title: Polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS), a heterogeneous and chronic condition, today affects about 5% of women of reproductive age. PCOS is strongly associated with states of insulin resistance and hyperinsulinemia. Risk factors include genetics, metabolic profiles, and the in utero environment. Long-term consequences of PCOS include metabolic complications such as diabetes, obesity, and cardiovascular disease. Dysregulation of insulin action is closely linked to the pathogenesis of PCOS. However, whether insulin resistance is the causative factor in the development of PCOS remains to be ascertained. Moreover, the mechanism by which insulin resistance may lead to reproductive dysfunction requires further elucidation.
authors.affiliation: Division of Endocrinology and Metabolism, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY 10003, USA.
authors.forename: Anindita
authors.initials: A
authors.lastname: Nandi
authors.affiliation: Division of Endocrinology and Metabolism, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY 10003, USA.
authors.forename: Zijian
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Division of Endocrinology and Metabolism, Beth Israel Medical Center, Albert Einstein College of Medicine, New York, NY 10003, USA.
authors.forename: Ronak
authors.initials: R
authors.lastname: Patel
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Gerald J. Friedman Diabetes Institute, Beth Israel Medical Center, Albert Einstein College of Medicine, 317 East 17th Street, 7th Floor, New York, NY 10003, USA. Electronic address: lporetsk@chpnet.org.
authors.forename: Leonid
authors.initials: L
authors.lastname: Poretsky
mesh_terms: D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000209:etiology / Q000378:metabolism / Q000628:therapy
keywords: Insulin resistance; Long-term effects; Polycystic ovary syndrome; Risk factors