title: Rice bran and raspberry seed oil-based nanocarriers with self-antioxidative properties as safe photoprotective formulations.
abstract: The aim of this research was to develop advanced lipid nanocarriers based on renewable vegetable resources (rice bran oil and raspberry seed oil) that possess self-antioxidative properties, having advantages in terms of minimal side effects and exhibiting the ability to simultaneously co-encapsulate and co-release two active compounds. The focus has been oriented towards developing safe cosmetic formulations with broad-spectrum photoprotection based on these new lipid nanocarriers that contain large amounts of vegetable oils and low concentrations of synthetic UVA and UVB filters (butyl-methoxydibenzoylmethane - BMDBM and octocrylene - OCT). The lipid nanocarriers have a spherical shape and show good physical stability, with a zeta potential in the range of -25.5 to -32.4 mV. Both vegetable oils play a key role in the preparation of efficient nanocarriers, leading to a less ordered arrangement of the lipid core that offers many spaces for the entrapment of large amounts of BMDBM (79%) and OCT (90%), as wells as improved antioxidant activity and UV absorption properties, particularly for the lipid nanocarriers prepared from rice bran oil. By formulating the lipid nanocarriers into creams containing only 3.5% of the UV filters and 10.5% of the vegetable oils, the resulting sunscreens exhibited improved photoprotection, reflecting up to 91% and 93% of UVA and UVB rays, respectively. A new direction of research achieved by this study is the multiple release strategy of both UV filters from the same lipid nanocarrier. After 24 hours, a slow release of BMDBM (less than 4%) and OCT (17.5%) was obtained through a Fick diffusion process. This study demonstrates a significant advance in the areas of both nanotechnology and cosmetics, developing safer cosmetic formulations that possess broad antioxidant, photoprotective and co-release effectiveness due to the existence of a high content of nanostructured vegetable oils combined with a low amount of synthetic UV filters in the same carrier system.
authors.affiliation: University POLITEHNICA of Bucharest, Faculty of Applied Chemistry and Materials Science, Polizu Street No 1, 011061, Bucharest, Romania. a.meghea@gmail.com.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Niculae
authors.forename: Ioana
authors.initials: I
authors.lastname: Lacatusu
authors.forename: Nicoleta
authors.initials: N
authors.lastname: Badea
authors.forename: Raluca
authors.initials: R
authors.lastname: Stan
authors.forename: Bogdan Stefan
authors.initials: BS
authors.lastname: Vasile
authors.forename: Aurelia
authors.initials: A
authors.lastname: Meghea
mesh_terms: D065638:Absorption, Radiation; D000179:Acrylates / Q000737:chemistry; D000473:Alkanes / Q000737:chemistry; D000975:Antioxidants / Q000737:chemistry; D047188:Chalcones / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003358:Cosmetics / Q000737:chemistry; D003460:Crystallization; D004058:Diffusion; D004355:Drug Stability; D005638:Fruit / Q000737:chemistry*; D007700:Kinetics; D008055:Lipids / Q000737:chemistry; D053769:Nanocapsules / Q000737:chemistry*; D012275:Oryza / Q000737:chemistry*; D010316:Particle Size; D055668:Photochemical Processes; D010938:Plant Oils / Q000737:chemistry*; D011427:Propiophenones; D012639:Seeds / Q000737:chemistry*; D013473:Sunscreening Agents / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D000179:Acrylates; D000473:Alkanes; D000975:Antioxidants; D047188:Chalcones; D003358:Cosmetics; D008055:Lipids; D053769:Nanocapsules; D010938:Plant Oils; D011427:Propiophenones; D013473:Sunscreening Agents; C088673:octocrylene; C049935:avobenzone