title: Role of ethyl pyruvate in systemic inflammatory response and lung injury in an experimental model of ruptured abdominal aortic aneurysm.
abstract: OBJECTIVE
  The purpose of this study is to evaluate the effect of ethyl pyruvate (EP) on systemic inflammatory response and lung injury in an experimental rat model of ruptured abdominal aortic anurysm (RAAA).
  
  
  METHODS
  Anaesthetized 30 Sprague-Dawley male rats were randomized to sham (Sh n : 6) (Sh + EP n : 6) or shock and clamp (S/C) groups (S/C n : 9) (S/C + EP n : 9). In the S/C and S/C + EP groups, hemorrhagic shock, lower torso ischemia, and reperfusion were created, S/C group was given 1 mL saline and S/C + EP group was given 40 mg/kg EP. At the end of reperfusion process some biochemical and histological parameters were studied in serum and lung tissues.
  
  
  RESULTS
  An increase was observed in all parameters except interleukin-6 (IL-6) in the S/C group in comparison to the sham groups. In the S/C + EP group, serum myeloperoxydase (MPO), malondialdehyde (MDA), and tumor necrosis factor alpha (TNF-α) as well as lung MPO and MDA values decreased significantly (P < 0.016). In the lung tissues, histological injury scores and lung tissue wet/dry ratio were significantly decreased in the S/C + EP group as compared to the S/C group (P < 0.016).
  
  
  CONCLUSIONS
  Ethyl pyruvate may reduce systemic inflammatory response and lung injury which resulted from shock and ischemia/reperfusion in an experimental model of RAAA.
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Pulathan
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: Gökalp
authors.identifier: 0000-0003-1116-6594
authors.initials: G
authors.lastname: Altun
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: Doğuş
authors.initials: D
authors.lastname: Hemşinli
authors.affiliation: Depertment of Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: Ahmet
authors.identifier: 0000-0003-2036-5317
authors.initials: A
authors.lastname: Menteşe
authors.affiliation: Depertment of Histology and Embryology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Yuluğ
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Civelek
mesh_terms: D017542:Aneurysm, Ruptured / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D055370:Lung Injury / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology; D018746:Systemic Inflammatory Response Syndrome / Q000378:metabolism* / Q000473:pathology
chemical_list: D011773:Pyruvates; C046522:ethyl pyruvate