title: Acute ischemic stroke secondary to glioblastoma. A case report.
abstract: Glioblastoma is a malignant infiltrative glial tumor occurring most often over 50 years of age, with diverse clinical presentations. We describe a case of temporal lobe glioblastoma with a rare presentation as an acute ischemic stroke, discussing the imaging and histopathological findings, and reviewing the literature. A 77-year-old woman had sudden onset of left hemiparesis and hemihypoesthesia. The neuroradiological studies revealed an acute ischemic lesion in the right lenticulostriate arteries territory and a right anterior temporal lobe tumor, enhancing heterogeneously after contrast with enhancement of the right middle cerebral artery wall. Histopathological analysis of the resected temporal lesion revealed a glioblastoma multiforme with tumoral infiltration of the vascular wall. Glioblastoma should be considered in the etiology of acute ischemic stroke, where neuroimaging plays an important diagnostic role, enabling a more immediate therapeutic approach, with a consequent impact on survival.
authors.affiliation: Serviço de Neurorradiologia, Hospital de Santo António - CHP; Porto, Portugal - sofiapina@mail.com.
authors.forename: Sofia
authors.initials: S
authors.lastname: Pina
authors.affiliation: Serviço de Neurorradiologia, Hospital de Santo António - CHP; Porto, Portugal.
authors.forename: Ângelo
authors.initials: Â
authors.lastname: Carneiro
authors.affiliation: Serviço de Neurorradiologia, Hospital de Santo António - CHP; Porto, Portugal.
authors.forename: Tiago
authors.initials: T
authors.lastname: Rodrigues
authors.affiliation: Serviço de Neurorradiologia, Hospital de Santo António - CHP; Porto, Portugal.
authors.forename: Raquel
authors.initials: R
authors.lastname: Samões
authors.affiliation: Serviço de Neurorradiologia, Hospital de Santo António - CHP; Porto, Portugal.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Taipa
authors.affiliation: Serviço de Neurorradiologia, Hospital de Santo António - CHP; Porto, Portugal.
authors.forename: Manuel
authors.initials: M
authors.lastname: Melo-Pires
authors.affiliation: Serviço de Neurorradiologia, Hospital de Santo António - CHP; Porto, Portugal.
authors.forename: Cláudia
authors.initials: C
authors.lastname: Pereira
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000209:etiology* / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology; D002533:Cerebral Angiography; D005260:Female; D005909:Glioblastoma / Q000150:complications* / Q000473:pathology; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D010291:Paresis / Q000209:etiology; D020521:Stroke / Q000209:etiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed
keywords: computed tomography; glioblastoma; magnetic resonance imaging; stroke; vasculopathy