title: Coaxiality of Foxb1- and parvalbumin-expressing neurons in the lateral hypothalamic PV1-nucleus.
abstract: In the ventrolateral hypothalamus, the PV1-nucleus is defined by its population of parvalbumin-expressing neurons. During embryogenesis, the ventrolateral hypothalamus is colonized also by Foxb1-expressing neurons. In adult Foxb1-EGFP mice, many immunofluorescent neurons were found within the region that is occupied by the PV1-nucleus. They formed a cloud around the axial cord of the parvalbumin-immunopositive cells, which they greatly outnumber (3:1). Only a small proportion of the neurons in the PV1-nucleus co-expressed both parvalbumin and Foxb1. In the light of these findings, a redesignation of this lateral hypothalamic structure as the PV1-Foxb1 nucleus would more accurately reflect its specific biochemical properties.
authors.affiliation: Anatomy Unit, Department of Medicine and Program in Neuroscience, University of Fribourg, CH-1700 Fribourg, Switzerland.
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bilella
authors.affiliation: Institute of Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Alvarez-Bolado
authors.affiliation: Anatomy Unit, Department of Medicine and Program in Neuroscience, University of Fribourg, CH-1700 Fribourg, Switzerland. Electronic address: marco.celio@unifr.ch.
authors.forename: Marco R
authors.initials: MR
authors.lastname: Celio
mesh_terms: D000818:Animals; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D007026:Hypothalamic Area, Lateral / Q000378:metabolism*; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism*; D010320:Parvalbumins / Q000235:genetics / Q000378:metabolism*
chemical_list: D051858:Forkhead Transcription Factors; C491332:Foxb1 protein, mouse; D010320:Parvalbumins; C485184:enhanced green fluorescent protein; D049452:Green Fluorescent Proteins
keywords: Hypothalamic development; Immunohistochemistry; Medial forebrain bundle; Periaqueductal grey; Stereology