title: Effects of periodontal treatment on lung function and exacerbation frequency in patients with chronic obstructive pulmonary disease and chronic periodontitis: a 2-year pilot randomized controlled trial.
abstract: OBJECTIVE
  To evaluate the direct effects of periodontal therapy in Chronic Obstructive Pulmonary Disease (COPD) patients with chronic periodontitis (CP).
  
  
  METHODS
  In a pilot randomized controlled trial, 60 COPD patients with CP were randomly assigned to receive scaling and root planing (SRP) treatment, supragingival scaling treatment, or oral hygiene instructions only with no periodontal treatment. We evaluated their periodontal indexes, respiratory function, and COPD exacerbations at baseline, 6 months, 1, and 2 years.
  
  
  RESULTS
  Compared with the control group, measurements of periodontal indexes were significantly improved in patients in two treatment groups at 6-month, 1-year, and 2-year follow-up (all p < 0.05). Overall, the means of forced expiratory volume in the first second/forced vital capacity (FEV1/FVC) and FEV1 were significantly higher in the two therapy groups compared with the control group during the follow-up (p < 0.05). In addition, the frequencies of COPD exacerbation were significantly lower in the two therapy groups than in the control group at 2-year follow-up (p < 0.05).
  
  
  CONCLUSIONS
  Our preliminary results from this pilot trial suggest that periodontal therapy in COPD patients with CP may improve lung function and decrease the frequency of COPD exacerbation.
authors.affiliation: Department of Stomatology, Beijing ChaoYang Hospital affiliated to Capital Medical University, Beijing, China.
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Song
authors.forename: Zuomin
authors.initials: Z
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D055113:Chronic Periodontitis / Q000150:complications / Q000628:therapy*; D012534:Dental Scaling / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene / Q000193:education; D017622:Periodontal Attachment Loss / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D010865:Pilot Projects; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000503:physiopathology*; D012129:Respiratory Function Tests; D016745:Root Planing / Q000379:methods; D013147:Spirometry / Q000379:methods; D016896:Treatment Outcome; D014797:Vital Capacity / Q000502:physiology
keywords: chronic obstructive pulmonary disease; chronic periodontitis; dental scaling; randomized controlled trial; root planing