title: Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project.
abstract: OBJECTIVE
  To explore associations between serum 25-hydroxyvitamin D (25(OH)D) levels and a wide range of health conditions, physical performance measures, disability, and mortality in a large epidemiological study to identify an optimum range for 25(OH)D concentrations.
  
  
  METHODS
  Cross-sectional study, with additional prospective data on falls and mortality.
  
  
  METHODS
  Concord Health and Ageing in Men Project, Sydney, Australia.
  
  
  METHODS
  Community-dwelling men aged 70 and older (N = 1,659).
  
  
  METHODS
  Serum 25(OH)D levels, general health status, self-reported diseases, physical performance measures, disability (activities of daily living and instrumental activities of daily living) and falls.
  
  
  RESULTS
  Fair, poor, and very poor health; self-reported diabetes mellitus; hyperglycemia; depression; muscle weakness; poor balance; and all-cause mortality were all associated with serum 25(OH)D levels less than 50 nmol/L, even after adjustment for confounding. The findings also suggest that, in older men, for a wide range of health conditions, physical performance measures, disability, falls, and mortality, the optimum range of 25(OH)D is between 50.0 and 74.9 nmol/L, with no additional benefit for 25(OH)D levels of 75.0 nmol/L or greater.
  
  
  CONCLUSIONS
  Programs aimed at achieving an optimum range of serum 25(OH)D at levels between 50.0 and 74.9 nmol/L may have overall health benefits and such levels are adequate for older men.
authors.affiliation: Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, New South Wales, Australia; School of Public Health, University of Sydney, Sydney, New South Wales, Australia.
authors.forename: Vasant
authors.initials: V
authors.lastname: Hirani
authors.forename: Robert G
authors.initials: RG
authors.lastname: Cumming
authors.forename: Vasi
authors.initials: V
authors.lastname: Naganathan
authors.forename: Fiona
authors.initials: F
authors.lastname: Blyth
authors.forename: David G
authors.initials: DG
authors.lastname: Le Couteur
authors.forename: David J
authors.initials: DJ
authors.lastname: Handelsman
authors.forename: Louise M
authors.initials: LM
authors.lastname: Waite
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Seibel
mesh_terms: D000058:Accidental Falls / Q000401:mortality / Q000706:statistics & numerical data*; D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D003430:Cross-Sectional Studies; D006233:Persons with Disabilities; D006304:Health Status; D006801:Humans; D015994:Incidence; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009517:New South Wales / Q000453:epidemiology; D011446:Prospective Studies; D015996:Survival Rate / Q000639:trends; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000097:blood / Q000453:epidemiology / Q000534:rehabilitation*
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D
keywords: Australia; Sydney; health outcomes; older men; population study; vitamin D levels