title: Amiodarone versus lidocaine for the prevention of reperfusion ventricular fibrillation: A randomized clinical trial.
abstract: BACKGROUND
  Reperfusion ventricular fibrillation after aortic cross clamp is one of the important complications of open cardiac surgery and its prevention could reduce myocardial injuries. This study aimed to evaluate the efficacy of single dose of amiodarone or lidocaine by the way of pump circuit three minutes before aortic cross clamp release and compare the results with normal saline as placebo in a randomized double blinded controlled trial.
  
  
  METHODS
  One hundred fifty patients scheduled for first time elective coronary artery bypass graft surgery were randomly assigned to receive either single dose of amiodarone (150 mg), lidocaine (100 mg), or normal saline (5 ml) three minutes before aortic cross clamp release. The incidence of ventricular fibrillation and the need for reuse of drug were compared between these groups by chi-square, Student's t-test, Mann-Whitney test, and One-way ANOVA. SPSS software was used for statistical analysis.
  
  
  RESULTS
  The incidence of ventricular fibrillation is higher in the placebo group (15.9%) compare to lidocaine (11.8%) and amiodarone (8.9%) groups; however, there was no statistical difference among the three groups (P = 0.41). Moreover, the reuse of amiodarone (22.7%) was statistically higher (P < 0.05) than lidocaine (5.9%).
  
  
  CONCLUSIONS
  This study showed no difference among lidocaine, amiodarone, and placebo in preventing ventricular fibrillation after aortic cross clamp release.
authors.affiliation: Associate Professor, Heart Valve Disease Research Center AND Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Alizadeh-Ghavidel
authors.affiliation: Cardiac Surgery Fellow, Heart Valve Disease Research Center AND Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Salaheddin
authors.initials: S
authors.lastname: Nabavi
authors.affiliation: Associate Professor, Cardiac Electrophysiology Research Center AND Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Majid
authors.initials: M
authors.lastname: Haghjoo
authors.affiliation: Associate Professor, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Zia
authors.initials: Z
authors.lastname: Toutonchi
authors.affiliation: Research Fellow, Heart Valve Disease Research Center AND Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Yalda
authors.initials: Y
authors.lastname: Mirmesdagh
authors.affiliation: Research Fellow, Heart Valve Disease Research Center AND Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
authors.forename: Hoda
authors.initials: H
authors.lastname: Javadikasgari
keywords: Amiodarone; Ischemia Reperfusion Injury; Lidocaine; Randomized Controlled Trial; Ventricular Fibrilation