title: Association of Rho-kinase 1 (ROCK1) gene polymorphisms with Behçet's disease.
abstract: OBJECTIVE
  Behçet's disease (BD) is a chronic inflammatory vasculitis presenting with flares and silent periods usually between 15 and 40 years of age. The aim of this study was to evaluate the possible association between Rho-kinase 1 (ROCK1) gene polymorphisms and patients with BD in a Turkish population.
  
  
  METHODS
  A total of 192 BD patients and 255 healthy controls of similar age and sex were enrolled in this study. Polymorphisms were analyzed in genomic DNA using a BioMark HD dynamic array system.
  
  
  RESULTS
  In the presence of CC genotype for rs73963110, CT genotype for rs111874856 (Val355Ile), and TC genotype for rs112130712 (Lys1054Arg) polymorphisms, the risk of BD increased 12.13-, 15.05-, and 16.28-fold, respectively (p < 0.0001). There was a lower frequency of the GA genotype of the rs112108028 (Pro1164Leu) polymorphisms in BD (10.3 %) compared with controls (39.7 %; p < 0.0001). Marked associations between these polymorphisms and the manifestations of BD were recorded.
  
  
  CONCLUSIONS
  This is the first study to show that ROCK1 gene polymorphisms may have a significant impact on susceptibility to BD.
authors.affiliation: Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, University Road, 27310, Sehitkamil, Gaziantep, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Oguz
authors.forename: Abdullah Tuncay
authors.initials: AT
authors.lastname: Demiryürek
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Pehlivan
authors.forename: Bünyamin
authors.initials: B
authors.lastname: Kisacik
authors.forename: Esma
authors.initials: E
authors.lastname: Ozkara
authors.forename: Serdar
authors.initials: S
authors.lastname: Oztuzcu
authors.forename: Belgin
authors.initials: B
authors.lastname: Alasehirli
authors.forename: Ahmet Mesut
authors.initials: AM
authors.lastname: Onat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001528:Behcet Syndrome / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D055815:Young Adult; D054460:rho-Associated Kinases / Q000235:genetics*
chemical_list: C515851:ROCK1 protein, human; D054460:rho-Associated Kinases