title: Arterial hypertension and posterior reversible cerebral edema syndrome induced by risperidone.
abstract: Posterior reversible cerebral edema syndrome is a generally reversible neurologic condition that is diagnosed based on distinctive clinical and radiologic findings. The condition, which is mostly associated with severe arterial hypertension, has also been reported to be induced by several medications. We made the diagnosis of hypertension with posterior reversible cerebral edema syndrome in a lean 12-year-old girl treated with the second-generation antipsychotic risperidone. We applied the Naranjo Adverse Drug Reaction Probability Scale and the World Health Organization-Uppsala Monitoring Centre system for causality assessment to the present case. Both scales indicated that a relationship to risperidone was likely. Second-generation antipsychotic agents may occasionally induce an increase in blood pressure even in the absence of overweight. Given this possibility, we recommend routine monitoring of blood pressure during therapy with these agents.
authors.affiliation: Pediatric Emergency Department.
authors.forename: Gregorio Paolo
authors.initials: GP
authors.lastname: Milani
authors.forename: Mario Giovanni
authors.initials: MG
authors.lastname: Bianchetti
authors.forename: Marta Benedetta Maria
authors.initials: MB
authors.lastname: Mazzoni
authors.forename: Fabio
authors.initials: F
authors.lastname: Triulzi
authors.forename: Massimo Carlo
authors.initials: MC
authors.lastname: Mauri
authors.forename: Carlo
authors.initials: C
authors.lastname: Agostoni
authors.forename: Emilio Filippo
authors.initials: EF
authors.lastname: Fossali
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D001929:Brain Edema / Q000139:chemically induced* / Q000175:diagnosis; D002648:Child; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000175:diagnosis; D018967:Risperidone / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone
keywords: arterial hypertension; posterior reversible cerebral edema syndrome; risperidone; second-generation antipsychotic drugs