title: Short follicular phase of stimulation following corifollitropin alfa or daily recombinant FSH treatment does not compromise clinical outcome: a retrospective analysis of the Engage trial.
abstract: To evaluate whether a short follicular phase of ovarian stimulation compromises the chance of pregnancy, subjects from a double-blind, randomized trial treated with a single dose of corifollitropin alfa (n=756) or daily recombinant FSH (n=750) were categorized as early responders if three follicles ≥17 mm were reached and human chorionic gonadotrophin (HCG) was administered prior to or on stimulation day 8, and as normal responders if three follicles ≥17 mm were reached and HCG was administered after stimulation day 8. In the corifollitropin alfa and recombinant FSH groups, 23.2% and 29.1%, respectively, were early responders (P=0.01). Regardless of the treatment group, the initial ovarian response was higher in early responders, but with two extra days of stimulation, the number and size of follicles on the day of HCG in the normal responders was similar to those of the early responders. The number of oocytes was similar in both response groups following corifollitropin alfa treatment (13.6 versus 14.5) and recombinant FSH treatment (12.8, both groups). The ongoing pregnancy rates were comparable for early and normal responders regardless of the treatment group, supporting successful outcome following a stimulation period of only 1 week.
authors.affiliation: Institut Pronatal, Prague, Czech Republic. Electronic address: Tonko.Mardesic@seznam.cz.
authors.forename: Tonko
authors.initials: T
authors.lastname: Mardešič
authors.affiliation: MSD, The Netherlands.
authors.forename: Bernadette
authors.initials: B
authors.lastname: Mannaerts
authors.affiliation: Center for Reproductive Medicine, Hurley Medical Center, Flint, MI, USA.
authors.forename: Mostafa
authors.initials: M
authors.lastname: Abuzeid
authors.affiliation: Shady Grove Fertility, Rockville, MD, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Levy
authors.affiliation: MSD, The Netherlands.
authors.forename: Han
authors.initials: H
authors.lastname: Witjes
authors.affiliation: Department of Reproductive Medicine and Gynecology, University Medical Center, Utrecht, The Netherlands.
authors.forename: Bart C J M
authors.initials: BC
authors.lastname: Fauser
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004311:Double-Blind Method; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D043373:Follicle Stimulating Hormone, Human / Q000008:administration & dosage*; D005498:Follicular Phase / Q000502:physiology; D006801:Humans; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D006063:Chorionic Gonadotropin; D043373:Follicle Stimulating Hormone, Human; D011994:Recombinant Proteins; C437186:follicle stimulating hormone, human, with HCG C-terminal peptide; D005640:Follicle Stimulating Hormone
keywords: corifollitropin alfa; infertility; ongoing pregnancy rate; ovarian stimulation; recombinant FSH; short follicular phase