title: The Benefits of vitamin E on liver function and the hemopoietic System in thalassemia Patients.
abstract: BACKGROUND
  β-Thalassemic children have oxidative stress and antioxidant deficiency even without iron overload status. In these patients, tissue damage due to oxidative stress may be occurred. Also, it seems that thalassemic patients have higher levels of ALT, AST therefore, the main aim of the present study was to determine the benefits of vitamin E as an antioxidant supplements in β-Thalassemia children.
  
  
  METHODS
  This clinical trial was carried out on 45 beta-thalassemic patients undergoing occasional transfusions (24 males, 21 females), mean age 16± 8 years, admitted to Yazd and Shahid Sadoughi hospital in 2011. Fallowing three months treatment of vitaminE (vitamin E 400-600 unit/day),liver function test and hemopoitic system parameters were measured.
  
  
  RESULTS
  Fourty five patients with laboratory confirmation of β-Thalassemia were recruited following three months vitamin E supplementation, liver function test had higher improvement compared to hemopoitic system parameters , and also serum SGOT was significantly reduced (P-value<0.004 ).
  
  
  CONCLUSIONS
  It seems clear that treatments of β-thalassemic patients with vitamins E have benefits in promoting antioxidant status and may improve liver function test, as AST and ALT to decrease but this supplement is not effective for hemopoietic system variables.
authors.affiliation: Department of Pediatrics, Hematology, Oncology and Genetics Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: Z
authors.initials: Z
authors.lastname: Hashemian
authors.affiliation: Department of Pediatrics, Hematology, Oncology and Genetics Research Center, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Hashemi
authors.affiliation: Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Fateminasab
keywords: Hemopoietic System; Liver Function Tests; Vitamin E