title: Investigation of the correlation between 100 gram oral glucose tolerance test results and maternal leptin levels during pregnancy.
abstract: OBJECTIVE
  To investigate the correlation between maternal leptin levels and 100 gram oral glucose test (OGTT) results as well as the correlation between leptin levels and the development of gestational diabetes mellitus (GDM) and glucose intolerance during pregnancy.
  
  
  METHODS
  104 subjects with gestational weeks ranging from 24 to 32 weeks who had increased 50 gr OGTT values (>140) were included in this study. After the screening test, 100 gr OGTT was administered to the subjects. Sixty cases were selected from these subjects; twenty patients with one abnormal test result were identified as "glucose intolerant" group (Group 1), 20 patients with two abnormal test values were diagnosed with GDM (Group 2) and 20 patients with normal test results constituted the control group. The serum leptin levels of the groups were measured with enzyme linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The serum leptin level was 8.4±5.1 ng/ml for group 1, 9.1±5.3 ng/ml for group 2 and 6.3±4.6 ng/ml for the control group. Although serum leptin levels for group 1 and 2 was observed to be higher than the control group, the result was not statistically significant (p>0.05). This result did not change after adjusting for body mass index (BMI).
  
  
  CONCLUSIONS
  There is no statistically significant difference between leptin levels among three groups.
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Womens Health Hospital, Ankara, Turkey.
authors.forename: Ozlem Baykara
authors.initials: OB
authors.lastname: Sengül
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Tamer
authors.initials: T
authors.lastname: Mungan
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey.
authors.forename: Evrim
authors.initials: E
authors.lastname: Erdemoğlu
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Womens Health Hospital, Ankara, Turkey.
authors.forename: Göksel
authors.initials: G
authors.lastname: Islamoğlu
authors.affiliation: Department of Obstetrics and Gynecology, Zekai Tahir Burak Womens Health Hospital, Ankara, Turkey.
authors.forename: Nuran
authors.initials: N
authors.lastname: Kıyak
keywords: Gestational Diabetes Mellitus; Leptin; Oral Glucose Tolerance Test