGA copolymers synthesized by ring-opening polymerization of DL-lactide and glicolide were characterized using 1H nuclear magnetic resonance spectroscopy, gel permeation chromatography, Fourier transform infrared spectroscopy and differential scanning calorimetry. Methods of preparation and characterization, various surface modifications, encapsulation of diverse anticancer drugs, active or passive tumor targeting and different release mechanisms of PLGA nanoparticles are discussed. Increasing experience in the application of PLGA nanoparticles has provided a promising future for use of these nanoparticles in cancer treatment, with high efficacy and few side effects.
authors.affiliation: Department of Medical Hematology, Faculty of Advanced Medical Science, Tabriz University of Medical Science, Tabriz, Iran E-mail : Akbarzadehab@tbzmed.ac.ir, Zarghami@tbzmed.ac.ir, swjoo@yu.ac.kr.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Sadat Tabatabaei Mirakabad
authors.forename: Kazem
authors.initials: K
authors.lastname: Nejati-Koshki
authors.forename: Abolfazl
authors.initials: A
authors.lastname: Akbarzadeh
authors.forename: Mohammad Rahmati
authors.initials: MR
authors.lastname: Yamchi
authors.forename: Mortaza
authors.initials: M
authors.lastname: Milani
authors.forename: Nosratollah
authors.initials: N
authors.lastname: Zarghami
authors.forename: Vahideh
authors.initials: V
authors.lastname: Zeighamian
authors.forename: Amirbahman
authors.initials: A
authors.lastname: Rahimzadeh
authors.forename: Somayeh
authors.initials: S
authors.lastname: Alimohammadi
authors.forename: Younes
authors.initials: Y
authors.lastname: Hanifehpour
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Joo
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D009369:Neoplasms / Q000188:drug therapy*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer
chemical_list: D000970:Antineoplastic Agents; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid