title: First clinical uterus transplantation trial: a six-month report.
abstract: OBJECTIVE
  To report the 6-month results of the first clinical uterus transplantation (UTx) trial. This type of transplantation may become a treatment of absolute uterine-factor infertility (AUFI).
  
  
  METHODS
  Prospective observational study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Nine AUFI women and their live uterine donors, the majority being mothers.
  
  
  METHODS
  Live-donor UTx and low-dose induction immunosuppression.
  
  
  METHODS
  Data from preoperative investigations, surgery and follow-up for 6 months.
  
  
  RESULTS
  Durations of donor and recipient surgery ranged from 10 to 13 hours and from 4 to 6 hours, respectively. No immediate perioperative complications occurred in any of the recipients. After 6 months, seven uteri remained viable with regular menses. Mild rejection episodes occurred in four of these patients. These rejection episodes were effectively reversed by corticosteroid boluses. The two graft losses were because of acute bilateral thrombotic uterine artery occlusions and persistent intrauterine infection.
  
  
  CONCLUSIONS
  The results demonstrate the feasibility of live-donor UTx with a low-dose immunosuppressive protocol.
  
  
  BACKGROUND
  NCT01844362.
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden. Electronic address: mats.brannstrom@obgyn.gu.se.
authors.forename: Mats
authors.initials: M
authors.lastname: Brännström
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Liza
authors.initials: L
authors.lastname: Johannesson
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Pernilla
authors.initials: P
authors.lastname: Dahm-Kähler
authors.affiliation: Department of Anesthesiology and Intensive Care, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Enskog
authors.affiliation: Department of Clinical Pathology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Mölne
authors.affiliation: Department of Transplantation, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Niclas
authors.initials: N
authors.lastname: Kvarnström
authors.affiliation: Department of Gynecology and Obstetrics, La Fe University Hospital, University of Valencia, Valencia, Spain.
authors.forename: Cesar
authors.initials: C
authors.lastname: Diaz-Garcia
authors.affiliation: Department of Obstetrics and Gynecology, Griffith University, Gold Coast, Southport, Queensland, Australia.
authors.forename: Ash
authors.initials: A
authors.lastname: Hanafy
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Lundmark
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Janusz
authors.initials: J
authors.lastname: Marcickiewicz
authors.affiliation: Department of Transplantation, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Markus
authors.initials: M
authors.lastname: Gäbel
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Klaus
authors.initials: K
authors.lastname: Groth
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Randa
authors.initials: R
authors.lastname: Akouri
authors.affiliation: Department of Obstetrics and Gynecology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Saskia
authors.initials: S
authors.lastname: Eklind
authors.affiliation: Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Holgersson
authors.affiliation: Department of Surgery, Cleveland Clinic, Weston, Florida.
authors.forename: Andreas
authors.initials: A
authors.lastname: Tzakis
authors.affiliation: Department of Transplantation, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Olausson
mesh_terms: D000017:ABO Blood-Group System / Q000097:blood / Q000276:immunology; D000328:Adult; D001787:Blood Group Incompatibility / Q000097:blood / Q000276:immunology / Q000517:prevention & control; D015331:Cohort Studies; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007247:Infertility, Female / Q000188:drug therapy / Q000453:epidemiology / Q000601:surgery*; D008875:Middle Aged; D011446:Prospective Studies; D016378:Tissue Transplantation / Q000379:methods*; D014599:Uterus / Q000276:immunology / Q000637:transplantation*
chemical_list: D000017:ABO Blood-Group System; D007166:Immunosuppressive Agents
keywords: Infertility; human; transplantation; uterus