title: Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: synthetic approaches and multifarious applications.
abstract: Drug development has been a principal driving force in the rapid maturation of the field of medicinal chemistry during the past several decades. During this period, the intriguing and challenging molecular architectures of nitrogen-containing heterocycles with potential bioactive properties have received significant attention from researchers engaged in the areas of natural product synthesis and heterocyclic methodology, and constituted a continuous stimulus for development in bio(organic) chemistry. In this perspective, the current review article is an effort to summarize recent developments in the environmentally benign synthetic methods providing access to quinazoline and quinazolinone scaffolds with promising biological potential. This article also aims to discuss potential future directions on the development of more potent and specific analogues for various biological targets.
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Imtiaz
authors.initials: I
authors.lastname: Khan
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Aliya
authors.initials: A
authors.lastname: Ibrar
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
authors.forename: Naeem
authors.initials: N
authors.lastname: Abbas
authors.affiliation: Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address: aamersaeed@yahoo.com.
authors.forename: Aamer
authors.initials: A
authors.lastname: Saeed
mesh_terms: D015394:Molecular Structure; D011799:Quinazolines / Q000737:chemistry*; D052999:Quinazolinones / Q000737:chemistry*
chemical_list: D011799:Quinazolines; D052999:Quinazolinones
keywords: Biological activities; Heterocycles; Inhibitors; Quinazolines; Quinazolinones; Synthetic methods