title: WINROP can modify ROP screening praxis: a validation of WINROP in populations in Sörmland and Västmanland.
abstract: BACKGROUND
  This study validates the newly developed WINROP algorithm aimed at detecting retinopathy of prematurity (ROP) requiring treatment at an early stage. The study was conducted at two middle-sized hospitals in Sweden, prospectively and retrospectively.
  
  
  METHODS
  A total of 104 children participated in this study. Their mean gestational age at birth was 28.7 weeks (range, 23.6-32.1 weeks), and their mean birth weight was 1208 g (range, 477-2340 g). Weekly weight measurements were used in WINROP to calculate the risk of developing ROP.
  
  
  RESULTS
  80% of infants (83/104) had no ROP, 15% (16/104) had mild ROP (stage 1 or 2), 5% (5/104) had severe ROP, and 2% (2/104) were treated for ROP. The alarm was registered at an average of 2 weeks postnatal age (range 1-6 weeks).
  
  
  CONCLUSIONS
  WINROP identified all the infants at risk for developing stage 3 ROP (100% sensitivity) and had a 59% specificity. The alarm was registered several weeks before screening for ROP began. WINROP can be used to complement conventional ROP screening.
authors.affiliation: Ophthalmology Department, Västmanland Hospital in Västerås, Västerås, Sweden.
authors.forename: Laila
authors.initials: L
authors.lastname: Eriksson
authors.affiliation: Ophthalmology Department, Mälarsjukhuset in Eskilstuna, Eskilstuna, Sweden.
authors.forename: Ulrika
authors.initials: U
authors.lastname: Lidén
authors.affiliation: Sahlgrenska Academy at University of Gothenburg, Institute of Neuroscience and Physiology, Gothenburg, Sweden.
authors.forename: Chatarina
authors.initials: C
authors.lastname: Löfqvist
authors.affiliation: Sahlgrenska Academy at University of Gothenburg, Institute of Neuroscience and Physiology, Gothenburg, Sweden.
authors.forename: Ann
authors.initials: A
authors.lastname: Hellström
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D001724:Birth Weight; D003941:Diagnostic Techniques, Ophthalmological; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015997:Neonatal Screening; D011446:Prospective Studies; D012171:Retinal Vessels / Q000473:pathology*; D012178:Retinopathy of Prematurity / Q000175:diagnosis* / Q000628:therapy; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013548:Sweden
chemical_list: D015415:Biomarkers; D007334:Insulin-Like Growth Factor I
keywords: Child Health (paediatrics); Retina; Vision