title: Association of dietary intake with joint space narrowing and osteophytosis at the knee in Japanese men and women: the ROAD study.
abstract: OBJECTIVE
  The objective of the present study is to identify dietary nutrients associated with joint space narrowing (JSN) and osteophytosis at the knee in a population-based cohort of the Research on Osteoarthritis/osteoporosis Against Disability (ROAD) study.
  
  
  METHODS
  From the baseline survey of the ROAD study, 827 participants (305 men and 522 women) in a rural cohort were analyzed. Dietary nutrient intakes for the last month were assessed by a self-administered brief diet history questionnaire. Minimum joint space width (mJSW) and osteophyte area (OPA) in the medial compartment of the knee were measured using a knee osteoarthritis (OA) computer-aided diagnostic system.
  
  
  RESULTS
  In men, there were no associations of dietary nutrient intakes with mJSW or OPA. In women, vitamins K, B1, B2, B6, and C were associated with mJSW after adjustment for age, body mass index, and total energy (p < 0.05). Vitamins E, K, B1, B2, niacin, and B6 were significantly associated with OPA (p < 0.05) in women. Vitamins K, B and C may have a protective role against knee OA in women and might lead to disease-modifying treatments.
  
  
  CONCLUSIONS
  The present study revealed that low dietary intake of vitamins K, B, and C are associated with JSN and osteophytosis in women.
authors.affiliation: Department of Clinical Motor System Medicine, 22nd Century Medical and Research Center, Faculty of Medicine, The University of Tokyo , Tokyo , Japan.
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Muraki
authors.forename: Toru
authors.initials: T
authors.lastname: Akune
authors.forename: Yoshio
authors.initials: Y
authors.lastname: En-yo
authors.forename: Munehito
authors.initials: M
authors.lastname: Yoshida
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Oka
authors.forename: Noriko
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D004032:Diet; D018450:Disease Progression; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000000981:diagnostic imaging*; D054850:Osteophyte / Q000000981:diagnostic imaging*; D011859:Radiography; D012720:Severity of Illness Index; D055815:Young Adult