title: A Supramolecular Vesicle Based on the Complexation of p-Sulfonatocalixarene with Protamine and its Trypsin-Triggered Controllable-Release Properties.
abstract: Enzyme-responsive assembly represents one of the increasingly significant topics in biomaterials research and finds feasible applications to the controlled release of therapeutic agents at specific sites at which the target enzymes are located. In this work, based on the concept of host-guest chemistry, a trypsin-responsive supramolecular vesicle using p-sulfonatocalix[4]arene as the macrocyclic host and natural serine protease trypsin-cleavable cationic protein protamine as the guest molecule, is reported. The complexation of p-sulfonatocalix[4]arene with protamine directs the formation of a supramolecular binary vesicle, which is dissipated by trypsin with high selectivity. Therefore, the present system represents a principle-of-concept to build a controlled-release carrier at trypsin-overexpressed sites.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. China.|Tianjin Key Laboratory of Structure and Performance for Functional Molecules, Key Laboratory of Inorganic-Organic Hybrid, Functional Material Chemistry, Ministry of Education, College of Chemistry, Tianjin Normal University, Tianjin, 300387, P.R. China.
authors.forename: Kui
authors.initials: K
authors.lastname: Wang
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. China.
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Guo
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. China.
authors.forename: Meng-Yao
authors.initials: MY
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P.R. China. yuliu@nankai.edu.cn.
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D001557:Benzenesulfonates / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D047250:Calixarenes / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D011479:Protamines / Q000737:chemistry* / Q000378:metabolism; D013500:Surface Tension; D014357:Trypsin / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001557:Benzenesulfonates; D001672:Biocompatible Materials; D004337:Drug Carriers; D047028:Macrocyclic Compounds; D011479:Protamines; D047250:Calixarenes; D014357:Trypsin
keywords: aggregation; calixarenes; enzymes; host-guest systems; vesicles