title: Long-term survival after simultaneous pancreas-kidney transplantation with primary function of at least one year--a single-center experience.
abstract: BACKGROUND
  Simultaneous pancreas-kidney transplantation has been established as the treatment of choice for type 1 diabetes patients with renal dysfunction. Patient 1-year survival better than 95% has been achieved using this kind of transplantation. According to the postoperative complication rate (5% mortality), recipients appear to have a survival benefit not earlier than 2 years after transplantation. This study evaluates the long-term benefit of simultaneous pancreas-kidney recipients with functioning grafts after 1 year.
  
  
  METHODS
  A retrospective analysis of 176 patients after first transplantation with functioning grafts 1 year after simultaneous pancreas-kidney transplantation was performed.
  
  
  RESULTS
  During the follow-up period starting 1 year after successful transplantation, 7 patients died due to various causes, 13 pancreas grafts (7.4%) and 13 kidney transplants (7.4%) lost their function during the 10-year follow-up period. Chronic graft failure was the most common reason for transplant loss.
  
  
  CONCLUSIONS
  Our data support the excellent long-term prognosis of simultaneous pancreas-kidney transplantation recipients with functioning graft 1 year after transplantation.
authors.affiliation: Department of General Surgery, Siloah St. Trudpert Klinikum, Pforzheim, Germany.
authors.forename: Tim
authors.initials: T
authors.lastname: Schulz
authors.affiliation: Ethics Commitee, University Hospital of Schleswig-Holstein, Kiel, Germany.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Pries
authors.affiliation: Institute of Medical Informatics and Statistics, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany.
authors.forename: Amke
authors.initials: A
authors.lastname: Caliebe
authors.affiliation: Department of Surgery, Asklepios Klinik St. Georg, Hamburg, Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Kapischke
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002908:Chronic Disease; D050377:Cold Ischemia / Q000706:statistics & numerical data; D003922:Diabetes Mellitus, Type 1 / Q000401:mortality* / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000401:mortality* / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000401:mortality; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016030:Kidney Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000401:mortality*; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult