title: [Vancomycin resistant Staphylococcus epidermidis caused prosthesis infection. Linezolid and rifampicin healed the complicated infection].
abstract: Coagulase-negative Staphylococci, including Staphylococcus epidermidis, are common pathogens in orthopedic prosthesis infections. Operation and prolonged treatment with rifampicin in combination with another antibiotic is often required. Coagulase-negative Staph-ylococci are frequently multi-resistant, but resistance to vancomycin is rare in Sweden. Linezolid is an alternative, however it is only recommended for up to 4 weeks treatment due to risk of hematological side effects. We have successfully used prolonged treatment with linezolid and rifampicin in a patient suffering from a complicated prosthetic joint infection caused by a vancomycin resistant Staphyloccous epidermidis strain.
authors.affiliation: Infektion/Venhälsan - Södersjukhuset Stockholm, Sweden Infektion/Venhälsan - Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Håkanson
authors.affiliation: Klinisk mikrobiologi - Karolinska Universitetslaboratoriet Huddinge, Sweden - Klinisk mikrobiologi Stockholm, Sweden.
authors.forename: Inga
authors.initials: I
authors.lastname: Fröding
authors.affiliation: Ortopedkliniken - Södersjukhuset Stockholm, Sweden Ortopedkliniken - Södersjukhuset Stockholm, Sweden.
authors.forename: Carin
authors.initials: C
authors.lastname: Ottosson
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects; D000069349:Linezolid; D008297:Male; D008875:Middle Aged; D023303:Oxazolidinones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D012293:Rifampin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000302:isolation & purification; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D020713:Vancomycin Resistance
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D014640:Vancomycin; D000069349:Linezolid; D012293:Rifampin