title: A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions.
abstract: Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.
authors.affiliation: Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Comprehensive Cancer Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California, USA.
authors.forename: Robin G
authors.initials: RG
authors.lastname: Lerner
authors.affiliation: Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Comprehensive Cancer Center, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, California, USA.
authors.forename: Claudia
authors.initials: C
authors.lastname: Petritsch
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D008938:Mitosis; D014411:Neoplastic Stem Cells / Q000502:physiology*; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000502:physiology*
chemical_list: C542542:MIRN146 microRNA, human; D035683:MicroRNAs; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors