title: [Advanced adenocarcinoma and concurrent mucosa-associated lymphoid tissue lymphoma of the stomach: a case report and literature review].
abstract: OBJECTIVE
  To investigate the clinical and pathological features of patients with concurrent gastric adenocarcinoma and primary gastric mucosa-associated lymphoid tissue (MALT) lymphoma.
  
  
  METHODS
  A 77-year-old man referred to Beijing Cancer Hospital for the evaluation of two primary cancers of stomach revealed by gastroscope was reported. The English literature was retrieved and analyzed.
  
  
  RESULTS
  Total gastrectomy was performed. Histological examination confirmed that the gastric body lesion was consistent with advanced poorly differentiated adenocarcinoma, while the lesion at the fundus with low grade MALT lymphoma. A systematic review of literature in English was performed, and 40 similar patients from 12 studies were found. There were 25 males(61.0%). More patients with adenocarcinoma were at early stage (65.9%) and the majority of lymphoma was low grade (82.9%). Furthermore, most of the patients experienced Helicobacter pylori infection (72.5%). As for therapeutic strategy, most of the patients underwent subtotal or total gastrectomy.
  
  
  CONCLUSIONS
  Concurrent gastric adenocarcinoma with MALT lymphoma is rare. The characteristics of these tumors are still unclear. The majority of gastric adenocarcinoma is at early stage, and most of the patients have Helicobacter pylori infection. The treatment is mainly based on gastric adenocarcinoma.
authors.affiliation: Department of Minimally Invasive Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China. suxiangqian@bjmu.edu.cn.
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
authors.forename: Xiangqian
authors.initials: X
authors.lastname: Su
authors.forename: Jiadi
authors.initials: J
authors.lastname: Xing
authors.forename: Ming
authors.initials: M
authors.lastname: Cui
authors.forename: Zhongwu
authors.initials: Z
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D000368:Aged; D005743:Gastrectomy; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology* / Q000601:surgery; D008297:Male; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery