title: [The MAP kianase cascade. A key target for treatments in skin cancerology].
abstract: Intracellular mitogen-activated protein kinases (MAPK) form a signalling cascade of proteins involved in cell proliferation, differentiation, migration and apoptosis. They are particularly activated by some cytokines, hormones, environmental stress and in skin cancers as well. A series of pharmacological compounds targeting the MAPK cascade dramatically changes skin cancerology, at least during a transient phase of the metastatic process. Some combined treatments possibly increase the median overall survival.
authors.affiliation: Laboratoire LABIC, Université de Liege, France.
authors.forename: G E
authors.initials: GE
authors.lastname: Piérard
authors.affiliation: Unilab Lg, Service de Dermatopathologie, CHU de Liege.
authors.forename: C
authors.initials: C
authors.lastname: Piérard-Franchimont
authors.affiliation: Unilab Lg, Service de Dermatopathologie, CHU de Liege.
authors.forename: B
authors.initials: B
authors.lastname: Leonard
authors.affiliation: Unilab Lg, Service de Dermatopathologie, CHU de Liege.
authors.forename: P
authors.initials: P
authors.lastname: Delvenne
mesh_terms: D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000502:physiology*; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D048493:Proto-Oncogene Proteins B-raf; D020928:Mitogen-Activated Protein Kinases