title: Modeling of progesterone-induced intracellular calcium signaling in human spermatozoa.
abstract: Calcium ion is a secondary messenger of mammalian spermatozoa. The dynamic change of its concentration plays a vital role in the process of sperm motility, capacitation, acrosome and fertilization. Progesterone released by the cumulus cells, as a potent stimulator of fertilization, can activate the calcium channels on the plasma membrane, which in turn triggers the dynamic change of intracellular calcium concentration. In this paper, a mathematical model of calcium dynamic response in mammalian spermatozoa induced by progesterone is proposed and numerical simulation of the dynamic model is conducted. The results show that the dynamic response of calcium concentration predicted by the model is in accordance with experimental evidence. The proposed dynamic model can be used to explain the phenomena observed in the experiments and predict new phenomena to be revealed by experimental investigations, which will provide the basis to quantitatively investigate the fluid mechanics and biochemistry for the sperm motility induced by progesterone.
authors.affiliation: Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, No. 2, Linggong Rd., Dalian 116023, China.
authors.forename: Long-Fei
authors.initials: LF
authors.lastname: Li
authors.affiliation: Department of Electrical and Computer Engineering, National University of Singapore, Singapore 117576, Singapore.
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiang
authors.affiliation: Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, No. 2, Linggong Rd., Dalian 116023, China.
authors.forename: Ya-Bing
authors.initials: YB
authors.lastname: Zhu
authors.affiliation: Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, No. 2, Linggong Rd., Dalian 116023, China. Electronic address: krqin@dlut.edu.cn.
authors.forename: Kai-Rong
authors.initials: KR
authors.lastname: Qin
mesh_terms: D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008954:Models, Biological; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D013081:Sperm Motility / Q000187:drug effects / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism
chemical_list: D011374:Progesterone; D002118:Calcium
keywords: Calcium signaling; Human spermatozoa; Mathematical modeling; Progesterone