title: Highly conjugated norditerpenoid and pyrroloquinoline alkaloids with potent PTP1B inhibitory activity from Nigella glandulifera.
abstract: Three norditerpenoid alkaloids, nigelladines A-C (1-3), and one pyrroloquinoline alkaloid, nigellaquinomine (4), all possessing new skeletons with highly conjugated systems, were isolated from Nigella glandulifera. The 8aS-configuration for 1 and 2 was determined by comparison of the experimental and calculated electronic circular dichroism spectra. These alkaloids exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity but are devoid of cytotoxicity against the A431 cell line at 100 μM.
authors.affiliation: The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011, People's Republic of China.
authors.forename: Qi-Bin
authors.initials: QB
authors.lastname: Chen
authors.forename: Xue-Lei
authors.initials: XL
authors.lastname: Xin
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Shoei-Sheng
authors.initials: SS
authors.lastname: Lee
authors.forename: H A
authors.initials: HA
authors.lastname: Aisa
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D031844:Nigella / Q000737:chemistry*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors*; D011758:Pyrroles; D011804:Quinolines
chemical_list: D000470:Alkaloids; D004224:Diterpenes; D011758:Pyrroles; D011804:Quinolines; C000589638:nigelladine A; C000589639:nigelladine B; C000589640:nigelladine C; C410406:pyrroloquinoline; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1