title: Pharmacologically, are smokers the same as non-smokers?
abstract: Growing evidence suggests that there are subpopulations of daily smokers ranging from light infrequent users to heavy daily users. In the present review we will investigate whether these differences can be explained by factors such as social context, responsiveness to environmental cues, personality traits, neurochemical and pharmacogenetic differences. We will also assess how controlled abstinence and free choice smoking paradigms in a human laboratory setting may help identify and characterize these differences and what can be learned from these models to accurately predict clinical efficacy in the later phase testing of new chemical entities for the treatment of smoking dependence.
authors.affiliation: Global Exploratory Development, New Medicine, UCB Pharma, Chemin du Foriest, Braine-l'Alleud 1420, Belgium. Electronic address: massimo.bani@ucb.com.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bani
authors.affiliation: Research and Development, Chief Medical Office, GSK, 5 Moore Drive, PO Box 13398, RTP, NC 27709-3398, USA.
authors.forename: Anne
authors.initials: A
authors.lastname: Andorn
authors.affiliation: Global Research & Development, Reckitt Benckiser Pharmaceuticals Inc., 10710 Midlothian Turnpike Suite 430, Richmond, VA 23235, USA.
authors.forename: Christian
authors.initials: C
authors.lastname: Heidbreder
mesh_terms: D000818:Animals; D006801:Humans; D008962:Models, Theoretical; D010551:Personality; D010597:Pharmacogenetics; D012907:Smoking / Q000453:epidemiology* / Q000523:psychology; D012931:Social Environment; D014029:Tobacco Use Disorder / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology*