title: Pulmonary metastasectomy and repeat metastasectomy for soft-tissue sarcoma.
abstract: BACKGROUND
  For patients with lung metastases from soft-tissue sarcoma, pulmonary metastasectomy is considered to be the only chance of possible cure. In this survey, we analyzed some potential prognostic factors affecting the outcome in these patients.
  
  
  METHODS
  34 patients who underwent pulmonary metastasectomy for soft-tissue sarcoma from April 1996 to April 2007, were enrolled in our study. The median follow-up period was 26 months. Survival curves, factors affecting the outcome, and treatment success rate were evaluated.
  
  
  RESULTS
  Complete resection was achieved in 88.2% of patients. There was no perioperative mortality. The median overall survival and median disease-free survival were 42 and 27 months, respectively. Incomplete resection and bilateral lung metastases had significant adverse effects on overall survival. Shorter disease-free interval (<18 months) was a significant predictor of survival on multivariate analysis. Metastasectomy was attempted in 12 cases of whom 50% remained disease-free to the end of follow-up.
  
  
  CONCLUSIONS
  Complete resection is the most important defining factor of success rate and survival. Patients with bilateral lung metastases or a shorter disease-free interval have significantly lower success rates. Repeat metastasectomy is curative in many patients.
authors.affiliation: Cancer Research Center, Omid Hospital, Mashhad, Iran.
authors.forename: Mehdi Seilanian
authors.initials: MS
authors.lastname: Toussi
authors.forename: Reza
authors.initials: R
authors.lastname: Bagheri
authors.forename: Mahdieh
authors.initials: M
authors.lastname: Dayani
authors.forename: Kazem
authors.initials: K
authors.lastname: Anvari
authors.forename: Shima
authors.initials: S
authors.lastname: Sheibani
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D018450:Disease Progression; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D059146:Metastasectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality; D015999:Multivariate Analysis; D018365:Neoplasm, Residual; D011013:Pneumonectomy / Q000009:adverse effects / Q000401:mortality; D016016:Proportional Hazards Models; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D012509:Sarcoma / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome
keywords: Lung neoplasms; reoperation; sarcoma; survival rate; treatment outcome