title: [Relationship between female dyslipidemia and polymorphism of suppressor of cytokine signaling-3 in Xinjiang Uygur population].
abstract: OBJECTIVE
  To explore whether the polymorphism of suppressor of cytokine signaling-3 (SOCS-3) and dyslipidemia are correlated in Uygur females.
  
  
  METHODS
  A total of 1379 Uygur females from Xinjiang Uygur Autonomous Region were enrolled in this study. Three single nucleotide polymorphisms (SNPs), namely rs12953258, rs4969168, and rs9914220, were analyzed after being genotyped.
  
  
  RESULTS
  Of these three SNPs, the frequency distribution of rs12953258 sites was found to be significantly different between dyslipidemia group and normal group (P=0.032). The frequency distribution of rs12953258 sites between the high-density lipoprotein-cholesterol (HDL-C) abnormal group and normal group also showed significant difference (P=0.029). Logistic regression analysis showed that the genotype AA of rs12953258 was a risk factor for dyslipidemia among the Uygur females [CC vs. AA:OR=3.271,95%CI(1.092-9.797), P=0.034]. The genotype AA of rs12953258 might be related to the decreased high HDL-C and increased trigleceride, whereas the genotype AA coupled with abnormal body mass index (BMI) were more likely to be linked with the higher prevalence of dyslipidemia in Uygur females.
  
  
  CONCLUSIONS
  The polymorphism of SOCS-3 is correlated to the dyslipidemia in Uygur females in Xinjiang. Carriers of Genotype AA of rs12953258 coupled with abnormal BMI are more susceptible to dyslipidemia.
authors.affiliation: Department of Clinical Medicine, Medical College of Shihezi University, Shihezi, Xinjiang 832000, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Meng
authors.affiliation: Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang, Urumuqi 830001, China.
authors.forename: Nan-fang
authors.initials: NF
authors.lastname: Li
authors.affiliation: Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang, Urumuqi 830001, China.
authors.forename: Xiao-guang
authors.initials: XG
authors.lastname: Yao
authors.affiliation: Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang, Urumuqi 830001, China.
authors.forename: Liang
authors.initials: L
authors.lastname: Shao
authors.affiliation: Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang, Urumuqi 830001, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.affiliation: Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang, Urumuqi 830001, China.
authors.forename: Abdurmy
authors.initials: A
authors.lastname: Arikin
authors.affiliation: Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region, Hypertension Institute of Xinjiang, Urumuqi 830001, China.
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D050171:Dyslipidemias / Q000208:ethnology / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*
chemical_list: C106644:SOCS3 protein, human; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins