title: Molecular recognition of nucleotides in water by scorpiand-type receptors based on nucleobase discrimination.
abstract: The detection of nucleotides is of crucial importance because they are the basic building blocks of nucleic acids. Scorpiand-based polyamine receptors functionalized with pyridine or anthracene units are able to form stable complexes with nucleotides in water, based on coulombic, π-π stacking, and hydrogen-bonding interactions. This behavior has been rationalized by means of an exploration with NMR spectroscopy and DFT calculations. Binding constants were determined by potentiometry. Fluorescence spectroscopy studies have revealed the potential of these receptors as sensors to effectively and selectively distinguish guanosine-5'-triphosphate (GTP) from adenosine-5'-triphosphate (ATP).
authors.affiliation: Molecular Science Institute (ICMol), Universitat de València, C/Catedrático José Beltrán 2, 46980 Paterna (Spain).
authors.forename: Mario
authors.initials: M
authors.lastname: Inclán
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Albelda
authors.forename: Esther
authors.initials: E
authors.lastname: Carbonell
authors.forename: Salvador
authors.initials: S
authors.lastname: Blasco
authors.forename: Antonio
authors.initials: A
authors.lastname: Bauzá
authors.forename: Antonio
authors.initials: A
authors.lastname: Frontera
authors.forename: Enrique
authors.initials: E
authors.lastname: García-España
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry*; D006160:Guanosine Triphosphate / Q000737:chemistry*; D006860:Hydrogen Bonding; D008962:Models, Theoretical; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009711:Nucleotides / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods; D014867:Water / Q000737:chemistry*
chemical_list: D009711:Nucleotides; D014867:Water; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate
keywords: molecular recognition; nucleotides; scorpiands; sensors; supramolecular chemistry