title: Preeclampsia - a risk factor for osteoporosis? Analysis of maternal Sclerostin levels and markers of bone turnover in patients with pre-eclampsia.
abstract: BACKGROUND
  The role of preeclampsia (PE) in affecting bone metabolism could not be clarified in the past years. Recently Sclerostin, a new marker of bone metabolism which is known to have an inhibitory effect on bone formation causing osteoporosis, was discovered.
  
  
  OBJECTIVE
  To investigate serum levels of Sclerostin and markers of bone turnover in women with normotensive pregnancies and pregnancies complicated by PE.
  
  
  METHODS
  In this prospective study we enrolled 22 women with PE and 22 healthy pregnant women to observe serum levels of carboxyterminal propeptide of type I collagen (PICP), cross-linked carboxyl terminal telopeptide of the type I collagen (ICTP), calcium, phosphate, 25-hydroxyvitamin D and parathyroid hormone. In 16 preeclamptic and 16 healthy pregnant women, serum Sclerostin levels were analyzed.
  
  
  RESULTS
  Serum levels of Sclerostin (mean ± standard deviation: healthy 10.5 ± 8.1 pmol/l versus PE 11.5 ± 9.4 pmol/l, p = 0.768), ICTP (healthy 0.3 ± 0.2 ng/ml versus PE 0.4 ± 0.1 ng/ml, p = 0.462), PICP (healthy 59.9 ± 49.9 ng/ml versus PE 89.0 ± 62.0 ng/ml, p = 0.094), phosphate (healthy 1.1 ± 0.2 mmol/l versus PE 1.2 ± 0.4 mmol/l, p = 0.162) and parathyroid hormone (healthy 26.9 ± 14 pg/ml versus PE 35.3 ± 17.6 pg/ml, p = 0.08) showed no significant differences between the groups. Significantly lower serum calcium (healthy 2.3 ± 0.1 mmol/l versus PE 2.2 ± 0.2 mmol/l, p < 0.005) and serum 25-Hydroxyvitamin D (healthy 39.3 ± 16.7 nmol/l versus PE 23.9 ± 16.9 nmol/l, p < 0.005) were observed in preeclamptic women.
  
  
  CONCLUSIONS
  Pregnancies complicated by PE show no signs of high bone turnover and may not lead to a higher risk of osteoporosis in later life.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Vienna , Vienna , Austria .
authors.forename: Julia
authors.initials: J
authors.lastname: Wild
authors.forename: Petra
authors.initials: P
authors.lastname: Pateisky
authors.forename: Lorenz
authors.initials: L
authors.lastname: Küssel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Huf
authors.forename: Johannes
authors.initials: J
authors.lastname: Ott
authors.forename: Peter
authors.initials: P
authors.lastname: Haslinger
authors.forename: Martin
authors.initials: M
authors.lastname: Knöfler
authors.forename: Harald
authors.initials: H
authors.lastname: Zeisler
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000328:Adult; D015415:Biomarkers / Q000097:blood; D019485:Bone Morphogenetic Proteins / Q000097:blood*; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D005260:Female; D005819:Genetic Markers; D006801:Humans; D010024:Osteoporosis / Q000097:blood / Q000209:etiology*; D010281:Parathyroid Hormone / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood; D055815:Young Adult
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D015415:Biomarkers; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; D010281:Parathyroid Hormone; C422903:SOST protein, human; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium
keywords: Bone turnover; Carboxyterminal propeptide of type I collagen (PICP); Cross-linked carboxyl terminal telopeptide of the type I collagen (ICTP); Preeclampsia; Sclerostin