title: Perinatal Treponema pallidum: evidence based guidelines to reduce mother to child transmission.
abstract: Universal antenatal screening for T. pallidum is standard in Irish maternity units. The prevalence of adult syphilis has increased in Ireland. We audited the neonatal management of infants exposed to T. pallidum in utero. A cross sectional retrospective analysis of all pregnancies with confirmed positive serology for T. pallidum from January 2005 to December 2010 was conducted at the National Maternity Hospital, Holles St. Data were analysed using SPSS 14.0. Ethical approval was obtained. There were 55,058 live births during the study period. Fifty-eight women had positive serology and 41 met inclusion criteria. Infant evaluation and follow up was decided by allocation to an evidence based algorithm. Twenty-one infants (51%) were accurately allocated and assessed, 5 (12%) had a partial assessment and the algorithm was incorrectly applied in 15 (36%) of cases. Failure to adhere to evidence based neonatal guidelines is common and undermines efficacy of the screening program.
authors.affiliation: National Maternity Hospital, Holles St, Dublin 2. bridgetfreyne@gmail.com
authors.forename: B
authors.initials: B
authors.lastname: Freyne
authors.affiliation: National Maternity Hospital, Holles St, Dublin 2.
authors.forename: A
authors.initials: A
authors.lastname: Stafford
authors.affiliation: National Maternity Hospital, Holles St, Dublin 2.
authors.forename: S
authors.initials: S
authors.lastname: Knowles
authors.affiliation: National Maternity Hospital, Holles St, Dublin 2.
authors.forename: A
authors.initials: A
authors.lastname: O'Hora
authors.affiliation: National Maternity Hospital, Holles St, Dublin 2.
authors.forename: E
authors.initials: E
authors.lastname: Molloy
mesh_terms: D000328:Adult; D000465:Algorithms; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D013587:Syphilis / Q000635:transmission*