title: Is mifepristone 100mg an effective alternative to standard dose for medical abortion.
abstract: OBJECTIVE
  To study the efficacy of a low dose of mifepristone (100 mg) in combination with misoprostol, in women undergoing medical termination of pregnancy up to gestation of 49 days.
  
  
  METHODS
  A prospective study was performed in 50 women (mean age 26.54±3.68 years) with single intrauterine pregnancy of up to 49 days of gestation, presenting to our institution between November 2007 and October 2009. 100 mg mifepristone was given orally, followed 24 hours later by 400 micrograms misoprostol vaginally. Misoprostol 400 micrograms was repeated vaginally on the third day if indicated. The primary outcome of complete abortion rate and secondary outcomes of induction-abortion interval and adverse effects, especially bleeding, were assessed.
  
  
  RESULTS
  Mean period of gestation was 38.74±3.90 days. None of the women expelled the products of conception before misoprostol insertion. A second dose of misoprostol was needed in four patients. Complete abortion was achieved in 94.00% of patients, incomplete abortion in 4% and missed abortion in 2%. Approximately all the women reported one or more adverse effects but none of them had any serious ones, the most common being pain in 42 (84%) women followed by nausea, vomiting, fever and diarrhoea in 12 (24%), 6 (12%), 4 (8%) and 3 (6%) women respectively. The overall acceptability rate of the dosing regimen in our study was 94%.
  
  
  CONCLUSIONS
  A regimen of low dose mifepristone (100 mg) followed 24 hours later by vaginal misoprostol can be safely and effectively used for early abortion.
authors.affiliation: Department of Gynaecology, Mmimsr, Mullana, Ambala, Haryana, India.
authors.forename: Anupama
authors.initials: A
authors.lastname: Goel
authors.affiliation: Department of Gynaecology, Mmimsr, Mullana, Ambala, Haryana, India.
authors.forename: Sandhya
authors.initials: S
authors.lastname: Mittal
authors.affiliation: Department of Gynaecology, Mmimsr, Mullana, Ambala, Haryana, India.
authors.forename: Bk
authors.initials: B
authors.lastname: Taneja
authors.affiliation: Department of Gynaecology, Mmimsr, Mullana, Ambala, Haryana, India.
authors.forename: Manisha
authors.initials: M
authors.lastname: Singhal
keywords: Mifepristone; medical abortion; misoprostol