title: Merging gold and organocatalysis: a facile asymmetric synthesis of annulated pyrroles.
abstract: The combination of cinchona-alkaloid-derived primary amine and Au(I) -phosphine catalysts allowed the selective C-H functionalization of two adjacent carbon atoms of pyrroles under mild reaction conditions. This sequential dual activation provides seven-membered-ring-annulated pyrrole derivatives in excellent yields and enantioselectivities.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen (Germany), Fax: (+49) 241-809-2127.
authors.forename: Daniel
authors.initials: D
authors.lastname: Hack
authors.forename: Charles C J
authors.initials: CC
authors.lastname: Loh
authors.forename: Jan M
authors.initials: JM
authors.lastname: Hartmann
authors.forename: Gerhard
authors.initials: G
authors.lastname: Raabe
authors.forename: Dieter
authors.initials: D
authors.lastname: Enders
keywords: annulation; gold catalysis; organocatalysis; primary-amine catalysis; pyrroles