title: Non-destructive localization and identification of active pharmaceutical compounds by Raman chemical imaging.
abstract: Raman spectroscopy is a powerful and non-destructive technique for chemical and structural identification. Based on inelastic scattering of laser light by molecular vibrations, the analysis can be localized on a microscopic area when combined with a microscope. Thus, by moving the sample under the microscope objective and recording a Raman spectrum at each point, a map of the intensity of specific Raman bands can be generated, effectively creating a chemical image of the sample at the microscale. Here, we present an application of this technique for identifying and localizing active pharmaceutical ingredients in a polymer matrix.
authors.affiliation: Ecole d'ingénieurs et d'architectes de Fribourg (EIA-FR), Institut des Technologies Chimiques (ChemTech), Boulevard de Pérolles 80, CH-1705 Fribourg, Switzerland.
authors.forename: Pierre
authors.initials: P
authors.lastname: Brodard
authors.forename: Samuel
authors.initials: S
authors.lastname: Roth
authors.forename: Olivier
authors.initials: O
authors.lastname: Vorlet
mesh_terms: D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D004364:Pharmaceutical Preparations