title: Hemimegalencephaly without epilepsy: case report.
abstract: Hemimegalencephaly is a rare sporadic brain malformation characterized by enlargement of one cerebral hemisphere. The classical clinical triad consists of intractable epilepsy, severe psychomotor delay and hemiparesis. In this report, we describe a case of a 3-year-old girl, with all the radiological features of severe hemimegalencephaly but with a comparatively benign clinical course. She had no hemiparesis, mild delay and no seizures. An extensive literature review reveals only one previously reported case of hemimegalencephaly with the absence of seizures, as part of case series. This is the first dedicated case report, with clinical description and radiological images, of this entity.
authors.affiliation: Department of Neurosurgery, Great Ormond Street Hospital for Children, London, WC1N 3JH, UK, greg.james@nhs.net.
authors.forename: Greg
authors.initials: G
authors.lastname: James
authors.forename: Mano
authors.initials: M
authors.lastname: Shanmuganathan
authors.forename: William
authors.initials: W
authors.lastname: Harkness
mesh_terms: D002675:Child, Preschool; D004827:Epilepsy / Q000175:diagnosis; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D065705:Hemimegalencephaly / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging