title: Data mining and bioinformatics of the expression data of esophageal squamous cell carcinoma.
abstract: The aim is to explore the molecular regulation mechanism of the pathogenesis of the esophageal squamous cell carcinoma. The expression data of esophageal squamous cell carcinoma were obtained from the GEO database. The differential expression genes were identified by the BRB-array tools and the pathway was analyzed by DAVID online tools. The class comparison analysis showed that there were 376 differential expression genes. These genes involved in many tumor-related pathways. What is more, these pathways had common genes. As a conclusion, it was helpful to comprehensively understand the pathogenesis of esophageal squamous carcinoma using data mining and bioinformatics analysis of esophageal squamous cell carcinoma. It would offer new ideas for target therapy of the esophageal squamous cell carcinoma.
authors.affiliation: Cancer Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
authors.forename: Yao
authors.initials: Y
authors.lastname: Sun
authors.forename: Xufeng
authors.initials: X
authors.lastname: Li
authors.forename: Chunyu
authors.initials: C
authors.lastname: Jiang
authors.forename: Mingxing
authors.initials: M
authors.lastname: Xiao
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jiren
authors.initials: J
authors.lastname: Zhang
authors.forename: Junguo
authors.initials: J
authors.lastname: Bu
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D019295:Computational Biology / Q000379:methods*; D057225:Data Mining / Q000379:methods*; D004938:Esophageal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D000077277:Esophageal Squamous Cell Carcinoma; D020869:Gene Expression Profiling; D006801:Humans; D015398:Signal Transduction / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53