title: Primary mucinous adenocarcinoma of the renal pelvis with carcinoma in situ in the ureter.
abstract: Primary epithelial tumor of the renal pelvis is rare and only 100 cases are reported in the literature [1]. Histological examination of the tumor showed glands, cysts, and papillae lined by pseudostratified columnar epithelium with hyperchromatic nuclei. Scattered signet ring-type cells were also seen floating in large pools of extracellular mucin. Sections from the ureter showed a component of adenocarcinoma in situ. No invasive tumor was identified in ureteric tissue. One case was reported with carcinoma in situ of the ureter (2). Immunohistochemically: The tumor showed positivity for CK7, CK20, CK8/18, GATA-3, MSH-2, MSH-6, MLH-1, Ber-EP4, and S-100-P with focal positivity for CDX-2, weak positivity for PMS-2 and negativity in TTF-1 and Her-2. Molecular pathological analysis revealed microsatellite stability and without mutation in K-ras-gene. Thus, a diagnosis of mucinous adenocarcinoma of the renal pelvis with in situ adenocarcinoma of the ureter was made.
authors.affiliation: Departments of Pathology, Hanover Medical School, Hanover, Germany. Electronic address: Mahabbas74@gmail.com.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Abbas
authors.affiliation: Urology and Urologic Oncology, Hanover Medical School, Hanover, Germany.
authors.forename: Mario W
authors.initials: MW
authors.lastname: Kramer
authors.affiliation: Department of Pathology, University of Muenster, Germany.
authors.forename: Tilmann
authors.initials: T
authors.lastname: Spieker
authors.affiliation: Urology and Urologic Oncology, Hanover Medical School, Hanover, Germany.
authors.forename: Thomas R W
authors.initials: TR
authors.lastname: Herrman
authors.affiliation: Urology and Urologic Oncology, Hanover Medical School, Hanover, Germany.
authors.forename: Axel S
authors.initials: AS
authors.lastname: Merseburger
authors.affiliation: Department of Pathology, University of Muenster, Germany.
authors.forename: Klaus-Michael
authors.initials: KM
authors.lastname: Müller
authors.affiliation: Urology and Urologic Oncology, Hanover Medical School, Hanover, Germany.
authors.forename: Marcus A
authors.initials: MA
authors.lastname: Kuczyk
authors.affiliation: Departments of Pathology, Hanover Medical School, Hanover, Germany.
authors.forename: Jan U
authors.initials: JU
authors.lastname: Becker
authors.affiliation: Departments of Pathology, Hanover Medical School, Hanover, Germany.
authors.forename: Hans-Heinrich
authors.initials: HH
authors.lastname: Kreipe
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging* / Q000473:pathology; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D007682:Kidney Pelvis / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging* / Q000473:pathology; D014463:Ultrasonography; D014516:Ureteral Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology
keywords: Adenocarcinoma; Carcinoma in situ; Renal pevis; Ureter