title: [Protective function of sigma-1 receptor in spinal cord motor neurons].
abstract: Sigma-1 receptor plays a protective function in various tissues. It was shown recently that a mutation in the sigma-1 receptor results in appearance of Amyotrophic Lateral Sclerosis (ALS). In the central nervous system (CNS) the highest amounts of sigma-1 receptor are found in motoneurons of the spinal cord, where receptor is localized in subsurface cisternae of cholinergic postsynaptic densities. The sigma-1 receptor is thought to regulate the ion channels activity and thus may influence neuron excitability. In this review we consider the possible pathways by which the sigma-1 receptor may reduce the excitability of motoneurons and thereby play a protective function during the progression of ALS.
authors.forename: T A
authors.initials: TA
authors.lastname: Mavliutov
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D002490:Central Nervous System / Q000378:metabolism; D006801:Humans; D009046:Motor Neurons / Q000378:metabolism / Q000473:pathology; D009154:Mutation; D017480:Receptors, sigma / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism; D000097605:Sigma-1 Receptor
chemical_list: D017480:Receptors, sigma; D013482:Superoxide Dismutase; D000097605:Sigma-1 Receptor