title: Antibacterial, kinetics and bacteriolytic properties of silver(I) pyridinedicarboxylate compounds.
abstract: Antibacterial properties of silver(I)-pyridinedicarboxylate compounds (with Pyridine-2,3-dicarboxylic(Lutidinic acid), pyridine-2,4-dicarboxylic (Quinolinic acid) and pyridine-2,5-dicarboxylic (Isocinchomeronic acid)) were studied against Escherichia coli, Listeria monocytogenes (ISP-65-08), Salmonella typhi and Staphylococcus aureus (ATCC 25923) using kinetics of grown inhibition, viability assays, minimum inhibitory concentration and optical microscopy. The 3 silver compounds were tested toward UV-radiation in order to characterize their light insensitivity for potential medical devices: UV-radiation curable polymers. Photophysical measurements show remarkable differences toward UV-radiation, which were explained based on their polymeric structures with multiple nature bonds between pyridinedicarboxylic ligands and Ag(I) centers. We found a bacteriolytic effect and differences in the antibacterial efficiency depending on the structure of the complexes and the nature of AgX (X=oxygen and nitrogen) bonds: AgQuinol>AgLutidin>AgIsocinchom.
authors.affiliation: Facultad de Química y Biología, Universidad de Santiago de Chile, Av. Bernardo O'Higgins 3363, Santiago, Chile. Electronic address: manuel.azocar@usach.cl.
authors.forename: M Ignacio
authors.initials: MI
authors.lastname: Azócar
authors.affiliation: Facultad de Química y Biología, Universidad de Santiago de Chile, Av. Bernardo O'Higgins 3363, Santiago, Chile.
authors.forename: Grace
authors.initials: G
authors.lastname: Gómez
authors.affiliation: Facultad de Química y Biología, Universidad de Santiago de Chile, Av. Bernardo O'Higgins 3363, Santiago, Chile.
authors.forename: Carla
authors.initials: C
authors.lastname: Velásquez
authors.affiliation: Facultad de Química y Biología, Universidad de Santiago de Chile, Av. Bernardo O'Higgins 3363, Santiago, Chile.
authors.forename: Romina
authors.initials: R
authors.lastname: Abarca
authors.affiliation: Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile. Advanced Center for Chronic Diseases (ACCDiS).
authors.forename: Marcelo J
authors.initials: MJ
authors.lastname: Kogan
authors.affiliation: Facultad de Química y Biología, Universidad de Santiago de Chile, Av. Bernardo O'Higgins 3363, Santiago, Chile.
authors.forename: Maritza
authors.initials: M
authors.lastname: Páez
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D007700:Kinetics; D008089:Listeria monocytogenes / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011108:Polymers / Q000737:chemistry / Q000528:radiation effects; D011725:Pyridines / Q000737:chemistry; D012485:Salmonella typhi / Q000187:drug effects; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D014466:Ultraviolet Rays
chemical_list: D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D056831:Coordination Complexes; D011108:Polymers; D011725:Pyridines; D012834:Silver; C023666:pyridine
keywords: Antibacterial; Insensitivity UV light; Medical devices; Silver(I)