title: Why do we have Purkinje fibers deep in our heart?
abstract: Purkinje fibers were the first discovered component of the cardiac conduction system. Originally described in sheep in 1839 as pale subendocardial cells, they were found to be present, although with different morphology, in all mammalian and avian hearts. Here we review differences in their appearance and extent in different species, summarize the current state of knowledge of their function, and provide an update on markers for these cells. Special emphasis is given to popular model species and human anatomy.
authors.affiliation: Department of Cardiovascular Morphogenesis, Institute of Physiology Academy of Sciences of the Czech Republic, Prague, Czech Republic. dsedmera@biomed.cas.cz.
authors.forename: D
authors.initials: D
authors.lastname: Sedmera
authors.forename: R G
authors.initials: RG
authors.lastname: Gourdie
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D056966:Excitation Contraction Coupling / Q000502:physiology*; D006801:Humans; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D011690:Purkinje Fibers / Q000166:cytology* / Q000502:physiology*