title: Acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.
abstract: The purpose of the study was to highlight the acute motor reflex adaptation and to deepen functional deficits following a middle cerebral artery occlusion-reperfusion (MCAO-r). Thirty-six Sprague-Dawley rats were included in this study. The middle cerebral artery occlusion (MCAO; 120 min) was performed on 16 rats studied at 1 and 7 days, respectively (MCAO-D1 and MCAO-D7, n = 8 for each group). The other animals were divided into 3 groups: SHAM-D1 (n = 6), SHAM-D7 (n = 6) and Control (n = 8). Rats performed 4 behavioral tests (the elevated body swing test, the beam balance test, the ladder-climbing test and the forelimb grip force) before the surgery and daily after MCAO-r. H-reflex on triceps brachii was measured before and after isometric exercise. Infarction size and cerebral edema were respectively assessed by histological (Cresyl violet) and MRI measurements at the same time points than H-reflex recordings. Animals with cerebral ischemia showed persistent functional deficits during the first week post-MCAO-r. H-reflex was not decreased in response to isometric exercise one day after the cerebral ischemia contrary to the other groups. The motor reflex regulation was recovered 7 days post-MCAO-r. This result reflects an acute sensorimotor adaptation at the spinal level after MCAO-r.
authors.affiliation: Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Faculté des Sciences du Sport, Marseille, France ; Université de Nice Sophia-Antipolis et Université du Sud Toulon-Var, Motricité Humaine Éducation Sport Santé, Nice, France.
authors.forename: Caroline
authors.initials: C
authors.lastname: Pin-Barre
authors.affiliation: Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Faculté des Sciences du Sport, Marseille, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Laurin
authors.affiliation: Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Faculté des Sciences du Sport, Marseille, France.
authors.forename: Marie-Solenne
authors.initials: MS
authors.lastname: Felix
authors.affiliation: Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Faculté des Sciences du Sport, Marseille, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Pertici
authors.affiliation: Aix-Marseille Université, Centre National de la Recherche Scientifique, Centre de Résonance Magnétique Biologique et Médicale, Faculté de Médecine Timone, Marseille, France.
authors.forename: Frank
authors.initials: F
authors.lastname: Kober
authors.affiliation: Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Faculté des Sciences du Sport, Marseille, France.
authors.forename: Tanguy
authors.initials: T
authors.lastname: Marqueste
authors.affiliation: Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Institut de Neurobiologie de la Méditerranée, Marseille, France.
authors.forename: Valery
authors.initials: V
authors.lastname: Matarazzo
authors.affiliation: Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale, Institut de Neurobiologie de la Méditerranée, Marseille, France.
authors.forename: Françoise
authors.initials: F
authors.lastname: Muscatelli-Bossy
authors.affiliation: Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Faculté des Sciences du Sport, Marseille, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Temprado
authors.affiliation: Université de Nice Sophia-Antipolis et Université du Sud Toulon-Var, Motricité Humaine Éducation Sport Santé, Nice, France.
authors.forename: Jeanick
authors.initials: J
authors.lastname: Brisswalter
authors.affiliation: Aix-Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Mouvement, Faculté des Sciences du Sport, Marseille, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Decherchi
mesh_terms: D000818:Animals; D006181:H-Reflex / Q000502:physiology; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology*; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015424:Reperfusion