title: Vitamin D and diabetes.
abstract: There has been increasing evidence that vitamin D may have a role in modifying risk of diabetes. Vitamin D has both direct and indirect effects on various mechanisms related to the pathophysiology of type 2 diabetes, including pancreatic beta cell dysfunction, impaired insulin action and systemic inflammation. This article describes the biologic plausibility behind the potential association between vitamin D and type 2 diabetes and summarizes the current evidence from human studies that suggests but does not prove a relation between vitamin D and type 2 diabetes, and briefly reports on the potential association between vitamin D and type 1 diabetes.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Prima CARE Medical Center, 277 Pleasant Street, Fall River, MA 02721, USA. Electronic address: joannamitri@hotmail.com.
authors.forename: Joanna
authors.initials: J
authors.lastname: Mitri
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, 800 Washington Street, Boston, MA 02111, USA.
authors.forename: Anastassios G
authors.initials: AG
authors.lastname: Pittas
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000517:prevention & control; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000517:prevention & control; D006801:Humans; D014807:Vitamin D / Q000494:pharmacology / Q000502:physiology*
chemical_list: D014807:Vitamin D
keywords: 25-hydroxyvitamin D; Insulin resistance; Insulin sensitivity; Type 2 diabetes; Vitamin D