title: Comparison of ovulation induction and pregnacy outcomes in IVF patients with normal ovarian reserve who underwent long protocol with recombinant-FSH and highly purified-hMG.
abstract: OBJECTIVE
  Gonadotropins used in controlled ovarian stimulation have been increasing in number. Beside the recombinant preparations such as rec-FSH, rec-LH and h-hMG human-derived preparations have entered the market. We decided to compare the effects of rec-FSH and HP-hMG with GnRHa on embryo quality and pregnancy outcome in women undergoing an IVF cycle.
  
  
  METHODS
  In this study, data of 87 patients who had applied to our center from 2007 to 2008 and who had met all inclusion criteria, were analyzed. The patients underwent controlled ovarian hyperstimulation with HP-hMG, rec-FSH following down-regulation with a GnRHa in a long protocol, selected according to determined criteria and acquired embryo via IVF transfer.
  
  
  RESULTS
  Of the 87 patients, 44 were stimulated with rec-FSH and 43 with HP-hMG. Distribution of infertility causes was similar between the groups. Duration of gonadotropin administration (p=0.677, Student's t-test) and the total dose of gonadotropin received (p=0.392, Student's t-test) were similar between the two groups. The fertilization rate of the rec-FSH group was significantly higher than the HP-hMG group (p=0.001, Mann-Whitney U test). No significant differences were observed between the study groups in biochemical, clinical and ongoing pregnancy parameters.
  
  
  CONCLUSIONS
  The higher oocyte yield with rec-FSH does not result in higher quality embryos. LH activity in combination with FSH activity positively affected the oocyte and embryo maturation. Therefore, when we consider the clinical and ongoing pregnancy rates there is no inferiority of HP-hMG in controlled ovarian stimulation.
authors.affiliation: Department of Obstetrics and Gynecology, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Celik
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Education Hospital, Istanbul, Turkey.
authors.forename: Kenan
authors.initials: K
authors.lastname: Sofuoğlu
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Education Hospital, Istanbul, Turkey.
authors.forename: Selçuk
authors.initials: S
authors.lastname: Selçuk
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Education Hospital, Istanbul, Turkey.
authors.forename: Mehmet Reşit
authors.initials: MR
authors.lastname: Asoğlu
authors.affiliation: Department of Obstetrics and Gynecology, Namık Kemal University, Tekirdag, Turkey.
authors.forename: Remzi
authors.initials: R
authors.lastname: Abalı
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Education Hospital, Istanbul, Turkey.
authors.forename: Elçin
authors.initials: E
authors.lastname: Cetingöz
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Education Hospital, Istanbul, Turkey.
authors.forename: Bahar
authors.initials: B
authors.lastname: Baykal
authors.affiliation: Department of Obstetrics and Gynecology, Zeynep Kamil Training and Education Hospital, Istanbul, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Uludoğan
keywords: HP-hMG; Ovarian stimulation; rec-FSH