title: Childhood sleep duration and quality in relation to leptin concentration in two cohort studies.
abstract: OBJECTIVE
  Poor sleep in childhood is associated with increased obesity risk, possibly by affecting appetite-regulating hormones such as leptin. We examined short- and long-term sleep duration and quality in relation to leptin in two US pediatric cohorts.
  
  
  METHODS
  Analysis of data from two prospective cohort studies.
  
  
  METHODS
  Population-based. Adolescent polysomnography assessments performed in a clinical research unit.
  
  
  METHODS
  Children in Project Viva (n = 655) and adolescents in the Cleveland Children's Sleep & Health Study (n = 502).
  
  
  METHODS
  N/A.
  
  
  RESULTS
  In Project Viva, mothers reported average child sleep duration annually from infancy through age 7, and we measured leptin at ages 3 and 7. In the Cleveland Children's Sleep & Health Study, we collected self-reported sleep duration, polysomnography-derived measures of sleep quality, and fasting leptin at ages 16-19. In sex-stratified linear regression analyses adjusted for sociodemographic characteristics and adiposity, chronic curtailed sleep was associated with lower leptin at age 7 in girls; a one-unit decrease in sleep score was associated with a 0.08 decrease in log leptin (95% CI: 0.01,0.15). The association was stronger in girls with greater adiposity (P = 0.01). Among adolescents, shorter sleep was associated with lower leptin in males; each one-hour decrease in sleep duration was associated with a 0.06 decrease in log leptin (95% CI: 0.00, 0.11). Sleep duration was not associated with leptin at other ages. Sleep quality indices were not associated with leptin.
  
  
  CONCLUSIONS
  Our results suggest possible age-specific sexual dimorphism in the influence of sleep on leptin, which may partly explain inconsistencies in the literature.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, MA ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
authors.forename: Caroline E
authors.initials: CE
authors.lastname: Boeke
authors.affiliation: Statistical Research Consultants, LLC, Schaumburg, IL.
authors.forename: Amy
authors.initials: A
authors.lastname: Storfer-Isser
authors.affiliation: Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA ; Division of Pulmonary Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA ; Harvard Medical School, Boston, MA ; Department of Medicine, Brigham and Women's Hospital, Boston, MA.
authors.forename: Susan
authors.initials: S
authors.lastname: Redline
authors.affiliation: Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA ; Departments of Pediatrics and Population Medicine, Harvard Medical School, Boston, MA.
authors.forename: Elsie M
authors.initials: EM
authors.lastname: Taveras
mesh_terms: D050154:Adiposity / Q000502:physiology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D020738:Leptin / Q000097:blood*; D008297:Male; D009035:Mothers; D009765:Obesity / Q000097:blood / Q000503:physiopathology; D009820:Ohio; D017286:Polysomnography; D011446:Prospective Studies; D057566:Self Report; D012727:Sex Characteristics; D012890:Sleep / Q000502:physiology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D020738:Leptin
keywords: Sleep; leptin; obesity; youth