title: Stereotactic body radiation therapy as a bridge to transplantation and for recurrent disease in the transplanted liver of a patient with hepatocellular carcinoma.
abstract: Hepatocellular carcinoma (HCC) is one of the most common causes of cancer mortality worldwide. Despite orthotopic liver transplantation (OLT), recurrent HCC is a major cause of morbidity. In this case report, we evaluate the efficacy of stereotactic body radiation therapy (SBRT) as a bridge to OLT and for recurrence in the transplanted liver of a patient with HCC. A 52-year-old male with a history of chronic hepatitis C presented with a 1.7-cm liver lesion radiographically consistent with HCC, which was subsequently treated with a course of SBRT to 50 Gy in 5 fractions followed by OLT in 2009. The patient had a 2.2-cm recurrence in the transplanted liver in 2012, which was treated with SBRT to 62.5 Gy in 5 fractions. He tolerated the course of radiotherapy well with no significant radiation-related toxicity and remains in complete remission approximately 1 year after SBRT. SBRT is a safe and effective modality for the treatment of recurrent HCC in the transplanted liver of the same patient initially treated with SBRT as a bridge to OLT.
authors.affiliation: Department of Radiation Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, N.Y., USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Mazloom
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, N.Y., USA.
authors.forename: Aram F
authors.initials: AF
authors.lastname: Hezel
authors.affiliation: Department of Radiation Oncology, Department of Medicine, University of Rochester Medical Center, Rochester, N.Y., USA.
authors.forename: Alan W
authors.initials: AW
authors.lastname: Katz
keywords: Hepatocellular carcinoma; Orthotopic liver transplantation; Stereotactic body radiation therapy