title: Different profile of serum leptin between early onset and late onset preeclampsia.
abstract: OBJECTIVE
  This study was designed to clarify the role of leptin and adiponectin in preeclampsia (PE) pathogenesis and different subtypes of preeclampsia.
  
  
  METHODS
  This case control study was performed in 45 PE patients and 45 healthy controls matched for age, BMI, and ethnicity. Serum leptin and adiponectin levels were determined by enzyme linked immunosorbent assay (ELISA).
  
  
  RESULTS
  Maternal serum leptin and adiponectin were significantly higher in PE women than controls. Serum leptin was elevated in early onset preeclampsia (EOPE) and late onset preeclampsia (LOPE) compared to controls. Among PE patients, serum leptin was higher in EOPE than LOPE women. However, serum adiponectin was not different between EOPE and LOPE women. The serum leptin was significantly higher in severe PE than mild PE. The serum adiponectin was significantly elevated in severe PE compared to controls. Significant positive correlation was observed between leptin and adiponectin and also between leptin and BMI in controls. Moreover significant positive correlation was observed between adiponectin and BMI in PE patients and controls.
  
  
  CONCLUSIONS
  The present study showed that serum leptin level may play a significant role as a biomarker to differentiate early and late onset PE and also its relation to BMI and severity of disease.
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran ; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Salimi
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran ; Department of Pharmacology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Farajian-Mashhadi
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran ; Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115-111, Iran.
authors.forename: Anoosh
authors.initials: A
authors.lastname: Naghavi
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Mojgan
authors.initials: M
authors.lastname: Mokhtari
authors.affiliation: Department of Biostatistics and Epidemiology, School of Public Health, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran ; Pregnancy Health Research Center, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Shahrakipour
authors.affiliation: Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Mohsen
authors.initials: M
authors.lastname: Saravani
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743175, Iran.
authors.forename: Minoo
authors.initials: M
authors.lastname: Yaghmaei
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood* / Q000473:pathology; D011247:Pregnancy; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D015415:Biomarkers; D020738:Leptin