title: [The peculiarities of the thymus and cranial mesenteric lymph node structure in the newborn rats after prenatal exposure to ethanol].
abstract: The structural peculiarities of the thymus and cranial mesenteric lymph nodes (LN) were examined in 72 neonatal rats born to females, exposed to 15% ethanol solution during pregnancy (n = 34), as well as both during pregnancy and for 1 month preceding it (n = 38). 44 neonatal rats born to intact females, served as a control group. It was shown that the exposure of female rats to ethanol only during pregnancy resulted in more pronounced changes in the mesenteric LN of the offspring than in the thymus. These included the reduction of LN number, cross-sectional area, lymphoid cell relative content, the suppression of mitotic activity, increased reticular cell content and macrophage activity. Pre-gravid ethanol intoxication of females for 1 month in combination with ethanol exposure during pregnancy was shown to have greater effect on the thymus morphogenesis in the offspring. This was manifested by the decrease of its absolute and relative mass, proliferative activity, increase of cell death, appearance of the microcirculatory and dysplastic changes.
authors.forename: P V
authors.initials: PV
authors.lastname: Pugach
authors.forename: S V
authors.initials: SV
authors.lastname: Kruglov
authors.forename: N R
authors.initials: NR
authors.lastname: Karelina
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity; D005260:Female; D008196:Lymph / Q000187:drug effects*; D008198:Lymph Nodes / Q000187:drug effects* / Q000473:pathology; D008643:Mesentery / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects*
chemical_list: D000431:Ethanol