title: Using yeast to model calcium-related diseases: example of the Hailey-Hailey disease.
abstract: Cross-complementation studies offer the possibility to overcome limitations imposed by the inherent complexity of multicellular organisms in the study of human diseases, by taking advantage of simpler model organisms like the budding yeast Saccharomyces cerevisiae. This review deals with, (1) the use of S. cerevisiae as a model organism to study human diseases, (2) yeast-based screening systems for the detection of disease modifiers, (3) Hailey-Hailey as an example of a calcium-related disease, and (4) the presentation of a yeast-based model to search for chemical modifiers of Hailey-Hailey disease. The preliminary experimental data presented and discussed here show that it is possible to use yeast as a model system for Hailey-Hailey disease and suggest that in all likelihood, yeast has the potential to reveal candidate drugs for the treatment of this disorder. This article is part of a Special Issue entitled: Calcium signaling in health and disease. Guest Editors: Geert Bultynck, Jacques Haiech, Claus W. Heizmann, Joachim Krebs, and Marc Moreau.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale UMR 1078; Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé; Etablissement Français du Sang (EFS) Bretagne; CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, Brest F-29200, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Voisset
authors.affiliation: Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), University of Seville, Avd. Americo Vespucio SN, 41092 Sevilla, Spain.
authors.forename: Néstor
authors.initials: N
authors.lastname: García-Rodríguez
authors.affiliation: Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), University of Seville, Avd. Americo Vespucio SN, 41092 Sevilla, Spain.
authors.forename: April
authors.initials: A
authors.lastname: Birkmire
authors.affiliation: Institut National de la Santé et de la Recherche Médicale UMR 1078; Université de Bretagne Occidentale, Faculté de Médecine et des Sciences de la Santé; Etablissement Français du Sang (EFS) Bretagne; CHRU Brest, Hôpital Morvan, Laboratoire de Génétique Moléculaire, Brest F-29200, France. Electronic address: marc.blondel@univ-brest.fr.
authors.forename: Marc
authors.initials: M
authors.lastname: Blondel
authors.affiliation: Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER), University of Seville, Avd. Americo Vespucio SN, 41092 Sevilla, Spain.
authors.forename: Ralf Erik
authors.initials: RE
authors.lastname: Wellinger
mesh_terms: D000279:Administration, Cutaneous; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D000252:Calcium-Transporting ATPases / Q000172:deficiency / Q000235:genetics*; D003879:Dermatologic Agents / Q000494:pharmacology; D004100:Dihydroxycholecalciferols / Q000494:pharmacology; D015870:Gene Expression; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008954:Models, Biological; D018832:Molecular Chaperones / Q000235:genetics*; D009154:Mutation; D016506:Pemphigus, Benign Familial / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D003879:Dermatologic Agents; D004100:Dihydroxycholecalciferols; D018832:Molecular Chaperones; C101767:SSC1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C023850:1 alpha,24-dihydroxyvitamin D3; C403624:ATP2C1 protein, human; D000252:Calcium-Transporting ATPases; D002118:Calcium
keywords: ATP2C1/PMR1; Budding yeast Saccharomyces cerevisiae; Calcium; Hailey–Hailey disease; Yeast models for human diseases; Yeast-based drug screening assay