title: Adenovirus-based vaccines for fighting infectious diseases and cancer: progress in the field.
abstract: The field of adenovirology is undergoing rapid change in response to increasing appreciation of the potential advantages of adenoviruses as the basis for new vaccines and as vectors for gene and cancer therapy. Substantial knowledge and understanding of adenoviruses at a molecular level has made their manipulation for use as vaccines and therapeutics relatively straightforward in comparison with other viral vectors. In this review we summarize the structure and life cycle of the adenovirus and focus on the use of adenovirus-based vectors in vaccines against infectious diseases and cancers. Strategies to overcome the problem of preexisting antiadenovirus immunity, which can hamper the immunogenicity of adenovirus-based vaccines, are discussed. When armed with tumor-associated antigens, replication-deficient and oncolytic adenoviruses can efficiently activate an antitumor immune response. We present concepts on how to use adenoviruses as therapeutic cancer vaccines and consider some of the strategies used to further improve antitumor immune responses. Studies that explore the prospect of adenoviruses as vaccines against infectious diseases and cancer are underway, and here we give an overview of the latest developments.
authors.affiliation: 1 Crucell Holland BV , 2333 CN Leiden, The Netherlands .
authors.forename: Dragomira
authors.initials: D
authors.lastname: Majhen
authors.forename: Hugo
authors.initials: H
authors.lastname: Calderon
authors.forename: Naresh
authors.initials: N
authors.lastname: Chandra
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Fajardo
authors.forename: Anandi
authors.initials: A
authors.lastname: Rajan
authors.forename: Ramon
authors.initials: R
authors.lastname: Alemany
authors.forename: Jerome
authors.initials: J
authors.lastname: Custers
mesh_terms: D056704:Adaptive Immunity; D000256:Adenoviridae / Q000276:immunology* / Q000502:physiology; D000818:Animals; D019496:Cancer Vaccines; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000276:immunology*; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology*
chemical_list: D019496:Cancer Vaccines; D014614:Vaccines, Synthetic