title: Absence of antibodies against Bordetella pertussis in pregnant women and newborns in the state of Nuevo Leon.
abstract: OBJECTIVE
  To assess placental transfer of antibodies to the child at birth and at 2 months of age.
  
  
  METHODS
  For the quantification of anti-PT IgG antibodies, we used an indirect enzyme-linked immunosorbent assay standardized by The National Institute of Epidemiologic Diagnosis and Reference (InDRE). Samples were considered negative from 0 to 48 IU/mL, indeterminate from 49 to 93 IU/mL and positive at ≥94 IU/mL. We performed a cross-sectional assessment of anti-PT IgG antibody levels in the mother, umbilical cord, and child.
  
  
  RESULTS
  There was a higher concentration of IgG anti-TP in the umbilical cord (4.3%) and in the mother (1.4%), but a total absence was observed in the child (0%).
  
  
  CONCLUSIONS
  The vulnerability of children to Bordetella pertussis shows the need to implement effective immunization strategies, whether actively, in the child, or passively through the mother, adolescents, and adults who are in contact with the child.
authors.forename: Jesús Zacarías
authors.initials: JZ
authors.lastname: Villarreal-Pérez
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Ramírez-Aranda
authors.forename: Irasema
authors.initials: I
authors.lastname: Rodríguez-Rodríguez
authors.forename: José
authors.initials: J
authors.lastname: Perales-Dávila
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: García-Elizondo
authors.forename: Celina
authors.initials: C
authors.lastname: Gómez-Gómez
authors.forename: Edgar
authors.initials: E
authors.lastname: Galindo-Galindo
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Rodríguez-Moreno
authors.forename: Romelia
authors.initials: R
authors.lastname: Ballesteros-Elizondo
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001886:Bordetella pertussis / Q000276:immunology*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008800:Mexico; D011247:Pregnancy / Q000276:immunology*; D014917:Whooping Cough / Q000276:immunology* / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G