title: Effects of drospirenone pill in Indian women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To study the effects of treatment with a drospirenone pill (DRSP) (with ethinyl oestradiol, EE) in Indian women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Fifty-one women with PCOS (Androgen excess society criteria, 2006), with preset inclusion-exclusion criteria, treated with a combination of EE 30 mcg and DRSP 3 mg cyclically in the traditional (21+7) regimen, were evaluated at baseline and after six and twelve cycles of treatment. Parameters studied were - body mass index (BMI), abdominal circumference (AC), Ferriman Galwey (FG) score, presence of acne and acanthosis nigricans, serum testosterone, sex hormone binding globulin (SHBG), fasting glucose and fasting insulin levels. Free Androgen Index (FAI) and Glucose: Insulin ratio (G: I) were calculated.
  
  
  RESULTS
  Significant improvements in clinical and biochemical hyperandrogenic parameters were found at the two points of study. There were no significant changes in BMI, AC, incidence of acanthosis, or metabolic parameters studied.
  
  
  CONCLUSIONS
  EE/DRSP improves hyperandrogenic parameters significantly without affecting the insulin resistance adversely in Indian women with PCOS.
authors.affiliation: Department of Obstetrics and Gynaecology, KPC Medical College, Kolkata, India.
authors.forename: Sudhindra Mohan
authors.initials: SM
authors.lastname: Bhattacharya
authors.affiliation: Department of Pharmacology, Calcutta Medical College, Kolkata, India.
authors.forename: Mainak
authors.initials: M
authors.lastname: Ghosh
authors.affiliation: Department of Obstetrics and Gynaecology, KPC Medical College, Kolkata, India.
authors.forename: Nupur
authors.initials: N
authors.lastname: Nandi
keywords: Drospirenone pill; Indian women; androgenic parameters; insulin resistance; polycystic ovary syndrome