title: Immune and inflammatory pathways in NASH.
abstract: Immune and inflammatory pathways have a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Both the innate and adaptive immune systems contribute to the development of NAFLD. Pathogen-associated molecular patterns and danger-associated molecular patterns are known to activate a variety of pattern-recognition receptors that result in inflammation. The key features of the immune system and inflammatory pathways in the development of NAFLD are discussed in this review.
authors.affiliation: Department of Medicine, University of Massachusetts Medical School, LRB208, 364 Plantation Street, Worcester, MA 01605 USA.
authors.forename: Michal
authors.initials: M
authors.lastname: Ganz
authors.affiliation: Department of Medicine, University of Massachusetts Medical School, LRB208, 364 Plantation Street, Worcester, MA 01605 USA.
authors.forename: Gyongyi
authors.initials: G
authors.lastname: Szabo
keywords: DAMPs; Immunity; Inflammation; NAFLD; NASH; PAMPs