title: Enhancing dissolution of domperidone by spray-drying: effect of different storage conditions on stability.
abstract: BACKGROUND
  Domperidone is an antidopaminergic drug that facilitates a function of the digestive smooth muscle. Depending on the Biopharmaceutical Classification System, domperidone is classified as class II with poor solubility and high permeability.
  
  
  RESULTS
  Solid dispersions were prepared by spray-drying with a polymer. The characterization of prepared solid dispersions was analyzed by scanning electron microscope, Fourier transform infrared spectroscopy, x-ray diffraction and differential scanning calorimeter. In vitro dissolution behavior was carried out in gastric juice (pH 1.2) and these results were compared with pure domperidone (active pharmaceutical ingredient). The dissolution rate was improved due to the influence of polymers. Stability assays were conducted by the same pre-experiment. Storage conditions of the solid dispersions were as follows: 25°C relative humidity 25% and 65°C relative humidity 80%.
  
  
  CONCLUSIONS
  In this study, the goal is to improve the dissolution rate of domperidone by solid dispersions and to confirm stability of the prepared solid dispersions. It suggests that the content of polymers added in solid dispersions can affect the dissolution behavior and change dissolution rate of drug.
authors.affiliation: Department of BIN Fusion Technology, Department of Polymer Nano Science & Technology & Polymer BIN Research Center, Chonbuk National University, 567 Baekje-daero, Deokjin, Jeonju 561-756, Korea.
authors.forename: Jung H
authors.initials: JH
authors.lastname: Lee
authors.forename: Min J
authors.initials: MJ
authors.lastname: Kim
authors.forename: Jaewon
authors.initials: J
authors.lastname: Yang
authors.forename: Kyoung H
authors.initials: KH
authors.lastname: Kim
authors.forename: Hye M
authors.initials: HM
authors.lastname: Kim
authors.forename: So J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Dongwon
authors.initials: D
authors.lastname: Lee
authors.forename: Gilson
authors.initials: G
authors.lastname: Khang
mesh_terms: D000336:Aerosols; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D003890:Desiccation; D004294:Domperidone / Q000737:chemistry*; D018492:Dopamine Antagonists / Q000737:chemistry*; D004337:Drug Carriers; D004355:Drug Stability; D004356:Drug Storage; D005750:Gastric Juice / Q000737:chemistry; D006813:Humidity; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods; D013696:Temperature
chemical_list: D000336:Aerosols; D018492:Dopamine Antagonists; D004337:Drug Carriers; D004294:Domperidone; D011205:Povidone