title: Endothelial health in childhood acute lymphoid leukemia survivors: pilot evaluation with peripheral artery tonometry.
abstract: BACKGROUND
  Childhood cancer survivors are a growing population at risk for poor cardiac outcomes. Acute lymphoid leukemia (ALL) survivors are among those at increased risk of cardiovascular complications. Early identification of impaired vascular health may allow for interventions to improve these outcomes. The purpose of this study was to evaluate vascular health using peripheral artery tonometry in ALL survivors and compare results with healthy siblings.
  
  
  METHODS
  Sixteen ALL survivor, healthy sibling pairs, aged 8 to 20 years, were evaluated for vascular health and cardiovascular risk factors (body mass index, central adiposity, blood pressure, and fitness). One-tailed paired t test was used to compare the groups.
  
  
  RESULTS
  Survivors were similar to siblings in cardiovascular risk measures but had poorer vascular health as measured by reactive hyperemia index (survivor RHI 1.54 vs. sibling 1.77; P=0.0474).
  
  
  CONCLUSIONS
  This study reveals that even among survivors who are comparable to their healthy siblings in other traditional cardiovascular risks, there is evidence of poorer vascular health.
authors.affiliation: *Division of Pediatric Oncology, School of Medicine, Bloomberg Children's Center, Johns Hopkins University ‡Department of Community-Public Health, School of Nursing, Johns Hopkins University, Baltimore, MD †Institute of Public and Preventive Health, Georgia Regents University, Augusta, GA.
authors.forename: Kathy
authors.initials: K
authors.lastname: Ruble
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Davis
authors.forename: Hae-Ra
authors.initials: HR
authors.lastname: Han
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D003131:Combined Modality Therapy; D004700:Endocrine System Diseases / Q000175:diagnosis* / Q000209:etiology; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods*; D058729:Peripheral Arterial Disease / Q000175:diagnosis* / Q000209:etiology; D016491:Peripheral Vascular Diseases / Q000175:diagnosis* / Q000209:etiology; D010865:Pilot Projects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors; D035781:Siblings; D015996:Survival Rate; D017741:Survivors; D055815:Young Adult