title: Association between polymorphisms in OAS2 and CD209 genes and predisposition to chronic hepatitis C in Russian population.
abstract: Chronic hepatitis C is a severe liver disease caused by positive-strand RNA virus. Previously, we reported an association between seven single nucleotide polymorphisms (SNPs) in four innate immunity genes (OAS2, OAS3, CD209, and TLR3) and human predisposition to tick-borne encephalitis, caused by a virus from the same Flaviviridae family, in a Russian population. Currently, genotype and allele frequencies for these SNPs were analyzed in 75 chronic hepatitis C patients and compared with the population control (269 Novosibirsk citizens). Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population.
authors.affiliation: Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, 10 Lavrentyeva Ave., Novosibirsk 630090, Russia. Electronic address: barkhash@bionet.nsc.ru.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Barkhash
authors.affiliation: Laboratory of Viral Hepatitis, State Research Center of Virology and Biotechnology "Vector", Koltsovo, Novosibirsk Region(1) 630559, Russia.
authors.forename: Galina V
authors.initials: GV
authors.lastname: Kochneva
authors.affiliation: Laboratory of Viral Hepatitis, State Research Center of Virology and Biotechnology "Vector", Koltsovo, Novosibirsk Region(1) 630559, Russia.
authors.forename: Elena V
authors.initials: EV
authors.lastname: Chub
authors.affiliation: Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, 10 Lavrentyeva Ave., Novosibirsk 630090, Russia.
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Mikhailova
authors.affiliation: Laboratory of Human Molecular Genetics, Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Branch, 10 Lavrentyeva Ave., Novosibirsk 630090, Russia.
authors.forename: Aida G
authors.initials: AG
authors.lastname: Romaschenko
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D015815:Cell Adhesion Molecules / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000453:epidemiology*; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics*; D012426:Russia; D055815:Young Adult; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015088:2',5'-Oligoadenylate Synthetase; D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
keywords: Chronic hepatitis C; Genetic predisposition to disease; Single nucleotide polymorphism