title: An elderly woman with peripheral spondyloarthritis with aortitis.
abstract: A 75-year-old woman was admitted to our department because of backache and multiple joint pain. Serum C-reactive protein (CRP) level was 6.8 mg/dL, and serum rheumatoid factor and anti-citrullinated peptide antibody were negative. Magnetic resonance imaging (MRI) showed bone edema and synovitis of the sacroiliac joints. (18)Fluorodeoxyglucose-positron emission tomography ((18)FDG-PET) showed increased uptakes in the bilateral elbow, shoulder, sternoclavicular, hip, and sacroiliac joints. In addition, increased uptakes were also observed in the bilateral cervical and subclavian arteries, and the thoracic aorta. Moreover, inflammation of the vascular walls and an aneurism in the right subclavian artery were observed on MRI. The patient's HLA type was HLA-B48 and B60. According to the Assessment of Spondyloarthritis (ASAS) classification criteria, peripheral spondyloarthropathy (SpA) was also diagnosed. Although the diagnostic criteria of Takayasu aortitis or giant cell aortitis were not fulfilled, we thought that active aortitis was also involved, and high-dose prednisolone was started. The patient's symptoms were diminished immediately, and CRP levels returned to normal. Although the etiology of the aortitis was not certain, this is the first report of late-onset peripheral SpA with aortitis, diagnosed by (18)FDG-PET and MRI. We recommended that it is important to evaluate the aortic involvement in late-onset SpA patients, when elevated systemic inflammation is observed.
authors.affiliation: Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shoda
authors.forename: Kaoru
authors.initials: K
authors.lastname: Morita
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kanda
authors.forename: Keishi
authors.initials: K
authors.lastname: Fujio
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D001025:Aortitis / Q000150:complications* / Q000000981:diagnostic imaging; D004487:Edema / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D011877:Radionuclide Imaging; D012446:Sacroiliac Joint / Q000000981:diagnostic imaging; D025241:Spondylarthritis / Q000150:complications* / Q000000981:diagnostic imaging; D013585:Synovitis / Q000150:complications* / Q000000981:diagnostic imaging