title: Comparative performance of two whitening systems in a dental practice.
abstract: OBJECTIVE
  A randomized, controlled clinical trial was conducted to compare the safety and whitening efficacy of high-adhesion tooth-whitening strips with a marketed in-office professional tooth-whitening system.
  
  
  METHODS
  This open-label study was conducted in a private dental practice, and adult volunteers were assigned (2:1) to either 9.5 percent hydrogen-peroxide whitening strips (Strip group) or an in-office light plus 25 percent hydrogen-peroxide whitening gel treatment (In-office group). The Strip group was instructed to treat the maxillary arch once daily for 30 minutes over a 20-day period, while the In-office group underwent professional application of light plus whitening gel in a single office visit. Whitening response was measured as change in yellowness (b*) and lightness (L*) at Day 21 using standardized digital images of the maxillary anterior teeth, while safety was assessed as tooth sensitivity and oral irritation occurrence. A total of 45 subjects enrolled, were randomized, and received treatment; 44 completed the study.
  
  
  RESULTS
  At Day 21, significant improvement in b* and L* was noted in both groups (P≤0.001). The adjusted mean (SE) ΔL* in the Strip group (1.72 (0.104)) was significantly greater than that in the In-office group (1.17 (0.153)) (P = 0.005). Both test products were well tolerated. Overall, both the strip and in-office treatments resulted in significant tooth whitening.
authors.affiliation: Clinical Associate Professor of Periodontics, University of Maryland Dental School, Baltimore, Maryland; Private Practice, Yardley, Pennsylvania.
authors.forename: Ronald
authors.initials: R
authors.lastname: Perry
authors.affiliation: Clinical Trial Manager, The Procter and Gamble Company, Mason, Ohio.
authors.forename: Erinn
authors.initials: E
authors.lastname: Conde
authors.affiliation: Section Head, Clinical Research for Oral Care, The Procter and Gamble Company, Mason, Ohio.
authors.forename: Svetlana
authors.initials: S
authors.lastname: Farrell
authors.affiliation: Research Fellow in Worldwide Clinical Investigations, The Procter and Gamble Company, Mason, Ohio.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Gerlach
authors.affiliation: Director of Dental Research, Tufts University School of Dental Medicine, Boston, Massachusetts.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Towers
mesh_terms: D000293:Adolescent; D000328:Adult; D003807:Dentin Sensitivity / Q000139:chemically induced; D005260:Female; D005782:Gels; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D014073:Tooth Bleaching / Q000379:methods*; D014075:Tooth Discoloration / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D005782:Gels; D016877:Oxidants; D006861:Hydrogen Peroxide