title: Development and in vitro characterization of mebendazole delayed release tablet for colonic drug delivery.
abstract: The main objective behind this study was to formulate delayed release colon targeted tablet of Mebendazole by using different polymers. The precompressional parameters of powder blend were studied. The wet granulation method was used for the preparation of tablets. The tablets of all formulation were subjected for different physicochemical evaluation. The drug-excipient interaction study was carried out by using Fourier transforms Infrared spectroscopy (FTIR). The in vitro evaluation was carried out at different pH ranges (0.1M HCl, 6.8 and 7.4 Phosphate buffer) for the prepared tablets. From the stability, Fourier transform infra-red spectroscopy studies Mebendazole tablet does not show any interaction between drug and polymer. The prepared tablets were complied all the physicochemical test as per official limit. The formulated (M3) batch shows better sustained release 99.89% over a period of 12 hours and the data was fitted into Korsemeyer-Peppas kinetic equation. The result indicates that Mebendazole colon targeted matrix tablet remain stable in the stomach and shows better release into the colon with the help of pH dependent synthetic polymers.
authors.affiliation: Institute of Pharmaceutical Education, Boradi, Tal-Shirpur, Dist-Dhule, MS, India.
authors.forename: Dheeraj
authors.initials: D
authors.lastname: Baviskar
authors.affiliation: Institute of Pharmaceutical Education, Boradi, Tal-Shirpur, Dist-Dhule, MS, India.
authors.forename: Amarjit
authors.initials: A
authors.lastname: Rajput
authors.affiliation: Institute of Pharmaceutical Education, Boradi, Tal-Shirpur, Dist-Dhule, MS, India.
authors.forename: Kapil
authors.initials: K
authors.lastname: Bare
authors.affiliation: Institute of Pharmaceutical Education, Boradi, Tal-Shirpur, Dist-Dhule, MS, India.
authors.forename: Yogeshkumar
authors.initials: Y
authors.lastname: Biranwar
authors.affiliation: Institute of Pharmaceutical Education, Boradi, Tal-Shirpur, Dist-Dhule, MS, India.
authors.forename: Hiralal
authors.initials: H
authors.lastname: Chaudhari
authors.affiliation: Institute of Pharmaceutical Education, Boradi, Tal-Shirpur, Dist-Dhule, MS, India.
authors.forename: Deepak
authors.initials: D
authors.lastname: Narkhede
authors.affiliation: College of Pharmacy, I.P.S. Academy, Rajendra Nagar, Indore, MP, India.
authors.forename: Dinesh
authors.initials: D
authors.lastname: Jain
mesh_terms: D000465:Algorithms; D000969:Antinematodal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019540:Area Under Curve; D003106:Colon / Q000378:metabolism*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004355:Drug Stability; D005079:Excipients; D006207:Half-Life; D006245:Hardness Tests; D008463:Mebendazole / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D011208:Powders; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
chemical_list: D000969:Antinematodal Agents; D003692:Delayed-Action Preparations; D005079:Excipients; D011208:Powders; D013607:Tablets; D008463:Mebendazole