title: [Serum GP73 were increased in patients with fatty liver disease].
abstract: OBJECTIVE
  To explore the levels of serum GP73 in patients with fatty liver disease.
  
  
  METHODS
  The sera GP73 were determined by ELISA in 178 patients with fatty liver disease and 100 healthy controls.
  
  
  RESULTS
  Serum GP73 levels were significantly increased in patients with various fatty liver diseases(70.62 +/- 60.60 ng/ml), compared with those of control population (35.61 +/- 12.22 ng/ml). In patients with alcoholic fatty liver disease, acute liver injury, chronic hepatitis B, and non-alcoholic fatty liver disease, their serum GP73 concentration were 81.86 +/- 47.82 ng/ml, 82.77 +/- 77.73 ng/ml, 63.84 +/- 50.62 ng/ml, and 65.75 +/- 62.20 ng/ml, respectively. But no significant difference was found between these groups (P > 0.05). In 68 patients with F > or = 1.0 (71.46 +/- 66.48 ng/ml), 75 patients with F> or = 2.0 (69.58 +/- 62.31 ng/ml), and 34 patients with F3-F4 (71.65 +/- 43.89 ng/ml), there were also no marked differences was observed between these fatty groups (F = 0.02, P = 0.98).
  
  
  CONCLUSIONS
  Serum GP73 levels were increased in patients with different liver diseases, but its concentrations were seems not related with degree of fatty injury.
authors.affiliation: Institute of Infectious Diseases, Capital Medical University, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Hong-Shan
authors.initials: HS
authors.lastname: Wei
authors.affiliation: Institute of Infectious Diseases, Capital Medical University, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Kang
authors.affiliation: Institute of Infectious Diseases, Capital Medical University, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Hao
authors.affiliation: Institute of Infectious Diseases, Capital Medical University, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.affiliation: Institute of Infectious Diseases, Capital Medical University, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Hong-Min
authors.initials: HM
authors.lastname: Li
authors.affiliation: Institute of Infectious Diseases, Capital Medical University, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Ai-Xia
authors.initials: AX
authors.lastname: Liu
authors.affiliation: Institute of Infectious Diseases, Capital Medical University, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Ren
authors.affiliation: Institute of Infectious Diseases, Capital Medical University, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Yu-Bo
authors.initials: YB
authors.lastname: Huang
authors.affiliation: Institute of Infectious Diseases, Capital Medical University, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Bo-An
authors.initials: BA
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005234:Fatty Liver / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D055815:Young Adult
chemical_list: C410824:GOLM1 protein, human; D008565:Membrane Proteins