title: PdCl2 catalyzed efficient assembly of organic azides, CO, and alcohols under mild conditions: a direct approach to synthesize carbamates.
abstract: A simple and readily available PdCl2 catalyzed carbamate synthesis method via isocyanate generation and application in situ has been developed. This chemistry provides an efficient and practical approach to synthesize carbamates from simple organic azides, CO atmosphere and alcohols. The broad scope, mild and neutral conditions, and only N2 as the byproduct make this transformation very useful. Moreover, simple examples of modification of bioactive molecules and construction of macrocycles were achieved through this protocol.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Rd. 38, Beijing 100191, People's Republic of China. jiaoning@bjmu.edu.cn.
authors.forename: Long
authors.initials: L
authors.lastname: Ren
authors.forename: Ning
authors.initials: N
authors.lastname: Jiao
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002219:Carbamates / Q000138:chemical synthesis*; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D017953:Isocyanates / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D001386:Azides; D002219:Carbamates; D017953:Isocyanates; D010165:Palladium; D002248:Carbon Monoxide; C008756:palladium chloride