title: AMPK: regulating energy balance at the cellular and whole body levels.
abstract: AMP-activated protein kinase appears to have evolved in single-celled eukaryotes as an adenine nucleotide sensor that maintains energy homeostasis at the cellular level. However, during evolution of more complex multicellular organisms, the system has adapted to interact with hormones so that it also plays a key role in balancing energy intake and expenditure at the whole body level.
authors.affiliation: Division of Cell Signalling & Immunology, College of Life Sciences, and Division of Cardiovascular and Diabetes Medicine, College of Medicine, Dentistry & Nursing, University of Dundee, Dundee, Scotland, United Kingdom.
authors.forename: D Grahame
authors.initials: DG
authors.lastname: Hardie
authors.forename: Michael L J
authors.initials: ML
authors.lastname: Ashford
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology*; D006728:Hormones / Q000378:metabolism; D006801:Humans
chemical_list: D006728:Hormones; D000255:Adenosine Triphosphate; D055372:AMP-Activated Protein Kinases; D002118:Calcium