title: The vinylogous Mukaiyama aldol reaction (VMAR) in natural product synthesis.
abstract: The vinylogous Mukaiyama aldol reaction (VMAR) allows efficient access to larger segments for complex natural product synthesis, primarily polyketides, through the construction of vicinal hydroxyl and methyl groups as well as di and tri-substituted double bonds in one single operation. In this review, we will highlight stereoselective protocols that have been used in natural product synthesis and cluster them into the four groups that can be obtained from different silyl ketene acetals or enol ethers. At the beginning, an overview on different stereoselective VMARs is presented; disregarding their applications in total syntheses.
authors.affiliation: Institute for Organic Chemistry and Centre of Biomolecular Drug Research (BMWZ), Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany. Markus.Kalesse@oci.uni-hannover.de.
authors.forename: Markus
authors.initials: M
authors.lastname: Kalesse
authors.forename: Martin
authors.initials: M
authors.lastname: Cordes
authors.forename: Gerrit
authors.initials: G
authors.lastname: Symkenberg
authors.forename: Hai-Hua
authors.initials: HH
authors.lastname: Lu
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D001688:Biological Products; C116609:3-hydroxybutanal