title: MicroRNA in diabetic nephropathy: renin angiotensin, aGE/RAGE, and oxidative stress pathway.
abstract: MicroRNAs (miRNA) are a novel class of small, noncoding RNA molecules that have gained the attention of many researchers in recent years due to their ability to posttranscriptionally regulate the expression of families of genes simultaneously. Their role in normal physiology and pathobiology is intriguing and their regulation in normal and disease states is fascinating. That the cells can return to a state of homeostasis when these small molecules are perturbed is truly remarkable given the multiple cellular targets of each miRNA and that many mRNAs are targeted by multiple miRNAs. Several reviews have covered aspects of miRNA function in biology and disease. Here, we review the role of miRNA in regulating the renin-angiotensin system, AGE/RAGE signalling, and under conditions of oxidative stress in the context of diabetic nephropathy.
authors.affiliation: JDRF Danielle Alberti Memorial Centre for Diabetes Complications, Diabetes Division, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia ; Division of Nephrology, Department of Internal Medicine, Faculty of Medicine, Juntendo University, Tokyo 113-8421, Japan.
authors.forename: Shinji
authors.identifier: 0000-0002-3125-4842
authors.initials: S
authors.lastname: Hagiwara
authors.affiliation: JDRF Danielle Alberti Memorial Centre for Diabetes Complications, Diabetes Division, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.
authors.forename: Aaron
authors.identifier: 0000-0002-1957-7905
authors.initials: A
authors.lastname: McClelland
authors.affiliation: JDRF Danielle Alberti Memorial Centre for Diabetes Complications, Diabetes Division, Baker IDI Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC 3004, Australia.
authors.forename: Phillip
authors.identifier: 0000-0001-6260-1643
authors.initials: P
authors.lastname: Kantharidis
mesh_terms: D000818:Animals; D003928:Diabetic Nephropathies / Q000235:genetics* / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000502:physiology*; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D017127:Glycation End Products, Advanced; D035683:MicroRNAs; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic