title: Fatty liver and serum cholinesterase are independently correlated with HbA1c levels: cross-sectional analysis of 5384 people.
abstract: OBJECTIVE
  To examine the association between glycosylated haemoglobin (HbA1c) and fatty liver markers.
  
  
  METHODS
  This cross-sectional analysis stratified subjects into quintiles based on HbA1c. Fatty liver using ultrasonography scores (FLUS) were assigned as follows: 2 points, moderate or severe fatty liver; 1 point, mild fatty liver; and 0 points, normal liver. Subjects with viral hepatitis, alcohol intake >175 g/week or receiving hypoglycaemic treatment were excluded.
  
  
  RESULTS
  The study included 5384 subjects. Serum cholinesterase (ChE) and FLUS showed a significant graded increase with increasing HbA1c. In linear regression analysis stratified by body mass index (BMI) and age, ChE and FLUS were significantly associated with lower (1 + 2) and higher (3 + 4 + 5) HbA1c quintiles, respectively, independent of BMI and age.
  
  
  CONCLUSIONS
  The findings show that both ChE and FLUS are significantly correlated with HbA1c, independent of BMI and age.
authors.affiliation: Jikei University Harumi Triton Clinic, Jikei University School of Medicine, Tokyo, Japan.
authors.forename: Shuichi
authors.initials: S
authors.lastname: Katoh
authors.forename: Markku
authors.initials: M
authors.lastname: Peltonen
authors.forename: Takashi
authors.initials: T
authors.lastname: Wada
authors.forename: Mikio
authors.initials: M
authors.lastname: Zeniya
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Kazunori
authors.initials: K
authors.lastname: Utsunomiya
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D015992:Body Mass Index; D002802:Cholinesterases / Q000097:blood*; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000097:blood* / Q000000981:diagnostic imaging*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002802:Cholinesterases; D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human
keywords: Cholinesterase; HbA1c; non-alcoholic fatty liver disease