title: Estrogen receptor mutations in breast cancer--new focus on an old target.
abstract: Recent studies have provided strong evidence for the emergence of substantial numbers of constitutively active ESR1 mutations in estrogen receptor-positive metastatic breast cancer that are undetected in primary disease. Some of these mutants remain partially sensitive to current anti-estrogen therapies but effective therapeutics targeted at them may require new approaches.
authors.affiliation: Authors' Affiliations: Breakthrough Breast Cancer Research Centre at The Institute of Cancer Research and Academic Department of Biochemistry, The Royal Marsden Hospital, London, United Kingdom.
authors.forename: Corrinne V
authors.initials: CV
authors.lastname: Segal
authors.forename: Mitch
authors.initials: M
authors.lastname: Dowsett
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D047628:Estrogen Receptor alpha / Q000235:genetics*; D005260:Female; D006801:Humans; D009154:Mutation; D009376:Neoplasms, Hormone-Dependent / Q000235:genetics*
chemical_list: D047628:Estrogen Receptor alpha