title: Simulated games activity vs continuous running exercise: a novel comparison of the glycemic and metabolic responses in T1DM patients.
abstract: To compare the glycemic and metabolic responses to simulated intermittent games activity and continuous running exercise in type 1 diabetes. Nine patients (seven male, two female; 35 ± 4 years; HbA1c 8.1 ± 0.2%/65 ± 2 mmol/mol) treated on a basal-bolus regimen completed two main trials, a continuous treadmill run (CON) or an intermittent running protocol (INT). Patients arrived to the laboratory fasted at ∼ 08:00 h, replicating their usual pre-exercise meal and administering a 50% reduced dose of rapid-acting insulin before exercising. Blood glucose (BG), K(+) , Na(++) , pH, triglycerides, serum cortisol and NEFA were measured at baseline and for 60 min post-exercise. Interstitial glucose was measured for a further 23 h under free-living conditions. Following exercise, BG declined under both conditions but was less under INT (INT -1.1 ± 1.4 vs CON -5.3 ± 0.4 mmol/L, P = 0.037), meaning more patients experienced hypoglycemia (BG ≤ 3.5 mmol/L; CON n = 3 vs INT n = 2) but less hyperglycemia (BG ≥ 10.9 mmol/L; CON n = 0 vs INT n = 6) under CON. Blood lactate was significantly greater, and pH lower, with a temporal delay in K(+) under INT (P < 0.05). No conditional differences were observed in other measures during this time, or in interstitial glucose concentrations during the remaining 23 h after exercise. Simulated games activity carries a lower risk of early, but not late-onset hypoglycemia than continuous running exercise in type 1 diabetes.
authors.affiliation: Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Campbell
authors.forename: D J
authors.initials: DJ
authors.lastname: West
authors.forename: S C
authors.initials: SC
authors.lastname: Bain
authors.forename: M I C
authors.initials: MI
authors.lastname: Kingsley
authors.forename: P
authors.initials: P
authors.lastname: Foley
authors.forename: L
authors.initials: L
authors.lastname: Kilduff
authors.forename: D
authors.initials: D
authors.lastname: Turner
authors.forename: B
authors.initials: B
authors.lastname: Gray
authors.forename: J W
authors.initials: JW
authors.lastname: Stephens
authors.forename: R M
authors.initials: RM
authors.lastname: Bracken
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D005081:Exercise Therapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D000068957:Games, Recreational; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D007003:Hypoglycemia / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D019344:Lactic Acid / Q000097:blood; D008297:Male; D011897:Random Allocation; D012420:Running / Q000502:physiology*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D019344:Lactic Acid
keywords: T1DM; intermittent running; post-exercise hypoglycemia