title: Synthesis and antiproliferative evaluation of 13-aryl-13H-benzo[g]benzothiazolo [2,3-b]quinazoline-5,14-diones.
abstract: A simple synthesis of novel 13-aryl-13H-benzo[g]benzothiazolo [2,3-b]quinazoline-5,14-dione derivatives was accomplished in excellent yields via the reaction of 2-aminobenzothiazole, aromatic aldehydes and 2-hydroxy-1,4-naphthoquinone in the presence of amberlyst-15. The antiproliferative activities of all the synthesized compounds were assessed on two different human cancer cell lines (HepG2 and Hela), and the results showed that most of the new compounds showed good to potent cytotoxic activities.
authors.affiliation: School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China. Electronic address: wliq1974@163.com.
authors.forename: Liqiang
authors.initials: L
authors.lastname: Wu
authors.affiliation: School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
authors.forename: Chong
authors.initials: C
authors.lastname: Zhang
authors.affiliation: School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, China.
authors.forename: Weilin
authors.initials: W
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D052160:Benzothiazoles / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D057809:HEK293 Cells; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D052160:Benzothiazoles; D011799:Quinazolines
keywords: 1,4-Naphthoquinones; 2-Hydroxy-1,4-naphthoquinone; Aldehydes; Amberlyst-15; Antiproliferative; Solvent-free