title: Epidemiological studies of migration and environmental risk factors in the inflammatory bowel diseases.
abstract: Inflammatory bowel diseases (IBD) are idiopathic chronic diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk factors. Permissive genotypes may manifest into clinical phenotypes under certain environmental influences and these may be best studied from migratory studies. Exploring differences between first and second generation migrants may further highlight the contribution of environmental factors towards the development of IBD. There are few opportunities that have been offered so far. We aim to review the available migration studies on IBD, evaluate the known environmental factors associated with IBD, and explore modern migration patterns to identify new opportunities and candidate migrant groups in IBD migration research.
authors.affiliation: Yanna Ko, Rhys Butcher, Rupert W Leong, Concord Hospital, Gastroenterology and Liver Services and The University of New South Wales, Sydney NSW 2139, Australia.
authors.forename: Yanna
authors.initials: Y
authors.lastname: Ko
authors.affiliation: Yanna Ko, Rhys Butcher, Rupert W Leong, Concord Hospital, Gastroenterology and Liver Services and The University of New South Wales, Sydney NSW 2139, Australia.
authors.forename: Rhys
authors.initials: R
authors.lastname: Butcher
authors.affiliation: Yanna Ko, Rhys Butcher, Rupert W Leong, Concord Hospital, Gastroenterology and Liver Services and The University of New South Wales, Sydney NSW 2139, Australia.
authors.forename: Rupert W
authors.initials: RW
authors.lastname: Leong
mesh_terms: D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D003424:Crohn Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics; D054242:Emigrants and Immigrants; D004641:Emigration and Immigration / Q000639:trends*; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D015995:Prevalence; D044469:Racial Groups / Q000235:genetics; D012307:Risk Factors; D013997:Time Factors
keywords: Crohn’s disease; Environment; Epidemiology; Hygiene hypothesis; Inflammatory bowel disease; Risk factor; Ulcerative colitis