title: The impact of APOE status on relationship of biomarkers of vascular risk and systemic inflammation to neuropsychiatric symptoms in Alzheimer's disease.
abstract: Research on the link between APOEε4 and neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) has been inconsistent. Previous work has shown a relationship between serum biomarkers of vascular risk and inflammation and NPS in AD. The current study investigated the impact of APOEε4 status on the relationship between biomarkers of cardiovascular risk, systemic inflammation, and NPS. The sample was drawn from the TARCC Longitudinal Research Cohort; the final sample of 190 consisted of 124 females and 66 males meeting the diagnostic criteria for mild to moderate AD. 115 individuals were APOEε4 carriers and 75 were non-carriers. Serum-based clinical biomarkers of vascular risk and biomarkers of inflammation related to AD were analyzed. NPS data was gathered from caretakers/family members using the Neuropsychiatric Inventory. The significant biomarkers differed for carriers and non-carriers with IL15 being a negative biomarker of total NPS accounting for 12% of the variance for carriers and IL18 and TNFα negative predictors for non-carriers (18% of variance). Patterns related to specific symptoms were similar. Stratification by gender revealed significant biomarkers of total NPS for female carriers were negative IL15 and IL1ra (18% of variance) and for female non-carriers were negative IL18 and positive homocysteine. Total cholesterol was a positive biomarker of total NPS for both male carriers (36% of variance) and non-carriers (negative TNFα and total cholesterol, 32% of variance). These findings suggest that dysregulation of inflammatory activity is related to NPS, that cholesterol is a significant factor in the occurrence of NPS, and that gender and APOE status need to be considered.
authors.affiliation: Institute of Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Hall
authors.affiliation: Institute of Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Psychiatry and Behavioral Health, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: April R
authors.initials: AR
authors.lastname: Wiechmann
authors.affiliation: Institute of Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: Leigh A
authors.initials: LA
authors.lastname: Johnson
authors.affiliation: Department of Psychology, University of North Texas, Denton, TX, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Edwards
authors.affiliation: Institute of Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Barber
authors.affiliation: Institute of Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: Rebecca
authors.initials: R
authors.lastname: Cunningham
authors.affiliation: Institute of Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: Meharvan
authors.initials: M
authors.lastname: Singh
authors.affiliation: Institute of Aging and Alzheimer's Disease Research, University of North Texas Health Science Center, Fort Worth, TX, USA Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.
authors.forename: Sid E
authors.initials: SE
authors.lastname: O'Bryant
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood / Q000150:complications / Q000235:genetics; D053327:Apolipoprotein E4 / Q000235:genetics*; D015415:Biomarkers / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology*; D008297:Male; D011569:Psychiatric Status Rating Scales; D012043:Regression, Psychology; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D053327:Apolipoprotein E4; D015415:Biomarkers; D016207:Cytokines; D014280:Triglycerides; D006710:Homocysteine; D002784:Cholesterol
keywords: APOE; Alzheimer's disease; gender; neuropsychiatric symptoms