title: Sulfonyl fluorides as alternative to sulfonyl chlorides in parallel synthesis of aliphatic sulfonamides.
abstract: Two types of aliphatic sulfonyl halides (Cl versus F) were compared in parallel synthesis of sulfonamides derived from aliphatic amines. Aliphatic sulfonyl fluorides showed good results with amines bearing an additional functionality, while the corresponding chlorides failed. Both sulfonyl halides were effective in the reactions with amines having an easily accessible amino group. Aliphatic sulfonyl chlorides reacted efficiently with amines bearing sterically hindered amino group while the corresponding fluorides showed low activity.
authors.affiliation: Enamine, Ltd. , 23 Matrosova Street, Kyiv, 01103, Ukraine.
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Bogolubsky
authors.forename: Yurii S
authors.initials: YS
authors.lastname: Moroz
authors.forename: Pavel K
authors.initials: PK
authors.lastname: Mykhailiuk
authors.forename: Sergey E
authors.initials: SE
authors.lastname: Pipko
authors.forename: Anzhelika I
authors.initials: AI
authors.lastname: Konovets
authors.forename: Irina V
authors.initials: IV
authors.lastname: Sadkova
authors.forename: Andrey
authors.initials: A
authors.lastname: Tolmachev
mesh_terms: D015394:Molecular Structure; D013441:Sulfinic Acids / Q000737:chemistry*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D013441:Sulfinic Acids; D013449:Sulfonamides; C048899:sulfuryl fluoride; C044255:sulfonyl chloride