title: Synthesis and evaluation of hydroxycamptothecin-encapsulated chitosan nanospheres for the treatment of liver cancer.
abstract: Hydroxycamptothecin-encapsulated chitosan (HC) nanospheres were prepared by Shirasu porous glass (SPG) membrane emulsification technique. The properties and morphology of HC nanospheres were characterized. The diameter of the nanospheres could be controlled within a narrow distribution according to the pore-size of SPG membrane. Hydroxycamptothecin (HCPT) encapsulation efficiency could reach to 81.3%. The long-term drug release of HCPT could be presented by an accumulated drug release of 85.4% in 15 days with an initial burst effect. In vitro study, HC showed its anti-tumor ability to human hepatoma (HepG2) cells. In vivo study, HC could reduce tumor weight and growth rate. The results indicated that HC nanospheres prepared by SPG had potential application as a sustained drug delivery system for the treatment of liver cancer.
authors.affiliation: School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China.
authors.forename: J
authors.initials: J
authors.lastname: Han
authors.affiliation: Research Center of Biomedical Engineering, College of Materials, Xiamen University, Xiamen, Fujian 361005, PR China.
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Hou
authors.affiliation: Research Center of Biomedical Engineering, College of Materials, Xiamen University, Xiamen, Fujian 361005, PR China.
authors.forename: Y G
authors.initials: YG
authors.lastname: Wang
authors.affiliation: School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, PR China guox@mail.xjtu.edu.cn.
authors.forename: X
authors.initials: X
authors.lastname: Guo
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000737:chemistry; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry; D004195:Disease Models, Animal; D004339:Drug Compounding; D065546:Drug Liberation; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D054118:Nanospheres / Q000737:chemistry / Q000648:ultrastructure; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C527042:hydroxycamptothecinum; D048271:Chitosan; D002166:Camptothecin
keywords: Chitosan; Drug delivery system; Hydroxycamptothecin; SPG