title: Synthesis of new β(2,2)-amino acids with carbohydrate side chains: impact on the synthesis of peptides.
abstract: The study describes the synthesis of new geminally disubstituted C-linked carbo-β(2,2)-amino acids (β(2,2)-Caas) with different carbohydrate side chains, and their use in the synthesis of β(2,2)-peptides. The study infers that the side chain has an influence on the synthesis of peptides and their conformational behaviour.
authors.affiliation: Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India. Electronic address: esmvee@iict.res.in.
authors.forename: Gangavaram V M
authors.initials: GV
authors.lastname: Sharma
authors.affiliation: Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Karnekanti
authors.initials: K
authors.lastname: Rajender
authors.affiliation: Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Gattu
authors.initials: G
authors.lastname: Sridhar
authors.affiliation: Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Post Sai
authors.initials: PS
authors.lastname: Reddy
authors.affiliation: Organic and Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, India.
authors.forename: Marumudi
authors.initials: M
authors.lastname: Kanakaraju
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D002241:Carbohydrates / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis*; D017510:Protein Folding; D055550:Protein Stability; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D010455:Peptides
keywords: Carbohydrate side chain; Geminally disubstituted; β(2,2)-Amino acids; β(2,2)-Peptides