title: Redox biology: interface of the exposome with the proteome, epigenome and genome.
abstract: The exposome is the cumulative measure of environmental influences and associated biological responses throughout lifespan, including exposures from the environment, diet, behavior and endogenous processes. Much of the direct interaction of an individual's exposome involves redox biology as the body responds to environmental, dietary and behavioral risk factors of disease. The present commentary addresses this critical interface and the need for redox biologists to lead development of concepts and strategies to sequence the exposome.
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, 205 Whitehead Research Center, Atlanta, GA 30322, USA.
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Go
authors.affiliation: Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, 205 Whitehead Research Center, Atlanta, GA 30322, USA.
authors.forename: Dean P
authors.initials: DP
authors.lastname: Jones
mesh_terms: D004781:Environmental Exposure; D044127:Epigenesis, Genetic; D015870:Gene Expression / Q000187:drug effects; D015894:Genome, Human; D015438:Health Behavior; D006801:Humans; D008019:Life Style; D010084:Oxidation-Reduction; D020543:Proteome; D012307:Risk Factors
chemical_list: D020543:Proteome
keywords: Environmental exposures; Life cycle; Oxidative stress; Personalized medicine; Redox signaling