title: Relationship between modeling technique and reported outcomes: case studies in models for the treatment of schizophrenia.
abstract: Complex modeling techniques such as discrete-event simulation and simpler Markov or decision-tree models have been used to estimate the cost-effectiveness of treatment for chronic diseases such as schizophrenia. A systematic literature review of MEDLINE, EconLit, Embase, and the Cochrane Library identified schizophrenia modeling studies presenting incremental cost-effectiveness ratios. The relationship between modeling technique used and reported outcomes was examined. Fifty-four studies reporting results of 69 pairs of drug comparisons were identified. Of the paired-drug comparisons, 27 were conducted in at least two studies; in 14 of the 27, the results agreed (i.e., drug A cost-effective compared with drug B) despite differences in modeling techniques. Thirteen of the 27 paired-drug comparisons had contradictory study results even when the same modeling technique was used. Different modeling techniques did not appear to explain different findings about cost-effectiveness.
authors.affiliation: RTI Health Solutions, Lund, Sweden.
authors.forename: Birgitta
authors.initials: B
authors.lastname: von Schéele
authors.forename: Josephine
authors.initials: J
authors.lastname: Mauskopf
authors.forename: Thor-Henrik
authors.initials: TH
authors.lastname: Brodtkorb
authors.forename: Claire
authors.initials: C
authors.lastname: Ainsworth
authors.forename: Carmen Galani
authors.initials: CG
authors.lastname: Berardo
authors.forename: Anita
authors.initials: A
authors.lastname: Patel
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D006801:Humans; D018803:Models, Economic; D000077152:Olanzapine; D017063:Outcome Assessment, Health Care; D018967:Risperidone / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D018967:Risperidone; D000077152:Olanzapine