title: Effects of andiroba (Carapa guianensis) oil on hepatic function of rats subjected to liver normothermic ischemia and reperfusion.
abstract: OBJECTIVE
  To evaluate the effects of the Andiroba (carapa guianensis) oil on liver function in rats subjected to normothermic ischemia / reperfusion injury.
  
  
  METHODS
  we divided 12 Wistar rats into two groups: saline (n = 6) and Andiroba (n = 6). The Andiroba group was treated with Andiroba oil (0.63 ml/kg orally) for seven days before surgery. Ischemia was induced by occlusion of the blood supply to the lateral and median lobes of the liver, using vascular clips, in both groups, for 45min, followed by reperfusion for 60 minutes later. We analyzed dosages of AST, ALT, Gamma-GT, and liver biodistribution of 99mTc phytate.
  
  
  RESULTS
  There was no significant difference in the percentage of radioactivity / gram of tissue (%ATI/g) in the right lobe of the saline group (17.53 ± 2.78) compared with the Andiroba group (18.04 ± 3.52) p = 0.461, the same occurring in the%ATI/g of the left lobe of the liver when the two groups were compared (p = 0.083). In the saline group, the%ATI/g was significantly higher in the non-ischemic right hepatic lobe (17.53 ± 2.78) when compared with the left lobe (5.04 ± 0.82) that suffered ischemia / reperfusion (p = 0.002). Significant differences also occurred when comparing the right (18.04 ± 3.52) and left (7.11 ± 1.86) lobes of the animals of the Andiroba group (p = 0.004). There was no significant difference in dosages of AST, ALT and Gamma- GT when comparing the two groups (p > 0.05).
  
  
  CONCLUSIONS
  Andiroba oil did not contribute to the protection of liver function in a rat model of liver injury induced by normothermic ischemia and reperfusion.
authors.forename: Nathalya Botelho
authors.initials: NB
authors.lastname: Brito
authors.forename: Jorge Mangabeira
authors.initials: JM
authors.lastname: de Souza Junior
authors.forename: Layra Ribeiro Sousa
authors.initials: LR
authors.lastname: Leão
authors.forename: Marcus Vinicius Henriques
authors.initials: MV
authors.lastname: Brito
authors.forename: Amália Cínthia Meneses
authors.initials: AC
authors.lastname: Rêgo
authors.forename: Aldo Cunha
authors.initials: AC
authors.lastname: Medeiros
mesh_terms: D000818:Animals; D008099:Liver / Q000098:blood supply* / Q000187:drug effects* / Q000502:physiology; D008297:Male; D029582:Meliaceae; D008517:Phytotherapy; D010938:Plant Oils / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy*
chemical_list: D010938:Plant Oils