title: Resveratrol improves muscle function but not oxidative capacity in young mdx mice.
abstract: Patients with Duchenne muscular dystrophy (DMD) have reduced muscle function due to chronic muscle damage, inflammation, oxidative stress, and reduced oxidative capacity. Resveratrol reduces inflammation and oxidative stress, and increases oxidative capacity in other disease models. The purpose of this study was to determine the effects of resveratrol on muscle function, muscle pathology, and oxidative capacity in young mdx mice. For this, 4- to 5-week-old male mdx mice were randomized into control or resveratrol-treated groups and given resveratrol (100 mg/kg body mass) or an equal volume of water by gavage every other day for 8 weeks. Muscle function was assessed pre- and post-treatment. Central nucleation, total immune cell infiltrate, oxidative stress, and oxidative capacity were measured post-treatment. Resveratrol mediated substantial improvements in rotarod performance and in-situ peak tension by 53% and 17%, respectively, and slight improvements in central nucleation and oxidative stress. Resveratrol did not affect total immune cell infiltrate at 12 weeks of age, and had no effect on oxidative capacity. Resveratrol improves muscle function in mdx mice despite small changes in muscle pathology. The likely mechanism is a resveratrol-mediated reduction in immune cell infiltrate at the early stages of this disease, as previously reported by our laboratory.
authors.affiliation: a Department of Exercise Science, University of South Carolina, Columbia, South Carolina, USA.
authors.forename: Bradley S
authors.initials: BS
authors.lastname: Gordon
authors.forename: Diana C
authors.initials: DC
authors.lastname: Delgado-Diaz
authors.forename: James
authors.initials: J
authors.lastname: Carson
authors.forename: Raja
authors.initials: R
authors.lastname: Fayad
authors.forename: L Britt
authors.initials: LB
authors.lastname: Wilson
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Kostek
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D007249:Inflammation / Q000276:immunology; D008297:Male; D018101:Mice, Inbred mdx; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D009929:Organ Size; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D000077185:Resveratrol; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D013267:Stilbenes / Q000494:pharmacology*; D049411:Utrophin / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D013267:Stilbenes; D049411:Utrophin; D000077185:Resveratrol