title: Effect of uvulopalatopharyngoplasty on leptin and endothelial function in sleep apnea.
abstract: OBJECTIVE
  This study evaluated the effects of uvulopalatopharyngoplasty (UPPP) on serum leptin levels and endothelial function in patients with obstructive sleep apnea syndrome (OSAS).
  
  
  METHODS
  Fifteen healthy subjects and 35 patients with moderate to severe OSAS who desired UPPP were prospectively enrolled. The serum levels of leptin and nitric oxide derivative (NOx) from their peripheral blood samples were measured by enzyme-linked immunosorbent assay. All subjects participated in sleep studies, which were repeated 3 months after UPPP in the patients with OSAS.
  
  
  RESULTS
  Before UPPP, the patients with OSAS had a higher serum level of leptin and a lower NOx level than did the control subjects. The serum leptin levels in the 17 of the 35 patients with OSAS who were surgical responders decreased from 24.2 ± 6.1 ng/mL before operation to 15.9 ± 6.0 ng/mL after operation. The serum NOx levels in these 17 patients increased from 18.5 ± 7.5 µmol/L before operation to 27.3 ± 8.2 µmol/L after operation. In the 18 patients who were unresponsive to surgery, the serum leptin and NOx levels remained impaired after the UPPP.
  
  
  CONCLUSIONS
  Successful treatment of OSAS with UPPP leads to the normalization of serum leptin and NOx levels.
authors.affiliation: Chest Division, Department of Internal Medicine (Lin), Mackay Memorial Hospital, Taipei, Taiwan.
authors.forename: Ching-Chi
authors.initials: CC
authors.lastname: Lin
authors.forename: Ying-Piao
authors.initials: YP
authors.lastname: Wang
authors.forename: Kuo-Sheng
authors.initials: KS
authors.lastname: Lee
authors.forename: Shwu-Fang
authors.initials: SF
authors.lastname: Liaw
authors.forename: Chung-Hsin
authors.initials: CH
authors.lastname: Chiu
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D009765:Obesity / Q000150:complications; D013517:Otorhinolaryngologic Surgical Procedures / Q000379:methods; D010160:Palate, Soft / Q000601:surgery*; D010614:Pharynx / Q000601:surgery*; D017286:Polysomnography; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods; D012307:Risk Factors; D012720:Severity of Illness Index; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome; D014609:Uvula / Q000601:surgery*
chemical_list: D015415:Biomarkers; D016166:Free Radical Scavengers; D020738:Leptin; D009569:Nitric Oxide
keywords: endothelial function; leptin; nitric oxide derivative; obstructive sleep apnea syndrome; uvulopalatopharyngoplasty