title: [In vitro derivation and characterization of a colorectal cancer stem cell subpopulation].
abstract: In present publication we describe for the first time the obtainment of cancer stem cells from a weakly metastatic human colorectal carcinoma cell line MIP101 via selecting from the native population the cells that express intensively an embryonic stem cell marker, POU5F1 (Oct4). We provide the evidence that these cells possess an elevated clonogenic and tumorigenic potential when compared to the native population, and this correlates to the hypothesis of cancer stem cells' primary role in the development of malignant neoplasms.
authors.forename: A P
authors.initials: AP
authors.lastname: Davydov-Sinitsyn
authors.forename: O V
authors.initials: OV
authors.lastname: Bazhenova
authors.forename: M A
authors.initials: MA
authors.lastname: Liskovykh
authors.forename: L L
authors.initials: LL
authors.lastname: Chechik
authors.forename: C V
authors.initials: CV
authors.lastname: Ponomartsev
authors.forename: A N
authors.initials: AN
authors.lastname: Tomilin
authors.forename: E N
authors.initials: EN
authors.lastname: Tolkunova
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D045744:Cell Line, Tumor; D019070:Cell Lineage / Q000235:genetics; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D053595:Embryonic Stem Cells / Q000166:cytology* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000166:cytology* / Q000378:metabolism; D050814:Octamer Transcription Factor-3 / Q000096:biosynthesis*
chemical_list: D014408:Biomarkers, Tumor; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human