title: Serum uric acid levels are associated with high blood pressure in Chinese children and adolescents aged 10-15 years.
abstract: OBJECTIVE
  The present study examined the association between uric acid levels and high blood pressure in a multiethnic study of Chinese children and adolescents.
  
  
  METHODS
  The participants were divided into four different groups according to the uric acid quartiles. Three logistic regression models were conducted to investigate the relationship between the high blood pressure and uric acid levels. Model 1 adjusted age, sex and ethnicity. Model 2 adjusted age, sex, ethnicity, total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, estimated glomerular filtration rate, fasting glucose and waist circumference. Model 3 adjusted all the confounding factors in model 2 except the waist circumference and BMI. The concentrations of uric acid in high blood pressure participants and normotensive participants were compared with or without adjustment for confounding factors.
  
  
  RESULTS
  A total of 3778 participants aged 10-15 years from the Xinjiang Congenital Heart Disease Survey were included in the present study. The percentages of the high blood pressure in the four different uric acid quartiles were 7.4, 8.6, 9.6 and 11.8%, respectively. In model 1, 2 and 3 of the logistic regression, the participants in the third and fourth uric acid quartiles had significantly higher chance of suffering the high blood pressure when compared with the participants in the first uric acid quartile [odds ratio 1.608, 1.587, 1.597, P = 0.005, 0.015, 0.015, respectively, between participants in the first quartile and the third quartile; odds ratio 1.981, 1.945, 1.810, P = 0.001, 0.002, 0.007, respectively, between participants in the first quartile and the fourth quartile). The concentrations of serum uric acid were 220.7 μmol/l in high blood pressure participants and 204.1 μmol/l in normotensive participants (P = 0.024). After adjustment for confounding factors, the concentrations of serum uric acid were 219.7 vs. 204.5 μmol/l in one model (P < 0.001) and 219.3 vs. 204.5 μmol/l in the other model (P < 0.001).
  
  
  CONCLUSIONS
  Among Chinese children and adolescents, increasing levels of serum uric acid are associated with high blood pressure.
authors.affiliation: aDepartment of Cardiology, First Affiliated Hospital of Xinjiang Medical University bXinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, People's Republic of China cDivision of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan *Shuo Pan and Chun-Hui He contribute equally to the writing of the article.
authors.forename: Shuo
authors.initials: S
authors.lastname: Pan
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: He
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.forename: Zhen-Yan
authors.initials: ZY
authors.lastname: Fu
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Zi-Xiang
authors.initials: ZX
authors.lastname: Yu
authors.forename: You
authors.initials: Y
authors.lastname: Chen
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000293:Adolescent; D002648:Child; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid