title: Hereditary multiple exostosis.
abstract: Hereditary multiple exostosis is an intriguing genetic condition with a clinical impact in the field of orthopaedics, paediatrics and oncology. In this review we highlight the current knowledge about this condition from a clinical and scientific point of view. This gives us more insight into the molecular mechanisms and current models on which therapeutic agents are based. It allows for a multidisciplinary approach to the management of this complex condition. There is currently no exact pathological model that can accurately describe all the findings in the research on Hereditary Multiple Exostosis. Promising treatments with blocking agents are currently under investigation.
authors.affiliation: Jan Yperman Hospital, Ypres, Belgium. andries.ryckx@gmail.com
authors.forename: Andries
authors.initials: A
authors.lastname: Ryckx
authors.affiliation: Department of Orthopaedic Surgery, Jan Yperman Hospital, Ypres, Belgium.
authors.forename: Jan F A
authors.initials: JF
authors.lastname: Somers
authors.affiliation: Department of Surgery, Jan Yperman Hospital, Ypres, Belgium.
authors.forename: Lieven
authors.initials: L
authors.lastname: Allaert
mesh_terms: D000818:Animals; D000842:Ankle; D000843:Ankle Joint / Q000000981:diagnostic imaging; D049109:Cell Proliferation; D019902:Chondrocytes / Q000502:physiology; D004550:Elbow; D005097:Exostoses, Multiple Hereditary / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000628:therapy*; D005542:Forearm; D053823:Hedgehog Proteins / Q000235:genetics; D006493:Heparin / Q000031:analogs & derivatives / Q000096:biosynthesis; D006801:Humans; D035002:Lower Extremity; D017351:N-Acetylglucosaminyltransferases / Q000235:genetics; D011509:Proteoglycans / Q000096:biosynthesis; D011859:Radiography; D034941:Upper Extremity; D000099058:Exostosin 1
chemical_list: D053823:Hedgehog Proteins; D011509:Proteoglycans; C036090:heparin proteoglycan; D006493:Heparin; D017351:N-Acetylglucosaminyltransferases; D000099058:Exostosin 1