title: Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia.
abstract: OBJECTIVE
  Hyperphagia is a central feature of inherited disorders (e.g., Prader-Willi Syndrome) in which obesity is a primary phenotypic component. Hyperphagia may also contribute to obesity as observed in the general population, thus raising the potential importance of common underlying mechanisms and treatments. Substantial gaps in understanding the molecular basis of inherited hyperphagia syndromes are present as are a lack of mechanistic of mechanistic targets that can serve as a basis for pharmacologic and behavioral treatments.
  
  
  METHODS
  International conference with 28 experts, including scientists and caregivers, providing presentations, panel discussions, and debates.
  
  
  RESULTS
  The reviewed collective research and clinical experience provides a critical body of new and novel information on hyperphagia at levels ranging from molecular to population. Gaps in understanding and tools needed for additional research were identified.
  
  
  CONCLUSIONS
  This report documents the full scope of important topics reviewed at a comprehensive international meeting devoted to the topic of hyperphagia and identifies key areas for future funding and research.
authors.affiliation: Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.
authors.forename: Steven B
authors.initials: SB
authors.lastname: Heymsfield
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Avena
authors.forename: Leslie
authors.initials: L
authors.lastname: Baier
authors.forename: Phillip
authors.initials: P
authors.lastname: Brantley
authors.forename: George A
authors.initials: GA
authors.lastname: Bray
authors.forename: Lisa C
authors.initials: LC
authors.lastname: Burnett
authors.forename: Merlin G
authors.initials: MG
authors.lastname: Butler
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Driscoll
authors.forename: Dieter
authors.initials: D
authors.lastname: Egli
authors.forename: Joel
authors.initials: J
authors.lastname: Elmquist
authors.forename: Janice L
authors.initials: JL
authors.lastname: Forster
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Goldstone
authors.forename: Linda M
authors.initials: LM
authors.lastname: Gourash
authors.forename: Frank L
authors.initials: FL
authors.lastname: Greenway
authors.forename: Joan C
authors.initials: JC
authors.lastname: Han
authors.forename: James G
authors.initials: JG
authors.lastname: Kane
authors.forename: Rudolph L
authors.initials: RL
authors.lastname: Leibel
authors.forename: Ruth J F
authors.initials: RJ
authors.lastname: Loos
authors.forename: Ann O
authors.initials: AO
authors.lastname: Scheimann
authors.forename: Christian L
authors.initials: CL
authors.lastname: Roth
authors.forename: Randy J
authors.initials: RJ
authors.lastname: Seeley
authors.forename: Val
authors.initials: V
authors.lastname: Sheffield
authors.forename: Maïthé
authors.initials: M
authors.lastname: Tauber
authors.forename: Christian
authors.initials: C
authors.lastname: Vaisse
authors.forename: Liheng
authors.initials: L
authors.lastname: Wang
authors.forename: Robert A
authors.initials: RA
authors.lastname: Waterland
authors.forename: Rachel
authors.initials: R
authors.lastname: Wevrick
authors.forename: Jack A
authors.initials: JA
authors.lastname: Yanovski
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Zinn
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D016739:Behavior, Addictive; D003397:Craniopharyngioma / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D004435:Eating; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D006963:Hyperphagia / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D008297:Male; D023421:Models, Animal; D009765:Obesity / Q000150:complications / Q000517:prevention & control*; D016017:Odds Ratio; D010641:Phenotype; D011218:Prader-Willi Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D012097:Repressor Proteins / Q000378:metabolism; D012106:Research; D012528:Satiety Response
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D012097:Repressor Proteins; C491094:SIM1 protein, human