title: Preliminary pharmacokinetics of PEGylated oxaliplatin polylactic acid nanoparticles in rabbits and tumor-bearing mice.
abstract: To testify the targeting effect of PEGylated Oxaliplatin polylactic acid (OP-PEG-PLA) nanoparticles (NPs), we studied drug concentration in rabbit plasma and tissue distribution in tumor-bearing mice. Concentration of nanoparticle colloidal solution was performed with dialysis. Qualities of enriched NPs were characterized by particle size and drug content. OP concentration in samples was detected using ICP-MS. Compared to OP solution groups, OP concentration of NPs groups increased in the tumor (p < 0.05) and decreased in the kidney and heart (p < 0.05). Compared to OP-PLA NPs groups, OP concentration of OP-PEG-PLA NPs groups increased in the tumor and decreased in the liver and lung (p < 0.05). The concentrated OP-PEG-PLA NPs are good in clinical application and tumor delivery.
authors.affiliation: Department of Pharmaceutical , Qingdao , P. R. China.
authors.forename: Haitian
authors.initials: H
authors.lastname: Wei
authors.forename: Lisa
authors.initials: L
authors.lastname: Xu
authors.forename: Yong
authors.initials: Y
authors.lastname: Sun
authors.forename: Gaohong
authors.initials: G
authors.lastname: Li
authors.forename: Zhaoyuan
authors.initials: Z
authors.lastname: Cui
authors.forename: Guowen
authors.initials: G
authors.lastname: Yan
authors.forename: Qian
authors.initials: Q
authors.lastname: Chen
authors.forename: Hongli
authors.initials: H
authors.lastname: Yin
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
mesh_terms: D000818:Animals; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D019344:Lactic Acid / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000077150:Oxaliplatin; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011817:Rabbits
chemical_list: D004337:Drug Carriers; D009944:Organoplatinum Compounds; D011091:Polyesters; D011108:Polymers; D000077150:Oxaliplatin; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide); C000595209:polyethylene glycol 1000
keywords: nanoparticle; oxaliplatin; pharmacokinetics; tumor