title: [Risk factors in metachronous liver metastasis from gastric cancer].
abstract: OBJECTIVE
  To explore the clinicopathological characteristics and related risk factors in metachronous liver metastasis of gastric cancer.
  
  
  METHODS
  Clinical data of 115 patients with metachronous liver metastasis in Tianjin Medical University Cancer Institute and Hospital between 1996 and 2008 were analyzed retrospectively.
  
  
  RESULTS
  Among 115 patients, the 1-, 3- and 5-year non-hepatic metastasis rates were 45.3%, 14.8% and 3.5% respectively. Univariate Log-rank test indicated that location, tumor size, tumor differentiation, depth of invasion, lymph node metastasis, vascular invasion, nervous invasion, soft tissue invasion, and modes of gastrectomy were significant factors associated with hepatic metastasis after radical gastrectomy. On multivariate analysis, the size of gastric cancer, vascular invasion, tumor differentiation, and lymph node metastasis were independent factors associated with metachronous liver metastasis of gastric cancer.
  
  
  CONCLUSIONS
  The size of gastric cancer, vascular invasion, tumor differentiation and lymph node metastasis are important factors associated with the risk of hepatic metastasis from gastric cancer in patients after radical gastrectomy.
authors.affiliation: Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China. tjzhangrp@gmail.com.
authors.forename: Weijia
authors.initials: W
authors.lastname: Wang
authors.forename: Rupeng
authors.initials: R
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Jingyu
authors.initials: J
authors.lastname: Deng
authors.forename: Xuejun
authors.initials: X
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xue
authors.forename: Han
authors.initials: H
authors.lastname: Liang
mesh_terms: D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008207:Lymphatic Metastasis; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology* / Q000628:therapy