title: An unusual case of influenza-like illness after yellow fever vaccination.
abstract: Yellow fever (YF) is an important public health concern in areas where the disease is endemic. For more than 60 years a highly effective live attenuated vaccine has been available, its widespread use resulting in a dramatic decrease in the number of cases. On rare occasions, YF vaccine can cause mild to severe disease and rare adverse vaccine-associated events have been reported. Additionally, an average viremia of 3-5 days after administration of the YF vaccine has been published. Here we present a case where YF vaccine was isolated in cell culture from a respiratory swab collected from a patient presenting with influenza-like illness. To the best of our knowledge, this is the first report finding replicating YF vaccine in the respiratory sample of a post inoculated individual.
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, NY, USA. Electronic address: dml20@health.state.ny.us.
authors.forename: Daryl M
authors.initials: DM
authors.lastname: Lamson
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: Rama
authors.initials: R
authors.lastname: Ramani
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: Matthew
authors.initials: M
authors.lastname: Kleabonas
authors.affiliation: Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Maureen
authors.initials: M
authors.lastname: Metcalfe
authors.affiliation: Infectious Diseases Pathology Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Humphrey
authors.affiliation: Wadsworth Center, New York State Department of Health, Albany, NY, USA.
authors.forename: Kirsten
authors.initials: K
authors.lastname: St George
mesh_terms: D005260:Female; D006801:Humans; D012137:Respiratory System / Q000821:virology*; D012141:Respiratory Tract Infections / Q000175:diagnosis* / Q000473:pathology*; D014611:Vaccination / Q000009:adverse effects*; D014776:Virus Cultivation; D022341:Yellow Fever Vaccine / Q000008:administration & dosage* / Q000009:adverse effects*; D015005:Yellow fever virus / Q000302:isolation & purification*; D055815:Young Adult
chemical_list: D022341:Yellow Fever Vaccine
keywords: Electron microscopy; Influenza-like illness; Yellow fever virus vaccine