title: Versatile chiral chromatography with mixed stationary phases of water-impregnated silica gel and reversed-phase packing.
abstract: A novel chiral chromatographic scheme is proposed, which requires no organic syntheses in stationary phase preparation. A normal phase chiral chromatography stationary phase is prepared by simple passage of an aqueous solution of an appropriate chiral selector through e.g. a silica gel column. For this scheme, a mixed-bed of bare silica gel and octadecylsilanized silica gel (ODS) provides much better separation performance than a silica gel column. Isolation of silica gel particles in the column is important for successful chiral separation based on the present scheme.
authors.affiliation: Department of Chemistry, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8551, Japan. tokada@chem.titech.ac.jp.
authors.forename: Satsuki
authors.initials: S
authors.lastname: Takahashi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Okada
mesh_terms: D056148:Chromatography, Reverse-Phase / Q000295:instrumentation*; D058428:Silica Gel
chemical_list: D058428:Silica Gel