title: Non-association of IL-16 rs4778889 T/C polymorphism with cancer risk in Asians: a meta-analysis.
abstract: The IL-16 rs4778889 T/C polymorphism is associated with cancer risk. However, the results are conflicting. We performed this meta-analysis to derive a more precise estimation of the relationship. A comprehensive literature search was performed using PubMed, Embase and Web of Science databases. Odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association. A total of 6 studies including 1,603 cases and 2,342 controls were identified. With all studies involved, results showed no statistically significant association between IL-16 rs4778889 T/C polymorphism and cancer risk (CC vs. CT+TT: OR=0.74, 95%CI: 0.55-1.02, Ph=0.15; CC+CT vs. TT: OR=0.89, 95%CI: 0.72-1.10, Ph =0.03; CC vs. TT: OR=0.73, 95%CI: 0.53- 1.00, Ph =0.08; CT vs. TT: OR=0.91, 95%CI: 0.79-1.05, Ph =0.08; C vs. T: OR=0.89, 95%CI: 0.74-1.07, Ph =0.02). In addition, the results were not changed when studies were stratified by cancer type. However, to verify our findings, it is essential to perform more well-designed studies with larger sample sizes in the future.
authors.affiliation: Department of Clinical Laboratory, The First People's Hospital of Yancheng, Yancheng, China E-mail : manofgreen@126.com.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Xu
authors.forename: Zhi-Chun
authors.initials: ZC
authors.lastname: Song
authors.forename: Kun
authors.initials: K
authors.lastname: Shang
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Zhao
authors.forename: Zhan-Sheng
authors.initials: ZS
authors.lastname: Zhu
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D019410:Interleukin-16