title: Working memory training with tDCS improves behavioral and neurophysiological symptoms in pilot group with post-traumatic stress disorder (PTSD) and with poor working memory.
abstract: This pilot study investigated the feasibility of treating people suffering from both post-traumatic stress disorder (PTSD) and poor working memory by employing a combination of computerized working memory training and transcranial direct current stimulation (tDCS). After treatment, all four participants showed clinically significant improvements on a range of cognitive and emotional performance measures. Moreover, these improvements were accompanied by theoretically significant neurophysiological changes between pre- and post-treatment electroencephalographic (EEG) recordings. Specifically, the P3a component of participants' event related potentials (ERP) in response to novelty stimuli, characteristically abnormal in this clinical population, shifted significantly toward database norms. So, participants' initially slow alpha peak frequency (APF), theorized to underlie impaired cognitive processing abilities, also increased in both frequency and amplitude as a result of treatment. On the basis of these promising results, more extensive controlled studies are warranted.
authors.affiliation: a School of Medicine , University of Sydney , Sydney , Australia.
authors.forename: Nerida
authors.initials: N
authors.lastname: Saunders
authors.forename: Russell
authors.initials: R
authors.lastname: Downham
authors.forename: Bulent
authors.initials: B
authors.lastname: Turman
authors.forename: Juri
authors.initials: J
authors.lastname: Kropotov
authors.forename: Richard
authors.initials: R
authors.lastname: Clark
authors.forename: Rustam
authors.initials: R
authors.lastname: Yumash
authors.forename: Arielle
authors.initials: A
authors.lastname: Szatmary
mesh_terms: D000368:Aged; D001931:Brain Mapping; D003657:Decision Making; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D008569:Memory Disorders / Q000628:therapy*; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011930:Reaction Time; D013313:Stress Disorders, Post-Traumatic / Q000628:therapy*; D065908:Transcranial Direct Current Stimulation / Q000379:methods*
keywords: P3a; neuromodulation; post-traumatic stress disorder (PTSD); transcranial direct current stimulation (tDCS); working memory training