title: The Skin-Resident Immune Network.
abstract: The skin provides an effective physical and biological barrier against environmental and pathogenic insults whilst ensuring tolerance against commensal microbes. This protection is afforded by the unique anatomy and cellular composition of the skin, particularly the vast network of skin-associated immune cells. These include the long-appreciated tissue-resident macrophages, dendritic cells, and mast cells, as well as the more recently described dermal γδ T cells and innate lymphoid cells. Collectively, these cells orchestrate the defense against a wide range of pathogens and environmental challenges, but also perform a number of homeostatic functions. Here, we review recent developments in our understanding of the various roles that leukocyte subsets play in cutaneous immunobiology, and introduce the newer members of the skin immune system. Implications for human disease are discussed.
authors.affiliation: Centenary Institute, Locked Bag 6, Newtown, NSW 2042 Australia.
authors.forename: Szun S
authors.initials: SS
authors.lastname: Tay
authors.affiliation: Centenary Institute, Locked Bag 6, Newtown, NSW 2042 Australia.
authors.forename: Ben
authors.initials: B
authors.lastname: Roediger
authors.affiliation: Centenary Institute, Locked Bag 6, Newtown, NSW 2042 Australia ; Discipline of Dermatology, University of Sydney, Sydney, 2006 NSW Australia ; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, 2050 NSW Australia.
authors.forename: Philip L
authors.initials: PL
authors.lastname: Tong
authors.affiliation: Centenary Institute, Locked Bag 6, Newtown, NSW 2042 Australia.
authors.forename: Shweta
authors.initials: S
authors.lastname: Tikoo
authors.affiliation: Centenary Institute, Locked Bag 6, Newtown, NSW 2042 Australia ; Discipline of Dermatology, University of Sydney, Sydney, 2006 NSW Australia ; Department of Dermatology, Royal Prince Alfred Hospital, Camperdown, 2050 NSW Australia.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weninger
keywords: Dendritic cells; Innate immune system; Innate lymphoid cells; Langerhans cells; Macrophages; Mast cells; γδ T cells