title: Chimeric plantibody passively protects mice against aerosolized ricin challenge.
abstract: Recent incidents in the United States and abroad have heightened concerns about the use of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for the ability to passively protect mice from a lethal-dose ricin challenge. The most effective antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by injection and inhalation.
authors.affiliation: Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
authors.forename: Erin K
authors.initials: EK
authors.lastname: Sully
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Whaley
authors.forename: Natasha
authors.initials: N
authors.lastname: Bohorova
authors.forename: Ognian
authors.initials: O
authors.lastname: Bohorov
authors.forename: Charles
authors.initials: C
authors.lastname: Goodman
authors.forename: Do H
authors.initials: DH
authors.lastname: Kim
authors.forename: Michael H
authors.initials: MH
authors.lastname: Pauly
authors.forename: Jesus
authors.initials: J
authors.lastname: Velasco
authors.forename: Ernie
authors.initials: E
authors.lastname: Hiatt
authors.forename: Josh
authors.initials: J
authors.lastname: Morton
authors.forename: Kelsi
authors.initials: K
authors.lastname: Swope
authors.forename: Chad J
authors.initials: CJ
authors.lastname: Roy
authors.forename: Larry
authors.initials: L
authors.lastname: Zeitlin
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Mantis
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D057134:Antibodies, Neutralizing / Q000008:administration & dosage; D000992:Antitoxins / Q000008:administration & dosage*; D005260:Female; D007116:Immunization, Passive / Q000379:methods*; D008807:Mice, Inbred BALB C; D046549:Plantibodies / Q000008:administration & dosage*; D011041:Poisoning / Q000517:prevention & control*; D012276:Ricin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D057134:Antibodies, Neutralizing; D000992:Antitoxins; D046549:Plantibodies; D012276:Ricin