title: Efficacy and safety of potassium-titanyl- phosphate laser vaporization for clinically non-muscle invasive bladder cancer.
abstract: OBJECTIVE
  Although transurethral resection of the bladder tumor (TURBT) is still regarded as thegold standard for the treatment of clinical non-muscle invasive bladder cancer, alternative surgical options remain investigating. Our aim was to evaluate the efficacy and safety of potassium- titanyl-phosphate (KTP) laser for the treatment of primary, clinically non-muscle invasive bladder cancer compared with standard transurethral resection of bladder tumor.
  
  
  METHODS
  The data of primary non-muscle invasive bladder cancer patients treated by either KTP laser vaporization (PVB group) or TURBT were analyzed retrospectively. The preoperative conditions and intraoperative complications such as obturator nerve reflex and bladder perforation and postoperative characteristics such as catheterization time and tumor recurrence were compared.
  
  
  RESULTS
  The patients' demographics and tumor characteristics in the two groups were comparable. PVB was superior to TURBT in terms of intraoperative complications such as obturator nerve reflex (P = .0289), postoperative bladder irrigation (P = .038) and postoperative catheterization time (P < .0001). Recurrence rate after PVB was also lower than that after TURBT.
  
  
  CONCLUSIONS
  Our results indicated that PVB is a feasible, safe and effective alternative surgical approach for the management of primary, clinically non-muscle invasive bladder cancer, especially for those with lifetime oral taken anticoagulation medicine, with fewer perioperative complications and lower recurrence.
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou,215004,China. doc_ydr@hotmail.com.
authors.forename: Dongrong
authors.initials: D
authors.lastname: Yang
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou,215004,China.
authors.forename: Boxin
authors.initials: B
authors.lastname: Xue
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou,215004,China.
authors.forename: Yachen
authors.initials: Y
authors.lastname: Zang
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou,215004,China.
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou,215004,China.
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou,215004,China.
authors.forename: Yibin
authors.initials: Y
authors.lastname: Zhou
authors.affiliation: Department of Urology, the Second Affiliated Hospital of Soochow University, Suzhou,215004,China. shanyx1002@aliyun.com.
authors.forename: Yuxi
authors.initials: Y
authors.lastname: Shan
mesh_terms: D000328:Adult; D015653:Cystectomy / Q000379:methods*; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010710:Phosphates / Q000627:therapeutic use; D012189:Retrospective Studies; D014025:Titanium / Q000627:therapeutic use; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*
chemical_list: D010710:Phosphates; C064806:potassium titanylphosphate; D014025:Titanium