title: Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides.
abstract: Positron emission tomography (PET) is a highly sensitive quantitative imaging technique for studying molecular pathways and interactions in vivo. This imaging technique plays a key role in drug discovery, pharmacokinetics, pharmacodynamics, and assessing in vivo distribution. In this study, we designed an ethynylbenzene-substituted glycol (M(E)) as a versatile probe for PET labeling of oligonucleotides through a click reaction.
authors.affiliation: United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Qin
authors.initials: Q
authors.lastname: Ren
authors.affiliation: Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Kana
authors.initials: K
authors.lastname: Tsunaba
authors.affiliation: Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kitamura
authors.affiliation: United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Remi
authors.initials: R
authors.lastname: Nakashima
authors.affiliation: Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Shibada
authors.affiliation: United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Ikeda
authors.affiliation: United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Biomolecular Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan. Electronic address: ykkitade@gifu-u.ac.jp.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kitade
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry; D057930:Click Chemistry; D006018:Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D015335:Molecular Probes / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D049268:Positron-Emission Tomography; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D006018:Glycols; D015335:Molecular Probes; D009841:Oligonucleotides; C044736:phenylacetylene; D000114:Acetylene
keywords: Alkynes; Artificial nucleoside; Click chemistry; Huisgen cycloaddition; Stereoselective synthesis