title: Prostate biopsy sampling causes hematogenous dissemination of epithelial cellular material.
abstract: The extent of epithelial cellular material (ECM) occurring in venous blood samples after diagnostic core needle biopsy (CNB) was studied in 23 patients with CNB diagnosed prostate cancer without provable metastases and 15 patients without cancer. The data show a significant increase of ECM in the peripheral blood sampled 20 seconds or 30 minutes after the last of 10 CNB procedures compared to the number of ECM detectable in the blood samples taken before the performance of CNB. The data indicate that diagnostic CNB of prostate cancer causes an extensive tissue trauma with a potential risk of cancer cell dissemination.
authors.affiliation: Surgical Science, Uppsala University, 751 85 Uppsala, Sweden.
authors.forename: Sam
authors.initials: S
authors.lastname: Ladjevardi
authors.affiliation: Karolinska Biomic Center, Karolinska Institutet, 171 76 Stockholm, Sweden.
authors.forename: Gert
authors.initials: G
authors.lastname: Auer
authors.affiliation: Department of Oncology-Pathology, CCK R8:04, Karolinska Institutet, 171 76 Stockholm, Sweden.
authors.forename: Juan
authors.initials: J
authors.lastname: Castro
authors.affiliation: Department of Oncology-Pathology, CCK R8:04, Karolinska Institutet, 171 76 Stockholm, Sweden.
authors.forename: Christer
authors.initials: C
authors.lastname: Ericsson
authors.affiliation: Department of Oncology-Pathology, CCK R8:04, Karolinska Institutet, 171 76 Stockholm, Sweden.
authors.forename: Anders
authors.initials: A
authors.lastname: Zetterberg
authors.affiliation: Surgical Science, Uppsala University, 751 85 Uppsala, Sweden.
authors.forename: Michael
authors.initials: M
authors.lastname: Häggman
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, c/o Hans Wiksell, Comair AB, P.O. Box 39011, 100 54 Stockholm, Sweden.
authors.forename: Hans
authors.identifier: 0000-0003-2321-2068
authors.initials: H
authors.lastname: Wiksell
authors.affiliation: Radiology, Oncology and Radiation Science, Section of Radiology, Uppsala University, 751 85 Uppsala, Sweden.
authors.forename: Håkan
authors.initials: H
authors.lastname: Jorulf
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D062005:Biopsy, Large-Core Needle; D055252:Cell-Derived Microparticles / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor