title: The effect of cell type on surgico-pathologic risk factors in endometrial cancer.
abstract: OBJECTIVE
  In this study the effect of histologic subtype as a surgicopathologic risk factor in endometrial cancer is evaluated.
  
  
  METHODS
  We evaluated 182 patients who underwent systematic lymphadenectomy up to the level of the renal vessels and at least 15 lymph nodes were dissected from the pelvic area and 10 lymph nodes from the para-aortic area. investigation of whether endometrioid and aggressive cell types (serous papillary cell and clear cell) affect the distribution of surgicopathologic risk factors among endometrial cancer cases was carried out.
  
  
  RESULTS
  Patients in the aggressive cell type group were older and the tumor size was significantly smaller. There was no difference between the two groups for the total number of dissected lymph nodes except for the external iliac area. Although the difference is not statistically significant, the total number of lymph nodes dissected in the aggressive group was less (54.3 vs 62.9, p=0.067) than that of the endometrioid cell type group. While the incidence of pelvic lymph node metastasis in the aggressive group was 59.1% the incidence was 15.6% in the endometrioid cell type group (p>0.001). The possibility of lymph node metastasis for aggressive cell type endometrial carcinoma in the para-aortic area was twice the endometrioid cell type group. It was found that the presence and type (stromal/glandular) of cervical invasion, depth of myometrial invasion and presence of lymphovascular space invasion were not affected by cell type.
  
  
  CONCLUSIONS
  Aggressive cell types significantly increase the adnexial and lymph node metastasis in endometrial cancer.
authors.affiliation: Department of Gynecologic Oncology, Etlik Zübeyde Hanım Women, Ankara, Turkey.
authors.forename: Ahmet Taner
authors.initials: AT
authors.lastname: Turan
authors.affiliation: Department of Gynecologic Oncology, Etlik Zübeyde Hanım Women, Ankara, Turkey.
authors.forename: Betül
authors.initials: B
authors.lastname: Dündar
authors.affiliation: Department of Gynecologic Oncology, Etlik Zübeyde Hanım Women, Ankara, Turkey.
authors.forename: Burcu
authors.initials: B
authors.lastname: Gündoğdu
authors.affiliation: Department of Gynecology and Obstetrics, Cumhuriyet University, Sivas, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Boztosun
authors.affiliation: Department of Gynecologic Oncology, Etlik Zübeyde Hanım Women, Ankara, Turkey.
authors.forename: Nejat
authors.initials: N
authors.lastname: Ozgül
authors.affiliation: Department of Gynecologic Oncology, Etlik Zübeyde Hanım Women, Ankara, Turkey.
authors.forename: Nurettin
authors.initials: N
authors.lastname: Boran
authors.affiliation: Department of Gynecologic Oncology, Etlik Zübeyde Hanım Women, Ankara, Turkey.
authors.forename: Gökhan
authors.initials: G
authors.lastname: Tulunay
authors.affiliation: Department of Pathology, Etlik Zübeyde Hanım Women, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ozfuttu
authors.affiliation: Department of Gynecologic Oncology, Etlik Zübeyde Hanım Women, Ankara, Turkey.
authors.forename: Mehmet Faruk
authors.initials: MF
authors.lastname: Köse
keywords: Endometrial carcinoma; cell type