title: Acute, subchronic, and developmental toxicological properties of lubricating oil base stocks.
abstract: Lubricating oil base stocks (LOBs) are substances used in the manufacture of finished lubricants and greases. They are produced from residue remaining after atmospheric distillation of crude oil that is subsequently fractionated by vacuum distillation and additional refining steps. Initial LOB streams that have been produced by vacuum distillation but not further refined may contain polycyclic aromatic compounds (PACs) and may present carcinogenic hazards. In modern refineries, LOBs are further refined by multistep processes including solvent extraction and/or hydrogen treatment to reduce the levels of PACs and other undesirable constituents. Thus, mildly (insufficiently) refined LOBs are potentially more hazardous than more severely (sufficiently) refined LOBs. This article discusses the evaluation of LOBs using statistical models based on content of PACs; these models indicate that insufficiently refined LOBs (potentially carcinogenic LOBs) can also produce systemic and developmental effects with repeated dermal exposure. Experimental data were also obtained in ten 13-week dermal studies in rats, eight 4-week dermal studies in rabbits, and seven dermal developmental toxicity studies with sufficiently refined LOBs (noncarcinogenic and commonly marketed) in which no observed adverse effect levels for systemic toxicity and developmental toxicity were 1000 to 2000 mg/kg/d with dermal exposures, typically the highest dose tested. Results in both oral and inhalation developmental toxicity studies were similar. This absence of toxicologically relevant findings was consistent with lower PAC content of sufficiently refined LOBs. Based on data on reproductive organs with repeated dosing and parameters in developmental toxicity studies, sufficiently refined LOBs are likely to have little, if any, effect on reproductive parameters.
authors.affiliation: DalbeyTox, LLC, 860 Penns Way, West Chester, PA, 19382, USA. Email: dalbeytox@verizon.net.
authors.forename: Walden E
authors.initials: WE
authors.lastname: Dalbey
authors.forename: Richard H
authors.initials: RH
authors.lastname: McKee
authors.forename: Katy Olsavsky
authors.initials: KO
authors.lastname: Goyak
authors.forename: Robert W
authors.initials: RW
authors.lastname: Biles
authors.forename: Jay
authors.initials: J
authors.lastname: Murray
authors.forename: Russell
authors.initials: R
authors.lastname: White
mesh_terms: D000279:Administration, Cutaneous; D000280:Administration, Inhalation; D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D007928:Lethal Dose 50; D019055:No-Observed-Adverse-Effect Level; D010578:Petroleum / Q000633:toxicity*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D023382:Toxicity Tests, Acute; D036401:Toxicity Tests, Chronic
chemical_list: D002273:Carcinogens; D010578:Petroleum; D011084:Polycyclic Aromatic Hydrocarbons
keywords: acute; base stock; dermal; developmental; lubricant; mineral oil; petroleum; rat; subchronic; toxicity