title: New markers: urine xanthine oxidase and myeloperoxidase in the early detection of urinary tract infection.
abstract: OBJECTIVE
  The aim of this study was to evaluate if xanthine oxidase and myeloperoxidase levels quantitation method may alternate routine culture method, which takes more time in the diagnosis of urinary tract infections.
  
  
  METHODS
  Five hundred and forty-nine outpatients who had admitted to Clinic Microbiology Laboratory were included in the study. The microorganisms were identified by using VITEK System. The urine specimens that were negative from the quantitative urine culture were used as controls. The activities of MPO and XO in spot urine were measured by spectrophotometric method.
  
  
  RESULTS
  Through the urine cultures, 167 bacteria were isolated from 163 urine specimens; 386 cultures yielded no bacterial growth. E. coli was the most frequent pathogen. In infection with E. coli both XO and MPO levels were increased the most. The sensitivity, specificity, positive predictive value, and negative predictive value for XO were 100%, 100%, 100%, and 100%, respectively. These values for MPO were 87%, 100%, 100%, and 94%, respectively.
  
  
  CONCLUSIONS
  These data obtained suggest that urine XO and MPO levels may be new markers in the early detection of UTI.
authors.affiliation: Yasamlab Laboratory, Department of Clinical Microbiology, Guzelevler Mahallesi Papatya Sokak Mobilyacılar Sitesi 6, Blok No. 13, Yuregir, 01220 Adana, Turkey.
authors.forename: Pınar
authors.initials: P
authors.lastname: Ciragil
authors.affiliation: Sutcu Imam University, Faculty of Medicine, Department of Biochemistry, 46050, Kahramanmaras, Turkey.
authors.forename: Ergul Belge
authors.initials: EB
authors.lastname: Kurutas
authors.affiliation: Cukurova University, Faculty of Medicine, Department of Microbiology, 01050, Adana, Turkey.
authors.forename: Meral
authors.identifier: 0000-0003-0418-1921
authors.initials: M
authors.lastname: Miraloglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000652:urine; D002648:Child; D002675:Child, Preschool; D042241:Early Diagnosis; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000201:enzymology / Q000652:urine*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000652:urine*; D011507:Proteinuria / Q000175:diagnosis / Q000201:enzymology / Q000382:microbiology / Q000652:urine*; D012680:Sensitivity and Specificity; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000201:enzymology / Q000652:urine*; D014969:Xanthine Oxidase / Q000652:urine*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D009195:Peroxidase; D014969:Xanthine Oxidase