title: Nephroprotective effects of Feijoa Sellowiana leaves extract on renal injury induced by acute dose of ecstasy (MDMA) in mice.
abstract: OBJECTIVE
  Because of the high total phenolic contents of Feijoa sellowiana, its nephroprotective effect was determined in 3,4-methylene dioxymethamphetamine (MDMA) treated mice.
  
  
  METHODS
  Animals received 10, 20 and 40 mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (20 mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used. Results : Both extracts at 40 mg/kg resulted in a significant reversal in the raised serum creatinine levels (P <0.05). Not statistically significant was observed in effect of two extracts (P>0.05). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P<0.001 compared to MDMA group). Methanol extract showed higher protective activity in histopathology study.
  
  
  CONCLUSIONS
  F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice.
authors.affiliation: Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mohammad
authors.initials: M
authors.lastname: Karami
authors.affiliation: Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Faezeh
authors.initials: F
authors.lastname: Karimian Nokabadi
authors.affiliation: Department of Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Ebrahimzadeh
authors.affiliation: Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: Farshad
authors.initials: F
authors.lastname: Naghshvar
keywords: Ecstasy; Feijoa sellowiana; Kidney glutathione; MDMA; Nephrotoxicity