title: Lack of association of IRF5 gene polymorphisms with autoimmune thyroid disease: a case-control study. IRF5 gene and AITD.
abstract: BACKGROUND
  Several studies support a link between autoimmunity and interferon regulatory factor 5 (IRF5) gene polymorphisms. We have taken the opportunity to examine association of the autoimmune disease risk gene, the interferon regulatory factor 5 (IRF5) to survey its susceptibility to autoimmune thyroid disease. "A total of 667 patients with autoimmune thyroid diseases and 301 healthy controls were genotyped for rs10954213, rs2004640, rs3807306, rs752637 and rs7808907 of IRF5 gene polymorphisms". We further investigated the association between BANK1 gene and IRF5 gene in AITD patients.
  
  
  RESULTS
  For IRF5 gene, both in allele and genotype frequencies from both GD and HT patients were not significantly different from those of controls. Association between rs7808907C allele and Graves' disease showed trend towards significance (P=0.067). Haplotype results in IRF5 represented in the same block, without significant association. No significant association was found between all IRF5 SNPs and ophthalmopathy in Graves' patients. Additive interaction analysis revealed no interactions between IRF5 and BANK1 gene in AITD patients.
  
  
  CONCLUSIONS
  Our data fail to reveal IRF5 as a susceptibility gene to AITD and do not support additive effect of IRF5 to BANK1 gene.
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Medical School of Xi'an Jiaotong University, No. 277 West Yanta Road, 710061 Xi'an, China; Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Fatuma-Said
authors.initials: FS
authors.lastname: Muhali
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Medical School of Xi'an Jiaotong University, No. 277 West Yanta Road, 710061 Xi'an, China; Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhou-jiao
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Medical School of Xi'an Jiaotong University, No. 277 West Yanta Road, 710061 Xi'an, China; Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, The First Affiliated Hospital of Medical School of Xi'an Jiaotong University, No. 277 West Yanta Road, 710061 Xi'an, China; Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Shi
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Wen-juan
authors.initials: WJ
authors.lastname: Jiang
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xiao
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Dan-feng
authors.initials: DF
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Shuang-tao
authors.initials: ST
authors.lastname: He
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Xu
authors.affiliation: Department of Endocrinology, Jinshan Hospital of Fudan University, No. 1508 Longhang Road, 201508 Shanghai, China. Electronic address: zhangjinan@hotmail.com.
authors.forename: Jin-an
authors.initials: JA
authors.lastname: Zhang
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004843:Epistasis, Genetic; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006111:Graves Disease / Q000453:epidemiology / Q000235:genetics*; D049970:Graves Ophthalmopathy / Q000235:genetics; D006239:Haplotypes; D050031:Hashimoto Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics*; D015810:Linkage Disequilibrium; D008297:Male; D008565:Membrane Proteins / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C447641:BANK1 protein, human; C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors; D008565:Membrane Proteins