title: Cellular immune controls over Epstein-Barr virus infection: new lessons from the clinic and the laboratory.
abstract: Epstein-Barr virus (EBV), a human herpesvirus with potent B cell growth transforming ability, induces multiple cellular immune responses in the infected host. How these host responses work together to prevent virus pathogenicity, and how immune imbalance predisposes to disease, remain poorly understood. Here, we describe three ongoing lines of enquiry that are shedding new light on these issues. These focus on: (i) patients with infectious mononucleosis or its fatal equivalent, X-linked lymphoproliferative disease; (ii) EBV infection in a range of new, genetically defined, primary immune deficiency states; and (iii) experimental infection in two complementary animal models, the rhesus macaque and the human haemopoietic stem cell reconstituted mouse.
authors.affiliation: School of Cancer Sciences and Centre for Human Virology, University of Birmingham, Birmingham, UK. Electronic address: A.B.Rickinson@bham.ac.uk.
authors.forename: Alan B
authors.initials: AB
authors.lastname: Rickinson
authors.affiliation: School of Cancer Sciences and Centre for Human Virology, University of Birmingham, Birmingham, UK.
authors.forename: Heather M
authors.initials: HM
authors.lastname: Long
authors.affiliation: Centenary Institute, University of Sydney, Sydney, Australia.
authors.forename: Umaimainthan
authors.initials: U
authors.lastname: Palendira
authors.affiliation: Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zurich, Switzerland.
authors.forename: Christian
authors.initials: C
authors.lastname: Münz
authors.affiliation: School of Cancer Sciences and Centre for Human Virology, University of Birmingham, Birmingham, UK.
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hislop
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D020031:Epstein-Barr Virus Infections / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*
keywords: Epstein–Barr virus; NK cells; T cells; animal models; immunodeficiency