title: [Eye and systemic manifestations of Mobius syndrome].
abstract: BACKGROUND
  Mobius syndrome is characterized by damage in the nucleus of the sixth and seventh cranial nerves, with subsequent facial palsy and abduction limitation of the eyes. The aim of this article is to describe the ophthalmological findings of the Mobius syndrome in Mexican children.
  
  
  METHODS
  A cross-sectional, retrospective, observational and descriptive study was conducted. A review was made of the clinical charts of patients with Mobius syndrome who were seen in the National Institute of Pediatrics in Mexico, between the years 2000 and 2010.
  
  
  RESULTS
  A total of 64 charts were reviewed. The most important findings were eye abduction limitation (100%), facial palsy (100%), esotropia (54%), epicanthus (51.5%), entropion (22%), and history of use of abortion inducers in the mother in the first trimester of pregnancy (28%). We also found exotropia and hypertropia in some cases.
  
  
  CONCLUSIONS
  Mobius syndrome has a wide spectrum of ophthalmological manifestations that are important to detect early in order to improve function and esthetics.
authors.affiliation: Servicio de Oftalmología Pediátrica, Instituto Nacional de Pediatría, México Distrito Federal, México. Electronic address: ambp09@gmail.com.
authors.forename: A M
authors.initials: AM
authors.lastname: Borbolla Pertierra
authors.affiliation: Servicio de Oftalmología Pediátrica, Instituto Nacional de Pediatría, México Distrito Federal, México.
authors.forename: P
authors.initials: P
authors.lastname: Acevedo González
authors.affiliation: Servicio de Oftalmología Pediátrica, Instituto Nacional de Pediatría, México Distrito Federal, México.
authors.forename: V
authors.initials: V
authors.lastname: Bosch Canto
authors.affiliation: Servicio de Oftalmología Pediátrica, Instituto Nacional de Pediatría, México Distrito Federal, México.
authors.forename: J C
authors.initials: JC
authors.lastname: Ordaz Favila
authors.affiliation: Servicio de Oftalmología Pediátrica, Instituto Nacional de Pediatría, México Distrito Federal, México.
authors.forename: J C
authors.initials: JC
authors.lastname: Juárez Echenique
mesh_terms: D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005128:Eye Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D020331:Mobius Syndrome / Q000150:complications* / Q000175:diagnosis*; D012189:Retrospective Studies
keywords: Abortion inducing Agents; Agentes abortivos; Endotropia; Entropion; Entropión; Epicanthus; Epicanto; Esotropia; Facial palsy; Mobius Syndrome; Parálisis facial; Síndrome de Möebius