title: Exercise training improves cardiac autonomic nervous system activity in type 1 diabetic children.
abstract: [Purpose] We investigated the effect exercise training has on cardiac autonomic nervous system (ANS) and cardiovascular risk profiles in children with type 1 diabetes mellitus (DM). [Subjects] Fifteen type 1 DM children (all boys; 13.0±1.0 years of age) were enrolled in the study. [Methods] The subjects received exercise training three times a week in a 12-week program. Each child was asked to walk on a treadmill to achieve an exercise intensity of VO2max 60%. ANS activity was measured by power spectral analysis of the electrocardiogram (ECG). Blood samples were obtained for serum lipid profiles. To evaluate Doppler-shifted Fourier pulsatility index (PI) analysis, a 5-MHz continuous wave Doppler (VASCULAB D10) set was used to measure forward blood flow velocity (FLOW) in the radial artery. [Results] Total and low-frequency (LF) power of heart rate variability increased significantly after exercise intervention. Total cholesterol (TC) levels were significant lower after exercise intervention. Total and high-frequency (HF) power were significantly correlated with higher TC levels, but diastolic blood pressure and HF was significantly correlated with lower TC levels. [Conclusion] Regular exercise intervention should be prescribed for children with type 1 DM.
authors.affiliation: Laboratory of Exercise Biochemistry, Department of Physical Education, Dong-A University, Republic of Korea.
authors.forename: Ki Ok
authors.initials: KO
authors.lastname: Shin
authors.affiliation: Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Japan.
authors.forename: Toshio
authors.initials: T
authors.lastname: Moritani
authors.affiliation: Laboratory of Exercise Physiology, Department of Physical Education, Dong-A University, Republic of Korea.
authors.forename: Jinhee
authors.initials: J
authors.lastname: Woo
authors.affiliation: Laboratory of Exercise Biochemistry, Department of Physical Education, Dong-A University, Republic of Korea.
authors.forename: Ki Soeng
authors.initials: KS
authors.lastname: Jang
authors.affiliation: Laboratory of Exercise Biochemistry, Department of Physical Education, Dong-A University, Republic of Korea.
authors.forename: Ju Yong
authors.initials: JY
authors.lastname: Bae
authors.affiliation: Division of Endocrinology and Metabolism, Department of Pediatrics, Medical Center, Dong-A University, Republic of Korea.
authors.forename: Jaeho
authors.initials: J
authors.lastname: Yoo
authors.affiliation: Laboratory of Exercise Physiology, Department of Physical Education, Dong-A University, Republic of Korea.
authors.forename: Sunghwun
authors.initials: S
authors.lastname: Kang
keywords: Autonomic nervous system; Diabetes mellitus; Exercise