title: [Study on early intervention of compound nutrition for cognitive dysfunction in Alzheimer's disease].
abstract: OBJECTIVE
  To observe the early prevention effect of the compound nutrients recipe for cognitive dysfunction of Alzheimer' s disease model-APP-PSN transgenic mouse.
  
  
  METHODS
  36 APP-PSN transgenic mice aged two months randomly were divided into the intervention group supplied with compound recipe in the diet and the control group fed based feed, the former had high dose and low dose, 12 APP-PSN transgenic negative mice aged two months as the negative control were fed based feed. After 3 months' intervention, four groups' cognitive functions were evaluated using the Morris water maze, active avoidance experiment and jumping stair experiment.
  
  
  RESULTS
  There was not statistically different between all the four groups for the weight and food intake. Compared with the control group, Morris water maze's incubation period of the intervention group was lower obviously, and jumping stair experiment's incubation period of the intervention group was higher obviously. In the active avoidance experiment, the high and low dose intervention group' s conditioned response accounted about 46.67% and 45.00% respectively, and the control group's conditioned response accounted about 20.83%. The differences of the three behavioral experiments between control group and intervention group had the statistical significance (P < 0.05), so the same as between control group and negative control group (P < 0.05). And there was no difference between intervention group and negative control group for the three behavioral experiments.
  
  
  CONCLUSIONS
  The early supplementation with compound nutrition could postpone the occurrence and development of Alzheimer' s disease mice model's cognitive dysfunction.
authors.affiliation: College of Public Health, Harbin medical university, Harbin 150081, China. jn6701412@163.com
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.affiliation: College of Public Health, Harbin medical university, Harbin 150081, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xie
authors.affiliation: College of Public Health, Harbin medical university, Harbin 150081, China.
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Zhu
authors.affiliation: College of Public Health, Harbin medical university, Harbin 150081, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Dang
authors.affiliation: College of Public Health, Harbin medical university, Harbin 150081, China.
authors.forename: Decai
authors.initials: D
authors.lastname: Wang
mesh_terms: D000544:Alzheimer Disease / Q000178:diet therapy* / Q000517:prevention & control*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D003072:Cognition Disorders / Q000178:diet therapy* / Q000517:prevention & control*; D004195:Disease Models, Animal; D005260:Female; D005526:Food, Formulated; D008297:Male; D018782:Maze Learning; D051379:Mice; D008822:Mice, Transgenic