title: [Effects of nano-selenium on cognition performance of mice exposed in 1800 MHz radiofrequency fields].
abstract: OBJECTIVE
  To study the effects of nano-selenium (NSe) on cognition performance of mice exposed to 1800 MHz radiofrequency fields (RF).
  
  
  METHODS
  Male mice were randomly divided into four groups, control and nano-Se low, middle and high dose groups (L, M, H). Each group was sub-divided into three groups, RF 0 min, RF 30 min and RF 120 min. Nano-se solution (2, 4 and 8 microg/ml) were administered to mice of L, M, H groups by intra-gastric injection respectively, 0.5 ml/d for 50 days, the conctral group were administered with distilled water. At the 21st day, the mice in RF subgroup were exposed to 208 microW/cm2 1800 MHz radiofrequency fields (0, 30 and 120 min/d respectively) for 30 days. The cognitive ability of the mice were tested with Y-maze. Further, the levels of MDA, GABA, Glu, Ach and the activities of CAT and GSH-Px in cerebra were measured.
  
  
  RESULTS
  Significant impairments in learning and memory (P < 0.05) were observed in the RF 120 min group, and with reduction of the Ach level and the activities of CAT and GSH-Px and increase of the content of GABA, Glu and MDA in cerebrum. NSe enhanced cognitive performance of RF mice, decreased GABA, Glu and MDA levels, increased Ach levels, GSH-Px and CAT activities.
  
  
  CONCLUSIONS
  NSe could improve cognitive impairments of mice exposed to RF, the mechanism of which might involve the increasing antioxidation, decreasing free radical content and the changes of cerebra neurotransmitters.
authors.affiliation: Department of Chemistry, Biology and Materials Engineering, Suzhou Science and Technology University, Suzhou 215009, China. qinfenju@mail.usts.edu.cn
authors.forename: Fenju
authors.initials: F
authors.lastname: Qin
authors.affiliation: Department of Chemistry, Biology and Materials Engineering, Suzhou Science and Technology University, Suzhou 215009, China.
authors.forename: Hongxia
authors.initials: H
authors.lastname: Yuan
authors.affiliation: Department of Chemistry, Biology and Materials Engineering, Suzhou Science and Technology University, Suzhou 215009, China.
authors.forename: Jihua
authors.initials: J
authors.lastname: Nie
authors.affiliation: Department of Chemistry, Biology and Materials Engineering, Suzhou Science and Technology University, Suzhou 215009, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cao
authors.affiliation: Department of Chemistry, Biology and Materials Engineering, Suzhou Science and Technology University, Suzhou 215009, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Tong
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D003071:Cognition / Q000502:physiology / Q000528:radiation effects*; D003072:Cognition Disorders / Q000517:prevention & control*; D004574:Electromagnetic Fields / Q000009:adverse effects*; D004781:Environmental Exposure / Q000032:analysis*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000528:radiation effects; D053768:Metal Nanoparticles; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology; D011846:Radio Waves; D012643:Selenium / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D018377:Neurotransmitter Agents; D020011:Protective Agents; D012643:Selenium