title: Impaired laryngeal voice production in a patient with foreign accent syndrome.
abstract: We report a Japanese-speaking monolingual woman who developed foreign accent syndrome (FAS) following an infarction in the precentral and premotor cortices (Brodmann Area 6) at and around the inferior frontal sulcus. Her speech sounded Chinese or Korean to our bilingual coauthor who speaks Chinese and Japanese. Quantitative acoustic analyses of words and sentences showed that pitch (fundamental frequency variation) and intensity variances appeared lowered and fully voiced glottal pulses were reduced. These findings suggest laryngeal dysfunction that contributes to the unusual speech production in a case of FAS. This may be caused by damage to a restricted area of the motor and premotor cortices that controls laryngeal function.
authors.affiliation: a Department of Neurology , Mitsui Memorial Hospital , Tokyo , Japan.
authors.forename: Yasuhisa
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Kenji
authors.initials: K
authors.lastname: Itoh
authors.forename: Keiko
authors.initials: K
authors.lastname: Sai
authors.forename: Seitetsu
authors.initials: S
authors.lastname: Lee
authors.forename: Shoko
authors.initials: S
authors.lastname: Abe
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Terao
authors.forename: Toru
authors.initials: T
authors.lastname: Mannen
mesh_terms: D000162:Acoustics; D000328:Adult; D000818:Animals; D003545:Cysteine / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D015609:Organotechnetium Compounds / Q000378:metabolism; D010700:Phonetics; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000473:pathology*; D013064:Speech Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D015899:Tomography, Emission-Computed, Single-Photon; D014831:Voice
chemical_list: D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine
keywords: apraxia of speech; glottal pulse; intensity; larynx area; pitch; precentral gyrus