title: Oral postdialysis cholecalciferol supplementation in patients on maintenance hemodialysis: a dose-response approach.
abstract: The aim of the present study was to evaluate the dose of postdialysis cholecalciferol needed to maintain the 25-hydroxyvitamin D [25(OH)D] levels in the optimal range of 75-150 nmol/L. Twenty-six patients who had low baseline 25(OH)D levels (mean 27.5 ± 14.9 nmol/L) were studied. The 25(OH)D levels were measured every 2 months for one year. During the first two months, all the patients received 2000 IU of cholecalciferol after each hemodialysis (=6000 IU/wk). Thereafter, the dose was individualized and adapted every 2 months by administering 1 to 6 cholecalciferol tablets (2000 IU each) per week (total weekly dose = 2000-12000 IU/wk). During cholecalciferol supplementation, the 25(OH)D concentrations rapidly increased from baseline to 140.1 ± 28.3 nmol/L at month 6 and 95.6 ± 20.9 nmol/L at month 12. At month twelve, 86% of the patients had 25(OH)D levels within the target range with a mean dose of 5917 ± 4106 IU/wk of cholecalciferol; however, the amount needed to maintain these levels varied widely from 0 (n = 2) to 12000 IU/wk (n = 5). In conclusion, postdialysis cholecalciferol prescription is quite effective in correcting vitamin D deficiency/insufficiency, but the amount of cholecalciferol needed to maintain the 25(OH)D levels within the optimal range over the long-term varies widely among patients and must be individualized.
authors.affiliation: Service of Nephrology, HFR Hôpital Cantonal, 1708 Fribourg, Switzerland.
authors.forename: Eric
authors.identifier: 0000-0002-9307-3246
authors.initials: E
authors.lastname: Descombes
authors.affiliation: Central Laboratory, HFR Hôpital Cantonal, 1708 Fribourg, Switzerland.
authors.forename: Benoit
authors.initials: B
authors.lastname: Fellay
authors.affiliation: Service of Nephrology, HFR Hôpital Cantonal, 1708 Fribourg, Switzerland.
authors.forename: Ould Maouloud
authors.initials: OM
authors.lastname: Hemett
authors.affiliation: Central Laboratory, HFR Hôpital Cantonal, 1708 Fribourg, Switzerland.
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Magnin
authors.affiliation: Service of Nephrology, HFR Hôpital Cantonal, 1708 Fribourg, Switzerland.
authors.forename: Gilbert
authors.initials: G
authors.lastname: Fellay