title: [Interleukin-7, a new immunoadjuvant for the treatment of septic shock].
abstract: Sepsis-induced immunosuppression is a new paradigm in sepsis pathophysiology. This up-to-date review integrates recent facts in the field. It focuses on immune dysfunctions described so far in septic patients (especially regarding T lymphocytes), on the mechanisms sustaining this immune failure, on the monitoring of the pro-/anti-inflammatory balance rapidly changing over time and on new promising therapeutic avenues emerging from those recent findings. Of them, the case of interleukin-7 is more specifically envisaged.
authors.affiliation: Hospices civils de Lyon, hôpital Edouard Herriot, laboratoire d'immunologie cellulaire, 5, place d'Arsonval, 69437 Lyon Cedex 03, France - EAM 4174 Hémostase, sepsis, inflammation, Hospices civils de Lyon, université Lyon I, Lyon, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Monneret
authors.affiliation: Hospices civils de Lyon, hôpital Edouard Herriot, laboratoire d'immunologie cellulaire, 5, place d'Arsonval, 69437 Lyon Cedex 03, France.
authors.forename: Astrid
authors.initials: A
authors.lastname: Villars-Méchin
authors.affiliation: Hospices civils de Lyon, hôpital Edouard Herriot, laboratoire d'immunologie cellulaire, 5, place d'Arsonval, 69437 Lyon Cedex 03, France - EAM 4174 Hémostase, sepsis, inflammation, Hospices civils de Lyon, université Lyon I, Lyon, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Demaret
authors.affiliation: Hospices civils de Lyon, hôpital Edouard Herriot, laboratoire d'immunologie cellulaire, 5, place d'Arsonval, 69437 Lyon Cedex 03, France.
authors.forename: Anne-Perrine
authors.initials: AP
authors.lastname: Foray
authors.affiliation: Hospices civils de Lyon, hôpital Edouard Herriot, laboratoire d'immunologie cellulaire, 5, place d'Arsonval, 69437 Lyon Cedex 03, France - EAM 4174 Hémostase, sepsis, inflammation, Hospices civils de Lyon, université Lyon I, Lyon, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Venet
mesh_terms: D000276:Adjuvants, Immunologic; D017209:Apoptosis; D018791:CD4 Lymphocyte Count; D006801:Humans; D007165:Immunosuppression Therapy; D015851:Interleukin-7 / Q000502:physiology / Q000627:therapeutic use*; D008231:Lymphopenia; D020395:Receptors, Interleukin-7; D011994:Recombinant Proteins; D012772:Shock, Septic / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D015851:Interleukin-7; D020395:Receptors, Interleukin-7; D011994:Recombinant Proteins