title: Cyr61/CTGF/Nov family proteins in gastric carcinogenesis.
abstract: Gastric cancer (GC) is the second leading cause of cancer-related death. The poor survival rate may reflect the relatively aggressive tumor biology of GC. Recently, the importance of the tumor microenvironment in carcinogenesis has emerged. In the tumor microenvironment, tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins capable of modulating carcinogenesis and regulating metastasis. The Cyr61/CTGF/Nov (CCN) proteins are a family of matricellular proteins with variable roles in many physiological and pathological processes. The evidence suggests that CCN family proteins contribute to GC carcinogenic processes. Here, we briefly review recent research on the effects of CCN family proteins in GC carcinogenesis and the development of new targeted agents in this field.
authors.affiliation: Tsu-Yao Cheng, Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
authors.forename: Tsu-Yao
authors.initials: TY
authors.lastname: Cheng
authors.affiliation: Tsu-Yao Cheng, Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
authors.forename: Ming-Shiang
authors.initials: MS
authors.lastname: Wu
authors.affiliation: Tsu-Yao Cheng, Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
authors.forename: Kuo-Tai
authors.initials: KT
authors.lastname: Hua
authors.affiliation: Tsu-Yao Cheng, Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
authors.forename: Min-Liang
authors.initials: ML
authors.lastname: Kuo
authors.affiliation: Tsu-Yao Cheng, Department of Laboratory Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
authors.forename: Ming-Tsan
authors.initials: MT
authors.lastname: Lin
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry; D055511:CCN Intercellular Signaling Proteins / Q000378:metabolism; D063646:Carcinogenesis; D055513:Connective Tissue Growth Factor / Q000378:metabolism*; D055515:Cysteine-Rich Protein 61 / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009362:Neoplasm Metastasis; D055514:Nephroblastoma Overexpressed Protein / Q000378:metabolism; D021382:Protein Sorting Signals; D017434:Protein Structure, Tertiary; D034622:RNA Interference; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality
chemical_list: D000911:Antibodies, Monoclonal; D055511:CCN Intercellular Signaling Proteins; C526317:CCN2 protein, human; C526319:CCN3 protein, human; D055515:Cysteine-Rich Protein 61; D055514:Nephroblastoma Overexpressed Protein; D021382:Protein Sorting Signals; D055513:Connective Tissue Growth Factor
keywords: Connective tissue growth factor; Cyr61/CTGF/Nov proteins; Cysteine-rich angiogenic inducer 61; Gastric cancer; Gastric carcinogenesis; Nephroblastoma over-expressed