title: Association of sequence polymorphism in the mitochondrial D-loop with chronic kidney disease.
abstract: BACKGROUND
  The mitochondrial displacement loop (D-loop) is known to accumulate mutations and single nucleotide polymorphisms (SNPs) at a higher frequency than other regions of mitochondrial DNA (mtDNA).
  
  
  METHODS
  This is a case-control study. We sequenced SNPs in the D-loop of mtDNA and investigated their association with the risk of chronic kidney disease (CKD).
  
  
  RESULTS
  A total of 144 SNPs referring to the positions of the Revised Cambridge Reference Sequence (rCRS) for mitochondrial genome were identified in a case-control study. The minor alleles of nucleotides 73G, 146C, 150T, 194T, 195C and 310C were associated with an increased risk for CKD patients.
  
  
  CONCLUSIONS
  Analysis of genetic polymorphisms in the mitochondrial D-loop can help identify the people who are at a high risk of developing chronic kidney disease. These SNPs can be considered as potential predictors for CKD.
authors.affiliation: Department of Nephrology, The Fourth Hospital of Hebei Medical University , Shijiazhuang , P.R. China and.
authors.forename: Yaling
authors.initials: Y
authors.lastname: Bai
authors.forename: Zhanjun
authors.initials: Z
authors.lastname: Guo
authors.forename: Jinsheng
authors.initials: J
authors.lastname: Xu
authors.forename: Junxia
authors.initials: J
authors.lastname: Zhang
authors.forename: Liwen
authors.initials: L
authors.lastname: Cui
authors.forename: Huiran
authors.initials: H
authors.lastname: Zhang
authors.forename: Shenglei
authors.initials: S
authors.lastname: Zhang
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Ai
mesh_terms: D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000737:chemistry*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D051436:Renal Insufficiency, Chronic / Q000235:genetics*
chemical_list: D004272:DNA, Mitochondrial
keywords: Chronic kidney disease; D-loop; SNP; mtDNA