title: Scavenger receptor class B type I and immune dysfunctions.
abstract: OBJECTIVE
  To summarize the recent findings about the roles of scavenger receptor class B type I (SR-BI) in immunity and discuss the underlying mechanisms by which SR-BI prevents immune dysfunctions.
  
  
  RESULTS
  SR-BI is well known as a high-density lipoprotein (HDL) receptor playing key roles in HDL metabolism and in protection against atherosclerosis. Recent studies have indicated that SR-BI is also an essential modulator in immunity. SR-BI deficiency in mice causes immune dysfunctions, including increased atherosclerosis, elevated susceptibility to sepsis, impaired lymphocyte homeostasis, and autoimmune disorders. SR-BI exerts its protective roles through a variety of HDL-dependent and HDL-independent mechanisms. SR-BI is also involved in hepatitis C virus cell entry. A deficiency of SR-BI in humanized mice has been shown to decrease hepatitis C virus infectivity.
  
  
  CONCLUSIONS
  SR-BI regulates immunity via multiple mechanisms and its deficiency causes numerous diseases. A comprehensive understanding of the roles of SR-BI in protection against immune dysfunctions may provide a therapeutic target for intervention against its associated diseases.
authors.affiliation: aDepartment of Pediatrics bGraduate Center for Nutritional Sciences cSaha Cardiovascular Research Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
authors.forename: Zhong
authors.initials: Z
authors.lastname: Zheng
authors.forename: Junting
authors.initials: J
authors.lastname: Ai
authors.forename: Xiang-An
authors.initials: XA
authors.lastname: Li
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D050197:Atherosclerosis / Q000276:immunology* / Q000378:metabolism; D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism / Q000517:prevention & control*; D049109:Cell Proliferation; D004195:Disease Models, Animal; D006801:Humans; D008075:Lipoproteins, HDL / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D018384:Oxidative Stress / Q000276:immunology*; D018110:Receptors, Lipoprotein / Q000276:immunology; D051122:Scavenger Receptors, Class B / Q000172:deficiency / Q000276:immunology*; D018805:Sepsis / Q000276:immunology* / Q000378:metabolism
chemical_list: D008075:Lipoproteins, HDL; D018110:Receptors, Lipoprotein; D051122:Scavenger Receptors, Class B; C031616:high density lipoprotein receptors