title: Investigation on the synthesis of 25-hydroxycholesterol.
abstract: A very efficient and environmentally benign method has been developed for the synthesis of 25-hydroxycholesterol. The reaction was performed in THF-water (4:1, v/v) using NBS as the brominating agent, followed by the easy reduction of C-Br with lithium aluminum hydride in THF, to yield the final product corresponding to a Markovnikov's rule. Excellent yields and regioselectivity have been obtained.
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhao
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Ji
authors.affiliation: Zhejiang Garden Biochemical High-tech. Co., Ltd, Hangzhou 310018, PR China.
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Qian
authors.affiliation: Zhejiang Garden Biochemical High-tech. Co., Ltd, Hangzhou 310018, PR China.
authors.forename: Jian-Gang
authors.initials: JG
authors.lastname: Liu
authors.affiliation: Zhejiang Garden Biochemical High-tech. Co., Ltd, Hangzhou 310018, PR China.
authors.forename: Zi-Qiang
authors.initials: ZQ
authors.lastname: Wang
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, PR China.
authors.forename: Wan-Feng
authors.initials: WF
authors.lastname: Yu
authors.affiliation: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, PR China. Electronic address: chemtec@163.com.
authors.forename: Xin-Zhi
authors.initials: XZ
authors.lastname: Chen
mesh_terms: D002384:Catalysis; D002762:Cholecalciferol / Q000138:chemical synthesis* / Q000737:chemistry; D003897:Desmosterol / Q000138:chemical synthesis* / Q000737:chemistry; D006888:Hydroxycholesterols / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D006888:Hydroxycholesterols; D002762:Cholecalciferol; D003897:Desmosterol; C007997:25-hydroxycholesterol
keywords: 25-Hydroxycholesterol; Bromohydrin; Desmosterol; Reduction