title: Sirtuin 1 attenuates oxidative stress via upregulation of superoxide dismutase 2 and catalase in astrocytes.
abstract: Sirtuin 1 (SIRT1) exerts a neuroprotective effect on various neurologic diseases. Here we investigated the protective functions of SIRT1 in astrocytes, which are the most abundant cells in the central nervous system. Upregulation of SIRT1 suppressed the expression levels of pro-inflammatory cytokines and increased the expression levels of superoxide dismutase 2 and catalase. Inversely, inhibition of SIRT1 significantly increased the acetylation of forkhead box protein O4, decreased the expression levels of superoxide dismutase 2 and catalase, and increased the production of reactive oxygen species. Our data suggest that astrocytic SIRT1 may elicit neuroprotective effects through its anti-oxidative and anti-inflammatory functions.
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Yi
authors.initials: Y
authors.lastname: Cheng
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan. Electronic address: htake@riem.nagoya-u.ac.jp.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Takeuchi
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Sonobe
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Shijie
authors.initials: S
authors.lastname: Jin
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Horiuchi
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Bijay
authors.initials: B
authors.lastname: Parajuli
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Kawanokuchi
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mizuno
authors.affiliation: Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
authors.forename: Akio
authors.initials: A
authors.lastname: Suzumura
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000378:metabolism*; D002374:Catalase / Q000096:biosynthesis*; D002478:Cells, Cultured; D051379:Mice; D008810:Mice, Inbred C57BL; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D056564:Sirtuin 1 / Q000096:biosynthesis*; D013482:Superoxide Dismutase / Q000096:biosynthesis*; D015854:Up-Regulation / Q000502:physiology*; D000099156:Superoxide Dismutase 2
chemical_list: D002374:Catalase; D017382:Reactive Oxygen Species; D056564:Sirtuin 1; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C470545:Sirt1 protein, mouse
keywords: Astrocyte; Catalase; Forkhead box protein O4; Reactive oxygen species; Sirtuin 1; Superoxide dismutase 2