title: Recent advances in the ARID family: focusing on roles in human cancer.
abstract: The human AT-rich interaction domain (ARID) family contains seven subfamilies and 15 members characterized by having an ARID. Members of the ARID family have the ability to regulate transcription and are involved in cell differentiation and proliferation. Accumulating evidence suggests that ARID family members are involved in cancer-related signaling pathways, highly mutated or differentially expressed in tumor tissues, and act as predictive factors for cancer prognosis or therapeutic outcome. Here we review the molecular biology and clinical studies concerned with the role played by the ARID family in cancer. This may contribute to our understanding of the initiation and progression of cancer from a novel point of view, as well as providing potential targets for cancer therapy.
authors.affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Beijing, People's Republic of China.
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Song
authors.affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Beijing, People's Republic of China.
authors.forename: Xinyu
authors.initials: X
authors.lastname: Bi
authors.affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Beijing, People's Republic of China.
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Beijing, People's Republic of China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Huang
authors.affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Beijing, People's Republic of China.
authors.forename: Zhiyu
authors.initials: Z
authors.lastname: Li
authors.affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Beijing, People's Republic of China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhou
authors.affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Beijing, People's Republic of China.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Cai
authors.affiliation: Department of Abdominal Surgical Oncology, Cancer Hospital, Beijing, People's Republic of China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
keywords: AT-rich interaction domain; cancer-related signaling pathway; human cancer; potential targets; therapy