title: The evolution of mammalian hibernation: lessons from comparative acid-base physiology.
abstract: The conquest of land has endowed air-breathers with the capability to utilize ventilation not only to acquire oxygen but also to control blood and intracellular acid-base state. Hypercapnic acidosis (resulting from ventilatory control and/or behavioral choice), thus, has become a universal component of hypometabolic states in air-breathers, with inhibitory and/or protective roles. Here, special emphasis is placed on the understanding of alterations of acid-base state associated with changes in temperature. Hypercapnic acidosis in connection with hypometabolism has been found in a variety of air-breathing clades, from snails to mammals through lungfish, amphibians, and reptiles. The discovery of the plesiomorphic character of mammalian hibernation has made the transfer to hibernation biology of the experience gained in the application of hypercapnic acidosis (the so-called "pH-stat" procedure) relevant to acid-base control in clinical artificial hypothermia. This paves the way for mutual benefits from such reciprocal exchange of information between hibernation biology and clinical applications.
authors.affiliation: Institute for Cellular and Integrative Neurosciences, CNRS and University of Strasbourg, 5 Rue Blaise Pascal, 67084 Strasbourg Cedex, France malan@inci-cnrs.unistra.fr.
authors.forename: André
authors.initials: A
authors.lastname: Malan
mesh_terms: D000136:Acid-Base Equilibrium / Q000235:genetics / Q000502:physiology*; D000138:Acidosis; D000818:Animals; D005075:Biological Evolution; D006605:Hibernation / Q000235:genetics / Q000502:physiology*; D008322:Mammals / Q000235:genetics / Q000502:physiology*