title: Imaging manifestations of the leukodystrophies, inherited disorders of white matter.
abstract: The leukodystrophies are a diverse set of inherited white matter disorders and are uncommonly encountered by radiologists in everyday practice. As a result, it is challenging to recognize these disorders and to provide a useful differential for the referring physician. In this article, leukodystrophies are reviewed from the perspective of 4 imaging patterns: global myelination delay, periventricular/deep white matter predominant, subcortical white matter predominant, and mixed white/gray matter involvement patterns. Special emphasis is placed on pattern recognition and unusual combinations of findings that may suggest a specific diagnosis.
authors.affiliation: Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address: edward.yang@childrens.harvard.edu.
authors.forename: Edward
authors.initials: E
authors.lastname: Yang
authors.affiliation: Department of Radiology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Sanjay P
authors.initials: SP
authors.lastname: Prabhu
mesh_terms: D003937:Diagnosis, Differential; D020279:Hereditary Central Nervous System Demyelinating Diseases / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*
keywords: Demyelination; Dysmyelination; Inborn error of metabolism; Leukodystrophy; Spectroscopy; White matter