title: Evaluation of novel trans-sulfonamide platinum complexes against tumor cell lines.
abstract: Platinum-based drugs, mainly cisplatin, are employed for the treatment of solid malignancies. However, cisplatin treatment often results in the development of chemoresistance, leading to therapeutic failure. Here, the antitumor activity of different trans-sulfonamide platinum complexes in a panel of human cell lines is presented. The cytotoxicity profiles and cell cycle analyses of these platinum sulfonamide complexes were different from those of cisplatin. These studies showed that complex 2b with cyclohexyldiamine and dansyl moieties had the best antitumoral activities.
authors.affiliation: Medical Oncology Service, Hospital Universitario 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Pérez
authors.affiliation: Medical Oncology Service, Hospital Universitario 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain.
authors.forename: C Vanesa
authors.initials: CV
authors.lastname: Díaz-García
authors.affiliation: Medical Oncology Service, Hospital Universitario 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Agudo-López
authors.affiliation: Inorganic Chemistry Department (Módulo 7), Universidad Autónoma de Madrid, C/Fco Tomás y Valiente, 5, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: del Solar
authors.affiliation: Inorganic Chemistry Department (Módulo 7), Universidad Autónoma de Madrid, C/Fco Tomás y Valiente, 5, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Cabrera
authors.affiliation: Medical Oncology Service, Hospital Universitario 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain.
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Agulló-Ortuño
authors.affiliation: Inorganic Chemistry Department (Módulo 7), Universidad Autónoma de Madrid, C/Fco Tomás y Valiente, 5, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Navarro-Ranninger
authors.affiliation: Organic Chemistry Department (Módulo 1), Universidad Autónoma de Madrid, C/Fco Tomás y Valiente, 5, Cantoblanco, 28049 Madrid, Spain. Electronic address: jose.aleman@uam.es.
authors.forename: José
authors.initials: J
authors.lastname: Alemán
authors.affiliation: Medical Oncology Service, Hospital Universitario 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain; Instituto de Investigación Hospital 12 de Octubre, Avda de Córdoba S/N, 28041 Madrid, Spain. Electronic address: jlmartin@salud.madrid.org.
authors.forename: José A
authors.initials: JA
authors.lastname: López-Martín
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D020552:Comet Assay; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D013058:Mass Spectrometry; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000494:pharmacology*; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D013449:Sulfonamides
keywords: Cell cycle analyses; Cytotoxicity profiles; Sulfonamides; trans-platinum complexes