title: The association between genetic variants of RUNX2, ADIPOQ and vertebral fracture in Korean postmenopausal women.
abstract: Contrary to the traditional belief that obesity acts as a protective factor for bone, recent epidemiologic studies have shown that body fat might be a risk factor for osteoporosis and bone fracture. Accordingly, we evaluated the association between the phenotypes of osteoporosis or vertebral fracture and variants of obesity-related genes, peroxisome proliferator-activated receptor-gamma (PPARG), runt-related transcription factor 2 (RUNX2), leptin receptor (LEPR), and adiponectin (ADIPOQ). In total, 907 postmenopausal healthy women, aged 60-79 years, were included in this study. BMD and biomarkers of bone health and adiposity were measured. We genotyped for four single nucleotide polymorphisms (SNPs) from four genes (PPARG, RUNX2, LEPR, ADIPOQ). A general linear model for continuous dependent variables and a logistic regression model for categorical dependent variables were used to analyze the statistical differences among genotype groups. Compared with the TT subjects at rs7771980 in RUNX2, C-carrier (TC + CC) subjects had a lower vertebral fracture risk after adjusting for age, smoking, alcohol, total calorie intake, total energy expenditure, total calcium intake, total fat intake, weight, body fat. Odds ratio (OR) and 95% interval (CI) for the vertebral fracture risk was 0.55 (95% CI 0.32-0.94). After adjusting for multiple variables, the prevalence of vertebral fracture was highest in GG subjects at rs1501299 in ADIPOQ (p = 0.0473). A high calcium intake (>1000 mg/day) contributed to a high bone mineral density (BMD) in GT + TT subjects at rs1501299 in ADIPOQ (p for interaction = 0.0295). Even if the mechanisms between obesity-related genes and bone health are not fully established, the results of our study revealed the association of certain SNPs from obesity-related genes with BMD or vertebral fracture risk in postmenopausal Korean women.
authors.affiliation: Department of Family Medicine, Chaum Hospital, Cha University, Seoul, Korea, joyks71@gmail.com.
authors.forename: Kyong-Chol
authors.initials: KC
authors.lastname: Kim
authors.forename: Hyejin
authors.initials: H
authors.lastname: Chun
authors.forename: ChaoQiang
authors.initials: C
authors.lastname: Lai
authors.forename: Laurence D
authors.initials: LD
authors.lastname: Parnell
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Jongho
authors.initials: J
authors.lastname: Lee
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ordovas
mesh_terms: D052242:Adiponectin / Q000235:genetics*; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001835:Body Weight / Q000235:genetics; D015519:Bone Density / Q000235:genetics; D050659:Core Binding Factor Alpha 1 Subunit / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000235:genetics; D015663:Osteoporosis, Postmenopausal / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017698:Postmenopause / Q000235:genetics*; D016103:Spinal Fractures / Q000235:genetics*
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D050659:Core Binding Factor Alpha 1 Subunit; C493709:RUNX2 protein, human