title: [Research progress in heritable dyslipidemia].
abstract: Dyslipidemia is defined as high levels of serum cholesterol and/or triglycerides. Dyslipidemia often leads to severe cardiovascular diseases including coronary heart disease and stroke as the first clinical manifestation, thus threatening the health of human beings. Dyslipidemia diseases can be caused by the genetic factors, including the Mandelian or polygenic inheritance. Traditional methods of identifying genes associated with dyslipidemia are mainly DNA sequencing and linkage analysis, suitable for Mendelian genetic dyslipidemia disease. The rise of next-generation sequencing technology applies to not only Mandelian inheritance, but also complex forms of dyslipidemia diseases. Since 2006, genome-wide association studies (GWAS) screened out many causative genes associated with dyslipidemia, and most of these genes were the previously identified ones by the pedigree-based classic approaches. Furthermore, GWAS revealed that there were the different frequencies of gene variations related to complex forms of dyslipidemia diseases. Most of the identified single nucleotide polymorphisms (SNPs) associated with dyslipidemia are located in non-coding regions and thus people gradually focus on the gene variations of these loci. The identification of the causative genes will provide new insights into the pathophysiology of dyslipidemia diseases and a step toward therapeutic intervention. This review summarized recent pro-gress in heritable dyslipidemia.
authors.affiliation: Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou 325035, China. hyq3375@163.com
authors.forename: Yi-Qun
authors.initials: YQ
authors.lastname: He
authors.affiliation: Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Mei-Fen
authors.initials: MF
authors.lastname: Xu
authors.affiliation: Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Han
authors.initials: H
authors.lastname: Yu
authors.affiliation: Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Geng
authors.affiliation: Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Su-Xue
authors.initials: SX
authors.lastname: Shi
authors.affiliation: Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Xue
authors.affiliation: Emergercy Medical Department, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
authors.forename: Zhong-Qiu
authors.initials: ZQ
authors.lastname: Lu
authors.affiliation: Attardi Institute of Mitochondrial Biomedicine, Wenzhou Medical College, Wenzhou 325035, China.
authors.forename: Min-Xin
authors.initials: MX
authors.lastname: Guan
mesh_terms: D050171:Dyslipidemias / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D020412:Multifactorial Inheritance; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA