title: Comparison of tissue damages caused by endoscopic lumbar discectomy and traditional lumbar discectomy: a randomised controlled trial.
abstract: OBJECTIVE
  This study aimed to compare the clinical efficacies of percutaneous endoscopic lumbar discectomy (PELD) and traditional open lumbar discectomy (OD).
  
  
  METHODS
  The pre-operative and post-operative blood loss, hospital stays and wound sizes of the patients in the two groups were recorded. Enzyme-Linked immunosorbent assay was used to measure the changes of interleukin-6 (IL-6), C-reactive protein (CRP) and creatine phosphokinase (CPK) pre-operation and 1 h, 6 h, 12 h, 24 h and 48 h after corresponding surgery. Visual Analog Scale and Modified MacNab Criteria were used to assess post-operative results.
  
  
  RESULTS
  Patients in the PELD group had less blood loss (p < 0.01), shorter hospitalization hours (p < 0.01) and smaller surgical wounds (p < 0.01) than the patients underwent traditional OD surgery. MacNab evaluated that the levels of satisfaction were above 90% in both groups post-operative six months. There was no significant difference in pain index between the two groups (p > 0.05). Furthermore, the levels of CRP, CPK and IL-6 in the PELD group were all lower than those in the OD group with a significant difference (p < 0.01).
  
  
  CONCLUSIONS
  The PELD had less damage to human tissues than the traditional OD. PELD has a clear promotional value in clinical.
authors.affiliation: Department of Orthopaedics Surgery, The People's Hospital of Foshan, Sanshui District, Foshan 528100, Guangdong Province, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Pan
authors.affiliation: Department of Respiratory Medicine, The First People's Hospital of Foshan, Foshan 528000, Guangdong Province, China.
authors.forename: Peifang
authors.initials: P
authors.lastname: Zhang
authors.affiliation: Department of Orthopaedics Surgery, Liuhuaqiao Hospital, Guangzhou 510010, Guangdong Province, China. Electronic address: gz_yqs@126.com.
authors.forename: Qingshui
authors.initials: Q
authors.lastname: Yin
mesh_terms: D017586:Diskectomy / Q000009:adverse effects* / Q000379:methods*; D017587:Diskectomy, Percutaneous / Q000379:methods*; D004724:Endoscopy / Q000009:adverse effects* / Q000379:methods*; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology; D011446:Prospective Studies; D016896:Treatment Outcome
keywords: Damages; Lumbar discectomy; Open excision; Percutaneous endoscopic; Tissue factors