title: To phosphorylate or not to phosphorylate: Selective alterations in tyrosine kinase-inhibited EphB mutant mice.
abstract: EphB tyrosine kinase receptors have been implicated in multiple developmental processes; however, the signaling mechanism underlying these events remains unclear. Through a triple knock-in mouse line for three neurally expressed EphBs, Sokis et al. demonstrated that EphB tyrosine kinase activity is required for axon guidance but does not influence synapse formation. This short communication highlights their study and appealing molecular approach that elucidated the functions of EphB tyrosine kinase during developmental events.
authors.affiliation: Joint master in Neuroscience; University of Strasbourg-France; Strasbourg, France.
authors.forename: Dhanasak
authors.initials: D
authors.lastname: Dhanasobhon
authors.affiliation: Joint master in Neuroscience; University of Strasbourg-France; Strasbourg, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Savier
authors.affiliation: Joint master in Neuroscience; University of Strasbourg-France; Strasbourg, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Lelievre
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology* / Q000502:physiology*; D001923:Brain Chemistry / Q000235:genetics*; D005260:Female; D006801:Humans; D011247:Pregnancy; D015202:Protein Engineering / Q000379:methods*; D036081:Receptors, Eph Family / Q000235:genetics*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D036081:Receptors, Eph Family
keywords: Eph B; PP1 analogue; bidirectional signaling; ephrin; tyrosine kinase