title: Post-transcriptional regulation of cytokine mRNA controls the initiation and resolution of inflammation.
abstract: Cytokines are critical mediators of inflammation and host defense. Cytokine production is regulated during transcription and post-transcription. Post-transcriptional regulation modifies mRNA stability and translation, allowing for the rapid and flexible control of gene expression, which is important for coordinating the initiation and resolution of inflammation. We review here a variety of post-transcriptional control mechanisms that regulate inflammation and discuss how these mechanisms are integrated to coordinate this essential process.
authors.affiliation: a Laboratory of Infection and Prevention, Department of Biological Responses , Institute for Virus Research, Kyoto University , Kyoto , Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Mino
authors.forename: Osamu
authors.initials: O
authors.lastname: Takeuchi
mesh_terms: D006801:Humans; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D007249:Inflammation / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D012260:Ribonucleases / Q000235:genetics / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D020871:RNA Stability / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D014157:Transcription Factors
chemical_list: D016207:Cytokines; D012260:Ribonucleases; D012333:RNA, Messenger; C510646:ZC3H12A protein, human; D014157:Transcription Factors