title: Boron trifluoride etherate functioning as a fluorine source in an iodosobenzene-mediated intramolecular aminofluorination of homoallylic amines.
abstract: A widely used Lewis acid BF3·Et2O was shown to be capable of acting as an efficient fluorinating agent in an intramolecular aminofluorination reaction of homoallylic amines to provide 3-fluoropyrrolidines mediated by a commercially available hypervalent iodine(III) reagent PhIO at room temperature. A mechanism involving a carbocation intermediate was proposed on the basis of several experimental evidence.
authors.affiliation: State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), The Research Institute of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, P. R. of China.
authors.forename: Jian
authors.initials: J
authors.lastname: Cui
authors.forename: Qun
authors.initials: Q
authors.lastname: Jia
authors.forename: Ruo-Zhu
authors.initials: RZ
authors.lastname: Feng
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Liu
authors.forename: Tian
authors.initials: T
authors.lastname: He
authors.forename: Chi
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000588:Amines / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D005461:Fluorine / Q000737:chemistry*; D007462:Iodobenzenes / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D001880:Boranes; D007462:Iodobenzenes; D058116:Lewis Acids; D011759:Pyrrolidines; D005461:Fluorine; C101707:boron trifluoride etherate; C037276:iodosobenzene