title: Cervical spine involvement in patients with juvenile idiopathic arthritis - MRI follow-up study.
abstract: BACKGROUND
  To describe MRI and clinical findings in patients with juvenile idiopathic arthritis with cervical spine involvement at onset and follow-up under therapy.
  
  
  METHODS
  13 patients with signs of cervical spine involvement in juvenile idiopathic arthritis with a median disease duration of 1.7 years were included in the study. Clinical records and MR images were retrospectively analyzed according to symptoms and findings concerning the cervical spine.
  
  
  RESULTS
  At the onset of cervical spine involvement all patients showed limited range of motion, whereas only 5 of them complained of pain. In MR images joint hyperintensity, contrast enhancement, malalignment, ankylosis, erosion and narrowing of the spinal canal at cranio-cervical junction were found at 28, 32, 15, 2, 2 and 3 sites in 12 (93%), 13 (100%), 8 (62%), 2 (15%), 2 and 3 (20%) patients respectively. 3 of the 5 patients with pain (60%) showed ankylosis, erosions or narrowing of the spinal canal at cranio-cervical junction on MRI. At follow-up - after a median disease duration of cervical spine arthritis of 2.1 years and a variable duration of treatment with methotrexate (all patients) and biological agents (12 patients) - joint hyperintensity, enhancement and malalignment decreased to 15, 19 and 6 sites in 10 (77%), 11 (85%) and 3 (20%) patients respectively whereas ankylosis, erosion and narrowing of the spinal canal at cranio-cervical junction increased to 7, 6 and 4 sites in 3 (20%), 4 (31%) and 4 patients respectively. Pain was no longer reported, but 9 of 13 (69%) patients still had a limited range of motion with 6 of them (46%) showing skeletal changes on MRI.
  
  
  CONCLUSIONS
  This first MRI based follow-up study shows that cervical spine arthritis can follow a severe disease course in juvenile arthritis. While malalignments and inflammation sites decreased osseous changes with erosions, ankylosis, and narrowing of the spinal canal increased under treatment despite only minor subjective complaints. Therefore close MRI monitoring of these patients appears to be reasonable.
authors.affiliation: Division of Pediatric Rheumatology, Children's Hospital, Olgahospital Stuttgart, teaching hospital of the University of Tuebingen, Bismarckstr, 8, 70176 Stuttgart, Germany. a.hospach@klinikum-stuttgart.de.
authors.forename: Toni
authors.initials: T
authors.lastname: Hospach
authors.forename: Jan
authors.initials: J
authors.lastname: Maier
authors.forename: Peter
authors.initials: P
authors.lastname: Müller-Abt
authors.forename: Anita
authors.initials: A
authors.lastname: Patel
authors.forename: Gerd
authors.initials: G
authors.lastname: Horneff
authors.forename: Thekla
authors.initials: T
authors.lastname: von Kalle
mesh_terms: D000293:Adolescent; D000844:Ankylosis / Q000209:etiology*; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D001685:Biological Factors / Q000627:therapeutic use*; D002574:Cervical Vertebrae / Q000473:pathology*; D002648:Child; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D017063:Outcome Assessment, Health Care; D016059:Range of Motion, Articular; D013122:Spinal Diseases / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D013130:Spinal Stenosis / Q000209:etiology*
chemical_list: D018501:Antirheumatic Agents; D001685:Biological Factors; D008727:Methotrexate