title: Optimal fabrication of nanofiber membranes from ionized-bicomponent cellulose/polyethyleneoxide solutions.
abstract: The effect of cellulose acetate (CA)/polyethyleneoxide (PEO) ratio (0.5-1.5 wt%) and lithium chloride (LiCl) content (0.25-0.75%, w/v) on the viscosity, surface tension and electrical conductivity (EC) of the solutions and diameter of the fabricated nanofiber membranes (NFMs) were optimized using response surface methodology-central composite rotatable design (RSM-CCRD). The NFMs were composed of non-woven fibers with maximum diameter of 121.70 ± 33.40. Second-order polynomial models with high R(2) values (0.977-0.998) were developed using multiple linear regression analysis. Results showed that the NFMs diameter and morphology were significantly affected by CA and LiCl contents (p<0.0001). The overall optimum region was found to be at the combined level of CA to PEO ratio of 1.5 wt% and LiCl content of 0.5% (w/v). At the optimum point, the viscosity, surface tension, EC and diameter were 0.425 ± 0.036 Pas, 36.21 ± 1.25 mN/m, 0.383 ± 0.014 ms/cm, and 82.19 ± 3.01 nm, respectively. The most uniform and bead-free NFMs were fabricated from the solution formulated with 1 wt% CA/PEO and 0.85% (w/v) of LiCl content.
authors.affiliation: Transfer Phenomena Laboratory (TPL), Department of Food Science, Technology and Engineering, Faculty of Agricultural Engineering and Technology, University College of Agriculture and Natural Resources, University of Tehran, 31587-11167 Karadj, Iran.
authors.forename: Atefeh
authors.initials: A
authors.lastname: Broumand
authors.affiliation: Transfer Phenomena Laboratory (TPL), Department of Food Science, Technology and Engineering, Faculty of Agricultural Engineering and Technology, University College of Agriculture and Natural Resources, University of Tehran, 31587-11167 Karadj, Iran. Electronic address: emamj@ut.ac.ir.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Emam-Djomeh
authors.affiliation: Transfer Phenomena Laboratory (TPL), Department of Food Science, Technology and Engineering, Faculty of Agricultural Engineering and Technology, University College of Agriculture and Natural Resources, University of Tehran, 31587-11167 Karadj, Iran.
authors.forename: Farmarz
authors.initials: F
authors.lastname: Khodaiyan
authors.affiliation: Nanotechnology Laboratory, Department of Nanotechnology, Agricultural Biotechnology Research Institute of Iran, Karadj, Iran.
authors.forename: Daryoush
authors.initials: D
authors.lastname: Davoodi
authors.affiliation: Department of Biotechnology, Research Center of Medical Plant-ACECR, Karadj, Iran.
authors.forename: Sasan
authors.initials: S
authors.lastname: Mirzakhanlouei
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004553:Electric Conductivity; D018021:Lithium Chloride / Q000737:chemistry; D057139:Nanofibers / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry*; D013500:Surface Tension; D014783:Viscosity
chemical_list: D012996:Solutions; C005062:acetylcellulose; D011092:Polyethylene Glycols; D002482:Cellulose; D018021:Lithium Chloride
keywords: Cellulose acetate; Electrospinning; Lithium chloride; Nanofiber; Optimization; Polyethyleneoxide