title: Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients.
abstract: BACKGROUND
  Tumor Associated Antigens are characterized by spontaneous immune response in cancer patients as a consequence of overexpression and epitope-presentation on MHC class I/II machinery. Matrix Metalloprotease 11 (MMP11) expression has been associated with poor prognosis for several cancer types, including breast and prostate cancer.
  
  
  METHODS
  MMP11 expression was determined by immunoistochemistry in breast and prostate cancer samples. Circulating MMP11 protein as well as the spontaneous immune responses against MMP11 were analyzed in a set of breast and prostate cancer patients.
  
  
  RESULTS
  In plasma samples MMP11 protein was present in 5/13 breast cancer patients and in 1/12 prostate cancer patients. An antibody response was observed in 7/13 breast cancer patients and in 3/12 prostate cancer patients.
  
  
  CONCLUSIONS
  These findings further suggest MMP11 as a promising biomarker for these tumor types and a suitable target for cancer immunotherapy strategies.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Roscilli
authors.forename: Manuela
authors.initials: M
authors.lastname: Cappelletti
authors.forename: Claudia
authors.initials: C
authors.lastname: De Vitis
authors.forename: Gennaro
authors.initials: G
authors.lastname: Ciliberto
authors.forename: Arianna
authors.initials: A
authors.lastname: Di Napoli
authors.forename: Luigi
authors.initials: L
authors.lastname: Ruco
authors.forename: Rita
authors.initials: R
authors.lastname: Mancini
authors.affiliation: Takis, Rome, 00128, Italy. luigi.aurisicchio@gmail.com.
authors.forename: Luigi
authors.initials: L
authors.lastname: Aurisicchio
mesh_terms: D000912:Antibodies, Neoplasm / Q000097:blood*; D000917:Antibody Formation / Q000276:immunology*; D001943:Breast Neoplasms / Q000097:blood / Q000201:enzymology* / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D053507:Matrix Metalloproteinase 11 / Q000097:blood* / Q000276:immunology; D009361:Neoplasm Invasiveness; D011471:Prostatic Neoplasms / Q000097:blood / Q000201:enzymology* / Q000276:immunology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000912:Antibodies, Neoplasm; C511771:MMP11 protein, human; D053507:Matrix Metalloproteinase 11