title: Musical chairs during mitophagy.
abstract: Mitophagy, or the autophagic degradation of mitochondria, is thought to be important in mitochondrial quality control, and hence in cellular physiology. Defects in mitophagy correlate with late onset pathologies and aging. Here, we discuss recent results that shed light on the interrelationship between mitophagy and mitochondrial dynamics, based on proteomic analyses of protein dynamics in wild-type and mutant cells. These studies show that different mitochondrial matrix proteins undergo mitophagy at different rates, and that the rate differences are affected by mitochondrial dynamics. These results are consistent with models in which phase separation within the mitochondrial matrix leads to unequal segregation of proteins during mitochondrial fission. Repeated fusion and fission cycles may thus lead to "distillation" of components that are destined for degradation.
authors.affiliation: Department of Dermatology; University Freiburg Medical Center; ZBSA Center for Biological Systems Analysis; Freiburg Institute for Advanced Studies (FRIAS); BIOSS Centre for Biological Signalling Studies; University of Freiburg; Habsburgerstr, Freiburg Germany.
authors.forename: Joern
authors.initials: J
authors.lastname: Dengjel
authors.affiliation: Institute of Biochemistry, Food Science and Nutrition; R.H. Smith Faculty of Agriculture, Food and Environment; Hebrew University of Jerusalem; Rehovot, Israel.
authors.forename: Hagai
authors.initials: H
authors.lastname: Abeliovich
mesh_terms: D000818:Animals; D001343:Autophagy / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000378:metabolism*; D063306:Mitophagy / Q000502:physiology*; D040901:Proteomics / Q000379:methods; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; D029701:Saccharomyces cerevisiae Proteins
keywords: S. cerevisiae; autophagy; mitochondrial dynamics; mitophagy; vacuole