title: Serum amyloid A and Omentin levels in acute appendicitis: a preliminary study for a novel diagnostic approach.
abstract: BACKGROUND
  The diagnosis of acute appendicitis is based on medical history and physical examination. Serum (S) amiloid A (AA) levels are elevated in many inflammatory conditions. Omentin is a recently discovered adipokine showing decreased levels associated with inflammatory conditions. We aimed to measure SAA and omentin levels in patients with acute appendicitis.
  
  
  METHODS
  36 patients with a diagnosis of acute appendicitis and 30 healthy subjects were enrolled to this research study. A statistical analysis was performed using IBM SPSS Statistics Version 16.0 (SPSS Inc.®, Chicago, IL, United States).
  
  
  RESULTS
  Patients in study group were significantly older than healthy control subjects (p=0.013). Body mass index of the patients with acute appendicitis (23.2 ± 1.3) was greater than that of the control group (22.7 ± 1), but the difference did not reach the statistically significance (p=0.076). ). Mean level of SAA was significantly raised in study group compared to healthy control subjects (p< 0.001). Mean omentin level was significantly lower in study group compared to healthy subjects (p=0.013).
  
  
  CONCLUSIONS
  In conclusion, although diagnosis of acute appendicitis is mostly based on clinical findings, omentin and especially SAA measurement in serum may help surgeons to avoid negative laparatomy.
authors.affiliation: Departments of General Surgery, Abant Izzet Baysal University Hospital, Bolu.
authors.forename: M
authors.initials: M
authors.lastname: Sit
authors.affiliation: Department of General Surgery, Ardahan State Hospital, Ardahan, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Catal
authors.affiliation: Departments of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu.
authors.forename: G
authors.initials: G
authors.lastname: Aktas
authors.affiliation: Departments of General Surgery, Abant Izzet Baysal University Hospital, Bolu.
authors.forename: E E
authors.initials: EE
authors.lastname: Yilmaz
authors.affiliation: Departments of Biochemistry, Abant Izzet Baysal University Hospital, Bolu.
authors.forename: M
authors.initials: M
authors.lastname: Tosun
authors.affiliation: Departments of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu.
authors.forename: H
authors.initials: H
authors.lastname: Savli
mesh_terms: D000208:Acute Disease; D000328:Adult; D001064:Appendicitis / Q000097:blood* / Q000175:diagnosis; D016207:Cytokines / Q000097:blood*; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D000685:Serum Amyloid A Protein / Q000378:metabolism*
chemical_list: D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins; D000685:Serum Amyloid A Protein