title: Gene expression analysis in RA: towards personalized medicine.
abstract: Gene expression has recently been at the forefront of advance in personalized medicine, notably in the field of cancer and transplantation, providing a rational for a similar approach in rheumatoid arthritis (RA). RA is a prototypic inflammatory autoimmune disease with a poorly understood etiopathogenesis. Inflammation is the main feature of RA; however, many biological processes are involved at different stages of the disease. Gene expression signatures offer management tools to meet the current needs for personalization of RA patients' care. This review analyses currently available information with respect to RA diagnostic, prognostic and prediction of response to therapy with a view to highlight the abundance of data, whose comparison is often inconclusive due to the mixed use of material source, experimental methodologies and analysis tools, reinforcing the need for harmonization if gene expression signatures are to become a useful clinical tool in personalized medicine for RA patients.
authors.affiliation: Leeds Institute of Rheumatic and Musculoskeletal Medicine and Leeds Musculoskeletal Biomediacal Research Unit, The University of Leeds, Leeds, UK.
authors.forename: A N
authors.initials: AN
authors.lastname: Burska
authors.affiliation: TcLand Expression, Huningue, France.
authors.forename: K
authors.initials: K
authors.lastname: Roget
authors.affiliation: Department of Pathology and Rheumatology, Inflammatory Disease Profiling Unit, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Blits
authors.affiliation: School of law, The University of Leeds, Leeds, UK.
authors.forename: L
authors.initials: L
authors.lastname: Soto Gomez
authors.affiliation: Department of Rheumatology Research and Advanced Therapeutics, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands.
authors.forename: F
authors.initials: F
authors.lastname: van de Loo
authors.affiliation: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.
authors.forename: L D
authors.initials: LD
authors.lastname: Hazelwood
authors.affiliation: Department of Pathology and Rheumatology, Inflammatory Disease Profiling Unit, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: C L
authors.initials: CL
authors.lastname: Verweij
authors.affiliation: Janssen Research and Development, High Wycombe, UK.
authors.forename: A
authors.identifier: 0000000318291179
authors.initials: A
authors.lastname: Rowe
authors.affiliation: Molecular Medicine and Human Genetics Section, Department of Medicine, University of Crete, Heraklion, Greece.
authors.forename: G N
authors.initials: GN
authors.lastname: Goulielmos
authors.affiliation: Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: L G M
authors.initials: LG
authors.lastname: van Baarsen
authors.affiliation: Leeds Institute of Rheumatic and Musculoskeletal Medicine and Leeds Musculoskeletal Biomediacal Research Unit, The University of Leeds, Leeds, UK.
authors.forename: F
authors.initials: F
authors.lastname: Ponchel
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D005786:Gene Expression Regulation; D006801:Humans; D057285:Precision Medicine; D011379:Prognosis