title: Transarterial treatment of colorectal cancer liver metastases with irinotecan-loaded drug-eluting beads: technical recommendations.
abstract: Transcatheter hepatic arterial administration of irinotecan-loaded drug-eluting beads (DEBIRI) is used to treat liver-only or liver-dominant metastatic disease from colorectal cancer (CRC). Eligibility for DEBIRI should be established in each individual patient by a multidisciplinary team based on comprehensive clinical, imaging, and laboratory assessment. Standardization of DEBIRI technique and protocols would be expected to lead to improved efficacy and safety. The present article provides a set of technical recommendations for the use of DEBIRI in the treatment of hepatic CRC metastases.
authors.affiliation: Division of Diagnostic Imaging and Intervention, Pisa University School of Medicine, Pisa, Italy. Electronic address: riccardo.lencioni@med.unipi.it.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Lencioni
authors.affiliation: Interventional Oncology Unit, Istituto Oncologico Veneto, Padua, Italy.
authors.forename: Camillo
authors.initials: C
authors.lastname: Aliberti
authors.affiliation: Department of Interventional Radiology, Institut Gustav Roussy, Villejuif, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: de Baere
authors.affiliation: Department of Radiology, Hospital Italiano, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Garcia-Monaco
authors.affiliation: Division of Vascular Interventional Radiology, University of Miami Miller School of Medicine, Miami, Florida.
authors.forename: Govindarajan
authors.initials: G
authors.lastname: Narayanan
authors.affiliation: Department of Radiology, University Hospital Aintree, Liverpool, United Kingdom.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: O'Grady
authors.affiliation: Division of Vascular and Interventional Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin.
authors.forename: William S
authors.initials: WS
authors.lastname: Rilling
authors.affiliation: Department of Radiology, Wesley Hospital, Auchenflower, Australia.
authors.forename: Duncan
authors.initials: D
authors.lastname: Walker
authors.affiliation: Division of Surgical Oncology, University of Louisville, Louisville, Kentucky.
authors.forename: Robert C G
authors.initials: RC
authors.lastname: Martin
mesh_terms: D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D016461:Chemoembolization, Therapeutic / Q000592:standards*; D015179:Colorectal Neoplasms / Q000628:therapy*; D003692:Delayed-Action Preparations / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004358:Drug Therapy / Q000592:standards; D054855:Drug-Eluting Stents / Q000592:standards*; D006801:Humans; D007269:Injections, Intra-Arterial / Q000592:standards; D038622:Internationality; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D017410:Practice Guidelines as Topic
chemical_list: D003692:Delayed-Action Preparations; D000077146:Irinotecan; D002166:Camptothecin