title: Peri-ictal broadband electrocorticographic activities between 1 and 700 Hz and seizure onset zones in 18 patients.
abstract: OBJECTIVE
  We investigated the relationship between locations of broadband peri-ictal electrocorticographic activities determined by a semi-automatic detection method and seizure onset zones in medically intractable epilepsy patients.
  
  
  METHODS
  We included 18 patients. Peri-ictal periods (-15 to +5s from the ictal onset) were divided into 4 periods of 5s duration each in bandwidth from 1 to 700 Hz divided into 11 bins. Thereafter, we calculated the mean overlapping percentage of the maximum amplitude activity electrodes with the seizure onset zone in the total number of seizures in each patient. Significance was considered at an adjusted p-value of 0.05.
  
  
  RESULTS
  By the maximum amplitude method with the Bonferroni correction, only high-frequency activities (>60 Hz) during -5 to 0 s from the ictal onset were significantly related to seizure onset zones. In post hoc analyses, bands in 60-139 Hz and 4-7 Hz were significantly related to seizure onset zones in the Bonferroni correction. However, after the less conservative Benjamini-Yekutieli correction and with the epileptogenicity index, other bands and periods after -10s from the ictal onset were also related with seizure onset zones.
  
  
  CONCLUSIONS
  Detailed bands, timings and analytic methods of peri-ictal activities with high relationships to seizure onset zones were identified.
authors.affiliation: Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Seong-Cheol
authors.initials: SC
authors.lastname: Park
authors.affiliation: Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Sang Kun
authors.initials: SK
authors.lastname: Lee
authors.affiliation: Department of Neurosurgery, Seoul National University College of Medicine, Seoul, Republic of Korea; Magnetoencephalography Centre, Seoul National University Hospital, Seoul, Republic of Korea; Neuroscience Research Institute, Seoul National University Medical Research Centre, Seoul, Republic of Korea. Electronic address: chungc@snu.ac.kr.
authors.forename: Chun Kee
authors.initials: CK
authors.lastname: Chung
mesh_terms: D000328:Adult; D016000:Cluster Analysis; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012640:Seizures / Q000503:physiopathology* / Q000601:surgery / Q000628:therapy; D016896:Treatment Outcome; D058067:Wavelet Analysis
keywords: Electrocorticography; Epilepsy; Epilepsy surgery; Epileptiform EEG discharges; Intracranial electroencephalogram