title: Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo-controlled clinical trial.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the clinical and microbiological effect of systemic levofloxacin (LFX) as an adjunct to scaling and root planing (SRP) in patients with chronic periodontitis (CP).
  
  
  METHODS
  Sixty-five patients with CP were randomly divided into a test (n = 33, SRP and LFX 500 mg, once daily [o.d.]) and a control group (n = 32, SRP and placebo, o.d.). Plaque index (PI), gingival index (GI), percentage of sites with bleeding on probing (%BoP), probing depth (PD), and clinical attachment level (CAL) were recorded at baseline, 10 days, and 1-, 3-, and 6-month intervals. The percentage of sites positive for Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis, and Tannerella forsythia were recorded at baseline and at 3 and 6 months.
  
  
  RESULTS
  Patients receiving LFX showed statistically-significant improvements in mean PD and CAL. The intergroup difference in PI, GI, and%BoP was not significant at any interval. There was a reduction in the percentage of sites positive for periodontopathic bacteria over the duration of the study in both groups, and a statistically-significant reduction in the number of sites positive for A. actinomycetemcomitans in the LFX group (P < 0.001).
  
  
  CONCLUSIONS
  Levofloxacin was found to significantly improve the clinical and microbiological parameters in CP individuals.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Avani R
authors.initials: AR
authors.lastname: Pradeep
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Sonender P
authors.initials: SP
authors.lastname: Singh
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Santosh S
authors.initials: SS
authors.lastname: Martande
authors.affiliation: Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Savitha B
authors.initials: SB
authors.lastname: Naik
authors.affiliation: Department of Conservative Dentistry and Endodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: N
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Nitish
authors.initials: N
authors.lastname: Kalra
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India.
authors.forename: Deepak K
authors.initials: DK
authors.lastname: Suke
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D058491:Bacterial Load / Q000187:drug effects; D002710:Chlorhexidine / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000188:drug therapy* / Q000382:microbiology / Q000628:therapy; D003131:Combined Modality Therapy; D003773:Dental Plaque / Q000382:microbiology; D003774:Dental Plaque Index; D012534:Dental Scaling / Q000379:methods; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D064704:Levofloxacin / Q000627:therapeutic use*; D008297:Male; D009067:Mouthwashes / Q000627:therapeutic use; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy; D010919:Placebos; D016966:Porphyromonas gingivalis / Q000187:drug effects; D016745:Root Planing / Q000379:methods; D000070436:Tannerella forsythia / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D010919:Placebos; D064704:Levofloxacin; D002710:Chlorhexidine
keywords: antimicrobial; chronic periodontitis; clinical and microbiological effect; levofloxacin; scaling and root planing