title: G-protein-coupled receptor regulation of de novo purine biosynthesis: a novel druggable mechanism.
abstract: Spatial organization of metabolic enzymes may represent a general cellular mechanism to regulate metabolic flux. One recent example of this type of cellular phenomenon is the purinosome, a newly discovered multi-enzyme metabolic assembly that includes all of the enzymes within the de novo purine biosynthetic pathway. Our understanding of the components and regulation of purinosomes has significantly grown in recent years. This paper reviews the purine de novo biosynthesis pathway and its regulation, and presents the evidence supporting the purinosome assembly and disassembly processes under the control of G-protein-coupled receptor (GPCR) signaling. This paper also discusses the implications of purinosome and GPCR regulation in drug discovery.
authors.affiliation: a Biochemical Technologies, Science and Technology Division , Corning Incorporated , Corning , New York , USA.
authors.forename: Ye
authors.initials: Y
authors.lastname: Fang
authors.forename: Jarrod
authors.initials: J
authors.lastname: French
authors.forename: Hong
authors.initials: H
authors.lastname: Zhao
authors.forename: Stephen
authors.initials: S
authors.lastname: Benkovic
mesh_terms: D055808:Drug Discovery; D046911:Macromolecular Substances / Q000378:metabolism*; D011687:Purines / Q000096:biosynthesis* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D046911:Macromolecular Substances; D011687:Purines; D043562:Receptors, G-Protein-Coupled; C030985:purine