title: Novel regulators of spermatogenesis.
abstract: Spermatogenesis is a multistep process that supports the production of millions of sperm daily. Understanding of the molecular mechanisms that regulate spermatogenesis has been a major focus for decades. Yet, the regulators involved in different cellular processes of spermatogenesis remain largely unknown. Human diseases that result in defective spermatogenesis have provided hints on the molecular mechanisms regulating this process. In this review, we have summarized recent findings on the function and signaling mechanisms of several genes that are known to be associated with disease or pathological processes, including CFTR, CD147, YWK-II and CT genes, and discuss their potential roles in regulating different processes of spermatogenesis.
authors.affiliation: Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Kin Lam
authors.initials: KL
authors.lastname: Fok
authors.affiliation: Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.affiliation: Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
authors.forename: Ye Chun
authors.initials: YC
authors.lastname: Ruan
authors.affiliation: Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong. Electronic address: hsiaocchan@cuhk.edu.hk.
authors.forename: Hsiao Chang
authors.initials: HC
authors.lastname: Chan
mesh_terms: D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D051926:Basigin / Q000235:genetics / Q000378:metabolism; D002465:Cell Movement / Q000235:genetics; D003456:Cryptorchidism / Q000235:genetics; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D012708:Sertoli Cells / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction; D013091:Spermatogenesis / Q000502:physiology*; D013094:Spermatozoa / Q000166:cytology*
chemical_list: C084104:APLP2 protein, human; D016564:Amyloid beta-Protein Precursor; C497886:BSG protein, human; C505032:CFTR protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C539319:TEX101 protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D051926:Basigin; D017346:Protein Serine-Threonine Kinases; C000592903:STK31 protein, human
keywords: CD147; CFTR; NYD-SP8; STK31; Spermatogenesis; YWK-II