title: Does the haplotype Met408-Del420, which was apparently predictive for imatinib efficacy, really exist and how strongly may it affect OCT1 activity?
authors.affiliation: Institute of Clinical Pharmacology, University Medical Center, Georg-August-Universität Göttingen, Göttingen, Germany.
authors.forename: Mladen V
authors.initials: MV
authors.lastname: Tzvetkov
authors.forename: Tina
authors.initials: T
authors.lastname: Seitz
authors.forename: Kristin
authors.initials: K
authors.lastname: Bokelmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Mueller
authors.forename: Jürgen
authors.initials: J
authors.lastname: Brockmöller
authors.forename: Hermann
authors.initials: H
authors.lastname: Koepsell
mesh_terms: D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001549:Benzamides / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018389:Codon, Nonsense; D004252:DNA Mutational Analysis; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D017353:Gene Deletion; D006580:Genetic Carrier Screening; D057809:HEK293 Cells; D006239:Haplotypes; D006801:Humans; D000068877:Imatinib Mesylate; D008715:Methionine / Q000235:genetics; D027702:Organic Cation Transporter 1 / Q000235:genetics*; D010879:Piperazines / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011379:Prognosis; D011743:Pyrimidines / Q000493:pharmacokinetics / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D018389:Codon, Nonsense; D027702:Organic Cation Transporter 1; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D008715:Methionine