title: Development of a stereotaxic device for low impact implantation of neural constructs or pieces of neural tissues into the mammalian brain.
abstract: Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity of the constructs during and after their transplantation. Here, novel technology has been developed that allows for the implantation of neural constructs or intact pieces of neural tissue into the CNS with low trauma. By "laying out" (instead of forcibly expelling) the implantable material from a thin walled glass capillary, this technology has the potential to enhance neural transplantation procedures by reducing trauma to the host brain during implantation and allowing for the implantation of engineered/dissected tissues or constructs in such a way that their orientation and integrity are maintained in the host. Such technology may be useful for treating various CNS disorders which require the reestablishment of point-to-point contacts (e.g., Parkinson's disease) across the adult CNS, an environment which is not normally permissive to axonal growth.
authors.affiliation: Institute for Science and Technology in Medicine (Hartshill Campus), Medical School, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK.
authors.forename: Andrzej
authors.identifier: 0000-0002-6960-0851
authors.initials: A
authors.lastname: Jozwiak
authors.affiliation: Institute for Science and Technology in Medicine, School of Life Sciences, Keele University, Keele ST5 5BG, UK.
authors.forename: Yiwen
authors.identifier: 0000-0002-4728-1319
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Institute for Science and Technology in Medicine (Hartshill Campus), Medical School, Keele University, Thornburrow Drive, Hartshill, Stoke-on-Trent ST4 7QB, UK.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.affiliation: Institute for Science and Technology in Medicine, School of Life Sciences, Keele University, Keele ST5 5BG, UK.
authors.forename: Monte A
authors.initials: MA
authors.lastname: Gates
mesh_terms: D000818:Animals; D001921:Brain / Q000601:surgery*; D002490:Central Nervous System / Q000601:surgery*; D006801:Humans; D010300:Parkinson Disease / Q000473:pathology / Q000601:surgery; D013238:Stereotaxic Techniques / Q000295:instrumentation*; D023822:Tissue Engineering