title: [Association of leptin receptor gene polymorphisms with hypertension in Chinese population: a meta-analysis].
abstract: OBJECTIVE
  To evaluate the association between leptin receptor gene polymorphisms and hypertension in Chinese population.
  
  
  METHODS
  The keywords "Hypertension", "Blood Pressure, high", "Leptin Receptor", "OB Receptor", "LEPR Protein", "CD295 Antigens", and "LEPR" were used to search the literature to identify the relevant studies for meta-analysis using software RevMan 5.0 and Stata 11.0 software.
  
  
  RESULTS
  Thirteen studies involving 3210 cases of hypertension and 1881 controls were included in the meta-analysis. Overall, a significant association was found between Gln223Arg gene polymorphism and hypertension in allele contrast and dominant genetic model (for allele contrast genetic model: OR=1.17, 95%CI=1.48-2.15, P<0.0001; for dominant model: OR=2.18, 95%CI=1.75-2.72, P<0.00001). No statistically significant correlation was found between Lys109Arg polymorphism and hypertension (for allele model: OR=1.13, 95%CI=0.84-1.51, P=0.42; for recessive genetic model: OR=0.88, 95%CI=0.33-2.32, P=0.79; for dominant genetic model: OR=1.20, 95%CI=0.85-1.71, P=0.29; for additive genetic model: OR=0.90, 95%CI=0.34-2.42, P=0.84).
  
  
  CONCLUSIONS
  There is no significant correlation between Lys109Arg variant of LEPR gene and hypertension in Chinese population, but the Gln223Arg polymorphism is associated with hypertension in allele contrast and dominant genetic model. Chinese population with an A allele are at a high risk of developing hypertension.
authors.affiliation: Department of Epidemiology, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China.E-mail: 1029jin@163.com.
authors.forename: Nan
authors.initials: N
authors.lastname: Jin
authors.forename: Hui
authors.initials: H
authors.lastname: Sli
authors.forename: Fan
authors.initials: F
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Bing
authors.initials: B
authors.lastname: Leng
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D054411:Receptors, Leptin / Q000235:genetics*
chemical_list: D054411:Receptors, Leptin