title: Joseph Erlanger (1874-1965): the cardiovascular investigator who won a Nobel Prize in neurophysiology.
abstract: Born in San Francisco in 1874 into the family of German immigrants in which he was the only one to proceed beyond elementary education, Joseph Erlanger graduated from the University of California (Berkeley) in 1894. He was about to enter the local Cooper Medical School when he was told that the new medical school in Johns Hopkins University (Baltimore) aimed to surpass all others, and there he graduated and was later coached for a career in academic life by William H Howell (1860-1945). In due course he held the Chairs of Physiology in the University of Wisconsin (Madison) and Washington University at St Louis, Missouri. He showed that the Bundle of His is indeed the functional link between the atria and the ventricles in the mammalian heart and that the Korotkoff sounds are produced by a 'breaker' phenomenon resulting from instability of the pulse wave in a partially occluded artery. With Herbert S Gasser (1888-1963) he was awarded the Nobel Prize in 1944 for their work on action currents in peripheral nerve fibres. The history of science occupied him during his retirement. He died at St Louis in 1965.
authors.affiliation: UCD School of Medicine and Medical Science, Health Sciences Centre, Belfield, Dublin 4, Ireland caoimhghin.breathnac@ucd.ie.
authors.forename: Caoimhghín S
authors.initials: CS
authors.lastname: Breathnach
authors.affiliation: UCD School of Medicine and Medical Science, Health Sciences Centre, Belfield, Dublin 4, Ireland.
authors.forename: John B
authors.initials: JB
authors.lastname: Moynihan
mesh_terms: D002309:Cardiology / Q000266:history*; D049672:History, 19th Century; D049673:History, 20th Century; D009482:Neurophysiology / Q000266:history*; D014481:United States
keywords: Bundle of His; Korotkoff sounds; compund action potential