title: Association between auditory P300, psychopathology, and memory function in drug-naïve schizophrenia.
abstract: The aim of this study was to explore memory deficits and psychopathology and their relationships with P300 in drug-naïve patients with schizophrenia. The Positive and Negative Syndrome Scale (PANSS) and the Wechsler Memory Scale-Revised were administered. Auditory event-related potentials elicited by an oddball paradigm were obtained. After controlling for age, sex, the results showed a statistically significant negative correlation between the total PANSS score and P300 amplitude at the parietal position (r = -0.66, p < 0.05). Moreover, visual memory was significantly positively correlated with P300 amplitude at the parietal position (r = 0.67, p < 0.05). After controlling for the duration of illness, the above correlations remained statistically significant. The correlation between P300 and the severity of psychopathology was reconfirmed in drug-naïve patients with schizophrenia. A possible contribution of memory decompensation in P300 among drug-naïve patients with schizophrenia may be considered, and the compensatory or Default Model Network might be a possible explanation of this association.
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, Douliou Branch, Yunlin, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Wei-Hung
authors.initials: WH
authors.lastname: Chang
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, Douliou Branch, Yunlin, Taiwan; Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Kao-Chin
authors.initials: KC
authors.lastname: Chen
authors.affiliation: Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Yen-Kuang
authors.initials: YK
authors.lastname: Yang
authors.affiliation: Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Po-See
authors.initials: PS
authors.lastname: Chen
authors.affiliation: Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Ru-Band
authors.initials: RB
authors.lastname: Lu
authors.affiliation: Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Tzung-Lieh
authors.initials: TL
authors.lastname: Yeh
authors.affiliation: Department of Psychiatry, Tainan Hospital, Department of Health, Executive Yuan, Tainan, Taiwan.
authors.forename: Carol Sheei-Meei
authors.initials: CS
authors.lastname: Wang
authors.affiliation: Addiction Research Center, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: ivylee@mail.ncku.edu.tw.
authors.forename: I-Hui
authors.initials: IH
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D011599:Psychopathology; D012559:Schizophrenia / Q000503:physiopathology*; D055815:Young Adult
keywords: Default model network; Drug-naïve schizophrenia; P300; Psychopathology; Visual memory