title: Low dietary sodium in diabetes nephropathy.
abstract: In a meta-analysis that investigated the effects of dietary sodium restriction in diabetes nephropathy, although blood pressure fell, there were significant increases in plasma renin and aldosterone levels. In this article, we hypothesise that in diabetic nephropathy, ACE-I or ARB treatment attenuates any rise in RAS hormones that might result from dietary salt restriction and that the beneficial effects of the salt restriction such as a lower blood pressure outweigh any potentially negative consequences of RAS activation such as a rise in intraglomerular pressure because of the synergistic effects of sodium restriction and RAS antagonist therapy.
authors.affiliation: Department of Diabetes & Endocrinology, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, United Kingdom. Electronic address: iseetho@liv.ac.uk.
authors.forename: Ian W
authors.initials: IW
authors.lastname: Seetho
authors.affiliation: Department of Diabetes & Endocrinology, St Helens & Knowsley Teaching Hospitals NHS Trust, Marshalls Cross Road, St Helens WA9 3DA, United Kingdom.
authors.forename: Sarah V
authors.initials: SV
authors.lastname: O'Brien
authors.affiliation: Department of Diabetes & Endocrinology, St Helens & Knowsley Teaching Hospitals NHS Trust, Marshalls Cross Road, St Helens WA9 3DA, United Kingdom.
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Hardy
mesh_terms: D003928:Diabetic Nephropathies / Q000209:etiology*; D006801:Humans; D008962:Models, Theoretical; D012084:Renin-Angiotensin System / Q000187:drug effects; D012982:Sodium, Dietary / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D012982:Sodium, Dietary