title: Nanogel-based antigen-delivery system for nasal vaccines.
abstract: Nasal vaccination is considered a potent and practical immunization route for the induction of effective immunity to infectious diseases. Successful nasal vaccines require efficient delivery to, and retention of antigens within, nasal mucosa, including both the inductive (e.g., nasopharynx-associated lymphoid tissues) and effector (e.g., turbinate covered with single-layer epithelium) tissues, where antigen-specific immune responses are initiated and executed, respectively. We developed an approach towards successful nasal vaccination by using self-assembled nano-sized hydrogel particles, known as nanogels, which are composed of a cationic type of cholesteryl group-bearing pullulan. Here, we review the merging of nanotechnological and immunological concepts leading to the development of next-generation nasal vaccines, and demonstrate the applicability of novel nanogel-based vaccine for the prevention of infectious diseases.
authors.affiliation: a Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science , University of Tokyo , Tokyo , Japan.
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Yuki
authors.forename: Tomonori
authors.initials: T
authors.lastname: Nochi
authors.forename: Il Gyu
authors.initials: IG
authors.lastname: Kong
authors.forename: Haruko
authors.initials: H
authors.lastname: Takahashi
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Sawada
authors.forename: Kazunari
authors.initials: K
authors.lastname: Akiyoshi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kiyono
mesh_terms: D000281:Administration, Intranasal; D000941:Antigens / Q000008:administration & dosage* / Q000737:chemistry / Q000276:immunology; D018014:Gene Transfer Techniques; D006801:Humans; D018832:Molecular Chaperones / Q000008:administration & dosage / Q000737:chemistry; D000080385:Nanogels; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000737:chemistry; D011094:Polyethyleneimine / Q000008:administration & dosage* / Q000737:chemistry; D014612:Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000941:Antigens; D018832:Molecular Chaperones; D000080385:Nanogels; D014612:Vaccines; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine