title: Photoactive electrospun fibers for inducing cell death.
abstract: A photoactive electrospun material producing reactive oxygen species (ROS) upon light irradiation is reported. The phototoxicity of the generated ROS is spatially restricted to the fiber-tissue interface by conjugation of the photosensitizer to a macromolecule. Photo-triggered ROS is produced on demand and repeatedly. It induces death of mammalian cells growing on the material surface with high spatial resolution.
authors.affiliation: Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
authors.forename: Doris
authors.initials: D
authors.lastname: Gabriel
authors.forename: Tzahi
authors.initials: T
authors.lastname: Cohen-Karni
authors.forename: David
authors.initials: D
authors.lastname: Huang
authors.forename: Homer H
authors.initials: HH
authors.lastname: Chiang
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kohane
mesh_terms: D000818:Animals; D016923:Cell Death / Q000187:drug effects*; D002460:Cell Line; D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods*; D051379:Mice; D041681:NIH 3T3 Cells; D055668:Photochemical Processes; D011091:Polyesters / Q000494:pharmacology; D011107:Polylysine / Q000494:pharmacology; D013050:Spectrometry, Fluorescence
chemical_list: D011091:Polyesters; C016240:polycaprolactone; D011107:Polylysine
keywords: biomedical devices; pheophorbide a; photo-triggered materials; spatiotemporal cell death modulation