title: Copper-catalyzed carboxamide-directed ortho amination of anilines with alkylamines at room temperature.
abstract: In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.
authors.affiliation: Department of Chemistry, The Pennsylvania State University , University Park, Pennsylvania 16802, United States.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Li
authors.forename: Shu-Yu
authors.initials: SY
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: He
authors.forename: Zhaoyan
authors.initials: Z
authors.lastname: Ai
authors.forename: William A
authors.initials: WA
authors.lastname: Nack
authors.forename: Gong
authors.initials: G
authors.lastname: Chen
mesh_terms: D000577:Amides / Q000737:chemistry*; D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D013696:Temperature
chemical_list: D000577:Amides; D000814:Aniline Compounds; D003300:Copper