title: Autologous stem cell transplantation in mantle cell lymphoma: a report from the SFGM-TC.
abstract: Autologous stem cell transplantation (ASCT) is considered as an attractive treatment option for young mantle cell lymphoma (MCL) patients. This retrospective SFGM-TC study analyzed the outcome of 500 MCL patients treated with ASCT and investigated parameters that may modify the outcome of patients who proceeded to ASCT upfront (n=396). For all patients, median age at ASCT was 56 years (range, 26-71). Median follow-up was 34 months. Three-year progression free survival (PFS) and overall survival (OS)were 63.5% [95 % CI, 58.7–68.6 %] and 79.5 % [95 % CI, 75.3–83.4 %], respectively. Median time from ASCT to relapse was 22 months (range, 0–136 m). For patients transplanted upfront and in multivariate analysis, age (HR=2 [1.2–3.4], p=.01, and HR=2.3 [1.2–4.5], p=.01), disease status at time of ASCT (HR=1.7 [1.1–2.6], p=.01 and HR=1.8 [1.1–3.1], p=.03), and use of rituximab (HR=0.5 [0.3–0.8], p=.002 and HR=0.5 [0.3–0.9], p=.01) were statistically predictive for both PFS and OS. Also, first line treatment including anthracycline and high-dose cytarabine followed by ASCT conditioned with TAM improved PFS. To conclude, this study suggests that ASCT in MCL can provide a high response rate but may not be sufficient to cure MCL even when ASCT is performed upfront, highlighting the need for innovative approaches before ASCT, aiming to increase complete response rate, and after ASCT, to maintain response.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Touzeau
authors.forename: Christophe
authors.initials: C
authors.lastname: Leux
authors.forename: Reda
authors.initials: R
authors.lastname: Bouabdallah
authors.forename: Murielle
authors.initials: M
authors.lastname: Roussel
authors.forename: Richard
authors.initials: R
authors.lastname: Delarue
authors.forename: Krimo
authors.initials: K
authors.lastname: Bouabdallah
authors.forename: Catherine
authors.initials: C
authors.lastname: Thieblemont
authors.forename: Victoria
authors.initials: V
authors.lastname: Cacheux
authors.forename: Guillaume
authors.initials: G
authors.lastname: Cartron
authors.forename: Laetitia
authors.initials: L
authors.lastname: Compain
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Gyan
authors.forename: Franck
authors.initials: F
authors.lastname: Morschhauser
authors.forename: Olivier
authors.initials: O
authors.lastname: Casasnovas
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Moles
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Michallet
authors.forename: Remy
authors.initials: R
authors.lastname: Gressin
authors.forename: Gandhi
authors.initials: G
authors.lastname: Damaj
authors.forename: Christian
authors.initials: C
authors.lastname: Rose
authors.forename: Anne
authors.initials: A
authors.lastname: Sirvent
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.forename: Noel
authors.initials: N
authors.lastname: Milpied
authors.forename: Steven
authors.initials: S
authors.lastname: Le Gouill
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D018943:Anthracyclines / Q000008:administration & dosage; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D064592:Autografts; D003561:Cytarabine / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D033581:Stem Cell Transplantation; D015996:Survival Rate; D019172:Transplantation Conditioning
chemical_list: D018943:Anthracyclines; D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine