title: Iron, folate and vitamin B12 levels in first trimester pregnancies in the Southwest region of Turkey.
abstract: OBJECTIVE
  Iron, folate and vitamin B12 play important roles in the healthy development of the fetus in pregnancy. Preconceptional levels of these micronutrients is influenced by dietary habits. The purpose of this study was to investigate the status of iron, vitamin B12 and folate in first trimester pregnancies in the southwest region of Turkey where the Mediterranean Cuisine, rich in fresh fruit and vegetables is commonly consumed.
  
  
  METHODS
  Two hundred and one low-middle income pregnant women were recruited during their first prenatal visit. Hemoglobin, ferritin, folate and vitamin B12 levels were evaluated and a structured questionnaire was given to gather information including age, gravida, parity, frequency of pregnancy, history of abortion, and intrauterine device usage. Based on WHO and international guidelines, anemia was defined as hemoglobin <11 g/dl, and iron deficiency as ferritin <15 μg/L. Serum folate and vitamin B12 deficiencies were defined as levels below 3 ng/ml and 200 pg/ml respectively.
  
  
  RESULTS
  The mean age and gestational week were 26.4±5.3 years and 9±3 weeks respectively. Mean plasma concentrations were 12.8±9.7 g/dl for hemoglobin, 22.7±17.2 μg/L for ferritin, 12.2±5.6 ng/ml for folate and 266.6±100.2 pg/ml for vitamin B12. Anemia was detected in 4.5% of pregnant women, iron deficiency in 40.3%, vitamin B12 deficiency in 29.8% and folate deficiency in 0.5% of patients. In 10.9% of patients, both vitamin B12 and iron iron deficiency was detected. There was no significant difference for age, body mass index, gravida, parity, frequency of pregnancy, history of abortion, and intrauterine device usage between women with low and normal levels of vitamin B12 and Ferritin (p>0.05).
  
  
  CONCLUSIONS
  Iron and vitamin B12 deficiencies were relatively common in the pregnant population consuming vegetable based diets. Iron and vitamin B12 supplementation in addition to folate must be considered for the wellbeing of the fetus in pregnant women living in areas where dietary patterns are mainly vegetable based.
authors.affiliation: Clinic of Obstetrics and Gynecology, Denizli State Hospital, Denizli, Turkey.
authors.forename: Aysun
authors.initials: A
authors.lastname: Karabulut
authors.affiliation: Clinic of Obstetrics and Gynecology, Denizli State Hospital, Denizli, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Sevket
authors.affiliation: Department of Biochemistry, Denizli State Hospital, Denizli, Turkey.
authors.forename: Ayhan
authors.initials: A
authors.lastname: Acun
keywords: Hemoglobin; ferritin; folate; pregnancy; vitamin B12