title: Comparable autoantibody serum levels against amyloid- and inflammation-associated proteins in Parkinson's disease patients and controls.
abstract: Naturally occurring autoantibodies (NAbs) against a number of potentially disease-associated cellular proteins, including Amyloid-beta1-42 (Abeta1-42), Alpha-synuclein (Asyn), myelin basic protein (MBP), myelin oligodendrocyte glycoprotein (MOG), and S100 calcium binding protein B (S100B) have been suggested to be associated with neurodegenerative disorders, in particular Alzheimer's (AD) and Parkinson's disease (PD). Whereas the (reduced) occurrence of specific NAbs in AD is widely accepted, previous literature examining the relation of these NAb titres between PD patients and controls, as well as comparing these levels with demographic and clinical parameters in PD patients have produced inconsistent findings. We therefore aimed, in a cross-sectional approach, to determine serum titres of the above NAbs in a cohort of 93 PD patients (31 of them demented) and 194 controls. Levels were correlated with demographic and clinical variables, cerebrospinal fluid Abeta1-42, total tau and phospho-tau levels, as well as with single nucleotide polymorphisms (SNPs) of genes which either have been reported to influence the immune system, the amyloid cascade or the occurrence of PD (ApoE, GSK3B, HLA-DRA, HSPA5, SNCA, and STK39). The investigated NAb titres were neither significantly associated with the occurrence of PD, nor with demographic and clinical parameters, neurodegenerative markers or genetic variables. These results argue against a major potential of blood-borne parameters of the adaptive immune system to serve as trait or state markers in PD.
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany ; DZNE, German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany ; DZNE, German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
authors.forename: Anja
authors.initials: A
authors.lastname: Apel
authors.affiliation: Mediagnost, Reutlingen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Langkamp
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany ; DZNE, German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Deuschle
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany ; DZNE, German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
authors.forename: Sarah Selina
authors.initials: SS
authors.lastname: Dilger
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany ; DZNE, German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
authors.forename: Johannes Georg
authors.initials: JG
authors.lastname: Stirnkorb
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany ; DZNE, German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Schulte
authors.affiliation: Department of Internal Medicine IV, University Hospital Tuebingen, Tuebingen, Germany.
authors.forename: Erwin
authors.initials: E
authors.lastname: Schleicher
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany ; DZNE, German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gasser
authors.affiliation: Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany ; DZNE, German Center for Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
mesh_terms: D016229:Amyloid beta-Peptides / Q000097:blood / Q000276:immunology*; D001057:Apolipoproteins E / Q000235:genetics; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D000091342:Endoplasmic Reticulum Chaperone BiP; D004797:Enzyme-Linked Immunosorbent Assay; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics; D000071679:Glycogen Synthase Kinase 3 beta; D059805:HLA-DR alpha-Chains / Q000235:genetics; D006360:Heat-Shock Proteins / Q000235:genetics; D006801:Humans; D004676:Myelin Basic Protein / Q000097:blood / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein / Q000097:blood / Q000276:immunology*; D010300:Parkinson Disease / Q000097:blood / Q000276:immunology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood / Q000276:immunology*; D018709:Statistics, Nonparametric; D051844:alpha-Synuclein / Q000097:blood / Q000235:genetics / Q000276:immunology*
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D001323:Autoantibodies; D000091342:Endoplasmic Reticulum Chaperone BiP; D059805:HLA-DR alpha-Chains; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins; D004676:Myelin Basic Protein; D063308:Myelin-Oligodendrocyte Glycoprotein; D064568:S100 Calcium Binding Protein beta Subunit; C497604:SNCA protein, human; D051844:alpha-Synuclein; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D017346:Protein Serine-Threonine Kinases; C486409:STK39 protein, human; D038362:Glycogen Synthase Kinase 3