title: The impact of metabolic syndrome on serum total testosterone level in patients with erectile dysfunction.
abstract: OBJECTIVE
  To determine the association between metabolic syndrome (MetS) and serum testosterone levels (TT) in patients with erectile dysfunction (ED).
  
  
  METHODS
  This study included 280 ED patients above 40-years-of-age. Participants were divided into two groups according to 2005 criteria of International Diabetes Federation. The severity of ED was determined according to the International Index of Erectile Function-EF (IIEF-EF score; 0-10 severe ED, 11-25 mild to moderate ED). The severity of ED, serum TT levels and other MetS components were compared between the groups.
  
  
  RESULTS
  The mean age of the patients was 55.7 ± 8.2 years. One hundred eighteen patients (%42.1) had MetS. Sixty-eight patients with MetS (57.6%) and 71 patients without MetS (43.8%) had severe ED (p = 0.031). A total of 46 (16.4%) patients had hypogonadism. Hypogonadism was seen more prevalent in patients with MetS (22.9% vs. 11.7%, p = 0.013). Logistic regression analyses for ED risk factors demonstrated that abnormal FBG increased the relative risk of severe ED up to 10.7-fold (p < 0.001) but not presence of hypogonadism (p = 0.706).
  
  
  CONCLUSIONS
  Metabolic syndrome was seen in almost half of the patients with ED. ED was more severe among MetS patients. Hypogonadism alone is a not risk factor for severe ED.
authors.affiliation: Department of Urology, Ankara Numune Research and Training Hospital, Ministry of Health , Ankara , Turkey and.
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Aslan
authors.forename: Ozer
authors.initials: O
authors.lastname: Guzel
authors.forename: Melih
authors.initials: M
authors.lastname: Balci
authors.forename: Altug
authors.initials: A
authors.lastname: Tuncel
authors.forename: Muslum
authors.initials: M
authors.lastname: Yildiz
authors.forename: Ali
authors.initials: A
authors.lastname: Atan
mesh_terms: D000328:Adult; D000368:Aged; D007172:Erectile Dysfunction / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D012720:Severity of Illness Index; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone
keywords: Erectile dysfunction; hypogonadism; male; metabolic syndrome; testosterone