title: Extracting brain regions from rest fMRI with total-variation constrained dictionary learning.
abstract: Spontaneous brain activity reveals mechanisms of brain function and dysfunction. Its population-level statistical analysis based on functional images often relies on the definition of brain regions that must summarize efficiently the covariance structure between the multiple brain networks. In this paper, we extend a network-discovery approach, namely dictionary learning, to readily extract brain regions. To do so, we introduce a new tool drawing from clustering and linear decomposition methods by carefully crafting a penalty. Our approach automatically extracts regions from rest fMRI that better explain the data and are more stable across subjects than reference decomposition or clustering methods.
authors.affiliation: Parietal Team, INRIA Saclay-Ile-de-France, Saclay, France. alexandre.abraham@inria.fr
authors.forename: Alexandre
authors.initials: A
authors.lastname: Abraham
authors.affiliation: Parietal Team, INRIA Saclay-Ile-de-France, Saclay, France.
authors.forename: Elvis
authors.initials: E
authors.lastname: Dohmatob
authors.affiliation: Parietal Team, INRIA Saclay-Ile-de-France, Saclay, France.
authors.forename: Bertrand
authors.initials: B
authors.lastname: Thirion
authors.affiliation: Stony Brook University, NY 11794, USA.
authors.forename: Dimitris
authors.initials: D
authors.lastname: Samaras
authors.affiliation: Parietal Team, INRIA Saclay-Ile-de-France, Saclay, France.
authors.forename: Gael
authors.initials: G
authors.lastname: Varoquaux
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity