title: Itraconazole prophylaxis for invasive Aspergillus infection in lung transplantation.
abstract: Invasive Aspergillus infection (IA) is a significant cause of morbidity in lung transplantation (LT). However, its optimal prophylaxis is unclear. We routinely administer itraconazole (ITCZ) prophylaxis to all patients undergoing LT. In this study, we retrospectively evaluated the duration of prophylaxis and risk factors of IA. Among 30 adult patients who underwent LT, 5 patients developed IA. All patients with IA stopped ITCZ treatment within 1 year. At least 1 year of ITCZ prophylaxis is essential for the prevention of IA. Cytomegalovirus infection, renal replacement therapy, and tracheotomy were risk factors for IA.
authors.affiliation: Department of Clinical Laboratory Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Nagao
authors.forename: S
authors.initials: S
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Yunoki
authors.forename: G
authors.initials: G
authors.lastname: Hotta
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Y
authors.initials: Y
authors.lastname: Ito
authors.forename: S
authors.initials: S
authors.lastname: Takakura
authors.forename: F
authors.initials: F
authors.lastname: Chen
authors.forename: T
authors.initials: T
authors.lastname: Bando
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuda
authors.forename: K
authors.initials: K
authors.lastname: Matsubara
authors.forename: H
authors.initials: H
authors.lastname: Date
authors.forename: S
authors.initials: S
authors.lastname: Ichiyama
mesh_terms: D000328:Adult; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D003586:Cytomegalovirus Infections / Q000150:complications; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D055732:Pulmonary Aspergillosis / Q000517:prevention & control*; D017582:Renal Replacement Therapy; D012189:Retrospective Studies; D012307:Risk Factors; D014140:Tracheotomy
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole
keywords: invasive Aspergillus infection; itraconazole; lung transplantation; prophylaxis duration; therapeutic drug monitoring