title: A summary of the iodine supplementation study protocol (I2S2): a UK multicentre randomised controlled trial in preterm infants.
abstract: This paper summarises the study protocol for the randomised controlled trial of iodine supplementation in preterm infants. Iodine is essential for the synthesis of thyroxine, and thyroxine is essential for normal brain development in utero and for the first 2-3 years of life. The recommended iodine intake in parenteral nutrition regimens is 1 μg/kg/day and commercially available parenteral solutions for infants reflect these recommendations. In the absence of other iodine sources, infants are vulnerable to negative iodine balance and insufficiency. As many preterm infants are fed parenterally for prolonged periods with solutions which have been shown to be iodine-deficient, the I2S2 Trial was designed to establish whether iodine supplementation of preterm infants benefits neurodevelopment.
authors.affiliation: Population Health Sciences, Medical Research Institute, University of Dundee, Dundee, UK.
authors.forename: Fiona
authors.initials: F
authors.lastname: Williams
authors.forename: Robert
authors.initials: R
authors.lastname: Hume
authors.forename: Simon
authors.initials: S
authors.lastname: Ogston
authors.forename: Peter
authors.initials: P
authors.lastname: Brocklehurst
authors.forename: Kayleigh
authors.initials: K
authors.lastname: Morgan
authors.forename: Edmund
authors.initials: E
authors.lastname: Juszczak
mesh_terms: D000367:Age Factors; D002657:Child Development; D002985:Clinical Protocols; D019587:Dietary Supplements / Q000009:adverse effects; D005865:Gestational Age; D006801:Humans; D007227:Infant Nutritional Physiological Phenomena; D062071:Infant, Extremely Premature; D007231:Infant, Newborn; D009420:Nervous System / Q000187:drug effects* / Q000254:growth & development; D009752:Nutritional Status; D010288:Parenteral Nutrition; D064167:Recommended Dietary Allowances; D012107:Research Design; D012974:Sodium Iodide / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D012974:Sodium Iodide