title: Effects of oleic acid-induced lung injury on oxygen transport and aerobic capacity.
abstract: We tested the hypothesis that oleic-acid (OA) infusion impairs gas exchange, decreases total cardiopulmonary O2 delivery and lowers maximal aerobic capacity ( [Formula: see text] ). We infused 0.05ml OAkg(-1) (∼3ml) and ∼563ml saline into the right atria of four goats [59.1±14.0 (SD) kg] prior to running them on a treadmill at [Formula: see text] 2-h and 1-d following OA-induced acute lung injury, and with no lung injury. Acute lung injury decreased [Formula: see text] , O2 delivery, arterial O2 concentration and arterial O2 partial pressure compared to no lung injury. The [Formula: see text] positively correlated with O2 delivery and inversely correlated with alveolar-arterial O2 partial pressure difference, suggesting that impaired pulmonary gas exchange decreased O2 delivery and uptake. Results indicate OA infusion may be a useful model for acutely impairing pulmonary gas exchange for exercise studies. Seven OA infusions induced smaller chronic gas exchange and arterial O2 partial pressure changes than acute infusion.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA.
authors.forename: George H
authors.initials: GH
authors.lastname: Crocker
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA, USA. Electronic address: jhjones@ucdavis.edu.
authors.forename: James H
authors.initials: JH
authors.lastname: Jones
mesh_terms: D000818:Animals; D001158:Arteries / Q000378:metabolism; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000502:physiology; D006041:Goats; D006339:Heart Rate / Q000187:drug effects; D016014:Linear Models; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D055370:Lung Injury / Q000139:chemically induced* / Q000378:metabolism*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D019301:Oleic Acid / Q000633:toxicity*; D009919:Orchiectomy; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D011659:Pulmonary Gas Exchange
chemical_list: D019301:Oleic Acid; D010100:Oxygen
keywords: Diffusion impairment; Exercise; Goat; Lung injury