title: Evaluation of neuropathy during intensive vincristine chemotherapy for non-Hodgkin's lymphoma and Acute Lymphoblastic Leukemia.
abstract: BACKGROUND
  Vincristine (VCR), is a chemotherapy drug, useful in the treatment of leukemia, lymphoma and solid tumor and it is a potent neurotoxin and sensory neuropathy drug which a common behavioral toxicity of this drug. Neuropathy is common squeal of intensive chemotherapy protocols that contain vincristine and corticosteroids.
  
  
  METHODS
  This study was a retrospective and descriptive study of neuropathy during in chemotherapy program with vincristine for patients with non-Hodgkin's lymphoma (NHL) and Acute Lymphoblastic Leukemia (ALL). Data was analyzed by spss Version16 software.
  
  
  RESULTS
  From total of 51 cases, 23 patients had vincristine neuropathy (45%). Patients with visceral neuropathy have shown ileus, constipation in 13 patients (25%), occasionally severe diarrhea 11 (21%), mild diarrhea 7 (13.7%) and transient diarrhea in 16 patients (31%). Motor neuropathy were found in one patient with Bell, s palsy (1.9%) and one patient with Hoarseness. 12 patients (23.5%) had some type of complication together with sensory peripheral neuropathy.
  
  
  CONCLUSIONS
  Almost half of patients with vincristin chemotherapy had neuropathy and the mean age of patients with neuropathy was 12.3 years.
authors.affiliation: Radiation Oncologist, Oncology Department, Dezfol University of Medical Sciences. Dezfol. Iran. ; HematoOncologist, Oncology department, Al-Bairouni University Hospital, Medical faculty, Damascus University, Damascus, Syria.
authors.forename: M
authors.initials: M
authors.lastname: Dorchin
authors.affiliation: Health Policy Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: R
authors.initials: R
authors.lastname: Masoumi Dehshiri
authors.affiliation: HematoOncologist, Oncology department, Al-Bairouni University Hospital, Medical faculty, Damascus University, Damascus, Syria.
authors.forename: S
authors.initials: S
authors.lastname: Soleiman
authors.affiliation: HematoOncologist, Oncology department, Al-Bairouni University Hospital, Medical faculty, Damascus University, Damascus, Syria.
authors.forename: M
authors.initials: M
authors.lastname: Manashi
keywords: Acute Lymphoblastic Leukemia; Neuropathy; Vincristine; non-Hodgkin's lymphoma