title: Assessment of Interleukins IL-4, IL-6, IL-8, IL-10 in Acute Urticaria.
abstract: BACKGROUND
  Urticaria is a skin disease that affects approximately 5% of the general population and manifests itself, not only as an acute but also as a chronic disease. The etiology of the disease varies as well as its clinical manifestations which extend from the presence of urticarial hives to the potentially mortal angioedema. There is a great interest to the disease not only due to its special clinical manifestation but also due to its pathogenetic mechanism. New data in the medical bibliography support the participation of interleukins (ILs) in the pathophysiology of urticaria. The aim of the study is to contribute in the comprehension of possible participation of certain ILs in the pathogenesis of acute urticaria.
  
  
  METHODS
  Our study concerns four ILs, IL-4, IL-6, IL-8 and IL-10, simultaneously and their quantitative changes during the acute phase of urticaria as well as 2 weeks after drug administration. Moreover, ILs levels of patients were compared with those of matched healthy controls. All measurements have been done by the ELISA method. The statistical analysis was done by SPSS.
  
  
  RESULTS
  The results present increased levels (in 51 patients vs. 22 matched healthy controls) of all four ILs during the acute phase. Especially for IL-4 this increase was statistically very significant (P < 0.001). Statistically marginally significant decrease was also observed for IL-10 concentrations (P < 0.059), for the two blood samples (acute phase and 2 weeks later).
  
  
  CONCLUSIONS
  It is suggested by the present study that certain ILs might play an important role in the pathogenetic mechanism of urticaria. IL-4 and IL-10 participation seems to be relatively more significant. Possibly, ILs, liberated by mast cells, induce an influx of leukocytes in the dermis, therefore participating in the development of acute urticaria inflammation.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Democritus University of Thrace, Greece.
authors.forename: Jordan
authors.initials: J
authors.lastname: Papadopoulos
authors.affiliation: Department of Dermatology, Faculty of Medicine, Democritus University of Thrace, Greece.
authors.forename: Anthony
authors.initials: A
authors.lastname: Karpouzis
authors.affiliation: Laboratory of Biochemistry, Faculty of Medicine, Democritus University of Thrace, Greece.
authors.forename: John
authors.initials: J
authors.lastname: Tentes
authors.affiliation: Department of Dermatology, Faculty of Medicine, Democritus University of Thrace, Greece.
authors.forename: Constantin
authors.initials: C
authors.lastname: Kouskoukis
keywords: Acute urticaria pathogenesis; IL-10; IL-4; IL-6; IL-8; Interleukins