title: No association of four candidate genetic variants in MnSOD and SYNIII with Parkinson's disease in two Chinese populations.
abstract: BACKGROUND
  The manganese superoxide dismutase (MnSOD) gene, which encodes a chief reactive oxygen species (ROS) scavenging enzyme, has been reported to be associated with the risk of developing sporadic Parkinson's disease (PD) in some Asian races and the synapsin III (SYN3) gene with some neuropsychiatric diseases.
  
  
  OBJECTIVE
  To explore the associations between the MnSOD and SYN III variations and PD in two Chinese populations from mainland China and Singapore.
  
  
  METHODS
  We recruited 2342 subjects including 1200 sporadic PD patients and 1142 healthy controls from two independent Asian countries. Using a case-control methodology, we genotyped the single nucleotide polymorphisms (SNP) in MnSOD (rs4880) and SYN III (rs3788470, rs3827336, rs5998557) to explore the associations with risk of PD.
  
  
  RESULTS
  The results showed the genotype distributions and minor allele frequencies (MAF) of MnSOD (rs4880) and SYN III (rs3788470, rs3827336, rs5998557) were not significantly different between PD patients and healthy controls in mainland China and Singapore, as well as in merged populations.
  
  
  CONCLUSIONS
  The variations of MnSOD (rs4880) and SYN III (rs3788470, rs3827336, rs5998557) were not major risk factors for PD among Chinese, at least in our study populations.
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China.
authors.forename: Wen Juan
authors.initials: WJ
authors.lastname: Yu
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China.
authors.forename: Nan Nan
authors.initials: NN
authors.lastname: Li
authors.affiliation: Duke-NUS Graduate Medical School, Singapore, Singapore ; Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore, Singapore.
authors.forename: Eng King
authors.initials: EK
authors.lastname: Tan
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China.
authors.forename: Lan
authors.initials: L
authors.lastname: Cheng
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China ; Department of Internal Medicine, Wangjiang Hospital, Sichuan University, Chengdu, Sichuan Province, PR China.
authors.forename: Jin Hong
authors.initials: JH
authors.lastname: Zhang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China.
authors.forename: Xue Ye
authors.initials: XY
authors.lastname: Mao
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China.
authors.forename: Xue Li
authors.initials: XL
authors.lastname: Chang
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China.
authors.forename: Dong Mei
authors.initials: DM
authors.lastname: Zhao
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China.
authors.forename: Qiao
authors.initials: Q
authors.lastname: Liao
authors.affiliation: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, PR China.
authors.forename: Rong
authors.initials: R
authors.lastname: Peng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics*; D051843:Synucleins / Q000235:genetics*
chemical_list: D051843:Synucleins; D013482:Superoxide Dismutase