title: Serologic Detection of Anti Toxoplasma gondii Infection in Diabetic Patients.
abstract: BACKGROUND
  Toxoplasmosis is caused by the Toxoplasma gondii parasite. The parasite is intracellular and can result in severe complications leading to death in immuno-deficient patients in particular. Diabetes is an important factor that increases susceptibility and risk of various infections in the host.
  
  
  OBJECTIVE
  The present study focused on the serologic detection of Toxoplasma gondii infection in diabetic patients.
  
  
  METHODS
  Through a case-control study, overall 184 serum samples including 91 from diabetic cases and 93 from healthy non-diabetic controls were investigated. Cases and controls were matched for age and gender. Serum samples were tested for sugar by an enzymatic method, and IgG antibodies were tested against Toxoplasma gondii by ELISA method.
  
  
  RESULTS
  The prevalence of IgG antibodies against Toxoplasma gondii in diabetic patients and healthy controls were 60.43% and 38% respectively. Risk of toxoplasmosis infection in diabetic patients with was two folds higher than healthy controls (RR = 2.21, 95% CI; 1.6 - 3.7, P = 0.001).
  
  
  CONCLUSIONS
  Diabetes may be caused by Toxoplasma gondii. Presence of T. gondii in the pancreas at the same time could directly undermines the pancreas cells. When β cells are destroyed, insulin secretion would then be affected. Probably the destruction of T. gondii affects nervous system and damages pancreatic cells leading to increased risk of diabetes.
authors.affiliation: Department of Parasitology, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Shirbazou
authors.affiliation: Department of Clinical Epidemiology and Prevention of Psychosocial Injuries, Research Centre, Ilam University of Medical Sciences, Ilam, IR Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Delpisheh
authors.affiliation: Department of Parasitology, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
authors.forename: Rahim
authors.initials: R
authors.lastname: Mokhetari
authors.affiliation: Department of Medical Technology, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
authors.forename: Ghafor
authors.initials: G
authors.lastname: Tavakoli
keywords: Diabetes; Infection; Serum; Toxoplasma gondii