title: [Psoriasis: physiopathology and immunogenetics].
abstract: Psoriasis is a multifactorial disease that involves genetic, immunological and environmental factors. During the last decade, several studies by genome scan on families or cases/controls helped to highlight more than ten loci "PSORS" located on different chromosomes and containing several candidate genes. Psoriasis appears as a genetic disease that follows the mixed model with the involvement of a major gene (PSORS1) and a set of minor genes with a variable penetrance depending on the locus. Genetic data have focused on the involvement of the immune system in the pathogenesis of psoriasis. It is now accepted that psoriasis is an immunological disease involving the response profiles TH1 and TH17. Much remains to be done to better elucidate the mechanisms involved in the genesis of psoriatic lesions to find new therapeutic targets.
authors.affiliation: Laboratoire de génétique, d'immunologie et de pathologies humaines, faculté des sciences de Tunis, université El Manar II, 2092 Tunis, Tunisie. Electronic address: myriambensaid@yahoo.fr.
authors.forename: M
authors.initials: M
authors.lastname: Ammar
authors.affiliation: Laboratoire de génétique, d'immunologie et de pathologies humaines, faculté des sciences de Tunis, université El Manar II, 2092 Tunis, Tunisie.
authors.forename: C
authors.initials: C
authors.lastname: Souissi-Bouchlaka
authors.affiliation: Laboratoire de génétique, d'immunologie et de pathologies humaines, faculté des sciences de Tunis, université El Manar II, 2092 Tunis, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Gati
authors.affiliation: Service de dermatologie, hôpital la Rabta, 1007 Tunis, Tunisie.
authors.forename: I
authors.initials: I
authors.lastname: Zaraa
authors.affiliation: Laboratoire de génétique, d'immunologie et de pathologies humaines, faculté des sciences de Tunis, université El Manar II, 2092 Tunis, Tunisie.
authors.forename: R
authors.initials: R
authors.lastname: Bouhaha
authors.affiliation: Laboratoire de génétique, d'immunologie et de pathologies humaines, faculté des sciences de Tunis, université El Manar II, 2092 Tunis, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Kouidhi
authors.affiliation: Laboratoire de génétique, d'immunologie et de pathologies humaines, faculté des sciences de Tunis, université El Manar II, 2092 Tunis, Tunisie.
authors.forename: A
authors.initials: A
authors.lastname: Ben Ammar-Gaied
authors.affiliation: Service de dermatologie, hôpital militaire de Tunis, rue Raouth Ibnou Hatem, Tunis, Tunisie.
authors.forename: N
authors.initials: N
authors.lastname: Doss
authors.affiliation: Service de dermatologie, hôpital la Rabta, 1007 Tunis, Tunisie.
authors.forename: M
authors.initials: M
authors.lastname: Mokni
authors.affiliation: Laboratoire de génétique, d'immunologie et de pathologies humaines, faculté des sciences de Tunis, université El Manar II, 2092 Tunis, Tunisie.
authors.forename: R
authors.initials: R
authors.lastname: Marrakchi
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002874:Chromosome Mapping; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D004195:Disease Models, Animal; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D019683:Penetrance; D011565:Psoriasis / Q000209:etiology* / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins
keywords: Genetic; Génétique; Immunopathologie; Immunopathology; PSORS1; Physiopathologie; Physiopathology; Psoriasis; TH17