title: Facile stripping voltammetric determination of haloperidol using a high performance magnetite/carbon nanotube paste electrode in pharmaceutical and biological samples.
abstract: Multi-walled carbon nanotubes decorated with Fe3O4 nanoparticles were prepared to construct a novel sensor for the determination of haloperidol (Hp) by voltammetric methods. The morphology and properties of electrode surface were characterized by scanning electron microscopy (SEM) and electrochemical impedance spectroscopy. This modified sensor was used as a selective electrochemical sensor for the determination of trace amounts of Hp. The peak currents of differential pulse and square wave voltammograms of Hp increased linearly with its concentration in the ranges of 1.2×10(-3)-0.52 and 6.5×10(-4)-0.52μmol L(-1), respectively. The detection limits for Hp were 7.02×10(-4) and 1.33×10(-4)μmol L(-1) for differential pulse and square wave voltammetric methods, respectively. The results show that the combination of multi-walled carbon nanotubes and Fe3O4 nanoparticles causes a dramatic enhancement in the sensitivity of Hp quantification. This sensor was successfully applied to determine Hp in pharmaceutical samples and biological fluids. The fabricated electrode showed excellent reproducibility, repeatability and stability.
authors.affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: h.bagheri@srbiau.ac.ir.
authors.forename: Hasan
authors.initials: H
authors.lastname: Bagheri
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
authors.forename: Abbas
authors.initials: A
authors.lastname: Afkhami
authors.affiliation: Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Yunes
authors.initials: Y
authors.lastname: Panahi
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
authors.forename: Hosein
authors.initials: H
authors.lastname: Khoshsafar
authors.affiliation: Faculty of Chemistry, Bu-Ali Sina University, Hamedan, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Shirzadmehr
mesh_terms: D055664:Electrochemical Techniques; D004566:Electrodes; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006220:Haloperidol / Q000032:analysis* / Q000097:blood; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D013499:Surface Properties; D013607:Tablets / Q000737:chemistry
chemical_list: D037742:Nanotubes, Carbon; D013607:Tablets; D006220:Haloperidol; D052203:Ferrosoferric Oxide
keywords: Carbon paste electrodes; Electrochemical sensor; Haloperidol; Magnetic multi-walled carbon nanotubes; Multi-walled carbon nanotubes; Voltammetry