title: Growth development of French children born after in vitro maturation.
abstract: BACKGROUND
  Several lines of evidence indicate that immature oocyte retrieval and subsequent in vitro maturation (IVM) without ovarian stimulation may be a reliable option in assisted reproductive technologies (ART). However, few outcome data are available for children born following this technique.
  
  
  OBJECTIVE
  We assessed height and weight development of French children conceived after IVM.
  
  
  METHODS
  All children conceived after IVM at Antoine Beclere Hospital (Clamart, France) and born between June 2003 and October 2008 (n = 38) were included in a prospective cohort study and compared with a control group of children conceived by ICSI without IVM, matched for maternal age, gestational age and singleton/twin pregnancies. Follow-up included clinical examination at one year and a questionnaire completed by parents when the children were two years old (97% follow-up rate).
  
  
  RESULTS
  No statistical differences between IVM and control groups were found for boys. Mean weight, height and head circumference at birth were significantly greater for IVM than for ICSI girls (3.236 kg vs 2.701 kg (p = 0.03); 49 cm vs 47 cm (p = 0.01) and 34 cm vs 33 cm (p = 0.04), respectively). At one year, IVM girls remained heavier (mean weight 10.2 kg vs 8.6 kg (p = 0.001)) and taller (76 cm vs 73 cm (p = 0.03)), and there was a two-point difference in BMI between the two groups of girls (18 vs 16 (p = 0.01)).
  
  
  CONCLUSIONS
  Our results in girls born after IVM should be interpreted with caution. It remains unclear whether the observed sexual dimorphism is due to IVM technology or to maternal characteristics such as underlying infertility in patients with polycystic ovary syndrome (PCOS). Further monitoring of the outcomes of these infants is required.
authors.affiliation: Epidemiological Research Unit on Perinatal Health and Women's and Children's Health, Unité Mixte de Recherche S953, INSERM, Paris, France ; Service de Néonatologie, Hôpital Trousseau, Assistance Publique - Hôpitaux de Paris and Université Pierre et Marie Curie, Paris, France.
authors.forename: Laurence
authors.initials: L
authors.lastname: Foix-L'Hélias
authors.affiliation: Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart, France ; U782, INSERM, Clamart, France.
authors.forename: Michael
authors.initials: M
authors.lastname: Grynberg
authors.affiliation: CESP Centre for Research in Epidemiology and Population Health, U1018, Reproduction and Child Development, INSERM, Villejuif, France ; UMRS 1018, Université Paris-Sud, Villejuif, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Ducot
authors.affiliation: Unité de Formation et de Recherche Kremlin Bicêtre, Université Paris-Sud, Le Kremlin Bicêtre, France ; Service de Biologie de la Reproduction, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart, France.
authors.forename: Nelly
authors.initials: N
authors.lastname: Frydman
authors.affiliation: Service de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart, France.
authors.forename: Violaine
authors.initials: V
authors.lastname: Kerbrat
authors.affiliation: CESP Centre for Research in Epidemiology and Population Health, U1018, Reproduction and Child Development, INSERM, Villejuif, France ; UMRS 1018, Université Paris-Sud, Villejuif, France.
authors.forename: Jean
authors.initials: J
authors.lastname: Bouyer
authors.affiliation: Unité de Formation et de Recherche Kremlin Bicêtre, Université Paris-Sud, Le Kremlin Bicêtre, France ; Service de Pédiatrie, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Labrune
mesh_terms: D001724:Birth Weight; D001827:Body Height; D001835:Body Weight; D002508:Cephalometry; D002657:Child Development; D002675:Child, Preschool; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011085:Polycystic Ovary Syndrome; D011247:Pregnancy; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic