title: Population-based epidemiology of postoperative venous thromboembolism in Taiwanese patients receiving hip or knee arthroplasty without pharmacological thromboprophylaxis.
abstract: BACKGROUND
  Population-based evaluation on the incidence of postoperative venous thromboembolism (VTE) has not yet been reported for Asians receiving arthroplasty. In Taiwan, thromboprophylaxis was not commonly applied for patients. The population-based cohort study aimed to investigate the epidemiology, and to determine the risk factors VTE for patients receiving hip or knee replacement without pharmacological thromboprophylaxis in Taiwan.
  
  
  METHODS
  We retrospectively acquired patients' data from National Health Insurance databases representing more than 99% of about 23 million Taiwanese citizens. The primary outcome was the incidence of composite symptomatic VTE within 28d ays after receiving hip or knee replacement surgery.
  
  
  RESULTS
  During 2002 to 2006, there were 114,026 patients undergoing hip (n=61,460) or knee (n=52,566) replacement surgery. The occurrence rate of overall postoperative VTE was 0.44%. The incidence of pulmonary embolism was four in 10,000 patients receiving hip replacement or seven in 10,000 individuals undergoing knee replacement. The weekly cumulative incidence of VTE was persistently rising up to 28 days after surgery. Dramatic increase in risk of post-surgical VTE was associated with prior disease history of PE (p<0.001 for hip replacement, p=0.01 for knee replacement) or DVT (p=0.004 for hip replacement, p<0.001 for knee replacement). Prior claim of congestive heart failure was an independent risk factor associated with patients receiving knee arthroplasty (p=0.01).
  
  
  CONCLUSIONS
  Life-threatening PE occurred and increased cumulatively up to 28 days after hip or knee arthroplasty in Asians. Proper prophylaxis for patients with the exposure of high risks needs to be scrutinized.
authors.affiliation: Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Orthropaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Orthopaedic Department School of Medicine, National Yang-Ming University. Electronic address: drwuvgh@gmail.com.
authors.forename: Po-Kuei
authors.initials: PK
authors.lastname: Wu
authors.affiliation: Department of Orthropaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Orthopaedic Department School of Medicine, National Yang-Ming University.
authors.forename: Cheng-Fong
authors.initials: CF
authors.lastname: Chen
authors.affiliation: Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Orthopaedic Department School of Medicine, National Yang-Ming University; Department of Orthropaedics and Traumatology, Chia-Yi Christian Hospital, Chia-Yi, Taiwan, ROC.
authors.forename: Lien-Hsiang
authors.initials: LH
authors.lastname: Chung
authors.affiliation: Department of Orthropaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Orthopaedic Department School of Medicine, National Yang-Ming University.
authors.forename: Chien-Lin
authors.initials: CL
authors.lastname: Liu
authors.affiliation: Department of Orthropaedics and Traumatology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Orthopaedic Department School of Medicine, National Yang-Ming University. Electronic address: ciaoquess@gmail.com.
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects / Q000706:statistics & numerical data*; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects / Q000706:statistics & numerical data*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000009:adverse effects / Q000706:statistics & numerical data*; D011183:Postoperative Complications / Q000453:epidemiology; D011184:Postoperative Period; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D054556:Venous Thromboembolism / Q000453:epidemiology* / Q000209:etiology
keywords: Deep vein thrombosis; Pulmonary embolism; THR; TKA; Venous thromboembolism