title: Diabetes mellitus with pulmonary tuberculosis--a double trouble.
abstract: Diabetic patients are often at a higher risk for developing several types of infections and infection does alter the handling of glucose by tissues. Pulmonary infections in diabetics are characterised by alteration in host defence, in entire body and in the lung locally as well as in the function of respiratory epithelium and ciliary motility. Association between diabetes mellitus and pulmonary tuberculosis is well established, while the prevalence of tuberculosis is increased 4-5 times more among diabetics. Impairment of host defence plays an important role for changing the clinical, radiological and bacteriological presentation in diabetic patients. It is also reported by the various studies that hyperglycaemia favours the growth of tuberculosis bacilli. So the severity of tuberculosis appears more cirtical with the degree of hyperglycaemia and host defence activity. This overlap between the diabetic and tuberculosis epidemics could adversely affect global tuberculosis control efforts.
authors.affiliation: Department of Pulmonary Medicine, CSM Medical University (Erstwhile King George's Medical College), Lucknow 226003.
authors.forename: Surya
authors.initials: S
authors.lastname: Kant
authors.affiliation: Department of Pulmonary Medicine, CSM Medical University (Erstwhile King George's Medical College), Lucknow 226003.
authors.forename: Hem
authors.initials: H
authors.lastname: Lata
authors.affiliation: Department of Pulmonary Medicine, CSM Medical University (Erstwhile King George's Medical College), Lucknow 226003.
authors.forename: S M
authors.initials: SM
authors.lastname: Natu
authors.affiliation: Department of Pulmonary Medicine, CSM Medical University (Erstwhile King George's Medical College), Lucknow 226003.
authors.forename: Arvind Kumar
authors.initials: AK
authors.lastname: Mishra
authors.affiliation: Department of Pulmonary Medicine, CSM Medical University (Erstwhile King George's Medical College), Lucknow 226003.
authors.forename: N S
authors.initials: NS
authors.lastname: Verma
mesh_terms: D003920:Diabetes Mellitus / Q000453:epidemiology*; D014943:Global Health; D006801:Humans; D015995:Prevalence; D012307:Risk Factors; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology*