title: One-Pot Asymmetric Nitro-Mannich/Hydroamination Cascades for the Synthesis of Pyrrolidine Derivatives: Combining Organocatalysis and Gold Catalysis.
abstract: The highly enantioselective preparation of trisubstituted pyrrolidine derivatives employing a one-pot nitro-Mannich/hydroamination cascade is reported. This cascade approach utilizes an asymmetric bifunctional organocatalytic nitro-Mannich reaction followed by a gold-catalyzed allene hydroamination reaction. The products are afforded in good yields and excellent diastereo- and enantioselectivities.
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Mansfield Road, Oxford OX1 3TA, United Kingdom.
authors.forename: David M
authors.initials: DM
authors.lastname: Barber
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Mansfield Road, Oxford OX1 3TA, United Kingdom.
authors.forename: Andrej
authors.initials: A
authors.lastname: Duriš
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Mansfield Road, Oxford OX1 3TA, United Kingdom.
authors.forename: Amber L
authors.initials: AL
authors.lastname: Thompson
authors.affiliation: Emerging Innovations, AstraZeneca R&D, Alderley Park, Cheshire SK10 4GT, United Kingdom.
authors.forename: Hitesh J
authors.initials: HJ
authors.lastname: Sanganee
authors.affiliation: Chemistry Research Laboratory, Department of Chemistry, University of Oxford , Mansfield Road, Oxford OX1 3TA, United Kingdom.
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Dixon
keywords: cascade reactions; gold catalysis; hydroamination; nitro-Mannich; organocatalysis; pyrrolidine