title: Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients.
abstract: A deletion of two genes from the late cornified envelope (LCE), LCE3B and LCE3C within epidermal differentiation complex on chromosome 1 was shown to be associated with both psoriasis and psoriatic arthritis (PsA) in several populations. To assess whether this deletion may contribute to the genetic predisposition to PsA in Tunisia, a total of 73 patients with PsA and 120 healthy matched controls were screened for the deletion, LCE3C_LCE3B-del, and its tag SNP, rs4112788. We also evaluated a possible relationship between PSORS1 and LCE3C_LCE3B-del through genotyping two proxy markers to HLA-C (rs12191877 and rs2073048). Our results did not provide evidence for association between the LCE3C_LCE3B-del nor the rs4112788 and the PsA. Similarly, no significant epistatic effect was observed. Our data suggest that The LCE deletion, previously identified in patients with psoriasis, is not of a major importance in the development of PsA in Tunisian patients supporting the current perception that different genetic risk factors contribute to skin and joint disease. However, these results need to be confirmed by additional large-scale studies of Tunisian PsA patients and controls.
authors.affiliation: Laboratory of Genetics, Immunology and Human Pathologies, Faculty of Sciences, University of Tunis El Manar, 2092, Tunis, Tunisia, souissichiraz@topnet.tn.
authors.forename: Bouchlaka Souissi
authors.initials: BS
authors.lastname: Chiraz
authors.forename: Ammar
authors.initials: A
authors.lastname: Myriam
authors.forename: Zarra
authors.initials: Z
authors.lastname: Ines
authors.forename: Jordan
authors.initials: J
authors.lastname: Catherine
authors.forename: Bouazizi
authors.initials: B
authors.lastname: Fatma
authors.forename: Cheour
authors.initials: C
authors.lastname: Ilhem
authors.forename: Tekaya
authors.initials: T
authors.lastname: Raoudha
authors.forename: Zeglaoui
authors.initials: Z
authors.lastname: Hela
authors.forename: Fourati
authors.initials: F
authors.lastname: Hela
authors.forename: Bouajina
authors.initials: B
authors.lastname: Elyes
authors.forename: Doss
authors.initials: D
authors.lastname: Nejib
authors.forename: Helms
authors.initials: H
authors.lastname: Cindy
authors.forename: Elgaaied
authors.initials: E
authors.lastname: Amel
authors.forename: Sellami
authors.initials: S
authors.lastname: Slaheddine
mesh_terms: D000328:Adult; D015535:Arthritis, Psoriatic / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D055233:Cornified Envelope Proline-Rich Proteins / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics; D014416:Tunisia
chemical_list: D055233:Cornified Envelope Proline-Rich Proteins; D015236:HLA-C Antigens; C549748:LCE3B protein, human; C524768:LCE3C protein, human; C484393:PSORS1C1 protein, human; D011506:Proteins