title: Direct N9-arylation of purines with aryl halides.
abstract: An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N(9)-position.
authors.affiliation: Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark. ulven@sdu.dk.
authors.forename: Anders Foller
authors.initials: AF
authors.lastname: Larsen
authors.forename: Trond
authors.initials: T
authors.lastname: Ulven
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D010618:Phenanthrolines / Q000737:chemistry; D011687:Purines / Q000737:chemistry*
chemical_list: D006846:Hydrocarbons, Halogenated; D010618:Phenanthrolines; D011687:Purines; D003300:Copper; C025205:1,10-phenanthroline; C030985:purine