title: Susceptibility of Stenotrophomonas maltophilia clinical strains in China to antimicrobial combinations.
abstract: We aimed to investigate the activity levels of several combinations of antimicrobials against Stenotrophomonas maltophilia. In this study, the antimicrobial susceptibility of S. maltophilia clinical isolates was determined, and the synergistic activity of three pairs of antimicrobial combinations was evaluated by the fractional inhibitory concentration index (FICI). The antimicrobial susceptibility in vitro against 83 S. maltophilia strains was greater for minocycline (80·7%) than for trimethoprim-sulfamethoxazole (51·8%), and levofloxacin (50·6%). The rate of resistance was highest for ticarcillin-clavulanate and ceftazidime (63·8%) and resistance to trimethoprim-sulfamethoxazole (TMP-SMX) was 48·2%. All three combinations were tested against susceptible isolates. Two of the combinations, TMP-SMX+ceftazidime and levofloxacin+ceftazidime were more effective than the combination of TMP-SMX+levofloxacin. We recommend acquiring more clinical data in order to explore combination therapy, which is a promising treatment of S. maltophilia infections.
authors.forename: Li-Fen
authors.initials: LF
authors.lastname: Hu
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Gao
authors.forename: Ying
authors.initials: Y
authors.lastname: Ye
authors.forename: Xi
authors.initials: X
authors.lastname: Chen
authors.forename: Xiang-Tian
authors.initials: XT
authors.lastname: Zhou
authors.forename: Hai-Fei
authors.initials: HF
authors.lastname: Yang
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Liiu
authors.forename: Qing
authors.initials: Q
authors.lastname: Mei
authors.forename: Jia-Bin
authors.initials: JB
authors.lastname: Li
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002681:China; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D004359:Drug Therapy, Combination; D006801:Humans; D064704:Levofloxacin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology; D020615:Stenotrophomonas maltophilia / Q000187:drug effects* / Q000302:isolation & purification; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D064704:Levofloxacin; D014295:Trimethoprim; D008911:Minocycline; D013420:Sulfamethoxazole
keywords: Antimicrobial susceptibility,; Stenotrophomonas maltophilia,; combination testing,; synergy