title: [The study of the expression of TCR BV CDR3 family in fulminant hepatitis B patients].
abstract: OBJECTIVE
  To study the expression of TCR BV CDR3 family in fulminant hepatitis B (FHB) patients.
  
  
  METHODS
  Totally 28 patients with fulminant hepatitis B (FHB) (FHB group), who were treated in our hospital from Oct. 2010. to Mar. 2012, and 20 healthy controls( HC group) were included in the study. PBMCs were isolated from anticogulated blood, and RT-PCR was used to detect the levels of TCR BV CDR3 family in the 2 groups.
  
  
  RESULTS
  The levels of DeltaCt1, DeltaCt12 and DeltaCt20 in FHB group were higher than those in HC group (P < 0.05); The levels of DeltaCt5, DeltaCt7, DeltaCt13, DeltaCt14, DeltaCt15, DeltaCt22, DeltaCt23 in FHB group were lower than those in HC group (P < 0.05).
  
  
  CONCLUSIONS
  The result indicates that cellular immunology is involved in the pathogenesis of the liver inflammation process of FHB.
authors.affiliation: The Second People's Hospital of Lanzhou, 730046, China. swj7218@163.com
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Shi
authors.affiliation: The Second People's Hospital of Lanzhou, 730046, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wan
authors.affiliation: The Second People's Hospital of Lanzhou, 730046, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.affiliation: The Second People's Hospital of Lanzhou, 730046, China.
authors.forename: Li
authors.initials: L
authors.lastname: Wei
authors.affiliation: The Second People's Hospital of Lanzhou, 730046, China.
authors.forename: Zheng-Mao
authors.initials: ZM
authors.lastname: Yang
authors.affiliation: The Second People's Hospital of Lanzhou, 730046, China.
authors.forename: Zhao-Xun
authors.initials: ZX
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D022801:Complementarity Determining Regions / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D005260:Female; D006509:Hepatitis B / Q000235:genetics* / Q000276:immunology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D055815:Young Adult
chemical_list: D022801:Complementarity Determining Regions; D011948:Receptors, Antigen, T-Cell