title: Correlative study of squash smear cytology with histopathology in a rare case of anaplastic giant cell ependymoma of the pineal.
abstract: Anaplastic giant cell ependymoma (AGCE) is a very rare neoplasm. Its cytological features, helpful for the intraoperative diagnosis, have been reported only once. AGCE is characterized by giant cells with intranuclear inclusions, besides other findings, observable in ependymal neoplasms, such as intracytoplasmic vacuoles, epithelial and glial features of the tumor cells and ependymal pseudorosettes. These findings can be detected also in intraoperative squash smear. Herein we describe a pineal AGCE, highlighting the cytological and histological correlations and underlining some useful diagnostic clues of this unusual entity.
authors.affiliation: Department of Medicine, Surgery and Neuroscience, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte, Siena, Italy.
authors.forename: Marzia
authors.initials: M
authors.lastname: Toscano
authors.affiliation: Department of Medicine, Surgery and Neuroscience, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte, Siena, Italy.
authors.forename: Marie Aimée Gloria Munezero
authors.initials: MA
authors.lastname: Butorano
authors.affiliation: Department of Medicine, Surgery and Neuroscience, Unit NINT Neuro-imaging and Neuro-intervention, Policlinico Santa Maria alle Scotte, Siena, Italy.
authors.forename: Alfonso
authors.initials: A
authors.lastname: Cerase
authors.affiliation: Department of Medicine, Surgery and Neuroscience, Section of Pathological Anatomy, Policlinico Santa Maria alle Scotte, Siena, Italy. miracco@unisi.it.
authors.forename: Clelia
authors.initials: C
authors.lastname: Miracco
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D003581:Cytodiagnosis / Q000379:methods*; D004806:Ependymoma / Q000473:pathology*; D005870:Giant Cell Tumors / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010871:Pinealoma / Q000473:pathology*; D013048:Specimen Handling / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor