title: Absolute configuration determination using enantiomeric pairs of molecularly imprinted polymers.
abstract: A new method for determination of absolute configuration (AC) is demonstrated using an enantiomeric pair of molecularly imprinted polymers, referred to as "DuoMIPs". The ratio of HPLC capacity factors (k') for the analyte on each of the DuoMIPs is defined as the γ factor and can be used to determine AC when above 1.2. A mnemonic based on the complementary binding geometry of the DuoMIPs was used to aid in understanding and prediction of AC.
authors.affiliation: Department of Chemistry, 232 Choppin Hall, Louisiana State University , Baton Rouge, Louisiana 70803, United States.
authors.forename: Danielle S
authors.initials: DS
authors.lastname: Meador
authors.forename: David A
authors.initials: DA
authors.lastname: Spivak