title: Rho-directed forces in collective migration.
abstract: Collective cell migration depends on multicellular mechanocoupling between leader and follower cells to coordinate traction force and position change. Co-registration of Rho GTPase activity and forces in migrating epithelial cell sheets now shows how RhoA controls leader-follower cell hierarchy, multicellular cytoskeletal contractility and mechanocoupling, to prevent ectopic leading edges and to move the cell sheet forward.
authors.affiliation: Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
authors.forename: Peter
authors.initials: P
authors.lastname: Friedl
authors.affiliation: David H. Koch Center for Applied Research of Genitourinary Cancers, Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, 77030, USA.
authors.forename: Katarina
authors.initials: K
authors.lastname: Wolf
authors.affiliation: Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.
authors.forename: Mirjam M
authors.initials: MM
authors.lastname: Zegers
mesh_terms: D000818:Animals; D002465:Cell Movement; D020742:rhoA GTP-Binding Protein / Q000502:physiology*
chemical_list: D020742:rhoA GTP-Binding Protein