title: Effect of Ramadan fasting on serum concentration of apelin-13 and new obesity indices in healthy adult men.
abstract: BACKGROUND
  The aim of this study was to determine how Ramadan fasting (RF) affected the recently described new obesity indices [visceral adiposity index (VAI), waist circumference to height ratio (WHtR), body adiposity index (BAI)], and serum concentration of apelin-13 (RF) in healthy adult men.
  
  
  METHODS
  For this purpose, 42 healthy adult men were selected. Anthropometric parameters were measured and a sample of venous blood was obtained for biochemical assays on the first and last days of Ramadan. When all subjects were evaluated, all anthropometric parameters changed except VAI. Serum apelin-13, triglyceride (TG), HDL-cholesterol (HDL-C), and insulin levels did not change. When patients were divided into 3 groups according to body mass index (BMI), BAI decreased in normal-weight subjects and WHtR decreased in other groups, but VAI and apelin-13 did not change in any groups.
  
  
  RESULTS
  We demonstrate for the first time that while some anthropometric parameters changed, VAI and serum apelin-13 levels did not change with RF. BMI, waist circumference (WC), TG, and HDL-C were evaluated together in calculation of VAI. TG, VAI, and HDL-C remained unchanged by RF. Even if body weight (BW) and BMI decreased, apelin-13 was not affected by RF. The data on serum apelin-13 may have been influenced by the small-percentage decrease in BW, as well as insignificant improvements in metabolic parameters such as lipid profiles, glucose, and insulin.
  
  
  CONCLUSIONS
  We found that Ramadan fasting in healthy adult men was associated with significant decreases in BW, BMI, WHtR, and BAI, but we found no significant changes in VAI and serum apelin-13 concentrations.
authors.affiliation: Department of Medical Biochemistry, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Celik
authors.affiliation: Department of Biochemistry Laboratory, Dr. Ersin Arslan State Hospital, Gaziantep, Turkey.
authors.forename: Edibe
authors.initials: E
authors.lastname: Saricicek
authors.affiliation: Department of Anesthesiology and Reanimation, Gaziantep University, Gaziantep, Turkey.
authors.forename: Vahap
authors.initials: V
authors.lastname: Saricicek
authors.affiliation: Department of Eye Diseases, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Sahin
authors.affiliation: Department of Medical Biochemistry, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ozdemir
authors.affiliation: Department of Emergency Medicine, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Bozkurt
authors.affiliation: Department of Emergency Medicine, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Okumus
authors.affiliation: Department of Family Medicine, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Mustafa Haki
authors.initials: MH
authors.lastname: Sucakli
authors.affiliation: Department of Biochemistry Laboratory, Necip Fazil City Hospital, Kahramanmaras, Turkey.
authors.forename: Gurkan
authors.initials: G
authors.lastname: Cikim
authors.affiliation: Department of Nephrology, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Coskun
authors.affiliation: Department of Internal Medicine, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Mustafa Saygin
authors.initials: MS
authors.lastname: Deniz
authors.affiliation: Department of Nephrology, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Ekrem
authors.initials: E
authors.lastname: Dogan
authors.affiliation: Department of Medical Biochemistry, Sutcu Imam University, Medical Faculty, Kahramanmaras, Turkey.
authors.forename: Metin
authors.initials: M
authors.lastname: Kilinc
mesh_terms: D050154:Adiposity / Q000502:physiology*; D000328:Adult; D000073861:Apelin; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D005215:Fasting / Q000097:blood*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood*; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D007514:Islam; D008297:Male; D014421:Turkey; D065927:Waist-Height Ratio
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D008076:Cholesterol, HDL; D036341:Intercellular Signaling Peptides and Proteins