title: Microwave-assisted preparation of azachalcones and their N-alkyl derivatives with antimicrobial activities.
abstract: Two new azachalcones were prepared by both Claisen-Schmidt condensation and a simple environmentally trendy microwave-assisted method. Ten new N-alkyl (C6,8,10,12,14)-substituted azachalconium bromides (3a-e, 4a-e) were prepared from compounds 1 and 2 with corresponding alkyl halides. The antimicrobial activities of all the compounds were tested against Enterococcus faecalis, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus micro-organisms.
authors.affiliation: a Department of Chemistry, Faculty of Art and Science , Recep Tayyip Erdog˘an University , 53100 Rize , Turkey.
authors.forename: Asu
authors.initials: A
authors.lastname: Usta
authors.forename: Elif
authors.initials: E
authors.lastname: Öztürk
authors.forename: Fatih Ş
authors.initials: FŞ
authors.lastname: Beriş
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D047188:Chalcones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008872:Microwaves; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D015007:Yersinia / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001372:Aza Compounds; D047188:Chalcones