title: Efficacy of the novel topical antimicrobial agent PXL150 in a mouse model of surgical site infections.
abstract: Antimicrobial peptides have recently emerged as a promising new group to be evaluated in the therapeutic intervention of infectious diseases. This study evaluated the anti-infectious effect of the short, synthetic, broad-spectrum antimicrobial peptide PXL150 in a mouse model of staphylococcal surgical site infections. We found that administration of PXL150, formulated in an aqueous solution or in a hydroxypropyl cellulose gel, significantly reduced the bacterial counts in the wound compared with placebo treatment, warranting further investigations of the potential of this peptide as a novel local treatment of microbial infections.
authors.affiliation: Pergamum AB, Karolinska Institutet Science Park, Solna, Sweden.
authors.forename: Joakim
authors.initials: J
authors.lastname: Håkansson
authors.forename: Camilla
authors.initials: C
authors.lastname: Björn
authors.forename: Kerstin
authors.initials: K
authors.lastname: Lindgren
authors.forename: Emma
authors.initials: E
authors.lastname: Sjöström
authors.forename: Veronika
authors.initials: V
authors.lastname: Sjöstrand
authors.forename: Margit
authors.initials: M
authors.lastname: Mahlapuu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides / Q000627:therapeutic use*; D051379:Mice; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013530:Surgical Wound Infection / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D023181:Antimicrobial Cationic Peptides