title: Statistical mechanics model for the dynamics of collective epigenetic histone modification.
abstract: Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes.
authors.affiliation: Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061-0406, USA.
authors.forename: Hang
authors.initials: H
authors.lastname: Zhang
authors.affiliation: Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061-0406, USA.
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Tian
authors.affiliation: Department of Physics, Virginia Tech, Blacksburg, Virginia 24061-0406, USA.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Mukhopadhyay
authors.affiliation: Lawrence Livermore National Laboratory and University of California, Livermore, California 94550, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Kim
authors.affiliation: Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia 24061-0406, USA and Department of Physics, Virginia Tech, Blacksburg, Virginia 24061-0406, USA and Beijing Computational Science Research Center, Beijing 100084, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Xing
mesh_terms: D057890:Epigenomics; D006657:Histones / Q000235:genetics* / Q000378:metabolism; D008239:Lysine / Q000235:genetics / Q000378:metabolism; D008745:Methylation; D008957:Models, Genetic; D015233:Models, Statistical; D009707:Nucleosomes / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D050814:Octamer Transcription Factor-3 / Q000235:genetics; D013269:Stochastic Processes; D013816:Thermodynamics
chemical_list: D006657:Histones; D009707:Nucleosomes; D050814:Octamer Transcription Factor-3; D008239:Lysine