title: A pilot study of depot medroxyprogesterone acetate pharmacokinetics and weight gain in adolescent females.
abstract: OBJECTIVE
  To explore the relationship between medroxyprogesterone acetate (MPA) pharmacokinetic (PK) parameter estimates and weight gain.
  
  
  METHODS
  Prospective study of adolescents (N=40; age 12-21 years) initiating DMPA. PK parameters were calculated: maximum MPA concentration (Cmax, ng/mL), time to Cmax (Tmax, days) and elimination rate constant (ng/mL/day). Optimal PK cut points were determined for predicting body mass index (BMI) increase ≥10%.
  
  
  RESULTS
  Cmax <2.88 ng/mL and elimination rate constant <0.021 ng/mL/day were associated (p<.05) with BMI increase ≥10%. Elimination rate constant was most predictive of weight gain.
  
  
  CONCLUSIONS
  PK evaluation may help identify adolescents at risk of excessive DMPA-associated weight gain.
authors.affiliation: Nationwide Children's Hospital, Columbus, OH, USA; The Ohio State University, Columbus, OH, USA; The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Electronic address: andrea.bonny@nationwidechildrens.org.
authors.forename: Andrea E
authors.initials: AE
authors.lastname: Bonny
authors.affiliation: The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Hannah L H
authors.initials: HL
authors.lastname: Lange
authors.affiliation: The Ohio State University, Columbus, OH, USA; The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
authors.forename: Lynette K
authors.initials: LK
authors.lastname: Rogers
authors.affiliation: Biostats Inc., East Canton, OH, USA.
authors.forename: Dave M
authors.initials: DM
authors.lastname: Gothard
authors.affiliation: Akron Children's Hospital and the Rebecca D. Considine Research Institute, Akron, OH, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Reed
mesh_terms: D000293:Adolescent; D002648:Child; D003271:Contraceptive Agents, Female / Q000009:adverse effects* / Q000493:pharmacokinetics; D005260:Female; D064368:Healthy Volunteers; D006801:Humans; D017258:Medroxyprogesterone Acetate / Q000009:adverse effects* / Q000493:pharmacokinetics; D010865:Pilot Projects; D011446:Prospective Studies; D015430:Weight Gain / Q000187:drug effects*; D055815:Young Adult
chemical_list: D003271:Contraceptive Agents, Female; D017258:Medroxyprogesterone Acetate
keywords: Adolescence; Contraception; Depo Provera; Pharmacokinetics; Weight