title: Comparison of the osteogenic potential of OsteoSelect demineralized bone matrix putty to NovaBone calcium-phosphosilicate synthetic putty in a cranial defect model.
abstract: The purpose of this study was to compare the osteogenic potential of a synthetic and a demineralized bone matrix (DBM) putty using a cranial defect model in New Zealand white rabbits. Paired, bilateral critical-size defects (10 mm) were prepared in the frontal bones of 12 rabbits and filled with either OsteoSelect DBM Putty or NovaBone calcium-phosphosilicate putty. At days 43 and 91, 6 rabbits were killed and examined via semiquantitative histology and quantitative histomorphometry. Defects filled with the DBM putty were histologically associated with less inflammation and fibrous tissue in the defect and more new bone than the synthetic counterpart at both time points. Histomorphometric analysis revealed that the defects filled with DBM putty were associated with significantly more bone formation at day 43 (70.7% vs 40.7%, P = 0.043) and at day 91 (70.4% vs 39.9%, P = 0.0044). The amount of residual implant was similar for both test groups at each time point.
authors.affiliation: From the *Bacterin International Inc, Belgrade, Montana; and†Applied Biological Concepts, Inc, Los Alamitos, California.
authors.forename: Mark A
authors.initials: MA
authors.lastname: Schallenberger
authors.forename: Kerri
authors.initials: K
authors.lastname: Rossmeier
authors.forename: Helena M
authors.initials: HM
authors.lastname: Lovick
authors.forename: Todd R
authors.initials: TR
authors.lastname: Meyer
authors.forename: Harold M
authors.initials: HM
authors.lastname: Aberman
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Juda
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D001857:Bone Matrix / Q000637:transplantation*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates; D002516:Ceramics; D004195:Disease Models, Animal; D005260:Female; D005624:Frontal Bone / Q000293:injuries / Q000601:surgery*; D010012:Osteogenesis / Q000502:physiology; D011817:Rabbits; D012887:Skull Fractures / Q000473:pathology / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; C022107:Bioglass; D018786:Bone Substitutes; D002130:Calcium Phosphates