title: Chronic administration of 5-HT1A receptor agonist relieves depression and depression-induced hypoalgesia.
abstract: Previous studies have shown that depressed patients as well as animal models of depression exhibit decreased sensitivity to evoked pain stimuli, and serotonin is indicated to be involved in depression-induced hypoalgesia. The purpose of this study was to investigate the potential role of 5-HT1A receptor in the depression-induced hypoalgesia. Acute or chronic administration of 5-HT1A receptor agonist, 8-OH-DPAT, was performed in olfactory bulbectomy (OB) and sham-operated rats. The depression-like behavior and pain thresholds were measured using open-field test and radiant heat thermal pain test, respectively. We found that acute administration of 8-OH-DPAT increased locomotor activity and pain thresholds in the sham rats but had no effect on the OB rats. In contrast, chronic administration of 8-OH-DPAT reduced locomotor activity and pain thresholds and restored them to normal level. Increased pain thresholds were also observed in the sham rats after the chronic administration. These results demonstrated that chronic administration of 8-OH-DPAT reversed the depression-induced decrease in pain sensitivity in rats, suggesting that 5-HT1A receptor may play a role in the depression-associated hypoalgesia.
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China ; University of Chinese Academy of Sciences, Beijing 100039, China.
authors.forename: Zhao-Cai
authors.identifier: 0000-0003-3062-0844
authors.initials: ZC
authors.lastname: Jiang
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China ; Department of Psychology, Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100035, China.
authors.forename: Wei-Jing
authors.initials: WJ
authors.lastname: Qi
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Jin-Yan
authors.identifier: 0000-0002-7477-7547
authors.initials: JY
authors.lastname: Wang
authors.affiliation: Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
authors.forename: Fei
authors.identifier: 0000-0002-1662-928X
authors.initials: F
authors.lastname: Luo
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D006987:Hypesthesia / Q000188:drug therapy* / Q000209:etiology; D008124:Locomotion / Q000187:drug effects; D008297:Male; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D058825:Serotonin 5-HT1 Receptor Agonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D058825:Serotonin 5-HT1 Receptor Agonists; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin