title: Enhanced depth imaging optical coherence tomography of the choroid in migraine patients: implications for the association of migraine and glaucoma.
abstract: OBJECTIVE
  To compare the choroidal thickness measurements obtained during the attack period and during the pain-free interval in migraine patients using enhanced depth imaging optical coherence tomography (OCT).
  
  
  METHODS
  58 eyes of 29 subjects with a diagnosis of migraine with or without aura were enrolled in this observational, cross-sectional study. Two OCT scans were performed for each patient, one during the peak period of the migraine attack and the other during the headache-free interval, using the enhanced depth imaging mode. Choroidal thicknesses were measured at the fovea, at three locations nasal and at three locations temporal to the fovea at 500 μm intervals.
  
  
  RESULTS
  In patients with unilateral headaches, the choroidal thickness measurements obtained during the attack period were significantly increased only in the eyes on the headache side (p<0.001) compared to basal levels. At the fovea, the choroidal thickness measured in the pain-free interval was 373.45 ± 76.47 μm (mean ± SD), which increased to 408.80 ± 77.70 μm during the attack period (p<0.001). When the choroidal thickness measurements of patients with bilateral headaches were compared to basal levels, a statistically significant increase was observed at five out of the seven measured points in the right eyes (p<0.05) and at all seven measured points in the left eyes (p<0.05).
  
  
  CONCLUSIONS
  Choroidal thickness was found to be significantly increased in migraine patients during the attack period when compared to basal levels. The possible implications of this finding on the association between migraine and glaucoma are discussed.
authors.affiliation: Department of Ophthalmology, Mevlana University School of Medicine, Konya, Turkey.
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Dadaci
authors.affiliation: Department of Neurology, Mevlana University School of Medicine, Konya, Turkey.
authors.forename: Fatma
authors.initials: F
authors.lastname: Doganay
authors.affiliation: Department of Ophthalmology, Mevlana University School of Medicine, Konya, Turkey.
authors.forename: Nursen
authors.initials: N
authors.lastname: Oncel Acir
authors.affiliation: Department of Neurology, Konya Research and Training Hospital, Konya, Turkey.
authors.forename: Hacer Doganay
authors.initials: HD
authors.lastname: Aydin
authors.affiliation: Department of Ophthalmology, Mevlana University School of Medicine, Konya, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Borazan
mesh_terms: D000293:Adolescent; D000328:Adult; D002829:Choroid / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000150:complications*; D020326:Migraine without Aura / Q000150:complications*; D041623:Tomography, Optical Coherence; D055815:Young Adult
keywords: Choroid; Glaucoma; Imaging