title: Relation between copper, lipid profile, and cognition in elderly Jordanians.
abstract: The purpose of the current study was to examine the association of serum copper and lipid concentrations with changes in cognitive function in elderly Jordanian individuals. The study population consisted of two groups: 52 dementia patients and 50 control subjects. All individuals were screened using the Mini-Mental State Examination and Clock Drawing Test. Serum copper and lipid profile were also assessed. Results were statistically evaluated at p < 0.05 level of significance. The dementia group had 10.1% higher copper level than control subjects that was not statistically significant. No significant differences could be found between the two groups in lipid profile levels. There was no significant correlation between serum copper, lipid profile, and cognitive decline in elderly Jordanians. Demographic variables indicated that educational level less than 12 years and illiterate demonstrated a 3.29 fold (p = 0.026) and 6.29 fold (p = 0.002) increase in risk of developing dementia, respectively. Coffee intake demonstrated a protective effect against cognitive decline with 6.25 fold lower risk with increased coffee intake.
authors.affiliation: Department of Physiology & Biochemistry, University of Jordan, Amman, Jordan.
authors.forename: Eman
authors.initials: E
authors.lastname: Al-khateeb
authors.affiliation: Department of Physiology & Biochemistry, University of Jordan, Amman, Jordan.
authors.forename: Ebaa
authors.initials: E
authors.lastname: Al-zayadneh
authors.affiliation: Medical students, Faculty of Medicine, University of Jordan, Amman, Jordan.
authors.forename: Osama
authors.initials: O
authors.lastname: Al-dalahmah
authors.affiliation: Medical students, Faculty of Medicine, University of Jordan, Amman, Jordan.
authors.forename: Zeinab
authors.initials: Z
authors.lastname: Alawadi
authors.affiliation: Department of Physiology & Biochemistry, University of Jordan, Amman, Jordan.
authors.forename: Faisal
authors.initials: F
authors.lastname: khatib
authors.affiliation: Department of Physiology & Biochemistry, University of Jordan, Amman, Jordan.
authors.forename: Randa
authors.initials: R
authors.lastname: Naffa
authors.affiliation: Department of Physiology & Biochemistry, University of Jordan, Amman, Jordan.
authors.forename: Yanal
authors.initials: Y
authors.lastname: Shafagoj
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001774:Blood Chemical Analysis; D003069:Coffee; D003071:Cognition; D003300:Copper / Q000097:blood*; D003704:Dementia / Q000097:blood* / Q000453:epidemiology* / Q000523:psychology; D004032:Diet; D004522:Educational Status; D005260:Female; D006801:Humans; D007597:Jordan / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008297:Male; D017533:Marital Status; D008875:Middle Aged; D009483:Neuropsychological Tests; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D012737:Sex Factors; D013261:Sterols / Q000097:blood
chemical_list: D003069:Coffee; D008055:Lipids; D000069463:Olive Oil; D010938:Plant Oils; D013261:Sterols; D003300:Copper
keywords: Alzheimer's disease; cholesterol; coffee; copper; dementia; lipid profile