title: Elevated expression of miR-210 predicts poor survival of cancer patients: a systematic review and meta-analysis.
abstract: BACKGROUND
  MiRNAs are important regulators of different biological processes, including tumorigenesis. MiR-210 is a potential prognostic factor for survival in patients with cancer according to previous clinical researches. We conducted a systematic review and meta-analysis to summarize the significance of increased miR-210 expression in the prognosis of indicated cancers.
  
  
  RESULTS
  The present systematic review and meta-analysis of 16 researches included 1809 patients with 7 different types of cancers from 7 countries, and aimed to explore the association between miR-210 expression and the survival of cancer patients. Over-expression of miR-210 may predict poor overall survival (OS, HR = 1.33, 95% CI: 0.85-2.09, P = 0.210), but the effect was not significant. While the predictive effect on disease-free survival (DFS, HR = 1.89, 95% CI: 1.30-2.74, P = 0.001), progression-free survival (PFS, HR = 1.20, 95% CI: 1.05-1.38, P = 0.007) and relapse-free survival(RFS, HR = 4.42, 95% CI: 2.14-9.15, P = 0.000) for patients with breast cancer, primary head and neck squamous cell carcinoma (HNSCC), renal cancer, soft-tissue sarcoma, pediatric osteosarcoma, bladder cancer or glioblastoma was certain. Subgroup analysis showed the limited predictive effect of over-expressed miR-210 on breast cancer OS (HR = 1.63, 95% CI: 0.47-5.67, P = 0.443), breast cancer DFS (HR = 2.03, 95% CI: 0.90-4.57, P = 0.088), sarcoma OS (HR = 1.24, 95% CI: 0.20-7.89, P = 0.818) and renal cancer OS (HR = 1.16, 95% CI: 0.27-4.94, P = 0.842).
  
  
  CONCLUSIONS
  This systematic review and meta-analysis suggests that miR-210 has a predictive effect on survival of patients with studied cancer types as indexed by disease-free survival, progression-free survival and relapse-free survival. While the predictive effect on overall survival, breast cancer overall survival, breast cancer disease-free survival, sarcoma overall survival and renal cancer overall survival was not statistically significant.
authors.affiliation: Institute of Toxicology, School of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
authors.affiliation: Institute of Toxicology, School of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors.forename: Jiqing
authors.initials: J
authors.lastname: Zhao
authors.affiliation: Institute of Toxicology, School of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors.forename: Mengjing
authors.initials: M
authors.lastname: Shi
authors.affiliation: Department of nephrology, Xinqiao Hospital, Chongqing, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Ding
authors.affiliation: Institute of Toxicology, School of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors.forename: Huiqin
authors.initials: H
authors.lastname: Sun
authors.affiliation: Department of nephrology, Xinqiao Hospital, Chongqing, China.
authors.forename: Fahuan
authors.initials: F
authors.lastname: Yuan
authors.affiliation: Institute of Toxicology, School of Preventive Medicine, Third Military Medical University, Chongqing, China.
authors.forename: Zhongmin
authors.initials: Z
authors.lastname: Zou
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000401:mortality*; D011379:Prognosis; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; C543800:MIRN210 microRNA, human; D035683:MicroRNAs