title: cis-1-Oxo-heterocyclyl-4-amido cyclohexane derivatives as NPY5 receptor antagonists.
abstract: The NPY5 receptor binding and pharmacokinetic properties of a novel series of cis-1-oxo-heterocyclyl-4-amido-cyclohexane derivatives are described.
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: James Ford
authors.initials: JF
authors.lastname: Burns
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Chien-An
authors.initials: CA
authors.lastname: Chen
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Dario
authors.initials: D
authors.lastname: Doller
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Eman
authors.initials: E
authors.lastname: Edelmenky
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Jiang
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA. Electronic address: johnptrsn74@gmail.com.
authors.forename: John M
authors.initials: JM
authors.lastname: Peterson
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Sabio
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Jessie
authors.initials: J
authors.lastname: Weiss
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: White
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Lingyun
authors.initials: L
authors.lastname: Wu
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Rajinder
authors.initials: R
authors.lastname: Bhardwaj
authors.affiliation: Department of Chemical and Pharmacokinetic Sciences, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Gamini
authors.initials: G
authors.lastname: Chandrasena
authors.affiliation: Department of Biological Research, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Noel J
authors.initials: NJ
authors.lastname: Boyle
authors.affiliation: Department of Biological Research, Lundbeck Research USA, 215 College Road, Paramus, NJ 07652, USA.
authors.forename: Xinyan
authors.initials: X
authors.lastname: Huang
mesh_terms: D000818:Animals; D003510:Cyclohexanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D007536:Isomerism; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D003510:Cyclohexanes; D017476:Receptors, Neuropeptide Y; C100568:neuropeptide Y5 receptor; C506365:Cyclohexane
keywords: Neuropeptide Y5 receptor antagonist