title: Chemical composition, biological and cytotoxic activities of plant extracts and compounds isolated from Ferula lutea.
abstract: The present work describes the phytochemical study on Ferula lutea flowers. Total phenolics and flavonoids of the n-butanol and ethyl acetate extracts were quantified (phenolics [40.68-52.29 mg gallic acid equivalent/g of dry weight], flavonoids [12.38-14.72 mg quercitin/g dry weight]). Two diastereoisomers were isolated and identified using spectroscopic techniques (1D, 2D NMR and GC-MS). The extracts and diastereoisomers were tested for antioxidant, antiacetylcholinesterase, antimicrobial, antidiabectic, cytotoxic (leukemia cell line) activities and allelopathic potentialities. The strongest antioxidant activity was obtained for the ethyl acetate extract (IC₅₀ = 12.8 ± 1.29 µg/mL). The two extracts exhibited high antidiabetic activity (54.1 and 52.1% at 40 µg/mL).
authors.affiliation: Laboratoire des IMRCP UMR CNRS 5623, Faculté de pharmacie de Toulouse, Université de Toulouse, Université Paul-Sabatier, 118 route de Narbonne, Toulouse F-31062, France.
authors.forename: Mansour
authors.initials: M
authors.lastname: Znati
authors.affiliation: Laboratoire de Chimie Hétérocyclique, Produits Naturels et Réactivité (CHPNR), Equipe Chimie Médicinale et Produits Naturels, Département de Chimie, Faculté des Sciences de Monastir, Université de Monastir, Avenue de l'Environnement, Monastir 5019, Tunisia. hichem.benjannet@yahoo.fr.
authors.forename: Ben Jannet
authors.initials: BJ
authors.lastname: Hichem
authors.affiliation: Laboratoire des IMRCP UMR CNRS 5623, Faculté de pharmacie de Toulouse, Université de Toulouse, Université Paul-Sabatier, 118 route de Narbonne, Toulouse F-31062, France.
authors.forename: Sylvie
authors.initials: S
authors.lastname: Cazaux
authors.affiliation: Laboratoire des IMRCP UMR CNRS 5623, Faculté de pharmacie de Toulouse, Université de Toulouse, Université Paul-Sabatier, 118 route de Narbonne, Toulouse F-31062, France. jalloul.bouajila@univ-tlse3.fr.
authors.forename: Jalloul
authors.initials: J
authors.lastname: Bouajila
mesh_terms: D000890:Anti-Infective Agents; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D005309:Ferula / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry; D007004:Hypoglycemic Agents; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry; D010675:Pheromones; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D007004:Hypoglycemic Agents; D010636:Phenols; D010675:Pheromones; D010936:Plant Extracts