title: A coumarin-based fluorescent probe for recognition of Cu(2+) and fast detection of histidine in hard-to-transfect cells by a sensing ensemble approach.
abstract: A coumarin-based fluorescent chemosensor CAQA has been synthesized. It can selectively and sensitively recognize Cu(2+) in aqueous acetonitrile solutions. Using the Cu-containing complex CAQA-Cu(2+) as a sensing ensemble, the device demonstrates highly selective recognition of His/biothiols and was applied in fluorescence imaging of histidine in hard-to-transfect living cells.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, P. R. China. whchan@hkbu.edu.hk.
authors.forename: Qi-Hua
authors.initials: QH
authors.lastname: You
authors.forename: Albert Wai-Ming
authors.initials: AW
authors.lastname: Lee
authors.forename: Wing-Hong
authors.initials: WH
authors.lastname: Chan
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zhu
authors.forename: Ken Cham-Fai
authors.initials: KC
authors.lastname: Leung
mesh_terms: D045744:Cell Line, Tumor; D003300:Copper / Q000032:analysis*; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D006639:Histidine / Q000032:analysis*; D006801:Humans; D015394:Molecular Structure; D014162:Transfection
chemical_list: D003374:Coumarins; D005456:Fluorescent Dyes; D006639:Histidine; D003300:Copper; C030123:coumarin