title: Carotid intimal thickness and plaque predict prevalence and severity of coronary atherosclerosis: a pilot study.
abstract: We determined whether increased carotid intima-media thickness (cIMT) and prevalence of carotid plaque (CP) are predictive of prevalence and severity of coronary atherosclerosis. Consecutive patients (n = 150) with no history of coronary artery disease (CAD), who underwent both carotid ultrasound and computed tomographic coronary angiography, were included in the analysis. The mean cIMT was higher in patients with CAD than in those without CAD (0.76 vs 0.66 mm, P < .003). In a logistic regression analysis, diabetes (P = .03) and CP (P = .02) were associated with significant coronary plaque. Backward selection analysis (after removing nonsignificant variables) showed higher mean cIMT measurement correlated well with prevalence of any coronary plaque (P = .03) and obstructive coronary plaque disease (P = .05), whereas presence of CP was a good predictor of both obstructive (>50% stenosis P = .003) and any coronary plaque (P = .003). In conclusion, CP and cIMT can be useful predictors of prevalence of CAD and its severity.
authors.affiliation: Clinical Imaging and Research Centre, Wellington Hospital, Wellington Place, London, United Kingdom Institute of Cardiovascular Science, University College London, London, United Kingdom dr.anand2812@gmail.com.
authors.forename: Anand
authors.initials: A
authors.lastname: Jeevarethinam
authors.affiliation: Clinical Imaging and Research Centre, Wellington Hospital, Wellington Place, London, United Kingdom.
authors.forename: Shreenidhi
authors.initials: S
authors.lastname: Venuraju
authors.affiliation: Clinical Imaging and Research Centre, Wellington Hospital, Wellington Place, London, United Kingdom.
authors.forename: Michelle
authors.initials: M
authors.lastname: Weymouth
authors.affiliation: Clinical Imaging and Research Centre, Wellington Hospital, Wellington Place, London, United Kingdom.
authors.forename: Satvir
authors.initials: S
authors.lastname: Atwal
authors.affiliation: Clinical Imaging and Research Centre, Wellington Hospital, Wellington Place, London, United Kingdom Imperial College, London, United Kingdom Middlesex University, London, United Kingdom.
authors.forename: Avijit
authors.initials: A
authors.lastname: Lahiri
mesh_terms: D000368:Aged; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D002340:Carotid Artery Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D059168:Carotid Intima-Media Thickness; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008131:London / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010865:Pilot Projects; D058226:Plaque, Atherosclerotic; D011237:Predictive Value of Tests; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
keywords: cardiovascular computed tomography; carotid plaque; coronary atherosclerosis; intima–medial thickness