title: Impairment of ghrelin synthesis in Helicobacter pylori-colonized stomach: new clues for the pathogenesis of H. pylori-related gastric inflammation.
abstract: Ghrelin, the ligand of growth hormone secretagogue receptor 1a, takes part in several functions of the digestive system, including regulation of appetite, energy homeostasis, gastric acid secretion and motility. Ghrelin has also immunoregulatory properties and is supposed to inhibit some inflammatory pathways that can mediate gastric damage. Interestingly, ghrelin synthesis is reduced in the gastric mucosa of patients with Helicobacter pylori (H. pylori) infection, a worldwide condition inducing a T helper (Th)1/Th17 cell response-driven gastritis, which may evolve towards gastric atrophy and cancer. In this article, we review the available data on the expression of ghrelin in H. pylori infection and discuss how the defective ghrelin synthesis may contribute to sustain the ongoing inflammatory response in this disease.
authors.affiliation: Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Omero Alessandro
authors.initials: OA
authors.lastname: Paoluzi
authors.affiliation: Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Del Vecchio Giovanna
authors.initials: del VG
authors.lastname: Blanco
authors.affiliation: Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Caruso
authors.affiliation: Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Ivan
authors.initials: I
authors.lastname: Monteleone
authors.affiliation: Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Monteleone
authors.affiliation: Omero Alessandro Paoluzi, Giovanna Del Vecchio Blanco, Roberta Caruso, Ivan Monteleone, Giovanni Monteleone, Francesco Pallone, Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pallone
mesh_terms: D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism*; D005756:Gastritis / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D054439:Ghrelin / Q000378:metabolism*; D016481:Helicobacter Infections / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology; D016480:Helicobacter pylori / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D015398:Signal Transduction; D013270:Stomach / Q000382:microbiology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000378:metabolism / Q000382:microbiology
chemical_list: D054439:Ghrelin; D018836:Inflammation Mediators
keywords: Gastritis; Ghrelin; Helicobacter pylori; T helper 1 cells