title: Calcium-activated chloride channels do not contribute to the odorant transduction current in the marine teleost Isacia conceptionis.
abstract: This study compared the contribution of the Ca²⁺-activated Cl⁻ conductance to the electroolfactogram (EOG) evoked by different odorant classes between the marine Cabinza grunt Isacia conceptionis and rainbow trout Oncorhynchus mykiss. The Ca²⁺-activated Cl⁻ channel blocker niflumic acid significantly diminished odorant responses in O. mykiss, but had no effect on the EOG in I. conceptionis, supporting the notion that Ca²⁺-activated Cl⁻ channels may not operate as odorant transduction current amplifiers in this marine teleost.
authors.affiliation: Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Avda. Gran Bretaña 1111, 2360102, Valparaíso, Chile.
authors.forename: R
authors.initials: R
authors.lastname: Osorio
authors.forename: O
authors.initials: O
authors.lastname: Schmachtenberg
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000502:physiology*; D005260:Female; D008297:Male; D009544:Niflumic Acid / Q000494:pharmacology; D009812:Odorants; D009831:Olfactory Mucosa / Q000502:physiology; D017686:Oncorhynchus mykiss / Q000502:physiology*; D010473:Perciformes / Q000502:physiology*; D012903:Smell / Q000502:physiology*
chemical_list: D018118:Chloride Channels; D009544:Niflumic Acid; D002118:Calcium
keywords: fish; olfaction; olfactory receptor neuron; rainbow trout