title: Ischaemic stroke as initial presentation of systemic malignancy.
abstract: Ischaemic stroke as the initial presentation of systemic malignancy is reported infrequently and is characterised by ischaemic lesions that exceed the vascular territory of a single vessel. There is also a high rate of early stroke recurrence. Several pathophysiological mechanisms are known to cause cerebrovascular complications in malignancies, as a direct effect of the tumour, paraneoplastic or even of the tumour treatment itself. Prognosis is reportedly poor, treatment is symptomatic and at best anecdotal. We present a case report and available literature.
authors.affiliation: Department of Neurology, UMC Utrecht, Utrecht, The Netherlands.
authors.forename: Stephan
authors.initials: S
authors.lastname: Goedee
authors.forename: Alike
authors.initials: A
authors.lastname: Naber
authors.forename: Jörgen M P
authors.initials: JM
authors.lastname: Rovers
authors.forename: Gerwin
authors.initials: G
authors.lastname: Roks
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating; D010051:Ovarian Neoplasms / Q000150:complications / Q000175:diagnosis*; D020521:Stroke / Q000175:diagnosis / Q000209:etiology*