title: α-Haloacrylates as acceptors in the [3 + 2] cycloaddition reaction with NaN3: an expedient approach to N-unsubstituted 1,2,3-triazole-4-carboxylates.
abstract: An expedient synthesis of N-unsubstituted 1,2,3-triazole-4-carboxylates has been demonstrated through [3 + 2] cycloaddition of sodium azide with α-haloacrylates. The process is highly reliable and exhibits an unusually wide scope with respect to α-fluoro-, α-chloro-, α-bromo-, and α-iodoacrylates. The potential of selected 1,2,3-triazole-4-carboxylates in the preparation of 1,5-dihydro-4H-[1,2,3]-triazolo-[4,5-c]-quinolin-4-one has also been illustrated.
authors.affiliation: Syngene International Ltd., Biocon Park, Plot Nos. 2 & 3, Bommasandra IV Phase, Jigani Link Road, Bangalore 560 099, India. john.kallikat@syngeneintl.com john.kallikat@gmail.com.
authors.forename: John Kallikat
authors.initials: JK
authors.lastname: Augustine
authors.forename: Chandrakantha
authors.initials: C
authors.lastname: Boodappa
authors.forename: Srinivasa
authors.initials: S
authors.lastname: Venkatachaliah
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D003500:Cyclization; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure; D019810:Sodium Azide / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000179:Acrylates; D006846:Hydrocarbons, Halogenated; D014230:Triazoles; D019810:Sodium Azide