title: Effects of treadmill training on combined goserelin acetate and doxorubicin-induced osteopenia in female rats.
abstract: OBJECTIVE
  This study examined individual and combined effects of the cancer treatments goserelin acetate (GA) and doxorubicin (DOX) on bone and determined if treadmill running (TM) provides osteoprotection.
  
  
  METHODS
  Ten-week-old female Sprague-Dawley rats were randomly assigned to sedentary (SED) or TM groups. SED received GA, DOX, combined GA and DOX (GA+DOX), or placebo and maintained normal cage activity. TM received GA, DOX, GA+DOX, or placebo and participated in a progressive motorized treadmill protocol. After 8 weeks, tibiae were evaluated using micro computed tomography.
  
  
  RESULTS
  Negative drug effects were observed in cancellous bone (bone volume/tissue volume, trabecular number, trabecular thickness, trabecular spacing; P<0.05). An additive bone volume/tissue volume and trabecular spacing effect was observed in SED GA+DOX (vs. SED+GA and SED+DOX, P<0.05) but not in TM GA+DOX (vs. TM+GA and TM+DOX, P>0.05). Negative drug effects were observed in cortical bone (cross-sectional volume, cortical volume, marrow volume; P<0.05), but combined GA+DOX did not exacerbate these effects. Additionally, there were no protective cortical bone effects observed in TM.
  
  
  CONCLUSIONS
  Combined GA+DOX exacerbates cancellous osteopenia in the tibia, and treadmill running provided only minor protection.
authors.affiliation: School of Sport and Exercise Science and the Rocky Mountain Cancer Rehabilitation Institute, University of Northern Colorado, Greeley, CO.
authors.forename: D S
authors.initials: DS
authors.lastname: Hydock
authors.forename: T L
authors.initials: TL
authors.lastname: Parry
authors.forename: J D
authors.initials: JD
authors.lastname: Wymore
authors.forename: U T
authors.initials: UT
authors.lastname: Iwaniec
authors.forename: R T
authors.initials: RT
authors.lastname: Turner
authors.forename: C M
authors.initials: CM
authors.lastname: Schneider
authors.forename: R
authors.initials: R
authors.lastname: Hayward
mesh_terms: D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001851:Bone Diseases, Metabolic / Q000139:chemically induced / Q000534:rehabilitation*; D004317:Doxorubicin / Q000009:adverse effects*; D005260:Female; D017273:Goserelin / Q000009:adverse effects*; D010805:Physical Conditioning, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin; D004317:Doxorubicin