title: Copper-catalyzed oxidative coupling of formamides with salicylaldehydes: synthesis of carbamates in the presence of a sensitive aldehyde group.
abstract: A diverse library of novel carbamates was synthesized utilizing copper-catalyzed oxidative C-O coupling of formamides and salicylaldehydes. Sensitive aldehyde groups remained intact in the presence of an oxidant and a transition-metal salt. Salicylaldehydes bearing electron-donating, electron-withdrawing, and halogen groups as well as 1-hydroxy-2-naphthaldehydes provided the desired carbamates in good to excellent yields.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University , Kaohsiung 807, Taiwan.
authors.forename: Balaji D
authors.initials: BD
authors.lastname: Barve
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Mohamed
authors.initials: M
authors.lastname: El-Shazly
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Chuang
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: Jeh-Jeng
authors.initials: JJ
authors.lastname: Wang
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005559:Formamides / Q000737:chemistry*; D015394:Molecular Structure; D058451:Oxidative Coupling
chemical_list: D000447:Aldehydes; D002219:Carbamates; D005559:Formamides; C013243:salicylaldehyde; D003300:Copper