title: New La(III) complex immobilized on 3-aminopropyl-functionalized silica as an efficient and reusable catalyst for hydrolysis of phosphate ester bonds.
abstract: Described herein is the synthesis, structure, and monoesterase and diesterase activities of a new mononuclear [La(III)(L(1))(NO3)2] (1) complex (H2L(1) = 2-bis[{(2-pyridylmethyl)-aminomethyl}-6-[N-(2-pyridylmethyl) aminomethyl)])-4-methyl-6-formylphenol) in the hydrolysis of 2,4-bis(dinitrophenyl)phosphate (2,4-BDNPP). When covalently linked to 3-aminopropyl-functionalized silica, 1 undergoes disproportionation to form a dinuclear species (APS-1), whose catalytic efficiency is increased when compared to the homogeneous reaction due to second coordination sphere effects which increase the substrate to complex association constant. The anchored catalyst APS-1 can be recovered and reused for subsequent hydrolysis reactions (five times) with only a slight loss in activity. In the presence of DNA, we suggest that 1 is also converted into the dinuclear active species as observed with APS-1, and both were shown to be efficient in DNA cleavage.
authors.affiliation: Departamento de Química, Laboratório de Bioinorgânica e Cristalografia (LABINC), Universidade Federal de Santa Catarina , SC, 88040-900 Florianópolis, Brazil.
authors.forename: Alfredo A
authors.initials: AA
authors.lastname: Muxel
authors.forename: Ademir
authors.initials: A
authors.lastname: Neves
authors.forename: Maryene A
authors.initials: MA
authors.lastname: Camargo
authors.forename: Adailton J
authors.initials: AJ
authors.lastname: Bortoluzzi
authors.forename: Bruno
authors.initials: B
authors.lastname: Szpoganicz
authors.forename: Eduardo E
authors.initials: EE
authors.lastname: Castellano
authors.forename: Nathalia
authors.initials: N
authors.lastname: Castilho
authors.forename: Tiago
authors.initials: T
authors.lastname: Bortolotto
authors.forename: Hernán
authors.initials: H
authors.lastname: Terenzi
mesh_terms: D002384:Catalysis; D004952:Esters; D006868:Hydrolysis; D007811:Lanthanum / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D004952:Esters; D010710:Phosphates; D007811:Lanthanum; D012822:Silicon Dioxide