title: Caged peptides to control enzymatic activity within hydrogel scaffolds.
abstract: Enzyme-assisted 3D lithography: A peptide substrate for transglutaminase factor XIII (FXIIIa) can be caged with a photo-deprotectable group and immobilized to the hydrogel framework. The substrate can be decaged by using multiphoton light to anchor cell-signaling motifs in a spatial specific manner.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022 (P. R. China). linyuan@ciac.jl.cn.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Lin
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000595:Amino Acid Sequence; D005176:Factor XIII / Q000378:metabolism*; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D055767:Immobilized Proteins / Q000737:chemistry / Q000378:metabolism; D008027:Light; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D017785:Photons
chemical_list: D055767:Immobilized Proteins; D010455:Peptides; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D005176:Factor XIII
keywords: cage compounds; cell signaling; hydrogels; peptides; photochemistry