title: Depression-related differences in lean body mass distribution from National Health and Nutrition Examination Survey 2005-2006.
abstract: BACKGROUND
  Although the association between depression and body composition has been widely discussed, the effects of depression on lean body mass (LBM) are unclear. The present study aimed to investigate the association of depression with LBM.
  
  
  METHODS
  The study included 2406 participants aged 18-69 years. The sex and body mass index (BMI) stratified analysis of covariance was performed to compare total LBM and percentage LBM (%LBM) in subjects with different depression score levels. Multiple linear regression analysis was conducted to estimate the association between depression score and serum albumin level.
  
  
  RESULTS
  An analysis of covariance stratified by sex showed that participants with moderate-to-severe depression had significantly decreased total LBM and total and regional %LBM in men, except for total LBM and percentage gynoid LBM, which was observed in women. In the BMI stratified analysis of covariance, depression was significantly associated with decreased total and regional %LBM and with increased total and regional percentage fat body mass. In people with BMI≥25kg/m(2), the associations between depression or depressive syndrome and LBM, and total and regional %LBM are stronger compared to those with BMI<25kg/m(2). Multiple linear regression analysis showed that depression score was significantly negatively associated with serum albumin level.
  
  
  CONCLUSIONS
  This is a cross-sectional study based on a general population, some information about clinical diagnosis and medication use is not available.
  
  
  CONCLUSIONS
  Depression had a significant negative association with LBM and serum albumin level.
authors.affiliation: Department of Social Medicine, School of Public Health, Zhejiang University, China. Electronic address: ying_li@zju.edu.cn.
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Social Medicine, School of Public Health, Zhejiang University, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Meng
authors.affiliation: Department of Clinical Medicine, School of Medicine, Zhejiang University, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Li
authors.affiliation: Department of Hygiene and Public Health II, Tokyo Women's Medical University, Japan.
authors.forename: Yasuto
authors.initials: Y
authors.lastname: Sato
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D001823:Body Composition; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003863:Depression / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009749:Nutrition Surveys; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism*; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D012709:Serum Albumin
keywords: Body composition; Cross-sectional study; Depression; Depressive symptoms; Dual energy X-ray absorptiometry; Serum albumin