title: Alternative macroautophagy and mitophagy.
abstract: Mitophagy is a mitochondrial quality control mechanism where damaged and surplus mitochondria are removed by macroautophagy. Mitophagy is associated with various physiological and pathological events such as mitochondrial clearance during terminal differentiation of reticulocytes. There are two different mammalian macroautophagy pathways: the Atg5-dependent conventional pathway and an Atg5-independent alternative pathway; the latter is involved in the erythrocyte mitophagy.
authors.affiliation: Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address: shimizu.pcb@mri.tmd.ac.jp.
authors.forename: Shigeomi
authors.initials: S
authors.lastname: Shimizu
authors.affiliation: Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Shinya
authors.initials: S
authors.lastname: Honda
authors.affiliation: Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Arakawa
authors.affiliation: Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D001343:Autophagy / Q000187:drug effects / Q000502:physiology*; D002454:Cell Differentiation; D006706:Homeostasis; D006801:Humans; D008928:Mitochondria / Q000502:physiology*
keywords: Atg5-independent macroautophagy; Erythrocyte maturation; Mitophagy; Parkin; Selective autophagy