title: In vivo and in vitro evidence of somatostatin receptors expression in a dedifferentiated retroperitoneal liposarcoma.
abstract: A 62-year-old patient presented with mildly elevated catecholamines and an abdominal painless mass. Abdominal CT revealed an 18 × 12 cm tumor in the right retroperitoneum with intense contrast enhancement. Somatostatin receptor scintigraphy (SRS) showed pathologic uptake by the lesion. Given the suspicion of paraganglioma, the patient was referred to surgery for tumor removal. Surprisingly, the histopathological examination revealed a dedifferentiated liposarcoma. Somatostatin receptors of type 2 were identified and quantified by reverse transcription polymerase chain reaction. The unexpected presentation of our patient draws clinicians' attention when performing diagnostic procedure for retroperitoneal lesions, even though hormone secretion and positive SRS strongly suggest paraganglioma.
authors.affiliation: From the *Department of Biophysics and Nuclear Medicine, Strasbourg University Hospitals, Strasbourg; †ICube, University of Strasbourg/CNRS (UMR 7357) and Fédération de Médecine Translationnelle de Strasbourg, Faculty of Medicine, Strasbourg; ‡Departments of Pathology and §General Surgery, Strasbourg University Hospitals, Strasbourg; ¶Molecular Biology Laboratory, Conception University Hospital, Marseille; and ∥Department of Internal Medicine, Strasbourg University Hospitals, Strasbourg, France.
authors.forename: Alessio
authors.initials: A
authors.lastname: Imperiale
authors.forename: Marie-Pierre
authors.initials: MP
authors.lastname: Chenard
authors.forename: Serge
authors.initials: S
authors.lastname: Rohr
authors.forename: Anne
authors.initials: A
authors.lastname: Barlier
authors.forename: Bernard
authors.initials: B
authors.lastname: Goichot
mesh_terms: D006801:Humans; D033162:Incidental Findings; D008080:Liposarcoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010235:Paraganglioma / Q000000981:diagnostic imaging* / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000235:genetics / Q000378:metabolism*; D012186:Retroperitoneal Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D017481:Receptors, Somatostatin; C093733:somatostatin receptor 2