title: Multiscale computational analysis of the bioelectric consequences of myocardial ischaemia and infarction.
abstract: Ischaemic heart disease is considered as the single most frequent cause of death, provoking more than 7 000 000 deaths every year worldwide. A high percentage of patients experience sudden cardiac death, caused in most cases by tachyarrhythmic mechanisms associated to myocardial ischaemia and infarction. These diseases are difficult to study using solely experimental means due to their complex dynamics and unstable nature. In the past decades, integrative computational simulation techniques have become a powerful tool to complement experimental and clinical research when trying to elucidate the intimate mechanisms of ischaemic electrophysiological processes and to aid the clinician in the improvement and optimization of therapeutic procedures. The purpose of this paper is to briefly review some of the multiscale computational models of myocardial ischaemia and infarction developed in the past 20 years, ranging from the cellular level to whole-heart simulations.
authors.affiliation: Departamento de Ingeniería Electrónica, Instituto I3BH, Universitat Politècnica de València, Camino de Vera s/n, 46022 Valencia, Spain.
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ferrero
authors.forename: Beatriz
authors.initials: B
authors.lastname: Trenor
authors.forename: Lucia
authors.initials: L
authors.lastname: Romero
mesh_terms: D000200:Action Potentials; D000818:Animals; D003198:Computer Simulation; D006329:Heart Conduction System / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000503:physiopathology*; D032383:Myocytes, Cardiac
keywords: Computer simulations; Infarction; Ischaemia; Mathematical models; Reentrant arrhythmias