title: Neisseria meningitidis serogroup W, Burkina Faso, 2012.
abstract: In 2010, Burkina Faso became the first country to introduce meningococcal serogroup A conjugate vaccine (PsA-TT). During 2012, Burkina Faso reported increases in Neisseria meningitidis serogroup W, raising questions about whether these cases were a natural increase in disease or resulted from serogroup replacement after PsA-TT introduction. We analyzed national surveillance data to describe the epidemiology of serogroup W and genotyped 61 serogroup W isolates. In 2012, a total of 5,807 meningitis cases were reported through enhanced surveillance, of which 2,353 (41%) were laboratory confirmed. The predominant organism identified was N. meningitidis serogroup W (62%), and all serogroup W isolates characterized belonged to clonal complex 11. Although additional years of data are needed before we can understand the epidemiology of serogroup W after PsA-TT introduction, these data suggest that serogroup W will remain a major cause of sporadic disease and has epidemic potential, underscoring the need to maintain high-quality case-based meningitis surveillance after PsA-TT introduction.
authors.forename: Jessica R
authors.initials: JR
authors.lastname: MacNeil
authors.forename: Isaïe
authors.initials: I
authors.lastname: Medah
authors.forename: Daouda
authors.initials: D
authors.lastname: Koussoubé
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Novak
authors.forename: Amanda C
authors.initials: AC
authors.lastname: Cohn
authors.forename: Fabien V K
authors.initials: FV
authors.lastname: Diomandé
authors.forename: Denis
authors.initials: D
authors.lastname: Yelbeogo
authors.forename: Jean Ludovic
authors.initials: JL
authors.lastname: Kambou
authors.forename: Tiga F
authors.initials: TF
authors.lastname: Tarbangdo
authors.forename: Rasmata
authors.initials: R
authors.lastname: Ouédraogo-Traoré
authors.forename: Lassana
authors.initials: L
authors.lastname: Sangaré
authors.forename: Cynthia
authors.initials: C
authors.lastname: Hatcher
authors.forename: Jeni
authors.initials: J
authors.lastname: Vuong
authors.forename: Leonard W
authors.initials: LW
authors.lastname: Mayer
authors.forename: Mamoudou H
authors.initials: MH
authors.lastname: Djingarey
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Clark
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Messonnier
mesh_terms: D000293:Adolescent; D002050:Burkina Faso / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005838:Genotype; D049674:History, 21st Century; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008585:Meningitis, Meningococcal / Q000453:epidemiology* / Q000266:history; D009345:Neisseria meningitidis / Q000145:classification* / Q000235:genetics; D011159:Population Surveillance; D065288:Serogroup; D055815:Young Adult
keywords: Burkina Faso; bacteria; children; meningococcal meningitis; serogroup A meningococcal conjugate vaccine; serogroup W meningococcal meningitis