title: Chitotriosidase as a possible marker of clinically evidenced atherosclerosis in dyslipidemic children.
abstract: A correlation has been clearly shown between inflammation markers and subclinical atherosclerosis markers in the early stages of atherogenesis in subjects with familial hypercholesterolemia (FH). The aim of this study was to investigate potential inflammation markers in the diagnosis of atherosclerosis in children with FH. A total of 48 dyslipidemic children and 24 healthy age-matched control subjects were taken into study. Inflammation and macrophage activation markers (hsCRP, myeloperoxidase, chitotriosidase, YKL-40, TNF-α, IL-6, IL-18, MMP-1 and MMP-9) and lipid parameters of all patients were measured. Carotid intima-media thickness (cIMT) and flow-mediated dilation (FMD) levels were determined. Our data suggested that clinically evidenced (by cIMT and FMD levels) atherosclerosis starts in the early ages in hypercholesterolemic children. Higher cholesterol levels strongly correlated with macrophage activation markers (ChT, YKL-40 and myeloperoxidase). ChT and YKL-40 seem to be the more predictable markers of atherosclerosis even in early ages (<6 years old) than other classical inflammation markers such as hs-CRP, IL-6 and TNF-α.
authors.forename: Turan
authors.initials: T
authors.lastname: Kologlu
authors.forename: Sema Kalkan
authors.initials: SK
authors.lastname: Ucar
authors.forename: Erturk
authors.initials: E
authors.lastname: Levent
authors.forename: Yasemin Delen
authors.initials: YD
authors.lastname: Akcay
authors.forename: Mahmut
authors.initials: M
authors.lastname: Coker
authors.forename: Eser Yıldırım
authors.initials: EY
authors.lastname: Sozmen
mesh_terms: D054392:Adipokines / Q000097:blood*; D000293:Adolescent; D050197:Atherosclerosis / Q000175:diagnosis*; D015415:Biomarkers; D001783:Blood Flow Velocity; D002097:C-Reactive Protein; D059168:Carotid Intima-Media Thickness; D054405:Chemokine CCL3 / Q000097:blood; D054407:Chemokine CCL4 / Q000097:blood; D002648:Child; D002675:Child, Preschool; D000071451:Chitinase-3-Like Protein 1; D004730:Endothelium, Vascular; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000175:diagnosis*; D007249:Inflammation; D037102:Lectins / Q000097:blood*; D008262:Macrophage Activation / Q000502:physiology*; D014664:Vasodilation
chemical_list: D054392:Adipokines; D015415:Biomarkers; C084533:CHI3L1 protein, human; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D000071451:Chitinase-3-Like Protein 1; D037102:Lectins; D002097:C-Reactive Protein; D006596:Hexosaminidases; C086400:chitotriosidase