title: Delayed-enhancement magnetic resonance imaging at 3.0T using 0.15mmol/kg of contrast agent for the assessment of chronic myocardial infarction.
abstract: OBJECTIVE
  A recent international, multicenter, double-blinded, randomized trial shows delayed-enhanced magnetic resonance imaging (DE-MRI) using contrast doses of ≥0.2mmol/kg is effective in the detection and assessment of myocardial infarction (MI), and 0.1mmol/kg is not enough; intermediate doses between 0.1 and 0.2mmol/kg have not been tested. The aim of this study was to prospectively test the performance of DE-MRI using 0.15mmol/kg of contrast agent for the detection of MI.
  
  
  METHODS
  A total of 31 consecutive patients with chronic MI underwent DE-MRI at 3.0T using both 0.15mmol/kg and 0.2mmol/kg of contrast agent in random order and on separate days. Infarction segment and infarction size were compared on DE-MRI images using a 17-segment model. Bland-Altman analysis was used to analyze correlation and agreement between global infarct sizes.
  
  
  RESULTS
  DE-MRI showed enhanced myocardium in all the 31 patients with chronic MI. There was no significant difference between the 0.15mmol/kg and 0.2mmol/kg images in all 31 patients based on the infarction segment (7.87±2.72 vs. 7.81±2.64, respectively; p=0.33). There was no significant difference between the infarction size obtained from 0.15mmol/kg acquisition and that from 0.2mmol/kg acquisition (16.3±7.8% vs. 16.4±7.9%, respectively; p=0.87). A strong correlation between the infarction size obtained from 0.15mmol/kg acquisition and that from 0.2mmol/kg acquisition was indicated through Bland-Altman analysis.
  
  
  CONCLUSIONS
  DE-MRI at 3.0T using 0.15mmol/kg of contrast agent is effective for the assessment of MI.
authors.affiliation: Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: yangjunyhd@163.com.
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.affiliation: Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: mahengyhd@163.com.
authors.forename: Heng
authors.initials: H
authors.lastname: Ma
authors.affiliation: Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: liujingyhd@163.com.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.affiliation: Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: chunxiaoyhd@163.com.
authors.forename: Chunxiao
authors.initials: C
authors.lastname: Wang
authors.affiliation: Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: yinghongyhd@163.com.
authors.forename: Yinghong
authors.initials: Y
authors.lastname: Shi
authors.affiliation: Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: haizhuyhd@163.com.
authors.forename: Haizhu
authors.initials: H
authors.lastname: Xie
authors.affiliation: Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: kailinusa@126.com.
authors.forename: Futao
authors.initials: F
authors.lastname: Huo
authors.affiliation: Yuhuangding Hospital, Yantai, Shandong Province, China. Electronic address: fengliyhd@126.com.
authors.forename: Fengli
authors.initials: F
authors.lastname: Liu
authors.affiliation: Department of Radiology, Northwestern University, Chicago, IL, USA. Electronic address: kai-lin@northwestern.edu.
authors.forename: Kai
authors.initials: K
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D003287:Contrast Media / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000473:pathology*; D015588:Observer Variation; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000473:pathology*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA
keywords: Imaging; Magnetic resonance imaging; Myocardial infarction