title: Fish oil diet associated with acute reperfusion related hemorrhage, and with reduced stroke-related sickness behaviors and motor impairment.
abstract: Ischemic stroke is associated with motor impairment and increased incidence of affective disorders such as anxiety/clinical depression. In non-stroke populations, successful management of such disorders and symptoms has been reported following diet supplementation with long chain omega-3-polyunsaturated-fatty-acids (PUFAs). However, the potential protective effects of PUFA supplementation on affective behaviors after experimentally induced stroke and sham surgery have not been examined previously. This study investigated the behavioral effects of PUFA supplementation over a 6-week period following either middle cerebral artery occlusion or sham surgery in the hooded-Wistar rat. The PUFA diet supplied during the acclimation period prior to surgery was found to be associated with an increased risk of acute hemorrhage following the reperfusion component of the surgery. In surviving animals, PUFA supplementation did not influence infarct size as determined 6 weeks after surgery, but did decrease omega-6-fatty-acid levels, moderate sickness behaviors, acute motor impairment, and longer-term locomotor hyperactivity and depression/anxiety-like behavior.
authors.affiliation: Brain Sciences Institute, Swinburne University , Melbourne, VIC , Australia.
authors.forename: Michaela C
authors.initials: MC
authors.lastname: Pascoe
authors.affiliation: Florey Neuroscience Institutes , Melbourne, VIC , Australia.
authors.forename: David W
authors.initials: DW
authors.lastname: Howells
authors.affiliation: Brain Sciences Institute, Swinburne University , Melbourne, VIC , Australia.
authors.forename: David P
authors.initials: DP
authors.lastname: Crewther
authors.affiliation: School of Psychology, Deakin University , Geelong, VIC , Australia.
authors.forename: Nicki
authors.initials: N
authors.lastname: Constantinou
authors.affiliation: Florey Neuroscience Institutes , Melbourne, VIC , Australia.
authors.forename: Leeanne M
authors.initials: LM
authors.lastname: Carey
authors.affiliation: Florey Neuroscience Institutes , Melbourne, VIC , Australia.
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Rewell
authors.affiliation: School of Life and Environmental Sciences, Deakin University , Warrnambool, VIC , Australia.
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Turchini
authors.affiliation: Institute of Sport Exercise and Active Living, Victoria University , Melbourne, VIC , Australia.
authors.forename: Gunveen
authors.initials: G
authors.lastname: Kaur
authors.affiliation: School of Psychological Science, La Trobe University , Melbourne, VIC , Australia.
authors.forename: Sheila G
authors.initials: SG
authors.lastname: Crewther
keywords: middle-cerebral-artery-occlusion; mood; polyunsaturated fatty acids; stroke