title: Doing the math: How yeast cells maintain their peroxisome populations.
abstract: The formation of membrane contact sites between cellular organelles is required for proper organelle communication and maintenance in the compartmentalized eukaryotic cell. We recently identified a tether that links peroxisomes to the cortical ER in the yeast, Saccharomyces cerevisiae. The tether is made up of the peroxisome biogenic protein Pex3p and the peroxisome inheritance factor Inp1p, and is formed by Inp1p-mediated linkage of ER-bound Pex3p and peroxisomal Pex3p. Here we discuss how this tether is fine-tuned to ensure that peroxisomes are stably maintained over generations of yeast cells.
authors.affiliation: Department of Cell Biology; University of Alberta; Edmonton, AB Canada.
authors.forename: Barbara
authors.initials: B
authors.lastname: Knoblach
authors.affiliation: Department of Cell Biology; University of Alberta; Edmonton, AB Canada.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Rachubinski
keywords: endoplasmic reticulum; high resolution microscopy; membrane contact site; molecular motor; organelle inheritance; organelle tether; peroxisome