title: Invariant NKT cells: Killers and conspirators against cancer.
abstract: Although invariant natural killer T (iNKT) cells influence antitumor responsesindirectlyby secreting cytokines and promoting the cytolytic functions of T and NK cells, we find that iNKT cells mediate direct tumoricidal activity in vitro and significantly inhibit tumor growth in vivo,even in the absence of other cytotoxic lymphocytes.
authors.affiliation: Division of Infectious Diseases; Children's Hospital of Philadelphia; Philadelphia, PA USA.
authors.forename: Hamid
authors.initials: H
authors.lastname: Bassiri
authors.affiliation: Division of Oncology; Children's Hospital of Philadelphia; Philadelphia, PA USA.
authors.forename: Rupali
authors.initials: R
authors.lastname: Das
authors.affiliation: Division of Oncology; Children's Hospital of Philadelphia; Philadelphia, PA USA.
authors.forename: Kim E
authors.initials: KE
authors.lastname: Nichols
keywords: glycolipids; immunosurveillance; invariant natural killer T cells; perforin; tumor