title: Association between rs11614913 polymorphism in miR-196a2 and colorectal cancer risk: a meta-analysis.
abstract: BACKGROUND
  MicroRNAs (miRNAs) are small non-coding RNAs of 20-22 nucleotides in length, which regulate the translation or degradation of human messenger RNA (mRNA). MiRNAs involve in the regulation of most biological processes, as well as human diverse diseases including cancer. Recently, many studies investigated the association between miR-196a2 rs11614913 polymorphism and colorectal cancer (CRC), which showed inconclusive results.
  
  
  RESULTS
  We conducted a meta-analysis of 6 studies that included 1800 cases and 2329 controls. There was a statistically decreased risk of CRC in dominant model, recessive model and homozygous model. In the Asian group, significantly decreased susceptibility of CRC was found in allele model, dominant model, recessive model and homozygous model. As for the Caucasian group, none of genetic models demonstrates significant association between miR-196a2 rs11614913 polymorphism and susceptibility of CRC.
  
  
  CONCLUSIONS
  These findings supported that miR-196a2 rs11614913 polymorphism may contribute to the susceptibility of CRC.
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Du
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors.forename: Xuelei
authors.initials: X
authors.lastname: Ma
authors.affiliation: West China School of Medicine, Sichuan University, Sichuan, China.
authors.forename: Weiqi
authors.initials: W
authors.lastname: Kong
authors.affiliation: The Second Affiliated Hospital of Xuzhou Medical College China, Xuzhou, Jinagsu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liu
authors.affiliation: Yaan People Hospital, Sichuan, China.
authors.forename: Benling
authors.initials: B
authors.lastname: Wei
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors.forename: Jiayun
authors.initials: J
authors.lastname: Yu
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Li
authors.affiliation: West China Hospital, Sichuan University, Sichuan, China.
authors.forename: Jingwen
authors.initials: J
authors.lastname: Huang
authors.affiliation: The Second Affiliated Hospital of Xuzhou Medical College China, Xuzhou, Jinagsu, China.
authors.forename: Zikang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: C542543:MIRN196 microRNA, human; D035683:MicroRNAs
keywords: Colorectal cancer; miR-196a2; polymorphism