title: New insights into Alzheimer's disease amyloid inhibition: nanosized metallo-supramolecular complexes suppress aβ-induced biosynthesis of heme and iron uptake in PC12 cells.
abstract: Nanosized metallo-supramolecular compounds, [Ni2 L3 ](4+) and [Fe2 L3 ](4+) , can not only strongly inhibit Aβ aggregation but also reduce the peroxidase activity of Aβ-heme. Further studies demonstrate that through blocking the heme-binding site, these two compounds can suppress Aβ-induced biosynthesis of heme and iron uptake in PC12 cells. This work provides new insights into molecular mechanisms of Aβ inhibitors on Aβ-mediated neurotoxicity.
authors.affiliation: Laboratory of Chemical Biology, Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Chuanqi
authors.initials: C
authors.lastname: Zhao
authors.forename: Taicheng
authors.initials: T
authors.lastname: Duan
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D056831:Coordination Complexes / Q000737:chemistry / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis* / Q000737:chemistry; D007501:Iron / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D049329:Nanostructures / Q000737:chemistry*; D016716:PC12 Cells; D051381:Rats
chemical_list: D016229:Amyloid beta-Peptides; D056831:Coordination Complexes; D008024:Ligands; D006418:Heme; D007501:Iron
keywords: Aβ; heme synthesis; iron uptake; metallo-supramolecular complexes; peroxidase activity