title: Invoking the power of thrombospondins: regulation of thrombospondins expression.
abstract: Increasing evidence suggests critical functions of thrombospondins (TSPs) in a variety of physiological and pathological processes. With the growing understanding of the importance of these matricellular proteins, the need to understand the mechanisms of regulation of their expression and potential approaches to modulate their levels is also increasing. The regulation of TSP expression is multi-leveled, cell- and tissue-specific, and very precise. However, the knowledge of mechanisms modulating the levels of TSPs is fragmented and incomplete. This review discusses the known mechanisms of regulation of TSP levels and the gaps in our knowledge that prevent us from developing strategies to modulate the expression of these physiologically important proteins.
authors.affiliation: Department of Molecular Cardiology, Cleveland Clinic, 9500 Euclid Ave NB50, Cleveland, OH 44195, United States. Electronic address: stenino@ccf.org.
authors.forename: Olga
authors.initials: O
authors.lastname: Stenina-Adognravi
mesh_terms: D017398:Alternative Splicing / Q000502:physiology*; D000818:Animals; D001483:Base Sequence; D004622:Embryo, Mammalian / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D015676:Osteonectin / Q000378:metabolism; D017434:Protein Structure, Tertiary; D013045:Species Specificity; D019063:Tenascin / Q000378:metabolism; D019699:Thrombospondins / Q000235:genetics / Q000378:metabolism*
chemical_list: D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D015676:Osteonectin; C577241:SPARC protein, human; D019063:Tenascin; D019699:Thrombospondins
keywords: Regulation of expression; Thrombospondin; Transcription; Translation; miRNA