title: The clinical features of infantile hypertrophic pyloric stenosis in Chinese Han population: analysis from 1998 to 2010.
abstract: OBJECTIVE
  To investigate clinical features of infantile hypertrophic pyloric stenosis (IHPS) in Chinese Han population.
  
  
  METHODS
  Three hundred and sixteen hospitalized patients with IHPS from January 1998 to February 2010 were retrospectively reviewed, and data including patient's sex, onset age, other coexisting congenital defects, pyloric circular muscle thickness evaluated by ultrasonograph, serum electrolytes concentration, and results of arterial blood gas analysis on admission were collected. The patients were divided into two groups: the duration between first onset and admission less than or equal to 10 days (early onset group), and more than 10 days (late onset group). The results of arterial blood gas and serum electrolyte concentration were compared between the two groups.
  
  
  RESULTS
  There were 271 males and 45 females in 316 patients; the onset age ranged between 1 and 351 (26.5±26.6) days. The birth weight ranged between 1.6 and 4.5 (3.23±0.44) kilograms; coexisting congenital defects were found in 65 cases (20.6%). Pyloric circular muscle thickness was 4-8 (5.4±1.0) millimetres (mm). For the early onset group, the rates of hypokalemia, hypochloraemia and hypercapnia were significantly lower than those in the late onset group (18.67% VS 50%, P<0.0001; 46.03% VS 71.01%, P = 0.003; 56.58% VS 83.44%, P = 2.17×10(-5); respectively).
  
  
  CONCLUSIONS
  The symptom duration in Chinese Han population was longer than that in other populations. And as the prolongation of symptom duration, the incidence of acid-base imbalance increased significantly. Infants with persistent vomiting at the age of 3∼5 weeks after birth should be considered IHPS, and go to hospital as soon as possible in order to reduce the incidence of hypokalemia, hypochloraemia and hypercapnia, and avoid deterioration.
authors.affiliation: Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China ; Guangzhou Key Laboratory of Digestive Disease, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Feng
authors.affiliation: Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China ; Guangzhou Key Laboratory of Digestive Disease, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Yuqiang
authors.initials: Y
authors.lastname: Nie
authors.affiliation: Department of Pediatrics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Youxiang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Gastroenterology, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China ; Guangzhou Key Laboratory of Digestive Disease, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
authors.forename: Qingning
authors.initials: Q
authors.lastname: Li
authors.affiliation: Department of Surgery, Guangzhou Women and Children's Medical Center, Guangzhou, China.
authors.forename: HuiMing
authors.initials: H
authors.lastname: Xia
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, China.
authors.forename: SiTang
authors.initials: S
authors.lastname: Gong
authors.affiliation: Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, China.
authors.forename: Hai
authors.initials: H
authors.lastname: Huang
mesh_terms: D000015:Abnormalities, Multiple / Q000453:epidemiology; D017668:Age of Onset; D001722:Birth Order; D001724:Birth Weight; D002681:China / Q000453:epidemiology; D004065:Digestive System Abnormalities / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D046248:Pyloric Stenosis, Hypertrophic / Q000151:congenital / Q000175:diagnosis* / Q000453:epidemiology*; D012189:Retrospective Studies