title: A rare case of undifferentiated nonkeratinizing carcinoma of the lip mucosa.
abstract: Undifferentiated nonkeratinizing carcinoma (UNC) is a poorly differentiated squamous cell carcinoma accompanied by a prominent reactive lymphoplasmacytic infiltrate that can occur in many anatomic sites. It shares morphologic features with undifferentiated nonkeratinizing nasopharyngeal carcinoma, in which a strong association with Epstein-Barr virus (EBV) has been noted. Among UNCs arising outside the nasopharynx, the linkage with EBV is variable; in particular, the few cases of UNC of the lip described thus far have been negative for EBV. This report describes a rare case of primary UNC of the lower lip mucosa in a 73-year-old man in whom molecular analysis for EBV showed some amount of viral DNA within the tumor. Surgical excision without adjuvant treatment was performed and the patient was alive without recurrence after 42 months of follow-up. This report presents a rare localization of UNC possibly related to EBV infection and with a good clinical outcome.
authors.affiliation: Medical Doctor, Department of Medical and Biological Sciences, Institution of Anatomic Pathology, Azienda Ospedaliero Universitaria S Maria della Misericordia, Udine, Italy. Electronic address: enrico.pegolo.81@gmail.com.
authors.forename: Enrico
authors.initials: E
authors.lastname: Pegolo
authors.affiliation: Associate Professor of Plastic and Reconstructive Surgery, Department of Experimental and Clinical Medical Sciences, Institution of Plastic and Reconstructive Surgery, Azienda Ospedaliero Universitaria S Maria della Misericordia, Udine, Italy.
authors.forename: Piercamillo
authors.initials: P
authors.lastname: Parodi
authors.affiliation: Medical Doctor, Department of Experimental and Clinical Medical Sciences, Institution of Plastic and Reconstructive Surgery, Azienda Ospedaliero Universitaria S Maria della Misericordia, Udine, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Francescon
authors.affiliation: Full Professor of Anatomic Pathology, Department of Medical and Biological Sciences, Institution of Anatomic Pathology, Azienda Ospedaliero Universitaria S Maria della Misericordia, Udine, Italy.
authors.forename: Carla
authors.initials: C
authors.lastname: Di Loreto
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008048:Lip Neoplasms / Q000821:virology*; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D010950:Plasma Cells / Q000473:pathology; D021701:Sentinel Lymph Node Biopsy; D013524:Surgical Flaps / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D004279:DNA, Viral; D019309:Epstein-Barr Virus Nuclear Antigens; C417029:EBV-encoded nuclear antigen 1