title: Does HBV infection increase risk of endometrial carcinoma?
abstract: OBJECTIVE
  Connections between chronic inflammation and tumor development and progression are now generally accepted. Recent evidence indicates that hepatitis B is associated with several types of cancer, but whether endometrial carcinoma (EC) is included has not been reported.
  
  
  METHODS
  We analyzed HBV serum marker status in 398 patients with endometrial cancer, comparing them to 788 control women undergoing health examination.
  
  
  RESULTS
  The total prevalence of HBsAg tested positive in cancer group was significantly higher than the control group (12.8% vs 6.0%, P=0.001), while positive HBsAb was significantly lower (41.2% vs 68.5%, P=0.001). Hepatitis B carriers in endometrial cancer group were also more frequent than in the control group (9.3% vs 5.5%, P=0.013). Interestingly, in the endometrial cancer group, 147 cases were HBV serum marker negative, which was also higher than in the control group (36.9% vs 15.6%, P=0.001).
  
  
  CONCLUSIONS
  There may be a correlation between HBV infection and endometrial carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, the First Affiliated Hospital, Jinan University, Guangzhou, China E-mail : xuefengjiang@126.com.
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Jiang
authors.forename: Qiong-Lan
authors.initials: QL
authors.lastname: Tang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zou
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Hua
authors.initials: H
authors.lastname: Zeng
authors.forename: Cong
authors.initials: C
authors.lastname: Chi
authors.forename: Jing-Ru
authors.initials: JR
authors.lastname: Jiang
authors.forename: Bin-Zhong
authors.initials: BZ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D016889:Endometrial Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000821:virology*; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000150:complications* / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens