title: Structurally defined nanoscale sheets from self-assembly of collagen-mimetic peptides.
abstract: We report the design of two collagen-mimetic peptide sequences, NSI and NSII, that self-assemble into structurally defined nanoscale sheets. The underlying structure of these nanosheets can be understood in terms of the layered packing of collagen triple helices in two dimensions. These nanosheet assemblies represent a novel morphology for collagen-based materials, which, on the basis of their defined structure, may be envisioned as potentially biocompatible platforms for controlled presentation of chemical functionality at the nanoscale. The molecularly programmed self-assembly of peptides NSI and NSII into nanosheets suggests that sequence-specific macromolecules offer significant promise as design elements for two-dimensional (2D) assemblies. This investigation provides a design rubric for fabrication of structurally defined, peptide-based nanosheets using the principles of solution-based self-assembly facilitated through complementary electrostatic interactions.
authors.affiliation: Department of Chemistry, Emory University , Atlanta, Georgia 30322.
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Chunfu
authors.initials: C
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Wall
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zuo
authors.forename: Tianquan
authors.initials: T
authors.lastname: Lian
authors.forename: Khalid
authors.initials: K
authors.lastname: Salaita
authors.forename: Chaoying
authors.initials: C
authors.lastname: Ni
authors.forename: Darrin
authors.initials: D
authors.lastname: Pochan
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Conticello
mesh_terms: D000595:Amino Acid Sequence; D003094:Collagen / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008969:Molecular Sequence Data; D010316:Particle Size; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D013499:Surface Properties
chemical_list: D010455:Peptides; D006046:Gold; D003094:Collagen