title: Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors.
abstract: The pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive interactions involving erythrocytes, leukocytes, and the endothelium. Selectins are expressed by leukocytes, platelets, and the endothelium, among other tissues. They contribute to a wide variety of physiologically important cell-cell interactions, including adhesion of all types of blood cells to the endothelium. In vitro, in vivo, and early-phase clinical studies suggest that E-selectin and pan-selectin inhibitors may be promising new therapeutic agents for the treatment of vasoocclusion in sickle cell disease.
authors.affiliation: Division of Hematology, Department of Medicine and Duke Comprehensive Sickle Cell Center, Duke University Medical Center, Box 2615, Durham, NC 27710, USA. Electronic address: marilyn.telen@duke.edu.
authors.forename: Marilyn J
authors.initials: MJ
authors.lastname: Telen
mesh_terms: D000755:Anemia, Sickle Cell / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D001157:Arterial Occlusive Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D002448:Cell Adhesion / Q000187:drug effects; D002450:Cell Communication / Q000187:drug effects; D019040:E-Selectin / Q000378:metabolism*; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006017:Glycolipids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D019041:L-Selectin / Q000378:metabolism*
chemical_list: D019040:E-Selectin; D006017:Glycolipids; D019041:L-Selectin; C553182:rivipansel
keywords: Adhesion; Endothelium; Integrins; Selectins; Sickle cell disease