title: Exocyst proteins in cytokinesis: Regulation by Rab11.
abstract: The Exocyst is an octameric protein complex comprised of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84 subunits.(1, 2) This complex was first identified in budding yeast where it acts to target vesicles to the bud tip and the cleavage furrow.(3) Here, we show that all Exocyst subunits are required for cytokinesis in mammalian cells. We further show that a subset of Exocyst proteins are differentially regulated by Rab11, consistent with recent studies implicating Rab11 vesicles in Exocyst protein trafficking.
authors.affiliation: Henry Wellcome Laboratory of Cell Biology; Institute of Molecular, Cell, and Systems Biology; College of Medical, Veterinary, and Life Sciences; University of Glasgow; Glasgow UK.
authors.forename: Hélia
authors.initials: H
authors.lastname: Neto
authors.affiliation: Henry Wellcome Laboratory of Cell Biology; Institute of Molecular, Cell, and Systems Biology; College of Medical, Veterinary, and Life Sciences; University of Glasgow; Glasgow UK.
authors.forename: Gemma
authors.initials: G
authors.lastname: Balmer
authors.affiliation: Henry Wellcome Laboratory of Cell Biology; Institute of Molecular, Cell, and Systems Biology; College of Medical, Veterinary, and Life Sciences; University of Glasgow; Glasgow UK.
authors.forename: Gwyn
authors.initials: G
authors.lastname: Gould
keywords: Rab11; abscission; endosome; exocyst; mitosis