title: Selecting targets from eukaryotic parasites for structural genomics and drug discovery.
abstract: The selection of targets is the first step for any structural genomics project. The application of structural genomics approaches to drug discovery also starts with the selection of targets. Here, three protocols are described that were developed to select targets from eukaryotic pathogens. These protocols could also be applied to other drug discovery projects.
authors.affiliation: Seattle Structural Genomics Center for Infectious Disease, Seattle, WA, USA.
authors.forename: Isabelle Q H
authors.initials: IQ
authors.lastname: Phan
authors.forename: Robin
authors.initials: R
authors.lastname: Stacy
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Myler
mesh_terms: D000818:Animals; D019295:Computational Biology; D055808:Drug Discovery / Q000379:methods*; D056890:Eukaryota / Q000235:genetics*; D023281:Genomics / Q000379:methods; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D010271:Parasites / Q000235:genetics / Q000472:pathogenicity; D011487:Protein Conformation