title: Increased coronary intervention rate among diabetic patients with poor glycaemic control: a cross-sectional study.
abstract: The relationship between glycaemic control and coronary artery disease (CAD) in type 2 diabetes mellitus (T2DM) is controversial. In the current cross-sectional study, we addressed the relationship between Hemoglobin A1c (HbA1c) values and the need for revascularization among diabetic patients undergoing coronary angiography. A total of 301 consecutive patients with known T2DM (age 61.8±10.1 years, 46.2 % women) requiring coronary angiography due to CAD symptoms were included. T2DM patients were categorized into two groups based on their HbA1c values: 93 (30.9%) diabetics with good glycaemic control (HbA1c≤7 %), and 208 (69.1%) diabetics with poor glycaemic control (HbA1c>7 %). A total of 123 patients (40.9%) required revascularization. The revascularization rate was 28.0% among T2DM patients with good glycaemic control and 46.6% among T2DM patients with poor glycaemic control, respectively (p=0.002). In a logistic regression analysis, the need for revascularization was predicted by poor glycaemic control (Odds Ratio [OR] 2.26, 95% Confidence Interval [CI] 1.32-3.82; p=0.003) adjusted for age, gender, Body-Mass-Index and diabetes duration. Moreover, there was a linear relationship between HbA1c values and number of affected coronary arteries (r= 0.169; p=0.003). Our data suggest that there is a close association between poor glycaemic control and increased revascularization rate in T2DM, which should be considered in primary and secondary prevention models.
authors.affiliation: Department of Cardiology, 29 Mayıs Hospital, Dikmen Caddesi, No:312, 06460 Ankara, Turkey.
authors.forename: Süha
authors.initials: S
authors.lastname: Çetin
authors.affiliation: Department of Internal Medicine, School of Medicine, Gazi University, Emniyet Mahallesi, 06560 Ankara, Turkey.
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Öztürk
authors.affiliation: Department of Cardiology, 29 Mayıs Hospital, Dikmen Caddesi, No:312, 06460 Ankara, Turkey.
authors.forename: Nadir
authors.initials: N
authors.lastname: Barındık
authors.affiliation: Department of Cardiology, 29 Mayıs Hospital, Dikmen Caddesi, No:312, 06460 Ankara, Turkey.
authors.forename: Ersin
authors.initials: E
authors.lastname: İmren
authors.affiliation: Department of Molecular and Clinical Medicine/Cardiology, Sahlgrenska Academy, University of Gothenborg, Medicinaregaten 3, 40530 Gothenborg, Sweden.
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Peker
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents