title: Antiangiogenic activity of hypoxylonol C.
abstract: Hypoxylonol C (1), isolated from the inedible mushroom Hypoxylon truncatum, exhibited inhibitory activities against the migration and tube formation of HUVECs. A cDNA microarray analysis was performed to investigate the target of hypoxylonol C (1) in HUVECs, and it was found that the genes related to cell cycle and adhesion were down-regulated. The down-regulation of mRNA levels of cell cycle and adhesion genes was confirmed by real-time RT-PCR. Cell cycle arrest and suppression of adhesion molecule expression might be plausible mechanisms of actions for the antiangiogenic activity of hypoxylonol C (1).
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University , Noshio 2-522-1 Kiyose-shi, Tokyo 204-8588, Japan.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Fukai
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Ikuko
authors.initials: I
authors.lastname: Nagasawa
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Kunio
authors.initials: K
authors.lastname: Takahashi
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Koyama
mesh_terms: D020533:Angiogenesis Inhibitors / Q000235:genetics / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005449:Fluorenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D042461:Vascular Endothelial Growth Factor A / Q000494:pharmacology
chemical_list: D020533:Angiogenesis Inhibitors; D005449:Fluorenes; D042461:Vascular Endothelial Growth Factor A; C000589915:hypoxylonol C