title: Activity of disinfectants against multispecies biofilms formed by Staphylococcus aureus, Candida albicans and Pseudomonas aeruginosa.
abstract: Microbial biofilms are a serious threat to human health. Recent studies have indicated that many clinically relevant biofilms are polymicrobial. In the present study, multispecies biofilms were grown in a reproducible manner in a 96-well microtiter plate. The efficacy of nine commercially available disinfectants against Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa in multispecies biofilms was determined and compared. The results showed that the direction and the magnitude of the effect in a multispecies biofilm depend on the strain and the disinfectant used and challenge the common belief that organisms in multispecies biofilms are always less susceptible than in monospecies biofilms.
authors.affiliation: a Laboratory of Pharmaceutical Microbiology , Ghent University , Ghent , Belgium.
authors.forename: Didem
authors.initials: D
authors.lastname: Kart
authors.forename: Sarah
authors.initials: S
authors.lastname: Tavernier
authors.forename: Heleen
authors.initials: H
authors.lastname: Van Acker
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Nelis
authors.forename: Tom
authors.initials: T
authors.lastname: Coenye
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D057219:Biofouling / Q000517:prevention & control; D002176:Candida albicans / Q000187:drug effects / Q000502:physiology; D004202:Disinfectants / Q000494:pharmacology*; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D018384:Oxidative Stress; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology
chemical_list: D004202:Disinfectants; D017382:Reactive Oxygen Species