title: Association of coronary artery calcification with MDA-LDL-C/LDL-C and urinary 8-isoprostane in Japanese patients with type 2 diabetes.
abstract: OBJECTIVE
  Oxidative stress has been implicated in the development of coronary artery calcification (CAC). However, there are few reports on this issue in Japanese patients with diabetes. In this study, we examined the association of the CAC score (CACS) with oxidative stress markers.
  
  
  METHODS
  The study subjects were 163 Japanese patients with type 2 diabetes (75 men and 88 women). The CACS (Agatston unit: AU) was measured by multi-detector computed tomography (MDCT), and the oxidative stress markers, such as the urinary 8-isoprostane and 8-hydroxydeoxyguanosine (8-OHdG) and serum malondialdehyde (MDA)-LDL cholesterol were measured. The relationships between CACS and oxidative stress markers were statistically analyzed.
  
  
  RESULTS
  Compared with the CACS 0-400 AU group (n=132), the age, duration of diabetes, urinary 8-isoprostane levels, serum MDA-LDL-C/LDL-C and maximum intima media thickness (IMT) were higher, and body mass index and HbA1c level were lower, in the CACS >400 AU group (n=31). The multiple logistic regression analysis showed that a CAC >400 AU was independently associated with the urinary 8-isoprostane (>median) (OR=2.54, 95% CI=1.03-6.32, p=0.044), MDA-LDL-C/LDL-C (>median) (OR=2.62, 95% CI=1.07-6.40, p=0.035) and HbA1c (>median) (OR=0.32, CI=0.12-0.87, p<0.025). Focusing on oxidative stress, a higher MDA-LDL-C/LDL-C (p=0.026) and a higher urinary 8-isoprostane level (p=0.074) were associated with the CACS.
  
  
  CONCLUSIONS
  The CACS was found to be independently associated with the MDA-LDL-C/LDL-C and urinary 8-isoprostane levels in Japanese patients with type 2 diabetes.
authors.affiliation: Division of Diabetes and Metabolism, Department of Internal Medicine, Iwate Medical University School of Medicine, Japan.
authors.forename: Mitsutaka
authors.initials: M
authors.lastname: Ono
authors.forename: Noriko
authors.initials: N
authors.lastname: Takebe
authors.forename: Tomoyasu
authors.initials: T
authors.lastname: Oda
authors.forename: Riyuki
authors.initials: R
authors.lastname: Nakagawa
authors.forename: Mizue
authors.initials: M
authors.lastname: Matsui
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Sasai
authors.forename: Kan
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Honma
authors.forename: Takashi
authors.initials: T
authors.lastname: Kajiwara
authors.forename: Haruhito
authors.initials: H
authors.lastname: Taneichi
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Kazuma
authors.initials: K
authors.lastname: Takahashi
authors.forename: Jo
authors.initials: J
authors.lastname: Satoh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002114:Calcinosis / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D059168:Carotid Intima-Media Thickness; D008078:Cholesterol, LDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology / Q000378:metabolism*; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D061330:Multidetector Computed Tomography; D018384:Oxidative Stress; D015995:Prevalence; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; C075750:8-epi-prostaglandin F2alpha; D008315:Malondialdehyde; D015237:Dinoprost