title: Is prevention a realistic goal for schizophrenia?
abstract: Over the past 2 decades, increased efforts have focused on identifying those at genetic or clinical risk for psychosis and promoting interventions that may alter the onset or trajectory of schizophrenia. We review studies published between 2010-2013 that: (1) investigate at-risk states for psychosis in larger epidemiological studies; (2) identify causes of certain clinical presentations of the schizophrenia phenotype and (3) investigate focused and multidisciplinary approaches to treat early clinical symptoms. The article places these recent studies within the context of prior research and the concept of potential measures to prevent or ameliorate the onset of psychosis.
authors.affiliation: Schizophrenia Center, Department of Psychiatry, University of Pennsylvania School of Medicine, 10 Gates, 3400 Spruce Street, Philadelphia, PA, 19104, USA, kohler@upenn.edu.
authors.forename: Christian
authors.initials: C
authors.lastname: Kohler
authors.forename: Karin E
authors.initials: KE
authors.lastname: Borgmann-Winter
authors.forename: Irene
authors.initials: I
authors.lastname: Hurford
authors.forename: Eli
authors.initials: E
authors.lastname: Neustadter
authors.forename: James
authors.initials: J
authors.lastname: Yi
authors.forename: Monica E
authors.initials: ME
authors.lastname: Calkins
mesh_terms: D042241:Early Diagnosis; D006801:Humans; D011618:Psychotic Disorders / Q000175:diagnosis / Q000517:prevention & control* / Q000628:therapy; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*