title: Considerations in perioperative assessment of valproic acid coagulopathy.
abstract: Valproic acid (VPA) is one of the widely prescribed antiepileptic drugs in children with multiple indications. VPA-induced coagulopathy may occur and constitute a pharmacological and practical challenge affecting pre-operative evaluation and management of patients receiving VPA therapy. This review summarizes the different studies documenting the incidence, severity and available recommendations related to this adverse effect.
authors.affiliation: Department of Anesthesiology, Children's National Medical Center, The George Washington University Medical Center, NW Washington, DC, USA.
authors.forename: Claude
authors.initials: C
authors.lastname: Abdallah
keywords: Adverse effects; anesthesia; coagulation disorders; perioperative care; valproic acid