title: Meta-analysis of sonication fluid samples from prosthetic components for diagnosis of infection after total joint arthroplasty.
abstract: This meta-analysis included 12 studies that evaluated sonication fluid cultures (SFC) for the diagnosis of prosthetic joint infection (PJI). The pooled sensitivity and specificity were 0.80 (95% confidence interval [CI], 0.74 to 0.84) and 0.95 (CI, 0.90 to 0.98), respectively. Subgroup analyses showed that a 14-day anaerobic culture may improve sensitivity, the use of centrifugation or vortexing may improve specificity, and the use of 400 to 500 ml of Ringer's solution for containers may improve sensitivity and specificity. The best SFC cutoff was ≥5 CFU. In conclusion, SFC has high sensitivity and very high specificity for diagnosing PJI.
authors.affiliation: Department of Orthopedics, Shanghai Key Laboratory of Orthopedic Implants, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Zanjing
authors.initials: Z
authors.lastname: Zhai
authors.forename: Haowei
authors.initials: H
authors.lastname: Li
authors.forename: An
authors.initials: A
authors.lastname: Qin
authors.forename: Guangwang
authors.initials: G
authors.lastname: Liu
authors.forename: Xuqiang
authors.initials: X
authors.lastname: Liu
authors.forename: Chuanlong
authors.initials: C
authors.lastname: Wu
authors.forename: Huiwu
authors.initials: H
authors.lastname: Li
authors.forename: Zhenan
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xinhua
authors.initials: X
authors.lastname: Qu
authors.forename: Kerong
authors.initials: K
authors.lastname: Dai
mesh_terms: D000368:Aged; D001178:Arthroplasty / Q000379:methods; D006801:Humans; D008875:Middle Aged; D019736:Prostheses and Implants / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000175:diagnosis* / Q000382:microbiology*; D012680:Sensitivity and Specificity; D013010:Sonication / Q000379:methods