title: Development of the mammalian lymphatic vasculature.
abstract: The two vascular systems of our body are the blood and lymphatic vasculature. Our understanding of the cellular and molecular processes controlling the development of the lymphatic vasculature has progressed significantly in the last decade. In mammals, this is a stepwise process that starts in the embryonic veins, where lymphatic EC (LEC) progenitors are initially specified. The differentiation and maturation of these progenitors continues as they bud from the veins to produce scattered primitive lymph sacs, from which most of the lymphatic vasculature is derived. Here, we summarize our current understanding of the key steps leading to the formation of a functional lymphatic vasculature.
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Guillermo
authors.initials: G
authors.lastname: Oliver
mesh_terms: D042501:Angiogenic Proteins / Q000502:physiology; D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D042583:Lymphangiogenesis; D042601:Lymphatic Vessels / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D015398:Signal Transduction
chemical_list: D042501:Angiogenic Proteins