title: Experimental murine acremoniosis: an emerging opportunistic human infection.
abstract: Acremonium is an emerging fungal pathogen causing severe infections. We evaluated the virulence of three clinically relevant species within the genus, i.e., Acremonium kiliense (currently Sarocladium kiliense), Acremonium sclerotigenum-A. egyptiacum complex and Acremonium implicatum in a murine model of disseminated infection. Both immunocompetent and immunosuppresssed mice were infected with two inocula concentrations (2 × 10(6) and 2 × 10(8) conidia/animal) of two strains of each species. Tissue burden, mortality rate, histopathology and levels of (1→3)-β-D-glucan were used as virulence markers. None of the species of Acremonium tested was able to cause infection in immunocompetent mice. Conversely, severe infections were produced in immunocompromised mice, the spleen being the most affected organ. In general, the virulence of the Acremonium species tested was low, S. kiliense being the most virulent species.
authors.affiliation: Unitat d'Anatomia Patològica, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Fabiola
authors.initials: F
authors.lastname: Fernández-Silva
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.forename: Deanna
authors.initials: D
authors.lastname: Sutton
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000164:Acremonium / Q000472:pathogenicity*; D000825:Animal Structures / Q000382:microbiology / Q000473:pathology; D000818:Animals; D015169:Colony Count, Microbial; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D004195:Disease Models, Animal; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D051379:Mice; D008853:Microscopy; D009181:Mycoses / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology*; D009894:Opportunistic Infections / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D011509:Proteoglycans; D016019:Survival Analysis; D014774:Virulence; D047071:beta-Glucans / Q000097:blood
chemical_list: D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K
keywords: Acremonium; fungal infection; immunosuppressed mice; mycosis; virulence