title: Distinguishing patients with stage I lung cancer versus control individuals using serum mass profiling.
abstract: Serum mass profiling can discern physiological changes associated with specific disease states and their progression. Sera (86 total) from control individuals and patients with stage I nonsmall cell lung cancer or benign small pulmonary nodules were discriminated retrospectively by serum changes discerned by mass profiling. Control individuals were distinguished from patients with Stage I lung cancer or benign nodules with test sensitivities of 89% and 83%. Lung cancer patients versus those with benign nodules were distinguished with 80% sensitivity. This study exhibits progress toward a minimally-invasive aid in early detection of lung cancer and monitoring small pulmonary nodules for malignancy.
authors.affiliation: 1Departments of 1Biochemistry.
authors.forename: Jay S
authors.initials: JS
authors.lastname: Hanas
authors.forename: Marvin D
authors.initials: MD
authors.lastname: Peyton
authors.forename: Megan R
authors.initials: MR
authors.lastname: Lerner
authors.forename: Stan A
authors.initials: SA
authors.lastname: Lightfoot
authors.forename: Subrato J
authors.initials: SJ
authors.lastname: Deb
authors.forename: Rushie J
authors.initials: RJ
authors.lastname: Hanas
authors.forename: Nicole T
authors.initials: NT
authors.lastname: Vu
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Kupiec
authors.forename: Donald E
authors.initials: DE
authors.lastname: Stowell
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Brackett
authors.forename: Steven M
authors.initials: SM
authors.lastname: Dubinett
authors.forename: James R
authors.initials: JR
authors.lastname: Hocker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D055613:Multiple Pulmonary Nodules / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D040901:Proteomics / Q000379:methods; D012189:Retrospective Studies; D003074:Solitary Pulmonary Nodule / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D021241:Spectrometry, Mass, Electrospray Ionization; D014057:Tomography, X-Ray Computed; D047368:Tumor Burden
chemical_list: D014408:Biomarkers, Tumor