title: Comorbid case of IgG4-related disease and primary Sjögren's syndrome.
abstract: A 63-year-old man with enlargement of the bilateral submandibular glands visited with elevated serum IgG4. A biopsy specimen showed plasma cell infiltration with more than 50% IgG4/IgG staining, suggesting the existence of IgG4-related disease (IgG4-RD). Positive anti-SS-A/Ro antibody and the labial salivary gland's biopsy suggested existence of primary Sjögren's syndrome (pSS). Administration of glucocorticoid improved the serum IgG4 level while reducing the submandibular gland lesions. Positive TUNEL staining suggested the coexistence of IgG4-RD and pSS.
authors.affiliation: Department of Immunology and Rheumatology, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki , Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Nakashima
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Horai
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Takagi
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology; D013363:Submandibular Gland / Q000473:pathology
chemical_list: D007074:Immunoglobulin G
keywords: Apoptosis; IgG4-related disease; Sjögren's syndrome; TUNEL