title: Flow pattern analysis in a highly stenotic patient-specific carotid bifurcation model using a turbulence model.
abstract: The aim of this study is to investigate the blood flow pattern in carotid bifurcation with a high degree of luminal stenosis, combining in vivo magnetic resonance imaging (MRI) and computational fluid dynamics (CFD). A newly developed two-equation transitional model was employed to evaluate wall shear stress (WSS) distribution and pressure drop across the stenosis, which are closely related to plaque vulnerability. A patient with an 80% left carotid stenosis was imaged using high resolution MRI, from which a patient-specific geometry was reconstructed and flow boundary conditions were acquired for CFD simulation. A transitional model was implemented to investigate the flow velocity and WSS distribution in the patient-specific model. The peak time-averaged WSS value of approximately 73 Pa was predicted by the transitional flow model, and the regions of high WSS occurred at the throat of the stenosis. High oscillatory shear index values up to 0.50 were present in a helical flow pattern from the outer wall of the internal carotid artery immediately after the throat. This study shows the potential suitability of a transitional turbulent flow model in capturing the flow phenomena in severely stenosed carotid arteries using patient-specific MRI data and provides the basis for further investigation of the links between haemodynamic variables and plaque vulnerability. It may be useful in the future for risk assessment of patients with carotid disease.
authors.affiliation: a School of Biological Science and Medical Engineering, Southeast University , Nanjing 210096 , China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Li
authors.forename: Felicia P P
authors.initials: FP
authors.lastname: Tan
authors.forename: Giulia
authors.initials: G
authors.lastname: Soloperto
authors.forename: Nigel B
authors.initials: NB
authors.lastname: Wood
authors.forename: Xiao Y
authors.initials: XY
authors.lastname: Xu
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Gillard
keywords: MRI; atherosclerosis; luminal stenosis; plaque vulnerability; shear stress