title: [Molecular profiling of non-small cell lung cancer].
abstract: The management of locally advanced and metastatic non-small cell lung cancer has been revolutionized thanks to recent progress in pathology and molecular biology. The first molecular subgroup is defined by activating mutations of the epidermal growth factor receptor (EGFR), and a dramatic response to specific tyrosine kinase inhibitors. Since then, multiple genetic alterations (KRAS, HER2, BRAF, PIK3CA, ALK, ROS, RET…) have been identified as potential target of novel therapies, and molecular profiling has become common practice. This review focus on the molecular alterations associated with non-small cell lung cancer, including molecular profiling and response to targeted therapies.
authors.affiliation: Service de pathologie, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Gibault
authors.affiliation: Service de pathologie, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; Université Paris Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Cazes
authors.affiliation: Service de biochimie, UF de pharmacogénétique et oncologie moléculaire, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Narjoz
authors.affiliation: Université Paris Descartes, 12, rue de l'École-de-Médecine, 75006 Paris, France; Service de biochimie, UF de pharmacogénétique et oncologie moléculaire, hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, 20, rue Leblanc, 75015 Paris, France; UMR-S775, Inserm, centre universitaire des Saints-Pères, 46, rue des Saints-Pères, 75006 Paris, France. Electronic address: helene.blons@egp.aphp.fr.
authors.forename: H
authors.initials: H
authors.lastname: Blons
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics*; D003663:Decision Trees; D020869:Gene Expression Profiling; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics*; D058990:Molecular Targeted Therapy; D009154:Mutation
keywords: Adénocarcinomes du poumon; Biologie moléculaire; Molecular biology; Non-small cell lung cancer