title: Ebola virus vaccines: an overview of current approaches.
abstract: Ebola hemorrhagic fever is one of the most fatal viral diseases worldwide affecting humans and nonhuman primates. Although infections only occur frequently in Central Africa, the virus has the potential to spread globally and is classified as a category A pathogen that could be misused as a bioterrorism agent. As of today there is no vaccine or treatment licensed to counteract Ebola virus infections. DNA, subunit and several viral vector approaches, replicating and non-replicating, have been tested as potential vaccine platforms and their protective efficacy has been evaluated in nonhuman primate models for Ebola virus infections, which closely resemble disease progression in humans. Though these vaccine platforms seem to confer protection through different mechanisms, several of them are efficacious against lethal disease in nonhuman primates attesting that vaccination against Ebola virus infections is feasible.
authors.affiliation: Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840, MT, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Marzi
authors.forename: Heinz
authors.initials: H
authors.lastname: Feldmann
mesh_terms: D000350:Africa, Central / Q000453:epidemiology; D000818:Animals; D004195:Disease Models, Animal; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D046129:Ebola Vaccines / Q000276:immunology* / Q000302:isolation & purification*; D029043:Ebolavirus / Q000276:immunology*; D019142:Hemorrhagic Fever, Ebola / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control* / Q000635:transmission; D006801:Humans; D011323:Primates; D016019:Survival Analysis
chemical_list: D046129:Ebola Vaccines