title: Impairment of work productivity in panic disorder patients.
abstract: BACKGROUND
  Panic disorder (PD) has a critical impact on productivity at the workplace. This study aimed to identify the lost productivity time (LPT) for patients with PD. It also assessed change in LPT for patients with PD after 12 weeks of treatment with Selective Serotonin Reuptake Inhibitors (SSRIs), compared with healthy controls.
  
  
  METHODS
  Working patients diagnosed with PD without other major medical or psychiatric illness were enrolled at outpatient psychiatric clinics (N=108). Age and sex-matched healthy controls were recruited through advertisement (N=108). Health and productivity, PD symptoms, and depressive symptoms were assessed using the Korean version of the World Health Organization's Health and Work Performance Questionnaire (HPQ), the Panic Disorder Severity Scale (PDSS), and the Hamilton Rating Scales for Depression (HAM-D), respectively at baseline, week 4, and week 12.
  
  
  RESULTS
  At baseline, the PD group showed significantly higher LPT compared to the control group (103.02 vs. 47.28h in the past 4 weeks). After 12 weeks of treatment, the PD group displayed significant clinical improvement as well as improved productivity with a marked reduction in LPT. Among the patients who completed the treatment, LPT due to PD was reduced from 104.38 to 55.15h in the past 4 weeks.
  
  
  CONCLUSIONS
  There may be selection bias due to case-control study design.
  
  
  CONCLUSIONS
  These data suggest that, after the treatment, there was significant improvement in clinical symptoms, and that productivity loss due to PD was almost entirely recovered to the level of healthy controls after 12 weeks of psychiatric outpatient treatment.
authors.affiliation: Stress Research Institute, Inje University, Seoul, Republic of Korea.
authors.forename: Yu
authors.initials: Y
authors.lastname: Lee Park
authors.affiliation: Stress Research Institute, Inje University, Seoul, Republic of Korea; Department of Psychiatry, Seoul Paik Hospital, Inje University, School of Medicine, Seoul, Republic of Korea.
authors.forename: Won
authors.initials: W
authors.lastname: Kim
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Chae
authors.affiliation: Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
authors.forename: Kang
authors.initials: K
authors.lastname: Seo Oh
authors.affiliation: Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Frick
authors.affiliation: Stress Research Institute, Inje University, Seoul, Republic of Korea; Department of Psychiatry, Seoul Paik Hospital, Inje University, School of Medicine, Seoul, Republic of Korea. Electronic address: jongmin.woo@gmail.com.
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Woo
mesh_terms: D000041:Absenteeism; D000328:Adult; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D004526:Efficiency; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D014937:Work
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors
keywords: Lost productivity time; Panic disorder; Productivity; SSRIs