title: [Relationship between effect of lamivudine in the treatment of cirrhotic patients with uncompensated hepatitis B with HBV genotypes and cytotoxic T lymphocyte].
abstract: OBJECTIVE
  To explore relationship between effect of Lamivudine in the treatment of cirrhotic patients with uncompensated hepatitis B with hepatitis B virus (HBV)genotypes and HBV specific cytotoxic T lymphocytes (CTL).
  
  
  METHODS
  80 cases of uncompensated cirrhotic hepatitis B (40 cases with genotype B and 40 with genotype C), HBV DNA positive, HBeAg positive and human leukocyte antigen (HLA)-A2 positive,were treated with Lamivudine 100 mg/d, one year later, its effect and relationship with HBV genotypes and HBV specific CTL were observed.
  
  
  RESULTS
  HBV DNA turned negative:40 cases with genotype B turned negative (100%). In the 9th and 10th month of treatment, there was one case with genotype C had YMDD variation respectively and Adefovir dipivoxil was used for treatment, of the rest 38 cases, HBV DNA of 26 cases (68.42%) turned negative,HBV DNA negative rate of patients with genotype is lower than that of patients with genotype B, chi2 = 14.91, P < 0.01. HBeAg turned negative: 18 cases with genotype B (45%) turned negative, more than that of patients with genotype C (7 cases, 18.42%), chi2 = 6.32, P < 0.05. Peripheral blood HBV specific CTL level: before treatment, it was (0.33 +/- 0.03)% of patients with genotype B,higher than that of patients with genotype C [(0.11 +/- 0.02)%], t = 8.12, P < 0.001. 1 year after treatment: it was (0.44 +/- 0.04)% of patients with genotype B, higher than that before treatment, t = 4.01, P < 0.001, it was also higher than that of patients with genotype C 1 year after treatment [(0.23 +/- 0.03)%], t = 5.63, P < 0.01, alanine amino-transferase (ALT) returned to normal: 38 cases with genotype B (95%) returned to normal, more than that of patients with genotype C (28 cases, 73.68%), X2 = 6.79, P < 0.01.
  
  
  CONCLUSIONS
  Effect of Lamivudinein the treatment of cirrhotic patients with uncompensated hepatitis B is better in patients with genotype B than patients with genotype C, its mechanism may be related to lower level of HBV specific CTL in patients with genotype C than patients with genotype B.
authors.affiliation: Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.affiliation: Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
authors.forename: Xi-Bing
authors.initials: XB
authors.lastname: Gu
authors.affiliation: Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
authors.forename: Yin-Fang
authors.initials: YF
authors.lastname: Zhu
authors.affiliation: Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiao-Juan
authors.affiliation: Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
authors.forename: Xiang-Hu
authors.initials: XH
authors.lastname: Jiang
authors.affiliation: Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Huang
authors.affiliation: Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
authors.forename: Yuan-Wang
authors.initials: YW
authors.lastname: Qiu
authors.affiliation: Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
authors.forename: Hang-Yuan
authors.initials: HY
authors.lastname: Wu
authors.affiliation: Wuxi Hospital for Infectious Diseases, Wuxi 214005, China.
authors.forename: Ping
authors.initials: P
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000378:metabolism; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D005838:Genotype; D006509:Hepatitis B / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology* / Q000821:virology; D006515:Hepatitis B virus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000201:enzymology / Q000276:immunology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D000998:Antiviral Agents; D019259:Lamivudine; D000410:Alanine Transaminase