title: Microwave assistance of labeling hippuric acid by I-131.
abstract: This work presents a novel approach for labeling hippuric acid with I-131 using microwaves. It utilizes copper(II) acetate as a catalyst of the labeling. The process involves the use of this catalytic copper(II) acetate at low dilutions that were nevertheless sufficient to produce labeled hippuric acid with high radiochemical purity in a short time. Therefore, the novel technique overcomes the limitations of previously reported conventional methods that involve heating.
authors.affiliation: Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan; Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Lin-Chiang
authors.initials: LC
authors.lastname: Sherlock Huang
authors.affiliation: Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Kou-Hung
authors.initials: KH
authors.lastname: Wu
authors.affiliation: Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Pi-Wen
authors.initials: PW
authors.lastname: Ko
authors.affiliation: Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan; Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Cheng-Ying
authors.initials: CY
authors.lastname: Hsieh
authors.affiliation: Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Kuan-Chuan
authors.initials: KC
authors.lastname: Pao
authors.affiliation: Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Shih-Ching
authors.initials: SC
authors.lastname: Chou
authors.affiliation: Department of Chemistry, National Central University, Chungli 32001, Taiwan.
authors.forename: Fa-Kuen
authors.initials: FK
authors.lastname: Shieh
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
authors.forename: Radhakrishnan
authors.initials: R
authors.lastname: Sureshbabu
authors.affiliation: Nuclear Science & Technology Development Center, National Tsing Hua University, Hsinchu 30013, Taiwan. Electronic address: mhhsu@mx.nthu.edu.tw.
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Hsu
mesh_terms: D002384:Catalysis; D007457:Iodine Radioisotopes / Q000737:chemistry*; D007465:Iodohippuric Acid / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods; D008872:Microwaves; D009942:Organometallic Compounds / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D007457:Iodine Radioisotopes; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D007465:Iodohippuric Acid; C015092:cupric acetate
keywords: Copper(II) acetate; Hippuric acid; I(131) labeling; Microwave; Radiochemical purity