title: Quantitative analysis and fingerprint profiles for quality control of Fructus Schisandrae by gas chromatography: mass spectrometry.
abstract: This paper describes a simple, rapid, and effective quality assessment method for Fructus Schisandrae by gas chromatography-mass spectrum (GC-MS). The method was established by using specific lignan fingerprint profiles and quantitation of characteristic compounds in this herbal medicine. The GC-MS fingerprints of 15 batches of Schisandra samples from different regions of China showed similar lignan profiles. Five peaks were selected as characteristic peaks, and all of these were identified by using GC-MS techniques. The relative retention times of these characteristic peaks in the GC-MS fingerprint were established as an important parameter for identification of Schisandra samples. Meanwhile, relative peak areas may be a feasible approach to discriminate the S. chinensis and S. sphenanthera. Finally, these pharmacologically active constituents in the titled plant, schisandrins A-C and schizandrols A and B, were quantitatively determined using a validated GC-MS method.
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Xia
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
authors.forename: Bing-You
authors.initials: BY
authors.lastname: Yang
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Yang
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.affiliation: Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
authors.forename: Hai-Xue
authors.initials: HX
authors.lastname: Kuang
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D017705:Lignans / Q000737:chemistry; D011786:Quality Control; D032141:Schisandra / Q000737:chemistry*; D014465:Ultrasonics
chemical_list: D004365:Drugs, Chinese Herbal; D017705:Lignans