title: Regioselective hydration of terminal halo-substituted propargyl carboxylates by gold catalyst: synthesis of α-acyloxy α'-halo ketones.
abstract: Regioselective hydration of the terminal halo-substituted propargyl carboxylate by gold(I) catalyst is reported. The mild catalytic conditions tolerate common acid-labile protecting groups, and a wide variety of α-acyloxy α'-halo ketones are efficiently synthesized within a short reaction time. The α-acyloxy α'-halo ketones are used for the synthesis of 2-aminothiazoles.
authors.affiliation: School of Chemistry, University of Hyderabad , Hyderabad 500046, India.
authors.forename: Nayan
authors.initials: N
authors.lastname: Ghosh
authors.forename: Sanatan
authors.initials: S
authors.lastname: Nayak
authors.forename: B
authors.initials: B
authors.lastname: Prabagar
authors.forename: Akhila K
authors.initials: AK
authors.lastname: Sahoo