title: [Chronic obstructive pulmonary disease (COPD). Current concepts and new therapeutic options].
abstract: Chronic obstructive pulmonary disease (COPD) is a very common chronic disease with increasing prevalence. Inhaled particles and gases (in particular tobacco smoke) induce chronic inflammation of the airways accompanied by a not fully reversible airflow limitation. Destruction of lung tissue and deterioration of gas exchange may follow. In parallel, several comorbidities can be observed. The COPD assessment was revised and now takes into account lung function, the patients' symptoms, and history of exacerbations. More recently, several new long-acting bronchodilators received approval. Combination products, consisting of long-acting β2-agonists and long-acting anticholinergics, and a new combination of a long-acting β-agonist and an inhaled corticosteroid will follow in the near future. Smoking cessation is of central importance.
authors.affiliation: Klinik für Innere Medizin mit Schwerpunkt Pneumologie, Universitätsklinikum Gießen und Marburg, Standort Marburg, Baldingerstr. 1, 35043, Marburg, Deutschland, klemmer@med.uni-marburg.de.
authors.forename: A
authors.initials: A
authors.lastname: Klemmer
authors.forename: T
authors.initials: T
authors.lastname: Greulich
authors.forename: A R
authors.initials: AR
authors.lastname: Koczulla
authors.forename: C F
authors.initials: CF
authors.lastname: Vogelmeier
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000403:Airway Resistance / Q000187:drug effects; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D017277:Drug Approval; D004338:Drug Combinations; D015507:Drugs, Investigational / Q000627:therapeutic use*; D005858:Germany; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D012129:Respiratory Function Tests; D016540:Smoking Cessation
chemical_list: D000305:Adrenal Cortex Hormones; D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D018680:Cholinergic Antagonists; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D015507:Drugs, Investigational