title: Relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain: a literature review.
abstract: The aim of the current review was to investigate the relationship between levels of neuropeptide Substance P in periodontal disease and chronic pain. Substance P is a neuropeptide that is directly related with pain. In periodontal disease, it is expressed during the inflammatory process, and is one of the factors responsible for bone resorption. Studies have shown that Substance P levels are highest in the gingival crevicular fluid from sites with active periodontal disease and bone loss. The persistence of these substances could be sufficient to stimulate neurogenic inflammation in susceptible tissues, and cause pain. The scientific literature shows that Substance P expressed during periodontal disease can be a risk factor for patients with systemic inflammatory pathologies, such as chronic arthritis or rheumatoid arthritis. Additional research is needed to confirm the participation of this substance in the origin of some types of chronic pain.
authors.affiliation: Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, University of Estadual Paulista - UNESP, Araraquara, Sao Paulo, Brazil.
authors.forename: Erica Dorigatti
authors.initials: ED
authors.lastname: de Avila
authors.forename: Rafael Scaf
authors.initials: RS
authors.lastname: de Molon
authors.forename: Daniela Aparecida
authors.initials: DA
authors.lastname: de Godoi Gonçalves
authors.forename: Cinara Maria
authors.initials: CM
authors.lastname: Camparis
mesh_terms: D016301:Alveolar Bone Loss / Q000378:metabolism; D059350:Chronic Pain / Q000378:metabolism*; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D006801:Humans; D020078:Neurogenic Inflammation / Q000209:etiology / Q000378:metabolism; D010518:Periodontitis / Q000209:etiology / Q000378:metabolism*; D013373:Substance P / Q000032:analysis*
chemical_list: D013373:Substance P
keywords: Substance P; chronic pain; neurogenic inflammation; periodontal disease; pro-inflammatory neuropeptide