title: Hendra virus vaccine, a one health approach to protecting horse, human, and environmental health.
abstract: In recent years, the emergence of several highly pathogenic zoonotic diseases in humans has led to a renewed emphasis on the interconnectedness of human, animal, and environmental health, otherwise known as One Health. For example, Hendra virus (HeV), a zoonotic paramyxovirus, was discovered in 1994, and since then, infections have occurred in 7 humans, each of whom had a strong epidemiologic link to similarly affected horses. As a consequence of these outbreaks, eradication of bat populations was discussed, despite their crucial environmental roles in pollination and reduction of the insect population. We describe the development and evaluation of a vaccine for horses with the potential for breaking the chain of HeV transmission from bats to horses to humans, thereby protecting horse, human, and environmental health. The HeV vaccine for horses is a key example of a One Health approach to the control of human disease.
authors.forename: Deborah
authors.initials: D
authors.lastname: Middleton
authors.forename: Jackie
authors.initials: J
authors.lastname: Pallister
authors.forename: Reuben
authors.initials: R
authors.lastname: Klein
authors.forename: Yan-Ru
authors.initials: YR
authors.lastname: Feng
authors.forename: Jessica
authors.initials: J
authors.lastname: Haining
authors.forename: Rachel
authors.initials: R
authors.lastname: Arkinstall
authors.forename: Leah
authors.initials: L
authors.lastname: Frazer
authors.forename: Jin-An
authors.initials: JA
authors.lastname: Huang
authors.forename: Nigel
authors.initials: N
authors.lastname: Edwards
authors.forename: Mark
authors.initials: M
authors.lastname: Wareing
authors.forename: Martin
authors.initials: M
authors.lastname: Elhay
authors.forename: Zia
authors.initials: Z
authors.lastname: Hashmi
authors.forename: John
authors.initials: J
authors.lastname: Bingham
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamada
authors.forename: Dayna
authors.initials: D
authors.lastname: Johnson
authors.forename: John
authors.initials: J
authors.lastname: White
authors.forename: Adam
authors.initials: A
authors.lastname: Foord
authors.forename: Hans G
authors.initials: HG
authors.lastname: Heine
authors.forename: Glenn A
authors.initials: GA
authors.lastname: Marsh
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Broder
authors.forename: Lin-Fa
authors.initials: LF
authors.lastname: Wang
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D004782:Environmental Health; D005260:Female; D005289:Ferrets; D006168:Guinea Pigs; D045404:Hendra Virus / Q000235:genetics / Q000276:immunology*; D045464:Henipavirus Infections / Q000517:prevention & control*; D006734:Horse Diseases / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D006736:Horses; D006801:Humans; D007114:Immunization; D009500:Neutralization Tests; D014765:Viral Vaccines / Q000276:immunology*; D015047:Zoonoses / Q000473:pathology / Q000517:prevention & control* / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines
keywords: Australia; G glycoprotein; HeV; HeV vaccine; Hendra virus; One Health; Pteropus bats; environment; flying foxes; horses; humans; vaccination; vaccine; viruses; zoonoses; zoonotic paramyxovirus