title: New 5-ylidene rhodanine derivatives based on the dispacamide A model.
abstract: A practical approach for the preparation of (5Z) 5-ylidene rhodanine derivatives bearing the (4,5-dihalogeno-pyrrol-2-yl)carbamoyl fragment of dispacamide A is reported. The new compounds were obtained in good yields (19-88 %) by Knoevenagel condensation according to a solution-phase microwave dielectric heating protocol in the presence of organic bases (piperidine, TEA, and AcONa) from a set of N-substituted rhodanines 2(a-i). The ten synthetic products 3(a-j) have been synthesized with a Z-geometry about their exocyclic double bond and the structure of one of these compounds (3) was confirmed by a single X-ray diffraction analysis. The new (5Z) 5-ylidene rhodanine derivatives 3(a-j) were tested against eight protein kinases.
authors.affiliation: Université de Rennes 1 Institut des Sciences Chimiques de Rennes ISCR UMR CNRS 6226, groupe Ingénierie Chimique et Molécules pour le Vivant (ICMV), Bât. 10 A, Campus de Beaulieu, CS 74205, 263 Avenue du Général Leclerc, 35042,  Rennes Cedex, France.
authors.forename: Solene
authors.initials: S
authors.lastname: Guiheneuf
authors.forename: Ludovic
authors.initials: L
authors.lastname: Paquin
authors.forename: François
authors.initials: F
authors.lastname: Carreaux
authors.forename: Emilie
authors.initials: E
authors.lastname: Durieu
authors.forename: Thierry
authors.initials: T
authors.lastname: Roisnel
authors.forename: Laurent
authors.initials: L
authors.lastname: Meijer
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bazureau
mesh_terms: D060326:Chemistry Techniques, Synthetic; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D047428:Protein Kinase Inhibitors; D011758:Pyrroles; D012236:Rhodanine