title: Resting state executive control network adaptations in amnestic mild cognitive impairment.
abstract: Executive dysfunction is frequently associated with episodic memory decline in amnestic mild cognitive impairment (aMCI) patients. Resting state executive control network (RS-ECN) represents a novel approach to interrogate the integrity of brain areas underlying executive dysfunction. The present study aims to investigate RS-ECN in aMCI and examine a possible link between changes in brain functional connectivity and declines in executive function. aMCI individuals (n = 13) and healthy subjects (n = 16) underwent cognitive assessment including executive function and high field functional magnetic resonance imaging. Individual RS-ECN maps were estimated using a seed-based cross-correlation method. Between groups RS-ECN functional connectivity comparison was assessed using voxel-wise statistic parametric mapping. aMCI individuals had reduced RS-ECN connectivity in the anterior cingulate cortex (ACC) and dorsal lateral prefrontal cortex (DLPFC), bilaterally. In contrast, aMCI showed increased connectivity in ventral lateral and anterior prefrontal cortex, bilaterally. Connectivity strength was associated with executive function in the ACC (r = 0.6213, p = 0.023) and right DLPFC (r = 0.6454, p = 0.017). Coexistence between connectivity declines and recruitment of brain regions outside the RS-ECN as reported here fits a brain reserve conceptual framework in which brain networks undergo remodeling in aMCI individuals.
authors.affiliation: Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, Canada Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Liyong
authors.initials: L
authors.lastname: Wu
authors.affiliation: Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, Canada McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada.
authors.forename: Ricardo Bernardi
authors.initials: RB
authors.lastname: Soder
authors.affiliation: Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, Canada.
authors.forename: Dorothée
authors.initials: D
authors.lastname: Schoemaker
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada.
authors.forename: Felix
authors.initials: F
authors.lastname: Carbonnell
authors.affiliation: Department of Psychology, Neuropsychology Unit, McGill University, Montreal, QC, Canada.
authors.forename: Viviane
authors.initials: V
authors.lastname: Sziklas
authors.affiliation: Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, Canada.
authors.forename: Jared
authors.initials: J
authors.lastname: Rowley
authors.affiliation: Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, Canada.
authors.forename: Sara
authors.initials: S
authors.lastname: Mohades
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada.
authors.forename: Vladmir
authors.initials: V
authors.lastname: Fonov
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada.
authors.forename: Pierre
authors.initials: P
authors.lastname: Bellec
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada.
authors.forename: Alain
authors.initials: A
authors.lastname: Dagher
authors.affiliation: McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada.
authors.forename: Amir
authors.initials: A
authors.lastname: Shmuel
authors.affiliation: Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
authors.forename: Jianping
authors.initials: J
authors.lastname: Jia
authors.affiliation: McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, Canada.
authors.forename: Serge
authors.initials: S
authors.lastname: Gauthier
authors.affiliation: Translational Neuroimaging Laboratory, Douglas Hospital, McGill University, Montreal, QC, Canada McGill Centre for Studies in Aging (MCSA), McGill University, Montreal, QC, Canada McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, QC, Canada.
authors.forename: Pedro
authors.initials: P
authors.lastname: Rosa-Neto
mesh_terms: D000368:Aged; D000647:Amnesia / Q000150:complications; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology; D060825:Cognitive Dysfunction / Q000209:etiology / Q000473:pathology*; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009415:Nerve Net / Q000098:blood supply*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D012146:Rest
chemical_list: D010100:Oxygen
keywords: Executive control network; executive function; functional MRI; mild cognitive impairment; neural plasticity