title: High oleic/stearic fatty-acid desaturation index in cord plasma from infants of mothers with gestational diabetes.
abstract: OBJECTIVE
  Enhanced fatty-acid desaturation by stearoyl-CoA desaturase enzyme-1 (SCD1) is associated with obesity. This study determined desaturation in the cord plasma of newborns of mothers with and without gestational diabetes (GDM).
  
  
  METHODS
  Newborns of mothers with GDM (n=21) and without (control, n=22) were recruited. Cord plasma fatty-acid desaturation indices (palmitoleic/palmitic, oleic/stearic ratios) were compared, and correlated with anthropometrics and biochemical measures. A subset of very low-density lipoprotein (VLDL) desaturation indices were determined to approximate the liver SCD1 activity.
  
  
  RESULTS
  The total oleic/stearic index was higher in GDM, despite adjustment for cord glucose concentrations. Among GDM and controls, the oleic/stearic index correlated with cord glucose concentrations (rs=0.36, P=0.02). Both palmitoleic/palmitic and oleic/stearic indices correlated with waist circumference (r=0.47, P=0.001; r=0.37, P=0.01). The VLDL oleic/stearic index was higher in GDM.
  
  
  CONCLUSIONS
  The elevated total oleic/stearic index suggests increased lipogenesis in GDM newborns. Factors in addition to glucose supply may influence fetal SCD1 activity.
authors.affiliation: Division of Endocrinology, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Yee
authors.affiliation: Division of Endocrinology, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Mao
authors.affiliation: Department of Obstetrics and Gynecology, Los Angeles Biomedical Research at Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Ross
authors.affiliation: Division of Endocrinology, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: W N P
authors.initials: WN
authors.lastname: Lee
authors.affiliation: Department of Obstetrics and Gynecology, Los Angeles Biomedical Research at Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Desai
authors.affiliation: Department of Obstetrics and Gynecology, Los Angeles Biomedical Research at Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: A
authors.initials: A
authors.lastname: Toda
authors.affiliation: Department of Obstetrics and Gynecology, Los Angeles Biomedical Research at Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Kjos
authors.affiliation: Division of Endocrinology, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Hicks
authors.affiliation: Division of Endocrinology, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Patterson
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000097:blood*; D005229:Fatty Acids, Monounsaturated / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D019301:Oleic Acid / Q000097:blood*; D019308:Palmitic Acid / Q000097:blood; D011247:Pregnancy; D013229:Stearic Acids / Q000097:blood*
chemical_list: D005229:Fatty Acids, Monounsaturated; D013229:Stearic Acids; C008757:palmitoleic acid; D019301:Oleic Acid; D019308:Palmitic Acid; C031183:stearic acid