title: Histamine regulation of pancreatitis and pancreatic cancer: a review of recent findings.
abstract: The pancreas is a dynamic organ that performs a multitude of functions within the body. Diseases that target the pancreas, like pancreatitis and pancreatic cancer, are devastating and often fatal to the suffering patient. Histamine and histamine receptors (H1-H4HRs) have been found to play a critical role in biliary diseases. Accordingly, the biliary tract and the pancreas share similarities with regards to morphological, phenotypical and functional features and disease progression, studies related the role of H1-H4HRs in pancreatic diseases are important. In this review, we have highlighted the role that histamine, histidine decarboxylase (HDC), histamine receptors and mast cells (the main source of histamine in the body) play during both pancreatitis and pancreatic cancer. The objective of the review is to demonstrate that histamine and histamine signaling may be a potential therapeutic avenue towards treatment strategies for pancreatic diseases.
authors.affiliation: Medicine, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA.
authors.forename: Taylor
authors.initials: T
authors.lastname: Francis
authors.affiliation: Research, Central Texas Veteran's Health Care System, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA ; Scott & White Digestive Disease Research Center, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA.
authors.forename: Allyson
authors.initials: A
authors.lastname: Graf
authors.affiliation: Scott & White Digestive Disease Research Center, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA.
authors.forename: Kyle
authors.initials: K
authors.lastname: Hodges
authors.affiliation: Scott & White Digestive Disease Research Center, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Kennedy
authors.affiliation: Scott & White Digestive Disease Research Center, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Hargrove
authors.affiliation: Scott & White Digestive Disease Research Center, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA.
authors.forename: Mattie
authors.initials: M
authors.lastname: Price
authors.affiliation: Scott & White Digestive Disease Research Center, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA.
authors.forename: Kate
authors.initials: K
authors.lastname: Kearney
authors.affiliation: Medicine, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA ; Research, Central Texas Veteran's Health Care System, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA ; Scott & White Digestive Disease Research Center, Scott and White Healthcare, Texas A&M HSC, Temple, TX, USA.
authors.forename: Heather
authors.initials: H
authors.lastname: Francis
keywords: Histamine; pancreas; pancreatic cancer; pancreatitis