title: Inflammatory myopathy associated with statins: report of three cases.
abstract: Statins are well-established lipid-lowering drugs that reduce morbidity and mortality due to cardiovascular disease and cause adverse effects relatively rarely. It is still unclear whether statins are capable of inducing an immune-mediated response directed against skeletal muscle. Here, we present the cases of three patients who developed inflammatory myopathy in the course of statin treatment. Moreover, multiple mitochondrial DNA deletions were found in two of them. The ability of statins to induce an immune-mediated response and their interactions with mitochondrial metabolism pathways are discussed.
authors.affiliation: Department of Pathology and Molecular Medicine, Second Medical Faculty and University Hospital Motol, Charles University , Prague 5 , Czech Republic.
authors.forename: Klara
authors.initials: K
authors.lastname: Kuncova
authors.forename: Marie
authors.initials: M
authors.lastname: Sedlackova
authors.forename: Jiri
authors.initials: J
authors.lastname: Vencovsky
authors.forename: Herman
authors.initials: H
authors.lastname: Mann
authors.forename: Michal
authors.initials: M
authors.lastname: Tomcik
authors.forename: Laszlo
authors.initials: L
authors.lastname: Wenchich
authors.forename: Josef
authors.initials: J
authors.lastname: Zamecnik
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000473:pathology; D009220:Myositis / Q000139:chemically induced* / Q000473:pathology
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors