title: Lichen planopilaris after imiquimod 5% cream for multiple BCC in basal cell naevus syndrome.
abstract: Basal cell naevus syndrome is an inherited autosomal dominant genetic disorder characterised by multiple basal cell carcinomas (BCC), skeletal, neurological and opthalmological abnormalities. The treatment of choice of the often multiple and large BCC consists of a combined approach including surgery, liquid nitrogen and other topical treatment modalities. Imiquimod 5% cream is an immune-response-modifying drug with antiviral and anti-tumour activity. Recent reports have associated the immune-stimulant properties of imiquimod with the exacerbation of several autoimmune skin diseases, such as eczema, psoriasis, vitiligo and lichenoid dermatitis. Here we report a patient with basal cell naevus syndrome who developed a lichen planopilaris on the same site of the scalp, which had been previously treated with two cycles of imiquimod for multiple BCC.
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Rio de Janeiro, Brasil.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Drummond
authors.affiliation: Instituto de Dermatologia Professor Rubem David Azulay, Rio de Janeiro, Brasil.
authors.forename: Janine
authors.initials: J
authors.lastname: Pichler
authors.affiliation: Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Argenziano
authors.affiliation: Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.|Department of Dermatology, Medical University of Graz, Graz, Austria.
authors.forename: Iris
authors.initials: I
authors.lastname: Zalaudek
authors.affiliation: Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
authors.forename: Caterina
authors.initials: C
authors.lastname: Longo
authors.affiliation: Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
authors.forename: Aimilios
authors.initials: A
authors.lastname: Lallas
authors.affiliation: Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
authors.forename: Simonetta
authors.initials: S
authors.lastname: Piana
authors.affiliation: Dermatology and Skin Cancer Unit, Arcispedale S. Maria Nuova, Reggio Emilia, Italy.
authors.forename: Elvira
authors.initials: E
authors.lastname: Moscarella
mesh_terms: D000505:Alopecia / Q000139:chemically induced*; D000634:Aminoquinolines / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001478:Basal Cell Nevus Syndrome / Q000188:drug therapy*; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D000077271:Imiquimod; D008010:Lichen Planus / Q000139:chemically induced*; D008875:Middle Aged; D012535:Scalp; D063465:Skin Cream / Q000009:adverse effects; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod
keywords: Gorlin-Goltz; imiquimod 5%; lichen planopilaris