title: Oxidative status and acute phase reactants in patients with environmental asbestos exposure and mesothelioma.
abstract: OBJECTIVE
  The aim of this study was to investigate inflammatory indicators and oxidative status in patients with asbestos exposure with and without mesothelioma and to compare results with data from healthy subjects.
  
  
  METHODS
  Eighty people with exposure to environmental asbestos and without any disease, 46 mesothelioma patients, and a control group of 50 people without exposure to environmental asbestos were enrolled in this prospective study. Serum total oxidant level (TOL), total antioxidant capacity (TAC), and oxidative stress index (OSI), CRP, transferrin, ceruloplasmin, α-1 antitrypsin, ferritin, and copper levels were measured.
  
  
  RESULTS
  Mesothelioma group exhibited higher TOL, OSI, α1-antitrypsin, ferritin and copper levels as compared to the other groups (P < 0.001, P = 0.007, P < 0.0001, P < 0.001, and P < 0.001, resp.). Transferrin was lower in the mesothelioma group than in the other two groups (P < 0.001). The asbestos group had higher TOL, TAC, α1-antitrypsin, and transferrin levels (P < 0.001, P < 0.001, P < 0.001, and P < 0.001, resp.), as well as lower OSI and ferritin levels as compared to the control group (P < 0.001 and P < 0.001).
  
  
  CONCLUSIONS
  We believe that elevated acute phase reactants and oxidative stress markers (TOL and OSI) in the mesothelioma group can be used as predictive markers for the development of asbestos-related malignancy.
authors.affiliation: Department of Pulmonary Diseases, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Cengizhan
authors.initials: C
authors.lastname: Sezgi
authors.affiliation: Department of Pulmonary Diseases, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Mahsuk
authors.initials: M
authors.lastname: Taylan
authors.affiliation: Department of Pulmonary Diseases, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Hadice Selimoglu
authors.initials: HS
authors.lastname: Sen
authors.affiliation: Department of Biochemistry, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoğlu
authors.affiliation: Department of Pulmonary Diseases, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Halide
authors.initials: H
authors.lastname: Kaya
authors.affiliation: Department of Pulmonary Diseases, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Abakay
authors.affiliation: Department of Pulmonary Diseases, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Abakay
authors.affiliation: Department of Pulmonary Diseases, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Abdullah Cetin
authors.initials: AC
authors.lastname: Tanrıkulu
authors.affiliation: Department of Pulmonary Diseases, School of Medicine, Dicle University, 21280 Diyarbakir, Turkey.
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Senyiğit
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D000368:Aged; D001194:Asbestos / Q000633:toxicity*; D014408:Biomarkers, Tumor / Q000097:blood*; D016022:Case-Control Studies; D003300:Copper / Q000097:blood; D003430:Cross-Sectional Studies; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D008654:Mesothelioma / Q000097:blood* / Q000139:chemically induced / Q000175:diagnosis; D000086002:Mesothelioma, Malignant; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D018384:Oxidative Stress
chemical_list: D000209:Acute-Phase Proteins; D014408:Biomarkers, Tumor; D016877:Oxidants; D001194:Asbestos; D003300:Copper