title: Alpha-synuclein repeat variants and survival in Parkinson's disease.
abstract: OBJECTIVE
  To determine whether α-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD).
  
  
  METHODS
  Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival.
  
  
  RESULTS
  Twenty-one sites contributed data for 6,154 cases. There was no significant association between α-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01).
  
  
  CONCLUSIONS
  In our large consortium study, α-synuclein REP1 genotypes were not associated with survival in PD. Further studies of α-synuclein's role in disease progression and long-term outcomes are needed.
authors.affiliation: Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Sun Ju
authors.initials: SJ
authors.lastname: Chung
authors.forename: Joanna M
authors.initials: JM
authors.lastname: Biernacka
authors.forename: Sebastian M
authors.initials: SM
authors.lastname: Armasu
authors.forename: Kari
authors.initials: K
authors.lastname: Anderson
authors.forename: Roberta
authors.initials: R
authors.lastname: Frigerio
authors.forename: Jan O
authors.initials: JO
authors.lastname: Aasly
authors.forename: Grazia
authors.initials: G
authors.lastname: Annesi
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Bentivoglio
authors.forename: Laura
authors.initials: L
authors.lastname: Brighina
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Chartier-Harlin
authors.forename: Stefano
authors.initials: S
authors.lastname: Goldwurm
authors.forename: Georgios
authors.initials: G
authors.lastname: Hadjigeorgiou
authors.forename: Barbara
authors.initials: B
authors.lastname: Jasinska-Myga
authors.forename: Beom Seok
authors.initials: BS
authors.lastname: Jeon
authors.forename: Yun Joong
authors.initials: YJ
authors.lastname: Kim
authors.forename: Rejko
authors.initials: R
authors.lastname: Krüger
authors.forename: Suzanne
authors.initials: S
authors.lastname: Lesage
authors.forename: Katerina
authors.initials: K
authors.lastname: Markopoulou
authors.forename: George
authors.initials: G
authors.lastname: Mellick
authors.forename: Karen E
authors.initials: KE
authors.lastname: Morrison
authors.forename: Andreas
authors.initials: A
authors.lastname: Puschmann
authors.forename: Eng-King
authors.initials: EK
authors.lastname: Tan
authors.forename: David
authors.initials: D
authors.lastname: Crosiers
authors.forename: Jessie
authors.initials: J
authors.lastname: Theuns
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Karin
authors.initials: K
authors.lastname: Wirdefeldt
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
authors.forename: Alexis
authors.initials: A
authors.lastname: Elbaz
authors.forename: Demetrius M
authors.initials: DM
authors.lastname: Maraganore
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D018900:Dinucleotide Repeats / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics* / Q000401:mortality; D013534:Survival; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: D051844:alpha-Synuclein
keywords: Parkinson's disease; association; gene; survival; α-synuclein