title: Advances in multiple sclerosis and its variants: conventional and newer imaging techniques.
abstract: Multiple sclerosis (MS) and its variants are inflammatory as well as neurodegenerative diseases that diffusely affect the central nervous system (CNS). There is a poor correlation between traditional imaging findings and symptoms in patients with MS. Current research in conventional magnetic resonance (MR) imaging of MS and related diseases includes optimization of hardware and pulse sequences and the development of automated and semiautomated techniques to measure and quantify disease burden. Advanced nonconventional MR techniques such as diffusion tensor and functional MR imaging probe the changes found in the CNS, and correlate these findings with clinical measures of disease.
authors.affiliation: Neuroradiology Division, Department of Radiology, University of Maryland Medical Center, Baltimore, MD 21201, USA. Electronic address: tmiller5@umm.edu.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Miller
authors.affiliation: Neuroradiology Division, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Suyash
authors.initials: S
authors.lastname: Mohan
authors.affiliation: Neuroradiology Division, Department of Radiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
authors.forename: Asim F
authors.initials: AF
authors.lastname: Choudhri
authors.affiliation: Neuroradiology Division, Department of Radiology, University of Maryland Medical Center, Baltimore, MD 21201, USA.
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Gandhi
authors.affiliation: Neuroradiology Division, Department of Radiology, University of Maryland Medical Center, Baltimore, MD 21201, USA.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Jindal
mesh_terms: D003287:Contrast Media; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000473:pathology
chemical_list: D003287:Contrast Media
keywords: Conventional MR imaging; Diffusion tensor imaging; MR spectroscopy; Multiple sclerosis; Myelin free water component