title: Improvement of language functions in a chronic non-fluent post-stroke aphasic patient following bilateral sequential theta burst magnetic stimulation.
abstract: In chronic non-fluent aphasia patients, inhibition of the intact right hemisphere (RH), by transcranial magnetic stimulation (TMS) or similar methods, can induce improvement in language functions. The supposed mechanism behind this improvement is a release of preserved left hemisphere (LH) language networks from RH transcallosal inhibition. Direct stimulation of the damaged LH can sometimes bring similar results too. Therefore, we developed a novel treatment approach that combined direct LH (Broca's area (BA)) stimulation, by intermittent theta burst stimulation (TBS), with homologue RH area's inhibition, by continuous TBS. We present the results of application of 15 daily sessions of the described treatment approach in a right-handed patient with chronic post-stroke non-fluent aphasia. The intervention appeared to improve several language functions, but most notably propositional speech, semantic fluency, short-term verbal memory, and verbal learning. Bilateral TBS modulation of activation of the language-related areas of both hemispheres seems to be a feasible and promising way to induce recovery in chronic aphasic patients. Due to potentially cumulative physiological effects of bilateral stimulation, the improvements may be even greater than following unilateral interventions.
authors.affiliation: a Department of Neurophysiology , Institute for Medical Research, University of Belgrade , Beograd , Serbia.
authors.forename: Jasmina
authors.initials: J
authors.lastname: Vuksanović
authors.forename: Milan B
authors.initials: MB
authors.lastname: Jelić
authors.forename: Sladjan D
authors.initials: SD
authors.lastname: Milanović
authors.forename: Katarina
authors.initials: K
authors.lastname: Kačar
authors.forename: Ljubica
authors.initials: L
authors.lastname: Konstantinović
authors.forename: Saša R
authors.initials: SR
authors.lastname: Filipović
mesh_terms: D001037:Aphasia / Q000209:etiology / Q000628:therapy*; D065711:Broca Area / Q000503:physiopathology*; D002908:Chronic Disease; D006801:Humans; D007802:Language; D055909:Magnetic Field Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020127:Recovery of Function; D020521:Stroke / Q000150:complications*; D014706:Verbal Learning / Q000502:physiology
keywords: aphasia; interhemispheric interaction; language; propositional speech; rehabilitation; semantic fluency; stroke; transcranial magnetic stimulation; verbal learning