title: Regioselective hydroacylation of 1,3-dienes by cobalt catalysis.
abstract: We describe a cobalt-catalyzed hydroacylation of 1,3-dienes with non-chelating aldehydes. Aromatic aldehydes provide 1,4-addition products as the major isomer, while aliphatic aldehydes favor 1,2-hydroacylation products. The kinetic profile supports an oxidative cyclization mechanism involving a cobaltacycle intermediate that undergoes transformation with high regio- and stereoselectivity.
authors.affiliation: Department of Chemistry, University of California, Irvine , 4403 Natural Sciences 1, Irvine, California 92697, United States.
authors.forename: Qing-An
authors.initials: QA
authors.lastname: Chen
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Kim
authors.forename: Vy M
authors.initials: VM
authors.lastname: Dong
mesh_terms: D000215:Acylation; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D003035:Cobalt / Q000737:chemistry*; D003500:Cyclization; D006841:Hydrocarbons, Aromatic / Q000737:chemistry; D010084:Oxidation-Reduction; D011090:Polyenes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D006841:Hydrocarbons, Aromatic; D011090:Polyenes; D003035:Cobalt