title: The role of transperineal template prostate biopsies in prostate cancer diagnosis in biopsy naïve men with PSA less than 20 ng ml(-1.).
abstract: BACKGROUND
  To compare prostate cancer detection rates between transrectal ultrasound (TRUS) prostate biopsy and transperineal template prostate biopsy (TPTPB) in biopsy naïve men. TRUS biopsy is still regarded as gold standard for prostate cancer diagnosis. TPTPB has been shown to improve prostate cancer detection in men with rising PSA and previous negative TRUS biopsies. We carried out a prospective study performing both biopsies in the same group of men with a benign feeling digital rectal examination (DRE), PSA <20 ng ml(-1) and no previous prostate biopsies.
  
  
  METHODS
  A total of 50 patients with mean age of 67 years (range: 54-84), mean prostate volume 58 cc (range: 19-165) and mean PSA 8 ng l(-1) (range: 4-18) underwent standard 12-core TRUS biopsy followed immediately by 36-core TPTPB under general anaesthetic. We determined the prostate cancer detection rate between the two diagnostic modalities.
  
  
  RESULTS
  In total, 20/50 (40%) had benign pathology. Of 30/50 (60%) diagnosed with prostate cancer, 16 (32%) had positive results in both TRUS and TPTPB, whereas 14 (28%) had negative TRUS but positive TPTPB. No cancers were detected solely by TRUS biopsy. TRUS biopsy detected cancer in 32% versus 60% with TPTPB. In total, 19/30(63%) cancers detected by TPTPB had Gleason score > or =7.2 (4%) experienced urosepsis, 7 (14%) temporary urinary retention, 16 (32%) mild haematuria and 19 (38%) haematospermia.
  
  
  CONCLUSIONS
  TPTPB is associated with significantly higher prostate cancer detection rate than TRUS biopsies in biopsy naïve men with a benign feeling DRE and PSA <20 ng ml(-1). PSA appears to be better biomarker than previously thought.
authors.affiliation: Department of Urology, Leicester General Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK.
authors.forename: S
authors.initials: S
authors.lastname: Nafie
authors.affiliation: Department of Urology, Leicester General Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK.
authors.forename: J K
authors.initials: JK
authors.lastname: Mellon
authors.affiliation: Department of Cellular Pathology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Dormer
authors.affiliation: Department of Urology, Leicester General Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK.
authors.forename: M A
authors.initials: MA
authors.lastname: Khan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D051517:Digital Rectal Examination / Q000379:methods; D006801:Humans; D007610:Kallikreins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*
chemical_list: C549870:KLK3 protein, human; D007610:Kallikreins; D017430:Prostate-Specific Antigen