title: Comparison of cervical cell morphology using two different cytology techniques for early detection of pre-cancerous lesions.
abstract: Cervical cancer is an issue of foremost importance globally, specifically affecting the developing nations. Significant advances have taken place with regard to diagnosis of cervical cancer, especially with screening. Appropriate screening measures can thus reduce the incidence of cervical cancer. The most desirable screening technique should be less invasive, easy to perform, cost-effective and cover a wide range of diagnostic icons. Manual liquid based cytology (MLBC) can be considered as one of the suitable technique for screening with the above-mentioned benefits. The aim of the current study was to compare two cervical screening techniques on the basis of different morphological parameters and staining parameters by using modified acetic acid Pap staining to see the possibility of reducing time economy involved in conventional Pap staining (CPS). The study was conducted on a total 88 cases and all were analyzed with both MLBC and CPS. Forty eight cases that were regarded as satisfactory on the basis of Bethesda system by both methods were further recruited for investigation. Their morphological parameters and staining quality were compared and scored according to a scoring system defined in the study. Quality indices was calculated for both staining procedures and smear techniques.
authors.affiliation: Department of Pathology, IBMS, Khyber Medical University, Peshawar, Pakistan E-mail : najlayousaf@gmail.com.
authors.forename: Najla Yussuf
authors.initials: NY
authors.lastname: Moosa
authors.forename: Nuzhat
authors.initials: N
authors.lastname: Khattak
authors.forename: Muhammad Irfan
authors.initials: MI
authors.lastname: Alam
authors.forename: Alam
authors.initials: A
authors.lastname: Sher
authors.forename: Walayat
authors.initials: W
authors.lastname: Shah
authors.forename: Shumaila
authors.initials: S
authors.lastname: Mobashar
authors.forename: Muhammad Imran
authors.initials: MI
authors.lastname: Alam
authors.forename: Asima
authors.initials: A
authors.lastname: Javid
mesh_terms: D002584:Cervix Uteri / Q000473:pathology*; D003584:Cytological Techniques / Q000379:methods*; D055088:Early Detection of Cancer; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D065006:Papanicolaou Test; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000517:prevention & control; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000517:prevention & control; D014626:Vaginal Smears