title: Multiple wall in-folds sub-divide single segments during capillary regression in hyperoxic acute lung injury.
abstract: The present study provides further insight into the structural processes that remodel pulmonary capillaries in the injured adult lung. Early in hyperoxia acute lung injury (HALI), many sub-dividing segments are present throughout the capillary network before segment occlusion and loss predominate and capillary density decreases later in the period. A second segment sub-division triggered in regenerating capillaries after air breathing (post-HALI) demonstrates a similar mechanism of organization at a time of contrasting change in the capillary density. As we have previously reported, the process of segment sub-division includes in-folding of the endothelial-epithelial surface (alveolar-capillary membrane) to form inter-luminal structures (ILSs) and loops, with loop separation increasing segment number. Unexpectedly, the findings support remodeling of the capillary density by wall in-folding in acute lung injury, demonstrating a similar mechanism in capillary regression as well as in regeneration in the adult lung.
authors.affiliation: Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital , Boston, Massachusetts , USA and.
authors.forename: Rosemary C
authors.initials: RC
authors.lastname: Jones
authors.forename: Diane E
authors.initials: DE
authors.lastname: Capen
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology* / Q000473:pathology; D000818:Animals; D002196:Capillaries / Q000648:ultrastructure*; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000648:ultrastructure; D004847:Epithelial Cells / Q000648:ultrastructure; D018496:Hyperoxia / Q000150:complications*; D008168:Lung / Q000098:blood supply*; D008810:Mice, Inbred C57BL; D012038:Regeneration; D066253:Vascular Remodeling