title: Bone's dark side: mutated osteoblasts implicated in leukemia.
abstract: Bone-lining osteolineage cells were previously implicated as contributors to hematological disorders and malignancies. A recent report in Nature now demonstrates that a specific mutation in mouse collagen-expressing osteoblastic cells leads to MDS and AML with 100% penetrance and is associated with strikingly similar findings in human patients.
authors.affiliation: 1] Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA [2] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA [3] Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
authors.forename: Amir
authors.initials: A
authors.lastname: Schajnovitz
authors.affiliation: 1] Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA [2] Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA [3] Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
authors.forename: David T
authors.initials: DT
authors.lastname: Scadden
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology*; D008297:Male; D009154:Mutation / Q000235:genetics*; D010006:Osteoblasts / Q000378:metabolism*; D051176:beta Catenin / Q000235:genetics* / Q000378:metabolism*
chemical_list: D051176:beta Catenin