title: The utility of IFS (INECO Frontal Screening) for the detection of executive dysfunction in adults with bipolar disorder and ADHD.
abstract: Bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD) in adults share clinical symptoms. Both disorders present with executive functioning impairment. The detection of executive dysfunction usually requires the administration of an extensive neuropsychological battery. The Institute of Cognitive Neurology (INECO) Frontal Screening (IFS) is an efficient tool, which has been demonstrated to be useful for the detection of executive deficits in other diseases involving the prefrontal cortex. This study assessed the usefulness of the IFS in detecting the executive dysfunction of BD and ADHD adults, by means of a receiver-operating characteristic curve analysis and a multigroup discriminant function analysis. Twenty-four BD, 25 ADHD patients and 25 controls were assessed with a battery that included the IFS and other measures of executive functioning. Our results showed that both patient groups performed significantly lower than controls on the IFS total score. Using a 27.5 point cut-off score, the IFS showed good sensitivity and acceptable specificity to detect executive impairments in BD and ADHD patients. The IFS discriminated between controls and each patient group more reliably than other executive functions measures. Our results suggest that this tool could be a useful instrument to assess executive functions in BD and ADHD patients.
authors.affiliation: Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina; Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Argentina; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile.
authors.forename: Sandra
authors.initials: S
authors.lastname: Baez
authors.affiliation: Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina; Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Argentina; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile; Universidad Autónoma del Caribe, Barranquilla, Colombia.
authors.forename: Agustin
authors.initials: A
authors.lastname: Ibanez
authors.affiliation: Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina; Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile.
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Gleichgerrcht
authors.affiliation: Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina; Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina.
authors.forename: Ana
authors.initials: A
authors.lastname: Perez
authors.affiliation: Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina; Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile.
authors.forename: María
authors.initials: M
authors.lastname: Roca
authors.affiliation: Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina; Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina; National Scientific and Technical Research Council (CONICET), Argentina; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile; Australian Research Council (ACR) Centre of Excellence in Cognition and its Disorders, Australia.
authors.forename: Facundo
authors.initials: F
authors.lastname: Manes
authors.affiliation: Institute of Cognitive Neurology (INECO), Favaloro University, Buenos Aires, Argentina; Institute of Neuroscience, Favaloro University, Buenos Aires, Argentina; UDP-INECO Foundation Core on Neuroscience (UIFCoN), Diego Portales University, Santiago, Chile. Electronic address: ttorralva@ineco.org.ar.
authors.forename: Teresa
authors.initials: T
authors.lastname: Torralva
mesh_terms: D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology* / Q000523:psychology*; D001714:Bipolar Disorder / Q000503:physiopathology* / Q000523:psychology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D016002:Discriminant Analysis; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology*; D012372:ROC Curve
keywords: ADHD; Bipolar disorder; Executive functions; INECO Frontal Screening