title: Prenatal influences on size, velocity and tempo of infant growth: findings from three contemporary cohorts.
abstract: BACKGROUND
  Studying prenatal influences of early life growth is relevant to life-course epidemiology as some of its features have been linked to the onset of later diseases.
  
  
  METHODS
  We studied the association between prenatal maternal characteristics (height, age, parity, education, pre-pregnancy body mass index (BMI), smoking, gestational diabetes and hypertension) and offspring weight trajectories in infancy using SuperImposition by Translation And Rotation (SITAR) models, which parameterize growth in terms of three biologically interpretable parameters: size, velocity and tempo. We used data from three contemporary cohorts based in Portugal (GXXI, n=738), Italy (NINFEA, n=2,925), and Chile (GOCS, n=959).
  
  
  RESULTS
  Estimates were generally consistent across the cohorts for maternal height, age, parity and pre-pregnancy overweight/obesity. Some exposures only affected one growth parameter (e.g. maternal height (per cm): 0.4% increase in size (95% confidence interval (CI):0.3; 0.5)), others were either found to affect size and velocity (e.g. pre-pregnancy underweight vs normal weight: smaller size (-4.9%, 95% CI:-6.5; -3.3), greater velocity (5.9%, 95% CI:1.9;10.0)), or to additionally influence tempo (e.g. pre-pregnancy overweight/obesity vs normal weight: increased size (7.9%, 95% CI:4.9;10.8), delayed tempo (0.26 months, 95% CI:0.11;0.41), decreased velocity (-4.9%, 95% CI: -10.8;0.9)).
  
  
  CONCLUSIONS
  By disentangling the growth parameters of size, velocity and tempo, we found that prenatal maternal characteristics, especially maternal smoking, pre-pregnancy overweight and underweight, parity and gestational hypertension, are associated with different aspects of infant weight growth. These results may offer insights into the mechanisms governing infant growth.
authors.affiliation: Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Turin, Italy ; Centre for Statistical Methodology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Costanza
authors.initials: C
authors.lastname: Pizzi
authors.affiliation: Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, United Kingdom.
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Cole
authors.affiliation: Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte, Turin, Italy.
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Richiardi
authors.affiliation: Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Isabel
authors.initials: I
authors.lastname: dos-Santos-Silva
authors.affiliation: Institute of Nutrition and Food Technology, University of Chile, Santiago de Chile, Chile.
authors.forename: Camila
authors.initials: C
authors.lastname: Corvalan
authors.affiliation: Centre for Statistical Methodology, London School of Hygiene and Tropical Medicine, London, United Kingdom.
authors.forename: Bianca
authors.initials: B
authors.lastname: De Stavola
mesh_terms: D000328:Adult; D001835:Body Weight; D002657:Child Development; D015331:Cohort Studies; D005260:Female; D057238:Growth Charts; D006801:Humans; D007223:Infant; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D015430:Weight Gain; D055815:Young Adult