title: Total and lipid bound sialic acid levels in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate serum total and lipid bound sialic acid (TSA&LBSA) levels in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Forty women with PCOS and 35 healthy controls were enrolled in the study. Serum TSA, LBSA, follicle stimulating hormone, lutenizing hormone, estradiol, thyroid stimulating hormone, prolactin, dehydroepiandrosterone sulphate, androstenedione, free testosterone, total testosterone, 17-OH progesterone, sex hormone binding globulin, cortisol, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose: insulin ratio and 75-g glucose tolerance test for 2 hours.
  
  
  RESULTS
  Serum TSA levels were not significantly different between the groups. Serum LBSA levels were higher in patients with PCOS compared to the control group. TSA was correlated with androstenedione and HOMA-IR in the PCOS group. Positive correlations were found between LBSA and dehydroepiandrosterone sulphate in patients with PCOS. After correction for BMI, the only existing significant correlation was between LBSA and follicle stimulating hormone.
  
  
  CONCLUSIONS
  Serum LBSA levels, which has previously been found to be higher in cardiovascular diseases and diabetes mellitus, are elevated in PCOS.
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ozcan
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Aykan
authors.initials: A
authors.lastname: Yücel
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Volkan
authors.initials: V
authors.lastname: Noyan
authors.affiliation: Department of Gynecology and Obstetrics, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Nevin
authors.initials: N
authors.lastname: Sağsöz
authors.affiliation: Department of Biochemistry and Clinical Biochemistry, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.
authors.forename: Osman
authors.initials: O
authors.lastname: Cağlayan
keywords: Polycystic ovary syndrome; lipid bound sialic acid; risk; total sialic acid