title: Using Rh(III)-catalyzed C-H activation as a tool for the selective functionalization of ketone-containing molecules.
abstract: Due to the strong potential of C-H activation in many areas of organic chemistry, the use of a pre-existing carbonyl group for the installation of a directing group to enable selective and predictable α-alkenylation with activated olefins as coupling partners is described. This Heck-type reaction would then lead either to β,γ-unsaturated ketones or to variously substituted 1,4-butadienes depending on the conditions used for the cleavage of the directing group.
authors.affiliation: Organisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster , Corrensstrasse 40, 48149 Münster, Germany.
authors.forename: Mélissa
authors.initials: M
authors.lastname: Boultadakis-Arapinis
authors.forename: Matthew N
authors.initials: MN
authors.lastname: Hopkinson
authors.forename: Frank
authors.initials: F
authors.lastname: Glorius
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002070:Butadienes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002070:Butadienes; D007659:Ketones; D012238:Rhodium