title: Left ventricular restoration devices.
abstract: Left ventricular (LV) remodeling results in continuous cardiac chamber enlargement and contractile dysfunction, perpetuating the syndrome of heart failure. With current exhaustion of the neurohormonal medical paradigm, surgical and device-based therapies have been increasingly investigated as a way to restore LV chamber architecture and function. Left ventricular restoration has been attempted with surgical procedures, such as partial left ventriculectomy, surgical ventricular restoration with or without revascularization, and devices, such as the Acorn CorCap, the Paracor HeartNet, and the Myocor Myosplint. Whereas all these techniques require surgical access, with or without cardiopulmonary bypass, a newer ventricular partitioning device (VPD) called Parachute, can be delivered percutaneously through the aortic valve. Designed to achieve LV restoration from within the ventricle, this VPD partitions the LV by isolating aneurysmal from normal myocardium thereby diminishing the functioning cavity. This review aims to critically appraise the above methods, with particular attention to device-based therapies.
authors.affiliation: Department of Medicine, Division of Cardiovascular Medicine, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA, guilherme.oliveira@uhhospitals.org.
authors.forename: Guilherme H
authors.initials: GH
authors.lastname: Oliveira
authors.forename: Sadeer G
authors.initials: SG
authors.lastname: Al-Kindi
authors.forename: Hiram G
authors.initials: HG
authors.lastname: Bezerra
authors.forename: Marco A
authors.initials: MA
authors.lastname: Costa
mesh_terms: D001026:Coronary Artery Bypass; D006333:Heart Failure / Q000601:surgery*; D006353:Heart-Assist Devices; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000601:surgery*; D019919:Prosthesis Implantation; D013526:Surgical Mesh; D020257:Ventricular Remodeling