title: Identification of volatile organic compounds in human cerumen.
abstract: We report here the initial examination of volatile organic compounds (VOCs) emanating from human earwax (cerumen). Recent studies link a single nucleotide polymorphism (SNP) in the adenosine triphosphate (ATP) binding cassette, sub-family C, member 11 gene (ABCC11) to the production of different types of axillary odorants and cerumen. ABCC11 encodes an ATP-driven efflux pump protein that plays an important function in ceruminous apocrine glands of the auditory canal and the secretion of axillary odor precursors. The type of cerumen and underarm odor produced by East Asians differ markedly from that produced by non-Asians. In this initial report we find that both groups emit many of the same VOCs but differ significantly in the amounts produced. The principal odorants are volatile organic C2-to-C6 acids. The physical appearance of cerumen from the two groups also matches previously reported ethnic differences, viz., cerumen from East Asians appears dry and white while that from non-Asians is typically wet and yellowish-brown.
authors.affiliation: Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA. Electronic address: kprigge@monell.org.
authors.forename: Katharine A
authors.initials: KA
authors.lastname: Prokop-Prigge
authors.affiliation: Department of Otorhinolaryngology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Erica
authors.initials: E
authors.lastname: Thaler
authors.affiliation: Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA; School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Wysocki
authors.affiliation: Monell Chemical Senses Center, 3500 Market Street, Philadelphia, PA 19104, USA; Department of Dermatology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: George
authors.initials: G
authors.lastname: Preti
mesh_terms: D000328:Adult; D044466:Asian People; D002571:Cerumen / Q000737:chemistry*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008297:Male; D052617:Solid Phase Microextraction; D055549:Volatile Organic Compounds / Q000032:analysis* / Q000737:chemistry; D044465:White People
chemical_list: D055549:Volatile Organic Compounds
keywords: Axillary odor; Cerumen; Earwax; GC/MS; SPME; Volatile organic compounds