title: The contribution of extrasynaptic signaling to cerebellar information processing.
abstract: The diversity of synapses within the simple modular structure of the cerebellum has been crucial for study of the phasic extrasynaptic signaling by fast neurotransmitters collectively referred to as "spillover." Additionally, the accessibility of cerebellar components for in vivo recordings and their recruitment by simple behaviors or sensory stimuli has allowed for both direct and indirect demonstrations of the effects of transmitter spillover in the intact brain. The continued study of spillover in the cerebellum not only promotes our understanding of information transfer through cerebellar structures but also how extrasynaptic signaling may be regulated and interpreted throughout the CNS.
authors.affiliation: Department of Neurobiology, McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
authors.forename: Luke T
authors.initials: LT
authors.lastname: Coddington
authors.forename: Angela K
authors.initials: AK
authors.lastname: Nietz
authors.forename: Jacques I
authors.initials: JI
authors.lastname: Wadiche
mesh_terms: D000818:Animals; D002531:Cerebellum / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D009412:Nerve Fibers / Q000502:physiology; D018377:Neurotransmitter Agents / Q000378:metabolism; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D018377:Neurotransmitter Agents