title: Diabetes and cancer.
abstract: Diabetes is a worldwide health problem that has been increasingly associated with various types of cancers. Epidemiologic studies have shown an increased risk of cancer as well as a higher mortality rate in patients with type 2 diabetes (T2D). The biologic mechanisms driving the link between T2D and cancer are not well understood. In this review, various proposed mechanisms are addressed to explain the relationship between T2D and cancer. Understanding the precise mechanisms that link T2D, obesity, and the metabolic syndrome with cancer will aid in developing treatments that will reduce mortality in individuals with T2D and cancer.
authors.affiliation: Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1055, New York, NY 10029, USA.
authors.forename: Zara
authors.initials: Z
authors.lastname: Zelenko
authors.affiliation: Division of Endocrinology, Diabetes and Bone Diseases, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1055, New York, NY 10029, USA. Electronic address: emily.gallagher@mssm.edu.
authors.forename: Emily Jane
authors.initials: EJ
authors.lastname: Gallagher
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000276:immunology / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000276:immunology / Q000378:metabolism
keywords: Cancer; Diabetes mellitus; Hyperglycemia; Hyperinsulinemia; Inflammation; Metabolic syndrome; Obesity