title: Lack of association of the caspase-12 long allele with community-acquired pneumonia in people of African descent.
abstract: Community-acquired pneumonia (CAP) is a common cause of sepsis. Active full-length caspase-12 (CASP12L), confined to the people of African descent, has been associated with increased susceptibility to and mortality from severe sepsis. The objective of this study was to determine whether CASP12L was a marker for susceptibility and/or severity of CAP. We examined three CAP cohorts and two control populations: 241 adult Memphis African American CAP patients, 443 pediatric African American CAP patients, 90 adult South African CAP patients, 120 Memphis healthy adult African American controls and 405 adult Chicago African American controls. Clinical outcomes including mortality, acute respiratory distress syndrome (ARDS), septic shock or severe sepsis, need for mechanical ventilation, and S. pneumoniae bacteremia. Neither in the three individual CAP cohorts nor in the combined CAP cohorts, was mortality in CASP12L carriers significantly different from that in non-CASP12L carriers. No statistically significant association between genotype and any measures of CAP severity was found in any cohort. We conclude that the functional CASP12L allele is not a marker for susceptibility and/or severity of CAP.
authors.affiliation: Department of Medicine, Northwestern University, Chicago, Illinois, United States of America ; Section of Pulmonary, Critical Care, Sleep and Allergy, University of Illinois at Chicago, Chicago, Illinois, United States of America.
authors.forename: Jiwang
authors.initials: J
authors.lastname: Chen
authors.affiliation: Oakbrook Pediatrics, Summerville, South Carolina, United States of America.
authors.forename: Esther S
authors.initials: ES
authors.lastname: Wilson
authors.affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Dahmer
authors.affiliation: Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan, United States of America.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Quasney
authors.affiliation: Department of Medicine, Northwestern University, Chicago, Illinois, United States of America ; School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia.
authors.forename: Grant W
authors.initials: GW
authors.lastname: Waterer
authors.affiliation: Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital, and Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: Charles
authors.initials: C
authors.lastname: Feldman
authors.affiliation: Department of Medicine, Northwestern University, Chicago, Illinois, United States of America.
authors.forename: Richard G
authors.initials: RG
authors.lastname: Wunderink
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001483:Base Sequence; D044383:Black People; D016022:Case-Control Studies; D053454:Caspase 12 / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D017714:Community-Acquired Infections / Q000208:ethnology / Q000235:genetics*; D017931:DNA Primers; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D018410:Pneumonia, Bacterial / Q000208:ethnology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult; D001741:Black or African American
chemical_list: D017931:DNA Primers; D053454:Caspase 12