title: The neuroprotective role of acupuncture and activation of the BDNF signaling pathway.
abstract: Recent studies have been conducted to examine the neuroprotective effects of acupuncture in many neurological disorders. Although the neuroprotective effects of acupuncture has been linked to changes in signaling pathways, accumulating evidence suggest the participation of endogenous biological mediators, such as the neurotrophin (NT) family of proteins, specifically, the brain derived neurotrophic factor (BDNF). Accordingly, acupuncture can inhibit neurodegeneration via expression and activation of BDNF. Moreover, recent studies have reported that acupuncture can increase ATP levels at local stimulated points. We have also demonstrated that acupuncture could activate monocytes and increase the expression of BDNF via the stimulation of ATP. The purpose of this article is to review the recent findings and ongoing studies on the neuroprotective roles of acupuncture and therapeutic implications of acupuncture-induced activation of BDNF and its signaling pathway.
authors.affiliation: College of acupuncture, Fujian University of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou 350122, Fujian, China. bluelike1@sina.com.
authors.forename: Dong
authors.initials: D
authors.lastname: Lin
authors.affiliation: Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida, Tampa, FL 33612, USA. iked@health.usf.edu.
authors.forename: Ike
authors.initials: I
authors.lastname: De La Pena
authors.affiliation: College of acupuncture, Fujian University of Traditional Chinese Medicine, Minhou Shangjie, Fuzhou 350122, Fujian, China. linlili77fz@163.com.
authors.forename: Lili
authors.initials: L
authors.lastname: Lin
authors.affiliation: College of pharmacy, Department of pharmaceutical Sciences, University of South Florida, Tampa, FL 33612, USA. szhou@health.usf.edu.
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Zhou
authors.affiliation: Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida, Tampa, FL 33612, USA. cborlong@health.usf.edu.
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Borlongan
authors.affiliation: College of pharmacy, Department of pharmaceutical Sciences, University of South Florida, Tampa, FL 33612, USA. ccao@health.usf.edu.
authors.forename: Chuanhai
authors.initials: C
authors.lastname: Cao
mesh_terms: D015670:Acupuncture Therapy; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D000255:Adenosine Triphosphate; D011505:Protein-Tyrosine Kinases