title: [Association of leptin gene-2548 G/A polymorphism with obesity: a meta-analysis].
abstract: OBJECTIVE
  To examine the association between a common single nucleotide polymorphism identified in the 5' untranslated region of leptin gene (LEP-2548 G/A SNP) and obesity.
  
  
  METHODS
  Meta-analysis of published studies, included if subjects were genotyped at polymorphism LEP-2548 G/A and both obese and nonobese subjects were selected, based on a reported cutoff BMI limit. Meta-analysis of the total and subgroup populations was conducted using dominant and recessive models, and OR and 95% CI were calculated in the fixed-effect model. I2 statistic was calculated to examine heterogeneity, and publication bias was evaluated by Egger test.
  
  
  RESULTS
  After testing each control group for Hardy-Woinberg equilibrium, the final selection enrolled 11 studies, including 5210 subjects (2541 obesity subjects and 2669 healthy). In the combined analysis of all eligible studies, none significant association was identified between LEP-2548 G/A SNP and obesity either in dominant model or the recessive one with pooled odds ratios 1.14 (95% CI 0.98-1.31, P = 0.08) and 1.03 (95% CI 0.85-1.25, P = 0.76). However, subgroup analysis found a significant association of GG homozygote in American population [OR = 1.53 (95% CI 1.17-2.00), P = 0.002]. No significant evidence was found in other populations.
  
  
  CONCLUSIONS
  This first metaanalysis of data from published studies did not detect any association between the polymorphism of LEP-2548 G/A and risk of obesity in overall population. Nevertheless, the presence of the GG genotype in the gene appears to be a significant risk factor for obesity in American.
authors.affiliation: Department of Nutrition and Food Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China. zhangling8107@126.com
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.affiliation: Department of Nutrition and Food Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Mingyang
authors.initials: M
authors.lastname: Lu
authors.affiliation: Department of Nutrition and Food Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Linhong
authors.initials: L
authors.lastname: Yuan
authors.affiliation: Department of Nutrition and Food Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Weiqi
authors.initials: W
authors.lastname: Lai
authors.affiliation: Department of Nutrition and Food Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China.
authors.forename: Yin
authors.initials: Y
authors.lastname: Wang
mesh_terms: D005838:Genotype; D006801:Humans; D020738:Leptin / Q000235:genetics*; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D016032:Randomized Controlled Trials as Topic
chemical_list: D020738:Leptin