title: Novel lycorine derivatives as anticancer agents: synthesis and in vitro biological evaluation.
abstract: Lycorine, which is the most abundant alkaloid isolated from the Amaryllidaceae family of plants, reportedly exhibits promising anticancer activities. Herein, a series of novel lycorine derivatives were synthesized and evaluated for their in vitro inhibitory activities against seven different cancer cell lines, including A549, HCT116, SK-OV-3, NCI-H460, K562, MCF-7 and HL-60. The results indicated that compounds bearing diverse amine substituents at the C-2 position demonstrated good anticancer activities. The selectivity towards different cancer cell lines of the synthesized derivatives is discussed.
authors.affiliation: College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.affiliation: College of Life Sciences, Nankai University, Tianjin 300071, China.
authors.forename: Hui-Hui
authors.initials: HH
authors.lastname: Yuan
authors.affiliation: College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.affiliation: College of Life Sciences, Nankai University, Tianjin 300071, China.
authors.forename: Yun-Ping
authors.initials: YP
authors.lastname: Li
authors.affiliation: College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China. shanglq@nankai.edu.cn.
authors.forename: Lu-Qing
authors.initials: LQ
authors.lastname: Shang
authors.affiliation: College of Pharmacy & State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China. zheng_yin@nankai.edu.cn.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Yin
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D045325:HCT116 Cells; D006801:Humans; D019668:Liliaceae / Q000737:chemistry; D010617:Phenanthridines / Q000008:administration & dosage* / Q000138:chemical synthesis* / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D047151:Amaryllidaceae Alkaloids; D000970:Antineoplastic Agents; D010617:Phenanthridines; D010936:Plant Extracts; C015330:lycorine