title: Development of a Suzuki cross-coupling reaction between 2-azidoarylboronic pinacolate esters and vinyl triflates to enable the synthesis of [2,3]-fused indole heterocycles.
abstract: The scope and limitations of a Suzuki reaction between 2-azidoarylboronic acid pinacolate esters and vinyl triflates are reported. This cross-coupling reaction enables the regioselective synthesis of indoles after a subsequent Rh(II)2-catalyzed sp(2)-C-H bond amination reaction.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago , 845 West Taylor Street, Chicago, Illinois 60607, United States.
authors.forename: Navendu
authors.initials: N
authors.lastname: Jana
authors.forename: Quyen
authors.initials: Q
authors.lastname: Nguyen
authors.forename: Tom G
authors.initials: TG
authors.lastname: Driver
mesh_terms: D000586:Amination; D001897:Boronic Acids / Q000737:chemistry; D002384:Catalysis; D004952:Esters; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D001897:Boronic Acids; D004952:Esters; D006571:Heterocyclic Compounds; D007211:Indoles; D008698:Mesylates; D014753:Vinyl Compounds; C437735:vinyl triflate; D012428:Ruthenium; C030374:indole