title: Recent advances in molecular imaging of premalignant gastrointestinal lesions and future application for early detection of barrett esophagus.
abstract: Recent advances in optical molecular imaging allow identification of morphologic and biochemical changes in tissues associated with gastrointestinal (GI) premalignant lesions earlier and in real-time. This focused review series introduces high-resolution imaging modalities that are being evaluated preclinically and clinically for the detection of early GI cancers, especially Barrett esophagus and esophageal adenocarcinoma. Although narrow band imaging, autofluorescence imaging, and chromoendoscopy are currently applied for this purpose in the clinic, further adoptions of probe-based confocal laser endomicroscopy, high-resolution microendoscopy, optical coherence tomography, and metabolomic imaging, as well as imaging mass spectrometry, will lead to detection at the earliest and will guide predictions of the clinical course in the near future in a manner that is beyond current advancements in optical imaging. In this review article, the readers will be introduced to sufficient information regarding this matter with which to enjoy this new era of high technology and to confront science in the field of molecular medical imaging.
authors.affiliation: Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors.forename: Kwang Hyun
authors.initials: KH
authors.lastname: Ko
authors.affiliation: Gachon University College of Pharmacy, Incheon, Korea.
authors.forename: Na Young
authors.initials: NY
authors.lastname: Han
authors.affiliation: Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors.forename: Chang Il
authors.initials: CI
authors.lastname: Kwon
authors.affiliation: Gachon University College of Pharmacy, Incheon, Korea.
authors.forename: Hoo Keun
authors.initials: HK
authors.lastname: Lee
authors.affiliation: Cancer Prevention Research Center, CHA University, Seoul, Korea.
authors.forename: Jong Min
authors.initials: JM
authors.lastname: Park
authors.affiliation: Cancer Prevention Research Center, CHA University, Seoul, Korea.
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Kim
authors.affiliation: Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
authors.forename: Ki Baik
authors.initials: KB
authors.lastname: Hahm
keywords: Barrett esophagus; Biological markers; Gastrointestinal premalignant lesions; Imaging mass spectrometry