title: Application of routine electronic health record databases for pharmacogenetic research.
abstract: Inter-individual variability in drug responses is a common problem in pharmacotherapy. Several factors (non-genetic and genetic) influence drug responses in patients. When aiming to obtain an optimal benefit-risk ratio of medicines and with the emergence of genotyping technology, pharmacogenetic studies are important for providing recommendations on drug treatments. Advances in electronic healthcare information systems can contribute to increasing the quality and efficiency of such studies. This review describes the definition of pharmacogenetics, gene selection and study design for pharmacogenetic research. It also summarizes the potential of linking pharmacoepidemiology and pharmacogenetics (along with its strengths and limitations) and provides examples of pharmacogenetic studies utilizing electronic health record databases.
authors.affiliation: Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands; Department of Pharmacology and Therapeutics, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin, Indonesia.
authors.forename: A
authors.initials: A
authors.lastname: Yasmina
authors.forename: V H M
authors.initials: VH
authors.lastname: Deneer
authors.forename: A H
authors.initials: AH
authors.lastname: Maitland-van der Zee
authors.forename: T P
authors.initials: TP
authors.lastname: van Staa
authors.forename: A
authors.initials: A
authors.lastname: de Boer
authors.forename: O H
authors.initials: OH
authors.lastname: Klungel
mesh_terms: D057286:Electronic Health Records / Q000706:statistics & numerical data*; D056726:Genetic Association Studies / Q000379:methods*; D036281:Genetic Research; D006801:Humans; D017891:Pharmacoepidemiology / Q000379:methods; D010597:Pharmacogenetics / Q000379:methods*; D012107:Research Design
keywords: electronic health records; pharmacogenetics