title: Synthesis of taurine-containing peptides, sulfonopeptides, and N- and O-conjugates.
abstract: Taurine-containing water-soluble peptidomimetics were designed and synthesized. N-terminal taurine acylations allowed synthesis of a number of taurine-containing peptides. N-protection of taurine with Cbz and SO2-activation with benzotriazole followed by coupling with various amino esters, dipeptides and nucleophiles provided taurine N- and O-conjugates and sulfonopeptides.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida , Gainesville, Florida 32611-7200, United States.
authors.forename: Peter
authors.initials: P
authors.lastname: Vertesaljai
authors.forename: Suvendu
authors.initials: S
authors.lastname: Biswas
authors.forename: Iryna
authors.initials: I
authors.lastname: Lebedyeva
authors.forename: Evan
authors.initials: E
authors.lastname: Broggi
authors.forename: Abdullah M
authors.initials: AM
authors.lastname: Asiri
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
mesh_terms: D009584:Nitrogen / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D057786:Peptidomimetics / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013654:Taurine / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry*
chemical_list: D010455:Peptides; D057786:Peptidomimetics; D013438:Sulfhydryl Compounds; D014230:Triazoles; D013654:Taurine; C012771:benzotriazole; D009584:Nitrogen; D010100:Oxygen