title: A new sesquiterpenoid from Scaphium macropodum (Miq.) Beumee.
abstract: A new sesquiterpenoid, malayscaphiol (1), and three known compounds, lupeol (2), lupenone (3) and stigmasterol (4), were isolated from the methanolic extract of the stem bark of Scaphium macropodum. The structures of the isolated compounds were determined using several spectroscopic methods, including UV-vis, FT-IR, 1D and 2D NMR, and mass spectrometer. Major isolated compounds were assayed for cytotoxicity and anti-acetylcholinesterase activities. The chemotaxonomy significance of this plant was also discussed.
authors.affiliation: a Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM) , 40450 Shah Alam , Selangor , Malaysia.
authors.forename: L M Ramadhan
authors.initials: LM
authors.lastname: Al Muqarrabun
authors.forename: Norizan
authors.initials: N
authors.lastname: Ahmat
authors.forename: S Ruzaina S
authors.initials: SR
authors.lastname: Aris
authors.forename: Nurdiana
authors.initials: N
authors.lastname: Shamsulrijal
authors.forename: Syarul N
authors.initials: SN
authors.lastname: Baharum
authors.forename: Rafidah
authors.initials: R
authors.lastname: Ahmad
authors.forename: A Rifki
authors.initials: AR
authors.lastname: Rosandy
authors.forename: M Nazip
authors.initials: MN
authors.lastname: Suratman
authors.forename: H
authors.initials: H
authors.lastname: Takayama
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D008296:Malaysia; D019660:Malvaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D024301:Plant Bark / Q000737:chemistry; D011083:Polycyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013265:Stigmasterol / Q000737:chemistry / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification; D000094042:Lupanes
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D053978:Pentacyclic Triterpenes; D011083:Polycyclic Compounds; D012717:Sesquiterpenes; D013265:Stigmasterol; D014315:Triterpenes; C470592:lupenone; D000094042:Lupanes; C000591682:malayscaphiol; C010480:lupeol
keywords: Scaphium macropodum; Sterculiaceae; anti-acetylcholinesterase; cytotoxicity; malayscaphiol; sesquiterpenoid