title: Detection of Helicobacter pylori in Oral Lesions.
abstract: Background and aims. Helicobacter pylori is a microaerophilic gram-negative spiral organism. It is recognized as the etiologic factor for peptic ulcers, gastric adenocarcinoma and gastric lymphoma. Recently, it has been isolated from dental plaque and the dorsum of the tongue. This study was designed to assess the association between H. pylori and oral lesions such as ulcerative/inflammatory lesions, squamous cell carcinoma (SCC) and primary lymphoma. Materials and methods. A total of 228 biopsies diagnosed as oral ulcerative/inflammatory lesions, oral squamous cell carcinoma (OSCC) and oral primary lymphoma were selected from the archives of the Pathology Department. Thirty-two samples that were diagnosed as being without any pathological changes were selected as the control group. All the paraffin blocks were cut for hematoxylin and eosin staining to confirm the diagnoses and then the samples were prepared for immunohistochemistry staining. Data were collected and analyzed. Results. Chi-squared test showed significant differences between the frequency of H. pylori positivity in normal tissue and the lesions were examined (P=0.000). In addition, there was a statistically significant difference between the lesions examined (P=0.042). Chi-squared test showed significant differences between H. pylori positivity and different tissue types except inside the muscle layer as follows: in epithelium and in lamina propria (P=0.000), inside the blood vessels (P=0.003), inside the salivary gland duct (P=0.036), and muscle layer (P=0.122). Conclusion. There might be a relation between the presence of H. pylori and oral lesions. Therefore, early detection and eradication of H. pylori in high-risk patients are suggested.
authors.affiliation: Assistant Professor, Department of Oral & Maxillofacial Pathologisty, Dental Faculty, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Soussan
authors.initials: S
authors.lastname: Irani
authors.affiliation: Associate Professor, Anatomical Pathologist, Department of Pathology, Medical School, Hamadan University of Medical Sciences, Hamadan, Iran.
authors.forename: Alireza
authors.initials: A
authors.lastname: Monsef Esfahani
authors.affiliation: Assistant Professor, Anatomical Pathologist, Department of Pathology, Medical School, Shahid Beheshti University of Medical Sciences, HakimLoghman Hospital, Tehran, Iran.
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Bidari Zerehpoush
keywords: Helicobacter pylori; oral lymphoma; oral squamous cell carcinoma; oral ulcer