title: Effect of nicardipine on renal function following robot-assisted laparoscopic radical prostatectomy in patients with pre-existing renal insufficiency.
abstract: OBJECTIVE
  To investigate the renoprotective effect of nicardipine in patients with pre-existing renal insufficiency undergoing robot-assisted laparoscopic radical prostatectomy (RALRP).
  
  
  METHODS
  Men with preoperative renal insufficiency (estimated glomerular filtration rate [eGFR] <60 ml/min per 1.73 m(2)) were enrolled and randomized to receive either 0.5 µg/kg per min nicardipine continuous infusion (nicardipine group) or normal saline (control group) during RALRP. Renal function was determined by eGFR and serum creatinine concentration.
  
  
  RESULTS
  Serum creatinine levels on postoperative days (POD) 1 and 3 were significantly lower than baseline values in the nicardipine group (n = 50). In the control group (n = 50), eGFR was significantly higher on POD 3 than baseline, and was significantly higher than baseline on POD 1 and 3 in the nicardipine group. The change in eGFR from baseline to POD 1 was significantly higher in the nicardipine group than the control group.
  
  
  CONCLUSIONS
  Continuous infusion of nicardipine during RALRP improved postoperative renal function on POD 1 in patients with pre-existing renal insufficiency.
authors.affiliation: Department of Anaesthesia and Pain Medicine, Anam Hospital, Korea University, Seoul, South Korea.
authors.forename: Hyub
authors.initials: H
authors.lastname: Huh
authors.forename: Na Young
authors.initials: NY
authors.lastname: Kim
authors.forename: Seol Ju
authors.initials: SJ
authors.lastname: Park
authors.forename: Jang Eun
authors.initials: JE
authors.lastname: Cho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007677:Kidney Function Tests; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009529:Nicardipine / Q000627:therapeutic use*; D011027:Pneumoperitoneum; D011446:Prospective Studies; D011467:Prostate / Q000601:surgery; D011468:Prostatectomy; D051437:Renal Insufficiency / Q000517:prevention & control*; D012371:Robotics
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D003404:Creatinine; D009529:Nicardipine
keywords: Nicardipine; renal insufficiency; robot-assisted surgery