title: Evaluation of insulin resistance and metabolic syndrome in a group of obese Czech children.
abstract: OBJECTIVE
  The study aimed to determine the incidence of metabolic syndrome (MS) in a group of Czech obese children, to evaluate the incidence of insulin resistance according to HOMA-IR in this group, and to consider the diagnostic value of HOMA-IR in early MS detection in obese children using the logistic regression models for analyzing the relations between HOMA IR and MS.
  
  
  METHODS
  Anthropometric and laboratory examinations were performed in a group of 274 obese children aged 10-17 years.
  
  
  RESULTS
  MS was established in 102 subjects (37%). The presence of insulin resistance according to HOMA-IR >3.16 was ascertained in 53% of the subjects. HOMA-IR limit was exceeded by 70% in the MS (+) group and by 43% in children in the MS (-) (p<0.0001) category.
  
  
  CONCLUSIONS
  The relatively high incidence of insulin resistance in obese children without MS questions the prevailing diagnostic criteria of, perhaps, falsely excluding some cases of, MS.
authors.forename: Dalibor
authors.initials: D
authors.lastname: Pastucha
authors.forename: Radka
authors.initials: R
authors.lastname: Filipčíková
authors.forename: Dagmar
authors.initials: D
authors.lastname: Horáková
authors.forename: Kateřina
authors.initials: K
authors.lastname: Azeem
authors.forename: Jana
authors.initials: J
authors.lastname: Malinčíková
authors.forename: Marek
authors.initials: M
authors.lastname: Kocvrlich
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008954:Models, Biological; D063766:Pediatric Obesity / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology*
chemical_list: D001786:Blood Glucose