title: Serum and urinary NGAL in septic newborns.
abstract: Neutrophil gelatinase-associated lipocalin (NGAL) is postulated to be a potentially new and highly specific/sensitive marker of acute kidney injury (AKI). The aim of this study was to assess the impact of inflammation on serum and urine NGAL in newborns that were treated due to infection. We determined serum and urine NGAL concentrations in 73 infants (51 with sepsis; 22 with severe sepsis) admitted to the Intensive Care Unit in the first month of life, for three consecutive days during the course of treatment for infection. 29 neonates without infection served as the control group. Septic patients, in particular, severe sepsis patients, had increased serum and urinary NGAL levels in the three subsequent days of observation. Five septic patients who developed AKI had elevated serum and urinary NGAL values to a similar extent as septic neonates without AKI. A strong correlation was found between the concentration of serum and urinary NGAL and inflammatory markers, such as CRP and procalcitonin. Serum and urinary NGAL levels were also significantly associated with NTISS (neonatal therapeutic intervention scoring system) values. We conclude that increased serum and urinary NGAL values are not solely a marker of AKI, and more accurately reflect the severity of inflammatory status.
authors.affiliation: Department of Neonatal Intensive Care, Upper Silesian Centre of Child's Health, Medical University of Silesia, Ul. Medykow 16, 40-752 Katowice, Poland.
authors.forename: Mike
authors.identifier: 0000-0002-9659-5322
authors.initials: M
authors.lastname: Smertka
authors.affiliation: Department of Neonatal Intensive Care, Upper Silesian Centre of Child's Health, Medical University of Silesia, Ul. Medykow 16, 40-752 Katowice, Poland.
authors.forename: Jolanta
authors.identifier: 0000-0002-2613-4264
authors.initials: J
authors.lastname: Wroblewska
authors.affiliation: Department of Neonatal Intensive Care, Upper Silesian Centre of Child's Health, Medical University of Silesia, Ul. Medykow 16, 40-752 Katowice, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Suchojad
authors.affiliation: Department of Neonatal Intensive Care, Upper Silesian Centre of Child's Health, Medical University of Silesia, Ul. Medykow 16, 40-752 Katowice, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Majcherczyk
authors.affiliation: Department of Neonatal Intensive Care, Upper Silesian Centre of Child's Health, Medical University of Silesia, Ul. Medykow 16, 40-752 Katowice, Poland.
authors.forename: Danuta
authors.initials: D
authors.lastname: Jadamus-Niebroj
authors.affiliation: Department of Neonatal Intensive Care, Upper Silesian Centre of Child's Health, Medical University of Silesia, Ul. Medykow 16, 40-752 Katowice, Poland.
authors.forename: Teresa
authors.initials: T
authors.lastname: Owsianka-Podlesny
authors.affiliation: Department of Pathophysiology, Medical University of Silesia, Ul. Medykow 18, 40-752 Katowice, Poland.
authors.forename: Aniceta
authors.initials: A
authors.lastname: Brzozowska
authors.affiliation: Department of Neonatal Intensive Care, Upper Silesian Centre of Child's Health, Medical University of Silesia, Ul. Medykow 16, 40-752 Katowice, Poland.
authors.forename: Iwona
authors.identifier: 0000-0002-1691-1541
authors.initials: I
authors.lastname: Maruniak-Chudek
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000473:pathology; D000209:Acute-Phase Proteins / Q000652:urine*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007249:Inflammation / Q000097:blood / Q000473:pathology / Q000652:urine; D000071068:Lipocalin-2; D054834:Lipocalins / Q000097:blood* / Q000652:urine*; D008297:Male; D011247:Pregnancy; D011518:Proto-Oncogene Proteins / Q000097:blood* / Q000652:urine*; D018805:Sepsis / Q000097:blood* / Q000473:pathology / Q000652:urine*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins