title: Trying to rationalize total synthesis.
abstract: Total synthesis has been held in high esteem for many decades. In recent years, however, public opinion has turned more and more skeptical. In particular, long and uneventful sequences towards complex yet useless targets are considered a waste of resources and are refused funding. There is only one way to remedy this unpleasant situation: total synthesis must be efficient and present attractive chemistry. This article tries to show some aspects on how this increase in efficiency might be achieved.
authors.affiliation: University of Vienna, Institute of Organic Chemistry, Währingerstrasse 38, 1090 Wien, Austria. johann.mulzer@univie.ac.at.
authors.forename: Johann
authors.initials: J
authors.lastname: Mulzer
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D015394:Molecular Structure
chemical_list: D001688:Biological Products