title: Activity of host antimicrobials against multidrug-resistant Acinetobacter baumannii acquiring colistin resistance through loss of lipopolysaccharide.
abstract: Acinetobacter baumannii can acquire resistance to the cationic peptide antibiotic colistin through complete loss of lipopolysaccharide (LPS) expression. The activities of the host cationic antimicrobials LL-37 and human lysozyme against multidrug-resistant clinical isolates of A. baumannii that acquired colistin resistance through lipopolysaccharide loss were characterized. We demonstrate that LL-37 has activity against strains lacking lipopolysaccharide that is similar to that of their colistin-sensitive parent strains, whereas human lysozyme has increased activity against colistin-resistant strains lacking LPS.
authors.affiliation: Biomedical Institute of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Seville, Seville, Spain.
authors.forename: Meritxell
authors.initials: M
authors.lastname: García-Quintanilla
authors.forename: Marina R
authors.initials: MR
authors.lastname: Pulido
authors.forename: Patricia
authors.initials: P
authors.lastname: Moreno-Martínez
authors.forename: Reyes
authors.initials: R
authors.lastname: Martín-Peña
authors.forename: Rafael
authors.initials: R
authors.lastname: López-Rojas
authors.forename: Jerónimo
authors.initials: J
authors.lastname: Pachón
authors.forename: Michael J
authors.initials: MJ
authors.lastname: McConnell
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000378:metabolism*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D008070:Lipopolysaccharides / Q000378:metabolism*; D008826:Microbial Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D008070:Lipopolysaccharides; D003091:Colistin