title: Multiple ischemic strokes caused by nonbacterial thrombotic endocarditis because of gallbladder cancer: a case report.
abstract: We report a case of a 62-year-old woman with multiple ischemic strokes caused by nonbacterial thrombotic endocarditis (NBTE) because of gallbladder cancer. Transesophageal echocardiography showed NBTE on the mitral valve. The NBTE disappeared with anticoagulation treatment for 2 weeks. Abdominal computed tomography showed a gallbladder tumor that was surgically resected. Histopathologic studies showed poorly differentiated tumor cells and the production of mucin. Trousseau syndrome with gallbladder cancer is very rare. We suggest that the development of NBTE is related to the production of mucin.
authors.affiliation: Department of Neurosurgery, Yamaguchi University Hospital, Yamaguchi, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Yamane
authors.affiliation: Department of Neurosurgery, Yamaguchi University Hospital, Yamaguchi, Japan. Electronic address: sadapiro@yamaguchi-u.ac.jp.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Sadahiro
authors.affiliation: Department of Neurosurgery, Yamaguchi University Hospital, Yamaguchi, Japan.
authors.forename: Hisaharu
authors.initials: H
authors.lastname: Goto
authors.affiliation: Department of Neurosurgery, Yamaguchi University Hospital, Yamaguchi, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Inamura
authors.affiliation: Department of Neurosurgery, Yamaguchi University Hospital, Yamaguchi, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Ishihara
authors.affiliation: Department of Neurosurgery, Yamaguchi University Hospital, Yamaguchi, Japan.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Oka
authors.affiliation: Department of Neurosurgery, Yamaguchi University Hospital, Yamaguchi, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Oku
authors.affiliation: Department of Pathology, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kondo
authors.affiliation: Department of Neurosurgery, Yamaguchi University Hospital, Yamaguchi, Japan.
authors.forename: Michiyasu
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D002545:Brain Ischemia / Q000209:etiology*; D004696:Endocarditis / Q000150:complications*; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D020521:Stroke / Q000209:etiology*
keywords: Nonbacterial thrombotic endocarditis; Trousseau syndrome; anticoagulation; gallbladder cancer; transesophageal echocardiography