title: Ultrafast Z-Spectroscopy for129Xe NMR-Based Sensors.
abstract: When working with hyperpolarized species, it is often difficult to maintain a stable level of magnetization over consecutive experiments, which renders their detection at the trace level cumbersome, even when combined with chemical exchange saturation transfer (CEST). We report herein the use of ultra-fast Z-spectroscopy as a powerful means to detect low concentrations of129Xe NMR-based sensors and to measure the in-out xenon exchange. Modifications of the original sequence enable a multiplexed detection of several sensors, as well as the extraction of the exchange buildup rate constant in a single-shot fashion.
authors.affiliation: CEA Saclay, IRAMIS, SIS2M, UMR CEA/CNRS 3299, Laboratoire Structure et Dynamique par Résonance Magnétique, 91191 Gif sur Yvette, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Boutin
authors.affiliation: CEA Saclay, IRAMIS, SIS2M, UMR CEA/CNRS 3299, Laboratoire Structure et Dynamique par Résonance Magnétique, 91191 Gif sur Yvette, France.
authors.forename: Estelle
authors.initials: E
authors.lastname: Léonce
authors.affiliation: Laboratoire de Chimie, CNRS, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Brotin
authors.affiliation: Chemistry Department, New York University, 100 Washington Square East, New York, NY 10003, USA.
authors.forename: Alexej
authors.initials: A
authors.lastname: Jerschow
authors.affiliation: CEA Saclay, IRAMIS, SIS2M, UMR CEA/CNRS 3299, Laboratoire Structure et Dynamique par Résonance Magnétique, 91191 Gif sur Yvette, France.
authors.forename: Patrick
authors.initials: P
authors.lastname: Berthault
keywords: Biosensors; Exchange; Hyperpolarization; Magnetic Resonance; Sensitivity