title: Genome-wide probabilistic reconciliation analysis across vertebrates.
abstract: Gene duplication is considered to be a major driving force in evolution that enables the genome of a species to acquire new functions. A reconciliation--a mapping of gene tree vertices to the edges or vertices of a species tree--explains where gene duplications have occurred on the species tree. In this study, we sample reconciliations from a posterior over reconciliations, gene trees, edge lengths and other parameters, given a species tree and gene sequences. We employ a Bayesian analysis tool, based on the probabilistic model DLRS that integrates gene duplication, gene loss and sequence evolution under a relaxed molecular clock for substitution rates, to obtain this posterior.
authors.forename: Owais
authors.initials: O
authors.lastname: Mahmudi
authors.forename: Joel
authors.initials: J
authors.lastname: Sjöstrand
authors.forename: Bengt
authors.initials: B
authors.lastname: Sennblad
authors.forename: Jens
authors.initials: J
authors.lastname: Lagergren
mesh_terms: D000465:Algorithms; D000818:Animals; D001499:Bayes Theorem; D019143:Evolution, Molecular; D020440:Gene Duplication; D016678:Genome; D006801:Humans; D010802:Phylogeny; D014714:Vertebrates / Q000235:genetics*