title: Combination of diabetes risk factors and hepatic steatosis in Chinese: the Cardiometabolic Risk in Chinese (CRC) Study.
abstract: OBJECTIVE
  Hepatic steatosis has been related to insulin resistance and increased diabetes risk. We assessed whether combination of diabetes risk factors, evaluated by the Finnish Diabetes Risk Score, was associated with risk of hepatic steatosis in an apparently healthy Chinese population.
  
  
  METHODS
  The study samples were from a community-based health examination survey in central China. In total 1,780 men and women (18-64 y) were included in the final analyses. Hepatic steatosis was diagnosed by ultrasonography. We created combination of diabetes risk factors score on basis of age, Body Mass Index, waist circumference, physical activity at least 4 h a week, daily consumption of fruits, berries or vegetables, history of antihypertensive drug treatment, history of high blood glucose. The total risk score is a simple sum of the individual weights, and values range from 0 to 20.
  
  
  RESULTS
  Hepatic steatosis was present 18% in the total population. In multivariate models, the odds ratios of hepatic steatosis were 1.20 (95%CI 1.15-1.25) in men and 1.25 (95%CI 1.14-1.37) in women by each unit increase in the combination of diabetes risk factors score, after adjustment for blood pressure, liver enzymes, plasma lipids, and fasting glucose. The area under the receiver operating characteristic curve for hepatic steatosis was 0.78 (95%CI 0.76-0.80), 0.76 in men (95%CI 0.74-0.78) and 0.83 (95%CI 0.79-0.87) in women.
  
  
  CONCLUSIONS
  Our data suggest that combination of major diabetes risk factors was significantly related to risk of hepatic steatosis in Chinese adults.
authors.affiliation: Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Li
authors.affiliation: Department of Endocrinology, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical College, Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China.
authors.forename: Xuekui
authors.initials: X
authors.lastname: Liu
authors.affiliation: Xuzhou Medical College, Xuzhou, Jiangsu, China.
authors.forename: Qinqin
authors.initials: Q
authors.lastname: Qiu
authors.affiliation: Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D048909:Diabetes Complications / Q000453:epidemiology*; D005234:Fatty Liver / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012307:Risk Factors