title: Erosion protection comparison of stabilised SnF2 , mixed fluoride active and SMFP/arginine-containing dentifrices.
abstract: OBJECTIVE
  To investigate the relative erosion protection potential of marketed dentifrices formulated with either stabilised stannous fluoride (SnF2 ), sodium fluoride (NaF) and/or sodium monofluorophosphate (SMFP) using an established laboratory erosion cycling model.
  
  
  METHODS
  Sound enamel cores from extracted, human enamel were cleaned, ground and polished, soaked in pooled saliva (pellicle formation) and treated with a 1:3 slurry of dentifrice and saliva. Specimens were subjected to daily challenges with 1% citric acid, a potentially damaging acid found in common food and drinks. Marketed dentifrices compared were: (1) a stabilised stannous fluoride product formulated with 1,100 ppm F as SnF2 ; (2) a cavity protection product containing 1,100 ppm F as NaF; (3) a cavity protection product comprising a mixed active fluoride system with 1,000 ppm F as SMFP + 450 ppm F as NaF; and (4) a sensitivity product containing 1,450 ppm F as SMFP + 8% arginine bicarbonate.
  
  
  RESULTS
  Specimens from Group 1 demonstrated an average loss of 5.5 (±1.2) μm of tooth surface enamel; Groups 2, 3 and 4 lost an average of 18.3 (±0.9) μm, 16.0 (±2.0) μm and 17.1 (±1.1) μm, respectively, of tooth surface enamel. Group 1 provided a statistically significant difference in protection compared with the other products.
  
  
  CONCLUSIONS
  These results suggest that the marketed dentifrice formulated with stabilised SnF2 may provide enhanced protection of exposed tooth surfaces against dietary acid attack compared with the other products tested.
authors.affiliation: The Procter & Gamble Company, Mason, OH, USA.
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Eversole
authors.forename: Kymberly
authors.initials: K
authors.lastname: Saunders-Burkhardt
authors.forename: Robert V
authors.initials: RV
authors.lastname: Faller
mesh_terms: D001120:Arginine / Q000627:therapeutic use*; D019343:Citric Acid / Q000009:adverse effects; D045424:Complex Mixtures / Q000627:therapeutic use; D003743:Dental Enamel / Q000187:drug effects / Q000648:ultrastructure; D044622:Dental Pellicle / Q000502:physiology; D003802:Dentifrices / Q000627:therapeutic use*; D005459:Fluorides / Q000627:therapeutic use*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008852:Microradiography / Q000379:methods; D010710:Phosphates / Q000627:therapeutic use*; D017680:Potassium Compounds / Q000627:therapeutic use; D020011:Protective Agents / Q000627:therapeutic use; D012463:Saliva / Q000502:physiology; D012824:Silicic Acid / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use*; D014002:Tin Fluorides / Q000627:therapeutic use*; D014077:Tooth Erosion / Q000473:pathology / Q000517:prevention & control*; D014100:Toothpastes / Q000627:therapeutic use
chemical_list: D045424:Complex Mixtures; C510825:Crest Pro-Health Dentifrice; D003802:Dentifrices; D010710:Phosphates; D017680:Potassium Compounds; D020011:Protective Agents; D014002:Tin Fluorides; D014100:Toothpastes; C444700:colgate sensitive; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; C012980:fluorophosphate; D019343:Citric Acid; D012969:Sodium Fluoride; D001120:Arginine; D005459:Fluorides
keywords: Erosion; arginine bicarbonate; dentifrice; fluoride; mixed fluoride; stannous fluoride