title: Characteristic systemic cytokine responses in children with human bocavirus-positive lower respiratory tract infection.
abstract: To investigate systemic cytokine responses in human bocavirus (HBoV)-associated lower respiratory tract infection, serum cytokine profiles were analyzed in HBoV positive-children (n=14) using multiplex immunoassay. Concentrations of TNF-a, IL-2, IL-5 and IL-8 on admission were significantly different from those of respiratory syncytial virus-positive children (n=28). This unique cytokine response might partly explain some characteristic clinical features of HBoV-associated respiratory infection.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Hirose
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Hamada
authors.forename: Taku
authors.initials: T
authors.lastname: Wakui
authors.forename: Tomoko
authors.initials: T
authors.lastname: Ogawa
authors.forename: Masaru
authors.initials: M
authors.lastname: Terai
mesh_terms: D002675:Child, Preschool; D016207:Cytokines / Q000097:blood* / Q000276:immunology; D005260:Female; D056661:Human bocavirus / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008297:Male; D010322:Parvoviridae Infections / Q000097:blood* / Q000276:immunology / Q000821:virology; D012141:Respiratory Tract Infections / Q000097:blood* / Q000276:immunology / Q000821:virology
chemical_list: D016207:Cytokines