title: Altered activation in visual cortex: unusual functional magnetic resonance imaging finding in early Parkinson's disease.
abstract: OBJECTIVE
  Movement dysfunction in Parkinson's disease (PD) is well documented but its cause remains unclear. This study examined whether motor symptoms are caused by sensory impairment, executive dysfunction or other factors.
  
  
  METHODS
  We examined the integration of tactile and motor programmes using functional magnetic resonance imaging (fMRI) in early stage PD patients compared with neurologically normal controls, to investigate neural mechanisms underlying movement dysfunction.
  
  
  RESULTS
  Twenty-two control participants exhibited activation in an extensive network of cortical regions involved in tactile-motor integration. Decreased activation in somatosensory and motor regions during performance of passive tactile and movement tasks was found in 21 PD patients. The extrastriate visual cortex exhibited greater activation in controls during performance of the tasks. In contrast, greater activation in bilateral prefrontal regions was found in PD patients.
  
  
  CONCLUSIONS
  These results indicate that the extrastriate visual cortex is a multisensory region playing an important role in sensorimotor integration. The findings suggest that PD patients exhibit decreased activation in the extrastriate visual cortex, possibly related to dysfunctional integrative processing, and compensatory activity in the prefrontal cortex.
authors.affiliation: Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
authors.forename: Yilei
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xuning
authors.initials: X
authors.lastname: Zheng
authors.forename: Qidong
authors.initials: Q
authors.lastname: Wang
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Xu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Xu
authors.forename: Minming
authors.initials: M
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D059907:Functional Neuroimaging; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000000981:diagnostic imaging* / Q000502:physiology; D010300:Parkinson Disease / Q000000981:diagnostic imaging*; D011859:Radiography; D013003:Somatosensory Cortex / Q000000981:diagnostic imaging* / Q000502:physiology; D014793:Visual Cortex / Q000000981:diagnostic imaging* / Q000502:physiology
keywords: Parkinson’s disease; movement; multisensory processing; sensorimotor integration; visual cortex