title: Predictors of major postoperative complications in neonatal surgery.
abstract: OBJECTIVE
  To investigate the incidence and severity of early postoperative complications and to identify their risk factors in newborns undergoing surgery under general anesthesia.
  
  
  METHODS
  We conducted a retrospective analysis of data from 437 critically ill newborns undergoing surgery in a tertiary pediatric surgical center, between January 2000 and December 2010. Complications that occurred within the first 30 days after surgery were classified using the Clavien-Dindo system, for which grades III to V were considered severe. We used univariate and multivariate analysis to evaluate pre- and intraoperative variables potentially predictive of severe postoperative complications.
  
  
  RESULTS
  The incidence of at least one serious complication was 23%, with a median of one complication per patient 1:3. Altogether, there were 121 serious complications. Of these, 86 required surgical, endoscopic or radiological interventions (grade III), 25 endangered life, with uni or multi-organ failure (grade IV) and ten resulted in death (grade V). The most common complications were technical (25%), gastrointestinal (22%) and respiratory (21%). We identified four independent risk factors for severe postoperative complications: reoperation, operation for congenital diaphragmatic hernia, preterm birth less than 32 weeks of gestational age and abdominal surgery.
  
  
  CONCLUSIONS
  The incidence of severe postoperative complications after neonatal surgeries under general anesthesia remains high. The conditions considered independent risk factors for those can guide interventions to improve results.
authors.forename: Dora
authors.initials: D
authors.lastname: Catré
authors.forename: Maria Francelina
authors.initials: MF
authors.lastname: Lopes
authors.forename: Angel
authors.initials: A
authors.lastname: Madrigal
authors.forename: Bárbara
authors.initials: B
authors.lastname: Oliveiros
authors.forename: António Silvério
authors.initials: AS
authors.lastname: Cabrita
authors.forename: Joaquim Silva
authors.initials: JS
authors.lastname: Viana
authors.forename: José Farela
authors.initials: JF
authors.lastname: Neves
mesh_terms: D000768:Anesthesia, General; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000601:surgery*; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index