title: [Therapy monitoring of neoadjuvant therapy with MRI. RECIST and functional imaging].
abstract: OBJECTIVE
  Neoadjuvant chemotherapy is increasingly being applied in patients with operable breast cancer. Thus, an early prediction of response to neoadjuvant chemotherapy is of high relevance.
  
  
  METHODS
  The interobserver variability of clinical examination, mammography and ultrasonography in the assessment of response to neoadjuvant chemotherapy is high.
  
  
  METHODS
  Magnetic resonance imaging (MRI) allows the assessment of functional parameters in addition to changes in tumor size and morphology.
  
  
  METHODS
  A reliable therapy response monitoring aims at optimizing individualized patient care.
  
  
  RESULTS
  This paper summarizes current guidelines for the assessment of response to neoadjuvant chemotherapy in breast cancer according to the response evaluation criteria in solid tumors (RECIST). Furthermore, the technical principles of MRI-based therapy monitoring are described and an overview of the clinical studies that have assessed the feasibility of functional MRI in response to treatment evaluation is given.
  
  
  CONCLUSIONS
  The technology of functional MRI offers promising results concerning therapy response monitoring. However, the level of evidence is not sufficiently evaluated for the technologies of functional MRI presented here.
authors.affiliation: Institut für Klinische Radiologie, Klinikum der Ludwig-Maximilians-Universität, Campus Großhadern, Marchioninistr. 15, 81377, München, Deutschland, susanne.grandl@med.uni-muenchen.de.
authors.forename: S
authors.initials: S
authors.lastname: Grandl
authors.forename: M
authors.initials: M
authors.lastname: Ingrisch
authors.forename: K
authors.initials: K
authors.lastname: Hellerhoff
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant / Q000592:standards; D005260:Female; D006801:Humans; D038622:Internationality; D008279:Magnetic Resonance Imaging / Q000592:standards*; D008495:Medical Oncology / Q000592:standards*; D020360:Neoadjuvant Therapy / Q000592:standards; D017063:Outcome Assessment, Health Care / Q000592:standards*; D017410:Practice Guidelines as Topic; D011871:Radiology / Q000592:standards*; D016896:Treatment Outcome