title: Safety and effectiveness of large gel particle hyaluronic acid with lidocaine for correction of midface volume loss.
abstract: BACKGROUND
  Midface volume loss and contour deficiency are often treated using soft-tissue fillers capable of elevating and supporting facial features.
  
  
  OBJECTIVE
  To evaluate the effectiveness and safety of large gel particle hyaluronic acid with 0.3% lidocaine (LGP-HA-L) for the treatment of midface volume loss or contour deficiency.
  
  
  METHODS
  This 24-week, open-label study recruited adults aged 18 to 65 with bilateral moderate to substantial midface volume loss or contour deficiency (Medicis Midface Volume Scale (MMVS) score 3-4). The primary effectiveness measure was MMVS response (≥1-grade improvement) 8 weeks after treatment according to evaluators blinded to injection volume.
  
  
  RESULTS
  All enrolled patients (n = 40; 85.0% female; mean ± SD age 53.1 ± 7.0 years) completed the study. Mean ± SD injected volume for both sides of the midface was 5.3 ± 2.5 mL. Week 8 MMVS response rates were 97.5% according to blinded evaluators and treating investigators and 90.0% according to patients; week 24 rates were 90.0%, 92.5%, and 82.5%, respectively. Global Aesthetic Improvement Scale response rates were 95.0% to 100.0% throughout the study. Adverse events were reported in 60.0% of patients and were mild or moderate; all resolved by study end and most within 1 week.
  
  
  CONCLUSIONS
  Midface volume loss or contour deficiency may be safely and effectively corrected using LGP-HA-L.
authors.affiliation: Division of Dermatology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Vince
authors.initials: V
authors.lastname: Bertucci
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Lin
authors.forename: Robert A
authors.initials: RA
authors.lastname: Axford-Gatley
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Theisen
authors.forename: Arthur
authors.initials: A
authors.lastname: Swift
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D003357:Cosmetic Techniques; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005145:Face; D005260:Female; D005782:Gels; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007267:Injections; D008297:Male; D008875:Middle Aged; D010316:Particle Size; D016037:Single-Blind Method; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; D003879:Dermatologic Agents; D005782:Gels; D006820:Hyaluronic Acid