title: Self-assembling peptide-based delivery of therapeutics for myocardial infarction.
abstract: Drug and cell delivery systems could be modulated to serve as instructive microenvironments in regenerative medicine. Towards this end, several synthetic biomaterials have been developed to mimic the natural extracellular matrix (ECM) for therapeutic use. These include synthetic polymers, decellularized ECM, self-assembling polymers, and cell-responsive hydrogels with varied applications. Here, we describe the development of a self-assembling peptide hydrogel and its potential use as a cell and growth factor delivery vehicle to the infarcted heart in a rodent model of myocardial infarction.
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.
authors.forename: Archana V
authors.initials: AV
authors.lastname: Boopathy
authors.forename: Michael E
authors.initials: ME
authors.lastname: Davis
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry; D002460:Cell Line; D064987:Cell- and Tissue-Based Therapy / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D005109:Extracellular Matrix / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism / Q000494:pharmacology; D008969:Molecular Sequence Data; D009203:Myocardial Infarction / Q000473:pathology / Q000628:therapy*; D010455:Peptides / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D020100:Hydrogels; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides