title: Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents.
abstract: (-)-Massoialactone, an α,β-unsaturated δ-lactone isolated from Cryptocarya massoia, and five analogues were synthesized and their antiproliferative and anti-inflammatory activities were evaluated. The lactones were able to mimic the "core" functional group required for the biological activity of their parent natural compounds suggesting that substantially altered analogues may retain their properties.
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil.
authors.forename: Maria E S B
authors.initials: ME
authors.lastname: Barros
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil.
authors.forename: Juliano C R
authors.initials: JC
authors.lastname: Freitas
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil.
authors.forename: Juliana M
authors.initials: JM
authors.lastname: Oliveira
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil.
authors.forename: Carlos H B
authors.initials: CH
authors.lastname: da Cruz
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Fisiologia e Farmacologia, CCB, Cidade Universitária, Recife, PE, Brazil.
authors.forename: Paulo B N
authors.initials: PB
authors.lastname: da Silva
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Fisiologia e Farmacologia, CCB, Cidade Universitária, Recife, PE, Brazil.
authors.forename: Larissa C C
authors.initials: LC
authors.lastname: de Araújo
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Fisiologia e Farmacologia, CCB, Cidade Universitária, Recife, PE, Brazil.
authors.forename: Gardenia C G
authors.initials: GC
authors.lastname: Militão
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Antibióticos, Cidade Universitária, Recife, PE, Brazil.
authors.forename: Teresinha G
authors.initials: TG
authors.lastname: da Silva
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil.
authors.forename: Roberta A
authors.initials: RA
authors.lastname: Oliveira
authors.affiliation: Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil. Electronic address: paulo.menezes@pq.cnpq.br.
authors.forename: Paulo H
authors.initials: PH
authors.lastname: Menezes
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008807:Mice, Inbred BALB C; D011753:Pyrones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: C000593212:6-(phenoxymethyl)-5,6-dihydro-2H-pyran-2-one; D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D011753:Pyrones
keywords: Anti-inflammatory activity; Antitumoral activity; Lactones; Massoialactone; Tellurides