title: Chemically orthogonal three-patch microparticles.
abstract: Compared to two-dimensional substrates, only a few methodologies exist for the spatially controlled decoration of three-dimensional objects, such as microparticles. Combining electrohydrodynamic co-jetting with synthetic polymer chemistry, we were able to create two- and three-patch microparticles displaying chemically orthogonal anchor groups on three distinct surface patches of the same particle. This approach takes advantage of a combination of novel chemically orthogonal polylactide-based polymers and their processing by electrohydrodynamic co-jetting to yield unprecedented multifunctional microparticles. Several micropatterned particles were fabricated displaying orthogonal click functionalities. Specifically, we demonstrate novel two- and three-patch particles. Multi-patch particles are highly sought after for their potential to present multiple distinct ligands in a directional manner. This work clearly establishes a viable route towards orthogonal reaction strategies on multivalent micropatterned particles.
authors.affiliation: Department of Biomedical Engineering, Chemical Engineering, Macromolecular Science and Engineering, Material Science and Engineering, University of Michigan, Ann Arbor, 48109 (USA) http://www.umich.edu/∼lahannj/index.htm; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen (Germany).
authors.forename: Sahar
authors.initials: S
authors.lastname: Rahmani
authors.forename: Sampa
authors.initials: S
authors.lastname: Saha
authors.forename: Hakan
authors.initials: H
authors.lastname: Durmaz
authors.forename: Alessandro
authors.initials: A
authors.lastname: Donini
authors.forename: Asish C
authors.initials: AC
authors.lastname: Misra
authors.forename: Jaewon
authors.initials: J
authors.lastname: Yoon
authors.forename: Joerg
authors.initials: J
authors.lastname: Lahann
mesh_terms: D057930:Click Chemistry / Q000379:methods; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D011091:Polyesters; C033616:poly(lactide)
keywords: click chemistry; electrohydrodynamic co-jetting; microparticles; orthogonal chemistry; surface chemistry