title: Platelet activation by riboflavin and UV light: is it really the other side of the coin?
abstract: BACKGROUND
  Nowadays transfusion safety is still put at risk by contamination of pathogens. The Mirasol PRT System blocks the replication of pathogens and white blood cells. Our goal was to quantify the activation of platelets after treatment with the Mirasol device.
  
  
  METHODS
  From September to December 2013, 131 platelet collections were studied using a simple flow cytometric strategy.
  
  
  RESULTS
  There was a significant correlation between the percentage of platelet activated before and after the treatment.
  
  
  CONCLUSIONS
  Our results induced us to think that the activation of platelets after treatment was acceptable.
authors.affiliation: SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: delpropostog@gmail.com.
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Del Proposto
authors.affiliation: SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: ale.lanti@libero.it.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lanti
authors.affiliation: Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: elefiorelli@hotmail.it.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Fiorelli
authors.affiliation: Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: gloriapalazzo3010@gmail.com.
authors.forename: Gloria
authors.initials: G
authors.lastname: Palazzo
authors.affiliation: Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: giorgiaguiducci@yahoo.it.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Guiducci
authors.affiliation: SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: messinafrancesca@virgilio.it.
authors.forename: Francesca
authors.initials: F
authors.lastname: Messina
authors.affiliation: Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: demasialessandra@gmail.com.
authors.forename: Alessandra
authors.initials: A
authors.lastname: De Masi
authors.affiliation: SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: angelosalvatore.ferraro@gmail.com.
authors.forename: Angelo Salvatore
authors.initials: AS
authors.lastname: Ferraro
authors.affiliation: Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: oanaafl@gmail.com.
authors.forename: Oana Marilena
authors.initials: OM
authors.lastname: Chiru
authors.affiliation: SIMT Tor Vergata Hospital, Rome, Italy. Electronic address: laugiu9799@libero.it.
authors.forename: Paola
authors.initials: P
authors.lastname: Cerrone
authors.affiliation: Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: magda.antonelli@libero.it.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Antonelli
authors.affiliation: SIMT Tor Vergata Hospital, Rome, Italy; Immunohematology Section, Tor Vergata University, Rome, Italy. Electronic address: medtras@libero.it.
authors.forename: Gaspare
authors.initials: G
authors.lastname: Adorno
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000166:cytology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017319:Photosensitizing Agents / Q000494:pharmacology*; D015539:Platelet Activation / Q000187:drug effects / Q000528:radiation effects; D012256:Riboflavin / Q000494:pharmacology*; D014466:Ultraviolet Rays
chemical_list: D017319:Photosensitizing Agents; D012256:Riboflavin
keywords: Annexin V; Glycoproteins IIb/IIIa; Platelet collections; Riboflavin; UV light