title: Association between hepatitis E and neurological disorders: two case studies and literature review.
abstract: Hepatitis E (HEV) is an emerging disease in our developed countries, but is not routinely tested for in case of liver cytolysis. However, a growing number of extra-hepatic manifestations of HEV infection associated with acute hepatitis are reported. In this article, we discuss two cases of HEV with neurological symptoms, one with encephalitis, and the other with Parsonage Turner syndrome. All these disorders appeared concomitantly with liver cytolysis and disappeared quickly, following the viral kinetics. Only twenty cases of neurological manifestation of HEV have been described before. The use of HEV serology in patients with concurrent liver cytolysis and neurological symptoms has to be improved.
authors.affiliation: Service de médecine interne, CHU A. Michallon, 38700 La Tronche, France. Electronic address: aderoux@chu-grenoble.fr.
authors.forename: A
authors.initials: A
authors.lastname: Deroux
authors.affiliation: Service de maladies infectieuses, CHU A. Michallon, 38700 La Tronche, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Brion
authors.affiliation: Service de maladies infectieuses, CHU A. Michallon, 38700 La Tronche, France.
authors.forename: L
authors.initials: L
authors.lastname: Hyerle
authors.affiliation: Service de médecine interne, CHU A. Michallon, 38700 La Tronche, France.
authors.forename: A
authors.initials: A
authors.lastname: Belbezier
authors.affiliation: Service de neurologie, CHU A. Michallon, 38700 La Tronche, France.
authors.forename: M
authors.initials: M
authors.lastname: Vaillant
authors.affiliation: Service de maladies infectieuses, CHU A. Michallon, 38700 La Tronche, France.
authors.forename: E
authors.initials: E
authors.lastname: Mosnier
authors.affiliation: Service de virologie, CHU A. Michallon, 38700 La Tronche, France.
authors.forename: S
authors.initials: S
authors.lastname: Larrat
authors.affiliation: Service de virologie, CHU A. Michallon, 38700 La Tronche, France.
authors.forename: P
authors.initials: P
authors.lastname: Morand
authors.affiliation: Service de neurologie, CHU A. Michallon, 38700 La Tronche, France.
authors.forename: P
authors.initials: P
authors.lastname: Pavese
mesh_terms: D000328:Adult; D020968:Brachial Plexus Neuritis / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D018792:Encephalitis, Viral / Q000175:diagnosis* / Q000209:etiology* / Q000473:pathology; D016751:Hepatitis E / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology; D016752:Hepatitis E virus / Q000302:isolation & purification; D006801:Humans; D008297:Male; D014766:Viremia
keywords: Encephalitis; Hepatitis E; Neurological disorders; Parsonage-Turner; Viral hepatitis