title: Moderate chronic administration of Vineatrol-enriched red wines improves metabolic, oxidative, and inflammatory markers in hamsters fed a high-fat diet.
abstract: METHODS
  High-fat (HF) diets contribute to the development of cardiovascular diseases and the metabolic syndrome. This study was undertaken to investigate the beneficial effects of Vineatrol®-enriched red wines on blood lipids, oxidative stress and inflammation, and the role of some metabolic pathway regulatory proteins.
  
  
  RESULTS
  Golden Syrian hamsters received an HF diet for 13 wk, in the presence or absence of red wines supplemented with Vineatrol® (RWV) or not. The HF diet increased plasma cholesterol, triglycerides, glucose, and insulin, which were attenuated by RWV treatment. RWV protected against the HF-induced increase in liver nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity and spared antioxidant enzyme activities. RWV did not reduce either liver steatosis or increased plasma leptin due to the HF diet, but greatly improved adiponectinemia. In the liver, RWV affected the inflammatory response by decreasing polymorphonuclear cell number and lowering TNF-α and IL-6 levels. Moreover, the increase in NF-κB activity in the HF group liver was prevented by RWV. Finally, RWV partially corrected low SIRT1 levels due to the HF diet but had no influence on SIRT3 or p-AMPK protein levels.
  
  
  CONCLUSIONS
  Our studies suggest that RWV is capable of reversing the atherogenic process induced by an HF diet in hamster tissues.
authors.affiliation: Nutrition & Metabolism, UMR 204 NUTRIPASS, Prevention of Malnutritions & Linked Pathologies, University Montpellier South of France, Place Eugène Bataillon, Montpellier, France.
authors.forename: Cindy
authors.initials: C
authors.lastname: Romain
authors.forename: Letizia
authors.initials: L
authors.lastname: Bresciani
authors.forename: Sylvie
authors.initials: S
authors.lastname: Gaillet
authors.forename: Christine
authors.initials: C
authors.lastname: Feillet-Coudray
authors.forename: Luca
authors.initials: L
authors.lastname: Calani
authors.forename: Béatrice
authors.initials: B
authors.lastname: Bonafos
authors.forename: Joris
authors.initials: J
authors.lastname: Vidé
authors.forename: Nathalie
authors.initials: N
authors.lastname: Rugani
authors.forename: Jeanne
authors.initials: J
authors.lastname: Ramos
authors.forename: Daniele
authors.initials: D
authors.lastname: Del Rio
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Cristol
authors.forename: Jean-Max
authors.initials: JM
authors.lastname: Rouanet
mesh_terms: D052242:Adiponectin / Q000097:blood; D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000209:etiology; D015415:Biomarkers / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D006224:Cricetinae; D059305:Diet, High-Fat / Q000009:adverse effects*; D019587:Dietary Supplements; D005234:Fatty Liver / Q000188:drug therapy; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D020738:Leptin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008647:Mesocricetus; D024821:Metabolic Syndrome / Q000188:drug therapy*; D019255:NADPH Oxidases / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology*; D056564:Sirtuin 1 / Q000097:blood; D056566:Sirtuin 3 / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014920:Wine / Q000032:analysis*
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D015850:Interleukin-6; D020738:Leptin; D016328:NF-kappa B; D010636:Phenols; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; C509818:vineatrol; D002784:Cholesterol; D019255:NADPH Oxidases; D056564:Sirtuin 1; D056566:Sirtuin 3
keywords: Atherosclerosis; Liver inflammation; Oxidative stress; Stilbene-rich wines; Vineatrol 30®