title: Role of elevated cancer antigen 19-9 in women with mature cystic teratoma.
abstract: The objective of this study was to determine how often an elevated cancer antigen (CA) 19-9 (≥ 37 U/mL) was present during the preoperative evaluation of women with a mature cystic teratoma (MCT). This was a retrospective, consecutive case series (N = 139) of histologically proven MCT treated at Montefiore Medical Center from 1997 to 2008. Data were analyzed for patient and tumor characteristics, tumor markers (CA 19-9, CA 125, and carcinoembryonic antigen [CEA]), preoperative imaging, and procedure. CA 19-9 was elevated in 37.4% of patients. Elevated CA 19-9 was not significantly associated with age, race, CA 125 (≥35 U/mL), CEA (≥5 ng/mL), MCT size, or the presence of bilateral MCTs. Of the patients, 59% were ≥40 years old. Age <40 years was associated with cystectomy rather than oophorectomy (P < .001), regardless of CA 19-9 (P = .09). Elevated preoperative CA 19-9 in patients with MCT was associated with increased preoperative computed tomography (P = .04).
authors.affiliation: Department of Obstetrics & Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine, and Montefiore Medical Center, Bronx, NY, USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Frimer
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Western Connecticut Health Network, Danbury, CT, USA.
authors.forename: Brandon-Luke L
authors.initials: BL
authors.lastname: Seagle
authors.affiliation: Department of Obstetrics & Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine, and Montefiore Medical Center, Bronx, NY, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Chudnoff
authors.affiliation: Department of Obstetrics & Gynecology and Women's Health, Division of Gynecologic Oncology, Albert Einstein College of Medicine, and Montefiore Medical Center, Bronx, NY, USA Division of Gynecologic Oncology, Albert Einstein Cancer Center, Bronx, NY, USA.
authors.forename: Gary L
authors.initials: GL
authors.lastname: Goldberg
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Western Connecticut Health Network, Danbury, CT, USA shohreh.shahabi@wchn.org.
authors.forename: Shohreh
authors.initials: S
authors.lastname: Shahabi
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010052:Ovariectomy / Q000639:trends; D012189:Retrospective Studies; D013724:Teratoma / Q000097:blood* / Q000175:diagnosis* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen
keywords: CA 19-9; adnexal mass; ovarian tumor; teratoma; tumor marker