title: Recombinant stem cells as carriers for cancer gene therapy.
abstract: Recent studies have shown the ability of mesenchymal stem cells (MSCs) to migrate toward and engraft into the tumor sites, which provides a potential for their use as carriers for cancer gene therapy. Here, we describe the strategies of using MSCs as carriers for cancer gene therapy using a nonviral transfection method.
authors.affiliation: Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang, P.R. China.
authors.forename: Yu-Lan
authors.initials: YL
authors.lastname: Hu
authors.forename: Jian-Qing
authors.initials: JQ
authors.lastname: Gao
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D015415:Biomarkers / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D017930:Genes, Reporter; D015316:Genetic Therapy / Q000379:methods*; D018664:Interleukin-12 / Q000235:genetics / Q000378:metabolism; D008156:Luciferases / Q000235:genetics / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary / Q000628:therapy*; D008297:Male; D008546:Melanoma, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010957:Plasmids / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D014162:Transfection / Q000379:methods*
chemical_list: D015703:Antigens, CD; D015415:Biomarkers; D018664:Interleukin-12; D008156:Luciferases