title: Gut hormone profiles in preterm and term infants during the first 2 months of life.
abstract: OBJECTIVE
  To investigate changes of gut hormones in term and preterm infants in the first 2 months after birth, as the role and relationships of gut hormones in premature infants has not been well elucidated.
  
  
  METHODS
  In 29 preterm and five term infants, fasting serum concentrations of leptin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), peptide YY (PYY), pancreatic polypeptide, insulin, amylin, and ghrelin were measured using a bead array system.
  
  
  RESULTS
  Serum leptin concentration soon after birth showed a positive correlation with gestational week in all infants (r=0.623, p<0.01). Serum leptin level rapidly decreased in all infants. In preterm infants, serum GLP-1 levels at birth showed negative correlations with gestational week (r=-0.447, p=0.02). Serum GIP, GLP-1, and PYY levels increased after birth and were persistently high until 10 weeks of life.
  
  
  CONCLUSIONS
  Serum concentrations of different gut hormones changed postnatally in their specific ways in preterm infants.
authors.forename: Ryou
authors.initials: R
authors.lastname: Kawamata
authors.forename: Yume
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yukari
authors.initials: Y
authors.lastname: Yada
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Koike
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kono
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yada
authors.forename: Naoto
authors.initials: N
authors.lastname: Takahashi
mesh_terms: D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D005768:Gastrointestinal Hormones / Q000097:blood*; D005865:Gestational Age; D054439:Ghrelin / Q000097:blood; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood*; D007328:Insulin / Q000097:blood; D058228:Islet Amyloid Polypeptide / Q000097:blood; D020738:Leptin / Q000097:blood*; D010191:Pancreatic Polypeptide / Q000097:blood; D019894:Peptide YY / Q000097:blood
chemical_list: D005768:Gastrointestinal Hormones; D054439:Ghrelin; D007328:Insulin; D058228:Islet Amyloid Polypeptide; D020738:Leptin; D019894:Peptide YY; D005749:Gastric Inhibitory Polypeptide; D010191:Pancreatic Polypeptide; D052216:Glucagon-Like Peptide 1