title: Variability of magnetoencephalographic sensor sensitivity measures as a function of age, brain volume and cortical area.
abstract: OBJECTIVE
  To assess the feasibility and appropriateness of magnetoencephalography (MEG) for both adult and pediatric studies, as well as for the developmental comparison of these factors across a wide range of ages.
  
  
  METHODS
  For 45 subjects with ages from 1 to 24years (infants, toddlers, school-age children and young adults), lead fields (LFs) of MEG sensors are computed using anatomically realistic boundary element models (BEMs) and individually-reconstructed cortical surfaces. Novel metrics are introduced to quantify MEG sensor focality.
  
  
  RESULTS
  The variability of MEG focality is graphed as a function of brain volume and cortical area. Statistically significant differences in total cerebral volume, cortical area, MEG global sensitivity and LF focality are found between age groups.
  
  
  CONCLUSIONS
  Because MEG focality and sensitivity differ substantially across the age groups studied, the cortical LF maps explored here can provide important insights for the examination and interpretation of MEG signals from early childhood to young adulthood.
  
  
  CONCLUSIONS
  This is the first study to (1) investigate the relationship between MEG cortical LFs and brain volume as well as cortical area across development, and (2) compare LFs between subjects with different head sizes using detailed cortical reconstructions.
authors.affiliation: Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles, CA 90032, USA.
authors.forename: Andrei
authors.initials: A
authors.lastname: Irimia
authors.affiliation: Multimodal Imaging Laboratory, University of California, San Diego, CA 92037, USA; Department of Radiology, University of California, San Diego, CA 92037, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Erhart
authors.affiliation: Multimodal Imaging Laboratory, University of California, San Diego, CA 92037, USA; Department of Neurosciences, University of California, San Diego, CA 92037, USA. Electronic address: ttbrown@ucsd.edu.
authors.forename: Timothy T
authors.initials: TT
authors.lastname: Brown
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007223:Infant; D015225:Magnetoencephalography / Q000379:methods / Q000592:standards*; D008297:Male; D008959:Models, Neurological; D012680:Sensitivity and Specificity; D055815:Young Adult
keywords: Boundary element method; Lead field; Magnetoencephalography; Modeling; Pediatrics