title: In vitro and in vivo studies of the biological activity of novel arylimidamides against Trypanosoma cruzi.
abstract: Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.
authors.affiliation: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: J S
authors.initials: JS
authors.lastname: De Araújo
authors.affiliation: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: C F
authors.initials: CF
authors.lastname: Da Silva
authors.affiliation: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: D G J
authors.initials: DG
authors.lastname: Batista
authors.affiliation: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: P B
authors.initials: PB
authors.lastname: Da Silva
authors.affiliation: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: M B
authors.initials: MB
authors.lastname: Meuser
authors.affiliation: Departamento de Genética e Biologia Molecular, Universidade do Estado do Rio de Janeiro, Instituto Biomédico, Departamento de Genética e Biologia Molecular, Laboratório de Genotoxicidade, Rio de Janeiro, Brazil.
authors.forename: C A F
authors.initials: CA
authors.lastname: Aiub
authors.affiliation: Departamento de Genética e Biologia Molecular, Universidade do Estado do Rio de Janeiro, Instituto Biomédico, Departamento de Genética e Biologia Molecular, Laboratório de Genotoxicidade, Rio de Janeiro, Brazil.
authors.forename: M F V
authors.initials: MF
authors.lastname: da Silva
authors.affiliation: Departamento de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: C F
authors.initials: CF
authors.lastname: Araújo-Lima
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
authors.forename: M
authors.initials: M
authors.lastname: Banerjee
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia, USA Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
authors.forename: A A
authors.initials: AA
authors.lastname: Farahat
authors.affiliation: Department of Chemistry and Physics, Georgia Regents University, Augusta, Georgia, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Stephens
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Boykin
authors.affiliation: Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil soeiro@ioc.fiocruz.br.
authors.forename: M N C
authors.initials: MN
authors.lastname: Soeiro
mesh_terms: D000578:Amidines / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy* / Q000401:mortality / Q000469:parasitology; D008297:Male; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy* / Q000401:mortality / Q000469:parasitology; D021261:Parasitic Sensitivity Tests; D014344:Trypanocidal Agents / Q000737:chemistry / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D000578:Amidines; D014344:Trypanocidal Agents