title: Single institution retrospective review of perioperative chemotherapy in adult and adolescent patients with operable osteosarcoma.
abstract: OBJECTIVE
  Perioperative chemotherapy has improved the prognosis for patients with operable osteosarcoma. The literature is conflicting about which regimen is optimal. The aim of this study was to evaluate the survival outcomes of two cohorts of patients with operable osteosarcoma treated with different perioperative chemotherapy regimens.
  
  
  METHODS
  This was a retrospective review of patients diagnosed with operable osteosarcoma treated at the Princess Alexandra Hospital from 1986 to 2009. The standard perioperative chemotherapy regimen changed from the modified T10 Rosen protocol to cisplatin/doxorubicin in 1997. Using the Kaplan-Meier method, overall survival (OS) and disease-free survival (DFS) curves were generated for the cisplatin/doxorubicin and the modified T10 Rosen cohorts.
  
  
  RESULTS
  Seventy-one patients were identified of whom 63 had potentially curable disease. Of these, 24 received the modified T10 Rosen regimen and 39 received cisplatin/doxorubicin. There was a non-significant trend toward better OS and DFS in the patients who received the modified T10 Rosen protocol.
  
  
  CONCLUSIONS
  The trend toward poorer survival in the cisplatin/doxorubicin cohort, in combination with current evidence, has prompted our institution to change its practice.
authors.affiliation: Division of Cancer Services, Princess Alexandra Hospital, Queensland, Australia.
authors.forename: Aaron R
authors.initials: AR
authors.lastname: Hansen
authors.affiliation: Cancer Care Services, The Royal Brisbane and Women's Hospital, Queensland, Australia.
authors.forename: Brett Gm
authors.initials: BG
authors.lastname: Hughes
authors.affiliation: Queensland Clinical Trials and Biostatistics Centre, School of Population Health, The University of Queensland, Princess Alexandra Hospital, Queensland, Australia.
authors.forename: Sanjoy
authors.initials: S
authors.lastname: Paul
authors.affiliation: Department of Orthopaedics, Princess Alexandra Hospital, Queensland, Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Steadman
authors.affiliation: Department of Orthopaedics, Princess Alexandra Hospital, Queensland, Australia.
authors.forename: Scott
authors.initials: S
authors.lastname: Sommerville
authors.affiliation: Department of Orthopaedics, Princess Alexandra Hospital, Queensland, Australia.
authors.forename: Ian C
authors.initials: IC
authors.lastname: Dickinson
authors.affiliation: Division of Cancer Services, Princess Alexandra Hospital, Queensland, Australia.
authors.forename: Euan T
authors.initials: ET
authors.lastname: Walpole
authors.affiliation: Division of Cancer Services, Princess Alexandra Hospital, Queensland, Australia.
authors.forename: Damien B
authors.initials: DB
authors.lastname: Thomson
authors.affiliation: Division of Cancer Services, Princess Alexandra Hospital, Queensland, Australia.|University of Queensland School of Medicine, Brisbane, Queensland, Australia.
authors.forename: Helen G
authors.initials: HG
authors.lastname: Mar Fan
authors.affiliation: Division of Cancer Services, Princess Alexandra Hospital, Queensland, Australia.
authors.forename: Warren L
authors.initials: WL
authors.lastname: Joubert
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000188:drug therapy* / Q000601:surgery*; D019990:Perioperative Care / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult
keywords: methotrexate; osteosarcoma; perioperative chemotherapy