title: Human-induced pluripotent stem cell models of inherited cardiomyopathies.
abstract: OBJECTIVE
  This article provides an overview of the latest advances in in-vitro modeling of inherited cardiomyopathies using human-induced pluripotent stem cells (iPSCs).
  
  
  RESULTS
  Inherited cardiomyopathies have been recently modeled by generating iPSCs from patients harboring mutations in genes associated with the pathogenesis of hypertrophic cardiomyopathy, dilated cardiomyopathy, and arrhythmogenic right ventricular cardiomyopathy/dysplasia.
  
  
  CONCLUSIONS
  Patient-specific iPSCs and their differentiated cardiomyocytes (induced pluripotent stem cell-derived cardiomyocytes) now provide a novel model to study the underlying molecular mechanism of the pathogenesis of familial cardiomyopathies as well as for in-vitro drug screening and drug discovery.
authors.affiliation: aStanford Cardiovascular Institute bDivision of Cardiology, Department of Medicine cDepartment of Radiology dInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, USA.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Karakikes
authors.forename: Vittavat
authors.initials: V
authors.lastname: Termglinchan
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Wu
mesh_terms: D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D002311:Cardiomyopathy, Dilated / Q000151:congenital / Q000188:drug therapy / Q000473:pathology; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D055106:Genome-Wide Association Study; D006801:Humans; D066298:In Vitro Techniques / Q000379:methods / Q000639:trends; D057026:Induced Pluripotent Stem Cells / Q000187:drug effects / Q000473:pathology; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology