title: Dendritic cell lectin-targeting sentinel-like unimolecular glycoconjugates to release an anti-HIV drug.
abstract: A series of cyclodextrin-based glycoconjugates, including glycoclusters and star glycopolymers, were synthesized via combination of CuAAC Huisgen coupling and copper-mediated living radical polymerization. These glycoconjugates showed high affinity binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations. The star block glycopolymers showed high loading capacity of hydrophobic anticancer and anti-HIV drugs, indicating promising applications in HIV-therapeutic and smart drug delivery.
authors.affiliation: Department of Chemistry, University of Warwick , CV4 7AL Coventry, United Kingdom.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Lu
authors.initials: L
authors.lastname: Su
authors.forename: Jennifer
authors.initials: J
authors.lastname: Collins
authors.forename: Guosong
authors.initials: G
authors.lastname: Chen
authors.forename: Russell
authors.initials: R
authors.lastname: Wallis
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Mitchell
authors.forename: David M
authors.initials: DM
authors.lastname: Haddleton
authors.forename: C Remzi
authors.initials: CR
authors.lastname: Becer
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites / Q000187:drug effects; D003505:Cyclodextrins / Q000737:chemistry*; D003713:Dendritic Cells / Q000187:drug effects; D006001:Glycoconjugates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects*; D015699:HIV Envelope Protein gp120 / Q000037:antagonists & inhibitors*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D058105:Polymerization; D013329:Structure-Activity Relationship
chemical_list: D019380:Anti-HIV Agents; D003505:Cyclodextrins; D006001:Glycoconjugates; D015699:HIV Envelope Protein gp120