title: [Morphological peculiarities of the synovial membrane of human knee joint in mature age].
abstract: The structural and functional reorganization of the synovial membrane of the knee joint capsule was studied in 22 individuals of mature age (30-65 years) of both genders with the use of light and electron microscopy, histochemistry, immunohistochemistry and morphometry. The morpho-functional peculiarities of the synovial membrane remodeling in the II period of mature age included: increase the in the synovial intima thickness; significant accumulation of type IV collagen at the border of synovial intima with the subintimal fibrovascular layer of synovial membrane; activation of matrix metalloproteinases MMP-2 and MMP-9; increased cell proapoptotic activity in synovial intima. Collectively, these changes may initiate the disturbances in fluid production and the development of the degenerative-dystrophic processes in the articular cartilage at this stage of ontogenesis.
authors.forename: T G
authors.initials: TG
authors.lastname: Kozhanova
authors.forename: V S
authors.initials: VS
authors.lastname: Poliakova
authors.forename: E E
authors.initials: EE
authors.lastname: Mkhitarian
authors.forename: K N
authors.initials: KN
authors.lastname: Meshcheriakov
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D001344:Autopsy; D003094:Collagen / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007719:Knee Joint / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D008854:Microscopy, Electron; D008875:Middle Aged; D013583:Synovial Membrane / Q000378:metabolism / Q000648:ultrastructure*; D055815:Young Adult
chemical_list: D003094:Collagen; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9