title: N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.
abstract: Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distinct from that of sulfonamide antibiotics, as para-aminobenzoic acid did not reduce efficacy. Chemical inhibitors play an important role in Chlamydia research as probes of potential targets and as drug development starting points.
authors.affiliation: Department of Chemistry, Umeå University, Umeå, Sweden.
authors.forename: Sania
authors.initials: S
authors.lastname: Marwaha
authors.forename: Hanna
authors.initials: H
authors.lastname: Uvell
authors.forename: Olli
authors.initials: O
authors.lastname: Salin
authors.forename: Anders E G
authors.initials: AE
authors.lastname: Lindgren
authors.forename: Jim
authors.initials: J
authors.lastname: Silver
authors.forename: Mikael
authors.initials: M
authors.lastname: Elofsson
authors.forename: Asa
authors.initials: A
authors.lastname: Gylfe
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002692:Chlamydia trachomatis / Q000187:drug effects*; D004353:Drug Evaluation, Preclinical; D013420:Sulfamethoxazole / Q000494:pharmacology*; D013444:Sulfisoxazole / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D013444:Sulfisoxazole; D013420:Sulfamethoxazole