title: Effect of vitamin D on postoperative adhesion formation in a rat uterine horn adhesion model.
abstract: OBJECTIVE
  To determine the role of vitamin D for preventing or reducing postoperative adhesions.
  
  
  METHODS
  The uterine horn adhesion model was carried out in 24 female Wistar rats. The animals were randomized into 4 groups: (1) control, (2) Ringer's lactate, (3) olive oil, and (4) vitamin D. Adhesion grade and histologic findings of adhesion-carrying tissues were evaluated, and groups were compared according to these parameters.
  
  
  RESULTS
  Rats treated with vitamin D had less adhesion and lower inflammation grade when compared to the control and Ringer's lactate groups, and the results were statistically significant (p < 0.05). On the other hand, no difference was detected between the groups according to the fibrosis score.
  
  
  CONCLUSIONS
  Vitamin D decreased postsurgical adhesion scores by both visual scores and histologic analyses in a rat model. Further experimental and clinical trials are required to confirm these results.
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey. saynur77@yahoo.com
authors.forename: Saynur Sarici
authors.initials: SS
authors.lastname: Yilmaz
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey.
authors.forename: Deniz
authors.initials: D
authors.lastname: Hizli
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey.
authors.forename: Engin
authors.initials: E
authors.lastname: Yilmaz
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey.
authors.forename: Ozlem Gün
authors.initials: OG
authors.lastname: Eryilmaz
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Hizli
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health and Education Hospital, Ankara, Turkey.
authors.forename: Hacer
authors.initials: H
authors.lastname: Haltaş
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005355:Fibrosis / Q000473:pathology; D007249:Inflammation / Q000473:pathology; D007552:Isotonic Solutions / Q000008:administration & dosage; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D000077325:Ringer's Lactate; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*; D014591:Uterine Diseases / Q000473:pathology / Q000517:prevention & control*; D014599:Uterus / Q000473:pathology / Q000601:surgery; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D007552:Isotonic Solutions; D000069463:Olive Oil; D010938:Plant Oils; D000077325:Ringer's Lactate; D014807:Vitamin D