title: Acquired factor V inhibitor in a patient with mantle cell lymphoma presenting with hematuria followed by thrombosis: a case report.
abstract: Acquired factor V inhibitor is a rare hemostatic disorder that presents with hemorrhagic manifestations in the vast majority of patients. Factor V inhibitor may develop through a variety of mechanisms involving development of alloantibodies or autoantibodies specific to Factor V. Autoantibodies, in particular, have been reported in a number of conditions. In this report, we describe a case of acquired factor V inhibitor in a patient with mantle cell lymphoma who presented with hematuria. Seven weeks after diagnosis and successful management, the patient developed deep vein thrombosis in the right lower extremity. The patient's factor V levels were normalized, and the inhibitor was successfully eradicated using corticosteroids. Here, we discuss this rare disorder, its unusual manifestation, and provide a mini-review of the current literature regarding factor V inhibitors.
authors.affiliation: King Faisal specialist hospital and research centre, Saudi Arabia ; Division of Hematology, Department of Internal Medicine, Queen's University, Kingston, Ontario, Canada.
authors.forename: Naif I
authors.initials: NI
authors.lastname: Aljohani
authors.affiliation: Division of Hematology, Department of Internal Medicine, Queen's University, Kingston, Ontario, Canada.
authors.forename: John H
authors.initials: JH
authors.lastname: Matthews
keywords: acquired bleeding disorders; acquired factor V inhibitor; blood coagulation disorders; factor V deficiency