title: Conservative treatments, surgical treatments, and the KineSpring® Knee Implant system for knee osteoarthritis: a systematic review.
abstract: OBJECTIVE
  Knee osteoarthritis (OA) is a disease with a high global burden, and multiple treatment options are available. In the current review we summarize the results of studies that have evaluated treatments of knee OA, and we compare these results with an implantable load absorber called the KineSpring® Knee Implant System.
  
  
  METHODS
  We conducted a literature search of systematic reviews on treatment strategies for knee OA. We pooled results for each treatment in three categories: pain, function, and stiffness. Then we compared this data to that available for the KineSpring System.
  
  
  RESULTS
  Medications and viscosupplementation show promising initial pain relief for knee OA. Aerobic and resistance training, unicompartmental knee arthroplasty (UKA), and total knee arthroplasty (TKA) showed a reduction in pain scores. High tibial osteotomy (HTO) generally improves pain and function at 6 weeks, but long-term results are lacking. The KineSpring System demonstrated significant improvements from baseline to 24 months, but direct comparative data are lacking.
  
  
  CONCLUSIONS
  Evidence for knee OA therapies suggests improved pain, stiffness, and functional outcomes. Additional research is necessary to clearly delineate the advantages of various approaches to guide practice.
authors.affiliation: Global Research Solutions, Inc., Burlington, Ontario, Canada.
authors.forename: Chuan Silvia
authors.initials: CS
authors.lastname: Li
authors.affiliation: Division of Orthopaedic Surgery, Centre for Evidence-Based Orthopaedics, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Olufemi R
authors.initials: OR
authors.lastname: Ayeni
authors.affiliation: Division of Orthopaedic Surgery, Centre for Evidence-Based Orthopaedics, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Sheila
authors.initials: S
authors.lastname: Sprague
authors.affiliation: Global Research Solutions Inc, Burlington, Ontario, Canada.
authors.forename: Victoria
authors.initials: V
authors.lastname: Truong
authors.affiliation: CLARITY Research Group, McMaster University, Department of Orthopedic Surgery Musculoskeletal Research Unit, Canada and Division of Orthopaedic Surgery and Department of Clinical Epidemiology & Biostatistics, Hamilton General Hospital, Canada.
authors.forename: Mohit
authors.initials: M
authors.lastname: Bhandari
mesh_terms: D019645:Arthroplasty, Replacement, Knee; D006801:Humans; D007719:Knee Joint / Q000601:surgery; D007720:Knee Prosthesis; D020370:Osteoarthritis, Knee / Q000628:therapy*; D010147:Pain Measurement; D055675:Viscosupplements / Q000627:therapeutic use
chemical_list: D055675:Viscosupplements