title: Neuropathology of the posteroinferior occipitotemporal gyrus in children with autism.
abstract: BACKGROUND
  While most neuropathologic studies focus on regions involved in behavioral abnormalities in autism, it is also important to identify whether areas that appear functionally normal are devoid of pathologic alterations. In this study we analyzed the posteroinferior occipitotemporal gyrus, an extrastriate area not considered to be affected in autism. This area borders the fusiform gyrus, which is known to exhibit functional and cellular abnormalities in autism.
  
  
  RESULTS
  No studies have implicated posteroinferior occipitotemporal gyrus dysfunction in autism, leading us to hypothesize that neuropathology would not occur in this area. We indeed observed no significant differences in pyramidal neuron number or size in layers III, V, and VI in seven pairs of autism and controls.
  
  
  CONCLUSIONS
  These findings are consistent with the hypothesis that neuropathology is unique to areas involved in stereotypies and social and emotional behaviors, and support the specificity of the localization of pathology in the fusiform gyrus.
authors.forename: Neha
authors.initials: N
authors.lastname: Uppal
authors.forename: Isabella
authors.initials: I
authors.lastname: Gianatiempo
authors.forename: Bridget
authors.initials: B
authors.lastname: Wicinski
authors.forename: James
authors.initials: J
authors.lastname: Schmeidler
authors.forename: Helmut
authors.initials: H
authors.lastname: Heinsen
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmitz
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Buxbaum
authors.affiliation: Fishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, One Gustave L Levy Place, Box 1639, New York, NY 10029, USA. patrick.hof@mssm.edu.
authors.forename: Patrick R
authors.initials: PR
authors.lastname: Hof