title: Inclusion of piroxicam in mesoporous phosphate glass-ceramic and evaluation of the physiochemical characteristics.
abstract: The mesoporous glass-ceramic (GC) was employed as a carrier to investigate its capability for pharmaceutical applications. Piroxicam (PX) as a model drug was loaded in the GC by using of solvent evaporation technique. The physicochemical properties and morphology of the powders were evaluated employing X-ray powder diffractometry (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), and scanning electron microscopy (SEM). The drug adsorption isotherms were assessed as well. Drug release profiles were examined by fitting the data to the 10 common kinetic models. The specific surface area, Vm (the volume of the N2 adsorbed on the 1g of the GC when the monolayer is complete) and the average pore diameter of the GC powder before and after loading process were measured by the Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH) analysis benefiting N2 adsorption/desorption isotherms. The ideal loading of PX in the GC was 41.8%. The average pore diameter for the GC was determined to be about 10nm. The Freundlich model was found to be the best adsorption isotherm. Decrease of the GC specific surface area and Vm values were observed after loading process. Drug release data were best fitted to the Weibull model with the shape factor of 0.4-0.7 signifying the Fickian diffusion of PX from the GC. Accordingly, the GC could be considered as a suitable adsorbent to develop an oral drug delivery system.
authors.affiliation: Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Yousef
authors.initials: Y
authors.lastname: Javadzadeh
authors.affiliation: Student Research Committee and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Rahimeh
authors.initials: R
authors.lastname: Bairami Atashgah
authors.affiliation: Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Barzegar-Jalali
authors.affiliation: Materials and Energy Research Center, Karaj, Iran.
authors.forename: Farshad
authors.initials: F
authors.lastname: Soleimani
authors.affiliation: Novel Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
authors.forename: Ghobad
authors.initials: G
authors.lastname: Mohammadi
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Araz
authors.initials: A
authors.lastname: Sabzevari
authors.affiliation: Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: adibkia@tbzmed.ac.ir.
authors.forename: Khosro
authors.initials: K
authors.lastname: Adibkia
mesh_terms: D002516:Ceramics / Q000737:chemistry*; D002627:Chemistry, Physical; D005898:Glass / Q000737:chemistry; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry*; D010894:Piroxicam / Q000737:chemistry*; D016062:Porosity; D013499:Surface Properties
chemical_list: D010710:Phosphates; D010894:Piroxicam
keywords: Adsorption/desorption isotherms; BET; Glass–ceramic; Mesoporous; Physicochemical characterization; Piroxicam