title: Luteal phase dynamics of follicle-stimulating and luteinizing hormones in obese and normal weight women.
abstract: OBJECTIVE
  Female obesity is a state of relative hypogonadotrophic hypogonadism. The aim of this study is to examine gonadotrophin secretion and response to gonadotrophin-releasing hormone (GnRH) in the luteal phase of the menstrual cycle and to investigate the pharmacodynamics and pharmacokinetics of endogenous and exogenous luteinizing hormone (LH) in obese women.
  
  
  METHODS
  Participants underwent a luteal phase frequent blood sampling study. Endogenous LH pulsatility was observed, gonadotrophin-releasing hormone (GnRH) was given in two weight-based doses, and GnRH antagonist was administered followed by recombinant LH.
  
  
  METHODS
  Regularly menstruating obese (n = 10) and normal weight (n = 10) women.
  
  
  METHODS
  Endogenous hypothalamic-pituitary function (as measured by LH pulsatility), pituitary sensitivity (GnRH-induced LH secretion), pharmacodynamics of endogenous LH and pharmacokinetics of exogenous LH were compared between the obese and normal weight groups.
  
  
  RESULTS
  There were no statistically significant differences in endogenous LH pulsatility or pituitary responses to two weight-based doses of GnRH between the obese and normal weight women. There were no differences in the pharmacodynamics of endogenous LH or the pharmacokinetics of exogenous LH between the groups. FSH dynamics did not differ between the groups throughout the study.
  
  
  CONCLUSIONS
  The relative hypogonadotrophic hypogonadism of obesity cannot be explained by differences in LH and FSH luteal phase dynamics or differences in endogenous LH pharmacodynamics or exogenous LH pharmacokinetics.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, University of Colorado, Denver, CO, USA.
authors.forename: Lauren W
authors.initials: LW
authors.lastname: Roth
authors.forename: Amanda A
authors.initials: AA
authors.lastname: Allshouse
authors.forename: Erica L
authors.initials: EL
authors.lastname: Bradshaw-Pierce
authors.forename: Jennifer
authors.initials: J
authors.lastname: Lesh
authors.forename: Justin
authors.initials: J
authors.lastname: Chosich
authors.forename: Wendy
authors.initials: W
authors.lastname: Kohrt
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Bradford
authors.forename: Alex J
authors.initials: AJ
authors.lastname: Polotsky
authors.forename: Nanette
authors.initials: N
authors.lastname: Santoro
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007006:Hypogonadism / Q000097:blood; D008183:Luteal Phase / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood*; D055815:Young Adult
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone