title: Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair.
abstract: The cellular response to DNA double-stranded breaks (DSBs) involves a conserved mechanism of recruitment and activation of numerous proteins involved in this pathway. The events that trigger this response in mammalian cells involve several post-translational modifications, but the role of non-proteasomal ubiquitin signaling is particularly central to this pathway. Recent work has demonstrated that ubiquitination does not act alone, but in concert with other post-translational modifications, including phosphorylation, methylation, acetylation, ADP-ribosylation, and other ubiquitin-like modifiers, particularly SUMOylation. We review novel and exciting crosstalk mechanisms between ubiquitination and other post-translational modifications, many of which work synergistically with each other to activate signaling events and help recruit important DNA damage effector proteins, particularly BRCA1 (breast cancer 1, early onset) and 53BP1 (tumor protein p53 binding protein 1), to sites of DNA damage.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Brickner
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
authors.forename: Mona C
authors.initials: MC
authors.lastname: Majid
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: Mosammaparast@wustl.edu.
authors.forename: Nima
authors.initials: N
authors.lastname: Mosammaparast
mesh_terms: D000818:Animals; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair / Q000235:genetics*; D006801:Humans; D011499:Protein Processing, Post-Translational / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D025801:Ubiquitin / Q000235:genetics* / Q000378:metabolism*
chemical_list: D002843:Chromatin; D025801:Ubiquitin
keywords: DNA damage; chromatin; signaling; ubiquitin