title: Effect of photodynamic therapy on the mechanical strength of healed rodent skin incisions.
abstract: A factor that might complicate the use of intraoperative photodynamic therapy (PDT) is a possible adverse effect on normal tissue recovery. In this study, rats with experimental skin incisions received intraoperative PDT (10 mg/kg haematoporphyrin derivative, 180 J/cm(2) laser light), immediately followed by closure. Healing was evaluated by tensile strength assessment of the incisions 21 days after PDT. No significant differences between the PDT-treated group and control groups were found. We therefore concluded that with respect to healing of skin incisions in rats, intraoperative PDT is not contraindicated.
authors.affiliation: Laser Centre, Academic Medical Centre, Amsterdam, The Netherlands, NL.
authors.forename: P A
authors.initials: PA
authors.lastname: Brouwer
authors.forename: F W
authors.initials: FW
authors.lastname: Van Der Meulen
authors.forename: E J
authors.initials: EJ
authors.lastname: Timmenga
authors.forename: M J
authors.initials: MJ
authors.lastname: van Gemert