title: Structural genomics of human proteins.
abstract: Structural genomics efforts focused on the human proteome have had three aims: to understand the structural and functional variations within protein families; to understand the structural basis of disease and genetic variation; and to determine the structures of human integral membrane proteins. The overarching theme is to advance the understanding of human health and to provide a structural platform to aid in the development of therapeutics. A decade or more of work in this field has identified optimal experimental strategies that can be used to expedite expression and crystallization of human proteins-and we provide some guidance to this end.
authors.affiliation: Structural Genomics Consortium, University of Toronto, 101 College Street, MaRS South Tower, Suite 706, Toronto, ON, Canada, M5G 1L7.
authors.forename: Khan Tanjid
authors.initials: KT
authors.lastname: Osman
authors.forename: Aled
authors.initials: A
authors.lastname: Edwards
mesh_terms: D019295:Computational Biology; D018360:Crystallography, X-Ray; D015894:Genome, Human; D023281:Genomics; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D040681:Structural Homology, Protein
chemical_list: D011506:Proteins