title: Local control of repeated-dose rectal challenges in DNA/MVA-vaccinated macaques protected against a first series of simian immunodeficiency virus challenges.
abstract: Here, we report the results of a late boost and three additional series of simian immunodeficiency virus (SIV) challenges in seven DNA/modified vaccinia virus Ankara (MVA)-vaccinated rhesus macaques who resisted a first series of rectal challenges. During 29 additional challenges delivered over 2.3 years, all animals became infected. However, 13 blips of virus in six macaques and anamnestic Env-specific rectal IgA responses in three of the six suggested that local control of infections was occurring during the serial challenge.
authors.affiliation: Division of Microbiology and Immunology, Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kannanganant
authors.forename: Salaija
authors.initials: S
authors.lastname: Gangadhara
authors.forename: Lilin
authors.initials: L
authors.lastname: Lai
authors.forename: Benton
authors.initials: B
authors.lastname: Lawson
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Kozlowski
authors.forename: Harriet L
authors.initials: HL
authors.lastname: Robinson
authors.forename: Rama Rao
authors.initials: RR
authors.lastname: Amara
mesh_terms: D000818:Animals; D004337:Drug Carriers; D018928:Immunity, Mucosal; D008253:Macaca mulatta; D012007:Rectum / Q000276:immunology*; D018449:SAIDS Vaccines / Q000008:administration & dosage / Q000276:immunology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000517:prevention & control*; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology; D014616:Vaccinia virus / Q000235:genetics
chemical_list: D004337:Drug Carriers; D018449:SAIDS Vaccines; D019444:Vaccines, DNA; D014614:Vaccines, Synthetic