title: Cyanoacrylate tissue adhesive on a polyglactin scaffold in strabismus surgery: a laboratory study.
abstract: BACKGROUND
  The use of cyanoacrylate tissue adhesives in strabismus surgery has been variously successful, depending primarily on achieving adequate bond strength and minimizing extraocular muscle slippage. We investigate a novel approach to this problem, involving cyanoacrylate tissue adhesive on a polyglactin 910 scaffold as a means to secure extraocular muscle to the sclera for strabismus surgery.
  
  
  METHODS
  In this experimental laboratory study, butyl-cyanoacrylate was used to fix a polyglactin 910 scaffold to the sclera of cadaver eyes. After allowing for polymerization, a force was applied to the mesh until the polyglactin-sclera bond failed. The maximum load (g) required for bond failure was recorded. The effects of surface area of the polyglactin 910 mesh as well as time required for cyanoacrylate tissue adhesive polymerization on bond strength were investigated.
  
  
  RESULTS
  All combination of variables tested, except for experiments involving polyglactin 910 mesh that is 30 mm(2) with a polymerization time of 15 seconds or 30 seconds and polyglactin 910 mesh that is 40 mm(2) with a polymerization time of 15 seconds, achieved a bond strength that was significantly greater than those forces seen in a physiologic setting (P > 0.05). Increasing area or time resulted in increasing bond strength. Area and time were found to be independent variables.
  
  
  CONCLUSIONS
  The cyanoacrylate tissue adhesive-derived polyglactin-sclera bond achieved a maximum load greater than those seen in a physiologic setting. Our novel approach demonstrates a clinically feasible alternative to traditional means for bonding muscle to sclera in strabismus surgery.
authors.affiliation: Department of Ophthalmology, Queen's University, Kingston, Ontario, Canada. Electronic address: bonamark01@gmail.com.
authors.forename: Mark D
authors.initials: MD
authors.lastname: Bona
authors.affiliation: Department of Ophthalmology, Queen's University, Kingston, Ontario, Canada.
authors.forename: Brian W
authors.initials: BW
authors.lastname: Arthur
mesh_terms: D004659:Enbucrilate / Q000627:therapeutic use*; D006801:Humans; D009801:Oculomotor Muscles / Q000601:surgery*; D011098:Polyglactin 910; D058105:Polymerization; D012590:Sclera / Q000187:drug effects*; D013285:Strabismus / Q000601:surgery*; D013314:Stress, Mechanical; D013526:Surgical Mesh; D013536:Suture Techniques; D013718:Tensile Strength; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D014014:Tissue Adhesives; D011098:Polyglactin 910; D004659:Enbucrilate