title: Expression of HMGB1 and NF-κB p65 and its significance in non-small cell lung cancer.
abstract: OBJECTIVE
  To study high mobility group protein B1 (HMGB1) and nuclear transcription factor p65 (NF-κB p65) expression in non-small cell lung cancer and its significance.
  
  
  METHODS
  106 hospitalized patients with non-small cell lung cancer after thoracic surgery were enrolled; HMGB1 and p65 protein expression was detected by the immunohistochemical method. Semiquantitative expression of HMGB1 and NF-κB p65 was analyzed using Image Pro Plus (IPP) software and statistical analysis.
  
  
  RESULTS
  The rate of HMGB1 positive expression in the non-small cell lung cancer protein B1 family was significantly higher than normal tissues (P < 0.05); p65 protein expression in the non-small cell lung carcinoma group was significantly higher than that of normal tissues (P < 0.05). HMGB1 and NF-κB p65 protein expression was significantly higher compared with the non-metastatic group (P < 0.01). HMGB1 and NF-κB p65 protein expression showed a positive correlation (P < 0.05).
  
  
  CONCLUSIONS
  HMGB1 and NF-κB p65 expression may be related to non-small cell lung cancer metastasis.
authors.affiliation: Department of Respiratory Medicine, Central Hospital of Zhengzhou, Zhengzhou, China.
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Hongmin
authors.initials: H
authors.lastname: Wang
authors.affiliation: Department of Respiratory Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
keywords: high mobility group protein B1; immunohistochemistry; non-small cell lung cancer; nuclear transcription factor p65; transfer