title: β-catenin-mediated inhibition of cross-priming: A new mechanism for tumors to evade immunosurveillance.
abstract: Cross-priming plays a major role in generating CD8+T cell-dependent antitumor immunity through cross-presentation. However, the cross-presentation of tumor-associated antigens by dendritic cells often promotes tolerance rather than CD8+T-cell immunity. We have now identified a β-catenin-dependent pathway of cross-priming inhibition as a novel and potentially broad mechanism whereby neoplastic cells promote immunosuppression.
authors.affiliation: Department of Immunology; Roswell Park Cancer Institute; Buffalo, NY USA.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Fu
authors.affiliation: Department of Immunology; Roswell Park Cancer Institute; Buffalo, NY USA.
authors.forename: Aimin
authors.initials: A
authors.lastname: Jiang
keywords: DC-based vaccine; antitumor CD8+ immunity; cross-priming; immunosuppression