title: Pancreatic stone protein - a possible biomarker of multiorgan failure and mortality in children sepsis.
abstract: Pancreatic stone protein (PSP)/regenerating protein 1-alpha (reg) is associated with inflammation, infection, and other disease-related stimuli. The prognostic value of PSP/reg among critically ill pediatric patients is unknown. The aim of this pilot study was to evaluate PSP/reg in children with systemic inflammatory response syndrome or sepsis. Prospective observational study, a five day evaluation period in children 0-19years old with systemic inflammatory response syndrome or septic state. Blood tests to determine levels of PSP/reg were obtained as long as the patient met the criteria for systemic inflammatory response syndrome or sepsis. PSP/reg levels did not differ between patients with systemic inflammatory response syndrome and septic condition until organ dysfunction signs were present. PSP/reg levels were significantly higher in patients with a PELOD score of 12 or higher or in those with MODS. Patients who died tended to have higher PSP/reg levels.
authors.affiliation: University Children's Hospital, Department of Anesthesia and Intensive Care, Černopolní 9, Brno 62500, Czech Republic; Masaryk University, Černopolní 9, Brno 62500, Czech Republic. Electronic address: jzurek@fnbrno.cz.
authors.forename: Žurek
authors.initials: Ž
authors.lastname: Jiří
authors.affiliation: Masaryk University, Černopolní 9, Brno 62500, Czech Republic. Electronic address: mkyr@fnbrno.cz.
authors.forename: Michal
authors.initials: M
authors.lastname: Kýr
authors.affiliation: University Children's Hospital, Department of Anesthesia and Intensive Care, Černopolní 9, Brno 62500, Czech Republic; Masaryk University, Černopolní 9, Brno 62500, Czech Republic. Electronic address: martin.vavrina@fnbrno.cz.
authors.forename: Martin
authors.initials: M
authors.lastname: Vavřina
authors.affiliation: University Children's Hospital, Department of Anesthesia and Intensive Care, Černopolní 9, Brno 62500, Czech Republic; Masaryk University, Černopolní 9, Brno 62500, Czech Republic. Electronic address: mfedora@fnbrno.cz.
authors.forename: Michal
authors.initials: M
authors.lastname: Fedora
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051847:Lithostathine / Q000097:blood*; D008297:Male; D009102:Multiple Organ Failure / Q000097:blood* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D011446:Prospective Studies; D018805:Sepsis / Q000097:blood* / Q000401:mortality / Q000473:pathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D051847:Lithostathine; C497617:REG1A protein, human
keywords: Children; Mortality; Pancreatic stone protein; Regenerating protein 1 alpha; Sepsis