title: Pd-catalyzed decarboxylative cross-coupling of 2-carboxyazine N-oxides with various (hetero)aryl halides.
abstract: Decarboxylative cross-coupling reactions of substituted 2-carboxyazine N-oxides, with a variety of (hetero)aryl halides, by bimetallic Pd(0)/Cu(I) and Pd(0)/Ag(I) catalysis are reported. Two possible pathways, a conventional bimetallic-catalyzed decarboxylative arylation, as well as a protodecarboxylative/direct C-H arylation sequence have been considered. These methods provide the first general decarboxylative arylation methodology for the 2-carboxyazine series.
authors.affiliation: Normandie University, COBRA, UMR 6014 et FR 3038, University Rouen; INSA Rouen; CNRS, IRCOF, 1 rue Tesnière 76821 Mont-Saint-Aignan Cedex (France).
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Rouchet
authors.forename: Cédric
authors.initials: C
authors.lastname: Schneider
authors.forename: Cédric
authors.initials: C
authors.lastname: Spitz
authors.forename: Johan
authors.initials: J
authors.lastname: Lefèvre
authors.forename: George
authors.initials: G
authors.lastname: Dupas
authors.forename: Corinne
authors.initials: C
authors.lastname: Fruit
authors.forename: Christophe
authors.initials: C
authors.lastname: Hoarau
keywords: 2-carboxyazine N-oxides; catalysis; cross-coupling; palladium