title: Complete nucleotide sequences of two blaKPC-2-bearing IncN Plasmids isolated from sequence type 442 Klebsiella pneumoniae clinical strains four years apart.
abstract: We sequenced the oldest blaKPC-2-bearing plasmid isolated in Brazil and another plasmid also carried by a Klebsiella pneumoniae strain of sequence type 442 (ST442), isolated 52 months later. Both plasmids present an IncN backbone and few acquired regions. Because the 2005 plasmid presented deletions and a truncated gene within Tn4401b compared to the 2009 plasmid, we can thus infer that IncN blaKPC-2-bearing plasmids pFCF1305 and pFCF3SP had a common ancestor circulating in Brazil prior to May 2005.
authors.affiliation: Centro de Inovações Tecnológicas do Instituto Evandro Chagas/SVS/Ministério da Saúde, Ananindeua, Pará, Brazil.
authors.forename: Paula Juliana
authors.initials: PJ
authors.lastname: Pérez-Chaparro
authors.forename: Louise Teixeira
authors.initials: LT
authors.lastname: Cerdeira
authors.forename: Maíse Gomes
authors.initials: MG
authors.lastname: Queiroz
authors.forename: Clayton Pereira Silva
authors.initials: CP
authors.lastname: de Lima
authors.forename: Carlos Emílio
authors.initials: CE
authors.lastname: Levy
authors.forename: Mónica
authors.initials: M
authors.lastname: Pavez
authors.forename: Nilton
authors.initials: N
authors.lastname: Lincopan
authors.forename: Evonnildo Costa
authors.initials: EC
authors.lastname: Gonçalves
authors.forename: Elsa Masae
authors.initials: EM
authors.lastname: Mamizuka
authors.forename: Jorge Luiz Mello
authors.initials: JL
authors.lastname: Sampaio
authors.forename: Marcio Roberto Teixeira
authors.initials: MR
authors.lastname: Nunes
authors.forename: John Anthony
authors.initials: JA
authors.lastname: McCulloch
mesh_terms: D001938:Brazil; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000201:enzymology* / Q000235:genetics*; D010957:Plasmids / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D001618:beta-Lactamases