title: A study of hepcidin and monocyte chemoattractant protein-1 in Egyptian females with systemic lupus erythematosus.
abstract: BACKGROUND
  Lupus nephritis is one of the most serious manifestations of systemic lupus erythematosus (SLE). Novel biomarkers are necessary to enhance the diagnostic accuracy, prognostic stratification, monitoring of treatment response, and detection of early renal flares.
  
  
  METHODS
  Our study was conducted on 90 participants. They were divided into three groups, group I (controls) encompassed 30 ages and sex-matched healthy personnel. Group II included 30 non-nephritic SLE patients and finally group III included 30 SLE nephritic patients. Urinary monocyte chemoattractant protein-1 (UMCP-1) and hepcidin were evaluated by ELISA technique, compared and correlated in different groups, with each other and with other routine variables and with renal biopsy done to study group (III).
  
  
  RESULTS
  Both UMCP-1 and hepcidin in group III showed significant increase compared to other two groups (controls and group II) (468 ± 128, 111 ± 12, 252 ± 56 pg/ml, respectively, for UMCP-1 and 40 ± 12, 11 ± 2, 20 ± 5 ng/ml, respectively, for hepcidin, P < 0.01). Also both UMCP-1 and hepcidin in group III showed significant increase in diffuse proliferative subgroup compared to focal proliferative and mesangioproliferative subgroups (580 ± 43, 502 ± 46, and 352.6 ± 100 pg/ml, respectively, for UMCP-1 and 47.8 ± 9.5, 41.4 ± 6, and 32.9 ± 10.8 ng/ml, respectively, for urinary hepcidin, P < 0.05).
  
  
  CONCLUSIONS
  UMCP-1 and hepcidin could be associated with the susceptibility of lupus nephritis.
authors.affiliation: Internal Medicine Department, Cairo University, Giza, Egypt.
authors.forename: Moataz Fatthy
authors.initials: MF
authors.lastname: Mohammed
authors.forename: Dawlat
authors.initials: D
authors.lastname: Belal
authors.forename: Seham
authors.initials: S
authors.lastname: Bakry
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Marie
authors.forename: Laila
authors.initials: L
authors.lastname: Rashed
authors.forename: Reham Emad
authors.initials: RE
authors.lastname: Eldin
authors.forename: Samah Abd
authors.initials: SA
authors.lastname: El-Hamid
mesh_terms: D000293:Adolescent; D000328:Adult; D018932:Chemokine CCL2 / Q000652:urine*; D004534:Egypt; D005260:Female; D064451:Hepcidins / Q000652:urine*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000652:urine*; D008875:Middle Aged; D055815:Young Adult
chemical_list: D018932:Chemokine CCL2; D064451:Hepcidins
keywords: hepcidin; lupus nephritis; monocyte chemoattractant protein-1; urinary biomarkers