title: Role of dietary and endogenous antioxidants in diabetes.
abstract: Diabetes affects different people of all ages, race, and sex. This is a condition characterized by a state of chronic hyperglycaemia that leads to an increase of intracellular oxidative stress linked to the overproduction of free radicals. In the present review, we focus our attention on the molecular mechanisms leading to oxidative stress-mediates complications with particular regard to central nervous system (CNS). Furthermore, the present review reports the effects of different kind of antioxidants with enzymatic and nonenzymatic action that may significantly decrease the intracellular free radicals' overproduction and prevents the hyperglycaemia-mediated complications.
authors.affiliation: a Department of Drug Science, Section of Biochemistry , University of Catania , Catanina , Italy.
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Marrazzo
authors.forename: Ignazio
authors.initials: I
authors.lastname: Barbagallo
authors.forename: Fabio
authors.initials: F
authors.lastname: Galvano
authors.forename: Michele
authors.initials: M
authors.lastname: Malaguarnera
authors.forename: Diego
authors.initials: D
authors.lastname: Gazzolo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Frigiola
authors.forename: Nicolantonio
authors.initials: N
authors.lastname: D'Orazio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Li Volti
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage*; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism; D003920:Diabetes Mellitus / Q000188:drug therapy*; D004032:Diet; D004195:Disease Models, Animal; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D018384:Oxidative Stress / Q000187:drug effects
chemical_list: D000975:Antioxidants