title: Dynamic survey of mitochondria by ubiquitin.
abstract: Ubiquitin is a post-translational modifier with proteolytic and non-proteolytic roles in many biological processes. At mitochondria, it performs regulatory homeostatic functions and contributes to mitochondrial quality control. Ubiquitin is essential for mitochondrial fusion, regulates mitochondria-ER contacts, and participates in maternal mtDNA inheritance. Under stress, mitochondrial dysfunction induces ubiquitin-dependent responses that involve mitochondrial proteome remodeling and culminate in organelle removal by mitophagy. In addition, many ubiquitin-dependent mechanisms have been shown to regulate innate immune responses and xenophagy. Here, we review the emerging roles of ubiquitin at mitochondria.
authors.affiliation: Institute for Genetics Centre for Molecular Medicine (CMMC) Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD) University of Cologne, Cologne, Germany.
authors.forename: Mafalda
authors.initials: M
authors.lastname: Escobar-Henriques
authors.forename: Thomas
authors.initials: T
authors.lastname: Langer
mesh_terms: D000818:Animals; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism; D063269:Mitochondrial Turnover; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism*
chemical_list: D024101:Mitochondrial Proteins; D025801:Ubiquitin