title: Biological properties of a DHA-containing structured phospholipid (AceDoPC) to target the brain.
abstract: 1-acetyl,2-docosahexaenoyl-glycerophosphocholine (AceDoPC) has been made to prevent docosahexaenoyl (DHA) to move to the sn-1 position as it rapidly does when present in 1-lyso,2-docosahexaenoyl-GPC (lysoPC-DHA), an efficient DHA transporter to the brain. When incubated with human blood, AceDoPC behaves closer to lysoPC-DHA than PC-DHA in terms of binding to plasma albumin and lipoproteins, and DHA incorporation into platelets and red cells. In addition, AceDoPC prevents more efficiently the deleterious effects of the experimental stroke in rats than does unesterified DHA. Also, AceDoPC inhibits platelet-activating factor-induced human blood platelet aggregation. Overall, AceDoPC might act as an efficient DHA transporter to the brain, and as a neuro-protective agent by itself.
authors.affiliation: Université de Lyon, Inserm UMR 1060 (CarMeN), IMBL/INSA-Lyon, Villeurbanne, France. Electronic address: michel.lagarde@insa-lyon.fr.
authors.forename: M
authors.initials: M
authors.lastname: Lagarde
authors.affiliation: Université de Lyon, Inserm UMR 1060 (CarMeN), IMBL/INSA-Lyon, Villeurbanne, France.
authors.forename: M
authors.initials: M
authors.lastname: Hachem
authors.affiliation: Université de Lyon, Inserm UMR 1060 (CarMeN), IMBL/INSA-Lyon, Villeurbanne, France.
authors.forename: N
authors.initials: N
authors.lastname: Bernoud-Hubac
authors.affiliation: Université de Lyon, Inserm UMR 1060 (CarMeN), IMBL/INSA-Lyon, Villeurbanne, France.
authors.forename: M
authors.initials: M
authors.lastname: Picq
authors.affiliation: Université de Lyon, Inserm UMR 1060 (CarMeN), IMBL/INSA-Lyon, Villeurbanne, France.
authors.forename: E
authors.initials: E
authors.lastname: Véricel
authors.affiliation: Université de Lyon, Inserm UMR 1060 (CarMeN), IMBL/INSA-Lyon, Villeurbanne, France.
authors.forename: M
authors.initials: M
authors.lastname: Guichardant
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D010713:Phosphatidylcholines / Q000494:pharmacology / Q000627:therapeutic use*; D010743:Phospholipids / Q000378:metabolism*; D020521:Stroke / Q000188:drug therapy
chemical_list: C000603131:1-acetyl-2-docosahexaenoyl-glycerophosphocholine; D018696:Neuroprotective Agents; D010713:Phosphatidylcholines; D010743:Phospholipids
keywords: Blood–brain barrier; Metabolism; Stroke