title: Effect of fluticasone and salmeterol on tracheal responsiveness to ovalbumin and lung inflammation, administrated during and after sensitization.
abstract: The effect of duration of administration of fluticasone propionate and salmeterol on tracheal responsiveness to ovalbumin and total and differential white blood cell in sensitized guinea pig was examined. Six groups of guinea pigs (n=7) were sensitized to ovalbumin. Three groups of them were subjected to inhaled fluticasone propionate and salmeterol, one group during sensitization (A), one group after that (for 18 days, B), and the other one during sensitization but with 18 days delay before measurements (C). Three other groups were treated with placebo in the same manner. The tracheal responsiveness to ovalbumin and total and differential white blood cells of three placebo groups were significantly higher than those of control group (P<0.001 for all cases). Tracheal responsiveness to ovalbumin and total and differential white blood cell in treated groups with fluticasone propionate and salmeterol were significantly decreased compared to those of placebo groups (nonsignificant to P<0.001). The improvement in all variables in treatment groups A and C were more pronounced than group B. The results showed that fluticasone propionate and salmeterol had a prevention effect on tracheal hyperresponsiveness to ovalbumin and lung inflammation which was more pronounced when administered during than after sensitization.
authors.affiliation: Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Gholamnezhad
authors.affiliation: Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors.forename: Mohammad Hossain
authors.initials: MH
authors.lastname: Boskabady
authors.affiliation: Department of Biology, Faculty of Sciences, Kerman University of Shahid Bahonar, Kerman 9177948564, Iran.
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Khazdair
authors.affiliation: Neurogenic Inflammation Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Hosseini
authors.affiliation: Department of Biology, Faculty of Sciences, Kerman University of Shahid Bahonar, Kerman 9177948564, Iran.
authors.forename: Mahdi
authors.initials: M
authors.lastname: Abbasnejad
mesh_terms: D000420:Albuterol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000730:Androstadienes / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000068298:Fluticasone; D006168:Guinea Pigs; D009924:Organ Culture Techniques; D010047:Ovalbumin / Q000276:immunology / Q000633:toxicity*; D011014:Pneumonia / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D011897:Random Allocation; D000068299:Salmeterol Xinafoate; D014132:Trachea / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000730:Androstadienes; D000068299:Salmeterol Xinafoate; D010047:Ovalbumin; D000068298:Fluticasone; D000420:Albuterol