title: The prevalence, clinical correlates and structure of phobic fears in Han Chinese women with recurrent major depression.
abstract: BACKGROUND
  Phobic fears are common in the general population and among individuals with major depression (MD). We know little about the prevalence, clinical correlates, and structure of phobic fears in Chinese women with MD.
  
  
  METHODS
  We assessed 22 phobic fears in 6017 Han Chinese women with MD. We used exploratory factor analysis to examine the structure of these phobic fears. We examined the relationship between individual phobic fears and the severity of MD, neuroticism, comorbid panic disorder, generalized anxiety disorder and dysthymia using logistic regression models.
  
  
  RESULTS
  The frequency of phobic fears ranged from 3.0% (eating in public) to 36.0% (snakes). Phobic fears were significantly associated with more severe MD, high neuroticism, and co-morbid panic disorder, generalized anxiety disorder and dysthymia. Our factor analysis suggested four underlying subgroups of phobic fears which differed in their clinical correlates, severity and patterns of comorbidity.
  
  
  CONCLUSIONS
  Data were collected retrospectively through interview and recall bias may have affected the results.
  
  
  CONCLUSIONS
  Phobic fears are correlated with comorbid MD and more severe MD. These phobic fears clearly subdivide into four subgroups that differ meaningfully from each other.
authors.affiliation: Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, People׳s Republic of China.
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authors.affiliation: Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom.
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authors.affiliation: Virginia Commonwealth University, Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA, USA. Electronic address: kendler@vcu.edu.
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mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000453:epidemiology; D044466:Asian People; D002681:China / Q000453:epidemiology; D015897:Comorbidity; D003865:Major Depressive Disorder / Q000453:epidemiology*; D019263:Dysthymic Disorder / Q000453:epidemiology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D000075384:Neuroticism; D016584:Panic Disorder / Q000453:epidemiology; D010698:Phobic Disorders / Q000453:epidemiology*; D015995:Prevalence; D012008:Recurrence; D012189:Retrospective Studies
keywords: Comorbidity; Factor analysis; Major depression; Phobic fear; Prevalence