title: Demonstration of plasmid-mediated drug resistance in Mycobacterium abscessus.
abstract: Plasmid-mediated kanamycin resistance was detected in a strain of Mycobacterium abscessus subsp. bolletii responsible for a nationwide epidemic of surgical infections in Brazil. The plasmid did not influence susceptibility to tobramycin, streptomycin, trimethoprim-sulfamethoxazole, clarithromycin, or ciprofloxacin. Plasmid-mediated drug resistance has not been described so far in mycobacteria.
authors.affiliation: Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, São Paulo, Brazil.
authors.forename: Cristianne Kayoko
authors.initials: CK
authors.lastname: Matsumoto
authors.forename: Paulo José Martins
authors.initials: PJ
authors.lastname: Bispo
authors.forename: Katiane
authors.initials: K
authors.lastname: Santin
authors.forename: Christiane Lourenço
authors.initials: CL
authors.lastname: Nogueira
authors.forename: Sylvia Cardoso
authors.initials: SC
authors.lastname: Leão
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015373:Bacterial Typing Techniques / Q000379:methods; D001938:Brazil; D004269:DNA, Bacterial / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D009161:Mycobacterium / Q000187:drug effects / Q000235:genetics*; D009164:Mycobacterium Infections / Q000188:drug therapy / Q000382:microbiology*; D010957:Plasmids / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial