title: Application of vitamin E to antagonize SWCNTs-induced exacerbation of allergic asthma.
abstract: The aggravating effects of zero-dimensional, particle-shaped nanomaterials on allergic asthma have been previously investigated, but similar possible effects of one-dimensional shaped nanomaterials have not been reported. More importantly, there are no available means to counteract the adverse nanomaterial effects to allow for their safe use. In this study, an ovalbumin (OVA)-sensitized rat asthma model was established to investigate whether single walled carbon nanotubes (SWCNTs) aggravate allergic asthma. The results showed that SWCNTs in rats exacerbated OVA-induced allergic asthma and that this exacerbation was counteracted by concurrent administration vitamin E. A mechanism involving the elimination of reactive oxygen species, downregulation of Th2 responses, reduced Ig production, and the relief of allergic asthma symptoms was proposed to explain the antagonistic effects of vitamin E. This work could provide a universal strategy to effectively protect people with allergic asthma from SWCNTs or similar nanomaterial-induced aggravating effects.
authors.affiliation: 1] Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, P. R. China [2].
authors.forename: Jinquan
authors.initials: J
authors.lastname: Li
authors.affiliation: 1] Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, P. R. China [2].
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.affiliation: CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Key Laboratory of Nuclear Analytical Techniques, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, P. R. China.
authors.forename: Hanqing
authors.initials: H
authors.lastname: Chen
authors.affiliation: Deaparment of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P. R. China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chang
authors.affiliation: Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, P. R. China.
authors.forename: Xudong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, P. R. China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wu
authors.affiliation: Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, P. R. China.
authors.forename: Chenxi
authors.initials: C
authors.lastname: Wei
authors.affiliation: Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, P. R. China.
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.affiliation: Division of Environment, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P. R. China.
authors.forename: Joseph K C
authors.initials: JK
authors.lastname: Kwan
authors.affiliation: 1] Deaparment of Chemical and Biomolecular Engineering, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P. R. China [2] Division of Environment, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P. R. China.
authors.forename: King Lun
authors.initials: KL
authors.lastname: Yeung
authors.affiliation: Institute of Health and Environmental Medicine, Dali Road, Heping District, Tianjin 300050, P. R. China.
authors.forename: Zhuge
authors.initials: Z
authors.lastname: Xi
authors.affiliation: Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715, P. R. China.
authors.forename: Zhisong
authors.initials: Z
authors.lastname: Lu
authors.affiliation: Section of Environmental Biomedicine, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Central China Normal University, Wuhan 430079, P. R. China.
authors.forename: Xu
authors.initials: X
authors.lastname: Yang
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D018450:Disease Progression; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D008168:Lung / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D008297:Male; D037742:Nanotubes, Carbon / Q000009:adverse effects*; D010047:Ovalbumin / Q000009:adverse effects; D051381:Rats; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D016207:Cytokines; D007074:Immunoglobulin G; D037742:Nanotubes, Carbon; D014810:Vitamin E; D007073:Immunoglobulin E; D010047:Ovalbumin