title: Association of Helicobacter pylori infection with coronary artery disease: is Helicobacter pylori a risk factor?
abstract: BACKGROUND
  Helicobacter pylori (HP) infection is the most common infection in the world and coronary artery disease (CAD) is probably associated with it. The aim of this prospective study was to evaluate the association between HP infection and CAD in suspected patients referred for coronary angiography. The coronary angiography was performed using Judkins method and patients were assigned to participate in CAD positive (>50% luminal diameter stenosis) and negative groups. The serum HP IgG antibody was checked.
  
  
  RESULTS
  Positive and negative CAD groups consisted of 62 and 58 patients, respectively. HP was more prevalent among CAD+ patients, and with increasing the number of coronary arteries with stenosis, the HP seropositivity increased so that 76.3% of patients with multiple vessel diseases (MVD) and 70% of patients with single vessel diseases (SVD) were HP seropositive versus 50% in control group (P = 0.006). Positive CAD was significantly associated with HDL level (P = 0.01) and ESR level (P = 0.006). Also, CAD+ patients had higher CRP levels than controls and it was statistically different between SVD group and controls (P < 0.05).
  
  
  CONCLUSIONS
  HP infection is more prevalent in CAD positive patients and, in case of proving causal relationship, it can be considered as a reversible risk factor for CAD.
authors.affiliation: Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Jamshid
authors.identifier: 0000-0002-9063-2639
authors.initials: J
authors.lastname: Vafaeimanesh
authors.affiliation: Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Seyyed Fakhroldin
authors.initials: SF
authors.lastname: Hejazi
authors.affiliation: Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Damanpak
authors.affiliation: Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Vahedian
authors.affiliation: Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran.
authors.forename: Mohammadamin
authors.initials: M
authors.lastname: Sattari
authors.affiliation: Golestan Research Center of Gastroenterology and Hepatology (GRCGH), Golestan University of Medical Sciences (GOUMS), 10th Azar, 5 Azar Boulevard, Gorgan, Golestan Province, Iran.
authors.forename: Mohammadreza
authors.identifier: 0000-0002-5264-6706
authors.initials: M
authors.lastname: Seyyedmajidi
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D008075:Lipoproteins, HDL; D002097:C-Reactive Protein